locus-tag	class	description
VFU_RS00010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VFU_RS00015	COG0049	tRNA binding
VFU_RS00020	COG2168	tRNA wobble position uridine thiolation
VFU_RS00025	COG2923	Belongs to the DsrF TusC family
VFU_RS00035	COG2964	Protein conserved in bacteria
VFU_RS00040	COG0545	Peptidyl-prolyl cis-trans isomerase
VFU_RS00050	COG2900	Belongs to the SlyX family
VFU_RS00055	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VFU_RS00060	COG0330	HflC and HflK could
VFU_RS00065	COG0330	HflC and HflK could
VFU_RS00070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VFU_RS00080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VFU_RS00085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VFU_RS00095	COG0802	atpase or kinase
VFU_RS00100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VFU_RS00155	COG1162	GTPase activity
VFU_RS00160	COG0688	phosphatidylethanolamine metabolic process
VFU_RS00165	COG0490	domain, Protein
VFU_RS00165	COG0471	metal ion transport
VFU_RS00170	COG0840	transmembrane signaling receptor activity
VFU_RS00180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VFU_RS00185	COG4942	peptidase
VFU_RS00200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VFU_RS00205	COG2816	NAD+ diphosphatase activity
VFU_RS00210	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VFU_RS00215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VFU_RS00220	COG0085	RNA polymerase activity
VFU_RS00225	COG0222	ribosome binding
VFU_RS00230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VFU_RS00245	COG0250	Participates in transcription elongation, termination and antitermination
VFU_RS00250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VFU_RS00280	COG1072	(Pantothenic acid kinase))
VFU_RS00290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VFU_RS00300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VFU_RS00345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VFU_RS00360	COG3118	belongs to the thioredoxin family
VFU_RS00365	COG0513	Belongs to the DEAD box helicase family
VFU_RS00370	COG0248	Ppx GppA phosphatase
VFU_RS00375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VFU_RS00375	COG2205	protein histidine kinase activity
VFU_RS00375	COG2198	Histidine kinase
VFU_RS00375	COG0784	Response regulator, receiver
VFU_RS00380	COG2814	Major facilitator Superfamily
VFU_RS00395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VFU_RS00400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VFU_RS00405	COG0511	ligase activity, forming carbon-carbon bonds
VFU_RS00410	COG0439	Biotin carboxylase
VFU_RS00415	COG2264	protein methyltransferase activity
VFU_RS00420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VFU_RS00425	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VFU_RS00430	COG0840	transmembrane signaling receptor activity
VFU_RS00445	COG2207	Transcriptional regulator
VFU_RS00450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VFU_RS00450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VFU_RS00450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VFU_RS00460	COG1940	carbohydrate kinase activity
VFU_RS00465	COG0789	Transcriptional regulator
VFU_RS00470	COG0138	bifunctional purine biosynthesis protein purh
VFU_RS00475	COG0151	Belongs to the GarS family
VFU_RS00485	COG0776	regulation of translation
VFU_RS00490	COG1253	flavin adenine dinucleotide binding
VFU_RS00495	COG0668	transmembrane transport
VFU_RS00500	COG3068	Protein conserved in bacteria
VFU_RS00505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VFU_RS00510	COG1573	uracil-dna glycosylase
VFU_RS00530	COG0741	lytic transglycosylase activity
VFU_RS00540	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VFU_RS00545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VFU_RS00550	COG3562	capsule polysaccharide
VFU_RS00555	COG0438	transferase activity, transferring glycosyl groups
VFU_RS00560	COG0438	transferase activity, transferring glycosyl groups
VFU_RS00570	COG0438	transferase activity, transferring glycosyl groups
VFU_RS00570	COG4641	Protein conserved in bacteria
VFU_RS00580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VFU_RS00595	COG1028	Short-chain dehydrogenase reductase Sdr
VFU_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
VFU_RS00615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VFU_RS00645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VFU_RS00665	COG0438	transferase activity, transferring glycosyl groups
VFU_RS00695	COG0489	protein tyrosine kinase activity
VFU_RS00695	COG3206	protein involved in exopolysaccharide biosynthesis
VFU_RS00725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VFU_RS00730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VFU_RS00740	COG1560	Kdo2-lipid A biosynthetic process
VFU_RS00755	COG0438	transferase activity, transferring glycosyl groups
VFU_RS00770	COG0859	PFAM glycosyl transferase family 9
VFU_RS00775	COG1519	Transferase
VFU_RS00780	COG3642	lipopolysaccharide core region biosynthetic process
VFU_RS00785	COG0859	PFAM glycosyl transferase family 9
VFU_RS00790	COG0463	Glycosyl transferase, family 2
VFU_RS00795	COG0438	transferase activity, transferring glycosyl groups
VFU_RS00800	COG0438	transferase activity, transferring glycosyl groups
VFU_RS00805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VFU_RS00820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VFU_RS00830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VFU_RS00835	COG2003	Belongs to the UPF0758 family
VFU_RS00850	COG1309	transcriptional regulator
VFU_RS00855	COG1560	Kdo2-lipid A biosynthetic process
VFU_RS00865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VFU_RS00870	COG1561	YicC-like family, N-terminal region
VFU_RS00900	COG2003	Belongs to the UPF0758 family
VFU_RS00950	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VFU_RS00975	COG2963	transposase activity
VFU_RS00980	COG5002	protein histidine kinase activity
VFU_RS00995	COG3335	DDE superfamily endonuclease
VFU_RS01020	COG2217	Heavy metal translocating P-type atpase
VFU_RS01025	COG0789	Transcriptional regulator
VFU_RS01080	COG0328	RNA-DNA hybrid ribonuclease activity
VFU_RS01110	COG2862	Uncharacterized protein family, UPF0114
VFU_RS01120	COG4607	ABC-type enterochelin transport system periplasmic component
VFU_RS01125	COG1120	ATPase activity
VFU_RS01130	COG4774	siderophore transport
VFU_RS01135	COG1132	(ABC) transporter
VFU_RS01150	COG0514	ATP-dependent DNA helicase (RecQ)
VFU_RS01155	COG2962	Rard protein
VFU_RS01165	COG1280	lysine exporter protein (LysE YggA)
VFU_RS01170	COG0405	Gamma-glutamyltransferase
VFU_RS01175	COG0210	DNA helicase
VFU_RS01210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VFU_RS01215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VFU_RS01230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VFU_RS01235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VFU_RS01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VFU_RS01275	COG0601	transmembrane transport
VFU_RS01280	COG0747	negative chemotaxis
VFU_RS01330	COG1309	transcriptional regulator
VFU_RS01335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VFU_RS01340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VFU_RS01345	COG2960	long-chain fatty acid transporting porin activity
VFU_RS01355	COG0583	DNA-binding transcription factor activity
VFU_RS01395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VFU_RS01405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VFU_RS01410	COG0408	coproporphyrinogen oxidase activity
VFU_RS01420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VFU_RS01425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VFU_RS01430	COG0551	DNA topoisomerase type I activity
VFU_RS01435	COG2922	Belongs to the Smg family
VFU_RS01440	COG0758	DNA mediated transformation
VFU_RS01460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VFU_RS01460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VFU_RS01465	COG0569	domain protein
VFU_RS01470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VFU_RS01480	COG1272	protein, Hemolysin III
VFU_RS01485	COG4326	sporulation control protein
VFU_RS01490	COG3084	Protein conserved in bacteria
VFU_RS01500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VFU_RS01505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VFU_RS01510	COG0204	Acyl-transferase
VFU_RS01515	COG0606	chelatase, subunit chli
VFU_RS01525	COG3978	acetolactate synthase activity
VFU_RS01530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VFU_RS01545	COG0604	alcohol dehydrogenase
VFU_RS01570	COG0425	Belongs to the sulfur carrier protein TusA family
VFU_RS01580	COG2119	membrane
VFU_RS01585	COG0752	glycyl-tRNA synthetase alpha subunit
VFU_RS01590	COG0751	glycine-tRNA ligase activity
VFU_RS01595	COG3977	Valine--pyruvate aminotransferase
VFU_RS01600	COG0071	Belongs to the small heat shock protein (HSP20) family
VFU_RS01610	COG0187	DNA topoisomerase II activity
VFU_RS01620	COG0592	DNA-directed DNA polymerase activity
VFU_RS01625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VFU_RS01640	COG1126	abc transporter atp-binding protein
VFU_RS01650	COG0706	membrane insertase activity
VFU_RS01675	COG4869	propanediol catabolic process
VFU_RS01685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VFU_RS01690	COG1882	Formate acetyltransferase
VFU_RS01705	COG1012	belongs to the aldehyde dehydrogenase family
VFU_RS01705	COG1454	alcohol dehydrogenase
VFU_RS01740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VFU_RS01745	COG0445	tRNA wobble uridine modification
VFU_RS01750	COG0357	Ribosomal RNA small subunit methyltransferase G
VFU_RS01755	COG1192	Involved in chromosome partitioning
VFU_RS01760	COG1475	DNA binding
VFU_RS01765	COG3312	ion transport
VFU_RS01780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VFU_RS01785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VFU_RS01790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VFU_RS01795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VFU_RS01800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VFU_RS01805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VFU_RS01815	COG0765	amino acid transport
VFU_RS01825	COG2814	Major facilitator Superfamily
VFU_RS01830	COG0583	DNA-binding transcription factor activity
VFU_RS01835	COG0183	Belongs to the thiolase family
VFU_RS01845	COG1739	Uncharacterized protein family UPF0029
VFU_RS01850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VFU_RS01905	COG2132	Multicopper oxidase
VFU_RS01910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VFU_RS01915	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VFU_RS01925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VFU_RS01935	COG2022	thiamine diphosphate biosynthetic process
VFU_RS01940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VFU_RS01945	COG4175	Glycine betaine
VFU_RS01960	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
VFU_RS01970	COG1309	transcriptional regulator
VFU_RS01975	COG0006	proline dipeptidase activity
VFU_RS01975	COG0006	proline dipeptidase activity
VFU_RS01995	COG1522	sequence-specific DNA binding
VFU_RS02000	COG5001	Diguanylate cyclase
VFU_RS02000	COG5002	protein histidine kinase activity
VFU_RS02020	COG0589	response to stress
VFU_RS02025	COG1528	Iron-storage protein
VFU_RS02035	COG2081	HI0933 family
VFU_RS02040	COG1172	Belongs to the binding-protein-dependent transport system permease family
VFU_RS02045	COG1172	Belongs to the binding-protein-dependent transport system permease family
VFU_RS02050	COG1129	ABC transporter
VFU_RS02055	COG1879	ABC-type sugar transport system periplasmic component
VFU_RS02065	COG1129	ABC transporter
VFU_RS02070	COG1879	ABC-type sugar transport system periplasmic component
VFU_RS02075	COG1069	ribulokinase activity
VFU_RS02085	COG2160	L-arabinose isomerase activity
VFU_RS02110	COG1322	Protein conserved in bacteria
VFU_RS02120	COG3165	ubiquinone biosynthetic process from chorismate
VFU_RS02130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VFU_RS02135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VFU_RS02140	COG0805	protein transport
VFU_RS02145	COG0084	hydrolase, TatD family'
VFU_RS02160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VFU_RS02160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VFU_RS02190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VFU_RS02195	COG3071	HemY protein
VFU_RS02200	COG2959	enzyme of heme biosynthesis
VFU_RS02215	COG3072	Adenylate cyclase
VFU_RS02220	COG1965	Belongs to the frataxin family
VFU_RS02230	COG0019	diaminopimelate decarboxylase activity
VFU_RS02235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VFU_RS02245	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VFU_RS02250	COG1011	Hydrolase
VFU_RS02255	COG3287	FIST C domain
VFU_RS02255	COG2199	diguanylate cyclase activity
VFU_RS02255	COG2200	EAL domain
VFU_RS02260	COG3148	PFAM DTW domain containing protein
VFU_RS02270	COG0561	phosphatase activity
VFU_RS02275	COG2267	carboxylic ester hydrolase activity
VFU_RS02280	COG1280	lysine exporter protein (LysE YggA)
VFU_RS02285	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VFU_RS02290	COG0640	Transcriptional regulator
VFU_RS02295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VFU_RS02310	COG0783	Belongs to the Dps family
VFU_RS02340	COG2095	MarC family integral membrane protein
VFU_RS02350	COG0742	ribosomal rna small subunit methyltransferase
VFU_RS02355	COG0552	protein localization to endoplasmic reticulum
VFU_RS02360	COG2884	Cell division ATP-binding protein ftsE
VFU_RS02365	COG2177	Part of the ABC transporter FtsEX involved in
VFU_RS02370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VFU_RS02375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VFU_RS02380	COG0705	Rhomboid family
VFU_RS02385	COG1580	Controls the rotational direction of flagella during chemotaxis
VFU_RS02390	COG3161	chorismate lyase activity
VFU_RS02395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VFU_RS02400	COG2937	Belongs to the GPAT DAPAT family
VFU_RS02405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VFU_RS02410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VFU_RS02420	COG0534	Mate efflux family protein
VFU_RS02425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VFU_RS02440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VFU_RS02455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VFU_RS02490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VFU_RS02495	COG5001	Diguanylate cyclase
VFU_RS02495	COG3300	MHYT domain
VFU_RS02500	COG2204	response regulator
VFU_RS02505	COG3852	Histidine kinase
VFU_RS02515	COG0174	glutamine synthetase
VFU_RS02520	COG1217	gtp-binding protein TYPA
VFU_RS02540	COG1490	D-aminoacyl-tRNA deacylase activity
VFU_RS02545	COG0456	acetyltransferase
VFU_RS02550	COG2982	Protein involved in outer membrane biogenesis
VFU_RS02555	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VFU_RS02565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VFU_RS02570	COG3031	protein transport across the cell outer membrane
VFU_RS02585	COG1459	type II secretion system
VFU_RS02590	COG2165	general secretion pathway protein
VFU_RS02595	COG2165	general secretion pathway protein
VFU_RS02600	COG2165	general secretion pathway protein
VFU_RS02605	COG4795	General secretion pathway protein
VFU_RS02610	COG3156	type II secretion system protein K
VFU_RS02615	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VFU_RS02620	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VFU_RS02630	COG1218	3'(2'),5'-bisphosphate nucleotidase
VFU_RS02635	COG0494	nUDIX hydrolase
VFU_RS02645	COG1040	competence protein
VFU_RS02650	COG0596	Alpha beta hydrolase
VFU_RS02670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VFU_RS02675	COG1609	Transcriptional regulator
VFU_RS02680	COG0129	dihydroxy-acid dehydratase activity
VFU_RS02685	COG3265	gluconokinase activity
VFU_RS02690	COG2610	gluconate transmembrane transporter activity
VFU_RS02695	COG0800	Aldolase
VFU_RS02710	COG2233	PERMEase
VFU_RS02715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VFU_RS02720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VFU_RS02725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VFU_RS02730	COG1758	RNA polymerase activity
VFU_RS02735	COG0194	GDP metabolic process
VFU_RS02740	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VFU_RS02745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VFU_RS02770	COG4232	protein-disulfide reductase activity
VFU_RS02780	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VFU_RS02785	COG0540	Belongs to the ATCase OTCase family
VFU_RS02790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VFU_RS02805	COG1288	antiporter activity
VFU_RS02810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VFU_RS02815	COG1027	Aspartate ammonia-lyase
VFU_RS02830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VFU_RS02835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VFU_RS02840	COG2205	protein histidine kinase activity
VFU_RS02845	COG0745	RESPONSE REGULATOR receiver
VFU_RS02855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VFU_RS02860	COG0205	6-phosphofructokinase activity
VFU_RS02865	COG1494	fructose-1,6-bisphosphatase
VFU_RS02870	COG3074	FtsZ-dependent cytokinesis
VFU_RS02875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VFU_RS02880	COG0460	homoserine dehydrogenase
VFU_RS02880	COG0527	aspartate kinase activity
VFU_RS02885	COG0626	cystathionine gamma-synthase activity
VFU_RS02890	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VFU_RS02895	COG0281	malic enzyme
VFU_RS02905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VFU_RS02910	COG1609	Transcriptional regulator
VFU_RS02920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VFU_RS02930	COG1575	Belongs to the MenA family. Type 1 subfamily
VFU_RS02935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VFU_RS02940	COG0534	Mate efflux family protein
VFU_RS02945	COG0149	triose-phosphate isomerase activity
VFU_RS02975	COG0459	protein refolding
VFU_RS02980	COG1119	ATPase activity
VFU_RS02990	COG1285	pathogenesis
VFU_RS02995	COG1509	lysine 2,3-aminomutase activity
VFU_RS03000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VFU_RS03010	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VFU_RS03015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VFU_RS03020	COG1053	succinate dehydrogenase
VFU_RS03025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VFU_RS03030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VFU_RS03035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VFU_RS03045	COG1045	serine acetyltransferase
VFU_RS03055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VFU_RS03060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VFU_RS03065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VFU_RS03070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VFU_RS03075	COG0137	argininosuccinate synthase activity
VFU_RS03090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VFU_RS03090	COG0678	peroxiredoxin activity
VFU_RS03100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VFU_RS03135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VFU_RS03145	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VFU_RS03150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VFU_RS03160	COG0180	Tryptophanyl-tRNA synthetase
VFU_RS03180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VFU_RS03190	COG1012	belongs to the aldehyde dehydrogenase family
VFU_RS03205	COG3954	Phosphoribulokinase
VFU_RS03215	COG0429	hydrolase of the alpha beta-hydrolase fold
VFU_RS03225	COG0488	(ABC) transporter
VFU_RS03230	COG2249	NAD(P)H dehydrogenase (quinone) activity
VFU_RS03240	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VFU_RS03245	COG1047	Peptidyl-prolyl cis-trans
VFU_RS03255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VFU_RS03260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VFU_RS03265	COG3083	sulfuric ester hydrolase activity
VFU_RS03275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VFU_RS03280	COG0051	transcription antitermination factor activity, RNA binding
VFU_RS03285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VFU_RS03290	COG0088	Forms part of the polypeptide exit tunnel
VFU_RS03295	COG0089	rRNA binding
VFU_RS03300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VFU_RS03305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VFU_RS03310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VFU_RS03315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VFU_RS03325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VFU_RS03330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VFU_RS03335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VFU_RS03340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VFU_RS03345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VFU_RS03350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VFU_RS03360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VFU_RS03370	COG1841	ribosomal large subunit assembly
VFU_RS03375	COG0200	Binds to the 23S rRNA
VFU_RS03380	COG0201	protein transport
VFU_RS03385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VFU_RS03390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VFU_RS03395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VFU_RS03400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VFU_RS03405	COG0202	RNA polymerase activity
VFU_RS03420	COG0545	Peptidyl-prolyl cis-trans isomerase
VFU_RS03425	COG3061	Opacity-associated protein A
VFU_RS03435	COG2153	protein acetylation
VFU_RS03440	COG0513	Belongs to the DEAD box helicase family
VFU_RS03450	COG0737	Belongs to the 5'-nucleotidase family
VFU_RS03455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VFU_RS03455	COG1648	precorrin-2 dehydrogenase activity
VFU_RS03465	COG2895	sulfate adenylyltransferase (ATP) activity
VFU_RS03470	COG0471	metal ion transport
VFU_RS03470	COG3273	potassium ion transport
VFU_RS03475	COG0529	Catalyzes the synthesis of activated sulfate
VFU_RS03500	COG0577	efflux transmembrane transporter activity
VFU_RS03500	COG1136	(ABC) transporter
VFU_RS03515	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VFU_RS03520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VFU_RS03525	COG0729	surface antigen
VFU_RS03535	COG2105	PFAM AIG2 family protein
VFU_RS03545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VFU_RS03550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VFU_RS03555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VFU_RS03560	COG0163	prenyltransferase activity
VFU_RS03570	COG1178	ABC-type Fe3 transport system permease component
VFU_RS03575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VFU_RS03580	COG3028	Belongs to the UPF0307 family
VFU_RS03585	COG0312	modulator of DNA gyrase
VFU_RS03590	COG2239	Acts as a magnesium transporter
VFU_RS03595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VFU_RS03600	COG1660	Displays ATPase and GTPase activities
VFU_RS03605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VFU_RS03610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VFU_RS03620	COG1137	ATPase activity
VFU_RS03625	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VFU_RS03635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VFU_RS03640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VFU_RS03640	COG0517	IMP dehydrogenase activity
VFU_RS03650	COG1127	ABC transporter
VFU_RS03655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VFU_RS03660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VFU_RS03665	COG2854	intermembrane phospholipid transfer
VFU_RS03670	COG3113	response to antibiotic
VFU_RS03675	COG5007	Belongs to the BolA IbaG family
VFU_RS03685	COG0204	Acyl-transferase
VFU_RS03690	COG0251	oxidation-reduction process
VFU_RS03695	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VFU_RS03700	COG0540	Belongs to the ATCase OTCase family
VFU_RS03705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VFU_RS03710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VFU_RS03725	COG0564	pseudouridine synthase activity
VFU_RS03730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VFU_RS03745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VFU_RS03750	COG0795	lipopolysaccharide-transporting ATPase activity
VFU_RS03755	COG0795	lipopolysaccharide-transporting ATPase activity
VFU_RS03765	COG3706	GGDEF domain
VFU_RS03830	COG2916	Histone family protein nucleoid-structuring protein H-NS
VFU_RS03870	COG0583	DNA-binding transcription factor activity
VFU_RS03880	COG0840	transmembrane signaling receptor activity
VFU_RS03910	COG3437	response regulator, receiver
VFU_RS03955	COG0066	3-isopropylmalate dehydratase activity
VFU_RS03960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VFU_RS03965	COG0473	3-isopropylmalate dehydrogenase activity
VFU_RS03990	COG0583	DNA-binding transcription factor activity
VFU_RS03995	COG1022	Amp-dependent synthetase and ligase
VFU_RS04000	COG0028	Belongs to the TPP enzyme family
VFU_RS04005	COG0440	acetolactate synthase activity
VFU_RS04010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VFU_RS04015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VFU_RS04020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VFU_RS04025	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VFU_RS04030	COG3079	Belongs to the UPF0149 family
VFU_RS04035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VFU_RS04040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VFU_RS04060	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VFU_RS04070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VFU_RS04075	COG1595	DNA-templated transcription, initiation
VFU_RS04090	COG3086	response to oxidative stress
VFU_RS04095	COG0481	GTPase activity
VFU_RS04110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VFU_RS04115	COG1381	Involved in DNA repair and RecF pathway recombination
VFU_RS04120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VFU_RS04135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VFU_RS04140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VFU_RS04145	COG3956	TIGRFAM MazG family protein
VFU_RS04150	COG0504	CTP synthase activity
VFU_RS04155	COG0148	phosphopyruvate hydratase activity
VFU_RS04160	COG0617	tRNA 3'-terminal CCA addition
VFU_RS04165	COG3409	Peptidoglycan-binding domain 1 protein
VFU_RS04165	COG3267	Type II secretory pathway component ExeA
VFU_RS04175	COG4991	sh3 domain protein
VFU_RS04180	COG0306	phosphate transporter
VFU_RS04185	COG1392	Phosphate transport regulator
VFU_RS04190	COG3025	triphosphatase activity
VFU_RS04195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VFU_RS04210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VFU_RS04210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VFU_RS04215	COG1538	Outer membrane efflux protein
VFU_RS04220	COG0494	nUDIX hydrolase
VFU_RS04225	COG3151	Protein conserved in bacteria
VFU_RS04235	COG3150	esterase
VFU_RS04255	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VFU_RS04260	COG0237	dephospho-CoA kinase activity
VFU_RS04270	COG1459	type II secretion system
VFU_RS04275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VFU_RS04300	COG4974	Belongs to the 'phage' integrase family
VFU_RS04305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VFU_RS04310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VFU_RS04315	COG2186	Transcriptional regulator
VFU_RS04320	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VFU_RS04325	COG0508	dehydrogenase complex catalyzes the overall conversion of
VFU_RS04330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VFU_RS04345	COG0288	reversible hydration of carbon dioxide
VFU_RS04350	COG1131	(ABC) transporter
VFU_RS04355	COG0842	Transport permease protein
VFU_RS04360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VFU_RS04365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VFU_RS04370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VFU_RS04380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VFU_RS04385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VFU_RS04390	COG1489	DNA binding
VFU_RS04395	COG1643	Atp-dependent helicase
VFU_RS04400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VFU_RS04405	COG1752	Esterase of the alpha-beta hydrolase superfamily
VFU_RS04410	COG1049	propionate catabolic process, 2-methylcitrate cycle
VFU_RS04415	COG3112	Uncharacterised protein family (UPF0231)
VFU_RS04420	COG0347	Belongs to the P(II) protein family
VFU_RS04425	COG0004	ammonium transporteR
VFU_RS04430	COG1840	ABC-type Fe3 transport system, periplasmic component
VFU_RS04440	COG3842	ATPase activity
VFU_RS04445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VFU_RS04460	COG2971	BadF BadG BcrA BcrD
VFU_RS04470	COG4608	Belongs to the ABC transporter superfamily
VFU_RS04475	COG0444	Belongs to the ABC transporter superfamily
VFU_RS04480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VFU_RS04490	COG0747	negative chemotaxis
VFU_RS04495	COG2205	protein histidine kinase activity
VFU_RS04495	COG0784	Response regulator, receiver
VFU_RS04500	COG2813	Specifically methylates the guanine in position
VFU_RS04505	COG0628	permease
VFU_RS04510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VFU_RS04515	COG0316	Belongs to the HesB IscA family
VFU_RS04530	COG0739	heme binding
VFU_RS04535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VFU_RS04545	COG2239	Acts as a magnesium transporter
VFU_RS04550	COG2027	D-alanyl-D-alanine carboxypeptidase
VFU_RS04555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VFU_RS04560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VFU_RS04565	COG1534	Rna-binding protein
VFU_RS04570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VFU_RS04580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VFU_RS04585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VFU_RS04590	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VFU_RS04610	COG0779	Required for maturation of 30S ribosomal subunits
VFU_RS04615	COG0195	Participates in both transcription termination and antitermination
VFU_RS04620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VFU_RS04625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VFU_RS04655	COG0534	Mate efflux family protein
VFU_RS04660	COG0826	peptidase U32
VFU_RS04665	COG0826	peptidase U32
VFU_RS04675	COG3154	lipid carrier protein
VFU_RS04680	COG3153	acetyltransferase
VFU_RS04705	COG0513	Belongs to the DEAD box helicase family
VFU_RS04710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VFU_RS04720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VFU_RS04725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VFU_RS04730	COG2204	response regulator
VFU_RS04740	COG0667	Aldo Keto reductase
VFU_RS04755	COG0494	nUDIX hydrolase
VFU_RS04765	COG0730	response to heat
VFU_RS04775	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VFU_RS04780	COG1283	sodium-dependent phosphate transmembrane transporter activity
VFU_RS04785	COG0583	DNA-binding transcription factor activity
VFU_RS04790	COG0640	Transcriptional regulator
VFU_RS04795	COG0268	Binds directly to 16S ribosomal RNA
VFU_RS04800	COG0728	peptidoglycan biosynthetic process
VFU_RS04805	COG0196	riboflavin kinase activity
VFU_RS04810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VFU_RS04815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VFU_RS04820	COG1047	Peptidyl-prolyl cis-trans
VFU_RS04825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VFU_RS04830	COG1966	Carbon starvation protein
VFU_RS04845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VFU_RS04850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VFU_RS04860	COG3279	Response regulator of the LytR AlgR family
VFU_RS04865	COG3275	phosphorelay sensor kinase activity
VFU_RS04870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VFU_RS04875	COG1605	Chorismate mutase
VFU_RS04875	COG0287	Prephenate dehydrogenase
VFU_RS04895	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VFU_RS04900	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VFU_RS04905	COG5001	Diguanylate cyclase
VFU_RS04910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VFU_RS04915	COG0077	Prephenate dehydratase
VFU_RS04915	COG1605	Chorismate mutase
VFU_RS04920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VFU_RS04925	COG0741	lytic transglycosylase activity
VFU_RS04930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VFU_RS04935	COG0564	pseudouridine synthase activity
VFU_RS04945	COG0542	response to heat
VFU_RS04955	COG0590	tRNA wobble adenosine to inosine editing
VFU_RS04960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VFU_RS04970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VFU_RS05030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VFU_RS05045	COG0271	Belongs to the BolA IbaG family
VFU_RS05050	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VFU_RS05055	COG1805	sodium ion transport
VFU_RS05065	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VFU_RS05070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VFU_RS05075	COG2871	sodium ion transport
VFU_RS05080	COG1477	protein flavinylation
VFU_RS05095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VFU_RS05105	COG4251	negative regulation of phosphorylation
VFU_RS05105	COG5001	Diguanylate cyclase
VFU_RS05105	COG2203	Gaf domain
VFU_RS05105	COG3706	GGDEF domain
VFU_RS05110	COG0733	neurotransmitter:sodium symporter activity
VFU_RS05120	COG0189	ligase activity
VFU_RS05125	COG0189	ligase activity
VFU_RS05125	COG4067	protein conserved in archaea
VFU_RS05130	COG2195	Cleaves the N-terminal amino acid of tripeptides
VFU_RS05135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VFU_RS05140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VFU_RS05150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VFU_RS05160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VFU_RS05165	COG2252	PERMEase
VFU_RS05170	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VFU_RS05175	COG1073	alpha beta
VFU_RS05190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VFU_RS05195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VFU_RS05200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VFU_RS05200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VFU_RS05215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VFU_RS05220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VFU_RS05225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VFU_RS05230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VFU_RS05240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VFU_RS05245	COG0024	Methionine aminopeptidase
VFU_RS05250	COG0052	Belongs to the universal ribosomal protein uS2 family
VFU_RS05255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VFU_RS05265	COG0233	cytoplasmic translational termination
VFU_RS05270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VFU_RS05275	COG0575	Belongs to the CDS family
VFU_RS05280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VFU_RS05285	COG0750	zinc metalloprotease
VFU_RS05295	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VFU_RS05300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VFU_RS05305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VFU_RS05320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VFU_RS05325	COG0587	DNA-directed DNA polymerase activity
VFU_RS05330	COG0825	malonyl-CoA metabolic process
VFU_RS05335	COG0037	tRNA processing
VFU_RS05345	COG0347	Belongs to the P(II) protein family
VFU_RS05350	COG3021	interspecies interaction between organisms
VFU_RS05360	COG1388	LysM domain
VFU_RS05360	COG0741	lytic transglycosylase activity
VFU_RS05365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VFU_RS05370	COG2226	methyltransferase
VFU_RS05375	COG0328	RNA-DNA hybrid ribonuclease activity
VFU_RS05380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VFU_RS05390	COG1960	acyl-CoA dehydrogenase activity
VFU_RS05395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VFU_RS05400	COG0121	glutamine amidotransferase
VFU_RS05405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VFU_RS05410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VFU_RS05415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VFU_RS05420	COG1187	pseudouridine synthase activity
VFU_RS05425	COG2840	Smr protein MutS2
VFU_RS05455	COG2217	Heavy metal translocating P-type atpase
VFU_RS05455	COG2608	mercury ion transmembrane transporter activity
VFU_RS05460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VFU_RS05500	COG2747	anti-sigma28 factor FlgM
VFU_RS05510	COG0835	chemotaxis
VFU_RS05510	COG0784	Response regulator, receiver
VFU_RS05515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VFU_RS05520	COG1815	bacterial-type flagellum-dependent cell motility
VFU_RS05540	COG4787	bacterial-type flagellum-dependent cell motility
VFU_RS05550	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VFU_RS05555	COG1706	bacterial-type flagellum-dependent cell motility
VFU_RS05560	COG3951	Flagellar rod assembly protein muramidase FlgJ
VFU_RS05560	COG1705	Flagellar rod assembly protein muramidase FlgJ
VFU_RS05570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VFU_RS05575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VFU_RS05680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VFU_RS05685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VFU_RS05690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VFU_RS05695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VFU_RS05700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VFU_RS05705	COG2890	protein-(glutamine-N5) methyltransferase activity
VFU_RS05715	COG2912	Transglutaminase-like superfamily
VFU_RS05720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VFU_RS05725	COG0737	Belongs to the 5'-nucleotidase family
VFU_RS05730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VFU_RS05735	COG2233	PERMEase
VFU_RS05755	COG1393	Belongs to the ArsC family
VFU_RS05760	COG4783	chaperone-mediated protein folding
VFU_RS05780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VFU_RS05785	COG2716	regulation of RNA biosynthetic process
VFU_RS05795	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VFU_RS05805	COG1876	peptidase activity
VFU_RS05815	COG1393	Belongs to the ArsC family
VFU_RS05825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VFU_RS05830	COG1085	galactose-1-phosphate uridylyltransferase
VFU_RS05835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VFU_RS05850	COG0517	IMP dehydrogenase activity
VFU_RS05850	COG0516	GMP reductase activity
VFU_RS05870	COG2837	iron assimilation
VFU_RS05885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VFU_RS05890	COG1334	flagellar protein FlaG
VFU_RS05895	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VFU_RS05905	COG1516	flagellar protein fliS
VFU_RS05925	COG1677	Flagellar hook-basal body complex protein FliE
VFU_RS05935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VFU_RS05985	COG1987	bacterial-type flagellum assembly
VFU_RS06000	COG2840	Smr protein MutS2
VFU_RS06005	COG2890	protein-(glutamine-N5) methyltransferase activity
VFU_RS06010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VFU_RS06015	COG2860	membrane
VFU_RS06020	COG3101	peptidyl-lysine hydroxylation
VFU_RS06035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VFU_RS06035	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VFU_RS06040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VFU_RS06045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VFU_RS06050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VFU_RS06055	COG0735	belongs to the Fur family
VFU_RS06065	COG0583	DNA-binding transcription factor activity
VFU_RS06070	COG1380	Effector of murein hydrolase LrgA
VFU_RS06075	COG1346	cytolysis
VFU_RS06090	COG0596	Alpha beta hydrolase
VFU_RS06095	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VFU_RS06100	COG0033	Phosphoglucomutase
VFU_RS06110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VFU_RS06125	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VFU_RS06130	COG1053	succinate dehydrogenase
VFU_RS06140	COG0567	Dehydrogenase, E1 component
VFU_RS06145	COG0508	dehydrogenase complex catalyzes the overall conversion of
VFU_RS06160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VFU_RS06165	COG1121	(ABC) transporter
VFU_RS06170	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VFU_RS06175	COG2207	Transcriptional regulator
VFU_RS06180	COG1918	ferrous iron import across plasma membrane
VFU_RS06205	COG3102	Protein conserved in bacteria
VFU_RS06215	COG2062	phosphohistidine phosphatase, SixA
VFU_RS06245	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VFU_RS06250	COG0784	Response regulator, receiver
VFU_RS06250	COG0643	Histidine kinase
VFU_RS06250	COG2198	Histidine kinase
VFU_RS06255	COG2201	protein-glutamate methylesterase activity
VFU_RS06260	COG1192	Involved in chromosome partitioning
VFU_RS06270	COG0835	chemotaxis
VFU_RS06280	COG4133	protoheme IX ABC transporter activity
VFU_RS06285	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VFU_RS06290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VFU_RS06295	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VFU_RS06300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VFU_RS06305	COG1138	Cytochrome C-type biogenesis protein
VFU_RS06310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VFU_RS06325	COG2853	Lipoprotein
VFU_RS06345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VFU_RS06350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VFU_RS06365	COG0123	including yeast histone deacetylase and acetoin utilization protein
VFU_RS06375	COG1448	Aminotransferase
VFU_RS06395	COG2814	Major facilitator Superfamily
VFU_RS06410	COG3083	sulfuric ester hydrolase activity
VFU_RS06415	COG3082	Protein of unknown function (DUF1414)
VFU_RS06420	COG3081	Nucleoid-associated protein
VFU_RS06430	COG1757	Na H antiporter
VFU_RS06435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VFU_RS06440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VFU_RS06445	COG2095	MarC family integral membrane protein
VFU_RS06450	COG1012	belongs to the aldehyde dehydrogenase family
VFU_RS06450	COG1454	alcohol dehydrogenase
VFU_RS06460	COG0659	secondary active sulfate transmembrane transporter activity
VFU_RS06470	COG1530	ribonuclease E activity
VFU_RS06475	COG0564	pseudouridine synthase activity
VFU_RS06480	COG0424	maF-like protein
VFU_RS06485	COG1399	metal-binding, possibly nucleic acid-binding protein
VFU_RS06490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VFU_RS06495	COG0416	fatty acid biosynthetic process
VFU_RS06500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VFU_RS06520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VFU_RS06525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VFU_RS06530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VFU_RS06535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VFU_RS06540	COG0470	DNA polymerase III
VFU_RS06545	COG0084	hydrolase, TatD family'
VFU_RS06550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VFU_RS06550	COG2190	(PTS) system
VFU_RS06550	COG1263	PTS System
VFU_RS06560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VFU_RS06560	COG1263	PTS System
VFU_RS06570	COG0733	neurotransmitter:sodium symporter activity
VFU_RS06585	COG4667	esterase of the alpha-beta hydrolase superfamily
VFU_RS06590	COG0469	pyruvate kinase activity
VFU_RS06595	COG1940	carbohydrate kinase activity
VFU_RS06600	COG0835	chemotaxis
VFU_RS06600	COG0784	Response regulator, receiver
VFU_RS06605	COG0587	DNA-directed DNA polymerase activity
VFU_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
VFU_RS06625	COG0616	signal peptide processing
VFU_RS06645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VFU_RS06650	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VFU_RS06655	COG0436	Aminotransferase
VFU_RS06665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VFU_RS06695	COG2855	membrane
VFU_RS06700	COG0477	Major facilitator Superfamily
VFU_RS06720	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
VFU_RS06725	COG1388	LysM domain
VFU_RS06725	COG0741	lytic transglycosylase activity
VFU_RS06745	COG1815	bacterial-type flagellum-dependent cell motility
VFU_RS06750	COG1558	bacterial-type flagellum-dependent cell motility
VFU_RS06755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VFU_RS06760	COG1749	Flagellar hook protein flgE
VFU_RS06770	COG4786	Flagellar basal body rod
VFU_RS06775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VFU_RS06780	COG1706	bacterial-type flagellum-dependent cell motility
VFU_RS06790	COG4786	Flagellar basal body rod
VFU_RS06790	COG1256	bacterial-type flagellum assembly
VFU_RS06830	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
VFU_RS06880	COG3015	lipoprotein NlpE involved in copper resistance
VFU_RS06890	COG1360	Flagellar Motor Protein
VFU_RS06895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VFU_RS06900	COG1191	sigma factor activity
VFU_RS06905	COG1580	Controls the rotational direction of flagella during chemotaxis
VFU_RS06925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VFU_RS06930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VFU_RS06945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VFU_RS06975	COG3047	cAMP biosynthetic process
VFU_RS06975	COG2885	chlorophyll binding
VFU_RS07020	COG1522	sequence-specific DNA binding
VFU_RS07025	COG1946	Acyl-CoA thioesterase
VFU_RS07030	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VFU_RS07045	COG5001	Diguanylate cyclase
VFU_RS07045	COG5002	protein histidine kinase activity
VFU_RS07050	COG2814	Major facilitator Superfamily
VFU_RS07060	COG4773	Receptor
VFU_RS07065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VFU_RS07075	COG2382	esterase
VFU_RS07090	COG1881	PFAM PEBP family protein
VFU_RS07095	COG2207	Transcriptional regulator
VFU_RS07115	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VFU_RS07120	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VFU_RS07140	COG0513	Belongs to the DEAD box helicase family
VFU_RS07145	COG1368	sulfuric ester hydrolase activity
VFU_RS07150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VFU_RS07155	COG2194	sulfuric ester hydrolase activity
VFU_RS07160	COG4566	intracellular signal transduction
VFU_RS07195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VFU_RS07200	COG1271	oxidase subunit
VFU_RS07205	COG1294	oxidase, subunit
VFU_RS07240	COG2249	NAD(P)H dehydrogenase (quinone) activity
VFU_RS07255	COG1021	2,3-dihydroxybenzoate-AMP ligase
VFU_RS07260	COG1169	isochorismate synthase
VFU_RS07265	COG1028	Short-chain dehydrogenase reductase Sdr
VFU_RS07270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VFU_RS07275	COG2226	methyltransferase
VFU_RS07275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VFU_RS07275	COG3433	isochorismatase activity
VFU_RS07290	COG4592	Periplasmic binding protein
VFU_RS07295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VFU_RS07300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VFU_RS07305	COG1629	transport
VFU_RS07305	COG4774	siderophore transport
VFU_RS07315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VFU_RS07320	COG1120	ATPase activity
VFU_RS07330	COG1609	Transcriptional regulator
VFU_RS07335	COG2723	6-phospho-beta-galactosidase activity
VFU_RS07340	COG1741	Belongs to the pirin family
VFU_RS07345	COG0352	thiamine-phosphate diphosphorylase activity
VFU_RS07355	COG0351	phosphomethylpyrimidine kinase
VFU_RS07365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VFU_RS07370	COG0601	transmembrane transport
VFU_RS07375	COG0747	negative chemotaxis
VFU_RS07385	COG1538	Outer membrane efflux protein
VFU_RS07390	COG1566	PFAM secretion protein HlyD family protein
VFU_RS07395	COG2814	Major facilitator Superfamily
VFU_RS07400	COG3708	Transcriptional regulator
VFU_RS07400	COG2207	Transcriptional regulator
VFU_RS07410	COG0745	RESPONSE REGULATOR receiver
VFU_RS07420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VFU_RS07420	COG1263	PTS System
VFU_RS07435	COG1621	beta-fructofuranosidase activity
VFU_RS07445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VFU_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
VFU_RS07470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VFU_RS07495	COG2986	histidine ammonia-lyase
VFU_RS07500	COG1216	Glycosyl transferase, family 2
VFU_RS07520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VFU_RS07525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VFU_RS07530	COG0318	PFAM AMP-dependent synthetase and ligase
VFU_RS07530	COG0204	Acyl-transferase
VFU_RS07560	COG0601	transmembrane transport
VFU_RS07565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VFU_RS07570	COG0444	Belongs to the ABC transporter superfamily
VFU_RS07585	COG0435	Glutathione S-transferase
VFU_RS07590	COG3174	membrane
VFU_RS07595	COG0280	phosphate acetyltransferase
VFU_RS07595	COG0857	belongs to the CobB CobQ family
VFU_RS07600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VFU_RS07605	COG3092	negative regulation of chromosome organization
VFU_RS07615	COG4120	Belongs to the binding-protein-dependent transport system permease family
VFU_RS07625	COG3706	GGDEF domain
VFU_RS07635	COG2165	general secretion pathway protein
VFU_RS07640	COG0653	protein targeting
VFU_RS07645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VFU_RS07650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VFU_RS07655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VFU_RS07665	COG0243	molybdopterin cofactor binding
VFU_RS07670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VFU_RS07670	COG1648	precorrin-2 dehydrogenase activity
VFU_RS07685	COG1116	anion transmembrane transporter activity
VFU_RS07685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VFU_RS07690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VFU_RS07695	COG1116	anion transmembrane transporter activity
VFU_RS07700	COG2146	nitrite reductase [NAD(P)H] activity
VFU_RS07700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VFU_RS07710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VFU_RS07720	COG0156	8-amino-7-oxononanoate synthase activity
VFU_RS07725	COG2226	methyltransferase
VFU_RS07730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VFU_RS07735	COG0501	Belongs to the peptidase M48B family
VFU_RS07745	COG1028	Short-chain dehydrogenase reductase Sdr
VFU_RS07760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VFU_RS07780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VFU_RS07785	COG2915	High frequency lysogenization protein hflD homolog
VFU_RS07790	COG0482	sulfurtransferase activity
VFU_RS07795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VFU_RS07800	COG2916	Histone family protein nucleoid-structuring protein H-NS
VFU_RS07805	COG1757	Na H antiporter
VFU_RS07815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VFU_RS07820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VFU_RS07825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VFU_RS07830	COG0131	Imidazoleglycerol-phosphate dehydratase
VFU_RS07830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VFU_RS07835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VFU_RS07840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VFU_RS07850	COG0140	phosphoribosyl-ATP diphosphatase activity
VFU_RS07850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VFU_RS07855	COG1187	pseudouridine synthase activity
VFU_RS07865	COG1695	Transcriptional regulator
VFU_RS07870	COG2223	nitrite transmembrane transporter activity
VFU_RS07880	COG1278	Cold shock
VFU_RS07885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VFU_RS07890	COG0542	response to heat
VFU_RS07895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VFU_RS07900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VFU_RS07905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VFU_RS07925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VFU_RS07935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VFU_RS07940	COG0297	glycogen (starch) synthase activity
VFU_RS07960	COG3070	regulator of competence-specific genes
VFU_RS07965	COG1609	Transcriptional regulator
VFU_RS07970	COG3381	protein complex oligomerization
VFU_RS07975	COG0745	RESPONSE REGULATOR receiver
VFU_RS07980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VFU_RS07985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VFU_RS07990	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VFU_RS07995	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VFU_RS08015	COG4067	protein conserved in archaea
VFU_RS08015	COG0189	ligase activity
VFU_RS08020	COG0500	methyltransferase
VFU_RS08025	COG4106	trans-aconitate 2-methyltransferase activity
VFU_RS08030	COG1801	Protein of unknown function DUF72
VFU_RS08040	COG1435	thymidine kinase activity
VFU_RS08045	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VFU_RS08050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VFU_RS08055	COG0583	DNA-binding transcription factor activity
VFU_RS08070	COG2116	formate transmembrane transporter activity
VFU_RS08075	COG0390	transport system, permease component
VFU_RS08080	COG4459	periplasmic nitrate reductase
VFU_RS08085	COG3005	denitrification pathway
VFU_RS08090	COG0243	molybdopterin cofactor binding
VFU_RS08110	COG1227	inorganic diphosphatase activity
VFU_RS08125	COG4172	Belongs to the ABC transporter superfamily
VFU_RS08135	COG4171	peptide transport system, permease
VFU_RS08140	COG4168	peptide transport system, permease
VFU_RS08150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VFU_RS08155	COG1842	Phage shock protein A
VFU_RS08170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VFU_RS08185	COG2818	Glycosylase
VFU_RS08190	COG0626	cystathionine gamma-synthase activity
VFU_RS08200	COG0733	neurotransmitter:sodium symporter activity
VFU_RS08210	COG0564	pseudouridine synthase activity
VFU_RS08220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VFU_RS08225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VFU_RS08230	COG4136	ATPase activity
VFU_RS08235	COG4135	transport system, permease component
VFU_RS08240	COG4134	Bacterial extracellular solute-binding protein
VFU_RS08250	COG3313	Fe-S protein
VFU_RS08260	COG0842	Transport permease protein
VFU_RS08265	COG1131	(ABC) transporter
VFU_RS08275	COG0814	amino acid
VFU_RS08285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VFU_RS08290	COG1278	Cold shock
VFU_RS08315	COG1737	Transcriptional regulator
VFU_RS08330	COG3069	C4-dicarboxylate transmembrane transporter activity
VFU_RS08335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VFU_RS08345	COG3153	acetyltransferase
VFU_RS08355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VFU_RS08360	COG0642	Histidine kinase
VFU_RS08375	COG1061	Type III restriction enzyme res subunit
VFU_RS08385	COG2814	Major facilitator Superfamily
VFU_RS08395	COG0702	epimerase
VFU_RS08400	COG0534	Mate efflux family protein
VFU_RS08405	COG4181	ATPase activity
VFU_RS08420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VFU_RS08465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VFU_RS08480	COG3265	gluconokinase activity
VFU_RS08485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VFU_RS08515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VFU_RS08520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VFU_RS08535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VFU_RS08560	COG2989	Protein conserved in bacteria
VFU_RS08565	COG3108	Peptidase M15
VFU_RS08570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VFU_RS08585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VFU_RS08610	COG1846	Transcriptional regulator
VFU_RS08615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VFU_RS08620	COG0840	transmembrane signaling receptor activity
VFU_RS08625	COG2176	DNA-directed DNA polymerase activity
VFU_RS08640	COG1448	Aminotransferase
VFU_RS08655	COG0017	Asparaginyl-tRNA synthetase
VFU_RS08665	COG0720	synthase
VFU_RS08685	COG0577	efflux transmembrane transporter activity
VFU_RS08685	COG1136	(ABC) transporter
VFU_RS08690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VFU_RS08695	COG1760	l-serine dehydratase
VFU_RS08700	COG0814	amino acid
VFU_RS08705	COG0494	nUDIX hydrolase
VFU_RS08715	COG2205	protein histidine kinase activity
VFU_RS08715	COG0784	Response regulator, receiver
VFU_RS08720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VFU_RS08735	COG3106	COG3106 Predicted ATPase
VFU_RS08750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VFU_RS08770	COG0471	metal ion transport
VFU_RS08775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VFU_RS08775	COG4191	Histidine kinase
VFU_RS08790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VFU_RS08795	COG0778	Nitroreductase
VFU_RS08800	COG2991	Protein conserved in bacteria
VFU_RS08815	COG3250	beta-galactosidase activity
VFU_RS08825	COG1129	ABC transporter
VFU_RS08860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VFU_RS08860	COG2169	Transcriptional regulator
VFU_RS08870	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VFU_RS08875	COG0372	Belongs to the citrate synthase family
VFU_RS08880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VFU_RS08900	COG1566	PFAM secretion protein HlyD family protein
VFU_RS08905	COG2814	Major facilitator Superfamily
VFU_RS08925	COG2195	Cleaves the N-terminal amino acid of tripeptides
VFU_RS08930	COG2200	EAL domain
VFU_RS08940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VFU_RS08950	COG0625	glutathione transferase activity
VFU_RS08970	COG2731	YhcH YjgK YiaL family protein
VFU_RS08980	COG1349	DNA-binding transcription factor activity
VFU_RS08990	COG0395	ABC-type sugar transport system, permease component
VFU_RS08995	COG1175	transmembrane transport
VFU_RS09005	COG0039	L-malate dehydrogenase activity
VFU_RS09015	COG3040	lipid binding
VFU_RS09025	COG0811	peptide transport
VFU_RS09030	COG0811	peptide transport
VFU_RS09035	COG0848	biopolymer transport protein
VFU_RS09055	COG4667	esterase of the alpha-beta hydrolase superfamily
VFU_RS09060	COG1793	dna ligase
VFU_RS09075	COG0307	riboflavin synthase, alpha
VFU_RS09085	COG3001	Fructosamine kinase
VFU_RS09095	COG0791	NLP P60 protein
VFU_RS09110	COG3148	PFAM DTW domain containing protein
VFU_RS09115	COG1940	carbohydrate kinase activity
VFU_RS09125	COG0303	'Molybdopterin
VFU_RS09130	COG0746	molybdenum cofactor guanylyltransferase activity
VFU_RS09135	COG3842	ATPase activity
VFU_RS09140	COG4662	Binding-protein-dependent transport system inner membrane component
VFU_RS09150	COG2204	response regulator
VFU_RS09155	COG3852	Histidine kinase
VFU_RS09170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VFU_RS09190	COG3381	protein complex oligomerization
VFU_RS09200	COG0243	molybdopterin cofactor binding
VFU_RS09200	COG3383	formate dehydrogenase (NAD+) activity
VFU_RS09205	COG0437	4 iron, 4 sulfur cluster binding
VFU_RS09220	COG0004	ammonium transporteR
VFU_RS09225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VFU_RS09230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VFU_RS09240	COG1177	transmembrane transport
VFU_RS09250	COG3842	ATPase activity
VFU_RS09275	COG0589	response to stress
VFU_RS09280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VFU_RS09295	COG2217	Heavy metal translocating P-type atpase
VFU_RS09305	COG2010	Cytochrome c
VFU_RS09320	COG3278	Belongs to the heme-copper respiratory oxidase family
VFU_RS09335	COG0784	Response regulator, receiver
VFU_RS09335	COG2205	protein histidine kinase activity
VFU_RS09395	COG3120	sequence-specific DNA binding
VFU_RS09400	COG1067	ATP-dependent peptidase activity
VFU_RS09405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VFU_RS09420	COG0488	(ABC) transporter
VFU_RS09430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VFU_RS09430	COG0116	Belongs to the methyltransferase superfamily
VFU_RS09440	COG0167	dihydroorotate dehydrogenase activity
VFU_RS09445	COG2902	Dehydrogenase
VFU_RS09470	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VFU_RS09475	COG1956	GAF domain-containing protein
VFU_RS09480	COG1132	(ABC) transporter
VFU_RS09485	COG2995	paraquat-inducible protein a
VFU_RS09490	COG3008	intermembrane lipid transfer
VFU_RS09500	COG2996	Protein conserved in bacteria
VFU_RS09520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VFU_RS09525	COG1666	GTP binding
VFU_RS09530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VFU_RS09545	COG1115	amino acid carrier protein
VFU_RS09570	COG3501	Rhs element vgr protein
VFU_RS09580	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VFU_RS09595	COG1414	Transcriptional regulator
VFU_RS09600	COG0583	DNA-binding transcription factor activity
VFU_RS09635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VFU_RS09670	COG1643	Atp-dependent helicase
VFU_RS09675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VFU_RS09705	COG3706	GGDEF domain
VFU_RS09725	COG0443	Heat shock 70 kDa protein
VFU_RS09755	COG2999	glutathione oxidoreductase activity
VFU_RS09760	COG0657	acetylesterase activity
VFU_RS09770	COG0243	molybdopterin cofactor binding
VFU_RS09775	COG3005	denitrification pathway
VFU_RS09780	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VFU_RS09785	COG0602	queuosine metabolic process
VFU_RS09790	COG0561	phosphatase activity
VFU_RS09800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VFU_RS09805	COG4597	amino acid ABC transporter
VFU_RS09810	COG0765	amino acid transport
VFU_RS09815	COG1126	abc transporter atp-binding protein
VFU_RS09820	COG0670	Belongs to the BI1 family
VFU_RS09825	COG2920	part of a sulfur-relay system
VFU_RS09830	COG1254	Belongs to the acylphosphatase family
VFU_RS09835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VFU_RS09840	COG3391	amine dehydrogenase activity
VFU_RS09850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VFU_RS09880	COG5002	protein histidine kinase activity
VFU_RS09885	COG0745	RESPONSE REGULATOR receiver
VFU_RS09905	COG0668	transmembrane transport
VFU_RS09950	COG2897	thiosulfate sulfurtransferase activity
VFU_RS09955	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VFU_RS09960	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VFU_RS09965	COG0375	protein maturation
VFU_RS09970	COG0309	Hydrogenase expression formation protein (HypE)
VFU_RS09980	COG0298	carbon dioxide binding
VFU_RS09985	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
VFU_RS09995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VFU_RS10000	COG3604	Transcriptional regulator
VFU_RS10005	COG3383	formate dehydrogenase (NAD+) activity
VFU_RS10010	COG3383	formate dehydrogenase (NAD+) activity
VFU_RS10015	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
VFU_RS10020	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
VFU_RS10030	COG3260	NADH ubiquinone oxidoreductase 20
VFU_RS10035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VFU_RS10040	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
VFU_RS10040	COG3261	NADH dehydrogenase
VFU_RS10045	COG0650	Formate hydrogenlyase subunit 4
VFU_RS10050	COG0651	ATP synthesis coupled electron transport
VFU_RS10055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
VFU_RS10065	COG1921	L-seryl-tRNASec selenium transferase activity
VFU_RS10070	COG0835	chemotaxis
VFU_RS10070	COG0784	Response regulator, receiver
VFU_RS10080	COG4565	transcriptional regulatory protein
VFU_RS10085	COG3290	protein histidine kinase activity
VFU_RS10100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VFU_RS10120	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VFU_RS10125	COG3063	Type IV pilus biogenesis stability protein PilW
VFU_RS10140	COG1451	nucleotide metabolic process
VFU_RS10150	COG0583	DNA-binding transcription factor activity
VFU_RS10175	COG0110	maltose O-acetyltransferase activity
VFU_RS10180	COG0840	transmembrane signaling receptor activity
VFU_RS10190	COG1874	Beta-galactosidase
VFU_RS10200	COG3833	ABC-type maltose transport systems, permease component
VFU_RS10205	COG1175	transmembrane transport
VFU_RS10210	COG2182	Extracellular solute-binding protein
VFU_RS10220	COG1609	Transcriptional regulator
VFU_RS10265	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VFU_RS10270	COG4139	cobalamin transport
VFU_RS10275	COG2988	succinylglutamate desuccinylase activity
VFU_RS10290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VFU_RS10295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VFU_RS10300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VFU_RS10310	COG1823	symporter activity
VFU_RS10350	COG2925	Exonuclease
VFU_RS10355	COG1380	Effector of murein hydrolase LrgA
VFU_RS10360	COG1346	cytolysis
VFU_RS10365	COG0295	cytidine deaminase activity
VFU_RS10370	COG5001	Diguanylate cyclase
VFU_RS10400	COG0500	methyltransferase
VFU_RS10410	COG0776	regulation of translation
VFU_RS10415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VFU_RS10415	COG0072	phenylalanine-tRNA ligase activity
VFU_RS10420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VFU_RS10440	COG2133	pyrroloquinoline quinone binding
VFU_RS10475	COG0322	excinuclease ABC activity
VFU_RS10480	COG2197	response regulator
VFU_RS10485	COG0417	DNA replication proofreading
VFU_RS10495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VFU_RS10500	COG3099	Belongs to the UPF0263 family
VFU_RS10515	COG1228	amidohydrolase
VFU_RS10520	COG0010	Belongs to the arginase family
VFU_RS10530	COG2986	histidine ammonia-lyase
VFU_RS10545	COG0277	FAD linked oxidase domain protein
VFU_RS10545	COG0247	lactate metabolic process
VFU_RS10560	COG2885	chlorophyll binding
VFU_RS10580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VFU_RS10585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VFU_RS10595	COG2957	Belongs to the agmatine deiminase family
VFU_RS10605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VFU_RS10610	COG1012	belongs to the aldehyde dehydrogenase family
VFU_RS10615	COG1917	Cupin 2, conserved barrel domain protein
VFU_RS10615	COG1396	sequence-specific DNA binding
VFU_RS10620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VFU_RS10625	COG0174	glutamine synthetase
VFU_RS10630	COG1757	Na H antiporter
VFU_RS10645	COG0583	DNA-binding transcription factor activity
VFU_RS10660	COG1643	Atp-dependent helicase
VFU_RS10665	COG0281	malic enzyme
VFU_RS10675	COG0583	DNA-binding transcription factor activity
VFU_RS10690	COG0640	Transcriptional regulator
VFU_RS10710	COG2949	membrane
VFU_RS10720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VFU_RS10740	COG0492	ferredoxin-NADP+ reductase activity
VFU_RS10745	COG4988	ABC transporter
VFU_RS10750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VFU_RS10765	COG1187	pseudouridine synthase activity
VFU_RS10770	COG0009	L-threonylcarbamoyladenylate synthase
VFU_RS10780	COG0800	Aldolase
VFU_RS10785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VFU_RS10790	COG4145	pantothenate transmembrane transporter activity
VFU_RS10800	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VFU_RS10810	COG0837	glucose binding
VFU_RS10810	COG1737	Transcriptional regulator
VFU_RS10815	COG0613	PHP domain protein
VFU_RS10820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VFU_RS10825	COG0512	Glutamine amidotransferase of anthranilate synthase
VFU_RS10830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VFU_RS10835	COG0135	phosphoribosylanthranilate isomerase activity
VFU_RS10835	COG0134	indole-3-glycerol-phosphate synthase activity
VFU_RS10840	COG0133	tryptophan synthase activity
VFU_RS10845	COG0159	tryptophan synthase activity
VFU_RS10850	COG1301	dicarboxylic acid transport
VFU_RS10865	COG2350	Protein conserved in bacteria
VFU_RS10880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VFU_RS10890	COG1360	Flagellar Motor Protein
VFU_RS10895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VFU_RS10925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VFU_RS10930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VFU_RS10935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VFU_RS10940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VFU_RS10970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VFU_RS10980	COG1677	Flagellar hook-basal body complex protein FliE
VFU_RS11005	COG1706	bacterial-type flagellum-dependent cell motility
VFU_RS11010	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VFU_RS11015	COG4786	Flagellar basal body rod
VFU_RS11025	COG1749	Flagellar hook protein flgE
VFU_RS11035	COG1558	bacterial-type flagellum-dependent cell motility
VFU_RS11040	COG1815	bacterial-type flagellum-dependent cell motility
VFU_RS11050	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VFU_RS11085	COG0583	DNA-binding transcription factor activity
VFU_RS11100	COG0612	Peptidase, M16
VFU_RS11115	COG2771	luxR family
VFU_RS11115	COG2200	EAL domain
VFU_RS11120	COG0840	transmembrane signaling receptor activity
VFU_RS11130	COG0583	DNA-binding transcription factor activity
VFU_RS11140	COG0346	lactoylglutathione lyase activity
VFU_RS11150	COG0488	(ABC) transporter
VFU_RS11155	COG1032	radical SAM domain protein
VFU_RS11160	COG2211	Major facilitator Superfamily
VFU_RS11165	COG3940	Belongs to the glycosyl hydrolase 43 family
VFU_RS11175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VFU_RS11185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VFU_RS11185	COG4191	Histidine kinase
VFU_RS11200	COG3070	regulator of competence-specific genes
VFU_RS11220	COG0076	glutamate decarboxylase activity
VFU_RS11225	COG1737	Transcriptional regulator
VFU_RS11235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VFU_RS11245	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VFU_RS11250	COG1960	acyl-CoA dehydrogenase activity
VFU_RS11270	COG1012	belongs to the aldehyde dehydrogenase family
VFU_RS11280	COG0700	Nucleoside recognition
VFU_RS11285	COG3366	ferrous iron transmembrane transporter activity
VFU_RS11305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VFU_RS11310	COG3716	PTS system mannose fructose sorbose family IID component
VFU_RS11320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VFU_RS11325	COG2222	sugar isomerase
VFU_RS11335	COG1349	DNA-binding transcription factor activity
VFU_RS11340	COG1349	DNA-binding transcription factor activity
VFU_RS11355	COG5002	protein histidine kinase activity
VFU_RS11355	COG0784	Response regulator, receiver
VFU_RS11365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VFU_RS11370	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VFU_RS11375	COG2885	chlorophyll binding
VFU_RS11380	COG0823	Involved in the tonB-independent uptake of proteins
VFU_RS11395	COG0811	peptide transport
VFU_RS11400	COG0824	Thioesterase
VFU_RS11415	COG1294	oxidase, subunit
VFU_RS11420	COG1271	oxidase subunit
VFU_RS11425	COG2255	four-way junction helicase activity
VFU_RS11430	COG0632	four-way junction helicase activity
VFU_RS11435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VFU_RS11440	COG0215	cysteine-tRNA ligase activity
VFU_RS11445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VFU_RS11450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VFU_RS11455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VFU_RS11460	COG3012	SEC-C Motif Domain Protein
VFU_RS11465	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VFU_RS11475	COG1199	ATP-dependent helicase activity
VFU_RS11480	COG3923	Primosomal replication protein n
VFU_RS11490	COG0840	transmembrane signaling receptor activity
VFU_RS11495	COG0708	Exodeoxyribonuclease III
VFU_RS11500	COG4160	amino acid transport
VFU_RS11540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VFU_RS11550	COG3013	Belongs to the UPF0304 family
VFU_RS11555	COG3713	MltA-interacting MipA family protein
VFU_RS11560	COG2766	serine protein kinase
VFU_RS11565	COG2718	Belongs to the UPF0229 family
VFU_RS11570	COG2719	SpoVR family
VFU_RS11575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VFU_RS11585	COG1663	tetraacyldisaccharide 4'-kinase activity
VFU_RS11590	COG1132	(ABC) transporter
VFU_RS11595	COG0658	competence protein
VFU_RS11595	COG2333	competence protein COMEC
VFU_RS11605	COG4591	ABC-type transport system involved in lipoprotein release permease component
VFU_RS11610	COG1136	(ABC) transporter
VFU_RS11615	COG4591	ABC-type transport system involved in lipoprotein release permease component
VFU_RS11640	COG1252	NADH dehydrogenase
VFU_RS11645	COG3150	esterase
VFU_RS11670	COG0537	adenosine 5'-monophosphoramidase activity
VFU_RS11685	COG2186	Transcriptional regulator
VFU_RS11690	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VFU_RS11695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VFU_RS11700	COG1674	ftsk spoiiie
VFU_RS11705	COG1522	sequence-specific DNA binding
VFU_RS11710	COG0686	Belongs to the AlaDH PNT family
VFU_RS11720	COG0583	DNA-binding transcription factor activity
VFU_RS11740	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VFU_RS11745	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VFU_RS11750	COG0776	regulation of translation
VFU_RS11755	COG0539	negative regulation of cytoplasmic translation
VFU_RS11760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VFU_RS11765	COG1555	photosystem II stabilization
VFU_RS11770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VFU_RS11775	COG0776	regulation of translation
VFU_RS11780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VFU_RS11785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VFU_RS11795	COG0544	peptidyl-prolyl cis-trans isomerase activity
VFU_RS11800	COG4191	Histidine kinase
VFU_RS11805	COG2204	response regulator
VFU_RS11810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VFU_RS11815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VFU_RS11820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VFU_RS11825	COG1404	Belongs to the peptidase S8 family
VFU_RS11850	COG1760	l-serine dehydratase
VFU_RS11860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VFU_RS11860	COG3153	acetyltransferase
VFU_RS11880	COG4589	Belongs to the CDS family
VFU_RS11915	COG2197	response regulator
VFU_RS11920	COG3851	Histidine kinase
VFU_RS11925	COG2271	Major facilitator Superfamily
VFU_RS11930	COG1840	ABC-type Fe3 transport system, periplasmic component
VFU_RS11940	COG3842	ATPase activity
VFU_RS11950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VFU_RS11955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VFU_RS11965	COG2951	lytic endotransglycosylase activity
VFU_RS11970	COG3100	YcgL domain-containing protein
VFU_RS11975	COG0850	regulation of cytokinetic process
VFU_RS11980	COG2894	cell division
VFU_RS11985	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VFU_RS11995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VFU_RS12000	COG0318	PFAM AMP-dependent synthetase and ligase
VFU_RS12005	COG2267	carboxylic ester hydrolase activity
VFU_RS12020	COG1214	PFAM Peptidase M22, glycoprotease
VFU_RS12025	COG1199	ATP-dependent helicase activity
VFU_RS12035	COG0788	formyltetrahydrofolate deformylase activity
VFU_RS12040	COG0446	pyridine nucleotide-disulphide oxidoreductase
VFU_RS12040	COG1902	pentaerythritol trinitrate reductase activity
VFU_RS12045	COG0616	signal peptide processing
VFU_RS12050	COG0252	asparaginase activity
VFU_RS12055	COG3139	Protein of unknown function (DUF1315)
VFU_RS12065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VFU_RS12070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VFU_RS12075	COG0676	glucose-6-phosphate 1-epimerase activity
VFU_RS12080	COG2226	methyltransferase
VFU_RS12095	COG0653	protein targeting
VFU_RS12225	COG4695	Portal protein
VFU_RS12320	COG4974	Belongs to the 'phage' integrase family
VFU_RS12325	COG2983	Belongs to the UPF0260 family
VFU_RS12335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VFU_RS12340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VFU_RS12345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VFU_RS12355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VFU_RS12360	COG2832	Protein of unknown function (DUF454)
VFU_RS12370	COG0745	RESPONSE REGULATOR receiver
VFU_RS12375	COG0583	DNA-binding transcription factor activity
VFU_RS12380	COG0778	Nitroreductase
VFU_RS12385	COG1250	3-hydroxyacyl-CoA dehydrogenase
VFU_RS12385	COG1024	Enoyl-CoA hydratase
VFU_RS12390	COG0183	Belongs to the thiolase family
VFU_RS12410	COG2067	long-chain fatty acid transport protein
VFU_RS12415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VFU_RS12430	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VFU_RS12435	COG2982	Protein involved in outer membrane biogenesis
VFU_RS12440	COG0572	uridine kinase
VFU_RS12460	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VFU_RS12470	COG0517	IMP dehydrogenase activity
VFU_RS12470	COG0617	tRNA 3'-terminal CCA addition
VFU_RS12470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VFU_RS12475	COG3706	GGDEF domain
VFU_RS12480	COG0314	molybdopterin synthase activity
VFU_RS12485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VFU_RS12490	COG0315	cyclic pyranopterin monophosphate synthase activity
VFU_RS12495	COG0521	Mo-molybdopterin cofactor biosynthetic process
VFU_RS12500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VFU_RS12505	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VFU_RS12510	COG2198	Histidine kinase
VFU_RS12515	COG2204	response regulator
VFU_RS12520	COG0556	nucleotide-excision repair
VFU_RS12530	COG1882	Formate acetyltransferase
VFU_RS12535	COG4657	Part of a membrane complex involved in electron transport
VFU_RS12540	COG2878	Part of a membrane complex involved in electron transport
VFU_RS12545	COG4656	Part of a membrane complex involved in electron transport
VFU_RS12550	COG4658	electron transport chain
VFU_RS12555	COG4659	FMN binding
VFU_RS12560	COG4660	Part of a membrane complex involved in electron transport
VFU_RS12565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VFU_RS12570	COG0346	lactoylglutathione lyase activity
VFU_RS12585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VFU_RS12590	COG2056	Na+-H+ antiporter family
VFU_RS12595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VFU_RS12600	COG1286	toxin biosynthetic process
VFU_RS12605	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VFU_RS12610	COG0285	dihydrofolate synthase activity
VFU_RS12615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VFU_RS12620	COG0101	tRNA pseudouridine synthase activity
VFU_RS12635	COG2190	(PTS) system
VFU_RS12635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VFU_RS12635	COG1263	PTS System
VFU_RS12640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VFU_RS12645	COG1846	Transcriptional regulator
VFU_RS12645	COG1940	carbohydrate kinase activity
VFU_RS12650	COG4651	solute:proton antiporter activity
VFU_RS12650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VFU_RS12655	COG0367	asparagine synthase
VFU_RS12670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VFU_RS12680	COG0326	Molecular chaperone. Has ATPase activity
VFU_RS12685	COG3710	Transcriptional regulator
VFU_RS12700	COG0622	Phosphoesterase
VFU_RS12725	COG1090	epimerase
VFU_RS12730	COG0300	oxidoreductase activity
VFU_RS12740	COG3118	belongs to the thioredoxin family
VFU_RS12745	COG0330	HflC and HflK could
VFU_RS12755	COG0789	Transcriptional regulator
VFU_RS12770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VFU_RS12775	COG3115	cell septum assembly
VFU_RS12780	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VFU_RS12785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VFU_RS12790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VFU_RS12800	COG2190	(PTS) system
VFU_RS12805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VFU_RS12810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VFU_RS12815	COG1702	phosphate starvation-inducible protein PhoH
VFU_RS12820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VFU_RS12825	COG4535	Mg2 and Co2 transporter CorC
VFU_RS12830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VFU_RS12835	COG2888	peptidyl-tyrosine sulfation
VFU_RS12840	COG0495	leucyl-tRNA aminoacylation
VFU_RS12845	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VFU_RS12850	COG1466	dna polymerase III delta subunit
VFU_RS12855	COG0799	negative regulation of ribosome biogenesis
VFU_RS12860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VFU_RS12865	COG0768	penicillin binding
VFU_RS12870	COG0772	Belongs to the SEDS family
VFU_RS12875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VFU_RS12880	COG1686	Belongs to the peptidase S11 family
VFU_RS12885	COG2921	Belongs to the UPF0250 family
VFU_RS12890	COG0321	lipoyl(octanoyl) transferase activity
VFU_RS12895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VFU_RS12905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VFU_RS12915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VFU_RS12920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VFU_RS12950	COG2197	response regulator
VFU_RS12955	COG3851	Histidine kinase
VFU_RS12960	COG2271	Major facilitator Superfamily
VFU_RS12965	COG0366	Alpha amylase catalytic
VFU_RS12970	COG1263	PTS System
VFU_RS12970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VFU_RS12985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VFU_RS12990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VFU_RS12995	COG2011	ABC-type metal ion transport system permease component
VFU_RS13000	COG1464	Belongs to the NlpA lipoprotein family
VFU_RS13005	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VFU_RS13015	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VFU_RS13015	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VFU_RS13030	COG1611	Belongs to the LOG family
VFU_RS13035	COG1611	Belongs to the LOG family
VFU_RS13040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VFU_RS13050	COG2363	Small membrane protein
VFU_RS13060	COG0583	DNA-binding transcription factor activity
VFU_RS13065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VFU_RS13065	COG0301	tRNA thio-modification
VFU_RS13075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VFU_RS13080	COG1722	exodeoxyribonuclease VII activity
VFU_RS13085	COG0142	geranyltranstransferase activity
VFU_RS13090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VFU_RS13095	COG0564	pseudouridine synthase activity
VFU_RS13100	COG3098	single-species biofilm formation
VFU_RS13125	COG1671	Belongs to the UPF0178 family
VFU_RS13135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VFU_RS13140	COG0254	rRNA binding
VFU_RS13145	COG1720	tRNA m6t6A37 methyltransferase activity
VFU_RS13150	COG0442	prolyl-tRNA aminoacylation
VFU_RS13180	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VFU_RS13190	COG0583	DNA-binding transcription factor activity
VFU_RS13200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VFU_RS13205	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VFU_RS13235	COG0484	heat shock protein binding
VFU_RS13240	COG0443	Heat shock 70 kDa protein
VFU_RS13250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VFU_RS13255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VFU_RS13260	COG0497	DNA recombination
VFU_RS13265	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VFU_RS13270	COG2914	Belongs to the UPF0125 (RnfH) family
VFU_RS13275	COG2867	negative regulation of translational initiation
VFU_RS13280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VFU_RS13300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VFU_RS13305	COG0583	DNA-binding transcription factor activity
VFU_RS13320	COG1115	amino acid carrier protein
VFU_RS13340	COG3121	Chaperone
VFU_RS13345	COG3188	usher protein
VFU_RS13360	COG3710	Transcriptional regulator
VFU_RS13365	COG1584	GPR1 FUN34 yaaH family protein
VFU_RS13415	COG4691	Plasmid stability protein
VFU_RS13435	COG0582	viral genome integration into host DNA
VFU_RS13440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VFU_RS13440	COG0519	Catalyzes the synthesis of GMP from XMP
VFU_RS13445	COG0516	GMP reductase activity
VFU_RS13445	COG0517	IMP dehydrogenase activity
VFU_RS13450	COG1570	exodeoxyribonuclease VII activity
VFU_RS13465	COG1160	GTP binding
VFU_RS13470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VFU_RS13475	COG2976	Protein conserved in bacteria
VFU_RS13480	COG0124	histidyl-tRNA synthetase
VFU_RS13500	COG0105	UTP biosynthetic process
VFU_RS13505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VFU_RS13510	COG2975	iron-sulfur cluster assembly
VFU_RS13515	COG0633	Ferredoxin
VFU_RS13520	COG0443	Heat shock 70 kDa protein
VFU_RS13535	COG0822	iron-sulfur transferase activity
VFU_RS13540	COG1104	cysteine desulfurase activity
VFU_RS13545	COG1959	2 iron, 2 sulfur cluster binding
VFU_RS13550	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VFU_RS13555	COG0483	inositol monophosphate 1-phosphatase activity
VFU_RS13560	COG1335	isochorismatase
VFU_RS13565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VFU_RS13570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VFU_RS13575	COG1862	Preprotein translocase
VFU_RS13585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VFU_RS13590	COG0517	IMP dehydrogenase activity
VFU_RS13605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VFU_RS13610	COG0583	DNA-binding transcription factor activity
VFU_RS13615	COG0450	alkyl hydroperoxide reductase
VFU_RS13620	COG3142	Participates in the control of copper homeostasis
VFU_RS13630	COG0704	Plays a role in the regulation of phosphate uptake
VFU_RS13635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VFU_RS13640	COG0581	inorganic phosphate transmembrane transporter activity
VFU_RS13645	COG0573	inorganic phosphate transmembrane transporter activity
VFU_RS13650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VFU_RS13655	COG0248	Ppx GppA phosphatase
VFU_RS13665	COG5002	protein histidine kinase activity
VFU_RS13680	COG0826	peptidase U32
VFU_RS13685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VFU_RS13690	COG0477	Major facilitator Superfamily
VFU_RS13700	COG1595	DNA-templated transcription, initiation
VFU_RS13710	COG3248	Nucleoside-binding outer membrane protein
VFU_RS13715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VFU_RS13720	COG0693	protein deglycase activity
VFU_RS13725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VFU_RS13730	COG2166	iron-sulfur cluster assembly
VFU_RS13735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VFU_RS13740	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VFU_RS13750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VFU_RS13750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VFU_RS13760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VFU_RS13765	COG1074	ATP-dependent DNA helicase activity
VFU_RS13770	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VFU_RS13780	COG0583	DNA-binding transcription factor activity
VFU_RS13785	COG3141	response to X-ray
VFU_RS13790	COG2171	N-acyltransferase activity
VFU_RS13795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VFU_RS13825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VFU_RS13830	COG2017	converts alpha-aldose to the beta-anomer
VFU_RS13840	COG2059	Chromate
VFU_RS13895	COG4964	Belongs to the GSP D family
VFU_RS13925	COG1022	Amp-dependent synthetase and ligase
VFU_RS13930	COG0583	DNA-binding transcription factor activity
VFU_RS13940	COG0583	DNA-binding transcription factor activity
VFU_RS13945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VFU_RS13950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VFU_RS13960	COG0560	Phosphoserine phosphatase
VFU_RS13970	COG0813	purine-nucleoside phosphorylase activity
VFU_RS13975	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VFU_RS13980	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VFU_RS13985	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VFU_RS13995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VFU_RS14000	COG0084	hydrolase, TatD family'
VFU_RS14005	COG3022	response to hydroperoxide
VFU_RS14025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VFU_RS14035	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VFU_RS14040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VFU_RS14045	COG0083	homoserine kinase activity
VFU_RS14060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VFU_RS14070	COG0745	RESPONSE REGULATOR receiver
VFU_RS14080	COG0784	Response regulator, receiver
VFU_RS14080	COG2198	Histidine kinase
VFU_RS14080	COG5002	protein histidine kinase activity
VFU_RS14085	COG5001	Diguanylate cyclase
VFU_RS14085	COG4251	negative regulation of phosphorylation
VFU_RS14085	COG3706	GGDEF domain
VFU_RS14085	COG2203	Gaf domain
VFU_RS14090	COG1242	4 iron, 4 sulfur cluster binding
VFU_RS14095	COG0070	glutamate synthase
VFU_RS14095	COG0069	glutamate synthase activity
VFU_RS14095	COG0067	glutamate synthase
VFU_RS14105	COG0070	glutamate synthase
VFU_RS14105	COG0069	glutamate synthase activity
VFU_RS14105	COG0067	glutamate synthase
VFU_RS14110	COG0493	'glutamate synthase
VFU_RS14120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VFU_RS14130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VFU_RS14135	COG2860	membrane
VFU_RS14155	COG0583	DNA-binding transcription factor activity
VFU_RS14160	COG0730	response to heat
VFU_RS14175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VFU_RS14180	COG0505	Belongs to the CarA family
VFU_RS14185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VFU_RS14190	COG0494	nUDIX hydrolase
VFU_RS14195	COG0653	protein targeting
VFU_RS14205	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VFU_RS14210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VFU_RS14215	COG0849	cell division
VFU_RS14220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VFU_RS14225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VFU_RS14230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VFU_RS14235	COG0772	Belongs to the SEDS family
VFU_RS14240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VFU_RS14250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VFU_RS14255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VFU_RS14260	COG0768	penicillin binding
VFU_RS14265	COG3116	cell division
VFU_RS14275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VFU_RS14280	COG3107	peptidoglycan biosynthetic process
VFU_RS14285	COG0792	nuclease activity
VFU_RS14290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VFU_RS14295	COG2823	Periplasmic or secreted lipoprotein
VFU_RS14300	COG2969	positive regulation of protein catabolic process
VFU_RS14305	COG0625	glutathione transferase activity
VFU_RS14310	COG2857	Cytochrome c1
VFU_RS14315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VFU_RS14320	COG0723	plastoquinol--plastocyanin reductase activity
VFU_RS14330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VFU_RS14335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VFU_RS14340	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VFU_RS14345	COG3105	Protein conserved in bacteria
VFU_RS14350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VFU_RS14355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VFU_RS14360	COG0335	large ribosomal subunit rRNA binding
VFU_RS14365	COG0336	Belongs to the RNA methyltransferase TrmD family
VFU_RS14370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VFU_RS14380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VFU_RS14385	COG4137	Cytochrome C assembly protein
VFU_RS14390	COG4536	flavin adenine dinucleotide binding
VFU_RS14395	COG1854	S-ribosylhomocysteine lyase activity
VFU_RS14405	COG2918	glutathione biosynthetic process
VFU_RS14410	COG0612	Peptidase, M16
VFU_RS14415	COG1238	metal cluster binding
VFU_RS14425	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VFU_RS14430	COG0511	ligase activity, forming carbon-carbon bonds
VFU_RS14430	COG5016	pyruvate
VFU_RS14435	COG3630	sodium ion export across plasma membrane
VFU_RS14470	COG0527	aspartate kinase activity
VFU_RS14475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VFU_RS14480	COG2137	regulation of response to DNA damage stimulus
VFU_RS14485	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VFU_RS14490	COG1546	Belongs to the CinA family
VFU_RS14495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VFU_RS14500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VFU_RS14505	COG4942	peptidase
VFU_RS14505	COG1388	LysM domain
VFU_RS14510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VFU_RS14515	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VFU_RS14520	COG0585	pseudouridine synthase activity
VFU_RS14530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VFU_RS14535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VFU_RS14540	COG1968	undecaprenyl-diphosphatase activity
VFU_RS14545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VFU_RS14550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VFU_RS14555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VFU_RS14565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VFU_RS14575	COG1610	YqeY-like protein
VFU_RS14580	COG0358	DNA primase activity
VFU_RS14675	COG2378	regulation of single-species biofilm formation
VFU_RS14685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VFU_RS14690	COG1263	PTS System
VFU_RS14690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VFU_RS14695	COG1609	Transcriptional regulator
VFU_RS14705	COG2239	Acts as a magnesium transporter
VFU_RS14720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VFU_RS14725	COG1349	DNA-binding transcription factor activity
VFU_RS14755	COG1279	arginine transmembrane transporter activity
VFU_RS14765	COG0668	transmembrane transport
VFU_RS14770	COG0191	fructose-bisphosphate aldolase activity
VFU_RS14775	COG0126	phosphoglycerate kinase activity
VFU_RS14780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VFU_RS14785	COG4771	TonB-dependent receptor
VFU_RS14790	COG0583	DNA-binding transcription factor activity
VFU_RS14795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VFU_RS14800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VFU_RS14815	COG2356	endonuclease I
VFU_RS14820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VFU_RS14825	COG0189	ligase activity
VFU_RS14830	COG1678	Uncharacterized ACR, COG1678
VFU_RS14835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VFU_RS14850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VFU_RS14855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VFU_RS14860	COG0762	integral membrane protein
VFU_RS14865	COG1872	DUF167
VFU_RS14875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VFU_RS14880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VFU_RS14885	COG2066	Belongs to the glutaminase family
VFU_RS14890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VFU_RS14895	COG1194	a g-specific adenine glycosylase
VFU_RS14900	COG1120	ATPase activity
VFU_RS14905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VFU_RS14910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VFU_RS14915	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VFU_RS14920	COG0741	lytic transglycosylase activity
VFU_RS14970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VFU_RS14975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VFU_RS14980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VFU_RS14985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VFU_RS14990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VFU_RS14995	COG2967	ApaG domain
VFU_RS15000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VFU_RS15010	COG3610	response to peptide
VFU_RS15015	COG2966	Psort location CytoplasmicMembrane, score
VFU_RS15020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VFU_RS15030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VFU_RS15035	COG0142	geranyltranstransferase activity
VFU_RS15040	COG0531	amino acid
VFU_RS15045	COG0039	L-malate dehydrogenase activity
VFU_RS15050	COG1438	arginine binding
VFU_RS15065	COG0589	response to stress
VFU_RS15085	COG0312	modulator of DNA gyrase
VFU_RS15090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VFU_RS15095	COG3164	Protein of unknown function
VFU_RS15100	COG1530	ribonuclease E activity
VFU_RS15105	COG0424	maF-like protein
VFU_RS15110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VFU_RS15115	COG1792	Involved in formation and maintenance of cell shape
VFU_RS15120	COG1077	Cell shape determining protein MreB Mrl
VFU_RS15160	COG2165	general secretion pathway protein
VFU_RS15170	COG1459	type II secretion system
VFU_RS15175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VFU_RS15185	COG3409	Peptidoglycan-binding domain 1 protein
VFU_RS15185	COG3267	Type II secretory pathway component ExeA
VFU_RS15210	COG2199	diguanylate cyclase activity
VFU_RS15210	COG2200	EAL domain
VFU_RS15215	COG0629	single-stranded DNA binding
VFU_RS15230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VFU_RS15240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VFU_RS15245	COG0527	aspartate kinase activity
VFU_RS15250	COG0646	methionine synthase
VFU_RS15250	COG1410	methionine synthase
VFU_RS15290	COG0175	sulfate reduction
VFU_RS15300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VFU_RS15320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VFU_RS15325	COG0735	belongs to the Fur family
VFU_RS15345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VFU_RS15360	COG0359	binds to the 23S rRNA
VFU_RS15370	COG0360	Binds together with S18 to 16S ribosomal RNA
VFU_RS15380	COG2906	2 iron, 2 sulfur cluster binding
VFU_RS15580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VFU_RS15630	COG1072	(Pantothenic acid kinase))
VFU_RS15665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VFU_RS16035	COG0318	PFAM AMP-dependent synthetase and ligase
VFU_RS16145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VFU_RS16235	COG0438	transferase activity, transferring glycosyl groups
VFU_RS16595	COG0514	ATP-dependent DNA helicase (RecQ)
VFU_RS16870	COG0242	peptide deformylase activity
VFU_RS17140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VFU_RS17170	COG0583	DNA-binding transcription factor activity
VFU_RS17195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VFU_RS17445	COG1129	ABC transporter
VFU_RS17450	COG1129	ABC transporter
VFU_RS17740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VFU_RS17845	COG1217	gtp-binding protein TYPA
VFU_RS18900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VFU_RS18960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VFU_RS19555	COG0508	dehydrogenase complex catalyzes the overall conversion of
VFU_RS19610	COG1643	Atp-dependent helicase
VFU_RS19635	COG1049	propionate catabolic process, 2-methylcitrate cycle
VFU_RS19945	COG0826	peptidase U32
VFU_RS20050	COG1283	sodium-dependent phosphate transmembrane transporter activity
VFU_RS20310	COG2871	sodium ion transport
VFU_RS20455	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VFU_RS20480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VFU_RS20525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VFU_RS20550	COG0037	tRNA processing
VFU_RS20555	COG0037	tRNA processing
VFU_RS20600	COG1960	acyl-CoA dehydrogenase activity
VFU_RS20760	COG1706	bacterial-type flagellum-dependent cell motility
VFU_RS21515	COG0659	secondary active sulfate transmembrane transporter activity
VFU_RS21740	COG0477	Major facilitator Superfamily
VFU_RS22435	COG4774	siderophore transport
VFU_RS22455	COG1263	PTS System
VFU_RS22455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VFU_RS22655	COG4120	Belongs to the binding-protein-dependent transport system permease family
VFU_RS22695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VFU_RS22705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VFU_RS22730	COG0243	molybdopterin cofactor binding