locus-tag	class	description
HPK20_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HPK20_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPK20_RS00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPK20_RS00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPK20_RS00025	ENOG4108ZNX	Heat shock protein
HPK20_RS00030	ENOG4105JKW	Valine--pyruvate aminotransferase
HPK20_RS00035	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HPK20_RS00040	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HPK20_RS00070	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HPK20_RS00075	ENOG4105C7B	Threonine dehydratase
HPK20_RS00080	ENOG4105C01	Dihydroxy-acid dehydratase
HPK20_RS00085	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HPK20_RS00090	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
HPK20_RS00100	ENOG4105C0P	Mg chelatase subunit ChlI
HPK20_RS00120	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPK20_RS00145	ENOG4106HNH	Acyl-transferase
HPK20_RS00150	ENOG4108Z33	Thiol disulfide Interchange Protein
HPK20_RS00155	ENOG4105E27	serine threonine protein kinase
HPK20_RS00165	ENOG4105PC1	Conserved Protein
HPK20_RS00170	ENOG4108N23	SpoOM-related protein
HPK20_RS00175	ENOG4108UT2	hemolysin iii
HPK20_RS00185	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPK20_RS00190	ENOG4105C1A	potassium transporter peripheral membrane
HPK20_RS00195	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HPK20_RS00210	ENOG4108WZM	domain protein
HPK20_RS00215	ENOG4105C79	DNA protecting protein DprA
HPK20_RS00220	ENOG4108RPN	Protein smg homolog
HPK20_RS00225	ENOG4108WI1	Dna topoisomerase
HPK20_RS00230	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HPK20_RS00240	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPK20_RS00245	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HPK20_RS00250	ENOG4105E2X	shikimate dehydrogenase
HPK20_RS00255	ENOG4105SG3	Protein of unknown function (DUF1488)
HPK20_RS00260	ENOG4108Z0R	Transferase
HPK20_RS00300	ENOG4105EMY	transcriptional regulator
HPK20_RS00310	ENOG4105W0Z	cytoplasmic protein
HPK20_RS00315	ENOG4105BZS	acriflavin resistance protein
HPK20_RS00320	ENOG410624X	efflux transporter, rnd family, mfp subunit
HPK20_RS00325	ENOG41067SE	Tetr family transcriptional regulator
HPK20_RS00330	ENOG4105C4R	Atp-dependent dna helicase
HPK20_RS00335	ENOG4105MPD	Cytochrome
HPK20_RS00365	ENOG4108JQ6	ABC transporter
HPK20_RS00370	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPK20_RS00375	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS00380	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS00390	ENOG4105BZS	acriflavin resistance protein
HPK20_RS00395	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HPK20_RS00410	ENOG4105DC8	reductase
HPK20_RS00415	ENOG4105D6S	protein involved in catabolism of external DNA
HPK20_RS00420	ENOG4105DGW	oligopeptidase A
HPK20_RS00440	ENOG4105E18	UPF0276 protein
HPK20_RS00450	ENOG4105C4R	Atp-dependent dna helicase
HPK20_RS00455	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPK20_RS00460	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPK20_RS00470	ENOG4105FR1	rard protein
HPK20_RS00475	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPK20_RS00490	ENOG4105BZ1	(ABC) transporter
HPK20_RS00495	ENOG4105E0A	ABC, transporter
HPK20_RS00500	ENOG4108HUF	Transporter
HPK20_RS00505	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
HPK20_RS00515	ENOG4108TEB	UPF0114 protein
HPK20_RS00520	ENOG4105DSJ	YicC domain protein
HPK20_RS00525	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HPK20_RS00530	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPK20_RS00535	ENOG4105D1S	lipid A biosynthesis
HPK20_RS00540	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HPK20_RS00545	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HPK20_RS00550	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS00555	ENOG4105W5Q	DNA repair protein (RadC
HPK20_RS00560	ENOG4105KDC	50s ribosomal protein l28
HPK20_RS00565	ENOG4105W0E	50S ribosomal protein L33
HPK20_RS00575	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HPK20_RS00590	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HPK20_RS00595	ENOG4108PQP	glycosyl transferase group 1
HPK20_RS00600	ENOG4105CPK	Glycosyl transferase (Group 1
HPK20_RS00605	ENOG4106WTF	Glycosyl transferase, family 2
HPK20_RS00610	ENOG4105DKP	glycosyl transferase, family 9
HPK20_RS00620	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HPK20_RS00625	ENOG4105XA0	heptosyltransferase ii
HPK20_RS00640	ENOG4107RA4	Glycosyl transferase (Group 1
HPK20_RS00655	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
HPK20_RS00665	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HPK20_RS00670	ENOG4105E3R	(LipO)protein
HPK20_RS00680	ENOG4108Y9B	(LipO)protein
HPK20_RS00690	ENOG4105DAY	polysaccharide export protein
HPK20_RS00700	ENOG4105D75	Capsular exopolysaccharide family
HPK20_RS00705	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPK20_RS00710	ENOG4108IJ1	Dehydrogenase
HPK20_RS00755	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HPK20_RS00765	ENOG4107R08	Integrase
HPK20_RS00805	ENOG4105EIP	mannose-6-phosphate isomerase
HPK20_RS00810	ENOG4105CXY	transporter
HPK20_RS00815	ENOG4105BZU	Histidine kinase
HPK20_RS00820	ENOG4108KX4	response regulator
HPK20_RS00825	ENOG4105CXY	transporter
HPK20_RS00835	ENOG4105C2J	ABC transporter
HPK20_RS00840	ENOG4105CNN	ABC, transporter
HPK20_RS00845	ENOG4105F5R	ABC transporter
HPK20_RS00850	ENOG4105CMG	Carbohydrate kinase
HPK20_RS00885	ENOG4105ESV	Glycosyl transferase, family 4
HPK20_RS00910	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPK20_RS00920	ENOG4105PNM	synthesis protein
HPK20_RS00930	ENOG4105CG5	Glycosyl transferase (Group 1
HPK20_RS00935	ENOG4107TAE	Glycosyl transferase (Group 1
HPK20_RS00950	ENOG4105CY0	Metallo-Beta-Lactamase
HPK20_RS00955	ENOG4108RG0	uracil-dna glycosylase
HPK20_RS00960	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_RS00965	ENOG4105R2J	Conserved Protein
HPK20_RS00970	ENOG4105CUY	Mechanosensitive ion channel
HPK20_RS00980	ENOG4105K70	DNA-binding protein
HPK20_RS00995	ENOG4105C12	Phosphoribosylglycinamide synthetase
HPK20_RS01000	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HPK20_RS01010	ENOG4105W1Y	Transcriptional regulator
HPK20_RS01015	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS01020	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HPK20_RS01025	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPK20_RS01030	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPK20_RS01035	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HPK20_RS01040	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HPK20_RS01045	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HPK20_RS01065	ENOG4105D8G	Major Facilitator superfamily
HPK20_RS01070	ENOG4105BZU	Histidine kinase
HPK20_RS01075	ENOG4105C9X	ppx gppa phosphatase
HPK20_RS01080	ENOG4105C1J	atp-dependent rna helicase
HPK20_RS01090	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HPK20_RS01100	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HPK20_RS01110	ENOG4107QK7	reductase
HPK20_RS01165	ENOG4105JIM	Phosphatidylserine synthase
HPK20_RS01175	ENOG4105D4A	Cell wall formation (By similarity)
HPK20_RS01180	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HPK20_RS01185	ENOG4105CS9	pantothenic acid kinase
HPK20_RS01215	ENOG4105PM1	preprotein translocase subunit SecE
HPK20_RS01220	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HPK20_RS01235	ENOG4108VZM	50s ribosomal protein L10
HPK20_RS01245	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPK20_RS01250	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPK20_RS01255	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HPK20_RS01260	ENOG4105E09	nadh pyrophosphatase
HPK20_RS01270	ENOG41062JF	Transcriptional regulator
HPK20_RS01280	ENOG41063SB	peptidase
HPK20_RS01285	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HPK20_RS01295	ENOG4108NVR	Methyl-accepting chemotaxis
HPK20_RS01300	ENOG4107QWE	)-transporter
HPK20_RS01305	ENOG4105DJ4	phosphatidylserine decarboxylase
HPK20_RS01310	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPK20_RS01315	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HPK20_RS01365	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HPK20_RS01370	ENOG4105K8N	protein family UPF0079, ATPase
HPK20_RS01375	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HPK20_RS01380	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HPK20_RS01385	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HPK20_RS01390	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HPK20_RS01395	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HPK20_RS01400	ENOG4107QJR	hflk protein
HPK20_RS01405	ENOG4105EPW	hflc protein
HPK20_RS01415	ENOG41069P5	Protein slyX homolog
HPK20_RS01425	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPK20_RS01430	ENOG4105WWK	YheO domain protein
HPK20_RS01440	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HPK20_RS01445	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HPK20_RS01450	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HPK20_RS01455	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HPK20_RS01470	ENOG4105W53	bacterioferritin-associated ferredoxin
HPK20_RS01475	ENOG4108UQY	Iron-storage protein
HPK20_RS01480	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HPK20_RS01485	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
HPK20_RS01490	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HPK20_RS01495	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HPK20_RS01505	ENOG4105CDU	Replicative dna helicase
HPK20_RS01510	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPK20_RS01515	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HPK20_RS01520	ENOG4107QP8	phosphohexose isomerase
HPK20_RS01530	ENOG4105MYN	Zinc uptake regulation protein
HPK20_RS01535	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPK20_RS01555	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HPK20_RS01560	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HPK20_RS01565	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HPK20_RS01630	ENOG4105EEQ	Na H antiporter
HPK20_RS01635	ENOG4105C3R	Methionine synthase
HPK20_RS01640	ENOG4105CFH	Aspartokinase
HPK20_RS01645	ENOG4105C5R	Aminotransferase
HPK20_RS01660	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HPK20_RS01665	ENOG41086KC	Transcriptional regulator
HPK20_RS01670	ENOG4108UUM	single-stranded DNA-binding protein
HPK20_RS01675	ENOG41062P1	Diguanylate cyclase phosphodiesterase
HPK20_RS01710	ENOG4107QHF	type ii secretion system protein e
HPK20_RS01730	ENOG4108VAU	general secretion pathway protein G
HPK20_RS01765	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HPK20_RS01770	ENOG4105VQ7	Rod shape-determining protein MreD
HPK20_RS01775	ENOG4108Z03	MAF-like protein
HPK20_RS01780	ENOG4105C03	ribonuclease
HPK20_RS01785	ENOG4105QD6	exported protein
HPK20_RS01795	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HPK20_RS01815	ENOG41081QV	Universal stress protein
HPK20_RS01830	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HPK20_RS01840	ENOG4105D5Q	Arginine ornithine antiporter
HPK20_RS01845	ENOG4105EAH	synthase
HPK20_RS01850	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HPK20_RS01860	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPK20_RS01865	ENOG4105DWK	Membrane
HPK20_RS01870	ENOG4107XM3	UPF0442 protein
HPK20_RS01880	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HPK20_RS01885	ENOG4105NWN	ApaG protein
HPK20_RS01900	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HPK20_RS01905	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HPK20_RS01910	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HPK20_RS01940	ENOG4107SDU	Methyl-accepting chemotaxis
HPK20_RS01965	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HPK20_RS01970	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HPK20_RS01975	ENOG4105CEN	a g-specific adenine glycosylase
HPK20_RS01985	ENOG4105CSV	Glutaminase
HPK20_RS01995	ENOG4105CSA	Coproporphyrinogen iii oxidase
HPK20_RS02010	ENOG4105VZ9	UPF0235 protein
HPK20_RS02015	ENOG4108VIA	integral membrane protein
HPK20_RS02020	ENOG4105II7	pyrroline-5-carboxylate reductase
HPK20_RS02025	ENOG4105DFA	alanine racemase domain protein
HPK20_RS02030	ENOG4105CZX	twitching motility protein
HPK20_RS02035	ENOG4105CZX	twitching motility protein
HPK20_RS02040	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HPK20_RS02045	ENOG4108UJU	UPF0301 protein
HPK20_RS02050	ENOG4105D7Z	glutathione synthase
HPK20_RS02055	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HPK20_RS02060	ENOG4105RWS	endonuclease I
HPK20_RS02065	ENOG4105GPY	SprT protein
HPK20_RS02080	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPK20_RS02085	ENOG4108R4R	Iron-regulated virulence regulatory protein
HPK20_RS02090	ENOG4105D05	Receptor
HPK20_RS02100	ENOG4105BZA	Phosphoglycerate kinase
HPK20_RS02105	ENOG4105D2N	Aldolase
HPK20_RS02110	ENOG4105D64	Mechanosensitive ion channel
HPK20_RS02120	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HPK20_RS02125	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
HPK20_RS02135	ENOG4105BZU	Histidine kinase
HPK20_RS02140	ENOG4105CA9	Pyruvate kinase
HPK20_RS02145	ENOG410804X	Transcriptional regulator
HPK20_RS02150	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HPK20_RS02155	ENOG4105CH5	extracellular solute-binding protein, family 7
HPK20_RS02170	ENOG4105CJW	magnesium transporter
HPK20_RS02190	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPK20_RS02195	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HPK20_RS02200	ENOG4105KTH	gatB Yqey
HPK20_RS02205	ENOG4105VCC	30S ribosomal protein S21
HPK20_RS02210	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPK20_RS02215	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HPK20_RS02220	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HPK20_RS02225	ENOG4107ZVW	dihydroneopterin aldolase
HPK20_RS02230	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPK20_RS02235	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HPK20_RS02240	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HPK20_RS02245	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HPK20_RS02250	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HPK20_RS02255	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HPK20_RS02260	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HPK20_RS02265	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HPK20_RS02270	ENOG4108K5P	(LipO)protein
HPK20_RS02275	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPK20_RS02280	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HPK20_RS02285	ENOG4107TH8	cina domain protein
HPK20_RS02290	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HPK20_RS02295	ENOG4105Y3E	Modulates RecA activity (By similarity)
HPK20_RS02300	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPK20_RS02305	ENOG4105CFH	Aspartokinase
HPK20_RS02310	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HPK20_RS02360	ENOG4107QSA	Oxaloacetate decarboxylase
HPK20_RS02365	ENOG4105D9Q	decarboxylase (Beta subunit)
HPK20_RS02370	ENOG4105CPQ	Dehydrogenase
HPK20_RS02375	ENOG4105W39	Membrane
HPK20_RS02385	ENOG4105D9M	gamma-glutamylcysteine synthetase
HPK20_RS02395	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HPK20_RS02400	ENOG4108JU6	CBS domain protein
HPK20_RS02405	ENOG4106KVJ	cytochrome C assembly protein
HPK20_RS02410	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPK20_RS02415	ENOG4105K5M	30s ribosomal protein S16
HPK20_RS02420	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HPK20_RS02425	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HPK20_RS02430	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HPK20_RS02435	ENOG4105C0H	protease
HPK20_RS02440	ENOG4105C0H	protease
HPK20_RS02445	ENOG4108W2Q	Cytochrome d ubiquinol oxidase subunit III
HPK20_RS02450	ENOG4105D6Z	AFG1 family ATPase
HPK20_RS02455	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HPK20_RS02460	ENOG4108UJD	30S ribosomal protein S9
HPK20_RS02465	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPK20_RS02470	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPK20_RS02475	ENOG4105EIX	cytochrome c1
HPK20_RS02480	ENOG4107MKT	Stringent starvation protein a
HPK20_RS02485	ENOG4105KB2	stringent starvation protein b
HPK20_RS02490	ENOG4105W4M	Transport-associated protein
HPK20_RS02495	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPK20_RS02500	ENOG41082RQ	UPF0102 protein
HPK20_RS02505	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HPK20_RS02510	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HPK20_RS02525	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HPK20_RS02530	ENOG4105CJN	penicillin-binding protein
HPK20_RS02535	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HPK20_RS02540	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HPK20_RS02550	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HPK20_RS02560	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HPK20_RS02565	ENOG4105DFU	Cell wall formation (By similarity)
HPK20_RS02570	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HPK20_RS02575	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HPK20_RS02580	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HPK20_RS02585	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPK20_RS02595	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPK20_RS02600	ENOG4105M6F	mutator MutT protein
HPK20_RS02605	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HPK20_RS02610	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HPK20_RS02620	ENOG4105EJ9	Membrane
HPK20_RS02625	ENOG4105VP0	transcriptional regulator, lysR family
HPK20_RS02645	ENOG4105EN6	Membrane
HPK20_RS02650	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HPK20_RS02660	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HPK20_RS02670	ENOG4105BZ8	glutamate synthase
HPK20_RS02675	ENOG4105CBC	glutamate synthase
HPK20_RS02690	ENOG4105N5T	Radical SAM Protein
HPK20_RS02700	ENOG4105BZU	Histidine kinase
HPK20_RS02710	ENOG41065U4	response regulator
HPK20_RS02720	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPK20_RS02735	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HPK20_RS02740	ENOG4105D98	threonine synthase
HPK20_RS02750	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HPK20_RS02760	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HPK20_RS02775	ENOG4105BZG	amino acid carrier protein
HPK20_RS02780	ENOG4105D1Q	UPF0246 protein
HPK20_RS02790	ENOG4105EYA	deoxyribonuclease
HPK20_RS02800	ENOG4105UIB	(ABC) transporter
HPK20_RS02805	ENOG4108JQ9	ABC transporter
HPK20_RS02810	ENOG4105DIH	basic membrane
HPK20_RS02815	ENOG4105D9N	nucleoside
HPK20_RS02820	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HPK20_RS02825	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HPK20_RS02830	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HPK20_RS02835	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPK20_RS02845	ENOG4105EAC	phosphoserine phosphatase
HPK20_RS02855	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HPK20_RS02865	ENOG4105ETT	transcriptional Regulator, LysR family
HPK20_RS02875	ENOG4105ETT	transcriptional Regulator, LysR family
HPK20_RS02965	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPK20_RS02970	ENOG4105FGV	Chromate
HPK20_RS02975	ENOG410838F	Glycosyl transferase family 2
HPK20_RS02985	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HPK20_RS02990	ENOG4108Y51	tRNA-binding protein
HPK20_RS03005	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPK20_RS03010	ENOG4108R6G	acetyltransferase
HPK20_RS03020	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HPK20_RS03025	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HPK20_RS03030	ENOG4105X2V	dna damage-inducible protein
HPK20_RS03035	ENOG4106P55	Transcriptional regulator
HPK20_RS03045	ENOG4105DSY	exodeoxyribonuclease V, gamma
HPK20_RS03050	ENOG4107QKA	exodeoxyribonuclease V beta
HPK20_RS03055	ENOG4107QYX	exodeoxyribonuclease v alpha
HPK20_RS03065	ENOG4107QZM	n-acetylglutamate synthase
HPK20_RS03075	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HPK20_RS03080	ENOG4105CUZ	uba thif-type nad fad binding protein
HPK20_RS03085	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HPK20_RS03095	ENOG4105C9B	Cysteine desulfurase
HPK20_RS03100	ENOG4107S0N	DJ-1 family
HPK20_RS03105	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HPK20_RS03110	ENOG4105DRB	nucleoside-specific channel-forming protein
HPK20_RS03120	ENOG4105K6V	RNA polymerase
HPK20_RS03130	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPK20_RS03135	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HPK20_RS03140	ENOG4105CFP	Peptidase U32
HPK20_RS03150	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPK20_RS03155	ENOG4105BZU	Histidine kinase
HPK20_RS03160	ENOG4105DJH	phosphate
HPK20_RS03170	ENOG4105C9X	ppx gppa phosphatase
HPK20_RS03175	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HPK20_RS03180	ENOG4105C8U	phosphate abc transporter
HPK20_RS03185	ENOG4105E2Z	phosphate ABC transporter (Permease
HPK20_RS03190	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS03200	ENOG4105CSR	polyphosphate kinase 2
HPK20_RS03205	ENOG4106N3A	copper homeostasis protein cutc
HPK20_RS03210	ENOG4105D3R	alkyl hydroperoxide reductase
HPK20_RS03215	ENOG4105C5Q	Transcriptional regulator
HPK20_RS03220	ENOG4107QP3	malate synthase g
HPK20_RS03225	ENOG4108I9X	Isocitrate lyase
HPK20_RS03230	ENOG4105W87	Cbs domain
HPK20_RS03235	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HPK20_RS03245	ENOG4105VIE	preprotein translocase, subunit YajC
HPK20_RS03250	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPK20_RS03255	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPK20_RS03260	ENOG4105D3W	isochorismatase
HPK20_RS03265	ENOG4105ECY	inositol monophosphatase
HPK20_RS03270	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HPK20_RS03275	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HPK20_RS03280	ENOG4105C3J	Cysteine desulfurase
HPK20_RS03285	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HPK20_RS03290	ENOG4108Z4V	iron-sulfur cluster assembly
HPK20_RS03295	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HPK20_RS03300	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPK20_RS03305	ENOG4108ZIT	Ferredoxin, 2FE-2S
HPK20_RS03310	ENOG4105WVQ	Fe-S assembly protein IscX
HPK20_RS03315	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPK20_RS03330	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
HPK20_RS03335	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HPK20_RS03340	ENOG4105CUT	histidyl-tRNA synthetase
HPK20_RS03345	ENOG4105N21	Membrane
HPK20_RS03350	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPK20_RS03355	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPK20_RS03370	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPK20_RS03375	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPK20_RS03380	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPK20_RS03385	ENOG4105DFP	Integrase
HPK20_RS03470	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HPK20_RS03475	ENOG4105C09	Bile acid
HPK20_RS03480	ENOG4105CSH	Transporter
HPK20_RS03485	ENOG4105CH2	amidohydrolase
HPK20_RS03495	ENOG4105BZG	amino acid carrier protein
HPK20_RS03605	ENOG4105C4R	Atp-dependent dna helicase
HPK20_RS03630	ENOG4105DVF	Cytosine-specific methyltransferase
HPK20_RS03645	ENOG4105DFP	Integrase
HPK20_RS03655	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HPK20_RS03660	ENOG4108Z1B	Cyclase dehydrase
HPK20_RS03665	ENOG4105VDB	UPF0125 protein
HPK20_RS03670	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPK20_RS03675	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HPK20_RS03680	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HPK20_RS03695	ENOG4105CFG	Acts as a chaperone (By similarity)
HPK20_RS03705	ENOG4108ZUW	Major pilin subunit
HPK20_RS03730	ENOG4105CFC	Transporter
HPK20_RS03740	ENOG4107QPD	alcohol dehydrogenase
HPK20_RS03745	ENOG4105CC0	LysR family Transcriptional regulator
HPK20_RS03750	ENOG4108Z6B	deaminase
HPK20_RS03755	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HPK20_RS03760	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HPK20_RS03780	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HPK20_RS03785	ENOG4108R96	Methyltransferase, YaeB family
HPK20_RS03800	ENOG4105CFC	Transporter
HPK20_RS03805	ENOG4108UPT	UPF0178 protein
HPK20_RS03830	ENOG4105WP7	tRNA pseudouridine synthase C
HPK20_RS03835	ENOG4105DR9	pseudouridine synthase
HPK20_RS03840	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HPK20_RS03845	ENOG4105CTB	Polyprenyl synthetase
HPK20_RS03855	ENOG4105E14	MotA TolQ exbB proton channel
HPK20_RS03860	ENOG4106VK6	Flagellar motor protein
HPK20_RS03865	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HPK20_RS03870	ENOG4105ETT	transcriptional Regulator, LysR family
HPK20_RS03880	ENOG4105M08	Membrane
HPK20_RS03885	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
HPK20_RS03890	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HPK20_RS03895	ENOG4105EWT	decarboxylase family
HPK20_RS03910	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HPK20_RS03915	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HPK20_RS03920	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HPK20_RS03925	ENOG4105D01	(LipO)protein
HPK20_RS03930	ENOG4108UMI	ABC transporter, permease
HPK20_RS03940	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HPK20_RS03950	ENOG4105D4X	repressor
HPK20_RS03955	ENOG4105C5Y	PTS System
HPK20_RS03960	ENOG4105CG3	alpha amylase, catalytic region
HPK20_RS03985	ENOG410624X	efflux transporter, rnd family, mfp subunit
HPK20_RS03990	ENOG4105BZS	acriflavin resistance protein
HPK20_RS04010	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HPK20_RS04020	ENOG4108Z43	UPF0250 protein
HPK20_RS04025	ENOG4105DZ1	carboxypeptidase
HPK20_RS04030	ENOG4105K6T	rare lipoprotein A
HPK20_RS04035	ENOG4105CNI	cell division protein FtsW
HPK20_RS04040	ENOG4105CJN	penicillin-binding protein
HPK20_RS04045	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HPK20_RS04050	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HPK20_RS04055	ENOG4105DJF	DNA polymerase III, delta' subunit
HPK20_RS04060	ENOG4108U2H	Rare lipoprotein B
HPK20_RS04065	ENOG4105C8T	Leucyl-tRNA synthetase
HPK20_RS04070	ENOG4107PAI	alpha helical protein
HPK20_RS04075	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HPK20_RS04080	ENOG4108JU5	Magnesium and cobalt efflux protein
HPK20_RS04085	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HPK20_RS04090	ENOG4105C9A	Phoh family
HPK20_RS04100	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPK20_RS04105	ENOG4105C5Y	PTS System
HPK20_RS04110	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HPK20_RS04115	ENOG4105KZ7	phosphocarrier protein hpr
HPK20_RS04120	ENOG4105C6T	cysteine synthase
HPK20_RS04125	ENOG4105EXN	Sulfate transport protein CysZ
HPK20_RS04130	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
HPK20_RS04135	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HPK20_RS04140	ENOG41081QG	Porin Gram-negative type
HPK20_RS04150	ENOG4108Z6Z	Transcriptional regulator
HPK20_RS04160	ENOG4107QX8	SPFH domain, Band 7 family protein
HPK20_RS04165	ENOG4107QR8	Thioredoxin
HPK20_RS04170	ENOG4105E1F	short-chain dehydrogenase reductase
HPK20_RS04175	ENOG4105ECP	epimerase
HPK20_RS04200	ENOG4108RE9	Phosphodiesterase
HPK20_RS04215	ENOG4108DQ1	activator toxR
HPK20_RS04220	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HPK20_RS04225	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HPK20_RS04230	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPK20_RS04235	ENOG4105DUX	Transporter
HPK20_RS04240	ENOG4105MDZ	Transcriptional activator rfaH
HPK20_RS04245	ENOG4105CAQ	asparagine synthetase
HPK20_RS04250	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HPK20_RS04255	ENOG4105E2R	ROK family
HPK20_RS04260	ENOG4105CE4	GlcNAc 6-P deacetylase
HPK20_RS04265	ENOG4105CI1	PTS System
HPK20_RS04280	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HPK20_RS04290	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HPK20_RS04295	ENOG4108S3P	Sporulation domain protein
HPK20_RS04300	ENOG4105E96	Colicin v production protein
HPK20_RS04305	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HPK20_RS04310	ENOG4105D3Y	Na H antiporter
HPK20_RS04315	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HPK20_RS04320	ENOG4105EIY	sodium-type flagellar protein motY
HPK20_RS04325	ENOG4106WH9	Protein of unknown function (DUF2753)
HPK20_RS04330	ENOG4108UYE	Lactoylglutathione lyase
HPK20_RS04335	ENOG4105CSM	endonuclease III
HPK20_RS04340	ENOG4105DZB	Electron transport complex
HPK20_RS04345	ENOG4108UQQ	Electron transport complex
HPK20_RS04350	ENOG4105D6A	Electron transport complex
HPK20_RS04360	ENOG4108R3D	Electron transport complex
HPK20_RS04370	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HPK20_RS04390	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPK20_RS04400	ENOG4105CHW	UPF0052 protein
HPK20_RS04405	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPK20_RS04410	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HPK20_RS04420	ENOG4105M00	molybdopterin converting factor, subunit 1
HPK20_RS04425	ENOG4108ZAF	Molybdopterin
HPK20_RS04430	ENOG4105BZU	Histidine kinase
HPK20_RS04445	ENOG4108I5U	Uridine phosphorylase
HPK20_RS04460	ENOG4105D1F	ATP-binding protein
HPK20_RS04465	ENOG4105DBI	uridine monophosphokinase
HPK20_RS04470	ENOG4108GAE	asmA family
HPK20_RS04475	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HPK20_RS04480	ENOG4107SDU	Methyl-accepting chemotaxis
HPK20_RS04495	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPK20_RS04500	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPK20_RS04515	ENOG4105CHU	acetyl-coa acetyltransferase
HPK20_RS04520	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPK20_RS04525	ENOG41069NU	Nitroreductase
HPK20_RS04530	ENOG4105EJC	lysr family transcriptional regulator
HPK20_RS04535	ENOG4105I93	response regulator
HPK20_RS04540	ENOG4105WD1	Membrane
HPK20_RS04545	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HPK20_RS04550	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HPK20_RS04555	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HPK20_RS04560	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HPK20_RS04565	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPK20_RS04570	ENOG4105KRS	Proteinase inhibitor
HPK20_RS04575	ENOG4108ZZ3	UPF0260 protein
HPK20_RS04595	ENOG4105DHI	Methyltransferase
HPK20_RS04600	ENOG4105DSB	aldose 1-epimerase
HPK20_RS04605	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPK20_RS04610	ENOG4105E0X	reductase
HPK20_RS04620	ENOG4105VUT	cytoplasmic protein
HPK20_RS04625	ENOG4105HDK	L-asparaginase
HPK20_RS04630	ENOG4105D07	Signal peptide peptidase, SppA
HPK20_RS04635	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPK20_RS04640	ENOG4105CIY	formyltetrahydrofolate deformylase
HPK20_RS04650	ENOG4105DVT	helicase
HPK20_RS04655	ENOG41072GX	Peptidase M22 Glycoprotease
HPK20_RS04675	ENOG4105CEY	Amp-dependent synthetase and ligase
HPK20_RS04680	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HPK20_RS04690	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HPK20_RS04695	ENOG4107QMS	site-determining protein
HPK20_RS04700	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HPK20_RS04705	ENOG4105VNG	YcgL domain-containing protein
HPK20_RS04710	ENOG4105CVE	Lytic murein transglycosylase
HPK20_RS04715	ENOG4105EXG	Transcriptional regulator
HPK20_RS04720	ENOG4105D9N	nucleoside
HPK20_RS04725	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HPK20_RS04735	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS04740	ENOG4107RCV	ABC transporter, permease
HPK20_RS04745	ENOG4105C4Y	ABC transporter
HPK20_RS04750	ENOG4105CXY	transporter
HPK20_RS04755	ENOG4105BZU	Histidine kinase
HPK20_RS04760	ENOG4108KX4	response regulator
HPK20_RS04785	ENOG4105DP0	ferredoxin-NADP reductase
HPK20_RS04795	ENOG4108HPI	phosphatidate Cytidylyltransferase
HPK20_RS04815	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HPK20_RS04825	ENOG4105EJQ	L-serine dehydratase
HPK20_RS04830	ENOG4105CNG	UPF0061 protein
HPK20_RS04840	ENOG4105E0F	Histidine kinase
HPK20_RS04850	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HPK20_RS04855	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPK20_RS04860	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
HPK20_RS04865	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPK20_RS04880	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HPK20_RS04885	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPK20_RS04890	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HPK20_RS04895	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HPK20_RS04900	ENOG4105K70	DNA-binding protein
HPK20_RS04905	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HPK20_RS04910	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HPK20_RS04915	ENOG4105CAT	Cytidine monophosphate kinase
HPK20_RS04920	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HPK20_RS04925	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPK20_RS04930	ENOG4105Q4A	inner membrane protein yciS
HPK20_RS04935	ENOG4105CFV	Tetratricopeptide repeat protein
HPK20_RS04940	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HPK20_RS04945	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HPK20_RS04955	ENOG4107R11	Transcriptional regulator
HPK20_RS04965	ENOG4105DCF	alanine dehydrogenase
HPK20_RS04975	ENOG4105CNU	cell division protein FtsK
HPK20_RS04980	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HPK20_RS04990	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HPK20_RS05000	ENOG4108NVR	Methyl-accepting chemotaxis
HPK20_RS05005	ENOG4105K59	histidine triad (HIT) protein
HPK20_RS05030	ENOG4105D0Y	UPF0227 protein
HPK20_RS05035	ENOG4105CEP	NADH dehydrogenase
HPK20_RS05050	ENOG4108JA2	transcriptioN-repair coupling factor
HPK20_RS05060	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPK20_RS05065	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPK20_RS05070	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPK20_RS05080	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HPK20_RS05085	ENOG4105BZ1	(ABC) transporter
HPK20_RS05090	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HPK20_RS05095	ENOG4105W49	UPF0434 protein
HPK20_RS05100	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPK20_RS05105	ENOG4105ED1	spovr family
HPK20_RS05110	ENOG4106AKX	UPF0229 protein
HPK20_RS05115	ENOG4105CYN	Serine protein kinase
HPK20_RS05125	ENOG4105XWI	UPF0304 protein
HPK20_RS05135	ENOG4105F1A	Pyruvate formate-lyase
HPK20_RS05140	ENOG4108NVR	Methyl-accepting chemotaxis
HPK20_RS05150	ENOG4105C6N	Formate acetyltransferase
HPK20_RS05160	ENOG4108JEH	abc transporter atp-binding protein
HPK20_RS05165	ENOG4105E89	ABC transporter
HPK20_RS05170	ENOG4105DSP	amino acid AbC transporter
HPK20_RS05175	ENOG4106YG3	ABC transporter
HPK20_RS05180	ENOG4105CGK	Exodeoxyribonuclease III
HPK20_RS05185	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS05190	ENOG4106428	Protein of unknown function (DUF2496)
HPK20_RS05195	ENOG4108URS	primosomal replication protein n''
HPK20_RS05200	ENOG4105DVT	helicase
HPK20_RS05205	ENOG4105ZU8	porin-like protein H
HPK20_RS05215	ENOG4105K5B	UPF0225 protein
HPK20_RS05220	ENOG4105D58	Diguanylate phosphodiesterase
HPK20_RS05225	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HPK20_RS05230	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPK20_RS05240	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HPK20_RS05245	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HPK20_RS05250	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HPK20_RS05255	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPK20_RS05260	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPK20_RS05275	ENOG4107YD3	Thioesterase
HPK20_RS05280	ENOG4105E02	MotA TolQ exbB proton channel
HPK20_RS05285	ENOG4105M8F	Biopolymer transport protein exbD tolR
HPK20_RS05295	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HPK20_RS05300	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HPK20_RS05305	ENOG4105UFD	tol-pal system protein YbgF
HPK20_RS05310	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HPK20_RS05320	ENOG4105BZU	Histidine kinase
HPK20_RS05325	ENOG4108RNS	Exports L-alanine (By similarity)
HPK20_RS05335	ENOG4105C26	Dehydrogenase
HPK20_RS05350	ENOG41067SE	Tetr family transcriptional regulator
HPK20_RS05355	ENOG4107QPN	acyl-Coa dehydrogenase
HPK20_RS05370	ENOG4105D0C	transport protein
HPK20_RS05375	ENOG41090BQ	Glutaredoxin
HPK20_RS05380	ENOG4107QW4	alcohol dehydrogenase
HPK20_RS05385	ENOG4106KNT	transcriptional regulator
HPK20_RS05390	ENOG4105DY8	decarboxylase
HPK20_RS05400	ENOG4105DWU	Membrane
HPK20_RS05425	ENOG4105CUX	Signal transduction histidine kinase
HPK20_RS05435	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HPK20_RS05440	ENOG4105CCT	upf0313 protein
HPK20_RS05445	ENOG4105C5H	ABC transporter
HPK20_RS05465	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPK20_RS05470	ENOG4105BZU	Histidine kinase
HPK20_RS05475	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPK20_RS05495	ENOG4108N3W	hemolysin secretion protein
HPK20_RS05500	ENOG4105BZU	Histidine kinase
HPK20_RS05510	ENOG4108K3A	Glutathione S-transferase
HPK20_RS05530	ENOG4107RAN	Peptidase, M16
HPK20_RS05545	ENOG4105DZ2	Transcriptional regulator
HPK20_RS05550	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HPK20_RS05560	ENOG4105K9H	YciI-like protein
HPK20_RS05565	ENOG4105NAU	thioesterase Superfamily protein
HPK20_RS05570	ENOG4107835	probably involved in intracellular septation (By similarity)
HPK20_RS05580	ENOG4105CK2	sodium dicarboxylate symporter
HPK20_RS05585	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HPK20_RS05590	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HPK20_RS05595	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HPK20_RS05600	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HPK20_RS05605	ENOG4105DDQ	anthranilate synthase
HPK20_RS05610	ENOG4105CRQ	synthase (Component I)
HPK20_RS05620	ENOG4105DB7	PHP domain protein
HPK20_RS05625	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HPK20_RS05630	ENOG4105FE9	pseudouridine synthase
HPK20_RS05650	ENOG4105DR5	peptidase
HPK20_RS05655	ENOG4108JJ8	(ABC) transporter
HPK20_RS05660	ENOG4108JJ9	ABC, transporter
HPK20_RS05665	ENOG4105C3M	thioredoxin reductase
HPK20_RS05690	ENOG4105C0A	alcohol dehydrogenase
HPK20_RS05695	ENOG4105C26	Dehydrogenase
HPK20_RS05700	ENOG4108FUF	Transcriptional regulator, IclR family
HPK20_RS05705	ENOG4108FUF	Transcriptional regulator, IclR family
HPK20_RS05715	ENOG4107GZ4	SanA protein
HPK20_RS05725	ENOG4108Z4X	TRANSCRIPTIONal
HPK20_RS05740	ENOG4108ZHR	arsR family transcriptional regulator
HPK20_RS05755	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
HPK20_RS05780	ENOG4107R1I	NAD-dependent malic enzyme
HPK20_RS05785	ENOG4105CQ7	ATP-dependent helicase
HPK20_RS05795	ENOG4107S6Z	Na H antiporter
HPK20_RS05800	ENOG4105CFQ	glutamine synthetase
HPK20_RS05805	ENOG4108Z86	Glutamine amidotransferase
HPK20_RS05810	ENOG4107VRI	Transcriptional regulator
HPK20_RS05815	ENOG4105C26	Dehydrogenase
HPK20_RS05820	ENOG4105CJP	fad dependent oxidoreductase
HPK20_RS05830	ENOG4105DWY	Agmatine deiminase
HPK20_RS05835	ENOG4105C26	Dehydrogenase
HPK20_RS05840	ENOG4108JPW	Aminotransferase
HPK20_RS05865	ENOG4108ZG0	Ompa motb domain protein
HPK20_RS05880	ENOG4105CQB	FAD linked oxidase domain protein
HPK20_RS05905	ENOG4105CGP	Urocanate hydratase
HPK20_RS05910	ENOG41088SP	formiminoglutamate hydrolase
HPK20_RS05915	ENOG4105CI2	imidazolone-5-propionate hydrolase
HPK20_RS05920	ENOG4105CZE	histidine utilization repressor
HPK20_RS05925	ENOG41060QA	UPF0267 protein
HPK20_RS05930	ENOG4108W5H	UPF0263 protein
HPK20_RS05935	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPK20_RS05945	ENOG4105BZU	Histidine kinase
HPK20_RS05950	ENOG4105CQ2	DNA polymerase
HPK20_RS05955	ENOG4105WH1	Two component transcriptional regulator luxr family
HPK20_RS05960	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPK20_RS06010	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HPK20_RS06030	ENOG4105FQ6	thiopurine methyltransferase
HPK20_RS06035	ENOG4107SDU	Methyl-accepting chemotaxis
HPK20_RS06060	ENOG4105BZU	Histidine kinase
HPK20_RS06065	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
HPK20_RS06070	ENOG41067MG	lrgb family
HPK20_RS06075	ENOG4105VAW	lrga family
HPK20_RS06080	ENOG4105CJB	Exodeoxyribonuclease I
HPK20_RS06090	ENOG4108ETY	sodium dicarboxylate symporter
HPK20_RS06095	ENOG4105K4T	epimerase
HPK20_RS06100	ENOG4107XWI	flavin reductase domain protein, FMN-binding
HPK20_RS06105	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HPK20_RS06110	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HPK20_RS06115	ENOG4108YZT	Adenosylcobinamide kinase
HPK20_RS06130	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HPK20_RS06135	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS06180	ENOG4105F04	LysR family Transcriptional regulator
HPK20_RS06190	ENOG4108VKG	metal-dependent hydrolase
HPK20_RS06205	ENOG41090FY	type IV pilus biogenesis stability protein PilW
HPK20_RS06210	ENOG4105CVG	Homoserine O-transsuccinylase
HPK20_RS06230	ENOG4107V40	secretion protein, HlyD family
HPK20_RS06245	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPK20_RS06250	ENOG4106YYS	transcriptional regulatory protein
HPK20_RS06260	ENOG4107R88	Chemotaxis protein (CheV)
HPK20_RS06315	ENOG4105VEQ	Cold shock protein
HPK20_RS06330	ENOG4107SDU	Methyl-accepting chemotaxis
HPK20_RS06350	ENOG4105D64	Mechanosensitive ion channel
HPK20_RS06365	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPK20_RS06370	ENOG4105GR3	Histidine kinase
HPK20_RS06420	ENOG4105DR4	Methyltransferase
HPK20_RS06430	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HPK20_RS06435	ENOG4108MN8	Membrane
HPK20_RS06440	ENOG4105CDA	abc transporter atp-binding protein
HPK20_RS06445	ENOG4105DRP	amino acid AbC transporter
HPK20_RS06450	ENOG4105EZ7	amino acid ABC transporter
HPK20_RS06455	ENOG4107QXX	ABC transporter
HPK20_RS06465	ENOG410667J	hydrolase
HPK20_RS06470	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HPK20_RS06475	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HPK20_RS06480	ENOG4105CUW	cytochrome C-TYPE protein
HPK20_RS06485	ENOG4107QY8	reductase
HPK20_RS06515	ENOG4105E9S	glutaredoxin 2
HPK20_RS06530	ENOG4105BZU	Histidine kinase
HPK20_RS06540	ENOG4105BZU	Histidine kinase
HPK20_RS06545	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPK20_RS06550	ENOG4105CFG	Acts as a chaperone (By similarity)
HPK20_RS06560	ENOG4106TD9	Diguanylate cyclase
HPK20_RS06585	ENOG4105CUW	cytochrome C-TYPE protein
HPK20_RS06595	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HPK20_RS06600	ENOG4105CQ7	ATP-dependent helicase
HPK20_RS06610	ENOG4105CTD	carboxy-peptidase
HPK20_RS06615	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPK20_RS06620	ENOG4105CS6	Rhs element vgr protein
HPK20_RS06645	ENOG4105BZG	amino acid carrier protein
HPK20_RS06660	ENOG4105E0X	reductase
HPK20_RS06665	ENOG4108VPT	UPF0234 protein
HPK20_RS06670	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPK20_RS06675	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HPK20_RS06690	ENOG4105QNR	S1 RNA binding domain protein
HPK20_RS06700	ENOG4105DY2	Paraquat-inducible protein b
HPK20_RS06705	ENOG4105H2K	paraquat-inducible protein a
HPK20_RS06710	ENOG4105BZ1	(ABC) transporter
HPK20_RS06715	ENOG4108ZGC	gaf domain protein
HPK20_RS06720	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
HPK20_RS06725	ENOG4105CN1	protease
HPK20_RS06740	ENOG4105CD8	aminopeptidase N
HPK20_RS06750	ENOG4105C7I	Dehydrogenase
HPK20_RS06755	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HPK20_RS06760	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HPK20_RS06765	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HPK20_RS06775	ENOG4105C5H	ABC transporter
HPK20_RS06790	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HPK20_RS06795	ENOG4105DAN	ATP-dependent protease
HPK20_RS06800	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
HPK20_RS06835	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HPK20_RS06850	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HPK20_RS06860	ENOG4105C59	p-type ATPase
HPK20_RS06875	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HPK20_RS06880	ENOG4105Q9Y	Universal stress protein
HPK20_RS06885	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HPK20_RS06905	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS06915	ENOG4105D38	putrescine abc transporter
HPK20_RS06920	ENOG4108HM4	ABC transporter
HPK20_RS06925	ENOG4107RUE	extracellular solute-binding protein family 1
HPK20_RS06930	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HPK20_RS06950	ENOG4105QAX	Iron-sulfur
HPK20_RS06955	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPK20_RS06965	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPK20_RS06985	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPK20_RS07000	ENOG4105BZU	Histidine kinase
HPK20_RS07005	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPK20_RS07015	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS07020	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS07025	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HPK20_RS07030	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPK20_RS07040	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HPK20_RS07045	ENOG4106IUH	DTW domain containing protein
HPK20_RS07055	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS07060	ENOG4107TT5	NLP P60 protein
HPK20_RS07080	ENOG4108R6K	riboflavin synthase, subunit alpha
HPK20_RS07085	ENOG4107QI1	Mate efflux family protein
HPK20_RS07100	ENOG4108NRW	Phospholipase, patatin family
HPK20_RS07120	ENOG4109015	Biopolymer transport protein exbD tolR
HPK20_RS07140	ENOG4105QNF	Outer membrane lipoprotein
HPK20_RS07155	ENOG4105BZ7	extracellular solute-binding protein family 1
HPK20_RS07165	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS07170	ENOG4108IJ9	(ABC) transporter
HPK20_RS07175	ENOG4105E98	transcriptional regulator DeoR family
HPK20_RS07180	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HPK20_RS07185	ENOG4105XEP	YhcH YjgK YiaL family protein
HPK20_RS07205	ENOG4108RXX	maleylacetoacetate isomerase
HPK20_RS07215	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HPK20_RS07220	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HPK20_RS07225	ENOG4107XTP	(EAL) domain protein
HPK20_RS07230	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPK20_RS07245	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPK20_RS07250	ENOG4105CW7	secretion protein, HlyD family
HPK20_RS07260	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPK20_RS07265	ENOG4105C7F	AcnD-accessory protein PrpF
HPK20_RS07270	ENOG4108I0Z	Aconitate hydratase
HPK20_RS07275	ENOG4105BZN	citrate synthase
HPK20_RS07280	ENOG4105CR4	methylisocitrate lyase
HPK20_RS07290	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HPK20_RS07320	ENOG4107SDZ	Galactoside transport system permease protein mglC
HPK20_RS07325	ENOG4105C2J	ABC transporter
HPK20_RS07335	ENOG4105CNT	hydrolase family 2
HPK20_RS07350	ENOG4108RCM	Nitroreductase
HPK20_RS07355	ENOG41067V3	Antibiotic biosynthesis monooxygenase
HPK20_RS07360	ENOG4108PZW	LysR family Transcriptional regulator
HPK20_RS07365	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPK20_RS07370	ENOG4105BZU	Histidine kinase
HPK20_RS07375	ENOG4105C8P	)-transporter
HPK20_RS07395	ENOG4105D9U	N-acetyltransferase
HPK20_RS07400	ENOG4108JU8	Transcriptional regulator
HPK20_RS07405	ENOG4106K28	UPF0283 membrane protein
HPK20_RS07410	ENOG4105CM6	amino acid regulated cytosolic protein
HPK20_RS07425	ENOG4105CRQ	synthase (Component I)
HPK20_RS07430	ENOG4105BZU	Histidine kinase
HPK20_RS07440	ENOG4105P8F	nudix hydrolase
HPK20_RS07445	ENOG4105C44	Serine transporter
HPK20_RS07450	ENOG4105EJQ	L-serine dehydratase
HPK20_RS07455	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HPK20_RS07460	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPK20_RS07465	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HPK20_RS07470	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HPK20_RS07475	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS07480	ENOG4105C5S	asparaginyl-tRNA synthetase
HPK20_RS07500	ENOG4105CGF	Aromatic amino acid aminotransferase
HPK20_RS07510	ENOG41080XP	Cbs domain
HPK20_RS07515	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HPK20_RS07520	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS07525	ENOG4105C94	Transporter
HPK20_RS07530	ENOG41067TZ	transcriptional regulator, MarR family
HPK20_RS07535	ENOG4105WH1	Two component transcriptional regulator luxr family
HPK20_RS07550	ENOG4105CH5	extracellular solute-binding protein, family 7
HPK20_RS07565	ENOG4105C5X	domain protein
HPK20_RS07570	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HPK20_RS07575	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
HPK20_RS07600	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HPK20_RS07610	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPK20_RS07615	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HPK20_RS07620	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPK20_RS07625	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPK20_RS07650	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPK20_RS07655	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HPK20_RS07660	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPK20_RS07670	ENOG4105CH5	extracellular solute-binding protein, family 7
HPK20_RS07680	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS07685	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
HPK20_RS07710	ENOG4105CDV	Ompa motb domain protein
HPK20_RS07715	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPK20_RS07730	ENOG4108I0Y	(ABC) transporter
HPK20_RS07735	ENOG4105UQX	Mate efflux family protein
HPK20_RS07740	ENOG4105CGD	Nad-dependent epimerase dehydratase
HPK20_RS07750	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPK20_RS07755	ENOG4105I08	Pseudouridine synthase
HPK20_RS07760	ENOG4105CFI	type iii restriction protein res subunit
HPK20_RS07770	ENOG4105ETX	regulatoR
HPK20_RS07775	ENOG4105EB3	Histidine kinase
HPK20_RS07780	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HPK20_RS07815	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPK20_RS07820	ENOG4105C4X	radical SAM domain protein
HPK20_RS07825	ENOG4105ENH	Sulfatase
HPK20_RS07835	ENOG4105C94	Transporter
HPK20_RS07845	ENOG4105VEQ	Cold shock protein
HPK20_RS07860	ENOG4105BZU	Histidine kinase
HPK20_RS07875	ENOG4105C44	Serine transporter
HPK20_RS07885	ENOG4105CJ1	ABC, transporter
HPK20_RS07890	ENOG4107QWP	ABC-2 type transporter
HPK20_RS07900	ENOG4105XZD	Fe-S protein
HPK20_RS07910	ENOG4105VNH	ABC transporter solute-binding protein
HPK20_RS07915	ENOG4105CXZ	ABC transporter, permease
HPK20_RS07920	ENOG4108VGW	abc transporter atp-binding protein
HPK20_RS07925	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HPK20_RS07930	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HPK20_RS07940	ENOG4108W1A	pseudouridine synthase
HPK20_RS07955	ENOG4105C9Q	fumarate hydratase class II
HPK20_RS07960	ENOG4105C8J	)-transporter
HPK20_RS07970	ENOG4105C28	cystathionine
HPK20_RS07980	ENOG4107QX9	Thiol disulfide interChange protein
HPK20_RS08000	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPK20_RS08015	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HPK20_RS08025	ENOG4105YYT	phage shock protein B
HPK20_RS08030	ENOG41087YS	Phage shock protein A
HPK20_RS08035	ENOG4105E51	psp operon transcriptional activator
HPK20_RS08040	ENOG4108J59	Extracellular solute-binding protein, family 5
HPK20_RS08045	ENOG4108I5W	peptide transport system, permease protein
HPK20_RS08050	ENOG4108EU3	peptide transport system, permease
HPK20_RS08055	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HPK20_RS08060	ENOG4108JQ2	peptide transport system atp-binding protein
HPK20_RS08075	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HPK20_RS08095	ENOG4107QY8	reductase
HPK20_RS08115	ENOG4105TMB	Formate nitrite transporter
HPK20_RS08135	ENOG4107SRH	Nad-dependent epimerase dehydratase
HPK20_RS08140	ENOG4105GFG	DUF218 domain
HPK20_RS08145	ENOG4107104	thymidine kinase
HPK20_RS08150	ENOG4105C9M	aspartyl-trna synthetase
HPK20_RS08165	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HPK20_RS08170	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPK20_RS08180	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPK20_RS08185	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
HPK20_RS08190	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HPK20_RS08195	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HPK20_RS08200	ENOG4106371	Methyltransferase
HPK20_RS08205	ENOG4107S90	membrAne
HPK20_RS08210	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HPK20_RS08215	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPK20_RS08220	ENOG4105ETE	Transcriptional regulator (LacI family
HPK20_RS08225	ENOG4105HP8	regulator of competence-specific genes
HPK20_RS08245	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HPK20_RS08250	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPK20_RS08260	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPK20_RS08265	ENOG4105RKX	Protein of unknown function (DUF2498)
HPK20_RS08280	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HPK20_RS08285	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HPK20_RS08290	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HPK20_RS08295	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPK20_RS08300	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HPK20_RS08305	ENOG4105VEQ	Cold shock protein
HPK20_RS08315	ENOG4108R99	pseudouridine synthase
HPK20_RS08320	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HPK20_RS08325	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HPK20_RS08340	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HPK20_RS08345	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPK20_RS08350	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HPK20_RS08355	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HPK20_RS08360	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPK20_RS08365	ENOG4107S6Z	Na H antiporter
HPK20_RS08375	ENOG4107RE1	Inosine-guanosine kinase
HPK20_RS08380	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HPK20_RS08385	ENOG41075W9	High frequency lysogenization protein HflD homolog
HPK20_RS08390	ENOG4107QTF	adenylosuccinate lyase
HPK20_RS08410	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HPK20_RS08425	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HPK20_RS08435	ENOG4105D0M	Protease HtpX homolog
HPK20_RS08445	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HPK20_RS08450	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HPK20_RS08455	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPK20_RS08460	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HPK20_RS08465	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HPK20_RS08475	ENOG4107QZF	nitrite reductase NADPH large subunit
HPK20_RS08480	ENOG4105D7T	ABC transporter
HPK20_RS08485	ENOG4105DG7	nitrate ABC transporter
HPK20_RS08505	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPK20_RS08520	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HPK20_RS08525	ENOG4105D1H	recombination factor protein RarA
HPK20_RS08535	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPK20_RS08545	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HPK20_RS08550	ENOG4105BZU	Histidine kinase
HPK20_RS08555	ENOG4108JJB	ABC transporter
HPK20_RS08560	ENOG4105C7J	ABC transporter, permease
HPK20_RS08570	ENOG4105PQ6	UPF0208 membrane protein
HPK20_RS08575	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPK20_RS08580	ENOG4108DNC	Involved in acetate metabolism (By similarity)
HPK20_RS08585	ENOG4107PU6	Membrane
HPK20_RS08590	ENOG4105CHF	Glutathione S-transferase
HPK20_RS08600	ENOG4108JQ7	(ABC) transporter
HPK20_RS08605	ENOG4105C3U	ABC transporter
HPK20_RS08610	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS08615	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS08620	ENOG4107QSI	ABC, transporter
HPK20_RS08645	ENOG4105CEY	Amp-dependent synthetase and ligase
HPK20_RS08650	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPK20_RS08665	ENOG4105CEY	Amp-dependent synthetase and ligase
HPK20_RS08675	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HPK20_RS08680	ENOG4105C84	Histidine ammonia-lyase
HPK20_RS08705	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPK20_RS08715	ENOG4105C2D	reductase
HPK20_RS08720	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPK20_RS08730	ENOG4105D7K	pfkb domain protein
HPK20_RS08735	ENOG4108M0B	Sucrose porin
HPK20_RS08740	ENOG4105BZU	Histidine kinase
HPK20_RS08745	ENOG4108HKT	sucrose-6-phosphate hydrolase
HPK20_RS08755	ENOG4105C5Y	PTS System
HPK20_RS08765	ENOG4105ETX	regulatoR
HPK20_RS08775	ENOG4105UEI	Transcriptional Regulator AraC Family
HPK20_RS08780	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPK20_RS08785	ENOG4105CW7	secretion protein, HlyD family
HPK20_RS08790	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HPK20_RS08800	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
HPK20_RS08805	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS08810	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS08815	ENOG4108JQ5	ABC transporter
HPK20_RS08820	ENOG4105DWF	phosphomethylpyrimidine kinase
HPK20_RS08825	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
HPK20_RS08830	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HPK20_RS08835	ENOG4105C2I	pirin domain protein
HPK20_RS08840	ENOG4105CS2	ec 3.2.1.21
HPK20_RS08845	ENOG4105DDV	Transcriptional regulator (LacI family
HPK20_RS08855	ENOG4105E0A	ABC, transporter
HPK20_RS08860	ENOG4105CEY	Amp-dependent synthetase and ligase
HPK20_RS08870	ENOG4107RBR	Receptor
HPK20_RS08875	ENOG4105TVJ	transport system, permease
HPK20_RS08880	ENOG4105DQ5	transport system permease protein
HPK20_RS08885	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
HPK20_RS08900	ENOG4105C0W	non-ribosomal peptide synthetase
HPK20_RS08910	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HPK20_RS08915	ENOG4105E4F	Isochorismate synthase
HPK20_RS08920	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPK20_RS08925	ENOG4105WQI	isochorismatase
HPK20_RS08930	ENOG4105F27	Major Facilitator
HPK20_RS08935	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPK20_RS08975	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPK20_RS08980	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPK20_RS08985	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPK20_RS08990	ENOG4105BZU	Histidine kinase
HPK20_RS09000	ENOG4105NQN	cytochrome C
HPK20_RS09010	ENOG4105DB1	molybdopterin oxidoreductase
HPK20_RS09015	ENOG4106WHD	Tetrathionate reductase
HPK20_RS09020	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HPK20_RS09025	ENOG4106AFQ	Histidine kinase
HPK20_RS09050	ENOG4105DIJ	Phosphoethanolamine transferase
HPK20_RS09055	ENOG41080IJ	Diacylglycerol kinase
HPK20_RS09060	ENOG4105E0M	Sulfatase
HPK20_RS09065	ENOG4105C1J	atp-dependent rna helicase
HPK20_RS09075	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
HPK20_RS09080	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPK20_RS09085	ENOG4105DHQ	Histidine kinase
HPK20_RS09100	ENOG410624V	efflux system protein
HPK20_RS09105	ENOG4108IJF	Heavy metal efflux pump, CzcA
HPK20_RS09115	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HPK20_RS09135	ENOG4108UQN	AraC family transcriptional regulator
HPK20_RS09140	ENOG4108V1U	phospholipid-binding protein
HPK20_RS09145	ENOG4105DQU	oxidoreductase, subunit beta
HPK20_RS09150	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
HPK20_RS09155	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPK20_RS09160	ENOG4105R1U	AraC Family Transcriptional Regulator
HPK20_RS09195	ENOG4108KTG	Membrane protein, drug metabolite transporter
HPK20_RS09200	ENOG4108YYH	Nadph-dependent fmn reductase
HPK20_RS09215	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HPK20_RS09235	ENOG4105E7U	AraC family transcriptional regulator
HPK20_RS09240	ENOG4105ENX	hydrolase
HPK20_RS09245	ENOG4105CHR	reductase
HPK20_RS09250	ENOG4105CHR	reductase
HPK20_RS09255	ENOG4105E1F	short-chain dehydrogenase reductase
HPK20_RS09265	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HPK20_RS09270	ENOG4105EMU	Dehydrogenase
HPK20_RS09290	ENOG4105R8C	Transcriptional regulator
HPK20_RS09310	ENOG410620I	Diguanylate cyclase
HPK20_RS09325	ENOG4108MNP	Glycoprotein polysaccharide metabolism
HPK20_RS09330	ENOG4105C29	acyl-CoA thioesterase
HPK20_RS09335	ENOG4108XM1	transcriptional regulator AsnC family
HPK20_RS09350	ENOG4108JIR	Flagellum-specific ATP synthase
HPK20_RS09360	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPK20_RS09365	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HPK20_RS09380	ENOG41090EK	ompa motb domain protein
HPK20_RS09390	ENOG4105DD5	Flagellar motor switch protein
HPK20_RS09395	ENOG4105CN7	Flagellar biosynthetic protein FliP
HPK20_RS09400	ENOG4105VS8	Flagellar biosynthetic protein fliq
HPK20_RS09405	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HPK20_RS09410	ENOG4105D00	flagellar biosynthetic protein flhB
HPK20_RS09425	ENOG4105I03	Flagellin
HPK20_RS09430	ENOG410804A	Flagellar hook-associated 2 domain-containing protein
HPK20_RS09460	ENOG4107RD7	Flagellar Motor Protein, MotA
HPK20_RS09465	ENOG4105ER2	Ompa motb domain protein
HPK20_RS09480	ENOG4107S9F	NmrA family
HPK20_RS09510	ENOG4105E1Q	flagellar hook-associated protein
HPK20_RS09515	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HPK20_RS09520	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPK20_RS09525	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPK20_RS09530	ENOG4105CGA	flagellar basal-body rod protein FlgG
HPK20_RS09535	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HPK20_RS09540	ENOG4105BZE	flagellar hook protein, FlgE
HPK20_RS09545	ENOG4105W00	Flagellar hook capping protein
HPK20_RS09550	ENOG4108ZC9	flagellar basal-body rod protein flgc
HPK20_RS09555	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HPK20_RS09575	ENOG4105E9H	Lytic Murein transglycosylase
HPK20_RS09580	ENOG4105F4I	Transcriptional regulator
HPK20_RS09600	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
HPK20_RS09605	ENOG4105HMI	Membrane
HPK20_RS09615	ENOG4105CEY	Amp-dependent synthetase and ligase
HPK20_RS09625	ENOG4108IPT	Naphthoate synthase
HPK20_RS09630	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HPK20_RS09635	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HPK20_RS09640	ENOG4105E4F	Isochorismate synthase
HPK20_RS09645	ENOG4105CHM	Aminotransferase
HPK20_RS09650	ENOG4105DK2	UPF0207 protein
HPK20_RS09655	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPK20_RS09700	ENOG4105ERU	peptidase
HPK20_RS09705	ENOG4105UBK	short-chain dehydrogenase reductase
HPK20_RS09720	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPK20_RS09730	ENOG4105DAG	ROK family
HPK20_RS09735	ENOG4105CA9	Pyruvate kinase
HPK20_RS09740	ENOG4108NRW	Phospholipase, patatin family
HPK20_RS09755	ENOG4105C8J	)-transporter
HPK20_RS09770	ENOG4105CI1	PTS System
HPK20_RS09785	ENOG4105F8V	Hydrolase, tatD family
HPK20_RS09790	ENOG4107QRG	dna polymerase iii
HPK20_RS09795	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HPK20_RS09800	ENOG4105HHA	aminodeoxychorismate lyase
HPK20_RS09805	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HPK20_RS09810	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPK20_RS09815	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPK20_RS09820	ENOG4105CHR	reductase
HPK20_RS09825	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HPK20_RS09835	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HPK20_RS09845	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HPK20_RS09850	ENOG4108UHJ	MAF-like protein
HPK20_RS09855	ENOG4105EI2	Pseudouridine synthase
HPK20_RS09860	ENOG4105C03	ribonuclease
HPK20_RS09870	ENOG4105CHH	sulfate transporter
HPK20_RS09880	ENOG4105C0A	alcohol dehydrogenase
HPK20_RS09885	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HPK20_RS09890	ENOG4105EYW	Ion transport protein
HPK20_RS09895	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPK20_RS09900	ENOG4105DFD	Na H antiporter
HPK20_RS09915	ENOG4106V8H	Nucleoid-associated protein
HPK20_RS09920	ENOG4105YDX	UPF0352 protein
HPK20_RS09925	ENOG4105E68	Sulfatase
HPK20_RS09940	ENOG4105CGF	Aromatic amino acid aminotransferase
HPK20_RS09950	ENOG4105DGU	Histone deacetylase
HPK20_RS09960	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HPK20_RS09965	ENOG4105E2X	shikimate dehydrogenase
HPK20_RS09995	ENOG4105GAK	amidohydrolase 2
HPK20_RS10005	ENOG4105JSC	dimethylmenaquinone methyltransferase
HPK20_RS10010	ENOG4105KHM	amidohydrolase 2
HPK20_RS10015	ENOG4105DDW	LysR family Transcriptional regulator
HPK20_RS10030	ENOG4105CPC	Aldo Keto reductase
HPK20_RS10045	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPK20_RS10060	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPK20_RS10065	ENOG4105M2J	Glutaredoxin
HPK20_RS10070	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPK20_RS10085	ENOG410903C	(LipO)protein
HPK20_RS10090	ENOG4108M1T	Cytochrome c-type biogenesis protein
HPK20_RS10095	ENOG4108M1T	Cytochrome c-type biogenesis protein
HPK20_RS10100	ENOG4107QX9	Thiol disulfide interChange protein
HPK20_RS10105	ENOG4105DA4	cytochrome c-type biogenesis protein
HPK20_RS10110	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HPK20_RS10115	ENOG4105X3C	heme exporter protein
HPK20_RS10120	ENOG41060IM	Heme exporter protein
HPK20_RS10125	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HPK20_RS10130	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS10140	ENOG4108V3W	Chemotaxis protein, CheW
HPK20_RS10150	ENOG4107QJE	Chromosome Partitioning Protein
HPK20_RS10155	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPK20_RS10165	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HPK20_RS10170	ENOG4108VYJ	response regulator receiver protein
HPK20_RS10175	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPK20_RS10185	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HPK20_RS10190	ENOG4105D7B	Flagellar biosynthesis protein flha
HPK20_RS10195	ENOG4108BY2	phosphohistidine phosphatase
HPK20_RS10200	ENOG4107QXK	peptidase
HPK20_RS10205	ENOG4106ZCM	YecM protein
HPK20_RS10210	ENOG4105C75	arginyL-tRNA synthetase
HPK20_RS10230	ENOG4105XFK	Ferrous iron transport protein A
HPK20_RS10240	ENOG4105NXV	High-affinity zinc uptake system protein
HPK20_RS10245	ENOG4105FDK	ABC transporter
HPK20_RS10250	ENOG4105FAV	ABC, transporter
HPK20_RS10255	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HPK20_RS10260	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HPK20_RS10265	ENOG4105C7S	Dehydrogenase
HPK20_RS10270	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HPK20_RS10275	ENOG4105E33	succinate dehydrogenase
HPK20_RS10280	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HPK20_RS10285	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HPK20_RS10290	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HPK20_RS10295	ENOG4105BZN	citrate synthase
HPK20_RS10300	ENOG4107QNR	UPF0135 protein
HPK20_RS10310	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HPK20_RS10315	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HPK20_RS10320	ENOG4105EV9	Alpha Beta Hydrolase
HPK20_RS10330	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HPK20_RS10335	ENOG41067MG	lrgb family
HPK20_RS10340	ENOG4105VAW	lrga family
HPK20_RS10345	ENOG4105CMU	LysR family (Transcriptional regulator
HPK20_RS10355	ENOG41090R7	Ferric uptake
HPK20_RS10360	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPK20_RS10365	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HPK20_RS10370	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPK20_RS10375	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HPK20_RS10385	ENOG4105MH2	YfcL protein
HPK20_RS10390	ENOG4108BPE	-transporting atpase
HPK20_RS10395	ENOG4105EN6	Membrane
HPK20_RS10400	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HPK20_RS10405	ENOG4105EJC	lysr family transcriptional regulator
HPK20_RS10410	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HPK20_RS10415	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HPK20_RS10420	ENOG4108DG9	Smr protein MutS2
HPK20_RS10425	ENOG4105D00	flagellar biosynthetic protein flhB
HPK20_RS10430	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HPK20_RS10435	ENOG4105VS8	Flagellar biosynthetic protein fliq
HPK20_RS10440	ENOG4105CN7	Flagellar biosynthetic protein FliP
HPK20_RS10445	ENOG4105VTB	flagellar biosynthesis protein fliO
HPK20_RS10450	ENOG4105DD5	Flagellar motor switch protein
HPK20_RS10455	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPK20_RS10475	ENOG4108JIR	Flagellum-specific ATP synthase
HPK20_RS10485	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPK20_RS10490	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HPK20_RS10495	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HPK20_RS10505	ENOG4105BZU	Histidine kinase
HPK20_RS10515	ENOG4105MQ3	flagellar protein FliS
HPK20_RS10525	ENOG4107BRV	flagellar capping protein
HPK20_RS10530	ENOG41063QE	flagellar protein FlaG
HPK20_RS10535	ENOG4105I03	Flagellin
HPK20_RS10540	ENOG4105I03	Flagellin
HPK20_RS10545	ENOG4105I03	Flagellin
HPK20_RS10550	ENOG4105EZR	dyp-type peroxidase family protein
HPK20_RS10555	ENOG4105QZU	Inner membrane protein YfeZ
HPK20_RS10575	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HPK20_RS10580	ENOG4105CMR	udp-glucose 4-epimerase
HPK20_RS10590	ENOG4105KUZ	arsenate reductase
HPK20_RS10610	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPK20_RS10620	ENOG4105RH4	Glycine cleavage system transcriptional repressor
HPK20_RS10650	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPK20_RS10670	ENOG4105CAF	HipA N-terminal domain protein
HPK20_RS10705	ENOG4108ZXE	
HPK20_RS10725	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPK20_RS10730	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS10745	ENOG4105ERG	peptidase m48, ste24p
HPK20_RS10750	ENOG4105K89	arsenate reductase
HPK20_RS10755	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HPK20_RS10770	ENOG4105C2W	permease
HPK20_RS10775	ENOG4108Z66	YbaK ebsC protein
HPK20_RS10780	ENOG4105CGH	5'-nucleotidase
HPK20_RS10790	ENOG41063JG	Transcriptional regulator
HPK20_RS10795	ENOG4108YY7	Invasion gene expression up-regulator SirB
HPK20_RS10800	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPK20_RS10805	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HPK20_RS10810	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HPK20_RS10815	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HPK20_RS10820	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HPK20_RS10825	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HPK20_RS10830	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HPK20_RS10835	ENOG4105C3G	gtp-binding protein
HPK20_RS10925	ENOG4105I03	Flagellin
HPK20_RS10930	ENOG4105I03	Flagellin
HPK20_RS10945	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HPK20_RS10950	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPK20_RS10955	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPK20_RS10960	ENOG4105CGA	flagellar basal-body rod protein FlgG
HPK20_RS10965	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HPK20_RS10970	ENOG4105BZE	flagellar hook protein, FlgE
HPK20_RS10975	ENOG4105W00	Flagellar hook capping protein
HPK20_RS10980	ENOG4108ZC9	flagellar basal-body rod protein flgc
HPK20_RS10985	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HPK20_RS10990	ENOG4105BZU	Histidine kinase
HPK20_RS10995	ENOG4107R88	Chemotaxis protein (CheV)
HPK20_RS11040	ENOG4105DIJ	Phosphoethanolamine transferase
HPK20_RS11045	ENOG41080IJ	Diacylglycerol kinase
HPK20_RS11060	ENOG4105UYK	outer membrane protein a
HPK20_RS11065	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HPK20_RS11070	ENOG4105C59	p-type ATPase
HPK20_RS11080	ENOG4105E2D	ec 3.2.1.52
HPK20_RS11100	ENOG4108DG9	Smr protein MutS2
HPK20_RS11105	ENOG4105FE9	pseudouridine synthase
HPK20_RS11115	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HPK20_RS11120	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HPK20_RS11125	ENOG4105E7A	Glutamine amidotransferase
HPK20_RS11130	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPK20_RS11135	ENOG4107QPN	acyl-Coa dehydrogenase
HPK20_RS11145	ENOG4107RZZ	dna polymerase iii epsilon subunit
HPK20_RS11150	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPK20_RS11155	ENOG4105D1A	Methyltransferase
HPK20_RS11160	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HPK20_RS11165	ENOG4105E9H	Lytic Murein transglycosylase
HPK20_RS11175	ENOG4107NA1	Endonuclease Exonuclease phosphatase
HPK20_RS11180	ENOG4108YZA	Nitrogen regulatory protein pii
HPK20_RS11185	ENOG4105N7H	Cytochrome
HPK20_RS11190	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HPK20_RS11195	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HPK20_RS11200	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPK20_RS11210	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPK20_RS11215	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPK20_RS11220	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HPK20_RS11225	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPK20_RS11230	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HPK20_RS11235	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_RS11240	ENOG4105DZP	Membrane-associated zinc metalloprotease
HPK20_RS11245	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HPK20_RS11250	ENOG4105KNE	Phosphatidate cytidylyltransferase
HPK20_RS11255	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPK20_RS11260	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HPK20_RS11265	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HPK20_RS11280	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HPK20_RS11285	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HPK20_RS11290	ENOG4108T8E	UPF0325 protein
HPK20_RS11295	ENOG4108ZAI	phosphatidylglycerophosphatase a
HPK20_RS11300	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HPK20_RS11305	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HPK20_RS11325	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPK20_RS11330	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HPK20_RS11335	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HPK20_RS11340	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HPK20_RS11345	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HPK20_RS11350	ENOG4108DJV	Fermentation respiration switch protein
HPK20_RS11355	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HPK20_RS11360	ENOG4105C7N	Xanthine uracil vitamin C permease
HPK20_RS11365	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPK20_RS11375	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
HPK20_RS11380	ENOG4105C26	Dehydrogenase
HPK20_RS11385	ENOG4108JPW	Aminotransferase
HPK20_RS11390	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPK20_RS11395	ENOG4105CIN	aminoacyl-histidine dipeptidase
HPK20_RS11400	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPK20_RS11405	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPK20_RS11415	ENOG4105C8J	)-transporter
HPK20_RS11430	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HPK20_RS11445	ENOG4105CJ2	(LipO)protein
HPK20_RS11450	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HPK20_RS11455	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPK20_RS11460	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPK20_RS11465	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPK20_RS11470	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPK20_RS11475	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPK20_RS11480	ENOG4105M85	Bola protein
HPK20_RS11485	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPK20_RS11495	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPK20_RS11565	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS11570	ENOG4108Z6B	deaminase
HPK20_RS11580	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPK20_RS11585	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HPK20_RS11590	ENOG4105C34	Pseudouridine synthase
HPK20_RS11595	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_RS11600	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HPK20_RS11605	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HPK20_RS11615	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
HPK20_RS11620	ENOG4108K0B	C-di-gmp phosphodiesterase
HPK20_RS11635	ENOG4107SC1	transglycosylase
HPK20_RS11640	ENOG4105C5H	ABC transporter
HPK20_RS11655	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPK20_RS11660	ENOG4108HRK	Histidine kinase
HPK20_RS11665	ENOG4108NEV	two component transcriptional regulator, LytTR family
HPK20_RS11670	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
HPK20_RS11675	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HPK20_RS11680	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPK20_RS11700	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HPK20_RS11705	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HPK20_RS11710	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HPK20_RS11720	ENOG4105DTN	riboflavin biosynthesis protein ribF
HPK20_RS11725	ENOG4105CJR	Integral membrane protein (MviN
HPK20_RS11735	ENOG41080HT	Transcriptional regulator, arsr family
HPK20_RS11740	ENOG41063Z6	transcriptional regulator, lysR family
HPK20_RS11750	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HPK20_RS11755	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HPK20_RS11760	ENOG4105HF0	Membrane
HPK20_RS11765	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HPK20_RS11770	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPK20_RS11785	ENOG4105CPC	Aldo Keto reductase
HPK20_RS11795	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPK20_RS11800	ENOG4105CRK	lysyL-tRNA synthetase
HPK20_RS11810	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPK20_RS11815	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HPK20_RS11820	ENOG4105C1J	atp-dependent rna helicase
HPK20_RS11830	ENOG4105BZU	Histidine kinase
HPK20_RS11835	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HPK20_RS11845	ENOG4108YYD	acetyltransferase
HPK20_RS11855	ENOG4105BZU	Histidine kinase
HPK20_RS11870	ENOG4105C3S	Mate efflux family protein
HPK20_RS11885	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HPK20_RS11895	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HPK20_RS11900	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HPK20_RS11905	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HPK20_RS11910	ENOG4105CHV	Transcription elongation factor NusA
HPK20_RS11915	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HPK20_RS11930	ENOG4105NTZ	Preprotein translocase subunit SecG
HPK20_RS11935	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HPK20_RS11940	ENOG4105EEI	dihydropteroate synthase
HPK20_RS11945	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HPK20_RS11955	ENOG4105HBR	Rna-binding protein
HPK20_RS11960	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HPK20_RS11965	ENOG4107QE9	Inherit from COG: Membrane
HPK20_RS11970	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HPK20_RS11975	ENOG4105CJW	magnesium transporter
HPK20_RS11985	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPK20_RS11990	ENOG4105DR5	peptidase
HPK20_RS12005	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HPK20_RS12010	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPK20_RS12020	ENOG4105IPI	Membrane
HPK20_RS12025	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPK20_RS12035	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPK20_RS12045	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS12050	ENOG4105C3U	ABC transporter
HPK20_RS12055	ENOG4108JQ7	(ABC) transporter
HPK20_RS12065	ENOG4105RD7	BadF BadG BcrA BcrD
HPK20_RS12070	ENOG4105E2D	ec 3.2.1.52
HPK20_RS12075	ENOG4105E2V	Glycosyltransferase 36
HPK20_RS12085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS12110	ENOG4105XTV	UPF0231 protein
HPK20_RS12115	ENOG4107QIJ	Aconitate hydratase 2
HPK20_RS12120	ENOG4105D78	K07001 NTE family protein
HPK20_RS12125	ENOG4105BZ4	penicillin-binding protein
HPK20_RS12130	ENOG4105CQ7	ATP-dependent helicase
HPK20_RS12135	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HPK20_RS12145	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HPK20_RS12150	ENOG4105DJ0	Poly(A) Polymerase
HPK20_RS12155	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPK20_RS12160	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HPK20_RS12165	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HPK20_RS12170	ENOG4105E3A	(ABC) transporter
HPK20_RS12175	ENOG4105DA5	(ABC) transporter
HPK20_RS12180	ENOG41077A9	carbonic anhydrase
HPK20_RS12185	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPK20_RS12190	ENOG410630P	Transcriptional regulator
HPK20_RS12195	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPK20_RS12200	ENOG4107QSN	dihydrolipoamide acetyltransferase
HPK20_RS12205	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HPK20_RS12210	ENOG41073TP	transcriptional regulator
HPK20_RS12215	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HPK20_RS12220	ENOG4105T95	Thiol disulfide interChange protein
HPK20_RS12225	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPK20_RS12230	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HPK20_RS12240	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HPK20_RS12245	ENOG4105X0D	Fimbrial protein
HPK20_RS12250	ENOG4107QHF	type ii secretion system protein e
HPK20_RS12255	ENOG4105D7Q	type ii secretion system
HPK20_RS12260	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HPK20_RS12265	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HPK20_RS12270	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HPK20_RS12285	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPK20_RS12290	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPK20_RS12295	ENOG4105IPS	esterase
HPK20_RS12300	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HPK20_RS12305	ENOG4108SX3	cytoplasmic protein
HPK20_RS12310	ENOG41087AY	ADP-Ribose pyrophosphatase
HPK20_RS12315	ENOG4105DFG	type I secretion outer membrane protein
HPK20_RS12325	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HPK20_RS12330	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HPK20_RS12335	ENOG4108NVR	Methyl-accepting chemotaxis
HPK20_RS12340	ENOG4105EYW	Ion transport protein
HPK20_RS12345	ENOG4105I7R	Adenylate cyclase
HPK20_RS12350	ENOG4107IX6	phosphate transport regulator
HPK20_RS12355	ENOG4105CJ3	phosphate transporter
HPK20_RS12360	ENOG4106MWK	domain protein
HPK20_RS12375	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HPK20_RS12385	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HPK20_RS12390	ENOG4105DXN	mazG family
HPK20_RS12395	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPK20_RS12400	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HPK20_RS12405	ENOG4105BZU	Histidine kinase
HPK20_RS12410	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HPK20_RS12415	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HPK20_RS12420	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HPK20_RS12425	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HPK20_RS12430	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HPK20_RS12435	ENOG4105C3F	Signal peptidase i
HPK20_RS12440	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HPK20_RS12445	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
HPK20_RS12460	ENOG4105EMN	RNA polymerase sigma factor
HPK20_RS12465	ENOG4108IYU	L-aspartate oxidase
HPK20_RS12475	ENOG4105Y75	tpr repeat protein
HPK20_RS12495	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPK20_RS12500	ENOG4105D0A	hydroxylase
HPK20_RS12510	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HPK20_RS12520	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HPK20_RS12525	ENOG4105E66	phosphoriboisomerase A
HPK20_RS12530	ENOG4108JQ1	Dehydrogenase
HPK20_RS12535	ENOG4108ZP8	Acetolactate synthase small subunit
HPK20_RS12540	ENOG4105C7K	acetolactate synthase
HPK20_RS12545	ENOG4108IQE	Amp-dependent synthetase and ligase
HPK20_RS12550	ENOG41064T2	transcriptional regulator, lysR family
HPK20_RS12575	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HPK20_RS12580	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPK20_RS12585	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPK20_RS12630	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPK20_RS12640	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
HPK20_RS12745	ENOG4108SAU	DNA-binding protein H-ns
HPK20_RS12805	ENOG4105BZU	Histidine kinase
HPK20_RS12815	ENOG4108K5H	permease YjgP YjgQ family protein
HPK20_RS12820	ENOG4108M8S	permease YjgP YjgQ family protein
HPK20_RS12835	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HPK20_RS12840	ENOG4105C5I	Dehydrogenase
HPK20_RS12845	ENOG4105D3G	Pseudouridine synthase
HPK20_RS12850	ENOG4105K3M	)-transporter
HPK20_RS12855	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
HPK20_RS12860	ENOG4108IAB	Phoh family
HPK20_RS12865	ENOG4105DBV	ornithine carbamoyltransferase
HPK20_RS12870	ENOG4105CXT	aspartate transcarbamylase
HPK20_RS12880	ENOG4105KME	endoribonuclease L-psp
HPK20_RS12885	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HPK20_RS12890	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HPK20_RS12895	ENOG4105VFK	BolA family
HPK20_RS12900	ENOG4105UE2	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
HPK20_RS12905	ENOG4105E3I	toluene tolerance
HPK20_RS12910	ENOG4107PE3	Mammalian cell entry related domain protein
HPK20_RS12915	ENOG4105CY3	ABC transporter, permease
HPK20_RS12920	ENOG4105DHJ	ABC, transporter
HPK20_RS12930	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPK20_RS12945	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HPK20_RS12950	ENOG4108IUZ	ABC transporter
HPK20_RS12955	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPK20_RS12960	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HPK20_RS12965	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HPK20_RS12970	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HPK20_RS12975	ENOG41080Z8	PHOSPHOCARRIER protein
HPK20_RS12980	ENOG4105CJW	magnesium transporter
HPK20_RS12985	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HPK20_RS12990	ENOG4105N42	UPF0307 protein
HPK20_RS12995	ENOG4107T0D	ABC, transporter
HPK20_RS13000	ENOG4106SMU	thiamine transporter membrane protein
HPK20_RS13010	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HPK20_RS13015	ENOG4105DFU	Cell wall formation (By similarity)
HPK20_RS13020	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPK20_RS13025	ENOG4105F0N	pyrophosphate phospho-hydrolase
HPK20_RS13030	ENOG41066HZ	AIG2-like family
HPK20_RS13040	ENOG4105CFU	surface antigen
HPK20_RS13045	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPK20_RS13050	ENOG4108UUE	Transcriptional regulator
HPK20_RS13065	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPK20_RS13085	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
HPK20_RS13090	ENOG4107QWE	)-transporter
HPK20_RS13095	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HPK20_RS13100	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HPK20_RS13105	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPK20_RS13110	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HPK20_RS13120	ENOG4105C1J	atp-dependent rna helicase
HPK20_RS13125	ENOG4107YB6	acetyltransferase, (GNAT) family
HPK20_RS13130	ENOG4105DFI	Membrane
HPK20_RS13135	ENOG4105FHY	Opacity-associated protein A
HPK20_RS13140	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPK20_RS13150	ENOG4108ZT0	50S ribosomal protein l17
HPK20_RS13155	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPK20_RS13160	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HPK20_RS13165	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HPK20_RS13180	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HPK20_RS13185	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HPK20_RS13190	ENOG4105VPB	50S ribosomal protein L30
HPK20_RS13195	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HPK20_RS13200	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HPK20_RS13215	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPK20_RS13220	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPK20_RS13225	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HPK20_RS13230	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HPK20_RS13240	ENOG41083MP	50s ribosomal protein l29
HPK20_RS13250	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HPK20_RS13255	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HPK20_RS13260	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HPK20_RS13270	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HPK20_RS13275	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HPK20_RS13280	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HPK20_RS13285	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HPK20_RS13290	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HPK20_RS13295	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPK20_RS13300	ENOG4105E68	Sulfatase
HPK20_RS13305	ENOG4108UV7	flagellar protein motX
HPK20_RS13310	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPK20_RS13315	ENOG4105D44	asparaginase
HPK20_RS13320	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HPK20_RS13325	ENOG4105VKU	nucleicacid-binding protein
HPK20_RS13330	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HPK20_RS13335	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPK20_RS13340	ENOG4105C5H	ABC transporter
HPK20_RS13350	ENOG4105DNZ	Alpha Beta Hydrolase
HPK20_RS13360	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HPK20_RS13365	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HPK20_RS13375	ENOG4105C26	Dehydrogenase
HPK20_RS13385	ENOG4105C8Y	Acetylornithine aminotransferase
HPK20_RS13390	ENOG4105DDQ	anthranilate synthase
HPK20_RS13395	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
HPK20_RS13405	ENOG4105C31	Tryptophanyl-tRNA synthetase
HPK20_RS13410	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPK20_RS13415	ENOG4105DJV	ribulose-phosphate 3-epimerase
HPK20_RS13420	ENOG4105DFE	Dna adenine methylase
HPK20_RS13430	ENOG4105D49	3-dehydroquinate synthase
HPK20_RS13435	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HPK20_RS13440	ENOG4105E4G	Type IV pilus
HPK20_RS13465	ENOG4108JQC	penicillin-binding protein 1A
HPK20_RS13470	ENOG4105C5Q	Transcriptional regulator
HPK20_RS13475	ENOG4105EHV	domain protein
HPK20_RS13485	ENOG4105CH7	arginosuccinase
HPK20_RS13495	ENOG4105CAS	nag kinase
HPK20_RS13500	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HPK20_RS13505	ENOG4105CWC	Acetylornithine deacetylase
HPK20_RS13510	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HPK20_RS13515	ENOG4105U3E	Transcriptional regulator
HPK20_RS13520	ENOG4105D7W	serine acetyltransferase
HPK20_RS13525	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HPK20_RS13530	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HPK20_RS13535	ENOG4107YZP	Rhodanese domain protein
HPK20_RS13540	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HPK20_RS13550	ENOG4105E33	succinate dehydrogenase
HPK20_RS13555	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HPK20_RS13565	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPK20_RS13570	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HPK20_RS13575	ENOG4105KT7	mgtC SapB transporter
HPK20_RS13585	ENOG4105DKW	ABC transporter
HPK20_RS13590	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPK20_RS13620	ENOG4105CP7	Triose-phosphate isomerase
HPK20_RS13630	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPK20_RS13635	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HPK20_RS13640	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HPK20_RS13645	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HPK20_RS13655	ENOG4105ETE	Transcriptional regulator (LacI family
HPK20_RS13660	ENOG4105C25	Primosomal protein n'
HPK20_RS13665	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HPK20_RS13670	ENOG4105C6K	Malic enzyme
HPK20_RS13680	ENOG4105C28	cystathionine
HPK20_RS13685	ENOG4105CFH	Aspartokinase
HPK20_RS13690	ENOG4105SYT	Methylenetetrahydrofolate reductase
HPK20_RS13695	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
HPK20_RS13700	ENOG4105CBT	Fructose-1,6-bisphosphatase
HPK20_RS13705	ENOG4105CTQ	phosphohexokinase
HPK20_RS13710	ENOG41076HS	cation diffusion facilitator family transporter
HPK20_RS13720	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HPK20_RS13725	ENOG4105E0F	Histidine kinase
HPK20_RS13730	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPK20_RS13735	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HPK20_RS13740	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HPK20_RS13745	ENOG4105BZU	Histidine kinase
HPK20_RS13750	ENOG4108IJ0	Aspartate ammonia-lyase
HPK20_RS13755	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPK20_RS13760	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HPK20_RS13765	ENOG4105CEU	Arginine dihydrolase
HPK20_RS13770	ENOG4105C5B	carbamate kinase
HPK20_RS13775	ENOG4105DBV	ornithine carbamoyltransferase
HPK20_RS13780	ENOG4105CXT	aspartate transcarbamylase
HPK20_RS13785	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
HPK20_RS13790	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HPK20_RS13795	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HPK20_RS13815	ENOG4107QN1	sodium solute
HPK20_RS13820	ENOG4105EX9	Membrane
HPK20_RS13825	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HPK20_RS13835	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPK20_RS13840	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HPK20_RS13845	ENOG4105CB5	ATP-dependent DNA helicase recG
HPK20_RS13850	ENOG4105C2W	permease
HPK20_RS13855	ENOG4105E0F	Histidine kinase
HPK20_RS13865	ENOG4108UHU	Aldolase
HPK20_RS13870	ENOG4105C6Z	Gluconate
HPK20_RS13875	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HPK20_RS13880	ENOG4105C01	Dihydroxy-acid dehydratase
HPK20_RS13885	ENOG4105DIQ	Transcriptional regulator
HPK20_RS13890	ENOG4108RRZ	Transcription elongation factor GreB
HPK20_RS13900	ENOG4105BZM	domain protein
HPK20_RS13910	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPK20_RS13915	ENOG4105MJ2	Competence protein
HPK20_RS13925	ENOG4107RK2	ADP-ribose diphosphatase NudE
HPK20_RS13930	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HPK20_RS13935	ENOG4105PIC	general secretion pathway protein N
HPK20_RS13940	ENOG4105U1E	general secretion pathway protein M
HPK20_RS13945	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HPK20_RS13950	ENOG4108RTD	type II secretion system protein K
HPK20_RS13955	ENOG4108WWZ	General secretion pathway protein J
HPK20_RS13960	ENOG4105X5Z	General secretion pathway protein I
HPK20_RS13965	ENOG4105VWV	general secretion pathway protein h
HPK20_RS13970	ENOG4108VAU	general secretion pathway protein G
HPK20_RS13975	ENOG4105D7Q	type ii secretion system
HPK20_RS13980	ENOG4107QHF	type ii secretion system protein e
HPK20_RS13990	ENOG4108XKW	General secretion pathway protein C
HPK20_RS13995	ENOG4105VEJ	Heat shock protein
HPK20_RS14000	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HPK20_RS14005	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HPK20_RS14010	ENOG4105JV1	AsmA family
HPK20_RS14015	ENOG4105SUU	thioesterase domain
HPK20_RS14020	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HPK20_RS14025	ENOG4107S2Z	UPF0761 membrane protein
HPK20_RS14040	ENOG4105CI3	gtp-binding protein typa
HPK20_RS14045	ENOG4105C5F	glutamine synthetase
HPK20_RS14055	ENOG4105CUX	Signal transduction histidine kinase
HPK20_RS14060	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPK20_RS14065	ENOG4105BZU	Histidine kinase
HPK20_RS14070	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HPK20_RS14130	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HPK20_RS14140	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPK20_RS14165	ENOG4107R73	Mate efflux family protein
HPK20_RS14175	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HPK20_RS14180	ENOG41080IJ	Diacylglycerol kinase
HPK20_RS14185	ENOG4105E55	glycerol-3-phosphate acyltransferase
HPK20_RS14190	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HPK20_RS14195	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HPK20_RS14200	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPK20_RS14205	ENOG4105EBW	Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity)
HPK20_RS14215	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPK20_RS14220	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HPK20_RS14225	ENOG4105CAK	Cell division ATP-binding protein ftsE
HPK20_RS14230	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPK20_RS14235	ENOG4106H78	methyltransferase
HPK20_RS14245	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
HPK20_RS14275	ENOG4108RMU	ferritin dps family protein
HPK20_RS14290	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPK20_RS14295	ENOG41082YX	Transcriptional regulator, arsr family
HPK20_RS14300	ENOG4105D58	Diguanylate phosphodiesterase
HPK20_RS14305	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPK20_RS14310	ENOG4108EUD	Lysophospholipase
HPK20_RS14315	ENOG4105DQF	Hydrolase
HPK20_RS14330	ENOG4106IUH	DTW domain containing protein
HPK20_RS14335	ENOG4105BZU	Histidine kinase
HPK20_RS14340	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HPK20_RS14345	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPK20_RS14350	ENOG4105CT0	Protein of unknown function, DUF484
HPK20_RS14355	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HPK20_RS14360	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HPK20_RS14375	ENOG4107T0K	Adenylate cyclase
HPK20_RS14380	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HPK20_RS14385	ENOG41076E6	Uroporphyrinogen-III Synthase
HPK20_RS14390	ENOG4105ECF	c-methyltransferase
HPK20_RS14395	ENOG410601J	HemY protein
HPK20_RS14400	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPK20_RS14405	ENOG4105XCT	Protein of unknown function (DUF2489)
HPK20_RS14410	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HPK20_RS14420	ENOG4106RE7	Cytochrome
HPK20_RS14430	ENOG4105C2M	dna polymerase I
HPK20_RS14440	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPK20_RS14445	ENOG4105F8V	Hydrolase, tatD family
HPK20_RS14450	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HPK20_RS14455	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HPK20_RS14460	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPK20_RS14465	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HPK20_RS14470	ENOG4105JC1	sterol-binding domain protein
HPK20_RS14475	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPK20_RS14480	ENOG4105CGY	Dna recombination protein
HPK20_RS14505	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
HPK20_RS14510	ENOG4107R0P	L-ribulose-5-phosphate 4-epimerase
HPK20_RS14515	ENOG4105EF1	ribulokinase
HPK20_RS14520	ENOG4105DMK	Periplasmic binding protein LacI transcriptional regulator
HPK20_RS14525	ENOG4105C2J	ABC transporter
HPK20_RS14530	ENOG4105CNN	ABC, transporter
HPK20_RS14535	ENOG4105CBX	hi0933 family
HPK20_RS14540	ENOG4108V6B	universal stress protein B
HPK20_RS14545	ENOG41090A1	ferritin
HPK20_RS14550	ENOG4108M6U	Universal stress protein A
HPK20_RS14555	ENOG4105EMK	carboxylate amino acid amine transporter
HPK20_RS14570	ENOG4105BZU	Histidine kinase
HPK20_RS14575	ENOG4108VVK	transcriptional Regulator, AsnC
HPK20_RS14595	ENOG4105DC7	peptidase M24
HPK20_RS14595	ENOG4105DC7	peptidase M24
HPK20_RS14600	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
HPK20_RS14605	ENOG4105C26	Dehydrogenase
HPK20_RS14610	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
HPK20_RS14625	ENOG4108IJ7	Glycine betaine
HPK20_RS14630	ENOG4105D41	biosynthesis protein thiH
HPK20_RS14635	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HPK20_RS14640	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HPK20_RS14645	ENOG4105D06	uba thif-type nad fad binding protein
HPK20_RS14650	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HPK20_RS14655	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HPK20_RS14660	ENOG4105WMR	Protein CrcB homolog
HPK20_RS14665	ENOG4105E3B	Multicopper oxidase
HPK20_RS14715	ENOG4108RR8	protoporphyrinogen oxidase
HPK20_RS14720	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPK20_RS14725	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HPK20_RS14730	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPK20_RS14735	ENOG4105CHU	acetyl-coa acetyltransferase
HPK20_RS14740	ENOG4105F52	Transcriptional regulator
HPK20_RS14745	ENOG4105CZQ	inner membrane transport protein YdhC
HPK20_RS14755	ENOG4105EAD	ABC transporter
HPK20_RS14760	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPK20_RS14765	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HPK20_RS14770	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPK20_RS14775	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPK20_RS14785	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPK20_RS14790	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPK20_RS14795	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPK20_RS14805	ENOG410684E	atp synthase
HPK20_RS14810	ENOG4105FA0	parb-like partition protein
HPK20_RS14815	ENOG4107QJE	Chromosome Partitioning Protein
HPK20_RS14820	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HPK20_RS14825	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HPK20_RS14830	ENOG4105QTB	Flavodoxin
HPK20_RS14835	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HPK20_RS14840	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPK20_RS14850	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HPK20_RS14865	ENOG4105E5Q	amino acid AbC transporter
HPK20_RS14870	ENOG4105EAB	amino acid AbC transporter
HPK20_RS14975	ENOG4105CMR	udp-glucose 4-epimerase
HPK20_RS14980	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HPK20_RS14985	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HPK20_RS14990	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HPK20_RS14995	ENOG41060NJ	transcriptional regulator
HPK20_RS15020	ENOG4105C6F	GntR Family Transcriptional Regulator
HPK20_RS15025	ENOG4105XEP	YhcH YjgK YiaL family protein
HPK20_RS15035	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS15040	ENOG4105DG4	malate L-lactate dehydrogenase
HPK20_RS15045	ENOG4105CPQ	Dehydrogenase
HPK20_RS15050	ENOG4105DEI	Mannitol dehydrogenase
HPK20_RS15060	ENOG4108UHU	Aldolase
HPK20_RS15065	ENOG4105DIA	mandelate racemase muconate lactonizing
HPK20_RS15080	ENOG4107QI1	Mate efflux family protein
HPK20_RS15095	ENOG4108KPW	sugar kinase
HPK20_RS15105	ENOG4107RUZ	Sss sodium solute transporter superfamily
HPK20_RS15125	ENOG4108N3Q	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HPK20_RS15160	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HPK20_RS15175	ENOG4105C6F	GntR Family Transcriptional Regulator
HPK20_RS15180	ENOG4105C26	Dehydrogenase
HPK20_RS15200	ENOG4105EQR	Transposase IS116 IS110 IS902
HPK20_RS15215	ENOG4105CNT	hydrolase family 2
HPK20_RS15225	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HPK20_RS15245	ENOG4107RUZ	Sss sodium solute transporter superfamily
HPK20_RS15255	ENOG4105ETE	Transcriptional regulator (LacI family
HPK20_RS15260	ENOG4105EIP	mannose-6-phosphate isomerase
HPK20_RS15265	ENOG4105BZW	Glycerate kinase
HPK20_RS15270	ENOG4105C8I	hydrolase, family 38
HPK20_RS15275	ENOG4105DM4	PTS System
HPK20_RS15280	ENOG4105FDP	GntR family transcriptional regulator
HPK20_RS15295	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HPK20_RS15300	ENOG4105DCT	glycerol dehydrogenase
HPK20_RS15400	ENOG4105VZ1	Replication Protein
HPK20_RS15475	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPK20_RS15480	ENOG41090HJ	UPF0265 protein
HPK20_RS15490	ENOG4108YXG	UPF0502 protein
HPK20_RS15495	ENOG41082IR	Excinuclease ABC C subunit domain protein
HPK20_RS15505	ENOG4108QGH	periplasmic
HPK20_RS15510	ENOG4105BZU	Histidine kinase
HPK20_RS15530	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HPK20_RS15535	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HPK20_RS15540	ENOG4105E0C	molybdate abc transporter
HPK20_RS15545	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS15565	ENOG4105EM2	membrane
HPK20_RS15570	ENOG4108JJA	ABC, transporter
HPK20_RS15585	ENOG4107QZV	Type I secretion membrane fusion protein
HPK20_RS15590	ENOG4105CDV	Ompa motb domain protein
HPK20_RS15705	ENOG41088T4	Helicase IV
HPK20_RS15710	ENOG4108RWI	nicotinamidase
HPK20_RS15715	ENOG4108Z5K	methylglyoxal synthase
HPK20_RS15720	ENOG4108SV3	Tmao reductase system periplasmic protein tort
HPK20_RS15725	ENOG4105BZU	Histidine kinase
HPK20_RS15730	ENOG4105CA9	Pyruvate kinase
HPK20_RS15735	ENOG4105CXY	transporter
HPK20_RS15740	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
HPK20_RS15750	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
HPK20_RS15760	ENOG4108I6A	alcohol dehydrogenase
HPK20_RS15765	ENOG4105CF7	AraC family transcriptional regulator
HPK20_RS15780	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPK20_RS15785	ENOG4105BZU	Histidine kinase
HPK20_RS15805	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPK20_RS15810	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPK20_RS15820	ENOG4105CHU	acetyl-coa acetyltransferase
HPK20_RS15830	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HPK20_RS15860	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPK20_RS15875	ENOG4105BZU	Histidine kinase
HPK20_RS15880	ENOG4105WH1	Two component transcriptional regulator luxr family
HPK20_RS15885	ENOG4105CEE	C4-dicarboxylate transporter
HPK20_RS15900	ENOG4105DXI	Major Facilitator superfamily
HPK20_RS15910	ENOG4108N3W	hemolysin secretion protein
HPK20_RS15915	ENOG4107VXZ	Hydrolase
HPK20_RS15920	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPK20_RS15930	ENOG4105CDV	Ompa motb domain protein
HPK20_RS15935	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HPK20_RS15940	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPK20_RS15945	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HPK20_RS15955	ENOG4105KHC	sulfurtransferase
HPK20_RS15960	ENOG4105D06	uba thif-type nad fad binding protein
HPK20_RS15965	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPK20_RS15975	ENOG4105CUB	amino acid
HPK20_RS15985	ENOG4105CPD	ethanolamine ammonia-lyase
HPK20_RS15990	ENOG4108K3Z	AraC family transcriptional regulator
HPK20_RS15995	ENOG4105E0X	reductase
HPK20_RS16000	ENOG4105CKU	formyltetrahydrofolate synthetase
HPK20_RS16005	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HPK20_RS16015	ENOG4105JQN	Transcriptional regulator
HPK20_RS16020	ENOG4105PAD	Hydrolase
HPK20_RS16025	ENOG4105NXH	GreA GreB family elongation factor
HPK20_RS16035	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HPK20_RS16040	ENOG4108JPW	Aminotransferase
HPK20_RS16060	ENOG4107RCV	ABC transporter, permease
HPK20_RS16100	ENOG4105E43	Extracellular solute-binding protein, family 5
HPK20_RS16105	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HPK20_RS16110	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HPK20_RS16115	ENOG4108JQ5	ABC transporter
HPK20_RS16120	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPK20_RS16135	ENOG4105BZU	Histidine kinase
HPK20_RS16145	ENOG4108Q9V	regulatoR
HPK20_RS16150	ENOG4105BZU	Histidine kinase
HPK20_RS16165	ENOG4105WQ3	Rna-binding protein
HPK20_RS16170	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPK20_RS16185	ENOG4105F2V	VRR-NUC domain-containing protein
HPK20_RS16230	ENOG4107QW4	alcohol dehydrogenase
HPK20_RS16235	ENOG4105CF7	AraC family transcriptional regulator
HPK20_RS16255	ENOG4105C87	Aminotransferase class I and II
HPK20_RS16265	ENOG4105C5H	ABC transporter
HPK20_RS16270	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
HPK20_RS16280	ENOG4108EKE	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity)
HPK20_RS16285	ENOG4105CBK	multidrug resistance protein
HPK20_RS16300	ENOG4105ENX	hydrolase
HPK20_RS16305	ENOG4108TU9	TRANSCRIPTIONal
HPK20_RS16335	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPK20_RS16345	ENOG4108F19	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPK20_RS16350	ENOG4105C2W	permease
HPK20_RS16360	ENOG410633P	Hydantoin racemase
HPK20_RS16370	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HPK20_RS16380	ENOG4105DRP	amino acid AbC transporter
HPK20_RS16385	ENOG4105E5Q	amino acid AbC transporter
HPK20_RS16400	ENOG4105DHU	Bile acid
HPK20_RS16410	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPK20_RS16415	ENOG4105C5R	Aminotransferase
HPK20_RS16440	ENOG4107QUY	Guanine deaminase
HPK20_RS16445	ENOG4105VT2	5-hydroxyisourate hydrolase
HPK20_RS16480	ENOG4105UIB	(ABC) transporter
HPK20_RS16485	ENOG4105C2J	ABC transporter
HPK20_RS16490	ENOG4108R86	Transcriptional regulator
HPK20_RS16500	ENOG4105BZU	Histidine kinase
HPK20_RS16525	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPK20_RS16530	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPK20_RS16540	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HPK20_RS16620	ENOG4108ZJT	translation initiation factor, Sui1
HPK20_RS16645	ENOG4105CD5	CoA-binding domain protein
HPK20_RS16650	ENOG4105CWB	LysR family transcriptional Regulator
HPK20_RS16675	ENOG4105KA0	thioesterase Superfamily protein
HPK20_RS16680	ENOG4105D0M	Protease HtpX homolog
HPK20_RS16685	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HPK20_RS16695	ENOG4105DU1	integral membrane protein, terc
HPK20_RS16700	ENOG4105CGH	5'-nucleotidase
HPK20_RS16705	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
HPK20_RS16710	ENOG4108UQ5	membrane protein YcdZ
HPK20_RS16715	ENOG4105DUM	transcriptional regulator, lysR family
HPK20_RS16720	ENOG4105TMB	Formate nitrite transporter
HPK20_RS16725	ENOG4108YYC	ycei family
HPK20_RS16730	ENOG4105DS1	cytochrome b561
HPK20_RS16755	ENOG4105BZU	Histidine kinase
HPK20_RS16765	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
HPK20_RS16770	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPK20_RS16780	ENOG4105BZU	Histidine kinase
HPK20_RS16785	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPK20_RS16795	ENOG4105R1U	AraC Family Transcriptional Regulator
HPK20_RS16800	ENOG4105DFP	Integrase
HPK20_RS16805	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS16835	ENOG41061ZR	Transcriptional regulator
HPK20_RS16850	ENOG41076YT	nitrate reductase, gamma subunit
HPK20_RS16855	ENOG4105R3A	Nitrate reductase
HPK20_RS16860	ENOG4108IUE	nitrate reductase beta subunit
HPK20_RS16865	ENOG4105CRU	nitrate reductase, alpha subunit
HPK20_RS16870	ENOG4105DQQ	Major facilitator superfamily MFS_1
HPK20_RS16875	ENOG4105BZU	Histidine kinase
HPK20_RS16880	ENOG4105WH1	Two component transcriptional regulator luxr family
HPK20_RS16885	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
HPK20_RS16890	ENOG4105CJW	magnesium transporter
HPK20_RS16895	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS16915	ENOG4108JUA	Transcriptional regulator
HPK20_RS16935	ENOG4105ENG	CRISPR-associated protein, Csy1 family
HPK20_RS16945	ENOG4107SV5	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HPK20_RS16960	ENOG4105ECQ	AraC Family Transcriptional Regulator
HPK20_RS16970	ENOG4108YGG	dna repair protein
HPK20_RS17000	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPK20_RS17015	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPK20_RS17065	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPK20_RS17075	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HPK20_RS17080	ENOG4105CKI	cobalamin synthesis protein
HPK20_RS17095	ENOG4107KBT	8-Amino-7-oxononanoate synthase
HPK20_RS17100	ENOG4108MGY	Histidine kinase
HPK20_RS17105	ENOG4105EYH	Exonuclease
HPK20_RS17115	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HPK20_RS17120	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HPK20_RS17125	ENOG4105DE4	1-phosphofructokinase
HPK20_RS17130	ENOG4105DM4	PTS System
HPK20_RS17135	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPK20_RS17140	ENOG4105CGF	Aromatic amino acid aminotransferase
HPK20_RS17145	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HPK20_RS17150	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HPK20_RS17210	ENOG4105N14	lysine exporter protein LysE YggA
HPK20_RS17215	ENOG4108KXV	response regulator
HPK20_RS17225	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HPK20_RS17235	ENOG4108WAV	Transcriptional regulator
HPK20_RS17250	ENOG4105J7D	transcriptional regulator
HPK20_RS17255	ENOG4108M3J	Dehydrogenase
HPK20_RS17270	ENOG4108VP3	Lysine exporter protein (LysE YggA)
HPK20_RS17285	ENOG4108RWI	nicotinamidase
HPK20_RS17295	ENOG4105KD7	acetyltransferase
HPK20_RS17305	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPK20_RS17310	ENOG4105M6F	mutator MutT protein
HPK20_RS17315	ENOG4105RA2	Membrane
HPK20_RS17320	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPK20_RS17335	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPK20_RS17350	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HPK20_RS17355	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPK20_RS17370	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HPK20_RS17380	ENOG4105I4A	GCN5-related N-acetyltransferase
HPK20_RS17415	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HPK20_RS17430	ENOG4108594	Permease of the drug metabolite transporter
HPK20_RS17440	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
HPK20_RS17445	ENOG4105VUF	Transcriptional regulator
HPK20_RS17505	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HPK20_RS17515	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPK20_RS17535	ENOG4105EKT	)-iron permease
HPK20_RS17540	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HPK20_RS17545	ENOG41082NX	50s ribosomal protein l35
HPK20_RS17550	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HPK20_RS17555	ENOG4105C22	threonyL-tRNA synthetase
HPK20_RS17560	ENOG4105C1J	atp-dependent rna helicase
HPK20_RS17575	ENOG4105CVA	phosphate
HPK20_RS17585	ENOG4105DUM	transcriptional regulator, lysR family
HPK20_RS17590	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPK20_RS17600	ENOG4105DM4	PTS System
HPK20_RS17605	ENOG4108YRF	PTS System
HPK20_RS17615	ENOG4106R3P	AraC family transcriptional regulator
HPK20_RS17620	ENOG4105DM4	PTS System
HPK20_RS17625	ENOG4105EIP	mannose-6-phosphate isomerase
HPK20_RS17630	ENOG4105DM4	PTS System
HPK20_RS17640	ENOG4105J12	Multidrug resistance protein mdtN
HPK20_RS17655	ENOG4105DFG	type I secretion outer membrane protein
HPK20_RS17680	ENOG4105EUZ	Beta-lactamase domain protein
HPK20_RS17685	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPK20_RS17690	ENOG4105E98	transcriptional regulator DeoR family
HPK20_RS17695	ENOG4108UW5	maltose o-acetyltransferase
HPK20_RS17700	ENOG4105BZU	Histidine kinase
HPK20_RS17710	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
HPK20_RS17715	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPK20_RS17725	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPK20_RS17735	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPK20_RS17740	ENOG4108JQ6	ABC transporter
HPK20_RS17750	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPK20_RS17755	ENOG4105BZU	Histidine kinase
HPK20_RS17785	ENOG4105II7	pyrroline-5-carboxylate reductase
HPK20_RS17790	ENOG4105CH5	extracellular solute-binding protein, family 7
HPK20_RS17800	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPK20_RS17805	ENOG4105CIF	Ornithine Cyclodeaminase
HPK20_RS17815	ENOG4108IA2	Sodium pantothenate symporter
HPK20_RS17820	ENOG4105CC0	LysR family Transcriptional regulator
HPK20_RS17825	ENOG4105CHF	Glutathione S-transferase
HPK20_RS17835	ENOG4108NIW	Leucine export protein LeuE
HPK20_RS17850	ENOG4105CH2	amidohydrolase
HPK20_RS17855	ENOG4108MGI	Transcriptional regulator
HPK20_RS17865	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS17870	ENOG4105EHG	Permease protein
HPK20_RS17880	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPK20_RS17885	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPK20_RS17890	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
HPK20_RS17895	ENOG4105D2H	Uronic isomerase
HPK20_RS17900	ENOG4107QZW	Altronate oxidoreductase
HPK20_RS17905	ENOG4105CTX	dehydratase
HPK20_RS17945	ENOG4105C10	Electron transfer flavoprotein
HPK20_RS17950	ENOG4105BZJ	Electron transfer flavoprotein
HPK20_RS17955	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HPK20_RS17960	ENOG4105CYM	Glutathione S-transferase
HPK20_RS17980	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS17985	ENOG4105E2Z	phosphate ABC transporter (Permease
HPK20_RS17990	ENOG4105C8U	phosphate abc transporter
HPK20_RS17995	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
HPK20_RS18015	ENOG4105D01	(LipO)protein
HPK20_RS18040	ENOG4105CH5	extracellular solute-binding protein, family 7
HPK20_RS18050	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPK20_RS18055	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPK20_RS18075	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPK20_RS18085	ENOG4105CHR	reductase
HPK20_RS18090	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
HPK20_RS18095	ENOG4105CHR	reductase
HPK20_RS18100	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPK20_RS18105	ENOG4105E39	Enoyl-CoA hydratase
HPK20_RS18110	ENOG4105E39	Enoyl-CoA hydratase
HPK20_RS18115	ENOG4105C1G	acyl-Coa dehydrogenase
HPK20_RS18120	ENOG4105C26	Dehydrogenase
HPK20_RS18125	ENOG4105CHU	acetyl-coa acetyltransferase
HPK20_RS18135	ENOG4105C1G	acyl-Coa dehydrogenase
HPK20_RS18140	ENOG4107QX3	carboxylase
HPK20_RS18145	ENOG4108IPT	Naphthoate synthase
HPK20_RS18150	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
HPK20_RS18160	ENOG4105D3R	alkyl hydroperoxide reductase
HPK20_RS18165	ENOG4108JU3	Alkyl hydroperoxide reductase
HPK20_RS18170	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HPK20_RS18195	ENOG4105T16	Transcriptional regulator (AraC family)
HPK20_RS18200	ENOG4105C0A	alcohol dehydrogenase
HPK20_RS18205	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPK20_RS18220	ENOG4105CVJ	phosphoglycerate mutase
HPK20_RS18245	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPK20_RS18260	ENOG4105T16	Transcriptional regulator (AraC family)
HPK20_RS18265	ENOG4108IPW	abc transporter atp-binding protein
HPK20_RS18270	ENOG4105CM4	permease protein
HPK20_RS18275	ENOG4105DHS	permease protein
HPK20_RS18305	ENOG4107IFA	Lipase (EC 3.1.1.3)
HPK20_RS18310	ENOG4108NVR	Methyl-accepting chemotaxis
HPK20_RS18315	ENOG4108XM1	transcriptional regulator AsnC family
HPK20_RS18335	ENOG4105E5M	Multidrug resistance protein D
HPK20_RS18345	ENOG4108N3W	hemolysin secretion protein
HPK20_RS18365	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPK20_RS18370	ENOG4108VAC	response regulator
HPK20_RS18375	ENOG4108HRK	Histidine kinase
HPK20_RS18380	ENOG4107RGM	aldo keto reductase
HPK20_RS18395	ENOG4107T9C	Alpha amylase catalytic region
HPK20_RS18400	ENOG4105D4Y	metalloprotease
HPK20_RS18405	ENOG4105EIF	outer membrane protein W
HPK20_RS18410	ENOG4106943	Heat shock protein
HPK20_RS18425	ENOG4105KME	endoribonuclease L-psp
HPK20_RS18450	ENOG4105BZ1	(ABC) transporter
HPK20_RS18455	ENOG4105BZ1	(ABC) transporter
HPK20_RS18465	ENOG41066DG	(EAL) domain protein
HPK20_RS18470	ENOG4105IHM	Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity)
HPK20_RS18485	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HPK20_RS18495	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPK20_RS18505	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPK20_RS18510	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPK20_RS18550	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPK20_RS18560	ENOG41089BK	Glutamine amido-transferase
HPK20_RS18570	ENOG4105CPQ	Dehydrogenase
HPK20_RS18575	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPK20_RS18580	ENOG4105C26	Dehydrogenase
HPK20_RS18585	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HPK20_RS18590	ENOG4105EXG	Transcriptional regulator
HPK20_RS18595	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HPK20_RS18615	ENOG4107SSZ	Phosphatase
HPK20_RS18625	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPK20_RS18630	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HPK20_RS18635	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HPK20_RS18640	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPK20_RS18655	ENOG4105CC0	LysR family Transcriptional regulator
HPK20_RS18670	ENOG4105C3R	Methionine synthase
HPK20_RS18675	ENOG4105D5Q	Arginine ornithine antiporter
HPK20_RS18690	ENOG4105CH2	amidohydrolase
HPK20_RS18695	ENOG4105CFC	Transporter
HPK20_RS18700	ENOG4105BZW	Glycerate kinase
HPK20_RS18705	ENOG4105C6Z	Gluconate
HPK20_RS18710	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HPK20_RS18715	ENOG4105C5I	Dehydrogenase
HPK20_RS18720	ENOG4105KNR	Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity)
HPK20_RS18735	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS18750	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS18760	ENOG4105KME	endoribonuclease L-psp
HPK20_RS18835	ENOG4105D6J	arsenicaL-resistance protein
HPK20_RS18850	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPK20_RS18860	ENOG4105C5I	Dehydrogenase
HPK20_RS18865	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HPK20_RS18875	ENOG4108STX	response regulator
HPK20_RS18900	ENOG4105VEQ	Cold shock protein
HPK20_RS18905	ENOG4108VWS	Yaeq family
HPK20_RS18910	ENOG4105BZU	Histidine kinase
HPK20_RS18915	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPK20_RS18920	ENOG4108JUA	Transcriptional regulator
HPK20_RS18930	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPK20_RS18935	ENOG4105D9N	nucleoside
HPK20_RS18960	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS18965	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPK20_RS18985	ENOG4107QVM	von Willebrand factor, type A
HPK20_RS19010	ENOG4105BZU	Histidine kinase
HPK20_RS19025	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
HPK20_RS19030	ENOG4105C26	Dehydrogenase
HPK20_RS19040	ENOG4108T2Z	Arginine
HPK20_RS19050	ENOG4105ECQ	AraC Family Transcriptional Regulator
HPK20_RS19055	ENOG4107S8C	mandelate racemase muconate lactonizing
HPK20_RS19080	ENOG4105DUM	transcriptional regulator, lysR family
HPK20_RS19105	ENOG41090ED	Protein with unknown function (DUF469)
HPK20_RS19110	ENOG4108M6U	Universal stress protein A
HPK20_RS19115	ENOG4108YZN	class I peptide chain release factor
HPK20_RS19120	ENOG4105VRT	cytoplasmic protein
HPK20_RS19130	ENOG4105D5U	fad dependent oxidoreductase
HPK20_RS19150	ENOG4105EIP	mannose-6-phosphate isomerase
HPK20_RS19155	ENOG4105BZW	Glycerate kinase
HPK20_RS19160	ENOG4105C8I	hydrolase, family 38
HPK20_RS19165	ENOG4105DM4	PTS System
HPK20_RS19170	ENOG4105FDP	GntR family transcriptional regulator
HPK20_RS19175	ENOG4105CQZ	Histidine kinase
HPK20_RS19195	ENOG4105BZU	Histidine kinase
HPK20_RS19200	ENOG4105CXY	transporter
HPK20_RS19205	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HPK20_RS19210	ENOG4107U5R	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
HPK20_RS19215	ENOG4105DND	Transcriptional regulator
HPK20_RS19220	ENOG4105ETE	Transcriptional regulator (LacI family
HPK20_RS19225	ENOG4108RVA	ribokinase
HPK20_RS19230	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HPK20_RS19235	ENOG4105CNN	ABC, transporter
HPK20_RS19240	ENOG4105C2J	ABC transporter
HPK20_RS19245	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HPK20_RS19285	ENOG4108JUB	Transcriptional regulator
HPK20_RS19290	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPK20_RS19350	ENOG4105EW9	transcriptional regulator AsnC family
HPK20_RS19355	ENOG4108VP3	Lysine exporter protein (LysE YggA)
HPK20_RS19360	ENOG4108ZT1	Transcriptional regulator
HPK20_RS19375	ENOG4105D3G	Pseudouridine synthase
HPK20_RS19380	ENOG4108WUH	Transcriptional regulator, TetR family
HPK20_RS19385	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HPK20_RS19400	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HPK20_RS19410	ENOG4105CY5	solute-binding protein
HPK20_RS19420	ENOG4105D38	putrescine abc transporter
HPK20_RS19430	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS19440	ENOG4105BZU	Histidine kinase
HPK20_RS19445	ENOG4105CV8	reductase
HPK20_RS19450	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPK20_RS19455	ENOG4105HEI	LysR family (Transcriptional regulator
HPK20_RS19460	ENOG4105F27	Major Facilitator
HPK20_RS19480	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HPK20_RS19505	ENOG41090KN	UPF0303 protein
HPK20_RS19510	ENOG4105D9R	oxidoreductase
HPK20_RS19515	ENOG4105E98	transcriptional regulator DeoR family
HPK20_RS19520	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HPK20_RS19535	ENOG4106M3D	hemolysin
HPK20_RS19540	ENOG4105KUU	lipolytic protein G-D-S-L family
HPK20_RS19560	ENOG4105E0A	ABC, transporter
HPK20_RS19565	ENOG4108IHU	transport system permease protein
HPK20_RS19570	ENOG4105DQ5	transport system permease protein
HPK20_RS19575	ENOG4108HUF	Transporter
HPK20_RS19580	ENOG4108ESX	Receptor
HPK20_RS19605	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS19610	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HPK20_RS19615	ENOG4105CC0	LysR family Transcriptional regulator
HPK20_RS19625	ENOG4105VYW	UPF0251 protein
HPK20_RS19630	ENOG4108DBC	nitroreductase
HPK20_RS19640	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPK20_RS19645	ENOG4105E89	ABC transporter
HPK20_RS19650	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPK20_RS19655	ENOG4105VW4	glutaredoxin 3
HPK20_RS19665	ENOG4105E5M	Multidrug resistance protein D
HPK20_RS19670	ENOG4105EQ2	LysR family Transcriptional regulator
HPK20_RS19675	ENOG4105BZU	Histidine kinase
HPK20_RS19680	ENOG4105DR5	peptidase
HPK20_RS19695	ENOG4105CHH	sulfate transporter
HPK20_RS19700	ENOG4105DWD	nucleoside recognition domain protein
HPK20_RS19710	ENOG4108KHX	Diguanylate cyclase
HPK20_RS19720	ENOG4105E2Z	phosphate ABC transporter (Permease
HPK20_RS19725	ENOG4105C8U	phosphate abc transporter
HPK20_RS19730	ENOG4105CVA	phosphate
HPK20_RS19735	ENOG4108N3W	hemolysin secretion protein
HPK20_RS19740	ENOG4105C1J	atp-dependent rna helicase
HPK20_RS19750	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HPK20_RS19755	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPK20_RS19765	ENOG4107SEY	Conserved Protein
HPK20_RS19770	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPK20_RS19785	ENOG4106TD9	Diguanylate cyclase
HPK20_RS19790	ENOG4105KK7	inner membrane protein YiaW
HPK20_RS19795	ENOG4105EFX	secretion protein, HlyD family
HPK20_RS19825	ENOG4105YE1	PilZ domain
HPK20_RS19830	ENOG4105D6U	Sodium Glutamate Symporter
HPK20_RS19855	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPK20_RS19860	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HPK20_RS19870	ENOG4107W52	maltose operon periplasmic protein
HPK20_RS19875	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HPK20_RS19895	ENOG4105BZ1	(ABC) transporter
HPK20_RS19905	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
HPK20_RS19915	ENOG4108IEG	Formate dehydrogenase Alpha subunit
HPK20_RS19930	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS19940	ENOG4105CZV	ABC transporter
HPK20_RS19945	ENOG4105FDP	GntR family transcriptional regulator
HPK20_RS19955	ENOG4105C0F	tryptophanase EC 4.1.99.1
HPK20_RS19960	ENOG4108Q67	UPF0319 protein
HPK20_RS19965	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPK20_RS19975	ENOG4105C8P	)-transporter
HPK20_RS20020	ENOG4105CS6	Rhs element vgr protein
HPK20_RS20025	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPK20_RS20030	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HPK20_RS20035	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HPK20_RS20040	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HPK20_RS20045	ENOG41061ZR	Transcriptional regulator
HPK20_RS20050	ENOG4108YYI	Protein of unknown function (DUF2810)
HPK20_RS20055	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HPK20_RS20060	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
HPK20_RS20065	ENOG4105CCU	oxidase (Subunit III)
HPK20_RS20070	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HPK20_RS20075	ENOG4105E2S	oxidase) subunit II
HPK20_RS20085	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS20090	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPK20_RS20095	ENOG4105JQN	Transcriptional regulator
HPK20_RS20105	ENOG4105CDY	transcriptional regulatory protein
HPK20_RS20135	ENOG4106RMF	ParB family
HPK20_RS20140	ENOG4107RUE	extracellular solute-binding protein family 1
HPK20_RS20145	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HPK20_RS20155	ENOG4108VYJ	response regulator receiver protein
HPK20_RS20160	ENOG4105CBS	Chea signal transduction histidine kinase
HPK20_RS20165	ENOG4108V3W	Chemotaxis protein, CheW
HPK20_RS20170	ENOG4108V3W	Chemotaxis protein, CheW
HPK20_RS20175	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS20180	ENOG4105BZU	Histidine kinase
HPK20_RS20185	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
HPK20_RS20195	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS20205	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPK20_RS20215	ENOG4108JJA	ABC, transporter
HPK20_RS20230	ENOG4107QZV	Type I secretion membrane fusion protein
HPK20_RS20245	ENOG4105E6M	Sulphatase-modifying factor protein
HPK20_RS20260	ENOG4105C26	Dehydrogenase
HPK20_RS20270	ENOG4105CK7	Sodium proline symporter
HPK20_RS20280	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS20285	ENOG4105EW9	transcriptional regulator AsnC family
HPK20_RS20290	ENOG4107RGH	Aldehyde dehydrogenase
HPK20_RS20300	ENOG4105C1J	atp-dependent rna helicase
HPK20_RS20310	ENOG4107QXX	ABC transporter
HPK20_RS20315	ENOG4105EZ7	amino acid ABC transporter
HPK20_RS20320	ENOG4105DRP	amino acid AbC transporter
HPK20_RS20325	ENOG4105CDA	abc transporter atp-binding protein
HPK20_RS20330	ENOG4105D44	asparaginase
HPK20_RS20335	ENOG4105VFU	Rna-binding protein
HPK20_RS20340	ENOG4105C9B	Cysteine desulfurase
HPK20_RS20345	ENOG4108ZRZ	Transcriptional regulator (AsnC family)
HPK20_RS20350	ENOG4105C6Z	Gluconate
HPK20_RS20355	ENOG4105EXW	epimerase dehydratase
HPK20_RS20360	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HPK20_RS20365	ENOG4105FB2	class II Aldolase
HPK20_RS20370	ENOG4105G63	Type III effector Hrp-dependent
HPK20_RS20375	ENOG4105ZXK	Dehydrogenase
HPK20_RS20380	ENOG4105MVE	transcriptional regulator
HPK20_RS20385	ENOG4107SDU	Methyl-accepting chemotaxis
HPK20_RS20395	ENOG4105HEI	LysR family (Transcriptional regulator
HPK20_RS20400	ENOG4108RYK	Nad-dependent epimerase dehydratase
HPK20_RS20405	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
HPK20_RS20410	ENOG41063TF	transcriptional regulator (AraC
HPK20_RS20415	ENOG4108W2Y	isochorismatase
HPK20_RS20420	ENOG4105T16	Transcriptional regulator (AraC family)
HPK20_RS20435	ENOG41061CK	Antibiotic biosynthesis monooxygenase
HPK20_RS20440	ENOG410901E	Membrane
HPK20_RS20450	ENOG4107SQD	Transcriptional regulator, GntR family
HPK20_RS20475	ENOG4105N1F	Hnh endonuclease
HPK20_RS20485	ENOG4108ESY	Metal dependent phosphohydrolase
HPK20_RS20490	ENOG4107WZZ	SMC domain protein
HPK20_RS20515	ENOG4105CQR	helicase
HPK20_RS20535	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HPK20_RS20555	ENOG4105R8A	Heat shock protein
HPK20_RS20560	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HPK20_RS20570	ENOG4105C5Q	Transcriptional regulator
HPK20_RS20575	ENOG4105CFC	Transporter
HPK20_RS20580	ENOG4105CH2	amidohydrolase
HPK20_RS20590	ENOG4105EP9	oxidoreductase
HPK20_RS20595	ENOG4105E61	Mannitol repressor protein
HPK20_RS20600	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HPK20_RS20605	ENOG4105CTS	PTS system mannitol-specific
HPK20_RS20610	ENOG4105DR5	peptidase
HPK20_RS20625	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HPK20_RS20650	ENOG4105DZC	cytosine deaminase
HPK20_RS20655	ENOG4108VGI	doxx family
HPK20_RS20660	ENOG4105D03	DNA-3-methyladenine glycosylase II
HPK20_RS20665	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HPK20_RS20675	ENOG4105DN9	Na H antiporter
HPK20_RS20680	ENOG4105CK2	sodium dicarboxylate symporter
HPK20_RS20695	ENOG4105EZV	Transcriptional regulator
HPK20_RS20715	ENOG4105J12	Multidrug resistance protein mdtN
HPK20_RS20730	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HPK20_RS20735	ENOG4105K56	Transcriptional regulator
HPK20_RS20740	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HPK20_RS20760	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPK20_RS20770	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPK20_RS20785	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HPK20_RS20795	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HPK20_RS20820	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HPK20_RS20835	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPK20_RS20865	ENOG4108K2B	transcriptional regulator
HPK20_RS20875	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HPK20_RS20885	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPK20_RS20890	ENOG4108594	Permease of the drug metabolite transporter
HPK20_RS20895	ENOG4108ISG	Major Facilitator
HPK20_RS20900	ENOG4108RXX	maleylacetoacetate isomerase
HPK20_RS20910	ENOG4105VSH	4-oxalocrotonate tautomerase
HPK20_RS20925	ENOG4105CBN	LysR family transcriptional regulator
HPK20_RS20945	ENOG4105KAF	membrAne
HPK20_RS20965	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HPK20_RS20995	ENOG4105DAA	L-lactate
HPK20_RS21000	ENOG4105CC0	LysR family Transcriptional regulator
HPK20_RS21005	ENOG4108JQ5	ABC transporter
HPK20_RS21015	ENOG4105DAN	ATP-dependent protease
HPK20_RS21020	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS21025	ENOG4105E5W	Transporter
HPK20_RS21030	ENOG4105D64	Mechanosensitive ion channel
HPK20_RS21035	ENOG4107ZYR	domain protein
HPK20_RS21050	ENOG4105NBK	UPF0345 protein
HPK20_RS21055	ENOG4105EUB	pirin domain protein
HPK20_RS21065	ENOG4108K0B	C-di-gmp phosphodiesterase
HPK20_RS21090	ENOG4105BZU	Histidine kinase
HPK20_RS21110	ENOG4106TD9	Diguanylate cyclase
HPK20_RS21135	ENOG4105CKW	Inner membrane protein yedI
HPK20_RS21140	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
HPK20_RS21145	ENOG4105EKE	dihydroorotase
HPK20_RS21150	ENOG4105QVC	MOSC domain-containing protein
HPK20_RS21180	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPK20_RS21185	ENOG4105EHG	Permease protein
HPK20_RS21195	ENOG4106GFD	transport protein
HPK20_RS21200	ENOG41090AP	transport protein
HPK20_RS21205	ENOG4105WQ5	TonB family
HPK20_RS21210	ENOG41090JE	Utilization Protein
HPK20_RS21215	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HPK20_RS21220	ENOG4105C8Q	Methyl-accepting chemotaxis
HPK20_RS21225	ENOG4105DVH	amino acid
HPK20_RS21230	ENOG4108XM1	transcriptional regulator AsnC family
HPK20_RS21240	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
HPK20_RS21255	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
HPK20_RS21260	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPK20_RS21265	ENOG4105CXC	rtn protein
HPK20_RS21290	ENOG4105BZU	Histidine kinase
HPK20_RS21295	ENOG4105BZU	Histidine kinase
HPK20_RS21300	ENOG4107YWA	deoxycytidylate deaminase
HPK20_RS21310	ENOG4108UKZ	OsmC family
HPK20_RS21345	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HPK20_RS21375	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPK20_RS21380	ENOG4105DHQ	Histidine kinase
HPK20_RS21390	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPK20_RS21395	ENOG4105MIR	Phenylalanine 4-monooxygenase
HPK20_RS21400	ENOG41090A4	Pterin carbinolamine dehydratase
HPK20_RS21405	ENOG4105UQX	Mate efflux family protein
HPK20_RS21415	ENOG4105EE5	Membrane protein terC
HPK20_RS21425	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPK20_RS21430	ENOG4108JPW	Aminotransferase
HPK20_RS21435	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
HPK20_RS21440	ENOG4105CZK	Aspartate kinase
HPK20_RS21455	ENOG4107R11	Transcriptional regulator
HPK20_RS21465	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPK20_RS21470	ENOG4105BZU	Histidine kinase
HPK20_RS21475	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPK20_RS21485	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPK20_RS21490	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPK20_RS21515	ENOG4105GIJ	Glycine betaine
HPK20_RS21520	ENOG4108HQS	Glycine betaine
HPK20_RS21525	ENOG4108IJ7	Glycine betaine
HPK20_RS21535	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HPK20_RS21550	ENOG4105C28	cystathionine
HPK20_RS21560	ENOG4105E5Q	amino acid AbC transporter
HPK20_RS21570	ENOG4105DZ1	carboxypeptidase
HPK20_RS21585	ENOG4105Y49	secretion protein, HlyD family
HPK20_RS21605	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HPK20_RS21610	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPK20_RS21615	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HPK20_RS21620	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPK20_RS21625	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HPK20_RS21630	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPK20_RS21635	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPK20_RS21640	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HPK20_RS21650	ENOG4107QWG	2-Nitropropane dioxygenase
HPK20_RS21655	ENOG4105N14	lysine exporter protein LysE YggA
HPK20_RS21665	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPK20_RS21690	ENOG4105D0C	transport protein
HPK20_RS21700	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HPK20_RS21720	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPK20_RS21755	ENOG4105VTS	DnaJ-like, subfamily C
HPK20_RS21765	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
HPK20_RS21770	ENOG4105HDD	phospholipase
HPK20_RS21785	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPK20_RS21790	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HPK20_RS21795	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPK20_RS21805	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HPK20_RS21815	ENOG4105BZU	Histidine kinase
HPK20_RS21825	ENOG4107RE1	Inosine-guanosine kinase
HPK20_RS21840	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPK20_RS21860	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPK20_RS21875	ENOG4105RKW	reductase (By
HPK20_RS21885	ENOG4108I0Y	(ABC) transporter
HPK20_RS21890	ENOG4105CV6	ABC transporter, permease
HPK20_RS21900	ENOG4107R7A	Allophanate hydrolase subunit 2
HPK20_RS21910	ENOG4105E7W	lamb ycsf family protein
HPK20_RS21915	ENOG4105BZU	Histidine kinase
HPK20_RS21920	ENOG4105CMR	udp-glucose 4-epimerase
HPK20_RS21925	ENOG4108N3W	hemolysin secretion protein
HPK20_RS21930	ENOG4105E0U	tyrosine-specific transport protein
HPK20_RS21935	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HPK20_RS21940	ENOG4105C1J	atp-dependent rna helicase
HPK20_RS21945	ENOG4107XI7	Tetr family transcriptional regulator
HPK20_RS21950	ENOG4106RE7	Cytochrome
HPK20_RS21955	ENOG4105C5W	Aldolase
HPK20_RS21965	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
HPK20_RS21970	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HPK20_RS22010	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HPK20_RS22020	ENOG4105CKK	Glycosyl transferase, family 2
HPK20_RS22030	ENOG410642W	LysR family Transcriptional regulator
HPK20_RS22035	ENOG4108IPJ	Membrane
HPK20_RS22040	ENOG4106AXJ	AraC family transcriptional regulator
HPK20_RS22065	ENOG4107QX8	SPFH domain, Band 7 family protein
HPK20_RS22075	ENOG4105DEN	Luciferase family
HPK20_RS22090	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPK20_RS22095	ENOG4107RSM	transcriptional regulator
HPK20_RS22100	ENOG4105FFC	UPF0187 protein
HPK20_RS22110	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPK20_RS22115	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPK20_RS22120	ENOG4108UHU	Aldolase
HPK20_RS22125	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
HPK20_RS22135	ENOG4105DEI	Mannitol dehydrogenase
HPK20_RS22145	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPK20_RS22150	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
HPK20_RS22155	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPK20_RS22160	ENOG4107YCY	Transcriptional regulator
HPK20_RS22165	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HPK20_RS22175	ENOG4105DEI	Mannitol dehydrogenase
HPK20_RS22180	ENOG4105CMG	Carbohydrate kinase
HPK20_RS22185	ENOG4105IE8	Alpha-ketoglutarate permease
HPK20_RS22190	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
HPK20_RS22195	ENOG4108RCM	Nitroreductase
HPK20_RS22200	ENOG4105JQN	Transcriptional regulator
HPK20_RS22205	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPK20_RS22210	ENOG4108NVR	Methyl-accepting chemotaxis
HPK20_RS22235	ENOG4105C94	Transporter
HPK20_RS22265	ENOG4107QZF	nitrite reductase NADPH large subunit
HPK20_RS22270	ENOG4105WZK	nitrite reductase NADPH small subunit
HPK20_RS22275	ENOG4105TMB	Formate nitrite transporter
HPK20_RS22280	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPK20_RS22300	ENOG4105VXR	cytoplasmic protein
HPK20_RS22310	ENOG4105K63	Thioredoxin
HPK20_RS22315	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPK20_RS22330	ENOG4105D3Q	Sugar transferase
HPK20_RS22340	ENOG4105DAY	polysaccharide export protein
HPK20_RS22365	ENOG4105CG5	Glycosyl transferase (Group 1
HPK20_RS22370	ENOG4107RA4	Glycosyl transferase (Group 1
HPK20_RS22380	ENOG4105C4C	beta-galactosidase
HPK20_RS22385	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HPK20_RS22390	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
HPK20_RS22395	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HPK20_RS22400	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPK20_RS22405	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HPK20_RS22410	ENOG4106CC8	Bacterial inner membrane protein
HPK20_RS22460	ENOG4105TKZ	Tail Sheath
HPK20_RS22500	ENOG4105ED4	portal protein
HPK20_RS22540	ENOG4105EQR	Transposase IS116 IS110 IS902
HPK20_RS22545	ENOG4105CPC	Aldo Keto reductase
HPK20_RS22550	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPK20_RS22560	ENOG4105ETT	transcriptional Regulator, LysR family
HPK20_RS22565	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
HPK20_RS22580	ENOG4105CHR	reductase
HPK20_RS22585	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)