locus-tag	class	description
CU052_RS00025	COG1132	(ABC) transporter
CU052_RS00050	COG4591	ABC-type transport system involved in lipoprotein release permease component
CU052_RS00055	COG1136	(ABC) transporter
CU052_RS00060	COG4591	ABC-type transport system involved in lipoprotein release permease component
CU052_RS00070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CU052_RS00085	COG1252	NADH dehydrogenase
CU052_RS00115	COG0537	adenosine 5'-monophosphoramidase activity
CU052_RS00135	COG2217	Heavy metal translocating P-type atpase
CU052_RS00145	COG0517	IMP dehydrogenase activity
CU052_RS00145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CU052_RS00145	COG0617	tRNA 3'-terminal CCA addition
CU052_RS00150	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CU052_RS00155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CU052_RS00160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU052_RS00165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU052_RS00190	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CU052_RS00195	COG1946	Acyl-CoA thioesterase
CU052_RS00205	COG1522	sequence-specific DNA binding
CU052_RS00305	COG2433	Pfam Transposase IS66
CU052_RS00335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU052_RS00390	COG2855	membrane
CU052_RS00405	COG0583	DNA-binding transcription factor activity
CU052_RS00410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS00410	COG1263	PTS System
CU052_RS00410	COG2190	(PTS) system
CU052_RS00425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU052_RS00430	COG0596	Alpha beta hydrolase
CU052_RS00440	COG1169	isochorismate synthase
CU052_RS00445	COG0436	Aminotransferase
CU052_RS00450	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CU052_RS00485	COG2433	Pfam Transposase IS66
CU052_RS00505	COG2091	lysine biosynthetic process via aminoadipic acid
CU052_RS00520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU052_RS00540	COG1136	(ABC) transporter
CU052_RS00545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU052_RS00560	COG0154	amidase activity
CU052_RS00605	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU052_RS00615	COG3321	synthase
CU052_RS00615	COG0300	oxidoreductase activity
CU052_RS00615	COG0318	PFAM AMP-dependent synthetase and ligase
CU052_RS00615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU052_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS00650	COG2801	Transposase and inactivated derivatives
CU052_RS00660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU052_RS00665	COG0776	regulation of translation
CU052_RS00670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CU052_RS00705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CU052_RS00710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CU052_RS00715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CU052_RS00730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU052_RS00735	COG0569	domain protein
CU052_RS00740	COG0513	Belongs to the DEAD box helicase family
CU052_RS00745	COG1253	flavin adenine dinucleotide binding
CU052_RS00750	COG4771	TonB-dependent receptor
CU052_RS00765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU052_RS00765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU052_RS00770	COG1535	isochorismatase
CU052_RS00770	COG3433	isochorismatase activity
CU052_RS00775	COG1021	2,3-dihydroxybenzoate-AMP ligase
CU052_RS00780	COG1169	isochorismate synthase
CU052_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS00830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU052_RS00835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU052_RS00855	COG1216	Glycosyl transferase, family 2
CU052_RS00860	COG2986	histidine ammonia-lyase
CU052_RS00895	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS00930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU052_RS00940	COG2951	lytic endotransglycosylase activity
CU052_RS00955	COG2894	cell division
CU052_RS00960	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CU052_RS00965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CU052_RS00970	COG0318	PFAM AMP-dependent synthetase and ligase
CU052_RS00975	COG2267	carboxylic ester hydrolase activity
CU052_RS00980	COG3065	identical protein binding
CU052_RS00990	COG1214	PFAM Peptidase M22, glycoprotease
CU052_RS00995	COG1199	ATP-dependent helicase activity
CU052_RS01000	COG0788	formyltetrahydrofolate deformylase activity
CU052_RS01005	COG3102	Protein conserved in bacteria
CU052_RS01035	COG1918	ferrous iron import across plasma membrane
CU052_RS01040	COG4977	sequence-specific DNA binding
CU052_RS01045	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CU052_RS01050	COG1121	(ABC) transporter
CU052_RS01055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU052_RS01070	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU052_RS01075	COG0567	Dehydrogenase, E1 component
CU052_RS01085	COG1053	succinate dehydrogenase
CU052_RS01090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CU052_RS01105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CU052_RS01120	COG0033	Phosphoglucomutase
CU052_RS01125	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CU052_RS01130	COG0596	Alpha beta hydrolase
CU052_RS01140	COG0716	FMN binding
CU052_RS01150	COG0735	belongs to the Fur family
CU052_RS01155	COG2165	general secretion pathway protein
CU052_RS01165	COG1263	PTS System
CU052_RS01165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS01165	COG2190	(PTS) system
CU052_RS01175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CU052_RS01180	COG1846	Transcriptional regulator
CU052_RS01180	COG1940	carbohydrate kinase activity
CU052_RS01185	COG4651	solute:proton antiporter activity
CU052_RS01185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CU052_RS01190	COG0367	asparagine synthase
CU052_RS01200	COG2801	Transposase and inactivated derivatives
CU052_RS01205	COG3104	oligopeptide transport
CU052_RS01210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CU052_RS01225	COG3710	Transcriptional regulator
CU052_RS01245	COG0622	Phosphoesterase
CU052_RS01275	COG1090	epimerase
CU052_RS01280	COG0300	oxidoreductase activity
CU052_RS01290	COG3118	belongs to the thioredoxin family
CU052_RS01295	COG0330	HflC and HflK could
CU052_RS01340	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CU052_RS01345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU052_RS01355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS01360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU052_RS01365	COG2190	(PTS) system
CU052_RS01370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU052_RS01375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU052_RS01380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU052_RS01395	COG1705	Flagellar rod assembly protein muramidase FlgJ
CU052_RS01395	COG3951	Flagellar rod assembly protein muramidase FlgJ
CU052_RS01400	COG1706	bacterial-type flagellum-dependent cell motility
CU052_RS01405	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CU052_RS01415	COG4787	bacterial-type flagellum-dependent cell motility
CU052_RS01435	COG1558	bacterial-type flagellum-dependent cell motility
CU052_RS01440	COG1815	bacterial-type flagellum-dependent cell motility
CU052_RS01445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CU052_RS01450	COG0784	Response regulator, receiver
CU052_RS01450	COG0835	chemotaxis
CU052_RS01505	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CU052_RS01520	COG2608	mercury ion transmembrane transporter activity
CU052_RS01520	COG2217	Heavy metal translocating P-type atpase
CU052_RS01565	COG2840	Smr protein MutS2
CU052_RS01570	COG1187	pseudouridine synthase activity
CU052_RS01575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CU052_RS01580	COG0737	Belongs to the 5'-nucleotidase family
CU052_RS01585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CU052_RS01590	COG2912	Transglutaminase-like superfamily
CU052_RS01595	COG3094	Invasion gene expression up-regulator, SirB
CU052_RS01600	COG2890	protein-(glutamine-N5) methyltransferase activity
CU052_RS01625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CU052_RS01740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU052_RS01755	COG1702	phosphate starvation-inducible protein PhoH
CU052_RS01765	COG4535	Mg2 and Co2 transporter CorC
CU052_RS01770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CU052_RS01775	COG2888	peptidyl-tyrosine sulfation
CU052_RS01785	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CU052_RS01790	COG1466	dna polymerase III delta subunit
CU052_RS01795	COG0799	negative regulation of ribosome biogenesis
CU052_RS01805	COG0768	penicillin binding
CU052_RS01810	COG0772	Belongs to the SEDS family
CU052_RS01815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CU052_RS01820	COG1686	Belongs to the peptidase S11 family
CU052_RS01840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CU052_RS01845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU052_RS01860	COG0366	Alpha amylase catalytic
CU052_RS01865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS01865	COG1263	PTS System
CU052_RS01875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CU052_RS01880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CU052_RS01885	COG2011	ABC-type metal ion transport system permease component
CU052_RS01890	COG1464	Belongs to the NlpA lipoprotein family
CU052_RS01905	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CU052_RS01930	COG1611	Belongs to the LOG family
CU052_RS01950	COG2363	Small membrane protein
CU052_RS01960	COG0583	DNA-binding transcription factor activity
CU052_RS01975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CU052_RS01985	COG0142	geranyltranstransferase activity
CU052_RS01995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CU052_RS02000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CU052_RS02025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU052_RS02025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU052_RS02030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CU052_RS02035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CU052_RS02050	COG1073	alpha beta
CU052_RS02055	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CU052_RS02060	COG2252	PERMEase
CU052_RS02065	COG2195	Cleaves the N-terminal amino acid of tripeptides
CU052_RS02095	COG0047	phosphoribosylformylglycinamidine synthase activity
CU052_RS02095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CU052_RS02110	COG0590	tRNA wobble adenosine to inosine editing
CU052_RS02115	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CU052_RS02120	COG2801	Transposase and inactivated derivatives
CU052_RS02140	COG4969	Belongs to the N-Me-Phe pilin family
CU052_RS02165	COG1301	dicarboxylic acid transport
CU052_RS02185	COG0497	DNA recombination
CU052_RS02190	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CU052_RS02195	COG2914	Belongs to the UPF0125 (RnfH) family
CU052_RS02200	COG2867	negative regulation of translational initiation
CU052_RS02215	COG0582	viral genome integration into host DNA
CU052_RS02255	COG2003	Belongs to the UPF0758 family
CU052_RS02295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CU052_RS02320	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CU052_RS02350	COG0583	DNA-binding transcription factor activity
CU052_RS02355	COG1289	transmembrane transporter activity
CU052_RS02375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU052_RS02395	COG0719	Fe-S assembly protein
CU052_RS02400	COG0396	ATPase activity
CU052_RS02405	COG0719	Fe-S assembly protein
CU052_RS02410	COG0316	Belongs to the HesB IscA family
CU052_RS02415	COG2873	o-acetylhomoserine
CU052_RS02420	COG0668	transmembrane transport
CU052_RS02425	COG0583	DNA-binding transcription factor activity
CU052_RS02435	COG1115	amino acid carrier protein
CU052_RS02440	COG1584	GPR1 FUN34 yaaH family protein
CU052_RS02450	COG1757	Na H antiporter
CU052_RS02460	COG0517	IMP dehydrogenase activity
CU052_RS02460	COG0516	GMP reductase activity
CU052_RS02475	COG2203	Gaf domain
CU052_RS02475	COG2199	diguanylate cyclase activity
CU052_RS02490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CU052_RS02495	COG2976	Protein conserved in bacteria
CU052_RS02530	COG2975	iron-sulfur cluster assembly
CU052_RS02535	COG0633	Ferredoxin
CU052_RS02550	COG0316	Belongs to the HesB IscA family
CU052_RS02555	COG0822	iron-sulfur transferase activity
CU052_RS02570	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CU052_RS02575	COG0483	inositol monophosphate 1-phosphatase activity
CU052_RS02590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU052_RS02595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU052_RS02600	COG1862	Preprotein translocase
CU052_RS02625	COG0517	IMP dehydrogenase activity
CU052_RS02635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CU052_RS02640	COG0583	DNA-binding transcription factor activity
CU052_RS02645	COG0450	alkyl hydroperoxide reductase
CU052_RS02675	COG0704	Plays a role in the regulation of phosphate uptake
CU052_RS02680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CU052_RS02685	COG0581	inorganic phosphate transmembrane transporter activity
CU052_RS02690	COG0573	inorganic phosphate transmembrane transporter activity
CU052_RS02695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CU052_RS02700	COG0248	Ppx GppA phosphatase
CU052_RS02710	COG5002	protein histidine kinase activity
CU052_RS02715	COG0745	RESPONSE REGULATOR receiver
CU052_RS02725	COG0826	peptidase U32
CU052_RS02730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CU052_RS02740	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CU052_RS02800	COG0542	response to heat
CU052_RS02805	COG1496	oxidoreductase activity
CU052_RS02810	COG0564	pseudouridine synthase activity
CU052_RS02815	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CU052_RS02820	COG0741	lytic transglycosylase activity
CU052_RS02825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CU052_RS02830	COG0077	Prephenate dehydratase
CU052_RS02830	COG1605	Chorismate mutase
CU052_RS02835	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CU052_RS02850	COG0488	(ABC) transporter
CU052_RS02860	COG0739	heme binding
CU052_RS02865	COG0287	Prephenate dehydrogenase
CU052_RS02865	COG1605	Chorismate mutase
CU052_RS02870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CU052_RS02880	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CU052_RS02905	COG1966	Carbon starvation protein
CU052_RS02910	COG3275	phosphorelay sensor kinase activity
CU052_RS02915	COG3279	Response regulator of the LytR AlgR family
CU052_RS02920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CU052_RS02925	COG1047	Peptidyl-prolyl cis-trans
CU052_RS02940	COG0196	riboflavin kinase activity
CU052_RS02945	COG0728	peptidoglycan biosynthetic process
CU052_RS02950	COG0268	Binds directly to 16S ribosomal RNA
CU052_RS02955	COG0640	Transcriptional regulator
CU052_RS02960	COG0583	DNA-binding transcription factor activity
CU052_RS02965	COG1283	sodium-dependent phosphate transmembrane transporter activity
CU052_RS02980	COG0730	response to heat
CU052_RS02985	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CU052_RS03005	COG0667	Aldo Keto reductase
CU052_RS03030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CU052_RS03035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CU052_RS03040	COG4974	Belongs to the 'phage' integrase family
CU052_RS03045	COG0716	FMN binding
CU052_RS03060	COG0513	Belongs to the DEAD box helicase family
CU052_RS03070	COG3022	response to hydroperoxide
CU052_RS03075	COG1115	amino acid carrier protein
CU052_RS03110	COG0431	NADPH-dependent FMN reductase
CU052_RS03115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CU052_RS03120	COG0083	homoserine kinase activity
CU052_RS03135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU052_RS03150	COG0745	RESPONSE REGULATOR receiver
CU052_RS03160	COG2198	Histidine kinase
CU052_RS03160	COG5002	protein histidine kinase activity
CU052_RS03160	COG0784	Response regulator, receiver
CU052_RS03170	COG3706	GGDEF domain
CU052_RS03170	COG2203	Gaf domain
CU052_RS03170	COG4251	negative regulation of phosphorylation
CU052_RS03170	COG5001	Diguanylate cyclase
CU052_RS03180	COG2801	Transposase and inactivated derivatives
CU052_RS03190	COG0069	glutamate synthase activity
CU052_RS03190	COG0067	glutamate synthase
CU052_RS03190	COG0070	glutamate synthase
CU052_RS03200	COG0070	glutamate synthase
CU052_RS03200	COG0067	glutamate synthase
CU052_RS03200	COG0069	glutamate synthase activity
CU052_RS03205	COG0493	'glutamate synthase
CU052_RS03230	COG2860	membrane
CU052_RS03235	COG0583	DNA-binding transcription factor activity
CU052_RS03240	COG0730	response to heat
CU052_RS03260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CU052_RS03265	COG0505	Belongs to the CarA family
CU052_RS03275	COG0494	nUDIX hydrolase
CU052_RS03290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CU052_RS03295	COG0849	cell division
CU052_RS03300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CU052_RS03315	COG0772	Belongs to the SEDS family
CU052_RS03330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CU052_RS03335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CU052_RS03340	COG0768	penicillin binding
CU052_RS03345	COG3116	cell division
CU052_RS03365	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CU052_RS03380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CU052_RS03385	COG2823	Periplasmic or secreted lipoprotein
CU052_RS03390	COG2969	positive regulation of protein catabolic process
CU052_RS03395	COG0625	glutathione transferase activity
CU052_RS03400	COG2857	Cytochrome c1
CU052_RS03405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CU052_RS03410	COG0723	plastoquinol--plastocyanin reductase activity
CU052_RS03430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CU052_RS03440	COG3105	Protein conserved in bacteria
CU052_RS03455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU052_RS03460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU052_RS03470	COG3150	esterase
CU052_RS03480	COG3151	Protein conserved in bacteria
CU052_RS03485	COG0494	nUDIX hydrolase
CU052_RS03490	COG1538	Outer membrane efflux protein
CU052_RS03500	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CU052_RS03510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CU052_RS03515	COG3025	triphosphatase activity
CU052_RS03520	COG1392	Phosphate transport regulator
CU052_RS03525	COG0306	phosphate transporter
CU052_RS03530	COG4991	sh3 domain protein
CU052_RS03540	COG3267	Type II secretory pathway component ExeA
CU052_RS03540	COG3409	Peptidoglycan-binding domain 1 protein
CU052_RS03555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CU052_RS03560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CU052_RS03570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU052_RS03575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CU052_RS03580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CU052_RS03585	COG1610	YqeY-like protein
CU052_RS03590	COG0358	DNA primase activity
CU052_RS03625	COG2213	PTS system mannitol-specific
CU052_RS03625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS03635	COG3722	fumarate hydratase activity
CU052_RS03640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU052_RS03645	COG5002	protein histidine kinase activity
CU052_RS03665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CU052_RS03670	COG1349	DNA-binding transcription factor activity
CU052_RS03680	COG0469	pyruvate kinase activity
CU052_RS03695	COG0440	acetolactate synthase activity
CU052_RS03700	COG0028	Belongs to the TPP enzyme family
CU052_RS03705	COG1022	Amp-dependent synthetase and ligase
CU052_RS03710	COG0583	DNA-binding transcription factor activity
CU052_RS03720	COG0671	phosphoesterase, PA-phosphatase related
CU052_RS03735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU052_RS03740	COG0473	3-isopropylmalate dehydrogenase activity
CU052_RS03760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CU052_RS03765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CU052_RS03770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU052_RS03775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CU052_RS03780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CU052_RS03800	COG3610	response to peptide
CU052_RS03805	COG2966	Psort location CytoplasmicMembrane, score
CU052_RS03810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CU052_RS03820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CU052_RS03825	COG0142	geranyltranstransferase activity
CU052_RS03865	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CU052_RS03870	COG1178	ABC-type Fe3 transport system permease component
CU052_RS03875	COG4143	(ABC) transporter
CU052_RS03880	COG0163	prenyltransferase activity
CU052_RS03885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CU052_RS03895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CU052_RS03905	COG2105	PFAM AIG2 family protein
CU052_RS03915	COG0729	surface antigen
CU052_RS03920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU052_RS03930	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CU052_RS03945	COG1136	(ABC) transporter
CU052_RS03965	COG0529	Catalyzes the synthesis of activated sulfate
CU052_RS03970	COG3273	potassium ion transport
CU052_RS03970	COG0471	metal ion transport
CU052_RS03985	COG1648	precorrin-2 dehydrogenase activity
CU052_RS03985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CU052_RS03990	COG0737	Belongs to the 5'-nucleotidase family
CU052_RS04000	COG0513	Belongs to the DEAD box helicase family
CU052_RS04005	COG2153	protein acetylation
CU052_RS04020	COG0545	Peptidyl-prolyl cis-trans isomerase
CU052_RS04030	COG0203	ribosomal protein L17
CU052_RS04035	COG0202	RNA polymerase activity
CU052_RS04045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CU052_RS04050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CU052_RS04055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CU052_RS04060	COG0201	protein transport
CU052_RS04065	COG0200	Binds to the 23S rRNA
CU052_RS04070	COG1841	ribosomal large subunit assembly
CU052_RS04085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CU052_RS04135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CU052_RS04155	COG0088	Forms part of the polypeptide exit tunnel
CU052_RS04170	COG0254	rRNA binding
CU052_RS04180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CU052_RS04185	COG1609	Transcriptional regulator
CU052_RS04210	COG2003	Belongs to the UPF0758 family
CU052_RS04245	COG1575	Belongs to the MenA family. Type 1 subfamily
CU052_RS04250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU052_RS04260	COG1494	fructose-1,6-bisphosphatase
CU052_RS04290	COG0149	triose-phosphate isomerase activity
CU052_RS04315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CU052_RS04345	COG4584	PFAM Integrase catalytic
CU052_RS04355	COG1561	YicC-like family, N-terminal region
CU052_RS04360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CU052_RS04365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CU052_RS04370	COG1560	Kdo2-lipid A biosynthetic process
CU052_RS04380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CU052_RS04390	COG0840	transmembrane signaling receptor activity
CU052_RS04410	COG2194	sulfuric ester hydrolase activity
CU052_RS04425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CU052_RS04440	COG0463	Glycosyl transferase, family 2
CU052_RS04445	COG0859	PFAM glycosyl transferase family 9
CU052_RS04450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CU052_RS04455	COG3642	lipopolysaccharide core region biosynthetic process
CU052_RS04495	COG1519	Transferase
CU052_RS04500	COG0859	PFAM glycosyl transferase family 9
CU052_RS04505	COG1560	Kdo2-lipid A biosynthetic process
CU052_RS04515	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CU052_RS04555	COG2089	acid synthase
CU052_RS04580	COG3306	glycosyltransferase involved in LPS biosynthesis
CU052_RS04625	COG0328	RNA-DNA hybrid ribonuclease activity
CU052_RS04655	COG0745	RESPONSE REGULATOR receiver
CU052_RS04680	COG4608	Belongs to the ABC transporter superfamily
CU052_RS04685	COG0444	Belongs to the ABC transporter superfamily
CU052_RS04690	COG0747	negative chemotaxis
CU052_RS04695	COG4239	(ABC) transporter, permease
CU052_RS04700	COG0601	transmembrane transport
CU052_RS04725	COG0811	peptide transport
CU052_RS04730	COG0848	biopolymer transport protein
CU052_RS04745	COG0194	GDP metabolic process
CU052_RS04750	COG1758	RNA polymerase activity
CU052_RS04755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CU052_RS04760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU052_RS04765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CU052_RS04775	COG2233	PERMEase
CU052_RS04790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CU052_RS04800	COG2183	response to ionizing radiation
CU052_RS04815	COG1040	competence protein
CU052_RS04825	COG0494	nUDIX hydrolase
CU052_RS04830	COG1218	3'(2'),5'-bisphosphate nucleotidase
CU052_RS04840	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CU052_RS04845	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CU052_RS04850	COG3156	type II secretion system protein K
CU052_RS04855	COG4795	General secretion pathway protein
CU052_RS04860	COG2165	general secretion pathway protein
CU052_RS04865	COG2165	general secretion pathway protein
CU052_RS04870	COG2165	general secretion pathway protein
CU052_RS04875	COG1459	type II secretion system
CU052_RS04880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CU052_RS04890	COG3031	protein transport across the cell outer membrane
CU052_RS04895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CU052_RS04915	COG0456	acetyltransferase
CU052_RS04920	COG1490	D-aminoacyl-tRNA deacylase activity
CU052_RS04940	COG1217	gtp-binding protein TYPA
CU052_RS04950	COG0174	glutamine synthetase
CU052_RS04960	COG3852	Histidine kinase
CU052_RS04965	COG2204	response regulator
CU052_RS04975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CU052_RS05005	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CU052_RS05015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU052_RS05015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU052_RS05035	COG0084	hydrolase, TatD family'
CU052_RS05040	COG0805	protein transport
CU052_RS05045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU052_RS05060	COG3165	ubiquinone biosynthetic process from chorismate
CU052_RS05070	COG1322	Protein conserved in bacteria
CU052_RS05090	COG2081	HI0933 family
CU052_RS05100	COG1528	Iron-storage protein
CU052_RS05110	COG0589	response to stress
CU052_RS05125	COG2801	Transposase and inactivated derivatives
CU052_RS05135	COG5002	protein histidine kinase activity
CU052_RS05135	COG5001	Diguanylate cyclase
CU052_RS05140	COG1522	sequence-specific DNA binding
CU052_RS05155	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CU052_RS05165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU052_RS05180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU052_RS05200	COG0800	Aldolase
CU052_RS05205	COG2610	gluconate transmembrane transporter activity
CU052_RS05210	COG3265	gluconokinase activity
CU052_RS05215	COG0129	dihydroxy-acid dehydratase activity
CU052_RS05230	COG2076	Multidrug Resistance protein
CU052_RS05235	COG0583	DNA-binding transcription factor activity
CU052_RS05240	COG1609	Transcriptional regulator
CU052_RS05275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU052_RS05280	COG0601	transmembrane transport
CU052_RS05285	COG0747	negative chemotaxis
CU052_RS05290	COG4172	Belongs to the ABC transporter superfamily
CU052_RS05300	COG0546	phosphoglycolate phosphatase activity
CU052_RS05340	COG1309	transcriptional regulator
CU052_RS05345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU052_RS05350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU052_RS05360	COG2960	long-chain fatty acid transporting porin activity
CU052_RS05365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CU052_RS05370	COG0583	DNA-binding transcription factor activity
CU052_RS05425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU052_RS05430	COG1739	Uncharacterized protein family UPF0029
CU052_RS05440	COG0183	Belongs to the thiolase family
CU052_RS05445	COG0604	alcohol dehydrogenase
CU052_RS05460	COG0425	Belongs to the sulfur carrier protein TusA family
CU052_RS05470	COG2119	membrane
CU052_RS05485	COG0366	Alpha amylase catalytic
CU052_RS05490	COG3977	Valine--pyruvate aminotransferase
CU052_RS05495	COG0071	Belongs to the small heat shock protein (HSP20) family
CU052_RS05500	COG0187	DNA topoisomerase II activity
CU052_RS05510	COG0592	DNA-directed DNA polymerase activity
CU052_RS05535	COG1126	abc transporter atp-binding protein
CU052_RS05565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CU052_RS05570	COG0445	tRNA wobble uridine modification
CU052_RS05580	COG1192	Involved in chromosome partitioning
CU052_RS05585	COG1475	DNA binding
CU052_RS05590	COG3312	ion transport
CU052_RS05595	COG0356	it plays a direct role in the translocation of protons across the membrane
CU052_RS05620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CU052_RS05630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CU052_RS05640	COG0765	amino acid transport
CU052_RS05650	COG2814	Major facilitator Superfamily
CU052_RS05655	COG0583	DNA-binding transcription factor activity
CU052_RS05665	COG0129	dihydroxy-acid dehydratase activity
CU052_RS05670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU052_RS05675	COG3978	acetolactate synthase activity
CU052_RS05720	COG4974	Belongs to the 'phage' integrase family
CU052_RS05820	COG2801	Transposase and inactivated derivatives
CU052_RS05830	COG3706	GGDEF domain
CU052_RS05840	COG0204	Acyl-transferase
CU052_RS05845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CU052_RS05850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CU052_RS05860	COG3084	Protein conserved in bacteria
CU052_RS05870	COG4326	sporulation control protein
CU052_RS05875	COG1272	protein, Hemolysin III
CU052_RS05885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU052_RS05890	COG0569	domain protein
CU052_RS05895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CU052_RS05895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CU052_RS05905	COG0242	peptide deformylase activity
CU052_RS05915	COG0758	DNA mediated transformation
CU052_RS05925	COG0551	DNA topoisomerase type I activity
CU052_RS05930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CU052_RS05935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CU052_RS05950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CU052_RS05960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CU052_RS06010	COG2132	Multicopper oxidase
CU052_RS06030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU052_RS06035	COG2104	thiamine diphosphate biosynthetic process
CU052_RS06050	COG0006	proline dipeptidase activity
CU052_RS06050	COG0006	proline dipeptidase activity
CU052_RS06060	COG2814	Major facilitator Superfamily
CU052_RS06080	COG3220	belongs to the UPF0276 family
CU052_RS06090	COG0210	DNA helicase
CU052_RS06100	COG0405	Gamma-glutamyltransferase
CU052_RS06105	COG1280	lysine exporter protein (LysE YggA)
CU052_RS06115	COG2962	Rard protein
CU052_RS06120	COG0514	ATP-dependent DNA helicase (RecQ)
CU052_RS06135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CU052_RS06150	COG3118	belongs to the thioredoxin family
CU052_RS06165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CU052_RS06170	COG0633	Ferredoxin
CU052_RS06210	COG3071	HemY protein
CU052_RS06215	COG2959	enzyme of heme biosynthesis
CU052_RS06220	COG1587	Uroporphyrinogen-III synthase
CU052_RS06230	COG3072	Adenylate cyclase
CU052_RS06245	COG0019	diaminopimelate decarboxylase activity
CU052_RS06265	COG1011	Hydrolase
CU052_RS06275	COG3148	PFAM DTW domain containing protein
CU052_RS06290	COG0561	phosphatase activity
CU052_RS06295	COG2267	carboxylic ester hydrolase activity
CU052_RS06300	COG1280	lysine exporter protein (LysE YggA)
CU052_RS06305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CU052_RS06310	COG0640	Transcriptional regulator
CU052_RS06315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CU052_RS06365	COG2095	MarC family integral membrane protein
CU052_RS06375	COG0742	ribosomal rna small subunit methyltransferase
CU052_RS06380	COG0552	protein localization to endoplasmic reticulum
CU052_RS06380	COG0552	protein localization to endoplasmic reticulum
CU052_RS06385	COG2884	Cell division ATP-binding protein ftsE
CU052_RS06390	COG2177	Part of the ABC transporter FtsEX involved in
CU052_RS06405	COG0705	Rhomboid family
CU052_RS06410	COG1580	Controls the rotational direction of flagella during chemotaxis
CU052_RS06415	COG3161	chorismate lyase activity
CU052_RS06425	COG2937	Belongs to the GPAT DAPAT family
CU052_RS06445	COG0534	Mate efflux family protein
CU052_RS06450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU052_RS06570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU052_RS06580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CU052_RS06630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CU052_RS06635	COG0250	Participates in transcription elongation, termination and antitermination
CU052_RS06650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CU052_RS06670	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CU052_RS06675	COG2816	NAD+ diphosphatase activity
CU052_RS06695	COG1573	uracil-dna glycosylase
CU052_RS06705	COG3068	Protein conserved in bacteria
CU052_RS06710	COG1253	flavin adenine dinucleotide binding
CU052_RS06725	COG0151	Belongs to the GarS family
CU052_RS06740	COG0789	Transcriptional regulator
CU052_RS06745	COG3710	Transcriptional regulator
CU052_RS06755	COG0531	amino acid
CU052_RS06760	COG1982	Orn Lys Arg decarboxylase major
CU052_RS06795	COG2199	diguanylate cyclase activity
CU052_RS06800	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CU052_RS06805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU052_RS06820	COG0439	Biotin carboxylase
CU052_RS06825	COG0511	ligase activity, forming carbon-carbon bonds
CU052_RS06830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CU052_RS06835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU052_RS06850	COG2814	Major facilitator Superfamily
CU052_RS06855	COG0784	Response regulator, receiver
CU052_RS06855	COG2198	Histidine kinase
CU052_RS06855	COG2205	protein histidine kinase activity
CU052_RS06885	COG2095	MarC family integral membrane protein
CU052_RS06895	COG4232	protein-disulfide reductase activity
CU052_RS06900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CU052_RS06905	COG1027	Aspartate ammonia-lyase
CU052_RS06915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CU052_RS06920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU052_RS06925	COG2205	protein histidine kinase activity
CU052_RS06930	COG0745	RESPONSE REGULATOR receiver
CU052_RS06935	COG3678	ATP-independent chaperone mediated protein folding
CU052_RS06940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CU052_RS06950	COG0534	Mate efflux family protein
CU052_RS06975	COG1509	lysine 2,3-aminomutase activity
CU052_RS07005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CU052_RS07010	COG1053	succinate dehydrogenase
CU052_RS07035	COG4942	peptidase
CU052_RS07040	COG1045	serine acetyltransferase
CU052_RS07050	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CU052_RS07055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU052_RS07060	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CU052_RS07070	COG0840	transmembrane signaling receptor activity
CU052_RS07075	COG0471	metal ion transport
CU052_RS07085	COG1162	GTPase activity
CU052_RS07155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CU052_RS07160	COG0802	atpase or kinase
CU052_RS07170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CU052_RS07185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CU052_RS07190	COG0330	HflC and HflK could
CU052_RS07195	COG0330	HflC and HflK could
CU052_RS07200	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CU052_RS07205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CU052_RS07215	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CU052_RS07220	COG1017	nitric oxide dioxygenase activity
CU052_RS07220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU052_RS07235	COG0557	exoribonuclease II activity
CU052_RS07240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU052_RS07245	COG0546	phosphoglycolate phosphatase activity
CU052_RS07270	COG0512	Glutamine amidotransferase of anthranilate synthase
CU052_RS07275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU052_RS07295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU052_RS07300	COG3954	Phosphoribulokinase
CU052_RS07310	COG0429	hydrolase of the alpha beta-hydrolase fold
CU052_RS07320	COG0488	(ABC) transporter
CU052_RS07330	COG2249	NAD(P)H dehydrogenase (quinone) activity
CU052_RS07345	COG1047	Peptidyl-prolyl cis-trans
CU052_RS07355	COG1446	asparaginase
CU052_RS07370	COG0545	Peptidyl-prolyl cis-trans isomerase
CU052_RS07375	COG2964	Protein conserved in bacteria
CU052_RS07380	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CU052_RS07385	COG2923	Belongs to the DsrF TusC family
CU052_RS07390	COG2168	tRNA wobble position uridine thiolation
CU052_RS07405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CU052_RS07415	COG2906	2 iron, 2 sulfur cluster binding
CU052_RS07425	COG0281	malic enzyme
CU052_RS07435	COG0626	cystathionine gamma-synthase activity
CU052_RS07440	COG0460	homoserine dehydrogenase
CU052_RS07440	COG0527	aspartate kinase activity
CU052_RS07445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CU052_RS07455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CU052_RS07465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CU052_RS07480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CU052_RS07480	COG0165	Argininosuccinate lyase
CU052_RS07495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU052_RS07500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CU052_RS07500	COG0678	peroxiredoxin activity
CU052_RS07510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CU052_RS07555	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CU052_RS07560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CU052_RS07565	COG0360	Binds together with S18 to 16S ribosomal RNA
CU052_RS07585	COG0305	Participates in initiation and elongation during chromosome replication
CU052_RS07590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CU052_RS07600	COG0432	Pfam Uncharacterised protein family UPF0047
CU052_RS07615	COG0735	belongs to the Fur family
CU052_RS07620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU052_RS07640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CU052_RS07690	COG0646	methionine synthase
CU052_RS07690	COG1410	methionine synthase
CU052_RS07695	COG0527	aspartate kinase activity
CU052_RS07705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CU052_RS07715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU052_RS07730	COG0629	single-stranded DNA binding
CU052_RS07735	COG2199	diguanylate cyclase activity
CU052_RS07735	COG2200	EAL domain
CU052_RS07775	COG3409	Peptidoglycan-binding domain 1 protein
CU052_RS07775	COG3267	Type II secretory pathway component ExeA
CU052_RS07785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CU052_RS07790	COG1459	type II secretion system
CU052_RS07800	COG2165	general secretion pathway protein
CU052_RS07835	COG1077	Cell shape determining protein MreB Mrl
CU052_RS07840	COG1792	Involved in formation and maintenance of cell shape
CU052_RS07845	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CU052_RS07850	COG0424	maF-like protein
CU052_RS07860	COG3164	Protein of unknown function
CU052_RS07865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU052_RS07870	COG0312	modulator of DNA gyrase
CU052_RS07875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CU052_RS07890	COG0564	pseudouridine synthase activity
CU052_RS07895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CU052_RS07905	COG0312	modulator of DNA gyrase
CU052_RS07910	COG2239	Acts as a magnesium transporter
CU052_RS07915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS07925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS07930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CU052_RS07940	COG1137	ATPase activity
CU052_RS07945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CU052_RS07965	COG1127	ABC transporter
CU052_RS07970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU052_RS07975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU052_RS07980	COG2854	intermembrane phospholipid transfer
CU052_RS07990	COG5007	Belongs to the BolA IbaG family
CU052_RS08000	COG0204	Acyl-transferase
CU052_RS08005	COG0251	oxidation-reduction process
CU052_RS08045	COG0456	acetyltransferase
CU052_RS08055	COG0525	valine-tRNA ligase activity
CU052_RS08060	COG2927	DNA polymerase III (CHI subunit)
CU052_RS08070	COG0795	lipopolysaccharide-transporting ATPase activity
CU052_RS08075	COG0795	lipopolysaccharide-transporting ATPase activity
CU052_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS08105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CU052_RS08115	COG1447	Phosphotransferase system cellobiose-specific component IIA
CU052_RS08120	COG1486	melibiose metabolic process
CU052_RS08135	COG3437	response regulator, receiver
CU052_RS08190	COG1012	belongs to the aldehyde dehydrogenase family
CU052_RS08290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CU052_RS08295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CU052_RS08310	COG0762	integral membrane protein
CU052_RS08315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU052_RS08320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CU052_RS08335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CU052_RS08340	COG1678	Uncharacterized ACR, COG1678
CU052_RS08345	COG0189	ligase activity
CU052_RS08350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CU052_RS08355	COG2356	endonuclease I
CU052_RS08380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CU052_RS08400	COG0191	fructose-bisphosphate aldolase activity
CU052_RS08405	COG0668	transmembrane transport
CU052_RS08420	COG0583	DNA-binding transcription factor activity
CU052_RS08430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CU052_RS08440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CU052_RS08450	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CU052_RS08465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU052_RS08470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU052_RS08490	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CU052_RS08500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CU052_RS08510	COG1595	DNA-templated transcription, initiation
CU052_RS08525	COG3086	response to oxidative stress
CU052_RS08545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CU052_RS08550	COG1381	Involved in DNA repair and RecF pathway recombination
CU052_RS08555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CU052_RS08580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CU052_RS08585	COG3956	TIGRFAM MazG family protein
CU052_RS08595	COG0148	phosphopyruvate hydratase activity
CU052_RS08605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CU052_RS08635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CU052_RS08650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CU052_RS08665	COG0527	aspartate kinase activity
CU052_RS08725	COG3630	sodium ion export across plasma membrane
CU052_RS08730	COG5016	pyruvate
CU052_RS08730	COG0511	ligase activity, forming carbon-carbon bonds
CU052_RS08735	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CU052_RS08750	COG0612	Peptidase, M16
CU052_RS08770	COG4536	flavin adenine dinucleotide binding
CU052_RS08775	COG4137	Cytochrome C assembly protein
CU052_RS08780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CU052_RS08805	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CU052_RS08810	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CU052_RS08815	COG0237	dephospho-CoA kinase activity
CU052_RS08825	COG1459	type II secretion system
CU052_RS08830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CU052_RS08855	COG2186	Transcriptional regulator
CU052_RS08860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CU052_RS08865	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU052_RS08870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU052_RS08885	COG0288	reversible hydration of carbon dioxide
CU052_RS08890	COG0659	secondary active sulfate transmembrane transporter activity
CU052_RS08895	COG1131	(ABC) transporter
CU052_RS08900	COG0842	Transport permease protein
CU052_RS08905	COG1560	Kdo2-lipid A biosynthetic process
CU052_RS08920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CU052_RS08935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CU052_RS08950	COG1643	Atp-dependent helicase
CU052_RS08955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU052_RS08960	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU052_RS08965	COG1049	propionate catabolic process, 2-methylcitrate cycle
CU052_RS08985	COG0004	ammonium transporteR
CU052_RS08990	COG1840	ABC-type Fe3 transport system, periplasmic component
CU052_RS09000	COG3842	ATPase activity
CU052_RS09005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU052_RS09020	COG2971	BadF BadG BcrA BcrD
CU052_RS09030	COG4608	Belongs to the ABC transporter superfamily
CU052_RS09035	COG0444	Belongs to the ABC transporter superfamily
CU052_RS09040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU052_RS09050	COG0747	negative chemotaxis
CU052_RS09055	COG0784	Response regulator, receiver
CU052_RS09055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU052_RS09055	COG2198	Histidine kinase
CU052_RS09055	COG2205	protein histidine kinase activity
CU052_RS09070	COG0628	permease
CU052_RS09080	COG0316	Belongs to the HesB IscA family
CU052_RS09095	COG0739	heme binding
CU052_RS09100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CU052_RS09110	COG2027	D-alanyl-D-alanine carboxypeptidase
CU052_RS09115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CU052_RS09120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CU052_RS09125	COG1534	Rna-binding protein
CU052_RS09135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU052_RS09140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CU052_RS09150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CU052_RS09170	COG0195	Participates in both transcription termination and antitermination
CU052_RS09190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CU052_RS09210	COG0534	Mate efflux family protein
CU052_RS09215	COG0826	peptidase U32
CU052_RS09220	COG0826	peptidase U32
CU052_RS09230	COG3154	lipid carrier protein
CU052_RS09235	COG3153	acetyltransferase
CU052_RS09255	COG3706	GGDEF domain
CU052_RS09260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CU052_RS09270	COG0084	hydrolase, TatD family'
CU052_RS09275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU052_RS09285	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CU052_RS09295	COG0813	purine-nucleoside phosphorylase activity
CU052_RS09305	COG0560	Phosphoserine phosphatase
CU052_RS09315	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CU052_RS09320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CU052_RS09325	COG0583	DNA-binding transcription factor activity
CU052_RS09335	COG1022	Amp-dependent synthetase and ligase
CU052_RS09340	COG2169	Transcriptional regulator
CU052_RS09365	COG4964	Belongs to the GSP D family
CU052_RS09425	COG0583	DNA-binding transcription factor activity
CU052_RS09430	COG0531	amino acid
CU052_RS09435	COG2731	YhcH YjgK YiaL family protein
CU052_RS09440	COG3250	beta-galactosidase activity
CU052_RS09450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU052_RS09460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS09460	COG1263	PTS System
CU052_RS09470	COG2017	converts alpha-aldose to the beta-anomer
CU052_RS09485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU052_RS09490	COG0768	penicillin binding
CU052_RS09500	COG1609	Transcriptional regulator
CU052_RS09520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CU052_RS09525	COG1349	DNA-binding transcription factor activity
CU052_RS09535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CU052_RS09545	COG2271	Major facilitator Superfamily
CU052_RS09550	COG0584	glycerophosphoryl diester phosphodiesterase
CU052_RS09555	COG2171	N-acyltransferase activity
CU052_RS09570	COG3141	response to X-ray
CU052_RS09590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CU052_RS09595	COG1074	ATP-dependent DNA helicase activity
CU052_RS09600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CU052_RS09625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CU052_RS09625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CU052_RS09640	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CU052_RS09645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CU052_RS09650	COG2166	iron-sulfur cluster assembly
CU052_RS09655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU052_RS09660	COG0693	protein deglycase activity
CU052_RS09665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CU052_RS09670	COG3248	Nucleoside-binding outer membrane protein
CU052_RS09690	COG1595	DNA-templated transcription, initiation
CU052_RS09720	COG0271	Belongs to the BolA IbaG family
CU052_RS09745	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CU052_RS09755	COG1477	protein flavinylation
CU052_RS09770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CU052_RS09775	COG0514	ATP-dependent DNA helicase (RecQ)
CU052_RS09780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CU052_RS09795	COG0733	neurotransmitter:sodium symporter activity
CU052_RS09820	COG1720	tRNA m6t6A37 methyltransferase activity
CU052_RS09835	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CU052_RS09860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU052_RS09880	COG2801	Transposase and inactivated derivatives
CU052_RS09905	COG3098	single-species biofilm formation
CU052_RS09910	COG0564	pseudouridine synthase activity
CU052_RS09925	COG0024	Methionine aminopeptidase
CU052_RS09950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CU052_RS09955	COG0575	Belongs to the CDS family
CU052_RS09965	COG0750	zinc metalloprotease
CU052_RS09975	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CU052_RS09980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CU052_RS10005	COG0587	DNA-directed DNA polymerase activity
CU052_RS10025	COG0347	Belongs to the P(II) protein family
CU052_RS10040	COG1388	LysM domain
CU052_RS10040	COG0741	lytic transglycosylase activity
CU052_RS10050	COG2226	methyltransferase
CU052_RS10060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CU052_RS10085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CU052_RS10090	COG0121	glutamine amidotransferase
CU052_RS10095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CU052_RS10105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CU052_RS10110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CU052_RS10115	COG2233	PERMEase
CU052_RS10135	COG1393	Belongs to the ArsC family
CU052_RS10140	COG4783	chaperone-mediated protein folding
CU052_RS10155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CU052_RS10160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CU052_RS10170	COG0732	type I restriction modification DNA specificity domain
CU052_RS10175	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CU052_RS10235	COG4615	Cyclic peptide transporter
CU052_RS10240	COG4166	transmembrane transport
CU052_RS10245	COG4174	ABC transporter (Permease)
CU052_RS10250	COG4239	(ABC) transporter, permease
CU052_RS10255	COG4172	Belongs to the ABC transporter superfamily
CU052_RS10275	COG4774	siderophore transport
CU052_RS10280	COG3251	PFAM MbtH domain protein
CU052_RS10330	COG0612	Peptidase, M16
CU052_RS10335	COG4178	(ABC) transporter
CU052_RS10340	COG4771	TonB-dependent receptor
CU052_RS10350	COG0811	peptide transport
CU052_RS10355	COG0811	peptide transport
CU052_RS10360	COG0848	biopolymer transport protein
CU052_RS10405	COG2801	Transposase and inactivated derivatives
CU052_RS10420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CU052_RS10460	COG2716	regulation of RNA biosynthetic process
CU052_RS10465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU052_RS10470	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CU052_RS10490	COG1393	Belongs to the ArsC family
CU052_RS10515	COG2837	iron assimilation
CU052_RS10520	COG2169	Transcriptional regulator
CU052_RS10525	COG1486	melibiose metabolic process
CU052_RS10530	COG2211	Major facilitator Superfamily
CU052_RS10535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU052_RS10545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU052_RS10555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU052_RS10560	COG1334	flagellar protein FlaG
CU052_RS10565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CU052_RS10575	COG1516	flagellar protein fliS
CU052_RS10595	COG1677	Flagellar hook-basal body complex protein FliE
CU052_RS10605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU052_RS10660	COG1987	bacterial-type flagellum assembly
CU052_RS10665	COG1684	flagellar biosynthetic protein fliR
CU052_RS10700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CU052_RS10705	COG2198	Histidine kinase
CU052_RS10705	COG0784	Response regulator, receiver
CU052_RS10705	COG0643	Histidine kinase
CU052_RS10710	COG2201	protein-glutamate methylesterase activity
CU052_RS10715	COG1192	Involved in chromosome partitioning
CU052_RS10725	COG0835	chemotaxis
CU052_RS10735	COG4133	protoheme IX ABC transporter activity
CU052_RS10740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU052_RS10745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU052_RS10760	COG1138	Cytochrome C-type biogenesis protein
CU052_RS10765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU052_RS10775	COG3088	subunit of a heme lyase
CU052_RS10775	COG4235	cytochrome complex assembly
CU052_RS10780	COG2853	Lipoprotein
CU052_RS10805	COG0183	Belongs to the thiolase family
CU052_RS10820	COG2062	phosphohistidine phosphatase, SixA
CU052_RS10830	COG2890	protein-(glutamine-N5) methyltransferase activity
CU052_RS10840	COG2860	membrane
CU052_RS10845	COG3101	peptidyl-lysine hydroxylation
CU052_RS10865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CU052_RS10875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CU052_RS10880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CU052_RS10905	COG0285	dihydrofolate synthase activity
CU052_RS10910	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CU052_RS10915	COG1286	toxin biosynthetic process
CU052_RS10920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CU052_RS10925	COG0583	DNA-binding transcription factor activity
CU052_RS10930	COG0745	RESPONSE REGULATOR receiver
CU052_RS10940	COG2832	Protein of unknown function (DUF454)
CU052_RS10950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CU052_RS10960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CU052_RS10965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CU052_RS10970	COG0814	amino acid
CU052_RS10975	COG0251	oxidation-reduction process
CU052_RS10985	COG2964	Protein conserved in bacteria
CU052_RS11055	COG2801	Transposase and inactivated derivatives
CU052_RS11080	COG4104	PAAR repeat-containing protein
CU052_RS11090	COG1074	ATP-dependent DNA helicase activity
CU052_RS11100	COG2261	transglycosylase associated protein
CU052_RS11105	COG0668	transmembrane transport
CU052_RS11110	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CU052_RS11115	COG0346	lactoylglutathione lyase activity
CU052_RS11125	COG1785	Belongs to the alkaline phosphatase family
CU052_RS11145	COG2226	methyltransferase
CU052_RS11165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CU052_RS11170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU052_RS11180	COG3139	Protein of unknown function (DUF1315)
CU052_RS11185	COG0252	asparaginase activity
CU052_RS11190	COG0616	signal peptide processing
CU052_RS11195	COG1902	pentaerythritol trinitrate reductase activity
CU052_RS11195	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU052_RS11200	COG0778	Nitroreductase
CU052_RS11205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU052_RS11220	COG0123	including yeast histone deacetylase and acetoin utilization protein
CU052_RS11230	COG3083	sulfuric ester hydrolase activity
CU052_RS11255	COG1757	Na H antiporter
CU052_RS11260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CU052_RS11265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU052_RS11270	COG2095	MarC family integral membrane protein
CU052_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
CU052_RS11275	COG1454	alcohol dehydrogenase
CU052_RS11295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CU052_RS11305	COG2056	Na+-H+ antiporter family
CU052_RS11315	COG2885	chlorophyll binding
CU052_RS11325	COG0346	lactoylglutathione lyase activity
CU052_RS11330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CU052_RS11335	COG4660	Part of a membrane complex involved in electron transport
CU052_RS11340	COG4659	FMN binding
CU052_RS11345	COG4658	electron transport chain
CU052_RS11350	COG4656	Part of a membrane complex involved in electron transport
CU052_RS11360	COG4657	Part of a membrane complex involved in electron transport
CU052_RS11365	COG1882	Formate acetyltransferase
CU052_RS11375	COG0556	nucleotide-excision repair
CU052_RS11390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CU052_RS11395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CU052_RS11400	COG0521	Mo-molybdopterin cofactor biosynthetic process
CU052_RS11410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CU052_RS11415	COG0314	molybdopterin synthase activity
CU052_RS11435	COG0601	transmembrane transport
CU052_RS11440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU052_RS11445	COG0444	Belongs to the ABC transporter superfamily
CU052_RS11455	COG0435	Glutathione S-transferase
CU052_RS11460	COG3174	membrane
CU052_RS11465	COG0857	belongs to the CobB CobQ family
CU052_RS11465	COG0280	phosphate acetyltransferase
CU052_RS11490	COG4120	Belongs to the binding-protein-dependent transport system permease family
CU052_RS11495	COG1122	ATPase activity
CU052_RS11515	COG3706	GGDEF domain
CU052_RS11520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU052_RS11525	COG0653	protein targeting
CU052_RS11530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CU052_RS11540	COG2186	Transcriptional regulator
CU052_RS11570	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CU052_RS11575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CU052_RS11580	COG0659	secondary active sulfate transmembrane transporter activity
CU052_RS11590	COG1530	ribonuclease E activity
CU052_RS11595	COG0564	pseudouridine synthase activity
CU052_RS11600	COG0424	maF-like protein
CU052_RS11605	COG1399	metal-binding, possibly nucleic acid-binding protein
CU052_RS11620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU052_RS11650	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CU052_RS11665	COG0084	hydrolase, TatD family'
CU052_RS11670	COG1263	PTS System
CU052_RS11670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS11680	COG0733	neurotransmitter:sodium symporter activity
CU052_RS11695	COG4667	esterase of the alpha-beta hydrolase superfamily
CU052_RS11705	COG1940	carbohydrate kinase activity
CU052_RS11710	COG0835	chemotaxis
CU052_RS11710	COG0784	Response regulator, receiver
CU052_RS11740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU052_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS11755	COG0616	signal peptide processing
CU052_RS11765	COG0539	negative regulation of cytoplasmic translation
CU052_RS11775	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CU052_RS11780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CU052_RS11790	COG4166	transmembrane transport
CU052_RS11845	COG3009	Protein conserved in bacteria
CU052_RS11850	COG3008	intermembrane lipid transfer
CU052_RS11850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU052_RS11855	COG2995	paraquat-inducible protein a
CU052_RS11870	COG4232	protein-disulfide reductase activity
CU052_RS11875	COG3118	belongs to the thioredoxin family
CU052_RS11905	COG3153	acetyltransferase
CU052_RS11930	COG0577	efflux transmembrane transporter activity
CU052_RS11940	COG0577	efflux transmembrane transporter activity
CU052_RS11940	COG1136	(ABC) transporter
CU052_RS11985	COG1846	Transcriptional regulator
CU052_RS12020	COG3850	Histidine kinase
CU052_RS12020	COG5002	protein histidine kinase activity
CU052_RS12025	COG0745	RESPONSE REGULATOR receiver
CU052_RS12030	COG0463	Glycosyl transferase, family 2
CU052_RS12035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU052_RS12050	COG2801	Transposase and inactivated derivatives
CU052_RS12060	COG2964	Protein conserved in bacteria
CU052_RS12075	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU052_RS12115	COG1032	radical SAM domain protein
CU052_RS12120	COG1716	ATPase activity
CU052_RS12120	COG5001	Diguanylate cyclase
CU052_RS12135	COG0583	DNA-binding transcription factor activity
CU052_RS12150	COG2350	Protein conserved in bacteria
CU052_RS12155	COG1607	acyl-coa hydrolase
CU052_RS12180	COG1301	dicarboxylic acid transport
CU052_RS12185	COG0159	tryptophan synthase activity
CU052_RS12195	COG0135	phosphoribosylanthranilate isomerase activity
CU052_RS12195	COG0134	indole-3-glycerol-phosphate synthase activity
CU052_RS12205	COG0512	Glutamine amidotransferase of anthranilate synthase
CU052_RS12210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CU052_RS12220	COG0613	PHP domain protein
CU052_RS12225	COG0009	L-threonylcarbamoyladenylate synthase
CU052_RS12235	COG1187	pseudouridine synthase activity
CU052_RS12255	COG0417	DNA replication proofreading
CU052_RS12260	COG2197	response regulator
CU052_RS12265	COG0322	excinuclease ABC activity
CU052_RS12310	COG0019	diaminopimelate decarboxylase activity
CU052_RS12335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU052_RS12340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU052_RS12350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU052_RS12370	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CU052_RS12380	COG0437	4 iron, 4 sulfur cluster binding
CU052_RS12385	COG3301	Polysulphide reductase, NrfD
CU052_RS12390	COG1138	Cytochrome C-type biogenesis protein
CU052_RS12400	COG4235	cytochrome complex assembly
CU052_RS12400	COG3088	subunit of a heme lyase
CU052_RS12410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU052_RS12435	COG2989	Protein conserved in bacteria
CU052_RS12440	COG3108	Peptidase M15
CU052_RS12445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU052_RS12460	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CU052_RS12485	COG1846	Transcriptional regulator
CU052_RS12490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU052_RS12495	COG0840	transmembrane signaling receptor activity
CU052_RS12515	COG1448	Aminotransferase
CU052_RS12520	COG3437	response regulator, receiver
CU052_RS12520	COG2770	Histidine kinase
CU052_RS12555	COG0017	Asparaginyl-tRNA synthetase
CU052_RS12560	COG0840	transmembrane signaling receptor activity
CU052_RS12565	COG0720	synthase
CU052_RS12570	COG2197	response regulator
CU052_RS12580	COG3300	MHYT domain
CU052_RS12580	COG5001	Diguanylate cyclase
CU052_RS12585	COG1760	l-serine dehydratase
CU052_RS12590	COG0814	amino acid
CU052_RS12605	COG0784	Response regulator, receiver
CU052_RS12605	COG2205	protein histidine kinase activity
CU052_RS12610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CU052_RS12625	COG3106	COG3106 Predicted ATPase
CU052_RS12640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU052_RS12780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CU052_RS12815	COG0277	FAD linked oxidase domain protein
CU052_RS12815	COG0247	lactate metabolic process
CU052_RS12830	COG2986	histidine ammonia-lyase
CU052_RS12840	COG0010	Belongs to the arginase family
CU052_RS12850	COG2188	Transcriptional regulator
CU052_RS12875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CU052_RS12885	COG0251	oxidation-reduction process
CU052_RS13040	COG1783	phage Terminase large subunit
CU052_RS13045	COG3567	Phage-associated protein, HI1409 family
CU052_RS13205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU052_RS13205	COG0072	phenylalanine-tRNA ligase activity
CU052_RS13270	COG1346	cytolysis
CU052_RS13280	COG2925	Exonuclease
CU052_RS13285	COG0662	Cupin 2, conserved barrel domain protein
CU052_RS13290	COG1280	lysine exporter protein (LysE YggA)
CU052_RS13295	COG1794	racemase activity, acting on amino acids and derivatives
CU052_RS13315	COG1823	symporter activity
CU052_RS13320	COG0702	epimerase
CU052_RS13325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU052_RS13335	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CU052_RS13345	COG2062	phosphohistidine phosphatase, SixA
CU052_RS13360	COG4139	cobalamin transport
CU052_RS13420	COG0583	DNA-binding transcription factor activity
CU052_RS13445	COG2165	general secretion pathway protein
CU052_RS13450	COG1451	nucleotide metabolic process
CU052_RS13480	COG3938	Belongs to the proline racemase family
CU052_RS13485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU052_RS13495	COG2423	ornithine cyclodeaminase activity
CU052_RS13500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU052_RS13505	COG3842	ATPase activity
CU052_RS13515	COG1177	transmembrane transport
CU052_RS13520	COG0813	purine-nucleoside phosphorylase activity
CU052_RS13540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU052_RS13545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU052_RS13555	COG0745	RESPONSE REGULATOR receiver
CU052_RS13595	COG0444	Belongs to the ABC transporter superfamily
CU052_RS13600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU052_RS13605	COG0601	transmembrane transport
CU052_RS13615	COG2195	Cleaves the N-terminal amino acid of tripeptides
CU052_RS13630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CU052_RS13640	COG0625	glutathione transferase activity
CU052_RS13695	COG1051	belongs to the nudix hydrolase family
CU052_RS13735	COG4565	transcriptional regulatory protein
CU052_RS13745	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CU052_RS13750	COG0511	ligase activity, forming carbon-carbon bonds
CU052_RS13750	COG5016	pyruvate
CU052_RS13755	COG3630	sodium ion export across plasma membrane
CU052_RS13765	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CU052_RS13775	COG2301	Belongs to the HpcH HpaI aldolase family
CU052_RS13780	COG3051	citrate lyase alpha subunit
CU052_RS13790	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CU052_RS13820	COG3284	Transcriptional regulator
CU052_RS13825	COG1012	belongs to the aldehyde dehydrogenase family
CU052_RS13830	COG1115	amino acid carrier protein
CU052_RS13865	COG1368	sulfuric ester hydrolase activity
CU052_RS13890	COG1404	Belongs to the peptidase S8 family
CU052_RS13895	COG0583	DNA-binding transcription factor activity
CU052_RS13915	COG2186	Transcriptional regulator
CU052_RS13955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CU052_RS13975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU052_RS13980	COG1999	signal sequence binding
CU052_RS13995	COG3005	denitrification pathway
CU052_RS14015	COG0583	DNA-binding transcription factor activity
CU052_RS14045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU052_RS14060	COG3290	protein histidine kinase activity
CU052_RS14065	COG4565	transcriptional regulatory protein
CU052_RS14070	COG4774	siderophore transport
CU052_RS14080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CU052_RS14085	COG0363	glucosamine-6-phosphate deaminase activity
CU052_RS14090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CU052_RS14120	COG5492	domain, Protein
CU052_RS14120	COG4932	domain protein
CU052_RS14125	COG1360	Flagellar Motor Protein
CU052_RS14165	COG2207	Transcriptional regulator
CU052_RS14190	COG4964	Belongs to the GSP D family
CU052_RS14265	COG1254	Belongs to the acylphosphatase family
CU052_RS14270	COG2920	part of a sulfur-relay system
CU052_RS14275	COG0670	Belongs to the BI1 family
CU052_RS14280	COG1126	abc transporter atp-binding protein
CU052_RS14285	COG0765	amino acid transport
CU052_RS14290	COG4597	amino acid ABC transporter
CU052_RS14295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU052_RS14315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CU052_RS14345	COG3008	intermembrane lipid transfer
CU052_RS14350	COG2995	paraquat-inducible protein a
CU052_RS14355	COG1132	(ABC) transporter
CU052_RS14360	COG1956	GAF domain-containing protein
CU052_RS14365	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CU052_RS14380	COG0308	aminopeptidase N
CU052_RS14390	COG2902	Dehydrogenase
CU052_RS14415	COG0488	(ABC) transporter
CU052_RS14430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU052_RS14435	COG1067	ATP-dependent peptidase activity
CU052_RS14460	COG2801	Transposase and inactivated derivatives
CU052_RS14465	COG2801	Transposase and inactivated derivatives
CU052_RS14470	COG2205	protein histidine kinase activity
CU052_RS14470	COG0784	Response regulator, receiver
CU052_RS14485	COG3278	Belongs to the heme-copper respiratory oxidase family
CU052_RS14500	COG2010	Cytochrome c
CU052_RS14510	COG2217	Heavy metal translocating P-type atpase
CU052_RS14525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU052_RS14530	COG0589	response to stress
CU052_RS14545	COG2992	FlgJ-related protein
CU052_RS14555	COG3842	ATPase activity
CU052_RS14565	COG1177	transmembrane transport
CU052_RS14575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CU052_RS14580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CU052_RS14600	COG0437	4 iron, 4 sulfur cluster binding
CU052_RS14605	COG3383	formate dehydrogenase (NAD+) activity
CU052_RS14605	COG0243	molybdopterin cofactor binding
CU052_RS14615	COG3381	protein complex oligomerization
CU052_RS14635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CU052_RS14640	COG0488	(ABC) transporter
CU052_RS14660	COG4191	Histidine kinase
CU052_RS14675	COG3842	ATPase activity
CU052_RS14685	COG0303	'Molybdopterin
CU052_RS14695	COG1940	carbohydrate kinase activity
CU052_RS14700	COG3148	PFAM DTW domain containing protein
CU052_RS14725	COG2801	Transposase and inactivated derivatives
CU052_RS14750	COG0840	transmembrane signaling receptor activity
CU052_RS14755	COG0791	NLP P60 protein
CU052_RS14765	COG3706	GGDEF domain
CU052_RS14770	COG2201	protein-glutamate methylesterase activity
CU052_RS14775	COG3001	Fructosamine kinase
CU052_RS14785	COG0307	riboflavin synthase, alpha
CU052_RS14790	COG0534	Mate efflux family protein
CU052_RS14800	COG1793	dna ligase
CU052_RS14830	COG2204	response regulator
CU052_RS14870	COG0297	glycogen (starch) synthase activity
CU052_RS14880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CU052_RS14890	COG3064	Membrane
CU052_RS14920	COG2199	diguanylate cyclase activity
CU052_RS14920	COG2203	Gaf domain
CU052_RS14930	COG0602	queuosine metabolic process
CU052_RS14935	COG0561	phosphatase activity
CU052_RS14960	COG2828	Protein conserved in bacteria
CU052_RS14970	COG0372	Belongs to the citrate synthase family
CU052_RS14975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CU052_RS15085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CU052_RS15095	COG0456	acetyltransferase
CU052_RS15120	COG0730	response to heat
CU052_RS15125	COG2358	TRAP transporter, solute receptor (TAXI family
CU052_RS15135	COG2801	Transposase and inactivated derivatives
CU052_RS15155	COG1280	lysine exporter protein (LysE YggA)
CU052_RS15190	COG2197	response regulator
CU052_RS15195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CU052_RS15205	COG1846	Transcriptional regulator
CU052_RS15220	COG1560	Kdo2-lipid A biosynthetic process
CU052_RS15225	COG0583	DNA-binding transcription factor activity
CU052_RS15230	COG1280	lysine exporter protein (LysE YggA)
CU052_RS15235	COG0531	amino acid
CU052_RS15260	COG3063	Type IV pilus biogenesis stability protein PilW
CU052_RS15285	COG1643	Atp-dependent helicase
CU052_RS15290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU052_RS15305	COG3302	dmso reductase anchor subunit
CU052_RS15310	COG0437	4 iron, 4 sulfur cluster binding
CU052_RS15315	COG0243	molybdopterin cofactor binding
CU052_RS15345	COG3706	GGDEF domain
CU052_RS15355	COG0443	Heat shock 70 kDa protein
CU052_RS15360	COG0443	Heat shock 70 kDa protein
CU052_RS15385	COG0583	DNA-binding transcription factor activity
CU052_RS15395	COG2165	general secretion pathway protein
CU052_RS15400	COG1132	(ABC) transporter
CU052_RS15405	COG1132	(ABC) transporter
CU052_RS15420	COG4774	siderophore transport
CU052_RS15425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU052_RS15430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU052_RS15435	COG1120	ATPase activity
CU052_RS15450	COG0814	amino acid
CU052_RS15455	COG1454	alcohol dehydrogenase
CU052_RS15465	COG3706	GGDEF domain
CU052_RS15475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CU052_RS15485	COG0861	Integral membrane protein TerC family
CU052_RS15495	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CU052_RS15500	COG1328	CTP reductase activity
CU052_RS15505	COG1280	lysine exporter protein (LysE YggA)
CU052_RS15515	COG3300	MHYT domain
CU052_RS15515	COG5001	Diguanylate cyclase
CU052_RS15525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU052_RS15525	COG4191	Histidine kinase
CU052_RS15530	COG0471	metal ion transport
CU052_RS15575	COG1643	Atp-dependent helicase
CU052_RS15585	COG2949	membrane
CU052_RS15590	COG0471	metal ion transport
CU052_RS15595	COG3706	GGDEF domain
CU052_RS15615	COG0492	ferredoxin-NADP+ reductase activity
CU052_RS15620	COG4988	ABC transporter
CU052_RS15625	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CU052_RS15635	COG2610	gluconate transmembrane transporter activity
CU052_RS15640	COG0583	DNA-binding transcription factor activity
CU052_RS15660	COG5002	protein histidine kinase activity
CU052_RS15660	COG3447	MASE1 domain protein
CU052_RS15660	COG5001	Diguanylate cyclase
CU052_RS15670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CU052_RS15680	COG4191	Histidine kinase
CU052_RS15680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU052_RS15695	COG3070	regulator of competence-specific genes
CU052_RS15710	COG2431	L-lysine efflux transmembrane transporter activity
CU052_RS15720	COG0076	glutamate decarboxylase activity
CU052_RS15725	COG1737	Transcriptional regulator
CU052_RS15735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CU052_RS15745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CU052_RS15775	COG4181	ATPase activity
CU052_RS15780	COG0534	Mate efflux family protein
CU052_RS15785	COG0702	epimerase
CU052_RS15790	COG1609	Transcriptional regulator
CU052_RS15800	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU052_RS15810	COG2814	Major facilitator Superfamily
CU052_RS15815	COG1187	pseudouridine synthase activity
CU052_RS15820	COG1061	Type III restriction enzyme res subunit
CU052_RS15880	COG3313	Fe-S protein
CU052_RS15890	COG0659	secondary active sulfate transmembrane transporter activity
CU052_RS15925	COG0398	Pfam SNARE associated Golgi protein
CU052_RS15930	COG4134	Bacterial extracellular solute-binding protein
CU052_RS15935	COG4135	transport system, permease component
CU052_RS15940	COG4136	ATPase activity
CU052_RS15945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CU052_RS15950	COG3604	Transcriptional regulator
CU052_RS15955	COG1151	hydroxylamine reductase activity
CU052_RS15960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU052_RS15970	COG0564	pseudouridine synthase activity
CU052_RS15980	COG0733	neurotransmitter:sodium symporter activity
CU052_RS15990	COG0626	cystathionine gamma-synthase activity
CU052_RS15995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CU052_RS16005	COG2818	Glycosylase
CU052_RS16035	COG1842	Phage shock protein A
CU052_RS16040	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CU052_RS16055	COG4171	peptide transport system, permease
CU052_RS16065	COG4172	Belongs to the ABC transporter superfamily
CU052_RS16075	COG1227	inorganic diphosphatase activity
CU052_RS16080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU052_RS16085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU052_RS16090	COG1121	(ABC) transporter
CU052_RS16105	COG0243	molybdopterin cofactor binding
CU052_RS16110	COG3005	denitrification pathway
CU052_RS16115	COG4459	periplasmic nitrate reductase
CU052_RS16120	COG0390	transport system, permease component
CU052_RS16125	COG2116	formate transmembrane transporter activity
CU052_RS16155	COG1435	thymidine kinase activity
CU052_RS16160	COG0215	cysteine-tRNA ligase activity
CU052_RS16165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CU052_RS16170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CU052_RS16175	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CU052_RS16180	COG3012	SEC-C Motif Domain Protein
CU052_RS16185	COG0140	phosphoribosyl-ATP diphosphatase activity
CU052_RS16185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CU052_RS16195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CU052_RS16200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CU052_RS16205	COG0131	Imidazoleglycerol-phosphate dehydratase
CU052_RS16205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CU052_RS16210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU052_RS16215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CU052_RS16225	COG1757	Na H antiporter
CU052_RS16235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU052_RS16245	COG0482	sulfurtransferase activity
CU052_RS16255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CU052_RS16265	COG2268	Band 7 protein
CU052_RS16275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU052_RS16290	COG0300	oxidoreductase activity
CU052_RS16330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU052_RS16335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CU052_RS16355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CU052_RS16365	COG1674	ftsk spoiiie
CU052_RS16375	COG0686	Belongs to the AlaDH PNT family
CU052_RS16550	COG2801	Transposase and inactivated derivatives
CU052_RS16565	COG4934	collagen metabolic process
CU052_RS16575	COG2963	transposase activity
CU052_RS16595	COG4584	PFAM Integrase catalytic
CU052_RS16615	COG0457	Tetratricopeptide repeat
CU052_RS16685	COG4790	Type iii secretion
CU052_RS16690	COG4794	Type iii secretion
CU052_RS16695	COG4791	protein targeting
CU052_RS16700	COG4792	protein secretion
CU052_RS16745	COG4669	(LipO)protein
CU052_RS16830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CU052_RS16840	COG2801	Transposase and inactivated derivatives
CU052_RS16850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CU052_RS16870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CU052_RS16920	COG2003	Belongs to the UPF0758 family
CU052_RS16965	COG0582	viral genome integration into host DNA
CU052_RS16980	COG5002	protein histidine kinase activity
CU052_RS16980	COG0784	Response regulator, receiver
CU052_RS16990	COG0754	glutathionylspermidine amidase activity
CU052_RS17000	COG3766	membrane
CU052_RS17020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU052_RS17025	COG0371	Dehydrogenase
CU052_RS17030	COG2207	Transcriptional regulator
CU052_RS17035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS17040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CU052_RS17045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU052_RS17050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CU052_RS17055	COG1882	Formate acetyltransferase
CU052_RS17060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS17070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU052_RS17070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS17070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS17075	COG0673	inositol 2-dehydrogenase activity
CU052_RS17090	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CU052_RS17095	COG2885	chlorophyll binding
CU052_RS17100	COG0823	Involved in the tonB-independent uptake of proteins
CU052_RS17115	COG0811	peptide transport
CU052_RS17120	COG0824	Thioesterase
CU052_RS17130	COG4890	Cyd operon protein YbgT
CU052_RS17135	COG1294	oxidase, subunit
CU052_RS17140	COG1271	oxidase subunit
CU052_RS17150	COG0632	four-way junction helicase activity
CU052_RS17155	COG0840	transmembrane signaling receptor activity
CU052_RS17170	COG1801	Protein of unknown function DUF72
CU052_RS17190	COG4067	protein conserved in archaea
CU052_RS17190	COG0189	ligase activity
CU052_RS17210	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CU052_RS17215	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CU052_RS17225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU052_RS17230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CU052_RS17235	COG0745	RESPONSE REGULATOR receiver
CU052_RS17250	COG3070	regulator of competence-specific genes
CU052_RS17270	COG0297	glycogen (starch) synthase activity
CU052_RS17275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU052_RS17280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU052_RS17310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CU052_RS17315	COG0542	response to heat
CU052_RS17325	COG1278	Cold shock
CU052_RS17335	COG1187	pseudouridine synthase activity
CU052_RS17340	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CU052_RS17350	COG1199	ATP-dependent helicase activity
CU052_RS17355	COG0730	response to heat
CU052_RS17370	COG0840	transmembrane signaling receptor activity
CU052_RS17375	COG0708	Exodeoxyribonuclease III
CU052_RS17415	COG1882	Formate acetyltransferase
CU052_RS17425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CU052_RS17445	COG2766	serine protein kinase
CU052_RS17450	COG2718	Belongs to the UPF0229 family
CU052_RS17460	COG3537	Alpha-1,2-mannosidase
CU052_RS17470	COG3537	Alpha-1,2-mannosidase
CU052_RS17475	COG3537	Alpha-1,2-mannosidase
CU052_RS17480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS17495	COG0561	phosphatase activity
CU052_RS17510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU052_RS17520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CU052_RS17525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CU052_RS17530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU052_RS17535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS17535	COG1263	PTS System
CU052_RS17545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU052_RS17545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU052_RS17550	COG0346	lactoylglutathione lyase activity
CU052_RS17555	COG1349	DNA-binding transcription factor activity
CU052_RS17560	COG1609	Transcriptional regulator
CU052_RS17565	COG1263	PTS System
CU052_RS17565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS17570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CU052_RS17595	COG0753	catalase activity
CU052_RS17610	COG1335	isochorismatase
CU052_RS17635	COG3136	membrane protein required for alginate biosynthesis
CU052_RS17675	COG0589	response to stress
CU052_RS17680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CU052_RS17695	COG3448	diguanylate cyclase activity
CU052_RS17695	COG4175	Glycine betaine
CU052_RS17700	COG4176	ABC-type proline glycine betaine transport system permease component
CU052_RS17710	COG1342	Belongs to the UPF0251 family
CU052_RS17740	COG4948	Mandelate Racemase Muconate Lactonizing
CU052_RS17755	COG0668	transmembrane transport
CU052_RS17765	COG1304	FMN binding
CU052_RS17770	COG1620	l-lactate permease
CU052_RS17775	COG0583	DNA-binding transcription factor activity
CU052_RS17795	COG4172	Belongs to the ABC transporter superfamily
CU052_RS17805	COG1067	ATP-dependent peptidase activity
CU052_RS17835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU052_RS17840	COG0437	4 iron, 4 sulfur cluster binding
CU052_RS17845	COG0348	domain, Protein
CU052_RS17865	COG1122	ATPase activity
CU052_RS17875	COG1566	PFAM secretion protein HlyD family protein
CU052_RS17905	COG0813	purine-nucleoside phosphorylase activity
CU052_RS17915	COG3272	Protein of unknown function (DUF1722)
CU052_RS17920	COG0789	Transcriptional regulator
CU052_RS17925	COG0415	Belongs to the DNA photolyase family
CU052_RS17930	COG1388	LysM domain
CU052_RS17930	COG1376	ErfK ybiS ycfS ynhG family protein
CU052_RS17940	COG0513	Belongs to the DEAD box helicase family
CU052_RS17950	COG0840	transmembrane signaling receptor activity
CU052_RS17960	COG0573	inorganic phosphate transmembrane transporter activity
CU052_RS17965	COG0581	inorganic phosphate transmembrane transporter activity
CU052_RS17970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CU052_RS17985	COG2304	oxidoreductase activity
CU052_RS18005	COG0714	Associated with various cellular activities
CU052_RS18010	COG0840	transmembrane signaling receptor activity
CU052_RS18045	COG0110	maltose O-acetyltransferase activity
CU052_RS18055	COG4191	Histidine kinase
CU052_RS18065	COG2801	Transposase and inactivated derivatives
CU052_RS18075	COG0573	inorganic phosphate transmembrane transporter activity
CU052_RS18085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CU052_RS18090	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS18105	COG3344	reverse transcriptase
CU052_RS18140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CU052_RS18145	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CU052_RS18155	COG1252	NADH dehydrogenase
CU052_RS18180	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU052_RS18200	COG3383	formate dehydrogenase (NAD+) activity
CU052_RS18225	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CU052_RS18235	COG4145	pantothenate transmembrane transporter activity
CU052_RS18240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU052_RS18245	COG0800	Aldolase
CU052_RS18260	COG0251	oxidation-reduction process
CU052_RS18265	COG0842	Transport permease protein
CU052_RS18270	COG1131	(ABC) transporter
CU052_RS18280	COG0840	transmembrane signaling receptor activity
CU052_RS18285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CU052_RS18290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU052_RS18300	COG0848	biopolymer transport protein
CU052_RS18305	COG0811	peptide transport
CU052_RS18310	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CU052_RS18320	COG3721	Heme iron utilization protein
CU052_RS18325	COG0748	coenzyme F420 binding
CU052_RS18335	COG0835	chemotaxis
CU052_RS18335	COG0784	Response regulator, receiver
CU052_RS18340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU052_RS18355	COG0366	Alpha amylase catalytic
CU052_RS18410	COG0583	DNA-binding transcription factor activity
CU052_RS18425	COG2249	NAD(P)H dehydrogenase (quinone) activity
CU052_RS18440	COG1881	PFAM PEBP family protein
CU052_RS18455	COG0798	PFAM Bile acid sodium symporter
CU052_RS18470	COG1733	regulation of RNA biosynthetic process
CU052_RS18480	COG0747	negative chemotaxis
CU052_RS18485	COG1482	cell wall glycoprotein biosynthetic process
CU052_RS18490	COG0383	alpha-mannosidase activity
CU052_RS18495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS18495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS18495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS18500	COG2188	Transcriptional regulator
CU052_RS18505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS18510	COG2213	PTS system mannitol-specific
CU052_RS18515	COG1063	alcohol dehydrogenase
CU052_RS18525	COG1072	(Pantothenic acid kinase))
CU052_RS18530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CU052_RS18550	COG0814	amino acid
CU052_RS18565	COG3314	Sporulation integral membrane protein YlbJ
CU052_RS18590	COG0739	heme binding
CU052_RS18595	COG5001	Diguanylate cyclase
CU052_RS18600	COG0583	DNA-binding transcription factor activity
CU052_RS18605	COG2814	Major facilitator Superfamily
CU052_RS18625	COG0697	spore germination
CU052_RS18640	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU052_RS18660	COG1280	lysine exporter protein (LysE YggA)
CU052_RS18670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU052_RS18685	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CU052_RS18690	COG1845	cytochrome c oxidase, subunit III
CU052_RS18710	COG1612	heme a metabolic process
CU052_RS18725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CU052_RS18730	COG2814	Major facilitator Superfamily
CU052_RS18740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CU052_RS18770	COG2897	thiosulfate sulfurtransferase activity
CU052_RS18790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU052_RS18800	COG2801	Transposase and inactivated derivatives
CU052_RS18815	COG1914	H( )-stimulated, divalent metal cation uptake system
CU052_RS18840	COG4989	oxidoreductase activity
CU052_RS18855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CU052_RS18855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CU052_RS18870	COG1073	alpha beta
CU052_RS18875	COG0583	DNA-binding transcription factor activity
CU052_RS18895	COG4964	Belongs to the GSP D family
CU052_RS18905	COG0455	bacterial-type flagellum organization
CU052_RS18945	COG2885	chlorophyll binding
CU052_RS18980	COG2801	Transposase and inactivated derivatives
CU052_RS18995	COG0402	S-adenosylhomocysteine deaminase activity
CU052_RS19040	COG4176	ABC-type proline glycine betaine transport system permease component
CU052_RS19045	COG0517	IMP dehydrogenase activity
CU052_RS19045	COG4175	Glycine betaine
CU052_RS19060	COG0330	HflC and HflK could
CU052_RS19090	COG2205	protein histidine kinase activity
CU052_RS19090	COG0784	Response regulator, receiver
CU052_RS19130	COG0586	Pfam SNARE associated Golgi protein
CU052_RS19150	COG2801	Transposase and inactivated derivatives
CU052_RS19160	COG1794	racemase activity, acting on amino acids and derivatives
CU052_RS19165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CU052_RS19180	COG1129	ABC transporter
CU052_RS19185	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU052_RS19190	COG1879	ABC-type sugar transport system periplasmic component
CU052_RS19195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU052_RS19200	COG1609	Transcriptional regulator
CU052_RS19215	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CU052_RS19230	COG4607	ABC-type enterochelin transport system periplasmic component
CU052_RS19235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU052_RS19240	COG4605	iron ion homeostasis
CU052_RS19245	COG4604	ABC transporter, ATP-binding protein
CU052_RS19250	COG0789	Transcriptional regulator
CU052_RS19270	COG4206	TonB-dependent receptor
CU052_RS19295	COG0523	cobalamin synthesis protein
CU052_RS19300	COG5002	protein histidine kinase activity
CU052_RS19300	COG3447	MASE1 domain protein
CU052_RS19300	COG5001	Diguanylate cyclase
CU052_RS19305	COG0513	Belongs to the DEAD box helicase family
CU052_RS19325	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CU052_RS19330	COG1119	ATPase activity
CU052_RS19345	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CU052_RS19365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU052_RS19370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU052_RS19480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CU052_RS19495	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CU052_RS19500	COG0513	Belongs to the DEAD box helicase family
CU052_RS19510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CU052_RS19515	COG0583	DNA-binding transcription factor activity
CU052_RS19525	COG1012	belongs to the aldehyde dehydrogenase family
CU052_RS19535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU052_RS19570	COG1126	abc transporter atp-binding protein
CU052_RS19575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU052_RS19580	COG4215	(ABC) transporter
CU052_RS19585	COG4160	amino acid transport
CU052_RS19610	COG3976	FMN-binding domain protein
CU052_RS19610	COG1053	succinate dehydrogenase
CU052_RS19610	COG0431	NADPH-dependent FMN reductase
CU052_RS19660	COG0443	Heat shock 70 kDa protein
CU052_RS19665	COG2847	Copper chaperone PCu(A)C
CU052_RS19695	COG0745	RESPONSE REGULATOR receiver
CU052_RS19710	COG1785	Belongs to the alkaline phosphatase family
CU052_RS19730	COG3706	GGDEF domain
CU052_RS19740	COG0814	amino acid
CU052_RS19745	COG5001	Diguanylate cyclase
CU052_RS19745	COG5002	protein histidine kinase activity
CU052_RS19755	COG0243	molybdopterin cofactor binding
CU052_RS19765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CU052_RS19775	COG3707	response regulator
CU052_RS19785	COG1116	anion transmembrane transporter activity
CU052_RS19785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU052_RS19790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU052_RS19795	COG1116	anion transmembrane transporter activity
CU052_RS19800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU052_RS19800	COG2146	nitrite reductase [NAD(P)H] activity
CU052_RS19850	COG0739	heme binding
CU052_RS19860	COG3038	cytochrome b561
CU052_RS19885	COG0745	RESPONSE REGULATOR receiver
CU052_RS19905	COG0628	permease
CU052_RS19910	COG1024	Enoyl-CoA hydratase
CU052_RS19990	COG2067	long-chain fatty acid transport protein
CU052_RS19995	COG1234	tRNA 3'-trailer cleavage
CU052_RS20010	COG5642	Protein of unknown function (DUF2384)
CU052_RS20025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CU052_RS20025	COG2755	lipolytic protein G-D-S-L family
CU052_RS20035	COG1902	pentaerythritol trinitrate reductase activity
CU052_RS20040	COG0346	lactoylglutathione lyase activity
CU052_RS20065	COG2815	serine threonine protein kinase
CU052_RS20065	COG0515	serine threonine protein kinase
CU052_RS20100	COG0631	protein serine/threonine phosphatase activity
CU052_RS20170	COG3209	COG3209 Rhs family protein
CU052_RS20195	COG0420	3'-5' exonuclease activity
CU052_RS20200	COG0419	ATPase involved in DNA repair
CU052_RS20245	COG3040	lipid binding
CU052_RS20255	COG2814	Major facilitator Superfamily
CU052_RS20265	COG1288	antiporter activity
CU052_RS20275	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CU052_RS20290	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CU052_RS20300	COG0583	DNA-binding transcription factor activity
CU052_RS20305	COG0277	FAD linked oxidase domain protein
CU052_RS20380	COG5001	Diguanylate cyclase
CU052_RS20385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU052_RS20395	COG2116	formate transmembrane transporter activity
CU052_RS20415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CU052_RS20450	COG2205	protein histidine kinase activity
CU052_RS20450	COG0745	RESPONSE REGULATOR receiver
CU052_RS20450	COG3292	Two component regulator propeller
CU052_RS20460	COG3118	belongs to the thioredoxin family
CU052_RS20465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU052_RS20490	COG1566	PFAM secretion protein HlyD family protein
CU052_RS20500	COG0628	permease
CU052_RS20510	COG1482	cell wall glycoprotein biosynthetic process
CU052_RS20515	COG2271	Major facilitator Superfamily
CU052_RS20520	COG3851	Histidine kinase
CU052_RS20525	COG2197	response regulator
CU052_RS20585	COG1328	CTP reductase activity
CU052_RS20590	COG0602	queuosine metabolic process
CU052_RS20595	COG0534	Mate efflux family protein
CU052_RS20610	COG0189	ligase activity
CU052_RS20610	COG4067	protein conserved in archaea
CU052_RS20620	COG3111	PFAM Bacterial OB fold (BOF) protein
CU052_RS20630	COG0725	ABC transporter, periplasmic molybdate-binding protein
CU052_RS20635	COG4149	molybdate abc transporter
CU052_RS20640	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CU052_RS20650	COG2203	Gaf domain
CU052_RS20650	COG4251	negative regulation of phosphorylation
CU052_RS20650	COG3706	GGDEF domain
CU052_RS20650	COG5001	Diguanylate cyclase
CU052_RS20665	COG3706	GGDEF domain
CU052_RS20680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CU052_RS20685	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CU052_RS20710	COG3140	Belongs to the UPF0181 family
CU052_RS20740	COG0023	Translation Initiation Factor
CU052_RS20760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU052_RS20760	COG0045	succinate-CoA ligase (ADP-forming) activity
CU052_RS20760	COG1042	CoA-binding domain protein
CU052_RS20770	COG0583	DNA-binding transcription factor activity
CU052_RS20785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU052_RS20790	COG3447	MASE1 domain protein
CU052_RS20790	COG5001	Diguanylate cyclase
CU052_RS20790	COG5002	protein histidine kinase activity
CU052_RS20800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CU052_RS20805	COG1984	allophanate hydrolase subunit 2
CU052_RS20815	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CU052_RS20820	COG4181	ATPase activity
CU052_RS20830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CU052_RS20835	COG5001	Diguanylate cyclase
CU052_RS20835	COG3300	MHYT domain
CU052_RS20845	COG0484	heat shock protein binding
CU052_RS20880	COG2050	protein possibly involved in aromatic compounds catabolism
CU052_RS20895	COG2067	long-chain fatty acid transport protein
CU052_RS20900	COG2267	carboxylic ester hydrolase activity
CU052_RS20935	COG0737	Belongs to the 5'-nucleotidase family
CU052_RS20940	COG3593	DNA synthesis involved in DNA repair
CU052_RS20950	COG0583	DNA-binding transcription factor activity
CU052_RS20960	COG2116	formate transmembrane transporter activity
CU052_RS20970	COG3038	cytochrome b561
CU052_RS20985	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CU052_RS20990	COG0513	Belongs to the DEAD box helicase family
CU052_RS21020	COG0546	phosphoglycolate phosphatase activity
CU052_RS21025	COG3437	response regulator, receiver
CU052_RS21025	COG0784	Response regulator, receiver
CU052_RS21040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU052_RS21050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU052_RS21060	COG2207	Transcriptional regulator
CU052_RS21065	COG1979	alcohol dehydrogenase
CU052_RS21075	COG1126	abc transporter atp-binding protein
CU052_RS21080	COG0765	amino acid transport
CU052_RS21085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU052_RS21090	COG0765	amino acid transport
CU052_RS21095	COG2200	EAL domain
CU052_RS21095	COG2199	diguanylate cyclase activity
CU052_RS21095	COG2203	Gaf domain
CU052_RS21110	COG1609	Transcriptional regulator
CU052_RS21115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS21115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS21120	COG1105	Belongs to the carbohydrate kinase PfkB family
CU052_RS21125	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CU052_RS21125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS21125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS21155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU052_RS21160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU052_RS21170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CU052_RS21180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CU052_RS21185	COG0509	glycine decarboxylation via glycine cleavage system
CU052_RS21200	COG2801	Transposase and inactivated derivatives
CU052_RS21300	COG2176	DNA-directed DNA polymerase activity
CU052_RS21310	COG1733	regulation of RNA biosynthetic process
CU052_RS21325	COG1132	(ABC) transporter
CU052_RS21370	COG0671	phosphoesterase, PA-phosphatase related
CU052_RS21375	COG1902	pentaerythritol trinitrate reductase activity
CU052_RS21375	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU052_RS21385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CU052_RS21390	COG1845	cytochrome c oxidase, subunit III
CU052_RS21395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU052_RS21400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CU052_RS21410	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS21420	COG1024	Enoyl-CoA hydratase
CU052_RS21425	COG1024	Enoyl-CoA hydratase
CU052_RS21440	COG0183	Belongs to the thiolase family
CU052_RS21450	COG1960	acyl-CoA dehydrogenase activity
CU052_RS21455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU052_RS21460	COG1024	Enoyl-CoA hydratase
CU052_RS21500	COG3278	Belongs to the heme-copper respiratory oxidase family
CU052_RS21525	COG2962	Rard protein
CU052_RS21535	COG2165	general secretion pathway protein
CU052_RS21540	COG0784	Response regulator, receiver
CU052_RS21540	COG0835	chemotaxis
CU052_RS21550	COG0778	Nitroreductase
CU052_RS21560	COG2197	response regulator
CU052_RS21570	COG3706	GGDEF domain
CU052_RS21575	COG2197	response regulator
CU052_RS21580	COG5001	Diguanylate cyclase
CU052_RS21580	COG3300	MHYT domain
CU052_RS21585	COG2205	protein histidine kinase activity
CU052_RS21585	COG0784	Response regulator, receiver
CU052_RS21600	COG4771	TonB-dependent receptor
CU052_RS21605	COG1120	ATPase activity
CU052_RS21610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU052_RS21615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU052_RS21620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CU052_RS21625	COG4772	TonB-dependent receptor
CU052_RS21650	COG4264	IucA IucC family
CU052_RS21655	COG0019	diaminopimelate decarboxylase activity
CU052_RS21660	COG2017	converts alpha-aldose to the beta-anomer
CU052_RS21665	COG1940	carbohydrate kinase activity
CU052_RS21670	COG0477	Major facilitator Superfamily
CU052_RS21670	COG2814	Major facilitator Superfamily
CU052_RS21675	COG0457	Tetratricopeptide repeat
CU052_RS21685	COG2801	Transposase and inactivated derivatives
CU052_RS21695	COG0739	heme binding
CU052_RS21700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CU052_RS21730	COG3069	C4-dicarboxylate transmembrane transporter activity
CU052_RS21735	COG1704	LemA family
CU052_RS21740	COG0501	Belongs to the peptidase M48B family
CU052_RS21765	COG0641	radical SAM
CU052_RS21785	COG3111	PFAM Bacterial OB fold (BOF) protein
CU052_RS21790	COG1597	lipid kinase activity
CU052_RS21795	COG0583	DNA-binding transcription factor activity
CU052_RS21805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CU052_RS21815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CU052_RS21875	COG0714	Associated with various cellular activities
CU052_RS21885	COG3119	arylsulfatase activity
CU052_RS21890	COG3119	arylsulfatase activity
CU052_RS21920	COG2205	protein histidine kinase activity
CU052_RS21920	COG2198	Histidine kinase
CU052_RS21920	COG0784	Response regulator, receiver
CU052_RS21925	COG1879	ABC-type sugar transport system periplasmic component
CU052_RS21935	COG0210	DNA helicase
CU052_RS21940	COG1289	transmembrane transporter activity
CU052_RS21975	COG3530	Putative quorum-sensing-regulated virulence factor
CU052_RS22015	COG3186	Phenylalanine-4-hydroxylase
CU052_RS22025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU052_RS22030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU052_RS22050	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CU052_RS22060	COG1454	alcohol dehydrogenase
CU052_RS22065	COG2133	pyrroloquinoline quinone binding
CU052_RS22070	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU052_RS22080	COG0783	Belongs to the Dps family
CU052_RS22085	COG0840	transmembrane signaling receptor activity
CU052_RS22110	COG2205	protein histidine kinase activity
CU052_RS22110	COG0784	Response regulator, receiver
CU052_RS22115	COG1538	Outer membrane efflux protein
CU052_RS22145	COG1136	(ABC) transporter
CU052_RS22145	COG0577	efflux transmembrane transporter activity
CU052_RS22165	COG2199	diguanylate cyclase activity
CU052_RS22175	COG3036	rescue of stalled ribosome
CU052_RS22180	COG1278	Cold shock
CU052_RS22245	COG3504	Conjugal transfer protein
CU052_RS22305	COG3730	PTS system glucitol sorbitol-specific
CU052_RS22310	COG1349	DNA-binding transcription factor activity
CU052_RS22315	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS22320	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS22335	COG3730	PTS system glucitol sorbitol-specific
CU052_RS22340	COG0517	IMP dehydrogenase activity
CU052_RS22340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CU052_RS22360	COG4991	sh3 domain protein
CU052_RS22360	COG0515	serine threonine protein kinase
CU052_RS22360	COG3064	Membrane
CU052_RS22385	COG1716	ATPase activity
CU052_RS22405	COG1181	Belongs to the D-alanine--D-alanine ligase family
CU052_RS22560	COG4932	domain protein
CU052_RS22560	COG2373	Large extracellular alpha-helical protein
CU052_RS22560	COG1388	LysM domain
CU052_RS22570	COG3969	phosphoadenosine phosphosulfate
CU052_RS22575	COG1475	DNA binding
CU052_RS22605	COG3152	Membrane
CU052_RS22630	COG1742	UPF0060 membrane protein
CU052_RS22635	COG4974	Belongs to the 'phage' integrase family
CU052_RS22645	COG2885	chlorophyll binding
CU052_RS22655	COG0545	Peptidyl-prolyl cis-trans isomerase
CU052_RS22685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU052_RS22695	COG0840	transmembrane signaling receptor activity
CU052_RS22715	COG2195	Cleaves the N-terminal amino acid of tripeptides
CU052_RS22730	COG2197	response regulator
CU052_RS22735	COG3850	Histidine kinase
CU052_RS22740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CU052_RS22760	COG3005	denitrification pathway
CU052_RS22785	COG0183	Belongs to the thiolase family
CU052_RS22795	COG1280	lysine exporter protein (LysE YggA)
CU052_RS22805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU052_RS22810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU052_RS22880	COG2926	Belongs to the UPF0265 family
CU052_RS22885	COG0534	Mate efflux family protein
CU052_RS22890	COG0673	inositol 2-dehydrogenase activity
CU052_RS22900	COG5002	protein histidine kinase activity
CU052_RS22900	COG2205	protein histidine kinase activity
CU052_RS22900	COG0784	Response regulator, receiver
CU052_RS22920	COG0583	DNA-binding transcription factor activity
CU052_RS22930	COG1522	sequence-specific DNA binding
CU052_RS22935	COG0531	amino acid
CU052_RS22940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU052_RS22950	COG2205	protein histidine kinase activity
CU052_RS22955	COG0745	RESPONSE REGULATOR receiver
CU052_RS22980	COG1566	PFAM secretion protein HlyD family protein
CU052_RS22985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CU052_RS22990	COG2239	Acts as a magnesium transporter
CU052_RS22995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CU052_RS23000	COG0402	S-adenosylhomocysteine deaminase activity
CU052_RS23015	COG1418	mRNA catabolic process
CU052_RS23030	COG2814	Major facilitator Superfamily
CU052_RS23040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU052_RS23060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CU052_RS23075	COG4221	oxidoreductase activity
CU052_RS23090	COG3976	FMN-binding domain protein
CU052_RS23090	COG1053	succinate dehydrogenase
CU052_RS23095	COG4948	Mandelate Racemase Muconate Lactonizing
CU052_RS23100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU052_RS23105	COG0745	RESPONSE REGULATOR receiver
CU052_RS23110	COG2205	protein histidine kinase activity
CU052_RS23120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CU052_RS23125	COG2194	sulfuric ester hydrolase activity
CU052_RS23135	COG4977	sequence-specific DNA binding
CU052_RS23140	COG1335	isochorismatase
CU052_RS23150	COG2814	Major facilitator Superfamily
CU052_RS23170	COG0583	DNA-binding transcription factor activity
CU052_RS23210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CU052_RS23220	COG3217	Mosc domain protein beta barrel domain protein
CU052_RS23220	COG0633	Ferredoxin
CU052_RS23220	COG0633	Ferredoxin
CU052_RS23220	COG3217	Mosc domain protein beta barrel domain protein
CU052_RS23225	COG0401	homolog of Blt101
CU052_RS23240	COG2354	Protein conserved in bacteria
CU052_RS23265	COG0741	lytic transglycosylase activity
CU052_RS23310	COG3833	ABC-type maltose transport systems, permease component
CU052_RS23315	COG1175	transmembrane transport
CU052_RS23330	COG3842	ATPase activity
CU052_RS23350	COG3206	protein involved in exopolysaccharide biosynthesis
CU052_RS23350	COG0489	protein tyrosine kinase activity
CU052_RS23360	COG0438	transferase activity, transferring glycosyl groups
CU052_RS23390	COG1309	transcriptional regulator
CU052_RS23395	COG2130	NADP-dependent
CU052_RS23405	COG0753	catalase activity
CU052_RS23410	COG2084	Dehydrogenase
CU052_RS23420	COG0583	DNA-binding transcription factor activity
CU052_RS23425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS23430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS23440	COG2207	Transcriptional regulator
CU052_RS23445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS23445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS23445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU052_RS23460	COG0583	DNA-binding transcription factor activity
CU052_RS23465	COG1566	PFAM secretion protein HlyD family protein
CU052_RS23500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU052_RS23510	COG0583	DNA-binding transcription factor activity
CU052_RS23515	COG2207	Transcriptional regulator
CU052_RS23515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU052_RS23520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU052_RS23540	COG0095	Lipoate-protein ligase
CU052_RS23560	COG0513	Belongs to the DEAD box helicase family
CU052_RS23565	COG2801	Transposase and inactivated derivatives
CU052_RS23575	COG0583	DNA-binding transcription factor activity
CU052_RS23600	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS23605	COG2814	Major facilitator Superfamily
CU052_RS23615	COG1902	pentaerythritol trinitrate reductase activity
CU052_RS23630	COG3122	Protein conserved in bacteria
CU052_RS23650	COG0583	DNA-binding transcription factor activity
CU052_RS23655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CU052_RS23665	COG0252	asparaginase activity
CU052_RS23675	COG0574	Belongs to the PEP-utilizing enzyme family
CU052_RS23675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU052_RS23685	COG2197	response regulator
CU052_RS23690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CU052_RS23705	COG0583	DNA-binding transcription factor activity
CU052_RS23710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU052_RS23720	COG1538	Outer membrane efflux protein
CU052_RS23725	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CU052_RS23730	COG0786	glutamate:sodium symporter activity
CU052_RS23765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU052_RS23775	COG2801	Transposase and inactivated derivatives
CU052_RS23820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU052_RS23830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU052_RS23870	COG3338	carbonate dehydratase activity
CU052_RS23900	COG1063	alcohol dehydrogenase
CU052_RS23905	COG0156	8-amino-7-oxononanoate synthase activity
CU052_RS23930	COG0745	RESPONSE REGULATOR receiver
CU052_RS23955	COG0346	lactoylglutathione lyase activity
CU052_RS24000	COG2200	EAL domain
CU052_RS24060	COG1987	bacterial-type flagellum assembly
CU052_RS24070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CU052_RS24085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU052_RS24095	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CU052_RS24100	COG1516	flagellar protein fliS
CU052_RS24115	COG1580	Controls the rotational direction of flagella during chemotaxis
CU052_RS24120	COG1191	sigma factor activity
CU052_RS24125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CU052_RS24130	COG1360	Flagellar Motor Protein
CU052_RS24180	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CU052_RS24195	COG1136	(ABC) transporter
CU052_RS24205	COG1136	(ABC) transporter
CU052_RS24205	COG0577	efflux transmembrane transporter activity
CU052_RS24220	COG0672	)-iron permease
CU052_RS24240	COG2226	methyltransferase
CU052_RS24255	COG3710	Transcriptional regulator
CU052_RS24260	COG1253	flavin adenine dinucleotide binding
CU052_RS24295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU052_RS24300	COG4786	Flagellar basal body rod
CU052_RS24300	COG1256	bacterial-type flagellum assembly
CU052_RS24310	COG1706	bacterial-type flagellum-dependent cell motility
CU052_RS24315	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CU052_RS24320	COG4786	Flagellar basal body rod
CU052_RS24325	COG4787	bacterial-type flagellum-dependent cell motility
CU052_RS24330	COG1749	Flagellar hook protein flgE
CU052_RS24340	COG1558	bacterial-type flagellum-dependent cell motility
CU052_RS24345	COG1815	bacterial-type flagellum-dependent cell motility
CU052_RS24365	COG0741	lytic transglycosylase activity
CU052_RS24365	COG1388	LysM domain
CU052_RS24390	COG2801	Transposase and inactivated derivatives
CU052_RS24400	COG1760	l-serine dehydratase
CU052_RS24405	COG3104	oligopeptide transport
CU052_RS24430	COG0583	DNA-binding transcription factor activity
CU052_RS24440	COG2866	Carboxypeptidase
CU052_RS24445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU052_RS24460	COG2990	Protein conserved in bacteria
CU052_RS24485	COG3842	ATPase activity
CU052_RS24490	COG1840	ABC-type Fe3 transport system, periplasmic component
CU052_RS24500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CU052_RS24510	COG1609	Transcriptional regulator
CU052_RS24540	COG3240	lipase activity
CU052_RS24575	COG1011	Hydrolase
CU052_RS24625	COG1765	OsmC-like protein
CU052_RS24655	COG1765	OsmC-like protein
CU052_RS24660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU052_RS24660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU052_RS24675	COG3046	protein related to deoxyribodipyrimidine photolyase
CU052_RS24680	COG0415	Belongs to the DNA photolyase family
CU052_RS24685	COG3706	GGDEF domain
CU052_RS24700	COG3706	GGDEF domain
CU052_RS24720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU052_RS24725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU052_RS24745	COG3033	Beta-eliminating lyase
CU052_RS24765	COG3179	chitinase
CU052_RS24775	COG0579	oxidoreductase
CU052_RS24800	COG1114	Component of the transport system for branched-chain amino acids
CU052_RS24840	COG0583	DNA-binding transcription factor activity
CU052_RS24865	COG0189	ligase activity
CU052_RS24870	COG0189	ligase activity
CU052_RS24870	COG4067	protein conserved in archaea
CU052_RS24880	COG1166	arginine decarboxylase activity
CU052_RS24885	COG0010	Belongs to the arginase family
CU052_RS24890	COG2814	Major facilitator Superfamily
CU052_RS24895	COG1770	oligopeptidase
CU052_RS24910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU052_RS24915	COG1121	(ABC) transporter
CU052_RS24920	COG0803	Belongs to the bacterial solute-binding protein 9 family
CU052_RS24965	COG0848	biopolymer transport protein
CU052_RS24970	COG0811	peptide transport
CU052_RS24975	COG0811	peptide transport
CU052_RS24995	COG0745	RESPONSE REGULATOR receiver
CU052_RS25000	COG0039	L-malate dehydrogenase activity
CU052_RS25005	COG0584	glycerophosphoryl diester phosphodiesterase
CU052_RS25015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CU052_RS25070	COG0312	modulator of DNA gyrase
CU052_RS25075	COG0312	modulator of DNA gyrase
CU052_RS25080	COG0351	phosphomethylpyrimidine kinase
CU052_RS25085	COG1116	anion transmembrane transporter activity
CU052_RS25090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU052_RS25095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU052_RS25100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CU052_RS25115	COG0671	phosphoesterase, PA-phosphatase related
CU052_RS25120	COG0243	molybdopterin cofactor binding
CU052_RS25125	COG3005	denitrification pathway
CU052_RS25155	COG0456	acetyltransferase
CU052_RS25200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU052_RS25205	COG2356	endonuclease I
CU052_RS25235	COG2199	diguanylate cyclase activity
CU052_RS25235	COG2203	Gaf domain
CU052_RS25260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU052_RS25275	COG2814	Major facilitator Superfamily
CU052_RS25295	COG4771	TonB-dependent receptor
CU052_RS25300	COG0583	DNA-binding transcription factor activity
CU052_RS25305	COG4607	ABC-type enterochelin transport system periplasmic component
CU052_RS25310	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU052_RS25315	COG4605	iron ion homeostasis
CU052_RS25320	COG4604	ABC transporter, ATP-binding protein
CU052_RS25345	COG0739	heme binding
CU052_RS25370	COG0612	Peptidase, M16
CU052_RS25375	COG0840	transmembrane signaling receptor activity
CU052_RS25390	COG1764	response to oxidative stress
CU052_RS25395	COG1846	Transcriptional regulator
CU052_RS25410	COG3634	alkyl hydroperoxide reductase activity
CU052_RS25445	COG0583	DNA-binding transcription factor activity
CU052_RS25450	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CU052_RS25465	COG0583	DNA-binding transcription factor activity
CU052_RS25515	COG0346	lactoylglutathione lyase activity
CU052_RS25535	COG1522	sequence-specific DNA binding
CU052_RS25550	COG2258	MOSC domain
CU052_RS25555	COG2153	protein acetylation
CU052_RS25565	COG3713	MltA-interacting MipA family protein
CU052_RS25570	COG0513	Belongs to the DEAD box helicase family
CU052_RS25580	COG1595	DNA-templated transcription, initiation
CU052_RS25585	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CU052_RS25600	COG3655	Transcriptional regulator
CU052_RS25605	COG1312	Catalyzes the dehydration of D-mannonate
CU052_RS25610	COG2186	Transcriptional regulator
CU052_RS25620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CU052_RS25630	COG0246	Mannitol dehydrogenase
CU052_RS25635	COG1904	glucuronate isomerase
CU052_RS25640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU052_RS25645	COG0800	Aldolase
CU052_RS25660	COG0549	Belongs to the carbamate kinase family
CU052_RS25665	COG0531	amino acid
CU052_RS25670	COG2957	Belongs to the agmatine deiminase family
CU052_RS25695	COG2149	membrane
CU052_RS25700	COG3119	arylsulfatase activity
CU052_RS25715	COG0800	Aldolase
CU052_RS25720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU052_RS25725	COG1028	Short-chain dehydrogenase reductase Sdr
CU052_RS25730	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CU052_RS25740	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CU052_RS25745	COG4580	involved in the transport of maltose and maltodextrins
CU052_RS25750	COG0641	radical SAM
CU052_RS25760	COG0516	GMP reductase activity
CU052_RS25760	COG0517	IMP dehydrogenase activity
CU052_RS25775	COG1132	(ABC) transporter
CU052_RS25835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU052_RS25910	COG4166	transmembrane transport
CU052_RS25940	COG1595	DNA-templated transcription, initiation
CU052_RS25980	COG0848	biopolymer transport protein
CU052_RS25985	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CU052_RS25990	COG1444	tRNA N-acetyltransferase activity
CU052_RS26015	COG4608	Belongs to the ABC transporter superfamily
CU052_RS26020	COG0444	Belongs to the ABC transporter superfamily
CU052_RS26030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU052_RS26030	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
CU052_RS26055	COG0772	Belongs to the SEDS family
CU052_RS26070	COG1566	PFAM secretion protein HlyD family protein
CU052_RS26075	COG0583	DNA-binding transcription factor activity
CU052_RS26085	COG1136	(ABC) transporter
CU052_RS26110	COG2801	Transposase and inactivated derivatives
CU052_RS26125	COG3275	phosphorelay sensor kinase activity
CU052_RS26130	COG3279	Response regulator of the LytR AlgR family
CU052_RS26140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CU052_RS26165	COG0786	glutamate:sodium symporter activity
CU052_RS26180	COG1131	(ABC) transporter
CU052_RS26185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU052_RS26190	COG0786	glutamate:sodium symporter activity
CU052_RS26220	COG0561	phosphatase activity
CU052_RS26225	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CU052_RS26230	COG3623	hexulose-6-phosphate isomerase
CU052_RS26270	COG2259	Doxx family
CU052_RS26280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CU052_RS26285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CU052_RS26315	COG0577	efflux transmembrane transporter activity
CU052_RS26320	COG1136	(ABC) transporter
CU052_RS26330	COG1349	DNA-binding transcription factor activity
CU052_RS26335	COG1349	DNA-binding transcription factor activity
CU052_RS26345	COG2222	sugar isomerase
CU052_RS26350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS26360	COG3716	PTS system mannose fructose sorbose family IID component
CU052_RS26365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU052_RS26385	COG0826	peptidase U32
CU052_RS26395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU052_RS26460	COG5001	Diguanylate cyclase
CU052_RS26465	COG4580	involved in the transport of maltose and maltodextrins
CU052_RS26470	COG1609	Transcriptional regulator
CU052_RS26485	COG0395	ABC-type sugar transport system, permease component
CU052_RS26490	COG2723	6-phospho-beta-galactosidase activity
CU052_RS26495	COG3842	ATPase activity
CU052_RS26500	COG1609	Transcriptional regulator
CU052_RS26505	COG0534	Mate efflux family protein
CU052_RS26510	COG0564	pseudouridine synthase activity
CU052_RS26515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CU052_RS26525	COG0561	phosphatase activity
CU052_RS26535	COG2199	diguanylate cyclase activity
CU052_RS26545	COG3152	Membrane
CU052_RS26560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CU052_RS26575	COG0583	DNA-binding transcription factor activity
CU052_RS26610	COG2076	Multidrug Resistance protein
CU052_RS26635	COG1357	PFAM Pentapeptide repeats (8 copies)
CU052_RS26640	COG3047	cAMP biosynthetic process
CU052_RS26645	COG2358	TRAP transporter, solute receptor (TAXI family
CU052_RS26660	COG2814	Major facilitator Superfamily
CU052_RS26720	COG4771	TonB-dependent receptor
CU052_RS26725	COG1132	(ABC) transporter
CU052_RS26730	COG1132	(ABC) transporter
CU052_RS26865	COG1228	amidohydrolase
CU052_RS26875	COG3835	regulator
CU052_RS26880	COG1929	Belongs to the glycerate kinase type-1 family
CU052_RS26900	COG1982	Orn Lys Arg decarboxylase major
CU052_RS26905	COG0531	amino acid
CU052_RS26935	COG0183	Belongs to the thiolase family
CU052_RS26950	COG0583	DNA-binding transcription factor activity
CU052_RS26955	COG0477	Major facilitator Superfamily
CU052_RS26955	COG2814	Major facilitator Superfamily
CU052_RS26965	COG3962	Belongs to the TPP enzyme family
CU052_RS26970	COG0673	inositol 2-dehydrogenase activity
CU052_RS26975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU052_RS27000	COG0673	inositol 2-dehydrogenase activity
CU052_RS27005	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CU052_RS27010	COG1162	GTPase activity
CU052_RS27015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU052_RS27015	COG1263	PTS System
CU052_RS27025	COG1999	signal sequence binding
CU052_RS27050	COG0058	SHG alpha-glucan phosphorylase activity
CU052_RS27060	COG1640	4-alpha-glucanotransferase
CU052_RS27065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CU052_RS27070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU052_RS27075	COG0366	Alpha amylase catalytic
CU052_RS27090	COG3366	ferrous iron transmembrane transporter activity
CU052_RS27095	COG0700	Nucleoside recognition
CU052_RS27100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU052_RS27105	COG3339	Conserved Protein
CU052_RS27120	COG1301	dicarboxylic acid transport
CU052_RS27155	COG0583	DNA-binding transcription factor activity
CU052_RS27180	COG1596	polysaccharide export
CU052_RS27190	COG2095	MarC family integral membrane protein
CU052_RS27195	COG1349	DNA-binding transcription factor activity
CU052_RS27200	COG0738	Major facilitator superfamily
CU052_RS27205	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
CU052_RS27210	COG1070	Carbohydrate kinase
CU052_RS27215	COG4154	Belongs to the RbsD FucU family
CU052_RS27220	COG0235	Class ii aldolase
CU052_RS27225	COG1454	alcohol dehydrogenase
CU052_RS27250	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CU052_RS27255	COG2801	Transposase and inactivated derivatives
CU052_RS27260	COG0415	Belongs to the DNA photolyase family
CU052_RS27275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU052_RS27280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU052_RS27300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CU052_RS27315	COG1686	Belongs to the peptidase S11 family
CU052_RS27340	COG0583	DNA-binding transcription factor activity
CU052_RS27345	COG4628	conserved protein (DUF2132)
CU052_RS27355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU052_RS27370	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CU052_RS27375	COG0628	permease
CU052_RS27415	COG2988	succinylglutamate desuccinylase activity
CU052_RS27435	COG2814	Major facilitator Superfamily
CU052_RS27445	COG0454	-acetyltransferase
CU052_RS27455	COG0745	RESPONSE REGULATOR receiver
CU052_RS27460	COG2205	protein histidine kinase activity
CU052_RS27475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CU052_RS27515	COG1271	oxidase subunit
CU052_RS27530	COG3220	belongs to the UPF0276 family
CU052_RS27545	COG0384	phenazine biosynthesis protein PhzF
CU052_RS27550	COG0346	lactoylglutathione lyase activity
CU052_RS27565	COG0488	(ABC) transporter
CU052_RS27570	COG4628	conserved protein (DUF2132)
CU052_RS27575	COG0583	DNA-binding transcription factor activity
CU052_RS27580	COG0431	NADPH-dependent FMN reductase
CU052_RS27585	COG0435	Glutathione S-transferase
CU052_RS27590	COG0488	(ABC) transporter
CU052_RS27605	COG0583	DNA-binding transcription factor activity
CU052_RS27610	COG3226	Transcriptional regulator
CU052_RS27625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU052_RS27630	COG1280	lysine exporter protein (LysE YggA)
CU052_RS27675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CU052_RS27710	COG0640	Transcriptional regulator
CU052_RS27760	COG4974	Belongs to the 'phage' integrase family
CU052_RS27765	COG0517	IMP dehydrogenase activity
CU052_RS27790	COG2003	Belongs to the UPF0758 family
CU052_RS27845	COG3423	Transcriptional regulator
CU052_RS28030	COG3209	COG3209 Rhs family protein
CU052_RS28105	COG1357	PFAM Pentapeptide repeats (8 copies)
CU052_RS28150	COG1192	Involved in chromosome partitioning
CU052_RS28255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU052_RS28340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CU052_RS28355	COG0681	Belongs to the peptidase S26 family
CU052_RS28405	COG0714	Associated with various cellular activities
CU052_RS28465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU052_RS28555	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CU052_RS28720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU052_RS28780	COG2801	Transposase and inactivated derivatives
CU052_RS28795	COG3692	DNA binding
CU052_RS28890	COG2003	Belongs to the UPF0758 family
CU052_RS28895	COG1475	DNA binding