locus-tag	class	description
Vgang_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Vgang_RS00015	COG0706	membrane insertase activity
Vgang_RS00025	COG0594	ribonuclease P activity
Vgang_RS00035	COG1126	abc transporter atp-binding protein
Vgang_RS00045	COG4178	(ABC) transporter
Vgang_RS00055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Vgang_RS00060	COG0592	DNA-directed DNA polymerase activity
Vgang_RS00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Vgang_RS00070	COG0187	DNA topoisomerase II activity
Vgang_RS00075	COG0071	Belongs to the small heat shock protein (HSP20) family
Vgang_RS00080	COG3977	Valine--pyruvate aminotransferase
Vgang_RS00090	COG0752	glycyl-tRNA synthetase alpha subunit
Vgang_RS00095	COG1971	Probably functions as a manganese efflux pump
Vgang_RS00105	COG0425	Belongs to the sulfur carrier protein TusA family
Vgang_RS00110	COG1965	Belongs to the frataxin family
Vgang_RS00120	COG0019	diaminopimelate decarboxylase activity
Vgang_RS00125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Vgang_RS00135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Vgang_RS00140	COG1011	Hydrolase
Vgang_RS00145	COG3148	PFAM DTW domain containing protein
Vgang_RS00160	COG0561	phosphatase activity
Vgang_RS00165	COG2267	carboxylic ester hydrolase activity
Vgang_RS00170	COG0640	Transcriptional regulator
Vgang_RS00175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vgang_RS00210	COG2095	MarC family integral membrane protein
Vgang_RS00220	COG0742	ribosomal rna small subunit methyltransferase
Vgang_RS00225	COG0552	protein localization to endoplasmic reticulum
Vgang_RS00230	COG2884	Cell division ATP-binding protein ftsE
Vgang_RS00235	COG2177	Part of the ABC transporter FtsEX involved in
Vgang_RS00245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vgang_RS00255	COG3161	chorismate lyase activity
Vgang_RS00260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Vgang_RS00265	COG2937	Belongs to the GPAT DAPAT family
Vgang_RS00270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Vgang_RS00275	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Vgang_RS00280	COG0534	Mate efflux family protein
Vgang_RS00285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vgang_RS00295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Vgang_RS00300	COG4206	TonB-dependent receptor
Vgang_RS00305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Vgang_RS00345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vgang_RS00355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Vgang_RS00365	COG1072	(Pantothenic acid kinase))
Vgang_RS00395	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Vgang_RS00400	COG0250	Participates in transcription elongation, termination and antitermination
Vgang_RS00415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Vgang_RS00425	COG0085	RNA polymerase activity
Vgang_RS00455	COG1742	UPF0060 membrane protein
Vgang_RS00465	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Vgang_RS00470	COG2816	NAD+ diphosphatase activity
Vgang_RS00485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vgang_RS00500	COG1573	uracil-dna glycosylase
Vgang_RS00525	COG0151	Belongs to the GarS family
Vgang_RS00530	COG0138	bifunctional purine biosynthesis protein purh
Vgang_RS00540	COG1609	Transcriptional regulator
Vgang_RS00565	COG1917	Cupin 2, conserved barrel domain protein
Vgang_RS00565	COG2169	Transcriptional regulator
Vgang_RS00580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Vgang_RS00590	COG2264	protein methyltransferase activity
Vgang_RS00595	COG4145	pantothenate transmembrane transporter activity
Vgang_RS00600	COG3924	membrane
Vgang_RS00605	COG0439	Biotin carboxylase
Vgang_RS00610	COG0511	ligase activity, forming carbon-carbon bonds
Vgang_RS00615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Vgang_RS00620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vgang_RS00635	COG2814	Major facilitator Superfamily
Vgang_RS00640	COG2205	protein histidine kinase activity
Vgang_RS00650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vgang_RS00660	COG2095	MarC family integral membrane protein
Vgang_RS00665	COG3263	regulation of cellular component size
Vgang_RS00675	COG4232	protein-disulfide reductase activity
Vgang_RS00680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Vgang_RS00685	COG1027	Aspartate ammonia-lyase
Vgang_RS00690	COG3030	protein affecting phage T7 exclusion by the F plasmid
Vgang_RS00695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Vgang_RS00700	COG2205	protein histidine kinase activity
Vgang_RS00705	COG0745	RESPONSE REGULATOR receiver
Vgang_RS00710	COG3678	ATP-independent chaperone mediated protein folding
Vgang_RS00715	COG3385	transposase activity
Vgang_RS00720	COG1280	lysine exporter protein (LysE YggA)
Vgang_RS00725	COG2962	Rard protein
Vgang_RS00730	COG0514	ATP-dependent DNA helicase (RecQ)
Vgang_RS00740	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Vgang_RS00745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Vgang_RS00745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Vgang_RS00750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Vgang_RS00785	COG2204	response regulator
Vgang_RS00790	COG3852	Histidine kinase
Vgang_RS00800	COG0174	glutamine synthetase
Vgang_RS00805	COG1217	gtp-binding protein TYPA
Vgang_RS00815	COG1490	D-aminoacyl-tRNA deacylase activity
Vgang_RS00820	COG0456	acetyltransferase
Vgang_RS00830	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Vgang_RS00840	COG2963	transposase activity
Vgang_RS00845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Vgang_RS00850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Vgang_RS00855	COG3031	protein transport across the cell outer membrane
Vgang_RS00865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vgang_RS00870	COG1459	type II secretion system
Vgang_RS00875	COG2165	general secretion pathway protein
Vgang_RS00880	COG2165	general secretion pathway protein
Vgang_RS00885	COG2165	general secretion pathway protein
Vgang_RS00890	COG4795	General secretion pathway protein
Vgang_RS00895	COG3156	type II secretion system protein K
Vgang_RS00900	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Vgang_RS00905	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Vgang_RS00915	COG0494	nUDIX hydrolase
Vgang_RS00920	COG1218	3'(2'),5'-bisphosphate nucleotidase
Vgang_RS00935	COG0596	Alpha beta hydrolase
Vgang_RS00940	COG1349	DNA-binding transcription factor activity
Vgang_RS00945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Vgang_RS00950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Vgang_RS00965	COG2183	response to ionizing radiation
Vgang_RS00970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vgang_RS00985	COG2233	PERMEase
Vgang_RS00990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Vgang_RS00995	COG1560	Kdo2-lipid A biosynthetic process
Vgang_RS01000	COG1309	transcriptional regulator
Vgang_RS01005	COG0756	dUTP diphosphatase activity
Vgang_RS01010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Vgang_RS01015	COG2003	Belongs to the UPF0758 family
Vgang_RS01025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Vgang_RS01030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Vgang_RS01040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Vgang_RS01045	COG0438	transferase activity, transferring glycosyl groups
Vgang_RS01055	COG0463	Glycosyl transferase, family 2
Vgang_RS01060	COG0859	PFAM glycosyl transferase family 9
Vgang_RS01065	COG3642	lipopolysaccharide core region biosynthetic process
Vgang_RS01070	COG1519	Transferase
Vgang_RS01075	COG0859	PFAM glycosyl transferase family 9
Vgang_RS01085	COG0438	transferase activity, transferring glycosyl groups
Vgang_RS01095	COG1560	Kdo2-lipid A biosynthetic process
Vgang_RS01130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vgang_RS01135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Vgang_RS01135	COG0463	Glycosyl transferase, family 2
Vgang_RS01140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Vgang_RS01160	COG0438	transferase activity, transferring glycosyl groups
Vgang_RS01185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vgang_RS01200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Vgang_RS01245	COG1216	Glycosyl transferase, family 2
Vgang_RS01255	COG3177	Filamentation induced by cAMP protein fic
Vgang_RS01260	COG3550	peptidyl-serine autophosphorylation
Vgang_RS01265	COG1396	sequence-specific DNA binding
Vgang_RS01325	COG2337	Toxic component of a toxin-antitoxin (TA) module
Vgang_RS01335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Vgang_RS01380	COG3188	usher protein
Vgang_RS01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vgang_RS01415	COG1263	PTS System
Vgang_RS01420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vgang_RS01425	COG1621	beta-fructofuranosidase activity
Vgang_RS01440	COG0489	protein tyrosine kinase activity
Vgang_RS01440	COG3206	protein involved in exopolysaccharide biosynthesis
Vgang_RS01455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Vgang_RS01480	COG3706	GGDEF domain
Vgang_RS01495	COG4942	peptidase
Vgang_RS01500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Vgang_RS01505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vgang_RS01510	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Vgang_RS01520	COG1045	serine acetyltransferase
Vgang_RS01525	COG0534	Mate efflux family protein
Vgang_RS01535	COG0459	protein refolding
Vgang_RS01545	COG0366	Alpha amylase catalytic
Vgang_RS01550	COG2190	(PTS) system
Vgang_RS01550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vgang_RS01550	COG1263	PTS System
Vgang_RS01570	COG0583	DNA-binding transcription factor activity
Vgang_RS01575	COG1620	l-lactate permease
Vgang_RS01595	COG1119	ATPase activity
Vgang_RS01600	COG1285	pathogenesis
Vgang_RS01605	COG0604	alcohol dehydrogenase
Vgang_RS01615	COG3609	addiction module antidote protein, CC2985 family
Vgang_RS01625	COG1509	lysine 2,3-aminomutase activity
Vgang_RS01630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Vgang_RS01640	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Vgang_RS01645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Vgang_RS01650	COG1053	succinate dehydrogenase
Vgang_RS01670	COG0688	phosphatidylethanolamine metabolic process
Vgang_RS01675	COG1162	GTPase activity
Vgang_RS01700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Vgang_RS01705	COG0802	atpase or kinase
Vgang_RS01710	COG0860	N-Acetylmuramoyl-L-alanine amidase
Vgang_RS01715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Vgang_RS01720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Vgang_RS01730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Vgang_RS01735	COG0330	HflC and HflK could
Vgang_RS01740	COG0330	HflC and HflK could
Vgang_RS01745	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Vgang_RS01750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vgang_RS01755	COG1017	nitric oxide dioxygenase activity
Vgang_RS01755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vgang_RS01765	COG0557	exoribonuclease II activity
Vgang_RS01770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vgang_RS01780	COG2965	DNA replication, synthesis of RNA primer
Vgang_RS01790	COG0359	binds to the 23S rRNA
Vgang_RS01805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vgang_RS01820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Vgang_RS01825	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Vgang_RS01830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vgang_RS01835	COG0163	prenyltransferase activity
Vgang_RS01840	COG4143	(ABC) transporter
Vgang_RS01845	COG1178	ABC-type Fe3 transport system permease component
Vgang_RS01850	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Vgang_RS01860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Vgang_RS01865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Vgang_RS01870	COG0564	pseudouridine synthase activity
Vgang_RS01875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vgang_RS01885	COG1438	arginine binding
Vgang_RS01890	COG0039	L-malate dehydrogenase activity
Vgang_RS01895	COG0142	geranyltranstransferase activity
Vgang_RS01910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vgang_RS01915	COG2966	Psort location CytoplasmicMembrane, score
Vgang_RS01920	COG3610	response to peptide
Vgang_RS01945	COG0653	protein targeting
Vgang_RS01950	COG0494	nUDIX hydrolase
Vgang_RS01960	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Vgang_RS01965	COG0237	dephospho-CoA kinase activity
Vgang_RS01975	COG1459	type II secretion system
Vgang_RS01980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vgang_RS01990	COG0157	Belongs to the NadC ModD family
Vgang_RS01995	COG3023	N-Acetylmuramoyl-L-alanine amidase
Vgang_RS02000	COG2186	Transcriptional regulator
Vgang_RS02005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Vgang_RS02010	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vgang_RS02015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vgang_RS02020	COG0693	protein deglycase activity
Vgang_RS02045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Vgang_RS02050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vgang_RS02055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Vgang_RS02060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Vgang_RS02065	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Vgang_RS02075	COG1215	transferase activity, transferring glycosyl groups
Vgang_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
Vgang_RS02100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vgang_RS02130	COG1216	Glycosyl transferase, family 2
Vgang_RS02140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Vgang_RS02150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vgang_RS02155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vgang_RS02180	COG0066	3-isopropylmalate dehydratase activity
Vgang_RS02190	COG0473	3-isopropylmalate dehydrogenase activity
Vgang_RS02210	COG0583	DNA-binding transcription factor activity
Vgang_RS02215	COG0028	Belongs to the TPP enzyme family
Vgang_RS02220	COG0440	acetolactate synthase activity
Vgang_RS02230	COG1349	DNA-binding transcription factor activity
Vgang_RS02240	COG4991	sh3 domain protein
Vgang_RS02245	COG0306	phosphate transporter
Vgang_RS02250	COG1392	Phosphate transport regulator
Vgang_RS02255	COG3025	triphosphatase activity
Vgang_RS02260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vgang_RS02265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Vgang_RS02270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Vgang_RS02270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Vgang_RS02275	COG1538	Outer membrane efflux protein
Vgang_RS02280	COG0494	nUDIX hydrolase
Vgang_RS02285	COG3151	Protein conserved in bacteria
Vgang_RS02295	COG3150	esterase
Vgang_RS02300	COG0187	DNA topoisomerase II activity
Vgang_RS02315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vgang_RS02320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vgang_RS02325	COG3105	Protein conserved in bacteria
Vgang_RS02330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Vgang_RS02340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Vgang_RS02345	COG0723	plastoquinol--plastocyanin reductase activity
Vgang_RS02350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Vgang_RS02355	COG2857	Cytochrome c1
Vgang_RS02360	COG0625	glutathione transferase activity
Vgang_RS02365	COG2969	positive regulation of protein catabolic process
Vgang_RS02375	COG2860	membrane
Vgang_RS02385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Vgang_RS02400	COG0070	glutamate synthase
Vgang_RS02400	COG0069	glutamate synthase activity
Vgang_RS02400	COG0067	glutamate synthase
Vgang_RS02410	COG2198	Histidine kinase
Vgang_RS02410	COG5002	protein histidine kinase activity
Vgang_RS02410	COG0784	Response regulator, receiver
Vgang_RS02415	COG0745	RESPONSE REGULATOR receiver
Vgang_RS02420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vgang_RS02430	COG0083	homoserine kinase activity
Vgang_RS02435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vgang_RS02440	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
Vgang_RS02445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Vgang_RS02460	COG1115	amino acid carrier protein
Vgang_RS02465	COG3022	response to hydroperoxide
Vgang_RS02470	COG0513	Belongs to the DEAD box helicase family
Vgang_RS02490	COG4974	Belongs to the 'phage' integrase family
Vgang_RS02495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vgang_RS02500	COG3097	Belongs to the UPF0267 family
Vgang_RS02505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Vgang_RS02515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Vgang_RS02535	COG0667	Aldo Keto reductase
Vgang_RS02550	COG0494	nUDIX hydrolase
Vgang_RS02555	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
Vgang_RS02565	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Vgang_RS02570	COG0583	DNA-binding transcription factor activity
Vgang_RS02575	COG0640	Transcriptional regulator
Vgang_RS02580	COG0268	Binds directly to 16S ribosomal RNA
Vgang_RS02585	COG0728	peptidoglycan biosynthetic process
Vgang_RS02590	COG0196	riboflavin kinase activity
Vgang_RS02595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vgang_RS02600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Vgang_RS02605	COG1047	Peptidyl-prolyl cis-trans
Vgang_RS02610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Vgang_RS02635	COG1966	Carbon starvation protein
Vgang_RS02655	COG0569	domain protein
Vgang_RS02655	COG0189	ligase activity
Vgang_RS02660	COG3279	Response regulator of the LytR AlgR family
Vgang_RS02665	COG3275	phosphorelay sensor kinase activity
Vgang_RS02675	COG1605	Chorismate mutase
Vgang_RS02675	COG0287	Prephenate dehydrogenase
Vgang_RS02680	COG0739	heme binding
Vgang_RS02685	COG0488	(ABC) transporter
Vgang_RS02695	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
Vgang_RS02705	COG1605	Chorismate mutase
Vgang_RS02705	COG0077	Prephenate dehydratase
Vgang_RS02710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Vgang_RS02715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vgang_RS02720	COG0564	pseudouridine synthase activity
Vgang_RS02730	COG0542	response to heat
Vgang_RS02790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vgang_RS02795	COG0826	peptidase U32
Vgang_RS02800	COG2974	May be involved in recombination
Vgang_RS02805	COG0745	RESPONSE REGULATOR receiver
Vgang_RS02810	COG5002	protein histidine kinase activity
Vgang_RS02820	COG0248	Ppx GppA phosphatase
Vgang_RS02825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Vgang_RS02830	COG0573	inorganic phosphate transmembrane transporter activity
Vgang_RS02835	COG0573	inorganic phosphate transmembrane transporter activity
Vgang_RS02840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Vgang_RS02850	COG3142	Participates in the control of copper homeostasis
Vgang_RS02855	COG0450	alkyl hydroperoxide reductase
Vgang_RS02860	COG0583	DNA-binding transcription factor activity
Vgang_RS02865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Vgang_RS02875	COG1862	Preprotein translocase
Vgang_RS02880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vgang_RS02885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vgang_RS02890	COG0483	inositol monophosphate 1-phosphatase activity
Vgang_RS02905	COG1104	cysteine desulfurase activity
Vgang_RS02910	COG0822	iron-sulfur transferase activity
Vgang_RS02925	COG0443	Heat shock 70 kDa protein
Vgang_RS02930	COG0633	Ferredoxin
Vgang_RS02935	COG2975	iron-sulfur cluster assembly
Vgang_RS02940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Vgang_RS02945	COG0105	UTP biosynthetic process
Vgang_RS02960	COG1426	Protein conserved in bacteria
Vgang_RS02965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Vgang_RS02970	COG0124	histidyl-tRNA synthetase
Vgang_RS02975	COG2976	Protein conserved in bacteria
Vgang_RS02980	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vgang_RS02985	COG1160	GTP binding
Vgang_RS02995	COG1570	exodeoxyribonuclease VII activity
Vgang_RS03000	COG0516	GMP reductase activity
Vgang_RS03000	COG0517	IMP dehydrogenase activity
Vgang_RS03005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Vgang_RS03005	COG0519	Catalyzes the synthesis of GMP from XMP
Vgang_RS03010	COG0582	viral genome integration into host DNA
Vgang_RS03130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vgang_RS03150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Vgang_RS03160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vgang_RS03165	COG0673	inositol 2-dehydrogenase activity
Vgang_RS03175	COG0668	transmembrane transport
Vgang_RS03180	COG0583	DNA-binding transcription factor activity
Vgang_RS03185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Vgang_RS03195	COG3385	transposase activity
Vgang_RS03200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Vgang_RS03205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Vgang_RS03210	COG1845	cytochrome c oxidase, subunit III
Vgang_RS03215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Vgang_RS03220	COG0109	protoheme IX farnesyltransferase activity
Vgang_RS03240	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Vgang_RS03280	COG2867	negative regulation of translational initiation
Vgang_RS03285	COG2914	Belongs to the UPF0125 (RnfH) family
Vgang_RS03290	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vgang_RS03295	COG0497	DNA recombination
Vgang_RS03300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vgang_RS03305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Vgang_RS03310	COG0667	Aldo Keto reductase
Vgang_RS03315	COG0443	Heat shock 70 kDa protein
Vgang_RS03320	COG0484	heat shock protein binding
Vgang_RS03365	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Vgang_RS03370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Vgang_RS03370	COG0047	phosphoribosylformylglycinamidine synthase activity
Vgang_RS03380	COG0514	ATP-dependent DNA helicase (RecQ)
Vgang_RS03395	COG3325	Belongs to the glycosyl hydrolase 18 family
Vgang_RS03395	COG3469	chitinase activity
Vgang_RS03415	COG0442	prolyl-tRNA aminoacylation
Vgang_RS03420	COG1720	tRNA m6t6A37 methyltransferase activity
Vgang_RS03425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Vgang_RS03440	COG1464	Belongs to the NlpA lipoprotein family
Vgang_RS03445	COG2011	ABC-type metal ion transport system permease component
Vgang_RS03450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Vgang_RS03455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Vgang_RS03460	COG4174	ABC transporter (Permease)
Vgang_RS03465	COG4239	(ABC) transporter, permease
Vgang_RS03470	COG0747	negative chemotaxis
Vgang_RS03475	COG0444	Belongs to the ABC transporter superfamily
Vgang_RS03480	COG4608	Belongs to the ABC transporter superfamily
Vgang_RS03505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Vgang_RS03510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vgang_RS03510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vgang_RS03530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vgang_RS03535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Vgang_RS03540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Vgang_RS03550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Vgang_RS03555	COG0142	geranyltranstransferase activity
Vgang_RS03565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vgang_RS03565	COG0301	tRNA thio-modification
Vgang_RS03570	COG0583	DNA-binding transcription factor activity
Vgang_RS03580	COG2363	Small membrane protein
Vgang_RS03585	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Vgang_RS03595	COG1611	Belongs to the LOG family
Vgang_RS03605	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vgang_RS03605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vgang_RS03615	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
Vgang_RS03620	COG1671	Belongs to the UPF0178 family
Vgang_RS03640	COG3098	single-species biofilm formation
Vgang_RS03645	COG0564	pseudouridine synthase activity
Vgang_RS03660	COG0024	Methionine aminopeptidase
Vgang_RS03670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Vgang_RS03685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Vgang_RS03690	COG0575	Belongs to the CDS family
Vgang_RS03695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Vgang_RS03700	COG0750	zinc metalloprotease
Vgang_RS03710	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Vgang_RS03715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vgang_RS03725	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vgang_RS03740	COG0587	DNA-directed DNA polymerase activity
Vgang_RS03745	COG0825	malonyl-CoA metabolic process
Vgang_RS03750	COG0037	tRNA processing
Vgang_RS03755	COG0347	Belongs to the P(II) protein family
Vgang_RS03760	COG3021	interspecies interaction between organisms
Vgang_RS03765	COG0741	lytic transglycosylase activity
Vgang_RS03765	COG1388	LysM domain
Vgang_RS03770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vgang_RS03775	COG2226	methyltransferase
Vgang_RS03785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Vgang_RS03790	COG1960	acyl-CoA dehydrogenase activity
Vgang_RS03795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Vgang_RS03800	COG0121	glutamine amidotransferase
Vgang_RS03805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Vgang_RS03810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Vgang_RS03815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Vgang_RS03825	COG1979	alcohol dehydrogenase
Vgang_RS03830	COG2130	NADP-dependent
Vgang_RS03835	COG0583	DNA-binding transcription factor activity
Vgang_RS03850	COG1393	Belongs to the ArsC family
Vgang_RS03855	COG4783	chaperone-mediated protein folding
Vgang_RS03875	COG2963	transposase activity
Vgang_RS03880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Vgang_RS03890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vgang_RS03895	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Vgang_RS03905	COG1876	peptidase activity
Vgang_RS03915	COG1393	Belongs to the ArsC family
Vgang_RS03935	COG2837	iron assimilation
Vgang_RS03940	COG2190	(PTS) system
Vgang_RS03945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vgang_RS03950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vgang_RS03960	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Vgang_RS03965	COG3115	cell septum assembly
Vgang_RS03985	COG0789	Transcriptional regulator
Vgang_RS03990	COG3118	belongs to the thioredoxin family
Vgang_RS03995	COG1090	epimerase
Vgang_RS04000	COG0622	Phosphoesterase
Vgang_RS04015	COG3710	Transcriptional regulator
Vgang_RS04020	COG0326	Molecular chaperone. Has ATPase activity
Vgang_RS04030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Vgang_RS04035	COG3104	oligopeptide transport
Vgang_RS04045	COG0367	asparagine synthase
Vgang_RS04055	COG1846	Transcriptional regulator
Vgang_RS04055	COG1940	carbohydrate kinase activity
Vgang_RS04060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Vgang_RS04065	COG0363	glucosamine-6-phosphate deaminase activity
Vgang_RS04070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vgang_RS04070	COG2190	(PTS) system
Vgang_RS04070	COG1263	PTS System
Vgang_RS04075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vgang_RS04080	COG0735	belongs to the Fur family
Vgang_RS04085	COG0716	FMN binding
Vgang_RS04095	COG0596	Alpha beta hydrolase
Vgang_RS04100	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Vgang_RS04105	COG0033	Phosphoglucomutase
Vgang_RS04115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Vgang_RS04130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Vgang_RS04135	COG1053	succinate dehydrogenase
Vgang_RS04145	COG0567	Dehydrogenase, E1 component
Vgang_RS04150	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vgang_RS04170	COG0366	Alpha amylase catalytic
Vgang_RS04175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Vgang_RS04180	COG1121	(ABC) transporter
Vgang_RS04185	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Vgang_RS04190	COG0739	heme binding
Vgang_RS04200	COG1918	ferrous iron import across plasma membrane
Vgang_RS04205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Vgang_RS04215	COG0018	arginyl-trna synthetase
Vgang_RS04220	COG3102	Protein conserved in bacteria
Vgang_RS04225	COG0788	formyltetrahydrofolate deformylase activity
Vgang_RS04230	COG1199	ATP-dependent helicase activity
Vgang_RS04235	COG1214	PFAM Peptidase M22, glycoprotease
Vgang_RS04245	COG0596	Alpha beta hydrolase
Vgang_RS04250	COG0318	PFAM AMP-dependent synthetase and ligase
Vgang_RS04255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Vgang_RS04265	COG2894	cell division
Vgang_RS04275	COG3100	YcgL domain-containing protein
Vgang_RS04280	COG2951	lytic endotransglycosylase activity
Vgang_RS04285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vgang_RS04300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Vgang_RS04320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vgang_RS04325	COG0583	DNA-binding transcription factor activity
Vgang_RS04330	COG0814	amino acid
Vgang_RS04355	COG1653	transport
Vgang_RS04360	COG1175	transmembrane transport
Vgang_RS04365	COG0395	ABC-type sugar transport system, permease component
Vgang_RS04370	COG3842	ATPase activity
Vgang_RS04385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Vgang_RS04390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Vgang_RS04395	COG0776	regulation of translation
Vgang_RS04400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vgang_RS04405	COG1555	photosystem II stabilization
Vgang_RS04420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Vgang_RS04425	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Vgang_RS04430	COG0436	Aminotransferase
Vgang_RS04435	COG1169	isochorismate synthase
Vgang_RS04440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Vgang_RS04445	COG2267	carboxylic ester hydrolase activity
Vgang_RS04465	COG2855	membrane
Vgang_RS04480	COG0280	phosphate acetyltransferase
Vgang_RS04480	COG0857	belongs to the CobB CobQ family
Vgang_RS04485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Vgang_RS04490	COG3092	negative regulation of chromosome organization
Vgang_RS04500	COG4120	Belongs to the binding-protein-dependent transport system permease family
Vgang_RS04505	COG1122	ATPase activity
Vgang_RS04510	COG3706	GGDEF domain
Vgang_RS04515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Vgang_RS04520	COG0653	protein targeting
Vgang_RS04525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Vgang_RS04530	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vgang_RS04535	COG2186	Transcriptional regulator
Vgang_RS04555	COG0489	protein tyrosine kinase activity
Vgang_RS04560	COG0572	uridine kinase
Vgang_RS04565	COG0717	Belongs to the dCTP deaminase family
Vgang_RS04570	COG2982	Protein involved in outer membrane biogenesis
Vgang_RS04575	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Vgang_RS04580	COG0659	secondary active sulfate transmembrane transporter activity
Vgang_RS04585	COG1530	ribonuclease E activity
Vgang_RS04590	COG0564	pseudouridine synthase activity
Vgang_RS04595	COG0424	maF-like protein
Vgang_RS04600	COG1399	metal-binding, possibly nucleic acid-binding protein
Vgang_RS04605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Vgang_RS04615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vgang_RS04635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vgang_RS04645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Vgang_RS04650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Vgang_RS04660	COG0084	hydrolase, TatD family'
Vgang_RS04665	COG2190	(PTS) system
Vgang_RS04665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vgang_RS04665	COG1263	PTS System
Vgang_RS04685	COG0733	neurotransmitter:sodium symporter activity
Vgang_RS04690	COG4667	esterase of the alpha-beta hydrolase superfamily
Vgang_RS04700	COG0469	pyruvate kinase activity
Vgang_RS04705	COG1940	carbohydrate kinase activity
Vgang_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
Vgang_RS04715	COG0616	signal peptide processing
Vgang_RS04720	COG2116	formate transmembrane transporter activity
Vgang_RS04730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vgang_RS04750	COG0686	Belongs to the AlaDH PNT family
Vgang_RS04755	COG1522	sequence-specific DNA binding
Vgang_RS04760	COG1674	ftsk spoiiie
Vgang_RS04765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Vgang_RS04770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Vgang_RS04775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Vgang_RS04785	COG0189	ligase activity
Vgang_RS04785	COG4067	protein conserved in archaea
Vgang_RS04795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Vgang_RS04800	COG0156	8-amino-7-oxononanoate synthase activity
Vgang_RS04810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Vgang_RS04820	COG0501	Belongs to the peptidase M48B family
Vgang_RS04835	COG0730	response to heat
Vgang_RS04840	COG1199	ATP-dependent helicase activity
Vgang_RS04850	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Vgang_RS04855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vgang_RS04865	COG1757	Na H antiporter
Vgang_RS04870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Vgang_RS04880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vgang_RS04885	COG0131	Imidazoleglycerol-phosphate dehydratase
Vgang_RS04885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Vgang_RS04890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Vgang_RS04895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Vgang_RS04905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vgang_RS04905	COG0140	phosphoribosyl-ATP diphosphatase activity
Vgang_RS04915	COG1566	PFAM secretion protein HlyD family protein
Vgang_RS04925	COG3012	SEC-C Motif Domain Protein
Vgang_RS04930	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Vgang_RS04935	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vgang_RS04940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Vgang_RS04945	COG0215	cysteine-tRNA ligase activity
Vgang_RS04950	COG1435	thymidine kinase activity
Vgang_RS04965	COG0189	ligase activity
Vgang_RS04965	COG4067	protein conserved in archaea
Vgang_RS04970	COG0500	methyltransferase
Vgang_RS04975	COG4106	trans-aconitate 2-methyltransferase activity
Vgang_RS04985	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Vgang_RS04990	COG0632	four-way junction helicase activity
Vgang_RS05000	COG1271	oxidase subunit
Vgang_RS05005	COG1294	oxidase, subunit
Vgang_RS05010	COG4890	Cyd operon protein YbgT
Vgang_RS05020	COG0824	Thioesterase
Vgang_RS05025	COG0811	peptide transport
Vgang_RS05030	COG0848	biopolymer transport protein
Vgang_RS05040	COG0823	Involved in the tonB-independent uptake of proteins
Vgang_RS05045	COG2885	chlorophyll binding
Vgang_RS05050	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Vgang_RS05065	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Vgang_RS05070	COG0372	Belongs to the citrate synthase family
Vgang_RS05080	COG2828	Protein conserved in bacteria
Vgang_RS05085	COG0657	acetylesterase activity
Vgang_RS05085	COG2755	lipolytic protein G-D-S-L family
Vgang_RS05090	COG3706	GGDEF domain
Vgang_RS05095	COG0668	transmembrane transport
Vgang_RS05100	COG1166	arginine decarboxylase activity
Vgang_RS05115	COG1032	radical SAM domain protein
Vgang_RS05120	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Vgang_RS05135	COG0583	DNA-binding transcription factor activity
Vgang_RS05140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vgang_RS05155	COG3313	Fe-S protein
Vgang_RS05165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Vgang_RS05170	COG1609	Transcriptional regulator
Vgang_RS05175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Vgang_RS05180	COG3265	gluconokinase activity
Vgang_RS05195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Vgang_RS05200	COG1061	Type III restriction enzyme res subunit
Vgang_RS05205	COG2067	long-chain fatty acid transport protein
Vgang_RS05215	COG2814	Major facilitator Superfamily
Vgang_RS05240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vgang_RS05250	COG1960	acyl-CoA dehydrogenase activity
Vgang_RS05255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Vgang_RS05265	COG2985	domain, Protein
Vgang_RS05265	COG3273	potassium ion transport
Vgang_RS05275	COG1737	Transcriptional regulator
Vgang_RS05280	COG0076	glutamate decarboxylase activity
Vgang_RS05290	COG2431	L-lysine efflux transmembrane transporter activity
Vgang_RS05295	COG3070	regulator of competence-specific genes
Vgang_RS05310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Vgang_RS05315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Vgang_RS05320	COG4988	ABC transporter
Vgang_RS05325	COG0492	ferredoxin-NADP+ reductase activity
Vgang_RS05340	COG2949	membrane
Vgang_RS05345	COG0281	malic enzyme
Vgang_RS05370	COG1942	4-Oxalocrotonate Tautomerase
Vgang_RS05390	COG2133	pyrroloquinoline quinone binding
Vgang_RS05400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vgang_RS05400	COG0072	phenylalanine-tRNA ligase activity
Vgang_RS05415	COG0776	regulation of translation
Vgang_RS05430	COG0295	cytidine deaminase activity
Vgang_RS05435	COG1346	cytolysis
Vgang_RS05445	COG2925	Exonuclease
Vgang_RS05460	COG1643	Atp-dependent helicase
Vgang_RS05480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vgang_RS05485	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Vgang_RS05490	COG1280	lysine exporter protein (LysE YggA)
Vgang_RS05505	COG1666	GTP binding
Vgang_RS05510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vgang_RS05545	COG3008	intermembrane lipid transfer
Vgang_RS05550	COG2995	paraquat-inducible protein a
Vgang_RS05555	COG1132	(ABC) transporter
Vgang_RS05560	COG1956	GAF domain-containing protein
Vgang_RS05565	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Vgang_RS05580	COG0308	aminopeptidase N
Vgang_RS05585	COG2902	Dehydrogenase
Vgang_RS05590	COG0167	dihydroorotate dehydrogenase activity
Vgang_RS05610	COG0488	(ABC) transporter
Vgang_RS05625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vgang_RS05630	COG1067	ATP-dependent peptidase activity
Vgang_RS05705	COG0534	Mate efflux family protein
Vgang_RS05710	COG0023	Translation Initiation Factor
Vgang_RS05720	COG1181	Belongs to the D-alanine--D-alanine ligase family
Vgang_RS05735	COG0583	DNA-binding transcription factor activity
Vgang_RS05740	COG1629	transport
Vgang_RS05740	COG4771	TonB-dependent receptor
Vgang_RS05745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Vgang_RS05775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vgang_RS05780	COG3118	belongs to the thioredoxin family
Vgang_RS05790	COG0602	queuosine metabolic process
Vgang_RS05795	COG0720	synthase
Vgang_RS05815	COG4533	DNA binding
Vgang_RS05825	COG2050	protein possibly involved in aromatic compounds catabolism
Vgang_RS05835	COG0748	coenzyme F420 binding
Vgang_RS05840	COG3721	Heme iron utilization protein
Vgang_RS05845	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Vgang_RS05850	COG0811	peptide transport
Vgang_RS05855	COG0848	biopolymer transport protein
Vgang_RS05865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vgang_RS05870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Vgang_RS05890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Vgang_RS05900	COG2353	YceI-like domain
Vgang_RS05905	COG3038	cytochrome b561
Vgang_RS05910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Vgang_RS05925	COG5001	Diguanylate cyclase
Vgang_RS05930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vgang_RS05950	COG0714	Associated with various cellular activities
Vgang_RS05960	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Vgang_RS05970	COG0513	Belongs to the DEAD box helicase family
Vgang_RS05975	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
Vgang_RS05985	COG0546	phosphoglycolate phosphatase activity
Vgang_RS06010	COG0545	Peptidyl-prolyl cis-trans isomerase
Vgang_RS06015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vgang_RS06030	COG0303	'Molybdopterin
Vgang_RS06035	COG0861	Integral membrane protein TerC family
Vgang_RS06040	COG0737	Belongs to the 5'-nucleotidase family
Vgang_RS06045	COG3593	DNA synthesis involved in DNA repair
Vgang_RS06050	COG0561	phosphatase activity
Vgang_RS06060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vgang_RS06070	COG2207	Transcriptional regulator
Vgang_RS06075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vgang_RS06075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vgang_RS06075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vgang_RS06090	COG0488	(ABC) transporter
Vgang_RS06100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Vgang_RS06105	COG0513	Belongs to the DEAD box helicase family
Vgang_RS06110	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
Vgang_RS06120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Vgang_RS06135	COG2824	Alkylphosphonate utilization operon protein PhnA
Vgang_RS06160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vgang_RS06170	COG3768	UPF0283 membrane protein
Vgang_RS06175	COG3106	COG3106 Predicted ATPase
Vgang_RS06190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vgang_RS06195	COG0494	nUDIX hydrolase
Vgang_RS06200	COG0814	amino acid
Vgang_RS06205	COG1760	l-serine dehydratase
Vgang_RS06210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vgang_RS06215	COG0251	oxidation-reduction process
Vgang_RS06225	COG0017	Asparaginyl-tRNA synthetase
Vgang_RS06230	COG2807	transmembrane transport
Vgang_RS06245	COG1448	Aminotransferase
Vgang_RS06250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vgang_RS06265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vgang_RS06280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vgang_RS06315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vgang_RS06335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vgang_RS06340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vgang_RS06390	COG1022	Amp-dependent synthetase and ligase
Vgang_RS06425	COG0322	excinuclease ABC activity
Vgang_RS06430	COG2197	response regulator
Vgang_RS06435	COG0417	DNA replication proofreading
Vgang_RS06460	COG0009	L-threonylcarbamoyladenylate synthase
Vgang_RS06465	COG0613	PHP domain protein
Vgang_RS06475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vgang_RS06480	COG0512	Glutamine amidotransferase of anthranilate synthase
Vgang_RS06485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vgang_RS06490	COG0134	indole-3-glycerol-phosphate synthase activity
Vgang_RS06490	COG0135	phosphoribosylanthranilate isomerase activity
Vgang_RS06495	COG0133	tryptophan synthase activity
Vgang_RS06500	COG0159	tryptophan synthase activity
Vgang_RS06515	COG2350	Protein conserved in bacteria
Vgang_RS06530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vgang_RS06535	COG0564	pseudouridine synthase activity
Vgang_RS06540	COG0733	neurotransmitter:sodium symporter activity
Vgang_RS06550	COG0626	cystathionine gamma-synthase activity
Vgang_RS06565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vgang_RS06570	COG2818	Glycosylase
Vgang_RS06585	COG1842	Phage shock protein A
Vgang_RS06590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Vgang_RS06600	COG4168	peptide transport system, permease
Vgang_RS06615	COG4172	Belongs to the ABC transporter superfamily
Vgang_RS06630	COG0471	metal ion transport
Vgang_RS06640	COG1227	inorganic diphosphatase activity
Vgang_RS06665	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
Vgang_RS06670	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
Vgang_RS06675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vgang_RS06680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Vgang_RS06685	COG1609	Transcriptional regulator
Vgang_RS06690	COG4134	Bacterial extracellular solute-binding protein
Vgang_RS06695	COG4135	transport system, permease component
Vgang_RS06700	COG4136	ATPase activity
Vgang_RS06705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Vgang_RS06715	COG0596	Alpha beta hydrolase
Vgang_RS06770	COG1715	Restriction endonuclease
Vgang_RS06900	COG2003	Belongs to the UPF0758 family
Vgang_RS06905	COG0730	response to heat
Vgang_RS06910	COG2084	Dehydrogenase
Vgang_RS06920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vgang_RS06940	COG4735	regulation of single-species biofilm formation
Vgang_RS06965	COG0582	viral genome integration into host DNA
Vgang_RS06990	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Vgang_RS06995	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Vgang_RS07000	COG0776	regulation of translation
Vgang_RS07005	COG0539	negative regulation of cytoplasmic translation
Vgang_RS07015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Vgang_RS07025	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Vgang_RS07030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Vgang_RS07035	COG0542	response to heat
Vgang_RS07040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Vgang_RS07045	COG1278	Cold shock
Vgang_RS07055	COG1187	pseudouridine synthase activity
Vgang_RS07065	COG2915	High frequency lysogenization protein hflD homolog
Vgang_RS07070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Vgang_RS07075	COG2850	peptidyl-arginine hydroxylation
Vgang_RS07080	COG0708	Exodeoxyribonuclease III
Vgang_RS07085	COG4160	amino acid transport
Vgang_RS07090	COG4215	(ABC) transporter
Vgang_RS07105	COG1882	Formate acetyltransferase
Vgang_RS07110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vgang_RS07120	COG2766	serine protein kinase
Vgang_RS07130	COG2719	SpoVR family
Vgang_RS07165	COG3547	Transposase (IS116 IS110 IS902 family)
Vgang_RS07185	COG2835	tetraacyldisaccharide 4'-kinase activity
Vgang_RS07190	COG1663	tetraacyldisaccharide 4'-kinase activity
Vgang_RS07195	COG1132	(ABC) transporter
Vgang_RS07200	COG2333	competence protein COMEC
Vgang_RS07200	COG0658	competence protein
Vgang_RS07210	COG4591	ABC-type transport system involved in lipoprotein release permease component
Vgang_RS07215	COG1136	(ABC) transporter
Vgang_RS07220	COG4591	ABC-type transport system involved in lipoprotein release permease component
Vgang_RS07225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Vgang_RS07240	COG1252	NADH dehydrogenase
Vgang_RS07245	COG3150	esterase
Vgang_RS07270	COG0537	adenosine 5'-monophosphoramidase activity
Vgang_RS07285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Vgang_RS07285	COG0617	tRNA 3'-terminal CCA addition
Vgang_RS07285	COG0517	IMP dehydrogenase activity
Vgang_RS07290	COG3153	acetyltransferase
Vgang_RS07290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vgang_RS07315	COG0330	HflC and HflK could
Vgang_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
Vgang_RS07330	COG0583	DNA-binding transcription factor activity
Vgang_RS07335	COG1064	alcohol dehydrogenase
Vgang_RS07345	COG2273	Hydrolase Family 16
Vgang_RS07350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vgang_RS07380	COG1946	Acyl-CoA thioesterase
Vgang_RS07385	COG1522	sequence-specific DNA binding
Vgang_RS07400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vgang_RS07440	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Vgang_RS07450	COG0435	Glutathione S-transferase
Vgang_RS07465	COG2723	6-phospho-beta-galactosidase activity
Vgang_RS07470	COG1609	Transcriptional regulator
Vgang_RS07475	COG1447	Phosphotransferase system cellobiose-specific component IIA
Vgang_RS07480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Vgang_RS07480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Vgang_RS07485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Vgang_RS07490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Vgang_RS07495	COG1940	carbohydrate kinase activity
Vgang_RS07510	COG1609	Transcriptional regulator
Vgang_RS07525	COG0395	ABC-type sugar transport system, permease component
Vgang_RS07530	COG3842	ATPase activity
Vgang_RS07535	COG1609	Transcriptional regulator
Vgang_RS07550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vgang_RS07555	COG0601	transmembrane transport
Vgang_RS07560	COG4166	transmembrane transport
Vgang_RS07575	COG0314	molybdopterin synthase activity
Vgang_RS07580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Vgang_RS07590	COG0521	Mo-molybdopterin cofactor biosynthetic process
Vgang_RS07600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Vgang_RS07605	COG0556	nucleotide-excision repair
Vgang_RS07615	COG4657	Part of a membrane complex involved in electron transport
Vgang_RS07625	COG4656	Part of a membrane complex involved in electron transport
Vgang_RS07630	COG4658	electron transport chain
Vgang_RS07635	COG4659	FMN binding
Vgang_RS07640	COG4660	Part of a membrane complex involved in electron transport
Vgang_RS07645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vgang_RS07650	COG0346	lactoylglutathione lyase activity
Vgang_RS07660	COG2056	Na+-H+ antiporter family
Vgang_RS07670	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Vgang_RS07685	COG1012	belongs to the aldehyde dehydrogenase family
Vgang_RS07685	COG1454	alcohol dehydrogenase
Vgang_RS07690	COG2095	MarC family integral membrane protein
Vgang_RS07695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vgang_RS07700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vgang_RS07705	COG3081	Nucleoid-associated protein
Vgang_RS07710	COG3082	Protein of unknown function (DUF1414)
Vgang_RS07715	COG3083	sulfuric ester hydrolase activity
Vgang_RS07730	COG1335	isochorismatase
Vgang_RS07755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vgang_RS07760	COG0778	Nitroreductase
Vgang_RS07765	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vgang_RS07765	COG1902	pentaerythritol trinitrate reductase activity
Vgang_RS07770	COG0616	signal peptide processing
Vgang_RS07775	COG0252	asparaginase activity
Vgang_RS07780	COG3139	Protein of unknown function (DUF1315)
Vgang_RS07785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vgang_RS07790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vgang_RS07800	COG2226	methyltransferase
Vgang_RS07805	COG2356	endonuclease I
Vgang_RS07815	COG2983	Belongs to the UPF0260 family
Vgang_RS07825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Vgang_RS07835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Vgang_RS07840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Vgang_RS07845	COG2832	Protein of unknown function (DUF454)
Vgang_RS07850	COG0745	RESPONSE REGULATOR receiver
Vgang_RS07855	COG0583	DNA-binding transcription factor activity
Vgang_RS07865	COG2963	transposase activity
Vgang_RS07870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vgang_RS07875	COG1286	toxin biosynthetic process
Vgang_RS07880	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Vgang_RS07885	COG0285	dihydrofolate synthase activity
Vgang_RS07895	COG0101	tRNA pseudouridine synthase activity
Vgang_RS07905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vgang_RS07910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vgang_RS07915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vgang_RS07920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vgang_RS07920	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Vgang_RS07935	COG3101	peptidyl-lysine hydroxylation
Vgang_RS07940	COG2860	membrane
Vgang_RS07945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Vgang_RS07950	COG2890	protein-(glutamine-N5) methyltransferase activity
Vgang_RS07955	COG2840	Smr protein MutS2
Vgang_RS07960	COG2062	phosphohistidine phosphatase, SixA
Vgang_RS07965	COG1025	Belongs to the peptidase M16 family
Vgang_RS07970	COG1024	Enoyl-CoA hydratase
Vgang_RS07970	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vgang_RS07975	COG0183	Belongs to the thiolase family
Vgang_RS07980	COG1595	DNA-templated transcription, initiation
Vgang_RS07990	COG2067	long-chain fatty acid transport protein
Vgang_RS08010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Vgang_RS08015	COG1138	Cytochrome C-type biogenesis protein
Vgang_RS08025	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vgang_RS08030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vgang_RS08035	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vgang_RS08040	COG4133	protoheme IX ABC transporter activity
Vgang_RS08045	COG1595	DNA-templated transcription, initiation
Vgang_RS08060	COG0415	Belongs to the DNA photolyase family
Vgang_RS08070	COG0300	oxidoreductase activity
Vgang_RS08075	COG1233	COG1233 Phytoene dehydrogenase and related
Vgang_RS08085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Vgang_RS08105	COG1132	(ABC) transporter
Vgang_RS08110	COG4774	siderophore transport
Vgang_RS08115	COG1120	ATPase activity
Vgang_RS08145	COG0443	Heat shock 70 kDa protein
Vgang_RS08175	COG0848	biopolymer transport protein
Vgang_RS08180	COG0811	peptide transport
Vgang_RS08185	COG0811	peptide transport
Vgang_RS08205	COG2608	mercury ion transmembrane transporter activity
Vgang_RS08205	COG2217	Heavy metal translocating P-type atpase
Vgang_RS08210	COG3735	TraB family
Vgang_RS08220	COG2814	Major facilitator Superfamily
Vgang_RS08235	COG2840	Smr protein MutS2
Vgang_RS08245	COG4115	mRNA cleavage
Vgang_RS08250	COG2161	toxin-antitoxin pair type II binding
Vgang_RS08255	COG0842	Transport permease protein
Vgang_RS08260	COG1131	(ABC) transporter
Vgang_RS08270	COG1309	transcriptional regulator
Vgang_RS08305	COG0737	Belongs to the 5'-nucleotidase family
Vgang_RS08310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Vgang_RS08315	COG2912	Transglutaminase-like superfamily
Vgang_RS08320	COG3094	Invasion gene expression up-regulator, SirB
Vgang_RS08325	COG2890	protein-(glutamine-N5) methyltransferase activity
Vgang_RS08330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Vgang_RS08335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Vgang_RS08340	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Vgang_RS08345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Vgang_RS08350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Vgang_RS08355	COG0193	aminoacyl-tRNA hydrolase activity
Vgang_RS08420	COG2706	6-phosphogluconolactonase activity
Vgang_RS08425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vgang_RS08435	COG1702	phosphate starvation-inducible protein PhoH
Vgang_RS08440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Vgang_RS08445	COG4535	Mg2 and Co2 transporter CorC
Vgang_RS08450	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Vgang_RS08455	COG0471	metal ion transport
Vgang_RS08465	COG3069	C4-dicarboxylate transmembrane transporter activity
Vgang_RS08470	COG2888	peptidyl-tyrosine sulfation
Vgang_RS08475	COG0495	leucyl-tRNA aminoacylation
Vgang_RS08485	COG1466	dna polymerase III delta subunit
Vgang_RS08490	COG0799	negative regulation of ribosome biogenesis
Vgang_RS08495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Vgang_RS08500	COG0768	penicillin binding
Vgang_RS08505	COG0772	Belongs to the SEDS family
Vgang_RS08510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Vgang_RS08515	COG1686	Belongs to the peptidase S11 family
Vgang_RS08530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Vgang_RS08535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Vgang_RS08540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Vgang_RS08550	COG1073	alpha beta
Vgang_RS08560	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vgang_RS08565	COG2252	PERMEase
Vgang_RS08570	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vgang_RS08575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vgang_RS08580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vgang_RS08590	COG4232	protein-disulfide reductase activity
Vgang_RS08595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Vgang_RS08600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Vgang_RS08610	COG3344	reverse transcriptase
Vgang_RS08645	COG3547	Transposase (IS116 IS110 IS902 family)
Vgang_RS08670	COG1280	lysine exporter protein (LysE YggA)
Vgang_RS08690	COG3547	Transposase (IS116 IS110 IS902 family)
Vgang_RS08710	COG1280	lysine exporter protein (LysE YggA)
Vgang_RS08745	COG1881	PFAM PEBP family protein
Vgang_RS08755	COG2226	methyltransferase
Vgang_RS08760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vgang_RS08765	COG0697	spore germination
Vgang_RS08830	COG1477	protein flavinylation
Vgang_RS08835	COG2871	sodium ion transport
Vgang_RS08840	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vgang_RS08850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vgang_RS08855	COG1805	sodium ion transport
Vgang_RS08860	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vgang_RS08865	COG0271	Belongs to the BolA IbaG family
Vgang_RS08870	COG2813	Specifically methylates the guanine in position
Vgang_RS08880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Vgang_RS08890	COG3248	Nucleoside-binding outer membrane protein
Vgang_RS08895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vgang_RS08900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vgang_RS08905	COG2166	iron-sulfur cluster assembly
Vgang_RS08910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Vgang_RS08915	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Vgang_RS08925	COG2731	YhcH YjgK YiaL family protein
Vgang_RS08930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Vgang_RS08935	COG1074	ATP-dependent DNA helicase activity
Vgang_RS08940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Vgang_RS08945	COG0583	DNA-binding transcription factor activity
Vgang_RS08950	COG3141	response to X-ray
Vgang_RS08955	COG1584	GPR1 FUN34 yaaH family protein
Vgang_RS08960	COG2171	N-acyltransferase activity
Vgang_RS08965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Vgang_RS08970	COG3835	regulator
Vgang_RS08975	COG2610	gluconate transmembrane transporter activity
Vgang_RS08980	COG1929	Belongs to the glycerate kinase type-1 family
Vgang_RS08990	COG1022	Amp-dependent synthetase and ligase
Vgang_RS08995	COG4628	conserved protein (DUF2132)
Vgang_RS09000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vgang_RS09005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Vgang_RS09010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Vgang_RS09015	COG0560	Phosphoserine phosphatase
Vgang_RS09025	COG0813	purine-nucleoside phosphorylase activity
Vgang_RS09035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Vgang_RS09040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Vgang_RS09045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Vgang_RS09050	COG0084	hydrolase, TatD family'
Vgang_RS09065	COG0456	acetyltransferase
Vgang_RS09075	COG3153	acetyltransferase
Vgang_RS09080	COG3154	lipid carrier protein
Vgang_RS09085	COG0826	peptidase U32
Vgang_RS09090	COG0826	peptidase U32
Vgang_RS09115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Vgang_RS09125	COG0195	Participates in both transcription termination and antitermination
Vgang_RS09130	COG0779	Required for maturation of 30S ribosomal subunits
Vgang_RS09145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Vgang_RS09155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Vgang_RS09160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vgang_RS09165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Vgang_RS09170	COG1534	Rna-binding protein
Vgang_RS09175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vgang_RS09180	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Vgang_RS09185	COG2027	D-alanyl-D-alanine carboxypeptidase
Vgang_RS09190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Vgang_RS09195	COG0505	Belongs to the CarA family
Vgang_RS09200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Vgang_RS09210	COG0336	Belongs to the RNA methyltransferase TrmD family
Vgang_RS09215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Vgang_RS09220	COG0228	four-way junction DNA binding
Vgang_RS09225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vgang_RS09230	COG4137	Cytochrome C assembly protein
Vgang_RS09235	COG4536	flavin adenine dinucleotide binding
Vgang_RS09240	COG1854	S-ribosylhomocysteine lyase activity
Vgang_RS09255	COG0612	Peptidase, M16
Vgang_RS09260	COG1238	metal cluster binding
Vgang_RS09310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vgang_RS09320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Vgang_RS09325	COG1546	Belongs to the CinA family
Vgang_RS09330	COG2358	TRAP transporter, solute receptor (TAXI family
Vgang_RS09340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Vgang_RS09345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Vgang_RS09350	COG4942	peptidase
Vgang_RS09350	COG1388	LysM domain
Vgang_RS09360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Vgang_RS09370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Vgang_RS09380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Vgang_RS09385	COG0148	phosphopyruvate hydratase activity
Vgang_RS09395	COG3956	TIGRFAM MazG family protein
Vgang_RS09400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vgang_RS09410	COG2205	protein histidine kinase activity
Vgang_RS09410	COG3850	Histidine kinase
Vgang_RS09410	COG4999	Histidine kinase
Vgang_RS09410	COG3437	response regulator, receiver
Vgang_RS09415	COG0736	holo-[acyl-carrier-protein] synthase activity
Vgang_RS09420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Vgang_RS09430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Vgang_RS09435	COG0571	ribonuclease III activity
Vgang_RS09440	COG0681	Belongs to the peptidase S26 family
Vgang_RS09445	COG0481	GTPase activity
Vgang_RS09450	COG3086	response to oxidative stress
Vgang_RS09460	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
Vgang_RS09465	COG1595	DNA-templated transcription, initiation
Vgang_RS09470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Vgang_RS09480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Vgang_RS09485	COG0354	folic acid binding
Vgang_RS09495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vgang_RS09500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vgang_RS09510	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Vgang_RS09520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Vgang_RS09525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Vgang_RS09530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vgang_RS09540	COG0668	transmembrane transport
Vgang_RS09545	COG0191	fructose-bisphosphate aldolase activity
Vgang_RS09550	COG0126	phosphoglycerate kinase activity
Vgang_RS09555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vgang_RS09560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Vgang_RS09565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Vgang_RS09575	COG3091	SprT-like family
Vgang_RS09585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Vgang_RS09590	COG0189	ligase activity
Vgang_RS09595	COG1678	Uncharacterized ACR, COG1678
Vgang_RS09620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Vgang_RS09625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Vgang_RS09630	COG0762	integral membrane protein
Vgang_RS09635	COG1872	DUF167
Vgang_RS09645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Vgang_RS09650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Vgang_RS09655	COG2066	Belongs to the glutaminase family
Vgang_RS09660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Vgang_RS09665	COG1194	a g-specific adenine glycosylase
Vgang_RS09675	COG0741	lytic transglycosylase activity
Vgang_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
Vgang_RS09745	COG0463	Glycosyl transferase, family 2
Vgang_RS09760	COG0795	lipopolysaccharide-transporting ATPase activity
Vgang_RS09765	COG0795	lipopolysaccharide-transporting ATPase activity
Vgang_RS09770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Vgang_RS09775	COG2927	DNA polymerase III (CHI subunit)
Vgang_RS09780	COG0525	valine-tRNA ligase activity
Vgang_RS09805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Vgang_RS09815	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Vgang_RS09820	COG0251	oxidation-reduction process
Vgang_RS09830	COG2199	diguanylate cyclase activity
Vgang_RS09835	COG2814	Major facilitator Superfamily
Vgang_RS09840	COG1566	PFAM secretion protein HlyD family protein
Vgang_RS09845	COG1846	Transcriptional regulator
Vgang_RS09850	COG0598	Magnesium transport protein CorA
Vgang_RS09855	COG0204	Acyl-transferase
Vgang_RS09860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Vgang_RS09865	COG5007	Belongs to the BolA IbaG family
Vgang_RS09875	COG2854	intermembrane phospholipid transfer
Vgang_RS09880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Vgang_RS09885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Vgang_RS09890	COG1127	ABC transporter
Vgang_RS09900	COG0517	IMP dehydrogenase activity
Vgang_RS09900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vgang_RS09905	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Vgang_RS09915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Vgang_RS09920	COG1137	ATPase activity
Vgang_RS09935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vgang_RS09940	COG1660	Displays ATPase and GTPase activities
Vgang_RS09945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vgang_RS09950	COG2239	Acts as a magnesium transporter
Vgang_RS09955	COG0312	modulator of DNA gyrase
Vgang_RS09960	COG3028	Belongs to the UPF0307 family
Vgang_RS09965	COG0312	modulator of DNA gyrase
Vgang_RS09970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vgang_RS09975	COG3164	Protein of unknown function
Vgang_RS09985	COG0424	maF-like protein
Vgang_RS09990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Vgang_RS09995	COG1792	Involved in formation and maintenance of cell shape
Vgang_RS10000	COG1077	Cell shape determining protein MreB Mrl
Vgang_RS10035	COG2199	diguanylate cyclase activity
Vgang_RS10035	COG2200	EAL domain
Vgang_RS10040	COG0629	single-stranded DNA binding
Vgang_RS10055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Vgang_RS10065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Vgang_RS10070	COG0527	aspartate kinase activity
Vgang_RS10075	COG0646	methionine synthase
Vgang_RS10075	COG1410	methionine synthase
Vgang_RS10090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Vgang_RS10095	COG0739	heme binding
Vgang_RS10105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vgang_RS10110	COG0628	permease
Vgang_RS10115	COG2813	Specifically methylates the guanine in position
Vgang_RS10120	COG0784	Response regulator, receiver
Vgang_RS10120	COG2205	protein histidine kinase activity
Vgang_RS10125	COG0747	negative chemotaxis
Vgang_RS10135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vgang_RS10140	COG0444	Belongs to the ABC transporter superfamily
Vgang_RS10145	COG4608	Belongs to the ABC transporter superfamily
Vgang_RS10155	COG2971	BadF BadG BcrA BcrD
Vgang_RS10170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vgang_RS10215	COG2814	Major facilitator Superfamily
Vgang_RS10220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Vgang_RS10225	COG1643	Atp-dependent helicase
Vgang_RS10230	COG1489	DNA binding
Vgang_RS10235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Vgang_RS10240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vgang_RS10250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Vgang_RS10255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Vgang_RS10260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Vgang_RS10265	COG0842	Transport permease protein
Vgang_RS10270	COG1131	(ABC) transporter
Vgang_RS10275	COG0288	reversible hydration of carbon dioxide
Vgang_RS10290	COG1049	propionate catabolic process, 2-methylcitrate cycle
Vgang_RS10295	COG1752	Esterase of the alpha-beta hydrolase superfamily
Vgang_RS10310	COG3267	Type II secretory pathway component ExeA
Vgang_RS10310	COG3409	Peptidoglycan-binding domain 1 protein
Vgang_RS10315	COG0617	tRNA 3'-terminal CCA addition
Vgang_RS10320	COG1968	undecaprenyl-diphosphatase activity
Vgang_RS10325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Vgang_RS10330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Vgang_RS10335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Vgang_RS10340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Vgang_RS10345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Vgang_RS10350	COG1610	YqeY-like protein
Vgang_RS10370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vgang_RS10375	COG1584	GPR1 FUN34 yaaH family protein
Vgang_RS10395	COG1566	PFAM secretion protein HlyD family protein
Vgang_RS10400	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Vgang_RS10405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Vgang_RS10410	COG0849	cell division
Vgang_RS10415	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Vgang_RS10420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vgang_RS10430	COG0772	Belongs to the SEDS family
Vgang_RS10435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Vgang_RS10445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Vgang_RS10455	COG0768	penicillin binding
Vgang_RS10460	COG3116	cell division
Vgang_RS10465	COG0275	rRNA processing
Vgang_RS10475	COG2706	6-phosphogluconolactonase activity
Vgang_RS10480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Vgang_RS10485	COG3107	peptidoglycan biosynthetic process
Vgang_RS10490	COG0792	nuclease activity
Vgang_RS10495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Vgang_RS10500	COG2823	Periplasmic or secreted lipoprotein
Vgang_RS10505	COG3842	ATPase activity
Vgang_RS10515	COG1840	ABC-type Fe3 transport system, periplasmic component
Vgang_RS10520	COG0004	ammonium transporteR
Vgang_RS10525	COG0347	Belongs to the P(II) protein family
Vgang_RS10530	COG3112	Uncharacterised protein family (UPF0231)
Vgang_RS10590	COG0175	sulfate reduction
Vgang_RS10595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vgang_RS10600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Vgang_RS10620	COG0735	belongs to the Fur family
Vgang_RS10630	COG2105	PFAM AIG2 family protein
Vgang_RS10635	COG2911	Protein conserved in bacteria
Vgang_RS10640	COG0729	surface antigen
Vgang_RS10645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vgang_RS10655	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Vgang_RS10665	COG0577	efflux transmembrane transporter activity
Vgang_RS10665	COG1136	(ABC) transporter
Vgang_RS10680	COG0529	Catalyzes the synthesis of activated sulfate
Vgang_RS10685	COG0471	metal ion transport
Vgang_RS10685	COG3273	potassium ion transport
Vgang_RS10690	COG2895	sulfate adenylyltransferase (ATP) activity
Vgang_RS10700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vgang_RS10700	COG1648	precorrin-2 dehydrogenase activity
Vgang_RS10705	COG2153	protein acetylation
Vgang_RS10710	COG3266	domain, Protein
Vgang_RS10710	COG3061	Opacity-associated protein A
Vgang_RS10715	COG0545	Peptidyl-prolyl cis-trans isomerase
Vgang_RS10725	COG0203	ribosomal protein L17
Vgang_RS10730	COG0202	RNA polymerase activity
Vgang_RS10745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Vgang_RS10750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Vgang_RS10755	COG0201	protein transport
Vgang_RS10760	COG0200	Binds to the 23S rRNA
Vgang_RS10765	COG1841	ribosomal large subunit assembly
Vgang_RS10780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Vgang_RS10785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Vgang_RS10790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Vgang_RS10795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Vgang_RS10820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Vgang_RS10825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Vgang_RS10830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Vgang_RS10835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Vgang_RS10840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vgang_RS10845	COG0089	rRNA binding
Vgang_RS10850	COG0088	Forms part of the polypeptide exit tunnel
Vgang_RS10855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Vgang_RS10860	COG0051	transcription antitermination factor activity, RNA binding
Vgang_RS10870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vgang_RS10890	COG2923	Belongs to the DsrF TusC family
Vgang_RS10895	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Vgang_RS10900	COG2964	Protein conserved in bacteria
Vgang_RS10905	COG0545	Peptidyl-prolyl cis-trans isomerase
Vgang_RS10910	COG2900	Belongs to the SlyX family
Vgang_RS10915	COG1047	Peptidyl-prolyl cis-trans
Vgang_RS10920	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
Vgang_RS10930	COG2249	NAD(P)H dehydrogenase (quinone) activity
Vgang_RS10935	COG0488	(ABC) transporter
Vgang_RS10945	COG3089	Belongs to the UPF0270 family
Vgang_RS10950	COG3954	Phosphoribulokinase
Vgang_RS10960	COG0814	amino acid
Vgang_RS10965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vgang_RS10970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Vgang_RS10975	COG1561	YicC-like family, N-terminal region
Vgang_RS10985	COG0243	molybdopterin cofactor binding
Vgang_RS10995	COG0194	GDP metabolic process
Vgang_RS11005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vgang_RS11015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Vgang_RS11030	COG0180	Tryptophanyl-tRNA synthetase
Vgang_RS11035	COG0546	phosphoglycolate phosphatase activity
Vgang_RS11040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Vgang_RS11045	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Vgang_RS11055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Vgang_RS11090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Vgang_RS11105	COG1566	PFAM secretion protein HlyD family protein
Vgang_RS11115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vgang_RS11115	COG0165	Argininosuccinate lyase
Vgang_RS11120	COG0137	argininosuccinate synthase activity
Vgang_RS11130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Vgang_RS11135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vgang_RS11140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Vgang_RS11145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Vgang_RS11150	COG0527	aspartate kinase activity
Vgang_RS11150	COG0460	homoserine dehydrogenase
Vgang_RS11155	COG0626	cystathionine gamma-synthase activity
Vgang_RS11160	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
Vgang_RS11165	COG0281	malic enzyme
Vgang_RS11170	COG0254	rRNA binding
Vgang_RS11175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Vgang_RS11180	COG1609	Transcriptional regulator
Vgang_RS11190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Vgang_RS11195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Vgang_RS11200	COG1575	Belongs to the MenA family. Type 1 subfamily
Vgang_RS11205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vgang_RS11210	COG3074	FtsZ-dependent cytokinesis
Vgang_RS11215	COG1494	fructose-1,6-bisphosphatase
Vgang_RS11225	COG0534	Mate efflux family protein
Vgang_RS11245	COG0205	6-phosphofructokinase activity
Vgang_RS11250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Vgang_RS11255	COG0210	DNA helicase
Vgang_RS11270	COG0471	metal ion transport
Vgang_RS11275	COG0783	Belongs to the Dps family
Vgang_RS11285	COG3604	Transcriptional regulator
Vgang_RS11300	COG2081	HI0933 family
Vgang_RS11310	COG1528	Iron-storage protein
Vgang_RS11315	COG0589	response to stress
Vgang_RS11330	COG4067	protein conserved in archaea
Vgang_RS11330	COG0189	ligase activity
Vgang_RS11335	COG0742	ribosomal rna small subunit methyltransferase
Vgang_RS11340	COG5002	protein histidine kinase activity
Vgang_RS11340	COG5001	Diguanylate cyclase
Vgang_RS11345	COG1522	sequence-specific DNA binding
Vgang_RS11360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Vgang_RS11375	COG0583	DNA-binding transcription factor activity
Vgang_RS11385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Vgang_RS11390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vgang_RS11405	COG0673	inositol 2-dehydrogenase activity
Vgang_RS11410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vgang_RS11415	COG0601	transmembrane transport
Vgang_RS11420	COG0747	negative chemotaxis
Vgang_RS11460	COG0210	DNA helicase
Vgang_RS11465	COG1309	transcriptional regulator
Vgang_RS11470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vgang_RS11475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vgang_RS11480	COG2960	long-chain fatty acid transporting porin activity
Vgang_RS11485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vgang_RS11490	COG0583	DNA-binding transcription factor activity
Vgang_RS11535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Vgang_RS11550	COG3118	belongs to the thioredoxin family
Vgang_RS11555	COG0513	Belongs to the DEAD box helicase family
Vgang_RS11560	COG0248	Ppx GppA phosphatase
Vgang_RS11570	COG0084	hydrolase, TatD family'
Vgang_RS11575	COG0805	protein transport
Vgang_RS11580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vgang_RS11585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vgang_RS11600	COG2226	methyltransferase
Vgang_RS11605	COG1322	Protein conserved in bacteria
Vgang_RS11610	COG0697	spore germination
Vgang_RS11620	COG0006	proline dipeptidase activity
Vgang_RS11630	COG2022	thiamine diphosphate biosynthetic process
Vgang_RS11640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vgang_RS11655	COG0038	chloride channel
Vgang_RS11700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vgang_RS11705	COG1739	Uncharacterized protein family UPF0029
Vgang_RS11710	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vgang_RS11710	COG1024	Enoyl-CoA hydratase
Vgang_RS11715	COG0183	Belongs to the thiolase family
Vgang_RS11730	COG1587	Uroporphyrinogen-III synthase
Vgang_RS11735	COG2959	enzyme of heme biosynthesis
Vgang_RS11740	COG3071	HemY protein
Vgang_RS11775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Vgang_RS11795	COG0009	L-threonylcarbamoyladenylate synthase
Vgang_RS11800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Vgang_RS11805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Vgang_RS11810	COG0551	DNA topoisomerase type I activity
Vgang_RS11815	COG2922	Belongs to the Smg family
Vgang_RS11820	COG0758	DNA mediated transformation
Vgang_RS11825	COG1652	LysM domain
Vgang_RS11835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Vgang_RS11840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vgang_RS11840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vgang_RS11845	COG0569	domain protein
Vgang_RS11850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vgang_RS11855	COG1272	protein, Hemolysin III
Vgang_RS11865	COG3084	Protein conserved in bacteria
Vgang_RS11875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Vgang_RS11880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vgang_RS11885	COG0204	Acyl-transferase
Vgang_RS11890	COG0606	chelatase, subunit chli
Vgang_RS11900	COG3978	acetolactate synthase activity
Vgang_RS11910	COG0129	dihydroxy-acid dehydratase activity
Vgang_RS11920	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Vgang_RS11925	COG0583	DNA-binding transcription factor activity
Vgang_RS11940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Vgang_RS11945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Vgang_RS11950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Vgang_RS11955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Vgang_RS11965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Vgang_RS11975	COG0356	it plays a direct role in the translocation of protons across the membrane
Vgang_RS11985	COG1475	DNA binding
Vgang_RS11990	COG1192	Involved in chromosome partitioning
Vgang_RS11995	COG0357	Ribosomal RNA small subunit methyltransferase G
Vgang_RS12000	COG0445	tRNA wobble uridine modification
Vgang_RS12025	COG0217	transcriptional regulatory protein
Vgang_RS12035	COG0534	Mate efflux family protein
Vgang_RS12045	COG1966	Carbon starvation protein
Vgang_RS12055	COG0003	Pfam Anion-transporting ATPase
Vgang_RS12065	COG0477	Major facilitator Superfamily
Vgang_RS12070	COG0786	glutamate:sodium symporter activity
Vgang_RS12080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Vgang_RS12085	COG4948	Mandelate Racemase Muconate Lactonizing
Vgang_RS12110	COG4175	Glycine betaine
Vgang_RS12130	COG1012	belongs to the aldehyde dehydrogenase family
Vgang_RS12135	COG1309	transcriptional regulator
Vgang_RS12140	COG4771	TonB-dependent receptor
Vgang_RS12145	COG0583	DNA-binding transcription factor activity
Vgang_RS12150	COG4604	ABC transporter, ATP-binding protein
Vgang_RS12155	COG4605	iron ion homeostasis
Vgang_RS12160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vgang_RS12170	COG1846	Transcriptional regulator
Vgang_RS12175	COG1764	response to oxidative stress
Vgang_RS12180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vgang_RS12185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vgang_RS12190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vgang_RS12200	COG1464	Belongs to the NlpA lipoprotein family
Vgang_RS12225	COG4667	esterase of the alpha-beta hydrolase superfamily
Vgang_RS12230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Vgang_RS12230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Vgang_RS12235	COG0509	glycine decarboxylation via glycine cleavage system
Vgang_RS12245	COG1115	amino acid carrier protein
Vgang_RS12250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Vgang_RS12295	COG1335	isochorismatase
Vgang_RS12305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vgang_RS12310	COG2084	Dehydrogenase
Vgang_RS12320	COG2824	Alkylphosphonate utilization operon protein PhnA
Vgang_RS12330	COG1011	Hydrolase
Vgang_RS12335	COG1846	Transcriptional regulator
Vgang_RS12340	COG2113	Glycine betaine
Vgang_RS12345	COG2113	Glycine betaine
Vgang_RS12350	COG4176	ABC-type proline glycine betaine transport system permease component
Vgang_RS12370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vgang_RS12380	COG0418	dihydroorotase activity
Vgang_RS12385	COG3217	Mosc domain protein beta barrel domain protein
Vgang_RS12385	COG0633	Ferredoxin
Vgang_RS12390	COG0561	phosphatase activity
Vgang_RS12400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vgang_RS12415	COG0513	Belongs to the DEAD box helicase family
Vgang_RS12425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vgang_RS12430	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Vgang_RS12445	COG0454	-acetyltransferase
Vgang_RS12460	COG0583	DNA-binding transcription factor activity
Vgang_RS12465	COG3384	dioxygenase
Vgang_RS12470	COG2259	Doxx family
Vgang_RS12475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vgang_RS12495	COG3842	ATPase activity
Vgang_RS12505	COG1177	transmembrane transport
Vgang_RS12525	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Vgang_RS12535	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vgang_RS12550	COG0235	Class ii aldolase
Vgang_RS12555	COG3254	rhamnose metabolic process
Vgang_RS12565	COG1070	Carbohydrate kinase
Vgang_RS12570	COG2084	Dehydrogenase
Vgang_RS12595	COG4948	Mandelate Racemase Muconate Lactonizing
Vgang_RS12600	COG2186	Transcriptional regulator
Vgang_RS12610	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Vgang_RS12615	COG0823	Involved in the tonB-independent uptake of proteins
Vgang_RS12620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vgang_RS12625	COG0800	Aldolase
Vgang_RS12630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vgang_RS12640	COG1917	Cupin 2, conserved barrel domain protein
Vgang_RS12645	COG1028	Short-chain dehydrogenase reductase Sdr
Vgang_RS12675	COG4677	pectinesterase activity
Vgang_RS12685	COG1175	transmembrane transport
Vgang_RS12690	COG0395	ABC-type sugar transport system, permease component
Vgang_RS12695	COG3842	ATPase activity
Vgang_RS12700	COG1653	transport
Vgang_RS12705	COG4677	pectinesterase activity
Vgang_RS12715	COG0534	Mate efflux family protein
Vgang_RS12725	COG0583	DNA-binding transcription factor activity
Vgang_RS12730	COG0730	response to heat
Vgang_RS12735	COG2200	EAL domain
Vgang_RS12750	COG1902	pentaerythritol trinitrate reductase activity
Vgang_RS12755	COG3722	fumarate hydratase activity
Vgang_RS12765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vgang_RS12765	COG2213	PTS system mannitol-specific
Vgang_RS12770	COG1741	Belongs to the pirin family
Vgang_RS12785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vgang_RS12800	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Vgang_RS12805	COG1714	RDD family
Vgang_RS12820	COG1069	ribulokinase activity
Vgang_RS12830	COG2160	L-arabinose isomerase activity
Vgang_RS12840	COG0561	phosphatase activity
Vgang_RS12860	COG1280	lysine exporter protein (LysE YggA)
Vgang_RS12865	COG0456	acetyltransferase
Vgang_RS12895	COG2017	converts alpha-aldose to the beta-anomer
Vgang_RS12900	COG3940	Belongs to the glycosyl hydrolase 43 family
Vgang_RS12905	COG2211	Major facilitator Superfamily
Vgang_RS12915	COG1242	4 iron, 4 sulfur cluster binding
Vgang_RS12935	COG0243	molybdopterin cofactor binding
Vgang_RS12940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vgang_RS12940	COG1648	precorrin-2 dehydrogenase activity
Vgang_RS12950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vgang_RS12955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vgang_RS12960	COG1116	anion transmembrane transporter activity
Vgang_RS12965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vgang_RS12965	COG2146	nitrite reductase [NAD(P)H] activity
Vgang_RS12975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Vgang_RS12985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Vgang_RS12990	COG0456	acetyltransferase
Vgang_RS12995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vgang_RS13000	COG0662	Cupin 2, conserved barrel domain protein
Vgang_RS13005	COG0527	aspartate kinase activity
Vgang_RS13030	COG1999	signal sequence binding
Vgang_RS13055	COG0531	amino acid
Vgang_RS13070	COG3123	guanosine phosphorylase activity
Vgang_RS13075	COG1335	isochorismatase
Vgang_RS13085	COG0189	ligase activity
Vgang_RS13090	COG4067	protein conserved in archaea
Vgang_RS13090	COG0189	ligase activity
Vgang_RS13105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Vgang_RS13110	COG4208	sulfate ABC transporter
Vgang_RS13115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Vgang_RS13120	COG4160	amino acid transport
Vgang_RS13125	COG4215	(ABC) transporter
Vgang_RS13130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vgang_RS13135	COG1126	abc transporter atp-binding protein
Vgang_RS13140	COG2252	PERMEase
Vgang_RS13145	COG2351	hydroxyisourate hydrolase activity
Vgang_RS13160	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Vgang_RS13190	COG4533	DNA binding
Vgang_RS13195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vgang_RS13200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vgang_RS13200	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Vgang_RS13200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vgang_RS13215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Vgang_RS13220	COG3005	denitrification pathway
Vgang_RS13225	COG0243	molybdopterin cofactor binding
Vgang_RS13235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vgang_RS13240	COG2814	Major facilitator Superfamily
Vgang_RS13250	COG0110	maltose O-acetyltransferase activity
Vgang_RS13255	COG0628	permease
Vgang_RS13275	COG3706	GGDEF domain
Vgang_RS13315	COG4989	oxidoreductase activity
Vgang_RS13320	COG4774	siderophore transport
Vgang_RS13325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Vgang_RS13330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vgang_RS13335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vgang_RS13340	COG1120	ATPase activity
Vgang_RS13345	COG2200	EAL domain
Vgang_RS13355	COG2721	sulfolactate sulfo-lyase activity
Vgang_RS13365	COG2186	Transcriptional regulator
Vgang_RS13370	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vgang_RS13380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vgang_RS13385	COG0246	Mannitol dehydrogenase
Vgang_RS13390	COG1312	Catalyzes the dehydration of D-mannonate
Vgang_RS13405	COG2814	Major facilitator Superfamily
Vgang_RS13425	COG2897	thiosulfate sulfurtransferase activity
Vgang_RS13440	COG0574	Belongs to the PEP-utilizing enzyme family
Vgang_RS13440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vgang_RS13445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Vgang_RS13460	COG3135	benzoate transporter
Vgang_RS13470	COG4264	IucA IucC family
Vgang_RS13490	COG1120	ATPase activity
Vgang_RS13495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Vgang_RS13500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vgang_RS13510	COG0006	proline dipeptidase activity
Vgang_RS13515	COG1522	sequence-specific DNA binding
Vgang_RS13520	COG1012	belongs to the aldehyde dehydrogenase family
Vgang_RS13525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vgang_RS13530	COG0668	transmembrane transport
Vgang_RS13535	COG0569	domain protein
Vgang_RS13540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vgang_RS13545	COG3304	Inner membrane component domain
Vgang_RS13550	COG1765	OsmC-like protein
Vgang_RS13590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Vgang_RS13600	COG0156	8-amino-7-oxononanoate synthase activity
Vgang_RS13605	COG1063	alcohol dehydrogenase
Vgang_RS13610	COG0582	viral genome integration into host DNA
Vgang_RS13655	COG5532	Uncharacterized conserved protein (DUF2303)
Vgang_RS13705	COG1802	Transcriptional regulator
Vgang_RS13705	COG4626	Terminase
Vgang_RS13725	COG1403	HNH endonuclease
Vgang_RS13750	COG3772	lysozyme
Vgang_RS13785	COG0740	serine-type endopeptidase activity
Vgang_RS13885	COG3646	Phage regulatory protein
Vgang_RS13905	COG0420	3'-5' exonuclease activity
Vgang_RS13910	COG0419	ATPase involved in DNA repair
Vgang_RS13915	COG0179	Fumarylacetoacetate (FAA) hydrolase
Vgang_RS13930	COG4221	oxidoreductase activity
Vgang_RS13935	COG0443	Heat shock 70 kDa protein
Vgang_RS13955	COG1823	symporter activity
Vgang_RS13960	COG1280	lysine exporter protein (LysE YggA)
Vgang_RS13985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vgang_RS13990	COG1254	Belongs to the acylphosphatase family
Vgang_RS13995	COG2920	part of a sulfur-relay system
Vgang_RS14000	COG0670	Belongs to the BI1 family
Vgang_RS14010	COG1126	abc transporter atp-binding protein
Vgang_RS14015	COG0765	amino acid transport
Vgang_RS14020	COG4597	amino acid ABC transporter
Vgang_RS14025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vgang_RS14035	COG2988	succinylglutamate desuccinylase activity
Vgang_RS14040	COG4139	cobalamin transport
Vgang_RS14060	COG0583	DNA-binding transcription factor activity
Vgang_RS14065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vgang_RS14070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vgang_RS14095	COG3040	lipid binding
Vgang_RS14120	COG4115	mRNA cleavage
Vgang_RS14125	COG0513	Belongs to the DEAD box helicase family
Vgang_RS14140	COG3122	Protein conserved in bacteria
Vgang_RS14150	COG0625	glutathione transferase activity
Vgang_RS14175	COG1116	anion transmembrane transporter activity
Vgang_RS14180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vgang_RS14185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vgang_RS14190	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Vgang_RS14205	COG1301	dicarboxylic acid transport
Vgang_RS14210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vgang_RS14225	COG1763	Mo-molybdopterin cofactor biosynthetic process
Vgang_RS14230	COG0746	molybdenum cofactor guanylyltransferase activity
Vgang_RS14240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vgang_RS14245	COG1793	dna ligase
Vgang_RS14250	COG0534	Mate efflux family protein
Vgang_RS14260	COG3001	Fructosamine kinase
Vgang_RS14265	COG0791	NLP P60 protein
Vgang_RS14270	COG1940	carbohydrate kinase activity
Vgang_RS14290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Vgang_RS14300	COG1177	transmembrane transport
Vgang_RS14305	COG1176	ABC-type spermidine putrescine transport system, permease component I
Vgang_RS14310	COG3842	ATPase activity
Vgang_RS14330	COG0037	tRNA processing
Vgang_RS14335	COG0589	response to stress
Vgang_RS14340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vgang_RS14355	COG2217	Heavy metal translocating P-type atpase
Vgang_RS14365	COG2010	Cytochrome c
Vgang_RS14380	COG3278	Belongs to the heme-copper respiratory oxidase family
Vgang_RS14400	COG3085	chromosome segregation
Vgang_RS14405	COG0583	DNA-binding transcription factor activity
Vgang_RS14435	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Vgang_RS14440	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Vgang_RS14455	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Vgang_RS14470	COG0656	L-ascorbic acid biosynthetic process
Vgang_RS14475	COG0583	DNA-binding transcription factor activity
Vgang_RS14485	COG1794	racemase activity, acting on amino acids and derivatives
Vgang_RS14495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vgang_RS14505	COG0521	Mo-molybdopterin cofactor biosynthetic process
Vgang_RS14520	COG2207	Transcriptional regulator
Vgang_RS14520	COG3708	Transcriptional regulator
Vgang_RS14535	COG1215	transferase activity, transferring glycosyl groups
Vgang_RS14540	COG3769	mannosylglycerate metabolic process
Vgang_RS14550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Vgang_RS14555	COG4149	molybdate abc transporter
Vgang_RS14560	COG0725	ABC transporter, periplasmic molybdate-binding protein
Vgang_RS14565	COG3585	molybdate ion transport
Vgang_RS14565	COG2005	Transcriptional regulator
Vgang_RS14570	COG1492	cobalamin metabolic process
Vgang_RS14575	COG0346	lactoylglutathione lyase activity
Vgang_RS14580	COG4067	protein conserved in archaea
Vgang_RS14580	COG0189	ligase activity
Vgang_RS14590	COG0602	queuosine metabolic process
Vgang_RS14595	COG1328	CTP reductase activity
Vgang_RS14605	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Vgang_RS14610	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Vgang_RS14615	COG4181	ATPase activity
Vgang_RS14625	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Vgang_RS14635	COG1451	nucleotide metabolic process
Vgang_RS14650	COG1869	D-ribose catabolic process
Vgang_RS14655	COG1129	ABC transporter
Vgang_RS14660	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vgang_RS14665	COG1879	ABC-type sugar transport system periplasmic component
Vgang_RS14670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vgang_RS14675	COG1609	Transcriptional regulator
Vgang_RS14680	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
Vgang_RS14685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vgang_RS14705	COG1278	Cold shock
Vgang_RS14710	COG0095	Lipoate-protein ligase
Vgang_RS14725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vgang_RS14755	COG0523	cobalamin synthesis protein
Vgang_RS14765	COG0004	ammonium transporteR
Vgang_RS14780	COG1640	4-alpha-glucanotransferase
Vgang_RS14795	COG0405	Gamma-glutamyltransferase
Vgang_RS14800	COG1902	pentaerythritol trinitrate reductase activity
Vgang_RS14805	COG0656	L-ascorbic acid biosynthetic process
Vgang_RS14820	COG0471	metal ion transport
Vgang_RS14820	COG0490	domain, Protein
Vgang_RS14825	COG3833	ABC-type maltose transport systems, permease component
Vgang_RS14830	COG1175	transmembrane transport
Vgang_RS14835	COG2182	Extracellular solute-binding protein
Vgang_RS14840	COG3842	ATPase activity
Vgang_RS14860	COG3290	protein histidine kinase activity
Vgang_RS14865	COG4565	transcriptional regulatory protein
Vgang_RS14880	COG0366	Alpha amylase catalytic
Vgang_RS14910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vgang_RS14915	COG0583	DNA-binding transcription factor activity
Vgang_RS14930	COG0513	Belongs to the DEAD box helicase family
Vgang_RS14935	COG3314	Sporulation integral membrane protein YlbJ
Vgang_RS14945	COG2205	protein histidine kinase activity
Vgang_RS14945	COG2770	Histidine kinase
Vgang_RS14965	COG1346	cytolysis
Vgang_RS14970	COG1380	Effector of murein hydrolase LrgA
Vgang_RS14975	COG0583	DNA-binding transcription factor activity
Vgang_RS14980	COG0798	PFAM Bile acid sodium symporter
Vgang_RS14985	COG0640	Transcriptional regulator
Vgang_RS14990	COG5492	domain, Protein
Vgang_RS14990	COG4932	domain protein
Vgang_RS14995	COG2885	chlorophyll binding
Vgang_RS14995	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Vgang_RS15000	COG1881	PFAM PEBP family protein
Vgang_RS15005	COG2207	Transcriptional regulator
Vgang_RS15010	COG3829	transcription factor binding
Vgang_RS15015	COG2204	response regulator
Vgang_RS15020	COG0516	GMP reductase activity
Vgang_RS15040	COG1803	Methylglyoxal synthase
Vgang_RS15045	COG1879	ABC-type sugar transport system periplasmic component
Vgang_RS15050	COG1129	ABC transporter
Vgang_RS15055	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vgang_RS15060	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vgang_RS15080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vgang_RS15100	COG0210	DNA helicase
Vgang_RS15105	COG1289	transmembrane transporter activity
Vgang_RS15110	COG1984	allophanate hydrolase subunit 2
Vgang_RS15115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Vgang_RS15125	COG2132	Multicopper oxidase
Vgang_RS15155	COG0110	maltose O-acetyltransferase activity
Vgang_RS15165	COG0516	GMP reductase activity
Vgang_RS15165	COG0517	IMP dehydrogenase activity
Vgang_RS15180	COG0402	S-adenosylhomocysteine deaminase activity
Vgang_RS15200	COG0814	amino acid
Vgang_RS15205	COG1309	transcriptional regulator
Vgang_RS15210	COG2723	6-phospho-beta-galactosidase activity
Vgang_RS15215	COG1940	carbohydrate kinase activity
Vgang_RS15220	COG1940	carbohydrate kinase activity
Vgang_RS15245	COG1609	Transcriptional regulator
Vgang_RS15250	COG3842	ATPase activity
Vgang_RS15255	COG2942	2-epimerase
Vgang_RS15260	COG5578	integral membrane protein
Vgang_RS15265	COG0395	ABC-type sugar transport system, permease component
Vgang_RS15270	COG1175	transmembrane transport
Vgang_RS15275	COG2084	Dehydrogenase
Vgang_RS15280	COG3622	Belongs to the hyi family
Vgang_RS15285	COG3960	tartronate-semialdehyde synthase activity
Vgang_RS15290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Vgang_RS15300	COG2186	Transcriptional regulator
Vgang_RS15320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Vgang_RS15325	COG1054	Belongs to the UPF0176 family
Vgang_RS15340	COG3724	N-succinylarginine dihydrolase activity
Vgang_RS15345	COG1012	belongs to the aldehyde dehydrogenase family
Vgang_RS15370	COG4993	Dehydrogenase
Vgang_RS15375	COG1879	ABC-type sugar transport system periplasmic component
Vgang_RS15380	COG1129	ABC transporter
Vgang_RS15385	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vgang_RS15390	COG1971	Probably functions as a manganese efflux pump
Vgang_RS15395	COG1538	Outer membrane efflux protein
Vgang_RS15400	COG1136	(ABC) transporter
Vgang_RS15400	COG0577	efflux transmembrane transporter activity
Vgang_RS15405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vgang_RS15425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Vgang_RS15430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Vgang_RS15440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vgang_RS15455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Vgang_RS15460	COG0247	lactate metabolic process
Vgang_RS15460	COG0277	FAD linked oxidase domain protein
Vgang_RS15485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Vgang_RS15490	COG3530	Putative quorum-sensing-regulated virulence factor
Vgang_RS15500	COG0714	Associated with various cellular activities
Vgang_RS15520	COG2304	oxidoreductase activity
Vgang_RS15530	COG1609	Transcriptional regulator
Vgang_RS15540	COG1874	Beta-galactosidase
Vgang_RS15550	COG3833	ABC-type maltose transport systems, permease component
Vgang_RS15555	COG1175	transmembrane transport
Vgang_RS15560	COG2182	Extracellular solute-binding protein
Vgang_RS15575	COG0671	phosphoesterase, PA-phosphatase related
Vgang_RS15580	COG2814	Major facilitator Superfamily
Vgang_RS15590	COG2017	converts alpha-aldose to the beta-anomer
Vgang_RS15595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Vgang_RS15600	COG1085	galactose-1-phosphate uridylyltransferase
Vgang_RS15605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Vgang_RS15610	COG0737	Belongs to the 5'-nucleotidase family
Vgang_RS15625	COG5413	integral membrane protein
Vgang_RS15645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Vgang_RS15655	COG4681	YaeQ
Vgang_RS15680	COG2354	Protein conserved in bacteria
Vgang_RS15685	COG1757	Na H antiporter
Vgang_RS15700	COG3302	dmso reductase anchor subunit
Vgang_RS15705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vgang_RS15705	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vgang_RS15710	COG2885	chlorophyll binding
Vgang_RS15720	COG1067	ATP-dependent peptidase activity
Vgang_RS15735	COG0702	epimerase
Vgang_RS15750	COG0739	heme binding
Vgang_RS15755	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Vgang_RS15760	COG0830	nickel cation binding
Vgang_RS15770	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Vgang_RS15775	COG0804	urea catabolic process
Vgang_RS15780	COG0832	Belongs to the urease beta subunit family
Vgang_RS15785	COG0831	urea catabolic process
Vgang_RS15790	COG0829	nickel cation binding
Vgang_RS15805	COG0668	transmembrane transport
Vgang_RS15820	COG4214	carbohydrate transport
Vgang_RS15840	COG0583	DNA-binding transcription factor activity
Vgang_RS15845	COG3257	ureidoglycine aminohydrolase activity
Vgang_RS15850	COG5002	protein histidine kinase activity
Vgang_RS15860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Vgang_RS15865	COG2194	sulfuric ester hydrolase activity
Vgang_RS15880	COG2267	carboxylic ester hydrolase activity
Vgang_RS15900	COG0573	inorganic phosphate transmembrane transporter activity
Vgang_RS15910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Vgang_RS15920	COG0573	inorganic phosphate transmembrane transporter activity
Vgang_RS15925	COG0581	inorganic phosphate transmembrane transporter activity
Vgang_RS15930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Vgang_RS15935	COG2199	diguanylate cyclase activity
Vgang_RS15940	COG0307	riboflavin synthase, alpha
Vgang_RS15945	COG2197	response regulator
Vgang_RS15950	COG3850	Histidine kinase
Vgang_RS15965	COG0243	molybdopterin cofactor binding
Vgang_RS15975	COG3005	denitrification pathway
Vgang_RS15985	COG4221	oxidoreductase activity
Vgang_RS15995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vgang_RS16000	COG2146	nitrite reductase [NAD(P)H] activity
Vgang_RS16005	COG2116	formate transmembrane transporter activity
Vgang_RS16010	COG1648	precorrin-2 dehydrogenase activity
Vgang_RS16010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vgang_RS16015	COG2827	Endonuclease containing a URI domain
Vgang_RS16020	COG3132	Protein of unknown function, DUF480
Vgang_RS16035	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Vgang_RS16040	COG0513	Belongs to the DEAD box helicase family
Vgang_RS16045	COG1609	Transcriptional regulator
Vgang_RS16050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vgang_RS16050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vgang_RS16055	COG1105	Belongs to the carbohydrate kinase PfkB family
Vgang_RS16060	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Vgang_RS16060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vgang_RS16060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vgang_RS16080	COG0318	PFAM AMP-dependent synthetase and ligase
Vgang_RS16090	COG0109	protoheme IX farnesyltransferase activity
Vgang_RS16120	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Vgang_RS16125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Vgang_RS16130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Vgang_RS16135	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Vgang_RS16160	COG2814	Major facilitator Superfamily
Vgang_RS16165	COG0583	DNA-binding transcription factor activity
Vgang_RS16185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vgang_RS16190	COG4172	Belongs to the ABC transporter superfamily
Vgang_RS16230	COG0625	glutathione transferase activity
Vgang_RS16245	COG0697	spore germination
Vgang_RS16250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vgang_RS16265	COG0154	amidase activity
Vgang_RS16270	COG1357	PFAM Pentapeptide repeats (8 copies)
Vgang_RS16280	COG1349	DNA-binding transcription factor activity
Vgang_RS16285	COG1597	lipid kinase activity
Vgang_RS16285	COG1803	Methylglyoxal synthase
Vgang_RS16295	COG3842	ATPase activity
Vgang_RS16300	COG1176	ABC-type spermidine putrescine transport system, permease component I
Vgang_RS16305	COG1177	transmembrane transport
Vgang_RS16310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vgang_RS16335	COG1278	Cold shock
Vgang_RS16340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vgang_RS16360	COG0259	pyridoxamine-phosphate oxidase activity
Vgang_RS16365	COG1444	tRNA N-acetyltransferase activity
Vgang_RS16505	COG3328	transposase activity
Vgang_RS16540	COG3344	reverse transcriptase
Vgang_RS16650	COG1357	PFAM Pentapeptide repeats (8 copies)
Vgang_RS16860	COG2003	Belongs to the UPF0758 family
Vgang_RS17050	COG1192	Involved in chromosome partitioning