locus-tag class description GO176_RS00010 ENOG4105WEM extracellular solute-binding protein GO176_RS00015 ENOG4108IJ9 (ABC) transporter GO176_RS00020 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GO176_RS00025 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GO176_RS00040 ENOG4108N3W hemolysin secretion protein GO176_RS00050 ENOG4108UHU Aldolase GO176_RS00055 ENOG4107SS6 2-dehydro-3-deoxygluconokinase GO176_RS00065 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) GO176_RS00070 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GO176_RS00075 ENOG4105DKG l-rhamnose isomerase GO176_RS00080 ENOG4105DET Rhamnulokinase GO176_RS00085 ENOG4105F5H Glycosyl Hydrolase Family 88 GO176_RS00090 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS00100 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GO176_RS00115 ENOG4105M5J Cupin 2, conserved barrel domain protein GO176_RS00120 ENOG4105P66 Membrane GO176_RS00125 ENOG4105CHR reductase GO176_RS00135 ENOG41080XP Cbs domain GO176_RS00155 ENOG4108HK0 -acetyltransferase GO176_RS00165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GO176_RS00175 ENOG4105P8Q Curli production assembly transport component CsgG GO176_RS00180 ENOG4108WYR Curli production assembly transport component, CsgF GO176_RS00205 ENOG4108IJ9 (ABC) transporter GO176_RS00210 ENOG4107FKK extracellular solute-binding protein family 1 GO176_RS00215 ENOG4105D56 permease protein GO176_RS00220 ENOG4105EG2 ABC transporter, permease GO176_RS00235 ENOG4105NNS Autoinducer synthesis protein GO176_RS00240 ENOG4105VJY transcriptional regulator GO176_RS00245 ENOG4105E98 transcriptional regulator DeoR family GO176_RS00265 ENOG4105CKW Inner membrane protein yedI GO176_RS00270 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GO176_RS00275 ENOG4105EKE dihydroorotase GO176_RS00280 ENOG4105QVC MOSC domain-containing protein GO176_RS00310 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GO176_RS00315 ENOG4105EHG Permease protein GO176_RS00325 ENOG4106GFD transport protein GO176_RS00330 ENOG41090AP transport protein GO176_RS00335 ENOG4105WQ5 TonB family GO176_RS00340 ENOG4105D4P Coproporphyrinogen iii oxidase GO176_RS00345 ENOG41090JE Utilization Protein GO176_RS00350 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related GO176_RS00355 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS00365 ENOG4108XM1 transcriptional regulator AsnC family GO176_RS00385 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GO176_RS00390 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GO176_RS00395 ENOG4108M8H domain protein GO176_RS00420 ENOG4105BZU Histidine kinase GO176_RS00425 ENOG4105BZU Histidine kinase GO176_RS00440 ENOG4108UKZ OsmC family GO176_RS00450 ENOG4108UW5 maltose o-acetyltransferase GO176_RS00470 ENOG4105CW0 outer membrane usher protein GO176_RS00480 ENOG4105GQR Chaperone GO176_RS00485 ENOG4105D5U fad dependent oxidoreductase GO176_RS00505 ENOG4105DND Transcriptional regulator GO176_RS00510 ENOG4105D6J arsenicaL-resistance protein GO176_RS00515 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GO176_RS00520 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GO176_RS00525 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GO176_RS00530 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GO176_RS00535 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GO176_RS00540 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GO176_RS00545 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GO176_RS00550 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GO176_RS00570 ENOG4107QWG 2-Nitropropane dioxygenase GO176_RS00580 ENOG4105C1J atp-dependent rna helicase GO176_RS00585 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS00590 ENOG4106AFQ Histidine kinase GO176_RS00595 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS00615 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GO176_RS00620 ENOG4108UQV Membrane GO176_RS00640 ENOG4105D0C transport protein GO176_RS00650 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GO176_RS00695 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GO176_RS00700 ENOG4105HDD phospholipase GO176_RS00710 ENOG4105C94 Transporter GO176_RS00715 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GO176_RS00720 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GO176_RS00725 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GO176_RS00735 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GO176_RS00745 ENOG4105BZU Histidine kinase GO176_RS00750 ENOG4105BZU Histidine kinase GO176_RS00755 ENOG4107RE1 Inosine-guanosine kinase GO176_RS00810 ENOG4105RKW reductase (By GO176_RS00820 ENOG4108I0Y (ABC) transporter GO176_RS00825 ENOG4105CV6 ABC transporter, permease GO176_RS00835 ENOG4107R7A Allophanate hydrolase subunit 2 GO176_RS00845 ENOG4105E7W lamb ycsf family protein GO176_RS00855 ENOG4105CMR udp-glucose 4-epimerase GO176_RS00860 ENOG4108N3W hemolysin secretion protein GO176_RS00865 ENOG4105E0U tyrosine-specific transport protein GO176_RS00870 ENOG4108ZYK Acyl carrier protein phosphodiesterase GO176_RS00875 ENOG4105C1J atp-dependent rna helicase GO176_RS00880 ENOG4108IG5 Transcriptional regulator GO176_RS00885 ENOG4106RE7 Cytochrome GO176_RS00890 ENOG4105C5W Aldolase GO176_RS00905 ENOG4105EV2 VWA domain protein interacting with AAA ATPase GO176_RS00935 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS00940 ENOG4108RS6 transposase GO176_RS00955 ENOG410642W LysR family Transcriptional regulator GO176_RS00960 ENOG4108IPJ Membrane GO176_RS00985 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GO176_RS01000 ENOG4105CVJ phosphoglycerate mutase GO176_RS01005 ENOG4105DHT Metal Dependent Phosphohydrolase GO176_RS01010 ENOG4105C0A alcohol dehydrogenase GO176_RS01015 ENOG4105T16 Transcriptional regulator (AraC family) GO176_RS01020 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GO176_RS01030 ENOG4108JU3 Alkyl hydroperoxide reductase GO176_RS01035 ENOG4105D3R alkyl hydroperoxide reductase GO176_RS01045 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GO176_RS01050 ENOG4108IPT Naphthoate synthase GO176_RS01055 ENOG4107QX3 carboxylase GO176_RS01060 ENOG4105C1G acyl-Coa dehydrogenase GO176_RS01070 ENOG4105CHU acetyl-coa acetyltransferase GO176_RS01075 ENOG4105C26 Dehydrogenase GO176_RS01080 ENOG4105C1G acyl-Coa dehydrogenase GO176_RS01085 ENOG4105E39 Enoyl-CoA hydratase GO176_RS01090 ENOG4105E39 Enoyl-CoA hydratase GO176_RS01095 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GO176_RS01100 ENOG4105CHR reductase GO176_RS01110 ENOG4105CHR reductase GO176_RS01125 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GO176_RS01130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS01140 ENOG4105CH5 extracellular solute-binding protein, family 7 GO176_RS01170 ENOG4105D01 (LipO)protein GO176_RS01190 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GO176_RS01195 ENOG4105C8U phosphate abc transporter GO176_RS01205 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GO176_RS01210 ENOG4105CYM Glutathione S-transferase GO176_RS01215 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GO176_RS01220 ENOG4105BZJ Electron transfer flavoprotein GO176_RS01235 ENOG4107QSN dihydrolipoamide acetyltransferase GO176_RS01255 ENOG4105BZU Histidine kinase GO176_RS01275 ENOG4105CTX dehydratase GO176_RS01285 ENOG4105D2H Uronic isomerase GO176_RS01290 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter GO176_RS01295 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS01300 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GO176_RS01310 ENOG4105EHG Permease protein GO176_RS01315 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GO176_RS01325 ENOG4108MGI Transcriptional regulator GO176_RS01330 ENOG4105CH2 amidohydrolase GO176_RS01345 ENOG4108NIW Leucine export protein LeuE GO176_RS01355 ENOG4105CHF Glutathione S-transferase GO176_RS01360 ENOG4105CC0 LysR family Transcriptional regulator GO176_RS01365 ENOG4108IA2 Sodium pantothenate symporter GO176_RS01375 ENOG4105CIF Ornithine Cyclodeaminase GO176_RS01380 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS01390 ENOG4105CH5 extracellular solute-binding protein, family 7 GO176_RS01395 ENOG4105II7 pyrroline-5-carboxylate reductase GO176_RS01425 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GO176_RS01445 ENOG4108I1J Integrase GO176_RS01470 ENOG4105DH7 May be involved in recombination (By similarity) GO176_RS01590 ENOG4106CVF DNA replication protein GO176_RS01625 ENOG4105RWQ Protein of unknown function (DUF1364) GO176_RS01640 ENOG4105KUS lysozyme GO176_RS01650 ENOG4108TFU terminase (Small subunit) GO176_RS01790 ENOG4105CF7 AraC family transcriptional regulator GO176_RS01810 ENOG4105C87 Aminotransferase class I and II GO176_RS01820 ENOG4105C5H ABC transporter GO176_RS02035 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GO176_RS02125 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GO176_RS02175 ENOG4105SB3 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GO176_RS02180 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GO176_RS02185 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GO176_RS02195 ENOG4108UGV hypoxanthine phosphoribosyltransferase GO176_RS02200 ENOG4108UW5 maltose o-acetyltransferase GO176_RS02215 ENOG4105DY2 Paraquat-inducible protein b GO176_RS02230 ENOG4105EVZ LysR family transcriptional regulator GO176_RS02240 ENOG4108ERU trap dicarboxylate transporter subunit DctP GO176_RS02250 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS02260 ENOG4108JPW Aminotransferase GO176_RS02270 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GO176_RS02285 ENOG4105CVA phosphate GO176_RS02295 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GO176_RS02300 ENOG4105C1J atp-dependent rna helicase GO176_RS02305 ENOG4105C22 threonyL-tRNA synthetase GO176_RS02310 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GO176_RS02315 ENOG41082NX 50s ribosomal protein l35 GO176_RS02320 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GO176_RS02330 ENOG4105WP5 GO176_RS02335 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GO176_RS02375 ENOG4105VUF Transcriptional regulator GO176_RS02380 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GO176_RS02390 ENOG4108594 Permease of the drug metabolite transporter GO176_RS02410 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) GO176_RS02435 ENOG4105I4A GCN5-related N-acetyltransferase GO176_RS02445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GO176_RS02455 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GO176_RS02480 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GO176_RS02485 ENOG4105RA2 Membrane GO176_RS02490 ENOG4105M6F mutator MutT protein GO176_RS02495 ENOG4105N14 lysine exporter protein LysE YggA GO176_RS02505 ENOG4105KD7 acetyltransferase GO176_RS02515 ENOG4108RWI nicotinamidase GO176_RS02530 ENOG4108VP3 Lysine exporter protein (LysE YggA) GO176_RS02545 ENOG4108JQ1 Dehydrogenase GO176_RS02550 ENOG4105J7D transcriptional regulator GO176_RS02560 ENOG4108WAV Transcriptional regulator GO176_RS02570 ENOG4105CV1 Transketolase (EC 2.2.1.1) GO176_RS02575 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GO176_RS02585 ENOG4105KHC sulfurtransferase GO176_RS02590 ENOG4105D06 uba thif-type nad fad binding protein GO176_RS02595 ENOG4105CVM Molybdenum cofactor synthesis domain protein GO176_RS02605 ENOG4105CUB amino acid GO176_RS02620 ENOG4108K3Z AraC family transcriptional regulator GO176_RS02625 ENOG4105E0X reductase GO176_RS02635 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GO176_RS02645 ENOG4105JQN Transcriptional regulator GO176_RS02655 ENOG4105NXH GreA GreB family elongation factor GO176_RS02665 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GO176_RS02690 ENOG4107RCV ABC transporter, permease GO176_RS02730 ENOG4105E43 Extracellular solute-binding protein, family 5 GO176_RS02735 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GO176_RS02745 ENOG4108JQ5 ABC transporter GO176_RS02750 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GO176_RS02775 ENOG4108Q9V regulatoR GO176_RS02780 ENOG4108KHP Diguanylate cyclase GO176_RS02795 ENOG4105WQ3 Rna-binding protein GO176_RS02800 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS02805 ENOG4105CWM branched-chain amino acid transport system II carrier protein GO176_RS02820 ENOG4105F2V VRR-NUC domain-containing protein GO176_RS02845 ENOG4105ENX hydrolase GO176_RS02850 ENOG4108TU9 TRANSCRIPTIONal GO176_RS02880 ENOG4108RS6 transposase GO176_RS02890 ENOG410874W AraC family transcriptional regulator GO176_RS02895 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GO176_RS02900 ENOG4105C2W permease GO176_RS02910 ENOG410633P Hydantoin racemase GO176_RS02920 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GO176_RS02930 ENOG4105DRP amino acid AbC transporter GO176_RS02935 ENOG4105E5Q amino acid AbC transporter GO176_RS02950 ENOG4105DHU Bile acid GO176_RS02960 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GO176_RS02965 ENOG4105C5R Aminotransferase GO176_RS02985 ENOG4107QUY Guanine deaminase GO176_RS02990 ENOG4105VT2 5-hydroxyisourate hydrolase GO176_RS03025 ENOG4105UIB (ABC) transporter GO176_RS03030 ENOG4105C2J ABC transporter GO176_RS03035 ENOG4108R86 Transcriptional regulator GO176_RS03045 ENOG4106TD9 Diguanylate cyclase GO176_RS03055 ENOG41064RH membrane protein YliF GO176_RS03075 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GO176_RS03110 ENOG4108ZJT translation initiation factor, Sui1 GO176_RS03125 ENOG4105CPF Cell wall formation (By similarity) GO176_RS03135 ENOG4105CD5 CoA-binding domain protein GO176_RS03140 ENOG4105CWB LysR family transcriptional Regulator GO176_RS03155 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GO176_RS03165 ENOG4105KA0 thioesterase Superfamily protein GO176_RS03170 ENOG4105ERG peptidase m48, ste24p GO176_RS03175 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GO176_RS03190 ENOG4105CGH 5'-nucleotidase GO176_RS03195 ENOG4105CPB ATP-dependent endonuclease of the OLD family GO176_RS03200 ENOG4108UQ5 membrane protein YcdZ GO176_RS03205 ENOG4105DUM transcriptional regulator, lysR family GO176_RS03210 ENOG4105TMB Formate nitrite transporter GO176_RS03215 ENOG4108YYC ycei family GO176_RS03220 ENOG4105DS1 cytochrome b561 GO176_RS03245 ENOG4105BZU Histidine kinase GO176_RS03255 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GO176_RS03260 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GO176_RS03270 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GO176_RS03280 ENOG4105R1U AraC Family Transcriptional Regulator GO176_RS03285 ENOG4105DQ4 alcohol dehydrogenase GO176_RS03290 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GO176_RS03295 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GO176_RS03300 ENOG4105DFP Integrase GO176_RS03315 ENOG4108SAU DNA-binding protein H-ns GO176_RS03320 ENOG4105BZU Histidine kinase GO176_RS03325 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS03355 ENOG41061ZR Transcriptional regulator GO176_RS03375 ENOG4105R3A Nitrate reductase GO176_RS03380 ENOG4108IUE nitrate reductase beta subunit GO176_RS03390 ENOG4105DQQ Major facilitator superfamily MFS_1 GO176_RS03395 ENOG4105BZU Histidine kinase GO176_RS03400 ENOG4105WH1 Two component transcriptional regulator luxr family GO176_RS03405 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GO176_RS03410 ENOG4105CJW magnesium transporter GO176_RS03415 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS03435 ENOG4108JUA Transcriptional regulator GO176_RS03455 ENOG4105ENG CRISPR-associated protein, Csy1 family GO176_RS03465 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GO176_RS03480 ENOG4105ETE Transcriptional regulator (LacI family GO176_RS03490 ENOG4107WI4 Aldose-1-epimerase GO176_RS03495 ENOG4105E2V Glycosyltransferase 36 GO176_RS03500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO176_RS03510 ENOG4105DRS transport system, permease GO176_RS03525 ENOG41060NJ transcriptional regulator GO176_RS03530 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS03540 ENOG4105UQX Mate efflux family protein GO176_RS03545 ENOG4105ECQ AraC Family Transcriptional Regulator GO176_RS03555 ENOG4108YGG dna repair protein GO176_RS03585 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GO176_RS03605 ENOG4108RVA ribokinase GO176_RS03630 ENOG4105F8D glycoside hydrolase family 4 GO176_RS03635 ENOG4105ETT transcriptional Regulator, LysR family GO176_RS03640 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GO176_RS03645 ENOG4105CKI cobalamin synthesis protein GO176_RS03650 ENOG4108RS6 transposase GO176_RS03655 ENOG4105CMQ Chloride channel GO176_RS03665 ENOG4107KBT 8-Amino-7-oxononanoate synthase GO176_RS03670 ENOG4108MGY Histidine kinase GO176_RS03675 ENOG4105EYH Exonuclease GO176_RS03680 ENOG4107RFY SbcCD D subunit GO176_RS03685 ENOG4107B7Y DNA-binding transcriptional regulator FruR GO176_RS03690 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GO176_RS03695 ENOG4105DE4 1-phosphofructokinase GO176_RS03700 ENOG4105DM4 PTS System GO176_RS03705 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GO176_RS03710 ENOG4105CGF Aromatic amino acid aminotransferase GO176_RS03715 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GO176_RS03720 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GO176_RS03775 ENOG4105ENX hydrolase GO176_RS03780 ENOG4105EQ2 LysR family Transcriptional regulator GO176_RS03785 ENOG4108HYG acetyltransferase GO176_RS03790 ENOG4105CF7 AraC family transcriptional regulator GO176_RS03800 ENOG4105ENX hydrolase GO176_RS03805 ENOG4105ENX hydrolase GO176_RS03810 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GO176_RS03815 ENOG4105EMU Dehydrogenase GO176_RS03830 ENOG4105EQ2 LysR family Transcriptional regulator GO176_RS03850 ENOG4105Y49 secretion protein, HlyD family GO176_RS03855 ENOG4105ETT transcriptional Regulator, LysR family GO176_RS03860 ENOG4105N14 lysine exporter protein LysE YggA GO176_RS03865 ENOG4108KXV response regulator GO176_RS03875 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GO176_RS03880 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GO176_RS03885 ENOG4105CDV Ompa motb domain protein GO176_RS03895 ENOG4108V1T peptidylprolyl cis-trans isomerase GO176_RS03905 ENOG4108N3W hemolysin secretion protein GO176_RS03910 ENOG4105DXI Major Facilitator superfamily GO176_RS03925 ENOG4105CEE C4-dicarboxylate transporter GO176_RS03930 ENOG4105WH1 Two component transcriptional regulator luxr family GO176_RS03950 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GO176_RS03970 ENOG4107QSI ABC, transporter GO176_RS03980 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GO176_RS03990 ENOG4105CHU acetyl-coa acetyltransferase GO176_RS04005 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GO176_RS04025 ENOG4105BZU Histidine kinase GO176_RS04030 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GO176_RS04045 ENOG4108I6A alcohol dehydrogenase GO176_RS04055 ENOG4105BZU Histidine kinase GO176_RS04060 ENOG4108SV3 Tmao reductase system periplasmic protein tort GO176_RS04065 ENOG4108Z5K methylglyoxal synthase GO176_RS04070 ENOG4108RWI nicotinamidase GO176_RS04075 ENOG41088T4 Helicase IV GO176_RS04120 ENOG4107QZV Type I secretion membrane fusion protein GO176_RS04135 ENOG4108JJA ABC, transporter GO176_RS04140 ENOG4105EM2 membrane GO176_RS04165 ENOG4105E0C molybdate abc transporter GO176_RS04170 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GO176_RS04200 ENOG4108QGH periplasmic GO176_RS04205 ENOG41082IR Excinuclease ABC C subunit domain protein GO176_RS04220 ENOG41090HJ UPF0265 protein GO176_RS04225 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GO176_RS04250 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GO176_RS04275 ENOG4106CC8 Bacterial inner membrane protein GO176_RS04280 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GO176_RS04285 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GO176_RS04295 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B GO176_RS04300 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GO176_RS04315 ENOG4107RA4 Glycosyl transferase (Group 1 GO176_RS04320 ENOG4105CG5 Glycosyl transferase (Group 1 GO176_RS04345 ENOG4105DAY polysaccharide export protein GO176_RS04355 ENOG4105D3Q Sugar transferase GO176_RS04370 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GO176_RS04375 ENOG4105K63 Thioredoxin GO176_RS04380 ENOG4108ISG Major Facilitator GO176_RS04385 ENOG4105VXR cytoplasmic protein GO176_RS04405 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GO176_RS04415 ENOG4105WZK nitrite reductase NADPH small subunit GO176_RS04420 ENOG4107QZF nitrite reductase NADPH large subunit GO176_RS04425 ENOG4105C94 Transporter GO176_RS04430 ENOG4105DMR ABC, transporter GO176_RS04435 ENOG4105GBT ABC transporter GO176_RS04440 ENOG4106PMH Extracellular solute-binding protein family 3 GO176_RS04445 ENOG4105E5Z arginine transporter ATP-binding subunit GO176_RS04470 ENOG4105S6R Iron-hydroxamate transporter permease subunit GO176_RS04475 ENOG4105J76 Periplasmic binding protein GO176_RS04480 ENOG4105E0A ABC, transporter GO176_RS04485 ENOG4108NVR Methyl-accepting chemotaxis GO176_RS04490 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GO176_RS04495 ENOG4105HEI LysR family (Transcriptional regulator GO176_RS04500 ENOG4105C94 Transporter GO176_RS04510 ENOG4108RCM Nitroreductase GO176_RS04515 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GO176_RS04520 ENOG4105IE8 Alpha-ketoglutarate permease GO176_RS04525 ENOG4105CMG Carbohydrate kinase GO176_RS04530 ENOG4105DEI Mannitol dehydrogenase GO176_RS04535 ENOG4105DKT Transcriptional regulator GO176_RS04540 ENOG4105DZW Dipeptidase GO176_RS04545 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GO176_RS04550 ENOG4105C4M (Ubiquinol oxidase) subunit I GO176_RS04560 ENOG4105FFC UPF0187 protein GO176_RS04565 ENOG4107RSM transcriptional regulator GO176_RS04570 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GO176_RS04585 ENOG4105DEN Luciferase family GO176_RS04595 ENOG4107QX8 SPFH domain, Band 7 family protein GO176_RS04615 ENOG4106AXJ AraC family transcriptional regulator GO176_RS04620 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GO176_RS04640 ENOG4108IPW abc transporter atp-binding protein GO176_RS04645 ENOG4105CM4 permease protein GO176_RS04650 ENOG4105DHS permease protein GO176_RS04660 ENOG4108V75 Glutamine amidotransferase GO176_RS04670 ENOG4107G87 m6 family metalloprotease domain protein GO176_RS04680 ENOG4107IFA Lipase (EC 3.1.1.3) GO176_RS04685 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS04690 ENOG4108XM1 transcriptional regulator AsnC family GO176_RS04710 ENOG4105E5M Multidrug resistance protein D GO176_RS04735 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GO176_RS04740 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GO176_RS04745 ENOG4108VAC response regulator GO176_RS04750 ENOG4108HRK Histidine kinase GO176_RS04755 ENOG4107RGM aldo keto reductase GO176_RS04770 ENOG4107T9C Alpha amylase catalytic region GO176_RS04775 ENOG4105D4Y metalloprotease GO176_RS04780 ENOG4105EIF outer membrane protein W GO176_RS04815 ENOG4105EIP mannose-6-phosphate isomerase GO176_RS04820 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS04830 ENOG4105HY2 Glycosidase related protein GO176_RS04835 ENOG4105CKB glycosidase GO176_RS04845 ENOG4105DIQ Transcriptional regulator GO176_RS04855 ENOG4105DFY n-acylglucosamine 2-epimerase GO176_RS04865 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GO176_RS04870 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GO176_RS04890 ENOG4108YI8 ABC transporter GO176_RS04895 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component GO176_RS04900 ENOG4107Z6I Thiamine biosynthesis protein GO176_RS04905 ENOG4105ETU transcriptional activator (TenA GO176_RS04910 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GO176_RS04915 ENOG4105BZ1 (ABC) transporter GO176_RS04920 ENOG4105BZ1 (ABC) transporter GO176_RS04935 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase GO176_RS04955 ENOG4105VEQ Cold shock protein GO176_RS04960 ENOG4105CPQ Dehydrogenase GO176_RS04965 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GO176_RS04970 ENOG4105C26 Dehydrogenase GO176_RS04975 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GO176_RS04980 ENOG4105EXG Transcriptional regulator GO176_RS04985 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GO176_RS05000 ENOG4107SSZ Phosphatase GO176_RS05015 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GO176_RS05020 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) GO176_RS05025 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GO176_RS05035 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS05055 ENOG4105C3R Methionine synthase GO176_RS05060 ENOG4105D5Q Arginine ornithine antiporter GO176_RS05075 ENOG4105BZW Glycerate kinase GO176_RS05080 ENOG4105C6Z Gluconate GO176_RS05085 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GO176_RS05090 ENOG4105C5I Dehydrogenase GO176_RS05095 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GO176_RS05150 ENOG4108D1K outer membrane usher protein GO176_RS05155 ENOG4108MQF Chaperone GO176_RS05170 ENOG4105DSW Fusaric acid resistance protein GO176_RS05175 ENOG4105Y49 secretion protein, HlyD family GO176_RS05190 ENOG4105DZ1 carboxypeptidase GO176_RS05200 ENOG4105E5Q amino acid AbC transporter GO176_RS05220 ENOG4105CYW agmatinase GO176_RS05225 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GO176_RS05235 ENOG4108IJ7 Glycine betaine GO176_RS05240 ENOG4108HQS Glycine betaine GO176_RS05245 ENOG4105GIJ Glycine betaine GO176_RS05255 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS05265 ENOG4105CJW magnesium transporter GO176_RS05270 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GO176_RS05275 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GO176_RS05285 ENOG4105D52 delta-aminolevulinic acid dehydratase GO176_RS05290 ENOG4105BZU Histidine kinase GO176_RS05295 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GO176_RS05305 ENOG4107R11 Transcriptional regulator GO176_RS05320 ENOG4105CZK Aspartate kinase GO176_RS05325 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GO176_RS05330 ENOG4108JPW Aminotransferase GO176_RS05335 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GO176_RS05340 ENOG4105E7U AraC family transcriptional regulator GO176_RS05345 ENOG4105EE5 Membrane protein terC GO176_RS05355 ENOG4105UQX Mate efflux family protein GO176_RS05360 ENOG41090A4 Pterin carbinolamine dehydratase GO176_RS05365 ENOG4105MIR Phenylalanine 4-monooxygenase GO176_RS05380 ENOG4105DHQ Histidine kinase GO176_RS05385 ENOG4105XJC Two component transcriptional regulator (Winged helix family GO176_RS05395 ENOG4105CHR reductase GO176_RS05415 ENOG4105EGI Transcriptional regulator GO176_RS05425 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GO176_RS05435 ENOG4105C5I Dehydrogenase GO176_RS05440 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GO176_RS05450 ENOG4108WQH regulatoR GO176_RS05460 ENOG4105BZU Histidine kinase GO176_RS05470 ENOG4105EFQ Two component transcriptional regulator (Winged helix family GO176_RS05495 ENOG4105VEQ Cold shock protein GO176_RS05500 ENOG4108VWS Yaeq family GO176_RS05505 ENOG4105BZU Histidine kinase GO176_RS05515 ENOG4108JUA Transcriptional regulator GO176_RS05525 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GO176_RS05560 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GO176_RS05580 ENOG4107QVM von Willebrand factor, type A GO176_RS05595 ENOG4108K0B C-di-gmp phosphodiesterase GO176_RS05620 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) GO176_RS05625 ENOG4105C26 Dehydrogenase GO176_RS05635 ENOG4108T2Z Arginine GO176_RS05645 ENOG4105ECQ AraC Family Transcriptional Regulator GO176_RS05650 ENOG4107S8C mandelate racemase muconate lactonizing GO176_RS05675 ENOG4105DUM transcriptional regulator, lysR family GO176_RS05700 ENOG41090ED Protein with unknown function (DUF469) GO176_RS05705 ENOG4108M6U Universal stress protein A GO176_RS05710 ENOG4108YZN class I peptide chain release factor GO176_RS05715 ENOG4105VRT cytoplasmic protein GO176_RS05725 ENOG4105D5U fad dependent oxidoreductase GO176_RS05745 ENOG41086KC Transcriptional regulator GO176_RS05755 ENOG4105DTR rard protein GO176_RS05770 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GO176_RS05780 ENOG41089BK Glutamine amido-transferase GO176_RS05785 ENOG4105E7U AraC family transcriptional regulator GO176_RS05790 ENOG4105KME endoribonuclease L-psp GO176_RS05820 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GO176_RS05825 ENOG4107R88 Chemotaxis protein (CheV) GO176_RS05830 ENOG4105MSB protein, conserved in bacteria GO176_RS05845 ENOG4106TD9 Diguanylate cyclase GO176_RS05865 ENOG4105BZU Histidine kinase GO176_RS05890 ENOG4105BZU Histidine kinase GO176_RS05900 ENOG4105EUB pirin domain protein GO176_RS05905 ENOG4105E3W Two component transcriptional regulator (Winged helix family GO176_RS05950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GO176_RS06010 ENOG4105CS6 Rhs element vgr protein GO176_RS06030 ENOG4105NBK UPF0345 protein GO176_RS06045 ENOG4107ZYR domain protein GO176_RS06050 ENOG4105D64 Mechanosensitive ion channel GO176_RS06055 ENOG4105E5W Transporter GO176_RS06060 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS06065 ENOG4105DAN ATP-dependent protease GO176_RS06075 ENOG4108JQ5 ABC transporter GO176_RS06080 ENOG4105CC0 LysR family Transcriptional regulator GO176_RS06085 ENOG4105DAA L-lactate GO176_RS06090 ENOG4105DMF Dehydrogenase GO176_RS06100 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GO176_RS06115 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GO176_RS06135 ENOG4105KAF membrAne GO176_RS06150 ENOG4105N1F Hnh endonuclease GO176_RS06160 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GO176_RS06165 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GO176_RS06180 ENOG4105CBN LysR family transcriptional regulator GO176_RS06190 ENOG4105E0A ABC, transporter GO176_RS06195 ENOG4108IHU transport system permease protein GO176_RS06200 ENOG4105DQ5 transport system permease protein GO176_RS06205 ENOG4108HUF Transporter GO176_RS06210 ENOG4108ESX Receptor GO176_RS06225 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GO176_RS06230 ENOG4105CC0 LysR family Transcriptional regulator GO176_RS06240 ENOG4105VYW UPF0251 protein GO176_RS06250 ENOG4105CIH Imidazole acetol-phosphate transaminase GO176_RS06255 ENOG4105E89 ABC transporter GO176_RS06265 ENOG4105J12 Multidrug resistance protein mdtN GO176_RS06285 ENOG4105EZV Transcriptional regulator GO176_RS06290 ENOG4105CK2 sodium dicarboxylate symporter GO176_RS06295 ENOG4105DN9 Na H antiporter GO176_RS06300 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GO176_RS06305 ENOG4105D03 DNA-3-methyladenine glycosylase II GO176_RS06310 ENOG4108VGI doxx family GO176_RS06315 ENOG4105DZC cytosine deaminase GO176_RS06340 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GO176_RS06355 ENOG4105DR5 peptidase GO176_RS06360 ENOG4105CTS PTS system mannitol-specific GO176_RS06365 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GO176_RS06370 ENOG4105E61 Mannitol repressor protein GO176_RS06375 ENOG4105EP9 oxidoreductase GO176_RS06380 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GO176_RS06390 ENOG4108UTZ Dihydroxyacetone kinase GO176_RS06395 ENOG4105CMT Dihydroxyacetone kinase GO176_RS06415 ENOG4105CFC Transporter GO176_RS06435 ENOG4108NEM leader-binding protein dmsD GO176_RS06440 ENOG4107KGK dmso reductase anchor subunit GO176_RS06445 ENOG4105QAX Iron-sulfur GO176_RS06450 ENOG4107QY8 reductase GO176_RS06455 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) GO176_RS06460 ENOG4105R8A Heat shock protein GO176_RS06480 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GO176_RS06500 ENOG4105CC0 LysR family Transcriptional regulator GO176_RS06520 ENOG4105FKQ transcriptional regulator GO176_RS06525 ENOG4107QNK )-transporter GO176_RS06535 ENOG4105EMU Dehydrogenase GO176_RS06540 ENOG4105CC0 LysR family Transcriptional regulator GO176_RS06555 ENOG4105BZU Histidine kinase GO176_RS06560 ENOG4107SQD Transcriptional regulator, GntR family GO176_RS06570 ENOG410901E Membrane GO176_RS06575 ENOG41061CK Antibiotic biosynthesis monooxygenase GO176_RS06590 ENOG4105T16 Transcriptional regulator (AraC family) GO176_RS06595 ENOG4108W2Y isochorismatase GO176_RS06605 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) GO176_RS06625 ENOG4107SDU Methyl-accepting chemotaxis GO176_RS06630 ENOG4105MVE transcriptional regulator GO176_RS06635 ENOG4105ZXK Dehydrogenase GO176_RS06640 ENOG4105G63 Type III effector Hrp-dependent GO176_RS06645 ENOG4105FB2 class II Aldolase GO176_RS06650 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GO176_RS06655 ENOG4105EXW epimerase dehydratase GO176_RS06660 ENOG4105C6Z Gluconate GO176_RS06665 ENOG4108ZRZ Transcriptional regulator (AsnC family) GO176_RS06670 ENOG4105C9B Cysteine desulfurase GO176_RS06675 ENOG4105VFU Rna-binding protein GO176_RS06680 ENOG4108Z6Z Transcriptional regulator GO176_RS06695 ENOG4105DDR sarcosine oxidase (Beta subunit) GO176_RS06715 ENOG4105DMQ Methyltransferase GO176_RS06720 ENOG4105ETT transcriptional Regulator, LysR family GO176_RS06730 ENOG4105C1J atp-dependent rna helicase GO176_RS06740 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GO176_RS06745 ENOG4107RGH Aldehyde dehydrogenase GO176_RS06750 ENOG4105EW9 transcriptional regulator AsnC family GO176_RS06755 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS06765 ENOG4105CK7 Sodium proline symporter GO176_RS06775 ENOG4105C26 Dehydrogenase GO176_RS06790 ENOG4105E6M Sulphatase-modifying factor protein GO176_RS06800 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GO176_RS06820 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS06830 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GO176_RS06835 ENOG4105BZU Histidine kinase GO176_RS06840 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS06845 ENOG4108V3W Chemotaxis protein, CheW GO176_RS06855 ENOG4105CBS Chea signal transduction histidine kinase GO176_RS06860 ENOG4108VYJ response regulator receiver protein GO176_RS06870 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GO176_RS06875 ENOG4107RUE extracellular solute-binding protein family 1 GO176_RS06905 ENOG4105CDY transcriptional regulatory protein GO176_RS06915 ENOG4105JQN Transcriptional regulator GO176_RS06935 ENOG4105E2S oxidase) subunit II GO176_RS06940 ENOG4105BZ9 Cytochrome C oxidase, subunit I GO176_RS06945 ENOG4105CCU oxidase (Subunit III) GO176_RS06950 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GO176_RS06955 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GO176_RS06960 ENOG4108YYI Protein of unknown function (DUF2810) GO176_RS06970 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GO176_RS06975 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GO176_RS06985 ENOG4108WC9 type VI secretion system effector, hcp1 family GO176_RS06990 ENOG4105CS6 Rhs element vgr protein GO176_RS07010 ENOG4105WJG Glutathione GO176_RS07035 ENOG4105C8P )-transporter GO176_RS07040 ENOG4105D9U N-acetyltransferase GO176_RS07045 ENOG4105DHT Metal Dependent Phosphohydrolase GO176_RS07050 ENOG4108Q67 UPF0319 protein GO176_RS07055 ENOG4105C0F tryptophanase EC 4.1.99.1 GO176_RS07065 ENOG4105FDP GntR family transcriptional regulator GO176_RS07070 ENOG4105CZV ABC transporter GO176_RS07095 ENOG4108IEG Formate dehydrogenase Alpha subunit GO176_RS07115 ENOG4105BZ1 (ABC) transporter GO176_RS07125 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GO176_RS07130 ENOG4107W52 maltose operon periplasmic protein GO176_RS07140 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GO176_RS07145 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GO176_RS07170 ENOG4105D6U Sodium Glutamate Symporter GO176_RS07175 ENOG4105YE1 PilZ domain GO176_RS07205 ENOG4105EFX secretion protein, HlyD family GO176_RS07210 ENOG4105KK7 inner membrane protein YiaW GO176_RS07215 ENOG4106TD9 Diguanylate cyclase GO176_RS07230 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GO176_RS07235 ENOG4107SEY Conserved Protein GO176_RS07295 ENOG4105C1J atp-dependent rna helicase GO176_RS07300 ENOG4108NVR Methyl-accepting chemotaxis GO176_RS07305 ENOG4105CVA phosphate GO176_RS07310 ENOG4105C8U phosphate abc transporter GO176_RS07315 ENOG4105E2Z phosphate ABC transporter (Permease GO176_RS07320 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GO176_RS07325 ENOG4108KHX Diguanylate cyclase GO176_RS07335 ENOG4105DWD nucleoside recognition domain protein GO176_RS07340 ENOG4105CHH sulfate transporter GO176_RS07355 ENOG4105DR5 peptidase GO176_RS07365 ENOG4105EQ2 LysR family Transcriptional regulator GO176_RS07380 ENOG4105VW4 glutaredoxin 3 GO176_RS07385 ENOG4105FCK Membrane GO176_RS07390 ENOG4108ZHJ Organic hydroperoxide resistance protein GO176_RS07395 ENOG4105K56 Transcriptional regulator GO176_RS07400 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GO176_RS07430 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GO176_RS07435 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GO176_RS07445 ENOG4105BZ9 Cytochrome C oxidase, subunit I GO176_RS07455 ENOG4107QS1 Cytochrome C Oxidase, Subunit III GO176_RS07475 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GO176_RS07480 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GO176_RS07495 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GO176_RS07505 ENOG4105BZU Histidine kinase GO176_RS07525 ENOG4106HBX Transcriptional Regulator AraC Family GO176_RS07530 ENOG4105JAB phenazine biosynthesis protein, phzf family GO176_RS07540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GO176_RS07545 ENOG4108594 Permease of the drug metabolite transporter GO176_RS07550 ENOG4105R3P Inner membrane protein yagU GO176_RS07555 ENOG4105KUU lipolytic protein G-D-S-L family GO176_RS07560 ENOG4106M3D hemolysin GO176_RS07575 ENOG4107RH7 Nicotinate phosphoribosyltransferase GO176_RS07580 ENOG4105C94 Transporter GO176_RS07585 ENOG4105E98 transcriptional regulator DeoR family GO176_RS07590 ENOG4105D9R oxidoreductase GO176_RS07595 ENOG41090KN UPF0303 protein GO176_RS07600 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS07620 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GO176_RS07640 ENOG4105F27 Major Facilitator GO176_RS07645 ENOG4105HEI LysR family (Transcriptional regulator GO176_RS07650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GO176_RS07655 ENOG4105CV8 reductase GO176_RS07660 ENOG4105BZU Histidine kinase GO176_RS07670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO176_RS07690 ENOG4105CY5 solute-binding protein GO176_RS07700 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GO176_RS07715 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GO176_RS07720 ENOG4108WUH Transcriptional regulator, TetR family GO176_RS07725 ENOG4105D3G Pseudouridine synthase GO176_RS07740 ENOG4108ZT1 Transcriptional regulator GO176_RS07745 ENOG4108VP3 Lysine exporter protein (LysE YggA) GO176_RS07750 ENOG4105EW9 transcriptional regulator AsnC family GO176_RS07810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GO176_RS07815 ENOG4108JUB Transcriptional regulator GO176_RS07840 ENOG4105CS6 Rhs element vgr protein GO176_RS07860 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GO176_RS07865 ENOG4105C2J ABC transporter GO176_RS07870 ENOG4105CNN ABC, transporter GO176_RS07875 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GO176_RS07880 ENOG4108RVA ribokinase GO176_RS07885 ENOG4105ETE Transcriptional regulator (LacI family GO176_RS07890 ENOG4107RSM transcriptional regulator GO176_RS07895 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) GO176_RS07900 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GO176_RS07905 ENOG4105CXY transporter GO176_RS07910 ENOG4105BZU Histidine kinase GO176_RS07930 ENOG4108RS6 transposase GO176_RS07935 ENOG4105CQZ Histidine kinase GO176_RS07940 ENOG4105FDP GntR family transcriptional regulator GO176_RS07945 ENOG4105DM4 PTS System GO176_RS07950 ENOG4105C8I hydrolase, family 38 GO176_RS07955 ENOG4105BZW Glycerate kinase GO176_RS07960 ENOG4105EIP mannose-6-phosphate isomerase GO176_RS07965 ENOG4105K8R UPF0145 protein GO176_RS07970 ENOG4105CAZ oligogalacturonide lyase GO176_RS07980 ENOG4105UQX Mate efflux family protein GO176_RS07985 ENOG4105QD6 exported protein GO176_RS07995 ENOG4105D1U peptidase U62 modulator of DNA gyrase GO176_RS08015 ENOG41081QV Universal stress protein GO176_RS08030 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GO176_RS08040 ENOG4105D5Q Arginine ornithine antiporter GO176_RS08045 ENOG4105EAH synthase GO176_RS08050 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GO176_RS08055 ENOG4105K46 50S ribosomal protein l27 GO176_RS08060 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GO176_RS08065 ENOG4105DWK Membrane GO176_RS08080 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GO176_RS08085 ENOG4105NWN ApaG protein GO176_RS08090 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GO176_RS08095 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GO176_RS08100 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GO176_RS08105 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GO176_RS08110 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GO176_RS08160 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GO176_RS08165 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GO176_RS08175 ENOG4105S10 periplasmic binding protein GO176_RS08185 ENOG4108W0P ABC transporter GO176_RS08190 ENOG4105CEN a g-specific adenine glycosylase GO176_RS08195 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GO176_RS08200 ENOG4105CSV Glutaminase GO176_RS08205 ENOG4105CSA Coproporphyrinogen iii oxidase GO176_RS08210 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GO176_RS08220 ENOG4105VZ9 UPF0235 protein GO176_RS08230 ENOG4105II7 pyrroline-5-carboxylate reductase GO176_RS08235 ENOG4105DFA alanine racemase domain protein GO176_RS08240 ENOG4105CZX twitching motility protein GO176_RS08245 ENOG4105CZX twitching motility protein GO176_RS08250 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GO176_RS08255 ENOG4108UJU UPF0301 protein GO176_RS08260 ENOG4105D7Z glutathione synthase GO176_RS08265 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GO176_RS08270 ENOG4105RWS endonuclease I GO176_RS08275 ENOG4105GPY SprT protein GO176_RS08285 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GO176_RS08290 ENOG4105CV1 Transketolase (EC 2.2.1.1) GO176_RS08295 ENOG4108RS6 transposase GO176_RS08300 ENOG4108R4R Iron-regulated virulence regulatory protein GO176_RS08305 ENOG4105D05 Receptor GO176_RS08315 ENOG4105BZA Phosphoglycerate kinase GO176_RS08320 ENOG4105D2N Aldolase GO176_RS08325 ENOG4105D64 Mechanosensitive ion channel GO176_RS08335 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GO176_RS08340 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GO176_RS08355 ENOG4105CA9 Pyruvate kinase GO176_RS08360 ENOG410804X Transcriptional regulator GO176_RS08365 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GO176_RS08370 ENOG4107RSM transcriptional regulator GO176_RS08395 ENOG4105CJW magnesium transporter GO176_RS08420 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO176_RS08430 ENOG4105KTH gatB Yqey GO176_RS08435 ENOG4105VCC 30S ribosomal protein S21 GO176_RS08440 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GO176_RS08445 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GO176_RS08450 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GO176_RS08455 ENOG4107ZVW dihydroneopterin aldolase GO176_RS08460 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GO176_RS08465 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GO176_RS08470 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GO176_RS08475 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GO176_RS08480 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GO176_RS08485 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GO176_RS08490 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GO176_RS08495 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GO176_RS08500 ENOG4108K5P (LipO)protein GO176_RS08505 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO176_RS08510 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GO176_RS08515 ENOG4107TH8 cina domain protein GO176_RS08520 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GO176_RS08525 ENOG4105Y3E Modulates RecA activity (By similarity) GO176_RS08530 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GO176_RS08535 ENOG4105CFH Aspartokinase GO176_RS08540 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GO176_RS08590 ENOG4107QSA Oxaloacetate decarboxylase GO176_RS08595 ENOG4105D9Q decarboxylase (Beta subunit) GO176_RS08600 ENOG4105CPQ Dehydrogenase GO176_RS08605 ENOG4105W39 Membrane GO176_RS08615 ENOG4105D9M gamma-glutamylcysteine synthetase GO176_RS08625 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GO176_RS08630 ENOG4108JU6 CBS domain protein GO176_RS08635 ENOG4106KVJ cytochrome C assembly protein GO176_RS08640 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GO176_RS08645 ENOG4105K5M 30s ribosomal protein S16 GO176_RS08650 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GO176_RS08655 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GO176_RS08660 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GO176_RS08665 ENOG4105C0H protease GO176_RS08670 ENOG4105C0H protease GO176_RS08675 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GO176_RS08680 ENOG4105D6Z AFG1 family ATPase GO176_RS08690 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GO176_RS08695 ENOG4108UJD 30S ribosomal protein S9 GO176_RS08705 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GO176_RS08715 ENOG4105EIX cytochrome c1 GO176_RS08720 ENOG4107MKT Stringent starvation protein a GO176_RS08725 ENOG4105KB2 stringent starvation protein b GO176_RS08730 ENOG4105W4M Transport-associated protein GO176_RS08735 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GO176_RS08740 ENOG41082RQ UPF0102 protein GO176_RS08745 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) GO176_RS08750 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GO176_RS08760 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GO176_RS08765 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GO176_RS08770 ENOG4105CJN penicillin-binding protein GO176_RS08775 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GO176_RS08780 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GO176_RS08785 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GO176_RS08790 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GO176_RS08800 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GO176_RS08805 ENOG4105DFU Cell wall formation (By similarity) GO176_RS08810 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GO176_RS08815 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GO176_RS08820 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GO176_RS08825 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GO176_RS08835 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GO176_RS08840 ENOG4105M6F mutator MutT protein GO176_RS08845 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GO176_RS08850 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GO176_RS08855 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GO176_RS08865 ENOG4105PY6 Phenolic acid decarboxylase GO176_RS08870 ENOG4105EJ9 Membrane GO176_RS08875 ENOG4105VP0 transcriptional regulator, lysR family GO176_RS08895 ENOG4105EN6 Membrane GO176_RS08900 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GO176_RS08905 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GO176_RS08920 ENOG4105BZ8 glutamate synthase GO176_RS08925 ENOG4105CBC glutamate synthase GO176_RS08940 ENOG4105N5T Radical SAM Protein GO176_RS08950 ENOG4105BZU Histidine kinase GO176_RS08960 ENOG41065U4 response regulator GO176_RS08970 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GO176_RS08985 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GO176_RS08990 ENOG4105D98 threonine synthase GO176_RS08995 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) GO176_RS09000 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GO176_RS09005 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GO176_RS09020 ENOG4105BZG amino acid carrier protein GO176_RS09025 ENOG4105D1Q UPF0246 protein GO176_RS09035 ENOG4105D9N nucleoside GO176_RS09045 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GO176_RS09050 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GO176_RS09055 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GO176_RS09060 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GO176_RS09070 ENOG4105EAC phosphoserine phosphatase GO176_RS09090 ENOG4105ETT transcriptional Regulator, LysR family GO176_RS09100 ENOG4105ETT transcriptional Regulator, LysR family GO176_RS09185 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GO176_RS09190 ENOG4105FGV Chromate GO176_RS09200 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GO176_RS09205 ENOG4108Y51 tRNA-binding protein GO176_RS09235 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GO176_RS09240 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GO176_RS09245 ENOG4105X2V dna damage-inducible protein GO176_RS09250 ENOG4106P55 Transcriptional regulator GO176_RS09260 ENOG4105DSY exodeoxyribonuclease V, gamma GO176_RS09270 ENOG4107QYX exodeoxyribonuclease v alpha GO176_RS09280 ENOG4107QZM n-acetylglutamate synthase GO176_RS09290 ENOG4105CA3 membrane-bound lytic murein transglycosylase GO176_RS09295 ENOG4105CUZ uba thif-type nad fad binding protein GO176_RS09300 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GO176_RS09305 ENOG4105C9B Cysteine desulfurase GO176_RS09310 ENOG4107S0N DJ-1 family GO176_RS09320 ENOG4105DRB nucleoside-specific channel-forming protein GO176_RS09330 ENOG4105K6V RNA polymerase GO176_RS09340 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO176_RS09345 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GO176_RS09350 ENOG4105CFP Peptidase U32 GO176_RS09355 ENOG4105DH7 May be involved in recombination (By similarity) GO176_RS09360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GO176_RS09365 ENOG4105BZU Histidine kinase GO176_RS09375 ENOG4105C9X ppx gppa phosphatase GO176_RS09380 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GO176_RS09385 ENOG4105C8U phosphate abc transporter GO176_RS09390 ENOG4105E2Z phosphate ABC transporter (Permease GO176_RS09395 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GO176_RS09405 ENOG4105CSR polyphosphate kinase 2 GO176_RS09415 ENOG4105D3R alkyl hydroperoxide reductase GO176_RS09420 ENOG4105C5Q Transcriptional regulator GO176_RS09425 ENOG4107QP3 malate synthase g GO176_RS09430 ENOG4108I9X Isocitrate lyase GO176_RS09435 ENOG4108NVR Methyl-accepting chemotaxis GO176_RS09440 ENOG4105W87 Cbs domain GO176_RS09445 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GO176_RS09450 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GO176_RS09455 ENOG4105VIE preprotein translocase, subunit YajC GO176_RS09460 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GO176_RS09465 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GO176_RS09470 ENOG4105D3W isochorismatase GO176_RS09475 ENOG4105ECY inositol monophosphatase GO176_RS09480 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GO176_RS09485 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GO176_RS09490 ENOG4105C3J Cysteine desulfurase GO176_RS09495 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GO176_RS09500 ENOG4108Z4V iron-sulfur cluster assembly GO176_RS09505 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) GO176_RS09510 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GO176_RS09515 ENOG4108ZIT Ferredoxin, 2FE-2S GO176_RS09520 ENOG4105WVQ Fe-S assembly protein IscX GO176_RS09525 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GO176_RS09530 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GO176_RS09545 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GO176_RS09550 ENOG4105CUT histidyl-tRNA synthetase GO176_RS09555 ENOG4105N21 Membrane GO176_RS09560 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GO176_RS09565 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GO176_RS09580 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GO176_RS09585 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GO176_RS09590 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GO176_RS09600 ENOG4106HK8 GPR1 FUN34 yaaH family protein GO176_RS09605 ENOG4108DQ1 activator toxR GO176_RS09620 ENOG4106PG1 outer membrane usher protein GO176_RS09625 ENOG4108FZ9 Chaperone GO176_RS09640 ENOG4105C09 Bile acid GO176_RS09645 ENOG4105BZG amino acid carrier protein GO176_RS09655 ENOG4105MWK D-amino acid dehydrogenase, small subunit GO176_RS09670 ENOG4105C0D helicase GO176_RS09690 ENOG4105DFP Integrase GO176_RS09700 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GO176_RS09705 ENOG4108Z1B Cyclase dehydrase GO176_RS09710 ENOG4105VDB UPF0125 protein GO176_RS09715 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GO176_RS09720 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GO176_RS09725 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GO176_RS09740 ENOG4105CFG Acts as a chaperone (By similarity) GO176_RS09745 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GO176_RS09775 ENOG4105CFC Transporter GO176_RS09780 ENOG4105C4W S-formylglutathione hydrolase GO176_RS09790 ENOG4105EJC lysr family transcriptional regulator GO176_RS09795 ENOG4108Z6B deaminase GO176_RS09800 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GO176_RS09805 ENOG4107QIK phosphoribosylformylglycinamidine synthase GO176_RS09820 ENOG4105W1I UPF0253 protein GO176_RS09830 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GO176_RS09835 ENOG4108R96 Methyltransferase, YaeB family GO176_RS09855 ENOG4108UPT UPF0178 protein GO176_RS09880 ENOG4105WP7 tRNA pseudouridine synthase C GO176_RS09885 ENOG4105DR9 pseudouridine synthase GO176_RS09890 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GO176_RS09895 ENOG4105CTB Polyprenyl synthetase GO176_RS09900 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GO176_RS09905 ENOG4105E14 MotA TolQ exbB proton channel GO176_RS09910 ENOG4106VK6 Flagellar motor protein GO176_RS09915 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GO176_RS09920 ENOG4105ETT transcriptional Regulator, LysR family GO176_RS09930 ENOG4105M08 Membrane GO176_RS09935 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) GO176_RS09940 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GO176_RS09950 ENOG4105BZU Histidine kinase GO176_RS09960 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GO176_RS09965 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GO176_RS09970 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein GO176_RS09975 ENOG4105D01 (LipO)protein GO176_RS09980 ENOG4108UMI ABC transporter, permease GO176_RS09990 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GO176_RS10000 ENOG4105D4X repressor GO176_RS10005 ENOG4105C5Y PTS System GO176_RS10010 ENOG4105CG3 alpha amylase, catalytic region GO176_RS10015 ENOG4105CXY transporter GO176_RS10025 ENOG4108KX4 response regulator GO176_RS10030 ENOG4105CXY transporter GO176_RS10055 ENOG410624X efflux transporter, rnd family, mfp subunit GO176_RS10060 ENOG4105BZS acriflavin resistance protein GO176_RS10070 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GO176_RS10080 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GO176_RS10090 ENOG4108Z43 UPF0250 protein GO176_RS10095 ENOG4105DZ1 carboxypeptidase GO176_RS10100 ENOG4105K6T rare lipoprotein A GO176_RS10105 ENOG4105CNI cell division protein FtsW GO176_RS10110 ENOG4105CJN penicillin-binding protein GO176_RS10115 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GO176_RS10120 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GO176_RS10125 ENOG4105DJF DNA polymerase III, delta' subunit GO176_RS10130 ENOG4108U2H Rare lipoprotein B GO176_RS10135 ENOG4105C8T Leucyl-tRNA synthetase GO176_RS10140 ENOG4107PAI alpha helical protein GO176_RS10145 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GO176_RS10155 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GO176_RS10160 ENOG4105C9A Phoh family GO176_RS10170 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GO176_RS10175 ENOG4105C5Y PTS System GO176_RS10185 ENOG4105KZ7 phosphocarrier protein hpr GO176_RS10190 ENOG4105C6T cysteine synthase GO176_RS10195 ENOG4105EXN Sulfate transport protein CysZ GO176_RS10200 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) GO176_RS10205 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GO176_RS10210 ENOG41081QG Porin Gram-negative type GO176_RS10220 ENOG4108Z6Z Transcriptional regulator GO176_RS10235 ENOG4107QR8 Thioredoxin GO176_RS10240 ENOG4105E1F short-chain dehydrogenase reductase GO176_RS10270 ENOG4108RE9 Phosphodiesterase GO176_RS10285 ENOG4108DQ1 activator toxR GO176_RS10290 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GO176_RS10295 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GO176_RS10300 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GO176_RS10305 ENOG4105DUX Transporter GO176_RS10315 ENOG4105CAQ asparagine synthetase GO176_RS10320 ENOG4105CKD glutathione-regulated potassium-efflux system protein GO176_RS10325 ENOG4105E2R ROK family GO176_RS10330 ENOG4105CE4 GlcNAc 6-P deacetylase GO176_RS10335 ENOG4105CI1 PTS System GO176_RS10340 ENOG4105CX6 glutaminyL-tRNA synthetase GO176_RS10350 ENOG4108RS6 transposase GO176_RS10355 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GO176_RS10360 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GO176_RS10365 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GO176_RS10370 ENOG4108S3P Sporulation domain protein GO176_RS10375 ENOG4105E96 Colicin v production protein GO176_RS10380 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GO176_RS10385 ENOG4105D3Y Na H antiporter GO176_RS10390 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GO176_RS10395 ENOG4105EIY sodium-type flagellar protein motY GO176_RS10400 ENOG4106WH9 Protein of unknown function (DUF2753) GO176_RS10405 ENOG4108UYE Lactoylglutathione lyase GO176_RS10410 ENOG4105CSM endonuclease III GO176_RS10415 ENOG4105DZB Electron transport complex GO176_RS10420 ENOG4108UQQ Electron transport complex GO176_RS10435 ENOG4108R3D Electron transport complex GO176_RS10445 ENOG4105C6N Formate acetyltransferase GO176_RS10460 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS10470 ENOG4105CHW UPF0052 protein GO176_RS10475 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GO176_RS10480 ENOG4108RIR Molybdenum cofactor biosynthesis protein GO176_RS10490 ENOG4105M00 molybdopterin converting factor, subunit 1 GO176_RS10495 ENOG4108ZAF Molybdopterin GO176_RS10500 ENOG4105BZU Histidine kinase GO176_RS10505 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GO176_RS10515 ENOG4108I5U Uridine phosphorylase GO176_RS10535 ENOG4105DBI uridine monophosphokinase GO176_RS10540 ENOG4108GAE asmA family GO176_RS10545 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GO176_RS10550 ENOG4107SDU Methyl-accepting chemotaxis GO176_RS10565 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GO176_RS10570 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GO176_RS10585 ENOG4105CHU acetyl-coa acetyltransferase GO176_RS10590 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GO176_RS10595 ENOG41069NU Nitroreductase GO176_RS10600 ENOG4105EJC lysr family transcriptional regulator GO176_RS10615 ENOG4105WD1 Membrane GO176_RS10620 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GO176_RS10625 ENOG4107QMP dna polymerase iii subunits gamma and tau GO176_RS10630 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GO176_RS10635 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GO176_RS10640 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GO176_RS10645 ENOG4105KRS Proteinase inhibitor GO176_RS10665 ENOG4105DHI Methyltransferase GO176_RS10670 ENOG4105DSB aldose 1-epimerase GO176_RS10675 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GO176_RS10680 ENOG4105E0X reductase GO176_RS10695 ENOG4105HDK L-asparaginase GO176_RS10710 ENOG4105CIY formyltetrahydrofolate deformylase GO176_RS10725 ENOG41072GX Peptidase M22 Glycoprotease GO176_RS10740 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GO176_RS10745 ENOG4105CEY Amp-dependent synthetase and ligase GO176_RS10750 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GO176_RS10760 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GO176_RS10765 ENOG4107QMS site-determining protein GO176_RS10770 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GO176_RS10775 ENOG4105VNG YcgL domain-containing protein GO176_RS10790 ENOG4105D9N nucleoside GO176_RS10795 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GO176_RS10810 ENOG4107QTH restriction modification system DNA specificity domain GO176_RS10835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO176_RS10845 ENOG4105C4Y ABC transporter GO176_RS10850 ENOG4105CXY transporter GO176_RS10855 ENOG4105BZU Histidine kinase GO176_RS10860 ENOG4108KX4 response regulator GO176_RS10885 ENOG4105DP0 ferredoxin-NADP reductase GO176_RS10895 ENOG4108HPI phosphatidate Cytidylyltransferase GO176_RS10905 ENOG4105BZU Histidine kinase GO176_RS10915 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GO176_RS10925 ENOG4105EJQ L-serine dehydratase GO176_RS10930 ENOG4105CNG UPF0061 protein GO176_RS10935 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GO176_RS10955 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GO176_RS10960 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ GO176_RS10965 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS10980 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GO176_RS10985 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GO176_RS10990 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GO176_RS10995 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GO176_RS11000 ENOG4105K70 DNA-binding protein GO176_RS11005 ENOG4105EIN peptidylprolyl cis-trans isomerase GO176_RS11010 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GO176_RS11015 ENOG4105CAT Cytidine monophosphate kinase GO176_RS11020 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GO176_RS11025 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GO176_RS11030 ENOG4105Q4A inner membrane protein yciS GO176_RS11035 ENOG4105CFV Tetratricopeptide repeat protein GO176_RS11040 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GO176_RS11045 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GO176_RS11065 ENOG4105DCF alanine dehydrogenase GO176_RS11070 ENOG4105EW9 transcriptional regulator AsnC family GO176_RS11075 ENOG4105CNU cell division protein FtsK GO176_RS11080 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GO176_RS11090 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GO176_RS11100 ENOG4108NVR Methyl-accepting chemotaxis GO176_RS11105 ENOG4105K59 histidine triad (HIT) protein GO176_RS11130 ENOG4105D0Y UPF0227 protein GO176_RS11135 ENOG4105CEP NADH dehydrogenase GO176_RS11140 ENOG4105KNA -acetyltransferase GO176_RS11160 ENOG4105D60 lipoprotein releasing system transmembrane protein GO176_RS11165 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GO176_RS11180 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GO176_RS11185 ENOG4105BZ1 (ABC) transporter GO176_RS11190 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GO176_RS11195 ENOG4105W49 UPF0434 protein GO176_RS11200 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GO176_RS11205 ENOG4105ED1 spovr family GO176_RS11220 ENOG4105GNX MltA-interacting MipA family protein GO176_RS11225 ENOG4105XWI UPF0304 protein GO176_RS11235 ENOG4105F1A Pyruvate formate-lyase GO176_RS11240 ENOG4108NVR Methyl-accepting chemotaxis GO176_RS11250 ENOG4105C6N Formate acetyltransferase GO176_RS11260 ENOG4108JEH abc transporter atp-binding protein GO176_RS11265 ENOG4105E89 ABC transporter GO176_RS11270 ENOG4105DSP amino acid AbC transporter GO176_RS11275 ENOG4106YG3 ABC transporter GO176_RS11280 ENOG4105CGK Exodeoxyribonuclease III GO176_RS11285 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS11290 ENOG4106428 Protein of unknown function (DUF2496) GO176_RS11295 ENOG4108URS primosomal replication protein n'' GO176_RS11300 ENOG4105DVT helicase GO176_RS11305 ENOG4105ZU8 porin-like protein H GO176_RS11310 ENOG4108Q67 UPF0319 protein GO176_RS11320 ENOG4105D58 Diguanylate phosphodiesterase GO176_RS11325 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) GO176_RS11330 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GO176_RS11340 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GO176_RS11345 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GO176_RS11350 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GO176_RS11360 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GO176_RS11375 ENOG4107YD3 Thioesterase GO176_RS11385 ENOG4105M8F Biopolymer transport protein exbD tolR GO176_RS11395 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) GO176_RS11400 ENOG4105KCK Peptidoglycan-associated lipoprotein GO176_RS11405 ENOG4105UFD tol-pal system protein YbgF GO176_RS11410 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GO176_RS11420 ENOG4105BZU Histidine kinase GO176_RS11425 ENOG4108RNS Exports L-alanine (By similarity) GO176_RS11435 ENOG4105E98 transcriptional regulator DeoR family GO176_RS11440 ENOG410804X Transcriptional regulator GO176_RS11450 ENOG4105E70 isomerase GO176_RS11455 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB GO176_RS11465 ENOG4105F3R pts system mannose fructose sorbose family iid GO176_RS11470 ENOG4108YTN IIa component GO176_RS11475 ENOG4105CE4 GlcNAc 6-P deacetylase GO176_RS11480 ENOG4105D2N Aldolase GO176_RS11495 ENOG41074DU domain protein GO176_RS11500 ENOG4108P2H Inner membrane protein YjiG GO176_RS11510 ENOG4105C26 Dehydrogenase GO176_RS11525 ENOG41067SE Tetr family transcriptional regulator GO176_RS11530 ENOG4107QPN acyl-Coa dehydrogenase GO176_RS11545 ENOG41090BQ Glutaredoxin GO176_RS11555 ENOG4106KNT transcriptional regulator GO176_RS11560 ENOG4105DY8 decarboxylase GO176_RS11595 ENOG4105BZU Histidine kinase GO176_RS11605 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GO176_RS11625 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GO176_RS11630 ENOG4105CT4 transporter GO176_RS11635 ENOG4105CCT upf0313 protein GO176_RS11640 ENOG4105C5H ABC transporter GO176_RS11670 ENOG4108N3W hemolysin secretion protein GO176_RS11675 ENOG4105BZU Histidine kinase GO176_RS11690 ENOG4107RAN Peptidase, M16 GO176_RS11705 ENOG4105DZ2 Transcriptional regulator GO176_RS11720 ENOG4105D00 flagellar biosynthetic protein flhB GO176_RS11725 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GO176_RS11730 ENOG4105VS8 Flagellar biosynthetic protein fliq GO176_RS11735 ENOG4105CN7 Flagellar biosynthetic protein FliP GO176_RS11740 ENOG4105DD5 Flagellar motor switch protein GO176_RS11750 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GO176_RS11755 ENOG4108ZC9 flagellar basal-body rod protein flgc GO176_RS11760 ENOG4105W00 Flagellar hook capping protein GO176_RS11765 ENOG4105BZE flagellar hook protein, FlgE GO176_RS11770 ENOG4108KPB Flagellar basal-body rod protein FlgF GO176_RS11775 ENOG4105CGA flagellar basal-body rod protein FlgG GO176_RS11780 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GO176_RS11785 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GO176_RS11815 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GO176_RS11820 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GO176_RS11850 ENOG4105I03 Flagellin GO176_RS11855 ENOG4105I03 Flagellin GO176_RS11860 ENOG4105I03 Flagellin GO176_RS11865 ENOG410804A Flagellar hook-associated 2 domain-containing protein GO176_RS11895 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO176_RS11900 ENOG4107RD7 Flagellar Motor Protein, MotA GO176_RS11905 ENOG4105ER2 Ompa motb domain protein GO176_RS11915 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GO176_RS11920 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS11930 ENOG4105K9H YciI-like protein GO176_RS11935 ENOG4105NAU thioesterase Superfamily protein GO176_RS11940 ENOG4107835 probably involved in intracellular septation (By similarity) GO176_RS11945 ENOG4105CK2 sodium dicarboxylate symporter GO176_RS11950 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GO176_RS11955 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GO176_RS11960 ENOG4105DK0 Indole-3-glycerol phosphate synthase GO176_RS11965 ENOG4108I0Q anthranilate phosphoribosyltransferase GO176_RS11970 ENOG4105DDQ anthranilate synthase GO176_RS11975 ENOG4105CRQ synthase (Component I) GO176_RS11985 ENOG4105DB7 PHP domain protein GO176_RS12020 ENOG4108UHU Aldolase GO176_RS12025 ENOG4105E2D ec 3.2.1.52 GO176_RS12030 ENOG4107RTD sua5 ycio yrdc ywlc family protein GO176_RS12035 ENOG4105FE9 pseudouridine synthase GO176_RS12040 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GO176_RS12045 ENOG4105C4R Atp-dependent dna helicase GO176_RS12055 ENOG4108JJ8 (ABC) transporter GO176_RS12060 ENOG4108JJ9 ABC, transporter GO176_RS12065 ENOG4105C3M thioredoxin reductase GO176_RS12095 ENOG4107GZ4 SanA protein GO176_RS12105 ENOG4108Z4X TRANSCRIPTIONal GO176_RS12120 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GO176_RS12130 ENOG4107R1I NAD-dependent malic enzyme GO176_RS12150 ENOG4108R4R Iron-regulated virulence regulatory protein GO176_RS12165 ENOG4107S6Z Na H antiporter GO176_RS12170 ENOG4105CFQ glutamine synthetase GO176_RS12175 ENOG4108Z86 Glutamine amidotransferase GO176_RS12180 ENOG4107VRI Transcriptional regulator GO176_RS12185 ENOG4105C26 Dehydrogenase GO176_RS12190 ENOG4105CJP fad dependent oxidoreductase GO176_RS12200 ENOG4105DWY Agmatine deiminase GO176_RS12205 ENOG4105C26 Dehydrogenase GO176_RS12215 ENOG4105C8V SAICAR synthetase GO176_RS12235 ENOG4108ZG0 Ompa motb domain protein GO176_RS12255 ENOG4105CQB FAD linked oxidase domain protein GO176_RS12280 ENOG4105CGP Urocanate hydratase GO176_RS12285 ENOG41088SP formiminoglutamate hydrolase GO176_RS12290 ENOG4105CI2 imidazolone-5-propionate hydrolase GO176_RS12300 ENOG41060QA UPF0267 protein GO176_RS12310 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GO176_RS12320 ENOG4105CQ2 DNA polymerase GO176_RS12325 ENOG4105WH1 Two component transcriptional regulator luxr family GO176_RS12370 ENOG4105BZU Histidine kinase GO176_RS12385 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GO176_RS12390 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GO176_RS12395 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GO176_RS12405 ENOG4105FQ6 thiopurine methyltransferase GO176_RS12410 ENOG4107SDU Methyl-accepting chemotaxis GO176_RS12415 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GO176_RS12440 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GO176_RS12445 ENOG41067MG lrgb family GO176_RS12455 ENOG4105CJB Exodeoxyribonuclease I GO176_RS12485 ENOG4108ETY sodium dicarboxylate symporter GO176_RS12495 ENOG4107XWI flavin reductase domain protein, FMN-binding GO176_RS12500 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GO176_RS12505 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GO176_RS12525 ENOG4108IU2 vtamin B12-transporter permease GO176_RS12530 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GO176_RS12645 ENOG4105ETE Transcriptional regulator (LacI family GO176_RS12655 ENOG4107FKK extracellular solute-binding protein family 1 GO176_RS12665 ENOG4105EG2 ABC transporter, permease GO176_RS12675 ENOG4105C4C beta-galactosidase GO176_RS12685 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS12690 ENOG4108UW5 maltose o-acetyltransferase GO176_RS12715 ENOG4105DND Transcriptional regulator GO176_RS12725 ENOG4108VKG metal-dependent hydrolase GO176_RS12740 ENOG41090FY type IV pilus biogenesis stability protein PilW GO176_RS12745 ENOG4105CVG Homoserine O-transsuccinylase GO176_RS12765 ENOG4107V40 secretion protein, HlyD family GO176_RS12780 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GO176_RS12785 ENOG4106YYS transcriptional regulatory protein GO176_RS12795 ENOG4107R88 Chemotaxis protein (CheV) GO176_RS12805 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GO176_RS12810 ENOG4105EM7 Selenocysteine-specific translation elongation factor GO176_RS12815 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) GO176_RS12820 ENOG4108JPZ Monovalent cation H antiporter subunit D GO176_RS12825 ENOG4107TDF Formate hydrogenlyase subunit 4 GO176_RS12830 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GO176_RS12840 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit GO176_RS12845 ENOG4105I6X formate hydrogenlyase maturation GO176_RS12850 ENOG4108MG9 hydrogenase 3 maturation protease GO176_RS12855 ENOG4108RC0 Electron transport protein GO176_RS12865 ENOG4108JUA Transcriptional regulator GO176_RS12870 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GO176_RS12885 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF GO176_RS12895 ENOG4105C45 hydrogenase expression formation protein (HypE) GO176_RS12900 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GO176_RS12905 ENOG4107RSS Hydrogenase accessory protein HypB GO176_RS12910 ENOG41090EX DsrE family GO176_RS12915 ENOG4107RM6 sulfurtransferase GO176_RS12930 ENOG4105BZU Histidine kinase GO176_RS12970 ENOG4105TKZ Tail Sheath GO176_RS13010 ENOG4105ED4 portal protein GO176_RS13015 ENOG4105MZU cell filamentation protein GO176_RS13095 ENOG4105VZ1 Replication Protein GO176_RS13170 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GO176_RS13180 ENOG4107SDU Methyl-accepting chemotaxis GO176_RS13190 ENOG4105D64 Mechanosensitive ion channel GO176_RS13210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GO176_RS13215 ENOG4105GR3 Histidine kinase GO176_RS13220 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GO176_RS13255 ENOG4105DR4 Methyltransferase GO176_RS13265 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GO176_RS13270 ENOG4108MN8 Membrane GO176_RS13275 ENOG4105CDA abc transporter atp-binding protein GO176_RS13280 ENOG4105DRP amino acid AbC transporter GO176_RS13285 ENOG4105EZ7 amino acid ABC transporter GO176_RS13290 ENOG4107QXX ABC transporter GO176_RS13300 ENOG410667J hydrolase GO176_RS13305 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GO176_RS13315 ENOG4105CUW cytochrome C-TYPE protein GO176_RS13320 ENOG4107QY8 reductase GO176_RS13325 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) GO176_RS13335 ENOG4105E9S glutaredoxin 2 GO176_RS13350 ENOG4105BZU Histidine kinase GO176_RS13360 ENOG4105BZU Histidine kinase GO176_RS13365 ENOG4105CFG Acts as a chaperone (By similarity) GO176_RS13380 ENOG4106TD9 Diguanylate cyclase GO176_RS13410 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GO176_RS13415 ENOG4105CQ7 ATP-dependent helicase GO176_RS13450 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GO176_RS13460 ENOG4107QZF nitrite reductase NADPH large subunit GO176_RS13475 ENOG4108SBK dioxygenase, subunit beta GO176_RS13480 ENOG4105FUY alpha subunit GO176_RS13485 ENOG4108W5M transcriptional regulator GO176_RS13490 ENOG4108K2P TRANSCRIPTIONal GO176_RS13505 ENOG4105CTD carboxy-peptidase GO176_RS13510 ENOG4108WC9 type VI secretion system effector, hcp1 family GO176_RS13515 ENOG4105CS6 Rhs element vgr protein GO176_RS13540 ENOG4105BZG amino acid carrier protein GO176_RS13555 ENOG4108RS6 transposase GO176_RS13560 ENOG4105E0X reductase GO176_RS13570 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GO176_RS13590 ENOG4105QNR S1 RNA binding domain protein GO176_RS13595 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GO176_RS13600 ENOG4105DY2 Paraquat-inducible protein b GO176_RS13605 ENOG4105H2K paraquat-inducible protein a GO176_RS13610 ENOG4105BZ1 (ABC) transporter GO176_RS13615 ENOG4108ZGC gaf domain protein GO176_RS13620 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GO176_RS13625 ENOG4105CN1 protease GO176_RS13640 ENOG4105CD8 aminopeptidase N GO176_RS13650 ENOG4105C7I Dehydrogenase GO176_RS13660 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GO176_RS13665 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GO176_RS13675 ENOG4105C5H ABC transporter GO176_RS13690 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GO176_RS13695 ENOG4105DAN ATP-dependent protease GO176_RS13700 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GO176_RS13715 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GO176_RS13720 ENOG4105BZU Histidine kinase GO176_RS13735 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GO176_RS13750 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) GO176_RS13760 ENOG4105C59 p-type ATPase GO176_RS13775 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GO176_RS13780 ENOG4105Q9Y Universal stress protein GO176_RS13785 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GO176_RS13805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO176_RS13810 ENOG4105F38 ABC transporter, permease GO176_RS13815 ENOG4105D38 putrescine abc transporter GO176_RS13820 ENOG4107RUE extracellular solute-binding protein family 1 GO176_RS13825 ENOG4107RUE extracellular solute-binding protein family 1 GO176_RS13850 ENOG4105QAX Iron-sulfur GO176_RS13865 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GO176_RS13885 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GO176_RS13900 ENOG4105BZU Histidine kinase GO176_RS13905 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS13915 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component GO176_RS13920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO176_RS13925 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GO176_RS13945 ENOG4106IUH DTW domain containing protein GO176_RS13955 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS13960 ENOG4107TT5 NLP P60 protein GO176_RS13970 ENOG4105FGM Fructosamine kinase GO176_RS13980 ENOG4108R6K riboflavin synthase, subunit alpha GO176_RS14000 ENOG4108NRW Phospholipase, patatin family GO176_RS14020 ENOG4109015 Biopolymer transport protein exbD tolR GO176_RS14040 ENOG4105QNF Outer membrane lipoprotein GO176_RS14050 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GO176_RS14065 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GO176_RS14070 ENOG4108IJ9 (ABC) transporter GO176_RS14075 ENOG4105E98 transcriptional regulator DeoR family GO176_RS14085 ENOG4105XEP YhcH YjgK YiaL family protein GO176_RS14105 ENOG4108RXX maleylacetoacetate isomerase GO176_RS14115 ENOG4105F1J Homogentisate 1,2-dioxygenase GO176_RS14120 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GO176_RS14125 ENOG4107XTP (EAL) domain protein GO176_RS14130 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GO176_RS14150 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO176_RS14155 ENOG4105CW7 secretion protein, HlyD family GO176_RS14165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GO176_RS14175 ENOG4108I0Z Aconitate hydratase GO176_RS14180 ENOG4105BZN citrate synthase GO176_RS14185 ENOG4105CR4 methylisocitrate lyase GO176_RS14195 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GO176_RS14225 ENOG4107SDZ Galactoside transport system permease protein mglC GO176_RS14230 ENOG4105C2J ABC transporter GO176_RS14240 ENOG4105CNT hydrolase family 2 GO176_RS14255 ENOG4108RCM Nitroreductase GO176_RS14260 ENOG41067V3 Antibiotic biosynthesis monooxygenase GO176_RS14270 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS14300 ENOG4105D9U N-acetyltransferase GO176_RS14305 ENOG4108JU8 Transcriptional regulator GO176_RS14310 ENOG4106K28 UPF0283 membrane protein GO176_RS14315 ENOG4105CM6 amino acid regulated cytosolic protein GO176_RS14330 ENOG4105CRQ synthase (Component I) GO176_RS14335 ENOG4105BZU Histidine kinase GO176_RS14345 ENOG4105P8F nudix hydrolase GO176_RS14350 ENOG4105C44 Serine transporter GO176_RS14355 ENOG4105EJQ L-serine dehydratase GO176_RS14360 ENOG4105DJY efflux transporter, rnd family, mfp subunit GO176_RS14365 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GO176_RS14385 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GO176_RS14390 ENOG4108NVR Methyl-accepting chemotaxis GO176_RS14395 ENOG4105C5S asparaginyl-tRNA synthetase GO176_RS14410 ENOG4105CGF Aromatic amino acid aminotransferase GO176_RS14425 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GO176_RS14430 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS14435 ENOG4105C94 Transporter GO176_RS14465 ENOG4105CH5 extracellular solute-binding protein, family 7 GO176_RS14480 ENOG4105C5X domain protein GO176_RS14485 ENOG4105EAQ (twin-arginine translocation) pathway signal GO176_RS14490 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GO176_RS14515 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GO176_RS14525 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GO176_RS14530 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GO176_RS14535 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GO176_RS14540 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GO176_RS14565 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GO176_RS14570 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GO176_RS14575 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS14585 ENOG4105CH5 extracellular solute-binding protein, family 7 GO176_RS14595 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS14600 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) GO176_RS14625 ENOG4105CDV Ompa motb domain protein GO176_RS14630 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GO176_RS14645 ENOG4108I0Y (ABC) transporter GO176_RS14650 ENOG4105UQX Mate efflux family protein GO176_RS14655 ENOG4105CGD Nad-dependent epimerase dehydratase GO176_RS14665 ENOG4105C2C drug resistance transporter, Bcr CflA GO176_RS14670 ENOG4105I08 Pseudouridine synthase GO176_RS14675 ENOG4105CFI type iii restriction protein res subunit GO176_RS14685 ENOG4105ETX regulatoR GO176_RS14690 ENOG4105ECM Sensor protein basS pmrB GO176_RS14695 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GO176_RS14700 ENOG4107XVH Transcriptional regulator GO176_RS14710 ENOG4108K70 Transcriptional regulator GO176_RS14715 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GO176_RS14725 ENOG4107TT2 Auxin Efflux Carrier GO176_RS14740 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GO176_RS14755 ENOG41080VW acetyltransferase GO176_RS14785 ENOG4105VEQ Cold shock protein GO176_RS14800 ENOG4105C44 Serine transporter GO176_RS14810 ENOG4105CJ1 ABC, transporter GO176_RS14815 ENOG4107QWP ABC-2 type transporter GO176_RS14825 ENOG4105XZD Fe-S protein GO176_RS14835 ENOG4105VNH ABC transporter solute-binding protein GO176_RS14840 ENOG4105CXZ ABC transporter, permease GO176_RS14845 ENOG4108VGW abc transporter atp-binding protein GO176_RS14850 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GO176_RS14855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GO176_RS14865 ENOG4108W1A pseudouridine synthase GO176_RS14875 ENOG4105C8J )-transporter GO176_RS14885 ENOG4105C28 cystathionine GO176_RS14890 ENOG4108R3E Dna-3-methyladenine glycosylase i GO176_RS14905 ENOG4105DJY efflux transporter, rnd family, mfp subunit GO176_RS14915 ENOG4105YYT phage shock protein B GO176_RS14920 ENOG41087YS Phage shock protein A GO176_RS14925 ENOG4105E51 psp operon transcriptional activator GO176_RS14930 ENOG4108J59 Extracellular solute-binding protein, family 5 GO176_RS14935 ENOG4108I5W peptide transport system, permease protein GO176_RS14940 ENOG4108EU3 peptide transport system, permease GO176_RS14945 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GO176_RS14950 ENOG4108JQ2 peptide transport system atp-binding protein GO176_RS14965 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GO176_RS14985 ENOG4107QY8 reductase GO176_RS15005 ENOG4105TMB Formate nitrite transporter GO176_RS15020 ENOG4105CVI Transcriptional regulator GO176_RS15025 ENOG4108535 NAD dependent epimerase/dehydratase family GO176_RS15030 ENOG4105GFG DUF218 domain GO176_RS15035 ENOG4107104 thymidine kinase GO176_RS15040 ENOG4105C9M aspartyl-trna synthetase GO176_RS15045 ENOG41081XQ Conserved Protein GO176_RS15055 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GO176_RS15060 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GO176_RS15075 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) GO176_RS15080 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GO176_RS15085 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GO176_RS15090 ENOG4106371 Methyltransferase GO176_RS15100 ENOG4106WF9 DNA-binding transcriptional regulator TorR GO176_RS15105 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GO176_RS15110 ENOG4105ETE Transcriptional regulator (LacI family GO176_RS15115 ENOG4105HP8 regulator of competence-specific genes GO176_RS15135 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GO176_RS15140 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GO176_RS15145 ENOG4105BZU Histidine kinase GO176_RS15150 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GO176_RS15155 ENOG4105RKX Protein of unknown function (DUF2498) GO176_RS15170 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GO176_RS15180 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GO176_RS15190 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GO176_RS15195 ENOG4105VEQ Cold shock protein GO176_RS15205 ENOG4105FCD Major Facilitator GO176_RS15210 ENOG4105U3E Transcriptional regulator GO176_RS15220 ENOG4108R99 pseudouridine synthase GO176_RS15225 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GO176_RS15230 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GO176_RS15245 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GO176_RS15250 ENOG4105CIH Imidazole acetol-phosphate transaminase GO176_RS15255 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GO176_RS15260 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GO176_RS15270 ENOG4107S6Z Na H antiporter GO176_RS15280 ENOG4107RE1 Inosine-guanosine kinase GO176_RS15285 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GO176_RS15290 ENOG41075W9 High frequency lysogenization protein HflD homolog GO176_RS15295 ENOG4107QTF adenylosuccinate lyase GO176_RS15315 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GO176_RS15330 ENOG4105DTD Dehydrogenase GO176_RS15340 ENOG4105D0M Protease HtpX homolog GO176_RS15345 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GO176_RS15350 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GO176_RS15355 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GO176_RS15360 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GO176_RS15365 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GO176_RS15375 ENOG4107QZF nitrite reductase NADPH large subunit GO176_RS15385 ENOG4105DG7 nitrate ABC transporter GO176_RS15405 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GO176_RS15420 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GO176_RS15425 ENOG4105D1H recombination factor protein RarA GO176_RS15435 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GO176_RS15440 ENOG4108VAU general secretion pathway protein G GO176_RS15445 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GO176_RS15450 ENOG4105BZU Histidine kinase GO176_RS15455 ENOG4108JJB ABC transporter GO176_RS15460 ENOG4105C7J ABC transporter, permease GO176_RS15470 ENOG4105PQ6 UPF0208 membrane protein GO176_RS15475 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GO176_RS15485 ENOG4107PU6 Membrane GO176_RS15490 ENOG4105CHF Glutathione S-transferase GO176_RS15500 ENOG4108JQ7 (ABC) transporter GO176_RS15505 ENOG4105C3U ABC transporter GO176_RS15510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO176_RS15515 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GO176_RS15520 ENOG4107QSI ABC, transporter GO176_RS15545 ENOG4105CEY Amp-dependent synthetase and ligase GO176_RS15550 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GO176_RS15580 ENOG4105C84 Histidine ammonia-lyase GO176_RS15605 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GO176_RS15615 ENOG4105C2D reductase GO176_RS15620 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GO176_RS15630 ENOG4105D7K pfkb domain protein GO176_RS15645 ENOG4108HKT sucrose-6-phosphate hydrolase GO176_RS15655 ENOG4105C5Y PTS System GO176_RS15665 ENOG4105ETX regulatoR GO176_RS15675 ENOG4105UEI Transcriptional Regulator AraC Family GO176_RS15680 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO176_RS15685 ENOG4105CW7 secretion protein, HlyD family GO176_RS15690 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GO176_RS15700 ENOG4105DEF Extracellular solute-binding protein, family 5 GO176_RS15705 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GO176_RS15710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO176_RS15715 ENOG4108JQ5 ABC transporter GO176_RS15725 ENOG4105C2I pirin domain protein GO176_RS15730 ENOG4105CS2 ec 3.2.1.21 GO176_RS15735 ENOG4105DDV Transcriptional regulator (LacI family GO176_RS15745 ENOG4105E0A ABC, transporter GO176_RS15750 ENOG4105CEY Amp-dependent synthetase and ligase GO176_RS15760 ENOG4107RBR Receptor GO176_RS15765 ENOG4105TVJ transport system, permease GO176_RS15775 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GO176_RS15790 ENOG4105C0W non-ribosomal peptide synthetase GO176_RS15800 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GO176_RS15805 ENOG4105E4F Isochorismate synthase GO176_RS15810 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GO176_RS15815 ENOG4105WQI isochorismatase GO176_RS15820 ENOG4105F27 Major Facilitator GO176_RS15825 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GO176_RS15830 ENOG4105CKD glutathione-regulated potassium-efflux system protein GO176_RS15840 ENOG4108HRK Histidine kinase GO176_RS15845 ENOG4105DY9 regulatoR GO176_RS15875 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GO176_RS15880 ENOG4105C4M (Ubiquinol oxidase) subunit I GO176_RS15885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GO176_RS15890 ENOG4105BZU Histidine kinase GO176_RS15900 ENOG4105DB1 molybdopterin oxidoreductase GO176_RS15905 ENOG4106WHD Tetrathionate reductase GO176_RS15910 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GO176_RS15915 ENOG4106AFQ Histidine kinase GO176_RS15920 ENOG4108ZXC Two component transcriptional regulator, luxr family GO176_RS15925 ENOG4105DIJ Phosphoethanolamine transferase GO176_RS15930 ENOG41080IJ Diacylglycerol kinase GO176_RS15935 ENOG4105E0M Sulfatase GO176_RS15940 ENOG4105C1J atp-dependent rna helicase GO176_RS15960 ENOG410624V efflux system protein GO176_RS15965 ENOG4108IJF Heavy metal efflux pump, CzcA GO176_RS15985 ENOG4108UQN AraC family transcriptional regulator GO176_RS15990 ENOG4108V1U phospholipid-binding protein GO176_RS16015 ENOG4105CS2 ec 3.2.1.21 GO176_RS16025 ENOG4105CID antiterminator GO176_RS16035 ENOG4106NZI LysR family Transcriptional regulator GO176_RS16045 ENOG4105BZU Histidine kinase GO176_RS16060 ENOG4108MNP Glycoprotein polysaccharide metabolism GO176_RS16065 ENOG4105C29 acyl-CoA thioesterase GO176_RS16070 ENOG4108XM1 transcriptional regulator AsnC family GO176_RS16085 ENOG4108JIR Flagellum-specific ATP synthase GO176_RS16100 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GO176_RS16110 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS16125 ENOG4105DD5 Flagellar motor switch protein GO176_RS16130 ENOG4105CN7 Flagellar biosynthetic protein FliP GO176_RS16135 ENOG4105VS8 Flagellar biosynthetic protein fliq GO176_RS16140 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GO176_RS16145 ENOG4105D00 flagellar biosynthetic protein flhB GO176_RS16160 ENOG4105I03 Flagellin GO176_RS16165 ENOG410804A Flagellar hook-associated 2 domain-containing protein GO176_RS16170 ENOG4105MQ3 flagellar protein FliS GO176_RS16195 ENOG4107RD7 Flagellar Motor Protein, MotA GO176_RS16200 ENOG4105ER2 Ompa motb domain protein GO176_RS16240 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS16250 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GO176_RS16255 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) GO176_RS16310 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GO176_RS16315 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GO176_RS16320 ENOG4105CGA flagellar basal-body rod protein FlgG GO176_RS16325 ENOG4108KPB Flagellar basal-body rod protein FlgF GO176_RS16330 ENOG4105BZE flagellar hook protein, FlgE GO176_RS16335 ENOG4105W00 Flagellar hook capping protein GO176_RS16340 ENOG4108ZC9 flagellar basal-body rod protein flgc GO176_RS16345 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GO176_RS16365 ENOG4105E9H Lytic Murein transglycosylase GO176_RS16390 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) GO176_RS16395 ENOG4105HMI Membrane GO176_RS16405 ENOG4105CEY Amp-dependent synthetase and ligase GO176_RS16410 ENOG4105DNI Converts SHCHC to OSB (By similarity) GO176_RS16415 ENOG4108IPT Naphthoate synthase GO176_RS16425 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GO176_RS16430 ENOG4105E4F Isochorismate synthase GO176_RS16435 ENOG4105CHM Aminotransferase GO176_RS16440 ENOG4105DK2 UPF0207 protein GO176_RS16445 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GO176_RS16465 ENOG4105ERU peptidase GO176_RS16470 ENOG4105UBK short-chain dehydrogenase reductase GO176_RS16485 ENOG4105C0B DNA polymerase III (alpha subunit) GO176_RS16490 ENOG4107R88 Chemotaxis protein (CheV) GO176_RS16495 ENOG4105DAG ROK family GO176_RS16500 ENOG4105CA9 Pyruvate kinase GO176_RS16520 ENOG4105C8J )-transporter GO176_RS16535 ENOG4105CI1 PTS System GO176_RS16550 ENOG4105F8V Hydrolase, tatD family GO176_RS16555 ENOG4107QRG dna polymerase iii GO176_RS16560 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GO176_RS16565 ENOG4105HHA aminodeoxychorismate lyase GO176_RS16570 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GO176_RS16575 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GO176_RS16580 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GO176_RS16585 ENOG4105CHR reductase GO176_RS16590 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GO176_RS16595 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GO176_RS16600 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GO176_RS16605 ENOG4105VGS 50s ribosomal protein l32 GO176_RS16615 ENOG4108UHJ MAF-like protein GO176_RS16620 ENOG4105EI2 Pseudouridine synthase GO176_RS16625 ENOG4105C03 ribonuclease GO176_RS16635 ENOG4105CHH sulfate transporter GO176_RS16645 ENOG4108RS6 transposase GO176_RS16650 ENOG4108EKI Dehydrogenase GO176_RS16655 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GO176_RS16660 ENOG4105EYW Ion transport protein GO176_RS16665 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GO176_RS16670 ENOG4105DFD Na H antiporter GO176_RS16690 ENOG4105E68 Sulfatase GO176_RS16700 ENOG4105G2Y Transcriptional regulator GO176_RS16705 ENOG4105CNH Multidrug resistance protein MdtL GO176_RS16720 ENOG4105J12 Multidrug resistance protein mdtN GO176_RS16735 ENOG4105DGU Histone deacetylase GO176_RS16750 ENOG4105E2X shikimate dehydrogenase GO176_RS16780 ENOG4105GAK amidohydrolase 2 GO176_RS16790 ENOG4105JSC dimethylmenaquinone methyltransferase GO176_RS16795 ENOG4105KHM amidohydrolase 2 GO176_RS16800 ENOG4105DDW LysR family Transcriptional regulator GO176_RS16815 ENOG4108FN7 Aldo keto reductase GO176_RS16830 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS16835 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase GO176_RS16845 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GO176_RS16850 ENOG4105M2J Glutaredoxin GO176_RS16855 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GO176_RS16870 ENOG410903C (LipO)protein GO176_RS16875 ENOG4108M1T Cytochrome c-type biogenesis protein GO176_RS16880 ENOG4108M1T Cytochrome c-type biogenesis protein GO176_RS16885 ENOG4107QX9 Thiol disulfide interChange protein GO176_RS16890 ENOG4105DA4 cytochrome c-type biogenesis protein GO176_RS16900 ENOG4105X3C heme exporter protein GO176_RS16905 ENOG41060IM Heme exporter protein GO176_RS16910 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GO176_RS16925 ENOG4108V3W Chemotaxis protein, CheW GO176_RS16935 ENOG4107QJE Chromosome Partitioning Protein GO176_RS16940 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GO176_RS16945 ENOG4105CBS Chea signal transduction histidine kinase GO176_RS16950 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GO176_RS16955 ENOG4108VYJ response regulator receiver protein GO176_RS16960 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO176_RS16965 ENOG4107R21 site-determining protein GO176_RS16970 ENOG4105FZW flagellar biosynthesis regulator FlhF GO176_RS16975 ENOG4105D7B Flagellar biosynthesis protein flha GO176_RS16980 ENOG4108BY2 phosphohistidine phosphatase GO176_RS16985 ENOG4107QXK peptidase GO176_RS16990 ENOG4106ZCM YecM protein GO176_RS16995 ENOG4105C75 arginyL-tRNA synthetase GO176_RS17015 ENOG4105XFK Ferrous iron transport protein A GO176_RS17020 ENOG41075H3 AraC family transcriptional regulator GO176_RS17025 ENOG4105NXV High-affinity zinc uptake system protein GO176_RS17030 ENOG4105FDK ABC transporter GO176_RS17035 ENOG4105FAV ABC, transporter GO176_RS17040 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GO176_RS17045 ENOG4105CMV Succinyl-CoA synthetase subunit beta GO176_RS17050 ENOG4105C7S Dehydrogenase GO176_RS17055 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GO176_RS17060 ENOG4105E33 succinate dehydrogenase GO176_RS17065 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GO176_RS17070 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GO176_RS17075 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GO176_RS17080 ENOG4105BZN citrate synthase GO176_RS17085 ENOG4107QNR UPF0135 protein GO176_RS17095 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GO176_RS17100 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GO176_RS17105 ENOG4105EV9 Alpha Beta Hydrolase GO176_RS17115 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GO176_RS17120 ENOG41067MG lrgb family GO176_RS17125 ENOG4105VAW lrga family GO176_RS17130 ENOG4105CMU LysR family (Transcriptional regulator GO176_RS17140 ENOG41090R7 Ferric uptake GO176_RS17145 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GO176_RS17155 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GO176_RS17160 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GO176_RS17170 ENOG4105MH2 YfcL protein GO176_RS17175 ENOG4108BPE -transporting atpase GO176_RS17180 ENOG4105EN6 Membrane GO176_RS17185 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GO176_RS17190 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GO176_RS17205 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GO176_RS17210 ENOG4105VS8 Flagellar biosynthetic protein fliq GO176_RS17215 ENOG4105CN7 Flagellar biosynthetic protein FliP GO176_RS17220 ENOG4105VTB flagellar biosynthesis protein fliO GO176_RS17225 ENOG4105DD5 Flagellar motor switch protein GO176_RS17230 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GO176_RS17250 ENOG4108JIR Flagellum-specific ATP synthase GO176_RS17260 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GO176_RS17265 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GO176_RS17270 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GO176_RS17275 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS17280 ENOG4105BZU Histidine kinase GO176_RS17285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS17290 ENOG4105MQ3 flagellar protein FliS GO176_RS17300 ENOG4107W9T flagellar hook-associated GO176_RS17305 ENOG41063QE flagellar protein FlaG GO176_RS17310 ENOG4105I03 Flagellin GO176_RS17315 ENOG4105I03 Flagellin GO176_RS17320 ENOG4105I03 Flagellin GO176_RS17325 ENOG4105EZR dyp-type peroxidase family protein GO176_RS17330 ENOG4105QZU Inner membrane protein YfeZ GO176_RS17345 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GO176_RS17360 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GO176_RS17365 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GO176_RS17370 ENOG4105CMR udp-glucose 4-epimerase GO176_RS17380 ENOG4105KUZ arsenate reductase GO176_RS17400 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GO176_RS17405 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GO176_RS17410 ENOG4105RH4 Glycine cleavage system transcriptional repressor GO176_RS17415 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GO176_RS17420 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS17435 ENOG4105ERG peptidase m48, ste24p GO176_RS17440 ENOG4105K89 arsenate reductase GO176_RS17445 ENOG4105CS1 NAD(P)H quinone oxidoreductase GO176_RS17460 ENOG4105C2W permease GO176_RS17465 ENOG4108Z66 YbaK ebsC protein GO176_RS17470 ENOG4105CGH 5'-nucleotidase GO176_RS17475 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GO176_RS17480 ENOG41063JG Transcriptional regulator GO176_RS17485 ENOG4108YY7 Invasion gene expression up-regulator SirB GO176_RS17490 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GO176_RS17495 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GO176_RS17500 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GO176_RS17505 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) GO176_RS17510 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GO176_RS17515 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GO176_RS17520 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GO176_RS17525 ENOG4105C3G gtp-binding protein GO176_RS17615 ENOG4105I03 Flagellin GO176_RS17625 ENOG4105DTJ flagellar hook-associated protein GO176_RS17635 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GO176_RS17640 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GO176_RS17645 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GO176_RS17650 ENOG4105CGA flagellar basal-body rod protein FlgG GO176_RS17655 ENOG4108KPB Flagellar basal-body rod protein FlgF GO176_RS17660 ENOG4105BZE flagellar hook protein, FlgE GO176_RS17665 ENOG4105W00 Flagellar hook capping protein GO176_RS17670 ENOG4108ZC9 flagellar basal-body rod protein flgc GO176_RS17675 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GO176_RS17680 ENOG4105BZU Histidine kinase GO176_RS17685 ENOG4107R88 Chemotaxis protein (CheV) GO176_RS17735 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GO176_RS17740 ENOG4105C59 p-type ATPase GO176_RS17750 ENOG4105E2D ec 3.2.1.52 GO176_RS17775 ENOG4108DG9 Smr protein MutS2 GO176_RS17780 ENOG4105FE9 pseudouridine synthase GO176_RS17785 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GO176_RS17790 ENOG4105CXB phosphoribosylaminoimidazole synthetase GO176_RS17795 ENOG4108V3E phosphoribosylglycinamide formyltransferase GO176_RS17800 ENOG4105E7A Glutamine amidotransferase GO176_RS17805 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GO176_RS17810 ENOG4107QPN acyl-Coa dehydrogenase GO176_RS17820 ENOG4107RZZ dna polymerase iii epsilon subunit GO176_RS17830 ENOG4105D1A Methyltransferase GO176_RS17835 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GO176_RS17840 ENOG4105E9H Lytic Murein transglycosylase GO176_RS17855 ENOG4108YZA Nitrogen regulatory protein pii GO176_RS17860 ENOG4105N7H Cytochrome GO176_RS17865 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GO176_RS17870 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GO176_RS17880 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GO176_RS17885 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GO176_RS17890 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GO176_RS17895 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GO176_RS17900 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GO176_RS17905 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GO176_RS17915 ENOG4105DZP Membrane-associated zinc metalloprotease GO176_RS17920 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GO176_RS17925 ENOG4105KNE Phosphatidate cytidylyltransferase GO176_RS17930 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GO176_RS17935 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GO176_RS17940 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GO176_RS17945 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GO176_RS17950 ENOG4105CE9 30S ribosomal protein S2 GO176_RS17955 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GO176_RS17965 ENOG4108T8E UPF0325 protein GO176_RS17970 ENOG4108ZAI phosphatidylglycerophosphatase a GO176_RS17975 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GO176_RS17980 ENOG4107YIM Involved in the transcription termination process (By similarity) GO176_RS17985 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GO176_RS18000 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GO176_RS18005 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GO176_RS18010 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GO176_RS18015 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GO176_RS18020 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GO176_RS18030 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GO176_RS18040 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GO176_RS18055 ENOG4105C26 Dehydrogenase GO176_RS18060 ENOG4108JPW Aminotransferase GO176_RS18065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GO176_RS18070 ENOG4105CIN aminoacyl-histidine dipeptidase GO176_RS18075 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GO176_RS18080 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GO176_RS18090 ENOG4105C8J )-transporter GO176_RS18120 ENOG4105CJ2 (LipO)protein GO176_RS18125 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GO176_RS18130 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO176_RS18135 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO176_RS18140 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO176_RS18145 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO176_RS18150 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO176_RS18160 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GO176_RS18240 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GO176_RS18245 ENOG4108Z6B deaminase GO176_RS18255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GO176_RS18260 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GO176_RS18265 ENOG4105C34 Pseudouridine synthase GO176_RS18270 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GO176_RS18275 ENOG4105E4C Lytic transglycosylase catalytic GO176_RS18280 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GO176_RS18295 ENOG4108K0B C-di-gmp phosphodiesterase GO176_RS18300 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GO176_RS18305 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GO176_RS18310 ENOG4107SC1 transglycosylase GO176_RS18315 ENOG4105C5H ABC transporter GO176_RS18330 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GO176_RS18335 ENOG4108HRK Histidine kinase GO176_RS18340 ENOG4108NEV two component transcriptional regulator, LytTR family GO176_RS18345 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GO176_RS18350 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GO176_RS18355 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GO176_RS18375 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GO176_RS18380 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GO176_RS18385 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GO176_RS18395 ENOG4105DTN riboflavin biosynthesis protein ribF GO176_RS18405 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GO176_RS18410 ENOG41080HT Transcriptional regulator, arsr family GO176_RS18415 ENOG41063Z6 transcriptional regulator, lysR family GO176_RS18425 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GO176_RS18430 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GO176_RS18435 ENOG4105HF0 Membrane GO176_RS18440 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GO176_RS18445 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GO176_RS18450 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) GO176_RS18460 ENOG4105CPC Aldo Keto reductase GO176_RS18470 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS18485 ENOG4105CWM branched-chain amino acid transport system II carrier protein GO176_RS18490 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GO176_RS18495 ENOG4105C1J atp-dependent rna helicase GO176_RS18500 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GO176_RS18505 ENOG4105BZU Histidine kinase GO176_RS18520 ENOG4108YYD acetyltransferase GO176_RS18525 ENOG4105XPQ lipid carrier protein GO176_RS18530 ENOG4105BZU Histidine kinase GO176_RS18535 ENOG4105CFP Peptidase U32 GO176_RS18540 ENOG4106RZ4 Peptidase U32 GO176_RS18545 ENOG4105C3S Mate efflux family protein GO176_RS18560 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GO176_RS18565 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GO176_RS18570 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GO176_RS18575 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GO176_RS18580 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GO176_RS18585 ENOG4105CHV Transcription elongation factor NusA GO176_RS18590 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GO176_RS18610 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GO176_RS18615 ENOG4105EEI dihydropteroate synthase GO176_RS18620 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GO176_RS18625 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GO176_RS18630 ENOG4105HBR Rna-binding protein GO176_RS18635 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GO176_RS18640 ENOG4107QE9 Inherit from COG: Membrane GO176_RS18660 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GO176_RS18685 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GO176_RS18690 ENOG4105IPI Membrane GO176_RS18695 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GO176_RS18705 ENOG4107QRA Extracellular solute-binding protein, family 5 GO176_RS18715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO176_RS18720 ENOG4105C3U ABC transporter GO176_RS18725 ENOG4108JQ7 (ABC) transporter GO176_RS18750 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GO176_RS18755 ENOG4108RS6 transposase GO176_RS18780 ENOG4108YZA Nitrogen regulatory protein pii GO176_RS18785 ENOG4105XTV UPF0231 protein GO176_RS18790 ENOG4107QIJ Aconitate hydratase 2 GO176_RS18795 ENOG4105D78 K07001 NTE family protein GO176_RS18800 ENOG4105BZ4 penicillin-binding protein GO176_RS18805 ENOG4105CQ7 ATP-dependent helicase GO176_RS18810 ENOG4105PW4 Sugar fermentation stimulation protein homolog GO176_RS18815 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GO176_RS18825 ENOG4105DJ0 Poly(A) Polymerase GO176_RS18830 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GO176_RS18835 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GO176_RS18840 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GO176_RS18845 ENOG4105E3A (ABC) transporter GO176_RS18850 ENOG4105DA5 (ABC) transporter GO176_RS18855 ENOG41077A9 carbonic anhydrase GO176_RS18860 ENOG4108UGV hypoxanthine phosphoribosyltransferase GO176_RS18870 ENOG4107QN2 dihydrolipoyl dehydrogenase GO176_RS18875 ENOG4107QSN dihydrolipoamide acetyltransferase GO176_RS18880 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GO176_RS18885 ENOG41073TP transcriptional regulator GO176_RS18890 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GO176_RS18895 ENOG4105T95 Thiol disulfide interChange protein GO176_RS18900 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GO176_RS18905 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GO176_RS18915 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GO176_RS18925 ENOG4107QHF type ii secretion system protein e GO176_RS18935 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GO176_RS18940 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GO176_RS18945 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GO176_RS18950 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GO176_RS18955 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GO176_RS18960 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GO176_RS18965 ENOG4105IPS esterase GO176_RS18970 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GO176_RS18975 ENOG4108SX3 cytoplasmic protein GO176_RS18985 ENOG4105DFG type I secretion outer membrane protein GO176_RS18990 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GO176_RS18995 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GO176_RS19000 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS19010 ENOG4105I7R Adenylate cyclase GO176_RS19015 ENOG4107IX6 phosphate transport regulator GO176_RS19020 ENOG4105CJ3 phosphate transporter GO176_RS19025 ENOG4106MWK domain protein GO176_RS19040 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GO176_RS19045 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GO176_RS19050 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GO176_RS19065 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GO176_RS19070 ENOG4105BZU Histidine kinase GO176_RS19080 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GO176_RS19085 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GO176_RS19090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GO176_RS19095 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GO176_RS19100 ENOG4105C3F Signal peptidase i GO176_RS19105 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GO176_RS19110 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GO176_RS19125 ENOG4105EMN RNA polymerase sigma factor GO176_RS19140 ENOG4105Y75 tpr repeat protein GO176_RS19160 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GO176_RS19165 ENOG4105D0A hydroxylase GO176_RS19175 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GO176_RS19185 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GO176_RS19190 ENOG4105E66 phosphoriboisomerase A GO176_RS19195 ENOG4108JQ1 Dehydrogenase GO176_RS19200 ENOG4108ZP8 Acetolactate synthase small subunit GO176_RS19205 ENOG4105C7K acetolactate synthase GO176_RS19215 ENOG41064T2 transcriptional regulator, lysR family GO176_RS19235 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GO176_RS19245 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GO176_RS19250 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GO176_RS19295 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GO176_RS19340 ENOG4105EE5 Membrane protein terC GO176_RS19345 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GO176_RS19355 ENOG4105QVC MOSC domain-containing protein GO176_RS19365 ENOG4105ETT transcriptional Regulator, LysR family GO176_RS19380 ENOG4105F27 Major Facilitator GO176_RS19385 ENOG4105EKQ RNA-directed DNA polymerase GO176_RS19445 ENOG4105BZU Histidine kinase GO176_RS19500 ENOG4105BZU Histidine kinase GO176_RS19510 ENOG4108K5H permease YjgP YjgQ family protein GO176_RS19515 ENOG4108M8S permease YjgP YjgQ family protein GO176_RS19520 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GO176_RS19530 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GO176_RS19535 ENOG4105C5I Dehydrogenase GO176_RS19540 ENOG4105D3G Pseudouridine synthase GO176_RS19545 ENOG4105K3M )-transporter GO176_RS19550 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GO176_RS19560 ENOG4105DBV ornithine carbamoyltransferase GO176_RS19565 ENOG4105CXT aspartate transcarbamylase GO176_RS19570 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GO176_RS19575 ENOG4105KME endoribonuclease L-psp GO176_RS19580 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GO176_RS19585 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GO176_RS19590 ENOG4105VFK BolA family GO176_RS19595 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane GO176_RS19600 ENOG4105E3I toluene tolerance GO176_RS19605 ENOG4107PE3 Mammalian cell entry related domain protein GO176_RS19610 ENOG4105CY3 ABC transporter, permease GO176_RS19615 ENOG4105DHJ ABC, transporter GO176_RS19625 ENOG4105C2X Arabinose 5-phosphate isomerase GO176_RS19630 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GO176_RS19640 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GO176_RS19645 ENOG4108IUZ ABC transporter GO176_RS19650 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO176_RS19655 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GO176_RS19660 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GO176_RS19670 ENOG41080Z8 PHOSPHOCARRIER protein GO176_RS19675 ENOG4105CJW magnesium transporter GO176_RS19680 ENOG4105CMS peptidase U62, modulator of DNA gyrase GO176_RS19685 ENOG4105N42 UPF0307 protein GO176_RS19690 ENOG4107T0D ABC, transporter GO176_RS19695 ENOG4106SMU thiamine transporter membrane protein GO176_RS19700 ENOG4105DP9 ABC transporter GO176_RS19710 ENOG4105DFU Cell wall formation (By similarity) GO176_RS19715 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GO176_RS19720 ENOG4105F0N pyrophosphate phospho-hydrolase GO176_RS19730 ENOG41066HZ AIG2-like family GO176_RS19740 ENOG4105CFU surface antigen GO176_RS19745 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GO176_RS19750 ENOG4108UUE Transcriptional regulator GO176_RS19765 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GO176_RS19785 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GO176_RS19795 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) GO176_RS19800 ENOG4105C11 sulfate adenylyltransferase), subunit 2 GO176_RS19805 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GO176_RS19820 ENOG4105C1J atp-dependent rna helicase GO176_RS19835 ENOG4105FHY Opacity-associated protein A GO176_RS19850 ENOG4108ZT0 50S ribosomal protein l17 GO176_RS19855 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GO176_RS19860 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GO176_RS19865 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GO176_RS19870 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GO176_RS19880 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GO176_RS19885 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GO176_RS19890 ENOG4105VPB 50S ribosomal protein L30 GO176_RS19895 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GO176_RS19900 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GO176_RS19905 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GO176_RS19910 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GO176_RS19915 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GO176_RS19920 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GO176_RS19925 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GO176_RS19930 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GO176_RS19935 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GO176_RS19940 ENOG41083MP 50s ribosomal protein l29 GO176_RS19945 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GO176_RS19950 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GO176_RS19955 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GO176_RS19960 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GO176_RS19965 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GO176_RS19970 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GO176_RS19975 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GO176_RS19980 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GO176_RS19985 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GO176_RS19990 ENOG4105C2N RNA methyltransferase TrmH family group 3 GO176_RS20005 ENOG4108UV7 flagellar protein motX GO176_RS20010 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GO176_RS20015 ENOG4105D44 asparaginase GO176_RS20020 ENOG4108YZY peptidylprolyl cis-trans isomerase GO176_RS20025 ENOG4105VKU nucleicacid-binding protein GO176_RS20035 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GO176_RS20040 ENOG4105C5H ABC transporter GO176_RS20050 ENOG4105DNZ Alpha Beta Hydrolase GO176_RS20065 ENOG4107RYR Transcriptional regulator, Crp Fnr family GO176_RS20075 ENOG4105C26 Dehydrogenase GO176_RS20085 ENOG4105C8Y Acetylornithine aminotransferase GO176_RS20090 ENOG4105DDQ anthranilate synthase GO176_RS20100 ENOG4105C31 Tryptophanyl-tRNA synthetase GO176_RS20105 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GO176_RS20110 ENOG4105DJV ribulose-phosphate 3-epimerase GO176_RS20125 ENOG4105D49 3-dehydroquinate synthase GO176_RS20130 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GO176_RS20135 ENOG4105E4G Type IV pilus GO176_RS20160 ENOG4108JQC penicillin-binding protein 1A GO176_RS20170 ENOG4105EHV domain protein GO176_RS20180 ENOG4105CH7 arginosuccinase GO176_RS20185 ENOG4105CDH Citrulline--aspartate ligase GO176_RS20190 ENOG4105CAS nag kinase GO176_RS20195 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GO176_RS20200 ENOG4105CWC Acetylornithine deacetylase GO176_RS20205 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GO176_RS20215 ENOG4105D7W serine acetyltransferase GO176_RS20220 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GO176_RS20225 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GO176_RS20230 ENOG4107YZP Rhodanese domain protein GO176_RS20235 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GO176_RS20245 ENOG4105E33 succinate dehydrogenase GO176_RS20250 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GO176_RS20255 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GO176_RS20260 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GO176_RS20265 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GO176_RS20270 ENOG4105KT7 mgtC SapB transporter GO176_RS20280 ENOG4105DKW ABC transporter GO176_RS20285 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GO176_RS20290 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GO176_RS20315 ENOG4105CP7 Triose-phosphate isomerase GO176_RS20320 ENOG4107QMU Mate efflux family protein GO176_RS20325 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GO176_RS20330 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GO176_RS20335 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GO176_RS20350 ENOG4105ETE Transcriptional regulator (LacI family GO176_RS20355 ENOG4105C25 Primosomal protein n' GO176_RS20360 ENOG4105VFB Binds the 23S rRNA (By similarity) GO176_RS20365 ENOG4105C6K Malic enzyme GO176_RS20370 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GO176_RS20375 ENOG4105C28 cystathionine GO176_RS20380 ENOG4105CFH Aspartokinase GO176_RS20385 ENOG4105SYT Methylenetetrahydrofolate reductase GO176_RS20390 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GO176_RS20395 ENOG4105CBT Fructose-1,6-bisphosphatase GO176_RS20400 ENOG4105CTQ phosphohexokinase GO176_RS20415 ENOG4105E3W Two component transcriptional regulator (Winged helix family GO176_RS20425 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GO176_RS20430 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GO176_RS20445 ENOG4108IJ0 Aspartate ammonia-lyase GO176_RS20450 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GO176_RS20455 ENOG4105CSX c4-dicarboxylate anaerobic carrier GO176_RS20460 ENOG4105CEU Arginine dihydrolase GO176_RS20465 ENOG4105C5B carbamate kinase GO176_RS20470 ENOG4105DBV ornithine carbamoyltransferase GO176_RS20475 ENOG4108RS6 transposase GO176_RS20480 ENOG4105CXT aspartate transcarbamylase GO176_RS20485 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GO176_RS20490 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GO176_RS20510 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GO176_RS20520 ENOG4107QN1 sodium solute GO176_RS20525 ENOG4105EX9 Membrane GO176_RS20530 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GO176_RS20535 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GO176_RS20540 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GO176_RS20545 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GO176_RS20550 ENOG4105CB5 ATP-dependent DNA helicase recG GO176_RS20555 ENOG4105C2W permease GO176_RS20560 ENOG4105E0F Histidine kinase GO176_RS20565 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GO176_RS20570 ENOG4108UHU Aldolase GO176_RS20575 ENOG4105C6Z Gluconate GO176_RS20580 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GO176_RS20590 ENOG4105DIQ Transcriptional regulator GO176_RS20595 ENOG4108RRZ Transcription elongation factor GreB GO176_RS20605 ENOG4105BZM domain protein GO176_RS20615 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GO176_RS20620 ENOG4105MJ2 Competence protein GO176_RS20625 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) GO176_RS20630 ENOG4107RK2 ADP-ribose diphosphatase NudE GO176_RS20635 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GO176_RS20640 ENOG4105PIC general secretion pathway protein N GO176_RS20645 ENOG4105U1E general secretion pathway protein M GO176_RS20650 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) GO176_RS20655 ENOG4108RTD type II secretion system protein K GO176_RS20660 ENOG4108WWZ General secretion pathway protein J GO176_RS20665 ENOG4105X5Z General secretion pathway protein I GO176_RS20670 ENOG4105VWV general secretion pathway protein h GO176_RS20675 ENOG4108VAU general secretion pathway protein G GO176_RS20680 ENOG4105D7Q type ii secretion system GO176_RS20685 ENOG4107QHF type ii secretion system protein e GO176_RS20695 ENOG4108XKW General secretion pathway protein C GO176_RS20700 ENOG4105VEJ Heat shock protein GO176_RS20705 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GO176_RS20710 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GO176_RS20715 ENOG4105JV1 AsmA family GO176_RS20720 ENOG4105SUU thioesterase domain GO176_RS20725 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GO176_RS20730 ENOG4107S2Z UPF0761 membrane protein GO176_RS20750 ENOG4105C5F glutamine synthetase GO176_RS20760 ENOG4105CUX Signal transduction histidine kinase GO176_RS20765 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO176_RS20770 ENOG4105BZU Histidine kinase GO176_RS20775 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GO176_RS20810 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GO176_RS20865 ENOG4108YGG dna repair protein GO176_RS20900 ENOG4105C4R Atp-dependent dna helicase GO176_RS20920 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GO176_RS20925 ENOG4107R73 Mate efflux family protein GO176_RS20935 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GO176_RS20940 ENOG41080IJ Diacylglycerol kinase GO176_RS20945 ENOG4105E55 glycerol-3-phosphate acyltransferase GO176_RS20950 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GO176_RS20955 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GO176_RS20960 ENOG4105X6C Flagellar basal body-associated protein FliL GO176_RS20970 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GO176_RS20975 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO176_RS20985 ENOG4105CAK Cell division ATP-binding protein ftsE GO176_RS20990 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GO176_RS20995 ENOG4106H78 methyltransferase GO176_RS21005 ENOG41076UM multiple antibiotic resistance (MarC)-related protein GO176_RS21035 ENOG4108RMU ferritin dps family protein GO176_RS21050 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GO176_RS21055 ENOG41082YX Transcriptional regulator, arsr family GO176_RS21060 ENOG4105D58 Diguanylate phosphodiesterase GO176_RS21065 ENOG410829K Lysine exporter protein (Lyse ygga) GO176_RS21070 ENOG4108EUD Lysophospholipase GO176_RS21075 ENOG4105DQF Hydrolase GO176_RS21090 ENOG4106IUH DTW domain containing protein GO176_RS21095 ENOG4105BZU Histidine kinase GO176_RS21100 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GO176_RS21105 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GO176_RS21110 ENOG4105CT0 Protein of unknown function, DUF484 GO176_RS21115 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GO176_RS21130 ENOG4105XQ6 frataxin-like protein GO176_RS21135 ENOG4107T0K Adenylate cyclase GO176_RS21140 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GO176_RS21145 ENOG41076E6 Uroporphyrinogen-III Synthase GO176_RS21150 ENOG4105ECF c-methyltransferase GO176_RS21155 ENOG410601J HemY protein GO176_RS21165 ENOG4105XCT Protein of unknown function (DUF2489) GO176_RS21170 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) GO176_RS21185 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GO176_RS21190 ENOG4105C2M dna polymerase I GO176_RS21200 ENOG4105D52 delta-aminolevulinic acid dehydratase GO176_RS21205 ENOG4105F8V Hydrolase, tatD family GO176_RS21210 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GO176_RS21215 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GO176_RS21220 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GO176_RS21225 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GO176_RS21230 ENOG4105JC1 sterol-binding domain protein GO176_RS21235 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GO176_RS21265 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GO176_RS21280 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator GO176_RS21285 ENOG4105C2J ABC transporter GO176_RS21290 ENOG4105CNN ABC, transporter GO176_RS21295 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GO176_RS21300 ENOG4105C2J ABC transporter GO176_RS21305 ENOG4107R9N ABC transporter GO176_RS21315 ENOG4105CBX hi0933 family GO176_RS21320 ENOG4108V6B universal stress protein B GO176_RS21325 ENOG41090A1 ferritin GO176_RS21330 ENOG4108M6U Universal stress protein A GO176_RS21335 ENOG4105EMK carboxylate amino acid amine transporter GO176_RS21345 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GO176_RS21350 ENOG4105BZU Histidine kinase GO176_RS21355 ENOG4108VVK transcriptional Regulator, AsnC GO176_RS21365 ENOG4105C2C drug resistance transporter, Bcr CflA GO176_RS21375 ENOG4105DC7 peptidase M24 GO176_RS21375 ENOG4105DC7 peptidase M24 GO176_RS21380 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GO176_RS21390 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GO176_RS21410 ENOG4105D41 biosynthesis protein thiH GO176_RS21415 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GO176_RS21425 ENOG4105D06 uba thif-type nad fad binding protein GO176_RS21435 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GO176_RS21440 ENOG4105WMR Protein CrcB homolog GO176_RS21445 ENOG4105E3B Multicopper oxidase GO176_RS21515 ENOG4108RR8 protoporphyrinogen oxidase GO176_RS21520 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GO176_RS21525 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GO176_RS21530 ENOG4108DP9 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GO176_RS21535 ENOG4105CHU acetyl-coa acetyltransferase GO176_RS21540 ENOG4105F52 Transcriptional regulator GO176_RS21545 ENOG4105CZQ inner membrane transport protein YdhC GO176_RS21550 ENOG4105F87 Dehydratase GO176_RS21555 ENOG4105E5Q amino acid AbC transporter GO176_RS21560 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GO176_RS21565 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GO176_RS21570 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GO176_RS21575 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GO176_RS21580 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GO176_RS21585 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GO176_RS21590 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GO176_RS21595 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GO176_RS21600 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GO176_RS21605 ENOG410684E atp synthase GO176_RS21610 ENOG4105FA0 parb-like partition protein GO176_RS21615 ENOG4107QJE Chromosome Partitioning Protein GO176_RS21620 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GO176_RS21625 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GO176_RS21635 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GO176_RS21640 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GO176_RS21645 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GO176_RS21650 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GO176_RS21665 ENOG4105E5Q amino acid AbC transporter GO176_RS21670 ENOG4105EAB amino acid AbC transporter GO176_RS21680 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GO176_RS21685 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GO176_RS21690 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GO176_RS21700 ENOG4108ZNX Heat shock protein GO176_RS21705 ENOG4105JKW Valine--pyruvate aminotransferase GO176_RS21710 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GO176_RS21715 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit GO176_RS21730 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) GO176_RS21740 ENOG41064RH membrane protein YliF GO176_RS21745 ENOG4105BZU Histidine kinase GO176_RS21755 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GO176_RS21760 ENOG4105C7B Threonine dehydratase GO176_RS21765 ENOG4105C01 Dihydroxy-acid dehydratase GO176_RS21770 ENOG4105CM2 brancheD-chain amino acid aminotransferase GO176_RS21775 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GO176_RS21785 ENOG4105C0P Mg chelatase subunit ChlI GO176_RS21790 ENOG4106HNH Acyl-transferase GO176_RS21795 ENOG4108Z33 Thiol disulfide Interchange Protein GO176_RS21800 ENOG4105E27 serine threonine protein kinase GO176_RS21810 ENOG4105PC1 Conserved Protein GO176_RS21820 ENOG4108N23 SpoOM-related protein GO176_RS21825 ENOG4108UT2 hemolysin iii GO176_RS21835 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GO176_RS21840 ENOG4105C1A potassium transporter peripheral membrane GO176_RS21845 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GO176_RS21870 ENOG4108RPN Protein smg homolog GO176_RS21880 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GO176_RS21885 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GO176_RS21890 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GO176_RS21900 ENOG4105E2X shikimate dehydrogenase GO176_RS21905 ENOG4105SG3 Protein of unknown function (DUF1488) GO176_RS21910 ENOG4108Z0R Transferase GO176_RS21955 ENOG4105EMY transcriptional regulator GO176_RS21960 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GO176_RS21965 ENOG4105W0Z cytoplasmic protein GO176_RS21970 ENOG4105BZS acriflavin resistance protein GO176_RS21975 ENOG410624X efflux transporter, rnd family, mfp subunit GO176_RS21980 ENOG4105Y7M Transcriptional regulator, TetR family GO176_RS21985 ENOG4105C4R Atp-dependent dna helicase GO176_RS21990 ENOG4105MPD Cytochrome GO176_RS22020 ENOG4108JQ6 ABC transporter GO176_RS22025 ENOG4105DEF Extracellular solute-binding protein, family 5 GO176_RS22030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GO176_RS22035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO176_RS22070 ENOG4105BZS acriflavin resistance protein GO176_RS22075 ENOG4105C1P efflux transporter, rnd family, mfp subunit GO176_RS22090 ENOG4105DC8 reductase GO176_RS22095 ENOG4105D6S protein involved in catabolism of external DNA GO176_RS22100 ENOG4105DGW oligopeptidase A GO176_RS22120 ENOG4105E18 UPF0276 protein GO176_RS22130 ENOG4105C4R Atp-dependent dna helicase GO176_RS22135 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GO176_RS22140 ENOG4105CCF Lysine exporter protein (Lyse ygga) GO176_RS22150 ENOG4105FR1 rard protein GO176_RS22155 ENOG4105C9U ATP-dependent DNA helicase RecQ GO176_RS22170 ENOG4105BZ1 (ABC) transporter GO176_RS22175 ENOG4105E0K tonB-dependent siderophore receptor GO176_RS22180 ENOG4105E0A ABC, transporter GO176_RS22190 ENOG4105S6R Iron-hydroxamate transporter permease subunit GO176_RS22200 ENOG4105DSJ YicC domain protein GO176_RS22205 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GO176_RS22210 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GO176_RS22215 ENOG4105D1S lipid A biosynthesis GO176_RS22220 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GO176_RS22225 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GO176_RS22230 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS22240 ENOG4105KDC 50s ribosomal protein l28 GO176_RS22245 ENOG4105W0E 50S ribosomal protein L33 GO176_RS22255 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GO176_RS22275 ENOG4108PQP glycosyl transferase group 1 GO176_RS22280 ENOG4105CPK Glycosyl transferase (Group 1 GO176_RS22285 ENOG4106WTF Glycosyl transferase, family 2 GO176_RS22290 ENOG4105DKP glycosyl transferase, family 9 GO176_RS22295 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) GO176_RS22310 ENOG4105XA0 heptosyltransferase ii GO176_RS22315 ENOG4105XA0 heptosyltransferase ii GO176_RS22340 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GO176_RS22345 ENOG4105E3R (LipO)protein GO176_RS22355 ENOG4108Y9B (LipO)protein GO176_RS22365 ENOG4105DAY polysaccharide export protein GO176_RS22370 ENOG4107ZF2 Phosphatase GO176_RS22440 ENOG4105C0K Gdp-mannose 4,6-dehydratase GO176_RS22445 ENOG4105C30 Nad-dependent epimerase dehydratase GO176_RS22450 ENOG4105FGF GDP-mannose mannosyl hydrolase GO176_RS22455 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GO176_RS22475 ENOG4105D3Q Sugar transferase GO176_RS22485 ENOG4105CY0 Metallo-Beta-Lactamase GO176_RS22495 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GO176_RS22515 ENOG4108RG0 uracil-dna glycosylase GO176_RS22520 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GO176_RS22525 ENOG4105R2J Conserved Protein GO176_RS22530 ENOG4105CUY Mechanosensitive ion channel GO176_RS22540 ENOG4105K70 DNA-binding protein GO176_RS22550 ENOG4105C12 Phosphoribosylglycinamide synthetase GO176_RS22555 ENOG4105DC1 bifunctional purine biosynthesis protein purh GO176_RS22560 ENOG4105W1Y Transcriptional regulator GO176_RS22565 ENOG4105DKQ ROK family GO176_RS22580 ENOG4108CIP transcriptional regulator GO176_RS22590 ENOG4105DM4 PTS System GO176_RS22595 ENOG4105C8Q Methyl-accepting chemotaxis GO176_RS22600 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GO176_RS22605 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GO176_RS22610 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GO176_RS22615 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GO176_RS22620 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GO176_RS22645 ENOG4105D8G Major Facilitator superfamily GO176_RS22650 ENOG4105BZU Histidine kinase GO176_RS22655 ENOG4105C9X ppx gppa phosphatase GO176_RS22660 ENOG4105C1J atp-dependent rna helicase GO176_RS22665 ENOG4105K63 Thioredoxin GO176_RS22670 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GO176_RS22690 ENOG4107QK7 reductase GO176_RS22725 ENOG4105JIM Phosphatidylserine synthase GO176_RS22735 ENOG4105D4A Cell wall formation (By similarity) GO176_RS22740 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GO176_RS22745 ENOG4105CS9 pantothenic acid kinase GO176_RS22775 ENOG4105PM1 preprotein translocase subunit SecE GO176_RS22780 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GO176_RS22785 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GO176_RS22790 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GO176_RS22795 ENOG4108VZM 50s ribosomal protein L10 GO176_RS22800 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GO176_RS22805 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GO176_RS22810 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GO176_RS22815 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor GO176_RS22825 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GO176_RS22830 ENOG41062JF Transcriptional regulator GO176_RS22840 ENOG41063SB peptidase GO176_RS22845 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GO176_RS22865 ENOG4105DJ4 phosphatidylserine decarboxylase GO176_RS22870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GO176_RS22875 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GO176_RS22925 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GO176_RS22930 ENOG4105K8N protein family UPF0079, ATPase GO176_RS22935 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GO176_RS22945 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GO176_RS22950 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GO176_RS22955 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GO176_RS22960 ENOG4107QJR hflk protein GO176_RS22965 ENOG4105EPW hflc protein GO176_RS22975 ENOG41069P5 Protein slyX homolog GO176_RS22985 ENOG4108V1T peptidylprolyl cis-trans isomerase GO176_RS22990 ENOG4105WWK YheO domain protein GO176_RS23000 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GO176_RS23005 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GO176_RS23010 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GO176_RS23015 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GO176_RS23030 ENOG4105W53 bacterioferritin-associated ferredoxin GO176_RS23035 ENOG4108UQY Iron-storage protein GO176_RS23040 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GO176_RS23045 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GO176_RS23050 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GO176_RS23055 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GO176_RS23065 ENOG4105CDU Replicative dna helicase GO176_RS23070 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GO176_RS23075 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GO176_RS23080 ENOG4107QP8 phosphohexose isomerase GO176_RS23090 ENOG4105MYN Zinc uptake regulation protein GO176_RS23095 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GO176_RS23115 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GO176_RS23120 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GO176_RS23125 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GO176_RS23185 ENOG4105EEQ Na H antiporter GO176_RS23190 ENOG4105C3R Methionine synthase GO176_RS23195 ENOG4105CFH Aspartokinase GO176_RS23200 ENOG4105C5R Aminotransferase GO176_RS23215 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GO176_RS23220 ENOG41086KC Transcriptional regulator GO176_RS23225 ENOG4108UUM single-stranded DNA-binding protein GO176_RS23230 ENOG41062P1 Diguanylate cyclase phosphodiesterase GO176_RS23265 ENOG4107QHF type ii secretion system protein e GO176_RS23315 ENOG4105DFF Rod shape-determining protein mreb GO176_RS23320 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GO176_RS23325 ENOG4105VQ7 Rod shape-determining protein MreD GO176_RS23330 ENOG4108Z03 MAF-like protein GO176_RS23335 ENOG4105C03 ribonuclease