locus-tag	class	description
GPY20_RS00005	COG4989	oxidoreductase activity
GPY20_RS00010	COG3275	phosphorelay sensor kinase activity
GPY20_RS00015	COG3279	Response regulator of the LytR AlgR family
GPY20_RS00020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY20_RS00040	COG0840	transmembrane signaling receptor activity
GPY20_RS00050	COG2814	Major facilitator Superfamily
GPY20_RS00070	COG1522	sequence-specific DNA binding
GPY20_RS00080	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY20_RS00085	COG5380	lipid catabolic process
GPY20_RS00090	COG3291	Pkd domain containing protein
GPY20_RS00090	COG4412	M6 family metalloprotease domain protein
GPY20_RS00110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY20_RS00115	COG4605	iron ion homeostasis
GPY20_RS00120	COG4604	ABC transporter, ATP-binding protein
GPY20_RS00125	COG2207	Transcriptional regulator
GPY20_RS00125	COG3708	Transcriptional regulator
GPY20_RS00140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY20_RS00180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY20_RS00185	COG1454	alcohol dehydrogenase
GPY20_RS00190	COG2207	Transcriptional regulator
GPY20_RS00190	COG1609	Transcriptional regulator
GPY20_RS00210	COG0456	acetyltransferase
GPY20_RS00220	COG3634	alkyl hydroperoxide reductase activity
GPY20_RS00225	COG0450	alkyl hydroperoxide reductase
GPY20_RS00240	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY20_RS00245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY20_RS00250	COG1960	acyl-CoA dehydrogenase activity
GPY20_RS00260	COG0183	Belongs to the thiolase family
GPY20_RS00270	COG1960	acyl-CoA dehydrogenase activity
GPY20_RS00275	COG1024	Enoyl-CoA hydratase
GPY20_RS00280	COG1024	Enoyl-CoA hydratase
GPY20_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS00300	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS00310	COG2814	Major facilitator Superfamily
GPY20_RS00315	COG0653	protein targeting
GPY20_RS00330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY20_RS00350	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY20_RS00350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY20_RS00355	COG1464	Belongs to the NlpA lipoprotein family
GPY20_RS00375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY20_RS00380	COG0573	inorganic phosphate transmembrane transporter activity
GPY20_RS00390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY20_RS00410	COG0625	glutathione transferase activity
GPY20_RS00465	COG2721	sulfolactate sulfo-lyase activity
GPY20_RS00480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY20_RS00490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY20_RS00495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY20_RS00500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY20_RS00520	COG1473	amidohydrolase
GPY20_RS00535	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS00540	COG0400	carboxylic ester hydrolase activity
GPY20_RS00545	COG0435	Glutathione S-transferase
GPY20_RS00550	COG0583	DNA-binding transcription factor activity
GPY20_RS00555	COG4145	pantothenate transmembrane transporter activity
GPY20_RS00565	COG2423	ornithine cyclodeaminase activity
GPY20_RS00580	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY20_RS00605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY20_RS00615	COG2205	protein histidine kinase activity
GPY20_RS00615	COG3850	Histidine kinase
GPY20_RS00615	COG4999	Histidine kinase
GPY20_RS00615	COG3437	response regulator, receiver
GPY20_RS00620	COG5002	protein histidine kinase activity
GPY20_RS00620	COG0784	Response regulator, receiver
GPY20_RS00620	COG2205	protein histidine kinase activity
GPY20_RS00625	COG3437	response regulator, receiver
GPY20_RS00635	COG4172	Belongs to the ABC transporter superfamily
GPY20_RS00640	COG0747	negative chemotaxis
GPY20_RS00660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY20_RS00665	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY20_RS00675	COG3706	GGDEF domain
GPY20_RS00680	COG0110	maltose O-acetyltransferase activity
GPY20_RS00685	COG1349	DNA-binding transcription factor activity
GPY20_RS00695	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY20_RS00710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS00720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS00720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS00720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY20_RS00725	COG2207	Transcriptional regulator
GPY20_RS00735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS00740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS00750	COG1252	NADH dehydrogenase
GPY20_RS00760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY20_RS00765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY20_RS00770	COG4232	protein-disulfide reductase activity
GPY20_RS00775	COG3710	Transcriptional regulator
GPY20_RS00790	COG0583	DNA-binding transcription factor activity
GPY20_RS00800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY20_RS00810	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY20_RS00815	COG0513	Belongs to the DEAD box helicase family
GPY20_RS00820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY20_RS00860	COG4628	conserved protein (DUF2132)
GPY20_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS00925	COG0789	Transcriptional regulator
GPY20_RS00930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY20_RS00990	COG0454	-acetyltransferase
GPY20_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS01020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY20_RS01050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY20_RS01060	COG0494	nUDIX hydrolase
GPY20_RS01065	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS01075	COG0456	acetyltransferase
GPY20_RS01080	COG4977	sequence-specific DNA binding
GPY20_RS01085	COG1335	isochorismatase
GPY20_RS01115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY20_RS01120	COG1309	transcriptional regulator
GPY20_RS01135	COG0583	DNA-binding transcription factor activity
GPY20_RS01145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY20_RS01155	COG0745	RESPONSE REGULATOR receiver
GPY20_RS01160	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS01215	COG1328	CTP reductase activity
GPY20_RS01220	COG0602	queuosine metabolic process
GPY20_RS01230	COG0189	ligase activity
GPY20_RS01230	COG4067	protein conserved in archaea
GPY20_RS01235	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY20_RS01235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS01235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS01240	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY20_RS01245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY20_RS01245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY20_RS01250	COG1609	Transcriptional regulator
GPY20_RS01260	COG0419	ATPase involved in DNA repair
GPY20_RS01265	COG2205	protein histidine kinase activity
GPY20_RS01265	COG0784	Response regulator, receiver
GPY20_RS01270	COG0156	8-amino-7-oxononanoate synthase activity
GPY20_RS01280	COG0038	chloride channel
GPY20_RS01285	COG0523	cobalamin synthesis protein
GPY20_RS01295	COG2207	Transcriptional regulator
GPY20_RS01305	COG3437	response regulator, receiver
GPY20_RS01310	COG0784	Response regulator, receiver
GPY20_RS01310	COG2205	protein histidine kinase activity
GPY20_RS01310	COG5002	protein histidine kinase activity
GPY20_RS01315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY20_RS01315	COG0543	2 iron, 2 sulfur cluster binding
GPY20_RS01320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY20_RS01325	COG0243	molybdopterin cofactor binding
GPY20_RS01335	COG5001	Diguanylate cyclase
GPY20_RS01360	COG3038	cytochrome b561
GPY20_RS01365	COG2353	YceI-like domain
GPY20_RS01370	COG2116	formate transmembrane transporter activity
GPY20_RS01375	COG0583	DNA-binding transcription factor activity
GPY20_RS01385	COG3593	DNA synthesis involved in DNA repair
GPY20_RS01390	COG0737	Belongs to the 5'-nucleotidase family
GPY20_RS01395	COG0861	Integral membrane protein TerC family
GPY20_RS01405	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY20_RS01410	COG0501	Belongs to the peptidase M48B family
GPY20_RS01415	COG2050	protein possibly involved in aromatic compounds catabolism
GPY20_RS01435	COG4771	TonB-dependent receptor
GPY20_RS01435	COG1629	transport
GPY20_RS01440	COG0583	DNA-binding transcription factor activity
GPY20_RS01445	COG1042	CoA-binding domain protein
GPY20_RS01445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY20_RS01445	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY20_RS01455	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY20_RS01470	COG0023	Translation Initiation Factor
GPY20_RS01545	COG0745	RESPONSE REGULATOR receiver
GPY20_RS01555	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY20_RS01560	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY20_RS01575	COG0745	RESPONSE REGULATOR receiver
GPY20_RS01575	COG3706	GGDEF domain
GPY20_RS01585	COG3706	GGDEF domain
GPY20_RS01595	COG1309	transcriptional regulator
GPY20_RS01600	COG1129	ABC transporter
GPY20_RS01640	COG2351	hydroxyisourate hydrolase activity
GPY20_RS01645	COG0402	S-adenosylhomocysteine deaminase activity
GPY20_RS01665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY20_RS01695	COG0765	amino acid transport
GPY20_RS01700	COG0765	amino acid transport
GPY20_RS01710	COG1953	Uracil, thiamine, allantoin
GPY20_RS01730	COG2233	PERMEase
GPY20_RS01745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY20_RS01775	COG3710	Transcriptional regulator
GPY20_RS01795	COG2814	Major facilitator Superfamily
GPY20_RS01815	COG0488	(ABC) transporter
GPY20_RS01825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GPY20_RS01845	COG2207	Transcriptional regulator
GPY20_RS01850	COG1979	alcohol dehydrogenase
GPY20_RS01915	COG2501	S4 domain
GPY20_RS01925	COG3706	GGDEF domain
GPY20_RS01935	COG3706	GGDEF domain
GPY20_RS01935	COG4251	negative regulation of phosphorylation
GPY20_RS01935	COG5001	Diguanylate cyclase
GPY20_RS01935	COG2203	Gaf domain
GPY20_RS01940	COG0784	Response regulator, receiver
GPY20_RS01940	COG2205	protein histidine kinase activity
GPY20_RS01955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY20_RS01960	COG4172	Belongs to the ABC transporter superfamily
GPY20_RS01965	COG4239	(ABC) transporter, permease
GPY20_RS01970	COG4174	ABC transporter (Permease)
GPY20_RS01975	COG4166	transmembrane transport
GPY20_RS02000	COG2866	Carboxypeptidase
GPY20_RS02020	COG3842	ATPase activity
GPY20_RS02030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY20_RS02050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY20_RS02055	COG1011	Hydrolase
GPY20_RS02065	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY20_RS02070	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY20_RS02075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY20_RS02075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY20_RS02090	COG4303	Ethanolamine ammonia lyase large subunit
GPY20_RS02100	COG0531	amino acid
GPY20_RS02105	COG0302	gtp cyclohydrolase
GPY20_RS02115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY20_RS02120	COG2897	thiosulfate sulfurtransferase activity
GPY20_RS02135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY20_RS02140	COG0840	transmembrane signaling receptor activity
GPY20_RS02155	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY20_RS02160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY20_RS02165	COG0840	transmembrane signaling receptor activity
GPY20_RS02170	COG2814	Major facilitator Superfamily
GPY20_RS02185	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY20_RS02190	COG2197	response regulator
GPY20_RS02195	COG3850	Histidine kinase
GPY20_RS02210	COG0243	molybdopterin cofactor binding
GPY20_RS02250	COG0183	Belongs to the thiolase family
GPY20_RS02260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY20_RS02265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY20_RS02285	COG3706	GGDEF domain
GPY20_RS02290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY20_RS02305	COG2207	Transcriptional regulator
GPY20_RS02310	COG1979	alcohol dehydrogenase
GPY20_RS02330	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY20_RS02335	COG2271	Major facilitator Superfamily
GPY20_RS02340	COG0469	pyruvate kinase activity
GPY20_RS02345	COG2198	Histidine kinase
GPY20_RS02345	COG0784	Response regulator, receiver
GPY20_RS02345	COG2205	protein histidine kinase activity
GPY20_RS02350	COG1879	ABC-type sugar transport system periplasmic component
GPY20_RS02355	COG1803	Methylglyoxal synthase
GPY20_RS02360	COG1335	isochorismatase
GPY20_RS02365	COG0210	DNA helicase
GPY20_RS02415	COG1289	transmembrane transporter activity
GPY20_RS02430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY20_RS02435	COG4149	molybdate abc transporter
GPY20_RS02440	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY20_RS02445	COG1492	cobalamin metabolic process
GPY20_RS02465	COG0784	Response regulator, receiver
GPY20_RS02465	COG5002	protein histidine kinase activity
GPY20_RS02470	COG1879	ABC-type sugar transport system periplasmic component
GPY20_RS02480	COG2827	Endonuclease containing a URI domain
GPY20_RS02500	COG4974	Belongs to the 'phage' integrase family
GPY20_RS02530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY20_RS02535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY20_RS02540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY20_RS02545	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY20_RS02550	COG0247	lactate metabolic process
GPY20_RS02565	COG0297	glycogen (starch) synthase activity
GPY20_RS02565	COG0438	transferase activity, transferring glycosyl groups
GPY20_RS02570	COG0438	transferase activity, transferring glycosyl groups
GPY20_RS02595	COG1596	polysaccharide export
GPY20_RS02605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY20_RS02620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY20_RS02625	COG3118	belongs to the thioredoxin family
GPY20_RS02630	COG2814	Major facilitator Superfamily
GPY20_RS02660	COG2116	formate transmembrane transporter activity
GPY20_RS02665	COG2146	nitrite reductase [NAD(P)H] activity
GPY20_RS02670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY20_RS02700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY20_RS02730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY20_RS02745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY20_RS02755	COG1070	Carbohydrate kinase
GPY20_RS02765	COG2390	Transcriptional regulator
GPY20_RS02775	COG1294	oxidase, subunit
GPY20_RS02780	COG1271	oxidase subunit
GPY20_RS02785	COG0243	molybdopterin cofactor binding
GPY20_RS02790	COG3781	membrane
GPY20_RS02795	COG0583	DNA-binding transcription factor activity
GPY20_RS02800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY20_RS02815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPY20_RS02825	COG0330	HflC and HflK could
GPY20_RS02850	COG1917	Cupin 2, conserved barrel domain protein
GPY20_RS02850	COG2207	Transcriptional regulator
GPY20_RS02855	COG0697	spore germination
GPY20_RS02860	COG0583	DNA-binding transcription factor activity
GPY20_RS02870	COG0463	Glycosyl transferase, family 2
GPY20_RS02880	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY20_RS02920	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY20_RS02935	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY20_RS02945	COG1309	transcriptional regulator
GPY20_RS02950	COG0513	Belongs to the DEAD box helicase family
GPY20_RS02955	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY20_RS02960	COG0814	amino acid
GPY20_RS02965	COG0840	transmembrane signaling receptor activity
GPY20_RS02970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY20_RS02975	COG3447	MASE1 domain protein
GPY20_RS02975	COG5001	Diguanylate cyclase
GPY20_RS02975	COG5002	protein histidine kinase activity
GPY20_RS02980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY20_RS02990	COG1984	allophanate hydrolase subunit 2
GPY20_RS03000	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY20_RS03005	COG4181	ATPase activity
GPY20_RS03015	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY20_RS03020	COG5001	Diguanylate cyclase
GPY20_RS03020	COG1716	ATPase activity
GPY20_RS03030	COG0484	heat shock protein binding
GPY20_RS03050	COG0546	phosphoglycolate phosphatase activity
GPY20_RS03065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY20_RS03070	COG5001	Diguanylate cyclase
GPY20_RS03075	COG3706	GGDEF domain
GPY20_RS03085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY20_RS03100	COG0509	glycine decarboxylation via glycine cleavage system
GPY20_RS03105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY20_RS03105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY20_RS03125	COG3122	Protein conserved in bacteria
GPY20_RS03170	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS03190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY20_RS03200	COG2985	domain, Protein
GPY20_RS03215	COG0840	transmembrane signaling receptor activity
GPY20_RS03230	COG0513	Belongs to the DEAD box helicase family
GPY20_RS03235	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS03245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY20_RS03255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY20_RS03290	COG3338	carbonate dehydratase activity
GPY20_RS03295	COG1289	transmembrane transporter activity
GPY20_RS03300	COG1566	PFAM secretion protein HlyD family protein
GPY20_RS03315	COG1686	Belongs to the peptidase S11 family
GPY20_RS03325	COG0765	amino acid transport
GPY20_RS03340	COG1522	sequence-specific DNA binding
GPY20_RS03350	COG1166	arginine decarboxylase activity
GPY20_RS03360	COG4175	Glycine betaine
GPY20_RS03365	COG4176	ABC-type proline glycine betaine transport system permease component
GPY20_RS03370	COG2113	Glycine betaine
GPY20_RS03390	COG2239	Acts as a magnesium transporter
GPY20_RS03395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY20_RS03410	COG0113	porphobilinogen synthase activity
GPY20_RS03420	COG0784	Response regulator, receiver
GPY20_RS03420	COG3437	response regulator, receiver
GPY20_RS03430	COG0583	DNA-binding transcription factor activity
GPY20_RS03440	COG0561	phosphatase activity
GPY20_RS03445	COG0527	aspartate kinase activity
GPY20_RS03450	COG0662	Cupin 2, conserved barrel domain protein
GPY20_RS03455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY20_RS03460	COG0456	acetyltransferase
GPY20_RS03470	COG0861	Integral membrane protein TerC family
GPY20_RS03480	COG0534	Mate efflux family protein
GPY20_RS03485	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY20_RS03490	COG3186	Phenylalanine-4-hydroxylase
GPY20_RS03495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY20_RS03505	COG0642	Histidine kinase
GPY20_RS03510	COG0745	RESPONSE REGULATOR receiver
GPY20_RS03530	COG1022	Amp-dependent synthetase and ligase
GPY20_RS03540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY20_RS03565	COG2171	N-acyltransferase activity
GPY20_RS03575	COG1765	OsmC-like protein
GPY20_RS03590	COG5001	Diguanylate cyclase
GPY20_RS03590	COG3300	MHYT domain
GPY20_RS03595	COG5002	protein histidine kinase activity
GPY20_RS03595	COG0784	Response regulator, receiver
GPY20_RS03595	COG2205	protein histidine kinase activity
GPY20_RS03620	COG2200	EAL domain
GPY20_RS03625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY20_RS03655	COG1522	sequence-specific DNA binding
GPY20_RS03660	COG0531	amino acid
GPY20_RS03670	COG0748	coenzyme F420 binding
GPY20_RS03675	COG3721	Heme iron utilization protein
GPY20_RS03680	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY20_RS03685	COG0811	peptide transport
GPY20_RS03690	COG0848	biopolymer transport protein
GPY20_RS03700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY20_RS03705	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY20_RS03735	COG0633	Ferredoxin
GPY20_RS03735	COG3217	Mosc domain protein beta barrel domain protein
GPY20_RS03740	COG0418	dihydroorotase activity
GPY20_RS03745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY20_RS03750	COG2354	Protein conserved in bacteria
GPY20_RS03770	COG1349	DNA-binding transcription factor activity
GPY20_RS03810	COG3842	ATPase activity
GPY20_RS03850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY20_RS03860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY20_RS03880	COG0517	IMP dehydrogenase activity
GPY20_RS03885	COG1414	Transcriptional regulator
GPY20_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS03900	COG1917	Cupin 2, conserved barrel domain protein
GPY20_RS03915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY20_RS03920	COG0800	Aldolase
GPY20_RS03940	COG1175	transmembrane transport
GPY20_RS03945	COG0395	ABC-type sugar transport system, permease component
GPY20_RS03950	COG3842	ATPase activity
GPY20_RS03955	COG1653	transport
GPY20_RS03965	COG0534	Mate efflux family protein
GPY20_RS03970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY20_RS03975	COG0823	Involved in the tonB-independent uptake of proteins
GPY20_RS03980	COG0393	Putative heavy-metal-binding
GPY20_RS03990	COG1522	sequence-specific DNA binding
GPY20_RS04010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY20_RS04025	COG1942	4-Oxalocrotonate Tautomerase
GPY20_RS04040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY20_RS04045	COG0784	Response regulator, receiver
GPY20_RS04045	COG0835	chemotaxis
GPY20_RS04050	COG2315	Protein conserved in bacteria
GPY20_RS04055	COG1846	Transcriptional regulator
GPY20_RS04065	COG3706	GGDEF domain
GPY20_RS04085	COG3706	GGDEF domain
GPY20_RS04110	COG5001	Diguanylate cyclase
GPY20_RS04120	COG1741	Belongs to the pirin family
GPY20_RS04125	COG0745	RESPONSE REGULATOR receiver
GPY20_RS04130	COG2205	protein histidine kinase activity
GPY20_RS04230	COG3501	Rhs element vgr protein
GPY20_RS04240	COG2814	Major facilitator Superfamily
GPY20_RS04250	COG3123	guanosine phosphorylase activity
GPY20_RS04260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY20_RS04265	COG0569	domain protein
GPY20_RS04270	COG0668	transmembrane transport
GPY20_RS04275	COG2211	Major facilitator Superfamily
GPY20_RS04285	COG1067	ATP-dependent peptidase activity
GPY20_RS04295	COG4172	Belongs to the ABC transporter superfamily
GPY20_RS04300	COG0583	DNA-binding transcription factor activity
GPY20_RS04305	COG1620	l-lactate permease
GPY20_RS04310	COG1304	FMN binding
GPY20_RS04335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY20_RS04345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY20_RS04355	COG3152	Membrane
GPY20_RS04375	COG0583	DNA-binding transcription factor activity
GPY20_RS04390	COG1942	4-Oxalocrotonate Tautomerase
GPY20_RS04400	COG0625	glutathione transferase activity
GPY20_RS04405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY20_RS04410	COG0477	Major facilitator Superfamily
GPY20_RS04415	COG0697	spore germination
GPY20_RS04420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY20_RS04440	COG2169	Transcriptional regulator
GPY20_RS04470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY20_RS04485	COG0109	protoheme IX farnesyltransferase activity
GPY20_RS04490	COG1612	heme a metabolic process
GPY20_RS04520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY20_RS04530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY20_RS04535	COG1902	pentaerythritol trinitrate reductase activity
GPY20_RS04545	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS04565	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPY20_RS04570	COG1846	Transcriptional regulator
GPY20_RS04575	COG1764	response to oxidative stress
GPY20_RS04625	COG1301	dicarboxylic acid transport
GPY20_RS04630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY20_RS04640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY20_RS04645	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY20_RS04650	COG2259	Doxx family
GPY20_RS04655	COG0402	S-adenosylhomocysteine deaminase activity
GPY20_RS04680	COG0363	glucosamine-6-phosphate deaminase activity
GPY20_RS04695	COG0739	heme binding
GPY20_RS04700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY20_RS04700	COG2213	PTS system mannitol-specific
GPY20_RS04710	COG3722	fumarate hydratase activity
GPY20_RS04725	COG1473	amidohydrolase
GPY20_RS04730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY20_RS04745	COG0095	Lipoate-protein ligase
GPY20_RS04750	COG0443	Heat shock 70 kDa protein
GPY20_RS04770	COG2176	DNA-directed DNA polymerase activity
GPY20_RS04790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY20_RS04800	COG1403	HNH endonuclease
GPY20_RS04825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY20_RS04835	COG3304	Inner membrane component domain
GPY20_RS04840	COG2329	Antibiotic biosynthesis monooxygenase
GPY20_RS04855	COG2207	Transcriptional regulator
GPY20_RS04855	COG1609	Transcriptional regulator
GPY20_RS04860	COG1335	isochorismatase
GPY20_RS04875	COG2910	NAD(P)H-binding
GPY20_RS04880	COG0583	DNA-binding transcription factor activity
GPY20_RS04895	COG1349	DNA-binding transcription factor activity
GPY20_RS04900	COG2084	Dehydrogenase
GPY20_RS04905	COG3395	kinase activity
GPY20_RS04910	COG0235	Class ii aldolase
GPY20_RS04915	COG3622	Belongs to the hyi family
GPY20_RS04920	COG2610	gluconate transmembrane transporter activity
GPY20_RS04925	COG1522	sequence-specific DNA binding
GPY20_RS04930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY20_RS04935	COG0724	RNA recognition motif
GPY20_RS04950	COG2226	methyltransferase
GPY20_RS04955	COG0583	DNA-binding transcription factor activity
GPY20_RS04965	COG0513	Belongs to the DEAD box helicase family
GPY20_RS04975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY20_RS04990	COG0840	transmembrane signaling receptor activity
GPY20_RS05020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY20_RS05030	COG0259	pyridoxamine-phosphate oxidase activity
GPY20_RS05060	COG0745	RESPONSE REGULATOR receiver
GPY20_RS05075	COG2201	protein-glutamate methylesterase activity
GPY20_RS05085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY20_RS05090	COG0840	transmembrane signaling receptor activity
GPY20_RS05095	COG0835	chemotaxis
GPY20_RS05100	COG0835	chemotaxis
GPY20_RS05105	COG2198	Histidine kinase
GPY20_RS05105	COG0643	Histidine kinase
GPY20_RS05110	COG0745	RESPONSE REGULATOR receiver
GPY20_RS05120	COG1444	tRNA N-acetyltransferase activity
GPY20_RS05125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY20_RS05160	COG0217	transcriptional regulatory protein
GPY20_RS05175	COG2084	Dehydrogenase
GPY20_RS05190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY20_RS05195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY20_RS05200	COG1845	cytochrome c oxidase, subunit III
GPY20_RS05205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY20_RS05220	COG2909	trisaccharide binding
GPY20_RS05225	COG0058	SHG alpha-glucan phosphorylase activity
GPY20_RS05230	COG1640	4-alpha-glucanotransferase
GPY20_RS05235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY20_RS05245	COG3501	Rhs element vgr protein
GPY20_RS05265	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GPY20_RS05290	COG0471	metal ion transport
GPY20_RS05300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY20_RS05305	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY20_RS05310	COG3033	Beta-eliminating lyase
GPY20_RS05320	COG2188	Transcriptional regulator
GPY20_RS05325	COG1131	(ABC) transporter
GPY20_RS05335	COG0840	transmembrane signaling receptor activity
GPY20_RS05350	COG3383	formate dehydrogenase (NAD+) activity
GPY20_RS05370	COG1132	(ABC) transporter
GPY20_RS05390	COG4580	involved in the transport of maltose and maltodextrins
GPY20_RS05405	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY20_RS05410	COG1162	GTPase activity
GPY20_RS05420	COG1999	signal sequence binding
GPY20_RS05435	COG0786	glutamate:sodium symporter activity
GPY20_RS05470	COG1566	PFAM secretion protein HlyD family protein
GPY20_RS05480	COG3706	GGDEF domain
GPY20_RS05495	COG0813	purine-nucleoside phosphorylase activity
GPY20_RS05500	COG3272	Protein of unknown function (DUF1722)
GPY20_RS05510	COG0415	Belongs to the DNA photolyase family
GPY20_RS05515	COG1388	LysM domain
GPY20_RS05515	COG1376	ErfK ybiS ycfS ynhG family protein
GPY20_RS05525	COG0513	Belongs to the DEAD box helicase family
GPY20_RS05530	COG0840	transmembrane signaling receptor activity
GPY20_RS05535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY20_RS05540	COG0573	inorganic phosphate transmembrane transporter activity
GPY20_RS05545	COG0581	inorganic phosphate transmembrane transporter activity
GPY20_RS05555	COG2199	diguanylate cyclase activity
GPY20_RS05570	COG0659	secondary active sulfate transmembrane transporter activity
GPY20_RS05585	COG0739	heme binding
GPY20_RS05590	COG3300	MHYT domain
GPY20_RS05590	COG5001	Diguanylate cyclase
GPY20_RS05595	COG0583	DNA-binding transcription factor activity
GPY20_RS05600	COG2814	Major facilitator Superfamily
GPY20_RS05615	COG0697	spore germination
GPY20_RS05620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY20_RS05630	COG0583	DNA-binding transcription factor activity
GPY20_RS05635	COG0778	Nitroreductase
GPY20_RS05640	COG1342	Belongs to the UPF0251 family
GPY20_RS05650	COG0583	DNA-binding transcription factor activity
GPY20_RS05655	COG3384	dioxygenase
GPY20_RS05660	COG0840	transmembrane signaling receptor activity
GPY20_RS05685	COG4774	siderophore transport
GPY20_RS05690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY20_RS05695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY20_RS05700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY20_RS05705	COG1120	ATPase activity
GPY20_RS05715	COG0583	DNA-binding transcription factor activity
GPY20_RS05720	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS05725	COG3240	lipase activity
GPY20_RS05745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY20_RS05750	COG1349	DNA-binding transcription factor activity
GPY20_RS05755	COG0673	inositol 2-dehydrogenase activity
GPY20_RS05760	COG4702	Belongs to the UPF0303 family
GPY20_RS05770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY20_RS05785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY20_RS05805	COG2814	Major facilitator Superfamily
GPY20_RS05810	COG0583	DNA-binding transcription factor activity
GPY20_RS05815	COG1902	pentaerythritol trinitrate reductase activity
GPY20_RS05820	COG0656	L-ascorbic acid biosynthetic process
GPY20_RS05825	COG2200	EAL domain
GPY20_RS05835	COG3842	ATPase activity
GPY20_RS05865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY20_RS05880	COG2130	NADP-dependent
GPY20_RS05885	COG1309	transcriptional regulator
GPY20_RS05890	COG0564	pseudouridine synthase activity
GPY20_RS05905	COG1846	Transcriptional regulator
GPY20_RS05910	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS06005	COG3501	Rhs element vgr protein
GPY20_RS06020	COG1869	D-ribose catabolic process
GPY20_RS06025	COG1129	ABC transporter
GPY20_RS06030	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY20_RS06035	COG1879	ABC-type sugar transport system periplasmic component
GPY20_RS06040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY20_RS06050	COG0583	DNA-binding transcription factor activity
GPY20_RS06055	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY20_RS06060	COG0584	glycerophosphoryl diester phosphodiesterase
GPY20_RS06065	COG2271	Major facilitator Superfamily
GPY20_RS06070	COG3300	MHYT domain
GPY20_RS06070	COG5001	Diguanylate cyclase
GPY20_RS06095	COG2188	Transcriptional regulator
GPY20_RS06100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY20_RS06100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS06100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY20_RS06105	COG0383	alpha-mannosidase activity
GPY20_RS06110	COG1929	Belongs to the glycerate kinase type-1 family
GPY20_RS06120	COG2204	response regulator
GPY20_RS06135	COG0579	oxidoreductase
GPY20_RS06145	COG3530	Putative quorum-sensing-regulated virulence factor
GPY20_RS06155	COG0589	response to stress
GPY20_RS06160	COG3171	Protein conserved in bacteria
GPY20_RS06185	COG0583	DNA-binding transcription factor activity
GPY20_RS06210	COG4948	Mandelate Racemase Muconate Lactonizing
GPY20_RS06235	COG1012	belongs to the aldehyde dehydrogenase family
GPY20_RS06240	COG3724	N-succinylarginine dihydrolase activity
GPY20_RS06250	COG3706	GGDEF domain
GPY20_RS06250	COG0745	RESPONSE REGULATOR receiver
GPY20_RS06255	COG2205	protein histidine kinase activity
GPY20_RS06255	COG0784	Response regulator, receiver
GPY20_RS06255	COG5002	protein histidine kinase activity
GPY20_RS06265	COG3706	GGDEF domain
GPY20_RS06280	COG2304	oxidoreductase activity
GPY20_RS06300	COG0714	Associated with various cellular activities
GPY20_RS06320	COG0366	Alpha amylase catalytic
GPY20_RS06330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY20_RS06335	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY20_RS06345	COG3604	Transcriptional regulator
GPY20_RS06350	COG1017	nitric oxide dioxygenase activity
GPY20_RS06350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY20_RS06355	COG3706	GGDEF domain
GPY20_RS06360	COG4681	YaeQ
GPY20_RS06365	COG1278	Cold shock
GPY20_RS06370	COG3036	rescue of stalled ribosome
GPY20_RS06390	COG0745	RESPONSE REGULATOR receiver
GPY20_RS06400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY20_RS06400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY20_RS06405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY20_RS06430	COG0798	PFAM Bile acid sodium symporter
GPY20_RS06470	COG4964	Belongs to the GSP D family
GPY20_RS06525	COG0840	transmembrane signaling receptor activity
GPY20_RS06540	COG4533	DNA binding
GPY20_RS06545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY20_RS06550	COG3835	regulator
GPY20_RS06555	COG2610	gluconate transmembrane transporter activity
GPY20_RS06560	COG1929	Belongs to the glycerate kinase type-1 family
GPY20_RS06565	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY20_RS06570	COG1473	amidohydrolase
GPY20_RS06585	COG0531	amino acid
GPY20_RS06590	COG0646	methionine synthase
GPY20_RS06590	COG1410	methionine synthase
GPY20_RS06605	COG0583	DNA-binding transcription factor activity
GPY20_RS06620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY20_RS06625	COG0363	glucosamine-6-phosphate deaminase activity
GPY20_RS06630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY20_RS06645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY20_RS06665	COG0346	lactoylglutathione lyase activity
GPY20_RS06675	COG3284	Transcriptional regulator
GPY20_RS06680	COG1012	belongs to the aldehyde dehydrogenase family
GPY20_RS06685	COG0156	8-amino-7-oxononanoate synthase activity
GPY20_RS06690	COG1063	alcohol dehydrogenase
GPY20_RS06710	COG1278	Cold shock
GPY20_RS06720	COG0582	viral genome integration into host DNA
GPY20_RS06755	COG0583	DNA-binding transcription factor activity
GPY20_RS06760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY20_RS06770	COG2084	Dehydrogenase
GPY20_RS06775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY20_RS06785	COG0242	peptide deformylase activity
GPY20_RS06795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY20_RS06810	COG2246	polysaccharide biosynthetic process
GPY20_RS06815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY20_RS06825	COG1132	(ABC) transporter
GPY20_RS06830	COG1132	(ABC) transporter
GPY20_RS06855	COG0384	phenazine biosynthesis protein PhzF
GPY20_RS06865	COG0583	DNA-binding transcription factor activity
GPY20_RS06885	COG2205	protein histidine kinase activity
GPY20_RS06895	COG0251	oxidation-reduction process
GPY20_RS06910	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY20_RS06915	COG3047	cAMP biosynthetic process
GPY20_RS06920	COG3227	Zinc metalloprotease (Elastase)
GPY20_RS06925	COG0366	Alpha amylase catalytic
GPY20_RS06950	COG1473	amidohydrolase
GPY20_RS06965	COG1584	GPR1 FUN34 yaaH family protein
GPY20_RS06975	COG0519	Catalyzes the synthesis of GMP from XMP
GPY20_RS06975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY20_RS06980	COG0517	IMP dehydrogenase activity
GPY20_RS06980	COG0516	GMP reductase activity
GPY20_RS06985	COG1570	exodeoxyribonuclease VII activity
GPY20_RS07000	COG1160	GTP binding
GPY20_RS07005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY20_RS07010	COG2976	Protein conserved in bacteria
GPY20_RS07015	COG0124	histidyl-tRNA synthetase
GPY20_RS07020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY20_RS07025	COG1426	Protein conserved in bacteria
GPY20_RS07040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY20_RS07045	COG2975	iron-sulfur cluster assembly
GPY20_RS07050	COG0633	Ferredoxin
GPY20_RS07055	COG0443	Heat shock 70 kDa protein
GPY20_RS07070	COG0822	iron-sulfur transferase activity
GPY20_RS07075	COG1104	cysteine desulfurase activity
GPY20_RS07080	COG1959	2 iron, 2 sulfur cluster binding
GPY20_RS07085	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY20_RS07090	COG0483	inositol monophosphate 1-phosphatase activity
GPY20_RS07095	COG1335	isochorismatase
GPY20_RS07100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY20_RS07105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY20_RS07110	COG1862	Preprotein translocase
GPY20_RS07115	COG0343	queuine tRNA-ribosyltransferase activity
GPY20_RS07120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY20_RS07125	COG0517	IMP dehydrogenase activity
GPY20_RS07135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY20_RS07140	COG0583	DNA-binding transcription factor activity
GPY20_RS07145	COG0450	alkyl hydroperoxide reductase
GPY20_RS07160	COG0704	Plays a role in the regulation of phosphate uptake
GPY20_RS07165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY20_RS07170	COG0581	inorganic phosphate transmembrane transporter activity
GPY20_RS07175	COG0573	inorganic phosphate transmembrane transporter activity
GPY20_RS07180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY20_RS07185	COG0248	Ppx GppA phosphatase
GPY20_RS07195	COG5002	protein histidine kinase activity
GPY20_RS07200	COG0745	RESPONSE REGULATOR receiver
GPY20_RS07205	COG2974	May be involved in recombination
GPY20_RS07215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY20_RS07220	COG0477	Major facilitator Superfamily
GPY20_RS07230	COG1595	DNA-templated transcription, initiation
GPY20_RS07240	COG3248	Nucleoside-binding outer membrane protein
GPY20_RS07245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY20_RS07250	COG0693	protein deglycase activity
GPY20_RS07255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY20_RS07265	COG2166	iron-sulfur cluster assembly
GPY20_RS07270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY20_RS07275	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY20_RS07285	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY20_RS07285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY20_RS07295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY20_RS07300	COG1074	ATP-dependent DNA helicase activity
GPY20_RS07305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY20_RS07315	COG0583	DNA-binding transcription factor activity
GPY20_RS07320	COG3141	response to X-ray
GPY20_RS07325	COG2171	N-acyltransferase activity
GPY20_RS07330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY20_RS07345	COG0189	ligase activity
GPY20_RS07345	COG0569	domain protein
GPY20_RS07360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY20_RS07365	COG2017	converts alpha-aldose to the beta-anomer
GPY20_RS07375	COG2059	Chromate
GPY20_RS07380	COG0784	Response regulator, receiver
GPY20_RS07380	COG3437	response regulator, receiver
GPY20_RS07430	COG4964	Belongs to the GSP D family
GPY20_RS07470	COG0583	DNA-binding transcription factor activity
GPY20_RS07480	COG0583	DNA-binding transcription factor activity
GPY20_RS07485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY20_RS07490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY20_RS07500	COG0560	Phosphoserine phosphatase
GPY20_RS07510	COG0813	purine-nucleoside phosphorylase activity
GPY20_RS07515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY20_RS07520	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY20_RS07525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY20_RS07530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY20_RS07555	COG0084	hydrolase, TatD family'
GPY20_RS07565	COG1115	amino acid carrier protein
GPY20_RS07580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY20_RS07600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY20_RS07605	COG0083	homoserine kinase activity
GPY20_RS07620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY20_RS07635	COG0745	RESPONSE REGULATOR receiver
GPY20_RS07645	COG0784	Response regulator, receiver
GPY20_RS07645	COG5002	protein histidine kinase activity
GPY20_RS07645	COG2198	Histidine kinase
GPY20_RS07650	COG4251	negative regulation of phosphorylation
GPY20_RS07650	COG3706	GGDEF domain
GPY20_RS07650	COG5001	Diguanylate cyclase
GPY20_RS07650	COG2203	Gaf domain
GPY20_RS07655	COG1242	4 iron, 4 sulfur cluster binding
GPY20_RS07660	COG0067	glutamate synthase
GPY20_RS07660	COG0069	glutamate synthase activity
GPY20_RS07660	COG0070	glutamate synthase
GPY20_RS07670	COG0067	glutamate synthase
GPY20_RS07670	COG0069	glutamate synthase activity
GPY20_RS07670	COG0070	glutamate synthase
GPY20_RS07675	COG0493	'glutamate synthase
GPY20_RS07695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY20_RS07700	COG2860	membrane
GPY20_RS07720	COG0583	DNA-binding transcription factor activity
GPY20_RS07725	COG0730	response to heat
GPY20_RS07735	COG0505	Belongs to the CarA family
GPY20_RS07745	COG0494	nUDIX hydrolase
GPY20_RS07750	COG0653	protein targeting
GPY20_RS07760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY20_RS07765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY20_RS07770	COG0849	cell division
GPY20_RS07775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY20_RS07780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY20_RS07785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY20_RS07790	COG0772	Belongs to the SEDS family
GPY20_RS07795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY20_RS07800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY20_RS07805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY20_RS07810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY20_RS07815	COG0768	penicillin binding
GPY20_RS07820	COG3116	cell division
GPY20_RS07825	COG0275	rRNA processing
GPY20_RS07835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY20_RS07840	COG3107	peptidoglycan biosynthetic process
GPY20_RS07845	COG0792	nuclease activity
GPY20_RS07850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY20_RS07855	COG2823	Periplasmic or secreted lipoprotein
GPY20_RS07860	COG2969	positive regulation of protein catabolic process
GPY20_RS07865	COG0625	glutathione transferase activity
GPY20_RS07870	COG2857	Cytochrome c1
GPY20_RS07875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY20_RS07880	COG0723	plastoquinol--plastocyanin reductase activity
GPY20_RS07885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY20_RS07890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY20_RS07900	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY20_RS07905	COG3105	Protein conserved in bacteria
GPY20_RS07910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY20_RS07915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY20_RS07920	COG0335	large ribosomal subunit rRNA binding
GPY20_RS07930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY20_RS07940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY20_RS07945	COG4137	Cytochrome C assembly protein
GPY20_RS07950	COG4536	flavin adenine dinucleotide binding
GPY20_RS07955	COG1854	S-ribosylhomocysteine lyase activity
GPY20_RS07970	COG0612	Peptidase, M16
GPY20_RS07975	COG1238	metal cluster binding
GPY20_RS07980	COG1063	alcohol dehydrogenase
GPY20_RS07985	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY20_RS07990	COG0511	ligase activity, forming carbon-carbon bonds
GPY20_RS07990	COG5016	pyruvate
GPY20_RS07995	COG3630	sodium ion export across plasma membrane
GPY20_RS08045	COG0527	aspartate kinase activity
GPY20_RS08050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY20_RS08060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY20_RS08065	COG1546	Belongs to the CinA family
GPY20_RS08070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY20_RS08075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY20_RS08080	COG4942	peptidase
GPY20_RS08080	COG1388	LysM domain
GPY20_RS08090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY20_RS08095	COG0585	pseudouridine synthase activity
GPY20_RS08105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY20_RS08110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY20_RS08115	COG1968	undecaprenyl-diphosphatase activity
GPY20_RS08120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY20_RS08125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY20_RS08130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY20_RS08135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPY20_RS08140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY20_RS08145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY20_RS08150	COG1610	YqeY-like protein
GPY20_RS08160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY20_RS08210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY20_RS08220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY20_RS08225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY20_RS08230	COG1349	DNA-binding transcription factor activity
GPY20_RS08235	COG0469	pyruvate kinase activity
GPY20_RS08240	COG3706	GGDEF domain
GPY20_RS08265	COG0668	transmembrane transport
GPY20_RS08270	COG0191	fructose-bisphosphate aldolase activity
GPY20_RS08275	COG0126	phosphoglycerate kinase activity
GPY20_RS08280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY20_RS08285	COG4771	TonB-dependent receptor
GPY20_RS08290	COG0583	DNA-binding transcription factor activity
GPY20_RS08295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY20_RS08315	COG2356	endonuclease I
GPY20_RS08320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY20_RS08325	COG0189	ligase activity
GPY20_RS08330	COG1678	Uncharacterized ACR, COG1678
GPY20_RS08335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY20_RS08350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY20_RS08355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY20_RS08360	COG0762	integral membrane protein
GPY20_RS08365	COG1872	DUF167
GPY20_RS08380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY20_RS08385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY20_RS08390	COG2066	Belongs to the glutaminase family
GPY20_RS08395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY20_RS08400	COG1194	a g-specific adenine glycosylase
GPY20_RS08405	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY20_RS08410	COG0741	lytic transglycosylase activity
GPY20_RS08465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY20_RS08470	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY20_RS08475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY20_RS08490	COG2967	ApaG domain
GPY20_RS08505	COG3610	response to peptide
GPY20_RS08510	COG2966	Psort location CytoplasmicMembrane, score
GPY20_RS08515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY20_RS08520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY20_RS08525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY20_RS08530	COG0142	geranyltranstransferase activity
GPY20_RS08535	COG0531	amino acid
GPY20_RS08540	COG0039	L-malate dehydrogenase activity
GPY20_RS08560	COG0589	response to stress
GPY20_RS08580	COG0312	modulator of DNA gyrase
GPY20_RS08585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY20_RS08590	COG3164	Protein of unknown function
GPY20_RS08595	COG1530	ribonuclease E activity
GPY20_RS08600	COG0424	maF-like protein
GPY20_RS08605	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY20_RS08610	COG1792	Involved in formation and maintenance of cell shape
GPY20_RS08615	COG1077	Cell shape determining protein MreB Mrl
GPY20_RS08665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY20_RS08675	COG3409	Peptidoglycan-binding domain 1 protein
GPY20_RS08675	COG3267	Type II secretory pathway component ExeA
GPY20_RS08700	COG2200	EAL domain
GPY20_RS08700	COG2199	diguanylate cyclase activity
GPY20_RS08705	COG0629	single-stranded DNA binding
GPY20_RS08720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY20_RS08730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY20_RS08735	COG0527	aspartate kinase activity
GPY20_RS08740	COG1410	methionine synthase
GPY20_RS08740	COG0646	methionine synthase
GPY20_RS08805	COG0175	sulfate reduction
GPY20_RS08835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY20_RS08840	COG0735	belongs to the Fur family
GPY20_RS08850	COG0166	Belongs to the GPI family
GPY20_RS08855	COG0432	Pfam Uncharacterised protein family UPF0047
GPY20_RS08860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY20_RS08865	COG0305	Participates in initiation and elongation during chromosome replication
GPY20_RS08875	COG0359	binds to the 23S rRNA
GPY20_RS08885	COG2965	DNA replication, synthesis of RNA primer
GPY20_RS08890	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY20_RS08900	COG2906	2 iron, 2 sulfur cluster binding
GPY20_RS08910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY20_RS08915	COG0049	tRNA binding
GPY20_RS08925	COG2168	tRNA wobble position uridine thiolation
GPY20_RS08930	COG2923	Belongs to the DsrF TusC family
GPY20_RS08940	COG2964	Protein conserved in bacteria
GPY20_RS08945	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY20_RS08955	COG2900	Belongs to the SlyX family
GPY20_RS08960	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY20_RS08965	COG0330	HflC and HflK could
GPY20_RS08970	COG0330	HflC and HflK could
GPY20_RS08975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY20_RS08980	COG1923	regulation of RNA biosynthetic process
GPY20_RS08985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY20_RS08990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY20_RS09000	COG0802	atpase or kinase
GPY20_RS09005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY20_RS09060	COG1162	GTPase activity
GPY20_RS09065	COG0688	phosphatidylethanolamine metabolic process
GPY20_RS09070	COG0490	domain, Protein
GPY20_RS09070	COG0471	metal ion transport
GPY20_RS09085	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY20_RS09090	COG4942	peptidase
GPY20_RS09110	COG2816	NAD+ diphosphatase activity
GPY20_RS09115	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY20_RS09120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY20_RS09125	COG0085	RNA polymerase activity
GPY20_RS09135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY20_RS09140	COG0081	regulation of translation
GPY20_RS09145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY20_RS09150	COG0250	Participates in transcription elongation, termination and antitermination
GPY20_RS09155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY20_RS09185	COG1072	(Pantothenic acid kinase))
GPY20_RS09195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY20_RS09205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY20_RS09250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY20_RS09260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY20_RS09265	COG3118	belongs to the thioredoxin family
GPY20_RS09270	COG0513	Belongs to the DEAD box helicase family
GPY20_RS09275	COG0248	Ppx GppA phosphatase
GPY20_RS09280	COG2198	Histidine kinase
GPY20_RS09280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY20_RS09280	COG0784	Response regulator, receiver
GPY20_RS09280	COG2205	protein histidine kinase activity
GPY20_RS09285	COG2814	Major facilitator Superfamily
GPY20_RS09300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY20_RS09305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY20_RS09310	COG0511	ligase activity, forming carbon-carbon bonds
GPY20_RS09315	COG0439	Biotin carboxylase
GPY20_RS09320	COG2264	protein methyltransferase activity
GPY20_RS09325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY20_RS09330	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY20_RS09335	COG0840	transmembrane signaling receptor activity
GPY20_RS09340	COG0789	Transcriptional regulator
GPY20_RS09350	COG0138	bifunctional purine biosynthesis protein purh
GPY20_RS09355	COG0151	Belongs to the GarS family
GPY20_RS09365	COG0776	regulation of translation
GPY20_RS09370	COG1253	flavin adenine dinucleotide binding
GPY20_RS09375	COG0668	transmembrane transport
GPY20_RS09380	COG3068	Protein conserved in bacteria
GPY20_RS09385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY20_RS09390	COG1573	uracil-dna glycosylase
GPY20_RS09395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY20_RS09400	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GPY20_RS09410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY20_RS09440	COG0367	asparagine synthase
GPY20_RS09470	COG2089	acid synthase
GPY20_RS09480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY20_RS09490	COG1560	Kdo2-lipid A biosynthetic process
GPY20_RS09500	COG0859	PFAM glycosyl transferase family 9
GPY20_RS09505	COG0859	PFAM glycosyl transferase family 9
GPY20_RS09510	COG1519	Transferase
GPY20_RS09515	COG0438	transferase activity, transferring glycosyl groups
GPY20_RS09525	COG0859	PFAM glycosyl transferase family 9
GPY20_RS09530	COG0463	Glycosyl transferase, family 2
GPY20_RS09535	COG0438	transferase activity, transferring glycosyl groups
GPY20_RS09540	COG0438	transferase activity, transferring glycosyl groups
GPY20_RS09545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY20_RS09560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY20_RS09570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY20_RS09595	COG1309	transcriptional regulator
GPY20_RS09600	COG1560	Kdo2-lipid A biosynthetic process
GPY20_RS09605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY20_RS09610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY20_RS09615	COG1561	YicC-like family, N-terminal region
GPY20_RS09635	COG0270	DNA (cytosine-5-)-methyltransferase activity
GPY20_RS09680	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY20_RS09685	COG1120	ATPase activity
GPY20_RS09690	COG1132	(ABC) transporter
GPY20_RS09705	COG0514	ATP-dependent DNA helicase (RecQ)
GPY20_RS09710	COG2962	Rard protein
GPY20_RS09720	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS09725	COG0405	Gamma-glutamyltransferase
GPY20_RS09730	COG0210	DNA helicase
GPY20_RS09765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY20_RS09770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY20_RS09810	COG3550	peptidyl-serine autophosphorylation
GPY20_RS09855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY20_RS09860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY20_RS09870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY20_RS09880	COG0747	negative chemotaxis
GPY20_RS09885	COG4172	Belongs to the ABC transporter superfamily
GPY20_RS09920	COG0210	DNA helicase
GPY20_RS09930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY20_RS09935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY20_RS09940	COG2960	long-chain fatty acid transporting porin activity
GPY20_RS09950	COG0583	DNA-binding transcription factor activity
GPY20_RS09995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY20_RS10005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY20_RS10010	COG0408	coproporphyrinogen oxidase activity
GPY20_RS10025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY20_RS10030	COG0551	DNA topoisomerase type I activity
GPY20_RS10035	COG2922	Belongs to the Smg family
GPY20_RS10040	COG0758	DNA mediated transformation
GPY20_RS10045	COG1652	LysM domain
GPY20_RS10050	COG0242	peptide deformylase activity
GPY20_RS10060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY20_RS10060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY20_RS10065	COG0569	domain protein
GPY20_RS10070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY20_RS10080	COG1272	protein, Hemolysin III
GPY20_RS10085	COG4326	sporulation control protein
GPY20_RS10095	COG3084	Protein conserved in bacteria
GPY20_RS10105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY20_RS10110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY20_RS10115	COG0204	Acyl-transferase
GPY20_RS10120	COG0606	chelatase, subunit chli
GPY20_RS10130	COG3978	acetolactate synthase activity
GPY20_RS10135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY20_RS10150	COG0604	alcohol dehydrogenase
GPY20_RS10175	COG2119	membrane
GPY20_RS10180	COG0752	glycyl-tRNA synthetase alpha subunit
GPY20_RS10185	COG0751	glycine-tRNA ligase activity
GPY20_RS10195	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY20_RS10200	COG0187	DNA topoisomerase II activity
GPY20_RS10205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY20_RS10210	COG0592	DNA-directed DNA polymerase activity
GPY20_RS10215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY20_RS10230	COG1126	abc transporter atp-binding protein
GPY20_RS10235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY20_RS10245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY20_RS10250	COG0706	membrane insertase activity
GPY20_RS10255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY20_RS10260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY20_RS10265	COG0445	tRNA wobble uridine modification
GPY20_RS10270	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY20_RS10275	COG1192	Involved in chromosome partitioning
GPY20_RS10280	COG1475	DNA binding
GPY20_RS10285	COG3312	ion transport
GPY20_RS10290	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY20_RS10300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY20_RS10305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY20_RS10315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY20_RS10320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY20_RS10325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY20_RS10335	COG0765	amino acid transport
GPY20_RS10340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY20_RS10345	COG2814	Major facilitator Superfamily
GPY20_RS10350	COG0583	DNA-binding transcription factor activity
GPY20_RS10355	COG0183	Belongs to the thiolase family
GPY20_RS10365	COG1739	Uncharacterized protein family UPF0029
GPY20_RS10370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY20_RS10425	COG2132	Multicopper oxidase
GPY20_RS10430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY20_RS10435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY20_RS10440	COG0352	thiamine-phosphate diphosphorylase activity
GPY20_RS10445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY20_RS10450	COG2104	thiamine diphosphate biosynthetic process
GPY20_RS10450	COG2022	thiamine diphosphate biosynthetic process
GPY20_RS10460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY20_RS10465	COG4175	Glycine betaine
GPY20_RS10465	COG0517	IMP dehydrogenase activity
GPY20_RS10495	COG0006	proline dipeptidase activity
GPY20_RS10495	COG0006	proline dipeptidase activity
GPY20_RS10515	COG1522	sequence-specific DNA binding
GPY20_RS10520	COG5001	Diguanylate cyclase
GPY20_RS10520	COG5002	protein histidine kinase activity
GPY20_RS10525	COG0742	ribosomal rna small subunit methyltransferase
GPY20_RS10540	COG0589	response to stress
GPY20_RS10545	COG1528	Iron-storage protein
GPY20_RS10555	COG2081	HI0933 family
GPY20_RS10560	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY20_RS10565	COG1129	ABC transporter
GPY20_RS10570	COG1879	ABC-type sugar transport system periplasmic component
GPY20_RS10575	COG1069	ribulokinase activity
GPY20_RS10580	COG0235	Class ii aldolase
GPY20_RS10585	COG2160	L-arabinose isomerase activity
GPY20_RS10610	COG1322	Protein conserved in bacteria
GPY20_RS10615	COG2226	methyltransferase
GPY20_RS10620	COG3165	ubiquinone biosynthetic process from chorismate
GPY20_RS10625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY20_RS10635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY20_RS10640	COG0805	protein transport
GPY20_RS10645	COG0084	hydrolase, TatD family'
GPY20_RS10655	COG0456	acetyltransferase
GPY20_RS10660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY20_RS10660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY20_RS10665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY20_RS10690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY20_RS10695	COG3071	HemY protein
GPY20_RS10700	COG2959	enzyme of heme biosynthesis
GPY20_RS10715	COG3072	Adenylate cyclase
GPY20_RS10730	COG0019	diaminopimelate decarboxylase activity
GPY20_RS10735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY20_RS10745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY20_RS10750	COG1011	Hydrolase
GPY20_RS10755	COG3287	FIST C domain
GPY20_RS10755	COG2199	diguanylate cyclase activity
GPY20_RS10755	COG2200	EAL domain
GPY20_RS10775	COG0561	phosphatase activity
GPY20_RS10780	COG2267	carboxylic ester hydrolase activity
GPY20_RS10785	COG1280	lysine exporter protein (LysE YggA)
GPY20_RS10790	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY20_RS10795	COG0640	Transcriptional regulator
GPY20_RS10800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY20_RS10815	COG0783	Belongs to the Dps family
GPY20_RS10845	COG2095	MarC family integral membrane protein
GPY20_RS10855	COG0742	ribosomal rna small subunit methyltransferase
GPY20_RS10860	COG0552	protein localization to endoplasmic reticulum
GPY20_RS10865	COG2884	Cell division ATP-binding protein ftsE
GPY20_RS10870	COG2177	Part of the ABC transporter FtsEX involved in
GPY20_RS10875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY20_RS10885	COG0705	Rhomboid family
GPY20_RS10890	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY20_RS10895	COG3161	chorismate lyase activity
GPY20_RS10900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY20_RS10905	COG2937	Belongs to the GPAT DAPAT family
GPY20_RS10910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY20_RS10915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY20_RS10925	COG0534	Mate efflux family protein
GPY20_RS10945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY20_RS10960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY20_RS11020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY20_RS11025	COG5001	Diguanylate cyclase
GPY20_RS11025	COG3300	MHYT domain
GPY20_RS11030	COG2204	response regulator
GPY20_RS11035	COG3852	Histidine kinase
GPY20_RS11045	COG0174	glutamine synthetase
GPY20_RS11070	COG1490	D-aminoacyl-tRNA deacylase activity
GPY20_RS11075	COG0456	acetyltransferase
GPY20_RS11080	COG2982	Protein involved in outer membrane biogenesis
GPY20_RS11085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY20_RS11090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY20_RS11095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY20_RS11100	COG3031	protein transport across the cell outer membrane
GPY20_RS11110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY20_RS11115	COG1459	type II secretion system
GPY20_RS11120	COG2165	general secretion pathway protein
GPY20_RS11125	COG2165	general secretion pathway protein
GPY20_RS11130	COG2165	general secretion pathway protein
GPY20_RS11135	COG4795	General secretion pathway protein
GPY20_RS11140	COG3156	type II secretion system protein K
GPY20_RS11145	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY20_RS11150	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY20_RS11160	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY20_RS11165	COG0494	nUDIX hydrolase
GPY20_RS11170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY20_RS11170	COG0316	Belongs to the HesB IscA family
GPY20_RS11175	COG1040	competence protein
GPY20_RS11190	COG2183	response to ionizing radiation
GPY20_RS11200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY20_RS11205	COG1609	Transcriptional regulator
GPY20_RS11210	COG0129	dihydroxy-acid dehydratase activity
GPY20_RS11215	COG3265	gluconokinase activity
GPY20_RS11220	COG2610	gluconate transmembrane transporter activity
GPY20_RS11225	COG0800	Aldolase
GPY20_RS11230	COG0745	RESPONSE REGULATOR receiver
GPY20_RS11235	COG2205	protein histidine kinase activity
GPY20_RS11240	COG2233	PERMEase
GPY20_RS11245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY20_RS11250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY20_RS11255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY20_RS11265	COG0194	GDP metabolic process
GPY20_RS11270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY20_RS11275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY20_RS11285	COG3263	regulation of cellular component size
GPY20_RS11295	COG4232	protein-disulfide reductase activity
GPY20_RS11305	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY20_RS11310	COG0540	Belongs to the ATCase OTCase family
GPY20_RS11315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY20_RS11330	COG1288	antiporter activity
GPY20_RS11335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY20_RS11340	COG1027	Aspartate ammonia-lyase
GPY20_RS11345	COG3706	GGDEF domain
GPY20_RS11350	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY20_RS11355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY20_RS11360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GPY20_RS11365	COG2205	protein histidine kinase activity
GPY20_RS11370	COG0745	RESPONSE REGULATOR receiver
GPY20_RS11380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY20_RS11385	COG0205	6-phosphofructokinase activity
GPY20_RS11390	COG1494	fructose-1,6-bisphosphatase
GPY20_RS11400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY20_RS11405	COG0460	homoserine dehydrogenase
GPY20_RS11405	COG0527	aspartate kinase activity
GPY20_RS11410	COG0626	cystathionine gamma-synthase activity
GPY20_RS11420	COG0281	malic enzyme
GPY20_RS11425	COG0254	rRNA binding
GPY20_RS11430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY20_RS11435	COG1609	Transcriptional regulator
GPY20_RS11445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY20_RS11450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY20_RS11455	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY20_RS11460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY20_RS11470	COG0149	triose-phosphate isomerase activity
GPY20_RS11495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY20_RS11500	COG0459	protein refolding
GPY20_RS11505	COG1119	ATPase activity
GPY20_RS11515	COG1285	pathogenesis
GPY20_RS11520	COG1509	lysine 2,3-aminomutase activity
GPY20_RS11525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY20_RS11530	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY20_RS11535	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY20_RS11540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY20_RS11545	COG1053	succinate dehydrogenase
GPY20_RS11550	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY20_RS11555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY20_RS11560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY20_RS11565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY20_RS11570	COG1045	serine acetyltransferase
GPY20_RS11575	COG1695	Transcriptional regulator
GPY20_RS11580	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY20_RS11585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY20_RS11590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY20_RS11595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY20_RS11605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY20_RS11605	COG0165	Argininosuccinate lyase
GPY20_RS11615	COG0678	peroxiredoxin activity
GPY20_RS11615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY20_RS11625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY20_RS11660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY20_RS11670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY20_RS11675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY20_RS11685	COG0180	Tryptophanyl-tRNA synthetase
GPY20_RS11695	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY20_RS11705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY20_RS11715	COG1012	belongs to the aldehyde dehydrogenase family
GPY20_RS11725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY20_RS11730	COG3954	Phosphoribulokinase
GPY20_RS11740	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY20_RS11750	COG0488	(ABC) transporter
GPY20_RS11755	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY20_RS11765	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GPY20_RS11770	COG1047	Peptidyl-prolyl cis-trans
GPY20_RS11780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY20_RS11785	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY20_RS11790	COG3083	sulfuric ester hydrolase activity
GPY20_RS11795	COG0557	exoribonuclease II activity
GPY20_RS11800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY20_RS11805	COG0051	transcription antitermination factor activity, RNA binding
GPY20_RS11810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY20_RS11815	COG0088	Forms part of the polypeptide exit tunnel
GPY20_RS11820	COG0089	rRNA binding
GPY20_RS11830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY20_RS11835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY20_RS11850	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY20_RS11860	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY20_RS11865	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY20_RS11870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY20_RS11875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY20_RS11880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY20_RS11885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY20_RS11890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY20_RS11900	COG1841	ribosomal large subunit assembly
GPY20_RS11910	COG0201	protein transport
GPY20_RS11925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY20_RS11930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY20_RS11935	COG0202	RNA polymerase activity
GPY20_RS11940	COG0203	ribosomal protein L17
GPY20_RS11950	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY20_RS11955	COG3061	Opacity-associated protein A
GPY20_RS11960	COG0697	spore germination
GPY20_RS11965	COG2153	protein acetylation
GPY20_RS11970	COG0513	Belongs to the DEAD box helicase family
GPY20_RS11980	COG0737	Belongs to the 5'-nucleotidase family
GPY20_RS11985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY20_RS11985	COG1648	precorrin-2 dehydrogenase activity
GPY20_RS11990	COG0175	sulfate reduction
GPY20_RS11995	COG2895	sulfate adenylyltransferase (ATP) activity
GPY20_RS12000	COG0471	metal ion transport
GPY20_RS12000	COG0490	domain, Protein
GPY20_RS12005	COG0529	Catalyzes the synthesis of activated sulfate
GPY20_RS12025	COG1136	(ABC) transporter
GPY20_RS12025	COG0577	efflux transmembrane transporter activity
GPY20_RS12040	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY20_RS12045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY20_RS12050	COG0729	surface antigen
GPY20_RS12060	COG2105	PFAM AIG2 family protein
GPY20_RS12070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY20_RS12075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY20_RS12080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY20_RS12085	COG0163	prenyltransferase activity
GPY20_RS12090	COG4143	(ABC) transporter
GPY20_RS12095	COG1178	ABC-type Fe3 transport system permease component
GPY20_RS12100	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY20_RS12105	COG3028	Belongs to the UPF0307 family
GPY20_RS12110	COG0312	modulator of DNA gyrase
GPY20_RS12115	COG2239	Acts as a magnesium transporter
GPY20_RS12120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY20_RS12130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY20_RS12135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY20_RS12145	COG1137	ATPase activity
GPY20_RS12150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY20_RS12160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GPY20_RS12165	COG0517	IMP dehydrogenase activity
GPY20_RS12165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY20_RS12175	COG1127	ABC transporter
GPY20_RS12180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY20_RS12185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY20_RS12190	COG2854	intermembrane phospholipid transfer
GPY20_RS12195	COG3113	response to antibiotic
GPY20_RS12200	COG5007	Belongs to the BolA IbaG family
GPY20_RS12205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY20_RS12210	COG0204	Acyl-transferase
GPY20_RS12215	COG0251	oxidation-reduction process
GPY20_RS12220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY20_RS12225	COG0540	Belongs to the ATCase OTCase family
GPY20_RS12230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY20_RS12235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY20_RS12245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY20_RS12255	COG0564	pseudouridine synthase activity
GPY20_RS12260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY20_RS12265	COG0525	valine-tRNA ligase activity
GPY20_RS12280	COG0795	lipopolysaccharide-transporting ATPase activity
GPY20_RS12285	COG0795	lipopolysaccharide-transporting ATPase activity
GPY20_RS12295	COG3706	GGDEF domain
GPY20_RS12315	COG2203	Gaf domain
GPY20_RS12315	COG2200	EAL domain
GPY20_RS12315	COG2199	diguanylate cyclase activity
GPY20_RS12325	COG3437	response regulator, receiver
GPY20_RS12375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY20_RS12380	COG0473	3-isopropylmalate dehydrogenase activity
GPY20_RS12385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY20_RS12405	COG0583	DNA-binding transcription factor activity
GPY20_RS12410	COG1022	Amp-dependent synthetase and ligase
GPY20_RS12415	COG0028	Belongs to the TPP enzyme family
GPY20_RS12420	COG0440	acetolactate synthase activity
GPY20_RS12425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY20_RS12435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY20_RS12445	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY20_RS12455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY20_RS12460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY20_RS12475	COG0354	folic acid binding
GPY20_RS12480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY20_RS12490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY20_RS12495	COG1595	DNA-templated transcription, initiation
GPY20_RS12510	COG3086	response to oxidative stress
GPY20_RS12515	COG0481	GTPase activity
GPY20_RS12520	COG0681	Belongs to the peptidase S26 family
GPY20_RS12525	COG0571	ribonuclease III activity
GPY20_RS12530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY20_RS12535	COG1381	Involved in DNA repair and RecF pathway recombination
GPY20_RS12540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY20_RS12545	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY20_RS12555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY20_RS12560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY20_RS12565	COG3956	TIGRFAM MazG family protein
GPY20_RS12570	COG0504	CTP synthase activity
GPY20_RS12575	COG0148	phosphopyruvate hydratase activity
GPY20_RS12580	COG0617	tRNA 3'-terminal CCA addition
GPY20_RS12585	COG3409	Peptidoglycan-binding domain 1 protein
GPY20_RS12585	COG3267	Type II secretory pathway component ExeA
GPY20_RS12595	COG4991	sh3 domain protein
GPY20_RS12600	COG0306	phosphate transporter
GPY20_RS12605	COG1392	Phosphate transport regulator
GPY20_RS12610	COG3025	triphosphatase activity
GPY20_RS12615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY20_RS12625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY20_RS12630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY20_RS12630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY20_RS12635	COG1538	Outer membrane efflux protein
GPY20_RS12640	COG0494	nUDIX hydrolase
GPY20_RS12645	COG3151	Protein conserved in bacteria
GPY20_RS12655	COG3150	esterase
GPY20_RS12660	COG0187	DNA topoisomerase II activity
GPY20_RS12665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY20_RS12670	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY20_RS12675	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY20_RS12690	COG1459	type II secretion system
GPY20_RS12695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY20_RS12715	COG0716	FMN binding
GPY20_RS12720	COG4974	Belongs to the 'phage' integrase family
GPY20_RS12725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY20_RS12730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY20_RS12735	COG2186	Transcriptional regulator
GPY20_RS12740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY20_RS12745	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY20_RS12750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY20_RS12765	COG0288	reversible hydration of carbon dioxide
GPY20_RS12770	COG1131	(ABC) transporter
GPY20_RS12775	COG0842	Transport permease protein
GPY20_RS12780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY20_RS12785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY20_RS12790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY20_RS12800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY20_RS12805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY20_RS12810	COG1489	DNA binding
GPY20_RS12815	COG1643	Atp-dependent helicase
GPY20_RS12820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY20_RS12825	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY20_RS12830	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY20_RS12835	COG3112	Uncharacterised protein family (UPF0231)
GPY20_RS12840	COG0347	Belongs to the P(II) protein family
GPY20_RS12845	COG0004	ammonium transporteR
GPY20_RS12850	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY20_RS12860	COG3842	ATPase activity
GPY20_RS12865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY20_RS12880	COG2971	BadF BadG BcrA BcrD
GPY20_RS12890	COG4608	Belongs to the ABC transporter superfamily
GPY20_RS12895	COG0444	Belongs to the ABC transporter superfamily
GPY20_RS12900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY20_RS12910	COG0747	negative chemotaxis
GPY20_RS12925	COG0628	permease
GPY20_RS12935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY20_RS12940	COG0316	Belongs to the HesB IscA family
GPY20_RS12955	COG0739	heme binding
GPY20_RS12960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY20_RS12970	COG2239	Acts as a magnesium transporter
GPY20_RS12975	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY20_RS12980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY20_RS12985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY20_RS12990	COG1534	Rna-binding protein
GPY20_RS13000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY20_RS13005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY20_RS13010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY20_RS13015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY20_RS13030	COG0779	Required for maturation of 30S ribosomal subunits
GPY20_RS13035	COG0195	Participates in both transcription termination and antitermination
GPY20_RS13045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY20_RS13050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY20_RS13075	COG0534	Mate efflux family protein
GPY20_RS13100	COG3153	acetyltransferase
GPY20_RS13120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY20_RS13125	COG0513	Belongs to the DEAD box helicase family
GPY20_RS13145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY20_RS13150	COG2204	response regulator
GPY20_RS13160	COG0667	Aldo Keto reductase
GPY20_RS13170	COG3066	DNA modification
GPY20_RS13175	COG0494	nUDIX hydrolase
GPY20_RS13185	COG0730	response to heat
GPY20_RS13200	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY20_RS13205	COG0583	DNA-binding transcription factor activity
GPY20_RS13210	COG0640	Transcriptional regulator
GPY20_RS13220	COG0728	peptidoglycan biosynthetic process
GPY20_RS13225	COG0196	riboflavin kinase activity
GPY20_RS13230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY20_RS13235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY20_RS13240	COG1047	Peptidyl-prolyl cis-trans
GPY20_RS13245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY20_RS13250	COG1966	Carbon starvation protein
GPY20_RS13265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY20_RS13270	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY20_RS13280	COG3279	Response regulator of the LytR AlgR family
GPY20_RS13285	COG3275	phosphorelay sensor kinase activity
GPY20_RS13290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY20_RS13295	COG1605	Chorismate mutase
GPY20_RS13295	COG0287	Prephenate dehydrogenase
GPY20_RS13305	COG0488	(ABC) transporter
GPY20_RS13320	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY20_RS13325	COG5001	Diguanylate cyclase
GPY20_RS13330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY20_RS13335	COG1605	Chorismate mutase
GPY20_RS13335	COG0077	Prephenate dehydratase
GPY20_RS13340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY20_RS13345	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY20_RS13350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY20_RS13355	COG0564	pseudouridine synthase activity
GPY20_RS13365	COG0542	response to heat
GPY20_RS13375	COG0590	tRNA wobble adenosine to inosine editing
GPY20_RS13380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY20_RS13385	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GPY20_RS13465	COG0271	Belongs to the BolA IbaG family
GPY20_RS13470	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY20_RS13475	COG1805	sodium ion transport
GPY20_RS13485	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY20_RS13490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY20_RS13495	COG2871	sodium ion transport
GPY20_RS13500	COG1477	protein flavinylation
GPY20_RS13515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY20_RS13525	COG5001	Diguanylate cyclase
GPY20_RS13525	COG4251	negative regulation of phosphorylation
GPY20_RS13525	COG3706	GGDEF domain
GPY20_RS13525	COG2203	Gaf domain
GPY20_RS13530	COG0733	neurotransmitter:sodium symporter activity
GPY20_RS13540	COG0189	ligase activity
GPY20_RS13545	COG4067	protein conserved in archaea
GPY20_RS13545	COG0189	ligase activity
GPY20_RS13550	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY20_RS13555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY20_RS13560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY20_RS13570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY20_RS13580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY20_RS13585	COG2252	PERMEase
GPY20_RS13590	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY20_RS13605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY20_RS13610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY20_RS13615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY20_RS13620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY20_RS13620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY20_RS13640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY20_RS13645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY20_RS13650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY20_RS13660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY20_RS13665	COG0024	Methionine aminopeptidase
GPY20_RS13690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY20_RS13695	COG0575	Belongs to the CDS family
GPY20_RS13700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY20_RS13705	COG0750	zinc metalloprotease
GPY20_RS13715	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY20_RS13720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY20_RS13725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY20_RS13735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY20_RS13745	COG0587	DNA-directed DNA polymerase activity
GPY20_RS13750	COG0825	malonyl-CoA metabolic process
GPY20_RS13755	COG0037	tRNA processing
GPY20_RS13765	COG0347	Belongs to the P(II) protein family
GPY20_RS13780	COG0741	lytic transglycosylase activity
GPY20_RS13780	COG1388	LysM domain
GPY20_RS13790	COG2226	methyltransferase
GPY20_RS13795	COG0328	RNA-DNA hybrid ribonuclease activity
GPY20_RS13800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY20_RS13810	COG1960	acyl-CoA dehydrogenase activity
GPY20_RS13815	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY20_RS13820	COG0121	glutamine amidotransferase
GPY20_RS13825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY20_RS13830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY20_RS13835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY20_RS13840	COG1187	pseudouridine synthase activity
GPY20_RS13845	COG2840	Smr protein MutS2
GPY20_RS13875	COG2217	Heavy metal translocating P-type atpase
GPY20_RS13875	COG2608	mercury ion transmembrane transporter activity
GPY20_RS13880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY20_RS13975	COG4695	Portal protein
GPY20_RS14005	COG2747	anti-sigma28 factor FlgM
GPY20_RS14015	COG0835	chemotaxis
GPY20_RS14015	COG0784	Response regulator, receiver
GPY20_RS14020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY20_RS14025	COG1815	bacterial-type flagellum-dependent cell motility
GPY20_RS14030	COG1558	bacterial-type flagellum-dependent cell motility
GPY20_RS14035	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY20_RS14040	COG1749	Flagellar hook protein flgE
GPY20_RS14045	COG4787	bacterial-type flagellum-dependent cell motility
GPY20_RS14050	COG4786	Flagellar basal body rod
GPY20_RS14055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY20_RS14060	COG1706	bacterial-type flagellum-dependent cell motility
GPY20_RS14065	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY20_RS14065	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY20_RS14080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY20_RS14180	COG0193	aminoacyl-tRNA hydrolase activity
GPY20_RS14185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY20_RS14195	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY20_RS14200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY20_RS14205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY20_RS14210	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY20_RS14215	COG3094	Invasion gene expression up-regulator, SirB
GPY20_RS14220	COG2912	Transglutaminase-like superfamily
GPY20_RS14230	COG0737	Belongs to the 5'-nucleotidase family
GPY20_RS14240	COG2233	PERMEase
GPY20_RS14260	COG1393	Belongs to the ArsC family
GPY20_RS14265	COG4783	chaperone-mediated protein folding
GPY20_RS14285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY20_RS14290	COG2716	regulation of RNA biosynthetic process
GPY20_RS14295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY20_RS14300	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY20_RS14310	COG1876	peptidase activity
GPY20_RS14315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY20_RS14320	COG1393	Belongs to the ArsC family
GPY20_RS14340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY20_RS14360	COG2837	iron assimilation
GPY20_RS14370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY20_RS14375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY20_RS14380	COG1334	flagellar protein FlaG
GPY20_RS14385	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY20_RS14395	COG1516	flagellar protein fliS
GPY20_RS14400	COG2204	response regulator
GPY20_RS14405	COG4191	Histidine kinase
GPY20_RS14410	COG2204	response regulator
GPY20_RS14415	COG1677	Flagellar hook-basal body complex protein FliE
GPY20_RS14425	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY20_RS14475	COG1987	bacterial-type flagellum assembly
GPY20_RS14495	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY20_RS14500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY20_RS14505	COG0583	DNA-binding transcription factor activity
GPY20_RS14510	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS14515	COG2860	membrane
GPY20_RS14520	COG3101	peptidyl-lysine hydroxylation
GPY20_RS14535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY20_RS14535	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY20_RS14540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY20_RS14545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY20_RS14550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY20_RS14555	COG0735	belongs to the Fur family
GPY20_RS14565	COG0583	DNA-binding transcription factor activity
GPY20_RS14570	COG1380	Effector of murein hydrolase LrgA
GPY20_RS14575	COG1346	cytolysis
GPY20_RS14590	COG0596	Alpha beta hydrolase
GPY20_RS14595	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY20_RS14600	COG0033	Phosphoglucomutase
GPY20_RS14610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY20_RS14620	COG2009	succinate dehydrogenase
GPY20_RS14625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY20_RS14640	COG0567	Dehydrogenase, E1 component
GPY20_RS14645	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY20_RS14660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY20_RS14665	COG1121	(ABC) transporter
GPY20_RS14670	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY20_RS14680	COG1918	ferrous iron import across plasma membrane
GPY20_RS14705	COG3102	Protein conserved in bacteria
GPY20_RS14715	COG2062	phosphohistidine phosphatase, SixA
GPY20_RS14730	COG0455	bacterial-type flagellum organization
GPY20_RS14745	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY20_RS14750	COG0643	Histidine kinase
GPY20_RS14750	COG2198	Histidine kinase
GPY20_RS14755	COG2201	protein-glutamate methylesterase activity
GPY20_RS14760	COG1192	Involved in chromosome partitioning
GPY20_RS14770	COG0835	chemotaxis
GPY20_RS14780	COG4133	protoheme IX ABC transporter activity
GPY20_RS14785	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY20_RS14790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY20_RS14795	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY20_RS14800	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY20_RS14805	COG1138	Cytochrome C-type biogenesis protein
GPY20_RS14810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY20_RS14825	COG2853	Lipoprotein
GPY20_RS14845	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY20_RS14850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY20_RS14855	COG3384	dioxygenase
GPY20_RS14880	COG0667	Aldo Keto reductase
GPY20_RS14895	COG0583	DNA-binding transcription factor activity
GPY20_RS14900	COG2159	amidohydrolase
GPY20_RS14905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY20_RS14945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY20_RS14960	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY20_RS14970	COG1448	Aminotransferase
GPY20_RS14985	COG3083	sulfuric ester hydrolase activity
GPY20_RS14995	COG3081	Nucleoid-associated protein
GPY20_RS15005	COG1757	Na H antiporter
GPY20_RS15010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY20_RS15015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY20_RS15020	COG2095	MarC family integral membrane protein
GPY20_RS15025	COG1012	belongs to the aldehyde dehydrogenase family
GPY20_RS15025	COG1454	alcohol dehydrogenase
GPY20_RS15035	COG0659	secondary active sulfate transmembrane transporter activity
GPY20_RS15045	COG1530	ribonuclease E activity
GPY20_RS15050	COG0564	pseudouridine synthase activity
GPY20_RS15055	COG0424	maF-like protein
GPY20_RS15060	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY20_RS15070	COG0416	fatty acid biosynthetic process
GPY20_RS15075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY20_RS15095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY20_RS15100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY20_RS15105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY20_RS15110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY20_RS15115	COG0470	DNA polymerase III
GPY20_RS15120	COG0084	hydrolase, TatD family'
GPY20_RS15125	COG1263	PTS System
GPY20_RS15125	COG2190	(PTS) system
GPY20_RS15125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY20_RS15135	COG1263	PTS System
GPY20_RS15135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY20_RS15155	COG0733	neurotransmitter:sodium symporter activity
GPY20_RS15170	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY20_RS15175	COG0469	pyruvate kinase activity
GPY20_RS15180	COG1940	carbohydrate kinase activity
GPY20_RS15185	COG0784	Response regulator, receiver
GPY20_RS15185	COG0835	chemotaxis
GPY20_RS15190	COG0587	DNA-directed DNA polymerase activity
GPY20_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS15210	COG0616	signal peptide processing
GPY20_RS15250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY20_RS15255	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY20_RS15260	COG0436	Aminotransferase
GPY20_RS15265	COG1169	isochorismate synthase
GPY20_RS15270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY20_RS15275	COG0596	Alpha beta hydrolase
GPY20_RS15280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY20_RS15285	COG1441	menaquinone biosynthetic process
GPY20_RS15300	COG2855	membrane
GPY20_RS15305	COG0477	Major facilitator Superfamily
GPY20_RS15325	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GPY20_RS15330	COG1388	LysM domain
GPY20_RS15330	COG0741	lytic transglycosylase activity
GPY20_RS15350	COG1815	bacterial-type flagellum-dependent cell motility
GPY20_RS15355	COG1558	bacterial-type flagellum-dependent cell motility
GPY20_RS15360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY20_RS15365	COG1749	Flagellar hook protein flgE
GPY20_RS15375	COG4786	Flagellar basal body rod
GPY20_RS15380	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY20_RS15385	COG1706	bacterial-type flagellum-dependent cell motility
GPY20_RS15395	COG4786	Flagellar basal body rod
GPY20_RS15395	COG1256	bacterial-type flagellum assembly
GPY20_RS15415	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GPY20_RS15465	COG0702	epimerase
GPY20_RS15470	COG3015	lipoprotein NlpE involved in copper resistance
GPY20_RS15480	COG1360	Flagellar Motor Protein
GPY20_RS15485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY20_RS15490	COG1191	sigma factor activity
GPY20_RS15495	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY20_RS15515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY20_RS15520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY20_RS15535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY20_RS15545	COG1987	bacterial-type flagellum assembly
GPY20_RS15565	COG2885	chlorophyll binding
GPY20_RS15570	COG2204	response regulator
GPY20_RS15585	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY20_RS15610	COG1522	sequence-specific DNA binding
GPY20_RS15615	COG1946	Acyl-CoA thioesterase
GPY20_RS15620	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY20_RS15635	COG2203	Gaf domain
GPY20_RS15635	COG2199	diguanylate cyclase activity
GPY20_RS15665	COG0431	NADPH-dependent FMN reductase
GPY20_RS15670	COG0697	spore germination
GPY20_RS15680	COG1278	Cold shock
GPY20_RS15705	COG2207	Transcriptional regulator
GPY20_RS15710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY20_RS15715	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY20_RS15715	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY20_RS15720	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY20_RS15725	COG1881	PFAM PEBP family protein
GPY20_RS15730	COG2207	Transcriptional regulator
GPY20_RS15735	COG1733	regulation of RNA biosynthetic process
GPY20_RS15740	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS15770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY20_RS15775	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY20_RS15790	COG0642	Histidine kinase
GPY20_RS15795	COG0745	RESPONSE REGULATOR receiver
GPY20_RS15800	COG0671	phosphoesterase, PA-phosphatase related
GPY20_RS15810	COG0513	Belongs to the DEAD box helicase family
GPY20_RS15815	COG1368	sulfuric ester hydrolase activity
GPY20_RS15820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY20_RS15825	COG2194	sulfuric ester hydrolase activity
GPY20_RS15870	COG2863	cytochrome
GPY20_RS15875	COG3258	Cytochrome c
GPY20_RS15890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY20_RS15895	COG1271	oxidase subunit
GPY20_RS15900	COG1294	oxidase, subunit
GPY20_RS15940	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY20_RS15945	COG2814	Major facilitator Superfamily
GPY20_RS15955	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY20_RS15960	COG1169	isochorismate synthase
GPY20_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS15970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY20_RS15975	COG3433	isochorismatase activity
GPY20_RS15975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY20_RS15975	COG2226	methyltransferase
GPY20_RS15990	COG4592	Periplasmic binding protein
GPY20_RS15995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY20_RS16000	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY20_RS16005	COG1629	transport
GPY20_RS16005	COG4774	siderophore transport
GPY20_RS16015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY20_RS16020	COG1120	ATPase activity
GPY20_RS16030	COG1609	Transcriptional regulator
GPY20_RS16035	COG2723	6-phospho-beta-galactosidase activity
GPY20_RS16040	COG1741	Belongs to the pirin family
GPY20_RS16045	COG0352	thiamine-phosphate diphosphorylase activity
GPY20_RS16055	COG0351	phosphomethylpyrimidine kinase
GPY20_RS16065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY20_RS16070	COG0601	transmembrane transport
GPY20_RS16075	COG0747	negative chemotaxis
GPY20_RS16085	COG1538	Outer membrane efflux protein
GPY20_RS16090	COG1566	PFAM secretion protein HlyD family protein
GPY20_RS16095	COG2814	Major facilitator Superfamily
GPY20_RS16100	COG3708	Transcriptional regulator
GPY20_RS16100	COG2207	Transcriptional regulator
GPY20_RS16110	COG0745	RESPONSE REGULATOR receiver
GPY20_RS16120	COG1263	PTS System
GPY20_RS16120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY20_RS16130	COG1621	beta-fructofuranosidase activity
GPY20_RS16135	COG2200	EAL domain
GPY20_RS16135	COG2202	Pas domain
GPY20_RS16135	COG2199	diguanylate cyclase activity
GPY20_RS16145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY20_RS16160	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS16195	COG2986	histidine ammonia-lyase
GPY20_RS16200	COG1216	Glycosyl transferase, family 2
GPY20_RS16210	COG0318	PFAM AMP-dependent synthetase and ligase
GPY20_RS16220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY20_RS16225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY20_RS16230	COG0318	PFAM AMP-dependent synthetase and ligase
GPY20_RS16230	COG0204	Acyl-transferase
GPY20_RS16260	COG0601	transmembrane transport
GPY20_RS16265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY20_RS16270	COG0444	Belongs to the ABC transporter superfamily
GPY20_RS16285	COG0435	Glutathione S-transferase
GPY20_RS16290	COG3174	membrane
GPY20_RS16295	COG0857	belongs to the CobB CobQ family
GPY20_RS16295	COG0280	phosphate acetyltransferase
GPY20_RS16300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY20_RS16305	COG3092	negative regulation of chromosome organization
GPY20_RS16315	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY20_RS16325	COG3706	GGDEF domain
GPY20_RS16340	COG0653	protein targeting
GPY20_RS16345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY20_RS16350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY20_RS16355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY20_RS16365	COG0243	molybdopterin cofactor binding
GPY20_RS16370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY20_RS16370	COG1648	precorrin-2 dehydrogenase activity
GPY20_RS16385	COG1116	anion transmembrane transporter activity
GPY20_RS16385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY20_RS16390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY20_RS16395	COG1116	anion transmembrane transporter activity
GPY20_RS16400	COG2146	nitrite reductase [NAD(P)H] activity
GPY20_RS16400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY20_RS16410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY20_RS16415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY20_RS16425	COG2226	methyltransferase
GPY20_RS16430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY20_RS16440	COG0501	Belongs to the peptidase M48B family
GPY20_RS16450	COG1028	Short-chain dehydrogenase reductase Sdr
GPY20_RS16465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY20_RS16485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY20_RS16490	COG2915	High frequency lysogenization protein hflD homolog
GPY20_RS16495	COG0482	sulfurtransferase activity
GPY20_RS16500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY20_RS16505	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY20_RS16510	COG1757	Na H antiporter
GPY20_RS16520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY20_RS16525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY20_RS16530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY20_RS16535	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY20_RS16535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY20_RS16540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY20_RS16545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY20_RS16555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY20_RS16555	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY20_RS16560	COG1187	pseudouridine synthase activity
GPY20_RS16570	COG1278	Cold shock
GPY20_RS16575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY20_RS16580	COG0542	response to heat
GPY20_RS16585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY20_RS16590	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY20_RS16595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY20_RS16605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY20_RS16615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY20_RS16620	COG3706	GGDEF domain
GPY20_RS16620	COG0745	RESPONSE REGULATOR receiver
GPY20_RS16625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY20_RS16630	COG0297	glycogen (starch) synthase activity
GPY20_RS16650	COG3070	regulator of competence-specific genes
GPY20_RS16655	COG1609	Transcriptional regulator
GPY20_RS16660	COG3381	protein complex oligomerization
GPY20_RS16665	COG0745	RESPONSE REGULATOR receiver
GPY20_RS16670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY20_RS16675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY20_RS16680	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY20_RS16685	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY20_RS16690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY20_RS16695	COG0189	ligase activity
GPY20_RS16705	COG0189	ligase activity
GPY20_RS16705	COG4067	protein conserved in archaea
GPY20_RS16710	COG0500	methyltransferase
GPY20_RS16715	COG4106	trans-aconitate 2-methyltransferase activity
GPY20_RS16730	COG1435	thymidine kinase activity
GPY20_RS16735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY20_RS16740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY20_RS16760	COG2116	formate transmembrane transporter activity
GPY20_RS16765	COG0390	transport system, permease component
GPY20_RS16770	COG4459	periplasmic nitrate reductase
GPY20_RS16775	COG3005	denitrification pathway
GPY20_RS16780	COG0243	molybdopterin cofactor binding
GPY20_RS16800	COG1227	inorganic diphosphatase activity
GPY20_RS16815	COG4172	Belongs to the ABC transporter superfamily
GPY20_RS16825	COG4171	peptide transport system, permease
GPY20_RS16830	COG4168	peptide transport system, permease
GPY20_RS16840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY20_RS16845	COG1842	Phage shock protein A
GPY20_RS16860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY20_RS16875	COG0519	Catalyzes the synthesis of GMP from XMP
GPY20_RS16905	COG0626	cystathionine gamma-synthase activity
GPY20_RS16915	COG0733	neurotransmitter:sodium symporter activity
GPY20_RS16935	COG0564	pseudouridine synthase activity
GPY20_RS16945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY20_RS16950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY20_RS16955	COG4136	ATPase activity
GPY20_RS16960	COG4135	transport system, permease component
GPY20_RS16965	COG4134	Bacterial extracellular solute-binding protein
GPY20_RS16975	COG3313	Fe-S protein
GPY20_RS16985	COG0842	Transport permease protein
GPY20_RS16990	COG1131	(ABC) transporter
GPY20_RS17000	COG0814	amino acid
GPY20_RS17015	COG3706	GGDEF domain
GPY20_RS17020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY20_RS17030	COG1278	Cold shock
GPY20_RS17040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY20_RS17050	COG3119	arylsulfatase activity
GPY20_RS17055	COG0641	radical SAM
GPY20_RS17060	COG0714	Associated with various cellular activities
GPY20_RS17095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY20_RS17100	COG2205	protein histidine kinase activity
GPY20_RS17105	COG0745	RESPONSE REGULATOR receiver
GPY20_RS17115	COG1061	Type III restriction enzyme res subunit
GPY20_RS17125	COG2814	Major facilitator Superfamily
GPY20_RS17135	COG0702	epimerase
GPY20_RS17140	COG0534	Mate efflux family protein
GPY20_RS17145	COG4181	ATPase activity
GPY20_RS17160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY20_RS17210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY20_RS17220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY20_RS17225	COG3265	gluconokinase activity
GPY20_RS17230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY20_RS17260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY20_RS17280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY20_RS17305	COG2989	Protein conserved in bacteria
GPY20_RS17310	COG3108	Peptidase M15
GPY20_RS17315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY20_RS17330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY20_RS17350	COG2197	response regulator
GPY20_RS17355	COG1846	Transcriptional regulator
GPY20_RS17360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY20_RS17365	COG0840	transmembrane signaling receptor activity
GPY20_RS17370	COG2176	DNA-directed DNA polymerase activity
GPY20_RS17375	COG0517	IMP dehydrogenase activity
GPY20_RS17385	COG1448	Aminotransferase
GPY20_RS17405	COG0840	transmembrane signaling receptor activity
GPY20_RS17410	COG0720	synthase
GPY20_RS17415	COG1538	Outer membrane efflux protein
GPY20_RS17420	COG1136	(ABC) transporter
GPY20_RS17420	COG0577	efflux transmembrane transporter activity
GPY20_RS17425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY20_RS17430	COG1760	l-serine dehydratase
GPY20_RS17435	COG0814	amino acid
GPY20_RS17440	COG0494	nUDIX hydrolase
GPY20_RS17455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY20_RS17470	COG3106	COG3106 Predicted ATPase
GPY20_RS17480	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY20_RS17485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY20_RS17505	COG0471	metal ion transport
GPY20_RS17510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY20_RS17510	COG4191	Histidine kinase
GPY20_RS17520	COG0583	DNA-binding transcription factor activity
GPY20_RS17525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY20_RS17530	COG0778	Nitroreductase
GPY20_RS17535	COG2991	Protein conserved in bacteria
GPY20_RS17545	COG3250	beta-galactosidase activity
GPY20_RS17555	COG1129	ABC transporter
GPY20_RS17595	COG2169	Transcriptional regulator
GPY20_RS17595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY20_RS17605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY20_RS17610	COG0372	Belongs to the citrate synthase family
GPY20_RS17615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPY20_RS17620	COG2828	Protein conserved in bacteria
GPY20_RS17635	COG1566	PFAM secretion protein HlyD family protein
GPY20_RS17640	COG2814	Major facilitator Superfamily
GPY20_RS17655	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY20_RS17660	COG2200	EAL domain
GPY20_RS17670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY20_RS17680	COG0625	glutathione transferase activity
GPY20_RS17700	COG2731	YhcH YjgK YiaL family protein
GPY20_RS17705	COG0584	glycerophosphoryl diester phosphodiesterase
GPY20_RS17710	COG1349	DNA-binding transcription factor activity
GPY20_RS17715	COG3842	ATPase activity
GPY20_RS17720	COG0395	ABC-type sugar transport system, permease component
GPY20_RS17740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY20_RS17745	COG3040	lipid binding
GPY20_RS17755	COG0811	peptide transport
GPY20_RS17760	COG0811	peptide transport
GPY20_RS17765	COG0848	biopolymer transport protein
GPY20_RS17785	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY20_RS17790	COG1793	dna ligase
GPY20_RS17805	COG0307	riboflavin synthase, alpha
GPY20_RS17825	COG0791	NLP P60 protein
GPY20_RS17830	COG0840	transmembrane signaling receptor activity
GPY20_RS17845	COG1940	carbohydrate kinase activity
GPY20_RS17855	COG0303	'Molybdopterin
GPY20_RS17860	COG0746	molybdenum cofactor guanylyltransferase activity
GPY20_RS17865	COG3842	ATPase activity
GPY20_RS17870	COG4662	Binding-protein-dependent transport system inner membrane component
GPY20_RS17880	COG2204	response regulator
GPY20_RS17885	COG3852	Histidine kinase
GPY20_RS17900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY20_RS17920	COG3381	protein complex oligomerization
GPY20_RS17935	COG0437	4 iron, 4 sulfur cluster binding
GPY20_RS17950	COG0004	ammonium transporteR
GPY20_RS17955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY20_RS17960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY20_RS17965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY20_RS17970	COG1177	transmembrane transport
GPY20_RS17975	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY20_RS17980	COG3842	ATPase activity
GPY20_RS18005	COG0589	response to stress
GPY20_RS18010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY20_RS18025	COG2217	Heavy metal translocating P-type atpase
GPY20_RS18035	COG2010	Cytochrome c
GPY20_RS18050	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY20_RS18085	COG3120	sequence-specific DNA binding
GPY20_RS18090	COG1067	ATP-dependent peptidase activity
GPY20_RS18095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY20_RS18120	COG0116	Belongs to the methyltransferase superfamily
GPY20_RS18120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY20_RS18130	COG0167	dihydroorotate dehydrogenase activity
GPY20_RS18145	COG0308	aminopeptidase N
GPY20_RS18170	COG1956	GAF domain-containing protein
GPY20_RS18175	COG1132	(ABC) transporter
GPY20_RS18180	COG2995	paraquat-inducible protein a
GPY20_RS18185	COG3008	intermembrane lipid transfer
GPY20_RS18190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY20_RS18190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY20_RS18195	COG2996	Protein conserved in bacteria
GPY20_RS18210	COG0574	Belongs to the PEP-utilizing enzyme family
GPY20_RS18210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY20_RS18215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY20_RS18225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY20_RS18240	COG1115	amino acid carrier protein
GPY20_RS18265	COG3501	Rhs element vgr protein
GPY20_RS18275	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY20_RS18285	COG1643	Atp-dependent helicase
GPY20_RS18290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY20_RS18300	COG3005	denitrification pathway
GPY20_RS18325	COG3706	GGDEF domain
GPY20_RS18340	COG0443	Heat shock 70 kDa protein
GPY20_RS18345	COG3706	GGDEF domain
GPY20_RS18355	COG3706	GGDEF domain
GPY20_RS18370	COG2999	glutathione oxidoreductase activity
GPY20_RS18390	COG3706	GGDEF domain
GPY20_RS18390	COG0745	RESPONSE REGULATOR receiver
GPY20_RS18400	COG0243	molybdopterin cofactor binding
GPY20_RS18405	COG3005	denitrification pathway
GPY20_RS18415	COG0602	queuosine metabolic process
GPY20_RS18420	COG0561	phosphatase activity
GPY20_RS18430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY20_RS18435	COG4597	amino acid ABC transporter
GPY20_RS18440	COG0765	amino acid transport
GPY20_RS18445	COG1126	abc transporter atp-binding protein
GPY20_RS18450	COG0670	Belongs to the BI1 family
GPY20_RS18455	COG2920	part of a sulfur-relay system
GPY20_RS18460	COG1254	Belongs to the acylphosphatase family
GPY20_RS18470	COG3391	amine dehydrogenase activity
GPY20_RS18490	COG2010	Cytochrome c
GPY20_RS18510	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY20_RS18515	COG5002	protein histidine kinase activity
GPY20_RS18520	COG0745	RESPONSE REGULATOR receiver
GPY20_RS18535	COG0668	transmembrane transport
GPY20_RS18570	COG1278	Cold shock
GPY20_RS18600	COG4974	Belongs to the 'phage' integrase family
GPY20_RS18800	COG4695	Portal protein
GPY20_RS18840	COG4386	tail sheath protein
GPY20_RS18880	COG0745	RESPONSE REGULATOR receiver
GPY20_RS18880	COG3706	GGDEF domain
GPY20_RS18895	COG0784	Response regulator, receiver
GPY20_RS18895	COG0835	chemotaxis
GPY20_RS18905	COG4565	transcriptional regulatory protein
GPY20_RS18910	COG3290	protein histidine kinase activity
GPY20_RS18925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY20_RS18945	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY20_RS18950	COG3063	Type IV pilus biogenesis stability protein PilW
GPY20_RS18965	COG1451	nucleotide metabolic process
GPY20_RS18975	COG0583	DNA-binding transcription factor activity
GPY20_RS19025	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY20_RS19030	COG4139	cobalamin transport
GPY20_RS19035	COG2988	succinylglutamate desuccinylase activity
GPY20_RS19050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY20_RS19055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY20_RS19060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GPY20_RS19065	COG0702	epimerase
GPY20_RS19080	COG2925	Exonuclease
GPY20_RS19090	COG1346	cytolysis
GPY20_RS19095	COG0295	cytidine deaminase activity
GPY20_RS19100	COG3300	MHYT domain
GPY20_RS19100	COG5001	Diguanylate cyclase
GPY20_RS19120	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY20_RS19130	COG0500	methyltransferase
GPY20_RS19140	COG0776	regulation of translation
GPY20_RS19145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY20_RS19145	COG0072	phenylalanine-tRNA ligase activity
GPY20_RS19150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY20_RS19165	COG3706	GGDEF domain
GPY20_RS19165	COG0745	RESPONSE REGULATOR receiver
GPY20_RS19170	COG2133	pyrroloquinoline quinone binding
GPY20_RS19200	COG0322	excinuclease ABC activity
GPY20_RS19205	COG2197	response regulator
GPY20_RS19210	COG0417	DNA replication proofreading
GPY20_RS19215	COG5001	Diguanylate cyclase
GPY20_RS19225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY20_RS19245	COG1228	amidohydrolase
GPY20_RS19250	COG0010	Belongs to the arginase family
GPY20_RS19260	COG2986	histidine ammonia-lyase
GPY20_RS19280	COG0277	FAD linked oxidase domain protein
GPY20_RS19280	COG0247	lactate metabolic process
GPY20_RS19295	COG2885	chlorophyll binding
GPY20_RS19325	COG1643	Atp-dependent helicase
GPY20_RS19330	COG0281	malic enzyme
GPY20_RS19355	COG0583	DNA-binding transcription factor activity
GPY20_RS19370	COG0640	Transcriptional regulator
GPY20_RS19395	COG2949	membrane
GPY20_RS19405	COG1414	Transcriptional regulator
GPY20_RS19410	COG1414	Transcriptional regulator
GPY20_RS19420	COG1454	alcohol dehydrogenase
GPY20_RS19425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY20_RS19445	COG0492	ferredoxin-NADP+ reductase activity
GPY20_RS19450	COG4988	ABC transporter
GPY20_RS19455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY20_RS19460	COG0739	heme binding
GPY20_RS19480	COG1187	pseudouridine synthase activity
GPY20_RS19485	COG0009	L-threonylcarbamoyladenylate synthase
GPY20_RS19490	COG0613	PHP domain protein
GPY20_RS19500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY20_RS19505	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY20_RS19510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY20_RS19515	COG0134	indole-3-glycerol-phosphate synthase activity
GPY20_RS19515	COG0135	phosphoribosylanthranilate isomerase activity
GPY20_RS19520	COG0133	tryptophan synthase activity
GPY20_RS19530	COG1301	dicarboxylic acid transport
GPY20_RS19545	COG1607	acyl-coa hydrolase
GPY20_RS19550	COG2350	Protein conserved in bacteria
GPY20_RS19560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY20_RS19565	COG0583	DNA-binding transcription factor activity
GPY20_RS19580	COG0612	Peptidase, M16
GPY20_RS19600	COG0625	glutathione transferase activity
GPY20_RS19610	COG2771	luxR family
GPY20_RS19610	COG2200	EAL domain
GPY20_RS19615	COG0840	transmembrane signaling receptor activity
GPY20_RS19630	COG1794	racemase activity, acting on amino acids and derivatives
GPY20_RS19635	COG0346	lactoylglutathione lyase activity
GPY20_RS19640	COG5002	protein histidine kinase activity
GPY20_RS19645	COG0745	RESPONSE REGULATOR receiver
GPY20_RS19665	COG0488	(ABC) transporter
GPY20_RS19670	COG1032	radical SAM domain protein
GPY20_RS19675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY20_RS19685	COG3852	Histidine kinase
GPY20_RS19700	COG3070	regulator of competence-specific genes
GPY20_RS19710	COG2431	L-lysine efflux transmembrane transporter activity
GPY20_RS19720	COG0076	glutamate decarboxylase activity
GPY20_RS19725	COG1737	Transcriptional regulator
GPY20_RS19730	COG1454	alcohol dehydrogenase
GPY20_RS19730	COG1012	belongs to the aldehyde dehydrogenase family
GPY20_RS19735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY20_RS19745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY20_RS19750	COG1960	acyl-CoA dehydrogenase activity
GPY20_RS19770	COG1012	belongs to the aldehyde dehydrogenase family
GPY20_RS19825	COG5002	protein histidine kinase activity
GPY20_RS19825	COG0784	Response regulator, receiver
GPY20_RS19835	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY20_RS19840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY20_RS19845	COG2885	chlorophyll binding
GPY20_RS19865	COG0811	peptide transport
GPY20_RS19870	COG0824	Thioesterase
GPY20_RS19880	COG4890	Cyd operon protein YbgT
GPY20_RS19885	COG1294	oxidase, subunit
GPY20_RS19890	COG1271	oxidase subunit
GPY20_RS19895	COG2255	four-way junction helicase activity
GPY20_RS19900	COG0632	four-way junction helicase activity
GPY20_RS19905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY20_RS19910	COG0215	cysteine-tRNA ligase activity
GPY20_RS19915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY20_RS19920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY20_RS19925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY20_RS19930	COG3012	SEC-C Motif Domain Protein
GPY20_RS19940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY20_RS19945	COG1199	ATP-dependent helicase activity
GPY20_RS19950	COG3923	Primosomal replication protein n
GPY20_RS19960	COG0840	transmembrane signaling receptor activity
GPY20_RS19965	COG0708	Exodeoxyribonuclease III
GPY20_RS19975	COG4160	amino acid transport
GPY20_RS19980	COG4215	(ABC) transporter
GPY20_RS20000	COG1882	Formate acetyltransferase
GPY20_RS20015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY20_RS20035	COG2766	serine protein kinase
GPY20_RS20040	COG2718	Belongs to the UPF0229 family
GPY20_RS20045	COG2719	SpoVR family
GPY20_RS20050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY20_RS20065	COG1132	(ABC) transporter
GPY20_RS20070	COG0658	competence protein
GPY20_RS20070	COG2333	competence protein COMEC
GPY20_RS20080	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY20_RS20085	COG1136	(ABC) transporter
GPY20_RS20090	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY20_RS20100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY20_RS20115	COG1252	NADH dehydrogenase
GPY20_RS20145	COG0537	adenosine 5'-monophosphoramidase activity
GPY20_RS20160	COG2186	Transcriptional regulator
GPY20_RS20165	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY20_RS20170	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY20_RS20175	COG1674	ftsk spoiiie
GPY20_RS20180	COG1522	sequence-specific DNA binding
GPY20_RS20185	COG0686	Belongs to the AlaDH PNT family
GPY20_RS20195	COG0583	DNA-binding transcription factor activity
GPY20_RS20215	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY20_RS20220	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY20_RS20230	COG0539	negative regulation of cytoplasmic translation
GPY20_RS20235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY20_RS20240	COG1555	photosystem II stabilization
GPY20_RS20245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY20_RS20250	COG0776	regulation of translation
GPY20_RS20255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY20_RS20260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY20_RS20270	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY20_RS20275	COG4191	Histidine kinase
GPY20_RS20280	COG2204	response regulator
GPY20_RS20285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY20_RS20290	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY20_RS20295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY20_RS20315	COG0745	RESPONSE REGULATOR receiver
GPY20_RS20320	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY20_RS20325	COG1760	l-serine dehydratase
GPY20_RS20335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY20_RS20335	COG3153	acetyltransferase
GPY20_RS20345	COG5001	Diguanylate cyclase
GPY20_RS20345	COG1716	ATPase activity
GPY20_RS20355	COG4589	Belongs to the CDS family
GPY20_RS20390	COG2197	response regulator
GPY20_RS20395	COG3851	Histidine kinase
GPY20_RS20400	COG2271	Major facilitator Superfamily
GPY20_RS20405	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY20_RS20415	COG3842	ATPase activity
GPY20_RS20440	COG0210	DNA helicase
GPY20_RS20490	COG3550	peptidyl-serine autophosphorylation
GPY20_RS20520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY20_RS20525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY20_RS20535	COG2951	lytic endotransglycosylase activity
GPY20_RS20540	COG3100	YcgL domain-containing protein
GPY20_RS20550	COG2894	cell division
GPY20_RS20555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY20_RS20565	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY20_RS20570	COG0318	PFAM AMP-dependent synthetase and ligase
GPY20_RS20590	COG1214	PFAM Peptidase M22, glycoprotease
GPY20_RS20595	COG1199	ATP-dependent helicase activity
GPY20_RS20605	COG0788	formyltetrahydrofolate deformylase activity
GPY20_RS20610	COG1902	pentaerythritol trinitrate reductase activity
GPY20_RS20610	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY20_RS20615	COG0616	signal peptide processing
GPY20_RS20620	COG0252	asparaginase activity
GPY20_RS20625	COG3139	Protein of unknown function (DUF1315)
GPY20_RS20635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY20_RS20640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY20_RS20650	COG2226	methyltransferase
GPY20_RS20810	COG4695	Portal protein
GPY20_RS20905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY20_RS20920	COG4974	Belongs to the 'phage' integrase family
GPY20_RS20935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY20_RS20940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY20_RS20945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY20_RS20955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY20_RS20960	COG2832	Protein of unknown function (DUF454)
GPY20_RS20970	COG0745	RESPONSE REGULATOR receiver
GPY20_RS20975	COG0583	DNA-binding transcription factor activity
GPY20_RS20980	COG0778	Nitroreductase
GPY20_RS20985	COG1024	Enoyl-CoA hydratase
GPY20_RS20985	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY20_RS20990	COG0183	Belongs to the thiolase family
GPY20_RS21010	COG2067	long-chain fatty acid transport protein
GPY20_RS21015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY20_RS21030	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY20_RS21035	COG2982	Protein involved in outer membrane biogenesis
GPY20_RS21040	COG0572	uridine kinase
GPY20_RS21045	COG0489	protein tyrosine kinase activity
GPY20_RS21050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY20_RS21050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY20_RS21060	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY20_RS21070	COG0516	GMP reductase activity
GPY20_RS21070	COG0517	IMP dehydrogenase activity
GPY20_RS21075	COG3706	GGDEF domain
GPY20_RS21080	COG0314	molybdopterin synthase activity
GPY20_RS21085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY20_RS21090	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY20_RS21095	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY20_RS21100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY20_RS21105	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY20_RS21110	COG2198	Histidine kinase
GPY20_RS21115	COG2204	response regulator
GPY20_RS21135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY20_RS21140	COG4657	Part of a membrane complex involved in electron transport
GPY20_RS21145	COG2878	Part of a membrane complex involved in electron transport
GPY20_RS21150	COG4656	Part of a membrane complex involved in electron transport
GPY20_RS21155	COG4658	electron transport chain
GPY20_RS21165	COG4660	Part of a membrane complex involved in electron transport
GPY20_RS21170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY20_RS21175	COG0346	lactoylglutathione lyase activity
GPY20_RS21190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY20_RS21195	COG2056	Na+-H+ antiporter family
GPY20_RS21200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY20_RS21205	COG1286	toxin biosynthetic process
GPY20_RS21210	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY20_RS21215	COG0285	dihydrofolate synthase activity
GPY20_RS21225	COG0101	tRNA pseudouridine synthase activity
GPY20_RS21235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY20_RS21240	COG1263	PTS System
GPY20_RS21240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY20_RS21240	COG2190	(PTS) system
GPY20_RS21245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY20_RS21250	COG1846	Transcriptional regulator
GPY20_RS21250	COG1940	carbohydrate kinase activity
GPY20_RS21255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY20_RS21255	COG4651	solute:proton antiporter activity
GPY20_RS21260	COG0367	asparagine synthase
GPY20_RS21270	COG3104	oligopeptide transport
GPY20_RS21275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY20_RS21285	COG0326	Molecular chaperone. Has ATPase activity
GPY20_RS21290	COG3710	Transcriptional regulator
GPY20_RS21305	COG0622	Phosphoesterase
GPY20_RS21330	COG1090	epimerase
GPY20_RS21335	COG0300	oxidoreductase activity
GPY20_RS21345	COG3118	belongs to the thioredoxin family
GPY20_RS21350	COG0330	HflC and HflK could
GPY20_RS21360	COG0789	Transcriptional regulator
GPY20_RS21375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY20_RS21380	COG3115	cell septum assembly
GPY20_RS21385	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY20_RS21390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY20_RS21400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY20_RS21410	COG2190	(PTS) system
GPY20_RS21415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY20_RS21420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY20_RS21425	COG1702	phosphate starvation-inducible protein PhoH
GPY20_RS21430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY20_RS21435	COG4535	Mg2 and Co2 transporter CorC
GPY20_RS21440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY20_RS21445	COG2888	peptidyl-tyrosine sulfation
GPY20_RS21455	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY20_RS21460	COG1466	dna polymerase III delta subunit
GPY20_RS21465	COG0799	negative regulation of ribosome biogenesis
GPY20_RS21470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY20_RS21475	COG0768	penicillin binding
GPY20_RS21480	COG0772	Belongs to the SEDS family
GPY20_RS21485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY20_RS21490	COG1686	Belongs to the peptidase S11 family
GPY20_RS21495	COG2921	Belongs to the UPF0250 family
GPY20_RS21500	COG0321	lipoyl(octanoyl) transferase activity
GPY20_RS21505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY20_RS21515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY20_RS21525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY20_RS21530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY20_RS21555	COG0366	Alpha amylase catalytic
GPY20_RS21560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY20_RS21560	COG1263	PTS System
GPY20_RS21575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY20_RS21580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY20_RS21585	COG2011	ABC-type metal ion transport system permease component
GPY20_RS21590	COG1464	Belongs to the NlpA lipoprotein family
GPY20_RS21595	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY20_RS21605	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY20_RS21605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY20_RS21615	COG3706	GGDEF domain
GPY20_RS21615	COG0745	RESPONSE REGULATOR receiver
GPY20_RS21620	COG1611	Belongs to the LOG family
GPY20_RS21625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY20_RS21635	COG2363	Small membrane protein
GPY20_RS21645	COG0583	DNA-binding transcription factor activity
GPY20_RS21650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY20_RS21650	COG0301	tRNA thio-modification
GPY20_RS21660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY20_RS21670	COG0142	geranyltranstransferase activity
GPY20_RS21675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY20_RS21680	COG0564	pseudouridine synthase activity
GPY20_RS21685	COG3098	single-species biofilm formation
GPY20_RS21710	COG1671	Belongs to the UPF0178 family
GPY20_RS21715	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY20_RS21720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY20_RS21725	COG0254	rRNA binding
GPY20_RS21730	COG1720	tRNA m6t6A37 methyltransferase activity
GPY20_RS21735	COG0442	prolyl-tRNA aminoacylation
GPY20_RS21760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY20_RS21765	COG0590	tRNA wobble adenosine to inosine editing
GPY20_RS21770	COG0583	DNA-binding transcription factor activity
GPY20_RS21775	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY20_RS21780	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GPY20_RS21785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY20_RS21810	COG4969	Belongs to the N-Me-Phe pilin family
GPY20_RS21820	COG0443	Heat shock 70 kDa protein
GPY20_RS21830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY20_RS21835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY20_RS21840	COG0497	DNA recombination
GPY20_RS21845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY20_RS21850	COG2914	Belongs to the UPF0125 (RnfH) family
GPY20_RS21855	COG2867	negative regulation of translational initiation
GPY20_RS21860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY20_RS21885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY20_RS21895	COG0583	DNA-binding transcription factor activity
GPY20_RS21900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity