locus-tag	class	description
GO176_RS00010	COG1653	transport
GO176_RS00015	COG3842	ATPase activity
GO176_RS00020	COG0395	ABC-type sugar transport system, permease component
GO176_RS00025	COG1175	transmembrane transport
GO176_RS00040	COG0840	transmembrane signaling receptor activity
GO176_RS00050	COG0800	Aldolase
GO176_RS00055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO176_RS00065	COG0235	Class ii aldolase
GO176_RS00070	COG3254	rhamnose metabolic process
GO176_RS00075	COG4806	L-rhamnose isomerase
GO176_RS00080	COG1070	Carbohydrate kinase
GO176_RS00085	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GO176_RS00115	COG1917	Cupin 2, conserved barrel domain protein
GO176_RS00125	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS00135	COG0517	IMP dehydrogenase activity
GO176_RS00155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO176_RS00165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO176_RS00205	COG3842	ATPase activity
GO176_RS00245	COG1349	DNA-binding transcription factor activity
GO176_RS00265	COG2354	Protein conserved in bacteria
GO176_RS00270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO176_RS00275	COG0418	dihydroorotase activity
GO176_RS00280	COG3217	Mosc domain protein beta barrel domain protein
GO176_RS00280	COG0633	Ferredoxin
GO176_RS00310	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GO176_RS00315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO176_RS00325	COG0848	biopolymer transport protein
GO176_RS00330	COG0811	peptide transport
GO176_RS00335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GO176_RS00345	COG3721	Heme iron utilization protein
GO176_RS00350	COG0748	coenzyme F420 binding
GO176_RS00365	COG1522	sequence-specific DNA binding
GO176_RS00390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO176_RS00395	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GO176_RS00420	COG0784	Response regulator, receiver
GO176_RS00420	COG2205	protein histidine kinase activity
GO176_RS00420	COG5002	protein histidine kinase activity
GO176_RS00440	COG1765	OsmC-like protein
GO176_RS00450	COG0110	maltose O-acetyltransferase activity
GO176_RS00470	COG3188	usher protein
GO176_RS00480	COG3121	Chaperone
GO176_RS00485	COG0579	oxidoreductase
GO176_RS00505	COG0583	DNA-binding transcription factor activity
GO176_RS00510	COG0798	PFAM Bile acid sodium symporter
GO176_RS00515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO176_RS00525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO176_RS00580	COG0513	Belongs to the DEAD box helicase family
GO176_RS00595	COG0840	transmembrane signaling receptor activity
GO176_RS00615	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO176_RS00620	COG1811	Na channel or pump
GO176_RS00640	COG2985	domain, Protein
GO176_RS00650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO176_RS00695	COG3122	Protein conserved in bacteria
GO176_RS00700	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO176_RS00710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO176_RS00715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO176_RS00715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO176_RS00720	COG0509	glycine decarboxylation via glycine cleavage system
GO176_RS00725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO176_RS00735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO176_RS00745	COG0745	RESPONSE REGULATOR receiver
GO176_RS00745	COG3706	GGDEF domain
GO176_RS00750	COG5001	Diguanylate cyclase
GO176_RS00750	COG3300	MHYT domain
GO176_RS00755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO176_RS00805	COG1716	ATPase activity
GO176_RS00805	COG5001	Diguanylate cyclase
GO176_RS00810	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO176_RS00820	COG4181	ATPase activity
GO176_RS00825	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GO176_RS00835	COG1984	allophanate hydrolase subunit 2
GO176_RS00845	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GO176_RS00860	COG0840	transmembrane signaling receptor activity
GO176_RS00865	COG0814	amino acid
GO176_RS00870	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GO176_RS00875	COG0513	Belongs to the DEAD box helicase family
GO176_RS00880	COG1309	transcriptional regulator
GO176_RS00890	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GO176_RS00905	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GO176_RS00935	COG0840	transmembrane signaling receptor activity
GO176_RS00940	COG1943	Transposase
GO176_RS00955	COG0583	DNA-binding transcription factor activity
GO176_RS00960	COG0697	spore germination
GO176_RS00985	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GO176_RS01000	COG0406	alpha-ribazole phosphatase activity
GO176_RS01005	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO176_RS01010	COG1454	alcohol dehydrogenase
GO176_RS01015	COG2207	Transcriptional regulator
GO176_RS01015	COG1609	Transcriptional regulator
GO176_RS01030	COG3634	alkyl hydroperoxide reductase activity
GO176_RS01035	COG0450	alkyl hydroperoxide reductase
GO176_RS01050	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO176_RS01055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO176_RS01060	COG1960	acyl-CoA dehydrogenase activity
GO176_RS01070	COG0183	Belongs to the thiolase family
GO176_RS01080	COG1960	acyl-CoA dehydrogenase activity
GO176_RS01085	COG1024	Enoyl-CoA hydratase
GO176_RS01090	COG1024	Enoyl-CoA hydratase
GO176_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS01125	COG0653	protein targeting
GO176_RS01140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO176_RS01160	COG0512	Glutamine amidotransferase of anthranilate synthase
GO176_RS01160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO176_RS01170	COG1464	Belongs to the NlpA lipoprotein family
GO176_RS01190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO176_RS01195	COG0573	inorganic phosphate transmembrane transporter activity
GO176_RS01205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO176_RS01210	COG0625	glutathione transferase activity
GO176_RS01275	COG2721	sulfolactate sulfo-lyase activity
GO176_RS01290	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO176_RS01300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO176_RS01305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO176_RS01310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO176_RS01330	COG1473	amidohydrolase
GO176_RS01345	COG1280	lysine exporter protein (LysE YggA)
GO176_RS01355	COG0435	Glutathione S-transferase
GO176_RS01360	COG0583	DNA-binding transcription factor activity
GO176_RS01365	COG4145	pantothenate transmembrane transporter activity
GO176_RS01375	COG2423	ornithine cyclodeaminase activity
GO176_RS01390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO176_RS01415	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GO176_RS01425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO176_RS01445	COG0582	viral genome integration into host DNA
GO176_RS01470	COG2974	May be involved in recombination
GO176_RS01590	COG1484	DNA-dependent DNA replication
GO176_RS01640	COG3772	lysozyme
GO176_RS01650	COG5484	DNA packaging
GO176_RS01650	COG3728	DNA packaging
GO176_RS01655	COG5410	chromosome segregation
GO176_RS01790	COG2207	Transcriptional regulator
GO176_RS01810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GO176_RS01820	COG0488	(ABC) transporter
GO176_RS02035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO176_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS02165	COG1252	NADH dehydrogenase
GO176_RS02175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO176_RS02180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO176_RS02185	COG4232	protein-disulfide reductase activity
GO176_RS02195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GO176_RS02200	COG0110	maltose O-acetyltransferase activity
GO176_RS02215	COG3008	intermembrane lipid transfer
GO176_RS02215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO176_RS02240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO176_RS02250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO176_RS02260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO176_RS02275	COG0583	DNA-binding transcription factor activity
GO176_RS02285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO176_RS02295	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GO176_RS02300	COG0513	Belongs to the DEAD box helicase family
GO176_RS02305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO176_RS02330	COG4633	Protein conserved in bacteria
GO176_RS02335	COG4628	conserved protein (DUF2132)
GO176_RS02375	COG0789	Transcriptional regulator
GO176_RS02380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO176_RS02435	COG0454	-acetyltransferase
GO176_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS02480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO176_RS02490	COG0494	nUDIX hydrolase
GO176_RS02495	COG1280	lysine exporter protein (LysE YggA)
GO176_RS02505	COG0456	acetyltransferase
GO176_RS02515	COG1335	isochorismatase
GO176_RS02545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO176_RS02550	COG1309	transcriptional regulator
GO176_RS02560	COG0583	DNA-binding transcription factor activity
GO176_RS02570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO176_RS02585	COG2897	thiosulfate sulfurtransferase activity
GO176_RS02590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO176_RS02600	COG0302	gtp cyclohydrolase
GO176_RS02605	COG0531	amino acid
GO176_RS02625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO176_RS02625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO176_RS02635	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GO176_RS02655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO176_RS02665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO176_RS02675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO176_RS02685	COG3842	ATPase activity
GO176_RS02705	COG2866	Carboxypeptidase
GO176_RS02730	COG4166	transmembrane transport
GO176_RS02735	COG4174	ABC transporter (Permease)
GO176_RS02745	COG4172	Belongs to the ABC transporter superfamily
GO176_RS02750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO176_RS02770	COG5001	Diguanylate cyclase
GO176_RS02770	COG4251	negative regulation of phosphorylation
GO176_RS02770	COG2203	Gaf domain
GO176_RS02770	COG3706	GGDEF domain
GO176_RS02780	COG2199	diguanylate cyclase activity
GO176_RS02795	COG2501	S4 domain
GO176_RS02850	COG3710	Transcriptional regulator
GO176_RS02880	COG1943	Transposase
GO176_RS02890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO176_RS02890	COG2207	Transcriptional regulator
GO176_RS02900	COG2233	PERMEase
GO176_RS02920	COG1953	Uracil, thiamine, allantoin
GO176_RS02930	COG0765	amino acid transport
GO176_RS02935	COG0765	amino acid transport
GO176_RS02965	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO176_RS02985	COG0402	S-adenosylhomocysteine deaminase activity
GO176_RS02990	COG2351	hydroxyisourate hydrolase activity
GO176_RS03030	COG1129	ABC transporter
GO176_RS03035	COG1309	transcriptional regulator
GO176_RS03045	COG3706	GGDEF domain
GO176_RS03055	COG2199	diguanylate cyclase activity
GO176_RS03075	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GO176_RS03110	COG0023	Translation Initiation Factor
GO176_RS03125	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO176_RS03135	COG0045	succinate-CoA ligase (ADP-forming) activity
GO176_RS03135	COG1042	CoA-binding domain protein
GO176_RS03135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO176_RS03140	COG0583	DNA-binding transcription factor activity
GO176_RS03145	COG4771	TonB-dependent receptor
GO176_RS03145	COG1629	transport
GO176_RS03155	COG4533	DNA binding
GO176_RS03165	COG2050	protein possibly involved in aromatic compounds catabolism
GO176_RS03170	COG4783	chaperone-mediated protein folding
GO176_RS03175	COG2824	Alkylphosphonate utilization operon protein PhnA
GO176_RS03190	COG0737	Belongs to the 5'-nucleotidase family
GO176_RS03195	COG3593	DNA synthesis involved in DNA repair
GO176_RS03205	COG0583	DNA-binding transcription factor activity
GO176_RS03210	COG2116	formate transmembrane transporter activity
GO176_RS03220	COG3038	cytochrome b561
GO176_RS03245	COG5001	Diguanylate cyclase
GO176_RS03255	COG0243	molybdopterin cofactor binding
GO176_RS03260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO176_RS03270	COG3437	response regulator, receiver
GO176_RS03280	COG2207	Transcriptional regulator
GO176_RS03285	COG1064	alcohol dehydrogenase
GO176_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS03295	COG1846	Transcriptional regulator
GO176_RS03300	COG0582	viral genome integration into host DNA
GO176_RS03315	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO176_RS03320	COG2199	diguanylate cyclase activity
GO176_RS03320	COG2202	Pas domain
GO176_RS03320	COG2200	EAL domain
GO176_RS03335	COG5001	Diguanylate cyclase
GO176_RS03335	COG4251	negative regulation of phosphorylation
GO176_RS03335	COG2203	Gaf domain
GO176_RS03335	COG3706	GGDEF domain
GO176_RS03375	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GO176_RS03380	COG1140	nitrate reductase beta subunit
GO176_RS03390	COG2223	nitrite transmembrane transporter activity
GO176_RS03395	COG3850	Histidine kinase
GO176_RS03400	COG2197	response regulator
GO176_RS03405	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GO176_RS03410	COG2239	Acts as a magnesium transporter
GO176_RS03415	COG0840	transmembrane signaling receptor activity
GO176_RS03415	COG3290	protein histidine kinase activity
GO176_RS03465	COG1518	maintenance of DNA repeat elements
GO176_RS03480	COG1609	Transcriptional regulator
GO176_RS03490	COG2017	converts alpha-aldose to the beta-anomer
GO176_RS03495	COG3459	Glycosyltransferase 36 associated
GO176_RS03500	COG3842	ATPase activity
GO176_RS03505	COG2723	6-phospho-beta-galactosidase activity
GO176_RS03510	COG0395	ABC-type sugar transport system, permease component
GO176_RS03525	COG1609	Transcriptional regulator
GO176_RS03540	COG0534	Mate efflux family protein
GO176_RS03555	COG2003	Belongs to the UPF0758 family
GO176_RS03585	COG0328	RNA-DNA hybrid ribonuclease activity
GO176_RS03605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO176_RS03630	COG1486	melibiose metabolic process
GO176_RS03635	COG0583	DNA-binding transcription factor activity
GO176_RS03640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO176_RS03645	COG0523	cobalamin synthesis protein
GO176_RS03650	COG1943	Transposase
GO176_RS03655	COG0038	chloride channel
GO176_RS03665	COG0156	8-amino-7-oxononanoate synthase activity
GO176_RS03670	COG0784	Response regulator, receiver
GO176_RS03670	COG2205	protein histidine kinase activity
GO176_RS03675	COG0419	ATPase involved in DNA repair
GO176_RS03680	COG0420	3'-5' exonuclease activity
GO176_RS03685	COG1609	Transcriptional regulator
GO176_RS03690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO176_RS03690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO176_RS03695	COG1105	Belongs to the carbohydrate kinase PfkB family
GO176_RS03700	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GO176_RS03700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO176_RS03700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO176_RS03705	COG0189	ligase activity
GO176_RS03705	COG4067	protein conserved in archaea
GO176_RS03715	COG0602	queuosine metabolic process
GO176_RS03720	COG1328	CTP reductase activity
GO176_RS03775	COG1073	alpha beta
GO176_RS03780	COG0583	DNA-binding transcription factor activity
GO176_RS03785	COG0454	-acetyltransferase
GO176_RS03790	COG2207	Transcriptional regulator
GO176_RS03800	COG1073	alpha beta
GO176_RS03805	COG1073	alpha beta
GO176_RS03810	COG1902	pentaerythritol trinitrate reductase activity
GO176_RS03815	COG4221	oxidoreductase activity
GO176_RS03850	COG1566	PFAM secretion protein HlyD family protein
GO176_RS03855	COG0583	DNA-binding transcription factor activity
GO176_RS03860	COG1280	lysine exporter protein (LysE YggA)
GO176_RS03865	COG0745	RESPONSE REGULATOR receiver
GO176_RS03875	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO176_RS03880	COG0840	transmembrane signaling receptor activity
GO176_RS03895	COG0545	Peptidyl-prolyl cis-trans isomerase
GO176_RS03905	COG0840	transmembrane signaling receptor activity
GO176_RS03910	COG2814	Major facilitator Superfamily
GO176_RS03925	COG3069	C4-dicarboxylate transmembrane transporter activity
GO176_RS03930	COG2197	response regulator
GO176_RS03950	COG0243	molybdopterin cofactor binding
GO176_RS03960	COG3005	denitrification pathway
GO176_RS03970	COG4166	transmembrane transport
GO176_RS03990	COG0183	Belongs to the thiolase family
GO176_RS04005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO176_RS04025	COG3706	GGDEF domain
GO176_RS04030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO176_RS04045	COG1979	alcohol dehydrogenase
GO176_RS04060	COG1879	ABC-type sugar transport system periplasmic component
GO176_RS04065	COG1803	Methylglyoxal synthase
GO176_RS04070	COG1335	isochorismatase
GO176_RS04075	COG0210	DNA helicase
GO176_RS04140	COG1289	transmembrane transporter activity
GO176_RS04165	COG4149	molybdate abc transporter
GO176_RS04170	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO176_RS04200	COG1879	ABC-type sugar transport system periplasmic component
GO176_RS04205	COG2827	Endonuclease containing a URI domain
GO176_RS04225	COG4974	Belongs to the 'phage' integrase family
GO176_RS04250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO176_RS04280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO176_RS04285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO176_RS04295	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GO176_RS04300	COG0247	lactate metabolic process
GO176_RS04315	COG0297	glycogen (starch) synthase activity
GO176_RS04315	COG0438	transferase activity, transferring glycosyl groups
GO176_RS04320	COG0438	transferase activity, transferring glycosyl groups
GO176_RS04355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO176_RS04370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO176_RS04375	COG3118	belongs to the thioredoxin family
GO176_RS04380	COG2814	Major facilitator Superfamily
GO176_RS04405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO176_RS04405	COG1648	precorrin-2 dehydrogenase activity
GO176_RS04415	COG2146	nitrite reductase [NAD(P)H] activity
GO176_RS04420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO176_RS04425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO176_RS04430	COG4160	amino acid transport
GO176_RS04435	COG4215	(ABC) transporter
GO176_RS04440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO176_RS04445	COG1126	abc transporter atp-binding protein
GO176_RS04475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO176_RS04480	COG1120	ATPase activity
GO176_RS04490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO176_RS04495	COG0583	DNA-binding transcription factor activity
GO176_RS04500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO176_RS04515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO176_RS04525	COG1070	Carbohydrate kinase
GO176_RS04535	COG2390	Transcriptional regulator
GO176_RS04545	COG1294	oxidase, subunit
GO176_RS04550	COG1271	oxidase subunit
GO176_RS04560	COG3781	membrane
GO176_RS04565	COG0583	DNA-binding transcription factor activity
GO176_RS04570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO176_RS04585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO176_RS04595	COG0330	HflC and HflK could
GO176_RS04615	COG2207	Transcriptional regulator
GO176_RS04615	COG1917	Cupin 2, conserved barrel domain protein
GO176_RS04620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO176_RS04640	COG4604	ABC transporter, ATP-binding protein
GO176_RS04645	COG4605	iron ion homeostasis
GO176_RS04650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO176_RS04660	COG0121	glutamine amidotransferase
GO176_RS04670	COG4412	M6 family metalloprotease domain protein
GO176_RS04670	COG3291	Pkd domain containing protein
GO176_RS04675	COG5380	lipid catabolic process
GO176_RS04680	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO176_RS04685	COG0840	transmembrane signaling receptor activity
GO176_RS04690	COG1522	sequence-specific DNA binding
GO176_RS04710	COG2814	Major facilitator Superfamily
GO176_RS04740	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO176_RS04745	COG3279	Response regulator of the LytR AlgR family
GO176_RS04750	COG3275	phosphorelay sensor kinase activity
GO176_RS04755	COG4989	oxidoreductase activity
GO176_RS04770	COG0366	Alpha amylase catalytic
GO176_RS04775	COG3227	Zinc metalloprotease (Elastase)
GO176_RS04780	COG3047	cAMP biosynthetic process
GO176_RS04815	COG1482	cell wall glycoprotein biosynthetic process
GO176_RS04820	COG0840	transmembrane signaling receptor activity
GO176_RS04830	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GO176_RS04835	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GO176_RS04845	COG1609	Transcriptional regulator
GO176_RS04855	COG2942	2-epimerase
GO176_RS04860	COG5578	integral membrane protein
GO176_RS04865	COG0395	ABC-type sugar transport system, permease component
GO176_RS04870	COG1175	transmembrane transport
GO176_RS04885	COG0351	phosphomethylpyrimidine kinase
GO176_RS04890	COG1116	anion transmembrane transporter activity
GO176_RS04895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO176_RS04900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO176_RS04905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GO176_RS04915	COG1132	(ABC) transporter
GO176_RS04920	COG1132	(ABC) transporter
GO176_RS04935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO176_RS04955	COG1278	Cold shock
GO176_RS04960	COG1063	alcohol dehydrogenase
GO176_RS04965	COG0156	8-amino-7-oxononanoate synthase activity
GO176_RS04970	COG1012	belongs to the aldehyde dehydrogenase family
GO176_RS04975	COG3284	Transcriptional regulator
GO176_RS04985	COG0346	lactoylglutathione lyase activity
GO176_RS05000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO176_RS05015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GO176_RS05020	COG0363	glucosamine-6-phosphate deaminase activity
GO176_RS05025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO176_RS05055	COG0646	methionine synthase
GO176_RS05055	COG1410	methionine synthase
GO176_RS05060	COG0531	amino acid
GO176_RS05075	COG1929	Belongs to the glycerate kinase type-1 family
GO176_RS05080	COG2610	gluconate transmembrane transporter activity
GO176_RS05085	COG3835	regulator
GO176_RS05090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO176_RS05095	COG4533	DNA binding
GO176_RS05150	COG3188	usher protein
GO176_RS05155	COG3121	Chaperone
GO176_RS05165	COG2885	chlorophyll binding
GO176_RS05165	COG3047	cAMP biosynthetic process
GO176_RS05175	COG1566	PFAM secretion protein HlyD family protein
GO176_RS05190	COG1686	Belongs to the peptidase S11 family
GO176_RS05200	COG0765	amino acid transport
GO176_RS05215	COG1522	sequence-specific DNA binding
GO176_RS05220	COG0010	Belongs to the arginase family
GO176_RS05225	COG1166	arginine decarboxylase activity
GO176_RS05235	COG4175	Glycine betaine
GO176_RS05240	COG4176	ABC-type proline glycine betaine transport system permease component
GO176_RS05245	COG2113	Glycine betaine
GO176_RS05265	COG2239	Acts as a magnesium transporter
GO176_RS05270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GO176_RS05285	COG0113	porphobilinogen synthase activity
GO176_RS05295	COG3437	response regulator, receiver
GO176_RS05295	COG0784	Response regulator, receiver
GO176_RS05320	COG0527	aspartate kinase activity
GO176_RS05325	COG0662	Cupin 2, conserved barrel domain protein
GO176_RS05330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO176_RS05335	COG0456	acetyltransferase
GO176_RS05340	COG4977	sequence-specific DNA binding
GO176_RS05340	COG1917	Cupin 2, conserved barrel domain protein
GO176_RS05345	COG0861	Integral membrane protein TerC family
GO176_RS05355	COG0534	Mate efflux family protein
GO176_RS05360	COG2154	pterin-4-alpha-carbinolamine dehydratase
GO176_RS05365	COG3186	Phenylalanine-4-hydroxylase
GO176_RS05380	COG0642	Histidine kinase
GO176_RS05385	COG0745	RESPONSE REGULATOR receiver
GO176_RS05435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO176_RS05440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GO176_RS05440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GO176_RS05450	COG2197	response regulator
GO176_RS05460	COG3300	MHYT domain
GO176_RS05460	COG5001	Diguanylate cyclase
GO176_RS05490	COG3036	rescue of stalled ribosome
GO176_RS05495	COG1278	Cold shock
GO176_RS05500	COG4681	YaeQ
GO176_RS05505	COG3706	GGDEF domain
GO176_RS05515	COG3604	Transcriptional regulator
GO176_RS05525	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO176_RS05540	COG0366	Alpha amylase catalytic
GO176_RS05560	COG0714	Associated with various cellular activities
GO176_RS05580	COG2304	oxidoreductase activity
GO176_RS05595	COG5001	Diguanylate cyclase
GO176_RS05620	COG3724	N-succinylarginine dihydrolase activity
GO176_RS05625	COG1012	belongs to the aldehyde dehydrogenase family
GO176_RS05650	COG4948	Mandelate Racemase Muconate Lactonizing
GO176_RS05675	COG0583	DNA-binding transcription factor activity
GO176_RS05700	COG3171	Protein conserved in bacteria
GO176_RS05705	COG0589	response to stress
GO176_RS05715	COG3530	Putative quorum-sensing-regulated virulence factor
GO176_RS05725	COG0579	oxidoreductase
GO176_RS05740	COG2204	response regulator
GO176_RS05745	COG2197	response regulator
GO176_RS05750	COG1522	sequence-specific DNA binding
GO176_RS05770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO176_RS05790	COG0251	oxidation-reduction process
GO176_RS05820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO176_RS05825	COG0784	Response regulator, receiver
GO176_RS05825	COG0835	chemotaxis
GO176_RS05830	COG2315	Protein conserved in bacteria
GO176_RS05845	COG3706	GGDEF domain
GO176_RS05900	COG1741	Belongs to the pirin family
GO176_RS05905	COG0745	RESPONSE REGULATOR receiver
GO176_RS06010	COG3501	Rhs element vgr protein
GO176_RS06020	COG2814	Major facilitator Superfamily
GO176_RS06030	COG3123	guanosine phosphorylase activity
GO176_RS06040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO176_RS06045	COG0569	domain protein
GO176_RS06050	COG0668	transmembrane transport
GO176_RS06055	COG2211	Major facilitator Superfamily
GO176_RS06060	COG0840	transmembrane signaling receptor activity
GO176_RS06065	COG1067	ATP-dependent peptidase activity
GO176_RS06075	COG4172	Belongs to the ABC transporter superfamily
GO176_RS06080	COG0583	DNA-binding transcription factor activity
GO176_RS06085	COG1620	l-lactate permease
GO176_RS06090	COG1304	FMN binding
GO176_RS06115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO176_RS06135	COG3152	Membrane
GO176_RS06150	COG1403	HNH endonuclease
GO176_RS06160	COG0519	Catalyzes the synthesis of GMP from XMP
GO176_RS06165	COG0024	Methionine aminopeptidase
GO176_RS06180	COG0583	DNA-binding transcription factor activity
GO176_RS06190	COG1120	ATPase activity
GO176_RS06195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO176_RS06200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO176_RS06205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO176_RS06210	COG4774	siderophore transport
GO176_RS06225	COG3384	dioxygenase
GO176_RS06230	COG0583	DNA-binding transcription factor activity
GO176_RS06240	COG1342	Belongs to the UPF0251 family
GO176_RS06245	COG0583	DNA-binding transcription factor activity
GO176_RS06255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO176_RS06285	COG1917	Cupin 2, conserved barrel domain protein
GO176_RS06285	COG2169	Transcriptional regulator
GO176_RS06290	COG1301	dicarboxylic acid transport
GO176_RS06295	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO176_RS06300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO176_RS06305	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO176_RS06310	COG2259	Doxx family
GO176_RS06315	COG0402	S-adenosylhomocysteine deaminase activity
GO176_RS06340	COG0363	glucosamine-6-phosphate deaminase activity
GO176_RS06355	COG0739	heme binding
GO176_RS06360	COG2213	PTS system mannitol-specific
GO176_RS06360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO176_RS06365	COG0246	Mannitol dehydrogenase
GO176_RS06370	COG3722	fumarate hydratase activity
GO176_RS06380	COG3284	Transcriptional regulator
GO176_RS06390	COG1461	Dihydroxyacetone kinase
GO176_RS06395	COG2376	Dihydroxyacetone kinase
GO176_RS06415	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GO176_RS06420	COG0583	DNA-binding transcription factor activity
GO176_RS06440	COG3302	dmso reductase anchor subunit
GO176_RS06445	COG0437	4 iron, 4 sulfur cluster binding
GO176_RS06450	COG0243	molybdopterin cofactor binding
GO176_RS06455	COG0095	Lipoate-protein ligase
GO176_RS06460	COG0443	Heat shock 70 kDa protein
GO176_RS06480	COG2176	DNA-directed DNA polymerase activity
GO176_RS06495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GO176_RS06500	COG0583	DNA-binding transcription factor activity
GO176_RS06520	COG1609	Transcriptional regulator
GO176_RS06525	COG2814	Major facilitator Superfamily
GO176_RS06535	COG4221	oxidoreductase activity
GO176_RS06540	COG0583	DNA-binding transcription factor activity
GO176_RS06555	COG3706	GGDEF domain
GO176_RS06560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO176_RS06570	COG3304	Inner membrane component domain
GO176_RS06575	COG2329	Antibiotic biosynthesis monooxygenase
GO176_RS06590	COG2207	Transcriptional regulator
GO176_RS06590	COG1609	Transcriptional regulator
GO176_RS06595	COG1335	isochorismatase
GO176_RS06630	COG1349	DNA-binding transcription factor activity
GO176_RS06635	COG2084	Dehydrogenase
GO176_RS06640	COG3395	kinase activity
GO176_RS06645	COG0235	Class ii aldolase
GO176_RS06650	COG3622	Belongs to the hyi family
GO176_RS06655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO176_RS06660	COG2610	gluconate transmembrane transporter activity
GO176_RS06665	COG1522	sequence-specific DNA binding
GO176_RS06670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO176_RS06675	COG0724	RNA recognition motif
GO176_RS06695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO176_RS06715	COG2226	methyltransferase
GO176_RS06720	COG0583	DNA-binding transcription factor activity
GO176_RS06730	COG0513	Belongs to the DEAD box helicase family
GO176_RS06740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO176_RS06755	COG0840	transmembrane signaling receptor activity
GO176_RS06790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GO176_RS06800	COG0259	pyridoxamine-phosphate oxidase activity
GO176_RS06830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GO176_RS06835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GO176_RS06840	COG0840	transmembrane signaling receptor activity
GO176_RS06845	COG0835	chemotaxis
GO176_RS06855	COG0643	Histidine kinase
GO176_RS06855	COG2198	Histidine kinase
GO176_RS06860	COG0745	RESPONSE REGULATOR receiver
GO176_RS06870	COG1444	tRNA N-acetyltransferase activity
GO176_RS06875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO176_RS06905	COG0217	transcriptional regulatory protein
GO176_RS06935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO176_RS06940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO176_RS06945	COG1845	cytochrome c oxidase, subunit III
GO176_RS06950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO176_RS06970	COG0058	SHG alpha-glucan phosphorylase activity
GO176_RS06975	COG1640	4-alpha-glucanotransferase
GO176_RS06990	COG3501	Rhs element vgr protein
GO176_RS07010	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GO176_RS07035	COG0471	metal ion transport
GO176_RS07040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO176_RS07045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GO176_RS07050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GO176_RS07055	COG3033	Beta-eliminating lyase
GO176_RS07065	COG2188	Transcriptional regulator
GO176_RS07070	COG1131	(ABC) transporter
GO176_RS07095	COG3383	formate dehydrogenase (NAD+) activity
GO176_RS07115	COG1132	(ABC) transporter
GO176_RS07125	COG4580	involved in the transport of maltose and maltodextrins
GO176_RS07140	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GO176_RS07145	COG1162	GTPase activity
GO176_RS07170	COG0786	glutamate:sodium symporter activity
GO176_RS07205	COG1566	PFAM secretion protein HlyD family protein
GO176_RS07215	COG3706	GGDEF domain
GO176_RS07230	COG0813	purine-nucleoside phosphorylase activity
GO176_RS07235	COG3272	Protein of unknown function (DUF1722)
GO176_RS07295	COG0513	Belongs to the DEAD box helicase family
GO176_RS07305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO176_RS07310	COG0573	inorganic phosphate transmembrane transporter activity
GO176_RS07315	COG0581	inorganic phosphate transmembrane transporter activity
GO176_RS07325	COG2199	diguanylate cyclase activity
GO176_RS07340	COG0659	secondary active sulfate transmembrane transporter activity
GO176_RS07355	COG0739	heme binding
GO176_RS07360	COG5001	Diguanylate cyclase
GO176_RS07365	COG0583	DNA-binding transcription factor activity
GO176_RS07380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO176_RS07390	COG1764	response to oxidative stress
GO176_RS07395	COG1846	Transcriptional regulator
GO176_RS07400	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO176_RS07420	COG1280	lysine exporter protein (LysE YggA)
GO176_RS07430	COG1902	pentaerythritol trinitrate reductase activity
GO176_RS07435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO176_RS07445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO176_RS07475	COG1612	heme a metabolic process
GO176_RS07480	COG0109	protoheme IX farnesyltransferase activity
GO176_RS07495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO176_RS07505	COG5001	Diguanylate cyclase
GO176_RS07505	COG5002	protein histidine kinase activity
GO176_RS07505	COG3447	MASE1 domain protein
GO176_RS07525	COG1917	Cupin 2, conserved barrel domain protein
GO176_RS07525	COG2207	Transcriptional regulator
GO176_RS07540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO176_RS07545	COG0697	spore germination
GO176_RS07550	COG3477	response to acidic pH
GO176_RS07555	COG3240	lipase activity
GO176_RS07575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GO176_RS07585	COG1349	DNA-binding transcription factor activity
GO176_RS07590	COG0673	inositol 2-dehydrogenase activity
GO176_RS07595	COG4702	Belongs to the UPF0303 family
GO176_RS07605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO176_RS07620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO176_RS07640	COG2814	Major facilitator Superfamily
GO176_RS07645	COG0583	DNA-binding transcription factor activity
GO176_RS07650	COG1902	pentaerythritol trinitrate reductase activity
GO176_RS07655	COG0656	L-ascorbic acid biosynthetic process
GO176_RS07660	COG2200	EAL domain
GO176_RS07670	COG3842	ATPase activity
GO176_RS07700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO176_RS07715	COG2130	NADP-dependent
GO176_RS07720	COG1309	transcriptional regulator
GO176_RS07725	COG0564	pseudouridine synthase activity
GO176_RS07740	COG1846	Transcriptional regulator
GO176_RS07840	COG3501	Rhs element vgr protein
GO176_RS07860	COG1869	D-ribose catabolic process
GO176_RS07865	COG1129	ABC transporter
GO176_RS07870	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO176_RS07875	COG1879	ABC-type sugar transport system periplasmic component
GO176_RS07880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO176_RS07885	COG1609	Transcriptional regulator
GO176_RS07890	COG0583	DNA-binding transcription factor activity
GO176_RS07895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GO176_RS07900	COG0584	glycerophosphoryl diester phosphodiesterase
GO176_RS07905	COG2271	Major facilitator Superfamily
GO176_RS07910	COG5001	Diguanylate cyclase
GO176_RS07910	COG3300	MHYT domain
GO176_RS07930	COG1943	Transposase
GO176_RS07940	COG2188	Transcriptional regulator
GO176_RS07945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO176_RS07945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO176_RS07945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO176_RS07950	COG0383	alpha-mannosidase activity
GO176_RS07955	COG1929	Belongs to the glycerate kinase type-1 family
GO176_RS07965	COG0393	Putative heavy-metal-binding
GO176_RS07970	COG0823	Involved in the tonB-independent uptake of proteins
GO176_RS07975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO176_RS07980	COG0534	Mate efflux family protein
GO176_RS07985	COG3164	Protein of unknown function
GO176_RS07990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO176_RS07995	COG0312	modulator of DNA gyrase
GO176_RS08015	COG0589	response to stress
GO176_RS08035	COG0039	L-malate dehydrogenase activity
GO176_RS08040	COG0531	amino acid
GO176_RS08045	COG0142	geranyltranstransferase activity
GO176_RS08050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO176_RS08055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO176_RS08060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO176_RS08065	COG2966	Psort location CytoplasmicMembrane, score
GO176_RS08080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO176_RS08085	COG2967	ApaG domain
GO176_RS08100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO176_RS08105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GO176_RS08110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO176_RS08160	COG0741	lytic transglycosylase activity
GO176_RS08165	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GO176_RS08190	COG1194	a g-specific adenine glycosylase
GO176_RS08195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO176_RS08205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO176_RS08220	COG1872	DUF167
GO176_RS08230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO176_RS08235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO176_RS08255	COG1678	Uncharacterized ACR, COG1678
GO176_RS08260	COG0189	ligase activity
GO176_RS08265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO176_RS08270	COG2356	endonuclease I
GO176_RS08290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO176_RS08295	COG1943	Transposase
GO176_RS08300	COG0583	DNA-binding transcription factor activity
GO176_RS08305	COG4771	TonB-dependent receptor
GO176_RS08315	COG0126	phosphoglycerate kinase activity
GO176_RS08320	COG0191	fructose-bisphosphate aldolase activity
GO176_RS08325	COG0668	transmembrane transport
GO176_RS08335	COG1279	arginine transmembrane transporter activity
GO176_RS08355	COG0469	pyruvate kinase activity
GO176_RS08360	COG1349	DNA-binding transcription factor activity
GO176_RS08365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO176_RS08370	COG0583	DNA-binding transcription factor activity
GO176_RS08395	COG2239	Acts as a magnesium transporter
GO176_RS08420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO176_RS08430	COG1610	YqeY-like protein
GO176_RS08435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GO176_RS08440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO176_RS08450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO176_RS08455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO176_RS08460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO176_RS08465	COG1968	undecaprenyl-diphosphatase activity
GO176_RS08470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO176_RS08475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO176_RS08485	COG0585	pseudouridine synthase activity
GO176_RS08490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GO176_RS08495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GO176_RS08500	COG1388	LysM domain
GO176_RS08500	COG4942	peptidase
GO176_RS08505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO176_RS08510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GO176_RS08515	COG1546	Belongs to the CinA family
GO176_RS08520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GO176_RS08525	COG2137	regulation of response to DNA damage stimulus
GO176_RS08530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO176_RS08535	COG0527	aspartate kinase activity
GO176_RS08585	COG3630	sodium ion export across plasma membrane
GO176_RS08590	COG5016	pyruvate
GO176_RS08590	COG0511	ligase activity, forming carbon-carbon bonds
GO176_RS08595	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GO176_RS08600	COG1063	alcohol dehydrogenase
GO176_RS08605	COG1238	metal cluster binding
GO176_RS08615	COG2918	glutathione biosynthetic process
GO176_RS08625	COG1854	S-ribosylhomocysteine lyase activity
GO176_RS08630	COG4536	flavin adenine dinucleotide binding
GO176_RS08635	COG4137	Cytochrome C assembly protein
GO176_RS08640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO176_RS08650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO176_RS08660	COG0335	large ribosomal subunit rRNA binding
GO176_RS08665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO176_RS08670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO176_RS08675	COG3105	Protein conserved in bacteria
GO176_RS08680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GO176_RS08690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO176_RS08695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO176_RS08705	COG0723	plastoquinol--plastocyanin reductase activity
GO176_RS08715	COG2857	Cytochrome c1
GO176_RS08720	COG0625	glutathione transferase activity
GO176_RS08725	COG2969	positive regulation of protein catabolic process
GO176_RS08730	COG2823	Periplasmic or secreted lipoprotein
GO176_RS08735	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO176_RS08740	COG0792	nuclease activity
GO176_RS08745	COG3107	peptidoglycan biosynthetic process
GO176_RS08750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO176_RS08760	COG0275	rRNA processing
GO176_RS08765	COG3116	cell division
GO176_RS08770	COG0768	penicillin binding
GO176_RS08775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GO176_RS08780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO176_RS08785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO176_RS08790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO176_RS08795	COG0772	Belongs to the SEDS family
GO176_RS08800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO176_RS08805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO176_RS08810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO176_RS08815	COG0849	cell division
GO176_RS08820	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO176_RS08825	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GO176_RS08835	COG0653	protein targeting
GO176_RS08840	COG0494	nUDIX hydrolase
GO176_RS08850	COG0505	Belongs to the CarA family
GO176_RS08855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO176_RS08865	COG3479	Phenolic acid decarboxylase
GO176_RS08870	COG0730	response to heat
GO176_RS08875	COG0583	DNA-binding transcription factor activity
GO176_RS08895	COG2860	membrane
GO176_RS08900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO176_RS08910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO176_RS08920	COG0493	'glutamate synthase
GO176_RS08925	COG0067	glutamate synthase
GO176_RS08925	COG0069	glutamate synthase activity
GO176_RS08925	COG0070	glutamate synthase
GO176_RS08935	COG0067	glutamate synthase
GO176_RS08935	COG0069	glutamate synthase activity
GO176_RS08935	COG0070	glutamate synthase
GO176_RS08940	COG1242	4 iron, 4 sulfur cluster binding
GO176_RS08945	COG5001	Diguanylate cyclase
GO176_RS08945	COG4251	negative regulation of phosphorylation
GO176_RS08945	COG3706	GGDEF domain
GO176_RS08945	COG2203	Gaf domain
GO176_RS08950	COG0784	Response regulator, receiver
GO176_RS08950	COG5002	protein histidine kinase activity
GO176_RS08950	COG2198	Histidine kinase
GO176_RS08960	COG0745	RESPONSE REGULATOR receiver
GO176_RS08970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO176_RS08985	COG0083	homoserine kinase activity
GO176_RS08990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GO176_RS09005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GO176_RS09020	COG1115	amino acid carrier protein
GO176_RS09035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO176_RS09045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO176_RS09050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO176_RS09055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO176_RS09060	COG0813	purine-nucleoside phosphorylase activity
GO176_RS09070	COG0560	Phosphoserine phosphatase
GO176_RS09085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO176_RS09090	COG0583	DNA-binding transcription factor activity
GO176_RS09100	COG0583	DNA-binding transcription factor activity
GO176_RS09190	COG2059	Chromate
GO176_RS09200	COG2017	converts alpha-aldose to the beta-anomer
GO176_RS09205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO176_RS09235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO176_RS09240	COG2171	N-acyltransferase activity
GO176_RS09245	COG3141	response to X-ray
GO176_RS09250	COG0583	DNA-binding transcription factor activity
GO176_RS09260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GO176_RS09270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO176_RS09280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO176_RS09280	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO176_RS09290	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GO176_RS09295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO176_RS09300	COG2166	iron-sulfur cluster assembly
GO176_RS09305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO176_RS09310	COG0693	protein deglycase activity
GO176_RS09320	COG3248	Nucleoside-binding outer membrane protein
GO176_RS09330	COG1595	DNA-templated transcription, initiation
GO176_RS09340	COG0477	Major facilitator Superfamily
GO176_RS09345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO176_RS09355	COG2974	May be involved in recombination
GO176_RS09360	COG0745	RESPONSE REGULATOR receiver
GO176_RS09365	COG5002	protein histidine kinase activity
GO176_RS09375	COG0248	Ppx GppA phosphatase
GO176_RS09380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GO176_RS09385	COG0573	inorganic phosphate transmembrane transporter activity
GO176_RS09390	COG0581	inorganic phosphate transmembrane transporter activity
GO176_RS09395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO176_RS09400	COG0704	Plays a role in the regulation of phosphate uptake
GO176_RS09410	COG3142	Participates in the control of copper homeostasis
GO176_RS09415	COG0450	alkyl hydroperoxide reductase
GO176_RS09420	COG0583	DNA-binding transcription factor activity
GO176_RS09425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GO176_RS09440	COG0517	IMP dehydrogenase activity
GO176_RS09445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GO176_RS09450	COG0343	queuine tRNA-ribosyltransferase activity
GO176_RS09455	COG1862	Preprotein translocase
GO176_RS09460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO176_RS09465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO176_RS09470	COG1335	isochorismatase
GO176_RS09475	COG0483	inositol monophosphate 1-phosphatase activity
GO176_RS09480	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GO176_RS09485	COG1959	2 iron, 2 sulfur cluster binding
GO176_RS09490	COG1104	cysteine desulfurase activity
GO176_RS09495	COG0822	iron-sulfur transferase activity
GO176_RS09510	COG0443	Heat shock 70 kDa protein
GO176_RS09515	COG0633	Ferredoxin
GO176_RS09520	COG2975	iron-sulfur cluster assembly
GO176_RS09525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO176_RS09545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GO176_RS09550	COG0124	histidyl-tRNA synthetase
GO176_RS09555	COG2976	Protein conserved in bacteria
GO176_RS09560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO176_RS09565	COG1160	GTP binding
GO176_RS09585	COG0516	GMP reductase activity
GO176_RS09585	COG0517	IMP dehydrogenase activity
GO176_RS09590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO176_RS09590	COG0519	Catalyzes the synthesis of GMP from XMP
GO176_RS09600	COG1584	GPR1 FUN34 yaaH family protein
GO176_RS09605	COG3710	Transcriptional regulator
GO176_RS09620	COG3188	usher protein
GO176_RS09625	COG3121	Chaperone
GO176_RS09645	COG1115	amino acid carrier protein
GO176_RS09655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO176_RS09660	COG0583	DNA-binding transcription factor activity
GO176_RS09670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO176_RS09690	COG0582	viral genome integration into host DNA
GO176_RS09700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO176_RS09705	COG2867	negative regulation of translational initiation
GO176_RS09710	COG2914	Belongs to the UPF0125 (RnfH) family
GO176_RS09715	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO176_RS09720	COG0497	DNA recombination
GO176_RS09725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO176_RS09730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO176_RS09740	COG0443	Heat shock 70 kDa protein
GO176_RS09745	COG0484	heat shock protein binding
GO176_RS09775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GO176_RS09780	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GO176_RS09785	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GO176_RS09790	COG0583	DNA-binding transcription factor activity
GO176_RS09795	COG0590	tRNA wobble adenosine to inosine editing
GO176_RS09800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO176_RS09805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO176_RS09805	COG0047	phosphoribosylformylglycinamidine synthase activity
GO176_RS09830	COG0442	prolyl-tRNA aminoacylation
GO176_RS09835	COG1720	tRNA m6t6A37 methyltransferase activity
GO176_RS09840	COG0254	rRNA binding
GO176_RS09845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO176_RS09855	COG1671	Belongs to the UPF0178 family
GO176_RS09880	COG3098	single-species biofilm formation
GO176_RS09885	COG0564	pseudouridine synthase activity
GO176_RS09890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO176_RS09895	COG0142	geranyltranstransferase activity
GO176_RS09905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO176_RS09915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO176_RS09915	COG0301	tRNA thio-modification
GO176_RS09920	COG0583	DNA-binding transcription factor activity
GO176_RS09930	COG2363	Small membrane protein
GO176_RS09940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO176_RS09950	COG3706	GGDEF domain
GO176_RS09950	COG0745	RESPONSE REGULATOR receiver
GO176_RS09960	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO176_RS09960	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO176_RS09970	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GO176_RS09975	COG1464	Belongs to the NlpA lipoprotein family
GO176_RS09980	COG2011	ABC-type metal ion transport system permease component
GO176_RS09985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO176_RS09990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO176_RS10005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO176_RS10005	COG1263	PTS System
GO176_RS10010	COG0366	Alpha amylase catalytic
GO176_RS10015	COG2271	Major facilitator Superfamily
GO176_RS10025	COG2197	response regulator
GO176_RS10055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO176_RS10060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO176_RS10080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO176_RS10085	COG0321	lipoyl(octanoyl) transferase activity
GO176_RS10090	COG2921	Belongs to the UPF0250 family
GO176_RS10095	COG1686	Belongs to the peptidase S11 family
GO176_RS10100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO176_RS10105	COG0772	Belongs to the SEDS family
GO176_RS10110	COG0768	penicillin binding
GO176_RS10115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO176_RS10120	COG0799	negative regulation of ribosome biogenesis
GO176_RS10125	COG1466	dna polymerase III delta subunit
GO176_RS10130	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GO176_RS10135	COG0495	leucyl-tRNA aminoacylation
GO176_RS10140	COG2888	peptidyl-tyrosine sulfation
GO176_RS10145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GO176_RS10155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO176_RS10160	COG1702	phosphate starvation-inducible protein PhoH
GO176_RS10165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO176_RS10170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO176_RS10175	COG2190	(PTS) system
GO176_RS10185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO176_RS10190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO176_RS10195	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GO176_RS10200	COG3115	cell septum assembly
GO176_RS10205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO176_RS10220	COG0789	Transcriptional regulator
GO176_RS10235	COG3118	belongs to the thioredoxin family
GO176_RS10240	COG0300	oxidoreductase activity
GO176_RS10270	COG0622	Phosphoesterase
GO176_RS10285	COG3710	Transcriptional regulator
GO176_RS10290	COG0326	Molecular chaperone. Has ATPase activity
GO176_RS10300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GO176_RS10315	COG0367	asparagine synthase
GO176_RS10320	COG4651	solute:proton antiporter activity
GO176_RS10320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO176_RS10325	COG1846	Transcriptional regulator
GO176_RS10325	COG1940	carbohydrate kinase activity
GO176_RS10330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO176_RS10335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO176_RS10335	COG1263	PTS System
GO176_RS10335	COG2190	(PTS) system
GO176_RS10340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO176_RS10350	COG1943	Transposase
GO176_RS10355	COG0101	tRNA pseudouridine synthase activity
GO176_RS10365	COG0285	dihydrofolate synthase activity
GO176_RS10370	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GO176_RS10375	COG1286	toxin biosynthetic process
GO176_RS10380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO176_RS10385	COG2056	Na+-H+ antiporter family
GO176_RS10390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO176_RS10405	COG0346	lactoylglutathione lyase activity
GO176_RS10410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO176_RS10415	COG4660	Part of a membrane complex involved in electron transport
GO176_RS10420	COG4659	FMN binding
GO176_RS10430	COG4656	Part of a membrane complex involved in electron transport
GO176_RS10435	COG2878	Part of a membrane complex involved in electron transport
GO176_RS10440	COG4657	Part of a membrane complex involved in electron transport
GO176_RS10445	COG1882	Formate acetyltransferase
GO176_RS10460	COG2204	response regulator
GO176_RS10465	COG2198	Histidine kinase
GO176_RS10470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GO176_RS10475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO176_RS10480	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO176_RS10485	COG0315	cyclic pyranopterin monophosphate synthase activity
GO176_RS10490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GO176_RS10495	COG0314	molybdopterin synthase activity
GO176_RS10500	COG3706	GGDEF domain
GO176_RS10505	COG0517	IMP dehydrogenase activity
GO176_RS10505	COG0516	GMP reductase activity
GO176_RS10515	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GO176_RS10525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO176_RS10525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO176_RS10535	COG0572	uridine kinase
GO176_RS10540	COG2982	Protein involved in outer membrane biogenesis
GO176_RS10545	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GO176_RS10560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO176_RS10565	COG2067	long-chain fatty acid transport protein
GO176_RS10585	COG0183	Belongs to the thiolase family
GO176_RS10590	COG1024	Enoyl-CoA hydratase
GO176_RS10590	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO176_RS10595	COG0778	Nitroreductase
GO176_RS10600	COG0583	DNA-binding transcription factor activity
GO176_RS10615	COG2832	Protein of unknown function (DUF454)
GO176_RS10620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO176_RS10630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO176_RS10635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO176_RS10640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO176_RS10665	COG2226	methyltransferase
GO176_RS10670	COG0676	glucose-6-phosphate 1-epimerase activity
GO176_RS10675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO176_RS10680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO176_RS10695	COG0252	asparaginase activity
GO176_RS10710	COG0788	formyltetrahydrofolate deformylase activity
GO176_RS10725	COG1214	PFAM Peptidase M22, glycoprotease
GO176_RS10740	COG2267	carboxylic ester hydrolase activity
GO176_RS10745	COG0318	PFAM AMP-dependent synthetase and ligase
GO176_RS10750	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GO176_RS10760	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GO176_RS10765	COG2894	cell division
GO176_RS10770	COG0850	regulation of cytokinetic process
GO176_RS10775	COG3100	YcgL domain-containing protein
GO176_RS10790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO176_RS10795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO176_RS10810	COG0732	type I restriction modification DNA specificity domain
GO176_RS10835	COG3842	ATPase activity
GO176_RS10845	COG1840	ABC-type Fe3 transport system, periplasmic component
GO176_RS10850	COG2271	Major facilitator Superfamily
GO176_RS10855	COG3851	Histidine kinase
GO176_RS10860	COG2197	response regulator
GO176_RS10895	COG4589	Belongs to the CDS family
GO176_RS10915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO176_RS10915	COG3153	acetyltransferase
GO176_RS10925	COG1760	l-serine dehydratase
GO176_RS10930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GO176_RS10935	COG0745	RESPONSE REGULATOR receiver
GO176_RS10955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO176_RS10960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GO176_RS10965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GO176_RS10975	COG4191	Histidine kinase
GO176_RS10980	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO176_RS10990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO176_RS10995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO176_RS11000	COG0776	regulation of translation
GO176_RS11005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO176_RS11010	COG1555	photosystem II stabilization
GO176_RS11015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO176_RS11020	COG0539	negative regulation of cytoplasmic translation
GO176_RS11030	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GO176_RS11035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GO176_RS11065	COG0686	Belongs to the AlaDH PNT family
GO176_RS11070	COG1522	sequence-specific DNA binding
GO176_RS11075	COG1674	ftsk spoiiie
GO176_RS11080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO176_RS11085	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO176_RS11090	COG2186	Transcriptional regulator
GO176_RS11105	COG0537	adenosine 5'-monophosphoramidase activity
GO176_RS11135	COG1252	NADH dehydrogenase
GO176_RS11160	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO176_RS11165	COG1136	(ABC) transporter
GO176_RS11180	COG0658	competence protein
GO176_RS11180	COG2333	competence protein COMEC
GO176_RS11185	COG1132	(ABC) transporter
GO176_RS11190	COG1663	tetraacyldisaccharide 4'-kinase activity
GO176_RS11200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GO176_RS11205	COG2719	SpoVR family
GO176_RS11220	COG3713	MltA-interacting MipA family protein
GO176_RS11235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO176_RS11250	COG1882	Formate acetyltransferase
GO176_RS11270	COG4215	(ABC) transporter
GO176_RS11275	COG4160	amino acid transport
GO176_RS11280	COG0708	Exodeoxyribonuclease III
GO176_RS11295	COG3923	Primosomal replication protein n
GO176_RS11300	COG1199	ATP-dependent helicase activity
GO176_RS11305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GO176_RS11315	COG3012	SEC-C Motif Domain Protein
GO176_RS11320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO176_RS11325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO176_RS11330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO176_RS11335	COG0215	cysteine-tRNA ligase activity
GO176_RS11340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GO176_RS11350	COG2255	four-way junction helicase activity
GO176_RS11360	COG1294	oxidase, subunit
GO176_RS11365	COG4890	Cyd operon protein YbgT
GO176_RS11375	COG0824	Thioesterase
GO176_RS11400	COG2885	chlorophyll binding
GO176_RS11405	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GO176_RS11420	COG0784	Response regulator, receiver
GO176_RS11420	COG5002	protein histidine kinase activity
GO176_RS11435	COG1349	DNA-binding transcription factor activity
GO176_RS11440	COG1349	DNA-binding transcription factor activity
GO176_RS11450	COG2222	sugar isomerase
GO176_RS11455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO176_RS11465	COG3716	PTS system mannose fructose sorbose family IID component
GO176_RS11470	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO176_RS11480	COG0191	fructose-bisphosphate aldolase activity
GO176_RS11495	COG3366	ferrous iron transmembrane transporter activity
GO176_RS11500	COG0700	Nucleoside recognition
GO176_RS11510	COG1012	belongs to the aldehyde dehydrogenase family
GO176_RS11530	COG1960	acyl-CoA dehydrogenase activity
GO176_RS11535	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO176_RS11545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO176_RS11555	COG1737	Transcriptional regulator
GO176_RS11560	COG0076	glutamate decarboxylase activity
GO176_RS11580	COG3070	regulator of competence-specific genes
GO176_RS11595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO176_RS11595	COG4191	Histidine kinase
GO176_RS11605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GO176_RS11625	COG3940	Belongs to the glycosyl hydrolase 43 family
GO176_RS11630	COG2211	Major facilitator Superfamily
GO176_RS11635	COG1032	radical SAM domain protein
GO176_RS11640	COG0488	(ABC) transporter
GO176_RS11670	COG0840	transmembrane signaling receptor activity
GO176_RS11675	COG2200	EAL domain
GO176_RS11675	COG2771	luxR family
GO176_RS11690	COG0612	Peptidase, M16
GO176_RS11705	COG0583	DNA-binding transcription factor activity
GO176_RS11730	COG1987	bacterial-type flagellum assembly
GO176_RS11740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO176_RS11750	COG1815	bacterial-type flagellum-dependent cell motility
GO176_RS11755	COG1558	bacterial-type flagellum-dependent cell motility
GO176_RS11760	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO176_RS11765	COG1749	Flagellar hook protein flgE
GO176_RS11775	COG4786	Flagellar basal body rod
GO176_RS11780	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO176_RS11785	COG1706	bacterial-type flagellum-dependent cell motility
GO176_RS11810	COG1677	Flagellar hook-basal body complex protein FliE
GO176_RS11820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO176_RS11850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO176_RS11855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO176_RS11860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO176_RS11865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GO176_RS11895	COG1191	sigma factor activity
GO176_RS11900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO176_RS11905	COG1360	Flagellar Motor Protein
GO176_RS11915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO176_RS11930	COG2350	Protein conserved in bacteria
GO176_RS11935	COG1607	acyl-coa hydrolase
GO176_RS11945	COG1301	dicarboxylic acid transport
GO176_RS11955	COG0133	tryptophan synthase activity
GO176_RS11960	COG0134	indole-3-glycerol-phosphate synthase activity
GO176_RS11960	COG0135	phosphoribosylanthranilate isomerase activity
GO176_RS11965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO176_RS11970	COG0512	Glutamine amidotransferase of anthranilate synthase
GO176_RS11975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO176_RS11985	COG0613	PHP domain protein
GO176_RS12000	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GO176_RS12020	COG0800	Aldolase
GO176_RS12030	COG0009	L-threonylcarbamoyladenylate synthase
GO176_RS12035	COG1187	pseudouridine synthase activity
GO176_RS12040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO176_RS12045	COG0210	DNA helicase
GO176_RS12055	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GO176_RS12060	COG4988	ABC transporter
GO176_RS12065	COG0492	ferredoxin-NADP+ reductase activity
GO176_RS12095	COG2949	membrane
GO176_RS12120	COG0583	DNA-binding transcription factor activity
GO176_RS12130	COG0281	malic enzyme
GO176_RS12150	COG0583	DNA-binding transcription factor activity
GO176_RS12165	COG1757	Na H antiporter
GO176_RS12170	COG0174	glutamine synthetase
GO176_RS12175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GO176_RS12180	COG1917	Cupin 2, conserved barrel domain protein
GO176_RS12180	COG1396	sequence-specific DNA binding
GO176_RS12185	COG1012	belongs to the aldehyde dehydrogenase family
GO176_RS12190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO176_RS12200	COG2957	Belongs to the agmatine deiminase family
GO176_RS12235	COG2885	chlorophyll binding
GO176_RS12255	COG0247	lactate metabolic process
GO176_RS12255	COG0277	FAD linked oxidase domain protein
GO176_RS12275	COG2986	histidine ammonia-lyase
GO176_RS12285	COG0010	Belongs to the arginase family
GO176_RS12290	COG1228	amidohydrolase
GO176_RS12310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO176_RS12320	COG0417	DNA replication proofreading
GO176_RS12325	COG2197	response regulator
GO176_RS12360	COG2133	pyrroloquinoline quinone binding
GO176_RS12370	COG3706	GGDEF domain
GO176_RS12370	COG0745	RESPONSE REGULATOR receiver
GO176_RS12385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO176_RS12390	COG0072	phenylalanine-tRNA ligase activity
GO176_RS12390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO176_RS12395	COG0776	regulation of translation
GO176_RS12405	COG0500	methyltransferase
GO176_RS12415	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GO176_RS12435	COG5001	Diguanylate cyclase
GO176_RS12440	COG0295	cytidine deaminase activity
GO176_RS12445	COG1346	cytolysis
GO176_RS12455	COG2925	Exonuclease
GO176_RS12495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO176_RS12500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GO176_RS12505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GO176_RS12520	COG2988	succinylglutamate desuccinylase activity
GO176_RS12525	COG4139	cobalamin transport
GO176_RS12530	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GO176_RS12600	COG4964	Belongs to the GSP D family
GO176_RS12645	COG1609	Transcriptional regulator
GO176_RS12655	COG2182	Extracellular solute-binding protein
GO176_RS12660	COG1175	transmembrane transport
GO176_RS12665	COG3833	ABC-type maltose transport systems, permease component
GO176_RS12675	COG1874	Beta-galactosidase
GO176_RS12685	COG0840	transmembrane signaling receptor activity
GO176_RS12690	COG0110	maltose O-acetyltransferase activity
GO176_RS12715	COG0583	DNA-binding transcription factor activity
GO176_RS12725	COG1451	nucleotide metabolic process
GO176_RS12740	COG3063	Type IV pilus biogenesis stability protein PilW
GO176_RS12745	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO176_RS12765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO176_RS12780	COG3290	protein histidine kinase activity
GO176_RS12785	COG4565	transcriptional regulatory protein
GO176_RS12795	COG0784	Response regulator, receiver
GO176_RS12795	COG0835	chemotaxis
GO176_RS12805	COG1921	L-seryl-tRNASec selenium transferase activity
GO176_RS12815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO176_RS12820	COG0651	ATP synthesis coupled electron transport
GO176_RS12825	COG0650	Formate hydrogenlyase subunit 4
GO176_RS12830	COG3261	NADH dehydrogenase
GO176_RS12830	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GO176_RS12835	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO176_RS12840	COG3260	NADH ubiquinone oxidoreductase 20
GO176_RS12850	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO176_RS12855	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO176_RS12865	COG3604	Transcriptional regulator
GO176_RS12870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO176_RS12880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GO176_RS12885	COG0298	carbon dioxide binding
GO176_RS12895	COG0309	Hydrogenase expression formation protein (HypE)
GO176_RS12900	COG0375	protein maturation
GO176_RS12905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GO176_RS12910	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GO176_RS12915	COG2897	thiosulfate sulfurtransferase activity
GO176_RS12930	COG0745	RESPONSE REGULATOR receiver
GO176_RS12930	COG3706	GGDEF domain
GO176_RS12970	COG4386	tail sheath protein
GO176_RS13010	COG4695	Portal protein
GO176_RS13015	COG2184	nucleotidyltransferase activity
GO176_RS13170	COG4974	Belongs to the 'phage' integrase family
GO176_RS13190	COG0668	transmembrane transport
GO176_RS13210	COG0745	RESPONSE REGULATOR receiver
GO176_RS13215	COG5002	protein histidine kinase activity
GO176_RS13220	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GO176_RS13240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO176_RS13255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO176_RS13260	COG1254	Belongs to the acylphosphatase family
GO176_RS13265	COG2920	part of a sulfur-relay system
GO176_RS13270	COG0670	Belongs to the BI1 family
GO176_RS13275	COG1126	abc transporter atp-binding protein
GO176_RS13280	COG0765	amino acid transport
GO176_RS13285	COG4597	amino acid ABC transporter
GO176_RS13290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO176_RS13300	COG0561	phosphatase activity
GO176_RS13305	COG0602	queuosine metabolic process
GO176_RS13310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GO176_RS13315	COG3005	denitrification pathway
GO176_RS13320	COG0243	molybdopterin cofactor binding
GO176_RS13325	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GO176_RS13335	COG2999	glutathione oxidoreductase activity
GO176_RS13360	COG3706	GGDEF domain
GO176_RS13365	COG0443	Heat shock 70 kDa protein
GO176_RS13380	COG3706	GGDEF domain
GO176_RS13410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO176_RS13415	COG1643	Atp-dependent helicase
GO176_RS13450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO176_RS13460	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO176_RS13475	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GO176_RS13480	COG4638	Rieske (2fe-2S)
GO176_RS13485	COG0583	DNA-binding transcription factor activity
GO176_RS13490	COG1414	Transcriptional regulator
GO176_RS13505	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GO176_RS13515	COG3501	Rhs element vgr protein
GO176_RS13540	COG1115	amino acid carrier protein
GO176_RS13555	COG1943	Transposase
GO176_RS13560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO176_RS13570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO176_RS13590	COG2996	Protein conserved in bacteria
GO176_RS13595	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GO176_RS13595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO176_RS13600	COG3008	intermembrane lipid transfer
GO176_RS13605	COG2995	paraquat-inducible protein a
GO176_RS13610	COG1132	(ABC) transporter
GO176_RS13615	COG1956	GAF domain-containing protein
GO176_RS13620	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GO176_RS13640	COG0308	aminopeptidase N
GO176_RS13650	COG2902	Dehydrogenase
GO176_RS13665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO176_RS13665	COG0116	Belongs to the methyltransferase superfamily
GO176_RS13675	COG0488	(ABC) transporter
GO176_RS13690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO176_RS13695	COG1067	ATP-dependent peptidase activity
GO176_RS13700	COG3120	sequence-specific DNA binding
GO176_RS13735	COG3278	Belongs to the heme-copper respiratory oxidase family
GO176_RS13750	COG2010	Cytochrome c
GO176_RS13760	COG2217	Heavy metal translocating P-type atpase
GO176_RS13775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO176_RS13780	COG0589	response to stress
GO176_RS13805	COG3842	ATPase activity
GO176_RS13810	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO176_RS13815	COG1177	transmembrane transport
GO176_RS13820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO176_RS13825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO176_RS13830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO176_RS13835	COG0004	ammonium transporteR
GO176_RS13850	COG0437	4 iron, 4 sulfur cluster binding
GO176_RS13865	COG3381	protein complex oligomerization
GO176_RS13885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO176_RS13900	COG3852	Histidine kinase
GO176_RS13905	COG2204	response regulator
GO176_RS13915	COG4662	Binding-protein-dependent transport system inner membrane component
GO176_RS13920	COG3842	ATPase activity
GO176_RS13925	COG0746	molybdenum cofactor guanylyltransferase activity
GO176_RS13960	COG0791	NLP P60 protein
GO176_RS13980	COG0307	riboflavin synthase, alpha
GO176_RS13995	COG1793	dna ligase
GO176_RS14000	COG4667	esterase of the alpha-beta hydrolase superfamily
GO176_RS14020	COG0848	biopolymer transport protein
GO176_RS14025	COG0811	peptide transport
GO176_RS14030	COG0811	peptide transport
GO176_RS14040	COG3040	lipid binding
GO176_RS14045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO176_RS14060	COG1175	transmembrane transport
GO176_RS14065	COG0395	ABC-type sugar transport system, permease component
GO176_RS14070	COG3842	ATPase activity
GO176_RS14075	COG1349	DNA-binding transcription factor activity
GO176_RS14085	COG2731	YhcH YjgK YiaL family protein
GO176_RS14105	COG0625	glutathione transferase activity
GO176_RS14115	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GO176_RS14125	COG2200	EAL domain
GO176_RS14130	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO176_RS14150	COG2814	Major facilitator Superfamily
GO176_RS14155	COG1566	PFAM secretion protein HlyD family protein
GO176_RS14175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GO176_RS14180	COG0372	Belongs to the citrate synthase family
GO176_RS14185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GO176_RS14195	COG2169	Transcriptional regulator
GO176_RS14195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO176_RS14230	COG1129	ABC transporter
GO176_RS14240	COG3250	beta-galactosidase activity
GO176_RS14250	COG2991	Protein conserved in bacteria
GO176_RS14255	COG0778	Nitroreductase
GO176_RS14260	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO176_RS14300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO176_RS14305	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GO176_RS14315	COG3106	COG3106 Predicted ATPase
GO176_RS14330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO176_RS14335	COG0784	Response regulator, receiver
GO176_RS14335	COG2205	protein histidine kinase activity
GO176_RS14345	COG0494	nUDIX hydrolase
GO176_RS14350	COG0814	amino acid
GO176_RS14355	COG1760	l-serine dehydratase
GO176_RS14360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO176_RS14365	COG1136	(ABC) transporter
GO176_RS14365	COG0577	efflux transmembrane transporter activity
GO176_RS14385	COG0720	synthase
GO176_RS14395	COG0017	Asparaginyl-tRNA synthetase
GO176_RS14410	COG1448	Aminotransferase
GO176_RS14425	COG2176	DNA-directed DNA polymerase activity
GO176_RS14430	COG0840	transmembrane signaling receptor activity
GO176_RS14435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO176_RS14465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO176_RS14480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO176_RS14485	COG3108	Peptidase M15
GO176_RS14490	COG2989	Protein conserved in bacteria
GO176_RS14515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO176_RS14530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO176_RS14535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO176_RS14565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO176_RS14570	COG3265	gluconokinase activity
GO176_RS14585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GO176_RS14645	COG4181	ATPase activity
GO176_RS14650	COG0534	Mate efflux family protein
GO176_RS14655	COG0702	epimerase
GO176_RS14665	COG2814	Major facilitator Superfamily
GO176_RS14675	COG1061	Type III restriction enzyme res subunit
GO176_RS14685	COG0745	RESPONSE REGULATOR receiver
GO176_RS14690	COG0642	Histidine kinase
GO176_RS14695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO176_RS14725	COG0679	Auxin Efflux Carrier
GO176_RS14740	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GO176_RS14755	COG3153	acetyltransferase
GO176_RS14785	COG1278	Cold shock
GO176_RS14790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO176_RS14800	COG0814	amino acid
GO176_RS14810	COG1131	(ABC) transporter
GO176_RS14815	COG0842	Transport permease protein
GO176_RS14825	COG3313	Fe-S protein
GO176_RS14835	COG4134	Bacterial extracellular solute-binding protein
GO176_RS14840	COG4135	transport system, permease component
GO176_RS14845	COG4136	ATPase activity
GO176_RS14850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO176_RS14855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO176_RS14865	COG0564	pseudouridine synthase activity
GO176_RS14875	COG0733	neurotransmitter:sodium symporter activity
GO176_RS14885	COG0626	cystathionine gamma-synthase activity
GO176_RS14890	COG2818	Glycosylase
GO176_RS14905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO176_RS14920	COG1842	Phage shock protein A
GO176_RS14925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO176_RS14935	COG4168	peptide transport system, permease
GO176_RS14940	COG4171	peptide transport system, permease
GO176_RS14950	COG4172	Belongs to the ABC transporter superfamily
GO176_RS14965	COG1227	inorganic diphosphatase activity
GO176_RS14985	COG0243	molybdopterin cofactor binding
GO176_RS14990	COG3005	denitrification pathway
GO176_RS14995	COG4459	periplasmic nitrate reductase
GO176_RS15000	COG0390	transport system, permease component
GO176_RS15005	COG2116	formate transmembrane transporter activity
GO176_RS15020	COG0583	DNA-binding transcription factor activity
GO176_RS15025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO176_RS15030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GO176_RS15035	COG1435	thymidine kinase activity
GO176_RS15045	COG1801	Protein of unknown function DUF72
GO176_RS15050	COG4106	trans-aconitate 2-methyltransferase activity
GO176_RS15055	COG0500	methyltransferase
GO176_RS15060	COG0189	ligase activity
GO176_RS15060	COG4067	protein conserved in archaea
GO176_RS15075	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GO176_RS15080	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GO176_RS15085	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GO176_RS15090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO176_RS15100	COG0745	RESPONSE REGULATOR receiver
GO176_RS15105	COG3381	protein complex oligomerization
GO176_RS15110	COG1609	Transcriptional regulator
GO176_RS15115	COG3070	regulator of competence-specific genes
GO176_RS15135	COG0297	glycogen (starch) synthase activity
GO176_RS15140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO176_RS15145	COG0745	RESPONSE REGULATOR receiver
GO176_RS15145	COG3706	GGDEF domain
GO176_RS15150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO176_RS15170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GO176_RS15180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GO176_RS15190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GO176_RS15195	COG1278	Cold shock
GO176_RS15205	COG2223	nitrite transmembrane transporter activity
GO176_RS15210	COG1695	Transcriptional regulator
GO176_RS15220	COG1187	pseudouridine synthase activity
GO176_RS15225	COG0140	phosphoribosyl-ATP diphosphatase activity
GO176_RS15225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO176_RS15235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO176_RS15240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO176_RS15245	COG0131	Imidazoleglycerol-phosphate dehydratase
GO176_RS15245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO176_RS15250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO176_RS15255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO176_RS15260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO176_RS15270	COG1757	Na H antiporter
GO176_RS15275	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO176_RS15280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO176_RS15285	COG0482	sulfurtransferase activity
GO176_RS15290	COG2915	High frequency lysogenization protein hflD homolog
GO176_RS15295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO176_RS15315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO176_RS15330	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS15340	COG0501	Belongs to the peptidase M48B family
GO176_RS15345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GO176_RS15350	COG2226	methyltransferase
GO176_RS15360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO176_RS15365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO176_RS15375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO176_RS15375	COG2146	nitrite reductase [NAD(P)H] activity
GO176_RS15385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO176_RS15390	COG1116	anion transmembrane transporter activity
GO176_RS15390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO176_RS15405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO176_RS15405	COG1648	precorrin-2 dehydrogenase activity
GO176_RS15410	COG0243	molybdopterin cofactor binding
GO176_RS15420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO176_RS15425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO176_RS15430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO176_RS15435	COG0653	protein targeting
GO176_RS15440	COG2165	general secretion pathway protein
GO176_RS15450	COG3706	GGDEF domain
GO176_RS15460	COG4120	Belongs to the binding-protein-dependent transport system permease family
GO176_RS15470	COG3092	negative regulation of chromosome organization
GO176_RS15475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO176_RS15485	COG3174	membrane
GO176_RS15490	COG0435	Glutathione S-transferase
GO176_RS15505	COG0444	Belongs to the ABC transporter superfamily
GO176_RS15510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO176_RS15515	COG0601	transmembrane transport
GO176_RS15545	COG0204	Acyl-transferase
GO176_RS15545	COG0318	PFAM AMP-dependent synthetase and ligase
GO176_RS15550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO176_RS15555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO176_RS15580	COG2986	histidine ammonia-lyase
GO176_RS15605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO176_RS15615	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS15630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO176_RS15640	COG2203	Gaf domain
GO176_RS15640	COG3706	GGDEF domain
GO176_RS15640	COG4251	negative regulation of phosphorylation
GO176_RS15640	COG5001	Diguanylate cyclase
GO176_RS15645	COG1621	beta-fructofuranosidase activity
GO176_RS15655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO176_RS15655	COG1263	PTS System
GO176_RS15665	COG0745	RESPONSE REGULATOR receiver
GO176_RS15675	COG2207	Transcriptional regulator
GO176_RS15675	COG3708	Transcriptional regulator
GO176_RS15680	COG2814	Major facilitator Superfamily
GO176_RS15685	COG1566	PFAM secretion protein HlyD family protein
GO176_RS15690	COG1538	Outer membrane efflux protein
GO176_RS15700	COG0747	negative chemotaxis
GO176_RS15705	COG0601	transmembrane transport
GO176_RS15710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO176_RS15715	COG4172	Belongs to the ABC transporter superfamily
GO176_RS15725	COG1741	Belongs to the pirin family
GO176_RS15730	COG2723	6-phospho-beta-galactosidase activity
GO176_RS15735	COG1609	Transcriptional regulator
GO176_RS15745	COG1120	ATPase activity
GO176_RS15750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO176_RS15760	COG1629	transport
GO176_RS15760	COG4774	siderophore transport
GO176_RS15765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO176_RS15775	COG4592	Periplasmic binding protein
GO176_RS15790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO176_RS15790	COG3433	isochorismatase activity
GO176_RS15790	COG2226	methyltransferase
GO176_RS15795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO176_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS15805	COG1169	isochorismate synthase
GO176_RS15810	COG1021	2,3-dihydroxybenzoate-AMP ligase
GO176_RS15825	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO176_RS15840	COG3275	phosphorelay sensor kinase activity
GO176_RS15845	COG3279	Response regulator of the LytR AlgR family
GO176_RS15875	COG1294	oxidase, subunit
GO176_RS15880	COG1271	oxidase subunit
GO176_RS15885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO176_RS15920	COG4566	intracellular signal transduction
GO176_RS15925	COG2194	sulfuric ester hydrolase activity
GO176_RS15930	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO176_RS15935	COG1368	sulfuric ester hydrolase activity
GO176_RS15940	COG0513	Belongs to the DEAD box helicase family
GO176_RS15960	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO176_RS15965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO176_RS15985	COG2207	Transcriptional regulator
GO176_RS15990	COG1881	PFAM PEBP family protein
GO176_RS16015	COG2723	6-phospho-beta-galactosidase activity
GO176_RS16025	COG3711	transcriptional antiterminator
GO176_RS16035	COG0583	DNA-binding transcription factor activity
GO176_RS16045	COG5001	Diguanylate cyclase
GO176_RS16045	COG5002	protein histidine kinase activity
GO176_RS16060	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GO176_RS16065	COG1946	Acyl-CoA thioesterase
GO176_RS16070	COG1522	sequence-specific DNA binding
GO176_RS16110	COG2204	response regulator
GO176_RS16115	COG3047	cAMP biosynthetic process
GO176_RS16115	COG2885	chlorophyll binding
GO176_RS16135	COG1987	bacterial-type flagellum assembly
GO176_RS16145	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO176_RS16160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO176_RS16165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GO176_RS16185	COG1580	Controls the rotational direction of flagella during chemotaxis
GO176_RS16190	COG1191	sigma factor activity
GO176_RS16195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO176_RS16200	COG1360	Flagellar Motor Protein
GO176_RS16210	COG3015	lipoprotein NlpE involved in copper resistance
GO176_RS16255	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GO176_RS16310	COG1706	bacterial-type flagellum-dependent cell motility
GO176_RS16315	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO176_RS16320	COG4786	Flagellar basal body rod
GO176_RS16330	COG1749	Flagellar hook protein flgE
GO176_RS16335	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO176_RS16340	COG1558	bacterial-type flagellum-dependent cell motility
GO176_RS16345	COG1815	bacterial-type flagellum-dependent cell motility
GO176_RS16365	COG1388	LysM domain
GO176_RS16365	COG0741	lytic transglycosylase activity
GO176_RS16390	COG0477	Major facilitator Superfamily
GO176_RS16395	COG2855	membrane
GO176_RS16410	COG1441	menaquinone biosynthetic process
GO176_RS16415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO176_RS16425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GO176_RS16435	COG0436	Aminotransferase
GO176_RS16440	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GO176_RS16445	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GO176_RS16465	COG0616	signal peptide processing
GO176_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS16485	COG0587	DNA-directed DNA polymerase activity
GO176_RS16490	COG0835	chemotaxis
GO176_RS16490	COG0784	Response regulator, receiver
GO176_RS16495	COG1940	carbohydrate kinase activity
GO176_RS16500	COG0469	pyruvate kinase activity
GO176_RS16520	COG0733	neurotransmitter:sodium symporter activity
GO176_RS16535	COG1263	PTS System
GO176_RS16535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO176_RS16550	COG0084	hydrolase, TatD family'
GO176_RS16560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO176_RS16565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO176_RS16570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO176_RS16575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO176_RS16595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO176_RS16600	COG0416	fatty acid biosynthetic process
GO176_RS16615	COG0424	maF-like protein
GO176_RS16620	COG0564	pseudouridine synthase activity
GO176_RS16625	COG1530	ribonuclease E activity
GO176_RS16635	COG0659	secondary active sulfate transmembrane transporter activity
GO176_RS16645	COG1943	Transposase
GO176_RS16650	COG1012	belongs to the aldehyde dehydrogenase family
GO176_RS16650	COG1454	alcohol dehydrogenase
GO176_RS16655	COG2095	MarC family integral membrane protein
GO176_RS16660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO176_RS16665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO176_RS16670	COG1757	Na H antiporter
GO176_RS16690	COG3083	sulfuric ester hydrolase activity
GO176_RS16705	COG2814	Major facilitator Superfamily
GO176_RS16735	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO176_RS16750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO176_RS16790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO176_RS16795	COG2159	amidohydrolase
GO176_RS16800	COG0583	DNA-binding transcription factor activity
GO176_RS16815	COG0667	Aldo Keto reductase
GO176_RS16840	COG3384	dioxygenase
GO176_RS16845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO176_RS16850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GO176_RS16870	COG2853	Lipoprotein
GO176_RS16885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO176_RS16890	COG1138	Cytochrome C-type biogenesis protein
GO176_RS16900	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO176_RS16905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO176_RS16910	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO176_RS16925	COG0835	chemotaxis
GO176_RS16935	COG1192	Involved in chromosome partitioning
GO176_RS16945	COG2198	Histidine kinase
GO176_RS16945	COG0643	Histidine kinase
GO176_RS16950	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GO176_RS16965	COG0455	bacterial-type flagellum organization
GO176_RS16980	COG2062	phosphohistidine phosphatase, SixA
GO176_RS16990	COG3102	Protein conserved in bacteria
GO176_RS17015	COG1918	ferrous iron import across plasma membrane
GO176_RS17020	COG2207	Transcriptional regulator
GO176_RS17025	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GO176_RS17030	COG1121	(ABC) transporter
GO176_RS17035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO176_RS17050	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO176_RS17055	COG0567	Dehydrogenase, E1 component
GO176_RS17065	COG1053	succinate dehydrogenase
GO176_RS17070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GO176_RS17075	COG2009	succinate dehydrogenase
GO176_RS17085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO176_RS17095	COG0033	Phosphoglucomutase
GO176_RS17100	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GO176_RS17105	COG0596	Alpha beta hydrolase
GO176_RS17120	COG1346	cytolysis
GO176_RS17125	COG1380	Effector of murein hydrolase LrgA
GO176_RS17130	COG0583	DNA-binding transcription factor activity
GO176_RS17140	COG0735	belongs to the Fur family
GO176_RS17145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO176_RS17155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO176_RS17160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO176_RS17160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GO176_RS17175	COG3101	peptidyl-lysine hydroxylation
GO176_RS17180	COG2860	membrane
GO176_RS17185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO176_RS17190	COG2890	protein-(glutamine-N5) methyltransferase activity
GO176_RS17210	COG1987	bacterial-type flagellum assembly
GO176_RS17260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO176_RS17270	COG1677	Flagellar hook-basal body complex protein FliE
GO176_RS17275	COG2204	response regulator
GO176_RS17280	COG4191	Histidine kinase
GO176_RS17285	COG2204	response regulator
GO176_RS17290	COG1516	flagellar protein fliS
GO176_RS17300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GO176_RS17305	COG1334	flagellar protein FlaG
GO176_RS17310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO176_RS17325	COG2837	iron assimilation
GO176_RS17345	COG0516	GMP reductase activity
GO176_RS17345	COG0517	IMP dehydrogenase activity
GO176_RS17360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO176_RS17365	COG1085	galactose-1-phosphate uridylyltransferase
GO176_RS17370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO176_RS17380	COG1393	Belongs to the ArsC family
GO176_RS17390	COG1876	peptidase activity
GO176_RS17400	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GO176_RS17405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO176_RS17410	COG2716	regulation of RNA biosynthetic process
GO176_RS17415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO176_RS17435	COG4783	chaperone-mediated protein folding
GO176_RS17440	COG1393	Belongs to the ArsC family
GO176_RS17460	COG2233	PERMEase
GO176_RS17465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GO176_RS17470	COG0737	Belongs to the 5'-nucleotidase family
GO176_RS17480	COG2912	Transglutaminase-like superfamily
GO176_RS17485	COG3094	Invasion gene expression up-regulator, SirB
GO176_RS17490	COG2890	protein-(glutamine-N5) methyltransferase activity
GO176_RS17500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GO176_RS17505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GO176_RS17515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO176_RS17520	COG0193	aminoacyl-tRNA hydrolase activity
GO176_RS17625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO176_RS17635	COG3951	Flagellar rod assembly protein muramidase FlgJ
GO176_RS17635	COG1705	Flagellar rod assembly protein muramidase FlgJ
GO176_RS17640	COG1706	bacterial-type flagellum-dependent cell motility
GO176_RS17645	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO176_RS17650	COG4786	Flagellar basal body rod
GO176_RS17655	COG4787	bacterial-type flagellum-dependent cell motility
GO176_RS17660	COG1749	Flagellar hook protein flgE
GO176_RS17665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO176_RS17670	COG1558	bacterial-type flagellum-dependent cell motility
GO176_RS17675	COG1815	bacterial-type flagellum-dependent cell motility
GO176_RS17680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GO176_RS17685	COG0784	Response regulator, receiver
GO176_RS17685	COG0835	chemotaxis
GO176_RS17695	COG2747	anti-sigma28 factor FlgM
GO176_RS17735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO176_RS17740	COG2608	mercury ion transmembrane transporter activity
GO176_RS17740	COG2217	Heavy metal translocating P-type atpase
GO176_RS17775	COG2840	Smr protein MutS2
GO176_RS17780	COG1187	pseudouridine synthase activity
GO176_RS17785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO176_RS17790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO176_RS17795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO176_RS17800	COG0121	glutamine amidotransferase
GO176_RS17805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO176_RS17810	COG1960	acyl-CoA dehydrogenase activity
GO176_RS17820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO176_RS17830	COG2226	methyltransferase
GO176_RS17835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO176_RS17840	COG0741	lytic transglycosylase activity
GO176_RS17840	COG1388	LysM domain
GO176_RS17855	COG0347	Belongs to the P(II) protein family
GO176_RS17865	COG0037	tRNA processing
GO176_RS17870	COG0825	malonyl-CoA metabolic process
GO176_RS17880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO176_RS17895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO176_RS17900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO176_RS17905	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GO176_RS17915	COG0750	zinc metalloprotease
GO176_RS17920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO176_RS17925	COG0575	Belongs to the CDS family
GO176_RS17930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO176_RS17935	COG0233	cytoplasmic translational termination
GO176_RS17955	COG0024	Methionine aminopeptidase
GO176_RS17970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO176_RS17975	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GO176_RS17980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO176_RS18000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO176_RS18000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO176_RS18005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO176_RS18010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO176_RS18030	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GO176_RS18060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO176_RS18065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO176_RS18070	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO176_RS18075	COG0189	ligase activity
GO176_RS18075	COG4067	protein conserved in archaea
GO176_RS18080	COG0189	ligase activity
GO176_RS18090	COG0733	neurotransmitter:sodium symporter activity
GO176_RS18120	COG1477	protein flavinylation
GO176_RS18125	COG2871	sodium ion transport
GO176_RS18130	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO176_RS18135	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO176_RS18145	COG1805	sodium ion transport
GO176_RS18150	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO176_RS18230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO176_RS18235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GO176_RS18240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO176_RS18245	COG0590	tRNA wobble adenosine to inosine editing
GO176_RS18255	COG0542	response to heat
GO176_RS18265	COG0564	pseudouridine synthase activity
GO176_RS18270	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO176_RS18275	COG0741	lytic transglycosylase activity
GO176_RS18280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO176_RS18285	COG0077	Prephenate dehydratase
GO176_RS18285	COG1605	Chorismate mutase
GO176_RS18295	COG5001	Diguanylate cyclase
GO176_RS18300	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GO176_RS18315	COG0488	(ABC) transporter
GO176_RS18330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO176_RS18335	COG3275	phosphorelay sensor kinase activity
GO176_RS18340	COG3279	Response regulator of the LytR AlgR family
GO176_RS18350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GO176_RS18355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GO176_RS18370	COG1966	Carbon starvation protein
GO176_RS18375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO176_RS18380	COG1047	Peptidyl-prolyl cis-trans
GO176_RS18385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GO176_RS18390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO176_RS18395	COG0196	riboflavin kinase activity
GO176_RS18410	COG0640	Transcriptional regulator
GO176_RS18415	COG0583	DNA-binding transcription factor activity
GO176_RS18420	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO176_RS18425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GO176_RS18435	COG0730	response to heat
GO176_RS18450	COG3066	DNA modification
GO176_RS18460	COG0667	Aldo Keto reductase
GO176_RS18470	COG2204	response regulator
GO176_RS18475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GO176_RS18490	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GO176_RS18495	COG0513	Belongs to the DEAD box helicase family
GO176_RS18500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GO176_RS18520	COG3153	acetyltransferase
GO176_RS18545	COG0534	Mate efflux family protein
GO176_RS18565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GO176_RS18570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO176_RS18575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO176_RS18580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GO176_RS18585	COG0195	Participates in both transcription termination and antitermination
GO176_RS18590	COG0779	Required for maturation of 30S ribosomal subunits
GO176_RS18605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO176_RS18610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO176_RS18615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO176_RS18620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO176_RS18630	COG1534	Rna-binding protein
GO176_RS18635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO176_RS18640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GO176_RS18660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO176_RS18680	COG0316	Belongs to the HesB IscA family
GO176_RS18685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO176_RS18690	COG0628	permease
GO176_RS18695	COG2813	Specifically methylates the guanine in position
GO176_RS18700	COG0784	Response regulator, receiver
GO176_RS18700	COG2205	protein histidine kinase activity
GO176_RS18705	COG0747	negative chemotaxis
GO176_RS18715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO176_RS18720	COG0444	Belongs to the ABC transporter superfamily
GO176_RS18725	COG4608	Belongs to the ABC transporter superfamily
GO176_RS18750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO176_RS18755	COG1943	Transposase
GO176_RS18760	COG3842	ATPase activity
GO176_RS18770	COG1840	ABC-type Fe3 transport system, periplasmic component
GO176_RS18775	COG0004	ammonium transporteR
GO176_RS18780	COG0347	Belongs to the P(II) protein family
GO176_RS18785	COG3112	Uncharacterised protein family (UPF0231)
GO176_RS18790	COG1049	propionate catabolic process, 2-methylcitrate cycle
GO176_RS18795	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO176_RS18800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO176_RS18805	COG1643	Atp-dependent helicase
GO176_RS18810	COG1489	DNA binding
GO176_RS18815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO176_RS18830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO176_RS18835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO176_RS18840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO176_RS18845	COG0842	Transport permease protein
GO176_RS18850	COG1131	(ABC) transporter
GO176_RS18855	COG0288	reversible hydration of carbon dioxide
GO176_RS18870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO176_RS18875	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO176_RS18880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GO176_RS18885	COG2186	Transcriptional regulator
GO176_RS18890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO176_RS18895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO176_RS18900	COG4974	Belongs to the 'phage' integrase family
GO176_RS18905	COG0716	FMN binding
GO176_RS18925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO176_RS18940	COG0237	dephospho-CoA kinase activity
GO176_RS18945	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GO176_RS18950	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GO176_RS18960	COG0187	DNA topoisomerase II activity
GO176_RS18965	COG3150	esterase
GO176_RS18975	COG3151	Protein conserved in bacteria
GO176_RS18985	COG1538	Outer membrane efflux protein
GO176_RS18990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GO176_RS18990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GO176_RS18995	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO176_RS19005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO176_RS19010	COG3025	triphosphatase activity
GO176_RS19015	COG1392	Phosphate transport regulator
GO176_RS19020	COG0306	phosphate transporter
GO176_RS19025	COG4991	sh3 domain protein
GO176_RS19035	COG3267	Type II secretory pathway component ExeA
GO176_RS19035	COG3409	Peptidoglycan-binding domain 1 protein
GO176_RS19040	COG0617	tRNA 3'-terminal CCA addition
GO176_RS19045	COG0148	phosphopyruvate hydratase activity
GO176_RS19050	COG0504	CTP synthase activity
GO176_RS19065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO176_RS19080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GO176_RS19085	COG1381	Involved in DNA repair and RecF pathway recombination
GO176_RS19090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GO176_RS19100	COG0681	Belongs to the peptidase S26 family
GO176_RS19105	COG0481	GTPase activity
GO176_RS19110	COG3086	response to oxidative stress
GO176_RS19125	COG1595	DNA-templated transcription, initiation
GO176_RS19140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GO176_RS19160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO176_RS19165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO176_RS19175	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GO176_RS19185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO176_RS19190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GO176_RS19195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO176_RS19200	COG0440	acetolactate synthase activity
GO176_RS19205	COG0028	Belongs to the TPP enzyme family
GO176_RS19215	COG0583	DNA-binding transcription factor activity
GO176_RS19235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO176_RS19245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO176_RS19250	COG0066	3-isopropylmalate dehydratase activity
GO176_RS19295	COG3437	response regulator, receiver
GO176_RS19330	COG3118	belongs to the thioredoxin family
GO176_RS19340	COG0861	Integral membrane protein TerC family
GO176_RS19345	COG1028	Short-chain dehydrogenase reductase Sdr
GO176_RS19355	COG3217	Mosc domain protein beta barrel domain protein
GO176_RS19355	COG0633	Ferredoxin
GO176_RS19365	COG0583	DNA-binding transcription factor activity
GO176_RS19380	COG2814	Major facilitator Superfamily
GO176_RS19440	COG2916	Histone family protein nucleoid-structuring protein H-NS
GO176_RS19445	COG0745	RESPONSE REGULATOR receiver
GO176_RS19445	COG3706	GGDEF domain
GO176_RS19500	COG3706	GGDEF domain
GO176_RS19510	COG0795	lipopolysaccharide-transporting ATPase activity
GO176_RS19515	COG0795	lipopolysaccharide-transporting ATPase activity
GO176_RS19520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO176_RS19530	COG0525	valine-tRNA ligase activity
GO176_RS19535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO176_RS19540	COG0564	pseudouridine synthase activity
GO176_RS19550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO176_RS19560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO176_RS19565	COG0540	Belongs to the ATCase OTCase family
GO176_RS19570	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GO176_RS19575	COG0251	oxidation-reduction process
GO176_RS19580	COG0204	Acyl-transferase
GO176_RS19590	COG5007	Belongs to the BolA IbaG family
GO176_RS19595	COG3113	response to antibiotic
GO176_RS19600	COG2854	intermembrane phospholipid transfer
GO176_RS19605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO176_RS19610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GO176_RS19615	COG1127	ABC transporter
GO176_RS19625	COG0517	IMP dehydrogenase activity
GO176_RS19625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO176_RS19630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GO176_RS19640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GO176_RS19645	COG1137	ATPase activity
GO176_RS19655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO176_RS19660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO176_RS19670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO176_RS19675	COG2239	Acts as a magnesium transporter
GO176_RS19680	COG0312	modulator of DNA gyrase
GO176_RS19685	COG3028	Belongs to the UPF0307 family
GO176_RS19690	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GO176_RS19695	COG1178	ABC-type Fe3 transport system permease component
GO176_RS19700	COG4143	(ABC) transporter
GO176_RS19710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO176_RS19715	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GO176_RS19720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GO176_RS19730	COG2105	PFAM AIG2 family protein
GO176_RS19740	COG0729	surface antigen
GO176_RS19745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO176_RS19750	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GO176_RS19765	COG0577	efflux transmembrane transporter activity
GO176_RS19765	COG1136	(ABC) transporter
GO176_RS19785	COG0529	Catalyzes the synthesis of activated sulfate
GO176_RS19790	COG0471	metal ion transport
GO176_RS19790	COG3273	potassium ion transport
GO176_RS19795	COG2895	sulfate adenylyltransferase (ATP) activity
GO176_RS19800	COG0175	sulfate reduction
GO176_RS19805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO176_RS19805	COG1648	precorrin-2 dehydrogenase activity
GO176_RS19820	COG0513	Belongs to the DEAD box helicase family
GO176_RS19835	COG3061	Opacity-associated protein A
GO176_RS19850	COG0203	ribosomal protein L17
GO176_RS19855	COG0202	RNA polymerase activity
GO176_RS19860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO176_RS19865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO176_RS19870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GO176_RS19880	COG0201	protein transport
GO176_RS19890	COG1841	ribosomal large subunit assembly
GO176_RS19900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO176_RS19905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO176_RS19910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO176_RS19915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO176_RS19920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO176_RS19925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GO176_RS19930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO176_RS19935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GO176_RS19940	COG0255	Belongs to the universal ribosomal protein uL29 family
GO176_RS19955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GO176_RS19960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GO176_RS19970	COG0089	rRNA binding
GO176_RS19975	COG0088	Forms part of the polypeptide exit tunnel
GO176_RS19980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO176_RS19985	COG0051	transcription antitermination factor activity, RNA binding
GO176_RS19990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO176_RS20005	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GO176_RS20010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GO176_RS20020	COG1047	Peptidyl-prolyl cis-trans
GO176_RS20025	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GO176_RS20035	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO176_RS20040	COG0488	(ABC) transporter
GO176_RS20050	COG0429	hydrolase of the alpha beta-hydrolase fold
GO176_RS20065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO176_RS20075	COG1012	belongs to the aldehyde dehydrogenase family
GO176_RS20085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO176_RS20090	COG0512	Glutamine amidotransferase of anthranilate synthase
GO176_RS20100	COG0180	Tryptophanyl-tRNA synthetase
GO176_RS20110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO176_RS20125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO176_RS20160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GO176_RS20170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO176_RS20170	COG0678	peroxiredoxin activity
GO176_RS20180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO176_RS20180	COG0165	Argininosuccinate lyase
GO176_RS20190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO176_RS20195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO176_RS20200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO176_RS20205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GO176_RS20215	COG1045	serine acetyltransferase
GO176_RS20225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GO176_RS20230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO176_RS20240	COG1053	succinate dehydrogenase
GO176_RS20245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO176_RS20250	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO176_RS20255	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO176_RS20260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO176_RS20265	COG1509	lysine 2,3-aminomutase activity
GO176_RS20270	COG1285	pathogenesis
GO176_RS20280	COG1119	ATPase activity
GO176_RS20285	COG0459	protein refolding
GO176_RS20290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GO176_RS20315	COG0149	triose-phosphate isomerase activity
GO176_RS20320	COG0534	Mate efflux family protein
GO176_RS20325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO176_RS20330	COG1575	Belongs to the MenA family. Type 1 subfamily
GO176_RS20335	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO176_RS20350	COG1609	Transcriptional regulator
GO176_RS20355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO176_RS20365	COG0281	malic enzyme
GO176_RS20375	COG0626	cystathionine gamma-synthase activity
GO176_RS20380	COG0460	homoserine dehydrogenase
GO176_RS20380	COG0527	aspartate kinase activity
GO176_RS20385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GO176_RS20395	COG1494	fructose-1,6-bisphosphatase
GO176_RS20400	COG0205	6-phosphofructokinase activity
GO176_RS20415	COG0745	RESPONSE REGULATOR receiver
GO176_RS20425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO176_RS20430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO176_RS20445	COG1027	Aspartate ammonia-lyase
GO176_RS20450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO176_RS20455	COG1288	antiporter activity
GO176_RS20470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO176_RS20475	COG1943	Transposase
GO176_RS20480	COG0540	Belongs to the ATCase OTCase family
GO176_RS20485	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GO176_RS20510	COG3263	regulation of cellular component size
GO176_RS20520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO176_RS20525	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO176_RS20530	COG0194	GDP metabolic process
GO176_RS20540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO176_RS20545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO176_RS20550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO176_RS20555	COG2233	PERMEase
GO176_RS20560	COG2205	protein histidine kinase activity
GO176_RS20565	COG0745	RESPONSE REGULATOR receiver
GO176_RS20570	COG0800	Aldolase
GO176_RS20575	COG2610	gluconate transmembrane transporter activity
GO176_RS20580	COG3265	gluconokinase activity
GO176_RS20590	COG1609	Transcriptional regulator
GO176_RS20595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO176_RS20605	COG2183	response to ionizing radiation
GO176_RS20615	COG0596	Alpha beta hydrolase
GO176_RS20620	COG1040	competence protein
GO176_RS20625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO176_RS20625	COG0316	Belongs to the HesB IscA family
GO176_RS20630	COG0494	nUDIX hydrolase
GO176_RS20635	COG1218	3'(2'),5'-bisphosphate nucleotidase
GO176_RS20645	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GO176_RS20650	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GO176_RS20655	COG3156	type II secretion system protein K
GO176_RS20660	COG4795	General secretion pathway protein
GO176_RS20665	COG2165	general secretion pathway protein
GO176_RS20670	COG2165	general secretion pathway protein
GO176_RS20675	COG2165	general secretion pathway protein
GO176_RS20680	COG1459	type II secretion system
GO176_RS20685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO176_RS20695	COG3031	protein transport across the cell outer membrane
GO176_RS20700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GO176_RS20710	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO176_RS20715	COG2982	Protein involved in outer membrane biogenesis
GO176_RS20720	COG0456	acetyltransferase
GO176_RS20725	COG1490	D-aminoacyl-tRNA deacylase activity
GO176_RS20750	COG0174	glutamine synthetase
GO176_RS20760	COG3852	Histidine kinase
GO176_RS20765	COG2204	response regulator
GO176_RS20770	COG3300	MHYT domain
GO176_RS20770	COG5001	Diguanylate cyclase
GO176_RS20775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO176_RS20810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO176_RS20825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO176_RS20865	COG2003	Belongs to the UPF0758 family
GO176_RS20900	COG0210	DNA helicase
GO176_RS20925	COG0534	Mate efflux family protein
GO176_RS20935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO176_RS20940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO176_RS20945	COG2937	Belongs to the GPAT DAPAT family
GO176_RS20950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GO176_RS20955	COG3161	chorismate lyase activity
GO176_RS20960	COG1580	Controls the rotational direction of flagella during chemotaxis
GO176_RS20970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO176_RS20975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO176_RS20985	COG2884	Cell division ATP-binding protein ftsE
GO176_RS20990	COG0552	protein localization to endoplasmic reticulum
GO176_RS20995	COG0742	ribosomal rna small subunit methyltransferase
GO176_RS21005	COG2095	MarC family integral membrane protein
GO176_RS21035	COG0783	Belongs to the Dps family
GO176_RS21050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO176_RS21055	COG0640	Transcriptional regulator
GO176_RS21060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO176_RS21065	COG1280	lysine exporter protein (LysE YggA)
GO176_RS21070	COG2267	carboxylic ester hydrolase activity
GO176_RS21075	COG0561	phosphatase activity
GO176_RS21095	COG2199	diguanylate cyclase activity
GO176_RS21095	COG2200	EAL domain
GO176_RS21095	COG3287	FIST C domain
GO176_RS21100	COG1011	Hydrolase
GO176_RS21105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GO176_RS21135	COG3072	Adenylate cyclase
GO176_RS21150	COG2959	enzyme of heme biosynthesis
GO176_RS21155	COG3071	HemY protein
GO176_RS21185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GO176_RS21190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO176_RS21190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO176_RS21205	COG0084	hydrolase, TatD family'
GO176_RS21210	COG0805	protein transport
GO176_RS21215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO176_RS21230	COG3165	ubiquinone biosynthetic process from chorismate
GO176_RS21235	COG2226	methyltransferase
GO176_RS21265	COG2160	L-arabinose isomerase activity
GO176_RS21280	COG1879	ABC-type sugar transport system periplasmic component
GO176_RS21285	COG1129	ABC transporter
GO176_RS21290	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO176_RS21295	COG1879	ABC-type sugar transport system periplasmic component
GO176_RS21300	COG1129	ABC transporter
GO176_RS21305	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO176_RS21315	COG2081	HI0933 family
GO176_RS21325	COG1528	Iron-storage protein
GO176_RS21330	COG0589	response to stress
GO176_RS21335	COG0697	spore germination
GO176_RS21345	COG0742	ribosomal rna small subunit methyltransferase
GO176_RS21350	COG5001	Diguanylate cyclase
GO176_RS21350	COG5002	protein histidine kinase activity
GO176_RS21355	COG1522	sequence-specific DNA binding
GO176_RS21375	COG0006	proline dipeptidase activity
GO176_RS21375	COG0006	proline dipeptidase activity
GO176_RS21390	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GO176_RS21410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO176_RS21415	COG2022	thiamine diphosphate biosynthetic process
GO176_RS21425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO176_RS21435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GO176_RS21440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO176_RS21445	COG2132	Multicopper oxidase
GO176_RS21520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO176_RS21525	COG1739	Uncharacterized protein family UPF0029
GO176_RS21535	COG0183	Belongs to the thiolase family
GO176_RS21540	COG0583	DNA-binding transcription factor activity
GO176_RS21545	COG2814	Major facilitator Superfamily
GO176_RS21555	COG0765	amino acid transport
GO176_RS21565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO176_RS21575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO176_RS21585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO176_RS21590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO176_RS21600	COG0356	it plays a direct role in the translocation of protons across the membrane
GO176_RS21605	COG3312	ion transport
GO176_RS21610	COG1475	DNA binding
GO176_RS21615	COG1192	Involved in chromosome partitioning
GO176_RS21620	COG0357	Ribosomal RNA small subunit methyltransferase G
GO176_RS21625	COG0445	tRNA wobble uridine modification
GO176_RS21640	COG0706	membrane insertase activity
GO176_RS21645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO176_RS21655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GO176_RS21660	COG1126	abc transporter atp-binding protein
GO176_RS21680	COG0592	DNA-directed DNA polymerase activity
GO176_RS21690	COG0187	DNA topoisomerase II activity
GO176_RS21700	COG0071	Belongs to the small heat shock protein (HSP20) family
GO176_RS21705	COG3977	Valine--pyruvate aminotransferase
GO176_RS21710	COG0751	glycine-tRNA ligase activity
GO176_RS21715	COG0752	glycyl-tRNA synthetase alpha subunit
GO176_RS21720	COG2119	membrane
GO176_RS21740	COG2199	diguanylate cyclase activity
GO176_RS21745	COG2199	diguanylate cyclase activity
GO176_RS21745	COG2203	Gaf domain
GO176_RS21755	COG0604	alcohol dehydrogenase
GO176_RS21770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO176_RS21775	COG3978	acetolactate synthase activity
GO176_RS21785	COG0606	chelatase, subunit chli
GO176_RS21790	COG0204	Acyl-transferase
GO176_RS21795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO176_RS21800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO176_RS21810	COG3084	Protein conserved in bacteria
GO176_RS21820	COG4326	sporulation control protein
GO176_RS21825	COG1272	protein, Hemolysin III
GO176_RS21835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO176_RS21840	COG0569	domain protein
GO176_RS21845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO176_RS21845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO176_RS21855	COG0242	peptide deformylase activity
GO176_RS21870	COG2922	Belongs to the Smg family
GO176_RS21880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO176_RS21895	COG0408	coproporphyrinogen oxidase activity
GO176_RS21900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO176_RS21910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GO176_RS21955	COG0583	DNA-binding transcription factor activity
GO176_RS21965	COG2960	long-chain fatty acid transporting porin activity
GO176_RS21970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO176_RS21975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO176_RS21980	COG1309	transcriptional regulator
GO176_RS22020	COG4172	Belongs to the ABC transporter superfamily
GO176_RS22025	COG0747	negative chemotaxis
GO176_RS22035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO176_RS22070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO176_RS22075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO176_RS22090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO176_RS22095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GO176_RS22130	COG0210	DNA helicase
GO176_RS22135	COG0405	Gamma-glutamyltransferase
GO176_RS22140	COG1280	lysine exporter protein (LysE YggA)
GO176_RS22150	COG2962	Rard protein
GO176_RS22155	COG0514	ATP-dependent DNA helicase (RecQ)
GO176_RS22170	COG1132	(ABC) transporter
GO176_RS22175	COG4774	siderophore transport
GO176_RS22180	COG1120	ATPase activity
GO176_RS22185	COG4607	ABC-type enterochelin transport system periplasmic component
GO176_RS22200	COG1561	YicC-like family, N-terminal region
GO176_RS22205	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GO176_RS22210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO176_RS22215	COG1560	Kdo2-lipid A biosynthetic process
GO176_RS22220	COG1309	transcriptional regulator
GO176_RS22245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GO176_RS22255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO176_RS22275	COG0438	transferase activity, transferring glycosyl groups
GO176_RS22280	COG0438	transferase activity, transferring glycosyl groups
GO176_RS22285	COG0463	Glycosyl transferase, family 2
GO176_RS22290	COG0859	PFAM glycosyl transferase family 9
GO176_RS22310	COG0859	PFAM glycosyl transferase family 9
GO176_RS22315	COG0859	PFAM glycosyl transferase family 9
GO176_RS22340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO176_RS22345	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO176_RS22440	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GO176_RS22445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO176_RS22450	COG1051	belongs to the nudix hydrolase family
GO176_RS22475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO176_RS22485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GO176_RS22495	COG0741	lytic transglycosylase activity
GO176_RS22515	COG1573	uracil-dna glycosylase
GO176_RS22520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO176_RS22525	COG3068	Protein conserved in bacteria
GO176_RS22530	COG0668	transmembrane transport
GO176_RS22535	COG1253	flavin adenine dinucleotide binding
GO176_RS22540	COG0776	regulation of translation
GO176_RS22550	COG0151	Belongs to the GarS family
GO176_RS22555	COG0138	bifunctional purine biosynthesis protein purh
GO176_RS22560	COG0789	Transcriptional regulator
GO176_RS22565	COG1940	carbohydrate kinase activity
GO176_RS22580	COG2207	Transcriptional regulator
GO176_RS22595	COG0840	transmembrane signaling receptor activity
GO176_RS22600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GO176_RS22605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO176_RS22610	COG2264	protein methyltransferase activity
GO176_RS22615	COG0439	Biotin carboxylase
GO176_RS22620	COG0511	ligase activity, forming carbon-carbon bonds
GO176_RS22630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO176_RS22645	COG2814	Major facilitator Superfamily
GO176_RS22650	COG0784	Response regulator, receiver
GO176_RS22650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO176_RS22650	COG2198	Histidine kinase
GO176_RS22650	COG2205	protein histidine kinase activity
GO176_RS22655	COG0248	Ppx GppA phosphatase
GO176_RS22660	COG0513	Belongs to the DEAD box helicase family
GO176_RS22665	COG3118	belongs to the thioredoxin family
GO176_RS22670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GO176_RS22725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO176_RS22735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO176_RS22745	COG1072	(Pantothenic acid kinase))
GO176_RS22775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO176_RS22780	COG0250	Participates in transcription elongation, termination and antitermination
GO176_RS22790	COG0081	regulation of translation
GO176_RS22795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO176_RS22800	COG0222	ribosome binding
GO176_RS22805	COG0085	RNA polymerase activity
GO176_RS22810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO176_RS22815	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GO176_RS22840	COG4942	peptidase
GO176_RS22845	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO176_RS22865	COG0688	phosphatidylethanolamine metabolic process
GO176_RS22870	COG1162	GTPase activity
GO176_RS22925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GO176_RS22930	COG0802	atpase or kinase
GO176_RS22945	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO176_RS22955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO176_RS22960	COG0330	HflC and HflK could
GO176_RS22965	COG0330	HflC and HflK could
GO176_RS22970	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GO176_RS22975	COG2900	Belongs to the SlyX family
GO176_RS22985	COG0545	Peptidyl-prolyl cis-trans isomerase
GO176_RS22990	COG2964	Protein conserved in bacteria
GO176_RS23000	COG2923	Belongs to the DsrF TusC family
GO176_RS23005	COG2168	tRNA wobble position uridine thiolation
GO176_RS23015	COG0049	tRNA binding
GO176_RS23020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO176_RS23030	COG2906	2 iron, 2 sulfur cluster binding
GO176_RS23040	COG0360	Binds together with S18 to 16S ribosomal RNA
GO176_RS23045	COG2965	DNA replication, synthesis of RNA primer
GO176_RS23055	COG0359	binds to the 23S rRNA
GO176_RS23065	COG0305	Participates in initiation and elongation during chromosome replication
GO176_RS23070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO176_RS23075	COG0432	Pfam Uncharacterised protein family UPF0047
GO176_RS23080	COG0166	Belongs to the GPI family
GO176_RS23090	COG0735	belongs to the Fur family
GO176_RS23095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO176_RS23115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO176_RS23125	COG0175	sulfate reduction
GO176_RS23190	COG0646	methionine synthase
GO176_RS23190	COG1410	methionine synthase
GO176_RS23195	COG0527	aspartate kinase activity
GO176_RS23200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO176_RS23210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GO176_RS23225	COG0629	single-stranded DNA binding
GO176_RS23230	COG2200	EAL domain
GO176_RS23230	COG2199	diguanylate cyclase activity
GO176_RS23255	COG3267	Type II secretory pathway component ExeA
GO176_RS23255	COG3409	Peptidoglycan-binding domain 1 protein
GO176_RS23265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO176_RS23315	COG1077	Cell shape determining protein MreB Mrl
GO176_RS23320	COG1792	Involved in formation and maintenance of cell shape
GO176_RS23325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO176_RS23330	COG0424	maF-like protein
GO176_RS23335	COG1530	ribonuclease E activity