locus-tag	class	description
EPB58_RS00035	COG1595	DNA-templated transcription, initiation
EPB58_RS00065	COG4166	transmembrane transport
EPB58_RS00135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB58_RS00190	COG1132	(ABC) transporter
EPB58_RS00205	COG0516	GMP reductase activity
EPB58_RS00205	COG0517	IMP dehydrogenase activity
EPB58_RS00215	COG0641	radical SAM
EPB58_RS00220	COG4580	involved in the transport of maltose and maltodextrins
EPB58_RS00225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EPB58_RS00235	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EPB58_RS00240	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS00245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS00250	COG0800	Aldolase
EPB58_RS00265	COG3119	arylsulfatase activity
EPB58_RS00270	COG2149	membrane
EPB58_RS00295	COG2957	Belongs to the agmatine deiminase family
EPB58_RS00300	COG0531	amino acid
EPB58_RS00305	COG0549	Belongs to the carbamate kinase family
EPB58_RS00320	COG0800	Aldolase
EPB58_RS00325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS00330	COG1904	glucuronate isomerase
EPB58_RS00335	COG0246	Mannitol dehydrogenase
EPB58_RS00345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB58_RS00355	COG2186	Transcriptional regulator
EPB58_RS00360	COG1312	Catalyzes the dehydration of D-mannonate
EPB58_RS00365	COG3655	Transcriptional regulator
EPB58_RS00380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EPB58_RS00385	COG1595	DNA-templated transcription, initiation
EPB58_RS00395	COG0513	Belongs to the DEAD box helicase family
EPB58_RS00400	COG3713	MltA-interacting MipA family protein
EPB58_RS00410	COG2153	protein acetylation
EPB58_RS00415	COG2258	MOSC domain
EPB58_RS00430	COG1522	sequence-specific DNA binding
EPB58_RS00450	COG0346	lactoylglutathione lyase activity
EPB58_RS00495	COG0366	Alpha amylase catalytic
EPB58_RS00500	COG0583	DNA-binding transcription factor activity
EPB58_RS00530	COG3734	2-keto-3-deoxy-galactonokinase
EPB58_RS00535	COG0800	Aldolase
EPB58_RS00540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB58_RS00545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB58_RS00545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB58_RS00550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB58_RS00550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB58_RS00555	COG4948	Mandelate Racemase Muconate Lactonizing
EPB58_RS00560	COG0129	dihydroxy-acid dehydratase activity
EPB58_RS00570	COG3634	alkyl hydroperoxide reductase activity
EPB58_RS00585	COG1846	Transcriptional regulator
EPB58_RS00590	COG1764	response to oxidative stress
EPB58_RS00610	COG0612	Peptidase, M16
EPB58_RS00635	COG0739	heme binding
EPB58_RS00660	COG4604	ABC transporter, ATP-binding protein
EPB58_RS00665	COG4605	iron ion homeostasis
EPB58_RS00670	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB58_RS00675	COG4607	ABC-type enterochelin transport system periplasmic component
EPB58_RS00680	COG0583	DNA-binding transcription factor activity
EPB58_RS00685	COG4771	TonB-dependent receptor
EPB58_RS00705	COG2814	Major facilitator Superfamily
EPB58_RS00720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPB58_RS00740	COG2203	Gaf domain
EPB58_RS00740	COG2199	diguanylate cyclase activity
EPB58_RS00750	COG4580	involved in the transport of maltose and maltodextrins
EPB58_RS00765	COG0366	Alpha amylase catalytic
EPB58_RS00770	COG2356	endonuclease I
EPB58_RS00775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB58_RS00820	COG0456	acetyltransferase
EPB58_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS00855	COG0671	phosphoesterase, PA-phosphatase related
EPB58_RS00870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EPB58_RS00875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPB58_RS00880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPB58_RS00885	COG1116	anion transmembrane transporter activity
EPB58_RS00890	COG0351	phosphomethylpyrimidine kinase
EPB58_RS00895	COG0312	modulator of DNA gyrase
EPB58_RS00900	COG0312	modulator of DNA gyrase
EPB58_RS00965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB58_RS00975	COG0584	glycerophosphoryl diester phosphodiesterase
EPB58_RS00985	COG0745	RESPONSE REGULATOR receiver
EPB58_RS01005	COG0811	peptide transport
EPB58_RS01010	COG0811	peptide transport
EPB58_RS01015	COG0848	biopolymer transport protein
EPB58_RS01060	COG0803	Belongs to the bacterial solute-binding protein 9 family
EPB58_RS01065	COG1121	(ABC) transporter
EPB58_RS01070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB58_RS01085	COG1770	oligopeptidase
EPB58_RS01090	COG2814	Major facilitator Superfamily
EPB58_RS01095	COG0010	Belongs to the arginase family
EPB58_RS01100	COG1166	arginine decarboxylase activity
EPB58_RS01110	COG4067	protein conserved in archaea
EPB58_RS01110	COG0189	ligase activity
EPB58_RS01115	COG0189	ligase activity
EPB58_RS01135	COG0583	DNA-binding transcription factor activity
EPB58_RS01175	COG1114	Component of the transport system for branched-chain amino acids
EPB58_RS01195	COG0579	oxidoreductase
EPB58_RS01205	COG3179	chitinase
EPB58_RS01225	COG3033	Beta-eliminating lyase
EPB58_RS01240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB58_RS01245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB58_RS01265	COG3706	GGDEF domain
EPB58_RS01280	COG3706	GGDEF domain
EPB58_RS01285	COG0415	Belongs to the DNA photolyase family
EPB58_RS01290	COG3046	protein related to deoxyribodipyrimidine photolyase
EPB58_RS01305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB58_RS01305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB58_RS01310	COG1765	OsmC-like protein
EPB58_RS01360	COG1011	Hydrolase
EPB58_RS01395	COG3240	lipase activity
EPB58_RS01425	COG1609	Transcriptional regulator
EPB58_RS01435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB58_RS01445	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB58_RS01475	COG2990	Protein conserved in bacteria
EPB58_RS01485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB58_RS01490	COG2866	Carboxypeptidase
EPB58_RS01500	COG0583	DNA-binding transcription factor activity
EPB58_RS01525	COG3104	oligopeptide transport
EPB58_RS01530	COG1760	l-serine dehydratase
EPB58_RS01555	COG0741	lytic transglycosylase activity
EPB58_RS01555	COG1388	LysM domain
EPB58_RS01575	COG1815	bacterial-type flagellum-dependent cell motility
EPB58_RS01580	COG1558	bacterial-type flagellum-dependent cell motility
EPB58_RS01590	COG1749	Flagellar hook protein flgE
EPB58_RS01595	COG4787	bacterial-type flagellum-dependent cell motility
EPB58_RS01600	COG4786	Flagellar basal body rod
EPB58_RS01605	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB58_RS01610	COG1706	bacterial-type flagellum-dependent cell motility
EPB58_RS01620	COG4786	Flagellar basal body rod
EPB58_RS01620	COG1256	bacterial-type flagellum assembly
EPB58_RS01660	COG1253	flavin adenine dinucleotide binding
EPB58_RS01680	COG2226	methyltransferase
EPB58_RS01700	COG0672	)-iron permease
EPB58_RS01715	COG0577	efflux transmembrane transporter activity
EPB58_RS01715	COG1136	(ABC) transporter
EPB58_RS01725	COG1136	(ABC) transporter
EPB58_RS01740	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB58_RS01790	COG1360	Flagellar Motor Protein
EPB58_RS01795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB58_RS01800	COG1191	sigma factor activity
EPB58_RS01805	COG1580	Controls the rotational direction of flagella during chemotaxis
EPB58_RS01820	COG1516	flagellar protein fliS
EPB58_RS01825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB58_RS01835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB58_RS01850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EPB58_RS01860	COG1987	bacterial-type flagellum assembly
EPB58_RS02005	COG0346	lactoylglutathione lyase activity
EPB58_RS02030	COG0745	RESPONSE REGULATOR receiver
EPB58_RS02055	COG0156	8-amino-7-oxononanoate synthase activity
EPB58_RS02060	COG1063	alcohol dehydrogenase
EPB58_RS02115	COG3338	carbonate dehydratase activity
EPB58_RS02145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB58_RS02155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB58_RS02190	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EPB58_RS02205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB58_RS02235	COG0786	glutamate:sodium symporter activity
EPB58_RS02240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EPB58_RS02245	COG1538	Outer membrane efflux protein
EPB58_RS02255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB58_RS02260	COG0583	DNA-binding transcription factor activity
EPB58_RS02275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB58_RS02280	COG2197	response regulator
EPB58_RS02290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB58_RS02290	COG0574	Belongs to the PEP-utilizing enzyme family
EPB58_RS02300	COG0252	asparaginase activity
EPB58_RS02310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB58_RS02315	COG0583	DNA-binding transcription factor activity
EPB58_RS02335	COG3122	Protein conserved in bacteria
EPB58_RS02350	COG1902	pentaerythritol trinitrate reductase activity
EPB58_RS02360	COG2814	Major facilitator Superfamily
EPB58_RS02365	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS02390	COG0583	DNA-binding transcription factor activity
EPB58_RS02400	COG0513	Belongs to the DEAD box helicase family
EPB58_RS02420	COG0095	Lipoate-protein ligase
EPB58_RS02440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB58_RS02445	COG2207	Transcriptional regulator
EPB58_RS02445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB58_RS02450	COG0583	DNA-binding transcription factor activity
EPB58_RS02460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB58_RS02495	COG1566	PFAM secretion protein HlyD family protein
EPB58_RS02500	COG0583	DNA-binding transcription factor activity
EPB58_RS02515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS02515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS02515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS02520	COG2207	Transcriptional regulator
EPB58_RS02530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS02535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS02540	COG0583	DNA-binding transcription factor activity
EPB58_RS02550	COG2084	Dehydrogenase
EPB58_RS02555	COG0753	catalase activity
EPB58_RS02565	COG2130	NADP-dependent
EPB58_RS02570	COG1309	transcriptional regulator
EPB58_RS02605	COG0438	transferase activity, transferring glycosyl groups
EPB58_RS02615	COG3206	protein involved in exopolysaccharide biosynthesis
EPB58_RS02615	COG0489	protein tyrosine kinase activity
EPB58_RS02635	COG3842	ATPase activity
EPB58_RS02645	COG1175	transmembrane transport
EPB58_RS02650	COG3833	ABC-type maltose transport systems, permease component
EPB58_RS02695	COG0741	lytic transglycosylase activity
EPB58_RS02720	COG2354	Protein conserved in bacteria
EPB58_RS02735	COG0401	homolog of Blt101
EPB58_RS02740	COG3217	Mosc domain protein beta barrel domain protein
EPB58_RS02740	COG0633	Ferredoxin
EPB58_RS02740	COG3217	Mosc domain protein beta barrel domain protein
EPB58_RS02740	COG0633	Ferredoxin
EPB58_RS02750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EPB58_RS02790	COG0583	DNA-binding transcription factor activity
EPB58_RS02810	COG2814	Major facilitator Superfamily
EPB58_RS02820	COG1335	isochorismatase
EPB58_RS02825	COG4977	sequence-specific DNA binding
EPB58_RS02835	COG2194	sulfuric ester hydrolase activity
EPB58_RS02840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB58_RS02850	COG2205	protein histidine kinase activity
EPB58_RS02855	COG0745	RESPONSE REGULATOR receiver
EPB58_RS02860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB58_RS02865	COG4948	Mandelate Racemase Muconate Lactonizing
EPB58_RS02870	COG1053	succinate dehydrogenase
EPB58_RS02870	COG3976	FMN-binding domain protein
EPB58_RS02885	COG4221	oxidoreductase activity
EPB58_RS02900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB58_RS02920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB58_RS02945	COG1418	mRNA catabolic process
EPB58_RS02960	COG0402	S-adenosylhomocysteine deaminase activity
EPB58_RS02965	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EPB58_RS02970	COG2239	Acts as a magnesium transporter
EPB58_RS02975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPB58_RS02980	COG1566	PFAM secretion protein HlyD family protein
EPB58_RS03005	COG0745	RESPONSE REGULATOR receiver
EPB58_RS03010	COG2205	protein histidine kinase activity
EPB58_RS03020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB58_RS03025	COG0531	amino acid
EPB58_RS03030	COG1522	sequence-specific DNA binding
EPB58_RS03040	COG0583	DNA-binding transcription factor activity
EPB58_RS03060	COG0784	Response regulator, receiver
EPB58_RS03060	COG5002	protein histidine kinase activity
EPB58_RS03060	COG2205	protein histidine kinase activity
EPB58_RS03065	COG0673	inositol 2-dehydrogenase activity
EPB58_RS03070	COG0534	Mate efflux family protein
EPB58_RS03075	COG2926	Belongs to the UPF0265 family
EPB58_RS03140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB58_RS03145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB58_RS03155	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS03165	COG0183	Belongs to the thiolase family
EPB58_RS03185	COG3005	denitrification pathway
EPB58_RS03205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB58_RS03210	COG3850	Histidine kinase
EPB58_RS03215	COG2197	response regulator
EPB58_RS03230	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB58_RS03250	COG0840	transmembrane signaling receptor activity
EPB58_RS03260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB58_RS03290	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB58_RS03300	COG2885	chlorophyll binding
EPB58_RS03320	COG1278	Cold shock
EPB58_RS03325	COG3036	rescue of stalled ribosome
EPB58_RS03335	COG2199	diguanylate cyclase activity
EPB58_RS03355	COG1136	(ABC) transporter
EPB58_RS03355	COG0577	efflux transmembrane transporter activity
EPB58_RS03385	COG1538	Outer membrane efflux protein
EPB58_RS03390	COG2205	protein histidine kinase activity
EPB58_RS03390	COG0784	Response regulator, receiver
EPB58_RS03415	COG0840	transmembrane signaling receptor activity
EPB58_RS03420	COG0783	Belongs to the Dps family
EPB58_RS03430	COG1619	proteins homologs of microcin C7 resistance protein MccF
EPB58_RS03435	COG2133	pyrroloquinoline quinone binding
EPB58_RS03440	COG1454	alcohol dehydrogenase
EPB58_RS03450	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EPB58_RS03470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB58_RS03475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB58_RS03480	COG3186	Phenylalanine-4-hydroxylase
EPB58_RS03515	COG3530	Putative quorum-sensing-regulated virulence factor
EPB58_RS03550	COG1289	transmembrane transporter activity
EPB58_RS03555	COG0210	DNA helicase
EPB58_RS03565	COG1879	ABC-type sugar transport system periplasmic component
EPB58_RS03570	COG2205	protein histidine kinase activity
EPB58_RS03570	COG0784	Response regulator, receiver
EPB58_RS03570	COG2198	Histidine kinase
EPB58_RS03600	COG3119	arylsulfatase activity
EPB58_RS03605	COG3119	arylsulfatase activity
EPB58_RS03615	COG0583	DNA-binding transcription factor activity
EPB58_RS03620	COG3119	arylsulfatase activity
EPB58_RS03625	COG0641	radical SAM
EPB58_RS03630	COG0714	Associated with various cellular activities
EPB58_RS03690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPB58_RS03700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPB58_RS03710	COG0583	DNA-binding transcription factor activity
EPB58_RS03715	COG1597	lipid kinase activity
EPB58_RS03720	COG3111	PFAM Bacterial OB fold (BOF) protein
EPB58_RS03740	COG0641	radical SAM
EPB58_RS03765	COG0501	Belongs to the peptidase M48B family
EPB58_RS03770	COG1704	LemA family
EPB58_RS03775	COG3069	C4-dicarboxylate transmembrane transporter activity
EPB58_RS03805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EPB58_RS03820	COG0477	Major facilitator Superfamily
EPB58_RS03820	COG2814	Major facilitator Superfamily
EPB58_RS03825	COG1940	carbohydrate kinase activity
EPB58_RS03830	COG2017	converts alpha-aldose to the beta-anomer
EPB58_RS03835	COG0019	diaminopimelate decarboxylase activity
EPB58_RS03840	COG4264	IucA IucC family
EPB58_RS03865	COG4772	TonB-dependent receptor
EPB58_RS03870	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EPB58_RS03875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB58_RS03880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB58_RS03885	COG1120	ATPase activity
EPB58_RS03890	COG4771	TonB-dependent receptor
EPB58_RS03905	COG0784	Response regulator, receiver
EPB58_RS03905	COG2205	protein histidine kinase activity
EPB58_RS03910	COG5001	Diguanylate cyclase
EPB58_RS03910	COG3300	MHYT domain
EPB58_RS03915	COG2197	response regulator
EPB58_RS03920	COG3706	GGDEF domain
EPB58_RS03930	COG2197	response regulator
EPB58_RS03940	COG0778	Nitroreductase
EPB58_RS03945	COG0784	Response regulator, receiver
EPB58_RS03945	COG0835	chemotaxis
EPB58_RS03950	COG2165	general secretion pathway protein
EPB58_RS03960	COG2962	Rard protein
EPB58_RS03985	COG3278	Belongs to the heme-copper respiratory oxidase family
EPB58_RS04025	COG1024	Enoyl-CoA hydratase
EPB58_RS04030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPB58_RS04035	COG1960	acyl-CoA dehydrogenase activity
EPB58_RS04045	COG0183	Belongs to the thiolase family
EPB58_RS04060	COG1024	Enoyl-CoA hydratase
EPB58_RS04065	COG1024	Enoyl-CoA hydratase
EPB58_RS04075	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS04080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB58_RS04085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPB58_RS04090	COG1845	cytochrome c oxidase, subunit III
EPB58_RS04095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EPB58_RS04115	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB58_RS04115	COG1902	pentaerythritol trinitrate reductase activity
EPB58_RS04120	COG0671	phosphoesterase, PA-phosphatase related
EPB58_RS04160	COG1132	(ABC) transporter
EPB58_RS04175	COG1733	regulation of RNA biosynthetic process
EPB58_RS04185	COG2176	DNA-directed DNA polymerase activity
EPB58_RS04270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB58_RS04280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EPB58_RS04290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB58_RS04295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB58_RS04325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS04325	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPB58_RS04325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS04330	COG1105	Belongs to the carbohydrate kinase PfkB family
EPB58_RS04335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS04335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS04340	COG1609	Transcriptional regulator
EPB58_RS04355	COG2203	Gaf domain
EPB58_RS04355	COG2200	EAL domain
EPB58_RS04355	COG2199	diguanylate cyclase activity
EPB58_RS04360	COG0765	amino acid transport
EPB58_RS04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB58_RS04370	COG0765	amino acid transport
EPB58_RS04375	COG1126	abc transporter atp-binding protein
EPB58_RS04385	COG1979	alcohol dehydrogenase
EPB58_RS04390	COG2207	Transcriptional regulator
EPB58_RS04400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB58_RS04410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS04425	COG0784	Response regulator, receiver
EPB58_RS04425	COG3437	response regulator, receiver
EPB58_RS04430	COG0546	phosphoglycolate phosphatase activity
EPB58_RS04450	COG0513	Belongs to the DEAD box helicase family
EPB58_RS04455	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EPB58_RS04470	COG3038	cytochrome b561
EPB58_RS04480	COG2116	formate transmembrane transporter activity
EPB58_RS04485	COG0583	DNA-binding transcription factor activity
EPB58_RS04495	COG3593	DNA synthesis involved in DNA repair
EPB58_RS04500	COG0737	Belongs to the 5'-nucleotidase family
EPB58_RS04520	COG1410	methionine synthase
EPB58_RS04520	COG0646	methionine synthase
EPB58_RS04535	COG2267	carboxylic ester hydrolase activity
EPB58_RS04540	COG2067	long-chain fatty acid transport protein
EPB58_RS04555	COG2050	protein possibly involved in aromatic compounds catabolism
EPB58_RS04565	COG4533	DNA binding
EPB58_RS04590	COG0484	heat shock protein binding
EPB58_RS04600	COG5001	Diguanylate cyclase
EPB58_RS04600	COG3300	MHYT domain
EPB58_RS04605	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB58_RS04620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EPB58_RS04630	COG1984	allophanate hydrolase subunit 2
EPB58_RS04635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EPB58_RS04645	COG3447	MASE1 domain protein
EPB58_RS04645	COG5001	Diguanylate cyclase
EPB58_RS04645	COG5002	protein histidine kinase activity
EPB58_RS04650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPB58_RS04665	COG0583	DNA-binding transcription factor activity
EPB58_RS04675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB58_RS04675	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB58_RS04675	COG1042	CoA-binding domain protein
EPB58_RS04695	COG0023	Translation Initiation Factor
EPB58_RS04790	COG3140	Belongs to the UPF0181 family
EPB58_RS04815	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EPB58_RS04820	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPB58_RS04835	COG3706	GGDEF domain
EPB58_RS04850	COG5001	Diguanylate cyclase
EPB58_RS04850	COG4251	negative regulation of phosphorylation
EPB58_RS04850	COG2203	Gaf domain
EPB58_RS04850	COG3706	GGDEF domain
EPB58_RS04860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EPB58_RS04865	COG4149	molybdate abc transporter
EPB58_RS04870	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPB58_RS04880	COG3111	PFAM Bacterial OB fold (BOF) protein
EPB58_RS04890	COG0189	ligase activity
EPB58_RS04890	COG4067	protein conserved in archaea
EPB58_RS04905	COG0534	Mate efflux family protein
EPB58_RS04910	COG0602	queuosine metabolic process
EPB58_RS04915	COG1328	CTP reductase activity
EPB58_RS04975	COG2197	response regulator
EPB58_RS04980	COG3851	Histidine kinase
EPB58_RS04985	COG2271	Major facilitator Superfamily
EPB58_RS04990	COG1482	cell wall glycoprotein biosynthetic process
EPB58_RS05000	COG0628	permease
EPB58_RS05010	COG1566	PFAM secretion protein HlyD family protein
EPB58_RS05035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB58_RS05040	COG3118	belongs to the thioredoxin family
EPB58_RS05050	COG3292	Two component regulator propeller
EPB58_RS05050	COG2205	protein histidine kinase activity
EPB58_RS05050	COG0745	RESPONSE REGULATOR receiver
EPB58_RS05085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB58_RS05105	COG2116	formate transmembrane transporter activity
EPB58_RS05115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB58_RS05120	COG5001	Diguanylate cyclase
EPB58_RS05190	COG0277	FAD linked oxidase domain protein
EPB58_RS05195	COG0583	DNA-binding transcription factor activity
EPB58_RS05205	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EPB58_RS05220	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EPB58_RS05230	COG1288	antiporter activity
EPB58_RS05240	COG2814	Major facilitator Superfamily
EPB58_RS05250	COG3040	lipid binding
EPB58_RS05280	COG3469	chitinase activity
EPB58_RS05290	COG0419	ATPase involved in DNA repair
EPB58_RS05295	COG0420	3'-5' exonuclease activity
EPB58_RS05390	COG0631	protein serine/threonine phosphatase activity
EPB58_RS05425	COG0515	serine threonine protein kinase
EPB58_RS05425	COG2815	serine threonine protein kinase
EPB58_RS05445	COG0346	lactoylglutathione lyase activity
EPB58_RS05450	COG1902	pentaerythritol trinitrate reductase activity
EPB58_RS05460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPB58_RS05460	COG2755	lipolytic protein G-D-S-L family
EPB58_RS05470	COG5642	Protein of unknown function (DUF2384)
EPB58_RS05485	COG1234	tRNA 3'-trailer cleavage
EPB58_RS05490	COG2067	long-chain fatty acid transport protein
EPB58_RS05570	COG1024	Enoyl-CoA hydratase
EPB58_RS05575	COG0628	permease
EPB58_RS05600	COG3038	cytochrome b561
EPB58_RS05610	COG0739	heme binding
EPB58_RS05660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB58_RS05660	COG2146	nitrite reductase [NAD(P)H] activity
EPB58_RS05665	COG1116	anion transmembrane transporter activity
EPB58_RS05670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPB58_RS05675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPB58_RS05675	COG1116	anion transmembrane transporter activity
EPB58_RS05695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPB58_RS05700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPB58_RS05700	COG1648	precorrin-2 dehydrogenase activity
EPB58_RS05705	COG0243	molybdopterin cofactor binding
EPB58_RS05710	COG0456	acetyltransferase
EPB58_RS05720	COG0814	amino acid
EPB58_RS05730	COG3706	GGDEF domain
EPB58_RS05750	COG1785	Belongs to the alkaline phosphatase family
EPB58_RS05765	COG0745	RESPONSE REGULATOR receiver
EPB58_RS05795	COG2847	Copper chaperone PCu(A)C
EPB58_RS05800	COG0443	Heat shock 70 kDa protein
EPB58_RS05855	COG3976	FMN-binding domain protein
EPB58_RS05855	COG1053	succinate dehydrogenase
EPB58_RS05855	COG0431	NADPH-dependent FMN reductase
EPB58_RS05860	COG5002	protein histidine kinase activity
EPB58_RS05895	COG4160	amino acid transport
EPB58_RS05900	COG4215	(ABC) transporter
EPB58_RS05905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB58_RS05910	COG1126	abc transporter atp-binding protein
EPB58_RS05945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB58_RS05955	COG1012	belongs to the aldehyde dehydrogenase family
EPB58_RS05965	COG0583	DNA-binding transcription factor activity
EPB58_RS05970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB58_RS05975	COG0513	Belongs to the DEAD box helicase family
EPB58_RS05980	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EPB58_RS05995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPB58_RS06010	COG2205	protein histidine kinase activity
EPB58_RS06015	COG0745	RESPONSE REGULATOR receiver
EPB58_RS06020	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EPB58_RS06025	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EPB58_RS06035	COG1119	ATPase activity
EPB58_RS06040	COG2200	EAL domain
EPB58_RS06040	COG2771	luxR family
EPB58_RS06060	COG0513	Belongs to the DEAD box helicase family
EPB58_RS06065	COG3447	MASE1 domain protein
EPB58_RS06065	COG5001	Diguanylate cyclase
EPB58_RS06065	COG5002	protein histidine kinase activity
EPB58_RS06070	COG0523	cobalamin synthesis protein
EPB58_RS06095	COG4206	TonB-dependent receptor
EPB58_RS06105	COG0789	Transcriptional regulator
EPB58_RS06110	COG4604	ABC transporter, ATP-binding protein
EPB58_RS06115	COG4605	iron ion homeostasis
EPB58_RS06120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB58_RS06125	COG4607	ABC-type enterochelin transport system periplasmic component
EPB58_RS06140	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EPB58_RS06155	COG1609	Transcriptional regulator
EPB58_RS06160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS06165	COG1879	ABC-type sugar transport system periplasmic component
EPB58_RS06170	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB58_RS06175	COG1129	ABC transporter
EPB58_RS06185	COG5001	Diguanylate cyclase
EPB58_RS06190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB58_RS06195	COG1794	racemase activity, acting on amino acids and derivatives
EPB58_RS06220	COG0586	Pfam SNARE associated Golgi protein
EPB58_RS06260	COG2205	protein histidine kinase activity
EPB58_RS06260	COG0784	Response regulator, receiver
EPB58_RS06270	COG0784	Response regulator, receiver
EPB58_RS06270	COG2205	protein histidine kinase activity
EPB58_RS06290	COG0330	HflC and HflK could
EPB58_RS06305	COG0517	IMP dehydrogenase activity
EPB58_RS06305	COG4175	Glycine betaine
EPB58_RS06310	COG4176	ABC-type proline glycine betaine transport system permease component
EPB58_RS06340	COG3706	GGDEF domain
EPB58_RS06350	COG0402	S-adenosylhomocysteine deaminase activity
EPB58_RS06365	COG0204	Acyl-transferase
EPB58_RS06395	COG2885	chlorophyll binding
EPB58_RS06435	COG0455	bacterial-type flagellum organization
EPB58_RS06445	COG4964	Belongs to the GSP D family
EPB58_RS06465	COG0583	DNA-binding transcription factor activity
EPB58_RS06470	COG1073	alpha beta
EPB58_RS06495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPB58_RS06520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPB58_RS06540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPB58_RS06540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPB58_RS06555	COG4989	oxidoreductase activity
EPB58_RS06580	COG1914	H( )-stimulated, divalent metal cation uptake system
EPB58_RS06595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB58_RS06610	COG2897	thiosulfate sulfurtransferase activity
EPB58_RS06635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB58_RS06640	COG0840	transmembrane signaling receptor activity
EPB58_RS06645	COG2814	Major facilitator Superfamily
EPB58_RS06650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB58_RS06665	COG1612	heme a metabolic process
EPB58_RS06685	COG1845	cytochrome c oxidase, subunit III
EPB58_RS06690	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EPB58_RS06700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB58_RS06705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB58_RS06715	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS06735	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPB58_RS06750	COG0697	spore germination
EPB58_RS06770	COG2814	Major facilitator Superfamily
EPB58_RS06775	COG0583	DNA-binding transcription factor activity
EPB58_RS06780	COG5001	Diguanylate cyclase
EPB58_RS06785	COG0739	heme binding
EPB58_RS06810	COG3314	Sporulation integral membrane protein YlbJ
EPB58_RS06825	COG0814	amino acid
EPB58_RS06845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPB58_RS06850	COG1072	(Pantothenic acid kinase))
EPB58_RS06860	COG1063	alcohol dehydrogenase
EPB58_RS06865	COG2213	PTS system mannitol-specific
EPB58_RS06870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS06875	COG2188	Transcriptional regulator
EPB58_RS06880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS06880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS06880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS06885	COG0383	alpha-mannosidase activity
EPB58_RS06890	COG1482	cell wall glycoprotein biosynthetic process
EPB58_RS06895	COG0747	negative chemotaxis
EPB58_RS06905	COG1733	regulation of RNA biosynthetic process
EPB58_RS06920	COG0798	PFAM Bile acid sodium symporter
EPB58_RS06935	COG1881	PFAM PEBP family protein
EPB58_RS06945	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB58_RS07015	COG0366	Alpha amylase catalytic
EPB58_RS07025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPB58_RS07030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB58_RS07035	COG0784	Response regulator, receiver
EPB58_RS07035	COG0835	chemotaxis
EPB58_RS07045	COG0748	coenzyme F420 binding
EPB58_RS07050	COG3721	Heme iron utilization protein
EPB58_RS07060	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPB58_RS07065	COG0811	peptide transport
EPB58_RS07070	COG0848	biopolymer transport protein
EPB58_RS07080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB58_RS07085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EPB58_RS07090	COG0840	transmembrane signaling receptor activity
EPB58_RS07105	COG0842	Transport permease protein
EPB58_RS07110	COG0251	oxidation-reduction process
EPB58_RS07125	COG0800	Aldolase
EPB58_RS07130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS07135	COG4145	pantothenate transmembrane transporter activity
EPB58_RS07145	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EPB58_RS07170	COG3383	formate dehydrogenase (NAD+) activity
EPB58_RS07190	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB58_RS07215	COG3321	synthase
EPB58_RS07215	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS07215	COG0604	alcohol dehydrogenase
EPB58_RS07220	COG0456	acetyltransferase
EPB58_RS07240	COG0612	Peptidase, M16
EPB58_RS07245	COG4178	(ABC) transporter
EPB58_RS07250	COG4771	TonB-dependent receptor
EPB58_RS07260	COG0811	peptide transport
EPB58_RS07265	COG0811	peptide transport
EPB58_RS07270	COG0848	biopolymer transport protein
EPB58_RS07295	COG1858	cytochrome C peroxidase
EPB58_RS07305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB58_RS07315	COG1505	serine-type exopeptidase activity
EPB58_RS07320	COG0488	(ABC) transporter
EPB58_RS07325	COG1720	tRNA m6t6A37 methyltransferase activity
EPB58_RS07345	COG2814	Major facilitator Superfamily
EPB58_RS07360	COG0583	DNA-binding transcription factor activity
EPB58_RS07365	COG0589	response to stress
EPB58_RS07390	COG1175	transmembrane transport
EPB58_RS07395	COG0395	ABC-type sugar transport system, permease component
EPB58_RS07400	COG3842	ATPase activity
EPB58_RS07430	COG0523	cobalamin synthesis protein
EPB58_RS07440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPB58_RS07450	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB58_RS07455	COG1741	Belongs to the pirin family
EPB58_RS07460	COG1278	Cold shock
EPB58_RS07475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB58_RS07505	COG2226	methyltransferase
EPB58_RS07515	COG3706	GGDEF domain
EPB58_RS07520	COG1686	Belongs to the peptidase S11 family
EPB58_RS07525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB58_RS07530	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB58_RS07535	COG0583	DNA-binding transcription factor activity
EPB58_RS07540	COG0625	glutathione transferase activity
EPB58_RS07550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPB58_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS07605	COG3746	phosphate-selective porin O and P
EPB58_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS07630	COG1301	dicarboxylic acid transport
EPB58_RS07635	COG1252	NADH dehydrogenase
EPB58_RS07645	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
EPB58_RS07650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPB58_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS07690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB58_RS07700	COG0573	inorganic phosphate transmembrane transporter activity
EPB58_RS07710	COG4191	Histidine kinase
EPB58_RS07720	COG0110	maltose O-acetyltransferase activity
EPB58_RS07755	COG0840	transmembrane signaling receptor activity
EPB58_RS07760	COG0714	Associated with various cellular activities
EPB58_RS07780	COG2304	oxidoreductase activity
EPB58_RS07795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB58_RS07800	COG0581	inorganic phosphate transmembrane transporter activity
EPB58_RS07805	COG0573	inorganic phosphate transmembrane transporter activity
EPB58_RS07815	COG0840	transmembrane signaling receptor activity
EPB58_RS07825	COG0513	Belongs to the DEAD box helicase family
EPB58_RS07835	COG1388	LysM domain
EPB58_RS07835	COG1376	ErfK ybiS ycfS ynhG family protein
EPB58_RS07840	COG0415	Belongs to the DNA photolyase family
EPB58_RS07845	COG0789	Transcriptional regulator
EPB58_RS07850	COG3272	Protein of unknown function (DUF1722)
EPB58_RS07860	COG0813	purine-nucleoside phosphorylase activity
EPB58_RS07890	COG1566	PFAM secretion protein HlyD family protein
EPB58_RS07900	COG1122	ATPase activity
EPB58_RS07920	COG0348	domain, Protein
EPB58_RS07925	COG0437	4 iron, 4 sulfur cluster binding
EPB58_RS07930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB58_RS07960	COG1067	ATP-dependent peptidase activity
EPB58_RS07970	COG4172	Belongs to the ABC transporter superfamily
EPB58_RS07975	COG1505	serine-type exopeptidase activity
EPB58_RS07980	COG0583	DNA-binding transcription factor activity
EPB58_RS07985	COG1620	l-lactate permease
EPB58_RS07990	COG1304	FMN binding
EPB58_RS08000	COG0668	transmembrane transport
EPB58_RS08015	COG4948	Mandelate Racemase Muconate Lactonizing
EPB58_RS08020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB58_RS08040	COG1342	Belongs to the UPF0251 family
EPB58_RS08050	COG4176	ABC-type proline glycine betaine transport system permease component
EPB58_RS08055	COG4175	Glycine betaine
EPB58_RS08055	COG3448	diguanylate cyclase activity
EPB58_RS08065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB58_RS08070	COG0589	response to stress
EPB58_RS08075	COG0583	DNA-binding transcription factor activity
EPB58_RS08125	COG1335	isochorismatase
EPB58_RS08140	COG0753	catalase activity
EPB58_RS08165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EPB58_RS08170	COG1263	PTS System
EPB58_RS08170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS08175	COG1609	Transcriptional regulator
EPB58_RS08180	COG1349	DNA-binding transcription factor activity
EPB58_RS08185	COG0346	lactoylglutathione lyase activity
EPB58_RS08190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB58_RS08190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB58_RS08200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS08200	COG1263	PTS System
EPB58_RS08205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB58_RS08210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EPB58_RS08215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB58_RS08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB58_RS08240	COG0561	phosphatase activity
EPB58_RS08255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS08260	COG3537	Alpha-1,2-mannosidase
EPB58_RS08265	COG3537	Alpha-1,2-mannosidase
EPB58_RS08275	COG3537	Alpha-1,2-mannosidase
EPB58_RS08295	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS08300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB58_RS08315	COG3226	Transcriptional regulator
EPB58_RS08320	COG0583	DNA-binding transcription factor activity
EPB58_RS08335	COG0488	(ABC) transporter
EPB58_RS08340	COG0435	Glutathione S-transferase
EPB58_RS08345	COG0431	NADPH-dependent FMN reductase
EPB58_RS08350	COG0583	DNA-binding transcription factor activity
EPB58_RS08355	COG4628	conserved protein (DUF2132)
EPB58_RS08360	COG0488	(ABC) transporter
EPB58_RS08375	COG0346	lactoylglutathione lyase activity
EPB58_RS08380	COG0384	phenazine biosynthesis protein PhzF
EPB58_RS08395	COG3220	belongs to the UPF0276 family
EPB58_RS08410	COG1271	oxidase subunit
EPB58_RS08415	COG1294	oxidase, subunit
EPB58_RS08460	COG2207	Transcriptional regulator
EPB58_RS08470	COG1882	Formate acetyltransferase
EPB58_RS08475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB58_RS08480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPB58_RS08495	COG2205	protein histidine kinase activity
EPB58_RS08500	COG0745	RESPONSE REGULATOR receiver
EPB58_RS08510	COG0454	-acetyltransferase
EPB58_RS08520	COG2814	Major facilitator Superfamily
EPB58_RS08535	COG0583	DNA-binding transcription factor activity
EPB58_RS08540	COG2988	succinylglutamate desuccinylase activity
EPB58_RS08580	COG0628	permease
EPB58_RS08585	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB58_RS08600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB58_RS08610	COG4628	conserved protein (DUF2132)
EPB58_RS08615	COG0583	DNA-binding transcription factor activity
EPB58_RS08640	COG1686	Belongs to the peptidase S11 family
EPB58_RS08655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EPB58_RS08675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB58_RS08680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB58_RS08695	COG0415	Belongs to the DNA photolyase family
EPB58_RS08700	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPB58_RS08710	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB58_RS08715	COG2095	MarC family integral membrane protein
EPB58_RS08725	COG1596	polysaccharide export
EPB58_RS08750	COG0583	DNA-binding transcription factor activity
EPB58_RS08780	COG1301	dicarboxylic acid transport
EPB58_RS08790	COG3339	Conserved Protein
EPB58_RS08795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB58_RS08800	COG0700	Nucleoside recognition
EPB58_RS08805	COG3366	ferrous iron transmembrane transporter activity
EPB58_RS08820	COG0366	Alpha amylase catalytic
EPB58_RS08825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB58_RS08830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPB58_RS08835	COG1640	4-alpha-glucanotransferase
EPB58_RS08840	COG0058	SHG alpha-glucan phosphorylase activity
EPB58_RS08860	COG1999	signal sequence binding
EPB58_RS08870	COG1263	PTS System
EPB58_RS08870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS08875	COG1162	GTPase activity
EPB58_RS08880	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EPB58_RS08885	COG0673	inositol 2-dehydrogenase activity
EPB58_RS08910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS08915	COG0673	inositol 2-dehydrogenase activity
EPB58_RS08920	COG3962	Belongs to the TPP enzyme family
EPB58_RS08930	COG0477	Major facilitator Superfamily
EPB58_RS08930	COG2814	Major facilitator Superfamily
EPB58_RS08935	COG0583	DNA-binding transcription factor activity
EPB58_RS08950	COG0183	Belongs to the thiolase family
EPB58_RS08980	COG0531	amino acid
EPB58_RS08985	COG1982	Orn Lys Arg decarboxylase major
EPB58_RS09005	COG1929	Belongs to the glycerate kinase type-1 family
EPB58_RS09010	COG3835	regulator
EPB58_RS09020	COG1228	amidohydrolase
EPB58_RS09045	COG0546	phosphoglycolate phosphatase activity
EPB58_RS09080	COG1132	(ABC) transporter
EPB58_RS09085	COG1132	(ABC) transporter
EPB58_RS09090	COG4771	TonB-dependent receptor
EPB58_RS09130	COG3408	Glycogen debranching enzyme
EPB58_RS09130	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EPB58_RS09150	COG2814	Major facilitator Superfamily
EPB58_RS09165	COG2358	TRAP transporter, solute receptor (TAXI family
EPB58_RS09170	COG3047	cAMP biosynthetic process
EPB58_RS09175	COG1357	PFAM Pentapeptide repeats (8 copies)
EPB58_RS09200	COG2076	Multidrug Resistance protein
EPB58_RS09235	COG0583	DNA-binding transcription factor activity
EPB58_RS09250	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EPB58_RS09265	COG3152	Membrane
EPB58_RS09275	COG2199	diguanylate cyclase activity
EPB58_RS09285	COG0561	phosphatase activity
EPB58_RS09295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EPB58_RS09300	COG0564	pseudouridine synthase activity
EPB58_RS09305	COG0534	Mate efflux family protein
EPB58_RS09310	COG1609	Transcriptional regulator
EPB58_RS09315	COG3842	ATPase activity
EPB58_RS09320	COG2723	6-phospho-beta-galactosidase activity
EPB58_RS09325	COG0395	ABC-type sugar transport system, permease component
EPB58_RS09340	COG1609	Transcriptional regulator
EPB58_RS09345	COG4580	involved in the transport of maltose and maltodextrins
EPB58_RS09350	COG5001	Diguanylate cyclase
EPB58_RS09415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EPB58_RS09425	COG0826	peptidase U32
EPB58_RS09445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS09450	COG3716	PTS system mannose fructose sorbose family IID component
EPB58_RS09460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS09465	COG2222	sugar isomerase
EPB58_RS09475	COG1349	DNA-binding transcription factor activity
EPB58_RS09480	COG1349	DNA-binding transcription factor activity
EPB58_RS09490	COG1136	(ABC) transporter
EPB58_RS09495	COG0577	efflux transmembrane transporter activity
EPB58_RS09525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPB58_RS09540	COG2259	Doxx family
EPB58_RS09580	COG3623	hexulose-6-phosphate isomerase
EPB58_RS09585	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EPB58_RS09590	COG0561	phosphatase activity
EPB58_RS09635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB58_RS09640	COG0251	oxidation-reduction process
EPB58_RS09665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EPB58_RS09670	COG2207	Transcriptional regulator
EPB58_RS09680	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EPB58_RS09685	COG0830	nickel cation binding
EPB58_RS09690	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EPB58_RS09695	COG0804	urea catabolic process
EPB58_RS09700	COG0832	Belongs to the urease beta subunit family
EPB58_RS09705	COG0831	urea catabolic process
EPB58_RS09710	COG0829	nickel cation binding
EPB58_RS09725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB58_RS09745	COG0786	glutamate:sodium symporter activity
EPB58_RS09750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB58_RS09755	COG1131	(ABC) transporter
EPB58_RS09770	COG0786	glutamate:sodium symporter activity
EPB58_RS09795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB58_RS09800	COG3279	Response regulator of the LytR AlgR family
EPB58_RS09805	COG3275	phosphorelay sensor kinase activity
EPB58_RS09835	COG0583	DNA-binding transcription factor activity
EPB58_RS09840	COG1566	PFAM secretion protein HlyD family protein
EPB58_RS09850	COG0772	Belongs to the SEDS family
EPB58_RS09875	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
EPB58_RS09875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB58_RS09885	COG0444	Belongs to the ABC transporter superfamily
EPB58_RS09890	COG4608	Belongs to the ABC transporter superfamily
EPB58_RS09915	COG1444	tRNA N-acetyltransferase activity
EPB58_RS09920	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPB58_RS09925	COG0848	biopolymer transport protein
EPB58_RS09935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB58_RS09960	COG1288	antiporter activity
EPB58_RS09970	COG2186	Transcriptional regulator
EPB58_RS09980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB58_RS09985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB58_RS10000	COG4771	TonB-dependent receptor
EPB58_RS10005	COG0583	DNA-binding transcription factor activity
EPB58_RS10025	COG0747	negative chemotaxis
EPB58_RS10030	COG4608	Belongs to the ABC transporter superfamily
EPB58_RS10035	COG0444	Belongs to the ABC transporter superfamily
EPB58_RS10040	COG0534	Mate efflux family protein
EPB58_RS10065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB58_RS10080	COG2824	Alkylphosphonate utilization operon protein PhnA
EPB58_RS10085	COG1621	beta-fructofuranosidase activity
EPB58_RS10090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS10095	COG1263	PTS System
EPB58_RS10095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS10110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPB58_RS10115	COG0789	Transcriptional regulator
EPB58_RS10130	COG0457	Tetratricopeptide repeat
EPB58_RS10200	COG4790	Type iii secretion
EPB58_RS10205	COG4794	Type iii secretion
EPB58_RS10210	COG4791	protein targeting
EPB58_RS10215	COG4792	protein secretion
EPB58_RS10260	COG4669	(LipO)protein
EPB58_RS10340	COG0784	Response regulator, receiver
EPB58_RS10340	COG5002	protein histidine kinase activity
EPB58_RS10350	COG0754	glutathionylspermidine amidase activity
EPB58_RS10360	COG3766	membrane
EPB58_RS10380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB58_RS10385	COG0371	Dehydrogenase
EPB58_RS10390	COG2207	Transcriptional regulator
EPB58_RS10395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS10400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPB58_RS10405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB58_RS10410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB58_RS10415	COG1882	Formate acetyltransferase
EPB58_RS10420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS10425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB58_RS10430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS10430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS10430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB58_RS10435	COG0673	inositol 2-dehydrogenase activity
EPB58_RS10450	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EPB58_RS10455	COG2885	chlorophyll binding
EPB58_RS10460	COG0823	Involved in the tonB-independent uptake of proteins
EPB58_RS10475	COG0811	peptide transport
EPB58_RS10480	COG0824	Thioesterase
EPB58_RS10490	COG4890	Cyd operon protein YbgT
EPB58_RS10495	COG1294	oxidase, subunit
EPB58_RS10500	COG1271	oxidase subunit
EPB58_RS10510	COG0632	four-way junction helicase activity
EPB58_RS10515	COG0840	transmembrane signaling receptor activity
EPB58_RS10530	COG1801	Protein of unknown function DUF72
EPB58_RS10550	COG0189	ligase activity
EPB58_RS10550	COG4067	protein conserved in archaea
EPB58_RS10570	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EPB58_RS10575	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EPB58_RS10585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB58_RS10590	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB58_RS10595	COG0745	RESPONSE REGULATOR receiver
EPB58_RS10610	COG3070	regulator of competence-specific genes
EPB58_RS10630	COG0297	glycogen (starch) synthase activity
EPB58_RS10635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB58_RS10640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB58_RS10670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPB58_RS10675	COG0542	response to heat
EPB58_RS10685	COG1278	Cold shock
EPB58_RS10695	COG1187	pseudouridine synthase activity
EPB58_RS10700	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB58_RS10710	COG1199	ATP-dependent helicase activity
EPB58_RS10715	COG0730	response to heat
EPB58_RS10730	COG0840	transmembrane signaling receptor activity
EPB58_RS10735	COG0708	Exodeoxyribonuclease III
EPB58_RS10775	COG1882	Formate acetyltransferase
EPB58_RS10785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB58_RS10800	COG2766	serine protein kinase
EPB58_RS10805	COG2718	Belongs to the UPF0229 family
EPB58_RS10810	COG2719	SpoVR family
EPB58_RS10830	COG1132	(ABC) transporter
EPB58_RS10845	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB58_RS10850	COG1136	(ABC) transporter
EPB58_RS10855	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB58_RS10865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPB58_RS10880	COG1252	NADH dehydrogenase
EPB58_RS10910	COG0537	adenosine 5'-monophosphoramidase activity
EPB58_RS10930	COG2217	Heavy metal translocating P-type atpase
EPB58_RS10940	COG0617	tRNA 3'-terminal CCA addition
EPB58_RS10940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EPB58_RS10940	COG0517	IMP dehydrogenase activity
EPB58_RS10945	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EPB58_RS10950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EPB58_RS10955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB58_RS10960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EPB58_RS10985	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EPB58_RS10990	COG1946	Acyl-CoA thioesterase
EPB58_RS11000	COG1522	sequence-specific DNA binding
EPB58_RS11025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB58_RS11075	COG0477	Major facilitator Superfamily
EPB58_RS11080	COG2855	membrane
EPB58_RS11090	COG0583	DNA-binding transcription factor activity
EPB58_RS11095	COG2190	(PTS) system
EPB58_RS11095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS11095	COG1263	PTS System
EPB58_RS11110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EPB58_RS11115	COG0596	Alpha beta hydrolase
EPB58_RS11125	COG1169	isochorismate synthase
EPB58_RS11130	COG0436	Aminotransferase
EPB58_RS11135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EPB58_RS11160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB58_RS11165	COG0776	regulation of translation
EPB58_RS11170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPB58_RS11205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB58_RS11210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB58_RS11215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB58_RS11230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB58_RS11235	COG0569	domain protein
EPB58_RS11240	COG0513	Belongs to the DEAD box helicase family
EPB58_RS11245	COG1253	flavin adenine dinucleotide binding
EPB58_RS11250	COG4771	TonB-dependent receptor
EPB58_RS11265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPB58_RS11265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPB58_RS11270	COG3433	isochorismatase activity
EPB58_RS11270	COG1535	isochorismatase
EPB58_RS11275	COG1021	2,3-dihydroxybenzoate-AMP ligase
EPB58_RS11280	COG1169	isochorismate synthase
EPB58_RS11290	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS11305	COG2226	methyltransferase
EPB58_RS11335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB58_RS11340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB58_RS11360	COG1216	Glycosyl transferase, family 2
EPB58_RS11365	COG2986	histidine ammonia-lyase
EPB58_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS11435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB58_RS11445	COG2951	lytic endotransglycosylase activity
EPB58_RS11460	COG2894	cell division
EPB58_RS11465	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EPB58_RS11470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EPB58_RS11475	COG0318	PFAM AMP-dependent synthetase and ligase
EPB58_RS11480	COG2267	carboxylic ester hydrolase activity
EPB58_RS11485	COG3065	identical protein binding
EPB58_RS11495	COG1214	PFAM Peptidase M22, glycoprotease
EPB58_RS11500	COG1199	ATP-dependent helicase activity
EPB58_RS11505	COG0788	formyltetrahydrofolate deformylase activity
EPB58_RS11510	COG3102	Protein conserved in bacteria
EPB58_RS11545	COG1918	ferrous iron import across plasma membrane
EPB58_RS11550	COG4977	sequence-specific DNA binding
EPB58_RS11555	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EPB58_RS11560	COG1121	(ABC) transporter
EPB58_RS11565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB58_RS11580	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB58_RS11585	COG0567	Dehydrogenase, E1 component
EPB58_RS11595	COG1053	succinate dehydrogenase
EPB58_RS11600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPB58_RS11615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPB58_RS11625	COG0033	Phosphoglucomutase
EPB58_RS11630	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EPB58_RS11635	COG0596	Alpha beta hydrolase
EPB58_RS11645	COG0716	FMN binding
EPB58_RS11655	COG0735	belongs to the Fur family
EPB58_RS11660	COG2165	general secretion pathway protein
EPB58_RS11670	COG1263	PTS System
EPB58_RS11670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS11670	COG2190	(PTS) system
EPB58_RS11680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPB58_RS11685	COG1940	carbohydrate kinase activity
EPB58_RS11685	COG1846	Transcriptional regulator
EPB58_RS11690	COG4651	solute:proton antiporter activity
EPB58_RS11690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB58_RS11695	COG0367	asparagine synthase
EPB58_RS11705	COG3104	oligopeptide transport
EPB58_RS11710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPB58_RS11725	COG3710	Transcriptional regulator
EPB58_RS11745	COG0622	Phosphoesterase
EPB58_RS11775	COG1090	epimerase
EPB58_RS11780	COG0300	oxidoreductase activity
EPB58_RS11790	COG3118	belongs to the thioredoxin family
EPB58_RS11795	COG0330	HflC and HflK could
EPB58_RS11825	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EPB58_RS11830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPB58_RS11840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS11845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB58_RS11850	COG2190	(PTS) system
EPB58_RS11855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB58_RS11860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB58_RS11865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB58_RS11880	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPB58_RS11880	COG3951	Flagellar rod assembly protein muramidase FlgJ
EPB58_RS11885	COG1706	bacterial-type flagellum-dependent cell motility
EPB58_RS11890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB58_RS11900	COG4787	bacterial-type flagellum-dependent cell motility
EPB58_RS11920	COG1558	bacterial-type flagellum-dependent cell motility
EPB58_RS11925	COG1815	bacterial-type flagellum-dependent cell motility
EPB58_RS11930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPB58_RS11935	COG0835	chemotaxis
EPB58_RS11935	COG0784	Response regulator, receiver
EPB58_RS11990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB58_RS12005	COG2217	Heavy metal translocating P-type atpase
EPB58_RS12005	COG2608	mercury ion transmembrane transporter activity
EPB58_RS12045	COG2840	Smr protein MutS2
EPB58_RS12050	COG1187	pseudouridine synthase activity
EPB58_RS12055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPB58_RS12060	COG0737	Belongs to the 5'-nucleotidase family
EPB58_RS12065	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPB58_RS12070	COG2912	Transglutaminase-like superfamily
EPB58_RS12075	COG3094	Invasion gene expression up-regulator, SirB
EPB58_RS12080	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB58_RS12105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPB58_RS12230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB58_RS12245	COG1702	phosphate starvation-inducible protein PhoH
EPB58_RS12255	COG4535	Mg2 and Co2 transporter CorC
EPB58_RS12260	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPB58_RS12265	COG2888	peptidyl-tyrosine sulfation
EPB58_RS12275	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EPB58_RS12280	COG1466	dna polymerase III delta subunit
EPB58_RS12285	COG0799	negative regulation of ribosome biogenesis
EPB58_RS12295	COG0768	penicillin binding
EPB58_RS12300	COG0772	Belongs to the SEDS family
EPB58_RS12305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPB58_RS12310	COG1686	Belongs to the peptidase S11 family
EPB58_RS12330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB58_RS12335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EPB58_RS12350	COG0366	Alpha amylase catalytic
EPB58_RS12355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS12355	COG1263	PTS System
EPB58_RS12365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB58_RS12370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPB58_RS12375	COG2011	ABC-type metal ion transport system permease component
EPB58_RS12380	COG1464	Belongs to the NlpA lipoprotein family
EPB58_RS12390	COG0737	Belongs to the 5'-nucleotidase family
EPB58_RS12395	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EPB58_RS12420	COG1611	Belongs to the LOG family
EPB58_RS12440	COG2363	Small membrane protein
EPB58_RS12450	COG0583	DNA-binding transcription factor activity
EPB58_RS12465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB58_RS12475	COG0142	geranyltranstransferase activity
EPB58_RS12485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EPB58_RS12490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPB58_RS12515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB58_RS12515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB58_RS12520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPB58_RS12525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPB58_RS12540	COG1073	alpha beta
EPB58_RS12545	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EPB58_RS12550	COG2252	PERMEase
EPB58_RS12555	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB58_RS12585	COG0047	phosphoribosylformylglycinamidine synthase activity
EPB58_RS12585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPB58_RS12605	COG0590	tRNA wobble adenosine to inosine editing
EPB58_RS12610	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB58_RS12630	COG4969	Belongs to the N-Me-Phe pilin family
EPB58_RS12650	COG1301	dicarboxylic acid transport
EPB58_RS12670	COG0497	DNA recombination
EPB58_RS12675	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB58_RS12680	COG2914	Belongs to the UPF0125 (RnfH) family
EPB58_RS12685	COG2867	negative regulation of translational initiation
EPB58_RS12705	COG0745	RESPONSE REGULATOR receiver
EPB58_RS12740	COG0583	DNA-binding transcription factor activity
EPB58_RS12745	COG1289	transmembrane transporter activity
EPB58_RS12765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPB58_RS12785	COG0719	Fe-S assembly protein
EPB58_RS12790	COG0396	ATPase activity
EPB58_RS12795	COG0719	Fe-S assembly protein
EPB58_RS12800	COG0316	Belongs to the HesB IscA family
EPB58_RS12805	COG2873	o-acetylhomoserine
EPB58_RS12810	COG0668	transmembrane transport
EPB58_RS12815	COG0583	DNA-binding transcription factor activity
EPB58_RS12825	COG1115	amino acid carrier protein
EPB58_RS12830	COG1584	GPR1 FUN34 yaaH family protein
EPB58_RS12840	COG1757	Na H antiporter
EPB58_RS12850	COG0516	GMP reductase activity
EPB58_RS12850	COG0517	IMP dehydrogenase activity
EPB58_RS12865	COG2199	diguanylate cyclase activity
EPB58_RS12865	COG2203	Gaf domain
EPB58_RS12880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB58_RS12885	COG2976	Protein conserved in bacteria
EPB58_RS12920	COG2975	iron-sulfur cluster assembly
EPB58_RS12925	COG0633	Ferredoxin
EPB58_RS12940	COG0316	Belongs to the HesB IscA family
EPB58_RS12945	COG0822	iron-sulfur transferase activity
EPB58_RS12960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EPB58_RS12965	COG0483	inositol monophosphate 1-phosphatase activity
EPB58_RS12975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB58_RS12980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB58_RS12985	COG1862	Preprotein translocase
EPB58_RS13010	COG0517	IMP dehydrogenase activity
EPB58_RS13020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPB58_RS13025	COG0583	DNA-binding transcription factor activity
EPB58_RS13030	COG0450	alkyl hydroperoxide reductase
EPB58_RS13060	COG0704	Plays a role in the regulation of phosphate uptake
EPB58_RS13065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB58_RS13070	COG0581	inorganic phosphate transmembrane transporter activity
EPB58_RS13075	COG0573	inorganic phosphate transmembrane transporter activity
EPB58_RS13080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPB58_RS13085	COG0248	Ppx GppA phosphatase
EPB58_RS13095	COG5002	protein histidine kinase activity
EPB58_RS13100	COG0745	RESPONSE REGULATOR receiver
EPB58_RS13110	COG0826	peptidase U32
EPB58_RS13115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB58_RS13125	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EPB58_RS13175	COG0542	response to heat
EPB58_RS13180	COG1496	oxidoreductase activity
EPB58_RS13185	COG0564	pseudouridine synthase activity
EPB58_RS13190	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB58_RS13195	COG0741	lytic transglycosylase activity
EPB58_RS13200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB58_RS13205	COG0077	Prephenate dehydratase
EPB58_RS13205	COG1605	Chorismate mutase
EPB58_RS13210	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EPB58_RS13225	COG0488	(ABC) transporter
EPB58_RS13235	COG0739	heme binding
EPB58_RS13240	COG0287	Prephenate dehydrogenase
EPB58_RS13240	COG1605	Chorismate mutase
EPB58_RS13245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB58_RS13255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPB58_RS13275	COG1966	Carbon starvation protein
EPB58_RS13280	COG3275	phosphorelay sensor kinase activity
EPB58_RS13285	COG3279	Response regulator of the LytR AlgR family
EPB58_RS13290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPB58_RS13295	COG1047	Peptidyl-prolyl cis-trans
EPB58_RS13310	COG0196	riboflavin kinase activity
EPB58_RS13315	COG0728	peptidoglycan biosynthetic process
EPB58_RS13320	COG0268	Binds directly to 16S ribosomal RNA
EPB58_RS13325	COG0640	Transcriptional regulator
EPB58_RS13330	COG0583	DNA-binding transcription factor activity
EPB58_RS13335	COG1283	sodium-dependent phosphate transmembrane transporter activity
EPB58_RS13350	COG0730	response to heat
EPB58_RS13355	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EPB58_RS13375	COG0667	Aldo Keto reductase
EPB58_RS13400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPB58_RS13405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB58_RS13415	COG0716	FMN binding
EPB58_RS13430	COG0513	Belongs to the DEAD box helicase family
EPB58_RS13440	COG3022	response to hydroperoxide
EPB58_RS13445	COG1115	amino acid carrier protein
EPB58_RS13480	COG0431	NADPH-dependent FMN reductase
EPB58_RS13485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPB58_RS13490	COG0083	homoserine kinase activity
EPB58_RS13505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB58_RS13520	COG0745	RESPONSE REGULATOR receiver
EPB58_RS13530	COG0784	Response regulator, receiver
EPB58_RS13530	COG2198	Histidine kinase
EPB58_RS13530	COG5002	protein histidine kinase activity
EPB58_RS13535	COG4251	negative regulation of phosphorylation
EPB58_RS13535	COG3706	GGDEF domain
EPB58_RS13535	COG5001	Diguanylate cyclase
EPB58_RS13535	COG2203	Gaf domain
EPB58_RS13540	COG1242	4 iron, 4 sulfur cluster binding
EPB58_RS13545	COG0067	glutamate synthase
EPB58_RS13545	COG0069	glutamate synthase activity
EPB58_RS13545	COG0070	glutamate synthase
EPB58_RS13555	COG0067	glutamate synthase
EPB58_RS13555	COG0069	glutamate synthase activity
EPB58_RS13555	COG0070	glutamate synthase
EPB58_RS13560	COG0493	'glutamate synthase
EPB58_RS13585	COG2860	membrane
EPB58_RS13590	COG0583	DNA-binding transcription factor activity
EPB58_RS13595	COG0730	response to heat
EPB58_RS13610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPB58_RS13615	COG0505	Belongs to the CarA family
EPB58_RS13625	COG0494	nUDIX hydrolase
EPB58_RS13640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPB58_RS13645	COG0849	cell division
EPB58_RS13650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPB58_RS13665	COG0772	Belongs to the SEDS family
EPB58_RS13680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPB58_RS13685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPB58_RS13690	COG0768	penicillin binding
EPB58_RS13695	COG3116	cell division
EPB58_RS13715	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPB58_RS13730	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB58_RS13735	COG2823	Periplasmic or secreted lipoprotein
EPB58_RS13740	COG2969	positive regulation of protein catabolic process
EPB58_RS13745	COG0625	glutathione transferase activity
EPB58_RS13750	COG2857	Cytochrome c1
EPB58_RS13755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EPB58_RS13760	COG0723	plastoquinol--plastocyanin reductase activity
EPB58_RS13780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPB58_RS13790	COG3105	Protein conserved in bacteria
EPB58_RS13800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPB58_RS13805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EPB58_RS13815	COG3150	esterase
EPB58_RS13825	COG3151	Protein conserved in bacteria
EPB58_RS13830	COG0494	nUDIX hydrolase
EPB58_RS13835	COG1538	Outer membrane efflux protein
EPB58_RS13845	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EPB58_RS13855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB58_RS13860	COG3025	triphosphatase activity
EPB58_RS13865	COG1392	Phosphate transport regulator
EPB58_RS13870	COG0306	phosphate transporter
EPB58_RS13875	COG4991	sh3 domain protein
EPB58_RS13885	COG3409	Peptidoglycan-binding domain 1 protein
EPB58_RS13885	COG3267	Type II secretory pathway component ExeA
EPB58_RS13900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB58_RS13905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPB58_RS13915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPB58_RS13920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPB58_RS13925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPB58_RS13930	COG1610	YqeY-like protein
EPB58_RS13935	COG0358	DNA primase activity
EPB58_RS13995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS13995	COG2213	PTS system mannitol-specific
EPB58_RS14005	COG3722	fumarate hydratase activity
EPB58_RS14010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB58_RS14015	COG5002	protein histidine kinase activity
EPB58_RS14035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPB58_RS14040	COG1349	DNA-binding transcription factor activity
EPB58_RS14050	COG0469	pyruvate kinase activity
EPB58_RS14060	COG3706	GGDEF domain
EPB58_RS14065	COG0440	acetolactate synthase activity
EPB58_RS14070	COG0028	Belongs to the TPP enzyme family
EPB58_RS14075	COG1022	Amp-dependent synthetase and ligase
EPB58_RS14080	COG0583	DNA-binding transcription factor activity
EPB58_RS14090	COG0671	phosphoesterase, PA-phosphatase related
EPB58_RS14105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPB58_RS14110	COG0473	3-isopropylmalate dehydrogenase activity
EPB58_RS14130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB58_RS14135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EPB58_RS14140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB58_RS14145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPB58_RS14150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPB58_RS14170	COG3610	response to peptide
EPB58_RS14175	COG2966	Psort location CytoplasmicMembrane, score
EPB58_RS14180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPB58_RS14190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPB58_RS14195	COG0142	geranyltranstransferase activity
EPB58_RS14235	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EPB58_RS14240	COG1178	ABC-type Fe3 transport system permease component
EPB58_RS14245	COG4143	(ABC) transporter
EPB58_RS14250	COG0163	prenyltransferase activity
EPB58_RS14255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB58_RS14265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPB58_RS14275	COG2105	PFAM AIG2 family protein
EPB58_RS14290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB58_RS14300	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EPB58_RS14315	COG1136	(ABC) transporter
EPB58_RS14335	COG0529	Catalyzes the synthesis of activated sulfate
EPB58_RS14340	COG0471	metal ion transport
EPB58_RS14340	COG3273	potassium ion transport
EPB58_RS14355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPB58_RS14355	COG1648	precorrin-2 dehydrogenase activity
EPB58_RS14360	COG0737	Belongs to the 5'-nucleotidase family
EPB58_RS14370	COG0513	Belongs to the DEAD box helicase family
EPB58_RS14375	COG2153	protein acetylation
EPB58_RS14390	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB58_RS14400	COG0203	ribosomal protein L17
EPB58_RS14405	COG0202	RNA polymerase activity
EPB58_RS14415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPB58_RS14420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPB58_RS14425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPB58_RS14430	COG0201	protein transport
EPB58_RS14435	COG0200	Binds to the 23S rRNA
EPB58_RS14440	COG1841	ribosomal large subunit assembly
EPB58_RS14455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPB58_RS14505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPB58_RS14525	COG0088	Forms part of the polypeptide exit tunnel
EPB58_RS14540	COG0254	rRNA binding
EPB58_RS14550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPB58_RS14555	COG1609	Transcriptional regulator
EPB58_RS14575	COG1575	Belongs to the MenA family. Type 1 subfamily
EPB58_RS14580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB58_RS14590	COG1494	fructose-1,6-bisphosphatase
EPB58_RS14620	COG0149	triose-phosphate isomerase activity
EPB58_RS14625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EPB58_RS14645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB58_RS14660	COG1482	cell wall glycoprotein biosynthetic process
EPB58_RS14680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB58_RS14685	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EPB58_RS14780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB58_RS14790	COG1560	Kdo2-lipid A biosynthetic process
EPB58_RS14800	COG0859	PFAM glycosyl transferase family 9
EPB58_RS14805	COG1519	Transferase
EPB58_RS14810	COG0471	metal ion transport
EPB58_RS14810	COG3273	potassium ion transport
EPB58_RS14815	COG0175	sulfate reduction
EPB58_RS14820	COG0529	Catalyzes the synthesis of activated sulfate
EPB58_RS14825	COG2895	sulfate adenylyltransferase (ATP) activity
EPB58_RS14850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EPB58_RS14860	COG3642	lipopolysaccharide core region biosynthetic process
EPB58_RS14865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB58_RS14870	COG0859	PFAM glycosyl transferase family 9
EPB58_RS14875	COG0463	Glycosyl transferase, family 2
EPB58_RS14890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPB58_RS14905	COG2194	sulfuric ester hydrolase activity
EPB58_RS14925	COG0840	transmembrane signaling receptor activity
EPB58_RS14930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPB58_RS14940	COG1560	Kdo2-lipid A biosynthetic process
EPB58_RS14945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPB58_RS14950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EPB58_RS14955	COG1561	YicC-like family, N-terminal region
EPB58_RS14960	COG0745	RESPONSE REGULATOR receiver
EPB58_RS14985	COG4608	Belongs to the ABC transporter superfamily
EPB58_RS14990	COG0444	Belongs to the ABC transporter superfamily
EPB58_RS14995	COG0747	negative chemotaxis
EPB58_RS15000	COG4239	(ABC) transporter, permease
EPB58_RS15005	COG4174	ABC transporter (Permease)
EPB58_RS15030	COG0811	peptide transport
EPB58_RS15035	COG0848	biopolymer transport protein
EPB58_RS15050	COG0194	GDP metabolic process
EPB58_RS15055	COG1758	RNA polymerase activity
EPB58_RS15060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB58_RS15065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB58_RS15070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPB58_RS15080	COG2233	PERMEase
EPB58_RS15095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB58_RS15105	COG2183	response to ionizing radiation
EPB58_RS15120	COG1040	competence protein
EPB58_RS15130	COG0494	nUDIX hydrolase
EPB58_RS15135	COG1218	3'(2'),5'-bisphosphate nucleotidase
EPB58_RS15145	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB58_RS15150	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB58_RS15155	COG3156	type II secretion system protein K
EPB58_RS15160	COG4795	General secretion pathway protein
EPB58_RS15165	COG2165	general secretion pathway protein
EPB58_RS15170	COG2165	general secretion pathway protein
EPB58_RS15175	COG2165	general secretion pathway protein
EPB58_RS15180	COG1459	type II secretion system
EPB58_RS15185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB58_RS15195	COG3031	protein transport across the cell outer membrane
EPB58_RS15200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPB58_RS15220	COG0456	acetyltransferase
EPB58_RS15225	COG1490	D-aminoacyl-tRNA deacylase activity
EPB58_RS15245	COG1217	gtp-binding protein TYPA
EPB58_RS15250	COG0174	glutamine synthetase
EPB58_RS15260	COG3852	Histidine kinase
EPB58_RS15265	COG2204	response regulator
EPB58_RS15275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB58_RS15305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EPB58_RS15315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB58_RS15315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB58_RS15335	COG0084	hydrolase, TatD family'
EPB58_RS15340	COG0805	protein transport
EPB58_RS15345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB58_RS15360	COG3165	ubiquinone biosynthetic process from chorismate
EPB58_RS15370	COG1322	Protein conserved in bacteria
EPB58_RS15390	COG2081	HI0933 family
EPB58_RS15400	COG1528	Iron-storage protein
EPB58_RS15405	COG0589	response to stress
EPB58_RS15425	COG5001	Diguanylate cyclase
EPB58_RS15425	COG5002	protein histidine kinase activity
EPB58_RS15430	COG1522	sequence-specific DNA binding
EPB58_RS15440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPB58_RS15450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB58_RS15455	COG0800	Aldolase
EPB58_RS15460	COG2610	gluconate transmembrane transporter activity
EPB58_RS15465	COG3265	gluconokinase activity
EPB58_RS15470	COG0129	dihydroxy-acid dehydratase activity
EPB58_RS15480	COG2076	Multidrug Resistance protein
EPB58_RS15485	COG0583	DNA-binding transcription factor activity
EPB58_RS15490	COG1609	Transcriptional regulator
EPB58_RS15525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB58_RS15530	COG0601	transmembrane transport
EPB58_RS15535	COG0747	negative chemotaxis
EPB58_RS15540	COG4172	Belongs to the ABC transporter superfamily
EPB58_RS15550	COG0546	phosphoglycolate phosphatase activity
EPB58_RS15590	COG1309	transcriptional regulator
EPB58_RS15595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB58_RS15600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB58_RS15610	COG2960	long-chain fatty acid transporting porin activity
EPB58_RS15615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPB58_RS15620	COG0583	DNA-binding transcription factor activity
EPB58_RS15670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPB58_RS15680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPB58_RS15695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPB58_RS15700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPB58_RS15705	COG0551	DNA topoisomerase type I activity
EPB58_RS15715	COG0758	DNA mediated transformation
EPB58_RS15725	COG0242	peptide deformylase activity
EPB58_RS15735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPB58_RS15735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB58_RS15740	COG0569	domain protein
EPB58_RS15745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB58_RS15755	COG1272	protein, Hemolysin III
EPB58_RS15760	COG4326	sporulation control protein
EPB58_RS15770	COG3084	Protein conserved in bacteria
EPB58_RS15780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPB58_RS15785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB58_RS15790	COG0204	Acyl-transferase
EPB58_RS15800	COG3706	GGDEF domain
EPB58_RS15805	COG0606	chelatase, subunit chli
EPB58_RS15815	COG3978	acetolactate synthase activity
EPB58_RS15820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPB58_RS15825	COG0129	dihydroxy-acid dehydratase activity
EPB58_RS15835	COG0583	DNA-binding transcription factor activity
EPB58_RS15840	COG2814	Major facilitator Superfamily
EPB58_RS15850	COG0765	amino acid transport
EPB58_RS15860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPB58_RS15870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPB58_RS15895	COG0356	it plays a direct role in the translocation of protons across the membrane
EPB58_RS15900	COG3312	ion transport
EPB58_RS15905	COG1475	DNA binding
EPB58_RS15910	COG1192	Involved in chromosome partitioning
EPB58_RS15920	COG0445	tRNA wobble uridine modification
EPB58_RS15925	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB58_RS15955	COG1126	abc transporter atp-binding protein
EPB58_RS15980	COG0592	DNA-directed DNA polymerase activity
EPB58_RS15990	COG0187	DNA topoisomerase II activity
EPB58_RS15995	COG0071	Belongs to the small heat shock protein (HSP20) family
EPB58_RS16000	COG3977	Valine--pyruvate aminotransferase
EPB58_RS16005	COG0366	Alpha amylase catalytic
EPB58_RS16020	COG2119	membrane
EPB58_RS16030	COG0425	Belongs to the sulfur carrier protein TusA family
EPB58_RS16045	COG0604	alcohol dehydrogenase
EPB58_RS16050	COG0183	Belongs to the thiolase family
EPB58_RS16060	COG1739	Uncharacterized protein family UPF0029
EPB58_RS16065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB58_RS16115	COG2132	Multicopper oxidase
EPB58_RS16135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB58_RS16140	COG2104	thiamine diphosphate biosynthetic process
EPB58_RS16155	COG0006	proline dipeptidase activity
EPB58_RS16155	COG0006	proline dipeptidase activity
EPB58_RS16165	COG2814	Major facilitator Superfamily
EPB58_RS16185	COG3220	belongs to the UPF0276 family
EPB58_RS16195	COG0210	DNA helicase
EPB58_RS16205	COG0405	Gamma-glutamyltransferase
EPB58_RS16210	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS16220	COG2962	Rard protein
EPB58_RS16225	COG0514	ATP-dependent DNA helicase (RecQ)
EPB58_RS16235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EPB58_RS16250	COG3118	belongs to the thioredoxin family
EPB58_RS16265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EPB58_RS16270	COG0633	Ferredoxin
EPB58_RS16320	COG2959	enzyme of heme biosynthesis
EPB58_RS16325	COG1587	Uroporphyrinogen-III synthase
EPB58_RS16335	COG3072	Adenylate cyclase
EPB58_RS16350	COG0019	diaminopimelate decarboxylase activity
EPB58_RS16370	COG1011	Hydrolase
EPB58_RS16375	COG2199	diguanylate cyclase activity
EPB58_RS16375	COG3287	FIST C domain
EPB58_RS16375	COG2200	EAL domain
EPB58_RS16380	COG3148	PFAM DTW domain containing protein
EPB58_RS16395	COG0561	phosphatase activity
EPB58_RS16400	COG2267	carboxylic ester hydrolase activity
EPB58_RS16405	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS16410	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB58_RS16415	COG0640	Transcriptional regulator
EPB58_RS16420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB58_RS16470	COG2095	MarC family integral membrane protein
EPB58_RS16480	COG0742	ribosomal rna small subunit methyltransferase
EPB58_RS16485	COG0552	protein localization to endoplasmic reticulum
EPB58_RS16490	COG2884	Cell division ATP-binding protein ftsE
EPB58_RS16495	COG2177	Part of the ABC transporter FtsEX involved in
EPB58_RS16510	COG0705	Rhomboid family
EPB58_RS16515	COG1580	Controls the rotational direction of flagella during chemotaxis
EPB58_RS16520	COG3161	chorismate lyase activity
EPB58_RS16530	COG2937	Belongs to the GPAT DAPAT family
EPB58_RS16545	COG0534	Mate efflux family protein
EPB58_RS16550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB58_RS16605	COG2003	Belongs to the UPF0758 family
EPB58_RS16610	COG3311	Transcriptional regulator
EPB58_RS16630	COG0464	growth
EPB58_RS16640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB58_RS16735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB58_RS16745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPB58_RS16790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB58_RS16795	COG0250	Participates in transcription elongation, termination and antitermination
EPB58_RS16810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPB58_RS16830	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EPB58_RS16835	COG2816	NAD+ diphosphatase activity
EPB58_RS16855	COG1573	uracil-dna glycosylase
EPB58_RS16865	COG3068	Protein conserved in bacteria
EPB58_RS16870	COG1253	flavin adenine dinucleotide binding
EPB58_RS16885	COG0151	Belongs to the GarS family
EPB58_RS16895	COG0789	Transcriptional regulator
EPB58_RS16900	COG3710	Transcriptional regulator
EPB58_RS16905	COG0531	amino acid
EPB58_RS16910	COG1982	Orn Lys Arg decarboxylase major
EPB58_RS16960	COG2199	diguanylate cyclase activity
EPB58_RS16965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EPB58_RS16970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB58_RS16985	COG0439	Biotin carboxylase
EPB58_RS16990	COG0511	ligase activity, forming carbon-carbon bonds
EPB58_RS16995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPB58_RS17000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB58_RS17015	COG2814	Major facilitator Superfamily
EPB58_RS17020	COG0784	Response regulator, receiver
EPB58_RS17020	COG2198	Histidine kinase
EPB58_RS17020	COG2205	protein histidine kinase activity
EPB58_RS17040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB58_RS17050	COG2095	MarC family integral membrane protein
EPB58_RS17060	COG4232	protein-disulfide reductase activity
EPB58_RS17065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB58_RS17070	COG1027	Aspartate ammonia-lyase
EPB58_RS17080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPB58_RS17085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EPB58_RS17090	COG2205	protein histidine kinase activity
EPB58_RS17095	COG0745	RESPONSE REGULATOR receiver
EPB58_RS17100	COG3678	ATP-independent chaperone mediated protein folding
EPB58_RS17105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EPB58_RS17115	COG0534	Mate efflux family protein
EPB58_RS17140	COG1509	lysine 2,3-aminomutase activity
EPB58_RS17170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB58_RS17175	COG1053	succinate dehydrogenase
EPB58_RS17200	COG4942	peptidase
EPB58_RS17205	COG1045	serine acetyltransferase
EPB58_RS17215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EPB58_RS17220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB58_RS17225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPB58_RS17235	COG0840	transmembrane signaling receptor activity
EPB58_RS17240	COG0471	metal ion transport
EPB58_RS17250	COG1162	GTPase activity
EPB58_RS17320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPB58_RS17325	COG0802	atpase or kinase
EPB58_RS17335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPB58_RS17350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPB58_RS17355	COG0330	HflC and HflK could
EPB58_RS17360	COG0330	HflC and HflK could
EPB58_RS17365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EPB58_RS17370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB58_RS17380	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EPB58_RS17385	COG1017	nitric oxide dioxygenase activity
EPB58_RS17385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB58_RS17395	COG0557	exoribonuclease II activity
EPB58_RS17400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB58_RS17405	COG0546	phosphoglycolate phosphatase activity
EPB58_RS17430	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB58_RS17435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPB58_RS17455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB58_RS17460	COG3954	Phosphoribulokinase
EPB58_RS17470	COG0429	hydrolase of the alpha beta-hydrolase fold
EPB58_RS17480	COG0488	(ABC) transporter
EPB58_RS17490	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB58_RS17505	COG1047	Peptidyl-prolyl cis-trans
EPB58_RS17515	COG1446	asparaginase
EPB58_RS17530	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB58_RS17535	COG2964	Protein conserved in bacteria
EPB58_RS17540	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EPB58_RS17545	COG2923	Belongs to the DsrF TusC family
EPB58_RS17550	COG2168	tRNA wobble position uridine thiolation
EPB58_RS17565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB58_RS17575	COG2906	2 iron, 2 sulfur cluster binding
EPB58_RS17585	COG0281	malic enzyme
EPB58_RS17595	COG0626	cystathionine gamma-synthase activity
EPB58_RS17600	COG0527	aspartate kinase activity
EPB58_RS17600	COG0460	homoserine dehydrogenase
EPB58_RS17605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPB58_RS17615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EPB58_RS17625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPB58_RS17640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB58_RS17640	COG0165	Argininosuccinate lyase
EPB58_RS17655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB58_RS17660	COG0678	peroxiredoxin activity
EPB58_RS17660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB58_RS17670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPB58_RS17715	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EPB58_RS17720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPB58_RS17725	COG0360	Binds together with S18 to 16S ribosomal RNA
EPB58_RS17745	COG0305	Participates in initiation and elongation during chromosome replication
EPB58_RS17750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB58_RS17760	COG0432	Pfam Uncharacterised protein family UPF0047
EPB58_RS17775	COG0735	belongs to the Fur family
EPB58_RS17820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB58_RS17840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB58_RS17905	COG0646	methionine synthase
EPB58_RS17905	COG1410	methionine synthase
EPB58_RS17910	COG0527	aspartate kinase activity
EPB58_RS17915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPB58_RS17925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPB58_RS17940	COG0629	single-stranded DNA binding
EPB58_RS17945	COG2200	EAL domain
EPB58_RS17945	COG2199	diguanylate cyclase activity
EPB58_RS17970	COG3409	Peptidoglycan-binding domain 1 protein
EPB58_RS17970	COG3267	Type II secretory pathway component ExeA
EPB58_RS17980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB58_RS17985	COG1459	type II secretion system
EPB58_RS17995	COG2165	general secretion pathway protein
EPB58_RS18030	COG1077	Cell shape determining protein MreB Mrl
EPB58_RS18035	COG1792	Involved in formation and maintenance of cell shape
EPB58_RS18040	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPB58_RS18045	COG0424	maF-like protein
EPB58_RS18055	COG3164	Protein of unknown function
EPB58_RS18060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB58_RS18065	COG0312	modulator of DNA gyrase
EPB58_RS18070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EPB58_RS18085	COG0564	pseudouridine synthase activity
EPB58_RS18090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB58_RS18100	COG0312	modulator of DNA gyrase
EPB58_RS18105	COG2239	Acts as a magnesium transporter
EPB58_RS18110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS18120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB58_RS18125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB58_RS18135	COG1137	ATPase activity
EPB58_RS18140	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPB58_RS18150	COG0517	IMP dehydrogenase activity
EPB58_RS18150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPB58_RS18160	COG1127	ABC transporter
EPB58_RS18165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPB58_RS18170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB58_RS18175	COG2854	intermembrane phospholipid transfer
EPB58_RS18185	COG5007	Belongs to the BolA IbaG family
EPB58_RS18195	COG0204	Acyl-transferase
EPB58_RS18200	COG0251	oxidation-reduction process
EPB58_RS18240	COG0456	acetyltransferase
EPB58_RS18250	COG0525	valine-tRNA ligase activity
EPB58_RS18255	COG2927	DNA polymerase III (CHI subunit)
EPB58_RS18265	COG0795	lipopolysaccharide-transporting ATPase activity
EPB58_RS18270	COG0795	lipopolysaccharide-transporting ATPase activity
EPB58_RS18280	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS18300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPB58_RS18310	COG1447	Phosphotransferase system cellobiose-specific component IIA
EPB58_RS18315	COG1486	melibiose metabolic process
EPB58_RS18330	COG3437	response regulator, receiver
EPB58_RS18380	COG1012	belongs to the aldehyde dehydrogenase family
EPB58_RS18480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPB58_RS18485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPB58_RS18500	COG0762	integral membrane protein
EPB58_RS18505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EPB58_RS18510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPB58_RS18525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPB58_RS18530	COG1678	Uncharacterized ACR, COG1678
EPB58_RS18535	COG0189	ligase activity
EPB58_RS18540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPB58_RS18545	COG2356	endonuclease I
EPB58_RS18565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB58_RS18585	COG0191	fructose-bisphosphate aldolase activity
EPB58_RS18590	COG0668	transmembrane transport
EPB58_RS18605	COG0583	DNA-binding transcription factor activity
EPB58_RS18615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB58_RS18625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPB58_RS18635	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EPB58_RS18650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB58_RS18655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB58_RS18675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EPB58_RS18685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPB58_RS18695	COG1595	DNA-templated transcription, initiation
EPB58_RS18710	COG3086	response to oxidative stress
EPB58_RS18730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPB58_RS18735	COG1381	Involved in DNA repair and RecF pathway recombination
EPB58_RS18740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPB58_RS18760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB58_RS18765	COG3956	TIGRFAM MazG family protein
EPB58_RS18775	COG0148	phosphopyruvate hydratase activity
EPB58_RS18785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPB58_RS18815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPB58_RS18825	COG1546	Belongs to the CinA family
EPB58_RS18830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPB58_RS18845	COG0527	aspartate kinase activity
EPB58_RS18905	COG3630	sodium ion export across plasma membrane
EPB58_RS18910	COG0511	ligase activity, forming carbon-carbon bonds
EPB58_RS18910	COG5016	pyruvate
EPB58_RS18915	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPB58_RS18925	COG1238	metal cluster binding
EPB58_RS18930	COG0612	Peptidase, M16
EPB58_RS18950	COG4536	flavin adenine dinucleotide binding
EPB58_RS18955	COG4137	Cytochrome C assembly protein
EPB58_RS18960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPB58_RS18985	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EPB58_RS18990	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EPB58_RS18995	COG0237	dephospho-CoA kinase activity
EPB58_RS19005	COG1459	type II secretion system
EPB58_RS19010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB58_RS19025	COG3023	N-Acetylmuramoyl-L-alanine amidase
EPB58_RS19030	COG2186	Transcriptional regulator
EPB58_RS19035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EPB58_RS19040	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB58_RS19045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB58_RS19060	COG0288	reversible hydration of carbon dioxide
EPB58_RS19065	COG0659	secondary active sulfate transmembrane transporter activity
EPB58_RS19070	COG1131	(ABC) transporter
EPB58_RS19075	COG0842	Transport permease protein
EPB58_RS19080	COG1560	Kdo2-lipid A biosynthetic process
EPB58_RS19095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB58_RS19110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB58_RS19125	COG1643	Atp-dependent helicase
EPB58_RS19130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB58_RS19135	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPB58_RS19140	COG1049	propionate catabolic process, 2-methylcitrate cycle
EPB58_RS19155	COG0004	ammonium transporteR
EPB58_RS19160	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB58_RS19170	COG3842	ATPase activity
EPB58_RS19175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB58_RS19190	COG2971	BadF BadG BcrA BcrD
EPB58_RS19200	COG4608	Belongs to the ABC transporter superfamily
EPB58_RS19205	COG0444	Belongs to the ABC transporter superfamily
EPB58_RS19210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB58_RS19220	COG0747	negative chemotaxis
EPB58_RS19225	COG2198	Histidine kinase
EPB58_RS19225	COG2205	protein histidine kinase activity
EPB58_RS19225	COG0784	Response regulator, receiver
EPB58_RS19225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB58_RS19240	COG0628	permease
EPB58_RS19250	COG0316	Belongs to the HesB IscA family
EPB58_RS19265	COG0739	heme binding
EPB58_RS19270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB58_RS19280	COG2027	D-alanyl-D-alanine carboxypeptidase
EPB58_RS19285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB58_RS19290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB58_RS19295	COG1534	Rna-binding protein
EPB58_RS19305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPB58_RS19310	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPB58_RS19320	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB58_RS19340	COG0195	Participates in both transcription termination and antitermination
EPB58_RS19360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPB58_RS19380	COG0534	Mate efflux family protein
EPB58_RS19385	COG0826	peptidase U32
EPB58_RS19390	COG0826	peptidase U32
EPB58_RS19400	COG3154	lipid carrier protein
EPB58_RS19405	COG3153	acetyltransferase
EPB58_RS19425	COG3706	GGDEF domain
EPB58_RS19430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EPB58_RS19435	COG0084	hydrolase, TatD family'
EPB58_RS19440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB58_RS19450	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EPB58_RS19460	COG0813	purine-nucleoside phosphorylase activity
EPB58_RS19470	COG0560	Phosphoserine phosphatase
EPB58_RS19480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPB58_RS19485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB58_RS19490	COG0583	DNA-binding transcription factor activity
EPB58_RS19500	COG1022	Amp-dependent synthetase and ligase
EPB58_RS19505	COG2169	Transcriptional regulator
EPB58_RS19530	COG4964	Belongs to the GSP D family
EPB58_RS19590	COG0583	DNA-binding transcription factor activity
EPB58_RS19595	COG0531	amino acid
EPB58_RS19600	COG2731	YhcH YjgK YiaL family protein
EPB58_RS19605	COG3250	beta-galactosidase activity
EPB58_RS19610	COG1609	Transcriptional regulator
EPB58_RS19620	COG0768	penicillin binding
EPB58_RS19625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPB58_RS19640	COG2017	converts alpha-aldose to the beta-anomer
EPB58_RS19650	COG1263	PTS System
EPB58_RS19650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS19660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB58_RS19680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPB58_RS19685	COG1349	DNA-binding transcription factor activity
EPB58_RS19695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB58_RS19705	COG2271	Major facilitator Superfamily
EPB58_RS19710	COG0584	glycerophosphoryl diester phosphodiesterase
EPB58_RS19715	COG2171	N-acyltransferase activity
EPB58_RS19730	COG3141	response to X-ray
EPB58_RS19755	COG1074	ATP-dependent DNA helicase activity
EPB58_RS19760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB58_RS19780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB58_RS19780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB58_RS19790	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EPB58_RS19795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPB58_RS19800	COG2166	iron-sulfur cluster assembly
EPB58_RS19805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPB58_RS19810	COG0693	protein deglycase activity
EPB58_RS19815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EPB58_RS19820	COG3248	Nucleoside-binding outer membrane protein
EPB58_RS19840	COG1595	DNA-templated transcription, initiation
EPB58_RS19870	COG0271	Belongs to the BolA IbaG family
EPB58_RS19895	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB58_RS19905	COG1477	protein flavinylation
EPB58_RS19920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPB58_RS19925	COG0514	ATP-dependent DNA helicase (RecQ)
EPB58_RS19930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB58_RS19945	COG0733	neurotransmitter:sodium symporter activity
EPB58_RS19970	COG1720	tRNA m6t6A37 methyltransferase activity
EPB58_RS19985	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB58_RS20010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB58_RS20045	COG3098	single-species biofilm formation
EPB58_RS20050	COG0564	pseudouridine synthase activity
EPB58_RS20065	COG0024	Methionine aminopeptidase
EPB58_RS20090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPB58_RS20095	COG0575	Belongs to the CDS family
EPB58_RS20105	COG0750	zinc metalloprotease
EPB58_RS20115	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EPB58_RS20120	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB58_RS20145	COG0587	DNA-directed DNA polymerase activity
EPB58_RS20165	COG0347	Belongs to the P(II) protein family
EPB58_RS20180	COG0741	lytic transglycosylase activity
EPB58_RS20180	COG1388	LysM domain
EPB58_RS20190	COG2226	methyltransferase
EPB58_RS20200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPB58_RS20225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB58_RS20230	COG0121	glutamine amidotransferase
EPB58_RS20235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPB58_RS20240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EPB58_RS20245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPB58_RS20250	COG2233	PERMEase
EPB58_RS20270	COG1393	Belongs to the ArsC family
EPB58_RS20275	COG4783	chaperone-mediated protein folding
EPB58_RS20290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPB58_RS20295	COG2716	regulation of RNA biosynthetic process
EPB58_RS20300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPB58_RS20305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EPB58_RS20325	COG1393	Belongs to the ArsC family
EPB58_RS20350	COG2837	iron assimilation
EPB58_RS20355	COG2169	Transcriptional regulator
EPB58_RS20360	COG1486	melibiose metabolic process
EPB58_RS20365	COG2211	Major facilitator Superfamily
EPB58_RS20370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB58_RS20380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB58_RS20385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB58_RS20390	COG1334	flagellar protein FlaG
EPB58_RS20395	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB58_RS20405	COG1516	flagellar protein fliS
EPB58_RS20425	COG1677	Flagellar hook-basal body complex protein FliE
EPB58_RS20435	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPB58_RS20490	COG1987	bacterial-type flagellum assembly
EPB58_RS20495	COG1684	flagellar biosynthetic protein fliR
EPB58_RS20530	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EPB58_RS20535	COG0643	Histidine kinase
EPB58_RS20535	COG0784	Response regulator, receiver
EPB58_RS20535	COG2198	Histidine kinase
EPB58_RS20540	COG2201	protein-glutamate methylesterase activity
EPB58_RS20545	COG1192	Involved in chromosome partitioning
EPB58_RS20555	COG0835	chemotaxis
EPB58_RS20565	COG4133	protoheme IX ABC transporter activity
EPB58_RS20570	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB58_RS20575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB58_RS20590	COG1138	Cytochrome C-type biogenesis protein
EPB58_RS20595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPB58_RS20605	COG4235	cytochrome complex assembly
EPB58_RS20605	COG3088	subunit of a heme lyase
EPB58_RS20610	COG2853	Lipoprotein
EPB58_RS20615	COG2067	long-chain fatty acid transport protein
EPB58_RS20620	COG2067	long-chain fatty acid transport protein
EPB58_RS20635	COG0183	Belongs to the thiolase family
EPB58_RS20655	COG2062	phosphohistidine phosphatase, SixA
EPB58_RS20660	COG2840	Smr protein MutS2
EPB58_RS20665	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB58_RS20675	COG2860	membrane
EPB58_RS20680	COG3101	peptidyl-lysine hydroxylation
EPB58_RS20700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB58_RS20705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB58_RS20710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB58_RS20730	COG0285	dihydrofolate synthase activity
EPB58_RS20735	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EPB58_RS20740	COG1286	toxin biosynthetic process
EPB58_RS20745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPB58_RS20750	COG0583	DNA-binding transcription factor activity
EPB58_RS20755	COG0745	RESPONSE REGULATOR receiver
EPB58_RS20765	COG2832	Protein of unknown function (DUF454)
EPB58_RS20775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPB58_RS20785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPB58_RS20805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB58_RS20810	COG0814	amino acid
EPB58_RS20815	COG0251	oxidation-reduction process
EPB58_RS20825	COG2964	Protein conserved in bacteria
EPB58_RS20835	COG2983	Belongs to the UPF0260 family
EPB58_RS20845	COG2261	transglycosylase associated protein
EPB58_RS20850	COG0668	transmembrane transport
EPB58_RS20855	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPB58_RS20860	COG0346	lactoylglutathione lyase activity
EPB58_RS20870	COG1785	Belongs to the alkaline phosphatase family
EPB58_RS20890	COG2226	methyltransferase
EPB58_RS20910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB58_RS20915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB58_RS20925	COG3139	Protein of unknown function (DUF1315)
EPB58_RS20930	COG0252	asparaginase activity
EPB58_RS20935	COG0616	signal peptide processing
EPB58_RS20940	COG1902	pentaerythritol trinitrate reductase activity
EPB58_RS20940	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB58_RS20950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB58_RS20965	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPB58_RS20975	COG3083	sulfuric ester hydrolase activity
EPB58_RS21000	COG1757	Na H antiporter
EPB58_RS21005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB58_RS21010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB58_RS21015	COG2095	MarC family integral membrane protein
EPB58_RS21020	COG1012	belongs to the aldehyde dehydrogenase family
EPB58_RS21020	COG1454	alcohol dehydrogenase
EPB58_RS21040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPB58_RS21050	COG2056	Na+-H+ antiporter family
EPB58_RS21060	COG2885	chlorophyll binding
EPB58_RS21070	COG0346	lactoylglutathione lyase activity
EPB58_RS21075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPB58_RS21080	COG4660	Part of a membrane complex involved in electron transport
EPB58_RS21085	COG4659	FMN binding
EPB58_RS21090	COG4658	electron transport chain
EPB58_RS21095	COG4656	Part of a membrane complex involved in electron transport
EPB58_RS21105	COG4657	Part of a membrane complex involved in electron transport
EPB58_RS21110	COG1882	Formate acetyltransferase
EPB58_RS21120	COG0556	nucleotide-excision repair
EPB58_RS21135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EPB58_RS21140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPB58_RS21145	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPB58_RS21155	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EPB58_RS21160	COG0314	molybdopterin synthase activity
EPB58_RS21170	COG0601	transmembrane transport
EPB58_RS21175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB58_RS21180	COG0444	Belongs to the ABC transporter superfamily
EPB58_RS21190	COG0435	Glutathione S-transferase
EPB58_RS21195	COG3174	membrane
EPB58_RS21200	COG0857	belongs to the CobB CobQ family
EPB58_RS21200	COG0280	phosphate acetyltransferase
EPB58_RS21220	COG4120	Belongs to the binding-protein-dependent transport system permease family
EPB58_RS21225	COG1122	ATPase activity
EPB58_RS21230	COG0366	Alpha amylase catalytic
EPB58_RS21235	COG3706	GGDEF domain
EPB58_RS21240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB58_RS21245	COG0653	protein targeting
EPB58_RS21250	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EPB58_RS21260	COG2186	Transcriptional regulator
EPB58_RS21290	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EPB58_RS21295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPB58_RS21300	COG0659	secondary active sulfate transmembrane transporter activity
EPB58_RS21305	COG1530	ribonuclease E activity
EPB58_RS21310	COG0564	pseudouridine synthase activity
EPB58_RS21315	COG0424	maF-like protein
EPB58_RS21320	COG1399	metal-binding, possibly nucleic acid-binding protein
EPB58_RS21335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB58_RS21365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPB58_RS21380	COG0084	hydrolase, TatD family'
EPB58_RS21385	COG1263	PTS System
EPB58_RS21385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB58_RS21400	COG0733	neurotransmitter:sodium symporter activity
EPB58_RS21415	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB58_RS21425	COG1940	carbohydrate kinase activity
EPB58_RS21430	COG0835	chemotaxis
EPB58_RS21430	COG0784	Response regulator, receiver
EPB58_RS21450	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS21455	COG0616	signal peptide processing
EPB58_RS21465	COG0539	negative regulation of cytoplasmic translation
EPB58_RS21475	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EPB58_RS21480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EPB58_RS21490	COG4166	transmembrane transport
EPB58_RS21545	COG3009	Protein conserved in bacteria
EPB58_RS21550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB58_RS21550	COG3008	intermembrane lipid transfer
EPB58_RS21555	COG2995	paraquat-inducible protein a
EPB58_RS21570	COG4232	protein-disulfide reductase activity
EPB58_RS21575	COG3118	belongs to the thioredoxin family
EPB58_RS21600	COG3153	acetyltransferase
EPB58_RS21625	COG0577	efflux transmembrane transporter activity
EPB58_RS21635	COG1136	(ABC) transporter
EPB58_RS21635	COG0577	efflux transmembrane transporter activity
EPB58_RS21680	COG1846	Transcriptional regulator
EPB58_RS21715	COG5002	protein histidine kinase activity
EPB58_RS21715	COG3850	Histidine kinase
EPB58_RS21720	COG0745	RESPONSE REGULATOR receiver
EPB58_RS21725	COG0463	Glycosyl transferase, family 2
EPB58_RS21730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPB58_RS21740	COG0840	transmembrane signaling receptor activity
EPB58_RS21745	COG2964	Protein conserved in bacteria
EPB58_RS21760	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB58_RS21765	COG1032	radical SAM domain protein
EPB58_RS21770	COG5001	Diguanylate cyclase
EPB58_RS21770	COG1716	ATPase activity
EPB58_RS21785	COG0583	DNA-binding transcription factor activity
EPB58_RS21800	COG2350	Protein conserved in bacteria
EPB58_RS21805	COG1607	acyl-coa hydrolase
EPB58_RS21830	COG1301	dicarboxylic acid transport
EPB58_RS21835	COG0159	tryptophan synthase activity
EPB58_RS21845	COG0135	phosphoribosylanthranilate isomerase activity
EPB58_RS21845	COG0134	indole-3-glycerol-phosphate synthase activity
EPB58_RS21855	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB58_RS21860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB58_RS21870	COG0613	PHP domain protein
EPB58_RS21875	COG0009	L-threonylcarbamoyladenylate synthase
EPB58_RS21885	COG1187	pseudouridine synthase activity
EPB58_RS21910	COG2197	response regulator
EPB58_RS21915	COG0322	excinuclease ABC activity
EPB58_RS21955	COG0019	diaminopimelate decarboxylase activity
EPB58_RS21980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB58_RS21985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB58_RS21990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB58_RS22010	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EPB58_RS22020	COG0437	4 iron, 4 sulfur cluster binding
EPB58_RS22025	COG3301	Polysulphide reductase, NrfD
EPB58_RS22030	COG1138	Cytochrome C-type biogenesis protein
EPB58_RS22040	COG4235	cytochrome complex assembly
EPB58_RS22040	COG3088	subunit of a heme lyase
EPB58_RS22050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB58_RS22075	COG2989	Protein conserved in bacteria
EPB58_RS22080	COG3108	Peptidase M15
EPB58_RS22085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB58_RS22100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EPB58_RS22125	COG1846	Transcriptional regulator
EPB58_RS22130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB58_RS22135	COG0840	transmembrane signaling receptor activity
EPB58_RS22155	COG1448	Aminotransferase
EPB58_RS22160	COG2770	Histidine kinase
EPB58_RS22160	COG3437	response regulator, receiver
EPB58_RS22175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB58_RS22190	COG0017	Asparaginyl-tRNA synthetase
EPB58_RS22195	COG0840	transmembrane signaling receptor activity
EPB58_RS22200	COG0720	synthase
EPB58_RS22205	COG2197	response regulator
EPB58_RS22215	COG3300	MHYT domain
EPB58_RS22215	COG5001	Diguanylate cyclase
EPB58_RS22220	COG1760	l-serine dehydratase
EPB58_RS22225	COG0814	amino acid
EPB58_RS22240	COG2205	protein histidine kinase activity
EPB58_RS22240	COG0784	Response regulator, receiver
EPB58_RS22245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB58_RS22260	COG3106	COG3106 Predicted ATPase
EPB58_RS22275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB58_RS22740	COG0791	NLP P60 protein
EPB58_RS23080	COG0519	Catalyzes the synthesis of GMP from XMP
EPB58_RS23115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPB58_RS23150	COG0277	FAD linked oxidase domain protein
EPB58_RS23150	COG0247	lactate metabolic process
EPB58_RS23165	COG2986	histidine ammonia-lyase
EPB58_RS23175	COG0010	Belongs to the arginase family
EPB58_RS23185	COG2188	Transcriptional regulator
EPB58_RS23210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPB58_RS23220	COG0251	oxidation-reduction process
EPB58_RS23275	COG0072	phenylalanine-tRNA ligase activity
EPB58_RS23275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB58_RS23335	COG1346	cytolysis
EPB58_RS23345	COG2925	Exonuclease
EPB58_RS23350	COG0662	Cupin 2, conserved barrel domain protein
EPB58_RS23355	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS23360	COG1794	racemase activity, acting on amino acids and derivatives
EPB58_RS23365	COG0583	DNA-binding transcription factor activity
EPB58_RS23375	COG1823	symporter activity
EPB58_RS23380	COG0702	epimerase
EPB58_RS23385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPB58_RS23395	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EPB58_RS23405	COG2062	phosphohistidine phosphatase, SixA
EPB58_RS23420	COG4139	cobalamin transport
EPB58_RS23475	COG0583	DNA-binding transcription factor activity
EPB58_RS23500	COG2165	general secretion pathway protein
EPB58_RS23505	COG1451	nucleotide metabolic process
EPB58_RS23535	COG3938	Belongs to the proline racemase family
EPB58_RS23540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB58_RS23550	COG2423	ornithine cyclodeaminase activity
EPB58_RS23555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPB58_RS23560	COG3842	ATPase activity
EPB58_RS23565	COG1176	ABC-type spermidine putrescine transport system, permease component I
EPB58_RS23570	COG1177	transmembrane transport
EPB58_RS23575	COG0813	purine-nucleoside phosphorylase activity
EPB58_RS23595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB58_RS23600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB58_RS23610	COG0745	RESPONSE REGULATOR receiver
EPB58_RS23625	COG3291	Pkd domain containing protein
EPB58_RS23645	COG0444	Belongs to the ABC transporter superfamily
EPB58_RS23650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB58_RS23655	COG0601	transmembrane transport
EPB58_RS23665	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB58_RS23680	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EPB58_RS23690	COG0625	glutathione transferase activity
EPB58_RS23735	COG1051	belongs to the nudix hydrolase family
EPB58_RS23775	COG4565	transcriptional regulatory protein
EPB58_RS23785	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPB58_RS23790	COG5016	pyruvate
EPB58_RS23790	COG0511	ligase activity, forming carbon-carbon bonds
EPB58_RS23795	COG3630	sodium ion export across plasma membrane
EPB58_RS23805	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EPB58_RS23815	COG2301	Belongs to the HpcH HpaI aldolase family
EPB58_RS23830	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EPB58_RS23860	COG3284	Transcriptional regulator
EPB58_RS23865	COG1012	belongs to the aldehyde dehydrogenase family
EPB58_RS23870	COG1115	amino acid carrier protein
EPB58_RS23905	COG1368	sulfuric ester hydrolase activity
EPB58_RS23920	COG0534	Mate efflux family protein
EPB58_RS23925	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EPB58_RS23935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB58_RS23940	COG0456	acetyltransferase
EPB58_RS23945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB58_RS23950	COG0662	Cupin 2, conserved barrel domain protein
EPB58_RS23955	COG0527	aspartate kinase activity
EPB58_RS23970	COG1858	cytochrome C peroxidase
EPB58_RS23980	COG0583	DNA-binding transcription factor activity
EPB58_RS23985	COG0702	epimerase
EPB58_RS24000	COG2186	Transcriptional regulator
EPB58_RS24030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EPB58_RS24035	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EPB58_RS24050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPB58_RS24055	COG1999	signal sequence binding
EPB58_RS24070	COG3005	denitrification pathway
EPB58_RS24085	COG0583	DNA-binding transcription factor activity
EPB58_RS24095	COG2814	Major facilitator Superfamily
EPB58_RS24100	COG0583	DNA-binding transcription factor activity
EPB58_RS24120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB58_RS24135	COG3290	protein histidine kinase activity
EPB58_RS24140	COG4565	transcriptional regulatory protein
EPB58_RS24145	COG4774	siderophore transport
EPB58_RS24155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPB58_RS24160	COG0363	glucosamine-6-phosphate deaminase activity
EPB58_RS24165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB58_RS24170	COG0589	response to stress
EPB58_RS24190	COG2207	Transcriptional regulator
EPB58_RS24215	COG4964	Belongs to the GSP D family
EPB58_RS24275	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EPB58_RS24285	COG0668	transmembrane transport
EPB58_RS24290	COG3247	response to pH
EPB58_RS24300	COG1846	Transcriptional regulator
EPB58_RS24320	COG0110	maltose O-acetyltransferase activity
EPB58_RS24335	COG3850	Histidine kinase
EPB58_RS24335	COG3437	response regulator, receiver
EPB58_RS24335	COG4999	Histidine kinase
EPB58_RS24335	COG2205	protein histidine kinase activity
EPB58_RS24340	COG5001	Diguanylate cyclase
EPB58_RS24340	COG3300	MHYT domain
EPB58_RS24380	COG1254	Belongs to the acylphosphatase family
EPB58_RS24385	COG2920	part of a sulfur-relay system
EPB58_RS24390	COG0670	Belongs to the BI1 family
EPB58_RS24395	COG1126	abc transporter atp-binding protein
EPB58_RS24400	COG0765	amino acid transport
EPB58_RS24405	COG4597	amino acid ABC transporter
EPB58_RS24410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB58_RS24425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB58_RS24450	COG3008	intermembrane lipid transfer
EPB58_RS24455	COG2995	paraquat-inducible protein a
EPB58_RS24460	COG1132	(ABC) transporter
EPB58_RS24465	COG1956	GAF domain-containing protein
EPB58_RS24470	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EPB58_RS24485	COG0308	aminopeptidase N
EPB58_RS24495	COG2902	Dehydrogenase
EPB58_RS24525	COG0488	(ABC) transporter
EPB58_RS24540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB58_RS24545	COG1067	ATP-dependent peptidase activity
EPB58_RS24575	COG0784	Response regulator, receiver
EPB58_RS24575	COG2205	protein histidine kinase activity
EPB58_RS24590	COG3278	Belongs to the heme-copper respiratory oxidase family
EPB58_RS24605	COG2010	Cytochrome c
EPB58_RS24615	COG2217	Heavy metal translocating P-type atpase
EPB58_RS24630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB58_RS24635	COG0589	response to stress
EPB58_RS24650	COG2992	FlgJ-related protein
EPB58_RS24660	COG3842	ATPase activity
EPB58_RS24670	COG1177	transmembrane transport
EPB58_RS24680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EPB58_RS24685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPB58_RS24705	COG0437	4 iron, 4 sulfur cluster binding
EPB58_RS24710	COG3383	formate dehydrogenase (NAD+) activity
EPB58_RS24710	COG0243	molybdopterin cofactor binding
EPB58_RS24720	COG3381	protein complex oligomerization
EPB58_RS24740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPB58_RS24745	COG0488	(ABC) transporter
EPB58_RS24765	COG4191	Histidine kinase
EPB58_RS24770	COG2204	response regulator
EPB58_RS24780	COG4662	Binding-protein-dependent transport system inner membrane component
EPB58_RS24785	COG3842	ATPase activity
EPB58_RS24795	COG0303	'Molybdopterin
EPB58_RS24805	COG1940	carbohydrate kinase activity
EPB58_RS24810	COG3148	PFAM DTW domain containing protein
EPB58_RS24850	COG0840	transmembrane signaling receptor activity
EPB58_RS24855	COG0791	NLP P60 protein
EPB58_RS24865	COG3706	GGDEF domain
EPB58_RS24870	COG2201	protein-glutamate methylesterase activity
EPB58_RS24875	COG3001	Fructosamine kinase
EPB58_RS24885	COG0307	riboflavin synthase, alpha
EPB58_RS24890	COG0534	Mate efflux family protein
EPB58_RS24900	COG1793	dna ligase
EPB58_RS24930	COG2204	response regulator
EPB58_RS24980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB58_RS24990	COG3064	Membrane
EPB58_RS25020	COG2199	diguanylate cyclase activity
EPB58_RS25020	COG2203	Gaf domain
EPB58_RS25030	COG0602	queuosine metabolic process
EPB58_RS25035	COG0561	phosphatase activity
EPB58_RS25060	COG2828	Protein conserved in bacteria
EPB58_RS25070	COG0372	Belongs to the citrate synthase family
EPB58_RS25075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EPB58_RS25185	COG3437	response regulator, receiver
EPB58_RS25185	COG0784	Response regulator, receiver
EPB58_RS25195	COG0456	acetyltransferase
EPB58_RS25220	COG0730	response to heat
EPB58_RS25225	COG2358	TRAP transporter, solute receptor (TAXI family
EPB58_RS25230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB58_RS25245	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS25280	COG2197	response regulator
EPB58_RS25285	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPB58_RS25295	COG1846	Transcriptional regulator
EPB58_RS25310	COG1560	Kdo2-lipid A biosynthetic process
EPB58_RS25315	COG0583	DNA-binding transcription factor activity
EPB58_RS25320	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS25325	COG0531	amino acid
EPB58_RS25350	COG3063	Type IV pilus biogenesis stability protein PilW
EPB58_RS25375	COG1643	Atp-dependent helicase
EPB58_RS25380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPB58_RS25395	COG3302	dmso reductase anchor subunit
EPB58_RS25400	COG0437	4 iron, 4 sulfur cluster binding
EPB58_RS25405	COG0243	molybdopterin cofactor binding
EPB58_RS25435	COG3706	GGDEF domain
EPB58_RS25445	COG0443	Heat shock 70 kDa protein
EPB58_RS25450	COG0443	Heat shock 70 kDa protein
EPB58_RS25475	COG0583	DNA-binding transcription factor activity
EPB58_RS25485	COG2165	general secretion pathway protein
EPB58_RS25490	COG1132	(ABC) transporter
EPB58_RS25495	COG1132	(ABC) transporter
EPB58_RS25510	COG4774	siderophore transport
EPB58_RS25515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB58_RS25520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB58_RS25525	COG1120	ATPase activity
EPB58_RS25540	COG0814	amino acid
EPB58_RS25545	COG1454	alcohol dehydrogenase
EPB58_RS25555	COG3706	GGDEF domain
EPB58_RS25560	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS25565	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB58_RS25575	COG0861	Integral membrane protein TerC family
EPB58_RS25585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB58_RS25590	COG1328	CTP reductase activity
EPB58_RS25595	COG1280	lysine exporter protein (LysE YggA)
EPB58_RS25605	COG5001	Diguanylate cyclase
EPB58_RS25605	COG3300	MHYT domain
EPB58_RS25615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB58_RS25615	COG4191	Histidine kinase
EPB58_RS25620	COG0471	metal ion transport
EPB58_RS25660	COG1643	Atp-dependent helicase
EPB58_RS25670	COG2949	membrane
EPB58_RS25675	COG0471	metal ion transport
EPB58_RS25680	COG3706	GGDEF domain
EPB58_RS25700	COG0492	ferredoxin-NADP+ reductase activity
EPB58_RS25705	COG4988	ABC transporter
EPB58_RS25710	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPB58_RS25720	COG2610	gluconate transmembrane transporter activity
EPB58_RS25725	COG0583	DNA-binding transcription factor activity
EPB58_RS25745	COG5001	Diguanylate cyclase
EPB58_RS25745	COG5002	protein histidine kinase activity
EPB58_RS25745	COG3447	MASE1 domain protein
EPB58_RS25755	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EPB58_RS25765	COG4191	Histidine kinase
EPB58_RS25765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB58_RS25780	COG3070	regulator of competence-specific genes
EPB58_RS25795	COG2431	L-lysine efflux transmembrane transporter activity
EPB58_RS25805	COG0076	glutamate decarboxylase activity
EPB58_RS25810	COG1737	Transcriptional regulator
EPB58_RS25820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB58_RS25830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB58_RS25860	COG4181	ATPase activity
EPB58_RS25865	COG0534	Mate efflux family protein
EPB58_RS25870	COG0702	epimerase
EPB58_RS25875	COG1609	Transcriptional regulator
EPB58_RS25885	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB58_RS25895	COG2814	Major facilitator Superfamily
EPB58_RS25900	COG1187	pseudouridine synthase activity
EPB58_RS25905	COG1061	Type III restriction enzyme res subunit
EPB58_RS25960	COG3313	Fe-S protein
EPB58_RS25970	COG0659	secondary active sulfate transmembrane transporter activity
EPB58_RS25995	COG0493	'glutamate synthase
EPB58_RS26005	COG0398	Pfam SNARE associated Golgi protein
EPB58_RS26010	COG4134	Bacterial extracellular solute-binding protein
EPB58_RS26015	COG4135	transport system, permease component
EPB58_RS26020	COG4136	ATPase activity
EPB58_RS26025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPB58_RS26030	COG3604	Transcriptional regulator
EPB58_RS26035	COG1151	hydroxylamine reductase activity
EPB58_RS26040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB58_RS26050	COG0564	pseudouridine synthase activity
EPB58_RS26060	COG0733	neurotransmitter:sodium symporter activity
EPB58_RS26070	COG0626	cystathionine gamma-synthase activity
EPB58_RS26075	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPB58_RS26085	COG2818	Glycosylase
EPB58_RS26115	COG1842	Phage shock protein A
EPB58_RS26120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EPB58_RS26135	COG4171	peptide transport system, permease
EPB58_RS26145	COG4172	Belongs to the ABC transporter superfamily
EPB58_RS26155	COG1227	inorganic diphosphatase activity
EPB58_RS26160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB58_RS26165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB58_RS26170	COG1121	(ABC) transporter
EPB58_RS26185	COG0243	molybdopterin cofactor binding
EPB58_RS26190	COG3005	denitrification pathway
EPB58_RS26195	COG4459	periplasmic nitrate reductase
EPB58_RS26200	COG0390	transport system, permease component
EPB58_RS26205	COG2116	formate transmembrane transporter activity
EPB58_RS26230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB58_RS26235	COG1435	thymidine kinase activity
EPB58_RS26240	COG0215	cysteine-tRNA ligase activity
EPB58_RS26245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB58_RS26250	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB58_RS26255	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB58_RS26260	COG3012	SEC-C Motif Domain Protein
EPB58_RS26265	COG0140	phosphoribosyl-ATP diphosphatase activity
EPB58_RS26265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPB58_RS26275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPB58_RS26280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPB58_RS26285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB58_RS26285	COG0131	Imidazoleglycerol-phosphate dehydratase
EPB58_RS26295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPB58_RS26305	COG1757	Na H antiporter
EPB58_RS26315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS26325	COG0482	sulfurtransferase activity
EPB58_RS26335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPB58_RS26345	COG2268	Band 7 protein
EPB58_RS26355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPB58_RS26370	COG0300	oxidoreductase activity
EPB58_RS26410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPB58_RS26415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPB58_RS26435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPB58_RS26445	COG1674	ftsk spoiiie
EPB58_RS26455	COG0686	Belongs to the AlaDH PNT family
EPB58_RS26490	COG4934	collagen metabolic process
EPB58_RS26500	COG3568	Endonuclease Exonuclease Phosphatase
EPB58_RS26525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB58_RS26530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB58_RS26535	COG0800	Aldolase
EPB58_RS26540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB58_RS26545	COG1917	Cupin 2, conserved barrel domain protein
EPB58_RS26565	COG2186	Transcriptional regulator
EPB58_RS26570	COG1028	Short-chain dehydrogenase reductase Sdr
EPB58_RS26575	COG2186	Transcriptional regulator
EPB58_RS26580	COG0517	IMP dehydrogenase activity
EPB58_RS26585	COG2176	DNA-directed DNA polymerase activity