locus-tag	class	description
HPK20_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPK20_RS00010	COG0592	DNA-directed DNA polymerase activity
HPK20_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPK20_RS00020	COG0187	DNA topoisomerase II activity
HPK20_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
HPK20_RS00030	COG3977	Valine--pyruvate aminotransferase
HPK20_RS00035	COG0751	glycine-tRNA ligase activity
HPK20_RS00040	COG0752	glycyl-tRNA synthetase alpha subunit
HPK20_RS00045	COG2119	membrane
HPK20_RS00055	COG0425	Belongs to the sulfur carrier protein TusA family
HPK20_RS00070	COG0604	alcohol dehydrogenase
HPK20_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPK20_RS00090	COG3978	acetolactate synthase activity
HPK20_RS00100	COG0606	chelatase, subunit chli
HPK20_RS00145	COG0204	Acyl-transferase
HPK20_RS00150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPK20_RS00155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK20_RS00165	COG3084	Protein conserved in bacteria
HPK20_RS00170	COG4326	sporulation control protein
HPK20_RS00175	COG1272	protein, Hemolysin III
HPK20_RS00185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPK20_RS00190	COG0569	domain protein
HPK20_RS00195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPK20_RS00195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPK20_RS00205	COG0242	peptide deformylase activity
HPK20_RS00210	COG1652	LysM domain
HPK20_RS00215	COG0758	DNA mediated transformation
HPK20_RS00220	COG2922	Belongs to the Smg family
HPK20_RS00225	COG0551	DNA topoisomerase type I activity
HPK20_RS00230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPK20_RS00235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPK20_RS00245	COG0408	coproporphyrinogen oxidase activity
HPK20_RS00250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPK20_RS00260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPK20_RS00300	COG0583	DNA-binding transcription factor activity
HPK20_RS00305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPK20_RS00310	COG2960	long-chain fatty acid transporting porin activity
HPK20_RS00315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK20_RS00320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_RS00330	COG0210	DNA helicase
HPK20_RS00370	COG0747	negative chemotaxis
HPK20_RS00380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK20_RS00390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK20_RS00395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_RS00410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPK20_RS00415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPK20_RS00450	COG0210	DNA helicase
HPK20_RS00455	COG0405	Gamma-glutamyltransferase
HPK20_RS00460	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS00470	COG2962	Rard protein
HPK20_RS00475	COG0514	ATP-dependent DNA helicase (RecQ)
HPK20_RS00490	COG1132	(ABC) transporter
HPK20_RS00495	COG1120	ATPase activity
HPK20_RS00500	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPK20_RS00515	COG2862	Uncharacterized protein family, UPF0114
HPK20_RS00520	COG1561	YicC-like family, N-terminal region
HPK20_RS00525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPK20_RS00530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPK20_RS00535	COG1560	Kdo2-lipid A biosynthetic process
HPK20_RS00540	COG1309	transcriptional regulator
HPK20_RS00555	COG2003	Belongs to the UPF0758 family
HPK20_RS00565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPK20_RS00575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPK20_RS00590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPK20_RS00595	COG0438	transferase activity, transferring glycosyl groups
HPK20_RS00600	COG0438	transferase activity, transferring glycosyl groups
HPK20_RS00605	COG0463	Glycosyl transferase, family 2
HPK20_RS00610	COG0859	PFAM glycosyl transferase family 9
HPK20_RS00615	COG3642	lipopolysaccharide core region biosynthetic process
HPK20_RS00620	COG1519	Transferase
HPK20_RS00625	COG0859	PFAM glycosyl transferase family 9
HPK20_RS00640	COG0297	glycogen (starch) synthase activity
HPK20_RS00640	COG0438	transferase activity, transferring glycosyl groups
HPK20_RS00655	COG1560	Kdo2-lipid A biosynthetic process
HPK20_RS00665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPK20_RS00670	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_RS00700	COG3206	protein involved in exopolysaccharide biosynthesis
HPK20_RS00700	COG0489	protein tyrosine kinase activity
HPK20_RS00705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPK20_RS00710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPK20_RS00730	COG2843	Capsule synthesis protein
HPK20_RS00765	COG0582	viral genome integration into host DNA
HPK20_RS00805	COG1482	cell wall glycoprotein biosynthetic process
HPK20_RS00810	COG2271	Major facilitator Superfamily
HPK20_RS00815	COG3851	Histidine kinase
HPK20_RS00820	COG2197	response regulator
HPK20_RS00835	COG1129	ABC transporter
HPK20_RS00840	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPK20_RS00885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPK20_RS00920	COG2843	Capsule synthesis protein
HPK20_RS00930	COG0438	transferase activity, transferring glycosyl groups
HPK20_RS00935	COG0438	transferase activity, transferring glycosyl groups
HPK20_RS00940	COG3562	capsule polysaccharide
HPK20_RS00945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK20_RS00950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPK20_RS00955	COG1573	uracil-dna glycosylase
HPK20_RS00960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_RS00965	COG3068	Protein conserved in bacteria
HPK20_RS00970	COG0668	transmembrane transport
HPK20_RS00975	COG1253	flavin adenine dinucleotide binding
HPK20_RS00980	COG0776	regulation of translation
HPK20_RS00995	COG0151	Belongs to the GarS family
HPK20_RS01000	COG0138	bifunctional purine biosynthesis protein purh
HPK20_RS01010	COG0789	Transcriptional regulator
HPK20_RS01015	COG0840	transmembrane signaling receptor activity
HPK20_RS01020	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPK20_RS01025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPK20_RS01030	COG2264	protein methyltransferase activity
HPK20_RS01035	COG0439	Biotin carboxylase
HPK20_RS01040	COG0511	ligase activity, forming carbon-carbon bonds
HPK20_RS01045	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPK20_RS01050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPK20_RS01065	COG2814	Major facilitator Superfamily
HPK20_RS01070	COG0784	Response regulator, receiver
HPK20_RS01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_RS01070	COG2198	Histidine kinase
HPK20_RS01070	COG2205	protein histidine kinase activity
HPK20_RS01075	COG0248	Ppx GppA phosphatase
HPK20_RS01080	COG0513	Belongs to the DEAD box helicase family
HPK20_RS01085	COG3118	belongs to the thioredoxin family
HPK20_RS01100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPK20_RS01165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPK20_RS01175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPK20_RS01185	COG1072	(Pantothenic acid kinase))
HPK20_RS01215	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPK20_RS01220	COG0250	Participates in transcription elongation, termination and antitermination
HPK20_RS01225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPK20_RS01235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPK20_RS01240	COG0222	ribosome binding
HPK20_RS01245	COG0085	RNA polymerase activity
HPK20_RS01250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPK20_RS01255	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPK20_RS01260	COG2816	NAD+ diphosphatase activity
HPK20_RS01265	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPK20_RS01280	COG4942	peptidase
HPK20_RS01285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPK20_RS01300	COG0490	domain, Protein
HPK20_RS01300	COG0471	metal ion transport
HPK20_RS01305	COG0688	phosphatidylethanolamine metabolic process
HPK20_RS01310	COG1162	GTPase activity
HPK20_RS01365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPK20_RS01370	COG0802	atpase or kinase
HPK20_RS01380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPK20_RS01385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPK20_RS01390	COG1923	regulation of RNA biosynthetic process
HPK20_RS01395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPK20_RS01400	COG0330	HflC and HflK could
HPK20_RS01405	COG0330	HflC and HflK could
HPK20_RS01410	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPK20_RS01415	COG2900	Belongs to the SlyX family
HPK20_RS01425	COG0545	Peptidyl-prolyl cis-trans isomerase
HPK20_RS01430	COG2964	Protein conserved in bacteria
HPK20_RS01435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPK20_RS01440	COG2923	Belongs to the DsrF TusC family
HPK20_RS01445	COG2168	tRNA wobble position uridine thiolation
HPK20_RS01455	COG0049	tRNA binding
HPK20_RS01460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPK20_RS01470	COG2906	2 iron, 2 sulfur cluster binding
HPK20_RS01480	COG0360	Binds together with S18 to 16S ribosomal RNA
HPK20_RS01485	COG2965	DNA replication, synthesis of RNA primer
HPK20_RS01495	COG0359	binds to the 23S rRNA
HPK20_RS01510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPK20_RS01520	COG0166	Belongs to the GPI family
HPK20_RS01530	COG0735	belongs to the Fur family
HPK20_RS01535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPK20_RS01555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPK20_RS01565	COG0175	sulfate reduction
HPK20_RS01635	COG1410	methionine synthase
HPK20_RS01635	COG0646	methionine synthase
HPK20_RS01640	COG0527	aspartate kinase activity
HPK20_RS01645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPK20_RS01655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPK20_RS01670	COG0629	single-stranded DNA binding
HPK20_RS01675	COG2200	EAL domain
HPK20_RS01675	COG2199	diguanylate cyclase activity
HPK20_RS01700	COG3409	Peptidoglycan-binding domain 1 protein
HPK20_RS01700	COG3267	Type II secretory pathway component ExeA
HPK20_RS01710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPK20_RS01760	COG1077	Cell shape determining protein MreB Mrl
HPK20_RS01765	COG1792	Involved in formation and maintenance of cell shape
HPK20_RS01770	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPK20_RS01775	COG0424	maF-like protein
HPK20_RS01780	COG1530	ribonuclease E activity
HPK20_RS01785	COG3164	Protein of unknown function
HPK20_RS01790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK20_RS01795	COG0312	modulator of DNA gyrase
HPK20_RS01815	COG0589	response to stress
HPK20_RS01835	COG0039	L-malate dehydrogenase activity
HPK20_RS01840	COG0531	amino acid
HPK20_RS01845	COG0142	geranyltranstransferase activity
HPK20_RS01850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPK20_RS01860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPK20_RS01865	COG2966	Psort location CytoplasmicMembrane, score
HPK20_RS01870	COG3610	response to peptide
HPK20_RS01880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPK20_RS01885	COG2967	ApaG domain
HPK20_RS01890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPK20_RS01895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPK20_RS01900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPK20_RS01905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPK20_RS01910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPK20_RS01965	COG0741	lytic transglycosylase activity
HPK20_RS01970	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPK20_RS01975	COG1194	a g-specific adenine glycosylase
HPK20_RS01985	COG2066	Belongs to the glutaminase family
HPK20_RS01990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPK20_RS01995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPK20_RS02000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPK20_RS02010	COG1872	DUF167
HPK20_RS02015	COG0762	integral membrane protein
HPK20_RS02020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPK20_RS02025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPK20_RS02040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPK20_RS02045	COG1678	Uncharacterized ACR, COG1678
HPK20_RS02050	COG0189	ligase activity
HPK20_RS02055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPK20_RS02060	COG2356	endonuclease I
HPK20_RS02075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPK20_RS02080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPK20_RS02085	COG0583	DNA-binding transcription factor activity
HPK20_RS02090	COG4771	TonB-dependent receptor
HPK20_RS02095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK20_RS02100	COG0126	phosphoglycerate kinase activity
HPK20_RS02105	COG0191	fructose-bisphosphate aldolase activity
HPK20_RS02110	COG0668	transmembrane transport
HPK20_RS02135	COG3706	GGDEF domain
HPK20_RS02145	COG1349	DNA-binding transcription factor activity
HPK20_RS02150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPK20_RS02155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_RS02170	COG2239	Acts as a magnesium transporter
HPK20_RS02200	COG1610	YqeY-like protein
HPK20_RS02205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPK20_RS02210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPK20_RS02215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPK20_RS02220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPK20_RS02225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPK20_RS02230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPK20_RS02240	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPK20_RS02245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPK20_RS02255	COG0585	pseudouridine synthase activity
HPK20_RS02260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPK20_RS02270	COG4942	peptidase
HPK20_RS02270	COG1388	LysM domain
HPK20_RS02275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPK20_RS02280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPK20_RS02285	COG1546	Belongs to the CinA family
HPK20_RS02290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPK20_RS02300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPK20_RS02305	COG0527	aspartate kinase activity
HPK20_RS02355	COG3630	sodium ion export across plasma membrane
HPK20_RS02360	COG5016	pyruvate
HPK20_RS02360	COG0511	ligase activity, forming carbon-carbon bonds
HPK20_RS02365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPK20_RS02370	COG1063	alcohol dehydrogenase
HPK20_RS02375	COG1238	metal cluster binding
HPK20_RS02380	COG0612	Peptidase, M16
HPK20_RS02395	COG1854	S-ribosylhomocysteine lyase activity
HPK20_RS02400	COG4536	flavin adenine dinucleotide binding
HPK20_RS02405	COG4137	Cytochrome C assembly protein
HPK20_RS02410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPK20_RS02420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPK20_RS02430	COG0335	large ribosomal subunit rRNA binding
HPK20_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK20_RS02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK20_RS02445	COG3105	Protein conserved in bacteria
HPK20_RS02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPK20_RS02455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPK20_RS02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPK20_RS02465	COG0723	plastoquinol--plastocyanin reductase activity
HPK20_RS02470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPK20_RS02475	COG2857	Cytochrome c1
HPK20_RS02480	COG0625	glutathione transferase activity
HPK20_RS02485	COG2969	positive regulation of protein catabolic process
HPK20_RS02490	COG2823	Periplasmic or secreted lipoprotein
HPK20_RS02495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPK20_RS02500	COG0792	nuclease activity
HPK20_RS02505	COG3107	peptidoglycan biosynthetic process
HPK20_RS02510	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPK20_RS02525	COG3116	cell division
HPK20_RS02530	COG0768	penicillin binding
HPK20_RS02535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPK20_RS02540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPK20_RS02550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPK20_RS02555	COG0772	Belongs to the SEDS family
HPK20_RS02560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPK20_RS02565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPK20_RS02570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPK20_RS02575	COG0849	cell division
HPK20_RS02580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPK20_RS02585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPK20_RS02595	COG0653	protein targeting
HPK20_RS02600	COG0494	nUDIX hydrolase
HPK20_RS02610	COG0505	Belongs to the CarA family
HPK20_RS02615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPK20_RS02620	COG0730	response to heat
HPK20_RS02625	COG0583	DNA-binding transcription factor activity
HPK20_RS02645	COG2860	membrane
HPK20_RS02650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK20_RS02670	COG0493	'glutamate synthase
HPK20_RS02675	COG0067	glutamate synthase
HPK20_RS02675	COG0070	glutamate synthase
HPK20_RS02675	COG0069	glutamate synthase activity
HPK20_RS02685	COG0067	glutamate synthase
HPK20_RS02685	COG0070	glutamate synthase
HPK20_RS02685	COG0069	glutamate synthase activity
HPK20_RS02690	COG1242	4 iron, 4 sulfur cluster binding
HPK20_RS02695	COG5001	Diguanylate cyclase
HPK20_RS02695	COG2203	Gaf domain
HPK20_RS02695	COG3706	GGDEF domain
HPK20_RS02695	COG4251	negative regulation of phosphorylation
HPK20_RS02700	COG5002	protein histidine kinase activity
HPK20_RS02700	COG0784	Response regulator, receiver
HPK20_RS02700	COG2198	Histidine kinase
HPK20_RS02710	COG0745	RESPONSE REGULATOR receiver
HPK20_RS02720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPK20_RS02735	COG0083	homoserine kinase activity
HPK20_RS02740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPK20_RS02745	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPK20_RS02760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPK20_RS02775	COG1115	amino acid carrier protein
HPK20_RS02780	COG3022	response to hydroperoxide
HPK20_RS02790	COG0084	hydrolase, TatD family'
HPK20_RS02815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK20_RS02820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPK20_RS02825	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPK20_RS02830	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPK20_RS02835	COG0813	purine-nucleoside phosphorylase activity
HPK20_RS02845	COG0560	Phosphoserine phosphatase
HPK20_RS02855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPK20_RS02860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPK20_RS02865	COG0583	DNA-binding transcription factor activity
HPK20_RS02875	COG0583	DNA-binding transcription factor activity
HPK20_RS02915	COG4964	Belongs to the GSP D family
HPK20_RS02965	COG3437	response regulator, receiver
HPK20_RS02965	COG0784	Response regulator, receiver
HPK20_RS02970	COG2059	Chromate
HPK20_RS02985	COG2017	converts alpha-aldose to the beta-anomer
HPK20_RS02990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK20_RS03005	COG0189	ligase activity
HPK20_RS03005	COG0569	domain protein
HPK20_RS03020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPK20_RS03025	COG2171	N-acyltransferase activity
HPK20_RS03030	COG3141	response to X-ray
HPK20_RS03035	COG0583	DNA-binding transcription factor activity
HPK20_RS03045	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPK20_RS03050	COG1074	ATP-dependent DNA helicase activity
HPK20_RS03055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPK20_RS03065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPK20_RS03065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPK20_RS03075	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPK20_RS03080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPK20_RS03085	COG2166	iron-sulfur cluster assembly
HPK20_RS03095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK20_RS03100	COG0693	protein deglycase activity
HPK20_RS03105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPK20_RS03110	COG3248	Nucleoside-binding outer membrane protein
HPK20_RS03120	COG1595	DNA-templated transcription, initiation
HPK20_RS03130	COG0477	Major facilitator Superfamily
HPK20_RS03135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPK20_RS03150	COG0745	RESPONSE REGULATOR receiver
HPK20_RS03155	COG5002	protein histidine kinase activity
HPK20_RS03170	COG0248	Ppx GppA phosphatase
HPK20_RS03175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPK20_RS03180	COG0573	inorganic phosphate transmembrane transporter activity
HPK20_RS03185	COG0581	inorganic phosphate transmembrane transporter activity
HPK20_RS03190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPK20_RS03195	COG0704	Plays a role in the regulation of phosphate uptake
HPK20_RS03210	COG0450	alkyl hydroperoxide reductase
HPK20_RS03215	COG0583	DNA-binding transcription factor activity
HPK20_RS03220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPK20_RS03230	COG0517	IMP dehydrogenase activity
HPK20_RS03235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPK20_RS03245	COG1862	Preprotein translocase
HPK20_RS03250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK20_RS03255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK20_RS03260	COG1335	isochorismatase
HPK20_RS03265	COG0483	inositol monophosphate 1-phosphatase activity
HPK20_RS03270	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HPK20_RS03275	COG1959	2 iron, 2 sulfur cluster binding
HPK20_RS03280	COG1104	cysteine desulfurase activity
HPK20_RS03285	COG0822	iron-sulfur transferase activity
HPK20_RS03300	COG0443	Heat shock 70 kDa protein
HPK20_RS03305	COG0633	Ferredoxin
HPK20_RS03310	COG2975	iron-sulfur cluster assembly
HPK20_RS03315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPK20_RS03320	COG0105	UTP biosynthetic process
HPK20_RS03330	COG1426	Protein conserved in bacteria
HPK20_RS03335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPK20_RS03340	COG0124	histidyl-tRNA synthetase
HPK20_RS03345	COG2976	Protein conserved in bacteria
HPK20_RS03350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_RS03355	COG1160	GTP binding
HPK20_RS03370	COG1570	exodeoxyribonuclease VII activity
HPK20_RS03375	COG0516	GMP reductase activity
HPK20_RS03375	COG0517	IMP dehydrogenase activity
HPK20_RS03380	COG0519	Catalyzes the synthesis of GMP from XMP
HPK20_RS03380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPK20_RS03385	COG0582	viral genome integration into host DNA
HPK20_RS03470	COG1584	GPR1 FUN34 yaaH family protein
HPK20_RS03485	COG1473	amidohydrolase
HPK20_RS03495	COG1115	amino acid carrier protein
HPK20_RS03505	COG0583	DNA-binding transcription factor activity
HPK20_RS03605	COG0210	DNA helicase
HPK20_RS03630	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPK20_RS03645	COG0582	viral genome integration into host DNA
HPK20_RS03655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPK20_RS03660	COG2867	negative regulation of translational initiation
HPK20_RS03665	COG2914	Belongs to the UPF0125 (RnfH) family
HPK20_RS03670	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_RS03675	COG0497	DNA recombination
HPK20_RS03680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPK20_RS03685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPK20_RS03695	COG0443	Heat shock 70 kDa protein
HPK20_RS03700	COG0484	heat shock protein binding
HPK20_RS03705	COG4969	Belongs to the N-Me-Phe pilin family
HPK20_RS03730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPK20_RS03740	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HPK20_RS03745	COG0583	DNA-binding transcription factor activity
HPK20_RS03750	COG0590	tRNA wobble adenosine to inosine editing
HPK20_RS03755	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPK20_RS03780	COG0442	prolyl-tRNA aminoacylation
HPK20_RS03785	COG1720	tRNA m6t6A37 methyltransferase activity
HPK20_RS03790	COG0254	rRNA binding
HPK20_RS03795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPK20_RS03800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPK20_RS03805	COG1671	Belongs to the UPF0178 family
HPK20_RS03830	COG3098	single-species biofilm formation
HPK20_RS03835	COG0564	pseudouridine synthase activity
HPK20_RS03840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPK20_RS03845	COG0142	geranyltranstransferase activity
HPK20_RS03850	COG1722	exodeoxyribonuclease VII activity
HPK20_RS03855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPK20_RS03865	COG0301	tRNA thio-modification
HPK20_RS03865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK20_RS03870	COG0583	DNA-binding transcription factor activity
HPK20_RS03880	COG2363	Small membrane protein
HPK20_RS03890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK20_RS03895	COG1611	Belongs to the LOG family
HPK20_RS03910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPK20_RS03910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPK20_RS03920	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPK20_RS03925	COG1464	Belongs to the NlpA lipoprotein family
HPK20_RS03930	COG2011	ABC-type metal ion transport system permease component
HPK20_RS03935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPK20_RS03940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPK20_RS03955	COG1263	PTS System
HPK20_RS03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_RS03960	COG0366	Alpha amylase catalytic
HPK20_RS03985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_RS03990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK20_RS04000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPK20_RS04010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPK20_RS04015	COG0321	lipoyl(octanoyl) transferase activity
HPK20_RS04020	COG2921	Belongs to the UPF0250 family
HPK20_RS04025	COG1686	Belongs to the peptidase S11 family
HPK20_RS04030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPK20_RS04035	COG0772	Belongs to the SEDS family
HPK20_RS04040	COG0768	penicillin binding
HPK20_RS04045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPK20_RS04050	COG0799	negative regulation of ribosome biogenesis
HPK20_RS04055	COG1466	dna polymerase III delta subunit
HPK20_RS04060	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPK20_RS04070	COG2888	peptidyl-tyrosine sulfation
HPK20_RS04075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPK20_RS04080	COG4535	Mg2 and Co2 transporter CorC
HPK20_RS04085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPK20_RS04090	COG1702	phosphate starvation-inducible protein PhoH
HPK20_RS04095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPK20_RS04100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPK20_RS04105	COG2190	(PTS) system
HPK20_RS04115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS04120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPK20_RS04125	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPK20_RS04130	COG3115	cell septum assembly
HPK20_RS04135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPK20_RS04150	COG0789	Transcriptional regulator
HPK20_RS04160	COG0330	HflC and HflK could
HPK20_RS04165	COG3118	belongs to the thioredoxin family
HPK20_RS04170	COG0300	oxidoreductase activity
HPK20_RS04175	COG1090	epimerase
HPK20_RS04200	COG0622	Phosphoesterase
HPK20_RS04215	COG3710	Transcriptional regulator
HPK20_RS04220	COG0326	Molecular chaperone. Has ATPase activity
HPK20_RS04230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPK20_RS04235	COG3104	oligopeptide transport
HPK20_RS04245	COG0367	asparagine synthase
HPK20_RS04250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPK20_RS04250	COG4651	solute:proton antiporter activity
HPK20_RS04255	COG1940	carbohydrate kinase activity
HPK20_RS04255	COG1846	Transcriptional regulator
HPK20_RS04260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK20_RS04265	COG2190	(PTS) system
HPK20_RS04265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_RS04265	COG1263	PTS System
HPK20_RS04280	COG0101	tRNA pseudouridine synthase activity
HPK20_RS04285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPK20_RS04290	COG0285	dihydrofolate synthase activity
HPK20_RS04295	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPK20_RS04300	COG1286	toxin biosynthetic process
HPK20_RS04305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPK20_RS04310	COG2056	Na+-H+ antiporter family
HPK20_RS04315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPK20_RS04330	COG0346	lactoylglutathione lyase activity
HPK20_RS04335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPK20_RS04340	COG4660	Part of a membrane complex involved in electron transport
HPK20_RS04345	COG4659	FMN binding
HPK20_RS04350	COG4658	electron transport chain
HPK20_RS04355	COG4656	Part of a membrane complex involved in electron transport
HPK20_RS04365	COG4657	Part of a membrane complex involved in electron transport
HPK20_RS04370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK20_RS04385	COG0556	nucleotide-excision repair
HPK20_RS04390	COG2204	response regulator
HPK20_RS04395	COG2198	Histidine kinase
HPK20_RS04400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPK20_RS04405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPK20_RS04410	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPK20_RS04415	COG0315	cyclic pyranopterin monophosphate synthase activity
HPK20_RS04420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPK20_RS04425	COG0314	molybdopterin synthase activity
HPK20_RS04430	COG3706	GGDEF domain
HPK20_RS04435	COG0617	tRNA 3'-terminal CCA addition
HPK20_RS04435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPK20_RS04435	COG0517	IMP dehydrogenase activity
HPK20_RS04445	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPK20_RS04455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK20_RS04455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK20_RS04460	COG0489	protein tyrosine kinase activity
HPK20_RS04465	COG0572	uridine kinase
HPK20_RS04470	COG2982	Protein involved in outer membrane biogenesis
HPK20_RS04475	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPK20_RS04490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPK20_RS04515	COG0183	Belongs to the thiolase family
HPK20_RS04520	COG1024	Enoyl-CoA hydratase
HPK20_RS04520	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPK20_RS04525	COG0778	Nitroreductase
HPK20_RS04530	COG0583	DNA-binding transcription factor activity
HPK20_RS04535	COG0745	RESPONSE REGULATOR receiver
HPK20_RS04540	COG2832	Protein of unknown function (DUF454)
HPK20_RS04545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPK20_RS04555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPK20_RS04560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPK20_RS04565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPK20_RS04575	COG2983	Belongs to the UPF0260 family
HPK20_RS04595	COG2226	methyltransferase
HPK20_RS04605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK20_RS04610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_RS04620	COG3139	Protein of unknown function (DUF1315)
HPK20_RS04625	COG0252	asparaginase activity
HPK20_RS04630	COG0616	signal peptide processing
HPK20_RS04635	COG1902	pentaerythritol trinitrate reductase activity
HPK20_RS04635	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPK20_RS04640	COG0788	formyltetrahydrofolate deformylase activity
HPK20_RS04650	COG1199	ATP-dependent helicase activity
HPK20_RS04655	COG1214	PFAM Peptidase M22, glycoprotease
HPK20_RS04675	COG0318	PFAM AMP-dependent synthetase and ligase
HPK20_RS04680	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPK20_RS04690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPK20_RS04695	COG2894	cell division
HPK20_RS04705	COG3100	YcgL domain-containing protein
HPK20_RS04710	COG2951	lytic endotransglycosylase activity
HPK20_RS04720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK20_RS04725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPK20_RS04735	COG3842	ATPase activity
HPK20_RS04745	COG1840	ABC-type Fe3 transport system, periplasmic component
HPK20_RS04750	COG2271	Major facilitator Superfamily
HPK20_RS04755	COG3851	Histidine kinase
HPK20_RS04760	COG2197	response regulator
HPK20_RS04795	COG4589	Belongs to the CDS family
HPK20_RS04805	COG1716	ATPase activity
HPK20_RS04805	COG5001	Diguanylate cyclase
HPK20_RS04815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK20_RS04815	COG3153	acetyltransferase
HPK20_RS04825	COG1760	l-serine dehydratase
HPK20_RS04830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPK20_RS04835	COG0745	RESPONSE REGULATOR receiver
HPK20_RS04850	COG1404	Belongs to the peptidase S8 family
HPK20_RS04855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPK20_RS04860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPK20_RS04865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPK20_RS04870	COG2204	response regulator
HPK20_RS04875	COG4191	Histidine kinase
HPK20_RS04880	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPK20_RS04890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPK20_RS04895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPK20_RS04900	COG0776	regulation of translation
HPK20_RS04905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPK20_RS04910	COG1555	photosystem II stabilization
HPK20_RS04915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPK20_RS04920	COG0539	negative regulation of cytoplasmic translation
HPK20_RS04930	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPK20_RS04935	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPK20_RS04955	COG0583	DNA-binding transcription factor activity
HPK20_RS04965	COG0686	Belongs to the AlaDH PNT family
HPK20_RS04970	COG1522	sequence-specific DNA binding
HPK20_RS04975	COG1674	ftsk spoiiie
HPK20_RS04980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPK20_RS04985	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPK20_RS04990	COG2186	Transcriptional regulator
HPK20_RS05005	COG0537	adenosine 5'-monophosphoramidase activity
HPK20_RS05035	COG1252	NADH dehydrogenase
HPK20_RS05050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPK20_RS05060	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPK20_RS05065	COG1136	(ABC) transporter
HPK20_RS05070	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPK20_RS05080	COG2333	competence protein COMEC
HPK20_RS05080	COG0658	competence protein
HPK20_RS05085	COG1132	(ABC) transporter
HPK20_RS05100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPK20_RS05105	COG2719	SpoVR family
HPK20_RS05110	COG2718	Belongs to the UPF0229 family
HPK20_RS05115	COG2766	serine protein kinase
HPK20_RS05135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPK20_RS05150	COG1882	Formate acetyltransferase
HPK20_RS05175	COG4160	amino acid transport
HPK20_RS05180	COG0708	Exodeoxyribonuclease III
HPK20_RS05195	COG3923	Primosomal replication protein n
HPK20_RS05200	COG1199	ATP-dependent helicase activity
HPK20_RS05205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPK20_RS05215	COG3012	SEC-C Motif Domain Protein
HPK20_RS05220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPK20_RS05225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPK20_RS05230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPK20_RS05235	COG0215	cysteine-tRNA ligase activity
HPK20_RS05240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPK20_RS05245	COG0632	four-way junction helicase activity
HPK20_RS05250	COG2255	four-way junction helicase activity
HPK20_RS05255	COG1271	oxidase subunit
HPK20_RS05260	COG1294	oxidase, subunit
HPK20_RS05265	COG4890	Cyd operon protein YbgT
HPK20_RS05275	COG0824	Thioesterase
HPK20_RS05280	COG0811	peptide transport
HPK20_RS05300	COG2885	chlorophyll binding
HPK20_RS05305	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HPK20_RS05310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPK20_RS05320	COG5002	protein histidine kinase activity
HPK20_RS05320	COG0784	Response regulator, receiver
HPK20_RS05335	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_RS05355	COG1960	acyl-CoA dehydrogenase activity
HPK20_RS05360	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPK20_RS05375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPK20_RS05380	COG1979	alcohol dehydrogenase
HPK20_RS05385	COG1737	Transcriptional regulator
HPK20_RS05390	COG0076	glutamate decarboxylase activity
HPK20_RS05400	COG2431	L-lysine efflux transmembrane transporter activity
HPK20_RS05410	COG3070	regulator of competence-specific genes
HPK20_RS05425	COG3852	Histidine kinase
HPK20_RS05435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPK20_RS05440	COG1032	radical SAM domain protein
HPK20_RS05445	COG0488	(ABC) transporter
HPK20_RS05465	COG0745	RESPONSE REGULATOR receiver
HPK20_RS05470	COG5002	protein histidine kinase activity
HPK20_RS05475	COG0346	lactoylglutathione lyase activity
HPK20_RS05480	COG1794	racemase activity, acting on amino acids and derivatives
HPK20_RS05495	COG0840	transmembrane signaling receptor activity
HPK20_RS05500	COG2771	luxR family
HPK20_RS05500	COG2200	EAL domain
HPK20_RS05510	COG0625	glutathione transferase activity
HPK20_RS05530	COG0612	Peptidase, M16
HPK20_RS05545	COG0583	DNA-binding transcription factor activity
HPK20_RS05550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPK20_RS05560	COG2350	Protein conserved in bacteria
HPK20_RS05580	COG1301	dicarboxylic acid transport
HPK20_RS05590	COG0133	tryptophan synthase activity
HPK20_RS05595	COG0135	phosphoribosylanthranilate isomerase activity
HPK20_RS05595	COG0134	indole-3-glycerol-phosphate synthase activity
HPK20_RS05600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPK20_RS05605	COG0512	Glutamine amidotransferase of anthranilate synthase
HPK20_RS05610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK20_RS05620	COG0613	PHP domain protein
HPK20_RS05625	COG0009	L-threonylcarbamoyladenylate synthase
HPK20_RS05630	COG1187	pseudouridine synthase activity
HPK20_RS05650	COG0739	heme binding
HPK20_RS05655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPK20_RS05660	COG4988	ABC transporter
HPK20_RS05665	COG0492	ferredoxin-NADP+ reductase activity
HPK20_RS05685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK20_RS05690	COG1454	alcohol dehydrogenase
HPK20_RS05700	COG1414	Transcriptional regulator
HPK20_RS05705	COG1414	Transcriptional regulator
HPK20_RS05715	COG2949	membrane
HPK20_RS05740	COG0640	Transcriptional regulator
HPK20_RS05755	COG0583	DNA-binding transcription factor activity
HPK20_RS05780	COG0281	malic enzyme
HPK20_RS05785	COG1643	Atp-dependent helicase
HPK20_RS05795	COG1757	Na H antiporter
HPK20_RS05800	COG0174	glutamine synthetase
HPK20_RS05805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HPK20_RS05810	COG1396	sequence-specific DNA binding
HPK20_RS05810	COG1917	Cupin 2, conserved barrel domain protein
HPK20_RS05815	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_RS05820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPK20_RS05830	COG2957	Belongs to the agmatine deiminase family
HPK20_RS05840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK20_RS05845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPK20_RS05865	COG2885	chlorophyll binding
HPK20_RS05880	COG0277	FAD linked oxidase domain protein
HPK20_RS05880	COG0247	lactate metabolic process
HPK20_RS05900	COG2986	histidine ammonia-lyase
HPK20_RS05910	COG0010	Belongs to the arginase family
HPK20_RS05915	COG1228	amidohydrolase
HPK20_RS05930	COG3099	Belongs to the UPF0263 family
HPK20_RS05935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPK20_RS05945	COG5001	Diguanylate cyclase
HPK20_RS05950	COG0417	DNA replication proofreading
HPK20_RS05955	COG2197	response regulator
HPK20_RS05960	COG0322	excinuclease ABC activity
HPK20_RS05990	COG2133	pyrroloquinoline quinone binding
HPK20_RS06010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPK20_RS06015	COG0072	phenylalanine-tRNA ligase activity
HPK20_RS06015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK20_RS06020	COG0776	regulation of translation
HPK20_RS06030	COG0500	methyltransferase
HPK20_RS06060	COG3300	MHYT domain
HPK20_RS06060	COG5001	Diguanylate cyclase
HPK20_RS06065	COG0295	cytidine deaminase activity
HPK20_RS06070	COG1346	cytolysis
HPK20_RS06075	COG1380	Effector of murein hydrolase LrgA
HPK20_RS06080	COG2925	Exonuclease
HPK20_RS06095	COG0702	epimerase
HPK20_RS06100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPK20_RS06105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPK20_RS06110	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPK20_RS06125	COG2988	succinylglutamate desuccinylase activity
HPK20_RS06130	COG4139	cobalamin transport
HPK20_RS06135	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPK20_RS06180	COG0583	DNA-binding transcription factor activity
HPK20_RS06190	COG1451	nucleotide metabolic process
HPK20_RS06205	COG3063	Type IV pilus biogenesis stability protein PilW
HPK20_RS06210	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPK20_RS06230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_RS06245	COG3290	protein histidine kinase activity
HPK20_RS06250	COG4565	transcriptional regulatory protein
HPK20_RS06260	COG0784	Response regulator, receiver
HPK20_RS06260	COG0835	chemotaxis
HPK20_RS06315	COG1278	Cold shock
HPK20_RS06350	COG0668	transmembrane transport
HPK20_RS06365	COG0745	RESPONSE REGULATOR receiver
HPK20_RS06370	COG5002	protein histidine kinase activity
HPK20_RS06415	COG3391	amine dehydrogenase activity
HPK20_RS06420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPK20_RS06425	COG1254	Belongs to the acylphosphatase family
HPK20_RS06430	COG2920	part of a sulfur-relay system
HPK20_RS06435	COG0670	Belongs to the BI1 family
HPK20_RS06440	COG1126	abc transporter atp-binding protein
HPK20_RS06445	COG0765	amino acid transport
HPK20_RS06450	COG4597	amino acid ABC transporter
HPK20_RS06455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_RS06465	COG0561	phosphatase activity
HPK20_RS06470	COG0602	queuosine metabolic process
HPK20_RS06480	COG3005	denitrification pathway
HPK20_RS06485	COG0243	molybdopterin cofactor binding
HPK20_RS06515	COG2999	glutathione oxidoreductase activity
HPK20_RS06530	COG3706	GGDEF domain
HPK20_RS06540	COG3706	GGDEF domain
HPK20_RS06545	COG0443	Heat shock 70 kDa protein
HPK20_RS06560	COG3706	GGDEF domain
HPK20_RS06585	COG3005	denitrification pathway
HPK20_RS06595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPK20_RS06600	COG1643	Atp-dependent helicase
HPK20_RS06610	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPK20_RS06620	COG3501	Rhs element vgr protein
HPK20_RS06645	COG1115	amino acid carrier protein
HPK20_RS06660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_RS06665	COG1666	GTP binding
HPK20_RS06670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPK20_RS06675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPK20_RS06675	COG0574	Belongs to the PEP-utilizing enzyme family
HPK20_RS06690	COG2996	Protein conserved in bacteria
HPK20_RS06700	COG3008	intermembrane lipid transfer
HPK20_RS06705	COG2995	paraquat-inducible protein a
HPK20_RS06710	COG1132	(ABC) transporter
HPK20_RS06715	COG1956	GAF domain-containing protein
HPK20_RS06740	COG0308	aminopeptidase N
HPK20_RS06755	COG0167	dihydroorotate dehydrogenase activity
HPK20_RS06765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPK20_RS06765	COG0116	Belongs to the methyltransferase superfamily
HPK20_RS06790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPK20_RS06795	COG1067	ATP-dependent peptidase activity
HPK20_RS06800	COG3120	sequence-specific DNA binding
HPK20_RS06820	COG0784	Response regulator, receiver
HPK20_RS06820	COG2205	protein histidine kinase activity
HPK20_RS06835	COG3278	Belongs to the heme-copper respiratory oxidase family
HPK20_RS06850	COG2010	Cytochrome c
HPK20_RS06860	COG2217	Heavy metal translocating P-type atpase
HPK20_RS06875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPK20_RS06880	COG0589	response to stress
HPK20_RS06905	COG3842	ATPase activity
HPK20_RS06915	COG1177	transmembrane transport
HPK20_RS06925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPK20_RS06930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPK20_RS06935	COG0004	ammonium transporteR
HPK20_RS06950	COG0437	4 iron, 4 sulfur cluster binding
HPK20_RS06955	COG0243	molybdopterin cofactor binding
HPK20_RS06955	COG3383	formate dehydrogenase (NAD+) activity
HPK20_RS06965	COG3381	protein complex oligomerization
HPK20_RS06985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPK20_RS07000	COG3852	Histidine kinase
HPK20_RS07005	COG2204	response regulator
HPK20_RS07015	COG4662	Binding-protein-dependent transport system inner membrane component
HPK20_RS07020	COG3842	ATPase activity
HPK20_RS07025	COG0746	molybdenum cofactor guanylyltransferase activity
HPK20_RS07030	COG0303	'Molybdopterin
HPK20_RS07040	COG1940	carbohydrate kinase activity
HPK20_RS07055	COG0840	transmembrane signaling receptor activity
HPK20_RS07060	COG0791	NLP P60 protein
HPK20_RS07070	COG3001	Fructosamine kinase
HPK20_RS07080	COG0307	riboflavin synthase, alpha
HPK20_RS07095	COG1793	dna ligase
HPK20_RS07100	COG4667	esterase of the alpha-beta hydrolase superfamily
HPK20_RS07120	COG0848	biopolymer transport protein
HPK20_RS07125	COG0811	peptide transport
HPK20_RS07130	COG0811	peptide transport
HPK20_RS07140	COG3040	lipid binding
HPK20_RS07145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK20_RS07150	COG0039	L-malate dehydrogenase activity
HPK20_RS07155	COG1653	transport
HPK20_RS07165	COG0395	ABC-type sugar transport system, permease component
HPK20_RS07170	COG3842	ATPase activity
HPK20_RS07175	COG1349	DNA-binding transcription factor activity
HPK20_RS07180	COG0584	glycerophosphoryl diester phosphodiesterase
HPK20_RS07185	COG2731	YhcH YjgK YiaL family protein
HPK20_RS07205	COG0625	glutathione transferase activity
HPK20_RS07215	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPK20_RS07225	COG2200	EAL domain
HPK20_RS07230	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK20_RS07245	COG2814	Major facilitator Superfamily
HPK20_RS07250	COG1566	PFAM secretion protein HlyD family protein
HPK20_RS07265	COG2828	Protein conserved in bacteria
HPK20_RS07270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPK20_RS07275	COG0372	Belongs to the citrate synthase family
HPK20_RS07280	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPK20_RS07290	COG2169	Transcriptional regulator
HPK20_RS07290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPK20_RS07325	COG1129	ABC transporter
HPK20_RS07335	COG3250	beta-galactosidase activity
HPK20_RS07345	COG2991	Protein conserved in bacteria
HPK20_RS07350	COG0778	Nitroreductase
HPK20_RS07355	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPK20_RS07360	COG0583	DNA-binding transcription factor activity
HPK20_RS07370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_RS07370	COG4191	Histidine kinase
HPK20_RS07375	COG0471	metal ion transport
HPK20_RS07395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK20_RS07405	COG3768	UPF0283 membrane protein
HPK20_RS07410	COG3106	COG3106 Predicted ATPase
HPK20_RS07425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK20_RS07440	COG0494	nUDIX hydrolase
HPK20_RS07445	COG0814	amino acid
HPK20_RS07450	COG1760	l-serine dehydratase
HPK20_RS07455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_RS07460	COG1136	(ABC) transporter
HPK20_RS07460	COG0577	efflux transmembrane transporter activity
HPK20_RS07470	COG0720	synthase
HPK20_RS07475	COG0840	transmembrane signaling receptor activity
HPK20_RS07480	COG0017	Asparaginyl-tRNA synthetase
HPK20_RS07500	COG1448	Aminotransferase
HPK20_RS07510	COG0517	IMP dehydrogenase activity
HPK20_RS07515	COG2176	DNA-directed DNA polymerase activity
HPK20_RS07520	COG0840	transmembrane signaling receptor activity
HPK20_RS07525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPK20_RS07530	COG1846	Transcriptional regulator
HPK20_RS07535	COG2197	response regulator
HPK20_RS07550	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_RS07565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK20_RS07570	COG3108	Peptidase M15
HPK20_RS07575	COG2989	Protein conserved in bacteria
HPK20_RS07600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPK20_RS07615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPK20_RS07620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPK20_RS07650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPK20_RS07655	COG3265	gluconokinase activity
HPK20_RS07670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_RS07715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPK20_RS07730	COG4181	ATPase activity
HPK20_RS07735	COG0534	Mate efflux family protein
HPK20_RS07740	COG0702	epimerase
HPK20_RS07750	COG2814	Major facilitator Superfamily
HPK20_RS07760	COG1061	Type III restriction enzyme res subunit
HPK20_RS07770	COG0745	RESPONSE REGULATOR receiver
HPK20_RS07775	COG2205	protein histidine kinase activity
HPK20_RS07780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPK20_RS07815	COG0714	Associated with various cellular activities
HPK20_RS07820	COG0641	radical SAM
HPK20_RS07825	COG3119	arylsulfatase activity
HPK20_RS07835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPK20_RS07845	COG1278	Cold shock
HPK20_RS07855	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPK20_RS07860	COG3706	GGDEF domain
HPK20_RS07875	COG0814	amino acid
HPK20_RS07885	COG1131	(ABC) transporter
HPK20_RS07890	COG0842	Transport permease protein
HPK20_RS07900	COG3313	Fe-S protein
HPK20_RS07910	COG4134	Bacterial extracellular solute-binding protein
HPK20_RS07915	COG4135	transport system, permease component
HPK20_RS07920	COG4136	ATPase activity
HPK20_RS07925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPK20_RS07930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPK20_RS07940	COG0564	pseudouridine synthase activity
HPK20_RS07960	COG0733	neurotransmitter:sodium symporter activity
HPK20_RS07970	COG0626	cystathionine gamma-synthase activity
HPK20_RS08000	COG0519	Catalyzes the synthesis of GMP from XMP
HPK20_RS08015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_RS08030	COG1842	Phage shock protein A
HPK20_RS08035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPK20_RS08045	COG4168	peptide transport system, permease
HPK20_RS08050	COG4171	peptide transport system, permease
HPK20_RS08060	COG4172	Belongs to the ABC transporter superfamily
HPK20_RS08075	COG1227	inorganic diphosphatase activity
HPK20_RS08095	COG0243	molybdopterin cofactor binding
HPK20_RS08100	COG3005	denitrification pathway
HPK20_RS08105	COG4459	periplasmic nitrate reductase
HPK20_RS08110	COG0390	transport system, permease component
HPK20_RS08115	COG2116	formate transmembrane transporter activity
HPK20_RS08135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPK20_RS08140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPK20_RS08145	COG1435	thymidine kinase activity
HPK20_RS08160	COG4106	trans-aconitate 2-methyltransferase activity
HPK20_RS08165	COG0500	methyltransferase
HPK20_RS08170	COG0189	ligase activity
HPK20_RS08170	COG4067	protein conserved in archaea
HPK20_RS08180	COG0189	ligase activity
HPK20_RS08185	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HPK20_RS08190	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPK20_RS08195	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPK20_RS08200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPK20_RS08205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPK20_RS08210	COG0745	RESPONSE REGULATOR receiver
HPK20_RS08215	COG3381	protein complex oligomerization
HPK20_RS08220	COG1609	Transcriptional regulator
HPK20_RS08225	COG3070	regulator of competence-specific genes
HPK20_RS08245	COG0297	glycogen (starch) synthase activity
HPK20_RS08250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPK20_RS08260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPK20_RS08280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPK20_RS08285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPK20_RS08290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPK20_RS08295	COG0542	response to heat
HPK20_RS08300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPK20_RS08305	COG1278	Cold shock
HPK20_RS08315	COG1187	pseudouridine synthase activity
HPK20_RS08320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPK20_RS08320	COG0140	phosphoribosyl-ATP diphosphatase activity
HPK20_RS08330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPK20_RS08335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPK20_RS08340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPK20_RS08340	COG0131	Imidazoleglycerol-phosphate dehydratase
HPK20_RS08345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPK20_RS08350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPK20_RS08355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPK20_RS08365	COG1757	Na H antiporter
HPK20_RS08370	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPK20_RS08375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_RS08380	COG0482	sulfurtransferase activity
HPK20_RS08385	COG2915	High frequency lysogenization protein hflD homolog
HPK20_RS08390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPK20_RS08410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPK20_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS08435	COG0501	Belongs to the peptidase M48B family
HPK20_RS08445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPK20_RS08450	COG2226	methyltransferase
HPK20_RS08460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPK20_RS08465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPK20_RS08475	COG2146	nitrite reductase [NAD(P)H] activity
HPK20_RS08475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPK20_RS08480	COG1116	anion transmembrane transporter activity
HPK20_RS08485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPK20_RS08490	COG1116	anion transmembrane transporter activity
HPK20_RS08490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPK20_RS08505	COG1648	precorrin-2 dehydrogenase activity
HPK20_RS08505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPK20_RS08510	COG0243	molybdopterin cofactor binding
HPK20_RS08520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPK20_RS08525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPK20_RS08530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPK20_RS08535	COG0653	protein targeting
HPK20_RS08550	COG3706	GGDEF domain
HPK20_RS08560	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPK20_RS08570	COG3092	negative regulation of chromosome organization
HPK20_RS08575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPK20_RS08580	COG0857	belongs to the CobB CobQ family
HPK20_RS08580	COG0280	phosphate acetyltransferase
HPK20_RS08585	COG3174	membrane
HPK20_RS08590	COG0435	Glutathione S-transferase
HPK20_RS08605	COG0444	Belongs to the ABC transporter superfamily
HPK20_RS08610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK20_RS08615	COG0601	transmembrane transport
HPK20_RS08645	COG0204	Acyl-transferase
HPK20_RS08645	COG0318	PFAM AMP-dependent synthetase and ligase
HPK20_RS08650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPK20_RS08655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPK20_RS08665	COG0318	PFAM AMP-dependent synthetase and ligase
HPK20_RS08675	COG1216	Glycosyl transferase, family 2
HPK20_RS08680	COG2986	histidine ammonia-lyase
HPK20_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS08730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_RS08740	COG2202	Pas domain
HPK20_RS08740	COG2200	EAL domain
HPK20_RS08740	COG2199	diguanylate cyclase activity
HPK20_RS08745	COG1621	beta-fructofuranosidase activity
HPK20_RS08755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_RS08755	COG1263	PTS System
HPK20_RS08765	COG0745	RESPONSE REGULATOR receiver
HPK20_RS08775	COG2207	Transcriptional regulator
HPK20_RS08775	COG3708	Transcriptional regulator
HPK20_RS08780	COG2814	Major facilitator Superfamily
HPK20_RS08785	COG1566	PFAM secretion protein HlyD family protein
HPK20_RS08790	COG1538	Outer membrane efflux protein
HPK20_RS08800	COG0747	negative chemotaxis
HPK20_RS08805	COG0601	transmembrane transport
HPK20_RS08810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK20_RS08815	COG4172	Belongs to the ABC transporter superfamily
HPK20_RS08820	COG0351	phosphomethylpyrimidine kinase
HPK20_RS08830	COG0352	thiamine-phosphate diphosphorylase activity
HPK20_RS08835	COG1741	Belongs to the pirin family
HPK20_RS08840	COG2723	6-phospho-beta-galactosidase activity
HPK20_RS08845	COG1609	Transcriptional regulator
HPK20_RS08855	COG1120	ATPase activity
HPK20_RS08860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPK20_RS08870	COG1629	transport
HPK20_RS08870	COG4774	siderophore transport
HPK20_RS08875	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_RS08880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_RS08885	COG4592	Periplasmic binding protein
HPK20_RS08900	COG3433	isochorismatase activity
HPK20_RS08900	COG2226	methyltransferase
HPK20_RS08900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPK20_RS08905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPK20_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS08915	COG1169	isochorismate synthase
HPK20_RS08920	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPK20_RS08930	COG2814	Major facilitator Superfamily
HPK20_RS08935	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPK20_RS08975	COG1294	oxidase, subunit
HPK20_RS08980	COG1271	oxidase subunit
HPK20_RS08985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_RS09000	COG3258	Cytochrome c
HPK20_RS09005	COG2863	cytochrome
HPK20_RS09050	COG2194	sulfuric ester hydrolase activity
HPK20_RS09055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPK20_RS09060	COG1368	sulfuric ester hydrolase activity
HPK20_RS09065	COG0513	Belongs to the DEAD box helicase family
HPK20_RS09075	COG0671	phosphoesterase, PA-phosphatase related
HPK20_RS09085	COG0642	Histidine kinase
HPK20_RS09100	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_RS09105	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK20_RS09135	COG2207	Transcriptional regulator
HPK20_RS09140	COG1881	PFAM PEBP family protein
HPK20_RS09145	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPK20_RS09150	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPK20_RS09150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPK20_RS09155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_RS09160	COG2207	Transcriptional regulator
HPK20_RS09185	COG1278	Cold shock
HPK20_RS09195	COG0697	spore germination
HPK20_RS09200	COG0431	NADPH-dependent FMN reductase
HPK20_RS09215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPK20_RS09240	COG1073	alpha beta
HPK20_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS09255	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS09270	COG4221	oxidoreductase activity
HPK20_RS09290	COG1309	transcriptional regulator
HPK20_RS09310	COG2203	Gaf domain
HPK20_RS09310	COG2199	diguanylate cyclase activity
HPK20_RS09325	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HPK20_RS09330	COG1946	Acyl-CoA thioesterase
HPK20_RS09335	COG1522	sequence-specific DNA binding
HPK20_RS09380	COG2885	chlorophyll binding
HPK20_RS09410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPK20_RS09425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPK20_RS09430	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPK20_RS09450	COG1580	Controls the rotational direction of flagella during chemotaxis
HPK20_RS09455	COG1191	sigma factor activity
HPK20_RS09460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPK20_RS09465	COG1360	Flagellar Motor Protein
HPK20_RS09475	COG3015	lipoprotein NlpE involved in copper resistance
HPK20_RS09480	COG0702	epimerase
HPK20_RS09510	COG1256	bacterial-type flagellum assembly
HPK20_RS09510	COG4786	Flagellar basal body rod
HPK20_RS09520	COG1706	bacterial-type flagellum-dependent cell motility
HPK20_RS09525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPK20_RS09530	COG4786	Flagellar basal body rod
HPK20_RS09540	COG1749	Flagellar hook protein flgE
HPK20_RS09545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPK20_RS09550	COG1558	bacterial-type flagellum-dependent cell motility
HPK20_RS09555	COG1815	bacterial-type flagellum-dependent cell motility
HPK20_RS09575	COG0741	lytic transglycosylase activity
HPK20_RS09575	COG1388	LysM domain
HPK20_RS09580	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPK20_RS09600	COG0477	Major facilitator Superfamily
HPK20_RS09605	COG2855	membrane
HPK20_RS09625	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPK20_RS09630	COG0596	Alpha beta hydrolase
HPK20_RS09635	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPK20_RS09640	COG1169	isochorismate synthase
HPK20_RS09645	COG0436	Aminotransferase
HPK20_RS09650	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPK20_RS09655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPK20_RS09700	COG0616	signal peptide processing
HPK20_RS09705	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS09720	COG0587	DNA-directed DNA polymerase activity
HPK20_RS09725	COG0784	Response regulator, receiver
HPK20_RS09725	COG0835	chemotaxis
HPK20_RS09730	COG1940	carbohydrate kinase activity
HPK20_RS09735	COG0469	pyruvate kinase activity
HPK20_RS09740	COG4667	esterase of the alpha-beta hydrolase superfamily
HPK20_RS09755	COG0733	neurotransmitter:sodium symporter activity
HPK20_RS09770	COG1263	PTS System
HPK20_RS09770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_RS09780	COG2190	(PTS) system
HPK20_RS09780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_RS09780	COG1263	PTS System
HPK20_RS09785	COG0084	hydrolase, TatD family'
HPK20_RS09790	COG0470	DNA polymerase III
HPK20_RS09795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPK20_RS09800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPK20_RS09805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPK20_RS09810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPK20_RS09830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK20_RS09835	COG0416	fatty acid biosynthetic process
HPK20_RS09840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPK20_RS09845	COG1399	metal-binding, possibly nucleic acid-binding protein
HPK20_RS09850	COG0424	maF-like protein
HPK20_RS09855	COG0564	pseudouridine synthase activity
HPK20_RS09860	COG1530	ribonuclease E activity
HPK20_RS09870	COG0659	secondary active sulfate transmembrane transporter activity
HPK20_RS09880	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_RS09880	COG1454	alcohol dehydrogenase
HPK20_RS09885	COG2095	MarC family integral membrane protein
HPK20_RS09890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPK20_RS09895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPK20_RS09900	COG1757	Na H antiporter
HPK20_RS09915	COG3081	Nucleoid-associated protein
HPK20_RS09920	COG3082	Protein of unknown function (DUF1414)
HPK20_RS09925	COG3083	sulfuric ester hydrolase activity
HPK20_RS09950	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPK20_RS09965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPK20_RS10005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPK20_RS10010	COG2159	amidohydrolase
HPK20_RS10015	COG0583	DNA-binding transcription factor activity
HPK20_RS10030	COG0667	Aldo Keto reductase
HPK20_RS10055	COG3384	dioxygenase
HPK20_RS10060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPK20_RS10065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPK20_RS10085	COG2853	Lipoprotein
HPK20_RS10100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK20_RS10105	COG1138	Cytochrome C-type biogenesis protein
HPK20_RS10110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPK20_RS10115	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK20_RS10120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK20_RS10125	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK20_RS10130	COG4133	protoheme IX ABC transporter activity
HPK20_RS10140	COG0835	chemotaxis
HPK20_RS10150	COG1192	Involved in chromosome partitioning
HPK20_RS10155	COG2201	protein-glutamate methylesterase activity
HPK20_RS10160	COG0643	Histidine kinase
HPK20_RS10160	COG2198	Histidine kinase
HPK20_RS10160	COG0784	Response regulator, receiver
HPK20_RS10165	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPK20_RS10195	COG2062	phosphohistidine phosphatase, SixA
HPK20_RS10205	COG3102	Protein conserved in bacteria
HPK20_RS10210	COG0018	arginyl-trna synthetase
HPK20_RS10230	COG1918	ferrous iron import across plasma membrane
HPK20_RS10240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPK20_RS10245	COG1121	(ABC) transporter
HPK20_RS10250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPK20_RS10265	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPK20_RS10270	COG0567	Dehydrogenase, E1 component
HPK20_RS10285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPK20_RS10300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPK20_RS10310	COG0033	Phosphoglucomutase
HPK20_RS10315	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPK20_RS10320	COG0596	Alpha beta hydrolase
HPK20_RS10335	COG1346	cytolysis
HPK20_RS10340	COG1380	Effector of murein hydrolase LrgA
HPK20_RS10345	COG0583	DNA-binding transcription factor activity
HPK20_RS10355	COG0735	belongs to the Fur family
HPK20_RS10360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPK20_RS10365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_RS10370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPK20_RS10375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPK20_RS10375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPK20_RS10390	COG3101	peptidyl-lysine hydroxylation
HPK20_RS10395	COG2860	membrane
HPK20_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS10405	COG0583	DNA-binding transcription factor activity
HPK20_RS10410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPK20_RS10415	COG2890	protein-(glutamine-N5) methyltransferase activity
HPK20_RS10420	COG2840	Smr protein MutS2
HPK20_RS10435	COG1987	bacterial-type flagellum assembly
HPK20_RS10485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPK20_RS10495	COG1677	Flagellar hook-basal body complex protein FliE
HPK20_RS10505	COG4191	Histidine kinase
HPK20_RS10515	COG1516	flagellar protein fliS
HPK20_RS10525	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPK20_RS10530	COG1334	flagellar protein FlaG
HPK20_RS10535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPK20_RS10540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPK20_RS10550	COG2837	iron assimilation
HPK20_RS10570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPK20_RS10580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK20_RS10590	COG1393	Belongs to the ArsC family
HPK20_RS10600	COG1876	peptidase activity
HPK20_RS10610	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPK20_RS10620	COG2716	regulation of RNA biosynthetic process
HPK20_RS10650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPK20_RS10670	COG3550	peptidyl-serine autophosphorylation
HPK20_RS10710	COG3621	Patatin-like phospholipase
HPK20_RS10715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPK20_RS10725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPK20_RS10745	COG4783	chaperone-mediated protein folding
HPK20_RS10750	COG1393	Belongs to the ArsC family
HPK20_RS10770	COG2233	PERMEase
HPK20_RS10780	COG0737	Belongs to the 5'-nucleotidase family
HPK20_RS10785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPK20_RS10790	COG2912	Transglutaminase-like superfamily
HPK20_RS10800	COG2890	protein-(glutamine-N5) methyltransferase activity
HPK20_RS10805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPK20_RS10810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPK20_RS10815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPK20_RS10825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPK20_RS10830	COG0193	aminoacyl-tRNA hydrolase activity
HPK20_RS10930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPK20_RS10945	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPK20_RS10945	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPK20_RS10950	COG1706	bacterial-type flagellum-dependent cell motility
HPK20_RS10955	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPK20_RS10965	COG4787	bacterial-type flagellum-dependent cell motility
HPK20_RS10985	COG1815	bacterial-type flagellum-dependent cell motility
HPK20_RS10990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPK20_RS10995	COG0835	chemotaxis
HPK20_RS10995	COG0784	Response regulator, receiver
HPK20_RS11005	COG2747	anti-sigma28 factor FlgM
HPK20_RS11040	COG2194	sulfuric ester hydrolase activity
HPK20_RS11045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPK20_RS11065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPK20_RS11070	COG2608	mercury ion transmembrane transporter activity
HPK20_RS11070	COG2217	Heavy metal translocating P-type atpase
HPK20_RS11100	COG2840	Smr protein MutS2
HPK20_RS11105	COG1187	pseudouridine synthase activity
HPK20_RS11110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPK20_RS11115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPK20_RS11120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPK20_RS11125	COG0121	glutamine amidotransferase
HPK20_RS11130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPK20_RS11135	COG1960	acyl-CoA dehydrogenase activity
HPK20_RS11145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPK20_RS11150	COG0328	RNA-DNA hybrid ribonuclease activity
HPK20_RS11155	COG2226	methyltransferase
HPK20_RS11165	COG1388	LysM domain
HPK20_RS11165	COG0741	lytic transglycosylase activity
HPK20_RS11175	COG3021	interspecies interaction between organisms
HPK20_RS11180	COG0347	Belongs to the P(II) protein family
HPK20_RS11190	COG0037	tRNA processing
HPK20_RS11195	COG0825	malonyl-CoA metabolic process
HPK20_RS11200	COG0587	DNA-directed DNA polymerase activity
HPK20_RS11205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPK20_RS11220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPK20_RS11225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPK20_RS11230	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPK20_RS11240	COG0750	zinc metalloprotease
HPK20_RS11245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPK20_RS11250	COG0575	Belongs to the CDS family
HPK20_RS11255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPK20_RS11270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPK20_RS11275	COG0052	Belongs to the universal ribosomal protein uS2 family
HPK20_RS11280	COG0024	Methionine aminopeptidase
HPK20_RS11285	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPK20_RS11295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPK20_RS11300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPK20_RS11305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPK20_RS11310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPK20_RS11325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPK20_RS11325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPK20_RS11330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPK20_RS11335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPK20_RS11340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPK20_RS11355	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPK20_RS11360	COG2252	PERMEase
HPK20_RS11365	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPK20_RS11375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPK20_RS11385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK20_RS11390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_RS11395	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK20_RS11400	COG4067	protein conserved in archaea
HPK20_RS11400	COG0189	ligase activity
HPK20_RS11405	COG0189	ligase activity
HPK20_RS11415	COG0733	neurotransmitter:sodium symporter activity
HPK20_RS11420	COG3706	GGDEF domain
HPK20_RS11420	COG4251	negative regulation of phosphorylation
HPK20_RS11420	COG5001	Diguanylate cyclase
HPK20_RS11420	COG2203	Gaf domain
HPK20_RS11430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPK20_RS11445	COG1477	protein flavinylation
HPK20_RS11450	COG2871	sodium ion transport
HPK20_RS11455	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPK20_RS11460	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPK20_RS11470	COG1805	sodium ion transport
HPK20_RS11475	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPK20_RS11480	COG0271	Belongs to the BolA IbaG family
HPK20_RS11565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPK20_RS11570	COG0590	tRNA wobble adenosine to inosine editing
HPK20_RS11580	COG0542	response to heat
HPK20_RS11590	COG0564	pseudouridine synthase activity
HPK20_RS11595	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_RS11600	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPK20_RS11605	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPK20_RS11610	COG1605	Chorismate mutase
HPK20_RS11610	COG0077	Prephenate dehydratase
HPK20_RS11615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPK20_RS11620	COG5001	Diguanylate cyclase
HPK20_RS11625	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HPK20_RS11630	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPK20_RS11640	COG0488	(ABC) transporter
HPK20_RS11650	COG0287	Prephenate dehydrogenase
HPK20_RS11650	COG1605	Chorismate mutase
HPK20_RS11655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPK20_RS11660	COG3275	phosphorelay sensor kinase activity
HPK20_RS11665	COG3279	Response regulator of the LytR AlgR family
HPK20_RS11675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPK20_RS11680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPK20_RS11695	COG1966	Carbon starvation protein
HPK20_RS11700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPK20_RS11705	COG1047	Peptidyl-prolyl cis-trans
HPK20_RS11710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPK20_RS11715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPK20_RS11720	COG0196	riboflavin kinase activity
HPK20_RS11725	COG0728	peptidoglycan biosynthetic process
HPK20_RS11730	COG0268	Binds directly to 16S ribosomal RNA
HPK20_RS11735	COG0640	Transcriptional regulator
HPK20_RS11740	COG0583	DNA-binding transcription factor activity
HPK20_RS11745	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPK20_RS11750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPK20_RS11760	COG0730	response to heat
HPK20_RS11770	COG0494	nUDIX hydrolase
HPK20_RS11785	COG0667	Aldo Keto reductase
HPK20_RS11795	COG2204	response regulator
HPK20_RS11800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPK20_RS11820	COG0513	Belongs to the DEAD box helicase family
HPK20_RS11845	COG3153	acetyltransferase
HPK20_RS11850	COG3154	lipid carrier protein
HPK20_RS11860	COG0826	peptidase U32
HPK20_RS11865	COG0826	peptidase U32
HPK20_RS11870	COG0534	Mate efflux family protein
HPK20_RS11890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPK20_RS11895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPK20_RS11900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPK20_RS11910	COG0195	Participates in both transcription termination and antitermination
HPK20_RS11915	COG0779	Required for maturation of 30S ribosomal subunits
HPK20_RS11930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPK20_RS11935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK20_RS11940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPK20_RS11945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPK20_RS11950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPK20_RS11955	COG1534	Rna-binding protein
HPK20_RS11960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPK20_RS11965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPK20_RS11970	COG2027	D-alanyl-D-alanine carboxypeptidase
HPK20_RS11975	COG2239	Acts as a magnesium transporter
HPK20_RS11985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPK20_RS11990	COG0739	heme binding
HPK20_RS12005	COG0316	Belongs to the HesB IscA family
HPK20_RS12010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPK20_RS12020	COG0628	permease
HPK20_RS12030	COG0784	Response regulator, receiver
HPK20_RS12030	COG2205	protein histidine kinase activity
HPK20_RS12035	COG0747	negative chemotaxis
HPK20_RS12045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK20_RS12050	COG0444	Belongs to the ABC transporter superfamily
HPK20_RS12055	COG4608	Belongs to the ABC transporter superfamily
HPK20_RS12065	COG2971	BadF BadG BcrA BcrD
HPK20_RS12080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK20_RS12085	COG3842	ATPase activity
HPK20_RS12095	COG1840	ABC-type Fe3 transport system, periplasmic component
HPK20_RS12100	COG0004	ammonium transporteR
HPK20_RS12105	COG0347	Belongs to the P(II) protein family
HPK20_RS12110	COG3112	Uncharacterised protein family (UPF0231)
HPK20_RS12115	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPK20_RS12120	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPK20_RS12125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK20_RS12130	COG1643	Atp-dependent helicase
HPK20_RS12135	COG1489	DNA binding
HPK20_RS12140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPK20_RS12145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPK20_RS12155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPK20_RS12160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPK20_RS12165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPK20_RS12170	COG0842	Transport permease protein
HPK20_RS12175	COG1131	(ABC) transporter
HPK20_RS12180	COG0288	reversible hydration of carbon dioxide
HPK20_RS12195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPK20_RS12200	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPK20_RS12205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPK20_RS12210	COG2186	Transcriptional regulator
HPK20_RS12215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPK20_RS12220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPK20_RS12225	COG4974	Belongs to the 'phage' integrase family
HPK20_RS12250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPK20_RS12255	COG1459	type II secretion system
HPK20_RS12270	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPK20_RS12285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPK20_RS12295	COG3150	esterase
HPK20_RS12305	COG3151	Protein conserved in bacteria
HPK20_RS12310	COG0494	nUDIX hydrolase
HPK20_RS12315	COG1538	Outer membrane efflux protein
HPK20_RS12325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPK20_RS12325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPK20_RS12330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPK20_RS12340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPK20_RS12345	COG3025	triphosphatase activity
HPK20_RS12350	COG1392	Phosphate transport regulator
HPK20_RS12355	COG0306	phosphate transporter
HPK20_RS12360	COG4991	sh3 domain protein
HPK20_RS12370	COG3409	Peptidoglycan-binding domain 1 protein
HPK20_RS12370	COG3267	Type II secretory pathway component ExeA
HPK20_RS12375	COG0617	tRNA 3'-terminal CCA addition
HPK20_RS12380	COG0148	phosphopyruvate hydratase activity
HPK20_RS12385	COG0504	CTP synthase activity
HPK20_RS12390	COG3956	TIGRFAM MazG family protein
HPK20_RS12395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPK20_RS12400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPK20_RS12410	COG0736	holo-[acyl-carrier-protein] synthase activity
HPK20_RS12415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPK20_RS12420	COG1381	Involved in DNA repair and RecF pathway recombination
HPK20_RS12425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPK20_RS12430	COG0571	ribonuclease III activity
HPK20_RS12440	COG0481	GTPase activity
HPK20_RS12445	COG3086	response to oxidative stress
HPK20_RS12460	COG1595	DNA-templated transcription, initiation
HPK20_RS12465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPK20_RS12475	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPK20_RS12495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPK20_RS12500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPK20_RS12505	COG3079	Belongs to the UPF0149 family
HPK20_RS12510	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPK20_RS12520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPK20_RS12530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_RS12535	COG0440	acetolactate synthase activity
HPK20_RS12540	COG0028	Belongs to the TPP enzyme family
HPK20_RS12545	COG1022	Amp-dependent synthetase and ligase
HPK20_RS12550	COG0583	DNA-binding transcription factor activity
HPK20_RS12575	COG0473	3-isopropylmalate dehydrogenase activity
HPK20_RS12580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPK20_RS12630	COG3437	response regulator, receiver
HPK20_RS12640	COG2200	EAL domain
HPK20_RS12640	COG2203	Gaf domain
HPK20_RS12640	COG2199	diguanylate cyclase activity
HPK20_RS12745	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPK20_RS12805	COG3706	GGDEF domain
HPK20_RS12815	COG0795	lipopolysaccharide-transporting ATPase activity
HPK20_RS12820	COG0795	lipopolysaccharide-transporting ATPase activity
HPK20_RS12825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPK20_RS12835	COG0525	valine-tRNA ligase activity
HPK20_RS12840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK20_RS12845	COG0564	pseudouridine synthase activity
HPK20_RS12855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPK20_RS12860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPK20_RS12865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPK20_RS12870	COG0540	Belongs to the ATCase OTCase family
HPK20_RS12880	COG0251	oxidation-reduction process
HPK20_RS12885	COG0204	Acyl-transferase
HPK20_RS12890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPK20_RS12895	COG5007	Belongs to the BolA IbaG family
HPK20_RS12900	COG3113	response to antibiotic
HPK20_RS12905	COG2854	intermembrane phospholipid transfer
HPK20_RS12910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPK20_RS12915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPK20_RS12920	COG1127	ABC transporter
HPK20_RS12930	COG0517	IMP dehydrogenase activity
HPK20_RS12930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPK20_RS12935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPK20_RS12945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPK20_RS12950	COG1137	ATPase activity
HPK20_RS12960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPK20_RS12965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS12970	COG1660	Displays ATPase and GTPase activities
HPK20_RS12975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS12980	COG2239	Acts as a magnesium transporter
HPK20_RS12985	COG0312	modulator of DNA gyrase
HPK20_RS12990	COG3028	Belongs to the UPF0307 family
HPK20_RS12995	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPK20_RS13000	COG1178	ABC-type Fe3 transport system permease component
HPK20_RS13010	COG0163	prenyltransferase activity
HPK20_RS13015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPK20_RS13020	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPK20_RS13025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPK20_RS13030	COG2105	PFAM AIG2 family protein
HPK20_RS13040	COG0729	surface antigen
HPK20_RS13045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_RS13050	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPK20_RS13065	COG0577	efflux transmembrane transporter activity
HPK20_RS13065	COG1136	(ABC) transporter
HPK20_RS13085	COG0529	Catalyzes the synthesis of activated sulfate
HPK20_RS13090	COG0490	domain, Protein
HPK20_RS13090	COG0471	metal ion transport
HPK20_RS13095	COG2895	sulfate adenylyltransferase (ATP) activity
HPK20_RS13100	COG0175	sulfate reduction
HPK20_RS13105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPK20_RS13105	COG1648	precorrin-2 dehydrogenase activity
HPK20_RS13110	COG0737	Belongs to the 5'-nucleotidase family
HPK20_RS13120	COG0513	Belongs to the DEAD box helicase family
HPK20_RS13125	COG2153	protein acetylation
HPK20_RS13130	COG0697	spore germination
HPK20_RS13135	COG3061	Opacity-associated protein A
HPK20_RS13140	COG0545	Peptidyl-prolyl cis-trans isomerase
HPK20_RS13150	COG0203	ribosomal protein L17
HPK20_RS13155	COG0202	RNA polymerase activity
HPK20_RS13160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPK20_RS13165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPK20_RS13170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPK20_RS13175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPK20_RS13180	COG0201	protein transport
HPK20_RS13190	COG1841	ribosomal large subunit assembly
HPK20_RS13200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPK20_RS13210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPK20_RS13215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPK20_RS13220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPK20_RS13225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPK20_RS13230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPK20_RS13235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPK20_RS13240	COG0255	Belongs to the universal ribosomal protein uL29 family
HPK20_RS13245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPK20_RS13255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPK20_RS13260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPK20_RS13265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPK20_RS13270	COG0089	rRNA binding
HPK20_RS13275	COG0088	Forms part of the polypeptide exit tunnel
HPK20_RS13280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPK20_RS13285	COG0051	transcription antitermination factor activity, RNA binding
HPK20_RS13290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPK20_RS13295	COG0557	exoribonuclease II activity
HPK20_RS13300	COG3083	sulfuric ester hydrolase activity
HPK20_RS13305	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPK20_RS13310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPK20_RS13320	COG1047	Peptidyl-prolyl cis-trans
HPK20_RS13325	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HPK20_RS13335	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPK20_RS13340	COG0488	(ABC) transporter
HPK20_RS13350	COG0429	hydrolase of the alpha beta-hydrolase fold
HPK20_RS13360	COG3954	Phosphoribulokinase
HPK20_RS13375	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_RS13385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPK20_RS13395	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPK20_RS13405	COG0180	Tryptophanyl-tRNA synthetase
HPK20_RS13415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPK20_RS13420	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPK20_RS13430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPK20_RS13465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPK20_RS13475	COG0678	peroxiredoxin activity
HPK20_RS13475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPK20_RS13485	COG0165	Argininosuccinate lyase
HPK20_RS13485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPK20_RS13490	COG0137	argininosuccinate synthase activity
HPK20_RS13495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPK20_RS13500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPK20_RS13505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK20_RS13510	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPK20_RS13515	COG1695	Transcriptional regulator
HPK20_RS13520	COG1045	serine acetyltransferase
HPK20_RS13525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPK20_RS13530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPK20_RS13535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK20_RS13540	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPK20_RS13545	COG1053	succinate dehydrogenase
HPK20_RS13550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPK20_RS13555	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPK20_RS13565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPK20_RS13570	COG1509	lysine 2,3-aminomutase activity
HPK20_RS13575	COG1285	pathogenesis
HPK20_RS13585	COG1119	ATPase activity
HPK20_RS13590	COG0459	protein refolding
HPK20_RS13620	COG0149	triose-phosphate isomerase activity
HPK20_RS13625	COG0534	Mate efflux family protein
HPK20_RS13630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPK20_RS13635	COG1575	Belongs to the MenA family. Type 1 subfamily
HPK20_RS13640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPK20_RS13645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPK20_RS13655	COG1609	Transcriptional regulator
HPK20_RS13660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPK20_RS13665	COG0254	rRNA binding
HPK20_RS13670	COG0281	malic enzyme
HPK20_RS13675	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPK20_RS13680	COG0626	cystathionine gamma-synthase activity
HPK20_RS13685	COG0460	homoserine dehydrogenase
HPK20_RS13685	COG0527	aspartate kinase activity
HPK20_RS13690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPK20_RS13700	COG1494	fructose-1,6-bisphosphatase
HPK20_RS13705	COG0205	6-phosphofructokinase activity
HPK20_RS13710	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK20_RS13720	COG0745	RESPONSE REGULATOR receiver
HPK20_RS13725	COG2205	protein histidine kinase activity
HPK20_RS13730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPK20_RS13735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPK20_RS13740	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPK20_RS13745	COG3706	GGDEF domain
HPK20_RS13750	COG1027	Aspartate ammonia-lyase
HPK20_RS13755	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPK20_RS13760	COG1288	antiporter activity
HPK20_RS13775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPK20_RS13780	COG0540	Belongs to the ATCase OTCase family
HPK20_RS13785	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HPK20_RS13795	COG4232	protein-disulfide reductase activity
HPK20_RS13815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK20_RS13820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPK20_RS13825	COG0194	GDP metabolic process
HPK20_RS13830	COG1758	RNA polymerase activity
HPK20_RS13835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPK20_RS13840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPK20_RS13845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPK20_RS13850	COG2233	PERMEase
HPK20_RS13855	COG2205	protein histidine kinase activity
HPK20_RS13860	COG0745	RESPONSE REGULATOR receiver
HPK20_RS13865	COG0800	Aldolase
HPK20_RS13870	COG2610	gluconate transmembrane transporter activity
HPK20_RS13875	COG3265	gluconokinase activity
HPK20_RS13880	COG0129	dihydroxy-acid dehydratase activity
HPK20_RS13885	COG1609	Transcriptional regulator
HPK20_RS13890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPK20_RS13900	COG2183	response to ionizing radiation
HPK20_RS13915	COG1040	competence protein
HPK20_RS13925	COG0494	nUDIX hydrolase
HPK20_RS13930	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPK20_RS13940	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPK20_RS13945	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPK20_RS13950	COG3156	type II secretion system protein K
HPK20_RS13955	COG4795	General secretion pathway protein
HPK20_RS13960	COG2165	general secretion pathway protein
HPK20_RS13965	COG2165	general secretion pathway protein
HPK20_RS13970	COG2165	general secretion pathway protein
HPK20_RS13975	COG1459	type II secretion system
HPK20_RS13980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPK20_RS13990	COG3031	protein transport across the cell outer membrane
HPK20_RS13995	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPK20_RS14000	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPK20_RS14005	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPK20_RS14010	COG2982	Protein involved in outer membrane biogenesis
HPK20_RS14015	COG0456	acetyltransferase
HPK20_RS14020	COG1490	D-aminoacyl-tRNA deacylase activity
HPK20_RS14045	COG0174	glutamine synthetase
HPK20_RS14055	COG3852	Histidine kinase
HPK20_RS14060	COG2204	response regulator
HPK20_RS14065	COG3300	MHYT domain
HPK20_RS14065	COG5001	Diguanylate cyclase
HPK20_RS14070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPK20_RS14130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPK20_RS14145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPK20_RS14160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPK20_RS14165	COG0534	Mate efflux family protein
HPK20_RS14175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPK20_RS14180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPK20_RS14185	COG2937	Belongs to the GPAT DAPAT family
HPK20_RS14190	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPK20_RS14195	COG3161	chorismate lyase activity
HPK20_RS14200	COG1580	Controls the rotational direction of flagella during chemotaxis
HPK20_RS14205	COG0705	Rhomboid family
HPK20_RS14210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK20_RS14215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPK20_RS14220	COG2177	Part of the ABC transporter FtsEX involved in
HPK20_RS14225	COG2884	Cell division ATP-binding protein ftsE
HPK20_RS14230	COG0552	protein localization to endoplasmic reticulum
HPK20_RS14235	COG0742	ribosomal rna small subunit methyltransferase
HPK20_RS14245	COG2095	MarC family integral membrane protein
HPK20_RS14275	COG0783	Belongs to the Dps family
HPK20_RS14290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK20_RS14295	COG0640	Transcriptional regulator
HPK20_RS14300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPK20_RS14305	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS14310	COG2267	carboxylic ester hydrolase activity
HPK20_RS14315	COG0561	phosphatase activity
HPK20_RS14335	COG3287	FIST C domain
HPK20_RS14335	COG2199	diguanylate cyclase activity
HPK20_RS14335	COG2200	EAL domain
HPK20_RS14340	COG1011	Hydrolase
HPK20_RS14345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPK20_RS14355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPK20_RS14360	COG0019	diaminopimelate decarboxylase activity
HPK20_RS14370	COG1965	Belongs to the frataxin family
HPK20_RS14375	COG3072	Adenylate cyclase
HPK20_RS14390	COG2959	enzyme of heme biosynthesis
HPK20_RS14395	COG3071	HemY protein
HPK20_RS14400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPK20_RS14430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK20_RS14430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK20_RS14445	COG0084	hydrolase, TatD family'
HPK20_RS14450	COG0805	protein transport
HPK20_RS14455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPK20_RS14465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPK20_RS14470	COG3165	ubiquinone biosynthetic process from chorismate
HPK20_RS14475	COG2226	methyltransferase
HPK20_RS14480	COG1322	Protein conserved in bacteria
HPK20_RS14505	COG2160	L-arabinose isomerase activity
HPK20_RS14510	COG0235	Class ii aldolase
HPK20_RS14515	COG1069	ribulokinase activity
HPK20_RS14520	COG1879	ABC-type sugar transport system periplasmic component
HPK20_RS14525	COG1129	ABC transporter
HPK20_RS14530	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPK20_RS14535	COG2081	HI0933 family
HPK20_RS14545	COG1528	Iron-storage protein
HPK20_RS14550	COG0589	response to stress
HPK20_RS14555	COG0697	spore germination
HPK20_RS14570	COG5001	Diguanylate cyclase
HPK20_RS14570	COG5002	protein histidine kinase activity
HPK20_RS14575	COG1522	sequence-specific DNA binding
HPK20_RS14595	COG0006	proline dipeptidase activity
HPK20_RS14595	COG0006	proline dipeptidase activity
HPK20_RS14625	COG0517	IMP dehydrogenase activity
HPK20_RS14625	COG4175	Glycine betaine
HPK20_RS14640	COG2104	thiamine diphosphate biosynthetic process
HPK20_RS14640	COG2022	thiamine diphosphate biosynthetic process
HPK20_RS14645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPK20_RS14650	COG0352	thiamine-phosphate diphosphorylase activity
HPK20_RS14655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPK20_RS14660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPK20_RS14665	COG2132	Multicopper oxidase
HPK20_RS14720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPK20_RS14725	COG1739	Uncharacterized protein family UPF0029
HPK20_RS14735	COG0183	Belongs to the thiolase family
HPK20_RS14740	COG0583	DNA-binding transcription factor activity
HPK20_RS14745	COG2814	Major facilitator Superfamily
HPK20_RS14750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_RS14755	COG0765	amino acid transport
HPK20_RS14765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPK20_RS14770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPK20_RS14775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPK20_RS14780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPK20_RS14785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPK20_RS14790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPK20_RS14805	COG3312	ion transport
HPK20_RS14810	COG1475	DNA binding
HPK20_RS14815	COG1192	Involved in chromosome partitioning
HPK20_RS14820	COG0357	Ribosomal RNA small subunit methyltransferase G
HPK20_RS14825	COG0445	tRNA wobble uridine modification
HPK20_RS14830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPK20_RS14835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPK20_RS14840	COG0706	membrane insertase activity
HPK20_RS14855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPK20_RS14860	COG1126	abc transporter atp-binding protein
HPK20_RS14880	COG2433	Pfam Transposase IS66
HPK20_RS14975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK20_RS14990	COG2017	converts alpha-aldose to the beta-anomer
HPK20_RS14995	COG1609	Transcriptional regulator
HPK20_RS15020	COG2186	Transcriptional regulator
HPK20_RS15025	COG2731	YhcH YjgK YiaL family protein
HPK20_RS15040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPK20_RS15045	COG1063	alcohol dehydrogenase
HPK20_RS15050	COG0246	Mannitol dehydrogenase
HPK20_RS15060	COG0800	Aldolase
HPK20_RS15065	COG4948	Mandelate Racemase Muconate Lactonizing
HPK20_RS15095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_RS15105	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK20_RS15125	COG0148	phosphopyruvate hydratase activity
HPK20_RS15155	COG0395	ABC-type sugar transport system, permease component
HPK20_RS15160	COG1175	transmembrane transport
HPK20_RS15175	COG2186	Transcriptional regulator
HPK20_RS15180	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_RS15195	COG2814	Major facilitator Superfamily
HPK20_RS15200	COG3547	Transposase (IS116 IS110 IS902 family)
HPK20_RS15215	COG3250	beta-galactosidase activity
HPK20_RS15225	COG4580	involved in the transport of maltose and maltodextrins
HPK20_RS15245	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK20_RS15255	COG1609	Transcriptional regulator
HPK20_RS15265	COG1929	Belongs to the glycerate kinase type-1 family
HPK20_RS15270	COG0383	alpha-mannosidase activity
HPK20_RS15275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS15275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS15275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS15280	COG2188	Transcriptional regulator
HPK20_RS15300	COG0371	Dehydrogenase
HPK20_RS15475	COG4974	Belongs to the 'phage' integrase family
HPK20_RS15490	COG3132	Protein of unknown function, DUF480
HPK20_RS15495	COG2827	Endonuclease containing a URI domain
HPK20_RS15505	COG1879	ABC-type sugar transport system periplasmic component
HPK20_RS15510	COG0784	Response regulator, receiver
HPK20_RS15510	COG5002	protein histidine kinase activity
HPK20_RS15530	COG1492	cobalamin metabolic process
HPK20_RS15535	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPK20_RS15540	COG4149	molybdate abc transporter
HPK20_RS15545	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPK20_RS15565	COG1289	transmembrane transporter activity
HPK20_RS15705	COG0210	DNA helicase
HPK20_RS15710	COG1335	isochorismatase
HPK20_RS15715	COG1803	Methylglyoxal synthase
HPK20_RS15720	COG1879	ABC-type sugar transport system periplasmic component
HPK20_RS15725	COG2198	Histidine kinase
HPK20_RS15725	COG0784	Response regulator, receiver
HPK20_RS15725	COG2205	protein histidine kinase activity
HPK20_RS15730	COG0469	pyruvate kinase activity
HPK20_RS15735	COG2271	Major facilitator Superfamily
HPK20_RS15760	COG1979	alcohol dehydrogenase
HPK20_RS15765	COG2207	Transcriptional regulator
HPK20_RS15780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPK20_RS15785	COG3706	GGDEF domain
HPK20_RS15805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK20_RS15810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK20_RS15820	COG0183	Belongs to the thiolase family
HPK20_RS15860	COG0243	molybdopterin cofactor binding
HPK20_RS15875	COG3850	Histidine kinase
HPK20_RS15880	COG2197	response regulator
HPK20_RS15885	COG3069	C4-dicarboxylate transmembrane transporter activity
HPK20_RS15900	COG2814	Major facilitator Superfamily
HPK20_RS15910	COG0840	transmembrane signaling receptor activity
HPK20_RS15915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK20_RS15920	COG0545	Peptidyl-prolyl cis-trans isomerase
HPK20_RS15935	COG0840	transmembrane signaling receptor activity
HPK20_RS15940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPK20_RS15955	COG2897	thiosulfate sulfurtransferase activity
HPK20_RS15960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPK20_RS15970	COG0302	gtp cyclohydrolase
HPK20_RS15975	COG0531	amino acid
HPK20_RS15985	COG4303	Ethanolamine ammonia lyase large subunit
HPK20_RS15990	COG2207	Transcriptional regulator
HPK20_RS15995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_RS15995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_RS16000	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPK20_RS16005	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPK20_RS16020	COG1011	Hydrolase
HPK20_RS16025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPK20_RS16045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPK20_RS16055	COG3842	ATPase activity
HPK20_RS16075	COG2866	Carboxypeptidase
HPK20_RS16100	COG4166	transmembrane transport
HPK20_RS16105	COG4174	ABC transporter (Permease)
HPK20_RS16110	COG4239	(ABC) transporter, permease
HPK20_RS16115	COG4172	Belongs to the ABC transporter superfamily
HPK20_RS16120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPK20_RS16150	COG3706	GGDEF domain
HPK20_RS16165	COG2501	S4 domain
HPK20_RS16230	COG1979	alcohol dehydrogenase
HPK20_RS16235	COG2207	Transcriptional regulator
HPK20_RS16255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPK20_RS16265	COG0488	(ABC) transporter
HPK20_RS16275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPK20_RS16285	COG2814	Major facilitator Superfamily
HPK20_RS16305	COG3710	Transcriptional regulator
HPK20_RS16335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_RS16350	COG2233	PERMEase
HPK20_RS16370	COG1953	Uracil, thiamine, allantoin
HPK20_RS16380	COG0765	amino acid transport
HPK20_RS16385	COG0765	amino acid transport
HPK20_RS16415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPK20_RS16440	COG0402	S-adenosylhomocysteine deaminase activity
HPK20_RS16445	COG2351	hydroxyisourate hydrolase activity
HPK20_RS16485	COG1129	ABC transporter
HPK20_RS16490	COG1309	transcriptional regulator
HPK20_RS16500	COG3706	GGDEF domain
HPK20_RS16525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPK20_RS16530	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPK20_RS16540	COG0745	RESPONSE REGULATOR receiver
HPK20_RS16555	COG3140	Belongs to the UPF0181 family
HPK20_RS16620	COG0023	Translation Initiation Factor
HPK20_RS16645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK20_RS16645	COG1042	CoA-binding domain protein
HPK20_RS16645	COG0045	succinate-CoA ligase (ADP-forming) activity
HPK20_RS16650	COG0583	DNA-binding transcription factor activity
HPK20_RS16655	COG4771	TonB-dependent receptor
HPK20_RS16655	COG1629	transport
HPK20_RS16675	COG2050	protein possibly involved in aromatic compounds catabolism
HPK20_RS16680	COG0501	Belongs to the peptidase M48B family
HPK20_RS16685	COG2824	Alkylphosphonate utilization operon protein PhnA
HPK20_RS16695	COG0861	Integral membrane protein TerC family
HPK20_RS16700	COG0737	Belongs to the 5'-nucleotidase family
HPK20_RS16705	COG3593	DNA synthesis involved in DNA repair
HPK20_RS16715	COG0583	DNA-binding transcription factor activity
HPK20_RS16720	COG2116	formate transmembrane transporter activity
HPK20_RS16725	COG2353	YceI-like domain
HPK20_RS16730	COG3038	cytochrome b561
HPK20_RS16755	COG5001	Diguanylate cyclase
HPK20_RS16765	COG0243	molybdopterin cofactor binding
HPK20_RS16770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPK20_RS16780	COG0784	Response regulator, receiver
HPK20_RS16780	COG2205	protein histidine kinase activity
HPK20_RS16780	COG5002	protein histidine kinase activity
HPK20_RS16785	COG3437	response regulator, receiver
HPK20_RS16795	COG2207	Transcriptional regulator
HPK20_RS16800	COG0582	viral genome integration into host DNA
HPK20_RS16815	COG2203	Gaf domain
HPK20_RS16815	COG3706	GGDEF domain
HPK20_RS16815	COG5001	Diguanylate cyclase
HPK20_RS16815	COG4251	negative regulation of phosphorylation
HPK20_RS16850	COG2181	nitrate reductase activity
HPK20_RS16855	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPK20_RS16860	COG1140	nitrate reductase beta subunit
HPK20_RS16865	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPK20_RS16870	COG2223	nitrite transmembrane transporter activity
HPK20_RS16875	COG3850	Histidine kinase
HPK20_RS16880	COG2197	response regulator
HPK20_RS16885	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPK20_RS16890	COG2239	Acts as a magnesium transporter
HPK20_RS16895	COG3290	protein histidine kinase activity
HPK20_RS16895	COG0840	transmembrane signaling receptor activity
HPK20_RS16945	COG1518	maintenance of DNA repeat elements
HPK20_RS16970	COG2003	Belongs to the UPF0758 family
HPK20_RS17000	COG1160	GTP binding
HPK20_RS17015	COG0328	RNA-DNA hybrid ribonuclease activity
HPK20_RS17060	COG3501	Rhs element vgr protein
HPK20_RS17080	COG0523	cobalamin synthesis protein
HPK20_RS17095	COG0156	8-amino-7-oxononanoate synthase activity
HPK20_RS17100	COG2205	protein histidine kinase activity
HPK20_RS17100	COG0784	Response regulator, receiver
HPK20_RS17105	COG0419	ATPase involved in DNA repair
HPK20_RS17115	COG1609	Transcriptional regulator
HPK20_RS17120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS17120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS17125	COG1105	Belongs to the carbohydrate kinase PfkB family
HPK20_RS17130	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPK20_RS17130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS17130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS17135	COG4067	protein conserved in archaea
HPK20_RS17135	COG0189	ligase activity
HPK20_RS17145	COG0602	queuosine metabolic process
HPK20_RS17150	COG1328	CTP reductase activity
HPK20_RS17210	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS17215	COG0745	RESPONSE REGULATOR receiver
HPK20_RS17225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPK20_RS17235	COG0583	DNA-binding transcription factor activity
HPK20_RS17250	COG1309	transcriptional regulator
HPK20_RS17255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_RS17285	COG1335	isochorismatase
HPK20_RS17290	COG4977	sequence-specific DNA binding
HPK20_RS17295	COG0456	acetyltransferase
HPK20_RS17305	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS17310	COG0494	nUDIX hydrolase
HPK20_RS17320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPK20_RS17350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK20_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS17380	COG0454	-acetyltransferase
HPK20_RS17440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPK20_RS17445	COG0789	Transcriptional regulator
HPK20_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS17515	COG4628	conserved protein (DUF2132)
HPK20_RS17535	COG0672	)-iron permease
HPK20_RS17555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPK20_RS17560	COG0513	Belongs to the DEAD box helicase family
HPK20_RS17575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK20_RS17585	COG0583	DNA-binding transcription factor activity
HPK20_RS17600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS17605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS17615	COG2207	Transcriptional regulator
HPK20_RS17620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS17620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS17620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS17630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS17655	COG1538	Outer membrane efflux protein
HPK20_RS17665	COG1132	(ABC) transporter
HPK20_RS17680	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPK20_RS17690	COG1349	DNA-binding transcription factor activity
HPK20_RS17695	COG0110	maltose O-acetyltransferase activity
HPK20_RS17700	COG3706	GGDEF domain
HPK20_RS17710	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPK20_RS17715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPK20_RS17735	COG0747	negative chemotaxis
HPK20_RS17740	COG4172	Belongs to the ABC transporter superfamily
HPK20_RS17750	COG3437	response regulator, receiver
HPK20_RS17755	COG2205	protein histidine kinase activity
HPK20_RS17755	COG2198	Histidine kinase
HPK20_RS17755	COG0784	Response regulator, receiver
HPK20_RS17765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPK20_RS17790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_RS17805	COG2423	ornithine cyclodeaminase activity
HPK20_RS17815	COG4145	pantothenate transmembrane transporter activity
HPK20_RS17820	COG0583	DNA-binding transcription factor activity
HPK20_RS17825	COG0435	Glutathione S-transferase
HPK20_RS17830	COG0400	carboxylic ester hydrolase activity
HPK20_RS17835	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS17850	COG1473	amidohydrolase
HPK20_RS17870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_RS17875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK20_RS17880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPK20_RS17890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPK20_RS17905	COG2721	sulfolactate sulfo-lyase activity
HPK20_RS17960	COG0625	glutathione transferase activity
HPK20_RS17970	COG1472	Belongs to the glycosyl hydrolase 3 family
HPK20_RS17980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPK20_RS17990	COG0573	inorganic phosphate transmembrane transporter activity
HPK20_RS17995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK20_RS18015	COG1464	Belongs to the NlpA lipoprotein family
HPK20_RS18020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK20_RS18020	COG0512	Glutamine amidotransferase of anthranilate synthase
HPK20_RS18040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_RS18055	COG0653	protein targeting
HPK20_RS18075	COG2814	Major facilitator Superfamily
HPK20_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS18095	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS18105	COG1024	Enoyl-CoA hydratase
HPK20_RS18110	COG1024	Enoyl-CoA hydratase
HPK20_RS18115	COG1960	acyl-CoA dehydrogenase activity
HPK20_RS18125	COG0183	Belongs to the thiolase family
HPK20_RS18135	COG1960	acyl-CoA dehydrogenase activity
HPK20_RS18140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPK20_RS18145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPK20_RS18160	COG0450	alkyl hydroperoxide reductase
HPK20_RS18165	COG3634	alkyl hydroperoxide reductase activity
HPK20_RS18195	COG1609	Transcriptional regulator
HPK20_RS18195	COG2207	Transcriptional regulator
HPK20_RS18200	COG1454	alcohol dehydrogenase
HPK20_RS18205	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK20_RS18245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPK20_RS18260	COG1609	Transcriptional regulator
HPK20_RS18260	COG2207	Transcriptional regulator
HPK20_RS18265	COG4604	ABC transporter, ATP-binding protein
HPK20_RS18270	COG4605	iron ion homeostasis
HPK20_RS18275	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_RS18300	COG5380	lipid catabolic process
HPK20_RS18305	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPK20_RS18315	COG1522	sequence-specific DNA binding
HPK20_RS18335	COG2814	Major facilitator Superfamily
HPK20_RS18345	COG0840	transmembrane signaling receptor activity
HPK20_RS18360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPK20_RS18365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPK20_RS18370	COG3279	Response regulator of the LytR AlgR family
HPK20_RS18375	COG3275	phosphorelay sensor kinase activity
HPK20_RS18380	COG4989	oxidoreductase activity
HPK20_RS18395	COG0366	Alpha amylase catalytic
HPK20_RS18400	COG3227	Zinc metalloprotease (Elastase)
HPK20_RS18405	COG3047	cAMP biosynthetic process
HPK20_RS18410	COG0071	Belongs to the small heat shock protein (HSP20) family
HPK20_RS18425	COG0251	oxidation-reduction process
HPK20_RS18450	COG1132	(ABC) transporter
HPK20_RS18455	COG1132	(ABC) transporter
HPK20_RS18465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HPK20_RS18470	COG2246	polysaccharide biosynthetic process
HPK20_RS18485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK20_RS18495	COG0242	peptide deformylase activity
HPK20_RS18505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_RS18510	COG2084	Dehydrogenase
HPK20_RS18520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPK20_RS18525	COG0583	DNA-binding transcription factor activity
HPK20_RS18570	COG1063	alcohol dehydrogenase
HPK20_RS18575	COG0156	8-amino-7-oxononanoate synthase activity
HPK20_RS18580	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_RS18585	COG3284	Transcriptional regulator
HPK20_RS18595	COG0346	lactoylglutathione lyase activity
HPK20_RS18615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPK20_RS18625	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK20_RS18630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPK20_RS18635	COG0363	glucosamine-6-phosphate deaminase activity
HPK20_RS18640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPK20_RS18655	COG0583	DNA-binding transcription factor activity
HPK20_RS18670	COG1410	methionine synthase
HPK20_RS18670	COG0646	methionine synthase
HPK20_RS18675	COG0531	amino acid
HPK20_RS18690	COG1473	amidohydrolase
HPK20_RS18695	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPK20_RS18700	COG1929	Belongs to the glycerate kinase type-1 family
HPK20_RS18705	COG2610	gluconate transmembrane transporter activity
HPK20_RS18710	COG3835	regulator
HPK20_RS18715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK20_RS18720	COG4533	DNA binding
HPK20_RS18735	COG0840	transmembrane signaling receptor activity
HPK20_RS18795	COG4964	Belongs to the GSP D family
HPK20_RS18835	COG0798	PFAM Bile acid sodium symporter
HPK20_RS18860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK20_RS18865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPK20_RS18865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPK20_RS18875	COG0745	RESPONSE REGULATOR receiver
HPK20_RS18900	COG1278	Cold shock
HPK20_RS18905	COG4681	YaeQ
HPK20_RS18910	COG3706	GGDEF domain
HPK20_RS18915	COG1017	nitric oxide dioxygenase activity
HPK20_RS18915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPK20_RS18920	COG3604	Transcriptional regulator
HPK20_RS18930	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK20_RS18935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK20_RS18945	COG0366	Alpha amylase catalytic
HPK20_RS18965	COG0714	Associated with various cellular activities
HPK20_RS18985	COG2304	oxidoreductase activity
HPK20_RS19010	COG0784	Response regulator, receiver
HPK20_RS19010	COG2205	protein histidine kinase activity
HPK20_RS19010	COG5002	protein histidine kinase activity
HPK20_RS19025	COG3724	N-succinylarginine dihydrolase activity
HPK20_RS19030	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_RS19055	COG4948	Mandelate Racemase Muconate Lactonizing
HPK20_RS19080	COG0583	DNA-binding transcription factor activity
HPK20_RS19105	COG3171	Protein conserved in bacteria
HPK20_RS19110	COG0589	response to stress
HPK20_RS19120	COG3530	Putative quorum-sensing-regulated virulence factor
HPK20_RS19130	COG0579	oxidoreductase
HPK20_RS19145	COG2204	response regulator
HPK20_RS19155	COG1929	Belongs to the glycerate kinase type-1 family
HPK20_RS19160	COG0383	alpha-mannosidase activity
HPK20_RS19165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS19165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_RS19165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS19170	COG2188	Transcriptional regulator
HPK20_RS19195	COG5001	Diguanylate cyclase
HPK20_RS19195	COG3300	MHYT domain
HPK20_RS19200	COG2271	Major facilitator Superfamily
HPK20_RS19205	COG0584	glycerophosphoryl diester phosphodiesterase
HPK20_RS19210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPK20_RS19215	COG0583	DNA-binding transcription factor activity
HPK20_RS19225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_RS19230	COG1879	ABC-type sugar transport system periplasmic component
HPK20_RS19235	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPK20_RS19240	COG1129	ABC transporter
HPK20_RS19245	COG1869	D-ribose catabolic process
HPK20_RS19260	COG3501	Rhs element vgr protein
HPK20_RS19355	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS19360	COG1846	Transcriptional regulator
HPK20_RS19375	COG0564	pseudouridine synthase activity
HPK20_RS19380	COG1309	transcriptional regulator
HPK20_RS19385	COG2130	NADP-dependent
HPK20_RS19400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK20_RS19420	COG1177	transmembrane transport
HPK20_RS19430	COG3842	ATPase activity
HPK20_RS19440	COG2200	EAL domain
HPK20_RS19445	COG0656	L-ascorbic acid biosynthetic process
HPK20_RS19450	COG1902	pentaerythritol trinitrate reductase activity
HPK20_RS19455	COG0583	DNA-binding transcription factor activity
HPK20_RS19460	COG2814	Major facilitator Superfamily
HPK20_RS19480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK20_RS19495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPK20_RS19505	COG4702	Belongs to the UPF0303 family
HPK20_RS19510	COG0673	inositol 2-dehydrogenase activity
HPK20_RS19515	COG1349	DNA-binding transcription factor activity
HPK20_RS19520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPK20_RS19540	COG3240	lipase activity
HPK20_RS19545	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_RS19560	COG1120	ATPase activity
HPK20_RS19565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_RS19570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_RS19575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPK20_RS19580	COG4774	siderophore transport
HPK20_RS19605	COG0840	transmembrane signaling receptor activity
HPK20_RS19610	COG3384	dioxygenase
HPK20_RS19615	COG0583	DNA-binding transcription factor activity
HPK20_RS19625	COG1342	Belongs to the UPF0251 family
HPK20_RS19630	COG0778	Nitroreductase
HPK20_RS19635	COG0583	DNA-binding transcription factor activity
HPK20_RS19645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_RS19650	COG0697	spore germination
HPK20_RS19665	COG2814	Major facilitator Superfamily
HPK20_RS19670	COG0583	DNA-binding transcription factor activity
HPK20_RS19675	COG5001	Diguanylate cyclase
HPK20_RS19675	COG3300	MHYT domain
HPK20_RS19680	COG0739	heme binding
HPK20_RS19695	COG0659	secondary active sulfate transmembrane transporter activity
HPK20_RS19710	COG2199	diguanylate cyclase activity
HPK20_RS19715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPK20_RS19720	COG0581	inorganic phosphate transmembrane transporter activity
HPK20_RS19725	COG0573	inorganic phosphate transmembrane transporter activity
HPK20_RS19730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK20_RS19735	COG0840	transmembrane signaling receptor activity
HPK20_RS19740	COG0513	Belongs to the DEAD box helicase family
HPK20_RS19750	COG1388	LysM domain
HPK20_RS19750	COG1376	ErfK ybiS ycfS ynhG family protein
HPK20_RS19755	COG0415	Belongs to the DNA photolyase family
HPK20_RS19765	COG3272	Protein of unknown function (DUF1722)
HPK20_RS19770	COG0813	purine-nucleoside phosphorylase activity
HPK20_RS19785	COG3706	GGDEF domain
HPK20_RS19795	COG1566	PFAM secretion protein HlyD family protein
HPK20_RS19830	COG0786	glutamate:sodium symporter activity
HPK20_RS19845	COG1999	signal sequence binding
HPK20_RS19855	COG1162	GTPase activity
HPK20_RS19860	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPK20_RS19875	COG4580	involved in the transport of maltose and maltodextrins
HPK20_RS19895	COG1132	(ABC) transporter
HPK20_RS19905	COG0671	phosphoesterase, PA-phosphatase related
HPK20_RS19915	COG3383	formate dehydrogenase (NAD+) activity
HPK20_RS19930	COG0840	transmembrane signaling receptor activity
HPK20_RS19940	COG1131	(ABC) transporter
HPK20_RS19945	COG2188	Transcriptional regulator
HPK20_RS19955	COG3033	Beta-eliminating lyase
HPK20_RS19960	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPK20_RS19965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK20_RS19975	COG0471	metal ion transport
HPK20_RS20020	COG3501	Rhs element vgr protein
HPK20_RS20030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPK20_RS20035	COG1640	4-alpha-glucanotransferase
HPK20_RS20040	COG0058	SHG alpha-glucan phosphorylase activity
HPK20_RS20045	COG2909	trisaccharide binding
HPK20_RS20060	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPK20_RS20065	COG1845	cytochrome c oxidase, subunit III
HPK20_RS20070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK20_RS20075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPK20_RS20090	COG2084	Dehydrogenase
HPK20_RS20105	COG0217	transcriptional regulatory protein
HPK20_RS20140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPK20_RS20145	COG1444	tRNA N-acetyltransferase activity
HPK20_RS20160	COG0643	Histidine kinase
HPK20_RS20160	COG2198	Histidine kinase
HPK20_RS20170	COG0835	chemotaxis
HPK20_RS20175	COG0840	transmembrane signaling receptor activity
HPK20_RS20180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPK20_RS20190	COG2201	protein-glutamate methylesterase activity
HPK20_RS20205	COG0745	RESPONSE REGULATOR receiver
HPK20_RS20245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPK20_RS20280	COG0840	transmembrane signaling receptor activity
HPK20_RS20300	COG0513	Belongs to the DEAD box helicase family
HPK20_RS20310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_RS20315	COG4597	amino acid ABC transporter
HPK20_RS20320	COG0765	amino acid transport
HPK20_RS20325	COG1126	abc transporter atp-binding protein
HPK20_RS20335	COG0724	RNA recognition motif
HPK20_RS20340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK20_RS20345	COG1522	sequence-specific DNA binding
HPK20_RS20350	COG2610	gluconate transmembrane transporter activity
HPK20_RS20355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPK20_RS20360	COG3622	Belongs to the hyi family
HPK20_RS20365	COG0235	Class ii aldolase
HPK20_RS20370	COG3395	kinase activity
HPK20_RS20375	COG2084	Dehydrogenase
HPK20_RS20380	COG1349	DNA-binding transcription factor activity
HPK20_RS20395	COG0583	DNA-binding transcription factor activity
HPK20_RS20400	COG2910	NAD(P)H-binding
HPK20_RS20415	COG1335	isochorismatase
HPK20_RS20420	COG2207	Transcriptional regulator
HPK20_RS20420	COG1609	Transcriptional regulator
HPK20_RS20435	COG2329	Antibiotic biosynthesis monooxygenase
HPK20_RS20440	COG3304	Inner membrane component domain
HPK20_RS20450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_RS20485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK20_RS20490	COG0419	ATPase involved in DNA repair
HPK20_RS20515	COG4581	dead DEAH box helicase
HPK20_RS20535	COG2176	DNA-directed DNA polymerase activity
HPK20_RS20555	COG0443	Heat shock 70 kDa protein
HPK20_RS20560	COG0095	Lipoate-protein ligase
HPK20_RS20575	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPK20_RS20580	COG1473	amidohydrolase
HPK20_RS20595	COG3722	fumarate hydratase activity
HPK20_RS20605	COG2213	PTS system mannitol-specific
HPK20_RS20605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_RS20610	COG0739	heme binding
HPK20_RS20625	COG0363	glucosamine-6-phosphate deaminase activity
HPK20_RS20650	COG0402	S-adenosylhomocysteine deaminase activity
HPK20_RS20655	COG2259	Doxx family
HPK20_RS20660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPK20_RS20665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPK20_RS20675	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK20_RS20680	COG1301	dicarboxylic acid transport
HPK20_RS20695	COG1917	Cupin 2, conserved barrel domain protein
HPK20_RS20695	COG2169	Transcriptional regulator
HPK20_RS20730	COG1764	response to oxidative stress
HPK20_RS20735	COG1846	Transcriptional regulator
HPK20_RS20740	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPK20_RS20760	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS20770	COG1902	pentaerythritol trinitrate reductase activity
HPK20_RS20775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK20_RS20785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK20_RS20820	COG0109	protoheme IX farnesyltransferase activity
HPK20_RS20835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPK20_RS20865	COG2169	Transcriptional regulator
HPK20_RS20885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_RS20890	COG0697	spore germination
HPK20_RS20895	COG0477	Major facilitator Superfamily
HPK20_RS20900	COG0625	glutathione transferase activity
HPK20_RS20910	COG1942	4-Oxalocrotonate Tautomerase
HPK20_RS20925	COG0583	DNA-binding transcription factor activity
HPK20_RS20945	COG3152	Membrane
HPK20_RS20965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPK20_RS20980	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPK20_RS20995	COG1620	l-lactate permease
HPK20_RS21000	COG0583	DNA-binding transcription factor activity
HPK20_RS21005	COG4172	Belongs to the ABC transporter superfamily
HPK20_RS21015	COG1067	ATP-dependent peptidase activity
HPK20_RS21020	COG0840	transmembrane signaling receptor activity
HPK20_RS21025	COG2211	Major facilitator Superfamily
HPK20_RS21030	COG0668	transmembrane transport
HPK20_RS21035	COG0569	domain protein
HPK20_RS21040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPK20_RS21050	COG3123	guanosine phosphorylase activity
HPK20_RS21055	COG1741	Belongs to the pirin family
HPK20_RS21065	COG5001	Diguanylate cyclase
HPK20_RS21090	COG3706	GGDEF domain
HPK20_RS21110	COG3706	GGDEF domain
HPK20_RS21135	COG2354	Protein conserved in bacteria
HPK20_RS21140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPK20_RS21145	COG0418	dihydroorotase activity
HPK20_RS21150	COG0633	Ferredoxin
HPK20_RS21150	COG3217	Mosc domain protein beta barrel domain protein
HPK20_RS21180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPK20_RS21185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_RS21195	COG0848	biopolymer transport protein
HPK20_RS21200	COG0811	peptide transport
HPK20_RS21205	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPK20_RS21210	COG3721	Heme iron utilization protein
HPK20_RS21215	COG0748	coenzyme F420 binding
HPK20_RS21225	COG0531	amino acid
HPK20_RS21230	COG1522	sequence-specific DNA binding
HPK20_RS21260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPK20_RS21265	COG2200	EAL domain
HPK20_RS21295	COG3300	MHYT domain
HPK20_RS21295	COG5001	Diguanylate cyclase
HPK20_RS21310	COG1765	OsmC-like protein
HPK20_RS21345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPK20_RS21375	COG0745	RESPONSE REGULATOR receiver
HPK20_RS21380	COG0642	Histidine kinase
HPK20_RS21390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPK20_RS21395	COG3186	Phenylalanine-4-hydroxylase
HPK20_RS21400	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPK20_RS21405	COG0534	Mate efflux family protein
HPK20_RS21415	COG0861	Integral membrane protein TerC family
HPK20_RS21425	COG0456	acetyltransferase
HPK20_RS21430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK20_RS21435	COG0662	Cupin 2, conserved barrel domain protein
HPK20_RS21440	COG0527	aspartate kinase activity
HPK20_RS21445	COG0561	phosphatase activity
HPK20_RS21455	COG0583	DNA-binding transcription factor activity
HPK20_RS21465	COG3437	response regulator, receiver
HPK20_RS21465	COG0784	Response regulator, receiver
HPK20_RS21475	COG0113	porphobilinogen synthase activity
HPK20_RS21485	COG0459	protein refolding
HPK20_RS21490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPK20_RS21515	COG2113	Glycine betaine
HPK20_RS21520	COG4176	ABC-type proline glycine betaine transport system permease component
HPK20_RS21525	COG4175	Glycine betaine
HPK20_RS21535	COG1166	arginine decarboxylase activity
HPK20_RS21545	COG1522	sequence-specific DNA binding
HPK20_RS21560	COG0765	amino acid transport
HPK20_RS21570	COG1686	Belongs to the peptidase S11 family
HPK20_RS21585	COG1566	PFAM secretion protein HlyD family protein
HPK20_RS21630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPK20_RS21640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPK20_RS21655	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS21675	COG0840	transmembrane signaling receptor activity
HPK20_RS21690	COG2985	domain, Protein
HPK20_RS21700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPK20_RS21720	COG1280	lysine exporter protein (LysE YggA)
HPK20_RS21765	COG3122	Protein conserved in bacteria
HPK20_RS21785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPK20_RS21785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPK20_RS21790	COG0509	glycine decarboxylation via glycine cleavage system
HPK20_RS21805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPK20_RS21815	COG3706	GGDEF domain
HPK20_RS21820	COG5001	Diguanylate cyclase
HPK20_RS21825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_RS21840	COG0546	phosphoglycolate phosphatase activity
HPK20_RS21860	COG0484	heat shock protein binding
HPK20_RS21870	COG5001	Diguanylate cyclase
HPK20_RS21870	COG1716	ATPase activity
HPK20_RS21875	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPK20_RS21885	COG4181	ATPase activity
HPK20_RS21890	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPK20_RS21900	COG1984	allophanate hydrolase subunit 2
HPK20_RS21910	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPK20_RS21915	COG5001	Diguanylate cyclase
HPK20_RS21915	COG5002	protein histidine kinase activity
HPK20_RS21915	COG3447	MASE1 domain protein
HPK20_RS21920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK20_RS21925	COG0840	transmembrane signaling receptor activity
HPK20_RS21930	COG0814	amino acid
HPK20_RS21935	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPK20_RS21940	COG0513	Belongs to the DEAD box helicase family
HPK20_RS21945	COG1309	transcriptional regulator
HPK20_RS21955	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPK20_RS21970	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPK20_RS22010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPK20_RS22020	COG0463	Glycosyl transferase, family 2
HPK20_RS22030	COG0583	DNA-binding transcription factor activity
HPK20_RS22035	COG0697	spore germination
HPK20_RS22040	COG2207	Transcriptional regulator
HPK20_RS22040	COG1917	Cupin 2, conserved barrel domain protein
HPK20_RS22065	COG0330	HflC and HflK could
HPK20_RS22075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPK20_RS22090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPK20_RS22095	COG0583	DNA-binding transcription factor activity
HPK20_RS22100	COG3781	membrane
HPK20_RS22110	COG1271	oxidase subunit
HPK20_RS22115	COG1294	oxidase, subunit
HPK20_RS22120	COG0800	Aldolase
HPK20_RS22125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_RS22130	COG1904	glucuronate isomerase
HPK20_RS22135	COG0246	Mannitol dehydrogenase
HPK20_RS22150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPK20_RS22160	COG2186	Transcriptional regulator
HPK20_RS22180	COG1070	Carbohydrate kinase
HPK20_RS22190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK20_RS22205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPK20_RS22235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPK20_RS22265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPK20_RS22275	COG2116	formate transmembrane transporter activity
HPK20_RS22280	COG1648	precorrin-2 dehydrogenase activity
HPK20_RS22280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPK20_RS22310	COG3118	belongs to the thioredoxin family
HPK20_RS22315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK20_RS22330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK20_RS22340	COG1596	polysaccharide export
HPK20_RS22365	COG0438	transferase activity, transferring glycosyl groups
HPK20_RS22370	COG0438	transferase activity, transferring glycosyl groups
HPK20_RS22370	COG0297	glycogen (starch) synthase activity
HPK20_RS22385	COG0247	lactate metabolic process
HPK20_RS22390	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPK20_RS22395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPK20_RS22400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPK20_RS22405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPK20_RS22460	COG4386	tail sheath protein
HPK20_RS22500	COG4695	Portal protein
HPK20_RS22545	COG0667	Aldo Keto reductase
HPK20_RS22550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_RS22560	COG0583	DNA-binding transcription factor activity
HPK20_RS22565	COG1335	isochorismatase
HPK20_RS22585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPK20_RS22585	COG1017	nitric oxide dioxygenase activity
HPK20_RS22590	COG0625	glutathione transferase activity