locus-tag	class	description
GO174_RS00005	COG3164	Protein of unknown function
GO174_RS00010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO174_RS00015	COG0312	modulator of DNA gyrase
GO174_RS00035	COG0589	response to stress
GO174_RS00055	COG0039	L-malate dehydrogenase activity
GO174_RS00060	COG0531	amino acid
GO174_RS00065	COG0142	geranyltranstransferase activity
GO174_RS00070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO174_RS00075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO174_RS00080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO174_RS00085	COG2966	Psort location CytoplasmicMembrane, score
GO174_RS00090	COG3610	response to peptide
GO174_RS00105	COG2967	ApaG domain
GO174_RS00120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO174_RS00125	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GO174_RS00130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO174_RS00185	COG0741	lytic transglycosylase activity
GO174_RS00190	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GO174_RS00195	COG1194	a g-specific adenine glycosylase
GO174_RS00200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO174_RS00205	COG2066	Belongs to the glutaminase family
GO174_RS00210	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO174_RS00215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO174_RS00230	COG1872	DUF167
GO174_RS00235	COG0762	integral membrane protein
GO174_RS00240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO174_RS00245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO174_RS00260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GO174_RS00265	COG1678	Uncharacterized ACR, COG1678
GO174_RS00270	COG0189	ligase activity
GO174_RS00275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO174_RS00280	COG2356	endonuclease I
GO174_RS00300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO174_RS00305	COG0583	DNA-binding transcription factor activity
GO174_RS00310	COG4771	TonB-dependent receptor
GO174_RS00315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO174_RS00320	COG0126	phosphoglycerate kinase activity
GO174_RS00325	COG0191	fructose-bisphosphate aldolase activity
GO174_RS00330	COG0668	transmembrane transport
GO174_RS00355	COG3706	GGDEF domain
GO174_RS00360	COG0469	pyruvate kinase activity
GO174_RS00365	COG1349	DNA-binding transcription factor activity
GO174_RS00370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO174_RS00375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO174_RS00385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO174_RS00400	COG1596	polysaccharide export
GO174_RS00410	COG0489	protein tyrosine kinase activity
GO174_RS00410	COG3206	protein involved in exopolysaccharide biosynthesis
GO174_RS00455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO174_RS00465	COG1610	YqeY-like protein
GO174_RS00470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GO174_RS00475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO174_RS00480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GO174_RS00485	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO174_RS00490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO174_RS00495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO174_RS00505	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO174_RS00510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO174_RS00520	COG0585	pseudouridine synthase activity
GO174_RS00525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GO174_RS00535	COG4942	peptidase
GO174_RS00535	COG1388	LysM domain
GO174_RS00540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO174_RS00545	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GO174_RS00550	COG1546	Belongs to the CinA family
GO174_RS00555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GO174_RS00565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO174_RS00570	COG0527	aspartate kinase activity
GO174_RS00620	COG3630	sodium ion export across plasma membrane
GO174_RS00625	COG0511	ligase activity, forming carbon-carbon bonds
GO174_RS00625	COG5016	pyruvate
GO174_RS00630	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GO174_RS00635	COG1063	alcohol dehydrogenase
GO174_RS00640	COG1238	metal cluster binding
GO174_RS00645	COG0612	Peptidase, M16
GO174_RS00660	COG1854	S-ribosylhomocysteine lyase activity
GO174_RS00665	COG4536	flavin adenine dinucleotide binding
GO174_RS00670	COG4137	Cytochrome C assembly protein
GO174_RS00675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO174_RS00685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO174_RS00695	COG0335	large ribosomal subunit rRNA binding
GO174_RS00700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO174_RS00705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO174_RS00710	COG3105	Protein conserved in bacteria
GO174_RS00715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GO174_RS00725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO174_RS00730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO174_RS00735	COG0723	plastoquinol--plastocyanin reductase activity
GO174_RS00740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO174_RS00745	COG2857	Cytochrome c1
GO174_RS00750	COG0625	glutathione transferase activity
GO174_RS00755	COG2969	positive regulation of protein catabolic process
GO174_RS00760	COG2823	Periplasmic or secreted lipoprotein
GO174_RS00765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO174_RS00770	COG0792	nuclease activity
GO174_RS00775	COG3107	peptidoglycan biosynthetic process
GO174_RS00780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO174_RS00790	COG0275	rRNA processing
GO174_RS00795	COG3116	cell division
GO174_RS00800	COG0768	penicillin binding
GO174_RS00805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GO174_RS00810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO174_RS00815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO174_RS00820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO174_RS00825	COG0772	Belongs to the SEDS family
GO174_RS00830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO174_RS00835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO174_RS00840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO174_RS00845	COG0849	cell division
GO174_RS00850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO174_RS00855	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GO174_RS00865	COG0653	protein targeting
GO174_RS00870	COG0494	nUDIX hydrolase
GO174_RS00880	COG0505	Belongs to the CarA family
GO174_RS00885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO174_RS00890	COG0730	response to heat
GO174_RS00895	COG0583	DNA-binding transcription factor activity
GO174_RS00915	COG2860	membrane
GO174_RS00920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO174_RS00940	COG0493	'glutamate synthase
GO174_RS00945	COG0067	glutamate synthase
GO174_RS00945	COG0069	glutamate synthase activity
GO174_RS00945	COG0070	glutamate synthase
GO174_RS00955	COG0067	glutamate synthase
GO174_RS00955	COG0070	glutamate synthase
GO174_RS00955	COG0069	glutamate synthase activity
GO174_RS00960	COG1242	4 iron, 4 sulfur cluster binding
GO174_RS00965	COG2203	Gaf domain
GO174_RS00965	COG4251	negative regulation of phosphorylation
GO174_RS00965	COG3706	GGDEF domain
GO174_RS00965	COG5001	Diguanylate cyclase
GO174_RS00970	COG0784	Response regulator, receiver
GO174_RS00970	COG2198	Histidine kinase
GO174_RS00970	COG5002	protein histidine kinase activity
GO174_RS00980	COG0745	RESPONSE REGULATOR receiver
GO174_RS00995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO174_RS01010	COG0083	homoserine kinase activity
GO174_RS01015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GO174_RS01035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GO174_RS01050	COG1115	amino acid carrier protein
GO174_RS01055	COG3022	response to hydroperoxide
GO174_RS01060	COG0084	hydrolase, TatD family'
GO174_RS01085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO174_RS01090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO174_RS01095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO174_RS01100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO174_RS01105	COG0813	purine-nucleoside phosphorylase activity
GO174_RS01115	COG0560	Phosphoserine phosphatase
GO174_RS01125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GO174_RS01130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO174_RS01135	COG0583	DNA-binding transcription factor activity
GO174_RS01145	COG0583	DNA-binding transcription factor activity
GO174_RS01155	COG1022	Amp-dependent synthetase and ligase
GO174_RS01185	COG4964	Belongs to the GSP D family
GO174_RS01235	COG3437	response regulator, receiver
GO174_RS01235	COG0784	Response regulator, receiver
GO174_RS01240	COG2059	Chromate
GO174_RS01250	COG2017	converts alpha-aldose to the beta-anomer
GO174_RS01255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO174_RS01270	COG0189	ligase activity
GO174_RS01270	COG0569	domain protein
GO174_RS01285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO174_RS01290	COG2171	N-acyltransferase activity
GO174_RS01295	COG3141	response to X-ray
GO174_RS01300	COG0583	DNA-binding transcription factor activity
GO174_RS01310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GO174_RS01315	COG1074	ATP-dependent DNA helicase activity
GO174_RS01320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO174_RS01330	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO174_RS01330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO174_RS01340	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GO174_RS01345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO174_RS01350	COG2166	iron-sulfur cluster assembly
GO174_RS01360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO174_RS01365	COG0693	protein deglycase activity
GO174_RS01370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO174_RS01375	COG3248	Nucleoside-binding outer membrane protein
GO174_RS01385	COG1595	DNA-templated transcription, initiation
GO174_RS01395	COG0477	Major facilitator Superfamily
GO174_RS01400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO174_RS01410	COG2974	May be involved in recombination
GO174_RS01415	COG0745	RESPONSE REGULATOR receiver
GO174_RS01420	COG5002	protein histidine kinase activity
GO174_RS01430	COG0248	Ppx GppA phosphatase
GO174_RS01435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GO174_RS01440	COG0573	inorganic phosphate transmembrane transporter activity
GO174_RS01445	COG0581	inorganic phosphate transmembrane transporter activity
GO174_RS01450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO174_RS01455	COG0704	Plays a role in the regulation of phosphate uptake
GO174_RS01470	COG0450	alkyl hydroperoxide reductase
GO174_RS01475	COG0583	DNA-binding transcription factor activity
GO174_RS01480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GO174_RS01490	COG0517	IMP dehydrogenase activity
GO174_RS01495	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GO174_RS01500	COG0343	queuine tRNA-ribosyltransferase activity
GO174_RS01505	COG1862	Preprotein translocase
GO174_RS01510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO174_RS01515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO174_RS01520	COG1335	isochorismatase
GO174_RS01525	COG0483	inositol monophosphate 1-phosphatase activity
GO174_RS01530	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GO174_RS01535	COG1959	2 iron, 2 sulfur cluster binding
GO174_RS01540	COG1104	cysteine desulfurase activity
GO174_RS01545	COG0822	iron-sulfur transferase activity
GO174_RS01560	COG0443	Heat shock 70 kDa protein
GO174_RS01565	COG0633	Ferredoxin
GO174_RS01570	COG2975	iron-sulfur cluster assembly
GO174_RS01575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO174_RS01590	COG1426	Protein conserved in bacteria
GO174_RS01595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GO174_RS01600	COG0124	histidyl-tRNA synthetase
GO174_RS01605	COG2976	Protein conserved in bacteria
GO174_RS01610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO174_RS01615	COG1160	GTP binding
GO174_RS01630	COG1570	exodeoxyribonuclease VII activity
GO174_RS01635	COG0517	IMP dehydrogenase activity
GO174_RS01635	COG0516	GMP reductase activity
GO174_RS01640	COG0519	Catalyzes the synthesis of GMP from XMP
GO174_RS01640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO174_RS01650	COG1584	GPR1 FUN34 yaaH family protein
GO174_RS01665	COG1473	amidohydrolase
GO174_RS01675	COG1115	amino acid carrier protein
GO174_RS01680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO174_RS01685	COG0583	DNA-binding transcription factor activity
GO174_RS01695	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GO174_RS01695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO174_RS01730	COG0328	RNA-DNA hybrid ribonuclease activity
GO174_RS01745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO174_RS01750	COG2867	negative regulation of translational initiation
GO174_RS01755	COG2914	Belongs to the UPF0125 (RnfH) family
GO174_RS01760	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO174_RS01765	COG0497	DNA recombination
GO174_RS01770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO174_RS01775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO174_RS01785	COG0443	Heat shock 70 kDa protein
GO174_RS01795	COG4969	Belongs to the N-Me-Phe pilin family
GO174_RS01820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GO174_RS01825	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GO174_RS01830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GO174_RS01835	COG0583	DNA-binding transcription factor activity
GO174_RS01840	COG0590	tRNA wobble adenosine to inosine editing
GO174_RS01845	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO174_RS01870	COG0442	prolyl-tRNA aminoacylation
GO174_RS01875	COG1720	tRNA m6t6A37 methyltransferase activity
GO174_RS01880	COG0254	rRNA binding
GO174_RS01885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO174_RS01890	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GO174_RS01895	COG1671	Belongs to the UPF0178 family
GO174_RS01920	COG3098	single-species biofilm formation
GO174_RS01925	COG0564	pseudouridine synthase activity
GO174_RS01930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO174_RS01935	COG0142	geranyltranstransferase activity
GO174_RS01945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO174_RS01955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO174_RS01955	COG0301	tRNA thio-modification
GO174_RS01960	COG0583	DNA-binding transcription factor activity
GO174_RS01970	COG2363	Small membrane protein
GO174_RS01980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO174_RS01985	COG1611	Belongs to the LOG family
GO174_RS01990	COG3706	GGDEF domain
GO174_RS01990	COG0745	RESPONSE REGULATOR receiver
GO174_RS02000	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO174_RS02000	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO174_RS02010	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GO174_RS02015	COG1464	Belongs to the NlpA lipoprotein family
GO174_RS02020	COG2011	ABC-type metal ion transport system permease component
GO174_RS02025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO174_RS02030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO174_RS02045	COG1263	PTS System
GO174_RS02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO174_RS02050	COG0366	Alpha amylase catalytic
GO174_RS02075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO174_RS02080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO174_RS02090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO174_RS02100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO174_RS02105	COG0321	lipoyl(octanoyl) transferase activity
GO174_RS02110	COG2921	Belongs to the UPF0250 family
GO174_RS02115	COG1686	Belongs to the peptidase S11 family
GO174_RS02120	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO174_RS02125	COG0772	Belongs to the SEDS family
GO174_RS02130	COG0768	penicillin binding
GO174_RS02135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO174_RS02140	COG0799	negative regulation of ribosome biogenesis
GO174_RS02145	COG1466	dna polymerase III delta subunit
GO174_RS02150	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GO174_RS02160	COG2888	peptidyl-tyrosine sulfation
GO174_RS02165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GO174_RS02170	COG4535	Mg2 and Co2 transporter CorC
GO174_RS02175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO174_RS02180	COG1702	phosphate starvation-inducible protein PhoH
GO174_RS02185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO174_RS02190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO174_RS02195	COG2190	(PTS) system
GO174_RS02205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO174_RS02215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO174_RS02220	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GO174_RS02225	COG3115	cell septum assembly
GO174_RS02230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO174_RS02245	COG0789	Transcriptional regulator
GO174_RS02255	COG0330	HflC and HflK could
GO174_RS02260	COG3118	belongs to the thioredoxin family
GO174_RS02270	COG0300	oxidoreductase activity
GO174_RS02275	COG1090	epimerase
GO174_RS02300	COG0622	Phosphoesterase
GO174_RS02315	COG3710	Transcriptional regulator
GO174_RS02320	COG0326	Molecular chaperone. Has ATPase activity
GO174_RS02330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GO174_RS02335	COG3104	oligopeptide transport
GO174_RS02345	COG0367	asparagine synthase
GO174_RS02350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO174_RS02350	COG4651	solute:proton antiporter activity
GO174_RS02355	COG1846	Transcriptional regulator
GO174_RS02355	COG1940	carbohydrate kinase activity
GO174_RS02360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO174_RS02365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO174_RS02365	COG2190	(PTS) system
GO174_RS02365	COG1263	PTS System
GO174_RS02370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO174_RS02380	COG0101	tRNA pseudouridine synthase activity
GO174_RS02390	COG0285	dihydrofolate synthase activity
GO174_RS02395	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GO174_RS02400	COG1286	toxin biosynthetic process
GO174_RS02405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO174_RS02410	COG2056	Na+-H+ antiporter family
GO174_RS02415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO174_RS02430	COG0346	lactoylglutathione lyase activity
GO174_RS02435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO174_RS02440	COG4660	Part of a membrane complex involved in electron transport
GO174_RS02450	COG4658	electron transport chain
GO174_RS02455	COG4656	Part of a membrane complex involved in electron transport
GO174_RS02460	COG2878	Part of a membrane complex involved in electron transport
GO174_RS02465	COG4657	Part of a membrane complex involved in electron transport
GO174_RS02480	COG2204	response regulator
GO174_RS02485	COG2198	Histidine kinase
GO174_RS02490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GO174_RS02495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO174_RS02500	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO174_RS02505	COG0315	cyclic pyranopterin monophosphate synthase activity
GO174_RS02510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GO174_RS02515	COG0314	molybdopterin synthase activity
GO174_RS02520	COG3706	GGDEF domain
GO174_RS02525	COG0516	GMP reductase activity
GO174_RS02525	COG0517	IMP dehydrogenase activity
GO174_RS02535	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GO174_RS02545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO174_RS02545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO174_RS02550	COG0489	protein tyrosine kinase activity
GO174_RS02555	COG0572	uridine kinase
GO174_RS02560	COG2982	Protein involved in outer membrane biogenesis
GO174_RS02565	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GO174_RS02580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO174_RS02585	COG2067	long-chain fatty acid transport protein
GO174_RS02605	COG0183	Belongs to the thiolase family
GO174_RS02610	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO174_RS02610	COG1024	Enoyl-CoA hydratase
GO174_RS02615	COG0778	Nitroreductase
GO174_RS02620	COG0583	DNA-binding transcription factor activity
GO174_RS02625	COG0745	RESPONSE REGULATOR receiver
GO174_RS02635	COG2832	Protein of unknown function (DUF454)
GO174_RS02640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO174_RS02650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO174_RS02655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO174_RS02660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO174_RS02695	COG2226	methyltransferase
GO174_RS02705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO174_RS02710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO174_RS02720	COG3139	Protein of unknown function (DUF1315)
GO174_RS02725	COG0252	asparaginase activity
GO174_RS02730	COG0616	signal peptide processing
GO174_RS02735	COG1902	pentaerythritol trinitrate reductase activity
GO174_RS02735	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO174_RS02740	COG0788	formyltetrahydrofolate deformylase activity
GO174_RS02750	COG1199	ATP-dependent helicase activity
GO174_RS02755	COG1214	PFAM Peptidase M22, glycoprotease
GO174_RS02775	COG0318	PFAM AMP-dependent synthetase and ligase
GO174_RS02780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GO174_RS02790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GO174_RS02795	COG2894	cell division
GO174_RS02805	COG3100	YcgL domain-containing protein
GO174_RS02810	COG2951	lytic endotransglycosylase activity
GO174_RS02820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO174_RS02825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO174_RS02835	COG3842	ATPase activity
GO174_RS02845	COG1840	ABC-type Fe3 transport system, periplasmic component
GO174_RS02850	COG2271	Major facilitator Superfamily
GO174_RS02855	COG3851	Histidine kinase
GO174_RS02860	COG2197	response regulator
GO174_RS02895	COG4589	Belongs to the CDS family
GO174_RS02905	COG1716	ATPase activity
GO174_RS02905	COG5001	Diguanylate cyclase
GO174_RS02915	COG3153	acetyltransferase
GO174_RS02915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO174_RS02925	COG1760	l-serine dehydratase
GO174_RS02930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GO174_RS02935	COG0745	RESPONSE REGULATOR receiver
GO174_RS02950	COG1404	Belongs to the peptidase S8 family
GO174_RS02955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO174_RS02960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO174_RS02965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO174_RS02970	COG2204	response regulator
GO174_RS02975	COG4191	Histidine kinase
GO174_RS02980	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO174_RS02990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO174_RS02995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO174_RS03000	COG0776	regulation of translation
GO174_RS03005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO174_RS03010	COG1555	photosystem II stabilization
GO174_RS03015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO174_RS03020	COG0539	negative regulation of cytoplasmic translation
GO174_RS03030	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GO174_RS03035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GO174_RS03055	COG0583	DNA-binding transcription factor activity
GO174_RS03065	COG0686	Belongs to the AlaDH PNT family
GO174_RS03070	COG1522	sequence-specific DNA binding
GO174_RS03075	COG1674	ftsk spoiiie
GO174_RS03080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO174_RS03085	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO174_RS03090	COG2186	Transcriptional regulator
GO174_RS03105	COG0537	adenosine 5'-monophosphoramidase activity
GO174_RS03135	COG1252	NADH dehydrogenase
GO174_RS03150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GO174_RS03160	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO174_RS03165	COG1136	(ABC) transporter
GO174_RS03170	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO174_RS03180	COG0658	competence protein
GO174_RS03180	COG2333	competence protein COMEC
GO174_RS03185	COG1132	(ABC) transporter
GO174_RS03200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GO174_RS03205	COG2719	SpoVR family
GO174_RS03210	COG2718	Belongs to the UPF0229 family
GO174_RS03215	COG2766	serine protein kinase
GO174_RS03235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO174_RS03250	COG1882	Formate acetyltransferase
GO174_RS03270	COG4215	(ABC) transporter
GO174_RS03275	COG4160	amino acid transport
GO174_RS03280	COG0708	Exodeoxyribonuclease III
GO174_RS03285	COG0840	transmembrane signaling receptor activity
GO174_RS03295	COG3923	Primosomal replication protein n
GO174_RS03300	COG1199	ATP-dependent helicase activity
GO174_RS03305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GO174_RS03310	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GO174_RS03315	COG3012	SEC-C Motif Domain Protein
GO174_RS03320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO174_RS03325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO174_RS03330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO174_RS03335	COG0215	cysteine-tRNA ligase activity
GO174_RS03340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GO174_RS03345	COG0632	four-way junction helicase activity
GO174_RS03350	COG2255	four-way junction helicase activity
GO174_RS03355	COG1271	oxidase subunit
GO174_RS03360	COG1294	oxidase, subunit
GO174_RS03365	COG4890	Cyd operon protein YbgT
GO174_RS03375	COG0824	Thioesterase
GO174_RS03380	COG0811	peptide transport
GO174_RS03400	COG2885	chlorophyll binding
GO174_RS03405	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GO174_RS03410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GO174_RS03420	COG0784	Response regulator, receiver
GO174_RS03420	COG5002	protein histidine kinase activity
GO174_RS03435	COG1012	belongs to the aldehyde dehydrogenase family
GO174_RS03455	COG1960	acyl-CoA dehydrogenase activity
GO174_RS03460	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO174_RS03470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO174_RS03475	COG1979	alcohol dehydrogenase
GO174_RS03480	COG1737	Transcriptional regulator
GO174_RS03485	COG0076	glutamate decarboxylase activity
GO174_RS03495	COG2431	L-lysine efflux transmembrane transporter activity
GO174_RS03505	COG3070	regulator of competence-specific genes
GO174_RS03520	COG3852	Histidine kinase
GO174_RS03530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GO174_RS03535	COG1032	radical SAM domain protein
GO174_RS03540	COG0488	(ABC) transporter
GO174_RS03560	COG0745	RESPONSE REGULATOR receiver
GO174_RS03565	COG5002	protein histidine kinase activity
GO174_RS03570	COG0346	lactoylglutathione lyase activity
GO174_RS03575	COG1794	racemase activity, acting on amino acids and derivatives
GO174_RS03590	COG0840	transmembrane signaling receptor activity
GO174_RS03595	COG2200	EAL domain
GO174_RS03595	COG2771	luxR family
GO174_RS03605	COG0625	glutathione transferase activity
GO174_RS03625	COG0612	Peptidase, M16
GO174_RS03640	COG0583	DNA-binding transcription factor activity
GO174_RS03645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO174_RS03655	COG2350	Protein conserved in bacteria
GO174_RS03660	COG1607	acyl-coa hydrolase
GO174_RS03675	COG1301	dicarboxylic acid transport
GO174_RS03685	COG0133	tryptophan synthase activity
GO174_RS03690	COG0134	indole-3-glycerol-phosphate synthase activity
GO174_RS03690	COG0135	phosphoribosylanthranilate isomerase activity
GO174_RS03695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO174_RS03700	COG0512	Glutamine amidotransferase of anthranilate synthase
GO174_RS03705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO174_RS03715	COG0613	PHP domain protein
GO174_RS03720	COG0009	L-threonylcarbamoyladenylate synthase
GO174_RS03725	COG1187	pseudouridine synthase activity
GO174_RS03750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GO174_RS03755	COG4988	ABC transporter
GO174_RS03760	COG0492	ferredoxin-NADP+ reductase activity
GO174_RS03780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO174_RS03785	COG1454	alcohol dehydrogenase
GO174_RS03795	COG1414	Transcriptional regulator
GO174_RS03800	COG1414	Transcriptional regulator
GO174_RS03810	COG2949	membrane
GO174_RS03835	COG0640	Transcriptional regulator
GO174_RS03850	COG0583	DNA-binding transcription factor activity
GO174_RS03870	COG0281	malic enzyme
GO174_RS03875	COG1643	Atp-dependent helicase
GO174_RS03885	COG1757	Na H antiporter
GO174_RS03890	COG0174	glutamine synthetase
GO174_RS03895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GO174_RS03900	COG1396	sequence-specific DNA binding
GO174_RS03900	COG1917	Cupin 2, conserved barrel domain protein
GO174_RS03905	COG1012	belongs to the aldehyde dehydrogenase family
GO174_RS03910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO174_RS03920	COG2957	Belongs to the agmatine deiminase family
GO174_RS03955	COG2885	chlorophyll binding
GO174_RS03970	COG0247	lactate metabolic process
GO174_RS03970	COG0277	FAD linked oxidase domain protein
GO174_RS03990	COG2986	histidine ammonia-lyase
GO174_RS04000	COG0010	Belongs to the arginase family
GO174_RS04005	COG1228	amidohydrolase
GO174_RS04025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO174_RS04035	COG5001	Diguanylate cyclase
GO174_RS04040	COG0417	DNA replication proofreading
GO174_RS04045	COG2197	response regulator
GO174_RS04050	COG0322	excinuclease ABC activity
GO174_RS04080	COG2133	pyrroloquinoline quinone binding
GO174_RS04085	COG3706	GGDEF domain
GO174_RS04085	COG0745	RESPONSE REGULATOR receiver
GO174_RS04100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO174_RS04105	COG0072	phenylalanine-tRNA ligase activity
GO174_RS04105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO174_RS04110	COG0776	regulation of translation
GO174_RS04120	COG0500	methyltransferase
GO174_RS04130	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GO174_RS04150	COG5001	Diguanylate cyclase
GO174_RS04150	COG3300	MHYT domain
GO174_RS04155	COG0295	cytidine deaminase activity
GO174_RS04160	COG1346	cytolysis
GO174_RS04170	COG2925	Exonuclease
GO174_RS04185	COG0702	epimerase
GO174_RS04190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO174_RS04195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GO174_RS04200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GO174_RS04215	COG2988	succinylglutamate desuccinylase activity
GO174_RS04220	COG4139	cobalamin transport
GO174_RS04225	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GO174_RS04275	COG0583	DNA-binding transcription factor activity
GO174_RS04285	COG1451	nucleotide metabolic process
GO174_RS04300	COG3063	Type IV pilus biogenesis stability protein PilW
GO174_RS04305	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO174_RS04325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO174_RS04340	COG3290	protein histidine kinase activity
GO174_RS04345	COG4565	transcriptional regulatory protein
GO174_RS04355	COG0784	Response regulator, receiver
GO174_RS04355	COG0835	chemotaxis
GO174_RS04370	COG3706	GGDEF domain
GO174_RS04370	COG0745	RESPONSE REGULATOR receiver
GO174_RS04410	COG1278	Cold shock
GO174_RS04445	COG0668	transmembrane transport
GO174_RS04460	COG0745	RESPONSE REGULATOR receiver
GO174_RS04465	COG5002	protein histidine kinase activity
GO174_RS04470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GO174_RS04485	COG2010	Cytochrome c
GO174_RS04505	COG3391	amine dehydrogenase activity
GO174_RS04510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO174_RS04515	COG1254	Belongs to the acylphosphatase family
GO174_RS04520	COG2920	part of a sulfur-relay system
GO174_RS04525	COG0670	Belongs to the BI1 family
GO174_RS04530	COG1126	abc transporter atp-binding protein
GO174_RS04535	COG0765	amino acid transport
GO174_RS04540	COG4597	amino acid ABC transporter
GO174_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO174_RS04555	COG0561	phosphatase activity
GO174_RS04560	COG0602	queuosine metabolic process
GO174_RS04570	COG3005	denitrification pathway
GO174_RS04585	COG0745	RESPONSE REGULATOR receiver
GO174_RS04585	COG3706	GGDEF domain
GO174_RS04605	COG2999	glutathione oxidoreductase activity
GO174_RS04620	COG5001	Diguanylate cyclase
GO174_RS04620	COG3300	MHYT domain
GO174_RS04630	COG3706	GGDEF domain
GO174_RS04635	COG0443	Heat shock 70 kDa protein
GO174_RS04650	COG3706	GGDEF domain
GO174_RS04675	COG3005	denitrification pathway
GO174_RS04685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO174_RS04690	COG1643	Atp-dependent helicase
GO174_RS04700	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GO174_RS04710	COG3501	Rhs element vgr protein
GO174_RS04735	COG1115	amino acid carrier protein
GO174_RS04760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO174_RS04765	COG0574	Belongs to the PEP-utilizing enzyme family
GO174_RS04765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO174_RS04780	COG2996	Protein conserved in bacteria
GO174_RS04785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO174_RS04785	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GO174_RS04790	COG3008	intermembrane lipid transfer
GO174_RS04795	COG2995	paraquat-inducible protein a
GO174_RS04800	COG1132	(ABC) transporter
GO174_RS04805	COG1956	GAF domain-containing protein
GO174_RS04830	COG0308	aminopeptidase N
GO174_RS04845	COG0167	dihydroorotate dehydrogenase activity
GO174_RS04855	COG0116	Belongs to the methyltransferase superfamily
GO174_RS04855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO174_RS04880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO174_RS04885	COG1067	ATP-dependent peptidase activity
GO174_RS04890	COG3120	sequence-specific DNA binding
GO174_RS04905	COG3422	double-strand break repair
GO174_RS04990	COG3278	Belongs to the heme-copper respiratory oxidase family
GO174_RS05005	COG2010	Cytochrome c
GO174_RS05030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO174_RS05035	COG0589	response to stress
GO174_RS05060	COG3842	ATPase activity
GO174_RS05065	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO174_RS05070	COG1177	transmembrane transport
GO174_RS05075	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO174_RS05080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO174_RS05085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO174_RS05090	COG0004	ammonium transporteR
GO174_RS05105	COG0437	4 iron, 4 sulfur cluster binding
GO174_RS05120	COG3381	protein complex oligomerization
GO174_RS05135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO174_RS05150	COG3852	Histidine kinase
GO174_RS05155	COG2204	response regulator
GO174_RS05165	COG4662	Binding-protein-dependent transport system inner membrane component
GO174_RS05170	COG3842	ATPase activity
GO174_RS05175	COG0746	molybdenum cofactor guanylyltransferase activity
GO174_RS05180	COG0303	'Molybdopterin
GO174_RS05190	COG1940	carbohydrate kinase activity
GO174_RS05205	COG0840	transmembrane signaling receptor activity
GO174_RS05210	COG0791	NLP P60 protein
GO174_RS05230	COG0307	riboflavin synthase, alpha
GO174_RS05245	COG1793	dna ligase
GO174_RS05250	COG4667	esterase of the alpha-beta hydrolase superfamily
GO174_RS05270	COG0848	biopolymer transport protein
GO174_RS05275	COG0811	peptide transport
GO174_RS05280	COG0811	peptide transport
GO174_RS05290	COG3040	lipid binding
GO174_RS05295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO174_RS05315	COG0395	ABC-type sugar transport system, permease component
GO174_RS05320	COG3842	ATPase activity
GO174_RS05325	COG1349	DNA-binding transcription factor activity
GO174_RS05330	COG0584	glycerophosphoryl diester phosphodiesterase
GO174_RS05340	COG2731	YhcH YjgK YiaL family protein
GO174_RS05360	COG0625	glutathione transferase activity
GO174_RS05370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GO174_RS05380	COG2200	EAL domain
GO174_RS05385	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO174_RS05400	COG2814	Major facilitator Superfamily
GO174_RS05405	COG1566	PFAM secretion protein HlyD family protein
GO174_RS05420	COG2828	Protein conserved in bacteria
GO174_RS05425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GO174_RS05430	COG0372	Belongs to the citrate synthase family
GO174_RS05435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GO174_RS05445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO174_RS05445	COG2169	Transcriptional regulator
GO174_RS05480	COG1129	ABC transporter
GO174_RS05490	COG3250	beta-galactosidase activity
GO174_RS05500	COG2991	Protein conserved in bacteria
GO174_RS05505	COG0778	Nitroreductase
GO174_RS05510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO174_RS05515	COG0583	DNA-binding transcription factor activity
GO174_RS05525	COG4191	Histidine kinase
GO174_RS05525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO174_RS05550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO174_RS05555	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GO174_RS05560	COG3768	UPF0283 membrane protein
GO174_RS05565	COG3106	COG3106 Predicted ATPase
GO174_RS05580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO174_RS05595	COG0494	nUDIX hydrolase
GO174_RS05600	COG0814	amino acid
GO174_RS05605	COG1760	l-serine dehydratase
GO174_RS05610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO174_RS05615	COG0577	efflux transmembrane transporter activity
GO174_RS05615	COG1136	(ABC) transporter
GO174_RS05620	COG1538	Outer membrane efflux protein
GO174_RS05625	COG0720	synthase
GO174_RS05630	COG0840	transmembrane signaling receptor activity
GO174_RS05635	COG0017	Asparaginyl-tRNA synthetase
GO174_RS05650	COG1448	Aminotransferase
GO174_RS05660	COG0517	IMP dehydrogenase activity
GO174_RS05665	COG2176	DNA-directed DNA polymerase activity
GO174_RS05670	COG0840	transmembrane signaling receptor activity
GO174_RS05675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO174_RS05680	COG1846	Transcriptional regulator
GO174_RS05685	COG2197	response regulator
GO174_RS05700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO174_RS05715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO174_RS05720	COG3108	Peptidase M15
GO174_RS05725	COG2989	Protein conserved in bacteria
GO174_RS05750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO174_RS05770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO174_RS05800	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO174_RS05805	COG3265	gluconokinase activity
GO174_RS05820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO174_RS05870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO174_RS05885	COG4181	ATPase activity
GO174_RS05890	COG0534	Mate efflux family protein
GO174_RS05895	COG0702	epimerase
GO174_RS05905	COG2814	Major facilitator Superfamily
GO174_RS05915	COG1061	Type III restriction enzyme res subunit
GO174_RS05925	COG0745	RESPONSE REGULATOR receiver
GO174_RS05930	COG2205	protein histidine kinase activity
GO174_RS05935	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO174_RS05970	COG0714	Associated with various cellular activities
GO174_RS05975	COG0641	radical SAM
GO174_RS05980	COG3119	arylsulfatase activity
GO174_RS05990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO174_RS06000	COG1278	Cold shock
GO174_RS06015	COG3706	GGDEF domain
GO174_RS06030	COG0814	amino acid
GO174_RS06040	COG1131	(ABC) transporter
GO174_RS06045	COG0842	Transport permease protein
GO174_RS06055	COG3313	Fe-S protein
GO174_RS06065	COG4134	Bacterial extracellular solute-binding protein
GO174_RS06070	COG4135	transport system, permease component
GO174_RS06075	COG4136	ATPase activity
GO174_RS06080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO174_RS06085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO174_RS06095	COG0564	pseudouridine synthase activity
GO174_RS06115	COG0733	neurotransmitter:sodium symporter activity
GO174_RS06125	COG0626	cystathionine gamma-synthase activity
GO174_RS06155	COG0519	Catalyzes the synthesis of GMP from XMP
GO174_RS06165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO174_RS06170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO174_RS06185	COG1842	Phage shock protein A
GO174_RS06190	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO174_RS06200	COG4168	peptide transport system, permease
GO174_RS06205	COG4171	peptide transport system, permease
GO174_RS06215	COG4172	Belongs to the ABC transporter superfamily
GO174_RS06230	COG1227	inorganic diphosphatase activity
GO174_RS06250	COG0243	molybdopterin cofactor binding
GO174_RS06255	COG3005	denitrification pathway
GO174_RS06260	COG4459	periplasmic nitrate reductase
GO174_RS06265	COG0390	transport system, permease component
GO174_RS06270	COG2116	formate transmembrane transporter activity
GO174_RS06290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO174_RS06295	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GO174_RS06300	COG1435	thymidine kinase activity
GO174_RS06315	COG4106	trans-aconitate 2-methyltransferase activity
GO174_RS06320	COG0500	methyltransferase
GO174_RS06325	COG0189	ligase activity
GO174_RS06325	COG4067	protein conserved in archaea
GO174_RS06335	COG0189	ligase activity
GO174_RS06340	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GO174_RS06345	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GO174_RS06350	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GO174_RS06355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO174_RS06360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GO174_RS06365	COG0745	RESPONSE REGULATOR receiver
GO174_RS06370	COG3381	protein complex oligomerization
GO174_RS06375	COG1609	Transcriptional regulator
GO174_RS06380	COG3070	regulator of competence-specific genes
GO174_RS06400	COG0297	glycogen (starch) synthase activity
GO174_RS06405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO174_RS06410	COG0745	RESPONSE REGULATOR receiver
GO174_RS06410	COG3706	GGDEF domain
GO174_RS06415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO174_RS06425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO174_RS06435	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GO174_RS06440	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GO174_RS06445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GO174_RS06450	COG0542	response to heat
GO174_RS06455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GO174_RS06460	COG1278	Cold shock
GO174_RS06470	COG1187	pseudouridine synthase activity
GO174_RS06475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO174_RS06475	COG0140	phosphoribosyl-ATP diphosphatase activity
GO174_RS06485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO174_RS06490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO174_RS06495	COG0131	Imidazoleglycerol-phosphate dehydratase
GO174_RS06495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO174_RS06500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO174_RS06505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO174_RS06510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO174_RS06520	COG1757	Na H antiporter
GO174_RS06525	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO174_RS06530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO174_RS06535	COG0482	sulfurtransferase activity
GO174_RS06540	COG2915	High frequency lysogenization protein hflD homolog
GO174_RS06545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO174_RS06565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO174_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS06590	COG0501	Belongs to the peptidase M48B family
GO174_RS06595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GO174_RS06600	COG2226	methyltransferase
GO174_RS06610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO174_RS06615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO174_RS06625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO174_RS06625	COG2146	nitrite reductase [NAD(P)H] activity
GO174_RS06630	COG1116	anion transmembrane transporter activity
GO174_RS06635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO174_RS06640	COG1116	anion transmembrane transporter activity
GO174_RS06640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO174_RS06655	COG1648	precorrin-2 dehydrogenase activity
GO174_RS06655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO174_RS06660	COG0243	molybdopterin cofactor binding
GO174_RS06670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO174_RS06675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO174_RS06680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO174_RS06685	COG0653	protein targeting
GO174_RS06700	COG3706	GGDEF domain
GO174_RS06710	COG4120	Belongs to the binding-protein-dependent transport system permease family
GO174_RS06720	COG3092	negative regulation of chromosome organization
GO174_RS06725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO174_RS06730	COG0857	belongs to the CobB CobQ family
GO174_RS06730	COG0280	phosphate acetyltransferase
GO174_RS06735	COG3174	membrane
GO174_RS06740	COG0435	Glutathione S-transferase
GO174_RS06755	COG0444	Belongs to the ABC transporter superfamily
GO174_RS06760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO174_RS06765	COG0601	transmembrane transport
GO174_RS06795	COG0318	PFAM AMP-dependent synthetase and ligase
GO174_RS06795	COG0204	Acyl-transferase
GO174_RS06800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO174_RS06805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO174_RS06815	COG0318	PFAM AMP-dependent synthetase and ligase
GO174_RS06825	COG1216	Glycosyl transferase, family 2
GO174_RS06830	COG2986	histidine ammonia-lyase
GO174_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS06880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO174_RS06890	COG2200	EAL domain
GO174_RS06890	COG2199	diguanylate cyclase activity
GO174_RS06890	COG2202	Pas domain
GO174_RS06895	COG1621	beta-fructofuranosidase activity
GO174_RS06905	COG1263	PTS System
GO174_RS06905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO174_RS06915	COG0745	RESPONSE REGULATOR receiver
GO174_RS06925	COG2207	Transcriptional regulator
GO174_RS06925	COG3708	Transcriptional regulator
GO174_RS06930	COG2814	Major facilitator Superfamily
GO174_RS06935	COG1566	PFAM secretion protein HlyD family protein
GO174_RS06940	COG1538	Outer membrane efflux protein
GO174_RS06950	COG0747	negative chemotaxis
GO174_RS06955	COG0601	transmembrane transport
GO174_RS06960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO174_RS06970	COG0351	phosphomethylpyrimidine kinase
GO174_RS06980	COG0352	thiamine-phosphate diphosphorylase activity
GO174_RS06985	COG1741	Belongs to the pirin family
GO174_RS06990	COG2723	6-phospho-beta-galactosidase activity
GO174_RS06995	COG1609	Transcriptional regulator
GO174_RS07005	COG1120	ATPase activity
GO174_RS07010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO174_RS07020	COG1629	transport
GO174_RS07020	COG4774	siderophore transport
GO174_RS07025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO174_RS07030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO174_RS07035	COG4592	Periplasmic binding protein
GO174_RS07050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO174_RS07050	COG2226	methyltransferase
GO174_RS07050	COG3433	isochorismatase activity
GO174_RS07055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO174_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS07065	COG1169	isochorismate synthase
GO174_RS07070	COG1021	2,3-dihydroxybenzoate-AMP ligase
GO174_RS07080	COG2814	Major facilitator Superfamily
GO174_RS07085	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO174_RS07125	COG1294	oxidase, subunit
GO174_RS07130	COG1271	oxidase subunit
GO174_RS07135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO174_RS07150	COG3258	Cytochrome c
GO174_RS07155	COG2863	cytochrome
GO174_RS07200	COG2194	sulfuric ester hydrolase activity
GO174_RS07205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO174_RS07210	COG1368	sulfuric ester hydrolase activity
GO174_RS07215	COG0513	Belongs to the DEAD box helicase family
GO174_RS07225	COG0671	phosphoesterase, PA-phosphatase related
GO174_RS07230	COG0745	RESPONSE REGULATOR receiver
GO174_RS07235	COG0642	Histidine kinase
GO174_RS07250	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO174_RS07255	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO174_RS07285	COG2207	Transcriptional regulator
GO174_RS07290	COG1881	PFAM PEBP family protein
GO174_RS07295	COG1013	pyruvate-flavodoxin oxidoreductase activity
GO174_RS07300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GO174_RS07300	COG0674	pyruvate-flavodoxin oxidoreductase activity
GO174_RS07305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO174_RS07310	COG2207	Transcriptional regulator
GO174_RS07335	COG1278	Cold shock
GO174_RS07345	COG0697	spore germination
GO174_RS07350	COG0431	NADPH-dependent FMN reductase
GO174_RS07390	COG2199	diguanylate cyclase activity
GO174_RS07390	COG2203	Gaf domain
GO174_RS07405	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GO174_RS07410	COG1946	Acyl-CoA thioesterase
GO174_RS07420	COG1522	sequence-specific DNA binding
GO174_RS07445	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO174_RS07460	COG2204	response regulator
GO174_RS07465	COG2885	chlorophyll binding
GO174_RS07485	COG1987	bacterial-type flagellum assembly
GO174_RS07495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO174_RS07510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO174_RS07515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GO174_RS07535	COG1580	Controls the rotational direction of flagella during chemotaxis
GO174_RS07540	COG1191	sigma factor activity
GO174_RS07545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO174_RS07550	COG1360	Flagellar Motor Protein
GO174_RS07560	COG3015	lipoprotein NlpE involved in copper resistance
GO174_RS07565	COG0702	epimerase
GO174_RS07615	COG1256	bacterial-type flagellum assembly
GO174_RS07615	COG4786	Flagellar basal body rod
GO174_RS07625	COG1706	bacterial-type flagellum-dependent cell motility
GO174_RS07630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO174_RS07635	COG4786	Flagellar basal body rod
GO174_RS07645	COG1749	Flagellar hook protein flgE
GO174_RS07650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO174_RS07655	COG1558	bacterial-type flagellum-dependent cell motility
GO174_RS07660	COG1815	bacterial-type flagellum-dependent cell motility
GO174_RS07680	COG1388	LysM domain
GO174_RS07680	COG0741	lytic transglycosylase activity
GO174_RS07685	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GO174_RS07705	COG0477	Major facilitator Superfamily
GO174_RS07710	COG2855	membrane
GO174_RS07725	COG1441	menaquinone biosynthetic process
GO174_RS07730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO174_RS07735	COG0596	Alpha beta hydrolase
GO174_RS07740	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GO174_RS07745	COG1169	isochorismate synthase
GO174_RS07750	COG0436	Aminotransferase
GO174_RS07755	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GO174_RS07760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GO174_RS07800	COG0616	signal peptide processing
GO174_RS07805	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS07820	COG0587	DNA-directed DNA polymerase activity
GO174_RS07825	COG0784	Response regulator, receiver
GO174_RS07825	COG0835	chemotaxis
GO174_RS07830	COG1940	carbohydrate kinase activity
GO174_RS07835	COG0469	pyruvate kinase activity
GO174_RS07840	COG4667	esterase of the alpha-beta hydrolase superfamily
GO174_RS07855	COG0733	neurotransmitter:sodium symporter activity
GO174_RS07870	COG1263	PTS System
GO174_RS07870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO174_RS07885	COG0084	hydrolase, TatD family'
GO174_RS07890	COG0470	DNA polymerase III
GO174_RS07895	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO174_RS07900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO174_RS07905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO174_RS07910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO174_RS07930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO174_RS07935	COG0416	fatty acid biosynthetic process
GO174_RS07945	COG1399	metal-binding, possibly nucleic acid-binding protein
GO174_RS07950	COG0424	maF-like protein
GO174_RS07955	COG0564	pseudouridine synthase activity
GO174_RS07960	COG1530	ribonuclease E activity
GO174_RS07970	COG0659	secondary active sulfate transmembrane transporter activity
GO174_RS07980	COG1454	alcohol dehydrogenase
GO174_RS07980	COG1012	belongs to the aldehyde dehydrogenase family
GO174_RS07985	COG2095	MarC family integral membrane protein
GO174_RS07990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO174_RS07995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO174_RS08000	COG1757	Na H antiporter
GO174_RS08010	COG3081	Nucleoid-associated protein
GO174_RS08020	COG3083	sulfuric ester hydrolase activity
GO174_RS08295	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO174_RS08310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO174_RS08350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO174_RS08355	COG2159	amidohydrolase
GO174_RS08360	COG0583	DNA-binding transcription factor activity
GO174_RS08375	COG0667	Aldo Keto reductase
GO174_RS08400	COG3384	dioxygenase
GO174_RS08405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO174_RS08410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GO174_RS08430	COG2853	Lipoprotein
GO174_RS08445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO174_RS08450	COG1138	Cytochrome C-type biogenesis protein
GO174_RS08455	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GO174_RS08460	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO174_RS08465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO174_RS08470	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO174_RS08475	COG4133	protoheme IX ABC transporter activity
GO174_RS08485	COG0835	chemotaxis
GO174_RS08495	COG1192	Involved in chromosome partitioning
GO174_RS08500	COG2201	protein-glutamate methylesterase activity
GO174_RS08505	COG2198	Histidine kinase
GO174_RS08505	COG0643	Histidine kinase
GO174_RS08510	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GO174_RS08525	COG0455	bacterial-type flagellum organization
GO174_RS08540	COG2062	phosphohistidine phosphatase, SixA
GO174_RS08550	COG3102	Protein conserved in bacteria
GO174_RS08555	COG0018	arginyl-trna synthetase
GO174_RS08575	COG1918	ferrous iron import across plasma membrane
GO174_RS08585	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GO174_RS08590	COG1121	(ABC) transporter
GO174_RS08595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO174_RS08610	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO174_RS08615	COG0567	Dehydrogenase, E1 component
GO174_RS08630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GO174_RS08635	COG2009	succinate dehydrogenase
GO174_RS08645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO174_RS08655	COG0033	Phosphoglucomutase
GO174_RS08660	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GO174_RS08665	COG0596	Alpha beta hydrolase
GO174_RS08680	COG1346	cytolysis
GO174_RS08685	COG1380	Effector of murein hydrolase LrgA
GO174_RS08690	COG0583	DNA-binding transcription factor activity
GO174_RS08700	COG0735	belongs to the Fur family
GO174_RS08705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO174_RS08710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO174_RS08715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO174_RS08720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GO174_RS08720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO174_RS08735	COG3101	peptidyl-lysine hydroxylation
GO174_RS08740	COG2860	membrane
GO174_RS08745	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS08750	COG0583	DNA-binding transcription factor activity
GO174_RS08755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO174_RS08760	COG2890	protein-(glutamine-N5) methyltransferase activity
GO174_RS08780	COG1987	bacterial-type flagellum assembly
GO174_RS08830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO174_RS08840	COG1677	Flagellar hook-basal body complex protein FliE
GO174_RS08845	COG2204	response regulator
GO174_RS08850	COG4191	Histidine kinase
GO174_RS08855	COG2204	response regulator
GO174_RS08860	COG1516	flagellar protein fliS
GO174_RS08870	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GO174_RS08875	COG1334	flagellar protein FlaG
GO174_RS08880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO174_RS08885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO174_RS08895	COG2837	iron assimilation
GO174_RS08915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO174_RS08925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO174_RS08935	COG1393	Belongs to the ArsC family
GO174_RS08940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO174_RS08945	COG1876	peptidase activity
GO174_RS08955	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GO174_RS08960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO174_RS08965	COG2716	regulation of RNA biosynthetic process
GO174_RS08995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO174_RS09035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO174_RS09040	COG0668	transmembrane transport
GO174_RS09075	COG4783	chaperone-mediated protein folding
GO174_RS09080	COG1393	Belongs to the ArsC family
GO174_RS09100	COG2233	PERMEase
GO174_RS09110	COG0737	Belongs to the 5'-nucleotidase family
GO174_RS09120	COG2912	Transglutaminase-like superfamily
GO174_RS09125	COG3094	Invasion gene expression up-regulator, SirB
GO174_RS09130	COG2890	protein-(glutamine-N5) methyltransferase activity
GO174_RS09135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GO174_RS09140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GO174_RS09145	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GO174_RS09155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO174_RS09160	COG0193	aminoacyl-tRNA hydrolase activity
GO174_RS09260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO174_RS09275	COG1705	Flagellar rod assembly protein muramidase FlgJ
GO174_RS09275	COG3951	Flagellar rod assembly protein muramidase FlgJ
GO174_RS09280	COG1706	bacterial-type flagellum-dependent cell motility
GO174_RS09285	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO174_RS09290	COG4786	Flagellar basal body rod
GO174_RS09295	COG4787	bacterial-type flagellum-dependent cell motility
GO174_RS09300	COG1749	Flagellar hook protein flgE
GO174_RS09305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO174_RS09310	COG1558	bacterial-type flagellum-dependent cell motility
GO174_RS09315	COG1815	bacterial-type flagellum-dependent cell motility
GO174_RS09320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GO174_RS09325	COG0835	chemotaxis
GO174_RS09325	COG0784	Response regulator, receiver
GO174_RS09335	COG2747	anti-sigma28 factor FlgM
GO174_RS09365	COG4695	Portal protein
GO174_RS09455	COG2194	sulfuric ester hydrolase activity
GO174_RS09460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO174_RS09480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO174_RS09485	COG2608	mercury ion transmembrane transporter activity
GO174_RS09485	COG2217	Heavy metal translocating P-type atpase
GO174_RS09515	COG2840	Smr protein MutS2
GO174_RS09520	COG1187	pseudouridine synthase activity
GO174_RS09525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO174_RS09530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO174_RS09535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO174_RS09540	COG0121	glutamine amidotransferase
GO174_RS09545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO174_RS09550	COG1960	acyl-CoA dehydrogenase activity
GO174_RS09560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO174_RS09565	COG0328	RNA-DNA hybrid ribonuclease activity
GO174_RS09570	COG2226	methyltransferase
GO174_RS09575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO174_RS09580	COG1388	LysM domain
GO174_RS09580	COG0741	lytic transglycosylase activity
GO174_RS09595	COG0347	Belongs to the P(II) protein family
GO174_RS09605	COG0037	tRNA processing
GO174_RS09610	COG0825	malonyl-CoA metabolic process
GO174_RS09615	COG0587	DNA-directed DNA polymerase activity
GO174_RS09635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO174_RS09640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO174_RS09645	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GO174_RS09655	COG0750	zinc metalloprotease
GO174_RS09660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO174_RS09665	COG0575	Belongs to the CDS family
GO174_RS09670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO174_RS09695	COG0024	Methionine aminopeptidase
GO174_RS09700	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GO174_RS09710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO174_RS09715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GO174_RS09720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO174_RS09740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO174_RS09740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO174_RS09745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO174_RS09750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO174_RS09755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO174_RS09770	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GO174_RS09775	COG2252	PERMEase
GO174_RS09780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO174_RS09790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO174_RS09800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO174_RS09805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO174_RS09810	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO174_RS09815	COG4067	protein conserved in archaea
GO174_RS09815	COG0189	ligase activity
GO174_RS09820	COG0189	ligase activity
GO174_RS09830	COG0733	neurotransmitter:sodium symporter activity
GO174_RS09835	COG4251	negative regulation of phosphorylation
GO174_RS09835	COG5001	Diguanylate cyclase
GO174_RS09835	COG3706	GGDEF domain
GO174_RS09835	COG2203	Gaf domain
GO174_RS09845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO174_RS09860	COG1477	protein flavinylation
GO174_RS09865	COG2871	sodium ion transport
GO174_RS09870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO174_RS09875	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO174_RS09885	COG1805	sodium ion transport
GO174_RS09890	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO174_RS09895	COG0271	Belongs to the BolA IbaG family
GO174_RS09975	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GO174_RS09980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO174_RS09985	COG0590	tRNA wobble adenosine to inosine editing
GO174_RS09995	COG0542	response to heat
GO174_RS10005	COG0564	pseudouridine synthase activity
GO174_RS10010	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO174_RS10015	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO174_RS10020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO174_RS10025	COG1605	Chorismate mutase
GO174_RS10025	COG0077	Prephenate dehydratase
GO174_RS10030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO174_RS10035	COG5001	Diguanylate cyclase
GO174_RS10040	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GO174_RS10055	COG0488	(ABC) transporter
GO174_RS10065	COG0287	Prephenate dehydrogenase
GO174_RS10065	COG1605	Chorismate mutase
GO174_RS10070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO174_RS10075	COG3275	phosphorelay sensor kinase activity
GO174_RS10080	COG3279	Response regulator of the LytR AlgR family
GO174_RS10090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GO174_RS10095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GO174_RS10110	COG1966	Carbon starvation protein
GO174_RS10115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO174_RS10120	COG1047	Peptidyl-prolyl cis-trans
GO174_RS10125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GO174_RS10130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO174_RS10135	COG0196	riboflavin kinase activity
GO174_RS10140	COG0728	peptidoglycan biosynthetic process
GO174_RS10150	COG0640	Transcriptional regulator
GO174_RS10155	COG0583	DNA-binding transcription factor activity
GO174_RS10160	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO174_RS10165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GO174_RS10175	COG0730	response to heat
GO174_RS10185	COG0494	nUDIX hydrolase
GO174_RS10190	COG3066	DNA modification
GO174_RS10200	COG0667	Aldo Keto reductase
GO174_RS10210	COG2204	response regulator
GO174_RS10215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GO174_RS10235	COG0513	Belongs to the DEAD box helicase family
GO174_RS10240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GO174_RS10260	COG3153	acetyltransferase
GO174_RS10285	COG0534	Mate efflux family protein
GO174_RS10310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO174_RS10315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO174_RS10325	COG0195	Participates in both transcription termination and antitermination
GO174_RS10330	COG0779	Required for maturation of 30S ribosomal subunits
GO174_RS10345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO174_RS10350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO174_RS10355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO174_RS10360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO174_RS10370	COG1534	Rna-binding protein
GO174_RS10375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO174_RS10380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GO174_RS10385	COG2027	D-alanyl-D-alanine carboxypeptidase
GO174_RS10390	COG2239	Acts as a magnesium transporter
GO174_RS10400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO174_RS10405	COG0739	heme binding
GO174_RS10420	COG0316	Belongs to the HesB IscA family
GO174_RS10425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO174_RS10435	COG0628	permease
GO174_RS10450	COG0747	negative chemotaxis
GO174_RS10460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO174_RS10465	COG0444	Belongs to the ABC transporter superfamily
GO174_RS10470	COG4608	Belongs to the ABC transporter superfamily
GO174_RS10480	COG2971	BadF BadG BcrA BcrD
GO174_RS10495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO174_RS10500	COG3842	ATPase activity
GO174_RS10510	COG1840	ABC-type Fe3 transport system, periplasmic component
GO174_RS10515	COG0004	ammonium transporteR
GO174_RS10520	COG0347	Belongs to the P(II) protein family
GO174_RS10525	COG3112	Uncharacterised protein family (UPF0231)
GO174_RS10530	COG1049	propionate catabolic process, 2-methylcitrate cycle
GO174_RS10535	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO174_RS10540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO174_RS10545	COG1643	Atp-dependent helicase
GO174_RS10550	COG1489	DNA binding
GO174_RS10555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO174_RS10560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO174_RS10570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO174_RS10575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO174_RS10580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO174_RS10585	COG0842	Transport permease protein
GO174_RS10590	COG1131	(ABC) transporter
GO174_RS10595	COG0288	reversible hydration of carbon dioxide
GO174_RS10610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO174_RS10615	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO174_RS10620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GO174_RS10625	COG2186	Transcriptional regulator
GO174_RS10630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO174_RS10635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO174_RS10640	COG4974	Belongs to the 'phage' integrase family
GO174_RS10645	COG0716	FMN binding
GO174_RS10665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO174_RS10670	COG1459	type II secretion system
GO174_RS10685	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GO174_RS10690	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GO174_RS10695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO174_RS10700	COG0187	DNA topoisomerase II activity
GO174_RS10705	COG3150	esterase
GO174_RS10715	COG3151	Protein conserved in bacteria
GO174_RS10720	COG0494	nUDIX hydrolase
GO174_RS10725	COG1538	Outer membrane efflux protein
GO174_RS10730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GO174_RS10730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GO174_RS10735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO174_RS10745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO174_RS10750	COG3025	triphosphatase activity
GO174_RS10755	COG1392	Phosphate transport regulator
GO174_RS10760	COG0306	phosphate transporter
GO174_RS10765	COG4991	sh3 domain protein
GO174_RS10775	COG3409	Peptidoglycan-binding domain 1 protein
GO174_RS10775	COG3267	Type II secretory pathway component ExeA
GO174_RS10780	COG0617	tRNA 3'-terminal CCA addition
GO174_RS10785	COG0148	phosphopyruvate hydratase activity
GO174_RS10790	COG0504	CTP synthase activity
GO174_RS10795	COG3956	TIGRFAM MazG family protein
GO174_RS10800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO174_RS10805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO174_RS10815	COG0736	holo-[acyl-carrier-protein] synthase activity
GO174_RS10820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GO174_RS10825	COG1381	Involved in DNA repair and RecF pathway recombination
GO174_RS10830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GO174_RS10835	COG0571	ribonuclease III activity
GO174_RS10840	COG0681	Belongs to the peptidase S26 family
GO174_RS10845	COG0481	GTPase activity
GO174_RS10850	COG3086	response to oxidative stress
GO174_RS10865	COG1595	DNA-templated transcription, initiation
GO174_RS10870	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GO174_RS10880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GO174_RS10885	COG0354	folic acid binding
GO174_RS10900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO174_RS10905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO174_RS10915	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GO174_RS10925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO174_RS10935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO174_RS10940	COG0440	acetolactate synthase activity
GO174_RS10945	COG0028	Belongs to the TPP enzyme family
GO174_RS10950	COG1022	Amp-dependent synthetase and ligase
GO174_RS10955	COG0583	DNA-binding transcription factor activity
GO174_RS10975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO174_RS10980	COG0473	3-isopropylmalate dehydrogenase activity
GO174_RS10985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO174_RS11035	COG3437	response regulator, receiver
GO174_RS11045	COG2200	EAL domain
GO174_RS11045	COG2199	diguanylate cyclase activity
GO174_RS11045	COG2203	Gaf domain
GO174_RS11060	COG1280	lysine exporter protein (LysE YggA)
GO174_RS11065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO174_RS11070	COG1279	arginine transmembrane transporter activity
GO174_RS11130	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO174_RS11135	COG3706	GGDEF domain
GO174_RS11195	COG3706	GGDEF domain
GO174_RS11205	COG0795	lipopolysaccharide-transporting ATPase activity
GO174_RS11210	COG0795	lipopolysaccharide-transporting ATPase activity
GO174_RS11225	COG0525	valine-tRNA ligase activity
GO174_RS11230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO174_RS11235	COG0564	pseudouridine synthase activity
GO174_RS11245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO174_RS11255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GO174_RS11260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO174_RS11265	COG0540	Belongs to the ATCase OTCase family
GO174_RS11270	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GO174_RS11275	COG0251	oxidation-reduction process
GO174_RS11280	COG0204	Acyl-transferase
GO174_RS11285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO174_RS11290	COG5007	Belongs to the BolA IbaG family
GO174_RS11295	COG3113	response to antibiotic
GO174_RS11300	COG2854	intermembrane phospholipid transfer
GO174_RS11305	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO174_RS11310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GO174_RS11315	COG1127	ABC transporter
GO174_RS11325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO174_RS11325	COG0517	IMP dehydrogenase activity
GO174_RS11330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GO174_RS11340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GO174_RS11345	COG1137	ATPase activity
GO174_RS11355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO174_RS11360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO174_RS11370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO174_RS11375	COG2239	Acts as a magnesium transporter
GO174_RS11380	COG0312	modulator of DNA gyrase
GO174_RS11385	COG3028	Belongs to the UPF0307 family
GO174_RS11390	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GO174_RS11395	COG1178	ABC-type Fe3 transport system permease component
GO174_RS11400	COG4143	(ABC) transporter
GO174_RS11405	COG0163	prenyltransferase activity
GO174_RS11410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO174_RS11415	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GO174_RS11420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GO174_RS11425	COG2105	PFAM AIG2 family protein
GO174_RS11435	COG0729	surface antigen
GO174_RS11440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO174_RS11445	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GO174_RS11460	COG1136	(ABC) transporter
GO174_RS11460	COG0577	efflux transmembrane transporter activity
GO174_RS11480	COG0529	Catalyzes the synthesis of activated sulfate
GO174_RS11485	COG0490	domain, Protein
GO174_RS11485	COG0471	metal ion transport
GO174_RS11490	COG2895	sulfate adenylyltransferase (ATP) activity
GO174_RS11495	COG0175	sulfate reduction
GO174_RS11500	COG1648	precorrin-2 dehydrogenase activity
GO174_RS11500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO174_RS11505	COG0737	Belongs to the 5'-nucleotidase family
GO174_RS11515	COG0513	Belongs to the DEAD box helicase family
GO174_RS11520	COG2153	protein acetylation
GO174_RS11525	COG0697	spore germination
GO174_RS11530	COG3061	Opacity-associated protein A
GO174_RS11535	COG0545	Peptidyl-prolyl cis-trans isomerase
GO174_RS11545	COG0203	ribosomal protein L17
GO174_RS11550	COG0202	RNA polymerase activity
GO174_RS11555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO174_RS11560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO174_RS11575	COG0201	protein transport
GO174_RS11585	COG1841	ribosomal large subunit assembly
GO174_RS11595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO174_RS11600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO174_RS11605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO174_RS11610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO174_RS11615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO174_RS11620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GO174_RS11625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO174_RS11635	COG0255	Belongs to the universal ribosomal protein uL29 family
GO174_RS11650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GO174_RS11655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GO174_RS11665	COG0089	rRNA binding
GO174_RS11670	COG0088	Forms part of the polypeptide exit tunnel
GO174_RS11675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO174_RS11680	COG0051	transcription antitermination factor activity, RNA binding
GO174_RS11685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO174_RS11690	COG0557	exoribonuclease II activity
GO174_RS11695	COG3083	sulfuric ester hydrolase activity
GO174_RS11700	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GO174_RS11705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GO174_RS11715	COG1047	Peptidyl-prolyl cis-trans
GO174_RS11720	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GO174_RS11730	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO174_RS11735	COG0488	(ABC) transporter
GO174_RS11745	COG0429	hydrolase of the alpha beta-hydrolase fold
GO174_RS11755	COG3954	Phosphoribulokinase
GO174_RS11760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO174_RS11770	COG1012	belongs to the aldehyde dehydrogenase family
GO174_RS11780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO174_RS11790	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO174_RS11800	COG0180	Tryptophanyl-tRNA synthetase
GO174_RS11810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO174_RS11815	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO174_RS11825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO174_RS11860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GO174_RS11870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO174_RS11870	COG0678	peroxiredoxin activity
GO174_RS11880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO174_RS11880	COG0165	Argininosuccinate lyase
GO174_RS11890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO174_RS11895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO174_RS11900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO174_RS11905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GO174_RS11910	COG1695	Transcriptional regulator
GO174_RS11915	COG1045	serine acetyltransferase
GO174_RS11920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO174_RS11925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GO174_RS11930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO174_RS11935	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GO174_RS11940	COG1053	succinate dehydrogenase
GO174_RS11945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO174_RS11950	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO174_RS11955	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO174_RS11960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO174_RS11965	COG1509	lysine 2,3-aminomutase activity
GO174_RS11970	COG1285	pathogenesis
GO174_RS11980	COG1119	ATPase activity
GO174_RS11995	COG0459	protein refolding
GO174_RS12000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GO174_RS12025	COG0149	triose-phosphate isomerase activity
GO174_RS12035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO174_RS12040	COG1575	Belongs to the MenA family. Type 1 subfamily
GO174_RS12045	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO174_RS12050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GO174_RS12060	COG1609	Transcriptional regulator
GO174_RS12065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO174_RS12070	COG0254	rRNA binding
GO174_RS12075	COG0281	malic enzyme
GO174_RS12085	COG0626	cystathionine gamma-synthase activity
GO174_RS12090	COG0527	aspartate kinase activity
GO174_RS12090	COG0460	homoserine dehydrogenase
GO174_RS12095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GO174_RS12105	COG1494	fructose-1,6-bisphosphatase
GO174_RS12110	COG0205	6-phosphofructokinase activity
GO174_RS12115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO174_RS12125	COG0745	RESPONSE REGULATOR receiver
GO174_RS12130	COG2205	protein histidine kinase activity
GO174_RS12135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO174_RS12140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO174_RS12145	COG3030	protein affecting phage T7 exclusion by the F plasmid
GO174_RS12150	COG3706	GGDEF domain
GO174_RS12155	COG1027	Aspartate ammonia-lyase
GO174_RS12160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO174_RS12165	COG1288	antiporter activity
GO174_RS12180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO174_RS12185	COG0540	Belongs to the ATCase OTCase family
GO174_RS12190	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GO174_RS12200	COG4232	protein-disulfide reductase activity
GO174_RS12210	COG3263	regulation of cellular component size
GO174_RS12220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO174_RS12225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO174_RS12230	COG0194	GDP metabolic process
GO174_RS12240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO174_RS12245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO174_RS12250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO174_RS12255	COG2233	PERMEase
GO174_RS12260	COG2205	protein histidine kinase activity
GO174_RS12265	COG0745	RESPONSE REGULATOR receiver
GO174_RS12270	COG0800	Aldolase
GO174_RS12275	COG2610	gluconate transmembrane transporter activity
GO174_RS12280	COG3265	gluconokinase activity
GO174_RS12285	COG0129	dihydroxy-acid dehydratase activity
GO174_RS12290	COG1609	Transcriptional regulator
GO174_RS12295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO174_RS12305	COG2183	response to ionizing radiation
GO174_RS12320	COG1040	competence protein
GO174_RS12325	COG0316	Belongs to the HesB IscA family
GO174_RS12325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO174_RS12330	COG0494	nUDIX hydrolase
GO174_RS12335	COG1218	3'(2'),5'-bisphosphate nucleotidase
GO174_RS12345	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GO174_RS12350	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GO174_RS12355	COG3156	type II secretion system protein K
GO174_RS12360	COG4795	General secretion pathway protein
GO174_RS12365	COG2165	general secretion pathway protein
GO174_RS12370	COG2165	general secretion pathway protein
GO174_RS12375	COG2165	general secretion pathway protein
GO174_RS12380	COG1459	type II secretion system
GO174_RS12385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO174_RS12395	COG3031	protein transport across the cell outer membrane
GO174_RS12400	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GO174_RS12405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GO174_RS12410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO174_RS12415	COG2982	Protein involved in outer membrane biogenesis
GO174_RS12420	COG0456	acetyltransferase
GO174_RS12425	COG1490	D-aminoacyl-tRNA deacylase activity
GO174_RS12450	COG0174	glutamine synthetase
GO174_RS12460	COG3852	Histidine kinase
GO174_RS12465	COG2204	response regulator
GO174_RS12470	COG5001	Diguanylate cyclase
GO174_RS12470	COG3300	MHYT domain
GO174_RS12475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO174_RS12560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO174_RS12575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO174_RS12670	COG0328	RNA-DNA hybrid ribonuclease activity
GO174_RS12720	COG0534	Mate efflux family protein
GO174_RS12730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO174_RS12735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO174_RS12740	COG2937	Belongs to the GPAT DAPAT family
GO174_RS12745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GO174_RS12750	COG3161	chorismate lyase activity
GO174_RS12755	COG1580	Controls the rotational direction of flagella during chemotaxis
GO174_RS12760	COG0705	Rhomboid family
GO174_RS12770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO174_RS12775	COG2177	Part of the ABC transporter FtsEX involved in
GO174_RS12780	COG2884	Cell division ATP-binding protein ftsE
GO174_RS12785	COG0552	protein localization to endoplasmic reticulum
GO174_RS12790	COG0742	ribosomal rna small subunit methyltransferase
GO174_RS12800	COG2095	MarC family integral membrane protein
GO174_RS12830	COG0783	Belongs to the Dps family
GO174_RS12845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO174_RS12850	COG0640	Transcriptional regulator
GO174_RS12855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO174_RS12860	COG1280	lysine exporter protein (LysE YggA)
GO174_RS12865	COG2267	carboxylic ester hydrolase activity
GO174_RS12870	COG0561	phosphatase activity
GO174_RS12890	COG2199	diguanylate cyclase activity
GO174_RS12890	COG3287	FIST C domain
GO174_RS12890	COG2200	EAL domain
GO174_RS12895	COG1011	Hydrolase
GO174_RS12900	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GO174_RS12910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GO174_RS12915	COG0019	diaminopimelate decarboxylase activity
GO174_RS12930	COG3072	Adenylate cyclase
GO174_RS12945	COG2959	enzyme of heme biosynthesis
GO174_RS12950	COG3071	HemY protein
GO174_RS12955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO174_RS12980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GO174_RS12985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO174_RS12985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO174_RS12990	COG0456	acetyltransferase
GO174_RS13000	COG0084	hydrolase, TatD family'
GO174_RS13005	COG0805	protein transport
GO174_RS13010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO174_RS13020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GO174_RS13025	COG3165	ubiquinone biosynthetic process from chorismate
GO174_RS13030	COG2226	methyltransferase
GO174_RS13035	COG1322	Protein conserved in bacteria
GO174_RS13060	COG2160	L-arabinose isomerase activity
GO174_RS13065	COG0235	Class ii aldolase
GO174_RS13070	COG1069	ribulokinase activity
GO174_RS13075	COG1879	ABC-type sugar transport system periplasmic component
GO174_RS13080	COG1129	ABC transporter
GO174_RS13085	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO174_RS13090	COG2081	HI0933 family
GO174_RS13100	COG1528	Iron-storage protein
GO174_RS13105	COG0589	response to stress
GO174_RS13120	COG0742	ribosomal rna small subunit methyltransferase
GO174_RS13125	COG5001	Diguanylate cyclase
GO174_RS13125	COG5002	protein histidine kinase activity
GO174_RS13130	COG1522	sequence-specific DNA binding
GO174_RS13150	COG0006	proline dipeptidase activity
GO174_RS13150	COG0006	proline dipeptidase activity
GO174_RS13180	COG0517	IMP dehydrogenase activity
GO174_RS13180	COG4175	Glycine betaine
GO174_RS13195	COG2022	thiamine diphosphate biosynthetic process
GO174_RS13195	COG2104	thiamine diphosphate biosynthetic process
GO174_RS13200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO174_RS13205	COG0352	thiamine-phosphate diphosphorylase activity
GO174_RS13210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GO174_RS13215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO174_RS13220	COG2132	Multicopper oxidase
GO174_RS13275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO174_RS13280	COG1739	Uncharacterized protein family UPF0029
GO174_RS13290	COG0183	Belongs to the thiolase family
GO174_RS13295	COG0583	DNA-binding transcription factor activity
GO174_RS13300	COG2814	Major facilitator Superfamily
GO174_RS13305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO174_RS13310	COG0765	amino acid transport
GO174_RS13320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO174_RS13325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GO174_RS13330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO174_RS13340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO174_RS13345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO174_RS13355	COG0356	it plays a direct role in the translocation of protons across the membrane
GO174_RS13360	COG3312	ion transport
GO174_RS13365	COG1475	DNA binding
GO174_RS13370	COG1192	Involved in chromosome partitioning
GO174_RS13375	COG0357	Ribosomal RNA small subunit methyltransferase G
GO174_RS13380	COG0445	tRNA wobble uridine modification
GO174_RS13385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO174_RS13390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GO174_RS13395	COG0706	membrane insertase activity
GO174_RS13400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO174_RS13410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GO174_RS13415	COG1126	abc transporter atp-binding protein
GO174_RS13430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GO174_RS13435	COG0592	DNA-directed DNA polymerase activity
GO174_RS13440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO174_RS13445	COG0187	DNA topoisomerase II activity
GO174_RS13450	COG0071	Belongs to the small heat shock protein (HSP20) family
GO174_RS13455	COG3977	Valine--pyruvate aminotransferase
GO174_RS13460	COG0751	glycine-tRNA ligase activity
GO174_RS13465	COG0752	glycyl-tRNA synthetase alpha subunit
GO174_RS13470	COG2119	membrane
GO174_RS13495	COG0604	alcohol dehydrogenase
GO174_RS13510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO174_RS13515	COG3978	acetolactate synthase activity
GO174_RS13525	COG0606	chelatase, subunit chli
GO174_RS13530	COG0204	Acyl-transferase
GO174_RS13535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO174_RS13540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO174_RS13550	COG3084	Protein conserved in bacteria
GO174_RS13560	COG4326	sporulation control protein
GO174_RS13565	COG1272	protein, Hemolysin III
GO174_RS13575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO174_RS13580	COG0569	domain protein
GO174_RS13585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO174_RS13585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO174_RS13595	COG0242	peptide deformylase activity
GO174_RS13600	COG1652	LysM domain
GO174_RS13605	COG0758	DNA mediated transformation
GO174_RS13610	COG2922	Belongs to the Smg family
GO174_RS13615	COG0551	DNA topoisomerase type I activity
GO174_RS13620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO174_RS13635	COG0408	coproporphyrinogen oxidase activity
GO174_RS13640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO174_RS13650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GO174_RS13690	COG0583	DNA-binding transcription factor activity
GO174_RS13700	COG2960	long-chain fatty acid transporting porin activity
GO174_RS13705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO174_RS13710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO174_RS13720	COG0210	DNA helicase
GO174_RS13755	COG4172	Belongs to the ABC transporter superfamily
GO174_RS13760	COG0747	negative chemotaxis
GO174_RS13770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO174_RS13780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO174_RS13785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO174_RS13800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO174_RS13805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GO174_RS13830	COG3220	belongs to the UPF0276 family
GO174_RS13840	COG0210	DNA helicase
GO174_RS13845	COG0405	Gamma-glutamyltransferase
GO174_RS13850	COG1280	lysine exporter protein (LysE YggA)
GO174_RS13860	COG2962	Rard protein
GO174_RS13865	COG0514	ATP-dependent DNA helicase (RecQ)
GO174_RS13880	COG1132	(ABC) transporter
GO174_RS13885	COG1120	ATPase activity
GO174_RS13890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO174_RS13935	COG0328	RNA-DNA hybrid ribonuclease activity
GO174_RS13945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO174_RS13955	COG1309	transcriptional regulator
GO174_RS14000	COG2003	Belongs to the UPF0758 family
GO174_RS14035	COG1561	YicC-like family, N-terminal region
GO174_RS14040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GO174_RS14045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO174_RS14050	COG1560	Kdo2-lipid A biosynthetic process
GO174_RS14055	COG1309	transcriptional regulator
GO174_RS14060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO174_RS14080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GO174_RS14090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO174_RS14105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GO174_RS14110	COG0438	transferase activity, transferring glycosyl groups
GO174_RS14115	COG0438	transferase activity, transferring glycosyl groups
GO174_RS14120	COG0463	Glycosyl transferase, family 2
GO174_RS14125	COG0859	PFAM glycosyl transferase family 9
GO174_RS14135	COG0438	transferase activity, transferring glycosyl groups
GO174_RS14140	COG1519	Transferase
GO174_RS14145	COG0859	PFAM glycosyl transferase family 9
GO174_RS14150	COG0859	PFAM glycosyl transferase family 9
GO174_RS14160	COG1560	Kdo2-lipid A biosynthetic process
GO174_RS14170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO174_RS14180	COG2089	acid synthase
GO174_RS14210	COG0367	asparagine synthase
GO174_RS14240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO174_RS14250	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GO174_RS14255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GO174_RS14260	COG1573	uracil-dna glycosylase
GO174_RS14265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO174_RS14270	COG3068	Protein conserved in bacteria
GO174_RS14275	COG0668	transmembrane transport
GO174_RS14280	COG1253	flavin adenine dinucleotide binding
GO174_RS14285	COG0776	regulation of translation
GO174_RS14295	COG0151	Belongs to the GarS family
GO174_RS14300	COG0138	bifunctional purine biosynthesis protein purh
GO174_RS14310	COG0789	Transcriptional regulator
GO174_RS14315	COG0840	transmembrane signaling receptor activity
GO174_RS14320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GO174_RS14325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO174_RS14330	COG2264	protein methyltransferase activity
GO174_RS14335	COG0439	Biotin carboxylase
GO174_RS14340	COG0511	ligase activity, forming carbon-carbon bonds
GO174_RS14345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GO174_RS14350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO174_RS14365	COG2814	Major facilitator Superfamily
GO174_RS14370	COG2198	Histidine kinase
GO174_RS14370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO174_RS14370	COG2205	protein histidine kinase activity
GO174_RS14370	COG0784	Response regulator, receiver
GO174_RS14375	COG0248	Ppx GppA phosphatase
GO174_RS14380	COG0513	Belongs to the DEAD box helicase family
GO174_RS14385	COG3118	belongs to the thioredoxin family
GO174_RS14390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GO174_RS14400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO174_RS14440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO174_RS14450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO174_RS14460	COG1072	(Pantothenic acid kinase))
GO174_RS14490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO174_RS14495	COG0250	Participates in transcription elongation, termination and antitermination
GO174_RS14500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GO174_RS14505	COG0081	regulation of translation
GO174_RS14510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO174_RS14520	COG0085	RNA polymerase activity
GO174_RS14525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO174_RS14530	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GO174_RS14535	COG2816	NAD+ diphosphatase activity
GO174_RS14555	COG4942	peptidase
GO174_RS14560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO174_RS14575	COG0490	domain, Protein
GO174_RS14575	COG0471	metal ion transport
GO174_RS14580	COG0688	phosphatidylethanolamine metabolic process
GO174_RS14585	COG1162	GTPase activity
GO174_RS14635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GO174_RS14640	COG0802	atpase or kinase
GO174_RS14650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GO174_RS14655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO174_RS14660	COG1923	regulation of RNA biosynthetic process
GO174_RS14665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO174_RS14670	COG0330	HflC and HflK could
GO174_RS14675	COG0330	HflC and HflK could
GO174_RS14680	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GO174_RS14685	COG2900	Belongs to the SlyX family
GO174_RS14695	COG0545	Peptidyl-prolyl cis-trans isomerase
GO174_RS14700	COG2964	Protein conserved in bacteria
GO174_RS14710	COG2923	Belongs to the DsrF TusC family
GO174_RS14715	COG2168	tRNA wobble position uridine thiolation
GO174_RS14725	COG0049	tRNA binding
GO174_RS14730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO174_RS14740	COG2906	2 iron, 2 sulfur cluster binding
GO174_RS14750	COG0360	Binds together with S18 to 16S ribosomal RNA
GO174_RS14755	COG2965	DNA replication, synthesis of RNA primer
GO174_RS14765	COG0359	binds to the 23S rRNA
GO174_RS14775	COG0305	Participates in initiation and elongation during chromosome replication
GO174_RS14780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO174_RS14785	COG0432	Pfam Uncharacterised protein family UPF0047
GO174_RS14790	COG0166	Belongs to the GPI family
GO174_RS14800	COG0735	belongs to the Fur family
GO174_RS14830	COG4386	tail sheath protein
GO174_RS14870	COG4695	Portal protein
GO174_RS15025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO174_RS15045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO174_RS15055	COG0175	sulfate reduction
GO174_RS15130	COG0646	methionine synthase
GO174_RS15130	COG1410	methionine synthase
GO174_RS15135	COG0527	aspartate kinase activity
GO174_RS15140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO174_RS15150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GO174_RS15165	COG0629	single-stranded DNA binding
GO174_RS15170	COG2200	EAL domain
GO174_RS15170	COG2199	diguanylate cyclase activity
GO174_RS15195	COG3409	Peptidoglycan-binding domain 1 protein
GO174_RS15195	COG3267	Type II secretory pathway component ExeA
GO174_RS15205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO174_RS15255	COG1077	Cell shape determining protein MreB Mrl
GO174_RS15260	COG1792	Involved in formation and maintenance of cell shape
GO174_RS15265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO174_RS15270	COG0424	maF-like protein
GO174_RS15275	COG1530	ribonuclease E activity
GO174_RS15355	COG1289	transmembrane transporter activity
GO174_RS15370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GO174_RS15375	COG4149	molybdate abc transporter
GO174_RS15380	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO174_RS15385	COG1492	cobalamin metabolic process
GO174_RS15405	COG0784	Response regulator, receiver
GO174_RS15405	COG5002	protein histidine kinase activity
GO174_RS15410	COG1879	ABC-type sugar transport system periplasmic component
GO174_RS15420	COG2827	Endonuclease containing a URI domain
GO174_RS15460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO174_RS15465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO174_RS15470	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GO174_RS15475	COG0247	lactate metabolic process
GO174_RS15490	COG0438	transferase activity, transferring glycosyl groups
GO174_RS15490	COG0297	glycogen (starch) synthase activity
GO174_RS15495	COG0438	transferase activity, transferring glycosyl groups
GO174_RS15520	COG1596	polysaccharide export
GO174_RS15530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO174_RS15545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO174_RS15550	COG3118	belongs to the thioredoxin family
GO174_RS15555	COG2814	Major facilitator Superfamily
GO174_RS15585	COG2116	formate transmembrane transporter activity
GO174_RS15590	COG2146	nitrite reductase [NAD(P)H] activity
GO174_RS15595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO174_RS15625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO174_RS15655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO174_RS15670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO174_RS15680	COG1070	Carbohydrate kinase
GO174_RS15690	COG2390	Transcriptional regulator
GO174_RS15700	COG1294	oxidase, subunit
GO174_RS15705	COG1271	oxidase subunit
GO174_RS15715	COG3781	membrane
GO174_RS15720	COG0583	DNA-binding transcription factor activity
GO174_RS15725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO174_RS15740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO174_RS15750	COG0330	HflC and HflK could
GO174_RS15775	COG2207	Transcriptional regulator
GO174_RS15775	COG1917	Cupin 2, conserved barrel domain protein
GO174_RS15780	COG0697	spore germination
GO174_RS15785	COG0583	DNA-binding transcription factor activity
GO174_RS15795	COG0463	Glycosyl transferase, family 2
GO174_RS15805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO174_RS15840	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GO174_RS15855	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GO174_RS15865	COG1309	transcriptional regulator
GO174_RS15870	COG0513	Belongs to the DEAD box helicase family
GO174_RS15875	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GO174_RS15880	COG0814	amino acid
GO174_RS15885	COG0840	transmembrane signaling receptor activity
GO174_RS15890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO174_RS15895	COG3447	MASE1 domain protein
GO174_RS15895	COG5002	protein histidine kinase activity
GO174_RS15895	COG5001	Diguanylate cyclase
GO174_RS15900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GO174_RS15910	COG1984	allophanate hydrolase subunit 2
GO174_RS15920	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GO174_RS15925	COG4181	ATPase activity
GO174_RS15935	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO174_RS15940	COG5001	Diguanylate cyclase
GO174_RS15940	COG1716	ATPase activity
GO174_RS15950	COG0484	heat shock protein binding
GO174_RS15970	COG0546	phosphoglycolate phosphatase activity
GO174_RS15985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO174_RS15990	COG5001	Diguanylate cyclase
GO174_RS15995	COG3706	GGDEF domain
GO174_RS16005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO174_RS16020	COG0509	glycine decarboxylation via glycine cleavage system
GO174_RS16025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO174_RS16025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO174_RS16045	COG3122	Protein conserved in bacteria
GO174_RS16090	COG1280	lysine exporter protein (LysE YggA)
GO174_RS16110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO174_RS16120	COG2985	domain, Protein
GO174_RS16135	COG0840	transmembrane signaling receptor activity
GO174_RS16150	COG0513	Belongs to the DEAD box helicase family
GO174_RS16155	COG1280	lysine exporter protein (LysE YggA)
GO174_RS16170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO174_RS16180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO174_RS16215	COG3338	carbonate dehydratase activity
GO174_RS16225	COG1566	PFAM secretion protein HlyD family protein
GO174_RS16240	COG1686	Belongs to the peptidase S11 family
GO174_RS16250	COG0765	amino acid transport
GO174_RS16265	COG1522	sequence-specific DNA binding
GO174_RS16275	COG1166	arginine decarboxylase activity
GO174_RS16285	COG4175	Glycine betaine
GO174_RS16290	COG4176	ABC-type proline glycine betaine transport system permease component
GO174_RS16295	COG2113	Glycine betaine
GO174_RS16315	COG2239	Acts as a magnesium transporter
GO174_RS16320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GO174_RS16325	COG0459	protein refolding
GO174_RS16335	COG0113	porphobilinogen synthase activity
GO174_RS16345	COG3437	response regulator, receiver
GO174_RS16345	COG0784	Response regulator, receiver
GO174_RS16355	COG0583	DNA-binding transcription factor activity
GO174_RS16365	COG0561	phosphatase activity
GO174_RS16370	COG0527	aspartate kinase activity
GO174_RS16375	COG0662	Cupin 2, conserved barrel domain protein
GO174_RS16380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO174_RS16385	COG0456	acetyltransferase
GO174_RS16395	COG0861	Integral membrane protein TerC family
GO174_RS16405	COG0534	Mate efflux family protein
GO174_RS16410	COG2154	pterin-4-alpha-carbinolamine dehydratase
GO174_RS16415	COG3186	Phenylalanine-4-hydroxylase
GO174_RS16420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO174_RS16430	COG0642	Histidine kinase
GO174_RS16435	COG0745	RESPONSE REGULATOR receiver
GO174_RS16465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO174_RS16490	COG2171	N-acyltransferase activity
GO174_RS16500	COG1765	OsmC-like protein
GO174_RS16515	COG5001	Diguanylate cyclase
GO174_RS16515	COG3300	MHYT domain
GO174_RS16520	COG0784	Response regulator, receiver
GO174_RS16520	COG2205	protein histidine kinase activity
GO174_RS16520	COG5002	protein histidine kinase activity
GO174_RS16545	COG2200	EAL domain
GO174_RS16550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO174_RS16580	COG1522	sequence-specific DNA binding
GO174_RS16585	COG0531	amino acid
GO174_RS16595	COG0748	coenzyme F420 binding
GO174_RS16600	COG3721	Heme iron utilization protein
GO174_RS16605	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GO174_RS16610	COG0811	peptide transport
GO174_RS16615	COG0848	biopolymer transport protein
GO174_RS16625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO174_RS16630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GO174_RS16660	COG3217	Mosc domain protein beta barrel domain protein
GO174_RS16660	COG0633	Ferredoxin
GO174_RS16665	COG0418	dihydroorotase activity
GO174_RS16670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO174_RS16675	COG2354	Protein conserved in bacteria
GO174_RS16695	COG1349	DNA-binding transcription factor activity
GO174_RS16735	COG3842	ATPase activity
GO174_RS16775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO174_RS16785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO174_RS16805	COG0517	IMP dehydrogenase activity
GO174_RS16810	COG1414	Transcriptional regulator
GO174_RS16815	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS16825	COG1917	Cupin 2, conserved barrel domain protein
GO174_RS16840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO174_RS16845	COG0800	Aldolase
GO174_RS16865	COG1175	transmembrane transport
GO174_RS16870	COG0395	ABC-type sugar transport system, permease component
GO174_RS16875	COG3842	ATPase activity
GO174_RS16880	COG1653	transport
GO174_RS16890	COG0534	Mate efflux family protein
GO174_RS16895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO174_RS16900	COG0823	Involved in the tonB-independent uptake of proteins
GO174_RS16905	COG0393	Putative heavy-metal-binding
GO174_RS16915	COG1522	sequence-specific DNA binding
GO174_RS16935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO174_RS16950	COG1942	4-Oxalocrotonate Tautomerase
GO174_RS16960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO174_RS16965	COG0784	Response regulator, receiver
GO174_RS16965	COG0835	chemotaxis
GO174_RS16970	COG2315	Protein conserved in bacteria
GO174_RS16975	COG1846	Transcriptional regulator
GO174_RS16985	COG3706	GGDEF domain
GO174_RS17005	COG3706	GGDEF domain
GO174_RS17030	COG5001	Diguanylate cyclase
GO174_RS17040	COG1741	Belongs to the pirin family
GO174_RS17045	COG3123	guanosine phosphorylase activity
GO174_RS17055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO174_RS17060	COG0569	domain protein
GO174_RS17065	COG0668	transmembrane transport
GO174_RS17070	COG2211	Major facilitator Superfamily
GO174_RS17080	COG1067	ATP-dependent peptidase activity
GO174_RS17090	COG4172	Belongs to the ABC transporter superfamily
GO174_RS17095	COG0583	DNA-binding transcription factor activity
GO174_RS17105	COG1304	FMN binding
GO174_RS17130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO174_RS17140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO174_RS17150	COG3152	Membrane
GO174_RS17170	COG0583	DNA-binding transcription factor activity
GO174_RS17185	COG1942	4-Oxalocrotonate Tautomerase
GO174_RS17195	COG0625	glutathione transferase activity
GO174_RS17200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO174_RS17205	COG0477	Major facilitator Superfamily
GO174_RS17210	COG0697	spore germination
GO174_RS17215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO174_RS17235	COG2169	Transcriptional regulator
GO174_RS17255	COG3447	MASE1 domain protein
GO174_RS17255	COG5002	protein histidine kinase activity
GO174_RS17255	COG5001	Diguanylate cyclase
GO174_RS17265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO174_RS17280	COG0109	protoheme IX farnesyltransferase activity
GO174_RS17285	COG1612	heme a metabolic process
GO174_RS17315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO174_RS17325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO174_RS17330	COG1902	pentaerythritol trinitrate reductase activity
GO174_RS17340	COG1280	lysine exporter protein (LysE YggA)
GO174_RS17360	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO174_RS17365	COG1846	Transcriptional regulator
GO174_RS17370	COG1764	response to oxidative stress
GO174_RS17405	COG1917	Cupin 2, conserved barrel domain protein
GO174_RS17405	COG2169	Transcriptional regulator
GO174_RS17425	COG1301	dicarboxylic acid transport
GO174_RS17430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO174_RS17440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO174_RS17445	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO174_RS17450	COG2259	Doxx family
GO174_RS17455	COG0402	S-adenosylhomocysteine deaminase activity
GO174_RS17480	COG0363	glucosamine-6-phosphate deaminase activity
GO174_RS17495	COG0739	heme binding
GO174_RS17500	COG2213	PTS system mannitol-specific
GO174_RS17500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO174_RS17510	COG3722	fumarate hydratase activity
GO174_RS17525	COG1473	amidohydrolase
GO174_RS17530	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GO174_RS17545	COG0095	Lipoate-protein ligase
GO174_RS17550	COG0443	Heat shock 70 kDa protein
GO174_RS17570	COG2176	DNA-directed DNA polymerase activity
GO174_RS17600	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO174_RS17615	COG1403	HNH endonuclease
GO174_RS17630	COG4221	oxidoreductase activity
GO174_RS17635	COG0583	DNA-binding transcription factor activity
GO174_RS17660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO174_RS17670	COG3304	Inner membrane component domain
GO174_RS17675	COG2329	Antibiotic biosynthesis monooxygenase
GO174_RS17690	COG2207	Transcriptional regulator
GO174_RS17690	COG1609	Transcriptional regulator
GO174_RS17695	COG1335	isochorismatase
GO174_RS17710	COG2910	NAD(P)H-binding
GO174_RS17715	COG0583	DNA-binding transcription factor activity
GO174_RS17730	COG1349	DNA-binding transcription factor activity
GO174_RS17735	COG2084	Dehydrogenase
GO174_RS17740	COG3395	kinase activity
GO174_RS17745	COG0235	Class ii aldolase
GO174_RS17750	COG3622	Belongs to the hyi family
GO174_RS17755	COG2610	gluconate transmembrane transporter activity
GO174_RS17760	COG1522	sequence-specific DNA binding
GO174_RS17765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO174_RS17770	COG0724	RNA recognition motif
GO174_RS17785	COG2226	methyltransferase
GO174_RS17790	COG0583	DNA-binding transcription factor activity
GO174_RS17795	COG0477	Major facilitator Superfamily
GO174_RS17800	COG0513	Belongs to the DEAD box helicase family
GO174_RS17810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO174_RS17825	COG0840	transmembrane signaling receptor activity
GO174_RS17855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GO174_RS17865	COG0259	pyridoxamine-phosphate oxidase activity
GO174_RS17895	COG0745	RESPONSE REGULATOR receiver
GO174_RS17910	COG2201	protein-glutamate methylesterase activity
GO174_RS17920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GO174_RS17925	COG0840	transmembrane signaling receptor activity
GO174_RS17930	COG0835	chemotaxis
GO174_RS17935	COG0835	chemotaxis
GO174_RS17940	COG2198	Histidine kinase
GO174_RS17940	COG0643	Histidine kinase
GO174_RS17945	COG0745	RESPONSE REGULATOR receiver
GO174_RS17955	COG1444	tRNA N-acetyltransferase activity
GO174_RS17960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO174_RS17995	COG0217	transcriptional regulatory protein
GO174_RS18010	COG2084	Dehydrogenase
GO174_RS18025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO174_RS18030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO174_RS18035	COG1845	cytochrome c oxidase, subunit III
GO174_RS18040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO174_RS18055	COG2909	trisaccharide binding
GO174_RS18060	COG0058	SHG alpha-glucan phosphorylase activity
GO174_RS18065	COG1640	4-alpha-glucanotransferase
GO174_RS18070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GO174_RS18080	COG3501	Rhs element vgr protein
GO174_RS18125	COG0471	metal ion transport
GO174_RS18135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO174_RS18140	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GO174_RS18145	COG3033	Beta-eliminating lyase
GO174_RS18155	COG2188	Transcriptional regulator
GO174_RS18160	COG1131	(ABC) transporter
GO174_RS18170	COG0840	transmembrane signaling receptor activity
GO174_RS18185	COG3383	formate dehydrogenase (NAD+) activity
GO174_RS18195	COG0671	phosphoesterase, PA-phosphatase related
GO174_RS18205	COG1132	(ABC) transporter
GO174_RS18225	COG4580	involved in the transport of maltose and maltodextrins
GO174_RS18240	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GO174_RS18245	COG1162	GTPase activity
GO174_RS18255	COG1999	signal sequence binding
GO174_RS18270	COG0786	glutamate:sodium symporter activity
GO174_RS18305	COG1566	PFAM secretion protein HlyD family protein
GO174_RS18315	COG3706	GGDEF domain
GO174_RS18330	COG0813	purine-nucleoside phosphorylase activity
GO174_RS18335	COG3272	Protein of unknown function (DUF1722)
GO174_RS18345	COG0415	Belongs to the DNA photolyase family
GO174_RS18350	COG1388	LysM domain
GO174_RS18350	COG1376	ErfK ybiS ycfS ynhG family protein
GO174_RS18360	COG0513	Belongs to the DEAD box helicase family
GO174_RS18365	COG0840	transmembrane signaling receptor activity
GO174_RS18370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO174_RS18375	COG0573	inorganic phosphate transmembrane transporter activity
GO174_RS18380	COG0581	inorganic phosphate transmembrane transporter activity
GO174_RS18390	COG2199	diguanylate cyclase activity
GO174_RS18405	COG0659	secondary active sulfate transmembrane transporter activity
GO174_RS18420	COG0739	heme binding
GO174_RS18425	COG3300	MHYT domain
GO174_RS18425	COG5001	Diguanylate cyclase
GO174_RS18430	COG0583	DNA-binding transcription factor activity
GO174_RS18435	COG2814	Major facilitator Superfamily
GO174_RS18450	COG0697	spore germination
GO174_RS18455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO174_RS18465	COG0583	DNA-binding transcription factor activity
GO174_RS18470	COG0778	Nitroreductase
GO174_RS18475	COG1342	Belongs to the UPF0251 family
GO174_RS18485	COG0583	DNA-binding transcription factor activity
GO174_RS18490	COG3384	dioxygenase
GO174_RS18495	COG0840	transmembrane signaling receptor activity
GO174_RS18520	COG4774	siderophore transport
GO174_RS18525	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO174_RS18530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO174_RS18535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO174_RS18540	COG1120	ATPase activity
GO174_RS18550	COG0583	DNA-binding transcription factor activity
GO174_RS18555	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS18560	COG3240	lipase activity
GO174_RS18580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GO174_RS18585	COG1349	DNA-binding transcription factor activity
GO174_RS18590	COG0673	inositol 2-dehydrogenase activity
GO174_RS18595	COG4702	Belongs to the UPF0303 family
GO174_RS18605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO174_RS18620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO174_RS18640	COG2814	Major facilitator Superfamily
GO174_RS18645	COG0583	DNA-binding transcription factor activity
GO174_RS18650	COG1902	pentaerythritol trinitrate reductase activity
GO174_RS18655	COG0656	L-ascorbic acid biosynthetic process
GO174_RS18660	COG2200	EAL domain
GO174_RS18670	COG3842	ATPase activity
GO174_RS18700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO174_RS18715	COG2130	NADP-dependent
GO174_RS18720	COG1309	transcriptional regulator
GO174_RS18725	COG0564	pseudouridine synthase activity
GO174_RS18740	COG1846	Transcriptional regulator
GO174_RS18745	COG1280	lysine exporter protein (LysE YggA)
GO174_RS18840	COG3501	Rhs element vgr protein
GO174_RS18855	COG1869	D-ribose catabolic process
GO174_RS18860	COG1129	ABC transporter
GO174_RS18865	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO174_RS18870	COG1879	ABC-type sugar transport system periplasmic component
GO174_RS18875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO174_RS18885	COG0583	DNA-binding transcription factor activity
GO174_RS18890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GO174_RS18895	COG0584	glycerophosphoryl diester phosphodiesterase
GO174_RS18900	COG2271	Major facilitator Superfamily
GO174_RS18905	COG3300	MHYT domain
GO174_RS18905	COG5001	Diguanylate cyclase
GO174_RS18930	COG2188	Transcriptional regulator
GO174_RS18935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS18935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS18935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO174_RS18940	COG0383	alpha-mannosidase activity
GO174_RS18945	COG1929	Belongs to the glycerate kinase type-1 family
GO174_RS18955	COG2204	response regulator
GO174_RS18970	COG0579	oxidoreductase
GO174_RS18980	COG3530	Putative quorum-sensing-regulated virulence factor
GO174_RS18990	COG0589	response to stress
GO174_RS18995	COG3171	Protein conserved in bacteria
GO174_RS19020	COG0583	DNA-binding transcription factor activity
GO174_RS19045	COG4948	Mandelate Racemase Muconate Lactonizing
GO174_RS19070	COG1012	belongs to the aldehyde dehydrogenase family
GO174_RS19075	COG3724	N-succinylarginine dihydrolase activity
GO174_RS19085	COG0745	RESPONSE REGULATOR receiver
GO174_RS19085	COG3706	GGDEF domain
GO174_RS19090	COG0784	Response regulator, receiver
GO174_RS19090	COG2205	protein histidine kinase activity
GO174_RS19090	COG5002	protein histidine kinase activity
GO174_RS19135	COG0714	Associated with various cellular activities
GO174_RS19155	COG0366	Alpha amylase catalytic
GO174_RS19165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO174_RS19170	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO174_RS19180	COG3604	Transcriptional regulator
GO174_RS19185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO174_RS19185	COG1017	nitric oxide dioxygenase activity
GO174_RS19190	COG3706	GGDEF domain
GO174_RS19195	COG4681	YaeQ
GO174_RS19200	COG1278	Cold shock
GO174_RS19205	COG3036	rescue of stalled ribosome
GO174_RS19225	COG0745	RESPONSE REGULATOR receiver
GO174_RS19235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GO174_RS19235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GO174_RS19240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO174_RS19255	COG4974	Belongs to the 'phage' integrase family
GO174_RS19265	COG0798	PFAM Bile acid sodium symporter
GO174_RS19305	COG4964	Belongs to the GSP D family
GO174_RS19365	COG0840	transmembrane signaling receptor activity
GO174_RS19380	COG4533	DNA binding
GO174_RS19385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO174_RS19390	COG3835	regulator
GO174_RS19395	COG2610	gluconate transmembrane transporter activity
GO174_RS19400	COG1929	Belongs to the glycerate kinase type-1 family
GO174_RS19405	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GO174_RS19410	COG1473	amidohydrolase
GO174_RS19425	COG0531	amino acid
GO174_RS19430	COG0646	methionine synthase
GO174_RS19430	COG1410	methionine synthase
GO174_RS19445	COG0583	DNA-binding transcription factor activity
GO174_RS19460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO174_RS19465	COG0363	glucosamine-6-phosphate deaminase activity
GO174_RS19470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GO174_RS19475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO174_RS19485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO174_RS19505	COG0346	lactoylglutathione lyase activity
GO174_RS19515	COG3284	Transcriptional regulator
GO174_RS19520	COG1012	belongs to the aldehyde dehydrogenase family
GO174_RS19525	COG0156	8-amino-7-oxononanoate synthase activity
GO174_RS19530	COG1063	alcohol dehydrogenase
GO174_RS19565	COG0583	DNA-binding transcription factor activity
GO174_RS19570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GO174_RS19580	COG2084	Dehydrogenase
GO174_RS19585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO174_RS19595	COG0242	peptide deformylase activity
GO174_RS19605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO174_RS19615	COG2246	polysaccharide biosynthetic process
GO174_RS19620	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GO174_RS19630	COG1132	(ABC) transporter
GO174_RS19635	COG1132	(ABC) transporter
GO174_RS19665	COG0251	oxidation-reduction process
GO174_RS19680	COG0071	Belongs to the small heat shock protein (HSP20) family
GO174_RS19685	COG3047	cAMP biosynthetic process
GO174_RS19690	COG3227	Zinc metalloprotease (Elastase)
GO174_RS19695	COG0366	Alpha amylase catalytic
GO174_RS19710	COG4989	oxidoreductase activity
GO174_RS19715	COG3275	phosphorelay sensor kinase activity
GO174_RS19720	COG3279	Response regulator of the LytR AlgR family
GO174_RS19725	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO174_RS19745	COG0840	transmembrane signaling receptor activity
GO174_RS19755	COG2814	Major facilitator Superfamily
GO174_RS19775	COG1522	sequence-specific DNA binding
GO174_RS19785	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO174_RS19790	COG5380	lipid catabolic process
GO174_RS19795	COG3291	Pkd domain containing protein
GO174_RS19795	COG4412	M6 family metalloprotease domain protein
GO174_RS19815	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO174_RS19820	COG4605	iron ion homeostasis
GO174_RS19825	COG4604	ABC transporter, ATP-binding protein
GO174_RS19830	COG1609	Transcriptional regulator
GO174_RS19830	COG2207	Transcriptional regulator
GO174_RS19845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO174_RS19885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO174_RS19890	COG1454	alcohol dehydrogenase
GO174_RS19895	COG2207	Transcriptional regulator
GO174_RS19895	COG1609	Transcriptional regulator
GO174_RS19925	COG3634	alkyl hydroperoxide reductase activity
GO174_RS19930	COG0450	alkyl hydroperoxide reductase
GO174_RS19945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO174_RS19950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO174_RS19955	COG1960	acyl-CoA dehydrogenase activity
GO174_RS19965	COG0183	Belongs to the thiolase family
GO174_RS19975	COG1960	acyl-CoA dehydrogenase activity
GO174_RS19980	COG1024	Enoyl-CoA hydratase
GO174_RS19985	COG1024	Enoyl-CoA hydratase
GO174_RS19995	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS20025	COG0653	protein targeting
GO174_RS20040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO174_RS20060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO174_RS20060	COG0512	Glutamine amidotransferase of anthranilate synthase
GO174_RS20065	COG1464	Belongs to the NlpA lipoprotein family
GO174_RS20085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO174_RS20090	COG0573	inorganic phosphate transmembrane transporter activity
GO174_RS20100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO174_RS20120	COG0625	glutathione transferase activity
GO174_RS20175	COG2721	sulfolactate sulfo-lyase activity
GO174_RS20190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO174_RS20200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO174_RS20205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO174_RS20210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO174_RS20230	COG1473	amidohydrolase
GO174_RS20245	COG1280	lysine exporter protein (LysE YggA)
GO174_RS20250	COG0400	carboxylic ester hydrolase activity
GO174_RS20255	COG0435	Glutathione S-transferase
GO174_RS20260	COG0583	DNA-binding transcription factor activity
GO174_RS20265	COG4145	pantothenate transmembrane transporter activity
GO174_RS20275	COG2423	ornithine cyclodeaminase activity
GO174_RS20290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO174_RS20315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GO174_RS20325	COG2198	Histidine kinase
GO174_RS20325	COG0784	Response regulator, receiver
GO174_RS20325	COG2205	protein histidine kinase activity
GO174_RS20330	COG3437	response regulator, receiver
GO174_RS20340	COG4172	Belongs to the ABC transporter superfamily
GO174_RS20345	COG0747	negative chemotaxis
GO174_RS20365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO174_RS20370	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GO174_RS20380	COG3706	GGDEF domain
GO174_RS20385	COG0110	maltose O-acetyltransferase activity
GO174_RS20390	COG1349	DNA-binding transcription factor activity
GO174_RS20400	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GO174_RS20425	COG1538	Outer membrane efflux protein
GO174_RS20450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS20460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS20460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS20460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO174_RS20465	COG2207	Transcriptional regulator
GO174_RS20475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS20480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS20490	COG1252	NADH dehydrogenase
GO174_RS20500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO174_RS20505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO174_RS20510	COG4232	protein-disulfide reductase activity
GO174_RS20520	COG3710	Transcriptional regulator
GO174_RS20535	COG0583	DNA-binding transcription factor activity
GO174_RS20545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO174_RS20555	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GO174_RS20560	COG0513	Belongs to the DEAD box helicase family
GO174_RS20565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO174_RS20605	COG4628	conserved protein (DUF2132)
GO174_RS20670	COG0789	Transcriptional regulator
GO174_RS20675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO174_RS20735	COG0454	-acetyltransferase
GO174_RS20745	COG1028	Short-chain dehydrogenase reductase Sdr
GO174_RS20765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO174_RS20795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO174_RS20805	COG0494	nUDIX hydrolase
GO174_RS20810	COG1280	lysine exporter protein (LysE YggA)
GO174_RS20820	COG0456	acetyltransferase
GO174_RS20825	COG4977	sequence-specific DNA binding
GO174_RS20830	COG1335	isochorismatase
GO174_RS20860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO174_RS20865	COG1309	transcriptional regulator
GO174_RS20880	COG0583	DNA-binding transcription factor activity
GO174_RS20890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO174_RS20900	COG0745	RESPONSE REGULATOR receiver
GO174_RS20905	COG1280	lysine exporter protein (LysE YggA)
GO174_RS20960	COG1328	CTP reductase activity
GO174_RS20965	COG0602	queuosine metabolic process
GO174_RS20975	COG0189	ligase activity
GO174_RS20975	COG4067	protein conserved in archaea
GO174_RS20980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GO174_RS20980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS20980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO174_RS20985	COG1105	Belongs to the carbohydrate kinase PfkB family
GO174_RS20990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO174_RS20990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO174_RS20995	COG1609	Transcriptional regulator
GO174_RS21005	COG0419	ATPase involved in DNA repair
GO174_RS21010	COG0784	Response regulator, receiver
GO174_RS21010	COG2205	protein histidine kinase activity
GO174_RS21015	COG0156	8-amino-7-oxononanoate synthase activity
GO174_RS21025	COG0038	chloride channel
GO174_RS21030	COG0523	cobalamin synthesis protein
GO174_RS21050	COG3501	Rhs element vgr protein
GO174_RS21085	COG0328	RNA-DNA hybrid ribonuclease activity
GO174_RS21120	COG2003	Belongs to the UPF0758 family
GO174_RS21135	COG1518	maintenance of DNA repeat elements
GO174_RS21185	COG3290	protein histidine kinase activity
GO174_RS21185	COG0840	transmembrane signaling receptor activity
GO174_RS21190	COG2239	Acts as a magnesium transporter
GO174_RS21195	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GO174_RS21200	COG2197	response regulator
GO174_RS21205	COG3850	Histidine kinase
GO174_RS21210	COG2223	nitrite transmembrane transporter activity
GO174_RS21215	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GO174_RS21240	COG2181	nitrate reductase activity
GO174_RS21275	COG5001	Diguanylate cyclase
GO174_RS21275	COG3706	GGDEF domain
GO174_RS21275	COG2203	Gaf domain
GO174_RS21275	COG4251	negative regulation of phosphorylation
GO174_RS21290	COG2200	EAL domain
GO174_RS21290	COG2202	Pas domain
GO174_RS21290	COG2199	diguanylate cyclase activity
GO174_RS21295	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO174_RS21315	COG0582	viral genome integration into host DNA
GO174_RS21320	COG2207	Transcriptional regulator
GO174_RS21330	COG3437	response regulator, receiver
GO174_RS21340	COG3217	Mosc domain protein beta barrel domain protein
GO174_RS21340	COG0633	Ferredoxin
GO174_RS21345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO174_RS21350	COG0243	molybdopterin cofactor binding
GO174_RS21360	COG5001	Diguanylate cyclase
GO174_RS21385	COG3038	cytochrome b561
GO174_RS21390	COG2353	YceI-like domain
GO174_RS21395	COG2116	formate transmembrane transporter activity
GO174_RS21400	COG0583	DNA-binding transcription factor activity
GO174_RS21410	COG3593	DNA synthesis involved in DNA repair
GO174_RS21415	COG0737	Belongs to the 5'-nucleotidase family
GO174_RS21420	COG0861	Integral membrane protein TerC family
GO174_RS21430	COG2824	Alkylphosphonate utilization operon protein PhnA
GO174_RS21435	COG0501	Belongs to the peptidase M48B family
GO174_RS21440	COG2050	protein possibly involved in aromatic compounds catabolism
GO174_RS21460	COG4771	TonB-dependent receptor
GO174_RS21460	COG1629	transport
GO174_RS21465	COG0583	DNA-binding transcription factor activity
GO174_RS21470	COG1042	CoA-binding domain protein
GO174_RS21470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO174_RS21470	COG0045	succinate-CoA ligase (ADP-forming) activity
GO174_RS21480	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO174_RS21495	COG0023	Translation Initiation Factor
GO174_RS21580	COG0745	RESPONSE REGULATOR receiver
GO174_RS21590	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GO174_RS21595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GO174_RS21610	COG0745	RESPONSE REGULATOR receiver
GO174_RS21610	COG3706	GGDEF domain
GO174_RS21620	COG3706	GGDEF domain
GO174_RS21630	COG1309	transcriptional regulator
GO174_RS21635	COG1129	ABC transporter
GO174_RS21675	COG2351	hydroxyisourate hydrolase activity
GO174_RS21680	COG0402	S-adenosylhomocysteine deaminase activity
GO174_RS21700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO174_RS21730	COG0765	amino acid transport
GO174_RS21735	COG0765	amino acid transport
GO174_RS21745	COG1953	Uracil, thiamine, allantoin
GO174_RS21765	COG2233	PERMEase
GO174_RS21780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO174_RS21810	COG3710	Transcriptional regulator
GO174_RS21830	COG2814	Major facilitator Superfamily
GO174_RS21850	COG0488	(ABC) transporter
GO174_RS21860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GO174_RS21880	COG2207	Transcriptional regulator
GO174_RS21885	COG1979	alcohol dehydrogenase
GO174_RS21910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO174_RS21950	COG2501	S4 domain
GO174_RS21960	COG3706	GGDEF domain
GO174_RS21975	COG0784	Response regulator, receiver
GO174_RS21975	COG2205	protein histidine kinase activity
GO174_RS21995	COG4172	Belongs to the ABC transporter superfamily
GO174_RS22000	COG4239	(ABC) transporter, permease
GO174_RS22005	COG4174	ABC transporter (Permease)
GO174_RS22010	COG4166	transmembrane transport
GO174_RS22035	COG2866	Carboxypeptidase
GO174_RS22055	COG3842	ATPase activity
GO174_RS22065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO174_RS22085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO174_RS22090	COG1011	Hydrolase
GO174_RS22100	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GO174_RS22105	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GO174_RS22110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO174_RS22110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO174_RS22115	COG2207	Transcriptional regulator
GO174_RS22120	COG4303	Ethanolamine ammonia lyase large subunit
GO174_RS22130	COG0531	amino acid
GO174_RS22135	COG0302	gtp cyclohydrolase
GO174_RS22145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO174_RS22150	COG2897	thiosulfate sulfurtransferase activity
GO174_RS22165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO174_RS22170	COG0840	transmembrane signaling receptor activity
GO174_RS22185	COG0545	Peptidyl-prolyl cis-trans isomerase
GO174_RS22190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO174_RS22195	COG0840	transmembrane signaling receptor activity
GO174_RS22200	COG2814	Major facilitator Superfamily
GO174_RS22215	COG3069	C4-dicarboxylate transmembrane transporter activity
GO174_RS22220	COG2197	response regulator
GO174_RS22225	COG3850	Histidine kinase
GO174_RS22240	COG0243	molybdopterin cofactor binding
GO174_RS22280	COG0183	Belongs to the thiolase family
GO174_RS22290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO174_RS22295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO174_RS22315	COG3706	GGDEF domain
GO174_RS22320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO174_RS22335	COG2207	Transcriptional regulator
GO174_RS22340	COG1979	alcohol dehydrogenase
GO174_RS22360	COG1840	ABC-type Fe3 transport system, periplasmic component
GO174_RS22365	COG2271	Major facilitator Superfamily
GO174_RS22375	COG0784	Response regulator, receiver
GO174_RS22375	COG2198	Histidine kinase
GO174_RS22375	COG2205	protein histidine kinase activity
GO174_RS22380	COG1879	ABC-type sugar transport system periplasmic component
GO174_RS22385	COG1803	Methylglyoxal synthase
GO174_RS22390	COG1335	isochorismatase
GO174_RS22395	COG0210	DNA helicase