locus-tag	class	description
AL475_RS00005	COG3604	Transcriptional regulator
AL475_RS00015	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL475_RS00020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL475_RS00030	COG0366	Alpha amylase catalytic
AL475_RS00050	COG0714	Associated with various cellular activities
AL475_RS00085	COG3706	GGDEF domain
AL475_RS00095	COG0784	Response regulator, receiver
AL475_RS00095	COG2205	protein histidine kinase activity
AL475_RS00095	COG5002	protein histidine kinase activity
AL475_RS00110	COG3724	N-succinylarginine dihydrolase activity
AL475_RS00115	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS00140	COG4948	Mandelate Racemase Muconate Lactonizing
AL475_RS00165	COG0583	DNA-binding transcription factor activity
AL475_RS00190	COG3171	Protein conserved in bacteria
AL475_RS00195	COG0589	response to stress
AL475_RS00205	COG3530	Putative quorum-sensing-regulated virulence factor
AL475_RS00215	COG0579	oxidoreductase
AL475_RS00230	COG2204	response regulator
AL475_RS00240	COG1929	Belongs to the glycerate kinase type-1 family
AL475_RS00245	COG0383	alpha-mannosidase activity
AL475_RS00250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS00250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS00250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_RS00255	COG2188	Transcriptional regulator
AL475_RS00280	COG3300	MHYT domain
AL475_RS00280	COG5001	Diguanylate cyclase
AL475_RS00285	COG2271	Major facilitator Superfamily
AL475_RS00290	COG0584	glycerophosphoryl diester phosphodiesterase
AL475_RS00295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL475_RS00300	COG0583	DNA-binding transcription factor activity
AL475_RS00310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_RS00315	COG1879	ABC-type sugar transport system periplasmic component
AL475_RS00320	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL475_RS00325	COG1129	ABC transporter
AL475_RS00330	COG1869	D-ribose catabolic process
AL475_RS00350	COG3409	Peptidoglycan-binding domain 1 protein
AL475_RS00350	COG3501	Rhs element vgr protein
AL475_RS00375	COG3829	transcription factor binding
AL475_RS00445	COG1280	lysine exporter protein (LysE YggA)
AL475_RS00450	COG1846	Transcriptional regulator
AL475_RS00455	COG1230	cation diffusion facilitator family transporter
AL475_RS00465	COG0564	pseudouridine synthase activity
AL475_RS00470	COG1309	transcriptional regulator
AL475_RS00475	COG2130	NADP-dependent
AL475_RS00490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL475_RS00520	COG3842	ATPase activity
AL475_RS00530	COG2200	EAL domain
AL475_RS00535	COG0656	L-ascorbic acid biosynthetic process
AL475_RS00540	COG1902	pentaerythritol trinitrate reductase activity
AL475_RS00545	COG0583	DNA-binding transcription factor activity
AL475_RS00550	COG2814	Major facilitator Superfamily
AL475_RS00570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL475_RS00585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL475_RS00595	COG4702	Belongs to the UPF0303 family
AL475_RS00600	COG0673	inositol 2-dehydrogenase activity
AL475_RS00605	COG1349	DNA-binding transcription factor activity
AL475_RS00610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL475_RS00630	COG3240	lipase activity
AL475_RS00635	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS00640	COG0583	DNA-binding transcription factor activity
AL475_RS00650	COG1120	ATPase activity
AL475_RS00655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_RS00660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_RS00665	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL475_RS00670	COG4774	siderophore transport
AL475_RS00695	COG0840	transmembrane signaling receptor activity
AL475_RS00700	COG3384	dioxygenase
AL475_RS00705	COG0583	DNA-binding transcription factor activity
AL475_RS00715	COG1342	Belongs to the UPF0251 family
AL475_RS00720	COG0778	Nitroreductase
AL475_RS00725	COG0583	DNA-binding transcription factor activity
AL475_RS00735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_RS00740	COG0697	spore germination
AL475_RS00755	COG2814	Major facilitator Superfamily
AL475_RS00760	COG0583	DNA-binding transcription factor activity
AL475_RS00765	COG3300	MHYT domain
AL475_RS00765	COG5001	Diguanylate cyclase
AL475_RS00770	COG0739	heme binding
AL475_RS00785	COG0659	secondary active sulfate transmembrane transporter activity
AL475_RS00790	COG3314	Sporulation integral membrane protein YlbJ
AL475_RS00800	COG2199	diguanylate cyclase activity
AL475_RS00805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL475_RS00810	COG0581	inorganic phosphate transmembrane transporter activity
AL475_RS00815	COG0573	inorganic phosphate transmembrane transporter activity
AL475_RS00820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL475_RS00825	COG0840	transmembrane signaling receptor activity
AL475_RS00830	COG0513	Belongs to the DEAD box helicase family
AL475_RS00840	COG1388	LysM domain
AL475_RS00840	COG1376	ErfK ybiS ycfS ynhG family protein
AL475_RS00845	COG0415	Belongs to the DNA photolyase family
AL475_RS00855	COG3272	Protein of unknown function (DUF1722)
AL475_RS00860	COG0813	purine-nucleoside phosphorylase activity
AL475_RS00885	COG1566	PFAM secretion protein HlyD family protein
AL475_RS00920	COG0786	glutamate:sodium symporter activity
AL475_RS00935	COG1999	signal sequence binding
AL475_RS00945	COG1162	GTPase activity
AL475_RS00950	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL475_RS00965	COG4580	involved in the transport of maltose and maltodextrins
AL475_RS00980	COG1132	(ABC) transporter
AL475_RS00985	COG4974	Belongs to the 'phage' integrase family
AL475_RS00995	COG0326	Molecular chaperone. Has ATPase activity
AL475_RS01150	COG4695	Portal protein
AL475_RS01190	COG4386	tail sheath protein
AL475_RS01225	COG0671	phosphoesterase, PA-phosphatase related
AL475_RS01235	COG3383	formate dehydrogenase (NAD+) activity
AL475_RS01250	COG0840	transmembrane signaling receptor activity
AL475_RS01260	COG1131	(ABC) transporter
AL475_RS01265	COG2188	Transcriptional regulator
AL475_RS01275	COG3033	Beta-eliminating lyase
AL475_RS01280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL475_RS01285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL475_RS01295	COG0471	metal ion transport
AL475_RS01320	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AL475_RS01340	COG3501	Rhs element vgr protein
AL475_RS01350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL475_RS01355	COG1640	4-alpha-glucanotransferase
AL475_RS01360	COG0058	SHG alpha-glucan phosphorylase activity
AL475_RS01365	COG2909	trisaccharide binding
AL475_RS01380	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL475_RS01385	COG1845	cytochrome c oxidase, subunit III
AL475_RS01390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL475_RS01395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL475_RS01410	COG2084	Dehydrogenase
AL475_RS01425	COG0217	transcriptional regulatory protein
AL475_RS01460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL475_RS01465	COG1444	tRNA N-acetyltransferase activity
AL475_RS01490	COG0835	chemotaxis
AL475_RS01495	COG0840	transmembrane signaling receptor activity
AL475_RS01500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL475_RS01510	COG2201	protein-glutamate methylesterase activity
AL475_RS01525	COG0745	RESPONSE REGULATOR receiver
AL475_RS01565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL475_RS01600	COG0840	transmembrane signaling receptor activity
AL475_RS01620	COG0859	PFAM glycosyl transferase family 9
AL475_RS01625	COG0513	Belongs to the DEAD box helicase family
AL475_RS01635	COG0583	DNA-binding transcription factor activity
AL475_RS01640	COG2226	methyltransferase
AL475_RS01655	COG0724	RNA recognition motif
AL475_RS01660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL475_RS01665	COG1522	sequence-specific DNA binding
AL475_RS01670	COG2610	gluconate transmembrane transporter activity
AL475_RS01675	COG3622	Belongs to the hyi family
AL475_RS01680	COG0235	Class ii aldolase
AL475_RS01685	COG3395	kinase activity
AL475_RS01690	COG2084	Dehydrogenase
AL475_RS01695	COG1349	DNA-binding transcription factor activity
AL475_RS01710	COG0583	DNA-binding transcription factor activity
AL475_RS01715	COG2910	NAD(P)H-binding
AL475_RS01720	COG2076	Multidrug Resistance protein
AL475_RS01730	COG1335	isochorismatase
AL475_RS01735	COG2207	Transcriptional regulator
AL475_RS01735	COG1609	Transcriptional regulator
AL475_RS01750	COG2329	Antibiotic biosynthesis monooxygenase
AL475_RS01755	COG3304	Inner membrane component domain
AL475_RS01765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_RS01795	COG0583	DNA-binding transcription factor activity
AL475_RS01800	COG4221	oxidoreductase activity
AL475_RS01830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL475_RS01855	COG2176	DNA-directed DNA polymerase activity
AL475_RS01875	COG0443	Heat shock 70 kDa protein
AL475_RS01880	COG0095	Lipoate-protein ligase
AL475_RS01895	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL475_RS01900	COG1473	amidohydrolase
AL475_RS01915	COG3722	fumarate hydratase activity
AL475_RS01925	COG2213	PTS system mannitol-specific
AL475_RS01925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_RS01935	COG0739	heme binding
AL475_RS01950	COG0363	glucosamine-6-phosphate deaminase activity
AL475_RS01975	COG0402	S-adenosylhomocysteine deaminase activity
AL475_RS01980	COG2259	Doxx family
AL475_RS01985	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL475_RS01990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL475_RS02000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL475_RS02005	COG1301	dicarboxylic acid transport
AL475_RS02060	COG1764	response to oxidative stress
AL475_RS02065	COG1846	Transcriptional regulator
AL475_RS02070	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL475_RS02090	COG1280	lysine exporter protein (LysE YggA)
AL475_RS02100	COG1902	pentaerythritol trinitrate reductase activity
AL475_RS02105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL475_RS02115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL475_RS02150	COG0109	protoheme IX farnesyltransferase activity
AL475_RS02165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL475_RS02175	COG3447	MASE1 domain protein
AL475_RS02175	COG5002	protein histidine kinase activity
AL475_RS02175	COG5001	Diguanylate cyclase
AL475_RS02195	COG2169	Transcriptional regulator
AL475_RS02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_RS02220	COG0697	spore germination
AL475_RS02225	COG0477	Major facilitator Superfamily
AL475_RS02230	COG0625	glutathione transferase activity
AL475_RS02235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL475_RS02245	COG1942	4-Oxalocrotonate Tautomerase
AL475_RS02260	COG0583	DNA-binding transcription factor activity
AL475_RS02285	COG3152	Membrane
AL475_RS02305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL475_RS02320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL475_RS02335	COG1620	l-lactate permease
AL475_RS02345	COG0583	DNA-binding transcription factor activity
AL475_RS02350	COG4172	Belongs to the ABC transporter superfamily
AL475_RS02360	COG1067	ATP-dependent peptidase activity
AL475_RS02365	COG0840	transmembrane signaling receptor activity
AL475_RS02370	COG2211	Major facilitator Superfamily
AL475_RS02375	COG0668	transmembrane transport
AL475_RS02380	COG0569	domain protein
AL475_RS02385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_RS02400	COG3123	guanosine phosphorylase activity
AL475_RS02410	COG2814	Major facilitator Superfamily
AL475_RS02525	COG0745	RESPONSE REGULATOR receiver
AL475_RS02530	COG1741	Belongs to the pirin family
AL475_RS02565	COG3706	GGDEF domain
AL475_RS02585	COG3706	GGDEF domain
AL475_RS02595	COG1846	Transcriptional regulator
AL475_RS02600	COG2315	Protein conserved in bacteria
AL475_RS02605	COG0835	chemotaxis
AL475_RS02605	COG0784	Response regulator, receiver
AL475_RS02610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL475_RS02635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL475_RS02655	COG1522	sequence-specific DNA binding
AL475_RS02665	COG0393	Putative heavy-metal-binding
AL475_RS02670	COG0823	Involved in the tonB-independent uptake of proteins
AL475_RS02675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL475_RS02680	COG0534	Mate efflux family protein
AL475_RS02690	COG1653	transport
AL475_RS02695	COG3842	ATPase activity
AL475_RS02700	COG0395	ABC-type sugar transport system, permease component
AL475_RS02705	COG1175	transmembrane transport
AL475_RS02720	COG0840	transmembrane signaling receptor activity
AL475_RS02730	COG0800	Aldolase
AL475_RS02735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_RS02750	COG1917	Cupin 2, conserved barrel domain protein
AL475_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS02765	COG1414	Transcriptional regulator
AL475_RS02770	COG0517	IMP dehydrogenase activity
AL475_RS02790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL475_RS02800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_RS02840	COG3842	ATPase activity
AL475_RS02850	COG1175	transmembrane transport
AL475_RS02855	COG3833	ABC-type maltose transport systems, permease component
AL475_RS02880	COG1349	DNA-binding transcription factor activity
AL475_RS02900	COG2354	Protein conserved in bacteria
AL475_RS02905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL475_RS02910	COG0418	dihydroorotase activity
AL475_RS02920	COG3217	Mosc domain protein beta barrel domain protein
AL475_RS02920	COG0633	Ferredoxin
AL475_RS02950	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL475_RS02955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_RS02965	COG0848	biopolymer transport protein
AL475_RS02970	COG0811	peptide transport
AL475_RS02975	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL475_RS02980	COG3721	Heme iron utilization protein
AL475_RS02985	COG0748	coenzyme F420 binding
AL475_RS02995	COG0531	amino acid
AL475_RS03000	COG1522	sequence-specific DNA binding
AL475_RS03025	COG1151	hydroxylamine reductase activity
AL475_RS03030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL475_RS03035	COG2200	EAL domain
AL475_RS03065	COG5001	Diguanylate cyclase
AL475_RS03065	COG3300	MHYT domain
AL475_RS03080	COG1765	OsmC-like protein
AL475_RS03115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL475_RS03150	COG0642	Histidine kinase
AL475_RS03160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL475_RS03165	COG3186	Phenylalanine-4-hydroxylase
AL475_RS03170	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL475_RS03175	COG0534	Mate efflux family protein
AL475_RS03185	COG0861	Integral membrane protein TerC family
AL475_RS03195	COG0456	acetyltransferase
AL475_RS03200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL475_RS03205	COG0662	Cupin 2, conserved barrel domain protein
AL475_RS03210	COG0527	aspartate kinase activity
AL475_RS03215	COG0561	phosphatase activity
AL475_RS03225	COG0583	DNA-binding transcription factor activity
AL475_RS03235	COG0784	Response regulator, receiver
AL475_RS03235	COG3437	response regulator, receiver
AL475_RS03245	COG0113	porphobilinogen synthase activity
AL475_RS03255	COG0459	protein refolding
AL475_RS03260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL475_RS03265	COG2239	Acts as a magnesium transporter
AL475_RS03285	COG2113	Glycine betaine
AL475_RS03290	COG4176	ABC-type proline glycine betaine transport system permease component
AL475_RS03295	COG4175	Glycine betaine
AL475_RS03305	COG1166	arginine decarboxylase activity
AL475_RS03315	COG1522	sequence-specific DNA binding
AL475_RS03330	COG0765	amino acid transport
AL475_RS03340	COG1686	Belongs to the peptidase S11 family
AL475_RS03355	COG1566	PFAM secretion protein HlyD family protein
AL475_RS03365	COG3338	carbonate dehydratase activity
AL475_RS03400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL475_RS03410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL475_RS03420	COG1280	lysine exporter protein (LysE YggA)
AL475_RS03425	COG0513	Belongs to the DEAD box helicase family
AL475_RS03440	COG0840	transmembrane signaling receptor activity
AL475_RS03455	COG2985	domain, Protein
AL475_RS03465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL475_RS03485	COG1280	lysine exporter protein (LysE YggA)
AL475_RS03530	COG3122	Protein conserved in bacteria
AL475_RS03550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL475_RS03550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL475_RS03555	COG0509	glycine decarboxylation via glycine cleavage system
AL475_RS03570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL475_RS03580	COG3706	GGDEF domain
AL475_RS03585	COG5001	Diguanylate cyclase
AL475_RS03590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_RS03605	COG0546	phosphoglycolate phosphatase activity
AL475_RS03630	COG0484	heat shock protein binding
AL475_RS03640	COG1716	ATPase activity
AL475_RS03640	COG5001	Diguanylate cyclase
AL475_RS03645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL475_RS03655	COG4181	ATPase activity
AL475_RS03660	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL475_RS03670	COG1984	allophanate hydrolase subunit 2
AL475_RS03680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL475_RS03685	COG3447	MASE1 domain protein
AL475_RS03685	COG5002	protein histidine kinase activity
AL475_RS03685	COG5001	Diguanylate cyclase
AL475_RS03690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL475_RS03695	COG0840	transmembrane signaling receptor activity
AL475_RS03700	COG0814	amino acid
AL475_RS03705	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL475_RS03710	COG0513	Belongs to the DEAD box helicase family
AL475_RS03715	COG1309	transcriptional regulator
AL475_RS03725	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL475_RS03740	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL475_RS03770	COG0840	transmembrane signaling receptor activity
AL475_RS03780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL475_RS03790	COG0463	Glycosyl transferase, family 2
AL475_RS03800	COG0583	DNA-binding transcription factor activity
AL475_RS03805	COG0697	spore germination
AL475_RS03810	COG2207	Transcriptional regulator
AL475_RS03810	COG1917	Cupin 2, conserved barrel domain protein
AL475_RS03835	COG0330	HflC and HflK could
AL475_RS03845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL475_RS03860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL475_RS03865	COG0583	DNA-binding transcription factor activity
AL475_RS03870	COG3781	membrane
AL475_RS03875	COG0243	molybdopterin cofactor binding
AL475_RS03880	COG1271	oxidase subunit
AL475_RS03885	COG1294	oxidase, subunit
AL475_RS03890	COG0800	Aldolase
AL475_RS03895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_RS03900	COG1904	glucuronate isomerase
AL475_RS03905	COG0246	Mannitol dehydrogenase
AL475_RS03920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL475_RS03930	COG2186	Transcriptional regulator
AL475_RS03940	COG2390	Transcriptional regulator
AL475_RS03950	COG1070	Carbohydrate kinase
AL475_RS03960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL475_RS03975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL475_RS03985	COG1120	ATPase activity
AL475_RS03990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL475_RS04025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL475_RS04050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL475_RS04095	COG3118	belongs to the thioredoxin family
AL475_RS04100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL475_RS04115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL475_RS04125	COG1596	polysaccharide export
AL475_RS04150	COG0438	transferase activity, transferring glycosyl groups
AL475_RS04155	COG0438	transferase activity, transferring glycosyl groups
AL475_RS04155	COG0297	glycogen (starch) synthase activity
AL475_RS04170	COG0247	lactate metabolic process
AL475_RS04175	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AL475_RS04180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL475_RS04185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL475_RS04190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL475_RS04240	COG4386	tail sheath protein
AL475_RS04280	COG4695	Portal protein
AL475_RS04340	COG0110	maltose O-acetyltransferase activity
AL475_RS04450	COG3081	Nucleoid-associated protein
AL475_RS04475	COG4974	Belongs to the 'phage' integrase family
AL475_RS04490	COG3132	Protein of unknown function, DUF480
AL475_RS04495	COG2827	Endonuclease containing a URI domain
AL475_RS04505	COG1879	ABC-type sugar transport system periplasmic component
AL475_RS04510	COG5002	protein histidine kinase activity
AL475_RS04510	COG0784	Response regulator, receiver
AL475_RS04530	COG1492	cobalamin metabolic process
AL475_RS04535	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL475_RS04540	COG4149	molybdate abc transporter
AL475_RS04545	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL475_RS04560	COG1289	transmembrane transporter activity
AL475_RS04600	COG0210	DNA helicase
AL475_RS04605	COG1335	isochorismatase
AL475_RS04610	COG1803	Methylglyoxal synthase
AL475_RS04615	COG1879	ABC-type sugar transport system periplasmic component
AL475_RS04620	COG0784	Response regulator, receiver
AL475_RS04620	COG2198	Histidine kinase
AL475_RS04620	COG2205	protein histidine kinase activity
AL475_RS04625	COG0469	pyruvate kinase activity
AL475_RS04630	COG2271	Major facilitator Superfamily
AL475_RS04655	COG1979	alcohol dehydrogenase
AL475_RS04660	COG2207	Transcriptional regulator
AL475_RS04675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL475_RS04700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL475_RS04705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL475_RS04715	COG0183	Belongs to the thiolase family
AL475_RS04755	COG0243	molybdopterin cofactor binding
AL475_RS04770	COG3850	Histidine kinase
AL475_RS04775	COG2197	response regulator
AL475_RS04780	COG3069	C4-dicarboxylate transmembrane transporter activity
AL475_RS04795	COG2814	Major facilitator Superfamily
AL475_RS04800	COG0840	transmembrane signaling receptor activity
AL475_RS04805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL475_RS04825	COG0840	transmembrane signaling receptor activity
AL475_RS04830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL475_RS04845	COG2897	thiosulfate sulfurtransferase activity
AL475_RS04850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL475_RS04860	COG0302	gtp cyclohydrolase
AL475_RS04865	COG0531	amino acid
AL475_RS04875	COG4303	Ethanolamine ammonia lyase large subunit
AL475_RS04885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL475_RS04885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL475_RS04890	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL475_RS04895	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL475_RS04905	COG1011	Hydrolase
AL475_RS04910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL475_RS04925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL475_RS04930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL475_RS04940	COG3842	ATPase activity
AL475_RS04960	COG2866	Carboxypeptidase
AL475_RS04985	COG4166	transmembrane transport
AL475_RS04990	COG4174	ABC transporter (Permease)
AL475_RS04995	COG4239	(ABC) transporter, permease
AL475_RS05000	COG4172	Belongs to the ABC transporter superfamily
AL475_RS05005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL475_RS05025	COG4251	negative regulation of phosphorylation
AL475_RS05025	COG2203	Gaf domain
AL475_RS05025	COG5001	Diguanylate cyclase
AL475_RS05025	COG3706	GGDEF domain
AL475_RS05035	COG3706	GGDEF domain
AL475_RS05045	COG2501	S4 domain
AL475_RS05085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL475_RS05110	COG2207	Transcriptional regulator
AL475_RS05130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL475_RS05140	COG0488	(ABC) transporter
AL475_RS05150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL475_RS05160	COG2814	Major facilitator Superfamily
AL475_RS05180	COG3710	Transcriptional regulator
AL475_RS05195	COG0384	phenazine biosynthesis protein PhzF
AL475_RS05220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_RS05235	COG2233	PERMEase
AL475_RS05255	COG1953	Uracil, thiamine, allantoin
AL475_RS05265	COG0765	amino acid transport
AL475_RS05270	COG0765	amino acid transport
AL475_RS05300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL475_RS05320	COG0402	S-adenosylhomocysteine deaminase activity
AL475_RS05355	COG1079	Belongs to the binding-protein-dependent transport system permease family
AL475_RS05360	COG4603	Belongs to the binding-protein-dependent transport system permease family
AL475_RS05365	COG3845	ABC transporter
AL475_RS05370	COG1309	transcriptional regulator
AL475_RS05405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL475_RS05410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL475_RS05420	COG0745	RESPONSE REGULATOR receiver
AL475_RS05435	COG3140	Belongs to the UPF0181 family
AL475_RS05440	COG0023	Translation Initiation Factor
AL475_RS05465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL475_RS05465	COG1042	CoA-binding domain protein
AL475_RS05465	COG0045	succinate-CoA ligase (ADP-forming) activity
AL475_RS05470	COG0583	DNA-binding transcription factor activity
AL475_RS05475	COG4771	TonB-dependent receptor
AL475_RS05475	COG1629	transport
AL475_RS05495	COG2050	protein possibly involved in aromatic compounds catabolism
AL475_RS05500	COG0501	Belongs to the peptidase M48B family
AL475_RS05505	COG2824	Alkylphosphonate utilization operon protein PhnA
AL475_RS05515	COG0861	Integral membrane protein TerC family
AL475_RS05520	COG0737	Belongs to the 5'-nucleotidase family
AL475_RS05525	COG3593	DNA synthesis involved in DNA repair
AL475_RS05535	COG0583	DNA-binding transcription factor activity
AL475_RS05540	COG2116	formate transmembrane transporter activity
AL475_RS05545	COG2353	YceI-like domain
AL475_RS05550	COG3038	cytochrome b561
AL475_RS05575	COG5001	Diguanylate cyclase
AL475_RS05585	COG0243	molybdopterin cofactor binding
AL475_RS05590	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL475_RS05595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL475_RS05595	COG1017	nitric oxide dioxygenase activity
AL475_RS05610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL475_RS05625	COG2181	nitrate reductase activity
AL475_RS05625	COG0247	lactate metabolic process
AL475_RS05630	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL475_RS05630	COG1902	pentaerythritol trinitrate reductase activity
AL475_RS05650	COG1760	l-serine dehydratase
AL475_RS05680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL475_RS05690	COG0784	Response regulator, receiver
AL475_RS05690	COG2205	protein histidine kinase activity
AL475_RS05690	COG5002	protein histidine kinase activity
AL475_RS05695	COG3437	response regulator, receiver
AL475_RS05705	COG2207	Transcriptional regulator
AL475_RS05710	COG0582	viral genome integration into host DNA
AL475_RS05720	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL475_RS05725	COG2202	Pas domain
AL475_RS05725	COG2200	EAL domain
AL475_RS05725	COG2199	diguanylate cyclase activity
AL475_RS05745	COG4251	negative regulation of phosphorylation
AL475_RS05745	COG2203	Gaf domain
AL475_RS05745	COG5001	Diguanylate cyclase
AL475_RS05745	COG3706	GGDEF domain
AL475_RS05795	COG2181	nitrate reductase activity
AL475_RS05800	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AL475_RS05805	COG1140	nitrate reductase beta subunit
AL475_RS05810	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL475_RS05815	COG2223	nitrite transmembrane transporter activity
AL475_RS05820	COG3850	Histidine kinase
AL475_RS05825	COG2197	response regulator
AL475_RS05830	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AL475_RS05835	COG2239	Acts as a magnesium transporter
AL475_RS05840	COG3290	protein histidine kinase activity
AL475_RS05840	COG0840	transmembrane signaling receptor activity
AL475_RS05890	COG1518	maintenance of DNA repeat elements
AL475_RS05905	COG2003	Belongs to the UPF0758 family
AL475_RS05940	COG0328	RNA-DNA hybrid ribonuclease activity
AL475_RS05980	COG3501	Rhs element vgr protein
AL475_RS06000	COG0523	cobalamin synthesis protein
AL475_RS06015	COG0156	8-amino-7-oxononanoate synthase activity
AL475_RS06020	COG2205	protein histidine kinase activity
AL475_RS06020	COG0784	Response regulator, receiver
AL475_RS06025	COG0419	ATPase involved in DNA repair
AL475_RS06035	COG1609	Transcriptional regulator
AL475_RS06040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_RS06040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_RS06045	COG1105	Belongs to the carbohydrate kinase PfkB family
AL475_RS06050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS06050	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL475_RS06050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS06055	COG4067	protein conserved in archaea
AL475_RS06055	COG0189	ligase activity
AL475_RS06065	COG0602	queuosine metabolic process
AL475_RS06070	COG1328	CTP reductase activity
AL475_RS06125	COG2207	Transcriptional regulator
AL475_RS06135	COG1073	alpha beta
AL475_RS06140	COG1073	alpha beta
AL475_RS06150	COG1902	pentaerythritol trinitrate reductase activity
AL475_RS06155	COG4221	oxidoreductase activity
AL475_RS06170	COG1073	alpha beta
AL475_RS06195	COG1566	PFAM secretion protein HlyD family protein
AL475_RS06200	COG1309	transcriptional regulator
AL475_RS06220	COG1280	lysine exporter protein (LysE YggA)
AL475_RS06225	COG0745	RESPONSE REGULATOR receiver
AL475_RS06235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL475_RS06245	COG0583	DNA-binding transcription factor activity
AL475_RS06260	COG1309	transcriptional regulator
AL475_RS06265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL475_RS06295	COG1335	isochorismatase
AL475_RS06300	COG4977	sequence-specific DNA binding
AL475_RS06305	COG0456	acetyltransferase
AL475_RS06315	COG1280	lysine exporter protein (LysE YggA)
AL475_RS06320	COG0494	nUDIX hydrolase
AL475_RS06330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL475_RS06360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL475_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS06390	COG0454	-acetyltransferase
AL475_RS06450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL475_RS06455	COG0789	Transcriptional regulator
AL475_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS06520	COG4628	conserved protein (DUF2132)
AL475_RS06535	COG0672	)-iron permease
AL475_RS06555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL475_RS06560	COG0513	Belongs to the DEAD box helicase family
AL475_RS06575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL475_RS06585	COG0583	DNA-binding transcription factor activity
AL475_RS06590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL475_RS06600	COG3710	Transcriptional regulator
AL475_RS06605	COG4232	protein-disulfide reductase activity
AL475_RS06610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL475_RS06615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL475_RS06625	COG1252	NADH dehydrogenase
AL475_RS06635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS06640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS06650	COG2207	Transcriptional regulator
AL475_RS06655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS06655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS06655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_RS06665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_RS06700	COG1538	Outer membrane efflux protein
AL475_RS06710	COG1132	(ABC) transporter
AL475_RS06725	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL475_RS06730	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AL475_RS06735	COG1349	DNA-binding transcription factor activity
AL475_RS06740	COG0110	maltose O-acetyltransferase activity
AL475_RS06745	COG3706	GGDEF domain
AL475_RS06755	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL475_RS06760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL475_RS06770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_RS06780	COG0747	negative chemotaxis
AL475_RS06785	COG4172	Belongs to the ABC transporter superfamily
AL475_RS06795	COG3437	response regulator, receiver
AL475_RS06800	COG2198	Histidine kinase
AL475_RS06800	COG2205	protein histidine kinase activity
AL475_RS06800	COG0784	Response regulator, receiver
AL475_RS06810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL475_RS06835	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_RS06850	COG2423	ornithine cyclodeaminase activity
AL475_RS06860	COG4145	pantothenate transmembrane transporter activity
AL475_RS06865	COG0583	DNA-binding transcription factor activity
AL475_RS06870	COG0435	Glutathione S-transferase
AL475_RS06875	COG0400	carboxylic ester hydrolase activity
AL475_RS06880	COG1280	lysine exporter protein (LysE YggA)
AL475_RS06895	COG1473	amidohydrolase
AL475_RS06915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_RS06920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL475_RS06925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL475_RS06935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL475_RS06950	COG2721	sulfolactate sulfo-lyase activity
AL475_RS07005	COG0625	glutathione transferase activity
AL475_RS07015	COG1472	Belongs to the glycosyl hydrolase 3 family
AL475_RS07025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL475_RS07035	COG0573	inorganic phosphate transmembrane transporter activity
AL475_RS07040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL475_RS07050	COG2207	Transcriptional regulator
AL475_RS07060	COG1464	Belongs to the NlpA lipoprotein family
AL475_RS07065	COG0512	Glutamine amidotransferase of anthranilate synthase
AL475_RS07065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL475_RS07085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_RS07100	COG0653	protein targeting
AL475_RS07105	COG2814	Major facilitator Superfamily
AL475_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS07135	COG1024	Enoyl-CoA hydratase
AL475_RS07140	COG1024	Enoyl-CoA hydratase
AL475_RS07145	COG1960	acyl-CoA dehydrogenase activity
AL475_RS07155	COG0183	Belongs to the thiolase family
AL475_RS07165	COG1960	acyl-CoA dehydrogenase activity
AL475_RS07170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL475_RS07175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL475_RS07190	COG0450	alkyl hydroperoxide reductase
AL475_RS07195	COG3634	alkyl hydroperoxide reductase activity
AL475_RS07225	COG2207	Transcriptional regulator
AL475_RS07225	COG1609	Transcriptional regulator
AL475_RS07230	COG1454	alcohol dehydrogenase
AL475_RS07235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL475_RS07305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL475_RS07320	COG2207	Transcriptional regulator
AL475_RS07320	COG1609	Transcriptional regulator
AL475_RS07325	COG4604	ABC transporter, ATP-binding protein
AL475_RS07330	COG4605	iron ion homeostasis
AL475_RS07335	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_RS07360	COG5380	lipid catabolic process
AL475_RS07365	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL475_RS07375	COG1522	sequence-specific DNA binding
AL475_RS07395	COG2814	Major facilitator Superfamily
AL475_RS07405	COG0840	transmembrane signaling receptor activity
AL475_RS07420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL475_RS07425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL475_RS07430	COG3279	Response regulator of the LytR AlgR family
AL475_RS07435	COG3275	phosphorelay sensor kinase activity
AL475_RS07440	COG4989	oxidoreductase activity
AL475_RS07455	COG0366	Alpha amylase catalytic
AL475_RS07460	COG3227	Zinc metalloprotease (Elastase)
AL475_RS07465	COG3047	cAMP biosynthetic process
AL475_RS07470	COG0071	Belongs to the small heat shock protein (HSP20) family
AL475_RS07480	COG0251	oxidation-reduction process
AL475_RS07500	COG1132	(ABC) transporter
AL475_RS07505	COG1132	(ABC) transporter
AL475_RS07515	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL475_RS07520	COG2246	polysaccharide biosynthetic process
AL475_RS07530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL475_RS07540	COG0242	peptide deformylase activity
AL475_RS07550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_RS07555	COG2084	Dehydrogenase
AL475_RS07565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL475_RS07570	COG0583	DNA-binding transcription factor activity
AL475_RS07615	COG1063	alcohol dehydrogenase
AL475_RS07620	COG0156	8-amino-7-oxononanoate synthase activity
AL475_RS07625	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS07630	COG3284	Transcriptional regulator
AL475_RS07640	COG0346	lactoylglutathione lyase activity
AL475_RS07660	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL475_RS07670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL475_RS07675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL475_RS07680	COG0363	glucosamine-6-phosphate deaminase activity
AL475_RS07685	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL475_RS07700	COG0583	DNA-binding transcription factor activity
AL475_RS07715	COG1410	methionine synthase
AL475_RS07715	COG0646	methionine synthase
AL475_RS07720	COG0531	amino acid
AL475_RS07735	COG1473	amidohydrolase
AL475_RS07740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL475_RS07745	COG1929	Belongs to the glycerate kinase type-1 family
AL475_RS07750	COG2610	gluconate transmembrane transporter activity
AL475_RS07755	COG3835	regulator
AL475_RS07760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL475_RS07765	COG4533	DNA binding
AL475_RS07780	COG0840	transmembrane signaling receptor activity
AL475_RS07805	COG0251	oxidation-reduction process
AL475_RS07840	COG4964	Belongs to the GSP D family
AL475_RS07880	COG0798	PFAM Bile acid sodium symporter
AL475_RS07905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL475_RS07910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL475_RS07910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL475_RS07920	COG0745	RESPONSE REGULATOR receiver
AL475_RS07940	COG3036	rescue of stalled ribosome
AL475_RS07945	COG1278	Cold shock
AL475_RS07950	COG4681	YaeQ
AL475_RS07960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL475_RS07960	COG1017	nitric oxide dioxygenase activity
AL475_RS07965	COG0243	molybdopterin cofactor binding
AL475_RS07970	COG0437	4 iron, 4 sulfur cluster binding
AL475_RS07985	COG0004	ammonium transporteR
AL475_RS07990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL475_RS07995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL475_RS08005	COG1177	transmembrane transport
AL475_RS08015	COG3842	ATPase activity
AL475_RS08040	COG0589	response to stress
AL475_RS08045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL475_RS08060	COG2217	Heavy metal translocating P-type atpase
AL475_RS08070	COG2010	Cytochrome c
AL475_RS08085	COG3278	Belongs to the heme-copper respiratory oxidase family
AL475_RS08100	COG0784	Response regulator, receiver
AL475_RS08100	COG2205	protein histidine kinase activity
AL475_RS08185	COG3120	sequence-specific DNA binding
AL475_RS08190	COG1067	ATP-dependent peptidase activity
AL475_RS08195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL475_RS08210	COG0488	(ABC) transporter
AL475_RS08220	COG0116	Belongs to the methyltransferase superfamily
AL475_RS08220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL475_RS08230	COG0167	dihydroorotate dehydrogenase activity
AL475_RS08245	COG0308	aminopeptidase N
AL475_RS08265	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL475_RS08270	COG1956	GAF domain-containing protein
AL475_RS08275	COG1132	(ABC) transporter
AL475_RS08280	COG2995	paraquat-inducible protein a
AL475_RS08285	COG3008	intermembrane lipid transfer
AL475_RS08295	COG2996	Protein conserved in bacteria
AL475_RS08310	COG0574	Belongs to the PEP-utilizing enzyme family
AL475_RS08310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL475_RS08315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL475_RS08320	COG1666	GTP binding
AL475_RS08335	COG1115	amino acid carrier protein
AL475_RS08360	COG3501	Rhs element vgr protein
AL475_RS08370	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL475_RS08380	COG1643	Atp-dependent helicase
AL475_RS08385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL475_RS08395	COG3005	denitrification pathway
AL475_RS08420	COG3706	GGDEF domain
AL475_RS08435	COG0443	Heat shock 70 kDa protein
AL475_RS08440	COG3706	GGDEF domain
AL475_RS08450	COG3706	GGDEF domain
AL475_RS08465	COG2999	glutathione oxidoreductase activity
AL475_RS08495	COG0243	molybdopterin cofactor binding
AL475_RS08500	COG3005	denitrification pathway
AL475_RS08510	COG0602	queuosine metabolic process
AL475_RS08515	COG0561	phosphatase activity
AL475_RS08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_RS08530	COG4597	amino acid ABC transporter
AL475_RS08535	COG0765	amino acid transport
AL475_RS08540	COG1126	abc transporter atp-binding protein
AL475_RS08545	COG0670	Belongs to the BI1 family
AL475_RS08550	COG2920	part of a sulfur-relay system
AL475_RS08555	COG1254	Belongs to the acylphosphatase family
AL475_RS08560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL475_RS08565	COG3391	amine dehydrogenase activity
AL475_RS08575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL475_RS08585	COG2010	Cytochrome c
AL475_RS08610	COG5002	protein histidine kinase activity
AL475_RS08615	COG0745	RESPONSE REGULATOR receiver
AL475_RS08630	COG0668	transmembrane transport
AL475_RS08665	COG1278	Cold shock
AL475_RS08725	COG0835	chemotaxis
AL475_RS08725	COG0784	Response regulator, receiver
AL475_RS08735	COG4565	transcriptional regulatory protein
AL475_RS08740	COG3290	protein histidine kinase activity
AL475_RS08755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_RS08775	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL475_RS08780	COG3063	Type IV pilus biogenesis stability protein PilW
AL475_RS08795	COG1451	nucleotide metabolic process
AL475_RS08805	COG0583	DNA-binding transcription factor activity
AL475_RS08855	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL475_RS08860	COG4139	cobalamin transport
AL475_RS08865	COG2988	succinylglutamate desuccinylase activity
AL475_RS08880	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL475_RS08885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL475_RS08890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL475_RS08895	COG0702	epimerase
AL475_RS08900	COG1823	symporter activity
AL475_RS08910	COG2925	Exonuclease
AL475_RS08915	COG1380	Effector of murein hydrolase LrgA
AL475_RS08920	COG1346	cytolysis
AL475_RS08925	COG0295	cytidine deaminase activity
AL475_RS08930	COG3300	MHYT domain
AL475_RS08930	COG5001	Diguanylate cyclase
AL475_RS08960	COG0500	methyltransferase
AL475_RS08970	COG0776	regulation of translation
AL475_RS08975	COG0072	phenylalanine-tRNA ligase activity
AL475_RS08975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL475_RS08980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL475_RS09000	COG2133	pyrroloquinoline quinone binding
AL475_RS09035	COG0322	excinuclease ABC activity
AL475_RS09040	COG2197	response regulator
AL475_RS09045	COG0417	DNA replication proofreading
AL475_RS09050	COG5001	Diguanylate cyclase
AL475_RS09060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL475_RS09065	COG3099	Belongs to the UPF0263 family
AL475_RS09080	COG1228	amidohydrolase
AL475_RS09085	COG0010	Belongs to the arginase family
AL475_RS09095	COG2986	histidine ammonia-lyase
AL475_RS09115	COG0247	lactate metabolic process
AL475_RS09115	COG0277	FAD linked oxidase domain protein
AL475_RS09130	COG2885	chlorophyll binding
AL475_RS09150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL475_RS09155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL475_RS09160	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS09165	COG2957	Belongs to the agmatine deiminase family
AL475_RS09175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL475_RS09180	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS09185	COG1396	sequence-specific DNA binding
AL475_RS09185	COG1917	Cupin 2, conserved barrel domain protein
AL475_RS09190	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL475_RS09195	COG0174	glutamine synthetase
AL475_RS09200	COG1757	Na H antiporter
AL475_RS09215	COG0583	DNA-binding transcription factor activity
AL475_RS09230	COG1643	Atp-dependent helicase
AL475_RS09235	COG0281	malic enzyme
AL475_RS09270	COG0583	DNA-binding transcription factor activity
AL475_RS09285	COG0640	Transcriptional regulator
AL475_RS09310	COG2949	membrane
AL475_RS09320	COG1414	Transcriptional regulator
AL475_RS09325	COG1414	Transcriptional regulator
AL475_RS09335	COG1454	alcohol dehydrogenase
AL475_RS09340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL475_RS09360	COG0492	ferredoxin-NADP+ reductase activity
AL475_RS09365	COG4988	ABC transporter
AL475_RS09370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL475_RS09385	COG1187	pseudouridine synthase activity
AL475_RS09390	COG0009	L-threonylcarbamoyladenylate synthase
AL475_RS09395	COG0613	PHP domain protein
AL475_RS09405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL475_RS09410	COG0512	Glutamine amidotransferase of anthranilate synthase
AL475_RS09415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL475_RS09420	COG0135	phosphoribosylanthranilate isomerase activity
AL475_RS09420	COG0134	indole-3-glycerol-phosphate synthase activity
AL475_RS09425	COG0133	tryptophan synthase activity
AL475_RS09430	COG0159	tryptophan synthase activity
AL475_RS09435	COG1301	dicarboxylic acid transport
AL475_RS09455	COG2350	Protein conserved in bacteria
AL475_RS09465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL475_RS09470	COG0583	DNA-binding transcription factor activity
AL475_RS09485	COG0612	Peptidase, M16
AL475_RS09505	COG0625	glutathione transferase activity
AL475_RS09515	COG2771	luxR family
AL475_RS09515	COG2200	EAL domain
AL475_RS09520	COG0840	transmembrane signaling receptor activity
AL475_RS09535	COG1794	racemase activity, acting on amino acids and derivatives
AL475_RS09540	COG0346	lactoylglutathione lyase activity
AL475_RS09545	COG5002	protein histidine kinase activity
AL475_RS09550	COG0745	RESPONSE REGULATOR receiver
AL475_RS09570	COG0488	(ABC) transporter
AL475_RS09575	COG1032	radical SAM domain protein
AL475_RS09580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL475_RS09590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_RS09590	COG4191	Histidine kinase
AL475_RS09605	COG3070	regulator of competence-specific genes
AL475_RS09615	COG2431	L-lysine efflux transmembrane transporter activity
AL475_RS09625	COG0076	glutamate decarboxylase activity
AL475_RS09630	COG1737	Transcriptional regulator
AL475_RS09635	COG1454	alcohol dehydrogenase
AL475_RS09635	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS09640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL475_RS09650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL475_RS09655	COG1960	acyl-CoA dehydrogenase activity
AL475_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS09690	COG0784	Response regulator, receiver
AL475_RS09690	COG5002	protein histidine kinase activity
AL475_RS09700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL475_RS09705	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL475_RS09710	COG2885	chlorophyll binding
AL475_RS09715	COG0823	Involved in the tonB-independent uptake of proteins
AL475_RS09730	COG0811	peptide transport
AL475_RS09735	COG0824	Thioesterase
AL475_RS09745	COG4890	Cyd operon protein YbgT
AL475_RS09750	COG1294	oxidase, subunit
AL475_RS09755	COG1271	oxidase subunit
AL475_RS09760	COG2255	four-way junction helicase activity
AL475_RS09765	COG0632	four-way junction helicase activity
AL475_RS09770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL475_RS09775	COG0215	cysteine-tRNA ligase activity
AL475_RS09780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL475_RS09785	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL475_RS09790	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL475_RS09795	COG3012	SEC-C Motif Domain Protein
AL475_RS09800	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL475_RS09805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL475_RS09810	COG1199	ATP-dependent helicase activity
AL475_RS09815	COG3923	Primosomal replication protein n
AL475_RS09830	COG0708	Exodeoxyribonuclease III
AL475_RS09835	COG4160	amino acid transport
AL475_RS09860	COG1882	Formate acetyltransferase
AL475_RS09875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL475_RS09885	COG3013	Belongs to the UPF0304 family
AL475_RS09895	COG2766	serine protein kinase
AL475_RS09900	COG2718	Belongs to the UPF0229 family
AL475_RS09905	COG2719	SpoVR family
AL475_RS09910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL475_RS09925	COG1132	(ABC) transporter
AL475_RS09930	COG0658	competence protein
AL475_RS09930	COG2333	competence protein COMEC
AL475_RS09940	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL475_RS09945	COG1136	(ABC) transporter
AL475_RS09950	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL475_RS09960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL475_RS09975	COG1252	NADH dehydrogenase
AL475_RS09980	COG3150	esterase
AL475_RS10005	COG0537	adenosine 5'-monophosphoramidase activity
AL475_RS10020	COG2186	Transcriptional regulator
AL475_RS10025	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL475_RS10030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL475_RS10035	COG1674	ftsk spoiiie
AL475_RS10040	COG1522	sequence-specific DNA binding
AL475_RS10045	COG0686	Belongs to the AlaDH PNT family
AL475_RS10055	COG0583	DNA-binding transcription factor activity
AL475_RS10070	COG0284	orotidine-5'-phosphate decarboxylase activity
AL475_RS10075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL475_RS10080	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL475_RS10085	COG0776	regulation of translation
AL475_RS10090	COG0539	negative regulation of cytoplasmic translation
AL475_RS10095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL475_RS10100	COG1555	photosystem II stabilization
AL475_RS10105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL475_RS10110	COG0776	regulation of translation
AL475_RS10115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL475_RS10120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL475_RS10130	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL475_RS10140	COG4191	Histidine kinase
AL475_RS10145	COG2204	response regulator
AL475_RS10150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL475_RS10155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL475_RS10160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL475_RS10185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL475_RS10190	COG1760	l-serine dehydratase
AL475_RS10200	COG3153	acetyltransferase
AL475_RS10200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL475_RS10210	COG5001	Diguanylate cyclase
AL475_RS10210	COG1716	ATPase activity
AL475_RS10220	COG4589	Belongs to the CDS family
AL475_RS10255	COG2197	response regulator
AL475_RS10260	COG3851	Histidine kinase
AL475_RS10265	COG2271	Major facilitator Superfamily
AL475_RS10270	COG1840	ABC-type Fe3 transport system, periplasmic component
AL475_RS10280	COG3842	ATPase activity
AL475_RS10370	COG3550	peptidyl-serine autophosphorylation
AL475_RS10390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_RS10395	COG0569	domain protein
AL475_RS10400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_RS10405	COG0745	RESPONSE REGULATOR receiver
AL475_RS10410	COG2205	protein histidine kinase activity
AL475_RS10415	COG0668	transmembrane transport
AL475_RS10420	COG1477	protein flavinylation
AL475_RS10430	COG1968	undecaprenyl-diphosphatase activity
AL475_RS10435	COG1742	UPF0060 membrane protein
AL475_RS10440	COG1280	lysine exporter protein (LysE YggA)
AL475_RS10450	COG1279	arginine transmembrane transporter activity
AL475_RS10465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL475_RS10470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL475_RS10480	COG2951	lytic endotransglycosylase activity
AL475_RS10485	COG3100	YcgL domain-containing protein
AL475_RS10500	COG2894	cell division
AL475_RS10505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL475_RS10515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL475_RS10520	COG0318	PFAM AMP-dependent synthetase and ligase
AL475_RS10540	COG1214	PFAM Peptidase M22, glycoprotease
AL475_RS10545	COG1199	ATP-dependent helicase activity
AL475_RS10555	COG0788	formyltetrahydrofolate deformylase activity
AL475_RS10560	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL475_RS10560	COG1902	pentaerythritol trinitrate reductase activity
AL475_RS10565	COG0616	signal peptide processing
AL475_RS10570	COG0252	asparaginase activity
AL475_RS10575	COG3139	Protein of unknown function (DUF1315)
AL475_RS10585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL475_RS10590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL475_RS10600	COG2226	methyltransferase
AL475_RS10620	COG2983	Belongs to the UPF0260 family
AL475_RS10630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL475_RS10635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL475_RS10640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL475_RS10650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL475_RS10655	COG2832	Protein of unknown function (DUF454)
AL475_RS10665	COG0745	RESPONSE REGULATOR receiver
AL475_RS10670	COG0583	DNA-binding transcription factor activity
AL475_RS10675	COG0778	Nitroreductase
AL475_RS10680	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL475_RS10680	COG1024	Enoyl-CoA hydratase
AL475_RS10685	COG0183	Belongs to the thiolase family
AL475_RS10700	COG2067	long-chain fatty acid transport protein
AL475_RS10705	COG2067	long-chain fatty acid transport protein
AL475_RS10710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL475_RS10725	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL475_RS10730	COG2982	Protein involved in outer membrane biogenesis
AL475_RS10735	COG0572	uridine kinase
AL475_RS10740	COG0489	protein tyrosine kinase activity
AL475_RS10745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL475_RS10745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL475_RS10755	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL475_RS10765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL475_RS10765	COG0517	IMP dehydrogenase activity
AL475_RS10765	COG0617	tRNA 3'-terminal CCA addition
AL475_RS10770	COG3706	GGDEF domain
AL475_RS10775	COG0314	molybdopterin synthase activity
AL475_RS10780	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL475_RS10785	COG0315	cyclic pyranopterin monophosphate synthase activity
AL475_RS10790	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL475_RS10795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL475_RS10800	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL475_RS10805	COG2198	Histidine kinase
AL475_RS10810	COG2204	response regulator
AL475_RS10815	COG0556	nucleotide-excision repair
AL475_RS10825	COG4657	Part of a membrane complex involved in electron transport
AL475_RS10830	COG2878	Part of a membrane complex involved in electron transport
AL475_RS10840	COG4658	electron transport chain
AL475_RS10845	COG4659	FMN binding
AL475_RS10850	COG4660	Part of a membrane complex involved in electron transport
AL475_RS10855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL475_RS10860	COG0346	lactoylglutathione lyase activity
AL475_RS10875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL475_RS10880	COG2056	Na+-H+ antiporter family
AL475_RS10885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL475_RS10890	COG1286	toxin biosynthetic process
AL475_RS10895	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL475_RS10900	COG0285	dihydrofolate synthase activity
AL475_RS10905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL475_RS10910	COG0101	tRNA pseudouridine synthase activity
AL475_RS10925	COG1263	PTS System
AL475_RS10925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL475_RS10925	COG2190	(PTS) system
AL475_RS10930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL475_RS10935	COG1846	Transcriptional regulator
AL475_RS10935	COG1940	carbohydrate kinase activity
AL475_RS10940	COG4651	solute:proton antiporter activity
AL475_RS10940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL475_RS10945	COG0367	asparagine synthase
AL475_RS10955	COG3104	oligopeptide transport
AL475_RS10960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL475_RS10970	COG0326	Molecular chaperone. Has ATPase activity
AL475_RS10975	COG3710	Transcriptional regulator
AL475_RS10990	COG0622	Phosphoesterase
AL475_RS11015	COG1090	epimerase
AL475_RS11020	COG0300	oxidoreductase activity
AL475_RS11030	COG3118	belongs to the thioredoxin family
AL475_RS11035	COG0330	HflC and HflK could
AL475_RS11045	COG0789	Transcriptional regulator
AL475_RS11060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL475_RS11065	COG3115	cell septum assembly
AL475_RS11070	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL475_RS11075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL475_RS11085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_RS11095	COG2190	(PTS) system
AL475_RS11100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL475_RS11105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL475_RS11110	COG1702	phosphate starvation-inducible protein PhoH
AL475_RS11115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL475_RS11120	COG4535	Mg2 and Co2 transporter CorC
AL475_RS11125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL475_RS11130	COG2888	peptidyl-tyrosine sulfation
AL475_RS11140	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL475_RS11145	COG1466	dna polymerase III delta subunit
AL475_RS11150	COG0799	negative regulation of ribosome biogenesis
AL475_RS11155	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL475_RS11160	COG0768	penicillin binding
AL475_RS11165	COG0772	Belongs to the SEDS family
AL475_RS11170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL475_RS11175	COG1686	Belongs to the peptidase S11 family
AL475_RS11180	COG2921	Belongs to the UPF0250 family
AL475_RS11185	COG0321	lipoyl(octanoyl) transferase activity
AL475_RS11190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL475_RS11200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL475_RS11210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL475_RS11215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_RS11255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL475_RS11260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL475_RS11265	COG2011	ABC-type metal ion transport system permease component
AL475_RS11270	COG1464	Belongs to the NlpA lipoprotein family
AL475_RS11275	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL475_RS11285	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL475_RS11285	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL475_RS11300	COG1611	Belongs to the LOG family
AL475_RS11305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL475_RS11315	COG2363	Small membrane protein
AL475_RS11325	COG0583	DNA-binding transcription factor activity
AL475_RS11330	COG0301	tRNA thio-modification
AL475_RS11330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL475_RS11340	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL475_RS11345	COG1722	exodeoxyribonuclease VII activity
AL475_RS11350	COG0142	geranyltranstransferase activity
AL475_RS11355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL475_RS11360	COG0564	pseudouridine synthase activity
AL475_RS11365	COG3098	single-species biofilm formation
AL475_RS11390	COG1671	Belongs to the UPF0178 family
AL475_RS11395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL475_RS11400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL475_RS11405	COG0254	rRNA binding
AL475_RS11410	COG1720	tRNA m6t6A37 methyltransferase activity
AL475_RS11415	COG0442	prolyl-tRNA aminoacylation
AL475_RS11440	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL475_RS11445	COG0590	tRNA wobble adenosine to inosine editing
AL475_RS11450	COG0583	DNA-binding transcription factor activity
AL475_RS11455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL475_RS11465	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL475_RS11495	COG0484	heat shock protein binding
AL475_RS11500	COG0443	Heat shock 70 kDa protein
AL475_RS11510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL475_RS11515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL475_RS11520	COG0497	DNA recombination
AL475_RS11525	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL475_RS11530	COG2914	Belongs to the UPF0125 (RnfH) family
AL475_RS11535	COG2867	negative regulation of translational initiation
AL475_RS11540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL475_RS11550	COG0582	viral genome integration into host DNA
AL475_RS11570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL475_RS11585	COG2003	Belongs to the UPF0758 family
AL475_RS11620	COG1479	Protein of unknown function DUF262
AL475_RS11655	COG0328	RNA-DNA hybrid ribonuclease activity
AL475_RS11725	COG0583	DNA-binding transcription factor activity
AL475_RS11735	COG1115	amino acid carrier protein
AL475_RS11745	COG1473	amidohydrolase
AL475_RS11760	COG1584	GPR1 FUN34 yaaH family protein
AL475_RS11780	COG0210	DNA helicase
AL475_RS11840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL475_RS11845	COG0582	viral genome integration into host DNA
AL475_RS11850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL475_RS11850	COG0519	Catalyzes the synthesis of GMP from XMP
AL475_RS11855	COG0517	IMP dehydrogenase activity
AL475_RS11855	COG0516	GMP reductase activity
AL475_RS11860	COG1570	exodeoxyribonuclease VII activity
AL475_RS11875	COG1160	GTP binding
AL475_RS11880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL475_RS11885	COG2976	Protein conserved in bacteria
AL475_RS11890	COG0124	histidyl-tRNA synthetase
AL475_RS11895	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL475_RS11910	COG0105	UTP biosynthetic process
AL475_RS11915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL475_RS11920	COG2975	iron-sulfur cluster assembly
AL475_RS11925	COG0633	Ferredoxin
AL475_RS11930	COG0443	Heat shock 70 kDa protein
AL475_RS11945	COG0822	iron-sulfur transferase activity
AL475_RS11950	COG1104	cysteine desulfurase activity
AL475_RS11955	COG1959	2 iron, 2 sulfur cluster binding
AL475_RS11960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL475_RS11965	COG0483	inositol monophosphate 1-phosphatase activity
AL475_RS11970	COG1335	isochorismatase
AL475_RS11975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL475_RS11980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL475_RS11985	COG1862	Preprotein translocase
AL475_RS11995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL475_RS12000	COG0517	IMP dehydrogenase activity
AL475_RS12010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL475_RS12015	COG0583	DNA-binding transcription factor activity
AL475_RS12020	COG0450	alkyl hydroperoxide reductase
AL475_RS12035	COG0704	Plays a role in the regulation of phosphate uptake
AL475_RS12040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL475_RS12045	COG0581	inorganic phosphate transmembrane transporter activity
AL475_RS12050	COG0573	inorganic phosphate transmembrane transporter activity
AL475_RS12060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL475_RS12065	COG0248	Ppx GppA phosphatase
AL475_RS12075	COG5002	protein histidine kinase activity
AL475_RS12080	COG0745	RESPONSE REGULATOR receiver
AL475_RS12090	COG0826	peptidase U32
AL475_RS12095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL475_RS12100	COG0477	Major facilitator Superfamily
AL475_RS12110	COG1595	DNA-templated transcription, initiation
AL475_RS12120	COG3248	Nucleoside-binding outer membrane protein
AL475_RS12125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL475_RS12130	COG0693	protein deglycase activity
AL475_RS12135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL475_RS12145	COG2166	iron-sulfur cluster assembly
AL475_RS12150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL475_RS12155	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL475_RS12165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL475_RS12165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL475_RS12175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL475_RS12180	COG1074	ATP-dependent DNA helicase activity
AL475_RS12185	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL475_RS12200	COG3141	response to X-ray
AL475_RS12205	COG2171	N-acyltransferase activity
AL475_RS12210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL475_RS12225	COG0569	domain protein
AL475_RS12225	COG0189	ligase activity
AL475_RS12240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL475_RS12245	COG2017	converts alpha-aldose to the beta-anomer
AL475_RS12255	COG2059	Chromate
AL475_RS12260	COG0784	Response regulator, receiver
AL475_RS12260	COG3437	response regulator, receiver
AL475_RS12310	COG4964	Belongs to the GSP D family
AL475_RS12350	COG0583	DNA-binding transcription factor activity
AL475_RS12360	COG0583	DNA-binding transcription factor activity
AL475_RS12365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL475_RS12370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL475_RS12380	COG0560	Phosphoserine phosphatase
AL475_RS12390	COG0813	purine-nucleoside phosphorylase activity
AL475_RS12395	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL475_RS12400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL475_RS12405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL475_RS12415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL475_RS12420	COG1744	ABC transporter substrate-binding protein PnrA-like
AL475_RS12425	COG3845	ABC transporter
AL475_RS12430	COG4603	Belongs to the binding-protein-dependent transport system permease family
AL475_RS12435	COG1079	Belongs to the binding-protein-dependent transport system permease family
AL475_RS12440	COG0084	hydrolase, TatD family'
AL475_RS12445	COG3022	response to hydroperoxide
AL475_RS12450	COG1115	amino acid carrier protein
AL475_RS12465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL475_RS12475	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL475_RS12480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL475_RS12485	COG0083	homoserine kinase activity
AL475_RS12505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL475_RS12520	COG0745	RESPONSE REGULATOR receiver
AL475_RS12530	COG5002	protein histidine kinase activity
AL475_RS12530	COG2198	Histidine kinase
AL475_RS12530	COG0784	Response regulator, receiver
AL475_RS12535	COG2203	Gaf domain
AL475_RS12535	COG3706	GGDEF domain
AL475_RS12535	COG4251	negative regulation of phosphorylation
AL475_RS12535	COG5001	Diguanylate cyclase
AL475_RS12540	COG1242	4 iron, 4 sulfur cluster binding
AL475_RS12545	COG0069	glutamate synthase activity
AL475_RS12545	COG0070	glutamate synthase
AL475_RS12545	COG0067	glutamate synthase
AL475_RS12555	COG0067	glutamate synthase
AL475_RS12555	COG0069	glutamate synthase activity
AL475_RS12555	COG0070	glutamate synthase
AL475_RS12560	COG0493	'glutamate synthase
AL475_RS12570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL475_RS12580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL475_RS12585	COG2860	membrane
AL475_RS12605	COG0583	DNA-binding transcription factor activity
AL475_RS12610	COG0730	response to heat
AL475_RS12615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL475_RS12620	COG0505	Belongs to the CarA family
AL475_RS12625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL475_RS12630	COG0494	nUDIX hydrolase
AL475_RS12635	COG0653	protein targeting
AL475_RS12645	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL475_RS12650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL475_RS12655	COG0849	cell division
AL475_RS12660	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL475_RS12665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL475_RS12670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL475_RS12675	COG0772	Belongs to the SEDS family
AL475_RS12680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL475_RS12690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL475_RS12695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL475_RS12700	COG0768	penicillin binding
AL475_RS12705	COG3116	cell division
AL475_RS12720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL475_RS12725	COG3107	peptidoglycan biosynthetic process
AL475_RS12730	COG0792	nuclease activity
AL475_RS12735	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL475_RS12740	COG2823	Periplasmic or secreted lipoprotein
AL475_RS12745	COG2969	positive regulation of protein catabolic process
AL475_RS12750	COG0625	glutathione transferase activity
AL475_RS12755	COG2857	Cytochrome c1
AL475_RS12760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL475_RS12765	COG0723	plastoquinol--plastocyanin reductase activity
AL475_RS12770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL475_RS12775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL475_RS12785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL475_RS12790	COG3105	Protein conserved in bacteria
AL475_RS12795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL475_RS12800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL475_RS12805	COG0335	large ribosomal subunit rRNA binding
AL475_RS12810	COG0336	Belongs to the RNA methyltransferase TrmD family
AL475_RS12815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL475_RS12825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL475_RS12830	COG4137	Cytochrome C assembly protein
AL475_RS12835	COG4536	flavin adenine dinucleotide binding
AL475_RS12840	COG1854	S-ribosylhomocysteine lyase activity
AL475_RS12855	COG0612	Peptidase, M16
AL475_RS12860	COG1238	metal cluster binding
AL475_RS12870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL475_RS12875	COG5016	pyruvate
AL475_RS12875	COG0511	ligase activity, forming carbon-carbon bonds
AL475_RS12880	COG3630	sodium ion export across plasma membrane
AL475_RS12930	COG0527	aspartate kinase activity
AL475_RS12935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL475_RS12945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL475_RS12950	COG1546	Belongs to the CinA family
AL475_RS12955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL475_RS12960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL475_RS12965	COG4942	peptidase
AL475_RS12965	COG1388	LysM domain
AL475_RS12975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL475_RS12980	COG0585	pseudouridine synthase activity
AL475_RS12990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL475_RS12995	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL475_RS13000	COG1968	undecaprenyl-diphosphatase activity
AL475_RS13005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL475_RS13010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL475_RS13015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL475_RS13020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL475_RS13025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL475_RS13030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL475_RS13035	COG1610	YqeY-like protein
AL475_RS13055	COG0582	viral genome integration into host DNA
AL475_RS13075	COG2203	Gaf domain
AL475_RS13075	COG5001	Diguanylate cyclase
AL475_RS13075	COG4251	negative regulation of phosphorylation
AL475_RS13075	COG3706	GGDEF domain
AL475_RS13110	COG3706	GGDEF domain
AL475_RS13120	COG2003	Belongs to the UPF0758 family
AL475_RS13175	COG0668	transmembrane transport
AL475_RS13185	COG1968	undecaprenyl-diphosphatase activity
AL475_RS13215	COG0328	RNA-DNA hybrid ribonuclease activity
AL475_RS13270	COG2239	Acts as a magnesium transporter
AL475_RS13290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_RS13295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL475_RS13300	COG1349	DNA-binding transcription factor activity
AL475_RS13315	COG3706	GGDEF domain
AL475_RS13340	COG0668	transmembrane transport
AL475_RS13345	COG0191	fructose-bisphosphate aldolase activity
AL475_RS13350	COG0126	phosphoglycerate kinase activity
AL475_RS13355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL475_RS13360	COG4771	TonB-dependent receptor
AL475_RS13365	COG0583	DNA-binding transcription factor activity
AL475_RS13370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL475_RS13375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL475_RS13390	COG2356	endonuclease I
AL475_RS13395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL475_RS13400	COG0189	ligase activity
AL475_RS13405	COG1678	Uncharacterized ACR, COG1678
AL475_RS13410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL475_RS13425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL475_RS13430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL475_RS13435	COG0762	integral membrane protein
AL475_RS13440	COG1872	DUF167
AL475_RS13450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL475_RS13455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL475_RS13460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL475_RS13465	COG2066	Belongs to the glutaminase family
AL475_RS13470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL475_RS13475	COG1194	a g-specific adenine glycosylase
AL475_RS13480	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL475_RS13485	COG0741	lytic transglycosylase activity
AL475_RS13540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL475_RS13545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL475_RS13550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL475_RS13555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL475_RS13560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL475_RS13565	COG2967	ApaG domain
AL475_RS13580	COG3610	response to peptide
AL475_RS13585	COG2966	Psort location CytoplasmicMembrane, score
AL475_RS13590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL475_RS13600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL475_RS13605	COG0142	geranyltranstransferase activity
AL475_RS13610	COG0531	amino acid
AL475_RS13615	COG0039	L-malate dehydrogenase activity
AL475_RS13620	COG1438	arginine binding
AL475_RS13635	COG0589	response to stress
AL475_RS13655	COG0312	modulator of DNA gyrase
AL475_RS13660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL475_RS13665	COG3164	Protein of unknown function
AL475_RS13670	COG1530	ribonuclease E activity
AL475_RS13675	COG0424	maF-like protein
AL475_RS13680	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL475_RS13685	COG1792	Involved in formation and maintenance of cell shape
AL475_RS13690	COG1077	Cell shape determining protein MreB Mrl
AL475_RS13725	COG2165	general secretion pathway protein
AL475_RS13735	COG1459	type II secretion system
AL475_RS13740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL475_RS13750	COG3409	Peptidoglycan-binding domain 1 protein
AL475_RS13750	COG3267	Type II secretory pathway component ExeA
AL475_RS13775	COG2200	EAL domain
AL475_RS13775	COG2199	diguanylate cyclase activity
AL475_RS13780	COG0629	single-stranded DNA binding
AL475_RS13795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL475_RS13805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL475_RS13810	COG0527	aspartate kinase activity
AL475_RS13815	COG0646	methionine synthase
AL475_RS13815	COG1410	methionine synthase
AL475_RS13895	COG0175	sulfate reduction
AL475_RS13925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL475_RS13930	COG0735	belongs to the Fur family
AL475_RS13940	COG0166	Belongs to the GPI family
AL475_RS13950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL475_RS13965	COG0359	binds to the 23S rRNA
AL475_RS13975	COG2965	DNA replication, synthesis of RNA primer
AL475_RS13980	COG0360	Binds together with S18 to 16S ribosomal RNA
AL475_RS13990	COG2906	2 iron, 2 sulfur cluster binding
AL475_RS14000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL475_RS14005	COG0049	tRNA binding
AL475_RS14015	COG2168	tRNA wobble position uridine thiolation
AL475_RS14020	COG2923	Belongs to the DsrF TusC family
AL475_RS14030	COG2964	Protein conserved in bacteria
AL475_RS14035	COG0545	Peptidyl-prolyl cis-trans isomerase
AL475_RS14045	COG2900	Belongs to the SlyX family
AL475_RS14050	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL475_RS14055	COG0330	HflC and HflK could
AL475_RS14060	COG0330	HflC and HflK could
AL475_RS14065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL475_RS14070	COG1923	regulation of RNA biosynthetic process
AL475_RS14075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL475_RS14080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL475_RS14090	COG0802	atpase or kinase
AL475_RS14095	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL475_RS14145	COG1162	GTPase activity
AL475_RS14150	COG0688	phosphatidylethanolamine metabolic process
AL475_RS14155	COG0490	domain, Protein
AL475_RS14155	COG0471	metal ion transport
AL475_RS14170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL475_RS14175	COG4942	peptidase
AL475_RS14190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL475_RS14195	COG2816	NAD+ diphosphatase activity
AL475_RS14200	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL475_RS14205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL475_RS14210	COG0085	RNA polymerase activity
AL475_RS14215	COG0222	ribosome binding
AL475_RS14220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL475_RS14230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL475_RS14235	COG0250	Participates in transcription elongation, termination and antitermination
AL475_RS14240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL475_RS14275	COG1072	(Pantothenic acid kinase))
AL475_RS14285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL475_RS14295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL475_RS14360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL475_RS14375	COG3118	belongs to the thioredoxin family
AL475_RS14380	COG0513	Belongs to the DEAD box helicase family
AL475_RS14385	COG0248	Ppx GppA phosphatase
AL475_RS14390	COG2198	Histidine kinase
AL475_RS14390	COG0784	Response regulator, receiver
AL475_RS14390	COG2205	protein histidine kinase activity
AL475_RS14395	COG2814	Major facilitator Superfamily
AL475_RS14410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL475_RS14415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL475_RS14420	COG0511	ligase activity, forming carbon-carbon bonds
AL475_RS14425	COG0439	Biotin carboxylase
AL475_RS14430	COG2264	protein methyltransferase activity
AL475_RS14435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL475_RS14440	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL475_RS14445	COG0840	transmembrane signaling receptor activity
AL475_RS14450	COG0789	Transcriptional regulator
AL475_RS14460	COG0138	bifunctional purine biosynthesis protein purh
AL475_RS14465	COG0151	Belongs to the GarS family
AL475_RS14475	COG0776	regulation of translation
AL475_RS14480	COG1253	flavin adenine dinucleotide binding
AL475_RS14485	COG0668	transmembrane transport
AL475_RS14490	COG3068	Protein conserved in bacteria
AL475_RS14495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL475_RS14500	COG1573	uracil-dna glycosylase
AL475_RS14505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL475_RS14515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL475_RS14575	COG1086	Polysaccharide biosynthesis protein
AL475_RS14580	COG0438	transferase activity, transferring glycosyl groups
AL475_RS14585	COG2264	protein methyltransferase activity
AL475_RS14610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL475_RS14620	COG1560	Kdo2-lipid A biosynthetic process
AL475_RS14625	COG3307	-O-antigen
AL475_RS14630	COG0859	PFAM glycosyl transferase family 9
AL475_RS14635	COG0859	PFAM glycosyl transferase family 9
AL475_RS14640	COG1519	Transferase
AL475_RS14645	COG0438	transferase activity, transferring glycosyl groups
AL475_RS14650	COG3642	lipopolysaccharide core region biosynthetic process
AL475_RS14655	COG0859	PFAM glycosyl transferase family 9
AL475_RS14660	COG0463	Glycosyl transferase, family 2
AL475_RS14665	COG0438	transferase activity, transferring glycosyl groups
AL475_RS14670	COG0438	transferase activity, transferring glycosyl groups
AL475_RS14675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL475_RS14690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL475_RS14700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL475_RS14705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL475_RS14710	COG2003	Belongs to the UPF0758 family
AL475_RS14725	COG1309	transcriptional regulator
AL475_RS14730	COG1560	Kdo2-lipid A biosynthetic process
AL475_RS14735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL475_RS14740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL475_RS14745	COG1561	YicC-like family, N-terminal region
AL475_RS14750	COG2862	Uncharacterized protein family, UPF0114
AL475_RS14765	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL475_RS14770	COG1120	ATPase activity
AL475_RS14775	COG1132	(ABC) transporter
AL475_RS14790	COG0514	ATP-dependent DNA helicase (RecQ)
AL475_RS14795	COG2962	Rard protein
AL475_RS14805	COG1280	lysine exporter protein (LysE YggA)
AL475_RS14810	COG0405	Gamma-glutamyltransferase
AL475_RS14815	COG0210	DNA helicase
AL475_RS14850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL475_RS14855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL475_RS14870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_RS14875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL475_RS14885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_RS14890	COG0601	transmembrane transport
AL475_RS14895	COG0747	negative chemotaxis
AL475_RS14935	COG0210	DNA helicase
AL475_RS14945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_RS14950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL475_RS14955	COG2960	long-chain fatty acid transporting porin activity
AL475_RS14960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL475_RS14965	COG0583	DNA-binding transcription factor activity
AL475_RS15015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL475_RS15025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL475_RS15030	COG0408	coproporphyrinogen oxidase activity
AL475_RS15040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL475_RS15045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL475_RS15050	COG0551	DNA topoisomerase type I activity
AL475_RS15055	COG2922	Belongs to the Smg family
AL475_RS15060	COG0758	DNA mediated transformation
AL475_RS15065	COG1652	LysM domain
AL475_RS15070	COG0242	peptide deformylase activity
AL475_RS15080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL475_RS15080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL475_RS15085	COG0569	domain protein
AL475_RS15090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_RS15100	COG1272	protein, Hemolysin III
AL475_RS15105	COG4326	sporulation control protein
AL475_RS15115	COG3084	Protein conserved in bacteria
AL475_RS15125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL475_RS15130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL475_RS15135	COG0204	Acyl-transferase
AL475_RS15140	COG0606	chelatase, subunit chli
AL475_RS15150	COG3978	acetolactate synthase activity
AL475_RS15155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL475_RS15170	COG0604	alcohol dehydrogenase
AL475_RS15185	COG0425	Belongs to the sulfur carrier protein TusA family
AL475_RS15195	COG2119	membrane
AL475_RS15200	COG0752	glycyl-tRNA synthetase alpha subunit
AL475_RS15205	COG0751	glycine-tRNA ligase activity
AL475_RS15210	COG3977	Valine--pyruvate aminotransferase
AL475_RS15215	COG0071	Belongs to the small heat shock protein (HSP20) family
AL475_RS15220	COG0187	DNA topoisomerase II activity
AL475_RS15225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL475_RS15230	COG0592	DNA-directed DNA polymerase activity
AL475_RS15235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL475_RS15250	COG1126	abc transporter atp-binding protein
AL475_RS15255	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL475_RS15270	COG0706	membrane insertase activity
AL475_RS15280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL475_RS15285	COG0445	tRNA wobble uridine modification
AL475_RS15290	COG0357	Ribosomal RNA small subunit methyltransferase G
AL475_RS15295	COG1192	Involved in chromosome partitioning
AL475_RS15300	COG1475	DNA binding
AL475_RS15305	COG3312	ion transport
AL475_RS15320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL475_RS15325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL475_RS15330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL475_RS15335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL475_RS15340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL475_RS15345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL475_RS15355	COG0765	amino acid transport
AL475_RS15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_RS15365	COG2814	Major facilitator Superfamily
AL475_RS15370	COG0583	DNA-binding transcription factor activity
AL475_RS15375	COG0183	Belongs to the thiolase family
AL475_RS15385	COG1739	Uncharacterized protein family UPF0029
AL475_RS15390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_RS15445	COG2132	Multicopper oxidase
AL475_RS15450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL475_RS15455	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL475_RS15460	COG0352	thiamine-phosphate diphosphorylase activity
AL475_RS15465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL475_RS15475	COG2022	thiamine diphosphate biosynthetic process
AL475_RS15480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL475_RS15485	COG0517	IMP dehydrogenase activity
AL475_RS15485	COG4175	Glycine betaine
AL475_RS15505	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS15510	COG1309	transcriptional regulator
AL475_RS15515	COG0006	proline dipeptidase activity
AL475_RS15515	COG0006	proline dipeptidase activity
AL475_RS15535	COG1522	sequence-specific DNA binding
AL475_RS15540	COG5002	protein histidine kinase activity
AL475_RS15540	COG5001	Diguanylate cyclase
AL475_RS15555	COG0697	spore germination
AL475_RS15560	COG0589	response to stress
AL475_RS15565	COG1528	Iron-storage protein
AL475_RS15575	COG2081	HI0933 family
AL475_RS15580	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL475_RS15585	COG1129	ABC transporter
AL475_RS15590	COG1879	ABC-type sugar transport system periplasmic component
AL475_RS15595	COG1069	ribulokinase activity
AL475_RS15600	COG0235	Class ii aldolase
AL475_RS15605	COG2160	L-arabinose isomerase activity
AL475_RS15630	COG1322	Protein conserved in bacteria
AL475_RS15635	COG2226	methyltransferase
AL475_RS15640	COG3165	ubiquinone biosynthetic process from chorismate
AL475_RS15645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL475_RS15650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL475_RS15655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL475_RS15660	COG0805	protein transport
AL475_RS15665	COG0084	hydrolase, TatD family'
AL475_RS15675	COG0456	acetyltransferase
AL475_RS15680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL475_RS15680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL475_RS15715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL475_RS15720	COG3071	HemY protein
AL475_RS15725	COG2959	enzyme of heme biosynthesis
AL475_RS15730	COG1587	Uroporphyrinogen-III synthase
AL475_RS15740	COG3072	Adenylate cyclase
AL475_RS15745	COG1965	Belongs to the frataxin family
AL475_RS15755	COG0019	diaminopimelate decarboxylase activity
AL475_RS15760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL475_RS15770	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL475_RS15775	COG1011	Hydrolase
AL475_RS15780	COG2199	diguanylate cyclase activity
AL475_RS15780	COG3287	FIST C domain
AL475_RS15780	COG2200	EAL domain
AL475_RS15785	COG3148	PFAM DTW domain containing protein
AL475_RS15800	COG0561	phosphatase activity
AL475_RS15805	COG2267	carboxylic ester hydrolase activity
AL475_RS15810	COG1280	lysine exporter protein (LysE YggA)
AL475_RS15815	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL475_RS15820	COG0640	Transcriptional regulator
AL475_RS15825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL475_RS15840	COG0783	Belongs to the Dps family
AL475_RS15875	COG2095	MarC family integral membrane protein
AL475_RS15885	COG0742	ribosomal rna small subunit methyltransferase
AL475_RS15890	COG0552	protein localization to endoplasmic reticulum
AL475_RS15895	COG2884	Cell division ATP-binding protein ftsE
AL475_RS15900	COG2177	Part of the ABC transporter FtsEX involved in
AL475_RS15905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL475_RS15910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL475_RS15915	COG0705	Rhomboid family
AL475_RS15920	COG1580	Controls the rotational direction of flagella during chemotaxis
AL475_RS15925	COG3161	chorismate lyase activity
AL475_RS15930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL475_RS15935	COG2937	Belongs to the GPAT DAPAT family
AL475_RS15940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL475_RS15945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL475_RS15955	COG0534	Mate efflux family protein
AL475_RS15960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL475_RS15975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL475_RS15990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL475_RS16050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL475_RS16055	COG3300	MHYT domain
AL475_RS16055	COG5001	Diguanylate cyclase
AL475_RS16060	COG2204	response regulator
AL475_RS16065	COG3852	Histidine kinase
AL475_RS16075	COG0174	glutamine synthetase
AL475_RS16080	COG1217	gtp-binding protein TYPA
AL475_RS16100	COG1490	D-aminoacyl-tRNA deacylase activity
AL475_RS16105	COG0456	acetyltransferase
AL475_RS16110	COG2982	Protein involved in outer membrane biogenesis
AL475_RS16115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL475_RS16125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL475_RS16130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL475_RS16135	COG3031	protein transport across the cell outer membrane
AL475_RS16145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL475_RS16150	COG1459	type II secretion system
AL475_RS16155	COG2165	general secretion pathway protein
AL475_RS16160	COG2165	general secretion pathway protein
AL475_RS16165	COG2165	general secretion pathway protein
AL475_RS16170	COG4795	General secretion pathway protein
AL475_RS16175	COG3156	type II secretion system protein K
AL475_RS16180	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL475_RS16185	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL475_RS16195	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL475_RS16200	COG0494	nUDIX hydrolase
AL475_RS16210	COG1040	competence protein
AL475_RS16225	COG2183	response to ionizing radiation
AL475_RS16235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL475_RS16240	COG1609	Transcriptional regulator
AL475_RS16245	COG0129	dihydroxy-acid dehydratase activity
AL475_RS16250	COG3265	gluconokinase activity
AL475_RS16255	COG2610	gluconate transmembrane transporter activity
AL475_RS16260	COG0800	Aldolase
AL475_RS16275	COG2233	PERMEase
AL475_RS16280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL475_RS16285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL475_RS16290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL475_RS16295	COG1758	RNA polymerase activity
AL475_RS16300	COG0194	GDP metabolic process
AL475_RS16305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL475_RS16310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL475_RS16330	COG4232	protein-disulfide reductase activity
AL475_RS16340	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL475_RS16345	COG0540	Belongs to the ATCase OTCase family
AL475_RS16355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL475_RS16370	COG1288	antiporter activity
AL475_RS16375	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL475_RS16380	COG1027	Aspartate ammonia-lyase
AL475_RS16390	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL475_RS16395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL475_RS16400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL475_RS16405	COG2205	protein histidine kinase activity
AL475_RS16410	COG0745	RESPONSE REGULATOR receiver
AL475_RS16415	COG3678	ATP-independent chaperone mediated protein folding
AL475_RS16420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL475_RS16425	COG0205	6-phosphofructokinase activity
AL475_RS16430	COG1494	fructose-1,6-bisphosphatase
AL475_RS16435	COG3074	FtsZ-dependent cytokinesis
AL475_RS16440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL475_RS16445	COG0460	homoserine dehydrogenase
AL475_RS16445	COG0527	aspartate kinase activity
AL475_RS16450	COG0626	cystathionine gamma-synthase activity
AL475_RS16455	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL475_RS16460	COG0281	malic enzyme
AL475_RS16465	COG0254	rRNA binding
AL475_RS16470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL475_RS16475	COG1609	Transcriptional regulator
AL475_RS16485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL475_RS16490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL475_RS16495	COG1575	Belongs to the MenA family. Type 1 subfamily
AL475_RS16500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL475_RS16505	COG0534	Mate efflux family protein
AL475_RS16510	COG0149	triose-phosphate isomerase activity
AL475_RS16540	COG0459	protein refolding
AL475_RS16545	COG1119	ATPase activity
AL475_RS16555	COG1285	pathogenesis
AL475_RS16560	COG1509	lysine 2,3-aminomutase activity
AL475_RS16565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL475_RS16575	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL475_RS16580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL475_RS16585	COG1053	succinate dehydrogenase
AL475_RS16595	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL475_RS16600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL475_RS16605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL475_RS16610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL475_RS16615	COG1045	serine acetyltransferase
AL475_RS16620	COG1695	Transcriptional regulator
AL475_RS16625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL475_RS16630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL475_RS16635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL475_RS16640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL475_RS16645	COG0137	argininosuccinate synthase activity
AL475_RS16650	COG0165	Argininosuccinate lyase
AL475_RS16650	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL475_RS16660	COG0678	peroxiredoxin activity
AL475_RS16660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL475_RS16670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL475_RS16705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL475_RS16715	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL475_RS16720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL475_RS16730	COG0180	Tryptophanyl-tRNA synthetase
AL475_RS16740	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL475_RS16750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL475_RS16760	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS16775	COG3954	Phosphoribulokinase
AL475_RS16785	COG0429	hydrolase of the alpha beta-hydrolase fold
AL475_RS16795	COG0488	(ABC) transporter
AL475_RS16800	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL475_RS16810	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AL475_RS16815	COG1047	Peptidyl-prolyl cis-trans
AL475_RS16825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL475_RS16830	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL475_RS16835	COG3083	sulfuric ester hydrolase activity
AL475_RS16840	COG0557	exoribonuclease II activity
AL475_RS16845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL475_RS16850	COG0051	transcription antitermination factor activity, RNA binding
AL475_RS16855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL475_RS16860	COG0088	Forms part of the polypeptide exit tunnel
AL475_RS16865	COG0089	rRNA binding
AL475_RS16870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL475_RS16875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL475_RS16880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL475_RS16890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL475_RS16895	COG0255	Belongs to the universal ribosomal protein uL29 family
AL475_RS16900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL475_RS16905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL475_RS16910	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL475_RS16915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL475_RS16920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL475_RS16925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL475_RS16935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL475_RS16945	COG1841	ribosomal large subunit assembly
AL475_RS16950	COG0200	Binds to the 23S rRNA
AL475_RS16955	COG0201	protein transport
AL475_RS16960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL475_RS16965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL475_RS16970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL475_RS16975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL475_RS16980	COG0202	RNA polymerase activity
AL475_RS16985	COG0203	ribosomal protein L17
AL475_RS16995	COG0545	Peptidyl-prolyl cis-trans isomerase
AL475_RS17000	COG3061	Opacity-associated protein A
AL475_RS17005	COG0697	spore germination
AL475_RS17010	COG2153	protein acetylation
AL475_RS17015	COG0513	Belongs to the DEAD box helicase family
AL475_RS17025	COG0737	Belongs to the 5'-nucleotidase family
AL475_RS17030	COG1648	precorrin-2 dehydrogenase activity
AL475_RS17030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL475_RS17035	COG0175	sulfate reduction
AL475_RS17040	COG2895	sulfate adenylyltransferase (ATP) activity
AL475_RS17045	COG0490	domain, Protein
AL475_RS17045	COG0471	metal ion transport
AL475_RS17050	COG0529	Catalyzes the synthesis of activated sulfate
AL475_RS17070	COG1136	(ABC) transporter
AL475_RS17070	COG0577	efflux transmembrane transporter activity
AL475_RS17085	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL475_RS17090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL475_RS17095	COG0729	surface antigen
AL475_RS17105	COG2105	PFAM AIG2 family protein
AL475_RS17110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL475_RS17115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL475_RS17120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL475_RS17125	COG0163	prenyltransferase activity
AL475_RS17135	COG1178	ABC-type Fe3 transport system permease component
AL475_RS17140	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL475_RS17145	COG3028	Belongs to the UPF0307 family
AL475_RS17150	COG0312	modulator of DNA gyrase
AL475_RS17155	COG2239	Acts as a magnesium transporter
AL475_RS17160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_RS17165	COG1660	Displays ATPase and GTPase activities
AL475_RS17170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_RS17175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL475_RS17185	COG1137	ATPase activity
AL475_RS17190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL475_RS17200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AL475_RS17205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL475_RS17205	COG0517	IMP dehydrogenase activity
AL475_RS17215	COG1127	ABC transporter
AL475_RS17220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL475_RS17225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL475_RS17230	COG2854	intermembrane phospholipid transfer
AL475_RS17235	COG3113	response to antibiotic
AL475_RS17240	COG5007	Belongs to the BolA IbaG family
AL475_RS17245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL475_RS17250	COG0204	Acyl-transferase
AL475_RS17255	COG0251	oxidation-reduction process
AL475_RS17265	COG0540	Belongs to the ATCase OTCase family
AL475_RS17270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL475_RS17275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL475_RS17285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL475_RS17295	COG0564	pseudouridine synthase activity
AL475_RS17300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL475_RS17305	COG0525	valine-tRNA ligase activity
AL475_RS17315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL475_RS17320	COG0795	lipopolysaccharide-transporting ATPase activity
AL475_RS17325	COG0795	lipopolysaccharide-transporting ATPase activity
AL475_RS17360	COG2203	Gaf domain
AL475_RS17360	COG2200	EAL domain
AL475_RS17360	COG2199	diguanylate cyclase activity
AL475_RS17415	COG0066	3-isopropylmalate dehydratase activity
AL475_RS17420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL475_RS17425	COG0473	3-isopropylmalate dehydrogenase activity
AL475_RS17450	COG0583	DNA-binding transcription factor activity
AL475_RS17455	COG1022	Amp-dependent synthetase and ligase
AL475_RS17460	COG0028	Belongs to the TPP enzyme family
AL475_RS17465	COG0440	acetolactate synthase activity
AL475_RS17470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL475_RS17480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL475_RS17490	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL475_RS17495	COG3079	Belongs to the UPF0149 family
AL475_RS17500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL475_RS17505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL475_RS17525	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL475_RS17535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL475_RS17540	COG1595	DNA-templated transcription, initiation
AL475_RS17555	COG3086	response to oxidative stress
AL475_RS17560	COG0481	GTPase activity
AL475_RS17570	COG0571	ribonuclease III activity
AL475_RS17575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL475_RS17580	COG1381	Involved in DNA repair and RecF pathway recombination
AL475_RS17585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL475_RS17590	COG0736	holo-[acyl-carrier-protein] synthase activity
AL475_RS17600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL475_RS17605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL475_RS17610	COG3956	TIGRFAM MazG family protein
AL475_RS17615	COG0504	CTP synthase activity
AL475_RS17620	COG0148	phosphopyruvate hydratase activity
AL475_RS17625	COG0617	tRNA 3'-terminal CCA addition
AL475_RS17630	COG3409	Peptidoglycan-binding domain 1 protein
AL475_RS17630	COG3267	Type II secretory pathway component ExeA
AL475_RS17640	COG4991	sh3 domain protein
AL475_RS17645	COG0306	phosphate transporter
AL475_RS17650	COG1392	Phosphate transport regulator
AL475_RS17655	COG3025	triphosphatase activity
AL475_RS17660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL475_RS17670	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL475_RS17675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL475_RS17675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL475_RS17680	COG1538	Outer membrane efflux protein
AL475_RS17685	COG0494	nUDIX hydrolase
AL475_RS17690	COG3151	Protein conserved in bacteria
AL475_RS17700	COG3150	esterase
AL475_RS17710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL475_RS17720	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL475_RS17735	COG1459	type II secretion system
AL475_RS17765	COG4974	Belongs to the 'phage' integrase family
AL475_RS17770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL475_RS17775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL475_RS17780	COG2186	Transcriptional regulator
AL475_RS17785	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL475_RS17790	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL475_RS17795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL475_RS17810	COG0288	reversible hydration of carbon dioxide
AL475_RS17815	COG1131	(ABC) transporter
AL475_RS17820	COG0842	Transport permease protein
AL475_RS17825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL475_RS17830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL475_RS17835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL475_RS17845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL475_RS17850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL475_RS17855	COG1489	DNA binding
AL475_RS17860	COG1643	Atp-dependent helicase
AL475_RS17865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL475_RS17870	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL475_RS17875	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL475_RS17880	COG3112	Uncharacterised protein family (UPF0231)
AL475_RS17885	COG0347	Belongs to the P(II) protein family
AL475_RS17890	COG0004	ammonium transporteR
AL475_RS17895	COG1840	ABC-type Fe3 transport system, periplasmic component
AL475_RS17905	COG3842	ATPase activity
AL475_RS17910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL475_RS17925	COG2971	BadF BadG BcrA BcrD
AL475_RS17935	COG4608	Belongs to the ABC transporter superfamily
AL475_RS17940	COG0444	Belongs to the ABC transporter superfamily
AL475_RS17945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_RS17955	COG0747	negative chemotaxis
AL475_RS17960	COG0784	Response regulator, receiver
AL475_RS17960	COG2205	protein histidine kinase activity
AL475_RS17970	COG0628	permease
AL475_RS17975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL475_RS17980	COG0316	Belongs to the HesB IscA family
AL475_RS17995	COG0739	heme binding
AL475_RS18000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL475_RS18010	COG2239	Acts as a magnesium transporter
AL475_RS18015	COG2027	D-alanyl-D-alanine carboxypeptidase
AL475_RS18020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL475_RS18025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL475_RS18030	COG1534	Rna-binding protein
AL475_RS18035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL475_RS18040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL475_RS18045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL475_RS18050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL475_RS18055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL475_RS18070	COG0779	Required for maturation of 30S ribosomal subunits
AL475_RS18075	COG0195	Participates in both transcription termination and antitermination
AL475_RS18085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL475_RS18090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL475_RS18095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL475_RS18115	COG0534	Mate efflux family protein
AL475_RS18120	COG0826	peptidase U32
AL475_RS18125	COG0826	peptidase U32
AL475_RS18135	COG3154	lipid carrier protein
AL475_RS18140	COG3153	acetyltransferase
AL475_RS18165	COG0513	Belongs to the DEAD box helicase family
AL475_RS18185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL475_RS18190	COG2204	response regulator
AL475_RS18200	COG0667	Aldo Keto reductase
AL475_RS18215	COG0494	nUDIX hydrolase
AL475_RS18225	COG0730	response to heat
AL475_RS18235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL475_RS18240	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL475_RS18245	COG0583	DNA-binding transcription factor activity
AL475_RS18250	COG0640	Transcriptional regulator
AL475_RS18255	COG0268	Binds directly to 16S ribosomal RNA
AL475_RS18260	COG0728	peptidoglycan biosynthetic process
AL475_RS18265	COG0196	riboflavin kinase activity
AL475_RS18270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL475_RS18275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL475_RS18280	COG1047	Peptidyl-prolyl cis-trans
AL475_RS18285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL475_RS18290	COG1966	Carbon starvation protein
AL475_RS18305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL475_RS18310	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL475_RS18320	COG3279	Response regulator of the LytR AlgR family
AL475_RS18325	COG3275	phosphorelay sensor kinase activity
AL475_RS18330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL475_RS18335	COG0287	Prephenate dehydrogenase
AL475_RS18335	COG1605	Chorismate mutase
AL475_RS18345	COG0488	(ABC) transporter
AL475_RS18355	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL475_RS18360	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL475_RS18365	COG5001	Diguanylate cyclase
AL475_RS18370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL475_RS18375	COG0077	Prephenate dehydratase
AL475_RS18375	COG1605	Chorismate mutase
AL475_RS18380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL475_RS18385	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL475_RS18390	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL475_RS18395	COG0564	pseudouridine synthase activity
AL475_RS18405	COG0542	response to heat
AL475_RS18415	COG0590	tRNA wobble adenosine to inosine editing
AL475_RS18420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL475_RS18505	COG0271	Belongs to the BolA IbaG family
AL475_RS18510	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL475_RS18515	COG1805	sodium ion transport
AL475_RS18525	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL475_RS18530	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL475_RS18535	COG2871	sodium ion transport
AL475_RS18540	COG1477	protein flavinylation
AL475_RS18555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL475_RS18570	COG0733	neurotransmitter:sodium symporter activity
AL475_RS18580	COG0189	ligase activity
AL475_RS18585	COG4067	protein conserved in archaea
AL475_RS18585	COG0189	ligase activity
AL475_RS18590	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL475_RS18595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_RS18600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL475_RS18610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL475_RS18620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL475_RS18625	COG2252	PERMEase
AL475_RS18630	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL475_RS18635	COG1073	alpha beta
AL475_RS18645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL475_RS18650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL475_RS18655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL475_RS18660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL475_RS18660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL475_RS18675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL475_RS18680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL475_RS18685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL475_RS18690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL475_RS18700	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL475_RS18705	COG0024	Methionine aminopeptidase
AL475_RS18710	COG0052	Belongs to the universal ribosomal protein uS2 family
AL475_RS18715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL475_RS18730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL475_RS18735	COG0575	Belongs to the CDS family
AL475_RS18740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL475_RS18745	COG0750	zinc metalloprotease
AL475_RS18755	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL475_RS18760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL475_RS18765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL475_RS18780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL475_RS18785	COG0587	DNA-directed DNA polymerase activity
AL475_RS18790	COG0825	malonyl-CoA metabolic process
AL475_RS18795	COG0037	tRNA processing
AL475_RS18805	COG0347	Belongs to the P(II) protein family
AL475_RS18810	COG3021	interspecies interaction between organisms
AL475_RS18820	COG0741	lytic transglycosylase activity
AL475_RS18820	COG1388	LysM domain
AL475_RS18825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL475_RS18830	COG2226	methyltransferase
AL475_RS18835	COG0328	RNA-DNA hybrid ribonuclease activity
AL475_RS18840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL475_RS18850	COG1960	acyl-CoA dehydrogenase activity
AL475_RS18855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL475_RS18860	COG0121	glutamine amidotransferase
AL475_RS18865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL475_RS18870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL475_RS18875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL475_RS18880	COG1187	pseudouridine synthase activity
AL475_RS18915	COG2608	mercury ion transmembrane transporter activity
AL475_RS18915	COG2217	Heavy metal translocating P-type atpase
AL475_RS18920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL475_RS18940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL475_RS18945	COG2194	sulfuric ester hydrolase activity
AL475_RS19035	COG4695	Portal protein
AL475_RS19065	COG2747	anti-sigma28 factor FlgM
AL475_RS19075	COG0835	chemotaxis
AL475_RS19075	COG0784	Response regulator, receiver
AL475_RS19080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL475_RS19085	COG1815	bacterial-type flagellum-dependent cell motility
AL475_RS19105	COG4787	bacterial-type flagellum-dependent cell motility
AL475_RS19115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL475_RS19120	COG1706	bacterial-type flagellum-dependent cell motility
AL475_RS19125	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL475_RS19125	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL475_RS19145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL475_RS19245	COG0193	aminoacyl-tRNA hydrolase activity
AL475_RS19250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL475_RS19260	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL475_RS19265	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL475_RS19270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL475_RS19275	COG2890	protein-(glutamine-N5) methyltransferase activity
AL475_RS19285	COG2912	Transglutaminase-like superfamily
AL475_RS19290	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL475_RS19295	COG0737	Belongs to the 5'-nucleotidase family
AL475_RS19305	COG2233	PERMEase
AL475_RS19325	COG1393	Belongs to the ArsC family
AL475_RS19330	COG4783	chaperone-mediated protein folding
AL475_RS19350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL475_RS19355	COG2716	regulation of RNA biosynthetic process
AL475_RS19365	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL475_RS19375	COG1876	peptidase activity
AL475_RS19385	COG1393	Belongs to the ArsC family
AL475_RS19395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL475_RS19405	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL475_RS19425	COG2837	iron assimilation
AL475_RS19435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL475_RS19440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL475_RS19445	COG1334	flagellar protein FlaG
AL475_RS19450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL475_RS19460	COG1516	flagellar protein fliS
AL475_RS19480	COG1677	Flagellar hook-basal body complex protein FliE
AL475_RS19490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL475_RS19540	COG1987	bacterial-type flagellum assembly
AL475_RS19555	COG2840	Smr protein MutS2
AL475_RS19560	COG2890	protein-(glutamine-N5) methyltransferase activity
AL475_RS19565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL475_RS19570	COG0583	DNA-binding transcription factor activity
AL475_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS19580	COG2860	membrane
AL475_RS19585	COG3101	peptidyl-lysine hydroxylation
AL475_RS19600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL475_RS19600	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL475_RS19605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL475_RS19610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL475_RS19615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL475_RS19620	COG0735	belongs to the Fur family
AL475_RS19630	COG0583	DNA-binding transcription factor activity
AL475_RS19635	COG1380	Effector of murein hydrolase LrgA
AL475_RS19640	COG1346	cytolysis
AL475_RS19655	COG0596	Alpha beta hydrolase
AL475_RS19660	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL475_RS19665	COG0033	Phosphoglucomutase
AL475_RS19675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL475_RS19690	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL475_RS19705	COG0567	Dehydrogenase, E1 component
AL475_RS19710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL475_RS19725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL475_RS19730	COG1121	(ABC) transporter
AL475_RS19735	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL475_RS19750	COG1918	ferrous iron import across plasma membrane
AL475_RS19770	COG0018	arginyl-trna synthetase
AL475_RS19775	COG3102	Protein conserved in bacteria
AL475_RS19785	COG2062	phosphohistidine phosphatase, SixA
AL475_RS19815	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL475_RS19820	COG0784	Response regulator, receiver
AL475_RS19820	COG2198	Histidine kinase
AL475_RS19820	COG0643	Histidine kinase
AL475_RS19825	COG2201	protein-glutamate methylesterase activity
AL475_RS19830	COG1192	Involved in chromosome partitioning
AL475_RS19840	COG0835	chemotaxis
AL475_RS19850	COG4133	protoheme IX ABC transporter activity
AL475_RS19855	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL475_RS19860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL475_RS19865	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL475_RS19870	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL475_RS19875	COG1138	Cytochrome C-type biogenesis protein
AL475_RS19880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL475_RS19895	COG2853	Lipoprotein
AL475_RS19915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL475_RS19920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL475_RS19925	COG3384	dioxygenase
AL475_RS19950	COG0667	Aldo Keto reductase
AL475_RS19965	COG0583	DNA-binding transcription factor activity
AL475_RS19970	COG2159	amidohydrolase
AL475_RS19975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL475_RS20015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL475_RS20030	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL475_RS20040	COG1448	Aminotransferase
AL475_RS20055	COG3083	sulfuric ester hydrolase activity
AL475_RS20060	COG3082	Protein of unknown function (DUF1414)
AL475_RS20065	COG3081	Nucleoid-associated protein
AL475_RS20075	COG1757	Na H antiporter
AL475_RS20080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL475_RS20085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL475_RS20090	COG2095	MarC family integral membrane protein
AL475_RS20095	COG1012	belongs to the aldehyde dehydrogenase family
AL475_RS20095	COG1454	alcohol dehydrogenase
AL475_RS20105	COG0659	secondary active sulfate transmembrane transporter activity
AL475_RS20115	COG1530	ribonuclease E activity
AL475_RS20120	COG0564	pseudouridine synthase activity
AL475_RS20125	COG0424	maF-like protein
AL475_RS20130	COG1399	metal-binding, possibly nucleic acid-binding protein
AL475_RS20135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL475_RS20140	COG0416	fatty acid biosynthetic process
AL475_RS20145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL475_RS20165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL475_RS20170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL475_RS20175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL475_RS20180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL475_RS20185	COG0470	DNA polymerase III
AL475_RS20190	COG0084	hydrolase, TatD family'
AL475_RS20195	COG1263	PTS System
AL475_RS20195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL475_RS20195	COG2190	(PTS) system
AL475_RS20205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL475_RS20205	COG1263	PTS System
AL475_RS20220	COG0733	neurotransmitter:sodium symporter activity
AL475_RS20235	COG4667	esterase of the alpha-beta hydrolase superfamily
AL475_RS20245	COG1940	carbohydrate kinase activity
AL475_RS20250	COG0784	Response regulator, receiver
AL475_RS20250	COG0835	chemotaxis
AL475_RS20255	COG0587	DNA-directed DNA polymerase activity
AL475_RS20270	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS20275	COG0616	signal peptide processing
AL475_RS20305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL475_RS20310	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL475_RS20315	COG0436	Aminotransferase
AL475_RS20320	COG1169	isochorismate synthase
AL475_RS20325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL475_RS20330	COG0596	Alpha beta hydrolase
AL475_RS20335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL475_RS20355	COG2855	membrane
AL475_RS20360	COG0477	Major facilitator Superfamily
AL475_RS20380	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AL475_RS20385	COG0741	lytic transglycosylase activity
AL475_RS20385	COG1388	LysM domain
AL475_RS20405	COG1815	bacterial-type flagellum-dependent cell motility
AL475_RS20410	COG1558	bacterial-type flagellum-dependent cell motility
AL475_RS20415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL475_RS20420	COG1749	Flagellar hook protein flgE
AL475_RS20430	COG4786	Flagellar basal body rod
AL475_RS20435	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL475_RS20440	COG1706	bacterial-type flagellum-dependent cell motility
AL475_RS20450	COG4786	Flagellar basal body rod
AL475_RS20450	COG1256	bacterial-type flagellum assembly
AL475_RS20500	COG0702	epimerase
AL475_RS20505	COG3015	lipoprotein NlpE involved in copper resistance
AL475_RS20515	COG1360	Flagellar Motor Protein
AL475_RS20520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL475_RS20525	COG1191	sigma factor activity
AL475_RS20530	COG1580	Controls the rotational direction of flagella during chemotaxis
AL475_RS20550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL475_RS20555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL475_RS20570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL475_RS20600	COG2885	chlorophyll binding
AL475_RS20645	COG1522	sequence-specific DNA binding
AL475_RS20650	COG1946	Acyl-CoA thioesterase
AL475_RS20655	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL475_RS20670	COG2203	Gaf domain
AL475_RS20670	COG2199	diguanylate cyclase activity
AL475_RS20695	COG0431	NADPH-dependent FMN reductase
AL475_RS20700	COG0697	spore germination
AL475_RS20710	COG1278	Cold shock
AL475_RS20745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL475_RS20750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL475_RS20755	COG1881	PFAM PEBP family protein
AL475_RS20760	COG2207	Transcriptional regulator
AL475_RS20790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL475_RS20795	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_RS20810	COG0642	Histidine kinase
AL475_RS20820	COG0671	phosphoesterase, PA-phosphatase related
AL475_RS20830	COG0513	Belongs to the DEAD box helicase family
AL475_RS20835	COG1368	sulfuric ester hydrolase activity
AL475_RS20840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL475_RS20845	COG2194	sulfuric ester hydrolase activity
AL475_RS20870	COG4566	intracellular signal transduction
AL475_RS20895	COG2863	cytochrome
AL475_RS20900	COG3258	Cytochrome c
AL475_RS20915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_RS20920	COG1271	oxidase subunit
AL475_RS20925	COG1294	oxidase, subunit
AL475_RS20965	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL475_RS20970	COG2814	Major facilitator Superfamily
AL475_RS20980	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL475_RS20985	COG1169	isochorismate synthase
AL475_RS20990	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS20995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL475_RS21000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL475_RS21000	COG2226	methyltransferase
AL475_RS21000	COG3433	isochorismatase activity
AL475_RS21015	COG4592	Periplasmic binding protein
AL475_RS21020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_RS21025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_RS21030	COG1629	transport
AL475_RS21030	COG4774	siderophore transport
AL475_RS21040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL475_RS21045	COG1120	ATPase activity
AL475_RS21055	COG1609	Transcriptional regulator
AL475_RS21060	COG2723	6-phospho-beta-galactosidase activity
AL475_RS21065	COG1741	Belongs to the pirin family
AL475_RS21070	COG0352	thiamine-phosphate diphosphorylase activity
AL475_RS21080	COG0351	phosphomethylpyrimidine kinase
AL475_RS21085	COG4172	Belongs to the ABC transporter superfamily
AL475_RS21090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_RS21095	COG0601	transmembrane transport
AL475_RS21100	COG0747	negative chemotaxis
AL475_RS21110	COG1538	Outer membrane efflux protein
AL475_RS21115	COG1566	PFAM secretion protein HlyD family protein
AL475_RS21120	COG2814	Major facilitator Superfamily
AL475_RS21125	COG2207	Transcriptional regulator
AL475_RS21125	COG3708	Transcriptional regulator
AL475_RS21135	COG0745	RESPONSE REGULATOR receiver
AL475_RS21145	COG1263	PTS System
AL475_RS21145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL475_RS21155	COG1621	beta-fructofuranosidase activity
AL475_RS21160	COG2202	Pas domain
AL475_RS21160	COG2199	diguanylate cyclase activity
AL475_RS21160	COG2200	EAL domain
AL475_RS21170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_RS21185	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS21220	COG2986	histidine ammonia-lyase
AL475_RS21225	COG1216	Glycosyl transferase, family 2
AL475_RS21245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL475_RS21250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL475_RS21285	COG0601	transmembrane transport
AL475_RS21290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_RS21295	COG0444	Belongs to the ABC transporter superfamily
AL475_RS21310	COG0435	Glutathione S-transferase
AL475_RS21315	COG3174	membrane
AL475_RS21320	COG0857	belongs to the CobB CobQ family
AL475_RS21320	COG0280	phosphate acetyltransferase
AL475_RS21325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL475_RS21330	COG3092	negative regulation of chromosome organization
AL475_RS21340	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL475_RS21350	COG3706	GGDEF domain
AL475_RS21360	COG2165	general secretion pathway protein
AL475_RS21365	COG0653	protein targeting
AL475_RS21370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL475_RS21375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL475_RS21380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL475_RS21390	COG0243	molybdopterin cofactor binding
AL475_RS21395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL475_RS21395	COG1648	precorrin-2 dehydrogenase activity
AL475_RS21410	COG1116	anion transmembrane transporter activity
AL475_RS21410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL475_RS21415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL475_RS21420	COG1116	anion transmembrane transporter activity
AL475_RS21425	COG2146	nitrite reductase [NAD(P)H] activity
AL475_RS21425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL475_RS21435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL475_RS21440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL475_RS21445	COG0156	8-amino-7-oxononanoate synthase activity
AL475_RS21450	COG2226	methyltransferase
AL475_RS21455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL475_RS21460	COG0501	Belongs to the peptidase M48B family
AL475_RS21470	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_RS21485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL475_RS21505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL475_RS21510	COG2915	High frequency lysogenization protein hflD homolog
AL475_RS21515	COG0482	sulfurtransferase activity
AL475_RS21520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_RS21525	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL475_RS21530	COG1757	Na H antiporter
AL475_RS21540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL475_RS21545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL475_RS21550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL475_RS21555	COG0131	Imidazoleglycerol-phosphate dehydratase
AL475_RS21555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL475_RS21560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL475_RS21565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL475_RS21575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL475_RS21575	COG0140	phosphoribosyl-ATP diphosphatase activity
AL475_RS21580	COG1187	pseudouridine synthase activity
AL475_RS21590	COG1278	Cold shock
AL475_RS21595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL475_RS21600	COG0542	response to heat
AL475_RS21605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL475_RS21610	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL475_RS21615	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL475_RS21635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL475_RS21645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL475_RS21650	COG0297	glycogen (starch) synthase activity
AL475_RS21670	COG3070	regulator of competence-specific genes
AL475_RS21675	COG1609	Transcriptional regulator
AL475_RS21680	COG3381	protein complex oligomerization
AL475_RS21685	COG0745	RESPONSE REGULATOR receiver
AL475_RS21690	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL475_RS21695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL475_RS21700	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL475_RS21705	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL475_RS21710	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL475_RS21715	COG0189	ligase activity
AL475_RS21725	COG0189	ligase activity
AL475_RS21725	COG4067	protein conserved in archaea
AL475_RS21730	COG0500	methyltransferase
AL475_RS21735	COG4106	trans-aconitate 2-methyltransferase activity
AL475_RS21750	COG1435	thymidine kinase activity
AL475_RS21755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL475_RS21760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL475_RS21780	COG2116	formate transmembrane transporter activity
AL475_RS21785	COG0390	transport system, permease component
AL475_RS21790	COG4459	periplasmic nitrate reductase
AL475_RS21795	COG3005	denitrification pathway
AL475_RS21800	COG0243	molybdopterin cofactor binding
AL475_RS21820	COG1227	inorganic diphosphatase activity
AL475_RS21835	COG4172	Belongs to the ABC transporter superfamily
AL475_RS21845	COG4171	peptide transport system, permease
AL475_RS21850	COG4168	peptide transport system, permease
AL475_RS21860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL475_RS21865	COG1842	Phage shock protein A
AL475_RS21880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_RS21895	COG0519	Catalyzes the synthesis of GMP from XMP
AL475_RS21910	COG4232	protein-disulfide reductase activity
AL475_RS21925	COG0626	cystathionine gamma-synthase activity
AL475_RS21935	COG0733	neurotransmitter:sodium symporter activity
AL475_RS21955	COG0564	pseudouridine synthase activity
AL475_RS21965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL475_RS21970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL475_RS21975	COG4136	ATPase activity
AL475_RS21980	COG4135	transport system, permease component
AL475_RS21985	COG4134	Bacterial extracellular solute-binding protein
AL475_RS21995	COG3313	Fe-S protein
AL475_RS22005	COG0842	Transport permease protein
AL475_RS22010	COG1131	(ABC) transporter
AL475_RS22020	COG0814	amino acid
AL475_RS22040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL475_RS22050	COG1278	Cold shock
AL475_RS22060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL475_RS22070	COG3119	arylsulfatase activity
AL475_RS22075	COG0641	radical SAM
AL475_RS22080	COG0714	Associated with various cellular activities
AL475_RS22115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL475_RS22135	COG1061	Type III restriction enzyme res subunit
AL475_RS22145	COG2814	Major facilitator Superfamily
AL475_RS22155	COG0702	epimerase
AL475_RS22160	COG0534	Mate efflux family protein
AL475_RS22165	COG4181	ATPase activity
AL475_RS22180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL475_RS22230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_RS22245	COG3265	gluconokinase activity
AL475_RS22250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL475_RS22280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL475_RS22285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL475_RS22300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL475_RS22325	COG2989	Protein conserved in bacteria
AL475_RS22330	COG3108	Peptidase M15
AL475_RS22335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL475_RS22350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_RS22370	COG2197	response regulator
AL475_RS22375	COG1846	Transcriptional regulator
AL475_RS22380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL475_RS22385	COG0840	transmembrane signaling receptor activity
AL475_RS22390	COG2176	DNA-directed DNA polymerase activity
AL475_RS22395	COG0516	GMP reductase activity
AL475_RS22395	COG0517	IMP dehydrogenase activity
AL475_RS22405	COG1448	Aminotransferase
AL475_RS22420	COG0017	Asparaginyl-tRNA synthetase
AL475_RS22425	COG0840	transmembrane signaling receptor activity
AL475_RS22430	COG0720	synthase
AL475_RS22440	COG1136	(ABC) transporter
AL475_RS22440	COG0577	efflux transmembrane transporter activity
AL475_RS22445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_RS22450	COG1760	l-serine dehydratase
AL475_RS22455	COG0814	amino acid
AL475_RS22460	COG0494	nUDIX hydrolase
AL475_RS22475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL475_RS22490	COG3106	COG3106 Predicted ATPase
AL475_RS22505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL475_RS22525	COG0471	metal ion transport
AL475_RS22530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_RS22530	COG4191	Histidine kinase
AL475_RS22540	COG0583	DNA-binding transcription factor activity
AL475_RS22545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL475_RS22550	COG0778	Nitroreductase
AL475_RS22555	COG2991	Protein conserved in bacteria
AL475_RS22565	COG3250	beta-galactosidase activity
AL475_RS22575	COG1129	ABC transporter
AL475_RS22610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL475_RS22610	COG2169	Transcriptional regulator
AL475_RS22620	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL475_RS22625	COG0372	Belongs to the citrate synthase family
AL475_RS22630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL475_RS22635	COG2828	Protein conserved in bacteria
AL475_RS22650	COG1566	PFAM secretion protein HlyD family protein
AL475_RS22655	COG2814	Major facilitator Superfamily
AL475_RS22670	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL475_RS22675	COG2200	EAL domain
AL475_RS22685	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL475_RS22695	COG0625	glutathione transferase activity
AL475_RS22715	COG2731	YhcH YjgK YiaL family protein
AL475_RS22725	COG0584	glycerophosphoryl diester phosphodiesterase
AL475_RS22730	COG1349	DNA-binding transcription factor activity
AL475_RS22735	COG3842	ATPase activity
AL475_RS22740	COG0395	ABC-type sugar transport system, permease component
AL475_RS22750	COG1653	transport
AL475_RS22755	COG0039	L-malate dehydrogenase activity
AL475_RS22760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL475_RS22765	COG3040	lipid binding
AL475_RS22775	COG0811	peptide transport
AL475_RS22780	COG0811	peptide transport
AL475_RS22785	COG0848	biopolymer transport protein
AL475_RS22805	COG4667	esterase of the alpha-beta hydrolase superfamily
AL475_RS22810	COG1793	dna ligase
AL475_RS22825	COG0307	riboflavin synthase, alpha
AL475_RS22835	COG3001	Fructosamine kinase
AL475_RS22845	COG0791	NLP P60 protein
AL475_RS22850	COG0840	transmembrane signaling receptor activity
AL475_RS22860	COG3148	PFAM DTW domain containing protein
AL475_RS22865	COG1940	carbohydrate kinase activity
AL475_RS22875	COG0303	'Molybdopterin
AL475_RS22880	COG0746	molybdenum cofactor guanylyltransferase activity
AL475_RS22885	COG3842	ATPase activity
AL475_RS22890	COG4662	Binding-protein-dependent transport system inner membrane component
AL475_RS22900	COG2204	response regulator
AL475_RS22905	COG3852	Histidine kinase
AL475_RS22920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL475_RS22940	COG3381	protein complex oligomerization