locus-tag	class	description
LA59_RS00030	COG1982	Orn Lys Arg decarboxylase major
LA59_RS00035	COG0531	amino acid
LA59_RS00045	COG3710	Transcriptional regulator
LA59_RS00050	COG0789	Transcriptional regulator
LA59_RS00065	COG0151	Belongs to the GarS family
LA59_RS00080	COG1253	flavin adenine dinucleotide binding
LA59_RS00085	COG3068	Protein conserved in bacteria
LA59_RS00095	COG1573	uracil-dna glycosylase
LA59_RS00115	COG2816	NAD+ diphosphatase activity
LA59_RS00120	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LA59_RS00140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LA59_RS00155	COG0250	Participates in transcription elongation, termination and antitermination
LA59_RS00160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LA59_RS00200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LA59_RS00210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA59_RS00315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA59_RS00320	COG0534	Mate efflux family protein
LA59_RS00335	COG2937	Belongs to the GPAT DAPAT family
LA59_RS00345	COG3161	chorismate lyase activity
LA59_RS00350	COG1580	Controls the rotational direction of flagella during chemotaxis
LA59_RS00355	COG0705	Rhomboid family
LA59_RS00370	COG2177	Part of the ABC transporter FtsEX involved in
LA59_RS00375	COG2884	Cell division ATP-binding protein ftsE
LA59_RS00380	COG0552	protein localization to endoplasmic reticulum
LA59_RS00385	COG0742	ribosomal rna small subunit methyltransferase
LA59_RS00395	COG2095	MarC family integral membrane protein
LA59_RS00440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA59_RS00445	COG0640	Transcriptional regulator
LA59_RS00450	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LA59_RS00455	COG1280	lysine exporter protein (LysE YggA)
LA59_RS00460	COG2267	carboxylic ester hydrolase activity
LA59_RS00480	COG3148	PFAM DTW domain containing protein
LA59_RS00485	COG3287	FIST C domain
LA59_RS00485	COG2200	EAL domain
LA59_RS00485	COG2199	diguanylate cyclase activity
LA59_RS00490	COG1011	Hydrolase
LA59_RS00510	COG0019	diaminopimelate decarboxylase activity
LA59_RS00525	COG3072	Adenylate cyclase
LA59_RS00535	COG1587	Uroporphyrinogen-III synthase
LA59_RS00540	COG2959	enzyme of heme biosynthesis
LA59_RS00545	COG3071	HemY protein
LA59_RS00585	COG0633	Ferredoxin
LA59_RS00590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LA59_RS00605	COG3118	belongs to the thioredoxin family
LA59_RS00620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LA59_RS00630	COG0514	ATP-dependent DNA helicase (RecQ)
LA59_RS00635	COG2962	Rard protein
LA59_RS00645	COG1280	lysine exporter protein (LysE YggA)
LA59_RS00650	COG0405	Gamma-glutamyltransferase
LA59_RS00655	COG0210	DNA helicase
LA59_RS00665	COG3220	belongs to the UPF0276 family
LA59_RS00685	COG2814	Major facilitator Superfamily
LA59_RS00695	COG0006	proline dipeptidase activity
LA59_RS00695	COG0006	proline dipeptidase activity
LA59_RS00710	COG2104	thiamine diphosphate biosynthetic process
LA59_RS00715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA59_RS00735	COG2132	Multicopper oxidase
LA59_RS00775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LA59_RS00785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LA59_RS00800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LA59_RS00805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LA59_RS00810	COG0551	DNA topoisomerase type I activity
LA59_RS00820	COG0758	DNA mediated transformation
LA59_RS00840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA59_RS00840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA59_RS00845	COG0569	domain protein
LA59_RS00850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA59_RS00860	COG1272	protein, Hemolysin III
LA59_RS00865	COG4326	sporulation control protein
LA59_RS00870	COG3084	Protein conserved in bacteria
LA59_RS00880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LA59_RS00885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA59_RS00890	COG0204	Acyl-transferase
LA59_RS00900	COG3706	GGDEF domain
LA59_RS00905	COG0606	chelatase, subunit chli
LA59_RS00915	COG3978	acetolactate synthase activity
LA59_RS00920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LA59_RS00925	COG0129	dihydroxy-acid dehydratase activity
LA59_RS00935	COG0583	DNA-binding transcription factor activity
LA59_RS00940	COG2814	Major facilitator Superfamily
LA59_RS00950	COG0765	amino acid transport
LA59_RS00960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LA59_RS00970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LA59_RS00995	COG0356	it plays a direct role in the translocation of protons across the membrane
LA59_RS01000	COG3312	ion transport
LA59_RS01005	COG1475	DNA binding
LA59_RS01010	COG1192	Involved in chromosome partitioning
LA59_RS01020	COG0445	tRNA wobble uridine modification
LA59_RS01025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA59_RS01050	COG1126	abc transporter atp-binding protein
LA59_RS01070	COG0592	DNA-directed DNA polymerase activity
LA59_RS01080	COG0187	DNA topoisomerase II activity
LA59_RS01085	COG0071	Belongs to the small heat shock protein (HSP20) family
LA59_RS01090	COG3977	Valine--pyruvate aminotransferase
LA59_RS01095	COG0366	Alpha amylase catalytic
LA59_RS01110	COG2119	membrane
LA59_RS01120	COG0425	Belongs to the sulfur carrier protein TusA family
LA59_RS01135	COG0604	alcohol dehydrogenase
LA59_RS01140	COG0183	Belongs to the thiolase family
LA59_RS01150	COG1739	Uncharacterized protein family UPF0029
LA59_RS01155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA59_RS01205	COG0583	DNA-binding transcription factor activity
LA59_RS01210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LA59_RS01215	COG2960	long-chain fatty acid transporting porin activity
LA59_RS01220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_RS01225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_RS01230	COG1309	transcriptional regulator
LA59_RS01270	COG0546	phosphoglycolate phosphatase activity
LA59_RS01280	COG4172	Belongs to the ABC transporter superfamily
LA59_RS01285	COG0747	negative chemotaxis
LA59_RS01290	COG0601	transmembrane transport
LA59_RS01295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_RS01330	COG1609	Transcriptional regulator
LA59_RS01335	COG0583	DNA-binding transcription factor activity
LA59_RS01340	COG2076	Multidrug Resistance protein
LA59_RS01355	COG0129	dihydroxy-acid dehydratase activity
LA59_RS01360	COG3265	gluconokinase activity
LA59_RS01365	COG2610	gluconate transmembrane transporter activity
LA59_RS01370	COG0800	Aldolase
LA59_RS01375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA59_RS01385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LA59_RS01395	COG1522	sequence-specific DNA binding
LA59_RS01400	COG5001	Diguanylate cyclase
LA59_RS01400	COG5002	protein histidine kinase activity
LA59_RS01420	COG0589	response to stress
LA59_RS01425	COG1528	Iron-storage protein
LA59_RS01435	COG2081	HI0933 family
LA59_RS01455	COG1322	Protein conserved in bacteria
LA59_RS01465	COG3165	ubiquinone biosynthetic process from chorismate
LA59_RS01480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LA59_RS01485	COG0805	protein transport
LA59_RS01490	COG0084	hydrolase, TatD family'
LA59_RS01505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA59_RS01505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA59_RS01510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LA59_RS01540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LA59_RS01550	COG2204	response regulator
LA59_RS01555	COG3852	Histidine kinase
LA59_RS01565	COG0174	glutamine synthetase
LA59_RS01570	COG1217	gtp-binding protein TYPA
LA59_RS01590	COG1490	D-aminoacyl-tRNA deacylase activity
LA59_RS01595	COG0456	acetyltransferase
LA59_RS01615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LA59_RS01620	COG3031	protein transport across the cell outer membrane
LA59_RS01630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA59_RS01635	COG1459	type II secretion system
LA59_RS01640	COG2165	general secretion pathway protein
LA59_RS01645	COG2165	general secretion pathway protein
LA59_RS01650	COG2165	general secretion pathway protein
LA59_RS01655	COG4795	General secretion pathway protein
LA59_RS01660	COG3156	type II secretion system protein K
LA59_RS01665	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LA59_RS01670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LA59_RS01680	COG1218	3'(2'),5'-bisphosphate nucleotidase
LA59_RS01685	COG0494	nUDIX hydrolase
LA59_RS01695	COG1040	competence protein
LA59_RS01710	COG2183	response to ionizing radiation
LA59_RS01720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA59_RS01735	COG2233	PERMEase
LA59_RS01745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LA59_RS01750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA59_RS01755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA59_RS01760	COG1758	RNA polymerase activity
LA59_RS01765	COG0194	GDP metabolic process
LA59_RS01780	COG0848	biopolymer transport protein
LA59_RS01785	COG0811	peptide transport
LA59_RS01805	COG4174	ABC transporter (Permease)
LA59_RS01810	COG4239	(ABC) transporter, permease
LA59_RS01815	COG0747	negative chemotaxis
LA59_RS01820	COG0444	Belongs to the ABC transporter superfamily
LA59_RS01825	COG4608	Belongs to the ABC transporter superfamily
LA59_RS01850	COG0745	RESPONSE REGULATOR receiver
LA59_RS01855	COG1561	YicC-like family, N-terminal region
LA59_RS01860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LA59_RS01865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LA59_RS01870	COG1560	Kdo2-lipid A biosynthetic process
LA59_RS01880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LA59_RS01885	COG0840	transmembrane signaling receptor activity
LA59_RS01905	COG2194	sulfuric ester hydrolase activity
LA59_RS01920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LA59_RS01935	COG0463	Glycosyl transferase, family 2
LA59_RS01940	COG0859	PFAM glycosyl transferase family 9
LA59_RS01945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LA59_RS01950	COG3642	lipopolysaccharide core region biosynthetic process
LA59_RS01965	COG0788	formyltetrahydrofolate deformylase activity
LA59_RS01975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA59_RS01990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA59_RS01995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LA59_RS02000	COG2089	acid synthase
LA59_RS02010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LA59_RS02025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LA59_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_RS02050	COG1519	Transferase
LA59_RS02055	COG0859	PFAM glycosyl transferase family 9
LA59_RS02060	COG1560	Kdo2-lipid A biosynthetic process
LA59_RS02070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA59_RS02115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LA59_RS02130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA59_RS02140	COG0463	Glycosyl transferase, family 2
LA59_RS02155	COG0438	transferase activity, transferring glycosyl groups
LA59_RS02165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LA59_RS02170	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LA59_RS02175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LA59_RS02175	COG0517	IMP dehydrogenase activity
LA59_RS02180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LA59_RS02200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LA59_RS02205	COG0149	triose-phosphate isomerase activity
LA59_RS02230	COG1494	fructose-1,6-bisphosphatase
LA59_RS02240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA59_RS02245	COG1575	Belongs to the MenA family. Type 1 subfamily
LA59_RS02265	COG1609	Transcriptional regulator
LA59_RS02270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LA59_RS02275	COG0254	rRNA binding
LA59_RS02290	COG0088	Forms part of the polypeptide exit tunnel
LA59_RS02310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LA59_RS02360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LA59_RS02375	COG1841	ribosomal large subunit assembly
LA59_RS02380	COG0200	Binds to the 23S rRNA
LA59_RS02385	COG0201	protein transport
LA59_RS02390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LA59_RS02395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LA59_RS02400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LA59_RS02410	COG0202	RNA polymerase activity
LA59_RS02415	COG0203	ribosomal protein L17
LA59_RS02425	COG0545	Peptidyl-prolyl cis-trans isomerase
LA59_RS02440	COG2153	protein acetylation
LA59_RS02445	COG0513	Belongs to the DEAD box helicase family
LA59_RS02455	COG0737	Belongs to the 5'-nucleotidase family
LA59_RS02460	COG1648	precorrin-2 dehydrogenase activity
LA59_RS02460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LA59_RS02475	COG0471	metal ion transport
LA59_RS02475	COG3273	potassium ion transport
LA59_RS02480	COG0529	Catalyzes the synthesis of activated sulfate
LA59_RS02500	COG1136	(ABC) transporter
LA59_RS02510	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LA59_RS02520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA59_RS02525	COG0729	surface antigen
LA59_RS02535	COG2105	PFAM AIG2 family protein
LA59_RS02545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LA59_RS02555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA59_RS02560	COG0163	prenyltransferase activity
LA59_RS02565	COG4143	(ABC) transporter
LA59_RS02570	COG1178	ABC-type Fe3 transport system permease component
LA59_RS02575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LA59_RS02610	COG3385	transposase activity
LA59_RS02615	COG0142	geranyltranstransferase activity
LA59_RS02620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LA59_RS02630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LA59_RS02635	COG2966	Psort location CytoplasmicMembrane, score
LA59_RS02640	COG3610	response to peptide
LA59_RS02660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LA59_RS02665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LA59_RS02670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA59_RS02675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LA59_RS02680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LA59_RS02700	COG0473	3-isopropylmalate dehydrogenase activity
LA59_RS02705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LA59_RS02715	COG0671	phosphoesterase, PA-phosphatase related
LA59_RS02725	COG0583	DNA-binding transcription factor activity
LA59_RS02730	COG1022	Amp-dependent synthetase and ligase
LA59_RS02735	COG0028	Belongs to the TPP enzyme family
LA59_RS02740	COG0440	acetolactate synthase activity
LA59_RS02745	COG3706	GGDEF domain
LA59_RS02755	COG0469	pyruvate kinase activity
LA59_RS02760	COG1349	DNA-binding transcription factor activity
LA59_RS02765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LA59_RS02785	COG5002	protein histidine kinase activity
LA59_RS02790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA59_RS02795	COG3722	fumarate hydratase activity
LA59_RS02805	COG2213	PTS system mannitol-specific
LA59_RS02805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_RS02840	COG0358	DNA primase activity
LA59_RS02845	COG1610	YqeY-like protein
LA59_RS02850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LA59_RS02855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LA59_RS02860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA59_RS02870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LA59_RS02875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LA59_RS02890	COG3267	Type II secretory pathway component ExeA
LA59_RS02890	COG3409	Peptidoglycan-binding domain 1 protein
LA59_RS02900	COG4991	sh3 domain protein
LA59_RS02905	COG0306	phosphate transporter
LA59_RS02910	COG1392	Phosphate transport regulator
LA59_RS02915	COG3025	triphosphatase activity
LA59_RS02920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LA59_RS02930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LA59_RS02940	COG1538	Outer membrane efflux protein
LA59_RS02945	COG0494	nUDIX hydrolase
LA59_RS02950	COG3151	Protein conserved in bacteria
LA59_RS02960	COG3150	esterase
LA59_RS02970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LA59_RS02975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA59_RS02990	COG3105	Protein conserved in bacteria
LA59_RS02995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LA59_RS03010	COG0723	plastoquinol--plastocyanin reductase activity
LA59_RS03015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LA59_RS03020	COG2857	Cytochrome c1
LA59_RS03025	COG0625	glutathione transferase activity
LA59_RS03030	COG2969	positive regulation of protein catabolic process
LA59_RS03035	COG2823	Periplasmic or secreted lipoprotein
LA59_RS03040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LA59_RS03055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LA59_RS03070	COG3116	cell division
LA59_RS03075	COG0768	penicillin binding
LA59_RS03080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LA59_RS03085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA59_RS03100	COG0772	Belongs to the SEDS family
LA59_RS03115	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LA59_RS03120	COG0849	cell division
LA59_RS03125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LA59_RS03140	COG0494	nUDIX hydrolase
LA59_RS03150	COG0505	Belongs to the CarA family
LA59_RS03155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LA59_RS03175	COG0730	response to heat
LA59_RS03180	COG0583	DNA-binding transcription factor activity
LA59_RS03185	COG2860	membrane
LA59_RS03210	COG0493	'glutamate synthase
LA59_RS03215	COG0069	glutamate synthase activity
LA59_RS03215	COG0070	glutamate synthase
LA59_RS03215	COG0067	glutamate synthase
LA59_RS03225	COG0067	glutamate synthase
LA59_RS03225	COG0069	glutamate synthase activity
LA59_RS03225	COG0070	glutamate synthase
LA59_RS03230	COG1242	4 iron, 4 sulfur cluster binding
LA59_RS03235	COG5001	Diguanylate cyclase
LA59_RS03235	COG2203	Gaf domain
LA59_RS03235	COG4251	negative regulation of phosphorylation
LA59_RS03235	COG3706	GGDEF domain
LA59_RS03245	COG0784	Response regulator, receiver
LA59_RS03245	COG2198	Histidine kinase
LA59_RS03245	COG5002	protein histidine kinase activity
LA59_RS03255	COG0745	RESPONSE REGULATOR receiver
LA59_RS03265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA59_RS03280	COG0083	homoserine kinase activity
LA59_RS03285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LA59_RS03290	COG0431	NADPH-dependent FMN reductase
LA59_RS03320	COG1115	amino acid carrier protein
LA59_RS03325	COG3022	response to hydroperoxide
LA59_RS03335	COG0513	Belongs to the DEAD box helicase family
LA59_RS03350	COG0716	FMN binding
LA59_RS03355	COG4974	Belongs to the 'phage' integrase family
LA59_RS03360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA59_RS03365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LA59_RS03370	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LA59_RS03385	COG3385	transposase activity
LA59_RS03395	COG0667	Aldo Keto reductase
LA59_RS03415	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
LA59_RS03420	COG0730	response to heat
LA59_RS03435	COG1283	sodium-dependent phosphate transmembrane transporter activity
LA59_RS03440	COG0583	DNA-binding transcription factor activity
LA59_RS03445	COG0640	Transcriptional regulator
LA59_RS03450	COG0268	Binds directly to 16S ribosomal RNA
LA59_RS03455	COG0728	peptidoglycan biosynthetic process
LA59_RS03460	COG0196	riboflavin kinase activity
LA59_RS03475	COG1047	Peptidyl-prolyl cis-trans
LA59_RS03480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LA59_RS03485	COG3279	Response regulator of the LytR AlgR family
LA59_RS03490	COG3275	phosphorelay sensor kinase activity
LA59_RS03495	COG1966	Carbon starvation protein
LA59_RS03510	COG3385	transposase activity
LA59_RS03520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LA59_RS03530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA59_RS03535	COG0287	Prephenate dehydrogenase
LA59_RS03535	COG1605	Chorismate mutase
LA59_RS03540	COG0739	heme binding
LA59_RS03550	COG0488	(ABC) transporter
LA59_RS03565	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LA59_RS03570	COG0077	Prephenate dehydratase
LA59_RS03570	COG1605	Chorismate mutase
LA59_RS03575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LA59_RS03580	COG0741	lytic transglycosylase activity
LA59_RS03585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA59_RS03590	COG0564	pseudouridine synthase activity
LA59_RS03595	COG1496	oxidoreductase activity
LA59_RS03600	COG0542	response to heat
LA59_RS03655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA59_RS03660	COG0826	peptidase U32
LA59_RS03670	COG0745	RESPONSE REGULATOR receiver
LA59_RS03675	COG5002	protein histidine kinase activity
LA59_RS03685	COG0248	Ppx GppA phosphatase
LA59_RS03690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LA59_RS03695	COG0573	inorganic phosphate transmembrane transporter activity
LA59_RS03700	COG0581	inorganic phosphate transmembrane transporter activity
LA59_RS03705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LA59_RS03710	COG0704	Plays a role in the regulation of phosphate uptake
LA59_RS03740	COG0450	alkyl hydroperoxide reductase
LA59_RS03745	COG0583	DNA-binding transcription factor activity
LA59_RS03750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LA59_RS03760	COG0517	IMP dehydrogenase activity
LA59_RS03785	COG1862	Preprotein translocase
LA59_RS03790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_RS03795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_RS03810	COG0483	inositol monophosphate 1-phosphatase activity
LA59_RS03815	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LA59_RS03830	COG0822	iron-sulfur transferase activity
LA59_RS03835	COG0316	Belongs to the HesB IscA family
LA59_RS03850	COG0633	Ferredoxin
LA59_RS03855	COG2975	iron-sulfur cluster assembly
LA59_RS03890	COG2976	Protein conserved in bacteria
LA59_RS03895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA59_RS03910	COG2203	Gaf domain
LA59_RS03910	COG2199	diguanylate cyclase activity
LA59_RS03920	COG0516	GMP reductase activity
LA59_RS03920	COG0517	IMP dehydrogenase activity
LA59_RS03930	COG1757	Na H antiporter
LA59_RS03940	COG1584	GPR1 FUN34 yaaH family protein
LA59_RS03945	COG1115	amino acid carrier protein
LA59_RS03955	COG0583	DNA-binding transcription factor activity
LA59_RS03970	COG2873	o-acetylhomoserine
LA59_RS03980	COG0316	Belongs to the HesB IscA family
LA59_RS03985	COG0719	Fe-S assembly protein
LA59_RS03990	COG0396	ATPase activity
LA59_RS03995	COG0719	Fe-S assembly protein
LA59_RS04015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LA59_RS04035	COG1289	transmembrane transporter activity
LA59_RS04040	COG0583	DNA-binding transcription factor activity
LA59_RS04070	COG0582	viral genome integration into host DNA
LA59_RS04085	COG2867	negative regulation of translational initiation
LA59_RS04090	COG2914	Belongs to the UPF0125 (RnfH) family
LA59_RS04095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA59_RS04100	COG0497	DNA recombination
LA59_RS04120	COG1301	dicarboxylic acid transport
LA59_RS04140	COG4969	Belongs to the N-Me-Phe pilin family
LA59_RS04160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LA59_RS04165	COG0590	tRNA wobble adenosine to inosine editing
LA59_RS04175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LA59_RS04175	COG0047	phosphoribosylformylglycinamidine synthase activity
LA59_RS04205	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA59_RS04210	COG2252	PERMEase
LA59_RS04215	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LA59_RS04220	COG1073	alpha beta
LA59_RS04235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LA59_RS04240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LA59_RS04245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA59_RS04245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA59_RS04270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LA59_RS04275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LA59_RS04285	COG0142	geranyltranstransferase activity
LA59_RS04295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LA59_RS04310	COG0583	DNA-binding transcription factor activity
LA59_RS04320	COG2363	Small membrane protein
LA59_RS04340	COG1611	Belongs to the LOG family
LA59_RS04365	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LA59_RS04370	COG0737	Belongs to the 5'-nucleotidase family
LA59_RS04380	COG1464	Belongs to the NlpA lipoprotein family
LA59_RS04385	COG2011	ABC-type metal ion transport system permease component
LA59_RS04390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LA59_RS04395	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LA59_RS04405	COG1263	PTS System
LA59_RS04405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_RS04410	COG0366	Alpha amylase catalytic
LA59_RS04425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LA59_RS04430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LA59_RS04450	COG1686	Belongs to the peptidase S11 family
LA59_RS04455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LA59_RS04460	COG0772	Belongs to the SEDS family
LA59_RS04465	COG0768	penicillin binding
LA59_RS04475	COG0799	negative regulation of ribosome biogenesis
LA59_RS04480	COG1466	dna polymerase III delta subunit
LA59_RS04485	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LA59_RS04495	COG2888	peptidyl-tyrosine sulfation
LA59_RS04500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LA59_RS04505	COG4535	Mg2 and Co2 transporter CorC
LA59_RS04515	COG1702	phosphate starvation-inducible protein PhoH
LA59_RS04525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA59_RS04645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LA59_RS04670	COG2890	protein-(glutamine-N5) methyltransferase activity
LA59_RS04675	COG3094	Invasion gene expression up-regulator, SirB
LA59_RS04680	COG2912	Transglutaminase-like superfamily
LA59_RS04685	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LA59_RS04690	COG0737	Belongs to the 5'-nucleotidase family
LA59_RS04695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LA59_RS04700	COG1187	pseudouridine synthase activity
LA59_RS04705	COG2840	Smr protein MutS2
LA59_RS04750	COG2217	Heavy metal translocating P-type atpase
LA59_RS04750	COG2608	mercury ion transmembrane transporter activity
LA59_RS04760	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LA59_RS04815	COG0784	Response regulator, receiver
LA59_RS04815	COG0835	chemotaxis
LA59_RS04820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LA59_RS04825	COG1815	bacterial-type flagellum-dependent cell motility
LA59_RS04830	COG1558	bacterial-type flagellum-dependent cell motility
LA59_RS04845	COG4787	bacterial-type flagellum-dependent cell motility
LA59_RS04855	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LA59_RS04860	COG1706	bacterial-type flagellum-dependent cell motility
LA59_RS04865	COG3951	Flagellar rod assembly protein muramidase FlgJ
LA59_RS04865	COG1705	Flagellar rod assembly protein muramidase FlgJ
LA59_RS04880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_RS04885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_RS04890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_RS04895	COG2190	(PTS) system
LA59_RS04900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA59_RS04905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_RS04910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LA59_RS04915	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LA59_RS04945	COG0330	HflC and HflK could
LA59_RS04950	COG3118	belongs to the thioredoxin family
LA59_RS04955	COG0300	oxidoreductase activity
LA59_RS04960	COG1090	epimerase
LA59_RS04990	COG0622	Phosphoesterase
LA59_RS05010	COG3710	Transcriptional regulator
LA59_RS05025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LA59_RS05030	COG3104	oligopeptide transport
LA59_RS05040	COG0367	asparagine synthase
LA59_RS05045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LA59_RS05045	COG4651	solute:proton antiporter activity
LA59_RS05050	COG1846	Transcriptional regulator
LA59_RS05050	COG1940	carbohydrate kinase activity
LA59_RS05055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LA59_RS05060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_RS05060	COG2190	(PTS) system
LA59_RS05060	COG1263	PTS System
LA59_RS05070	COG2165	general secretion pathway protein
LA59_RS05075	COG0735	belongs to the Fur family
LA59_RS05085	COG0716	FMN binding
LA59_RS05095	COG0596	Alpha beta hydrolase
LA59_RS05100	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LA59_RS05105	COG0033	Phosphoglucomutase
LA59_RS05120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LA59_RS05135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LA59_RS05140	COG1053	succinate dehydrogenase
LA59_RS05150	COG0567	Dehydrogenase, E1 component
LA59_RS05155	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA59_RS05170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA59_RS05175	COG1121	(ABC) transporter
LA59_RS05180	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LA59_RS05185	COG4977	sequence-specific DNA binding
LA59_RS05190	COG1918	ferrous iron import across plasma membrane
LA59_RS05220	COG3102	Protein conserved in bacteria
LA59_RS05225	COG0788	formyltetrahydrofolate deformylase activity
LA59_RS05230	COG1199	ATP-dependent helicase activity
LA59_RS05235	COG1214	PFAM Peptidase M22, glycoprotease
LA59_RS05245	COG3065	identical protein binding
LA59_RS05250	COG2267	carboxylic ester hydrolase activity
LA59_RS05255	COG0318	PFAM AMP-dependent synthetase and ligase
LA59_RS05260	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LA59_RS05265	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LA59_RS05270	COG2894	cell division
LA59_RS05285	COG2951	lytic endotransglycosylase activity
LA59_RS05295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA59_RS05330	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_RS05365	COG2986	histidine ammonia-lyase
LA59_RS05370	COG1216	Glycosyl transferase, family 2
LA59_RS05390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA59_RS05395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA59_RS05425	COG2226	methyltransferase
LA59_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_RS05450	COG1169	isochorismate synthase
LA59_RS05455	COG1021	2,3-dihydroxybenzoate-AMP ligase
LA59_RS05460	COG3433	isochorismatase activity
LA59_RS05460	COG1535	isochorismatase
LA59_RS05465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LA59_RS05465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LA59_RS05480	COG4771	TonB-dependent receptor
LA59_RS05485	COG1253	flavin adenine dinucleotide binding
LA59_RS05490	COG0513	Belongs to the DEAD box helicase family
LA59_RS05495	COG0569	domain protein
LA59_RS05500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA59_RS05515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LA59_RS05520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LA59_RS05525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LA59_RS05540	COG4191	Histidine kinase
LA59_RS05560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LA59_RS05565	COG0776	regulation of translation
LA59_RS05570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA59_RS05595	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LA59_RS05675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LA59_RS05680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LA59_RS05685	COG0436	Aminotransferase
LA59_RS05690	COG1169	isochorismate synthase
LA59_RS05700	COG0596	Alpha beta hydrolase
LA59_RS05705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LA59_RS05720	COG1263	PTS System
LA59_RS05720	COG2190	(PTS) system
LA59_RS05720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_RS05725	COG0583	DNA-binding transcription factor activity
LA59_RS05735	COG2855	membrane
LA59_RS05790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_RS05815	COG1522	sequence-specific DNA binding
LA59_RS05825	COG1946	Acyl-CoA thioesterase
LA59_RS05830	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LA59_RS05855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LA59_RS05860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA59_RS05865	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LA59_RS05870	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LA59_RS05875	COG0617	tRNA 3'-terminal CCA addition
LA59_RS05875	COG0517	IMP dehydrogenase activity
LA59_RS05875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LA59_RS05885	COG2217	Heavy metal translocating P-type atpase
LA59_RS05905	COG0537	adenosine 5'-monophosphoramidase activity
LA59_RS05935	COG1252	NADH dehydrogenase
LA59_RS05950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LA59_RS05960	COG4591	ABC-type transport system involved in lipoprotein release permease component
LA59_RS05965	COG1136	(ABC) transporter
LA59_RS05970	COG4591	ABC-type transport system involved in lipoprotein release permease component
LA59_RS05985	COG1132	(ABC) transporter
LA59_RS06005	COG2719	SpoVR family
LA59_RS06010	COG2718	Belongs to the UPF0229 family
LA59_RS06015	COG2766	serine protein kinase
LA59_RS06030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA59_RS06040	COG1882	Formate acetyltransferase
LA59_RS06075	COG0708	Exodeoxyribonuclease III
LA59_RS06080	COG0840	transmembrane signaling receptor activity
LA59_RS06095	COG0730	response to heat
LA59_RS06100	COG1199	ATP-dependent helicase activity
LA59_RS06110	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LA59_RS06115	COG1187	pseudouridine synthase activity
LA59_RS06125	COG1278	Cold shock
LA59_RS06135	COG0542	response to heat
LA59_RS06140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LA59_RS06170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA59_RS06175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LA59_RS06180	COG0297	glycogen (starch) synthase activity
LA59_RS06200	COG3070	regulator of competence-specific genes
LA59_RS06215	COG0745	RESPONSE REGULATOR receiver
LA59_RS06220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LA59_RS06225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA59_RS06235	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LA59_RS06240	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LA59_RS06255	COG0189	ligase activity
LA59_RS06255	COG4067	protein conserved in archaea
LA59_RS06270	COG1801	Protein of unknown function DUF72
LA59_RS06285	COG0840	transmembrane signaling receptor activity
LA59_RS06290	COG0632	four-way junction helicase activity
LA59_RS06300	COG1271	oxidase subunit
LA59_RS06305	COG1294	oxidase, subunit
LA59_RS06310	COG4890	Cyd operon protein YbgT
LA59_RS06320	COG0824	Thioesterase
LA59_RS06325	COG0811	peptide transport
LA59_RS06340	COG0823	Involved in the tonB-independent uptake of proteins
LA59_RS06345	COG2885	chlorophyll binding
LA59_RS06350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LA59_RS06365	COG0673	inositol 2-dehydrogenase activity
LA59_RS06370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA59_RS06370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_RS06370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_RS06375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_RS06380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_RS06385	COG1882	Formate acetyltransferase
LA59_RS06390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA59_RS06395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA59_RS06400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LA59_RS06405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_RS06410	COG2207	Transcriptional regulator
LA59_RS06415	COG0371	Dehydrogenase
LA59_RS06420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA59_RS06440	COG3766	membrane
LA59_RS06450	COG0754	glutathionylspermidine amidase activity
LA59_RS06460	COG5002	protein histidine kinase activity
LA59_RS06460	COG0784	Response regulator, receiver
LA59_RS06540	COG4669	(LipO)protein
LA59_RS06585	COG4792	protein secretion
LA59_RS06590	COG4791	protein targeting
LA59_RS06595	COG4794	Type iii secretion
LA59_RS06600	COG4790	Type iii secretion
LA59_RS06670	COG0457	Tetratricopeptide repeat
LA59_RS06685	COG0789	Transcriptional regulator
LA59_RS06690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LA59_RS06695	COG3385	transposase activity
LA59_RS06710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_RS06710	COG1263	PTS System
LA59_RS06715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_RS06720	COG1621	beta-fructofuranosidase activity
LA59_RS06725	COG2824	Alkylphosphonate utilization operon protein PhnA
LA59_RS06765	COG0534	Mate efflux family protein
LA59_RS06770	COG0444	Belongs to the ABC transporter superfamily
LA59_RS06775	COG4608	Belongs to the ABC transporter superfamily
LA59_RS06780	COG0747	negative chemotaxis
LA59_RS06800	COG0583	DNA-binding transcription factor activity
LA59_RS06815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_RS06820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_RS06830	COG2186	Transcriptional regulator
LA59_RS06840	COG1288	antiporter activity
LA59_RS06865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_RS06880	COG2176	DNA-directed DNA polymerase activity
LA59_RS06885	COG0517	IMP dehydrogenase activity
LA59_RS06890	COG2186	Transcriptional regulator
LA59_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_RS06900	COG2186	Transcriptional regulator
LA59_RS06920	COG1917	Cupin 2, conserved barrel domain protein
LA59_RS06925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_RS06930	COG0800	Aldolase
LA59_RS06935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_RS06945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LA59_RS06975	COG3568	Endonuclease Exonuclease Phosphatase
LA59_RS06985	COG4934	collagen metabolic process
LA59_RS07020	COG0686	Belongs to the AlaDH PNT family
LA59_RS07030	COG1674	ftsk spoiiie
LA59_RS07040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA59_RS07060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LA59_RS07065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LA59_RS07100	COG0300	oxidoreductase activity
LA59_RS07115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LA59_RS07125	COG2268	Band 7 protein
LA59_RS07135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LA59_RS07145	COG0482	sulfurtransferase activity
LA59_RS07155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_RS07165	COG1757	Na H antiporter
LA59_RS07175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LA59_RS07180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LA59_RS07185	COG0131	Imidazoleglycerol-phosphate dehydratase
LA59_RS07185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LA59_RS07190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LA59_RS07195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LA59_RS07205	COG0140	phosphoribosyl-ATP diphosphatase activity
LA59_RS07205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LA59_RS07210	COG3012	SEC-C Motif Domain Protein
LA59_RS07215	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LA59_RS07220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA59_RS07225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA59_RS07230	COG0215	cysteine-tRNA ligase activity
LA59_RS07235	COG1435	thymidine kinase activity
LA59_RS07240	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LA59_RS07265	COG2116	formate transmembrane transporter activity
LA59_RS07270	COG0390	transport system, permease component
LA59_RS07275	COG4459	periplasmic nitrate reductase
LA59_RS07280	COG3005	denitrification pathway
LA59_RS07285	COG0243	molybdopterin cofactor binding
LA59_RS07300	COG1121	(ABC) transporter
LA59_RS07305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA59_RS07310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA59_RS07315	COG1227	inorganic diphosphatase activity
LA59_RS07325	COG4172	Belongs to the ABC transporter superfamily
LA59_RS07335	COG4171	peptide transport system, permease
LA59_RS07350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LA59_RS07355	COG1842	Phage shock protein A
LA59_RS07385	COG2818	Glycosylase
LA59_RS07390	COG5380	lipid catabolic process
LA59_RS07395	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LA59_RS07400	COG0626	cystathionine gamma-synthase activity
LA59_RS07410	COG0733	neurotransmitter:sodium symporter activity
LA59_RS07420	COG0564	pseudouridine synthase activity
LA59_RS07430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA59_RS07435	COG1151	hydroxylamine reductase activity
LA59_RS07440	COG3604	Transcriptional regulator
LA59_RS07445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LA59_RS07450	COG4136	ATPase activity
LA59_RS07455	COG4135	transport system, permease component
LA59_RS07460	COG4134	Bacterial extracellular solute-binding protein
LA59_RS07465	COG0398	Pfam SNARE associated Golgi protein
LA59_RS07475	COG0493	'glutamate synthase
LA59_RS07500	COG0659	secondary active sulfate transmembrane transporter activity
LA59_RS07510	COG3313	Fe-S protein
LA59_RS07565	COG1061	Type III restriction enzyme res subunit
LA59_RS07570	COG1187	pseudouridine synthase activity
LA59_RS07575	COG2814	Major facilitator Superfamily
LA59_RS07585	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_RS07595	COG1609	Transcriptional regulator
LA59_RS07600	COG0702	epimerase
LA59_RS07605	COG0534	Mate efflux family protein
LA59_RS07610	COG4181	ATPase activity
LA59_RS07640	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LA59_RS07650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LA59_RS07660	COG1737	Transcriptional regulator
LA59_RS07665	COG0076	glutamate decarboxylase activity
LA59_RS07675	COG2431	L-lysine efflux transmembrane transporter activity
LA59_RS07685	COG3070	regulator of competence-specific genes
LA59_RS07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_RS07700	COG4191	Histidine kinase
LA59_RS07710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LA59_RS07720	COG3706	GGDEF domain
LA59_RS07740	COG0583	DNA-binding transcription factor activity
LA59_RS07745	COG2610	gluconate transmembrane transporter activity
LA59_RS07755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LA59_RS07760	COG4988	ABC transporter
LA59_RS07765	COG0492	ferredoxin-NADP+ reductase activity
LA59_RS07785	COG3706	GGDEF domain
LA59_RS07790	COG0471	metal ion transport
LA59_RS07795	COG2949	membrane
LA59_RS07805	COG1643	Atp-dependent helicase
LA59_RS07845	COG0471	metal ion transport
LA59_RS07850	COG4191	Histidine kinase
LA59_RS07850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_RS07860	COG5001	Diguanylate cyclase
LA59_RS07860	COG3300	MHYT domain
LA59_RS07870	COG1280	lysine exporter protein (LysE YggA)
LA59_RS07875	COG1328	CTP reductase activity
LA59_RS07880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA59_RS07890	COG0861	Integral membrane protein TerC family
LA59_RS07900	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA59_RS07910	COG3706	GGDEF domain
LA59_RS07920	COG1454	alcohol dehydrogenase
LA59_RS07925	COG0814	amino acid
LA59_RS07940	COG1120	ATPase activity
LA59_RS07945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LA59_RS07950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA59_RS07955	COG4774	siderophore transport
LA59_RS07970	COG1132	(ABC) transporter
LA59_RS07975	COG1132	(ABC) transporter
LA59_RS07980	COG2165	general secretion pathway protein
LA59_RS07990	COG0583	DNA-binding transcription factor activity
LA59_RS08015	COG0443	Heat shock 70 kDa protein
LA59_RS08020	COG0443	Heat shock 70 kDa protein
LA59_RS08030	COG3706	GGDEF domain
LA59_RS08060	COG0243	molybdopterin cofactor binding
LA59_RS08065	COG0437	4 iron, 4 sulfur cluster binding
LA59_RS08070	COG3302	dmso reductase anchor subunit
LA59_RS08085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LA59_RS08090	COG1643	Atp-dependent helicase
LA59_RS08115	COG3063	Type IV pilus biogenesis stability protein PilW
LA59_RS08140	COG0531	amino acid
LA59_RS08145	COG1280	lysine exporter protein (LysE YggA)
LA59_RS08150	COG0583	DNA-binding transcription factor activity
LA59_RS08155	COG1560	Kdo2-lipid A biosynthetic process
LA59_RS08170	COG1846	Transcriptional regulator
LA59_RS08185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LA59_RS08290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LA59_RS08295	COG2197	response regulator
LA59_RS08330	COG1280	lysine exporter protein (LysE YggA)
LA59_RS08345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_RS08350	COG2358	TRAP transporter, solute receptor (TAXI family
LA59_RS08355	COG0730	response to heat
LA59_RS08380	COG0456	acetyltransferase
LA59_RS08390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA59_RS08500	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LA59_RS08505	COG0372	Belongs to the citrate synthase family
LA59_RS08515	COG2828	Protein conserved in bacteria
LA59_RS08540	COG0561	phosphatase activity
LA59_RS08545	COG0602	queuosine metabolic process
LA59_RS08555	COG2199	diguanylate cyclase activity
LA59_RS08555	COG2203	Gaf domain
LA59_RS08590	COG3064	Membrane
LA59_RS08600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LA59_RS08610	COG0297	glycogen (starch) synthase activity
LA59_RS08650	COG2204	response regulator
LA59_RS08680	COG1793	dna ligase
LA59_RS08690	COG0534	Mate efflux family protein
LA59_RS08695	COG0307	riboflavin synthase, alpha
LA59_RS08705	COG3001	Fructosamine kinase
LA59_RS08710	COG2201	protein-glutamate methylesterase activity
LA59_RS08715	COG3706	GGDEF domain
LA59_RS08725	COG0791	NLP P60 protein
LA59_RS08730	COG0840	transmembrane signaling receptor activity
LA59_RS08770	COG3148	PFAM DTW domain containing protein
LA59_RS08775	COG1940	carbohydrate kinase activity
LA59_RS08785	COG0303	'Molybdopterin
LA59_RS08795	COG3842	ATPase activity
LA59_RS08800	COG4662	Binding-protein-dependent transport system inner membrane component
LA59_RS08810	COG2204	response regulator
LA59_RS08815	COG4191	Histidine kinase
LA59_RS08830	COG0488	(ABC) transporter
LA59_RS08835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LA59_RS08855	COG3381	protein complex oligomerization
LA59_RS08865	COG0243	molybdopterin cofactor binding
LA59_RS08865	COG3383	formate dehydrogenase (NAD+) activity
LA59_RS08870	COG0437	4 iron, 4 sulfur cluster binding
LA59_RS08890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LA59_RS08895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LA59_RS08905	COG1177	transmembrane transport
LA59_RS08915	COG3842	ATPase activity
LA59_RS08925	COG2992	FlgJ-related protein
LA59_RS08940	COG0589	response to stress
LA59_RS08945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA59_RS08960	COG2217	Heavy metal translocating P-type atpase
LA59_RS08970	COG2010	Cytochrome c
LA59_RS08985	COG3278	Belongs to the heme-copper respiratory oxidase family
LA59_RS09000	COG0784	Response regulator, receiver
LA59_RS09000	COG2205	protein histidine kinase activity
LA59_RS09030	COG1067	ATP-dependent peptidase activity
LA59_RS09035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA59_RS09050	COG0488	(ABC) transporter
LA59_RS09075	COG2902	Dehydrogenase
LA59_RS09080	COG0308	aminopeptidase N
LA59_RS09095	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LA59_RS09100	COG1956	GAF domain-containing protein
LA59_RS09105	COG1132	(ABC) transporter
LA59_RS09110	COG2995	paraquat-inducible protein a
LA59_RS09115	COG3008	intermembrane lipid transfer
LA59_RS09140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA59_RS09155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_RS09160	COG4597	amino acid ABC transporter
LA59_RS09165	COG0765	amino acid transport
LA59_RS09170	COG1126	abc transporter atp-binding protein
LA59_RS09175	COG0670	Belongs to the BI1 family
LA59_RS09180	COG2920	part of a sulfur-relay system
LA59_RS09185	COG1254	Belongs to the acylphosphatase family
LA59_RS09215	COG5001	Diguanylate cyclase
LA59_RS09215	COG3300	MHYT domain
LA59_RS09220	COG4999	Histidine kinase
LA59_RS09220	COG3437	response regulator, receiver
LA59_RS09220	COG3850	Histidine kinase
LA59_RS09220	COG2205	protein histidine kinase activity
LA59_RS09235	COG0110	maltose O-acetyltransferase activity
LA59_RS09255	COG1846	Transcriptional regulator
LA59_RS09265	COG3247	response to pH
LA59_RS09270	COG0668	transmembrane transport
LA59_RS09285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LA59_RS09345	COG4964	Belongs to the GSP D family
LA59_RS09365	COG0393	Putative heavy-metal-binding
LA59_RS09370	COG3152	Membrane
LA59_RS09380	COG2207	Transcriptional regulator
LA59_RS09400	COG0589	response to stress
LA59_RS09405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LA59_RS09410	COG0363	glucosamine-6-phosphate deaminase activity
LA59_RS09415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LA59_RS09425	COG4774	siderophore transport
LA59_RS09430	COG4565	transcriptional regulatory protein
LA59_RS09435	COG3290	protein histidine kinase activity
LA59_RS09450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_RS09480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_RS09485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_RS09490	COG0387	Pfam Sodium calcium exchanger
LA59_RS09500	COG2239	Acts as a magnesium transporter
LA59_RS09520	COG0583	DNA-binding transcription factor activity
LA59_RS09525	COG0668	transmembrane transport
LA59_RS09545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LA59_RS09575	COG2186	Transcriptional regulator
LA59_RS09590	COG0702	epimerase
LA59_RS09595	COG0583	DNA-binding transcription factor activity
LA59_RS09600	COG1404	Belongs to the peptidase S8 family
LA59_RS09605	COG1858	cytochrome C peroxidase
LA59_RS09615	COG0527	aspartate kinase activity
LA59_RS09620	COG0662	Cupin 2, conserved barrel domain protein
LA59_RS09625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LA59_RS09630	COG0456	acetyltransferase
LA59_RS09635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA59_RS09645	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LA59_RS09650	COG0534	Mate efflux family protein
LA59_RS09665	COG1368	sulfuric ester hydrolase activity
LA59_RS09695	COG1115	amino acid carrier protein
LA59_RS09700	COG1012	belongs to the aldehyde dehydrogenase family
LA59_RS09705	COG3284	Transcriptional regulator
LA59_RS09735	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LA59_RS09745	COG3051	citrate lyase alpha subunit
LA59_RS09750	COG2301	Belongs to the HpcH HpaI aldolase family
LA59_RS09760	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LA59_RS09770	COG3630	sodium ion export across plasma membrane
LA59_RS09775	COG0511	ligase activity, forming carbon-carbon bonds
LA59_RS09775	COG5016	pyruvate
LA59_RS09780	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LA59_RS09790	COG4565	transcriptional regulatory protein
LA59_RS09830	COG1051	belongs to the nudix hydrolase family
LA59_RS09880	COG0625	glutathione transferase activity
LA59_RS09890	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LA59_RS09905	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA59_RS09915	COG0601	transmembrane transport
LA59_RS09920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_RS09925	COG0444	Belongs to the ABC transporter superfamily
LA59_RS09950	COG3291	Pkd domain containing protein
LA59_RS09965	COG0745	RESPONSE REGULATOR receiver
LA59_RS09975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_RS09980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_RS10000	COG0813	purine-nucleoside phosphorylase activity
LA59_RS10005	COG1177	transmembrane transport
LA59_RS10010	COG1176	ABC-type spermidine putrescine transport system, permease component I
LA59_RS10015	COG3842	ATPase activity
LA59_RS10035	COG2199	diguanylate cyclase activity
LA59_RS10045	COG1451	nucleotide metabolic process
LA59_RS10070	COG0583	DNA-binding transcription factor activity
LA59_RS10115	COG4139	cobalamin transport
LA59_RS10130	COG2062	phosphohistidine phosphatase, SixA
LA59_RS10140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LA59_RS10150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LA59_RS10155	COG0702	epimerase
LA59_RS10160	COG1823	symporter activity
LA59_RS10170	COG2925	Exonuclease
LA59_RS10180	COG1346	cytolysis
LA59_RS10245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA59_RS10245	COG0072	phenylalanine-tRNA ligase activity
LA59_RS10300	COG0251	oxidation-reduction process
LA59_RS10310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LA59_RS10335	COG2188	Transcriptional regulator
LA59_RS10345	COG0010	Belongs to the arginase family
LA59_RS10355	COG2986	histidine ammonia-lyase
LA59_RS10370	COG0247	lactate metabolic process
LA59_RS10370	COG0277	FAD linked oxidase domain protein
LA59_RS10440	COG0519	Catalyzes the synthesis of GMP from XMP
LA59_RS10680	COG0662	Cupin 2, conserved barrel domain protein
LA59_RS10955	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LA59_RS10965	COG1403	HNH endonuclease
LA59_RS11040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LA59_RS11055	COG3106	COG3106 Predicted ATPase
LA59_RS11070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LA59_RS11075	COG2205	protein histidine kinase activity
LA59_RS11075	COG0784	Response regulator, receiver
LA59_RS11090	COG0814	amino acid
LA59_RS11095	COG1760	l-serine dehydratase
LA59_RS11100	COG5001	Diguanylate cyclase
LA59_RS11100	COG3300	MHYT domain
LA59_RS11110	COG2197	response regulator
LA59_RS11115	COG0720	synthase
LA59_RS11120	COG0840	transmembrane signaling receptor activity
LA59_RS11125	COG0017	Asparaginyl-tRNA synthetase
LA59_RS11140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA59_RS11155	COG2770	Histidine kinase
LA59_RS11155	COG3437	response regulator, receiver
LA59_RS11160	COG1448	Aminotransferase
LA59_RS11185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA59_RS11190	COG1846	Transcriptional regulator
LA59_RS11215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LA59_RS11230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA59_RS11235	COG3108	Peptidase M15
LA59_RS11240	COG2989	Protein conserved in bacteria
LA59_RS11265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LA59_RS11275	COG3088	subunit of a heme lyase
LA59_RS11275	COG4235	cytochrome complex assembly
LA59_RS11285	COG1138	Cytochrome C-type biogenesis protein
LA59_RS11290	COG3301	Polysulphide reductase, NrfD
LA59_RS11295	COG0437	4 iron, 4 sulfur cluster binding
LA59_RS11305	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LA59_RS11325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA59_RS11335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA59_RS11340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA59_RS11365	COG0019	diaminopimelate decarboxylase activity
LA59_RS11410	COG0322	excinuclease ABC activity
LA59_RS11415	COG2197	response regulator
LA59_RS11420	COG0417	DNA replication proofreading
LA59_RS11440	COG1187	pseudouridine synthase activity
LA59_RS11450	COG0009	L-threonylcarbamoyladenylate synthase
LA59_RS11455	COG0613	PHP domain protein
LA59_RS11465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LA59_RS11470	COG0512	Glutamine amidotransferase of anthranilate synthase
LA59_RS11480	COG0135	phosphoribosylanthranilate isomerase activity
LA59_RS11480	COG0134	indole-3-glycerol-phosphate synthase activity
LA59_RS11490	COG0159	tryptophan synthase activity
LA59_RS11495	COG1301	dicarboxylic acid transport
LA59_RS11520	COG1607	acyl-coa hydrolase
LA59_RS11525	COG2350	Protein conserved in bacteria
LA59_RS11540	COG0583	DNA-binding transcription factor activity
LA59_RS11555	COG1716	ATPase activity
LA59_RS11555	COG5001	Diguanylate cyclase
LA59_RS11560	COG1032	radical SAM domain protein
LA59_RS11585	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA59_RS11600	COG2964	Protein conserved in bacteria
LA59_RS11605	COG0840	transmembrane signaling receptor activity
LA59_RS11615	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LA59_RS11620	COG0463	Glycosyl transferase, family 2
LA59_RS11625	COG0745	RESPONSE REGULATOR receiver
LA59_RS11630	COG3850	Histidine kinase
LA59_RS11630	COG5002	protein histidine kinase activity
LA59_RS11665	COG1846	Transcriptional regulator
LA59_RS11710	COG0577	efflux transmembrane transporter activity
LA59_RS11710	COG1136	(ABC) transporter
LA59_RS11720	COG0577	efflux transmembrane transporter activity
LA59_RS11745	COG3153	acetyltransferase
LA59_RS11775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA59_RS11785	COG3118	belongs to the thioredoxin family
LA59_RS11790	COG4232	protein-disulfide reductase activity
LA59_RS11805	COG2995	paraquat-inducible protein a
LA59_RS11810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA59_RS11810	COG3008	intermembrane lipid transfer
LA59_RS11815	COG3009	Protein conserved in bacteria
LA59_RS11870	COG4166	transmembrane transport
LA59_RS11880	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LA59_RS11885	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LA59_RS11895	COG0539	negative regulation of cytoplasmic translation
LA59_RS11905	COG0616	signal peptide processing
LA59_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_RS11930	COG0835	chemotaxis
LA59_RS11930	COG0784	Response regulator, receiver
LA59_RS11935	COG1940	carbohydrate kinase activity
LA59_RS11945	COG4667	esterase of the alpha-beta hydrolase superfamily
LA59_RS11955	COG0733	neurotransmitter:sodium symporter activity
LA59_RS11965	COG1263	PTS System
LA59_RS11965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_RS11970	COG0084	hydrolase, TatD family'
LA59_RS11985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LA59_RS12015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LA59_RS12030	COG1399	metal-binding, possibly nucleic acid-binding protein
LA59_RS12035	COG0424	maF-like protein
LA59_RS12040	COG0564	pseudouridine synthase activity
LA59_RS12055	COG0659	secondary active sulfate transmembrane transporter activity
LA59_RS12060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LA59_RS12065	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LA59_RS12095	COG2186	Transcriptional regulator
LA59_RS12105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LA59_RS12110	COG0653	protein targeting
LA59_RS12115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA59_RS12120	COG3706	GGDEF domain
LA59_RS12125	COG0366	Alpha amylase catalytic
LA59_RS12130	COG1122	ATPase activity
LA59_RS12135	COG4120	Belongs to the binding-protein-dependent transport system permease family
LA59_RS12160	COG0280	phosphate acetyltransferase
LA59_RS12160	COG0857	belongs to the CobB CobQ family
LA59_RS12165	COG3174	membrane
LA59_RS12170	COG0435	Glutathione S-transferase
LA59_RS12180	COG0444	Belongs to the ABC transporter superfamily
LA59_RS12185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_RS12190	COG0601	transmembrane transport
LA59_RS12200	COG0314	molybdopterin synthase activity
LA59_RS12205	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LA59_RS12215	COG0521	Mo-molybdopterin cofactor biosynthetic process
LA59_RS12220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LA59_RS12225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LA59_RS12240	COG0556	nucleotide-excision repair
LA59_RS12250	COG1882	Formate acetyltransferase
LA59_RS12255	COG4657	Part of a membrane complex involved in electron transport
LA59_RS12265	COG4656	Part of a membrane complex involved in electron transport
LA59_RS12270	COG4658	electron transport chain
LA59_RS12275	COG4659	FMN binding
LA59_RS12280	COG4660	Part of a membrane complex involved in electron transport
LA59_RS12285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LA59_RS12290	COG0346	lactoylglutathione lyase activity
LA59_RS12300	COG2885	chlorophyll binding
LA59_RS12310	COG2056	Na+-H+ antiporter family
LA59_RS12370	COG3504	Conjugal transfer protein
LA59_RS12400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA59_RS12410	COG3457	Alanine racemase
LA59_RS12435	COG1278	Cold shock
LA59_RS12455	COG3457	Alanine racemase
LA59_RS12480	COG0330	HflC and HflK could
LA59_RS12490	COG0861	Integral membrane protein TerC family
LA59_RS12495	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_RS12505	COG0633	Ferredoxin
LA59_RS12505	COG3217	Mosc domain protein beta barrel domain protein
LA59_RS12515	COG0583	DNA-binding transcription factor activity
LA59_RS12525	COG2814	Major facilitator Superfamily
LA59_RS12610	COG0784	Response regulator, receiver
LA59_RS12610	COG2205	protein histidine kinase activity
LA59_RS12620	COG2003	Belongs to the UPF0758 family
LA59_RS12675	COG4974	Belongs to the 'phage' integrase family
LA59_RS12680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA59_RS12700	COG1454	alcohol dehydrogenase
LA59_RS12700	COG1012	belongs to the aldehyde dehydrogenase family
LA59_RS12705	COG2095	MarC family integral membrane protein
LA59_RS12710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA59_RS12715	COG2165	general secretion pathway protein
LA59_RS12720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LA59_RS12725	COG1757	Na H antiporter
LA59_RS12750	COG3083	sulfuric ester hydrolase activity
LA59_RS12760	COG0123	including yeast histone deacetylase and acetoin utilization protein
LA59_RS12775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA59_RS12780	COG0778	Nitroreductase
LA59_RS12785	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA59_RS12785	COG1902	pentaerythritol trinitrate reductase activity
LA59_RS12790	COG0616	signal peptide processing
LA59_RS12795	COG0252	asparaginase activity
LA59_RS12800	COG3139	Protein of unknown function (DUF1315)
LA59_RS12810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA59_RS12815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA59_RS12835	COG2226	methyltransferase
LA59_RS12855	COG1785	Belongs to the alkaline phosphatase family
LA59_RS12865	COG0346	lactoylglutathione lyase activity
LA59_RS12870	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LA59_RS12875	COG0668	transmembrane transport
LA59_RS12880	COG2261	transglycosylase associated protein
LA59_RS12885	COG2983	Belongs to the UPF0260 family
LA59_RS12895	COG2964	Protein conserved in bacteria
LA59_RS12905	COG0251	oxidation-reduction process
LA59_RS12910	COG0814	amino acid
LA59_RS12915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LA59_RS12920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LA59_RS12930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LA59_RS12940	COG2832	Protein of unknown function (DUF454)
LA59_RS12945	COG0745	RESPONSE REGULATOR receiver
LA59_RS12950	COG0583	DNA-binding transcription factor activity
LA59_RS12955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LA59_RS12960	COG1286	toxin biosynthetic process
LA59_RS12965	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LA59_RS12970	COG0285	dihydrofolate synthase activity
LA59_RS12990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LA59_RS12995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA59_RS13000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LA59_RS13020	COG3101	peptidyl-lysine hydroxylation
LA59_RS13025	COG2860	membrane
LA59_RS13035	COG2890	protein-(glutamine-N5) methyltransferase activity
LA59_RS13045	COG2062	phosphohistidine phosphatase, SixA
LA59_RS13060	COG0183	Belongs to the thiolase family
LA59_RS13085	COG2853	Lipoprotein
LA59_RS13090	COG3088	subunit of a heme lyase
LA59_RS13090	COG4235	cytochrome complex assembly
LA59_RS13100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA59_RS13105	COG1138	Cytochrome C-type biogenesis protein
LA59_RS13120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA59_RS13125	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA59_RS13130	COG4133	protoheme IX ABC transporter activity
LA59_RS13140	COG0835	chemotaxis
LA59_RS13150	COG1192	Involved in chromosome partitioning
LA59_RS13155	COG2201	protein-glutamate methylesterase activity
LA59_RS13160	COG0643	Histidine kinase
LA59_RS13160	COG0784	Response regulator, receiver
LA59_RS13160	COG2198	Histidine kinase
LA59_RS13165	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LA59_RS13200	COG1684	flagellar biosynthetic protein fliR
LA59_RS13205	COG1987	bacterial-type flagellum assembly
LA59_RS13260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LA59_RS13270	COG1677	Flagellar hook-basal body complex protein FliE
LA59_RS13290	COG1516	flagellar protein fliS
LA59_RS13300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LA59_RS13305	COG1334	flagellar protein FlaG
LA59_RS13310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_RS13315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_RS13325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_RS13330	COG2211	Major facilitator Superfamily
LA59_RS13335	COG1486	melibiose metabolic process
LA59_RS13340	COG2169	Transcriptional regulator
LA59_RS13345	COG2837	iron assimilation
LA59_RS13370	COG1393	Belongs to the ArsC family
LA59_RS13390	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LA59_RS13395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LA59_RS13400	COG2716	regulation of RNA biosynthetic process
LA59_RS13405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LA59_RS13420	COG4783	chaperone-mediated protein folding
LA59_RS13425	COG1393	Belongs to the ArsC family
LA59_RS13445	COG2233	PERMEase
LA59_RS13450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LA59_RS13455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LA59_RS13460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LA59_RS13465	COG0121	glutamine amidotransferase
LA59_RS13470	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LA59_RS13495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LA59_RS13505	COG2226	methyltransferase
LA59_RS13515	COG0741	lytic transglycosylase activity
LA59_RS13515	COG1388	LysM domain
LA59_RS13530	COG0347	Belongs to the P(II) protein family
LA59_RS13550	COG0587	DNA-directed DNA polymerase activity
LA59_RS13575	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA59_RS13580	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LA59_RS13590	COG0750	zinc metalloprotease
LA59_RS13600	COG0575	Belongs to the CDS family
LA59_RS13605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LA59_RS13630	COG0024	Methionine aminopeptidase
LA59_RS13645	COG0564	pseudouridine synthase activity
LA59_RS13650	COG3098	single-species biofilm formation
LA59_RS13690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA59_RS13715	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LA59_RS13725	COG1720	tRNA m6t6A37 methyltransferase activity
LA59_RS13750	COG0733	neurotransmitter:sodium symporter activity
LA59_RS13765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA59_RS13770	COG0514	ATP-dependent DNA helicase (RecQ)
LA59_RS13775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LA59_RS13790	COG1477	protein flavinylation
LA59_RS13800	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LA59_RS13825	COG0271	Belongs to the BolA IbaG family
LA59_RS13855	COG1595	DNA-templated transcription, initiation
LA59_RS13870	COG3248	Nucleoside-binding outer membrane protein
LA59_RS13875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LA59_RS13880	COG0693	protein deglycase activity
LA59_RS13885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LA59_RS13890	COG2166	iron-sulfur cluster assembly
LA59_RS13895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LA59_RS13900	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LA59_RS13910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LA59_RS13910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LA59_RS13920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LA59_RS13925	COG1074	ATP-dependent DNA helicase activity
LA59_RS13930	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LA59_RS13950	COG3141	response to X-ray
LA59_RS13965	COG2171	N-acyltransferase activity
LA59_RS13970	COG0584	glycerophosphoryl diester phosphodiesterase
LA59_RS13975	COG2271	Major facilitator Superfamily
LA59_RS13980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LA59_RS13990	COG1349	DNA-binding transcription factor activity
LA59_RS13995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LA59_RS14015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA59_RS14025	COG2017	converts alpha-aldose to the beta-anomer
LA59_RS14040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LA59_RS14045	COG0768	penicillin binding
LA59_RS14055	COG1609	Transcriptional regulator
LA59_RS14060	COG3250	beta-galactosidase activity
LA59_RS14065	COG2731	YhcH YjgK YiaL family protein
LA59_RS14070	COG0531	amino acid
LA59_RS14075	COG0583	DNA-binding transcription factor activity
LA59_RS14135	COG4964	Belongs to the GSP D family
LA59_RS14160	COG2169	Transcriptional regulator
LA59_RS14165	COG1022	Amp-dependent synthetase and ligase
LA59_RS14175	COG0583	DNA-binding transcription factor activity
LA59_RS14180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LA59_RS14185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LA59_RS14195	COG0560	Phosphoserine phosphatase
LA59_RS14205	COG0813	purine-nucleoside phosphorylase activity
LA59_RS14215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LA59_RS14225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA59_RS14230	COG0084	hydrolase, TatD family'
LA59_RS14235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LA59_RS14240	COG3706	GGDEF domain
LA59_RS14260	COG3153	acetyltransferase
LA59_RS14265	COG3154	lipid carrier protein
LA59_RS14275	COG0826	peptidase U32
LA59_RS14280	COG0826	peptidase U32
LA59_RS14285	COG0534	Mate efflux family protein
LA59_RS14305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LA59_RS14325	COG0195	Participates in both transcription termination and antitermination
LA59_RS14345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LA59_RS14355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LA59_RS14360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LA59_RS14370	COG1534	Rna-binding protein
LA59_RS14375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA59_RS14380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LA59_RS14385	COG2027	D-alanyl-D-alanine carboxypeptidase
LA59_RS14395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LA59_RS14400	COG0739	heme binding
LA59_RS14415	COG0316	Belongs to the HesB IscA family
LA59_RS14425	COG0628	permease
LA59_RS14440	COG0784	Response regulator, receiver
LA59_RS14440	COG2198	Histidine kinase
LA59_RS14440	COG2205	protein histidine kinase activity
LA59_RS14440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_RS14445	COG0747	negative chemotaxis
LA59_RS14455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_RS14460	COG0444	Belongs to the ABC transporter superfamily
LA59_RS14465	COG4608	Belongs to the ABC transporter superfamily
LA59_RS14475	COG2971	BadF BadG BcrA BcrD
LA59_RS14490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LA59_RS14495	COG3842	ATPase activity
LA59_RS14505	COG1840	ABC-type Fe3 transport system, periplasmic component
LA59_RS14510	COG0004	ammonium transporteR
LA59_RS14525	COG1049	propionate catabolic process, 2-methylcitrate cycle
LA59_RS14530	COG1752	Esterase of the alpha-beta hydrolase superfamily
LA59_RS14535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA59_RS14540	COG1643	Atp-dependent helicase
LA59_RS14555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA59_RS14565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LA59_RS14580	COG1560	Kdo2-lipid A biosynthetic process
LA59_RS14585	COG0842	Transport permease protein
LA59_RS14590	COG1131	(ABC) transporter
LA59_RS14595	COG0659	secondary active sulfate transmembrane transporter activity
LA59_RS14600	COG0288	reversible hydration of carbon dioxide
LA59_RS14615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA59_RS14620	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA59_RS14625	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LA59_RS14630	COG2186	Transcriptional regulator
LA59_RS14655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA59_RS14660	COG1459	type II secretion system
LA59_RS14670	COG0237	dephospho-CoA kinase activity
LA59_RS14675	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LA59_RS14680	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LA59_RS14705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LA59_RS14710	COG4137	Cytochrome C assembly protein
LA59_RS14715	COG4536	flavin adenine dinucleotide binding
LA59_RS14735	COG0612	Peptidase, M16
LA59_RS14740	COG1238	metal cluster binding
LA59_RS14750	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LA59_RS14755	COG5016	pyruvate
LA59_RS14755	COG0511	ligase activity, forming carbon-carbon bonds
LA59_RS14760	COG3630	sodium ion export across plasma membrane
LA59_RS14820	COG0527	aspartate kinase activity
LA59_RS14835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LA59_RS14840	COG1546	Belongs to the CinA family
LA59_RS14850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA59_RS14880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LA59_RS14890	COG0148	phosphopyruvate hydratase activity
LA59_RS14900	COG3956	TIGRFAM MazG family protein
LA59_RS14905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA59_RS14925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LA59_RS14930	COG1381	Involved in DNA repair and RecF pathway recombination
LA59_RS14935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LA59_RS14955	COG3086	response to oxidative stress
LA59_RS14970	COG1595	DNA-templated transcription, initiation
LA59_RS14975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LA59_RS14985	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LA59_RS15005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA59_RS15010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA59_RS15020	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LA59_RS15030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LA59_RS15040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA59_RS15050	COG0583	DNA-binding transcription factor activity
LA59_RS15065	COG0668	transmembrane transport
LA59_RS15070	COG0191	fructose-bisphosphate aldolase activity
LA59_RS15090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA59_RS15110	COG2356	endonuclease I
LA59_RS15115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA59_RS15120	COG0189	ligase activity
LA59_RS15125	COG1678	Uncharacterized ACR, COG1678
LA59_RS15130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LA59_RS15145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LA59_RS15150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LA59_RS15155	COG0762	integral membrane protein
LA59_RS15170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LA59_RS15175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA59_RS15275	COG1012	belongs to the aldehyde dehydrogenase family
LA59_RS15320	COG3437	response regulator, receiver
LA59_RS15335	COG1486	melibiose metabolic process
LA59_RS15340	COG1447	Phosphotransferase system cellobiose-specific component IIA
LA59_RS15350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LA59_RS15370	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_RS15380	COG0795	lipopolysaccharide-transporting ATPase activity
LA59_RS15385	COG0795	lipopolysaccharide-transporting ATPase activity
LA59_RS15395	COG2927	DNA polymerase III (CHI subunit)
LA59_RS15400	COG0525	valine-tRNA ligase activity
LA59_RS15410	COG0456	acetyltransferase
LA59_RS15445	COG0251	oxidation-reduction process
LA59_RS15450	COG0204	Acyl-transferase
LA59_RS15460	COG5007	Belongs to the BolA IbaG family
LA59_RS15470	COG2854	intermembrane phospholipid transfer
LA59_RS15475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA59_RS15480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LA59_RS15485	COG1127	ABC transporter
LA59_RS15495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LA59_RS15495	COG0517	IMP dehydrogenase activity
LA59_RS15505	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LA59_RS15510	COG1137	ATPase activity
LA59_RS15520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LA59_RS15525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_RS15535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_RS15540	COG2239	Acts as a magnesium transporter
LA59_RS15545	COG0312	modulator of DNA gyrase
LA59_RS15555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA59_RS15560	COG0564	pseudouridine synthase activity
LA59_RS15575	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LA59_RS15580	COG0312	modulator of DNA gyrase
LA59_RS15585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA59_RS15590	COG3164	Protein of unknown function
LA59_RS15600	COG0424	maF-like protein
LA59_RS15605	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LA59_RS15610	COG1792	Involved in formation and maintenance of cell shape
LA59_RS15615	COG1077	Cell shape determining protein MreB Mrl
LA59_RS15650	COG2165	general secretion pathway protein
LA59_RS15660	COG1459	type II secretion system
LA59_RS15665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA59_RS15675	COG3409	Peptidoglycan-binding domain 1 protein
LA59_RS15675	COG3267	Type II secretory pathway component ExeA
LA59_RS15700	COG2199	diguanylate cyclase activity
LA59_RS15700	COG2200	EAL domain
LA59_RS15705	COG0629	single-stranded DNA binding
LA59_RS15720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LA59_RS15730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LA59_RS15735	COG0527	aspartate kinase activity
LA59_RS15740	COG0646	methionine synthase
LA59_RS15740	COG1410	methionine synthase
LA59_RS15805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA59_RS15825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA59_RS15940	COG0735	belongs to the Fur family
LA59_RS15955	COG0432	Pfam Uncharacterised protein family UPF0047
LA59_RS15965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LA59_RS15970	COG0305	Participates in initiation and elongation during chromosome replication
LA59_RS15990	COG0360	Binds together with S18 to 16S ribosomal RNA
LA59_RS15995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LA59_RS16000	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LA59_RS16045	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LA59_RS16055	COG0678	peroxiredoxin activity
LA59_RS16055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LA59_RS16060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA59_RS16070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LA59_RS16070	COG0165	Argininosuccinate lyase
LA59_RS16085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LA59_RS16095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LA59_RS16105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LA59_RS16110	COG0460	homoserine dehydrogenase
LA59_RS16110	COG0527	aspartate kinase activity
LA59_RS16115	COG0626	cystathionine gamma-synthase activity
LA59_RS16125	COG0281	malic enzyme
LA59_RS16135	COG2906	2 iron, 2 sulfur cluster binding
LA59_RS16145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LA59_RS16160	COG2168	tRNA wobble position uridine thiolation
LA59_RS16165	COG2923	Belongs to the DsrF TusC family
LA59_RS16170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LA59_RS16175	COG2964	Protein conserved in bacteria
LA59_RS16180	COG0545	Peptidyl-prolyl cis-trans isomerase
LA59_RS16195	COG1446	asparaginase
LA59_RS16200	COG1047	Peptidyl-prolyl cis-trans
LA59_RS16215	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA59_RS16220	COG0488	(ABC) transporter
LA59_RS16230	COG0429	hydrolase of the alpha beta-hydrolase fold
LA59_RS16240	COG3954	Phosphoribulokinase
LA59_RS16245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA59_RS16265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LA59_RS16270	COG0512	Glutamine amidotransferase of anthranilate synthase
LA59_RS16295	COG0546	phosphoglycolate phosphatase activity
LA59_RS16300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA59_RS16305	COG0557	exoribonuclease II activity
LA59_RS16315	COG1017	nitric oxide dioxygenase activity
LA59_RS16315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA59_RS16320	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LA59_RS16325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LA59_RS16330	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LA59_RS16335	COG0330	HflC and HflK could
LA59_RS16340	COG0330	HflC and HflK could
LA59_RS16345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LA59_RS16360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LA59_RS16370	COG0802	atpase or kinase
LA59_RS16375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LA59_RS16445	COG1162	GTPase activity
LA59_RS16455	COG0471	metal ion transport
LA59_RS16470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LA59_RS16475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA59_RS16480	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LA59_RS16490	COG1045	serine acetyltransferase
LA59_RS16495	COG4942	peptidase
LA59_RS16520	COG1053	succinate dehydrogenase
LA59_RS16525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LA59_RS16555	COG1509	lysine 2,3-aminomutase activity
LA59_RS16580	COG0534	Mate efflux family protein
LA59_RS16590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LA59_RS16595	COG3678	ATP-independent chaperone mediated protein folding
LA59_RS16600	COG0745	RESPONSE REGULATOR receiver
LA59_RS16605	COG2205	protein histidine kinase activity
LA59_RS16610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LA59_RS16615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LA59_RS16620	COG3030	protein affecting phage T7 exclusion by the F plasmid
LA59_RS16625	COG1027	Aspartate ammonia-lyase
LA59_RS16630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LA59_RS16635	COG4232	protein-disulfide reductase activity
LA59_RS16645	COG2095	MarC family integral membrane protein
LA59_RS16655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_RS16675	COG0784	Response regulator, receiver
LA59_RS16675	COG2198	Histidine kinase
LA59_RS16675	COG2205	protein histidine kinase activity
LA59_RS16680	COG2814	Major facilitator Superfamily
LA59_RS16695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LA59_RS16700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LA59_RS16705	COG0511	ligase activity, forming carbon-carbon bonds
LA59_RS16710	COG0439	Biotin carboxylase
LA59_RS16720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA59_RS16725	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LA59_RS16730	COG2199	diguanylate cyclase activity
LA59_RS16880	COG2816	NAD+ diphosphatase activity
LA59_RS17075	COG3161	chorismate lyase activity
LA59_RS17175	COG2199	diguanylate cyclase activity
LA59_RS17175	COG2200	EAL domain
LA59_RS17175	COG3287	FIST C domain
LA59_RS17565	COG0129	dihydroxy-acid dehydratase activity
LA59_RS17995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA59_RS18260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA59_RS18635	COG2089	acid synthase
LA59_RS18910	COG0201	protein transport
LA59_RS18970	COG0737	Belongs to the 5'-nucleotidase family
LA59_RS19190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LA59_RS19395	COG1538	Outer membrane efflux protein
LA59_RS19590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LA59_RS19630	COG2860	membrane
LA59_RS19675	COG0069	glutamate synthase activity
LA59_RS19675	COG0067	glutamate synthase
LA59_RS19675	COG0070	glutamate synthase
LA59_RS19680	COG0070	glutamate synthase
LA59_RS19680	COG0067	glutamate synthase
LA59_RS19680	COG0069	glutamate synthase activity
LA59_RS20095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LA59_RS20310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_RS20745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LA59_RS20940	COG0772	Belongs to the SEDS family
LA59_RS20985	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LA59_RS21090	COG0737	Belongs to the 5'-nucleotidase family
LA59_RS21110	COG2840	Smr protein MutS2
LA59_RS21325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LA59_RS21545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA59_RS22140	COG2855	membrane
LA59_RS22295	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LA59_RS22495	COG1882	Formate acetyltransferase
LA59_RS22625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA59_RS22755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LA59_RS22810	COG0823	Involved in the tonB-independent uptake of proteins
LA59_RS22835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_RS22835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_RS22835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA59_RS23065	COG4792	protein secretion
LA59_RS23160	COG0789	Transcriptional regulator
LA59_RS23305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_RS23595	COG1757	Na H antiporter
LA59_RS23600	COG1757	Na H antiporter
LA59_RS23775	COG0747	negative chemotaxis
LA59_RS23905	COG4135	transport system, permease component
LA59_RS24040	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_RS24260	COG0583	DNA-binding transcription factor activity
LA59_RS24460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA59_RS24985	COG2199	diguanylate cyclase activity
LA59_RS24985	COG2203	Gaf domain
LA59_RS25690	COG0110	maltose O-acetyltransferase activity
LA59_RS25855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LA59_RS25885	COG3290	protein histidine kinase activity
LA59_RS26635	COG2925	Exonuclease