locus-tag	class	description
AL536_RS10365	COG0840	transmembrane signaling receptor activity
AL536_RS16075	COG0513	Belongs to the DEAD box helicase family
AL536_RS16845	COG0583	DNA-binding transcription factor activity
AL536_RS18230	COG2226	methyltransferase
AL536_RS22705	COG0724	RNA recognition motif
AL536_RS22710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL536_RS22715	COG1522	sequence-specific DNA binding
AL536_RS22720	COG2610	gluconate transmembrane transporter activity
AL536_RS22725	COG3622	Belongs to the hyi family
AL536_RS22730	COG0235	Class ii aldolase
AL536_RS22735	COG3395	kinase activity
AL536_RS22740	COG2084	Dehydrogenase
AL536_RS22745	COG1349	DNA-binding transcription factor activity
AL536_RS22760	COG0583	DNA-binding transcription factor activity
AL536_RS22765	COG2910	NAD(P)H-binding
AL536_RS22780	COG1335	isochorismatase
AL536_RS22800	COG2329	Antibiotic biosynthesis monooxygenase
AL536_RS22805	COG3304	Inner membrane component domain
AL536_RS22820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS22855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL536_RS22865	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL536_RS22870	COG0426	domain, Protein
AL536_RS22870	COG1773	rubredoxin
AL536_RS22885	COG0367	asparagine synthase
AL536_RS22925	COG2176	DNA-directed DNA polymerase activity
AL536_RS22945	COG0443	Heat shock 70 kDa protein
AL536_RS22950	COG0095	Lipoate-protein ligase
AL536_RS22965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL536_RS22970	COG1473	amidohydrolase
AL536_RS22985	COG3722	fumarate hydratase activity
AL536_RS22995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL536_RS22995	COG2213	PTS system mannitol-specific
AL536_RS23000	COG0739	heme binding
AL536_RS23015	COG0363	glucosamine-6-phosphate deaminase activity
AL536_RS23040	COG0402	S-adenosylhomocysteine deaminase activity
AL536_RS23045	COG2259	Doxx family
AL536_RS23050	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL536_RS23055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL536_RS23065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL536_RS23070	COG1301	dicarboxylic acid transport
AL536_RS23090	COG2169	Transcriptional regulator
AL536_RS23090	COG1917	Cupin 2, conserved barrel domain protein
AL536_RS23125	COG1764	response to oxidative stress
AL536_RS23130	COG1846	Transcriptional regulator
AL536_RS23135	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL536_RS23155	COG1280	lysine exporter protein (LysE YggA)
AL536_RS23165	COG1902	pentaerythritol trinitrate reductase activity
AL536_RS23170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL536_RS23180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL536_RS23215	COG0109	protoheme IX farnesyltransferase activity
AL536_RS23230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL536_RS23240	COG3447	MASE1 domain protein
AL536_RS23240	COG5001	Diguanylate cyclase
AL536_RS23240	COG5002	protein histidine kinase activity
AL536_RS23260	COG2169	Transcriptional regulator
AL536_RS23280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS23285	COG0697	spore germination
AL536_RS23290	COG3477	response to acidic pH
AL536_RS23295	COG0477	Major facilitator Superfamily
AL536_RS23300	COG0625	glutathione transferase activity
AL536_RS23310	COG1942	4-Oxalocrotonate Tautomerase
AL536_RS23325	COG0583	DNA-binding transcription factor activity
AL536_RS23345	COG3152	Membrane
AL536_RS23355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL536_RS23365	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL536_RS23380	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL536_RS23395	COG1620	l-lactate permease
AL536_RS23405	COG0583	DNA-binding transcription factor activity
AL536_RS23410	COG4172	Belongs to the ABC transporter superfamily
AL536_RS23420	COG1067	ATP-dependent peptidase activity
AL536_RS23425	COG0840	transmembrane signaling receptor activity
AL536_RS23430	COG2211	Major facilitator Superfamily
AL536_RS23435	COG0668	transmembrane transport
AL536_RS23440	COG0569	domain protein
AL536_RS23445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL536_RS23455	COG3123	guanosine phosphorylase activity
AL536_RS23460	COG1741	Belongs to the pirin family
AL536_RS23470	COG5001	Diguanylate cyclase
AL536_RS23495	COG3706	GGDEF domain
AL536_RS23515	COG3706	GGDEF domain
AL536_RS23525	COG1846	Transcriptional regulator
AL536_RS23530	COG2315	Protein conserved in bacteria
AL536_RS23535	COG0835	chemotaxis
AL536_RS23535	COG0784	Response regulator, receiver
AL536_RS23540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL536_RS23555	COG1942	4-Oxalocrotonate Tautomerase
AL536_RS23575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL536_RS23595	COG1522	sequence-specific DNA binding
AL536_RS23605	COG0393	Putative heavy-metal-binding
AL536_RS23610	COG0823	Involved in the tonB-independent uptake of proteins
AL536_RS23615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL536_RS23620	COG0534	Mate efflux family protein
AL536_RS23630	COG1653	transport
AL536_RS23635	COG3842	ATPase activity
AL536_RS23640	COG0395	ABC-type sugar transport system, permease component
AL536_RS23645	COG1175	transmembrane transport
AL536_RS23665	COG0800	Aldolase
AL536_RS23670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL536_RS23685	COG1917	Cupin 2, conserved barrel domain protein
AL536_RS23695	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS23700	COG1414	Transcriptional regulator
AL536_RS23725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL536_RS23735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS23775	COG3842	ATPase activity
AL536_RS23785	COG1175	transmembrane transport
AL536_RS23790	COG3833	ABC-type maltose transport systems, permease component
AL536_RS23815	COG1349	DNA-binding transcription factor activity
AL536_RS23835	COG2354	Protein conserved in bacteria
AL536_RS23840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL536_RS23845	COG0418	dihydroorotase activity
AL536_RS23855	COG0633	Ferredoxin
AL536_RS23855	COG3217	Mosc domain protein beta barrel domain protein
AL536_RS23885	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL536_RS23890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL536_RS23900	COG0848	biopolymer transport protein
AL536_RS23905	COG0811	peptide transport
AL536_RS23910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL536_RS23915	COG3721	Heme iron utilization protein
AL536_RS23920	COG0748	coenzyme F420 binding
AL536_RS23930	COG0531	amino acid
AL536_RS23935	COG1522	sequence-specific DNA binding
AL536_RS23960	COG1151	hydroxylamine reductase activity
AL536_RS23965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL536_RS23970	COG2200	EAL domain
AL536_RS23995	COG0784	Response regulator, receiver
AL536_RS23995	COG2205	protein histidine kinase activity
AL536_RS23995	COG5002	protein histidine kinase activity
AL536_RS24000	COG3300	MHYT domain
AL536_RS24000	COG5001	Diguanylate cyclase
AL536_RS24015	COG1765	OsmC-like protein
AL536_RS24050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL536_RS24060	COG1022	Amp-dependent synthetase and ligase
AL536_RS24085	COG0642	Histidine kinase
AL536_RS24095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL536_RS24100	COG3186	Phenylalanine-4-hydroxylase
AL536_RS24105	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL536_RS24110	COG0534	Mate efflux family protein
AL536_RS24120	COG0861	Integral membrane protein TerC family
AL536_RS24130	COG0456	acetyltransferase
AL536_RS24135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL536_RS24140	COG0662	Cupin 2, conserved barrel domain protein
AL536_RS24145	COG0527	aspartate kinase activity
AL536_RS24150	COG0561	phosphatase activity
AL536_RS24160	COG0583	DNA-binding transcription factor activity
AL536_RS24170	COG3437	response regulator, receiver
AL536_RS24170	COG0784	Response regulator, receiver
AL536_RS24180	COG0113	porphobilinogen synthase activity
AL536_RS24190	COG0459	protein refolding
AL536_RS24195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL536_RS24200	COG2239	Acts as a magnesium transporter
AL536_RS24220	COG2113	Glycine betaine
AL536_RS24225	COG4176	ABC-type proline glycine betaine transport system permease component
AL536_RS24230	COG4175	Glycine betaine
AL536_RS24240	COG1166	arginine decarboxylase activity
AL536_RS24250	COG1522	sequence-specific DNA binding
AL536_RS24265	COG0765	amino acid transport
AL536_RS24275	COG1686	Belongs to the peptidase S11 family
AL536_RS24290	COG1566	PFAM secretion protein HlyD family protein
AL536_RS24300	COG3338	carbonate dehydratase activity
AL536_RS24335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL536_RS24345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL536_RS24355	COG1280	lysine exporter protein (LysE YggA)
AL536_RS24360	COG0513	Belongs to the DEAD box helicase family
AL536_RS24375	COG0840	transmembrane signaling receptor activity
AL536_RS24390	COG2985	domain, Protein
AL536_RS24400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL536_RS24420	COG1280	lysine exporter protein (LysE YggA)
AL536_RS24465	COG3122	Protein conserved in bacteria
AL536_RS24485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL536_RS24485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL536_RS24490	COG0509	glycine decarboxylation via glycine cleavage system
AL536_RS24505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL536_RS24515	COG3706	GGDEF domain
AL536_RS24520	COG5001	Diguanylate cyclase
AL536_RS24525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL536_RS24540	COG0546	phosphoglycolate phosphatase activity
AL536_RS24565	COG0484	heat shock protein binding
AL536_RS24575	COG5001	Diguanylate cyclase
AL536_RS24575	COG1716	ATPase activity
AL536_RS24580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL536_RS24590	COG4181	ATPase activity
AL536_RS24595	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL536_RS24605	COG1984	allophanate hydrolase subunit 2
AL536_RS24615	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL536_RS24620	COG5002	protein histidine kinase activity
AL536_RS24620	COG5001	Diguanylate cyclase
AL536_RS24620	COG3447	MASE1 domain protein
AL536_RS24625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL536_RS24630	COG0840	transmembrane signaling receptor activity
AL536_RS24635	COG0814	amino acid
AL536_RS24640	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL536_RS24645	COG0513	Belongs to the DEAD box helicase family
AL536_RS24650	COG1309	transcriptional regulator
AL536_RS24660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL536_RS24680	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL536_RS24710	COG0840	transmembrane signaling receptor activity
AL536_RS24720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL536_RS24730	COG0463	Glycosyl transferase, family 2
AL536_RS24740	COG0583	DNA-binding transcription factor activity
AL536_RS24745	COG0697	spore germination
AL536_RS24750	COG2207	Transcriptional regulator
AL536_RS24750	COG1917	Cupin 2, conserved barrel domain protein
AL536_RS24775	COG0330	HflC and HflK could
AL536_RS24785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL536_RS24800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL536_RS24805	COG0583	DNA-binding transcription factor activity
AL536_RS24810	COG3781	membrane
AL536_RS24820	COG1271	oxidase subunit
AL536_RS24825	COG1294	oxidase, subunit
AL536_RS24830	COG0800	Aldolase
AL536_RS24835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL536_RS24840	COG1904	glucuronate isomerase
AL536_RS24845	COG0246	Mannitol dehydrogenase
AL536_RS24860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL536_RS24870	COG2186	Transcriptional regulator
AL536_RS24880	COG2390	Transcriptional regulator
AL536_RS24890	COG1070	Carbohydrate kinase
AL536_RS24900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL536_RS24915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL536_RS24945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL536_RS24980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL536_RS24990	COG2116	formate transmembrane transporter activity
AL536_RS24995	COG1648	precorrin-2 dehydrogenase activity
AL536_RS24995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL536_RS25025	COG3118	belongs to the thioredoxin family
AL536_RS25030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL536_RS25045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL536_RS25055	COG1596	polysaccharide export
AL536_RS25080	COG0438	transferase activity, transferring glycosyl groups
AL536_RS25085	COG0297	glycogen (starch) synthase activity
AL536_RS25085	COG0438	transferase activity, transferring glycosyl groups
AL536_RS25100	COG0247	lactate metabolic process
AL536_RS25105	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AL536_RS25110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL536_RS25115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL536_RS25120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL536_RS25170	COG4386	tail sheath protein
AL536_RS25210	COG4695	Portal protein
AL536_RS25390	COG4974	Belongs to the 'phage' integrase family
AL536_RS25405	COG3132	Protein of unknown function, DUF480
AL536_RS25410	COG2827	Endonuclease containing a URI domain
AL536_RS25420	COG1879	ABC-type sugar transport system periplasmic component
AL536_RS25425	COG0784	Response regulator, receiver
AL536_RS25425	COG5002	protein histidine kinase activity
AL536_RS25445	COG1492	cobalamin metabolic process
AL536_RS25450	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL536_RS25455	COG4149	molybdate abc transporter
AL536_RS25460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL536_RS25475	COG1289	transmembrane transporter activity
AL536_RS25515	COG0210	DNA helicase
AL536_RS25520	COG1335	isochorismatase
AL536_RS25525	COG1803	Methylglyoxal synthase
AL536_RS25530	COG1879	ABC-type sugar transport system periplasmic component
AL536_RS25535	COG0784	Response regulator, receiver
AL536_RS25535	COG2198	Histidine kinase
AL536_RS25535	COG2205	protein histidine kinase activity
AL536_RS25540	COG0469	pyruvate kinase activity
AL536_RS25545	COG2271	Major facilitator Superfamily
AL536_RS25570	COG1979	alcohol dehydrogenase
AL536_RS25575	COG2207	Transcriptional regulator
AL536_RS25590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL536_RS25615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL536_RS25620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL536_RS25630	COG0183	Belongs to the thiolase family
AL536_RS25670	COG0243	molybdopterin cofactor binding
AL536_RS25685	COG3850	Histidine kinase
AL536_RS25690	COG2197	response regulator
AL536_RS25695	COG3069	C4-dicarboxylate transmembrane transporter activity
AL536_RS25710	COG2814	Major facilitator Superfamily
AL536_RS25715	COG0840	transmembrane signaling receptor activity
AL536_RS25720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL536_RS25725	COG0545	Peptidyl-prolyl cis-trans isomerase
AL536_RS25740	COG0840	transmembrane signaling receptor activity
AL536_RS25745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL536_RS25760	COG2897	thiosulfate sulfurtransferase activity
AL536_RS25765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL536_RS25775	COG0302	gtp cyclohydrolase
AL536_RS25780	COG0531	amino acid
AL536_RS25790	COG4303	Ethanolamine ammonia lyase large subunit
AL536_RS25795	COG2207	Transcriptional regulator
AL536_RS25800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL536_RS25800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL536_RS25805	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL536_RS25810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL536_RS25820	COG1011	Hydrolase
AL536_RS25825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL536_RS25835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL536_RS25840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL536_RS25845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL536_RS25855	COG3842	ATPase activity
AL536_RS25875	COG2866	Carboxypeptidase
AL536_RS25900	COG4166	transmembrane transport
AL536_RS25905	COG4174	ABC transporter (Permease)
AL536_RS25910	COG4239	(ABC) transporter, permease
AL536_RS25915	COG4172	Belongs to the ABC transporter superfamily
AL536_RS25920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL536_RS25940	COG2203	Gaf domain
AL536_RS25940	COG3706	GGDEF domain
AL536_RS25940	COG4251	negative regulation of phosphorylation
AL536_RS25940	COG5001	Diguanylate cyclase
AL536_RS25950	COG3706	GGDEF domain
AL536_RS25965	COG2501	S4 domain
AL536_RS26005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL536_RS26030	COG1979	alcohol dehydrogenase
AL536_RS26035	COG2207	Transcriptional regulator
AL536_RS26055	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL536_RS26065	COG0488	(ABC) transporter
AL536_RS26075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL536_RS26085	COG2814	Major facilitator Superfamily
AL536_RS26105	COG3710	Transcriptional regulator
AL536_RS26135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS26150	COG2233	PERMEase
AL536_RS26170	COG1953	Uracil, thiamine, allantoin
AL536_RS26180	COG0765	amino acid transport
AL536_RS26185	COG0765	amino acid transport
AL536_RS26215	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL536_RS26235	COG0402	S-adenosylhomocysteine deaminase activity
AL536_RS26240	COG2351	hydroxyisourate hydrolase activity
AL536_RS26270	COG1079	Belongs to the binding-protein-dependent transport system permease family
AL536_RS26275	COG4603	Belongs to the binding-protein-dependent transport system permease family
AL536_RS26280	COG3845	ABC transporter
AL536_RS26285	COG1309	transcriptional regulator
AL536_RS26320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL536_RS26325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL536_RS26335	COG0745	RESPONSE REGULATOR receiver
AL536_RS26350	COG3140	Belongs to the UPF0181 family
AL536_RS26355	COG0023	Translation Initiation Factor
AL536_RS26370	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL536_RS26380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL536_RS26380	COG1042	CoA-binding domain protein
AL536_RS26380	COG0045	succinate-CoA ligase (ADP-forming) activity
AL536_RS26385	COG0583	DNA-binding transcription factor activity
AL536_RS26390	COG4771	TonB-dependent receptor
AL536_RS26390	COG1629	transport
AL536_RS26410	COG2050	protein possibly involved in aromatic compounds catabolism
AL536_RS26415	COG0501	Belongs to the peptidase M48B family
AL536_RS26420	COG2824	Alkylphosphonate utilization operon protein PhnA
AL536_RS26430	COG0861	Integral membrane protein TerC family
AL536_RS26435	COG0737	Belongs to the 5'-nucleotidase family
AL536_RS26440	COG3593	DNA synthesis involved in DNA repair
AL536_RS26450	COG0583	DNA-binding transcription factor activity
AL536_RS26455	COG2116	formate transmembrane transporter activity
AL536_RS26460	COG2353	YceI-like domain
AL536_RS26465	COG3038	cytochrome b561
AL536_RS26490	COG5001	Diguanylate cyclase
AL536_RS26500	COG0243	molybdopterin cofactor binding
AL536_RS26505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL536_RS26510	COG0543	2 iron, 2 sulfur cluster binding
AL536_RS26510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL536_RS26515	COG2205	protein histidine kinase activity
AL536_RS26515	COG5002	protein histidine kinase activity
AL536_RS26515	COG0784	Response regulator, receiver
AL536_RS26520	COG3437	response regulator, receiver
AL536_RS26530	COG2207	Transcriptional regulator
AL536_RS26535	COG0582	viral genome integration into host DNA
AL536_RS26550	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL536_RS26555	COG2200	EAL domain
AL536_RS26555	COG2202	Pas domain
AL536_RS26555	COG2199	diguanylate cyclase activity
AL536_RS26575	COG2200	EAL domain
AL536_RS26620	COG2181	nitrate reductase activity
AL536_RS26625	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AL536_RS26630	COG1140	nitrate reductase beta subunit
AL536_RS26635	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL536_RS26640	COG2223	nitrite transmembrane transporter activity
AL536_RS26645	COG3850	Histidine kinase
AL536_RS26650	COG2197	response regulator
AL536_RS26655	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AL536_RS26665	COG0840	transmembrane signaling receptor activity
AL536_RS26665	COG3290	protein histidine kinase activity
AL536_RS26715	COG1518	maintenance of DNA repeat elements
AL536_RS26730	COG1609	Transcriptional regulator
AL536_RS26740	COG2017	converts alpha-aldose to the beta-anomer
AL536_RS26745	COG3459	Glycosyltransferase 36 associated
AL536_RS26755	COG2723	6-phospho-beta-galactosidase activity
AL536_RS26760	COG0395	ABC-type sugar transport system, permease component
AL536_RS26765	COG1175	transmembrane transport
AL536_RS26775	COG1609	Transcriptional regulator
AL536_RS26780	COG0840	transmembrane signaling receptor activity
AL536_RS26790	COG0534	Mate efflux family protein
AL536_RS26805	COG2003	Belongs to the UPF0758 family
AL536_RS26840	COG0328	RNA-DNA hybrid ribonuclease activity
AL536_RS26905	COG0523	cobalamin synthesis protein
AL536_RS26920	COG0156	8-amino-7-oxononanoate synthase activity
AL536_RS26925	COG0784	Response regulator, receiver
AL536_RS26925	COG2205	protein histidine kinase activity
AL536_RS26930	COG0419	ATPase involved in DNA repair
AL536_RS26940	COG1609	Transcriptional regulator
AL536_RS26945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL536_RS26945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL536_RS26950	COG1105	Belongs to the carbohydrate kinase PfkB family
AL536_RS26955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS26955	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL536_RS26955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS26960	COG0189	ligase activity
AL536_RS26960	COG4067	protein conserved in archaea
AL536_RS26970	COG0602	queuosine metabolic process
AL536_RS26975	COG1328	CTP reductase activity
AL536_RS27040	COG1280	lysine exporter protein (LysE YggA)
AL536_RS27045	COG0745	RESPONSE REGULATOR receiver
AL536_RS27055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL536_RS27065	COG0583	DNA-binding transcription factor activity
AL536_RS27080	COG1309	transcriptional regulator
AL536_RS27085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL536_RS27115	COG1335	isochorismatase
AL536_RS27120	COG4977	sequence-specific DNA binding
AL536_RS27125	COG0456	acetyltransferase
AL536_RS27135	COG1280	lysine exporter protein (LysE YggA)
AL536_RS27140	COG0494	nUDIX hydrolase
AL536_RS27150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL536_RS27180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL536_RS27200	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS27210	COG0454	-acetyltransferase
AL536_RS27270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL536_RS27275	COG0789	Transcriptional regulator
AL536_RS27330	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS27340	COG4628	conserved protein (DUF2132)
AL536_RS27380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL536_RS27385	COG0513	Belongs to the DEAD box helicase family
AL536_RS27400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL536_RS27410	COG0583	DNA-binding transcription factor activity
AL536_RS27415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL536_RS27425	COG3710	Transcriptional regulator
AL536_RS27430	COG4232	protein-disulfide reductase activity
AL536_RS27435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL536_RS27440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL536_RS27450	COG1252	NADH dehydrogenase
AL536_RS27460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS27465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS27475	COG2207	Transcriptional regulator
AL536_RS27480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS27480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS27480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL536_RS27495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS27510	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL536_RS27515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AL536_RS27520	COG1349	DNA-binding transcription factor activity
AL536_RS27525	COG0110	maltose O-acetyltransferase activity
AL536_RS27530	COG3706	GGDEF domain
AL536_RS27540	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL536_RS27550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL536_RS27560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL536_RS27570	COG0747	negative chemotaxis
AL536_RS27575	COG4172	Belongs to the ABC transporter superfamily
AL536_RS27585	COG3437	response regulator, receiver
AL536_RS27590	COG2205	protein histidine kinase activity
AL536_RS27590	COG2198	Histidine kinase
AL536_RS27590	COG0784	Response regulator, receiver
AL536_RS27600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL536_RS27625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL536_RS27640	COG2423	ornithine cyclodeaminase activity
AL536_RS27650	COG4145	pantothenate transmembrane transporter activity
AL536_RS27655	COG0583	DNA-binding transcription factor activity
AL536_RS27660	COG0435	Glutathione S-transferase
AL536_RS27665	COG0400	carboxylic ester hydrolase activity
AL536_RS27670	COG1280	lysine exporter protein (LysE YggA)
AL536_RS27685	COG1473	amidohydrolase
AL536_RS27705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL536_RS27710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL536_RS27715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL536_RS27725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL536_RS27740	COG2721	sulfolactate sulfo-lyase activity
AL536_RS27795	COG0625	glutathione transferase activity
AL536_RS27805	COG1472	Belongs to the glycosyl hydrolase 3 family
AL536_RS27815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL536_RS27825	COG0573	inorganic phosphate transmembrane transporter activity
AL536_RS27830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL536_RS27850	COG1464	Belongs to the NlpA lipoprotein family
AL536_RS27855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL536_RS27855	COG0512	Glutamine amidotransferase of anthranilate synthase
AL536_RS27875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL536_RS27890	COG0653	protein targeting
AL536_RS27895	COG2814	Major facilitator Superfamily
AL536_RS27905	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS27915	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS27925	COG1024	Enoyl-CoA hydratase
AL536_RS27930	COG1024	Enoyl-CoA hydratase
AL536_RS27935	COG1960	acyl-CoA dehydrogenase activity
AL536_RS27945	COG0183	Belongs to the thiolase family
AL536_RS27955	COG1960	acyl-CoA dehydrogenase activity
AL536_RS27960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL536_RS27965	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL536_RS27985	COG0450	alkyl hydroperoxide reductase
AL536_RS27990	COG3634	alkyl hydroperoxide reductase activity
AL536_RS28020	COG1609	Transcriptional regulator
AL536_RS28020	COG2207	Transcriptional regulator
AL536_RS28025	COG1454	alcohol dehydrogenase
AL536_RS28030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL536_RS28080	COG1051	belongs to the nudix hydrolase family
AL536_RS28085	COG0784	Response regulator, receiver
AL536_RS28085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL536_RS28125	COG0582	viral genome integration into host DNA
AL536_RS28145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL536_RS28160	COG2207	Transcriptional regulator
AL536_RS28160	COG1609	Transcriptional regulator
AL536_RS28165	COG4604	ABC transporter, ATP-binding protein
AL536_RS28170	COG4605	iron ion homeostasis
AL536_RS28175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL536_RS28200	COG5380	lipid catabolic process
AL536_RS28205	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL536_RS28215	COG1522	sequence-specific DNA binding
AL536_RS28235	COG2814	Major facilitator Superfamily
AL536_RS28245	COG0840	transmembrane signaling receptor activity
AL536_RS28260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL536_RS28265	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL536_RS28270	COG3279	Response regulator of the LytR AlgR family
AL536_RS28275	COG3275	phosphorelay sensor kinase activity
AL536_RS28280	COG4989	oxidoreductase activity
AL536_RS28295	COG0366	Alpha amylase catalytic
AL536_RS28300	COG3227	Zinc metalloprotease (Elastase)
AL536_RS28305	COG3047	cAMP biosynthetic process
AL536_RS28310	COG0071	Belongs to the small heat shock protein (HSP20) family
AL536_RS28325	COG0251	oxidation-reduction process
AL536_RS28360	COG4916	TIR domain
AL536_RS28385	COG1132	(ABC) transporter
AL536_RS28390	COG1132	(ABC) transporter
AL536_RS28400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL536_RS28405	COG2246	polysaccharide biosynthetic process
AL536_RS28420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL536_RS28430	COG0242	peptide deformylase activity
AL536_RS28440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS28445	COG2084	Dehydrogenase
AL536_RS28455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL536_RS28460	COG0583	DNA-binding transcription factor activity
AL536_RS28510	COG1063	alcohol dehydrogenase
AL536_RS28515	COG0156	8-amino-7-oxononanoate synthase activity
AL536_RS28520	COG1012	belongs to the aldehyde dehydrogenase family
AL536_RS28525	COG3284	Transcriptional regulator
AL536_RS28535	COG0346	lactoylglutathione lyase activity
AL536_RS28555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL536_RS28565	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL536_RS28570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL536_RS28575	COG0363	glucosamine-6-phosphate deaminase activity
AL536_RS28580	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL536_RS28595	COG0583	DNA-binding transcription factor activity
AL536_RS28610	COG0646	methionine synthase
AL536_RS28610	COG1410	methionine synthase
AL536_RS28615	COG0531	amino acid
AL536_RS28630	COG1473	amidohydrolase
AL536_RS28635	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL536_RS28640	COG1929	Belongs to the glycerate kinase type-1 family
AL536_RS28645	COG2610	gluconate transmembrane transporter activity
AL536_RS28650	COG3835	regulator
AL536_RS28655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL536_RS28660	COG4533	DNA binding
AL536_RS28675	COG0840	transmembrane signaling receptor activity
AL536_RS28730	COG4964	Belongs to the GSP D family
AL536_RS28770	COG0798	PFAM Bile acid sodium symporter
AL536_RS28780	COG4974	Belongs to the 'phage' integrase family
AL536_RS28800	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL536_RS28805	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL536_RS28810	COG1129	ABC transporter
AL536_RS28825	COG0604	alcohol dehydrogenase
AL536_RS28825	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS28825	COG3321	synthase
AL536_RS28835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS28840	COG4974	Belongs to the 'phage' integrase family
AL536_RS28845	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AL536_RS28860	COG1482	cell wall glycoprotein biosynthetic process
AL536_RS28865	COG0840	transmembrane signaling receptor activity
AL536_RS28870	COG4580	involved in the transport of maltose and maltodextrins
AL536_RS28875	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AL536_RS28880	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AL536_RS28890	COG1609	Transcriptional regulator
AL536_RS28900	COG2942	2-epimerase
AL536_RS28905	COG5578	integral membrane protein
AL536_RS28910	COG0395	ABC-type sugar transport system, permease component
AL536_RS28915	COG1175	transmembrane transport
AL536_RS29045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL536_RS29050	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL536_RS29050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL536_RS29060	COG0745	RESPONSE REGULATOR receiver
AL536_RS29080	COG3036	rescue of stalled ribosome
AL536_RS29085	COG1278	Cold shock
AL536_RS29090	COG4681	YaeQ
AL536_RS29100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL536_RS29100	COG1017	nitric oxide dioxygenase activity
AL536_RS29105	COG3604	Transcriptional regulator
AL536_RS29115	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL536_RS29120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL536_RS29130	COG0366	Alpha amylase catalytic
AL536_RS29150	COG0714	Associated with various cellular activities
AL536_RS29170	COG2304	oxidoreductase activity
AL536_RS29185	COG3706	GGDEF domain
AL536_RS29195	COG0784	Response regulator, receiver
AL536_RS29195	COG5002	protein histidine kinase activity
AL536_RS29195	COG2205	protein histidine kinase activity
AL536_RS29210	COG3724	N-succinylarginine dihydrolase activity
AL536_RS29215	COG1012	belongs to the aldehyde dehydrogenase family
AL536_RS29240	COG4948	Mandelate Racemase Muconate Lactonizing
AL536_RS29265	COG0583	DNA-binding transcription factor activity
AL536_RS29290	COG3171	Protein conserved in bacteria
AL536_RS29295	COG0589	response to stress
AL536_RS29305	COG3530	Putative quorum-sensing-regulated virulence factor
AL536_RS29315	COG0579	oxidoreductase
AL536_RS29330	COG2204	response regulator
AL536_RS29340	COG1929	Belongs to the glycerate kinase type-1 family
AL536_RS29345	COG0383	alpha-mannosidase activity
AL536_RS29350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL536_RS29350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS29350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL536_RS29355	COG2188	Transcriptional regulator
AL536_RS29380	COG5001	Diguanylate cyclase
AL536_RS29380	COG3300	MHYT domain
AL536_RS29385	COG2271	Major facilitator Superfamily
AL536_RS29390	COG0584	glycerophosphoryl diester phosphodiesterase
AL536_RS29395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL536_RS29400	COG0583	DNA-binding transcription factor activity
AL536_RS29410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL536_RS29415	COG1879	ABC-type sugar transport system periplasmic component
AL536_RS29420	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL536_RS29425	COG1129	ABC transporter
AL536_RS29430	COG1869	D-ribose catabolic process
AL536_RS29470	COG3829	transcription factor binding
AL536_RS29540	COG1280	lysine exporter protein (LysE YggA)
AL536_RS29545	COG1846	Transcriptional regulator
AL536_RS29560	COG0564	pseudouridine synthase activity
AL536_RS29565	COG1309	transcriptional regulator
AL536_RS29570	COG2130	NADP-dependent
AL536_RS29585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL536_RS29615	COG3842	ATPase activity
AL536_RS29625	COG2200	EAL domain
AL536_RS29630	COG0656	L-ascorbic acid biosynthetic process
AL536_RS29635	COG1902	pentaerythritol trinitrate reductase activity
AL536_RS29640	COG0583	DNA-binding transcription factor activity
AL536_RS29645	COG2814	Major facilitator Superfamily
AL536_RS29680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL536_RS29690	COG4702	Belongs to the UPF0303 family
AL536_RS29695	COG0673	inositol 2-dehydrogenase activity
AL536_RS29700	COG1349	DNA-binding transcription factor activity
AL536_RS29705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL536_RS29725	COG3240	lipase activity
AL536_RS29730	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS29735	COG0583	DNA-binding transcription factor activity
AL536_RS29745	COG1120	ATPase activity
AL536_RS29750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL536_RS29755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL536_RS29760	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL536_RS29765	COG4774	siderophore transport
AL536_RS29790	COG0840	transmembrane signaling receptor activity
AL536_RS29795	COG3384	dioxygenase
AL536_RS29800	COG0583	DNA-binding transcription factor activity
AL536_RS29810	COG1342	Belongs to the UPF0251 family
AL536_RS29815	COG0778	Nitroreductase
AL536_RS29820	COG0583	DNA-binding transcription factor activity
AL536_RS29830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL536_RS29835	COG0697	spore germination
AL536_RS29850	COG2814	Major facilitator Superfamily
AL536_RS29855	COG0583	DNA-binding transcription factor activity
AL536_RS29860	COG3300	MHYT domain
AL536_RS29860	COG5001	Diguanylate cyclase
AL536_RS29865	COG0739	heme binding
AL536_RS29880	COG0659	secondary active sulfate transmembrane transporter activity
AL536_RS29885	COG3314	Sporulation integral membrane protein YlbJ
AL536_RS29895	COG2199	diguanylate cyclase activity
AL536_RS29900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL536_RS29905	COG0581	inorganic phosphate transmembrane transporter activity
AL536_RS29910	COG0573	inorganic phosphate transmembrane transporter activity
AL536_RS29915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL536_RS29920	COG0840	transmembrane signaling receptor activity
AL536_RS29925	COG0513	Belongs to the DEAD box helicase family
AL536_RS29935	COG1388	LysM domain
AL536_RS29935	COG1376	ErfK ybiS ycfS ynhG family protein
AL536_RS29940	COG0415	Belongs to the DNA photolyase family
AL536_RS29950	COG3272	Protein of unknown function (DUF1722)
AL536_RS29955	COG0813	purine-nucleoside phosphorylase activity
AL536_RS29980	COG1566	PFAM secretion protein HlyD family protein
AL536_RS30015	COG0786	glutamate:sodium symporter activity
AL536_RS30030	COG1999	signal sequence binding
AL536_RS30040	COG1162	GTPase activity
AL536_RS30045	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL536_RS30060	COG4580	involved in the transport of maltose and maltodextrins
AL536_RS30080	COG1132	(ABC) transporter
AL536_RS30090	COG0671	phosphoesterase, PA-phosphatase related
AL536_RS30100	COG3383	formate dehydrogenase (NAD+) activity
AL536_RS30105	COG0010	Belongs to the arginase family
AL536_RS30115	COG0840	transmembrane signaling receptor activity
AL536_RS30125	COG1131	(ABC) transporter
AL536_RS30130	COG2188	Transcriptional regulator
AL536_RS30140	COG3033	Beta-eliminating lyase
AL536_RS30145	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL536_RS30150	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL536_RS30160	COG0471	metal ion transport
AL536_RS30185	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AL536_RS30205	COG3501	Rhs element vgr protein
AL536_RS30215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL536_RS30220	COG1640	4-alpha-glucanotransferase
AL536_RS30225	COG0058	SHG alpha-glucan phosphorylase activity
AL536_RS30230	COG2909	trisaccharide binding
AL536_RS30245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL536_RS30250	COG1845	cytochrome c oxidase, subunit III
AL536_RS30255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL536_RS30260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL536_RS30275	COG2084	Dehydrogenase
AL536_RS30290	COG0217	transcriptional regulatory protein
AL536_RS30325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL536_RS30330	COG1444	tRNA N-acetyltransferase activity
AL536_RS30345	COG2198	Histidine kinase
AL536_RS30345	COG0643	Histidine kinase
AL536_RS30355	COG0835	chemotaxis
AL536_RS30360	COG0840	transmembrane signaling receptor activity
AL536_RS30365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL536_RS30375	COG2201	protein-glutamate methylesterase activity
AL536_RS30390	COG0745	RESPONSE REGULATOR receiver
AL536_RS30430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL536_RS30445	COG0204	Acyl-transferase
AL536_RS30450	COG0251	oxidation-reduction process
AL536_RS30460	COG0540	Belongs to the ATCase OTCase family
AL536_RS30465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL536_RS30470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL536_RS30480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL536_RS30490	COG0564	pseudouridine synthase activity
AL536_RS30495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL536_RS30500	COG0525	valine-tRNA ligase activity
AL536_RS30510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL536_RS30515	COG0795	lipopolysaccharide-transporting ATPase activity
AL536_RS30520	COG0795	lipopolysaccharide-transporting ATPase activity
AL536_RS30560	COG2203	Gaf domain
AL536_RS30560	COG2200	EAL domain
AL536_RS30560	COG2199	diguanylate cyclase activity
AL536_RS30570	COG3437	response regulator, receiver
AL536_RS30615	COG0066	3-isopropylmalate dehydratase activity
AL536_RS30620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL536_RS30625	COG0473	3-isopropylmalate dehydrogenase activity
AL536_RS30650	COG0583	DNA-binding transcription factor activity
AL536_RS30655	COG1022	Amp-dependent synthetase and ligase
AL536_RS30660	COG0028	Belongs to the TPP enzyme family
AL536_RS30665	COG0440	acetolactate synthase activity
AL536_RS30670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL536_RS30680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL536_RS30690	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL536_RS30695	COG3079	Belongs to the UPF0149 family
AL536_RS30700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL536_RS30705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL536_RS30725	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL536_RS30735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL536_RS30740	COG1595	DNA-templated transcription, initiation
AL536_RS30755	COG3086	response to oxidative stress
AL536_RS30760	COG0481	GTPase activity
AL536_RS30770	COG0571	ribonuclease III activity
AL536_RS30775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL536_RS30780	COG1381	Involved in DNA repair and RecF pathway recombination
AL536_RS30785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL536_RS30790	COG0736	holo-[acyl-carrier-protein] synthase activity
AL536_RS30800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL536_RS30805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL536_RS30810	COG3956	TIGRFAM MazG family protein
AL536_RS30815	COG0504	CTP synthase activity
AL536_RS30820	COG0148	phosphopyruvate hydratase activity
AL536_RS30825	COG0617	tRNA 3'-terminal CCA addition
AL536_RS30830	COG3409	Peptidoglycan-binding domain 1 protein
AL536_RS30830	COG3267	Type II secretory pathway component ExeA
AL536_RS30840	COG4991	sh3 domain protein
AL536_RS30845	COG0306	phosphate transporter
AL536_RS30850	COG1392	Phosphate transport regulator
AL536_RS30855	COG3025	triphosphatase activity
AL536_RS30860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL536_RS30870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL536_RS30875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL536_RS30875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL536_RS30880	COG1538	Outer membrane efflux protein
AL536_RS30885	COG0494	nUDIX hydrolase
AL536_RS30890	COG3151	Protein conserved in bacteria
AL536_RS30900	COG3150	esterase
AL536_RS30910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL536_RS30920	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL536_RS30935	COG1459	type II secretion system
AL536_RS30940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL536_RS30965	COG4974	Belongs to the 'phage' integrase family
AL536_RS30970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL536_RS30975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL536_RS30980	COG2186	Transcriptional regulator
AL536_RS30985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL536_RS30990	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL536_RS30995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL536_RS31010	COG0288	reversible hydration of carbon dioxide
AL536_RS31015	COG1131	(ABC) transporter
AL536_RS31020	COG0842	Transport permease protein
AL536_RS31025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL536_RS31030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL536_RS31035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL536_RS31045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL536_RS31050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL536_RS31055	COG1489	DNA binding
AL536_RS31060	COG1643	Atp-dependent helicase
AL536_RS31065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL536_RS31070	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL536_RS31075	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL536_RS31080	COG3112	Uncharacterised protein family (UPF0231)
AL536_RS31085	COG0347	Belongs to the P(II) protein family
AL536_RS31090	COG0004	ammonium transporteR
AL536_RS31095	COG1840	ABC-type Fe3 transport system, periplasmic component
AL536_RS31105	COG3842	ATPase activity
AL536_RS31110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL536_RS31125	COG2971	BadF BadG BcrA BcrD
AL536_RS31135	COG4608	Belongs to the ABC transporter superfamily
AL536_RS31140	COG0444	Belongs to the ABC transporter superfamily
AL536_RS31145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL536_RS31155	COG0747	negative chemotaxis
AL536_RS31160	COG2205	protein histidine kinase activity
AL536_RS31160	COG0784	Response regulator, receiver
AL536_RS31170	COG0628	permease
AL536_RS31175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL536_RS31180	COG0316	Belongs to the HesB IscA family
AL536_RS31195	COG0739	heme binding
AL536_RS31200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL536_RS31210	COG2239	Acts as a magnesium transporter
AL536_RS31215	COG2027	D-alanyl-D-alanine carboxypeptidase
AL536_RS31220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL536_RS31225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL536_RS31230	COG1534	Rna-binding protein
AL536_RS31235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL536_RS31240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL536_RS31245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL536_RS31250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL536_RS31255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL536_RS31270	COG0779	Required for maturation of 30S ribosomal subunits
AL536_RS31275	COG0195	Participates in both transcription termination and antitermination
AL536_RS31285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL536_RS31290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL536_RS31295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL536_RS31315	COG0534	Mate efflux family protein
AL536_RS31320	COG0826	peptidase U32
AL536_RS31325	COG0826	peptidase U32
AL536_RS31335	COG3154	lipid carrier protein
AL536_RS31340	COG3153	acetyltransferase
AL536_RS31365	COG0513	Belongs to the DEAD box helicase family
AL536_RS31390	COG2204	response regulator
AL536_RS31400	COG0667	Aldo Keto reductase
AL536_RS31415	COG0494	nUDIX hydrolase
AL536_RS31425	COG0730	response to heat
AL536_RS31435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL536_RS31440	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL536_RS31445	COG0583	DNA-binding transcription factor activity
AL536_RS31450	COG0640	Transcriptional regulator
AL536_RS31455	COG0268	Binds directly to 16S ribosomal RNA
AL536_RS31460	COG0728	peptidoglycan biosynthetic process
AL536_RS31465	COG0196	riboflavin kinase activity
AL536_RS31470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL536_RS31475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL536_RS31480	COG1047	Peptidyl-prolyl cis-trans
AL536_RS31485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL536_RS31490	COG1966	Carbon starvation protein
AL536_RS31505	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL536_RS31510	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL536_RS31520	COG3279	Response regulator of the LytR AlgR family
AL536_RS31525	COG3275	phosphorelay sensor kinase activity
AL536_RS31530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL536_RS31535	COG1605	Chorismate mutase
AL536_RS31535	COG0287	Prephenate dehydrogenase
AL536_RS31545	COG0488	(ABC) transporter
AL536_RS31555	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL536_RS31560	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL536_RS31565	COG5001	Diguanylate cyclase
AL536_RS31570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL536_RS31575	COG0077	Prephenate dehydratase
AL536_RS31575	COG1605	Chorismate mutase
AL536_RS31580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL536_RS31585	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL536_RS31590	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL536_RS31595	COG0564	pseudouridine synthase activity
AL536_RS31605	COG0542	response to heat
AL536_RS31615	COG0590	tRNA wobble adenosine to inosine editing
AL536_RS31620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL536_RS31705	COG0271	Belongs to the BolA IbaG family
AL536_RS31710	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL536_RS31715	COG1805	sodium ion transport
AL536_RS31725	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL536_RS31730	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL536_RS31735	COG2871	sodium ion transport
AL536_RS31740	COG1477	protein flavinylation
AL536_RS31755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL536_RS31765	COG2203	Gaf domain
AL536_RS31765	COG3706	GGDEF domain
AL536_RS31765	COG4251	negative regulation of phosphorylation
AL536_RS31765	COG5001	Diguanylate cyclase
AL536_RS31770	COG0733	neurotransmitter:sodium symporter activity
AL536_RS31780	COG0189	ligase activity
AL536_RS31785	COG4067	protein conserved in archaea
AL536_RS31785	COG0189	ligase activity
AL536_RS31790	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL536_RS31795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS31800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL536_RS31810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL536_RS31820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL536_RS31825	COG2252	PERMEase
AL536_RS31830	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL536_RS31835	COG1073	alpha beta
AL536_RS31845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL536_RS31850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL536_RS31855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL536_RS31860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL536_RS31860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL536_RS31875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL536_RS31880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL536_RS31885	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL536_RS31890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL536_RS31900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL536_RS31905	COG0024	Methionine aminopeptidase
AL536_RS31910	COG0052	Belongs to the universal ribosomal protein uS2 family
AL536_RS31915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL536_RS31930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL536_RS31935	COG0575	Belongs to the CDS family
AL536_RS31940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL536_RS31945	COG0750	zinc metalloprotease
AL536_RS31955	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL536_RS31960	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL536_RS31965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL536_RS31980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL536_RS31985	COG0587	DNA-directed DNA polymerase activity
AL536_RS31990	COG0825	malonyl-CoA metabolic process
AL536_RS31995	COG0037	tRNA processing
AL536_RS32005	COG0347	Belongs to the P(II) protein family
AL536_RS32010	COG3021	interspecies interaction between organisms
AL536_RS32020	COG0741	lytic transglycosylase activity
AL536_RS32020	COG1388	LysM domain
AL536_RS32025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL536_RS32030	COG2226	methyltransferase
AL536_RS32035	COG0328	RNA-DNA hybrid ribonuclease activity
AL536_RS32040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL536_RS32050	COG1960	acyl-CoA dehydrogenase activity
AL536_RS32055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL536_RS32060	COG0121	glutamine amidotransferase
AL536_RS32065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL536_RS32070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL536_RS32075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL536_RS32080	COG1187	pseudouridine synthase activity
AL536_RS32085	COG2840	Smr protein MutS2
AL536_RS32115	COG2217	Heavy metal translocating P-type atpase
AL536_RS32115	COG2608	mercury ion transmembrane transporter activity
AL536_RS32120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL536_RS32140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL536_RS32145	COG2194	sulfuric ester hydrolase activity
AL536_RS32180	COG2747	anti-sigma28 factor FlgM
AL536_RS32190	COG0784	Response regulator, receiver
AL536_RS32190	COG0835	chemotaxis
AL536_RS32195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL536_RS32200	COG1815	bacterial-type flagellum-dependent cell motility
AL536_RS32220	COG4787	bacterial-type flagellum-dependent cell motility
AL536_RS32230	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL536_RS32235	COG1706	bacterial-type flagellum-dependent cell motility
AL536_RS32240	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL536_RS32240	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL536_RS32260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL536_RS32360	COG0193	aminoacyl-tRNA hydrolase activity
AL536_RS32365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL536_RS32375	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL536_RS32380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL536_RS32385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL536_RS32390	COG2890	protein-(glutamine-N5) methyltransferase activity
AL536_RS32400	COG2912	Transglutaminase-like superfamily
AL536_RS32405	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL536_RS32410	COG0737	Belongs to the 5'-nucleotidase family
AL536_RS32420	COG2233	PERMEase
AL536_RS32440	COG1393	Belongs to the ArsC family
AL536_RS32445	COG4783	chaperone-mediated protein folding
AL536_RS32465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL536_RS32470	COG2716	regulation of RNA biosynthetic process
AL536_RS32480	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL536_RS32490	COG1876	peptidase activity
AL536_RS32500	COG1393	Belongs to the ArsC family
AL536_RS32510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL536_RS32520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL536_RS32540	COG2837	iron assimilation
AL536_RS32550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL536_RS32555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL536_RS32560	COG1334	flagellar protein FlaG
AL536_RS32565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL536_RS32575	COG1516	flagellar protein fliS
AL536_RS32595	COG1677	Flagellar hook-basal body complex protein FliE
AL536_RS32605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL536_RS32655	COG1987	bacterial-type flagellum assembly
AL536_RS32670	COG2840	Smr protein MutS2
AL536_RS32675	COG2890	protein-(glutamine-N5) methyltransferase activity
AL536_RS32680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL536_RS32685	COG0583	DNA-binding transcription factor activity
AL536_RS32690	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS32695	COG2860	membrane
AL536_RS32700	COG3101	peptidyl-lysine hydroxylation
AL536_RS32720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL536_RS32725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL536_RS32730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL536_RS32735	COG0735	belongs to the Fur family
AL536_RS32745	COG0583	DNA-binding transcription factor activity
AL536_RS32750	COG1380	Effector of murein hydrolase LrgA
AL536_RS32755	COG1346	cytolysis
AL536_RS32770	COG0596	Alpha beta hydrolase
AL536_RS32775	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL536_RS32780	COG0033	Phosphoglucomutase
AL536_RS32790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL536_RS32805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL536_RS32820	COG0567	Dehydrogenase, E1 component
AL536_RS32825	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL536_RS32840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL536_RS32845	COG1121	(ABC) transporter
AL536_RS32850	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL536_RS32860	COG1918	ferrous iron import across plasma membrane
AL536_RS32880	COG0018	arginyl-trna synthetase
AL536_RS32885	COG3102	Protein conserved in bacteria
AL536_RS32895	COG2062	phosphohistidine phosphatase, SixA
AL536_RS32925	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL536_RS32930	COG2198	Histidine kinase
AL536_RS32930	COG0784	Response regulator, receiver
AL536_RS32930	COG0643	Histidine kinase
AL536_RS32935	COG2201	protein-glutamate methylesterase activity
AL536_RS32940	COG1192	Involved in chromosome partitioning
AL536_RS32950	COG0835	chemotaxis
AL536_RS32960	COG4133	protoheme IX ABC transporter activity
AL536_RS32965	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL536_RS32970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL536_RS32975	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL536_RS32980	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL536_RS32985	COG1138	Cytochrome C-type biogenesis protein
AL536_RS32990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL536_RS33005	COG2853	Lipoprotein
AL536_RS33025	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL536_RS33030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL536_RS33035	COG3384	dioxygenase
AL536_RS33060	COG0667	Aldo Keto reductase
AL536_RS33075	COG0583	DNA-binding transcription factor activity
AL536_RS33080	COG2159	amidohydrolase
AL536_RS33085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL536_RS33125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL536_RS33140	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL536_RS33150	COG1448	Aminotransferase
AL536_RS33165	COG3083	sulfuric ester hydrolase activity
AL536_RS33170	COG3082	Protein of unknown function (DUF1414)
AL536_RS33175	COG3081	Nucleoid-associated protein
AL536_RS33185	COG1757	Na H antiporter
AL536_RS33190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL536_RS33195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL536_RS33200	COG2095	MarC family integral membrane protein
AL536_RS33205	COG1454	alcohol dehydrogenase
AL536_RS33205	COG1012	belongs to the aldehyde dehydrogenase family
AL536_RS33215	COG0659	secondary active sulfate transmembrane transporter activity
AL536_RS33225	COG1530	ribonuclease E activity
AL536_RS33230	COG0564	pseudouridine synthase activity
AL536_RS33235	COG0424	maF-like protein
AL536_RS33240	COG1399	metal-binding, possibly nucleic acid-binding protein
AL536_RS33245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL536_RS33250	COG0416	fatty acid biosynthetic process
AL536_RS33255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL536_RS33275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL536_RS33280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL536_RS33285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL536_RS33290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL536_RS33295	COG0470	DNA polymerase III
AL536_RS33300	COG0084	hydrolase, TatD family'
AL536_RS33305	COG1263	PTS System
AL536_RS33305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL536_RS33305	COG2190	(PTS) system
AL536_RS33315	COG1263	PTS System
AL536_RS33315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL536_RS33330	COG0733	neurotransmitter:sodium symporter activity
AL536_RS33345	COG4667	esterase of the alpha-beta hydrolase superfamily
AL536_RS33350	COG0469	pyruvate kinase activity
AL536_RS33355	COG1940	carbohydrate kinase activity
AL536_RS33360	COG0835	chemotaxis
AL536_RS33360	COG0784	Response regulator, receiver
AL536_RS33365	COG0587	DNA-directed DNA polymerase activity
AL536_RS33380	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS33385	COG0616	signal peptide processing
AL536_RS33435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL536_RS33440	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL536_RS33445	COG0436	Aminotransferase
AL536_RS33450	COG1169	isochorismate synthase
AL536_RS33455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL536_RS33460	COG0596	Alpha beta hydrolase
AL536_RS33465	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL536_RS33485	COG2855	membrane
AL536_RS33490	COG0477	Major facilitator Superfamily
AL536_RS33510	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AL536_RS33515	COG1388	LysM domain
AL536_RS33515	COG0741	lytic transglycosylase activity
AL536_RS33535	COG1815	bacterial-type flagellum-dependent cell motility
AL536_RS33540	COG1558	bacterial-type flagellum-dependent cell motility
AL536_RS33545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL536_RS33550	COG1749	Flagellar hook protein flgE
AL536_RS33560	COG4786	Flagellar basal body rod
AL536_RS33565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL536_RS33570	COG1706	bacterial-type flagellum-dependent cell motility
AL536_RS33580	COG4786	Flagellar basal body rod
AL536_RS33580	COG1256	bacterial-type flagellum assembly
AL536_RS33630	COG0702	epimerase
AL536_RS33635	COG3015	lipoprotein NlpE involved in copper resistance
AL536_RS33645	COG1360	Flagellar Motor Protein
AL536_RS33650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL536_RS33655	COG1191	sigma factor activity
AL536_RS33660	COG1580	Controls the rotational direction of flagella during chemotaxis
AL536_RS33680	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL536_RS33685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL536_RS33700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL536_RS33730	COG3047	cAMP biosynthetic process
AL536_RS33730	COG2885	chlorophyll binding
AL536_RS33775	COG1522	sequence-specific DNA binding
AL536_RS33780	COG1946	Acyl-CoA thioesterase
AL536_RS33785	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL536_RS33800	COG2203	Gaf domain
AL536_RS33800	COG2199	diguanylate cyclase activity
AL536_RS33905	COG2203	Gaf domain
AL536_RS33905	COG3706	GGDEF domain
AL536_RS33905	COG4251	negative regulation of phosphorylation
AL536_RS33905	COG5001	Diguanylate cyclase
AL536_RS33960	COG0431	NADPH-dependent FMN reductase
AL536_RS33965	COG0697	spore germination
AL536_RS33975	COG1278	Cold shock
AL536_RS34000	COG2207	Transcriptional regulator
AL536_RS34005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS34010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL536_RS34010	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL536_RS34015	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL536_RS34020	COG1881	PFAM PEBP family protein
AL536_RS34025	COG2207	Transcriptional regulator
AL536_RS34055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL536_RS34060	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL536_RS34075	COG0642	Histidine kinase
AL536_RS34085	COG0671	phosphoesterase, PA-phosphatase related
AL536_RS34095	COG0513	Belongs to the DEAD box helicase family
AL536_RS34100	COG1368	sulfuric ester hydrolase activity
AL536_RS34105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL536_RS34110	COG2194	sulfuric ester hydrolase activity
AL536_RS34130	COG4566	intracellular signal transduction
AL536_RS34155	COG2863	cytochrome
AL536_RS34160	COG3258	Cytochrome c
AL536_RS34175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL536_RS34180	COG1271	oxidase subunit
AL536_RS34185	COG1294	oxidase, subunit
AL536_RS34225	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL536_RS34230	COG2814	Major facilitator Superfamily
AL536_RS34240	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL536_RS34245	COG1169	isochorismate synthase
AL536_RS34250	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS34255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL536_RS34260	COG3433	isochorismatase activity
AL536_RS34260	COG2226	methyltransferase
AL536_RS34260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL536_RS34275	COG4592	Periplasmic binding protein
AL536_RS34280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL536_RS34285	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL536_RS34290	COG1629	transport
AL536_RS34290	COG4774	siderophore transport
AL536_RS34300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL536_RS34305	COG1120	ATPase activity
AL536_RS34315	COG1609	Transcriptional regulator
AL536_RS34320	COG2723	6-phospho-beta-galactosidase activity
AL536_RS34325	COG1741	Belongs to the pirin family
AL536_RS34330	COG0352	thiamine-phosphate diphosphorylase activity
AL536_RS34340	COG0351	phosphomethylpyrimidine kinase
AL536_RS34350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL536_RS34355	COG0601	transmembrane transport
AL536_RS34360	COG0747	negative chemotaxis
AL536_RS34370	COG1538	Outer membrane efflux protein
AL536_RS34375	COG1566	PFAM secretion protein HlyD family protein
AL536_RS34380	COG2814	Major facilitator Superfamily
AL536_RS34385	COG3708	Transcriptional regulator
AL536_RS34385	COG2207	Transcriptional regulator
AL536_RS34395	COG0745	RESPONSE REGULATOR receiver
AL536_RS34405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL536_RS34405	COG1263	PTS System
AL536_RS34415	COG1621	beta-fructofuranosidase activity
AL536_RS34420	COG2202	Pas domain
AL536_RS34420	COG2200	EAL domain
AL536_RS34420	COG2199	diguanylate cyclase activity
AL536_RS34430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL536_RS34445	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS34480	COG2986	histidine ammonia-lyase
AL536_RS34485	COG1216	Glycosyl transferase, family 2
AL536_RS34495	COG0318	PFAM AMP-dependent synthetase and ligase
AL536_RS34505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL536_RS34510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL536_RS34515	COG0318	PFAM AMP-dependent synthetase and ligase
AL536_RS34515	COG0204	Acyl-transferase
AL536_RS34545	COG0601	transmembrane transport
AL536_RS34550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL536_RS34555	COG0444	Belongs to the ABC transporter superfamily
AL536_RS34570	COG0435	Glutathione S-transferase
AL536_RS34575	COG3174	membrane
AL536_RS34580	COG0280	phosphate acetyltransferase
AL536_RS34580	COG0857	belongs to the CobB CobQ family
AL536_RS34585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL536_RS34590	COG3092	negative regulation of chromosome organization
AL536_RS34600	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL536_RS34610	COG3706	GGDEF domain
AL536_RS34625	COG0653	protein targeting
AL536_RS34630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL536_RS34635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL536_RS34640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL536_RS34650	COG0243	molybdopterin cofactor binding
AL536_RS34655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL536_RS34655	COG1648	precorrin-2 dehydrogenase activity
AL536_RS34670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL536_RS34670	COG1116	anion transmembrane transporter activity
AL536_RS34675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL536_RS34680	COG1116	anion transmembrane transporter activity
AL536_RS34685	COG2146	nitrite reductase [NAD(P)H] activity
AL536_RS34685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL536_RS34695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL536_RS34700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL536_RS34710	COG2226	methyltransferase
AL536_RS34715	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL536_RS34720	COG0501	Belongs to the peptidase M48B family
AL536_RS34730	COG1028	Short-chain dehydrogenase reductase Sdr
AL536_RS34745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL536_RS34765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL536_RS34770	COG2915	High frequency lysogenization protein hflD homolog
AL536_RS34775	COG0482	sulfurtransferase activity
AL536_RS34780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL536_RS34785	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL536_RS34790	COG1757	Na H antiporter
AL536_RS34800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL536_RS34805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL536_RS34810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL536_RS34815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL536_RS34815	COG0131	Imidazoleglycerol-phosphate dehydratase
AL536_RS34820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL536_RS34825	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL536_RS34835	COG0140	phosphoribosyl-ATP diphosphatase activity
AL536_RS34835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL536_RS34840	COG1187	pseudouridine synthase activity
AL536_RS34850	COG1278	Cold shock
AL536_RS34855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL536_RS34860	COG0542	response to heat
AL536_RS34865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL536_RS34870	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL536_RS34875	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL536_RS34895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL536_RS34905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL536_RS34910	COG0297	glycogen (starch) synthase activity
AL536_RS34930	COG3070	regulator of competence-specific genes
AL536_RS34935	COG1609	Transcriptional regulator
AL536_RS34940	COG3381	protein complex oligomerization
AL536_RS34945	COG0745	RESPONSE REGULATOR receiver
AL536_RS34950	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL536_RS34955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL536_RS34960	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL536_RS34965	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL536_RS34970	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL536_RS34975	COG0189	ligase activity
AL536_RS34985	COG4067	protein conserved in archaea
AL536_RS34985	COG0189	ligase activity
AL536_RS34990	COG0500	methyltransferase
AL536_RS34995	COG4106	trans-aconitate 2-methyltransferase activity
AL536_RS35010	COG1435	thymidine kinase activity
AL536_RS35020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL536_RS35040	COG2116	formate transmembrane transporter activity
AL536_RS35045	COG0390	transport system, permease component
AL536_RS35050	COG4459	periplasmic nitrate reductase
AL536_RS35055	COG3005	denitrification pathway
AL536_RS35060	COG0243	molybdopterin cofactor binding
AL536_RS35080	COG1227	inorganic diphosphatase activity
AL536_RS35095	COG4172	Belongs to the ABC transporter superfamily
AL536_RS35105	COG4171	peptide transport system, permease
AL536_RS35110	COG4168	peptide transport system, permease
AL536_RS35120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL536_RS35125	COG1842	Phage shock protein A
AL536_RS35140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL536_RS35155	COG0519	Catalyzes the synthesis of GMP from XMP
AL536_RS35185	COG0626	cystathionine gamma-synthase activity
AL536_RS35195	COG0733	neurotransmitter:sodium symporter activity
AL536_RS35215	COG0564	pseudouridine synthase activity
AL536_RS35225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL536_RS35230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL536_RS35235	COG4136	ATPase activity
AL536_RS35240	COG4135	transport system, permease component
AL536_RS35245	COG4134	Bacterial extracellular solute-binding protein
AL536_RS35255	COG3313	Fe-S protein
AL536_RS35265	COG0842	Transport permease protein
AL536_RS35270	COG1131	(ABC) transporter
AL536_RS35280	COG0814	amino acid
AL536_RS35300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL536_RS35310	COG1278	Cold shock
AL536_RS35320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL536_RS35330	COG3119	arylsulfatase activity
AL536_RS35335	COG0641	radical SAM
AL536_RS35340	COG0714	Associated with various cellular activities
AL536_RS35375	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL536_RS35380	COG2205	protein histidine kinase activity
AL536_RS35395	COG1061	Type III restriction enzyme res subunit
AL536_RS35405	COG2814	Major facilitator Superfamily
AL536_RS35415	COG0702	epimerase
AL536_RS35420	COG0534	Mate efflux family protein
AL536_RS35425	COG4181	ATPase activity
AL536_RS35440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL536_RS35490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL536_RS35505	COG3265	gluconokinase activity
AL536_RS35510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL536_RS35540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL536_RS35545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL536_RS35560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL536_RS35585	COG2989	Protein conserved in bacteria
AL536_RS35590	COG3108	Peptidase M15
AL536_RS35595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL536_RS35610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL536_RS35630	COG2197	response regulator
AL536_RS35635	COG1846	Transcriptional regulator
AL536_RS35640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL536_RS35645	COG0840	transmembrane signaling receptor activity
AL536_RS35650	COG2176	DNA-directed DNA polymerase activity
AL536_RS35655	COG0517	IMP dehydrogenase activity
AL536_RS35665	COG1448	Aminotransferase
AL536_RS35680	COG0017	Asparaginyl-tRNA synthetase
AL536_RS35685	COG0840	transmembrane signaling receptor activity
AL536_RS35690	COG0720	synthase
AL536_RS35700	COG1136	(ABC) transporter
AL536_RS35700	COG0577	efflux transmembrane transporter activity
AL536_RS35705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL536_RS35710	COG1760	l-serine dehydratase
AL536_RS35715	COG0814	amino acid
AL536_RS35720	COG0494	nUDIX hydrolase
AL536_RS35735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL536_RS35750	COG3106	COG3106 Predicted ATPase
AL536_RS35765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL536_RS35785	COG0471	metal ion transport
AL536_RS35790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL536_RS35790	COG4191	Histidine kinase
AL536_RS35800	COG0583	DNA-binding transcription factor activity
AL536_RS35805	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL536_RS35810	COG0778	Nitroreductase
AL536_RS35815	COG2991	Protein conserved in bacteria
AL536_RS35825	COG3250	beta-galactosidase activity
AL536_RS35835	COG1129	ABC transporter
AL536_RS35870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL536_RS35870	COG2169	Transcriptional regulator
AL536_RS35880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL536_RS35885	COG0372	Belongs to the citrate synthase family
AL536_RS35890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL536_RS35895	COG2828	Protein conserved in bacteria
AL536_RS35910	COG1566	PFAM secretion protein HlyD family protein
AL536_RS35915	COG2814	Major facilitator Superfamily
AL536_RS35930	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL536_RS35935	COG2200	EAL domain
AL536_RS35945	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL536_RS35955	COG0625	glutathione transferase activity
AL536_RS35975	COG2731	YhcH YjgK YiaL family protein
AL536_RS35980	COG0584	glycerophosphoryl diester phosphodiesterase
AL536_RS35985	COG1349	DNA-binding transcription factor activity
AL536_RS35990	COG3842	ATPase activity
AL536_RS35995	COG0395	ABC-type sugar transport system, permease component
AL536_RS36005	COG1653	transport
AL536_RS36010	COG0039	L-malate dehydrogenase activity
AL536_RS36015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL536_RS36020	COG3040	lipid binding
AL536_RS36030	COG0811	peptide transport
AL536_RS36035	COG0811	peptide transport
AL536_RS36040	COG0848	biopolymer transport protein
AL536_RS36060	COG4667	esterase of the alpha-beta hydrolase superfamily
AL536_RS36065	COG1793	dna ligase
AL536_RS36080	COG0307	riboflavin synthase, alpha
AL536_RS36090	COG3001	Fructosamine kinase
AL536_RS36100	COG0791	NLP P60 protein
AL536_RS36105	COG0840	transmembrane signaling receptor activity
AL536_RS36115	COG3148	PFAM DTW domain containing protein
AL536_RS36120	COG1940	carbohydrate kinase activity
AL536_RS36130	COG0303	'Molybdopterin
AL536_RS36135	COG0746	molybdenum cofactor guanylyltransferase activity
AL536_RS36140	COG3842	ATPase activity
AL536_RS36145	COG4662	Binding-protein-dependent transport system inner membrane component
AL536_RS36155	COG2204	response regulator
AL536_RS36160	COG3852	Histidine kinase
AL536_RS36175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL536_RS36195	COG3381	protein complex oligomerization
AL536_RS36205	COG3383	formate dehydrogenase (NAD+) activity
AL536_RS36205	COG0243	molybdopterin cofactor binding
AL536_RS36210	COG0437	4 iron, 4 sulfur cluster binding
AL536_RS36225	COG0004	ammonium transporteR
AL536_RS36230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL536_RS36235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL536_RS36245	COG1177	transmembrane transport
AL536_RS36255	COG3842	ATPase activity
AL536_RS36280	COG0589	response to stress
AL536_RS36285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL536_RS36300	COG2217	Heavy metal translocating P-type atpase
AL536_RS36310	COG2010	Cytochrome c
AL536_RS36325	COG3278	Belongs to the heme-copper respiratory oxidase family
AL536_RS36340	COG2205	protein histidine kinase activity
AL536_RS36340	COG0784	Response regulator, receiver
AL536_RS36440	COG3120	sequence-specific DNA binding
AL536_RS36445	COG1067	ATP-dependent peptidase activity
AL536_RS36450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL536_RS36465	COG0488	(ABC) transporter
AL536_RS36475	COG0116	Belongs to the methyltransferase superfamily
AL536_RS36475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL536_RS36485	COG0167	dihydroorotate dehydrogenase activity
AL536_RS36500	COG0308	aminopeptidase N
AL536_RS36520	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL536_RS36525	COG1956	GAF domain-containing protein
AL536_RS36530	COG1132	(ABC) transporter
AL536_RS36535	COG2995	paraquat-inducible protein a
AL536_RS36540	COG3008	intermembrane lipid transfer
AL536_RS36550	COG2996	Protein conserved in bacteria
AL536_RS36565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL536_RS36565	COG0574	Belongs to the PEP-utilizing enzyme family
AL536_RS36570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL536_RS36575	COG1666	GTP binding
AL536_RS36580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL536_RS36590	COG1115	amino acid carrier protein
AL536_RS36615	COG3501	Rhs element vgr protein
AL536_RS36625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL536_RS36635	COG1643	Atp-dependent helicase
AL536_RS36640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL536_RS36650	COG3005	denitrification pathway
AL536_RS36675	COG3706	GGDEF domain
AL536_RS36690	COG0443	Heat shock 70 kDa protein
AL536_RS36695	COG3706	GGDEF domain
AL536_RS36705	COG5001	Diguanylate cyclase
AL536_RS36705	COG3300	MHYT domain
AL536_RS36720	COG2999	glutathione oxidoreductase activity
AL536_RS36750	COG0243	molybdopterin cofactor binding
AL536_RS36755	COG3005	denitrification pathway
AL536_RS36765	COG0602	queuosine metabolic process
AL536_RS36770	COG0561	phosphatase activity
AL536_RS36780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL536_RS36785	COG4597	amino acid ABC transporter
AL536_RS36790	COG0765	amino acid transport
AL536_RS36795	COG1126	abc transporter atp-binding protein
AL536_RS36800	COG0670	Belongs to the BI1 family
AL536_RS36805	COG2920	part of a sulfur-relay system
AL536_RS36810	COG1254	Belongs to the acylphosphatase family
AL536_RS36815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL536_RS36820	COG3391	amine dehydrogenase activity
AL536_RS36865	COG5002	protein histidine kinase activity
AL536_RS36870	COG0745	RESPONSE REGULATOR receiver
AL536_RS36885	COG0668	transmembrane transport
AL536_RS36920	COG1278	Cold shock
AL536_RS36980	COG0835	chemotaxis
AL536_RS36980	COG0784	Response regulator, receiver
AL536_RS36990	COG4565	transcriptional regulatory protein
AL536_RS36995	COG3290	protein histidine kinase activity
AL536_RS37010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL536_RS37030	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL536_RS37035	COG3063	Type IV pilus biogenesis stability protein PilW
AL536_RS37050	COG1451	nucleotide metabolic process
AL536_RS37060	COG0583	DNA-binding transcription factor activity
AL536_RS37110	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL536_RS37115	COG4139	cobalamin transport
AL536_RS37120	COG2988	succinylglutamate desuccinylase activity
AL536_RS37135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL536_RS37140	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL536_RS37145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL536_RS37150	COG0702	epimerase
AL536_RS37155	COG1823	symporter activity
AL536_RS37165	COG2925	Exonuclease
AL536_RS37170	COG1380	Effector of murein hydrolase LrgA
AL536_RS37175	COG1346	cytolysis
AL536_RS37180	COG0295	cytidine deaminase activity
AL536_RS37185	COG5001	Diguanylate cyclase
AL536_RS37215	COG0500	methyltransferase
AL536_RS37225	COG0776	regulation of translation
AL536_RS37230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL536_RS37230	COG0072	phenylalanine-tRNA ligase activity
AL536_RS37235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL536_RS37255	COG2133	pyrroloquinoline quinone binding
AL536_RS37290	COG0322	excinuclease ABC activity
AL536_RS37295	COG2197	response regulator
AL536_RS37300	COG0417	DNA replication proofreading
AL536_RS37305	COG5001	Diguanylate cyclase
AL536_RS37315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL536_RS37320	COG3099	Belongs to the UPF0263 family
AL536_RS37335	COG1228	amidohydrolase
AL536_RS37340	COG0010	Belongs to the arginase family
AL536_RS37350	COG2986	histidine ammonia-lyase
AL536_RS37370	COG0277	FAD linked oxidase domain protein
AL536_RS37370	COG0247	lactate metabolic process
AL536_RS37385	COG2885	chlorophyll binding
AL536_RS37405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL536_RS37410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL536_RS37415	COG1012	belongs to the aldehyde dehydrogenase family
AL536_RS37420	COG2957	Belongs to the agmatine deiminase family
AL536_RS37430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL536_RS37435	COG1012	belongs to the aldehyde dehydrogenase family
AL536_RS37440	COG1396	sequence-specific DNA binding
AL536_RS37440	COG1917	Cupin 2, conserved barrel domain protein
AL536_RS37445	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL536_RS37450	COG0174	glutamine synthetase
AL536_RS37465	COG1643	Atp-dependent helicase
AL536_RS37470	COG0281	malic enzyme
AL536_RS37490	COG0583	DNA-binding transcription factor activity
AL536_RS37505	COG0640	Transcriptional regulator
AL536_RS37530	COG2949	membrane
AL536_RS37540	COG1414	Transcriptional regulator
AL536_RS37545	COG1414	Transcriptional regulator
AL536_RS37555	COG1454	alcohol dehydrogenase
AL536_RS37560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL536_RS37580	COG0492	ferredoxin-NADP+ reductase activity
AL536_RS37585	COG4988	ABC transporter
AL536_RS37590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL536_RS37615	COG1187	pseudouridine synthase activity
AL536_RS37620	COG0009	L-threonylcarbamoyladenylate synthase
AL536_RS37625	COG0613	PHP domain protein
AL536_RS37635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL536_RS37640	COG0512	Glutamine amidotransferase of anthranilate synthase
AL536_RS37645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL536_RS37650	COG0134	indole-3-glycerol-phosphate synthase activity
AL536_RS37650	COG0135	phosphoribosylanthranilate isomerase activity
AL536_RS37655	COG0133	tryptophan synthase activity
AL536_RS37660	COG0159	tryptophan synthase activity
AL536_RS37665	COG1301	dicarboxylic acid transport
AL536_RS37685	COG2350	Protein conserved in bacteria
AL536_RS37695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL536_RS37700	COG0583	DNA-binding transcription factor activity
AL536_RS37715	COG0612	Peptidase, M16
AL536_RS37735	COG0625	glutathione transferase activity
AL536_RS37745	COG2771	luxR family
AL536_RS37745	COG2200	EAL domain
AL536_RS37750	COG0840	transmembrane signaling receptor activity
AL536_RS37765	COG1794	racemase activity, acting on amino acids and derivatives
AL536_RS37770	COG0346	lactoylglutathione lyase activity
AL536_RS37775	COG5002	protein histidine kinase activity
AL536_RS37780	COG0745	RESPONSE REGULATOR receiver
AL536_RS37800	COG0488	(ABC) transporter
AL536_RS37805	COG1032	radical SAM domain protein
AL536_RS37810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL536_RS37820	COG3852	Histidine kinase
AL536_RS37835	COG3070	regulator of competence-specific genes
AL536_RS37845	COG2431	L-lysine efflux transmembrane transporter activity
AL536_RS37855	COG0076	glutamate decarboxylase activity
AL536_RS37860	COG1737	Transcriptional regulator
AL536_RS37865	COG1979	alcohol dehydrogenase
AL536_RS37870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL536_RS37880	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL536_RS37885	COG1960	acyl-CoA dehydrogenase activity
AL536_RS37905	COG1012	belongs to the aldehyde dehydrogenase family
AL536_RS37920	COG5002	protein histidine kinase activity
AL536_RS37920	COG0784	Response regulator, receiver
AL536_RS37930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL536_RS37935	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL536_RS37940	COG2885	chlorophyll binding
AL536_RS37945	COG0823	Involved in the tonB-independent uptake of proteins
AL536_RS37960	COG0811	peptide transport
AL536_RS37965	COG0824	Thioesterase
AL536_RS37975	COG4890	Cyd operon protein YbgT
AL536_RS37980	COG1294	oxidase, subunit
AL536_RS37985	COG1271	oxidase subunit
AL536_RS37990	COG2255	four-way junction helicase activity
AL536_RS37995	COG0632	four-way junction helicase activity
AL536_RS38000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL536_RS38005	COG0215	cysteine-tRNA ligase activity
AL536_RS38010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL536_RS38015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL536_RS38020	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL536_RS38025	COG3012	SEC-C Motif Domain Protein
AL536_RS38030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL536_RS38035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL536_RS38040	COG1199	ATP-dependent helicase activity
AL536_RS38045	COG3923	Primosomal replication protein n
AL536_RS38060	COG0708	Exodeoxyribonuclease III
AL536_RS38065	COG4160	amino acid transport
AL536_RS38090	COG1882	Formate acetyltransferase
AL536_RS38105	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL536_RS38115	COG3013	Belongs to the UPF0304 family
AL536_RS38125	COG2766	serine protein kinase
AL536_RS38130	COG2718	Belongs to the UPF0229 family
AL536_RS38135	COG2719	SpoVR family
AL536_RS38140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL536_RS38155	COG1132	(ABC) transporter
AL536_RS38160	COG0658	competence protein
AL536_RS38160	COG2333	competence protein COMEC
AL536_RS38170	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL536_RS38175	COG1136	(ABC) transporter
AL536_RS38180	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL536_RS38190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL536_RS38205	COG1252	NADH dehydrogenase
AL536_RS38210	COG3150	esterase
AL536_RS38235	COG0537	adenosine 5'-monophosphoramidase activity
AL536_RS38250	COG2186	Transcriptional regulator
AL536_RS38255	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL536_RS38260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL536_RS38265	COG1674	ftsk spoiiie
AL536_RS38270	COG1522	sequence-specific DNA binding
AL536_RS38275	COG0686	Belongs to the AlaDH PNT family
AL536_RS38285	COG0583	DNA-binding transcription factor activity
AL536_RS38300	COG0284	orotidine-5'-phosphate decarboxylase activity
AL536_RS38305	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL536_RS38310	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL536_RS38315	COG0776	regulation of translation
AL536_RS38320	COG0539	negative regulation of cytoplasmic translation
AL536_RS38325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL536_RS38330	COG1555	photosystem II stabilization
AL536_RS38335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL536_RS38340	COG0776	regulation of translation
AL536_RS38345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL536_RS38350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL536_RS38360	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL536_RS38370	COG4191	Histidine kinase
AL536_RS38375	COG2204	response regulator
AL536_RS38380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL536_RS38385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL536_RS38390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL536_RS38395	COG1404	Belongs to the peptidase S8 family
AL536_RS38400	COG1653	transport
AL536_RS38420	COG1760	l-serine dehydratase
AL536_RS38430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL536_RS38430	COG3153	acetyltransferase
AL536_RS38440	COG5001	Diguanylate cyclase
AL536_RS38440	COG1716	ATPase activity
AL536_RS38450	COG4589	Belongs to the CDS family
AL536_RS38490	COG2197	response regulator
AL536_RS38495	COG3851	Histidine kinase
AL536_RS38500	COG2271	Major facilitator Superfamily
AL536_RS38505	COG1840	ABC-type Fe3 transport system, periplasmic component
AL536_RS38515	COG3842	ATPase activity
AL536_RS38530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL536_RS38535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL536_RS38545	COG2951	lytic endotransglycosylase activity
AL536_RS38550	COG3100	YcgL domain-containing protein
AL536_RS38565	COG2894	cell division
AL536_RS38570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL536_RS38580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL536_RS38585	COG0318	PFAM AMP-dependent synthetase and ligase
AL536_RS38605	COG1214	PFAM Peptidase M22, glycoprotease
AL536_RS38610	COG1199	ATP-dependent helicase activity
AL536_RS38620	COG0788	formyltetrahydrofolate deformylase activity
AL536_RS38625	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL536_RS38625	COG1902	pentaerythritol trinitrate reductase activity
AL536_RS38630	COG0616	signal peptide processing
AL536_RS38635	COG0252	asparaginase activity
AL536_RS38640	COG3139	Protein of unknown function (DUF1315)
AL536_RS38650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL536_RS38655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL536_RS38665	COG2226	methyltransferase
AL536_RS38685	COG2983	Belongs to the UPF0260 family
AL536_RS38695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL536_RS38700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL536_RS38705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL536_RS38715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL536_RS38720	COG2832	Protein of unknown function (DUF454)
AL536_RS38730	COG0745	RESPONSE REGULATOR receiver
AL536_RS38735	COG0583	DNA-binding transcription factor activity
AL536_RS38740	COG0778	Nitroreductase
AL536_RS38745	COG1024	Enoyl-CoA hydratase
AL536_RS38745	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL536_RS38750	COG0183	Belongs to the thiolase family
AL536_RS38765	COG2067	long-chain fatty acid transport protein
AL536_RS38775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL536_RS38790	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL536_RS38795	COG2982	Protein involved in outer membrane biogenesis
AL536_RS38800	COG0572	uridine kinase
AL536_RS38805	COG0489	protein tyrosine kinase activity
AL536_RS38810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL536_RS38810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL536_RS38820	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL536_RS38830	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL536_RS38830	COG0617	tRNA 3'-terminal CCA addition
AL536_RS38830	COG0517	IMP dehydrogenase activity
AL536_RS38835	COG3706	GGDEF domain
AL536_RS38840	COG0314	molybdopterin synthase activity
AL536_RS38845	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL536_RS38850	COG0315	cyclic pyranopterin monophosphate synthase activity
AL536_RS38855	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL536_RS38860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL536_RS38865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL536_RS38870	COG2198	Histidine kinase
AL536_RS38875	COG2204	response regulator
AL536_RS38880	COG0556	nucleotide-excision repair
AL536_RS38890	COG0582	viral genome integration into host DNA
AL536_RS38915	COG4251	negative regulation of phosphorylation
AL536_RS38915	COG2203	Gaf domain
AL536_RS38915	COG5001	Diguanylate cyclase
AL536_RS38915	COG3706	GGDEF domain
AL536_RS38945	COG3706	GGDEF domain
AL536_RS38975	COG4657	Part of a membrane complex involved in electron transport
AL536_RS38980	COG2878	Part of a membrane complex involved in electron transport
AL536_RS38985	COG4656	Part of a membrane complex involved in electron transport
AL536_RS38990	COG4658	electron transport chain
AL536_RS38995	COG4659	FMN binding
AL536_RS39000	COG4660	Part of a membrane complex involved in electron transport
AL536_RS39005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL536_RS39010	COG0346	lactoylglutathione lyase activity
AL536_RS39025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL536_RS39030	COG2056	Na+-H+ antiporter family
AL536_RS39035	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL536_RS39040	COG1286	toxin biosynthetic process
AL536_RS39045	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL536_RS39050	COG0285	dihydrofolate synthase activity
AL536_RS39055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL536_RS39060	COG0101	tRNA pseudouridine synthase activity
AL536_RS39075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL536_RS39075	COG2190	(PTS) system
AL536_RS39075	COG1263	PTS System
AL536_RS39080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL536_RS39085	COG1846	Transcriptional regulator
AL536_RS39085	COG1940	carbohydrate kinase activity
AL536_RS39090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL536_RS39090	COG4651	solute:proton antiporter activity
AL536_RS39095	COG0367	asparagine synthase
AL536_RS39105	COG3104	oligopeptide transport
AL536_RS39110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL536_RS39120	COG0326	Molecular chaperone. Has ATPase activity
AL536_RS39125	COG3710	Transcriptional regulator
AL536_RS39140	COG0622	Phosphoesterase
AL536_RS39165	COG1090	epimerase
AL536_RS39170	COG0300	oxidoreductase activity
AL536_RS39180	COG3118	belongs to the thioredoxin family
AL536_RS39185	COG0330	HflC and HflK could
AL536_RS39195	COG0789	Transcriptional regulator
AL536_RS39210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL536_RS39215	COG3115	cell septum assembly
AL536_RS39220	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL536_RS39225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL536_RS39235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL536_RS39245	COG2190	(PTS) system
AL536_RS39250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL536_RS39255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL536_RS39260	COG1702	phosphate starvation-inducible protein PhoH
AL536_RS39265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL536_RS39270	COG4535	Mg2 and Co2 transporter CorC
AL536_RS39275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL536_RS39280	COG2888	peptidyl-tyrosine sulfation
AL536_RS39290	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL536_RS39295	COG1466	dna polymerase III delta subunit
AL536_RS39300	COG0799	negative regulation of ribosome biogenesis
AL536_RS39305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL536_RS39310	COG0768	penicillin binding
AL536_RS39315	COG0772	Belongs to the SEDS family
AL536_RS39320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL536_RS39325	COG1686	Belongs to the peptidase S11 family
AL536_RS39330	COG2921	Belongs to the UPF0250 family
AL536_RS39335	COG0321	lipoyl(octanoyl) transferase activity
AL536_RS39340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL536_RS39350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL536_RS39360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL536_RS39365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL536_RS39390	COG0366	Alpha amylase catalytic
AL536_RS39395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL536_RS39395	COG1263	PTS System
AL536_RS39410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL536_RS39415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL536_RS39420	COG2011	ABC-type metal ion transport system permease component
AL536_RS39425	COG1464	Belongs to the NlpA lipoprotein family
AL536_RS39430	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL536_RS39440	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL536_RS39440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL536_RS39455	COG1611	Belongs to the LOG family
AL536_RS39460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL536_RS39470	COG2363	Small membrane protein
AL536_RS39480	COG0583	DNA-binding transcription factor activity
AL536_RS39485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL536_RS39485	COG0301	tRNA thio-modification
AL536_RS39495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL536_RS39500	COG1722	exodeoxyribonuclease VII activity
AL536_RS39505	COG0142	geranyltranstransferase activity
AL536_RS39510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL536_RS39515	COG0564	pseudouridine synthase activity
AL536_RS39520	COG3098	single-species biofilm formation
AL536_RS39545	COG1671	Belongs to the UPF0178 family
AL536_RS39550	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL536_RS39555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL536_RS39560	COG0254	rRNA binding
AL536_RS39565	COG1720	tRNA m6t6A37 methyltransferase activity
AL536_RS39570	COG0442	prolyl-tRNA aminoacylation
AL536_RS39595	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL536_RS39600	COG0590	tRNA wobble adenosine to inosine editing
AL536_RS39605	COG0583	DNA-binding transcription factor activity
AL536_RS39610	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL536_RS39620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL536_RS39645	COG4969	Belongs to the N-Me-Phe pilin family
AL536_RS39650	COG0484	heat shock protein binding
AL536_RS39655	COG0443	Heat shock 70 kDa protein
AL536_RS39665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL536_RS39670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL536_RS39675	COG0497	DNA recombination
AL536_RS39680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL536_RS39685	COG2914	Belongs to the UPF0125 (RnfH) family
AL536_RS39690	COG2867	negative regulation of translational initiation
AL536_RS39695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL536_RS39705	COG0582	viral genome integration into host DNA
AL536_RS39720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL536_RS39740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL536_RS39760	COG2003	Belongs to the UPF0758 family
AL536_RS39790	COG1160	GTP binding
AL536_RS39800	COG0328	RNA-DNA hybrid ribonuclease activity
AL536_RS39840	COG3501	Rhs element vgr protein
AL536_RS39860	COG1401	restriction endodeoxyribonuclease activity
AL536_RS39865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL536_RS39865	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AL536_RS39880	COG0583	DNA-binding transcription factor activity
AL536_RS39890	COG1115	amino acid carrier protein
AL536_RS39900	COG1473	amidohydrolase
AL536_RS39915	COG1584	GPR1 FUN34 yaaH family protein
AL536_RS39925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL536_RS39925	COG0519	Catalyzes the synthesis of GMP from XMP
AL536_RS39930	COG0516	GMP reductase activity
AL536_RS39930	COG0517	IMP dehydrogenase activity
AL536_RS39935	COG1570	exodeoxyribonuclease VII activity
AL536_RS39950	COG1160	GTP binding
AL536_RS39955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL536_RS39960	COG2976	Protein conserved in bacteria
AL536_RS39965	COG0124	histidyl-tRNA synthetase
AL536_RS39970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL536_RS39985	COG0105	UTP biosynthetic process
AL536_RS39990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL536_RS39995	COG2975	iron-sulfur cluster assembly
AL536_RS40000	COG0633	Ferredoxin
AL536_RS40005	COG0443	Heat shock 70 kDa protein
AL536_RS40020	COG0822	iron-sulfur transferase activity
AL536_RS40025	COG1104	cysteine desulfurase activity
AL536_RS40030	COG1959	2 iron, 2 sulfur cluster binding
AL536_RS40035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL536_RS40040	COG0483	inositol monophosphate 1-phosphatase activity
AL536_RS40045	COG1335	isochorismatase
AL536_RS40050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL536_RS40055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL536_RS40060	COG1862	Preprotein translocase
AL536_RS40070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL536_RS40075	COG0517	IMP dehydrogenase activity
AL536_RS40085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL536_RS40090	COG0583	DNA-binding transcription factor activity
AL536_RS40095	COG0450	alkyl hydroperoxide reductase
AL536_RS40110	COG0704	Plays a role in the regulation of phosphate uptake
AL536_RS40115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL536_RS40120	COG0581	inorganic phosphate transmembrane transporter activity
AL536_RS40125	COG0573	inorganic phosphate transmembrane transporter activity
AL536_RS40135	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL536_RS40140	COG0248	Ppx GppA phosphatase
AL536_RS40150	COG5002	protein histidine kinase activity
AL536_RS40155	COG0745	RESPONSE REGULATOR receiver
AL536_RS40165	COG0826	peptidase U32
AL536_RS40170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL536_RS40175	COG0477	Major facilitator Superfamily
AL536_RS40185	COG1595	DNA-templated transcription, initiation
AL536_RS40195	COG3248	Nucleoside-binding outer membrane protein
AL536_RS40200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL536_RS40205	COG0693	protein deglycase activity
AL536_RS40210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL536_RS40220	COG2166	iron-sulfur cluster assembly
AL536_RS40225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL536_RS40230	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL536_RS40240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL536_RS40240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL536_RS40250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL536_RS40255	COG1074	ATP-dependent DNA helicase activity
AL536_RS40260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL536_RS40270	COG0583	DNA-binding transcription factor activity
AL536_RS40275	COG3141	response to X-ray
AL536_RS40280	COG2171	N-acyltransferase activity
AL536_RS40285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL536_RS40300	COG0569	domain protein
AL536_RS40300	COG0189	ligase activity
AL536_RS40315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL536_RS40320	COG2017	converts alpha-aldose to the beta-anomer
AL536_RS40330	COG2059	Chromate
AL536_RS40335	COG3437	response regulator, receiver
AL536_RS40335	COG0784	Response regulator, receiver
AL536_RS40385	COG4964	Belongs to the GSP D family
AL536_RS40425	COG0583	DNA-binding transcription factor activity
AL536_RS40435	COG0583	DNA-binding transcription factor activity
AL536_RS40440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL536_RS40445	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL536_RS40455	COG0560	Phosphoserine phosphatase
AL536_RS40465	COG0813	purine-nucleoside phosphorylase activity
AL536_RS40470	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL536_RS40475	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL536_RS40480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL536_RS40490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL536_RS40495	COG1744	ABC transporter substrate-binding protein PnrA-like
AL536_RS40500	COG3845	ABC transporter
AL536_RS40505	COG4603	Belongs to the binding-protein-dependent transport system permease family
AL536_RS40510	COG1079	Belongs to the binding-protein-dependent transport system permease family
AL536_RS40515	COG0084	hydrolase, TatD family'
AL536_RS40520	COG3022	response to hydroperoxide
AL536_RS40525	COG1115	amino acid carrier protein
AL536_RS40540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL536_RS40550	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL536_RS40555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL536_RS40560	COG0083	homoserine kinase activity
AL536_RS40580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL536_RS40595	COG0745	RESPONSE REGULATOR receiver
AL536_RS40605	COG5002	protein histidine kinase activity
AL536_RS40605	COG0784	Response regulator, receiver
AL536_RS40605	COG2198	Histidine kinase
AL536_RS40610	COG4251	negative regulation of phosphorylation
AL536_RS40610	COG5001	Diguanylate cyclase
AL536_RS40610	COG3706	GGDEF domain
AL536_RS40610	COG2203	Gaf domain
AL536_RS40615	COG1242	4 iron, 4 sulfur cluster binding
AL536_RS40620	COG0067	glutamate synthase
AL536_RS40620	COG0069	glutamate synthase activity
AL536_RS40620	COG0070	glutamate synthase
AL536_RS40630	COG0070	glutamate synthase
AL536_RS40630	COG0067	glutamate synthase
AL536_RS40630	COG0069	glutamate synthase activity
AL536_RS40635	COG0493	'glutamate synthase
AL536_RS40645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL536_RS40655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL536_RS40660	COG2860	membrane
AL536_RS40680	COG0583	DNA-binding transcription factor activity
AL536_RS40685	COG0730	response to heat
AL536_RS40690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL536_RS40695	COG0505	Belongs to the CarA family
AL536_RS40700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL536_RS40705	COG0494	nUDIX hydrolase
AL536_RS40710	COG0653	protein targeting
AL536_RS40720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL536_RS40725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL536_RS40730	COG0849	cell division
AL536_RS40735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL536_RS40740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL536_RS40745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL536_RS40750	COG0772	Belongs to the SEDS family
AL536_RS40755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL536_RS40765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL536_RS40770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL536_RS40775	COG0768	penicillin binding
AL536_RS40780	COG3116	cell division
AL536_RS40795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL536_RS40800	COG3107	peptidoglycan biosynthetic process
AL536_RS40805	COG0792	nuclease activity
AL536_RS40810	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL536_RS40815	COG2823	Periplasmic or secreted lipoprotein
AL536_RS40820	COG2969	positive regulation of protein catabolic process
AL536_RS40825	COG0625	glutathione transferase activity
AL536_RS40830	COG2857	Cytochrome c1
AL536_RS40835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL536_RS40840	COG0723	plastoquinol--plastocyanin reductase activity
AL536_RS40845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL536_RS40850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL536_RS40860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL536_RS40865	COG3105	Protein conserved in bacteria
AL536_RS40870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL536_RS40875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL536_RS40880	COG0335	large ribosomal subunit rRNA binding
AL536_RS40885	COG0336	Belongs to the RNA methyltransferase TrmD family
AL536_RS40890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL536_RS40900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL536_RS40905	COG4137	Cytochrome C assembly protein
AL536_RS40910	COG4536	flavin adenine dinucleotide binding
AL536_RS40915	COG1854	S-ribosylhomocysteine lyase activity
AL536_RS40930	COG0612	Peptidase, M16
AL536_RS40935	COG1238	metal cluster binding
AL536_RS40945	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL536_RS40950	COG5016	pyruvate
AL536_RS40950	COG0511	ligase activity, forming carbon-carbon bonds
AL536_RS40955	COG3630	sodium ion export across plasma membrane
AL536_RS41005	COG0527	aspartate kinase activity
AL536_RS41010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL536_RS41020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL536_RS41025	COG1546	Belongs to the CinA family
AL536_RS41030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL536_RS41035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL536_RS41040	COG4942	peptidase
AL536_RS41040	COG1388	LysM domain
AL536_RS41050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL536_RS41055	COG0585	pseudouridine synthase activity
AL536_RS41065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL536_RS41070	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL536_RS41075	COG1968	undecaprenyl-diphosphatase activity
AL536_RS41080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL536_RS41085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL536_RS41090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL536_RS41100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL536_RS41105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL536_RS41110	COG1610	YqeY-like protein
AL536_RS41140	COG2239	Acts as a magnesium transporter
AL536_RS41160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL536_RS41195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL536_RS41225	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AL536_RS41230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL536_RS41235	COG1349	DNA-binding transcription factor activity
AL536_RS41250	COG3706	GGDEF domain
AL536_RS41275	COG0668	transmembrane transport
AL536_RS41280	COG0191	fructose-bisphosphate aldolase activity
AL536_RS41285	COG0126	phosphoglycerate kinase activity
AL536_RS41290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL536_RS41295	COG4771	TonB-dependent receptor
AL536_RS41300	COG0583	DNA-binding transcription factor activity
AL536_RS41305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL536_RS41310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL536_RS41325	COG2356	endonuclease I
AL536_RS41330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL536_RS41335	COG0189	ligase activity
AL536_RS41340	COG1678	Uncharacterized ACR, COG1678
AL536_RS41345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL536_RS41360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL536_RS41365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL536_RS41370	COG0762	integral membrane protein
AL536_RS41375	COG1872	DUF167
AL536_RS41385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL536_RS41390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL536_RS41395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL536_RS41400	COG2066	Belongs to the glutaminase family
AL536_RS41410	COG1194	a g-specific adenine glycosylase
AL536_RS41415	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL536_RS41420	COG0741	lytic transglycosylase activity
AL536_RS41475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL536_RS41480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL536_RS41485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL536_RS41490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL536_RS41495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL536_RS41500	COG2967	ApaG domain
AL536_RS41515	COG3610	response to peptide
AL536_RS41520	COG2966	Psort location CytoplasmicMembrane, score
AL536_RS41525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL536_RS41535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL536_RS41540	COG0142	geranyltranstransferase activity
AL536_RS41545	COG0531	amino acid
AL536_RS41550	COG0039	L-malate dehydrogenase activity
AL536_RS41555	COG1438	arginine binding
AL536_RS41570	COG0589	response to stress
AL536_RS41590	COG0312	modulator of DNA gyrase
AL536_RS41595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL536_RS41600	COG3164	Protein of unknown function
AL536_RS41605	COG1530	ribonuclease E activity
AL536_RS41610	COG0424	maF-like protein
AL536_RS41615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL536_RS41620	COG1792	Involved in formation and maintenance of cell shape
AL536_RS41625	COG1077	Cell shape determining protein MreB Mrl
AL536_RS41660	COG2165	general secretion pathway protein
AL536_RS41670	COG1459	type II secretion system
AL536_RS41675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL536_RS41685	COG3267	Type II secretory pathway component ExeA
AL536_RS41685	COG3409	Peptidoglycan-binding domain 1 protein
AL536_RS41710	COG2200	EAL domain
AL536_RS41710	COG2199	diguanylate cyclase activity
AL536_RS41715	COG0629	single-stranded DNA binding
AL536_RS41730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL536_RS41740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL536_RS41745	COG0527	aspartate kinase activity
AL536_RS41750	COG0646	methionine synthase
AL536_RS41750	COG1410	methionine synthase
AL536_RS41830	COG0175	sulfate reduction
AL536_RS41840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL536_RS41860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL536_RS41865	COG0735	belongs to the Fur family
AL536_RS41875	COG0166	Belongs to the GPI family
AL536_RS41885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL536_RS41900	COG0359	binds to the 23S rRNA
AL536_RS41910	COG2965	DNA replication, synthesis of RNA primer
AL536_RS41915	COG0360	Binds together with S18 to 16S ribosomal RNA
AL536_RS41925	COG2906	2 iron, 2 sulfur cluster binding
AL536_RS41935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL536_RS41940	COG0049	tRNA binding
AL536_RS41950	COG2168	tRNA wobble position uridine thiolation
AL536_RS41955	COG2923	Belongs to the DsrF TusC family
AL536_RS41960	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL536_RS41965	COG2964	Protein conserved in bacteria
AL536_RS41970	COG0545	Peptidyl-prolyl cis-trans isomerase
AL536_RS41980	COG2900	Belongs to the SlyX family
AL536_RS41985	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL536_RS41990	COG0330	HflC and HflK could
AL536_RS41995	COG0330	HflC and HflK could
AL536_RS42000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL536_RS42005	COG1923	regulation of RNA biosynthetic process
AL536_RS42010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL536_RS42015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL536_RS42025	COG0802	atpase or kinase
AL536_RS42030	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL536_RS42085	COG1162	GTPase activity
AL536_RS42090	COG0688	phosphatidylethanolamine metabolic process
AL536_RS42095	COG0471	metal ion transport
AL536_RS42095	COG0490	domain, Protein
AL536_RS42110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL536_RS42115	COG4942	peptidase
AL536_RS42130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL536_RS42135	COG2816	NAD+ diphosphatase activity
AL536_RS42140	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL536_RS42145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL536_RS42150	COG0085	RNA polymerase activity
AL536_RS42155	COG0222	ribosome binding
AL536_RS42160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL536_RS42170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL536_RS42175	COG0250	Participates in transcription elongation, termination and antitermination
AL536_RS42180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL536_RS42215	COG1072	(Pantothenic acid kinase))
AL536_RS42225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL536_RS42235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL536_RS42300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL536_RS42315	COG3118	belongs to the thioredoxin family
AL536_RS42320	COG0513	Belongs to the DEAD box helicase family
AL536_RS42325	COG0248	Ppx GppA phosphatase
AL536_RS42330	COG2198	Histidine kinase
AL536_RS42330	COG2205	protein histidine kinase activity
AL536_RS42330	COG0784	Response regulator, receiver
AL536_RS42330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL536_RS42335	COG2814	Major facilitator Superfamily
AL536_RS42350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL536_RS42355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL536_RS42360	COG0511	ligase activity, forming carbon-carbon bonds
AL536_RS42365	COG0439	Biotin carboxylase
AL536_RS42370	COG2264	protein methyltransferase activity
AL536_RS42375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL536_RS42380	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL536_RS42385	COG0840	transmembrane signaling receptor activity
AL536_RS42390	COG0789	Transcriptional regulator
AL536_RS42400	COG0138	bifunctional purine biosynthesis protein purh
AL536_RS42405	COG0151	Belongs to the GarS family
AL536_RS42415	COG0776	regulation of translation
AL536_RS42420	COG1253	flavin adenine dinucleotide binding
AL536_RS42425	COG0668	transmembrane transport
AL536_RS42430	COG3068	Protein conserved in bacteria
AL536_RS42435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL536_RS42440	COG1573	uracil-dna glycosylase
AL536_RS42445	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL536_RS42450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL536_RS42475	COG1086	Polysaccharide biosynthesis protein
AL536_RS42485	COG0438	transferase activity, transferring glycosyl groups
AL536_RS42490	COG4641	Protein conserved in bacteria
AL536_RS42490	COG1388	LysM domain
AL536_RS42545	COG1596	polysaccharide export
AL536_RS42565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL536_RS42570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL536_RS42580	COG1560	Kdo2-lipid A biosynthetic process
AL536_RS42590	COG0859	PFAM glycosyl transferase family 9
AL536_RS42595	COG0859	PFAM glycosyl transferase family 9
AL536_RS42600	COG1519	Transferase
AL536_RS42605	COG0438	transferase activity, transferring glycosyl groups
AL536_RS42610	COG3642	lipopolysaccharide core region biosynthetic process
AL536_RS42615	COG0859	PFAM glycosyl transferase family 9
AL536_RS42620	COG0463	Glycosyl transferase, family 2
AL536_RS42625	COG0438	transferase activity, transferring glycosyl groups
AL536_RS42630	COG0438	transferase activity, transferring glycosyl groups
AL536_RS42635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL536_RS42650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL536_RS42660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL536_RS42665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL536_RS42670	COG2003	Belongs to the UPF0758 family
AL536_RS42680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL536_RS42685	COG1309	transcriptional regulator
AL536_RS42690	COG1560	Kdo2-lipid A biosynthetic process
AL536_RS42695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL536_RS42700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL536_RS42705	COG1561	YicC-like family, N-terminal region
AL536_RS42710	COG2862	Uncharacterized protein family, UPF0114
AL536_RS42725	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL536_RS42730	COG1120	ATPase activity
AL536_RS42735	COG1132	(ABC) transporter
AL536_RS42750	COG0514	ATP-dependent DNA helicase (RecQ)
AL536_RS42755	COG2962	Rard protein
AL536_RS42765	COG1280	lysine exporter protein (LysE YggA)
AL536_RS42770	COG0405	Gamma-glutamyltransferase
AL536_RS42785	COG0210	DNA helicase
AL536_RS42820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL536_RS42825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL536_RS42840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL536_RS42845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL536_RS42855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL536_RS42860	COG0601	transmembrane transport
AL536_RS42865	COG0747	negative chemotaxis
AL536_RS42905	COG0210	DNA helicase
AL536_RS42915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL536_RS42920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL536_RS42925	COG2960	long-chain fatty acid transporting porin activity
AL536_RS42930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL536_RS42935	COG0583	DNA-binding transcription factor activity
AL536_RS42985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL536_RS42995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL536_RS43000	COG0408	coproporphyrinogen oxidase activity
AL536_RS43010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL536_RS43015	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL536_RS43020	COG0551	DNA topoisomerase type I activity
AL536_RS43025	COG2922	Belongs to the Smg family
AL536_RS43030	COG0758	DNA mediated transformation
AL536_RS43035	COG1652	LysM domain
AL536_RS43040	COG0242	peptide deformylase activity
AL536_RS43050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL536_RS43050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL536_RS43055	COG0569	domain protein
AL536_RS43060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL536_RS43070	COG1272	protein, Hemolysin III
AL536_RS43075	COG4326	sporulation control protein
AL536_RS43085	COG3084	Protein conserved in bacteria
AL536_RS43095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL536_RS43100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL536_RS43105	COG0204	Acyl-transferase
AL536_RS43110	COG0606	chelatase, subunit chli
AL536_RS43120	COG3978	acetolactate synthase activity
AL536_RS43125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL536_RS43140	COG0604	alcohol dehydrogenase
AL536_RS43155	COG0425	Belongs to the sulfur carrier protein TusA family
AL536_RS43165	COG2119	membrane
AL536_RS43170	COG0752	glycyl-tRNA synthetase alpha subunit
AL536_RS43175	COG0751	glycine-tRNA ligase activity
AL536_RS43180	COG3977	Valine--pyruvate aminotransferase
AL536_RS43185	COG0071	Belongs to the small heat shock protein (HSP20) family
AL536_RS43190	COG0187	DNA topoisomerase II activity
AL536_RS43195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL536_RS43200	COG0592	DNA-directed DNA polymerase activity
AL536_RS43205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL536_RS43220	COG1126	abc transporter atp-binding protein
AL536_RS43225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL536_RS43240	COG0706	membrane insertase activity
AL536_RS43245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL536_RS43250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL536_RS43255	COG0445	tRNA wobble uridine modification
AL536_RS43260	COG0357	Ribosomal RNA small subunit methyltransferase G
AL536_RS43265	COG1192	Involved in chromosome partitioning
AL536_RS43270	COG1475	DNA binding
AL536_RS43275	COG3312	ion transport
AL536_RS43290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL536_RS43295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL536_RS43300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL536_RS43305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL536_RS43310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL536_RS43315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL536_RS43325	COG0765	amino acid transport
AL536_RS43330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL536_RS43335	COG2814	Major facilitator Superfamily
AL536_RS43340	COG0583	DNA-binding transcription factor activity
AL536_RS43345	COG0183	Belongs to the thiolase family
AL536_RS43355	COG1739	Uncharacterized protein family UPF0029
AL536_RS43360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL536_RS43415	COG2132	Multicopper oxidase
AL536_RS43420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL536_RS43425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL536_RS43435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL536_RS43440	COG2104	thiamine diphosphate biosynthetic process
AL536_RS43440	COG2022	thiamine diphosphate biosynthetic process
AL536_RS43445	COG2022	thiamine diphosphate biosynthetic process
AL536_RS43450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL536_RS43455	COG4175	Glycine betaine
AL536_RS43475	COG1012	belongs to the aldehyde dehydrogenase family
AL536_RS43480	COG1309	transcriptional regulator
AL536_RS43485	COG0006	proline dipeptidase activity
AL536_RS43485	COG0006	proline dipeptidase activity
AL536_RS43505	COG1522	sequence-specific DNA binding
AL536_RS43510	COG5001	Diguanylate cyclase
AL536_RS43510	COG5002	protein histidine kinase activity
AL536_RS43530	COG0589	response to stress
AL536_RS43535	COG1528	Iron-storage protein
AL536_RS43545	COG2081	HI0933 family
AL536_RS43550	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL536_RS43555	COG1129	ABC transporter
AL536_RS43560	COG1879	ABC-type sugar transport system periplasmic component
AL536_RS43565	COG1069	ribulokinase activity
AL536_RS43570	COG0235	Class ii aldolase
AL536_RS43575	COG2160	L-arabinose isomerase activity
AL536_RS43600	COG1322	Protein conserved in bacteria
AL536_RS43605	COG2226	methyltransferase
AL536_RS43610	COG3165	ubiquinone biosynthetic process from chorismate
AL536_RS43615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL536_RS43620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL536_RS43625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL536_RS43630	COG0805	protein transport
AL536_RS43635	COG0084	hydrolase, TatD family'
AL536_RS43650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL536_RS43650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL536_RS43685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL536_RS43690	COG3071	HemY protein
AL536_RS43695	COG2959	enzyme of heme biosynthesis
AL536_RS43710	COG3072	Adenylate cyclase
AL536_RS43715	COG1965	Belongs to the frataxin family
AL536_RS43725	COG0019	diaminopimelate decarboxylase activity
AL536_RS43730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL536_RS43740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL536_RS43745	COG1011	Hydrolase
AL536_RS43750	COG2199	diguanylate cyclase activity
AL536_RS43750	COG3287	FIST C domain
AL536_RS43750	COG2200	EAL domain
AL536_RS43755	COG3148	PFAM DTW domain containing protein
AL536_RS43770	COG0561	phosphatase activity
AL536_RS43775	COG2267	carboxylic ester hydrolase activity
AL536_RS43780	COG1280	lysine exporter protein (LysE YggA)
AL536_RS43785	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL536_RS43790	COG0640	Transcriptional regulator
AL536_RS43795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL536_RS43810	COG0783	Belongs to the Dps family
AL536_RS43845	COG2095	MarC family integral membrane protein
AL536_RS43855	COG0742	ribosomal rna small subunit methyltransferase
AL536_RS43860	COG0552	protein localization to endoplasmic reticulum
AL536_RS43865	COG2884	Cell division ATP-binding protein ftsE
AL536_RS43870	COG2177	Part of the ABC transporter FtsEX involved in
AL536_RS43875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL536_RS43880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL536_RS43885	COG0705	Rhomboid family
AL536_RS43890	COG1580	Controls the rotational direction of flagella during chemotaxis
AL536_RS43895	COG3161	chorismate lyase activity
AL536_RS43900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL536_RS43905	COG2937	Belongs to the GPAT DAPAT family
AL536_RS43910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL536_RS43915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL536_RS43925	COG0534	Mate efflux family protein
AL536_RS43930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL536_RS43975	COG0328	RNA-DNA hybrid ribonuclease activity
AL536_RS43980	COG1968	undecaprenyl-diphosphatase activity
AL536_RS43990	COG0668	transmembrane transport
AL536_RS43995	COG2814	Major facilitator Superfamily
AL536_RS44000	COG0583	DNA-binding transcription factor activity
AL536_RS44005	COG2771	luxR family
AL536_RS44005	COG2200	EAL domain
AL536_RS44050	COG2003	Belongs to the UPF0758 family
AL536_RS44075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL536_RS44090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL536_RS44150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL536_RS44155	COG5001	Diguanylate cyclase
AL536_RS44155	COG3300	MHYT domain
AL536_RS44160	COG2204	response regulator
AL536_RS44165	COG3852	Histidine kinase
AL536_RS44175	COG0174	glutamine synthetase
AL536_RS44180	COG1217	gtp-binding protein TYPA
AL536_RS44200	COG1490	D-aminoacyl-tRNA deacylase activity
AL536_RS44205	COG0456	acetyltransferase
AL536_RS44210	COG2982	Protein involved in outer membrane biogenesis
AL536_RS44215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL536_RS44225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL536_RS44230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL536_RS44235	COG3031	protein transport across the cell outer membrane
AL536_RS44245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL536_RS44250	COG1459	type II secretion system
AL536_RS44255	COG2165	general secretion pathway protein
AL536_RS44260	COG2165	general secretion pathway protein
AL536_RS44265	COG2165	general secretion pathway protein
AL536_RS44270	COG4795	General secretion pathway protein
AL536_RS44275	COG3156	type II secretion system protein K
AL536_RS44280	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL536_RS44285	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL536_RS44295	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL536_RS44300	COG0494	nUDIX hydrolase
AL536_RS44310	COG1040	competence protein
AL536_RS44325	COG2183	response to ionizing radiation
AL536_RS44335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL536_RS44340	COG1609	Transcriptional regulator
AL536_RS44345	COG0129	dihydroxy-acid dehydratase activity
AL536_RS44350	COG3265	gluconokinase activity
AL536_RS44355	COG2610	gluconate transmembrane transporter activity
AL536_RS44360	COG0800	Aldolase
AL536_RS44375	COG2233	PERMEase
AL536_RS44380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL536_RS44385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL536_RS44390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL536_RS44395	COG1758	RNA polymerase activity
AL536_RS44400	COG0194	GDP metabolic process
AL536_RS44405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL536_RS44410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL536_RS44430	COG4232	protein-disulfide reductase activity
AL536_RS44440	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL536_RS44445	COG0540	Belongs to the ATCase OTCase family
AL536_RS44450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL536_RS44465	COG1288	antiporter activity
AL536_RS44470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL536_RS44475	COG1027	Aspartate ammonia-lyase
AL536_RS44485	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL536_RS44490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL536_RS44495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL536_RS44500	COG2205	protein histidine kinase activity
AL536_RS44505	COG0745	RESPONSE REGULATOR receiver
AL536_RS44515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL536_RS44520	COG0205	6-phosphofructokinase activity
AL536_RS44525	COG1494	fructose-1,6-bisphosphatase
AL536_RS44530	COG3074	FtsZ-dependent cytokinesis
AL536_RS44535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL536_RS44540	COG0460	homoserine dehydrogenase
AL536_RS44540	COG0527	aspartate kinase activity
AL536_RS44545	COG0626	cystathionine gamma-synthase activity
AL536_RS44550	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL536_RS44555	COG0281	malic enzyme
AL536_RS44560	COG0254	rRNA binding
AL536_RS44565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL536_RS44570	COG1609	Transcriptional regulator
AL536_RS44580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL536_RS44585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL536_RS44590	COG1575	Belongs to the MenA family. Type 1 subfamily
AL536_RS44595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL536_RS44600	COG0534	Mate efflux family protein
AL536_RS44605	COG0149	triose-phosphate isomerase activity
AL536_RS44635	COG0459	protein refolding
AL536_RS44640	COG3344	reverse transcriptase
AL536_RS44645	COG3344	reverse transcriptase
AL536_RS44660	COG1119	ATPase activity
AL536_RS44670	COG1285	pathogenesis
AL536_RS44675	COG1509	lysine 2,3-aminomutase activity
AL536_RS44680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL536_RS44690	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL536_RS44695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL536_RS44700	COG1053	succinate dehydrogenase
AL536_RS44710	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL536_RS44715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL536_RS44720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL536_RS44725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL536_RS44730	COG1045	serine acetyltransferase
AL536_RS44735	COG1695	Transcriptional regulator
AL536_RS44740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL536_RS44745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL536_RS44750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL536_RS44755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL536_RS44760	COG0137	argininosuccinate synthase activity
AL536_RS44765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL536_RS44765	COG0165	Argininosuccinate lyase
AL536_RS44775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL536_RS44775	COG0678	peroxiredoxin activity
AL536_RS44785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL536_RS44820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL536_RS44830	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL536_RS44835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL536_RS44845	COG0180	Tryptophanyl-tRNA synthetase
AL536_RS44855	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL536_RS44865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL536_RS44875	COG1012	belongs to the aldehyde dehydrogenase family
AL536_RS44890	COG3954	Phosphoribulokinase
AL536_RS44900	COG0429	hydrolase of the alpha beta-hydrolase fold
AL536_RS44910	COG0488	(ABC) transporter
AL536_RS44915	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL536_RS44925	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AL536_RS44930	COG1047	Peptidyl-prolyl cis-trans
AL536_RS44940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL536_RS44945	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL536_RS44950	COG3083	sulfuric ester hydrolase activity
AL536_RS44955	COG0557	exoribonuclease II activity
AL536_RS44960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL536_RS44965	COG0051	transcription antitermination factor activity, RNA binding
AL536_RS44970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL536_RS44975	COG0088	Forms part of the polypeptide exit tunnel
AL536_RS44980	COG0089	rRNA binding
AL536_RS44985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL536_RS44990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL536_RS44995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL536_RS45005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL536_RS45010	COG0255	Belongs to the universal ribosomal protein uL29 family
AL536_RS45015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL536_RS45020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL536_RS45025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL536_RS45030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL536_RS45035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL536_RS45040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL536_RS45050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL536_RS45060	COG1841	ribosomal large subunit assembly
AL536_RS45065	COG0200	Binds to the 23S rRNA
AL536_RS45070	COG0201	protein transport
AL536_RS45075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL536_RS45080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL536_RS45085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL536_RS45090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL536_RS45095	COG0202	RNA polymerase activity
AL536_RS45100	COG0203	ribosomal protein L17
AL536_RS45110	COG0545	Peptidyl-prolyl cis-trans isomerase
AL536_RS45115	COG3061	Opacity-associated protein A
AL536_RS45120	COG0697	spore germination
AL536_RS45125	COG2153	protein acetylation
AL536_RS45130	COG0513	Belongs to the DEAD box helicase family
AL536_RS45140	COG0737	Belongs to the 5'-nucleotidase family
AL536_RS45145	COG1648	precorrin-2 dehydrogenase activity
AL536_RS45145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL536_RS45150	COG0175	sulfate reduction
AL536_RS45155	COG2895	sulfate adenylyltransferase (ATP) activity
AL536_RS45160	COG0471	metal ion transport
AL536_RS45160	COG0490	domain, Protein
AL536_RS45165	COG0529	Catalyzes the synthesis of activated sulfate
AL536_RS45185	COG1136	(ABC) transporter
AL536_RS45185	COG0577	efflux transmembrane transporter activity
AL536_RS45200	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL536_RS45205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL536_RS45210	COG0729	surface antigen
AL536_RS45220	COG2105	PFAM AIG2 family protein
AL536_RS45225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL536_RS45230	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL536_RS45235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL536_RS45240	COG0163	prenyltransferase activity
AL536_RS45250	COG1178	ABC-type Fe3 transport system permease component
AL536_RS45255	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL536_RS45260	COG3028	Belongs to the UPF0307 family
AL536_RS45265	COG0312	modulator of DNA gyrase
AL536_RS45270	COG2239	Acts as a magnesium transporter
AL536_RS45275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL536_RS45280	COG1660	Displays ATPase and GTPase activities
AL536_RS45285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL536_RS45290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL536_RS45300	COG1137	ATPase activity
AL536_RS45305	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL536_RS45315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AL536_RS45320	COG0517	IMP dehydrogenase activity
AL536_RS45320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL536_RS45330	COG1127	ABC transporter
AL536_RS45335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL536_RS45340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL536_RS45345	COG2854	intermembrane phospholipid transfer
AL536_RS45350	COG3113	response to antibiotic
AL536_RS45355	COG5007	Belongs to the BolA IbaG family
AL536_RS45360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine