locus-tag	class	description
GPY38_RS00010	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY38_RS00015	COG3028	Belongs to the UPF0307 family
GPY38_RS00020	COG0312	modulator of DNA gyrase
GPY38_RS00025	COG2239	Acts as a magnesium transporter
GPY38_RS00030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS00040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS00045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY38_RS00055	COG1137	ATPase activity
GPY38_RS00060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY38_RS00070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GPY38_RS00075	COG0517	IMP dehydrogenase activity
GPY38_RS00075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY38_RS00085	COG1127	ABC transporter
GPY38_RS00090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY38_RS00095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY38_RS00100	COG2854	intermembrane phospholipid transfer
GPY38_RS00105	COG3113	response to antibiotic
GPY38_RS00110	COG5007	Belongs to the BolA IbaG family
GPY38_RS00120	COG0204	Acyl-transferase
GPY38_RS00125	COG0251	oxidation-reduction process
GPY38_RS00130	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY38_RS00135	COG0540	Belongs to the ATCase OTCase family
GPY38_RS00140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY38_RS00145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY38_RS00150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY38_RS00160	COG0564	pseudouridine synthase activity
GPY38_RS00165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY38_RS00170	COG0525	valine-tRNA ligase activity
GPY38_RS00180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY38_RS00185	COG0795	lipopolysaccharide-transporting ATPase activity
GPY38_RS00190	COG0795	lipopolysaccharide-transporting ATPase activity
GPY38_RS00200	COG3706	GGDEF domain
GPY38_RS00265	COG3437	response regulator, receiver
GPY38_RS00310	COG0066	3-isopropylmalate dehydratase activity
GPY38_RS00320	COG0473	3-isopropylmalate dehydrogenase activity
GPY38_RS00325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY38_RS00345	COG0583	DNA-binding transcription factor activity
GPY38_RS00350	COG1022	Amp-dependent synthetase and ligase
GPY38_RS00355	COG0028	Belongs to the TPP enzyme family
GPY38_RS00360	COG0440	acetolactate synthase activity
GPY38_RS00365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY38_RS00370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY38_RS00375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY38_RS00385	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY38_RS00395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY38_RS00400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY38_RS00415	COG0354	folic acid binding
GPY38_RS00420	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY38_RS00430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY38_RS00435	COG1595	DNA-templated transcription, initiation
GPY38_RS00450	COG3086	response to oxidative stress
GPY38_RS00455	COG0481	GTPase activity
GPY38_RS00460	COG0681	Belongs to the peptidase S26 family
GPY38_RS00470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY38_RS00475	COG1381	Involved in DNA repair and RecF pathway recombination
GPY38_RS00480	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY38_RS00495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY38_RS00500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY38_RS00505	COG3956	TIGRFAM MazG family protein
GPY38_RS00510	COG0504	CTP synthase activity
GPY38_RS00515	COG0148	phosphopyruvate hydratase activity
GPY38_RS00520	COG0617	tRNA 3'-terminal CCA addition
GPY38_RS00525	COG3267	Type II secretory pathway component ExeA
GPY38_RS00525	COG3409	Peptidoglycan-binding domain 1 protein
GPY38_RS00535	COG4991	sh3 domain protein
GPY38_RS00540	COG0306	phosphate transporter
GPY38_RS00545	COG1392	Phosphate transport regulator
GPY38_RS00550	COG3025	triphosphatase activity
GPY38_RS00555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY38_RS00565	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY38_RS00570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY38_RS00570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY38_RS00575	COG1538	Outer membrane efflux protein
GPY38_RS00580	COG0494	nUDIX hydrolase
GPY38_RS00585	COG3151	Protein conserved in bacteria
GPY38_RS00595	COG3150	esterase
GPY38_RS00600	COG0187	DNA topoisomerase II activity
GPY38_RS00610	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY38_RS00615	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY38_RS00620	COG0237	dephospho-CoA kinase activity
GPY38_RS00630	COG1459	type II secretion system
GPY38_RS00635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY38_RS00655	COG0716	FMN binding
GPY38_RS00660	COG4974	Belongs to the 'phage' integrase family
GPY38_RS00665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY38_RS00670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY38_RS00675	COG2186	Transcriptional regulator
GPY38_RS00680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY38_RS00685	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY38_RS00690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY38_RS00705	COG0288	reversible hydration of carbon dioxide
GPY38_RS00710	COG1131	(ABC) transporter
GPY38_RS00715	COG0842	Transport permease protein
GPY38_RS00720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY38_RS00725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY38_RS00730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY38_RS00740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY38_RS00745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY38_RS00750	COG1489	DNA binding
GPY38_RS00755	COG1643	Atp-dependent helicase
GPY38_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY38_RS00775	COG3112	Uncharacterised protein family (UPF0231)
GPY38_RS00780	COG0347	Belongs to the P(II) protein family
GPY38_RS00785	COG0004	ammonium transporteR
GPY38_RS00790	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY38_RS00800	COG3842	ATPase activity
GPY38_RS00805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY38_RS00820	COG2971	BadF BadG BcrA BcrD
GPY38_RS00830	COG4608	Belongs to the ABC transporter superfamily
GPY38_RS00835	COG0444	Belongs to the ABC transporter superfamily
GPY38_RS00840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY38_RS00850	COG0747	negative chemotaxis
GPY38_RS00855	COG0784	Response regulator, receiver
GPY38_RS00855	COG2205	protein histidine kinase activity
GPY38_RS00860	COG2813	Specifically methylates the guanine in position
GPY38_RS00865	COG0628	permease
GPY38_RS00870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY38_RS00875	COG0316	Belongs to the HesB IscA family
GPY38_RS00890	COG0739	heme binding
GPY38_RS00895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY38_RS00905	COG2239	Acts as a magnesium transporter
GPY38_RS00910	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY38_RS00915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY38_RS00920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY38_RS00925	COG1534	Rna-binding protein
GPY38_RS00930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY38_RS00935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY38_RS00940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY38_RS00950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY38_RS00965	COG0779	Required for maturation of 30S ribosomal subunits
GPY38_RS00970	COG0195	Participates in both transcription termination and antitermination
GPY38_RS00975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY38_RS00980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY38_RS00985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY38_RS00990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY38_RS01010	COG0534	Mate efflux family protein
GPY38_RS01035	COG3153	acetyltransferase
GPY38_RS01055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY38_RS01060	COG0513	Belongs to the DEAD box helicase family
GPY38_RS01065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY38_RS01080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY38_RS01085	COG2204	response regulator
GPY38_RS01095	COG0667	Aldo Keto reductase
GPY38_RS01105	COG3066	DNA modification
GPY38_RS01120	COG0730	response to heat
GPY38_RS01130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY38_RS01135	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY38_RS01140	COG0583	DNA-binding transcription factor activity
GPY38_RS01145	COG0640	Transcriptional regulator
GPY38_RS01155	COG0728	peptidoglycan biosynthetic process
GPY38_RS01160	COG0196	riboflavin kinase activity
GPY38_RS01165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY38_RS01170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY38_RS01175	COG1047	Peptidyl-prolyl cis-trans
GPY38_RS01180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY38_RS01185	COG1966	Carbon starvation protein
GPY38_RS01200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY38_RS01205	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY38_RS01215	COG3279	Response regulator of the LytR AlgR family
GPY38_RS01225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY38_RS01230	COG1605	Chorismate mutase
GPY38_RS01230	COG0287	Prephenate dehydrogenase
GPY38_RS01240	COG0488	(ABC) transporter
GPY38_RS01255	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY38_RS01260	COG5001	Diguanylate cyclase
GPY38_RS01265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY38_RS01270	COG1605	Chorismate mutase
GPY38_RS01270	COG0077	Prephenate dehydratase
GPY38_RS01275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY38_RS01280	COG0741	lytic transglycosylase activity
GPY38_RS01285	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY38_RS01290	COG0564	pseudouridine synthase activity
GPY38_RS01300	COG0542	response to heat
GPY38_RS01310	COG0590	tRNA wobble adenosine to inosine editing
GPY38_RS01315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY38_RS01325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY38_RS01385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY38_RS01400	COG0271	Belongs to the BolA IbaG family
GPY38_RS01405	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY38_RS01410	COG1805	sodium ion transport
GPY38_RS01420	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY38_RS01425	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY38_RS01430	COG2871	sodium ion transport
GPY38_RS01435	COG1477	protein flavinylation
GPY38_RS01450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY38_RS01460	COG2203	Gaf domain
GPY38_RS01460	COG3706	GGDEF domain
GPY38_RS01460	COG4251	negative regulation of phosphorylation
GPY38_RS01460	COG5001	Diguanylate cyclase
GPY38_RS01465	COG0733	neurotransmitter:sodium symporter activity
GPY38_RS01475	COG0189	ligase activity
GPY38_RS01480	COG4067	protein conserved in archaea
GPY38_RS01480	COG0189	ligase activity
GPY38_RS01485	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY38_RS01490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY38_RS01495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY38_RS01505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY38_RS01515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY38_RS01520	COG2252	PERMEase
GPY38_RS01525	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY38_RS01545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY38_RS01555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY38_RS01555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY38_RS01575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY38_RS01580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY38_RS01585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY38_RS01595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY38_RS01600	COG0024	Methionine aminopeptidase
GPY38_RS01620	COG0233	cytoplasmic translational termination
GPY38_RS01625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY38_RS01630	COG0575	Belongs to the CDS family
GPY38_RS01635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY38_RS01640	COG0750	zinc metalloprotease
GPY38_RS01650	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY38_RS01655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY38_RS01660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY38_RS01685	COG0825	malonyl-CoA metabolic process
GPY38_RS01700	COG0347	Belongs to the P(II) protein family
GPY38_RS01715	COG0741	lytic transglycosylase activity
GPY38_RS01715	COG1388	LysM domain
GPY38_RS01720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY38_RS01725	COG2226	methyltransferase
GPY38_RS01735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY38_RS01745	COG1960	acyl-CoA dehydrogenase activity
GPY38_RS01750	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY38_RS01755	COG0121	glutamine amidotransferase
GPY38_RS01760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY38_RS01765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY38_RS01770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY38_RS01775	COG1187	pseudouridine synthase activity
GPY38_RS01780	COG2840	Smr protein MutS2
GPY38_RS01810	COG2608	mercury ion transmembrane transporter activity
GPY38_RS01810	COG2217	Heavy metal translocating P-type atpase
GPY38_RS01815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY38_RS01885	COG2747	anti-sigma28 factor FlgM
GPY38_RS01895	COG0835	chemotaxis
GPY38_RS01895	COG0784	Response regulator, receiver
GPY38_RS01900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY38_RS01905	COG1815	bacterial-type flagellum-dependent cell motility
GPY38_RS01910	COG1558	bacterial-type flagellum-dependent cell motility
GPY38_RS01915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY38_RS01920	COG1749	Flagellar hook protein flgE
GPY38_RS01925	COG4787	bacterial-type flagellum-dependent cell motility
GPY38_RS01930	COG4786	Flagellar basal body rod
GPY38_RS01935	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY38_RS01940	COG1706	bacterial-type flagellum-dependent cell motility
GPY38_RS01945	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY38_RS01945	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY38_RS01955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY38_RS01960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY38_RS02060	COG0193	aminoacyl-tRNA hydrolase activity
GPY38_RS02065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY38_RS02080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY38_RS02090	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY38_RS02095	COG3094	Invasion gene expression up-regulator, SirB
GPY38_RS02100	COG2912	Transglutaminase-like superfamily
GPY38_RS02110	COG0737	Belongs to the 5'-nucleotidase family
GPY38_RS02115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY38_RS02120	COG2233	PERMEase
GPY38_RS02140	COG1393	Belongs to the ArsC family
GPY38_RS02145	COG4783	chaperone-mediated protein folding
GPY38_RS02165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY38_RS02170	COG2716	regulation of RNA biosynthetic process
GPY38_RS02175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY38_RS02180	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY38_RS02190	COG1876	peptidase activity
GPY38_RS02195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY38_RS02200	COG1393	Belongs to the ArsC family
GPY38_RS02210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY38_RS02215	COG1085	galactose-1-phosphate uridylyltransferase
GPY38_RS02220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY38_RS02235	COG0516	GMP reductase activity
GPY38_RS02235	COG0517	IMP dehydrogenase activity
GPY38_RS02255	COG2837	iron assimilation
GPY38_RS02270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY38_RS02275	COG1334	flagellar protein FlaG
GPY38_RS02280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY38_RS02290	COG1516	flagellar protein fliS
GPY38_RS02295	COG2204	response regulator
GPY38_RS02300	COG4191	Histidine kinase
GPY38_RS02305	COG2204	response regulator
GPY38_RS02310	COG1677	Flagellar hook-basal body complex protein FliE
GPY38_RS02320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY38_RS02370	COG1987	bacterial-type flagellum assembly
GPY38_RS02390	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY38_RS02395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY38_RS02400	COG2860	membrane
GPY38_RS02405	COG3101	peptidyl-lysine hydroxylation
GPY38_RS02420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY38_RS02420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY38_RS02425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY38_RS02430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY38_RS02435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY38_RS02440	COG0735	belongs to the Fur family
GPY38_RS02450	COG0583	DNA-binding transcription factor activity
GPY38_RS02455	COG1380	Effector of murein hydrolase LrgA
GPY38_RS02460	COG1346	cytolysis
GPY38_RS02475	COG0596	Alpha beta hydrolase
GPY38_RS02480	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY38_RS02485	COG0033	Phosphoglucomutase
GPY38_RS02495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY38_RS02505	COG2009	succinate dehydrogenase
GPY38_RS02510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY38_RS02515	COG1053	succinate dehydrogenase
GPY38_RS02525	COG0567	Dehydrogenase, E1 component
GPY38_RS02530	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY38_RS02545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY38_RS02550	COG1121	(ABC) transporter
GPY38_RS02555	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY38_RS02560	COG2207	Transcriptional regulator
GPY38_RS02565	COG1918	ferrous iron import across plasma membrane
GPY38_RS02590	COG3102	Protein conserved in bacteria
GPY38_RS02600	COG2062	phosphohistidine phosphatase, SixA
GPY38_RS02615	COG0455	bacterial-type flagellum organization
GPY38_RS02630	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY38_RS02635	COG0643	Histidine kinase
GPY38_RS02635	COG2198	Histidine kinase
GPY38_RS02645	COG1192	Involved in chromosome partitioning
GPY38_RS02655	COG0835	chemotaxis
GPY38_RS02665	COG4133	protoheme IX ABC transporter activity
GPY38_RS02670	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY38_RS02675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY38_RS02680	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY38_RS02685	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY38_RS02690	COG1138	Cytochrome C-type biogenesis protein
GPY38_RS02695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY38_RS02710	COG2853	Lipoprotein
GPY38_RS02730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY38_RS02735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY38_RS02765	COG0667	Aldo Keto reductase
GPY38_RS02780	COG0583	DNA-binding transcription factor activity
GPY38_RS02785	COG2159	amidohydrolase
GPY38_RS02790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY38_RS02830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY38_RS02845	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY38_RS02875	COG2814	Major facilitator Superfamily
GPY38_RS02890	COG3083	sulfuric ester hydrolase activity
GPY38_RS02900	COG3081	Nucleoid-associated protein
GPY38_RS02910	COG1757	Na H antiporter
GPY38_RS02915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY38_RS02920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY38_RS02925	COG2095	MarC family integral membrane protein
GPY38_RS02930	COG1454	alcohol dehydrogenase
GPY38_RS02930	COG1012	belongs to the aldehyde dehydrogenase family
GPY38_RS02940	COG0659	secondary active sulfate transmembrane transporter activity
GPY38_RS02950	COG1530	ribonuclease E activity
GPY38_RS02955	COG0564	pseudouridine synthase activity
GPY38_RS02960	COG0424	maF-like protein
GPY38_RS02965	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY38_RS02975	COG0416	fatty acid biosynthetic process
GPY38_RS02980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY38_RS03000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY38_RS03005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY38_RS03010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY38_RS03015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY38_RS03020	COG0470	DNA polymerase III
GPY38_RS03025	COG0084	hydrolase, TatD family'
GPY38_RS03030	COG2190	(PTS) system
GPY38_RS03030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY38_RS03030	COG1263	PTS System
GPY38_RS03055	COG0733	neurotransmitter:sodium symporter activity
GPY38_RS03070	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY38_RS03075	COG0469	pyruvate kinase activity
GPY38_RS03080	COG1940	carbohydrate kinase activity
GPY38_RS03085	COG0835	chemotaxis
GPY38_RS03085	COG0784	Response regulator, receiver
GPY38_RS03090	COG0587	DNA-directed DNA polymerase activity
GPY38_RS03105	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS03110	COG0616	signal peptide processing
GPY38_RS03130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY38_RS03135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY38_RS03140	COG0436	Aminotransferase
GPY38_RS03150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY38_RS03160	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY38_RS03165	COG1441	menaquinone biosynthetic process
GPY38_RS03180	COG2855	membrane
GPY38_RS03185	COG0477	Major facilitator Superfamily
GPY38_RS03210	COG0741	lytic transglycosylase activity
GPY38_RS03210	COG1388	LysM domain
GPY38_RS03230	COG1815	bacterial-type flagellum-dependent cell motility
GPY38_RS03235	COG1558	bacterial-type flagellum-dependent cell motility
GPY38_RS03240	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY38_RS03245	COG1749	Flagellar hook protein flgE
GPY38_RS03255	COG4786	Flagellar basal body rod
GPY38_RS03260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY38_RS03265	COG1706	bacterial-type flagellum-dependent cell motility
GPY38_RS03275	COG4786	Flagellar basal body rod
GPY38_RS03275	COG1256	bacterial-type flagellum assembly
GPY38_RS03305	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GPY38_RS03345	COG3015	lipoprotein NlpE involved in copper resistance
GPY38_RS03355	COG1360	Flagellar Motor Protein
GPY38_RS03360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY38_RS03365	COG1191	sigma factor activity
GPY38_RS03370	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY38_RS03390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY38_RS03395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY38_RS03410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY38_RS03420	COG1987	bacterial-type flagellum assembly
GPY38_RS03440	COG3047	cAMP biosynthetic process
GPY38_RS03440	COG2885	chlorophyll binding
GPY38_RS03445	COG2204	response regulator
GPY38_RS03485	COG1522	sequence-specific DNA binding
GPY38_RS03490	COG1946	Acyl-CoA thioesterase
GPY38_RS03495	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY38_RS03510	COG5001	Diguanylate cyclase
GPY38_RS03510	COG5002	protein histidine kinase activity
GPY38_RS03520	COG0583	DNA-binding transcription factor activity
GPY38_RS03525	COG0679	Auxin Efflux Carrier
GPY38_RS03530	COG3711	transcriptional antiterminator
GPY38_RS03535	COG1263	PTS System
GPY38_RS03535	COG2190	(PTS) system
GPY38_RS03535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY38_RS03540	COG2723	6-phospho-beta-galactosidase activity
GPY38_RS03565	COG1881	PFAM PEBP family protein
GPY38_RS03570	COG2207	Transcriptional regulator
GPY38_RS03605	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY38_RS03610	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY38_RS03630	COG0513	Belongs to the DEAD box helicase family
GPY38_RS03635	COG1368	sulfuric ester hydrolase activity
GPY38_RS03640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY38_RS03645	COG2194	sulfuric ester hydrolase activity
GPY38_RS03650	COG4566	intracellular signal transduction
GPY38_RS03685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY38_RS03690	COG1271	oxidase subunit
GPY38_RS03695	COG1294	oxidase, subunit
GPY38_RS03720	COG2223	nitrite transmembrane transporter activity
GPY38_RS03725	COG3279	Response regulator of the LytR AlgR family
GPY38_RS03730	COG3275	phosphorelay sensor kinase activity
GPY38_RS03745	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY38_RS03760	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY38_RS03765	COG1169	isochorismate synthase
GPY38_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS03775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY38_RS03780	COG2226	methyltransferase
GPY38_RS03780	COG3433	isochorismatase activity
GPY38_RS03780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY38_RS03800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY38_RS03810	COG1629	transport
GPY38_RS03810	COG4774	siderophore transport
GPY38_RS03820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY38_RS03825	COG1120	ATPase activity
GPY38_RS03835	COG1609	Transcriptional regulator
GPY38_RS03840	COG2723	6-phospho-beta-galactosidase activity
GPY38_RS03845	COG1741	Belongs to the pirin family
GPY38_RS03855	COG4172	Belongs to the ABC transporter superfamily
GPY38_RS03860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY38_RS03865	COG0601	transmembrane transport
GPY38_RS03870	COG0747	negative chemotaxis
GPY38_RS03880	COG1538	Outer membrane efflux protein
GPY38_RS03885	COG1566	PFAM secretion protein HlyD family protein
GPY38_RS03890	COG2814	Major facilitator Superfamily
GPY38_RS03895	COG3708	Transcriptional regulator
GPY38_RS03895	COG2207	Transcriptional regulator
GPY38_RS03905	COG0745	RESPONSE REGULATOR receiver
GPY38_RS03915	COG1263	PTS System
GPY38_RS03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY38_RS03925	COG1621	beta-fructofuranosidase activity
GPY38_RS03940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY38_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS03965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY38_RS03990	COG2986	histidine ammonia-lyase
GPY38_RS03995	COG1216	Glycosyl transferase, family 2
GPY38_RS04015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY38_RS04020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY38_RS04025	COG0318	PFAM AMP-dependent synthetase and ligase
GPY38_RS04025	COG0204	Acyl-transferase
GPY38_RS04055	COG0601	transmembrane transport
GPY38_RS04060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY38_RS04065	COG0444	Belongs to the ABC transporter superfamily
GPY38_RS04080	COG0435	Glutathione S-transferase
GPY38_RS04085	COG3174	membrane
GPY38_RS04090	COG0280	phosphate acetyltransferase
GPY38_RS04090	COG0857	belongs to the CobB CobQ family
GPY38_RS04095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY38_RS04100	COG3092	negative regulation of chromosome organization
GPY38_RS04110	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY38_RS04120	COG3706	GGDEF domain
GPY38_RS04130	COG2165	general secretion pathway protein
GPY38_RS04135	COG0653	protein targeting
GPY38_RS04140	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY38_RS04145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY38_RS04150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY38_RS04160	COG0243	molybdopterin cofactor binding
GPY38_RS04180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY38_RS04180	COG1116	anion transmembrane transporter activity
GPY38_RS04185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY38_RS04195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY38_RS04195	COG2146	nitrite reductase [NAD(P)H] activity
GPY38_RS04210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY38_RS04220	COG2226	methyltransferase
GPY38_RS04225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY38_RS04230	COG0501	Belongs to the peptidase M48B family
GPY38_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS04255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY38_RS04275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY38_RS04280	COG2915	High frequency lysogenization protein hflD homolog
GPY38_RS04285	COG0482	sulfurtransferase activity
GPY38_RS04290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY38_RS04295	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY38_RS04300	COG1757	Na H antiporter
GPY38_RS04305	COG3604	Transcriptional regulator
GPY38_RS04310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY38_RS04315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY38_RS04320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY38_RS04325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY38_RS04325	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY38_RS04330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY38_RS04335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY38_RS04345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY38_RS04345	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY38_RS04350	COG1187	pseudouridine synthase activity
GPY38_RS04360	COG1695	Transcriptional regulator
GPY38_RS04365	COG2223	nitrite transmembrane transporter activity
GPY38_RS04375	COG1278	Cold shock
GPY38_RS04380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY38_RS04385	COG0542	response to heat
GPY38_RS04390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY38_RS04395	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY38_RS04400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY38_RS04410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY38_RS04420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY38_RS04425	COG3706	GGDEF domain
GPY38_RS04425	COG0745	RESPONSE REGULATOR receiver
GPY38_RS04430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY38_RS04435	COG0297	glycogen (starch) synthase activity
GPY38_RS04455	COG3070	regulator of competence-specific genes
GPY38_RS04460	COG1609	Transcriptional regulator
GPY38_RS04465	COG3381	protein complex oligomerization
GPY38_RS04470	COG0745	RESPONSE REGULATOR receiver
GPY38_RS04480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY38_RS04485	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY38_RS04490	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY38_RS04495	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY38_RS04510	COG4067	protein conserved in archaea
GPY38_RS04510	COG0189	ligase activity
GPY38_RS04515	COG0500	methyltransferase
GPY38_RS04520	COG4106	trans-aconitate 2-methyltransferase activity
GPY38_RS04525	COG1801	Protein of unknown function DUF72
GPY38_RS04535	COG1435	thymidine kinase activity
GPY38_RS04540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY38_RS04545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY38_RS04550	COG0583	DNA-binding transcription factor activity
GPY38_RS04565	COG2116	formate transmembrane transporter activity
GPY38_RS04570	COG0390	transport system, permease component
GPY38_RS04575	COG4459	periplasmic nitrate reductase
GPY38_RS04580	COG3005	denitrification pathway
GPY38_RS04585	COG0243	molybdopterin cofactor binding
GPY38_RS04605	COG1227	inorganic diphosphatase activity
GPY38_RS04620	COG4172	Belongs to the ABC transporter superfamily
GPY38_RS04630	COG4171	peptide transport system, permease
GPY38_RS04635	COG4168	peptide transport system, permease
GPY38_RS04645	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY38_RS04650	COG1842	Phage shock protein A
GPY38_RS04665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY38_RS04680	COG2818	Glycosylase
GPY38_RS04685	COG0626	cystathionine gamma-synthase activity
GPY38_RS04695	COG0733	neurotransmitter:sodium symporter activity
GPY38_RS04705	COG0564	pseudouridine synthase activity
GPY38_RS04715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY38_RS04720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY38_RS04725	COG4136	ATPase activity
GPY38_RS04730	COG4135	transport system, permease component
GPY38_RS04735	COG4134	Bacterial extracellular solute-binding protein
GPY38_RS04745	COG3313	Fe-S protein
GPY38_RS04755	COG0842	Transport permease protein
GPY38_RS04760	COG1131	(ABC) transporter
GPY38_RS04770	COG0814	amino acid
GPY38_RS04780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY38_RS04785	COG1278	Cold shock
GPY38_RS04810	COG1737	Transcriptional regulator
GPY38_RS04825	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY38_RS04830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY38_RS04840	COG3153	acetyltransferase
GPY38_RS04855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY38_RS04860	COG0642	Histidine kinase
GPY38_RS04865	COG0745	RESPONSE REGULATOR receiver
GPY38_RS04875	COG1061	Type III restriction enzyme res subunit
GPY38_RS04885	COG2814	Major facilitator Superfamily
GPY38_RS04895	COG0702	epimerase
GPY38_RS04900	COG0534	Mate efflux family protein
GPY38_RS04905	COG4181	ATPase activity
GPY38_RS04920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY38_RS04965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY38_RS04980	COG3265	gluconokinase activity
GPY38_RS04985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY38_RS05015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY38_RS05020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY38_RS05035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY38_RS05060	COG2989	Protein conserved in bacteria
GPY38_RS05065	COG3108	Peptidase M15
GPY38_RS05070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY38_RS05085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY38_RS05110	COG1846	Transcriptional regulator
GPY38_RS05115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY38_RS05120	COG0840	transmembrane signaling receptor activity
GPY38_RS05125	COG2176	DNA-directed DNA polymerase activity
GPY38_RS05140	COG1448	Aminotransferase
GPY38_RS05155	COG0017	Asparaginyl-tRNA synthetase
GPY38_RS05165	COG0720	synthase
GPY38_RS05185	COG1136	(ABC) transporter
GPY38_RS05185	COG0577	efflux transmembrane transporter activity
GPY38_RS05190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY38_RS05195	COG1760	l-serine dehydratase
GPY38_RS05200	COG0814	amino acid
GPY38_RS05205	COG0494	nUDIX hydrolase
GPY38_RS05220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY38_RS05235	COG3106	COG3106 Predicted ATPase
GPY38_RS05245	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY38_RS05250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY38_RS05275	COG0471	metal ion transport
GPY38_RS05280	COG4191	Histidine kinase
GPY38_RS05280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY38_RS05295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY38_RS05300	COG0778	Nitroreductase
GPY38_RS05305	COG2991	Protein conserved in bacteria
GPY38_RS05315	COG3250	beta-galactosidase activity
GPY38_RS05325	COG1129	ABC transporter
GPY38_RS05370	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY38_RS05380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPY38_RS05400	COG1566	PFAM secretion protein HlyD family protein
GPY38_RS05405	COG2814	Major facilitator Superfamily
GPY38_RS05425	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY38_RS05430	COG2200	EAL domain
GPY38_RS05440	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY38_RS05450	COG0625	glutathione transferase activity
GPY38_RS05470	COG2731	YhcH YjgK YiaL family protein
GPY38_RS05480	COG1349	DNA-binding transcription factor activity
GPY38_RS05485	COG3842	ATPase activity
GPY38_RS05490	COG0395	ABC-type sugar transport system, permease component
GPY38_RS05495	COG1175	transmembrane transport
GPY38_RS05510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY38_RS05515	COG3040	lipid binding
GPY38_RS05525	COG0811	peptide transport
GPY38_RS05530	COG0811	peptide transport
GPY38_RS05535	COG0848	biopolymer transport protein
GPY38_RS05555	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY38_RS05560	COG1793	dna ligase
GPY38_RS05575	COG0307	riboflavin synthase, alpha
GPY38_RS05595	COG0791	NLP P60 protein
GPY38_RS05625	COG0303	'Molybdopterin
GPY38_RS05630	COG0746	molybdenum cofactor guanylyltransferase activity
GPY38_RS05635	COG3842	ATPase activity
GPY38_RS05640	COG4662	Binding-protein-dependent transport system inner membrane component
GPY38_RS05650	COG2204	response regulator
GPY38_RS05655	COG3852	Histidine kinase
GPY38_RS05670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY38_RS05690	COG3381	protein complex oligomerization
GPY38_RS05705	COG0437	4 iron, 4 sulfur cluster binding
GPY38_RS05720	COG0004	ammonium transporteR
GPY38_RS05725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY38_RS05730	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY38_RS05735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY38_RS05740	COG1177	transmembrane transport
GPY38_RS05745	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY38_RS05750	COG3842	ATPase activity
GPY38_RS05775	COG0589	response to stress
GPY38_RS05780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY38_RS05795	COG2217	Heavy metal translocating P-type atpase
GPY38_RS05805	COG2010	Cytochrome c
GPY38_RS05820	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY38_RS05855	COG3120	sequence-specific DNA binding
GPY38_RS05860	COG1067	ATP-dependent peptidase activity
GPY38_RS05865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY38_RS05880	COG0488	(ABC) transporter
GPY38_RS05890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY38_RS05890	COG0116	Belongs to the methyltransferase superfamily
GPY38_RS05905	COG0167	dihydroorotate dehydrogenase activity
GPY38_RS05910	COG2902	Dehydrogenase
GPY38_RS05920	COG0308	aminopeptidase N
GPY38_RS05940	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY38_RS05945	COG1956	GAF domain-containing protein
GPY38_RS05950	COG1132	(ABC) transporter
GPY38_RS05955	COG2995	paraquat-inducible protein a
GPY38_RS05960	COG3008	intermembrane lipid transfer
GPY38_RS05965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY38_RS05965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY38_RS05970	COG2996	Protein conserved in bacteria
GPY38_RS05990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY38_RS06000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY38_RS06015	COG1115	amino acid carrier protein
GPY38_RS06040	COG3501	Rhs element vgr protein
GPY38_RS06050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY38_RS06065	COG1414	Transcriptional regulator
GPY38_RS06070	COG0583	DNA-binding transcription factor activity
GPY38_RS06075	COG4638	Rieske (2fe-2S)
GPY38_RS06080	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GPY38_RS06095	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY38_RS06105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY38_RS06125	COG3384	dioxygenase
GPY38_RS06140	COG1643	Atp-dependent helicase
GPY38_RS06145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY38_RS06175	COG3706	GGDEF domain
GPY38_RS06190	COG0443	Heat shock 70 kDa protein
GPY38_RS06195	COG3706	GGDEF domain
GPY38_RS06220	COG2999	glutathione oxidoreductase activity
GPY38_RS06230	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GPY38_RS06235	COG0243	molybdopterin cofactor binding
GPY38_RS06240	COG3005	denitrification pathway
GPY38_RS06245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY38_RS06250	COG0602	queuosine metabolic process
GPY38_RS06255	COG0561	phosphatase activity
GPY38_RS06265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY38_RS06270	COG4597	amino acid ABC transporter
GPY38_RS06275	COG0765	amino acid transport
GPY38_RS06280	COG1126	abc transporter atp-binding protein
GPY38_RS06285	COG0670	Belongs to the BI1 family
GPY38_RS06290	COG2920	part of a sulfur-relay system
GPY38_RS06295	COG1254	Belongs to the acylphosphatase family
GPY38_RS06300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY38_RS06305	COG3391	amine dehydrogenase activity
GPY38_RS06315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY38_RS06335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY38_RS06340	COG5002	protein histidine kinase activity
GPY38_RS06345	COG0745	RESPONSE REGULATOR receiver
GPY38_RS06365	COG0668	transmembrane transport
GPY38_RS06395	COG0745	RESPONSE REGULATOR receiver
GPY38_RS06395	COG3706	GGDEF domain
GPY38_RS06405	COG0709	Synthesizes selenophosphate from selenide and ATP
GPY38_RS06410	COG2897	thiosulfate sulfurtransferase activity
GPY38_RS06415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY38_RS06420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GPY38_RS06425	COG0375	protein maturation
GPY38_RS06430	COG0309	Hydrogenase expression formation protein (HypE)
GPY38_RS06440	COG0298	carbon dioxide binding
GPY38_RS06445	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GPY38_RS06455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY38_RS06460	COG3604	Transcriptional regulator
GPY38_RS06470	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY38_RS06475	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GPY38_RS06485	COG3260	NADH ubiquinone oxidoreductase 20
GPY38_RS06490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPY38_RS06495	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GPY38_RS06495	COG3261	NADH dehydrogenase
GPY38_RS06500	COG0650	Formate hydrogenlyase subunit 4
GPY38_RS06505	COG0651	ATP synthesis coupled electron transport
GPY38_RS06510	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY38_RS06520	COG1921	L-seryl-tRNASec selenium transferase activity
GPY38_RS06530	COG0835	chemotaxis
GPY38_RS06530	COG0784	Response regulator, receiver
GPY38_RS06540	COG4565	transcriptional regulatory protein
GPY38_RS06545	COG3290	protein histidine kinase activity
GPY38_RS06560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY38_RS06580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY38_RS06585	COG3063	Type IV pilus biogenesis stability protein PilW
GPY38_RS06600	COG1451	nucleotide metabolic process
GPY38_RS06610	COG0583	DNA-binding transcription factor activity
GPY38_RS06635	COG0110	maltose O-acetyltransferase activity
GPY38_RS06650	COG1874	Beta-galactosidase
GPY38_RS06660	COG3833	ABC-type maltose transport systems, permease component
GPY38_RS06665	COG1175	transmembrane transport
GPY38_RS06670	COG2182	Extracellular solute-binding protein
GPY38_RS06680	COG1609	Transcriptional regulator
GPY38_RS06725	COG4964	Belongs to the GSP D family
GPY38_RS06795	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY38_RS06800	COG4139	cobalamin transport
GPY38_RS06805	COG2988	succinylglutamate desuccinylase activity
GPY38_RS06820	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY38_RS06825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY38_RS06830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GPY38_RS06870	COG2925	Exonuclease
GPY38_RS06880	COG1346	cytolysis
GPY38_RS06885	COG0295	cytidine deaminase activity
GPY38_RS06890	COG5001	Diguanylate cyclase
GPY38_RS06910	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY38_RS06920	COG0500	methyltransferase
GPY38_RS06930	COG0776	regulation of translation
GPY38_RS06935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY38_RS06935	COG0072	phenylalanine-tRNA ligase activity
GPY38_RS06940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY38_RS06955	COG0745	RESPONSE REGULATOR receiver
GPY38_RS06955	COG3706	GGDEF domain
GPY38_RS06960	COG2133	pyrroloquinoline quinone binding
GPY38_RS06995	COG2197	response regulator
GPY38_RS07000	COG0417	DNA replication proofreading
GPY38_RS07010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY38_RS07030	COG1228	amidohydrolase
GPY38_RS07035	COG0010	Belongs to the arginase family
GPY38_RS07045	COG2986	histidine ammonia-lyase
GPY38_RS07065	COG0277	FAD linked oxidase domain protein
GPY38_RS07065	COG0247	lactate metabolic process
GPY38_RS07110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY38_RS07120	COG2957	Belongs to the agmatine deiminase family
GPY38_RS07130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY38_RS07135	COG1012	belongs to the aldehyde dehydrogenase family
GPY38_RS07140	COG1917	Cupin 2, conserved barrel domain protein
GPY38_RS07140	COG1396	sequence-specific DNA binding
GPY38_RS07145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY38_RS07150	COG0174	glutamine synthetase
GPY38_RS07155	COG1757	Na H antiporter
GPY38_RS07170	COG0583	DNA-binding transcription factor activity
GPY38_RS07185	COG1643	Atp-dependent helicase
GPY38_RS07190	COG0281	malic enzyme
GPY38_RS07200	COG0583	DNA-binding transcription factor activity
GPY38_RS07220	COG2949	membrane
GPY38_RS07230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY38_RS07250	COG0492	ferredoxin-NADP+ reductase activity
GPY38_RS07255	COG4988	ABC transporter
GPY38_RS07260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY38_RS07275	COG1187	pseudouridine synthase activity
GPY38_RS07280	COG0009	L-threonylcarbamoyladenylate synthase
GPY38_RS07290	COG0800	Aldolase
GPY38_RS07295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY38_RS07300	COG4145	pantothenate transmembrane transporter activity
GPY38_RS07310	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GPY38_RS07325	COG0613	PHP domain protein
GPY38_RS07335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY38_RS07340	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY38_RS07345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY38_RS07350	COG0134	indole-3-glycerol-phosphate synthase activity
GPY38_RS07350	COG0135	phosphoribosylanthranilate isomerase activity
GPY38_RS07355	COG0133	tryptophan synthase activity
GPY38_RS07365	COG1301	dicarboxylic acid transport
GPY38_RS07375	COG1607	acyl-coa hydrolase
GPY38_RS07380	COG2350	Protein conserved in bacteria
GPY38_RS07395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY38_RS07405	COG1360	Flagellar Motor Protein
GPY38_RS07410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY38_RS07415	COG1191	sigma factor activity
GPY38_RS07440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY38_RS07445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY38_RS07450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY38_RS07455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY38_RS07485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY38_RS07495	COG1677	Flagellar hook-basal body complex protein FliE
GPY38_RS07520	COG1706	bacterial-type flagellum-dependent cell motility
GPY38_RS07525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY38_RS07530	COG4786	Flagellar basal body rod
GPY38_RS07540	COG1749	Flagellar hook protein flgE
GPY38_RS07545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY38_RS07550	COG1558	bacterial-type flagellum-dependent cell motility
GPY38_RS07555	COG1815	bacterial-type flagellum-dependent cell motility
GPY38_RS07575	COG1987	bacterial-type flagellum assembly
GPY38_RS07600	COG0583	DNA-binding transcription factor activity
GPY38_RS07615	COG0612	Peptidase, M16
GPY38_RS07630	COG2200	EAL domain
GPY38_RS07630	COG2771	luxR family
GPY38_RS07635	COG0840	transmembrane signaling receptor activity
GPY38_RS07655	COG0346	lactoylglutathione lyase activity
GPY38_RS07665	COG0488	(ABC) transporter
GPY38_RS07670	COG1032	radical SAM domain protein
GPY38_RS07675	COG2211	Major facilitator Superfamily
GPY38_RS07680	COG3940	Belongs to the glycosyl hydrolase 43 family
GPY38_RS07690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY38_RS07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY38_RS07700	COG4191	Histidine kinase
GPY38_RS07715	COG3070	regulator of competence-specific genes
GPY38_RS07725	COG2431	L-lysine efflux transmembrane transporter activity
GPY38_RS07735	COG0076	glutamate decarboxylase activity
GPY38_RS07740	COG1737	Transcriptional regulator
GPY38_RS07750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY38_RS07760	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY38_RS07765	COG1960	acyl-CoA dehydrogenase activity
GPY38_RS07785	COG1012	belongs to the aldehyde dehydrogenase family
GPY38_RS07795	COG0700	Nucleoside recognition
GPY38_RS07800	COG3366	ferrous iron transmembrane transporter activity
GPY38_RS07810	COG0191	fructose-bisphosphate aldolase activity
GPY38_RS07820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS07825	COG3716	PTS system mannose fructose sorbose family IID component
GPY38_RS07835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY38_RS07840	COG2222	sugar isomerase
GPY38_RS07850	COG1349	DNA-binding transcription factor activity
GPY38_RS07855	COG1349	DNA-binding transcription factor activity
GPY38_RS07870	COG0784	Response regulator, receiver
GPY38_RS07870	COG5002	protein histidine kinase activity
GPY38_RS07885	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY38_RS07890	COG2885	chlorophyll binding
GPY38_RS07910	COG0811	peptide transport
GPY38_RS07915	COG0824	Thioesterase
GPY38_RS07925	COG4890	Cyd operon protein YbgT
GPY38_RS07930	COG1294	oxidase, subunit
GPY38_RS07935	COG1271	oxidase subunit
GPY38_RS07940	COG2255	four-way junction helicase activity
GPY38_RS07950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY38_RS07955	COG0215	cysteine-tRNA ligase activity
GPY38_RS07960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY38_RS07965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY38_RS07970	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY38_RS07975	COG3012	SEC-C Motif Domain Protein
GPY38_RS07985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY38_RS07990	COG1199	ATP-dependent helicase activity
GPY38_RS07995	COG3923	Primosomal replication protein n
GPY38_RS08010	COG0708	Exodeoxyribonuclease III
GPY38_RS08015	COG4160	amino acid transport
GPY38_RS08020	COG4215	(ABC) transporter
GPY38_RS08040	COG1882	Formate acetyltransferase
GPY38_RS08055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY38_RS08070	COG3713	MltA-interacting MipA family protein
GPY38_RS08085	COG2719	SpoVR family
GPY38_RS08090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY38_RS08100	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY38_RS08105	COG1132	(ABC) transporter
GPY38_RS08110	COG2333	competence protein COMEC
GPY38_RS08110	COG0658	competence protein
GPY38_RS08120	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY38_RS08125	COG1136	(ABC) transporter
GPY38_RS08130	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY38_RS08155	COG1252	NADH dehydrogenase
GPY38_RS08185	COG0537	adenosine 5'-monophosphoramidase activity
GPY38_RS08200	COG2186	Transcriptional regulator
GPY38_RS08205	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY38_RS08210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY38_RS08215	COG1674	ftsk spoiiie
GPY38_RS08220	COG1522	sequence-specific DNA binding
GPY38_RS08225	COG0686	Belongs to the AlaDH PNT family
GPY38_RS08255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY38_RS08260	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY38_RS08270	COG0539	negative regulation of cytoplasmic translation
GPY38_RS08275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY38_RS08280	COG1555	photosystem II stabilization
GPY38_RS08285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY38_RS08290	COG0776	regulation of translation
GPY38_RS08295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY38_RS08310	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY38_RS08315	COG4191	Histidine kinase
GPY38_RS08320	COG2204	response regulator
GPY38_RS08330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY38_RS08335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY38_RS08350	COG2205	protein histidine kinase activity
GPY38_RS08355	COG0745	RESPONSE REGULATOR receiver
GPY38_RS08360	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY38_RS08365	COG1760	l-serine dehydratase
GPY38_RS08375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY38_RS08375	COG3153	acetyltransferase
GPY38_RS08385	COG5001	Diguanylate cyclase
GPY38_RS08385	COG3300	MHYT domain
GPY38_RS08395	COG4589	Belongs to the CDS family
GPY38_RS08435	COG2207	Transcriptional regulator
GPY38_RS08445	COG2211	Major facilitator Superfamily
GPY38_RS08450	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GPY38_RS08465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY38_RS08470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY38_RS08480	COG2951	lytic endotransglycosylase activity
GPY38_RS08485	COG3100	YcgL domain-containing protein
GPY38_RS08490	COG0850	regulation of cytokinetic process
GPY38_RS08495	COG2894	cell division
GPY38_RS08500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY38_RS08510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY38_RS08520	COG2267	carboxylic ester hydrolase activity
GPY38_RS08535	COG1214	PFAM Peptidase M22, glycoprotease
GPY38_RS08550	COG0788	formyltetrahydrofolate deformylase activity
GPY38_RS08565	COG0252	asparaginase activity
GPY38_RS08570	COG3139	Protein of unknown function (DUF1315)
GPY38_RS08580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY38_RS08585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY38_RS08590	COG0676	glucose-6-phosphate 1-epimerase activity
GPY38_RS08595	COG2226	methyltransferase
GPY38_RS08620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY38_RS08625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY38_RS08630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY38_RS08640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY38_RS08645	COG2832	Protein of unknown function (DUF454)
GPY38_RS08660	COG0583	DNA-binding transcription factor activity
GPY38_RS08665	COG0778	Nitroreductase
GPY38_RS08670	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY38_RS08670	COG1024	Enoyl-CoA hydratase
GPY38_RS08675	COG0183	Belongs to the thiolase family
GPY38_RS08690	COG2067	long-chain fatty acid transport protein
GPY38_RS08695	COG2067	long-chain fatty acid transport protein
GPY38_RS08700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY38_RS08715	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY38_RS08720	COG2982	Protein involved in outer membrane biogenesis
GPY38_RS08725	COG0572	uridine kinase
GPY38_RS08735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY38_RS08735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY38_RS08745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY38_RS08755	COG0516	GMP reductase activity
GPY38_RS08755	COG0517	IMP dehydrogenase activity
GPY38_RS08760	COG3706	GGDEF domain
GPY38_RS08765	COG0314	molybdopterin synthase activity
GPY38_RS08770	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY38_RS08775	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY38_RS08780	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY38_RS08785	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY38_RS08790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY38_RS08795	COG2198	Histidine kinase
GPY38_RS08800	COG2204	response regulator
GPY38_RS08805	COG0556	nucleotide-excision repair
GPY38_RS08815	COG0582	viral genome integration into host DNA
GPY38_RS08830	COG2203	Gaf domain
GPY38_RS08830	COG5001	Diguanylate cyclase
GPY38_RS08830	COG4251	negative regulation of phosphorylation
GPY38_RS08830	COG3706	GGDEF domain
GPY38_RS08855	COG3706	GGDEF domain
GPY38_RS08865	COG2003	Belongs to the UPF0758 family
GPY38_RS08900	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY38_RS08920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPY38_RS08940	COG0328	RNA-DNA hybrid ribonuclease activity
GPY38_RS08980	COG1882	Formate acetyltransferase
GPY38_RS08985	COG4657	Part of a membrane complex involved in electron transport
GPY38_RS08990	COG2878	Part of a membrane complex involved in electron transport
GPY38_RS08995	COG4656	Part of a membrane complex involved in electron transport
GPY38_RS09000	COG4658	electron transport chain
GPY38_RS09005	COG4659	FMN binding
GPY38_RS09010	COG4660	Part of a membrane complex involved in electron transport
GPY38_RS09015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY38_RS09020	COG0346	lactoylglutathione lyase activity
GPY38_RS09035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY38_RS09040	COG2056	Na+-H+ antiporter family
GPY38_RS09045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY38_RS09050	COG1286	toxin biosynthetic process
GPY38_RS09055	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY38_RS09060	COG0285	dihydrofolate synthase activity
GPY38_RS09070	COG0101	tRNA pseudouridine synthase activity
GPY38_RS09080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY38_RS09085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY38_RS09085	COG2190	(PTS) system
GPY38_RS09085	COG1263	PTS System
GPY38_RS09090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY38_RS09095	COG1846	Transcriptional regulator
GPY38_RS09095	COG1940	carbohydrate kinase activity
GPY38_RS09100	COG4651	solute:proton antiporter activity
GPY38_RS09100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY38_RS09105	COG0367	asparagine synthase
GPY38_RS09130	COG0326	Molecular chaperone. Has ATPase activity
GPY38_RS09135	COG3710	Transcriptional regulator
GPY38_RS09150	COG0622	Phosphoesterase
GPY38_RS09180	COG0300	oxidoreductase activity
GPY38_RS09190	COG3118	belongs to the thioredoxin family
GPY38_RS09205	COG0789	Transcriptional regulator
GPY38_RS09225	COG3115	cell septum assembly
GPY38_RS09230	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY38_RS09235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY38_RS09240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS09250	COG2190	(PTS) system
GPY38_RS09255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY38_RS09260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY38_RS09265	COG1702	phosphate starvation-inducible protein PhoH
GPY38_RS09270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY38_RS09275	COG4535	Mg2 and Co2 transporter CorC
GPY38_RS09280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY38_RS09285	COG2888	peptidyl-tyrosine sulfation
GPY38_RS09290	COG0495	leucyl-tRNA aminoacylation
GPY38_RS09295	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY38_RS09300	COG1466	dna polymerase III delta subunit
GPY38_RS09305	COG0799	negative regulation of ribosome biogenesis
GPY38_RS09310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY38_RS09315	COG0768	penicillin binding
GPY38_RS09320	COG0772	Belongs to the SEDS family
GPY38_RS09325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY38_RS09330	COG1686	Belongs to the peptidase S11 family
GPY38_RS09335	COG2921	Belongs to the UPF0250 family
GPY38_RS09340	COG0321	lipoyl(octanoyl) transferase activity
GPY38_RS09345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY38_RS09365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY38_RS09370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY38_RS09400	COG2197	response regulator
GPY38_RS09410	COG2271	Major facilitator Superfamily
GPY38_RS09415	COG0366	Alpha amylase catalytic
GPY38_RS09420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY38_RS09420	COG1263	PTS System
GPY38_RS09435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY38_RS09440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY38_RS09445	COG2011	ABC-type metal ion transport system permease component
GPY38_RS09450	COG1464	Belongs to the NlpA lipoprotein family
GPY38_RS09455	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY38_RS09465	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY38_RS09465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY38_RS09475	COG3706	GGDEF domain
GPY38_RS09475	COG0745	RESPONSE REGULATOR receiver
GPY38_RS09480	COG1611	Belongs to the LOG family
GPY38_RS09485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY38_RS09495	COG2363	Small membrane protein
GPY38_RS09505	COG0583	DNA-binding transcription factor activity
GPY38_RS09510	COG0301	tRNA thio-modification
GPY38_RS09510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY38_RS09520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY38_RS09530	COG0142	geranyltranstransferase activity
GPY38_RS09535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY38_RS09540	COG0564	pseudouridine synthase activity
GPY38_RS09545	COG3098	single-species biofilm formation
GPY38_RS09570	COG1671	Belongs to the UPF0178 family
GPY38_RS09575	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY38_RS09580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY38_RS09585	COG0254	rRNA binding
GPY38_RS09590	COG1720	tRNA m6t6A37 methyltransferase activity
GPY38_RS09595	COG0442	prolyl-tRNA aminoacylation
GPY38_RS09620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY38_RS09620	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY38_RS09625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY38_RS09630	COG0590	tRNA wobble adenosine to inosine editing
GPY38_RS09635	COG0583	DNA-binding transcription factor activity
GPY38_RS09645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GPY38_RS09650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY38_RS09680	COG0484	heat shock protein binding
GPY38_RS09685	COG0443	Heat shock 70 kDa protein
GPY38_RS09695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY38_RS09700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY38_RS09705	COG0497	DNA recombination
GPY38_RS09710	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY38_RS09715	COG2914	Belongs to the UPF0125 (RnfH) family
GPY38_RS09720	COG2867	negative regulation of translational initiation
GPY38_RS09725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY38_RS09735	COG0582	viral genome integration into host DNA
GPY38_RS09765	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY38_RS09845	COG1279	arginine transmembrane transporter activity
GPY38_RS09910	COG0328	RNA-DNA hybrid ribonuclease activity
GPY38_RS09965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY38_RS09980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY38_RS09990	COG1115	amino acid carrier protein
GPY38_RS10010	COG3121	Chaperone
GPY38_RS10015	COG3188	usher protein
GPY38_RS10025	COG3710	Transcriptional regulator
GPY38_RS10030	COG1584	GPR1 FUN34 yaaH family protein
GPY38_RS10050	COG3833	ABC-type maltose transport systems, permease component
GPY38_RS10055	COG1175	transmembrane transport
GPY38_RS10060	COG2182	Extracellular solute-binding protein
GPY38_RS10070	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY38_RS10080	COG3842	ATPase activity
GPY38_RS10090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY38_RS10090	COG0519	Catalyzes the synthesis of GMP from XMP
GPY38_RS10095	COG0517	IMP dehydrogenase activity
GPY38_RS10095	COG0516	GMP reductase activity
GPY38_RS10115	COG1160	GTP binding
GPY38_RS10120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY38_RS10125	COG2976	Protein conserved in bacteria
GPY38_RS10130	COG0124	histidyl-tRNA synthetase
GPY38_RS10135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY38_RS10155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY38_RS10160	COG2975	iron-sulfur cluster assembly
GPY38_RS10165	COG0633	Ferredoxin
GPY38_RS10170	COG0443	Heat shock 70 kDa protein
GPY38_RS10185	COG0822	iron-sulfur transferase activity
GPY38_RS10190	COG1104	cysteine desulfurase activity
GPY38_RS10195	COG1959	2 iron, 2 sulfur cluster binding
GPY38_RS10205	COG0483	inositol monophosphate 1-phosphatase activity
GPY38_RS10210	COG1335	isochorismatase
GPY38_RS10215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY38_RS10220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY38_RS10225	COG1862	Preprotein translocase
GPY38_RS10230	COG0343	queuine tRNA-ribosyltransferase activity
GPY38_RS10235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY38_RS10240	COG0517	IMP dehydrogenase activity
GPY38_RS10255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY38_RS10260	COG0583	DNA-binding transcription factor activity
GPY38_RS10265	COG0450	alkyl hydroperoxide reductase
GPY38_RS10270	COG3142	Participates in the control of copper homeostasis
GPY38_RS10280	COG0704	Plays a role in the regulation of phosphate uptake
GPY38_RS10285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY38_RS10290	COG0581	inorganic phosphate transmembrane transporter activity
GPY38_RS10295	COG0573	inorganic phosphate transmembrane transporter activity
GPY38_RS10300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY38_RS10305	COG0248	Ppx GppA phosphatase
GPY38_RS10315	COG5002	protein histidine kinase activity
GPY38_RS10320	COG0745	RESPONSE REGULATOR receiver
GPY38_RS10325	COG2974	May be involved in recombination
GPY38_RS10335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY38_RS10340	COG0477	Major facilitator Superfamily
GPY38_RS10350	COG1595	DNA-templated transcription, initiation
GPY38_RS10360	COG3248	Nucleoside-binding outer membrane protein
GPY38_RS10365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY38_RS10370	COG0693	protein deglycase activity
GPY38_RS10375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY38_RS10380	COG2166	iron-sulfur cluster assembly
GPY38_RS10385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY38_RS10390	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY38_RS10400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY38_RS10400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY38_RS10410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY38_RS10415	COG1074	ATP-dependent DNA helicase activity
GPY38_RS10420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY38_RS10430	COG0583	DNA-binding transcription factor activity
GPY38_RS10435	COG3141	response to X-ray
GPY38_RS10440	COG2171	N-acyltransferase activity
GPY38_RS10445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY38_RS10475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY38_RS10480	COG2017	converts alpha-aldose to the beta-anomer
GPY38_RS10485	COG2059	Chromate
GPY38_RS10575	COG0583	DNA-binding transcription factor activity
GPY38_RS10585	COG0583	DNA-binding transcription factor activity
GPY38_RS10590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY38_RS10595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY38_RS10605	COG0560	Phosphoserine phosphatase
GPY38_RS10615	COG0813	purine-nucleoside phosphorylase activity
GPY38_RS10620	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY38_RS10625	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY38_RS10630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY38_RS10640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY38_RS10645	COG0084	hydrolase, TatD family'
GPY38_RS10655	COG1115	amino acid carrier protein
GPY38_RS10670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY38_RS10685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY38_RS10690	COG0083	homoserine kinase activity
GPY38_RS10715	COG0745	RESPONSE REGULATOR receiver
GPY38_RS10725	COG0784	Response regulator, receiver
GPY38_RS10725	COG2198	Histidine kinase
GPY38_RS10725	COG5002	protein histidine kinase activity
GPY38_RS10730	COG2203	Gaf domain
GPY38_RS10730	COG5001	Diguanylate cyclase
GPY38_RS10730	COG4251	negative regulation of phosphorylation
GPY38_RS10730	COG3706	GGDEF domain
GPY38_RS10735	COG1242	4 iron, 4 sulfur cluster binding
GPY38_RS10740	COG0069	glutamate synthase activity
GPY38_RS10740	COG0067	glutamate synthase
GPY38_RS10740	COG0070	glutamate synthase
GPY38_RS10750	COG0070	glutamate synthase
GPY38_RS10750	COG0069	glutamate synthase activity
GPY38_RS10750	COG0067	glutamate synthase
GPY38_RS10755	COG0493	'glutamate synthase
GPY38_RS10765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY38_RS10775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY38_RS10780	COG2860	membrane
GPY38_RS10800	COG0583	DNA-binding transcription factor activity
GPY38_RS10805	COG0730	response to heat
GPY38_RS10810	COG3479	Phenolic acid decarboxylase
GPY38_RS10820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY38_RS10825	COG0505	Belongs to the CarA family
GPY38_RS10835	COG0494	nUDIX hydrolase
GPY38_RS10840	COG0653	protein targeting
GPY38_RS10850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY38_RS10855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY38_RS10860	COG0849	cell division
GPY38_RS10865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY38_RS10875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY38_RS10880	COG0772	Belongs to the SEDS family
GPY38_RS10885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY38_RS10890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY38_RS10895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY38_RS10900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY38_RS10905	COG0768	penicillin binding
GPY38_RS10910	COG3116	cell division
GPY38_RS10915	COG0275	rRNA processing
GPY38_RS10925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY38_RS10930	COG3107	peptidoglycan biosynthetic process
GPY38_RS10935	COG0792	nuclease activity
GPY38_RS10940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY38_RS10945	COG2823	Periplasmic or secreted lipoprotein
GPY38_RS10950	COG2969	positive regulation of protein catabolic process
GPY38_RS10955	COG0625	glutathione transferase activity
GPY38_RS10960	COG2857	Cytochrome c1
GPY38_RS10965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY38_RS10970	COG0723	plastoquinol--plastocyanin reductase activity
GPY38_RS10975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY38_RS10980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY38_RS10990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY38_RS10995	COG3105	Protein conserved in bacteria
GPY38_RS11000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY38_RS11005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY38_RS11010	COG0335	large ribosomal subunit rRNA binding
GPY38_RS11020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY38_RS11030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY38_RS11035	COG4137	Cytochrome C assembly protein
GPY38_RS11040	COG4536	flavin adenine dinucleotide binding
GPY38_RS11045	COG1854	S-ribosylhomocysteine lyase activity
GPY38_RS11055	COG2918	glutathione biosynthetic process
GPY38_RS11060	COG0612	Peptidase, M16
GPY38_RS11070	COG1063	alcohol dehydrogenase
GPY38_RS11075	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY38_RS11080	COG0511	ligase activity, forming carbon-carbon bonds
GPY38_RS11080	COG5016	pyruvate
GPY38_RS11085	COG3630	sodium ion export across plasma membrane
GPY38_RS11135	COG0527	aspartate kinase activity
GPY38_RS11140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY38_RS11145	COG2137	regulation of response to DNA damage stimulus
GPY38_RS11150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY38_RS11155	COG1546	Belongs to the CinA family
GPY38_RS11160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY38_RS11165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY38_RS11175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY38_RS11180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY38_RS11185	COG0585	pseudouridine synthase activity
GPY38_RS11195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY38_RS11200	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY38_RS11205	COG1968	undecaprenyl-diphosphatase activity
GPY38_RS11210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY38_RS11215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY38_RS11220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY38_RS11230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY38_RS11235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY38_RS11240	COG1610	YqeY-like protein
GPY38_RS11245	COG0358	DNA primase activity
GPY38_RS11250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY38_RS11350	COG2131	deaminase
GPY38_RS11450	COG2378	regulation of single-species biofilm formation
GPY38_RS11470	COG2239	Acts as a magnesium transporter
GPY38_RS11485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY38_RS11490	COG1349	DNA-binding transcription factor activity
GPY38_RS11495	COG0469	pyruvate kinase activity
GPY38_RS11500	COG3706	GGDEF domain
GPY38_RS11515	COG1279	arginine transmembrane transporter activity
GPY38_RS11525	COG0668	transmembrane transport
GPY38_RS11530	COG0191	fructose-bisphosphate aldolase activity
GPY38_RS11535	COG0126	phosphoglycerate kinase activity
GPY38_RS11540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY38_RS11545	COG4771	TonB-dependent receptor
GPY38_RS11555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY38_RS11575	COG2356	endonuclease I
GPY38_RS11580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY38_RS11585	COG0189	ligase activity
GPY38_RS11590	COG1678	Uncharacterized ACR, COG1678
GPY38_RS11595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY38_RS11610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY38_RS11615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY38_RS11620	COG0762	integral membrane protein
GPY38_RS11625	COG1872	DUF167
GPY38_RS11640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY38_RS11650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY38_RS11655	COG1194	a g-specific adenine glycosylase
GPY38_RS11680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY38_RS11685	COG0741	lytic transglycosylase activity
GPY38_RS11735	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY38_RS11740	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY38_RS11745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY38_RS11760	COG2967	ApaG domain
GPY38_RS11765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY38_RS11775	COG3610	response to peptide
GPY38_RS11780	COG2966	Psort location CytoplasmicMembrane, score
GPY38_RS11785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY38_RS11790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY38_RS11795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY38_RS11800	COG0142	geranyltranstransferase activity
GPY38_RS11805	COG0531	amino acid
GPY38_RS11810	COG0039	L-malate dehydrogenase activity
GPY38_RS11830	COG0589	response to stress
GPY38_RS11850	COG0312	modulator of DNA gyrase
GPY38_RS11855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY38_RS11860	COG3164	Protein of unknown function
GPY38_RS11865	COG1530	ribonuclease E activity
GPY38_RS11870	COG0424	maF-like protein
GPY38_RS11875	COG0424	maF-like protein
GPY38_RS11880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY38_RS11885	COG1792	Involved in formation and maintenance of cell shape
GPY38_RS11890	COG1077	Cell shape determining protein MreB Mrl
GPY38_RS11940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY38_RS11950	COG3409	Peptidoglycan-binding domain 1 protein
GPY38_RS11950	COG3267	Type II secretory pathway component ExeA
GPY38_RS11975	COG2199	diguanylate cyclase activity
GPY38_RS11975	COG2200	EAL domain
GPY38_RS11980	COG0629	single-stranded DNA binding
GPY38_RS11995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY38_RS12005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY38_RS12010	COG0527	aspartate kinase activity
GPY38_RS12015	COG1410	methionine synthase
GPY38_RS12015	COG0646	methionine synthase
GPY38_RS12050	COG0175	sulfate reduction
GPY38_RS12060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY38_RS12080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY38_RS12085	COG0735	belongs to the Fur family
GPY38_RS12095	COG0166	Belongs to the GPI family
GPY38_RS12100	COG0432	Pfam Uncharacterised protein family UPF0047
GPY38_RS12105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY38_RS12110	COG0305	Participates in initiation and elongation during chromosome replication
GPY38_RS12120	COG0359	binds to the 23S rRNA
GPY38_RS12130	COG2965	DNA replication, synthesis of RNA primer
GPY38_RS12135	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY38_RS12145	COG2906	2 iron, 2 sulfur cluster binding
GPY38_RS12155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY38_RS12160	COG0049	tRNA binding
GPY38_RS12170	COG2168	tRNA wobble position uridine thiolation
GPY38_RS12175	COG2923	Belongs to the DsrF TusC family
GPY38_RS12185	COG2964	Protein conserved in bacteria
GPY38_RS12190	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY38_RS12200	COG2900	Belongs to the SlyX family
GPY38_RS12205	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY38_RS12210	COG0330	HflC and HflK could
GPY38_RS12215	COG0330	HflC and HflK could
GPY38_RS12220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY38_RS12230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY38_RS12235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY38_RS12245	COG0802	atpase or kinase
GPY38_RS12250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY38_RS12305	COG1162	GTPase activity
GPY38_RS12310	COG0688	phosphatidylethanolamine metabolic process
GPY38_RS12320	COG0840	transmembrane signaling receptor activity
GPY38_RS12330	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY38_RS12360	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY38_RS12365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY38_RS12370	COG0085	RNA polymerase activity
GPY38_RS12375	COG0222	ribosome binding
GPY38_RS12380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY38_RS12385	COG0081	regulation of translation
GPY38_RS12395	COG0250	Participates in transcription elongation, termination and antitermination
GPY38_RS12400	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY38_RS12430	COG1072	(Pantothenic acid kinase))
GPY38_RS12440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY38_RS12450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY38_RS12495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY38_RS12505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY38_RS12510	COG3118	belongs to the thioredoxin family
GPY38_RS12515	COG0513	Belongs to the DEAD box helicase family
GPY38_RS12520	COG0248	Ppx GppA phosphatase
GPY38_RS12525	COG0784	Response regulator, receiver
GPY38_RS12525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY38_RS12525	COG2205	protein histidine kinase activity
GPY38_RS12525	COG2198	Histidine kinase
GPY38_RS12530	COG2814	Major facilitator Superfamily
GPY38_RS12545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY38_RS12550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY38_RS12555	COG0511	ligase activity, forming carbon-carbon bonds
GPY38_RS12560	COG0439	Biotin carboxylase
GPY38_RS12565	COG2264	protein methyltransferase activity
GPY38_RS12570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY38_RS12575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY38_RS12580	COG0840	transmembrane signaling receptor activity
GPY38_RS12595	COG2207	Transcriptional regulator
GPY38_RS12600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY38_RS12600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY38_RS12600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS12610	COG1940	carbohydrate kinase activity
GPY38_RS12615	COG0789	Transcriptional regulator
GPY38_RS12620	COG0138	bifunctional purine biosynthesis protein purh
GPY38_RS12625	COG0151	Belongs to the GarS family
GPY38_RS12635	COG0776	regulation of translation
GPY38_RS12640	COG1253	flavin adenine dinucleotide binding
GPY38_RS12645	COG0668	transmembrane transport
GPY38_RS12650	COG3068	Protein conserved in bacteria
GPY38_RS12655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY38_RS12660	COG1573	uracil-dna glycosylase
GPY38_RS12680	COG0741	lytic transglycosylase activity
GPY38_RS12690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY38_RS12730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY38_RS12735	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPY38_RS12745	COG0438	transferase activity, transferring glycosyl groups
GPY38_RS12775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY38_RS12820	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY38_RS12825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY38_RS12835	COG1560	Kdo2-lipid A biosynthetic process
GPY38_RS12845	COG0859	PFAM glycosyl transferase family 9
GPY38_RS12850	COG0859	PFAM glycosyl transferase family 9
GPY38_RS12855	COG1519	Transferase
GPY38_RS12860	COG0438	transferase activity, transferring glycosyl groups
GPY38_RS12870	COG0859	PFAM glycosyl transferase family 9
GPY38_RS12875	COG0463	Glycosyl transferase, family 2
GPY38_RS12880	COG0438	transferase activity, transferring glycosyl groups
GPY38_RS12885	COG0438	transferase activity, transferring glycosyl groups
GPY38_RS12890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY38_RS12905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY38_RS12915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY38_RS12940	COG1309	transcriptional regulator
GPY38_RS12945	COG1560	Kdo2-lipid A biosynthetic process
GPY38_RS12950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY38_RS12955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY38_RS12960	COG1561	YicC-like family, N-terminal region
GPY38_RS12975	COG4607	ABC-type enterochelin transport system periplasmic component
GPY38_RS12980	COG1120	ATPase activity
GPY38_RS12985	COG4774	siderophore transport
GPY38_RS12990	COG1132	(ABC) transporter
GPY38_RS13005	COG0514	ATP-dependent DNA helicase (RecQ)
GPY38_RS13010	COG2962	Rard protein
GPY38_RS13025	COG0405	Gamma-glutamyltransferase
GPY38_RS13030	COG0210	DNA helicase
GPY38_RS13065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY38_RS13070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY38_RS13085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY38_RS13090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY38_RS13135	COG0747	negative chemotaxis
GPY38_RS13140	COG4172	Belongs to the ABC transporter superfamily
GPY38_RS13180	COG1309	transcriptional regulator
GPY38_RS13185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY38_RS13190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY38_RS13195	COG2960	long-chain fatty acid transporting porin activity
GPY38_RS13205	COG0583	DNA-binding transcription factor activity
GPY38_RS13250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY38_RS13260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY38_RS13265	COG0408	coproporphyrinogen oxidase activity
GPY38_RS13280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY38_RS13285	COG0551	DNA topoisomerase type I activity
GPY38_RS13290	COG2922	Belongs to the Smg family
GPY38_RS13295	COG0758	DNA mediated transformation
GPY38_RS13305	COG0242	peptide deformylase activity
GPY38_RS13315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY38_RS13315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY38_RS13320	COG0569	domain protein
GPY38_RS13325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY38_RS13335	COG1272	protein, Hemolysin III
GPY38_RS13340	COG4326	sporulation control protein
GPY38_RS13350	COG3084	Protein conserved in bacteria
GPY38_RS13360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY38_RS13365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY38_RS13370	COG0204	Acyl-transferase
GPY38_RS13385	COG1196	nuclear chromosome segregation
GPY38_RS13435	COG3978	acetolactate synthase activity
GPY38_RS13440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY38_RS13455	COG0604	alcohol dehydrogenase
GPY38_RS13465	COG2203	Gaf domain
GPY38_RS13465	COG2199	diguanylate cyclase activity
GPY38_RS13470	COG2199	diguanylate cyclase activity
GPY38_RS13490	COG2119	membrane
GPY38_RS13495	COG0752	glycyl-tRNA synthetase alpha subunit
GPY38_RS13500	COG0751	glycine-tRNA ligase activity
GPY38_RS13505	COG3977	Valine--pyruvate aminotransferase
GPY38_RS13510	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY38_RS13520	COG0187	DNA topoisomerase II activity
GPY38_RS13530	COG0592	DNA-directed DNA polymerase activity
GPY38_RS13535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY38_RS13550	COG1126	abc transporter atp-binding protein
GPY38_RS13555	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY38_RS13565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY38_RS13570	COG0706	membrane insertase activity
GPY38_RS13595	COG4869	propanediol catabolic process
GPY38_RS13600	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GPY38_RS13610	COG1882	Formate acetyltransferase
GPY38_RS13630	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GPY38_RS13635	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GPY38_RS13640	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GPY38_RS13655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY38_RS13660	COG0445	tRNA wobble uridine modification
GPY38_RS13670	COG1192	Involved in chromosome partitioning
GPY38_RS13675	COG1475	DNA binding
GPY38_RS13680	COG3312	ion transport
GPY38_RS13685	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY38_RS13695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY38_RS13700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY38_RS13710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY38_RS13715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY38_RS13720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY38_RS13730	COG0765	amino acid transport
GPY38_RS13740	COG2814	Major facilitator Superfamily
GPY38_RS13745	COG0583	DNA-binding transcription factor activity
GPY38_RS13750	COG0183	Belongs to the thiolase family
GPY38_RS13760	COG1739	Uncharacterized protein family UPF0029
GPY38_RS13810	COG2132	Multicopper oxidase
GPY38_RS13815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY38_RS13820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY38_RS13825	COG0352	thiamine-phosphate diphosphorylase activity
GPY38_RS13830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY38_RS13840	COG2022	thiamine diphosphate biosynthetic process
GPY38_RS13845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY38_RS13850	COG4175	Glycine betaine
GPY38_RS13865	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GPY38_RS13880	COG0006	proline dipeptidase activity
GPY38_RS13880	COG0006	proline dipeptidase activity
GPY38_RS13900	COG1522	sequence-specific DNA binding
GPY38_RS13910	COG0742	ribosomal rna small subunit methyltransferase
GPY38_RS13920	COG0697	spore germination
GPY38_RS13925	COG0589	response to stress
GPY38_RS13930	COG1528	Iron-storage protein
GPY38_RS13940	COG2081	HI0933 family
GPY38_RS13945	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY38_RS13950	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY38_RS13960	COG1879	ABC-type sugar transport system periplasmic component
GPY38_RS13965	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY38_RS13970	COG1129	ABC transporter
GPY38_RS13975	COG1879	ABC-type sugar transport system periplasmic component
GPY38_RS13980	COG1069	ribulokinase activity
GPY38_RS13990	COG2160	L-arabinose isomerase activity
GPY38_RS14015	COG1322	Protein conserved in bacteria
GPY38_RS14020	COG2226	methyltransferase
GPY38_RS14025	COG3165	ubiquinone biosynthetic process from chorismate
GPY38_RS14040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY38_RS14045	COG0805	protein transport
GPY38_RS14065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY38_RS14065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY38_RS14070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY38_RS14095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY38_RS14100	COG3071	HemY protein
GPY38_RS14105	COG2959	enzyme of heme biosynthesis
GPY38_RS14110	COG1587	Uroporphyrinogen-III synthase
GPY38_RS14120	COG3072	Adenylate cyclase
GPY38_RS14150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY38_RS14155	COG1011	Hydrolase
GPY38_RS14180	COG0561	phosphatase activity
GPY38_RS14185	COG2267	carboxylic ester hydrolase activity
GPY38_RS14190	COG1280	lysine exporter protein (LysE YggA)
GPY38_RS14195	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY38_RS14200	COG0640	Transcriptional regulator
GPY38_RS14205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY38_RS14220	COG0783	Belongs to the Dps family
GPY38_RS14250	COG2095	MarC family integral membrane protein
GPY38_RS14260	COG0742	ribosomal rna small subunit methyltransferase
GPY38_RS14265	COG0552	protein localization to endoplasmic reticulum
GPY38_RS14270	COG2884	Cell division ATP-binding protein ftsE
GPY38_RS14275	COG2177	Part of the ABC transporter FtsEX involved in
GPY38_RS14280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY38_RS14285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY38_RS14295	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY38_RS14300	COG3161	chorismate lyase activity
GPY38_RS14305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY38_RS14310	COG2937	Belongs to the GPAT DAPAT family
GPY38_RS14315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY38_RS14320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY38_RS14330	COG0534	Mate efflux family protein
GPY38_RS14405	COG2003	Belongs to the UPF0758 family
GPY38_RS14420	COG3339	Conserved Protein
GPY38_RS14460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY38_RS14475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY38_RS14545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY38_RS14550	COG3300	MHYT domain
GPY38_RS14550	COG5001	Diguanylate cyclase
GPY38_RS14560	COG3852	Histidine kinase
GPY38_RS14570	COG0174	glutamine synthetase
GPY38_RS14595	COG1490	D-aminoacyl-tRNA deacylase activity
GPY38_RS14600	COG0456	acetyltransferase
GPY38_RS14605	COG2982	Protein involved in outer membrane biogenesis
GPY38_RS14610	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY38_RS14620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY38_RS14625	COG3031	protein transport across the cell outer membrane
GPY38_RS14635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY38_RS14640	COG1459	type II secretion system
GPY38_RS14650	COG2165	general secretion pathway protein
GPY38_RS14655	COG2165	general secretion pathway protein
GPY38_RS14660	COG4795	General secretion pathway protein
GPY38_RS14665	COG3156	type II secretion system protein K
GPY38_RS14670	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY38_RS14675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY38_RS14685	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY38_RS14690	COG0494	nUDIX hydrolase
GPY38_RS14695	COG0316	Belongs to the HesB IscA family
GPY38_RS14695	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY38_RS14700	COG1040	competence protein
GPY38_RS14705	COG0596	Alpha beta hydrolase
GPY38_RS14715	COG2183	response to ionizing radiation
GPY38_RS14725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY38_RS14730	COG1609	Transcriptional regulator
GPY38_RS14735	COG0129	dihydroxy-acid dehydratase activity
GPY38_RS14740	COG3265	gluconokinase activity
GPY38_RS14745	COG2610	gluconate transmembrane transporter activity
GPY38_RS14750	COG0800	Aldolase
GPY38_RS14755	COG0745	RESPONSE REGULATOR receiver
GPY38_RS14760	COG2205	protein histidine kinase activity
GPY38_RS14765	COG2233	PERMEase
GPY38_RS14775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY38_RS14780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY38_RS14790	COG0194	GDP metabolic process
GPY38_RS14795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY38_RS14800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY38_RS14835	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY38_RS14840	COG0540	Belongs to the ATCase OTCase family
GPY38_RS14845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY38_RS14860	COG1288	antiporter activity
GPY38_RS14865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY38_RS14870	COG1027	Aspartate ammonia-lyase
GPY38_RS14875	COG3706	GGDEF domain
GPY38_RS14885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY38_RS14890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GPY38_RS14895	COG2205	protein histidine kinase activity
GPY38_RS14900	COG0745	RESPONSE REGULATOR receiver
GPY38_RS14915	COG0205	6-phosphofructokinase activity
GPY38_RS14920	COG1494	fructose-1,6-bisphosphatase
GPY38_RS14930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY38_RS14935	COG0527	aspartate kinase activity
GPY38_RS14935	COG0460	homoserine dehydrogenase
GPY38_RS14940	COG0626	cystathionine gamma-synthase activity
GPY38_RS14950	COG0281	malic enzyme
GPY38_RS14960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY38_RS14965	COG1609	Transcriptional regulator
GPY38_RS14980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY38_RS14985	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY38_RS14990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY38_RS14995	COG0534	Mate efflux family protein
GPY38_RS15000	COG0149	triose-phosphate isomerase activity
GPY38_RS15025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY38_RS15030	COG0459	protein refolding
GPY38_RS15035	COG1119	ATPase activity
GPY38_RS15045	COG1285	pathogenesis
GPY38_RS15050	COG1509	lysine 2,3-aminomutase activity
GPY38_RS15055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY38_RS15060	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY38_RS15065	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY38_RS15070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY38_RS15075	COG1053	succinate dehydrogenase
GPY38_RS15085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY38_RS15090	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY38_RS15100	COG1045	serine acetyltransferase
GPY38_RS15110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY38_RS15115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY38_RS15120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY38_RS15125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY38_RS15135	COG0165	Argininosuccinate lyase
GPY38_RS15135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY38_RS15145	COG0678	peroxiredoxin activity
GPY38_RS15145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY38_RS15155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY38_RS15190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY38_RS15200	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY38_RS15205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY38_RS15215	COG0180	Tryptophanyl-tRNA synthetase
GPY38_RS15230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY38_RS15240	COG1012	belongs to the aldehyde dehydrogenase family
GPY38_RS15250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY38_RS15255	COG3954	Phosphoribulokinase
GPY38_RS15265	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY38_RS15275	COG0488	(ABC) transporter
GPY38_RS15280	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY38_RS15290	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GPY38_RS15295	COG1047	Peptidyl-prolyl cis-trans
GPY38_RS15305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY38_RS15310	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY38_RS15315	COG3083	sulfuric ester hydrolase activity
GPY38_RS15320	COG0557	exoribonuclease II activity
GPY38_RS15325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY38_RS15330	COG0051	transcription antitermination factor activity, RNA binding
GPY38_RS15335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY38_RS15340	COG0088	Forms part of the polypeptide exit tunnel
GPY38_RS15345	COG0089	rRNA binding
GPY38_RS15355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY38_RS15360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY38_RS15375	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY38_RS15380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY38_RS15385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY38_RS15390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY38_RS15395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY38_RS15400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY38_RS15405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY38_RS15410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY38_RS15415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY38_RS15425	COG1841	ribosomal large subunit assembly
GPY38_RS15435	COG0201	protein transport
GPY38_RS15445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY38_RS15450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY38_RS15455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY38_RS15460	COG0202	RNA polymerase activity
GPY38_RS15465	COG0203	ribosomal protein L17
GPY38_RS15475	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY38_RS15480	COG3061	Opacity-associated protein A
GPY38_RS15490	COG2153	protein acetylation
GPY38_RS15495	COG0513	Belongs to the DEAD box helicase family
GPY38_RS15505	COG0737	Belongs to the 5'-nucleotidase family
GPY38_RS15510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY38_RS15510	COG1648	precorrin-2 dehydrogenase activity
GPY38_RS15515	COG0175	sulfate reduction
GPY38_RS15520	COG2895	sulfate adenylyltransferase (ATP) activity
GPY38_RS15525	COG0471	metal ion transport
GPY38_RS15525	COG3273	potassium ion transport
GPY38_RS15530	COG0529	Catalyzes the synthesis of activated sulfate
GPY38_RS15550	COG1136	(ABC) transporter
GPY38_RS15550	COG0577	efflux transmembrane transporter activity
GPY38_RS15565	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY38_RS15570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY38_RS15585	COG2105	PFAM AIG2 family protein
GPY38_RS15595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY38_RS15600	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY38_RS15605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY38_RS15610	COG0163	prenyltransferase activity
GPY38_RS15615	COG4143	(ABC) transporter
GPY38_RS15635	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY38_RS15645	COG1984	allophanate hydrolase subunit 2
GPY38_RS15660	COG4181	ATPase activity
GPY38_RS15670	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY38_RS15675	COG1716	ATPase activity
GPY38_RS15675	COG5001	Diguanylate cyclase
GPY38_RS15725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY38_RS15730	COG5001	Diguanylate cyclase
GPY38_RS15730	COG3300	MHYT domain
GPY38_RS15735	COG0745	RESPONSE REGULATOR receiver
GPY38_RS15735	COG3706	GGDEF domain
GPY38_RS15745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY38_RS15755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY38_RS15760	COG0509	glycine decarboxylation via glycine cleavage system
GPY38_RS15765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY38_RS15765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY38_RS15770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY38_RS15780	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY38_RS15785	COG3122	Protein conserved in bacteria
GPY38_RS15825	COG1280	lysine exporter protein (LysE YggA)
GPY38_RS15835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY38_RS15845	COG2985	domain, Protein
GPY38_RS15860	COG0840	transmembrane signaling receptor activity
GPY38_RS15875	COG0513	Belongs to the DEAD box helicase family
GPY38_RS15885	COG1280	lysine exporter protein (LysE YggA)
GPY38_RS15935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY38_RS15945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY38_RS15950	COG0798	PFAM Bile acid sodium symporter
GPY38_RS15955	COG0583	DNA-binding transcription factor activity
GPY38_RS15975	COG0579	oxidoreductase
GPY38_RS15980	COG3121	Chaperone
GPY38_RS16010	COG0110	maltose O-acetyltransferase activity
GPY38_RS16020	COG1765	OsmC-like protein
GPY38_RS16040	COG2205	protein histidine kinase activity
GPY38_RS16040	COG5002	protein histidine kinase activity
GPY38_RS16040	COG0784	Response regulator, receiver
GPY38_RS16065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY38_RS16070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY38_RS16095	COG1522	sequence-specific DNA binding
GPY38_RS16110	COG0748	coenzyme F420 binding
GPY38_RS16115	COG3721	Heme iron utilization protein
GPY38_RS16125	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY38_RS16135	COG0848	biopolymer transport protein
GPY38_RS16145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY38_RS16150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY38_RS16185	COG0418	dihydroorotase activity
GPY38_RS16190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY38_RS16195	COG2354	Protein conserved in bacteria
GPY38_RS16215	COG1349	DNA-binding transcription factor activity
GPY38_RS16255	COG3842	ATPase activity
GPY38_RS16295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY38_RS16305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY38_RS16325	COG0517	IMP dehydrogenase activity
GPY38_RS16335	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS16345	COG1917	Cupin 2, conserved barrel domain protein
GPY38_RS16375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GPY38_RS16380	COG1070	Carbohydrate kinase
GPY38_RS16385	COG4806	L-rhamnose isomerase
GPY38_RS16390	COG3254	rhamnose metabolic process
GPY38_RS16395	COG0235	Class ii aldolase
GPY38_RS16405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY38_RS16410	COG0800	Aldolase
GPY38_RS16420	COG0840	transmembrane signaling receptor activity
GPY38_RS16435	COG1175	transmembrane transport
GPY38_RS16440	COG0395	ABC-type sugar transport system, permease component
GPY38_RS16445	COG3842	ATPase activity
GPY38_RS16450	COG1653	transport
GPY38_RS16460	COG0534	Mate efflux family protein
GPY38_RS16465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY38_RS16470	COG0823	Involved in the tonB-independent uptake of proteins
GPY38_RS16475	COG0393	Putative heavy-metal-binding
GPY38_RS16485	COG1929	Belongs to the glycerate kinase type-1 family
GPY38_RS16490	COG0383	alpha-mannosidase activity
GPY38_RS16495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY38_RS16495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY38_RS16495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS16500	COG2188	Transcriptional regulator
GPY38_RS16530	COG5001	Diguanylate cyclase
GPY38_RS16530	COG3300	MHYT domain
GPY38_RS16535	COG2271	Major facilitator Superfamily
GPY38_RS16540	COG0584	glycerophosphoryl diester phosphodiesterase
GPY38_RS16545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY38_RS16550	COG0583	DNA-binding transcription factor activity
GPY38_RS16555	COG1609	Transcriptional regulator
GPY38_RS16560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY38_RS16565	COG1879	ABC-type sugar transport system periplasmic component
GPY38_RS16570	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY38_RS16575	COG1129	ABC transporter
GPY38_RS16580	COG1869	D-ribose catabolic process
GPY38_RS16695	COG1846	Transcriptional regulator
GPY38_RS16710	COG0564	pseudouridine synthase activity
GPY38_RS16715	COG1309	transcriptional regulator
GPY38_RS16720	COG2130	NADP-dependent
GPY38_RS16735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY38_RS16765	COG3842	ATPase activity
GPY38_RS16775	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY38_RS16780	COG0656	L-ascorbic acid biosynthetic process
GPY38_RS16785	COG1902	pentaerythritol trinitrate reductase activity
GPY38_RS16790	COG0583	DNA-binding transcription factor activity
GPY38_RS16795	COG2814	Major facilitator Superfamily
GPY38_RS16815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY38_RS16830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY38_RS16840	COG4702	Belongs to the UPF0303 family
GPY38_RS16845	COG0673	inositol 2-dehydrogenase activity
GPY38_RS16850	COG1349	DNA-binding transcription factor activity
GPY38_RS16860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY38_RS16880	COG3240	lipase activity
GPY38_RS16885	COG3477	response to acidic pH
GPY38_RS16890	COG0697	spore germination
GPY38_RS16895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY38_RS16910	COG2207	Transcriptional regulator
GPY38_RS16910	COG1917	Cupin 2, conserved barrel domain protein
GPY38_RS16930	COG3447	MASE1 domain protein
GPY38_RS16930	COG5001	Diguanylate cyclase
GPY38_RS16930	COG5002	protein histidine kinase activity
GPY38_RS16940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY38_RS16955	COG0109	protoheme IX farnesyltransferase activity
GPY38_RS16960	COG1612	heme a metabolic process
GPY38_RS16990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY38_RS17000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY38_RS17005	COG1902	pentaerythritol trinitrate reductase activity
GPY38_RS17015	COG1280	lysine exporter protein (LysE YggA)
GPY38_RS17035	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPY38_RS17040	COG1846	Transcriptional regulator
GPY38_RS17045	COG1764	response to oxidative stress
GPY38_RS17065	COG2814	Major facilitator Superfamily
GPY38_RS17070	COG0583	DNA-binding transcription factor activity
GPY38_RS17075	COG5001	Diguanylate cyclase
GPY38_RS17080	COG0739	heme binding
GPY38_RS17095	COG0659	secondary active sulfate transmembrane transporter activity
GPY38_RS17110	COG2199	diguanylate cyclase activity
GPY38_RS17120	COG0581	inorganic phosphate transmembrane transporter activity
GPY38_RS17125	COG0573	inorganic phosphate transmembrane transporter activity
GPY38_RS17130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY38_RS17140	COG0513	Belongs to the DEAD box helicase family
GPY38_RS17150	COG1376	ErfK ybiS ycfS ynhG family protein
GPY38_RS17150	COG1388	LysM domain
GPY38_RS17165	COG3272	Protein of unknown function (DUF1722)
GPY38_RS17170	COG0813	purine-nucleoside phosphorylase activity
GPY38_RS17185	COG3706	GGDEF domain
GPY38_RS17195	COG1566	PFAM secretion protein HlyD family protein
GPY38_RS17230	COG0786	glutamate:sodium symporter activity
GPY38_RS17255	COG1162	GTPase activity
GPY38_RS17260	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY38_RS17275	COG4580	involved in the transport of maltose and maltodextrins
GPY38_RS17285	COG1132	(ABC) transporter
GPY38_RS17305	COG3383	formate dehydrogenase (NAD+) activity
GPY38_RS17320	COG0840	transmembrane signaling receptor activity
GPY38_RS17330	COG1131	(ABC) transporter
GPY38_RS17335	COG2188	Transcriptional regulator
GPY38_RS17345	COG3033	Beta-eliminating lyase
GPY38_RS17350	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY38_RS17355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY38_RS17360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY38_RS17365	COG0471	metal ion transport
GPY38_RS17390	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GPY38_RS17410	COG3501	Rhs element vgr protein
GPY38_RS17420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY38_RS17425	COG1640	4-alpha-glucanotransferase
GPY38_RS17430	COG0058	SHG alpha-glucan phosphorylase activity
GPY38_RS17445	COG0109	protoheme IX farnesyltransferase activity
GPY38_RS17450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY38_RS17455	COG1845	cytochrome c oxidase, subunit III
GPY38_RS17460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY38_RS17465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY38_RS17480	COG2084	Dehydrogenase
GPY38_RS17495	COG0217	transcriptional regulatory protein
GPY38_RS17525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY38_RS17530	COG1444	tRNA N-acetyltransferase activity
GPY38_RS17540	COG0745	RESPONSE REGULATOR receiver
GPY38_RS17545	COG0643	Histidine kinase
GPY38_RS17545	COG2198	Histidine kinase
GPY38_RS17550	COG0835	chemotaxis
GPY38_RS17555	COG0835	chemotaxis
GPY38_RS17560	COG0840	transmembrane signaling receptor activity
GPY38_RS17565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY38_RS17570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPY38_RS17575	COG2201	protein-glutamate methylesterase activity
GPY38_RS17590	COG0745	RESPONSE REGULATOR receiver
GPY38_RS17600	COG0259	pyridoxamine-phosphate oxidase activity
GPY38_RS17610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY38_RS17645	COG0840	transmembrane signaling receptor activity
GPY38_RS17660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY38_RS17670	COG0513	Belongs to the DEAD box helicase family
GPY38_RS17680	COG0583	DNA-binding transcription factor activity
GPY38_RS17685	COG2226	methyltransferase
GPY38_RS17705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY38_RS17725	COG0724	RNA recognition motif
GPY38_RS17730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY38_RS17735	COG1522	sequence-specific DNA binding
GPY38_RS17740	COG2610	gluconate transmembrane transporter activity
GPY38_RS17745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY38_RS17750	COG3622	Belongs to the hyi family
GPY38_RS17755	COG0235	Class ii aldolase
GPY38_RS17760	COG3395	kinase activity
GPY38_RS17765	COG2084	Dehydrogenase
GPY38_RS17770	COG1349	DNA-binding transcription factor activity
GPY38_RS17785	COG0583	DNA-binding transcription factor activity
GPY38_RS17790	COG2910	NAD(P)H-binding
GPY38_RS17805	COG1335	isochorismatase
GPY38_RS17825	COG2329	Antibiotic biosynthesis monooxygenase
GPY38_RS17830	COG3304	Inner membrane component domain
GPY38_RS17840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY38_RS17845	COG3706	GGDEF domain
GPY38_RS17860	COG0583	DNA-binding transcription factor activity
GPY38_RS17865	COG4221	oxidoreductase activity
GPY38_RS17890	COG0583	DNA-binding transcription factor activity
GPY38_RS17895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY38_RS17905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY38_RS17910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY38_RS17915	COG2814	Major facilitator Superfamily
GPY38_RS17925	COG3118	belongs to the thioredoxin family
GPY38_RS17930	COG3118	belongs to the thioredoxin family
GPY38_RS17935	COG0492	ferredoxin-NADP+ reductase activity
GPY38_RS17940	COG1309	transcriptional regulator
GPY38_RS17950	COG2176	DNA-directed DNA polymerase activity
GPY38_RS17970	COG0443	Heat shock 70 kDa protein
GPY38_RS17975	COG0095	Lipoate-protein ligase
GPY38_RS17980	COG0243	molybdopterin cofactor binding
GPY38_RS17985	COG0437	4 iron, 4 sulfur cluster binding
GPY38_RS17990	COG3302	dmso reductase anchor subunit
GPY38_RS18000	COG2221	Nitrite and sulphite reductase 4Fe-4S
GPY38_RS18000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY38_RS18010	COG0583	DNA-binding transcription factor activity
GPY38_RS18015	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY38_RS18020	COG1473	amidohydrolase
GPY38_RS18035	COG2376	Dihydroxyacetone kinase
GPY38_RS18040	COG1461	Dihydroxyacetone kinase
GPY38_RS18050	COG3284	Transcriptional regulator
GPY38_RS18060	COG3722	fumarate hydratase activity
GPY38_RS18065	COG0246	Mannitol dehydrogenase
GPY38_RS18070	COG2213	PTS system mannitol-specific
GPY38_RS18070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS18075	COG0739	heme binding
GPY38_RS18090	COG0363	glucosamine-6-phosphate deaminase activity
GPY38_RS18115	COG0402	S-adenosylhomocysteine deaminase activity
GPY38_RS18120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY38_RS18125	COG2259	Doxx family
GPY38_RS18130	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY38_RS18135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY38_RS18145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY38_RS18150	COG1301	dicarboxylic acid transport
GPY38_RS18155	COG2169	Transcriptional regulator
GPY38_RS18155	COG1917	Cupin 2, conserved barrel domain protein
GPY38_RS18185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY38_RS18195	COG0583	DNA-binding transcription factor activity
GPY38_RS18200	COG1342	Belongs to the UPF0251 family
GPY38_RS18210	COG0583	DNA-binding transcription factor activity
GPY38_RS18215	COG3384	dioxygenase
GPY38_RS18230	COG4774	siderophore transport
GPY38_RS18235	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY38_RS18240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY38_RS18245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY38_RS18250	COG1120	ATPase activity
GPY38_RS18260	COG0583	DNA-binding transcription factor activity
GPY38_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS18275	COG0024	Methionine aminopeptidase
GPY38_RS18280	COG0519	Catalyzes the synthesis of GMP from XMP
GPY38_RS18290	COG1403	HNH endonuclease
GPY38_RS18305	COG3152	Membrane
GPY38_RS18325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY38_RS18350	COG1304	FMN binding
GPY38_RS18355	COG1620	l-lactate permease
GPY38_RS18360	COG0583	DNA-binding transcription factor activity
GPY38_RS18365	COG4172	Belongs to the ABC transporter superfamily
GPY38_RS18375	COG1067	ATP-dependent peptidase activity
GPY38_RS18380	COG0840	transmembrane signaling receptor activity
GPY38_RS18385	COG2211	Major facilitator Superfamily
GPY38_RS18390	COG0668	transmembrane transport
GPY38_RS18395	COG0569	domain protein
GPY38_RS18400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY38_RS18410	COG3123	guanosine phosphorylase activity
GPY38_RS18420	COG2814	Major facilitator Superfamily
GPY38_RS18430	COG3501	Rhs element vgr protein
GPY38_RS18535	COG0745	RESPONSE REGULATOR receiver
GPY38_RS18540	COG1741	Belongs to the pirin family
GPY38_RS18595	COG3706	GGDEF domain
GPY38_RS18605	COG1846	Transcriptional regulator
GPY38_RS18610	COG2315	Protein conserved in bacteria
GPY38_RS18615	COG0835	chemotaxis
GPY38_RS18615	COG0784	Response regulator, receiver
GPY38_RS18620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY38_RS18660	COG0251	oxidation-reduction process
GPY38_RS18700	COG1522	sequence-specific DNA binding
GPY38_RS18710	COG2204	response regulator
GPY38_RS18725	COG0579	oxidoreductase
GPY38_RS18735	COG3530	Putative quorum-sensing-regulated virulence factor
GPY38_RS18745	COG0589	response to stress
GPY38_RS18750	COG3171	Protein conserved in bacteria
GPY38_RS18775	COG0583	DNA-binding transcription factor activity
GPY38_RS18800	COG4948	Mandelate Racemase Muconate Lactonizing
GPY38_RS18825	COG1012	belongs to the aldehyde dehydrogenase family
GPY38_RS18830	COG3724	N-succinylarginine dihydrolase activity
GPY38_RS18840	COG3706	GGDEF domain
GPY38_RS18840	COG0745	RESPONSE REGULATOR receiver
GPY38_RS18845	COG5002	protein histidine kinase activity
GPY38_RS18845	COG2205	protein histidine kinase activity
GPY38_RS18845	COG0784	Response regulator, receiver
GPY38_RS18855	COG5001	Diguanylate cyclase
GPY38_RS18870	COG2304	oxidoreductase activity
GPY38_RS18890	COG0714	Associated with various cellular activities
GPY38_RS18895	COG0840	transmembrane signaling receptor activity
GPY38_RS18910	COG0366	Alpha amylase catalytic
GPY38_RS18925	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY38_RS18935	COG3604	Transcriptional regulator
GPY38_RS18940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY38_RS18940	COG1017	nitric oxide dioxygenase activity
GPY38_RS18945	COG3706	GGDEF domain
GPY38_RS18950	COG4681	YaeQ
GPY38_RS18955	COG1278	Cold shock
GPY38_RS18960	COG3036	rescue of stalled ribosome
GPY38_RS19000	COG2197	response regulator
GPY38_RS19010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY38_RS19010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY38_RS19015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY38_RS19070	COG0745	RESPONSE REGULATOR receiver
GPY38_RS19085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY38_RS19090	COG3186	Phenylalanine-4-hydroxylase
GPY38_RS19095	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY38_RS19100	COG0534	Mate efflux family protein
GPY38_RS19110	COG0861	Integral membrane protein TerC family
GPY38_RS19120	COG0456	acetyltransferase
GPY38_RS19125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY38_RS19130	COG0662	Cupin 2, conserved barrel domain protein
GPY38_RS19135	COG0527	aspartate kinase activity
GPY38_RS19160	COG0784	Response regulator, receiver
GPY38_RS19160	COG3437	response regulator, receiver
GPY38_RS19170	COG0113	porphobilinogen synthase activity
GPY38_RS19185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY38_RS19190	COG2239	Acts as a magnesium transporter
GPY38_RS19210	COG2113	Glycine betaine
GPY38_RS19215	COG4176	ABC-type proline glycine betaine transport system permease component
GPY38_RS19220	COG4175	Glycine betaine
GPY38_RS19230	COG1166	arginine decarboxylase activity
GPY38_RS19240	COG1522	sequence-specific DNA binding
GPY38_RS19255	COG0765	amino acid transport
GPY38_RS19265	COG1686	Belongs to the peptidase S11 family
GPY38_RS19280	COG1566	PFAM secretion protein HlyD family protein
GPY38_RS19300	COG3121	Chaperone
GPY38_RS19305	COG3188	usher protein
GPY38_RS19360	COG4533	DNA binding
GPY38_RS19370	COG3835	regulator
GPY38_RS19375	COG2610	gluconate transmembrane transporter activity
GPY38_RS19395	COG0531	amino acid
GPY38_RS19400	COG1410	methionine synthase
GPY38_RS19400	COG0646	methionine synthase
GPY38_RS19430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY38_RS19435	COG0363	glucosamine-6-phosphate deaminase activity
GPY38_RS19440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY38_RS19445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY38_RS19455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY38_RS19475	COG0346	lactoylglutathione lyase activity
GPY38_RS19485	COG3284	Transcriptional regulator
GPY38_RS19490	COG1012	belongs to the aldehyde dehydrogenase family
GPY38_RS19495	COG0156	8-amino-7-oxononanoate synthase activity
GPY38_RS19500	COG1063	alcohol dehydrogenase
GPY38_RS19505	COG1278	Cold shock
GPY38_RS19525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY38_RS19540	COG1132	(ABC) transporter
GPY38_RS19545	COG1132	(ABC) transporter
GPY38_RS19555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY38_RS19560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY38_RS19565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY38_RS19570	COG1116	anion transmembrane transporter activity
GPY38_RS19575	COG0351	phosphomethylpyrimidine kinase
GPY38_RS19590	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GPY38_RS19625	COG3047	cAMP biosynthetic process
GPY38_RS19630	COG3227	Zinc metalloprotease (Elastase)
GPY38_RS19650	COG4989	oxidoreductase activity
GPY38_RS19655	COG3275	phosphorelay sensor kinase activity
GPY38_RS19660	COG3279	Response regulator of the LytR AlgR family
GPY38_RS19665	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY38_RS19685	COG0840	transmembrane signaling receptor activity
GPY38_RS19695	COG2814	Major facilitator Superfamily
GPY38_RS19715	COG1522	sequence-specific DNA binding
GPY38_RS19720	COG0840	transmembrane signaling receptor activity
GPY38_RS19725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY38_RS19730	COG5380	lipid catabolic process
GPY38_RS19735	COG3291	Pkd domain containing protein
GPY38_RS19735	COG4412	M6 family metalloprotease domain protein
GPY38_RS19745	COG0121	glutamine amidotransferase
GPY38_RS19755	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY38_RS19760	COG4605	iron ion homeostasis
GPY38_RS19765	COG4604	ABC transporter, ATP-binding protein
GPY38_RS19785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY38_RS19790	COG2207	Transcriptional regulator
GPY38_RS19790	COG1917	Cupin 2, conserved barrel domain protein
GPY38_RS19810	COG0330	HflC and HflK could
GPY38_RS19820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPY38_RS19835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY38_RS19840	COG0583	DNA-binding transcription factor activity
GPY38_RS19845	COG3781	membrane
GPY38_RS19855	COG1271	oxidase subunit
GPY38_RS19860	COG1294	oxidase, subunit
GPY38_RS19870	COG2390	Transcriptional regulator
GPY38_RS19880	COG1070	Carbohydrate kinase
GPY38_RS19890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY38_RS19905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY38_RS19915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY38_RS19925	COG1120	ATPase activity
GPY38_RS19930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY38_RS19960	COG1126	abc transporter atp-binding protein
GPY38_RS19965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY38_RS19970	COG4215	(ABC) transporter
GPY38_RS19975	COG4160	amino acid transport
GPY38_RS19980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY38_RS20000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY38_RS20005	COG2146	nitrite reductase [NAD(P)H] activity
GPY38_RS20015	COG1648	precorrin-2 dehydrogenase activity
GPY38_RS20015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY38_RS20040	COG2814	Major facilitator Superfamily
GPY38_RS20045	COG3118	belongs to the thioredoxin family
GPY38_RS20050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY38_RS20065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY38_RS20105	COG0438	transferase activity, transferring glycosyl groups
GPY38_RS20105	COG0297	glycogen (starch) synthase activity
GPY38_RS20120	COG0247	lactate metabolic process
GPY38_RS20125	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY38_RS20130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY38_RS20135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY38_RS20190	COG4386	tail sheath protein
GPY38_RS20230	COG4695	Portal protein
GPY38_RS20365	COG4974	Belongs to the 'phage' integrase family
GPY38_RS20385	COG2827	Endonuclease containing a URI domain
GPY38_RS20390	COG1879	ABC-type sugar transport system periplasmic component
GPY38_RS20395	COG0784	Response regulator, receiver
GPY38_RS20395	COG5002	protein histidine kinase activity
GPY38_RS20420	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY38_RS20425	COG4149	molybdate abc transporter
GPY38_RS20430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY38_RS20445	COG1289	transmembrane transporter activity
GPY38_RS20485	COG0210	DNA helicase
GPY38_RS20490	COG1335	isochorismatase
GPY38_RS20495	COG1803	Methylglyoxal synthase
GPY38_RS20500	COG1879	ABC-type sugar transport system periplasmic component
GPY38_RS20505	COG2198	Histidine kinase
GPY38_RS20505	COG0784	Response regulator, receiver
GPY38_RS20505	COG2205	protein histidine kinase activity
GPY38_RS20515	COG1979	alcohol dehydrogenase
GPY38_RS20520	COG2207	Transcriptional regulator
GPY38_RS20535	COG3706	GGDEF domain
GPY38_RS20555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY38_RS20560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY38_RS20570	COG0183	Belongs to the thiolase family
GPY38_RS20590	COG4166	transmembrane transport
GPY38_RS20600	COG3005	denitrification pathway
GPY38_RS20610	COG0243	molybdopterin cofactor binding
GPY38_RS20630	COG2197	response regulator
GPY38_RS20635	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY38_RS20650	COG2814	Major facilitator Superfamily
GPY38_RS20655	COG0840	transmembrane signaling receptor activity
GPY38_RS20665	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY38_RS20680	COG0840	transmembrane signaling receptor activity
GPY38_RS20685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY38_RS20695	COG0745	RESPONSE REGULATOR receiver
GPY38_RS20700	COG1280	lysine exporter protein (LysE YggA)
GPY38_RS20705	COG0583	DNA-binding transcription factor activity
GPY38_RS20710	COG1566	PFAM secretion protein HlyD family protein
GPY38_RS20745	COG1902	pentaerythritol trinitrate reductase activity
GPY38_RS20750	COG1073	alpha beta
GPY38_RS20755	COG1073	alpha beta
GPY38_RS20765	COG2207	Transcriptional regulator
GPY38_RS20775	COG0454	-acetyltransferase
GPY38_RS20820	COG1328	CTP reductase activity
GPY38_RS20825	COG0602	queuosine metabolic process
GPY38_RS20835	COG0189	ligase activity
GPY38_RS20835	COG4067	protein conserved in archaea
GPY38_RS20840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY38_RS20840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY38_RS20840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY38_RS20845	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY38_RS20850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS20850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY38_RS20855	COG1609	Transcriptional regulator
GPY38_RS20860	COG0420	3'-5' exonuclease activity
GPY38_RS20865	COG0419	ATPase involved in DNA repair
GPY38_RS20870	COG2205	protein histidine kinase activity
GPY38_RS20870	COG0784	Response regulator, receiver
GPY38_RS20875	COG0156	8-amino-7-oxononanoate synthase activity
GPY38_RS20885	COG0038	chloride channel
GPY38_RS20890	COG0523	cobalamin synthesis protein
GPY38_RS20895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY38_RS20900	COG1846	Transcriptional regulator
GPY38_RS20910	COG1064	alcohol dehydrogenase
GPY38_RS20915	COG2207	Transcriptional regulator
GPY38_RS20925	COG3437	response regulator, receiver
GPY38_RS20935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY38_RS20940	COG0243	molybdopterin cofactor binding
GPY38_RS20950	COG5001	Diguanylate cyclase
GPY38_RS20975	COG3038	cytochrome b561
GPY38_RS20985	COG2116	formate transmembrane transporter activity
GPY38_RS20990	COG0583	DNA-binding transcription factor activity
GPY38_RS21000	COG3593	DNA synthesis involved in DNA repair
GPY38_RS21005	COG0737	Belongs to the 5'-nucleotidase family
GPY38_RS21020	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY38_RS21025	COG4783	chaperone-mediated protein folding
GPY38_RS21030	COG2050	protein possibly involved in aromatic compounds catabolism
GPY38_RS21040	COG4533	DNA binding
GPY38_RS21050	COG4771	TonB-dependent receptor
GPY38_RS21050	COG1629	transport
GPY38_RS21055	COG0583	DNA-binding transcription factor activity
GPY38_RS21060	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY38_RS21060	COG1042	CoA-binding domain protein
GPY38_RS21060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY38_RS21070	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY38_RS21085	COG0023	Translation Initiation Factor
GPY38_RS21125	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY38_RS21130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY38_RS21145	COG2199	diguanylate cyclase activity
GPY38_RS21155	COG3706	GGDEF domain
GPY38_RS21165	COG1309	transcriptional regulator
GPY38_RS21170	COG1129	ABC transporter
GPY38_RS21210	COG2351	hydroxyisourate hydrolase activity
GPY38_RS21235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY38_RS21265	COG0765	amino acid transport
GPY38_RS21270	COG0765	amino acid transport
GPY38_RS21300	COG2233	PERMEase
GPY38_RS21310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY38_RS21310	COG2207	Transcriptional regulator
GPY38_RS21315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY38_RS21330	COG4106	trans-aconitate 2-methyltransferase activity
GPY38_RS21350	COG3710	Transcriptional regulator
GPY38_RS21395	COG2501	S4 domain
GPY38_RS21410	COG2199	diguanylate cyclase activity
GPY38_RS21420	COG2203	Gaf domain
GPY38_RS21420	COG3706	GGDEF domain
GPY38_RS21420	COG4251	negative regulation of phosphorylation
GPY38_RS21420	COG5001	Diguanylate cyclase
GPY38_RS21425	COG0784	Response regulator, receiver
GPY38_RS21425	COG2205	protein histidine kinase activity
GPY38_RS21440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY38_RS21445	COG4172	Belongs to the ABC transporter superfamily
GPY38_RS21455	COG4174	ABC transporter (Permease)
GPY38_RS21460	COG4166	transmembrane transport
GPY38_RS21485	COG2866	Carboxypeptidase
GPY38_RS21505	COG3842	ATPase activity
GPY38_RS21515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY38_RS21525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY38_RS21535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY38_RS21540	COG1011	Hydrolase
GPY38_RS21555	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY38_RS21560	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY38_RS21565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY38_RS21565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY38_RS21575	COG4303	Ethanolamine ammonia lyase large subunit
GPY38_RS21585	COG0531	amino acid
GPY38_RS21590	COG0302	gtp cyclohydrolase
GPY38_RS21600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY38_RS21605	COG2897	thiosulfate sulfurtransferase activity
GPY38_RS21620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY38_RS21630	COG0583	DNA-binding transcription factor activity
GPY38_RS21640	COG1309	transcriptional regulator
GPY38_RS21645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY38_RS21675	COG1335	isochorismatase
GPY38_RS21685	COG0456	acetyltransferase
GPY38_RS21695	COG1280	lysine exporter protein (LysE YggA)
GPY38_RS21700	COG0494	nUDIX hydrolase
GPY38_RS21710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY38_RS21745	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS21755	COG0454	-acetyltransferase
GPY38_RS21810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY38_RS21815	COG0789	Transcriptional regulator
GPY38_RS21855	COG4628	conserved protein (DUF2132)
GPY38_RS21860	COG4633	Protein conserved in bacteria
GPY38_RS21885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY38_RS21890	COG0513	Belongs to the DEAD box helicase family
GPY38_RS21895	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY38_RS21905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY38_RS21915	COG0583	DNA-binding transcription factor activity
GPY38_RS21960	COG0318	PFAM AMP-dependent synthetase and ligase
GPY38_RS21965	COG2995	paraquat-inducible protein a
GPY38_RS21970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY38_RS21970	COG3008	intermembrane lipid transfer
GPY38_RS21985	COG0110	maltose O-acetyltransferase activity
GPY38_RS21990	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GPY38_RS22000	COG4232	protein-disulfide reductase activity
GPY38_RS22005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY38_RS22010	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY38_RS22020	COG1252	NADH dehydrogenase
GPY38_RS22060	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS22130	COG0454	-acetyltransferase
GPY38_RS22275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GPY38_RS22295	COG2207	Transcriptional regulator
GPY38_RS22315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY38_RS22325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY38_RS22350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY38_RS22365	COG2423	ornithine cyclodeaminase activity
GPY38_RS22375	COG4145	pantothenate transmembrane transporter activity
GPY38_RS22380	COG0583	DNA-binding transcription factor activity
GPY38_RS22385	COG0435	Glutathione S-transferase
GPY38_RS22390	COG0400	carboxylic ester hydrolase activity
GPY38_RS22395	COG1280	lysine exporter protein (LysE YggA)
GPY38_RS22410	COG1473	amidohydrolase
GPY38_RS22430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY38_RS22435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY38_RS22440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY38_RS22450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY38_RS22465	COG2721	sulfolactate sulfo-lyase activity
GPY38_RS22520	COG0625	glutathione transferase activity
GPY38_RS22525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY38_RS22535	COG0573	inorganic phosphate transmembrane transporter activity
GPY38_RS22560	COG1464	Belongs to the NlpA lipoprotein family
GPY38_RS22565	COG1454	alcohol dehydrogenase
GPY38_RS22570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY38_RS22570	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY38_RS22590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY38_RS22605	COG0653	protein targeting
GPY38_RS22610	COG2814	Major facilitator Superfamily
GPY38_RS22620	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS22630	COG1028	Short-chain dehydrogenase reductase Sdr
GPY38_RS22640	COG1024	Enoyl-CoA hydratase
GPY38_RS22645	COG1024	Enoyl-CoA hydratase
GPY38_RS22650	COG1960	acyl-CoA dehydrogenase activity
GPY38_RS22660	COG0183	Belongs to the thiolase family
GPY38_RS22675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY38_RS22680	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY38_RS22695	COG0450	alkyl hydroperoxide reductase
GPY38_RS22700	COG3634	alkyl hydroperoxide reductase activity
GPY38_RS22710	COG2207	Transcriptional regulator
GPY38_RS22710	COG1609	Transcriptional regulator
GPY38_RS22715	COG1454	alcohol dehydrogenase
GPY38_RS22720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY38_RS22725	COG0406	alpha-ribazole phosphatase activity
GPY38_RS22735	COG0697	spore germination
GPY38_RS22740	COG0583	DNA-binding transcription factor activity
GPY38_RS22755	COG0840	transmembrane signaling receptor activity
GPY38_RS22785	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY38_RS22800	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY38_RS22810	COG1309	transcriptional regulator
GPY38_RS22815	COG0513	Belongs to the DEAD box helicase family
GPY38_RS22820	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP