locus-tag	class	description
AL538_RS00010	COG2204	response regulator
AL538_RS00030	COG2885	chlorophyll binding
AL538_RS00040	COG1793	dna ligase
AL538_RS00050	COG0534	Mate efflux family protein
AL538_RS00055	COG0307	riboflavin synthase, alpha
AL538_RS00065	COG3001	Fructosamine kinase
AL538_RS00070	COG2201	protein-glutamate methylesterase activity
AL538_RS00075	COG3706	GGDEF domain
AL538_RS00085	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL538_RS00110	COG0840	transmembrane signaling receptor activity
AL538_RS00120	COG0840	transmembrane signaling receptor activity
AL538_RS00165	COG1454	alcohol dehydrogenase
AL538_RS00180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL538_RS00185	COG1063	alcohol dehydrogenase
AL538_RS00195	COG3119	arylsulfatase activity
AL538_RS00200	COG0641	radical SAM
AL538_RS00205	COG0714	Associated with various cellular activities
AL538_RS00235	COG2188	Transcriptional regulator
AL538_RS00275	COG2003	Belongs to the UPF0758 family
AL538_RS00310	COG1203	CRISPR-associated helicase, Cas3
AL538_RS00340	COG1518	maintenance of DNA repeat elements
AL538_RS00345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL538_RS00405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL538_RS00435	COG3710	Transcriptional regulator
AL538_RS00450	COG4790	Type iii secretion
AL538_RS00515	COG0791	NLP P60 protein
AL538_RS00520	COG0840	transmembrane signaling receptor activity
AL538_RS00525	COG3385	transposase activity
AL538_RS00565	COG3148	PFAM DTW domain containing protein
AL538_RS00570	COG1940	carbohydrate kinase activity
AL538_RS00580	COG0303	'Molybdopterin
AL538_RS00590	COG3842	ATPase activity
AL538_RS00595	COG4662	Binding-protein-dependent transport system inner membrane component
AL538_RS00605	COG2204	response regulator
AL538_RS00610	COG4191	Histidine kinase
AL538_RS00625	COG0488	(ABC) transporter
AL538_RS00630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL538_RS00650	COG3381	protein complex oligomerization
AL538_RS00660	COG3383	formate dehydrogenase (NAD+) activity
AL538_RS00660	COG0243	molybdopterin cofactor binding
AL538_RS00665	COG0437	4 iron, 4 sulfur cluster binding
AL538_RS00685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL538_RS00690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL538_RS00700	COG1177	transmembrane transport
AL538_RS00710	COG3842	ATPase activity
AL538_RS00720	COG2992	FlgJ-related protein
AL538_RS00735	COG0589	response to stress
AL538_RS00740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL538_RS00755	COG2217	Heavy metal translocating P-type atpase
AL538_RS00765	COG2010	Cytochrome c
AL538_RS00780	COG3278	Belongs to the heme-copper respiratory oxidase family
AL538_RS00795	COG0784	Response regulator, receiver
AL538_RS00795	COG2205	protein histidine kinase activity
AL538_RS00800	COG2801	Transposase and inactivated derivatives
AL538_RS00825	COG1067	ATP-dependent peptidase activity
AL538_RS00830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL538_RS00845	COG0488	(ABC) transporter
AL538_RS00870	COG2902	Dehydrogenase
AL538_RS00875	COG0308	aminopeptidase N
AL538_RS00890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL538_RS00895	COG1956	GAF domain-containing protein
AL538_RS00900	COG1132	(ABC) transporter
AL538_RS00905	COG2995	paraquat-inducible protein a
AL538_RS00910	COG3008	intermembrane lipid transfer
AL538_RS00935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL538_RS00950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS00955	COG4597	amino acid ABC transporter
AL538_RS00960	COG0765	amino acid transport
AL538_RS00965	COG1126	abc transporter atp-binding protein
AL538_RS00970	COG0670	Belongs to the BI1 family
AL538_RS00975	COG2920	part of a sulfur-relay system
AL538_RS00980	COG1254	Belongs to the acylphosphatase family
AL538_RS01010	COG3300	MHYT domain
AL538_RS01010	COG5001	Diguanylate cyclase
AL538_RS01015	COG2205	protein histidine kinase activity
AL538_RS01015	COG4999	Histidine kinase
AL538_RS01015	COG3850	Histidine kinase
AL538_RS01015	COG3437	response regulator, receiver
AL538_RS01030	COG0110	maltose O-acetyltransferase activity
AL538_RS01050	COG1846	Transcriptional regulator
AL538_RS01060	COG3247	response to pH
AL538_RS01065	COG0668	transmembrane transport
AL538_RS01075	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL538_RS01135	COG4964	Belongs to the GSP D family
AL538_RS01160	COG2207	Transcriptional regulator
AL538_RS01180	COG0589	response to stress
AL538_RS01185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL538_RS01190	COG0363	glucosamine-6-phosphate deaminase activity
AL538_RS01195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL538_RS01205	COG4774	siderophore transport
AL538_RS01210	COG4565	transcriptional regulatory protein
AL538_RS01215	COG3290	protein histidine kinase activity
AL538_RS01230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS01260	COG0583	DNA-binding transcription factor activity
AL538_RS01275	COG3005	denitrification pathway
AL538_RS01290	COG1999	signal sequence binding
AL538_RS01295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL538_RS01315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL538_RS01345	COG2186	Transcriptional regulator
AL538_RS01360	COG0702	epimerase
AL538_RS01365	COG0583	DNA-binding transcription factor activity
AL538_RS01370	COG1404	Belongs to the peptidase S8 family
AL538_RS01375	COG1858	cytochrome C peroxidase
AL538_RS01385	COG0527	aspartate kinase activity
AL538_RS01390	COG0662	Cupin 2, conserved barrel domain protein
AL538_RS01395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL538_RS01400	COG0456	acetyltransferase
AL538_RS01405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL538_RS01415	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AL538_RS01420	COG0534	Mate efflux family protein
AL538_RS01435	COG1368	sulfuric ester hydrolase activity
AL538_RS01465	COG1115	amino acid carrier protein
AL538_RS01470	COG1012	belongs to the aldehyde dehydrogenase family
AL538_RS01475	COG3284	Transcriptional regulator
AL538_RS01505	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AL538_RS01515	COG3051	citrate lyase alpha subunit
AL538_RS01520	COG2301	Belongs to the HpcH HpaI aldolase family
AL538_RS01530	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AL538_RS01540	COG3630	sodium ion export across plasma membrane
AL538_RS01545	COG0511	ligase activity, forming carbon-carbon bonds
AL538_RS01545	COG5016	pyruvate
AL538_RS01550	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL538_RS01560	COG4565	transcriptional regulatory protein
AL538_RS01600	COG1051	belongs to the nudix hydrolase family
AL538_RS01650	COG0625	glutathione transferase activity
AL538_RS01660	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL538_RS01675	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL538_RS01685	COG0601	transmembrane transport
AL538_RS01690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL538_RS01695	COG0444	Belongs to the ABC transporter superfamily
AL538_RS01715	COG3291	Pkd domain containing protein
AL538_RS01730	COG0745	RESPONSE REGULATOR receiver
AL538_RS01740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS01745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS01765	COG0813	purine-nucleoside phosphorylase activity
AL538_RS01770	COG1177	transmembrane transport
AL538_RS01775	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL538_RS01780	COG3842	ATPase activity
AL538_RS01785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL538_RS01790	COG2423	ornithine cyclodeaminase activity
AL538_RS01805	COG3938	Belongs to the proline racemase family
AL538_RS01835	COG1451	nucleotide metabolic process
AL538_RS01840	COG2165	general secretion pathway protein
AL538_RS01850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS01865	COG0583	DNA-binding transcription factor activity
AL538_RS01925	COG4139	cobalamin transport
AL538_RS01940	COG2062	phosphohistidine phosphatase, SixA
AL538_RS01950	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL538_RS01960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL538_RS01965	COG0702	epimerase
AL538_RS01970	COG1823	symporter activity
AL538_RS01980	COG2925	Exonuclease
AL538_RS01990	COG1346	cytolysis
AL538_RS02055	COG0072	phenylalanine-tRNA ligase activity
AL538_RS02055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL538_RS02065	COG3706	GGDEF domain
AL538_RS02110	COG0251	oxidation-reduction process
AL538_RS02120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL538_RS02145	COG2188	Transcriptional regulator
AL538_RS02155	COG0010	Belongs to the arginase family
AL538_RS02165	COG2986	histidine ammonia-lyase
AL538_RS02180	COG0247	lactate metabolic process
AL538_RS02180	COG0277	FAD linked oxidase domain protein
AL538_RS02215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL538_RS02255	COG0456	acetyltransferase
AL538_RS02490	COG2026	Addiction module toxin, RelE StbE family
AL538_RS02510	COG1403	HNH endonuclease
AL538_RS02525	COG0625	glutathione transferase activity
AL538_RS02540	COG3385	transposase activity
AL538_RS02715	COG3340	Belongs to the peptidase S51 family
AL538_RS02925	COG0110	maltose O-acetyltransferase activity
AL538_RS02945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL538_RS02960	COG3106	COG3106 Predicted ATPase
AL538_RS02975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL538_RS02980	COG2205	protein histidine kinase activity
AL538_RS02980	COG0784	Response regulator, receiver
AL538_RS02995	COG0814	amino acid
AL538_RS03000	COG1760	l-serine dehydratase
AL538_RS03005	COG5001	Diguanylate cyclase
AL538_RS03005	COG3300	MHYT domain
AL538_RS03015	COG2197	response regulator
AL538_RS03020	COG0720	synthase
AL538_RS03025	COG0840	transmembrane signaling receptor activity
AL538_RS03030	COG0017	Asparaginyl-tRNA synthetase
AL538_RS03045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL538_RS03060	COG2770	Histidine kinase
AL538_RS03060	COG3437	response regulator, receiver
AL538_RS03065	COG1448	Aminotransferase
AL538_RS03090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL538_RS03095	COG1846	Transcriptional regulator
AL538_RS03120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL538_RS03135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL538_RS03140	COG3108	Peptidase M15
AL538_RS03145	COG2989	Protein conserved in bacteria
AL538_RS03170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL538_RS03180	COG3088	subunit of a heme lyase
AL538_RS03180	COG4235	cytochrome complex assembly
AL538_RS03190	COG1138	Cytochrome C-type biogenesis protein
AL538_RS03195	COG3301	Polysulphide reductase, NrfD
AL538_RS03200	COG0437	4 iron, 4 sulfur cluster binding
AL538_RS03210	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL538_RS03230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL538_RS03240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL538_RS03245	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL538_RS03270	COG0019	diaminopimelate decarboxylase activity
AL538_RS03315	COG0322	excinuclease ABC activity
AL538_RS03320	COG2197	response regulator
AL538_RS03325	COG0417	DNA replication proofreading
AL538_RS03345	COG1187	pseudouridine synthase activity
AL538_RS03355	COG0009	L-threonylcarbamoyladenylate synthase
AL538_RS03360	COG0613	PHP domain protein
AL538_RS03370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL538_RS03375	COG0512	Glutamine amidotransferase of anthranilate synthase
AL538_RS03385	COG0134	indole-3-glycerol-phosphate synthase activity
AL538_RS03385	COG0135	phosphoribosylanthranilate isomerase activity
AL538_RS03395	COG0159	tryptophan synthase activity
AL538_RS03400	COG1301	dicarboxylic acid transport
AL538_RS03425	COG1607	acyl-coa hydrolase
AL538_RS03430	COG2350	Protein conserved in bacteria
AL538_RS03445	COG0583	DNA-binding transcription factor activity
AL538_RS03460	COG1716	ATPase activity
AL538_RS03460	COG5001	Diguanylate cyclase
AL538_RS03465	COG1032	radical SAM domain protein
AL538_RS03470	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL538_RS03485	COG2964	Protein conserved in bacteria
AL538_RS03490	COG0840	transmembrane signaling receptor activity
AL538_RS03500	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL538_RS03505	COG0463	Glycosyl transferase, family 2
AL538_RS03510	COG0745	RESPONSE REGULATOR receiver
AL538_RS03515	COG5002	protein histidine kinase activity
AL538_RS03515	COG3850	Histidine kinase
AL538_RS03550	COG1846	Transcriptional regulator
AL538_RS03565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL538_RS03595	COG1136	(ABC) transporter
AL538_RS03595	COG0577	efflux transmembrane transporter activity
AL538_RS03605	COG0577	efflux transmembrane transporter activity
AL538_RS03630	COG3153	acetyltransferase
AL538_RS03655	COG3118	belongs to the thioredoxin family
AL538_RS03660	COG4232	protein-disulfide reductase activity
AL538_RS03675	COG2995	paraquat-inducible protein a
AL538_RS03680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL538_RS03680	COG3008	intermembrane lipid transfer
AL538_RS03685	COG3009	Protein conserved in bacteria
AL538_RS03740	COG4166	transmembrane transport
AL538_RS03750	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL538_RS03755	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL538_RS03765	COG0539	negative regulation of cytoplasmic translation
AL538_RS03775	COG0616	signal peptide processing
AL538_RS03780	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS03790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS03820	COG0784	Response regulator, receiver
AL538_RS03820	COG0835	chemotaxis
AL538_RS03825	COG1940	carbohydrate kinase activity
AL538_RS03835	COG4667	esterase of the alpha-beta hydrolase superfamily
AL538_RS03845	COG0733	neurotransmitter:sodium symporter activity
AL538_RS03855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS03855	COG1263	PTS System
AL538_RS03860	COG0084	hydrolase, TatD family'
AL538_RS03875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL538_RS03905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL538_RS03920	COG1399	metal-binding, possibly nucleic acid-binding protein
AL538_RS03925	COG0424	maF-like protein
AL538_RS03930	COG0564	pseudouridine synthase activity
AL538_RS03935	COG1530	ribonuclease E activity
AL538_RS03945	COG0659	secondary active sulfate transmembrane transporter activity
AL538_RS03950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL538_RS03955	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL538_RS03985	COG2186	Transcriptional regulator
AL538_RS03995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL538_RS04000	COG0653	protein targeting
AL538_RS04005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL538_RS04010	COG3706	GGDEF domain
AL538_RS04015	COG0366	Alpha amylase catalytic
AL538_RS04020	COG1122	ATPase activity
AL538_RS04025	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL538_RS04050	COG0857	belongs to the CobB CobQ family
AL538_RS04050	COG0280	phosphate acetyltransferase
AL538_RS04055	COG3174	membrane
AL538_RS04060	COG0435	Glutathione S-transferase
AL538_RS04070	COG0444	Belongs to the ABC transporter superfamily
AL538_RS04075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL538_RS04080	COG0601	transmembrane transport
AL538_RS04090	COG0314	molybdopterin synthase activity
AL538_RS04095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL538_RS04105	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL538_RS04110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL538_RS04115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL538_RS04130	COG0556	nucleotide-excision repair
AL538_RS04140	COG1882	Formate acetyltransferase
AL538_RS04145	COG4657	Part of a membrane complex involved in electron transport
AL538_RS04155	COG4656	Part of a membrane complex involved in electron transport
AL538_RS04160	COG4658	electron transport chain
AL538_RS04165	COG4659	FMN binding
AL538_RS04170	COG4660	Part of a membrane complex involved in electron transport
AL538_RS04175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL538_RS04180	COG0346	lactoylglutathione lyase activity
AL538_RS04190	COG2885	chlorophyll binding
AL538_RS04200	COG2056	Na+-H+ antiporter family
AL538_RS04235	COG3451	type IV secretory pathway VirB4
AL538_RS04255	COG3736	Type IV secretory pathway, component VirB8
AL538_RS04260	COG3504	Conjugal transfer protein
AL538_RS04285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL538_RS04290	COG1683	Conserved Protein
AL538_RS04310	COG0583	DNA-binding transcription factor activity
AL538_RS04320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL538_RS04325	COG0581	inorganic phosphate transmembrane transporter activity
AL538_RS04330	COG0573	inorganic phosphate transmembrane transporter activity
AL538_RS04335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL538_RS04415	COG0326	Molecular chaperone. Has ATPase activity
AL538_RS04430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL538_RS04440	COG2003	Belongs to the UPF0758 family
AL538_RS04465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AL538_RS04465	COG2885	chlorophyll binding
AL538_RS04525	COG4974	Belongs to the 'phage' integrase family
AL538_RS04530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL538_RS04550	COG1012	belongs to the aldehyde dehydrogenase family
AL538_RS04550	COG1454	alcohol dehydrogenase
AL538_RS04555	COG2095	MarC family integral membrane protein
AL538_RS04560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL538_RS04565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL538_RS04570	COG1757	Na H antiporter
AL538_RS04595	COG3083	sulfuric ester hydrolase activity
AL538_RS04605	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL538_RS04620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL538_RS04625	COG0778	Nitroreductase
AL538_RS04630	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL538_RS04630	COG1902	pentaerythritol trinitrate reductase activity
AL538_RS04635	COG0616	signal peptide processing
AL538_RS04640	COG0252	asparaginase activity
AL538_RS04645	COG3139	Protein of unknown function (DUF1315)
AL538_RS04655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL538_RS04660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL538_RS04680	COG2226	methyltransferase
AL538_RS04700	COG1785	Belongs to the alkaline phosphatase family
AL538_RS04710	COG0346	lactoylglutathione lyase activity
AL538_RS04715	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL538_RS04720	COG0668	transmembrane transport
AL538_RS04725	COG2261	transglycosylase associated protein
AL538_RS04735	COG2983	Belongs to the UPF0260 family
AL538_RS04745	COG2964	Protein conserved in bacteria
AL538_RS04755	COG0251	oxidation-reduction process
AL538_RS04760	COG0814	amino acid
AL538_RS04765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL538_RS04770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL538_RS04780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL538_RS04790	COG2832	Protein of unknown function (DUF454)
AL538_RS04795	COG0745	RESPONSE REGULATOR receiver
AL538_RS04800	COG0583	DNA-binding transcription factor activity
AL538_RS04805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL538_RS04810	COG1286	toxin biosynthetic process
AL538_RS04815	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL538_RS04820	COG0285	dihydrofolate synthase activity
AL538_RS04840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL538_RS04845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL538_RS04850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL538_RS04870	COG3101	peptidyl-lysine hydroxylation
AL538_RS04875	COG2860	membrane
AL538_RS04885	COG2890	protein-(glutamine-N5) methyltransferase activity
AL538_RS04895	COG2062	phosphohistidine phosphatase, SixA
AL538_RS04910	COG0183	Belongs to the thiolase family
AL538_RS04925	COG2067	long-chain fatty acid transport protein
AL538_RS04935	COG2853	Lipoprotein
AL538_RS04940	COG4235	cytochrome complex assembly
AL538_RS04940	COG3088	subunit of a heme lyase
AL538_RS04950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL538_RS04955	COG1138	Cytochrome C-type biogenesis protein
AL538_RS04970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL538_RS04975	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL538_RS04980	COG4133	protoheme IX ABC transporter activity
AL538_RS04990	COG0835	chemotaxis
AL538_RS05000	COG1192	Involved in chromosome partitioning
AL538_RS05005	COG2201	protein-glutamate methylesterase activity
AL538_RS05010	COG0784	Response regulator, receiver
AL538_RS05010	COG0643	Histidine kinase
AL538_RS05010	COG2198	Histidine kinase
AL538_RS05015	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL538_RS05050	COG1684	flagellar biosynthetic protein fliR
AL538_RS05055	COG1987	bacterial-type flagellum assembly
AL538_RS05110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL538_RS05120	COG1677	Flagellar hook-basal body complex protein FliE
AL538_RS05140	COG1516	flagellar protein fliS
AL538_RS05150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL538_RS05155	COG1334	flagellar protein FlaG
AL538_RS05160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS05165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS05175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS05180	COG2211	Major facilitator Superfamily
AL538_RS05185	COG1486	melibiose metabolic process
AL538_RS05190	COG2169	Transcriptional regulator
AL538_RS05195	COG2837	iron assimilation
AL538_RS05220	COG1393	Belongs to the ArsC family
AL538_RS05240	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL538_RS05245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL538_RS05250	COG2716	regulation of RNA biosynthetic process
AL538_RS05255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL538_RS05270	COG4783	chaperone-mediated protein folding
AL538_RS05275	COG1393	Belongs to the ArsC family
AL538_RS05295	COG2233	PERMEase
AL538_RS05300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL538_RS05305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL538_RS05310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL538_RS05315	COG0121	glutamine amidotransferase
AL538_RS05320	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL538_RS05345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL538_RS05355	COG2226	methyltransferase
AL538_RS05365	COG0741	lytic transglycosylase activity
AL538_RS05365	COG1388	LysM domain
AL538_RS05380	COG0347	Belongs to the P(II) protein family
AL538_RS05400	COG0587	DNA-directed DNA polymerase activity
AL538_RS05425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL538_RS05430	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL538_RS05440	COG0750	zinc metalloprotease
AL538_RS05450	COG0575	Belongs to the CDS family
AL538_RS05455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL538_RS05480	COG0024	Methionine aminopeptidase
AL538_RS05495	COG0564	pseudouridine synthase activity
AL538_RS05500	COG3098	single-species biofilm formation
AL538_RS05540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL538_RS05565	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL538_RS05575	COG1720	tRNA m6t6A37 methyltransferase activity
AL538_RS05600	COG0733	neurotransmitter:sodium symporter activity
AL538_RS05615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL538_RS05620	COG0514	ATP-dependent DNA helicase (RecQ)
AL538_RS05625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL538_RS05640	COG1477	protein flavinylation
AL538_RS05650	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL538_RS05675	COG0271	Belongs to the BolA IbaG family
AL538_RS05705	COG1595	DNA-templated transcription, initiation
AL538_RS05720	COG3248	Nucleoside-binding outer membrane protein
AL538_RS05725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL538_RS05730	COG0693	protein deglycase activity
AL538_RS05735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL538_RS05740	COG2166	iron-sulfur cluster assembly
AL538_RS05745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL538_RS05750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL538_RS05760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL538_RS05760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL538_RS05770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL538_RS05775	COG1074	ATP-dependent DNA helicase activity
AL538_RS05780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL538_RS05800	COG3141	response to X-ray
AL538_RS05815	COG2171	N-acyltransferase activity
AL538_RS05820	COG0584	glycerophosphoryl diester phosphodiesterase
AL538_RS05825	COG2271	Major facilitator Superfamily
AL538_RS05830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL538_RS05840	COG1349	DNA-binding transcription factor activity
AL538_RS05845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL538_RS05870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL538_RS05880	COG2017	converts alpha-aldose to the beta-anomer
AL538_RS05895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL538_RS05900	COG0768	penicillin binding
AL538_RS05910	COG1609	Transcriptional regulator
AL538_RS05915	COG3250	beta-galactosidase activity
AL538_RS05920	COG2731	YhcH YjgK YiaL family protein
AL538_RS05925	COG0531	amino acid
AL538_RS05930	COG0583	DNA-binding transcription factor activity
AL538_RS05990	COG4964	Belongs to the GSP D family
AL538_RS06015	COG2169	Transcriptional regulator
AL538_RS06020	COG1022	Amp-dependent synthetase and ligase
AL538_RS06030	COG0583	DNA-binding transcription factor activity
AL538_RS06035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL538_RS06040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL538_RS06050	COG0560	Phosphoserine phosphatase
AL538_RS06060	COG0813	purine-nucleoside phosphorylase activity
AL538_RS06070	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL538_RS06080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL538_RS06085	COG0084	hydrolase, TatD family'
AL538_RS06090	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL538_RS06095	COG3706	GGDEF domain
AL538_RS06115	COG3153	acetyltransferase
AL538_RS06120	COG3154	lipid carrier protein
AL538_RS06130	COG0826	peptidase U32
AL538_RS06135	COG0826	peptidase U32
AL538_RS06140	COG0534	Mate efflux family protein
AL538_RS06160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL538_RS06180	COG0195	Participates in both transcription termination and antitermination
AL538_RS06200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL538_RS06210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL538_RS06215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL538_RS06225	COG1534	Rna-binding protein
AL538_RS06230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL538_RS06235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL538_RS06240	COG2027	D-alanyl-D-alanine carboxypeptidase
AL538_RS06250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL538_RS06255	COG0739	heme binding
AL538_RS06270	COG0316	Belongs to the HesB IscA family
AL538_RS06280	COG0628	permease
AL538_RS06295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS06295	COG0784	Response regulator, receiver
AL538_RS06295	COG2205	protein histidine kinase activity
AL538_RS06295	COG2198	Histidine kinase
AL538_RS06300	COG0747	negative chemotaxis
AL538_RS06310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL538_RS06315	COG0444	Belongs to the ABC transporter superfamily
AL538_RS06320	COG4608	Belongs to the ABC transporter superfamily
AL538_RS06330	COG2971	BadF BadG BcrA BcrD
AL538_RS06345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL538_RS06350	COG3842	ATPase activity
AL538_RS06360	COG1840	ABC-type Fe3 transport system, periplasmic component
AL538_RS06365	COG0004	ammonium transporteR
AL538_RS06380	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL538_RS06385	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL538_RS06390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL538_RS06395	COG1643	Atp-dependent helicase
AL538_RS06410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL538_RS06420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL538_RS06435	COG1560	Kdo2-lipid A biosynthetic process
AL538_RS06440	COG0842	Transport permease protein
AL538_RS06445	COG1131	(ABC) transporter
AL538_RS06450	COG0659	secondary active sulfate transmembrane transporter activity
AL538_RS06455	COG0288	reversible hydration of carbon dioxide
AL538_RS06470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL538_RS06475	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL538_RS06480	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL538_RS06485	COG2186	Transcriptional regulator
AL538_RS06510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL538_RS06515	COG1459	type II secretion system
AL538_RS06525	COG0237	dephospho-CoA kinase activity
AL538_RS06530	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL538_RS06535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL538_RS06560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL538_RS06565	COG4137	Cytochrome C assembly protein
AL538_RS06570	COG4536	flavin adenine dinucleotide binding
AL538_RS06590	COG0612	Peptidase, M16
AL538_RS06595	COG1238	metal cluster binding
AL538_RS06605	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL538_RS06610	COG5016	pyruvate
AL538_RS06610	COG0511	ligase activity, forming carbon-carbon bonds
AL538_RS06615	COG3630	sodium ion export across plasma membrane
AL538_RS06675	COG0527	aspartate kinase activity
AL538_RS06690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL538_RS06695	COG1546	Belongs to the CinA family
AL538_RS06705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL538_RS06735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL538_RS06745	COG0148	phosphopyruvate hydratase activity
AL538_RS06755	COG3956	TIGRFAM MazG family protein
AL538_RS06760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL538_RS06780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL538_RS06785	COG1381	Involved in DNA repair and RecF pathway recombination
AL538_RS06790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL538_RS06810	COG3086	response to oxidative stress
AL538_RS06825	COG1595	DNA-templated transcription, initiation
AL538_RS06830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL538_RS06840	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL538_RS06860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL538_RS06865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL538_RS06875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL538_RS06885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL538_RS06895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL538_RS06905	COG0583	DNA-binding transcription factor activity
AL538_RS06920	COG0668	transmembrane transport
AL538_RS06925	COG0191	fructose-bisphosphate aldolase activity
AL538_RS06945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL538_RS06965	COG2356	endonuclease I
AL538_RS06970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL538_RS06975	COG0189	ligase activity
AL538_RS06980	COG1678	Uncharacterized ACR, COG1678
AL538_RS06985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL538_RS07000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL538_RS07005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL538_RS07010	COG0762	integral membrane protein
AL538_RS07025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL538_RS07030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL538_RS07130	COG1012	belongs to the aldehyde dehydrogenase family
AL538_RS07175	COG3437	response regulator, receiver
AL538_RS07190	COG1486	melibiose metabolic process
AL538_RS07195	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL538_RS07205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL538_RS07225	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS07235	COG0795	lipopolysaccharide-transporting ATPase activity
AL538_RS07240	COG0795	lipopolysaccharide-transporting ATPase activity
AL538_RS07250	COG2927	DNA polymerase III (CHI subunit)
AL538_RS07255	COG0525	valine-tRNA ligase activity
AL538_RS07265	COG0456	acetyltransferase
AL538_RS07300	COG0251	oxidation-reduction process
AL538_RS07305	COG0204	Acyl-transferase
AL538_RS07315	COG5007	Belongs to the BolA IbaG family
AL538_RS07325	COG2854	intermembrane phospholipid transfer
AL538_RS07330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL538_RS07335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL538_RS07340	COG1127	ABC transporter
AL538_RS07350	COG0517	IMP dehydrogenase activity
AL538_RS07350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL538_RS07360	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL538_RS07365	COG1137	ATPase activity
AL538_RS07375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL538_RS07380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS07390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS07395	COG2239	Acts as a magnesium transporter
AL538_RS07400	COG0312	modulator of DNA gyrase
AL538_RS07410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL538_RS07415	COG0564	pseudouridine synthase activity
AL538_RS07430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL538_RS07445	COG3164	Protein of unknown function
AL538_RS07455	COG0424	maF-like protein
AL538_RS07460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL538_RS07465	COG1792	Involved in formation and maintenance of cell shape
AL538_RS07470	COG1077	Cell shape determining protein MreB Mrl
AL538_RS07505	COG2165	general secretion pathway protein
AL538_RS07515	COG1459	type II secretion system
AL538_RS07520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL538_RS07530	COG3409	Peptidoglycan-binding domain 1 protein
AL538_RS07530	COG3267	Type II secretory pathway component ExeA
AL538_RS07555	COG2200	EAL domain
AL538_RS07555	COG2199	diguanylate cyclase activity
AL538_RS07560	COG0629	single-stranded DNA binding
AL538_RS07585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL538_RS07590	COG0527	aspartate kinase activity
AL538_RS07595	COG0646	methionine synthase
AL538_RS07595	COG1410	methionine synthase
AL538_RS07660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL538_RS07680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL538_RS07685	COG0735	belongs to the Fur family
AL538_RS07700	COG0432	Pfam Uncharacterised protein family UPF0047
AL538_RS07710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL538_RS07715	COG0305	Participates in initiation and elongation during chromosome replication
AL538_RS07735	COG0360	Binds together with S18 to 16S ribosomal RNA
AL538_RS07740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL538_RS07745	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL538_RS07790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL538_RS07800	COG0678	peroxiredoxin activity
AL538_RS07800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL538_RS07805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL538_RS07815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL538_RS07815	COG0165	Argininosuccinate lyase
AL538_RS07830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL538_RS07840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL538_RS07850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL538_RS07855	COG0527	aspartate kinase activity
AL538_RS07855	COG0460	homoserine dehydrogenase
AL538_RS07860	COG0626	cystathionine gamma-synthase activity
AL538_RS07870	COG0281	malic enzyme
AL538_RS07880	COG2906	2 iron, 2 sulfur cluster binding
AL538_RS07890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL538_RS07905	COG2168	tRNA wobble position uridine thiolation
AL538_RS07910	COG2923	Belongs to the DsrF TusC family
AL538_RS07915	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL538_RS07920	COG2964	Protein conserved in bacteria
AL538_RS07925	COG0545	Peptidyl-prolyl cis-trans isomerase
AL538_RS07940	COG1446	asparaginase
AL538_RS07945	COG1047	Peptidyl-prolyl cis-trans
AL538_RS07960	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL538_RS07965	COG0488	(ABC) transporter
AL538_RS07975	COG0429	hydrolase of the alpha beta-hydrolase fold
AL538_RS07985	COG3954	Phosphoribulokinase
AL538_RS07990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL538_RS08010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL538_RS08015	COG0512	Glutamine amidotransferase of anthranilate synthase
AL538_RS08040	COG0546	phosphoglycolate phosphatase activity
AL538_RS08045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL538_RS08050	COG0557	exoribonuclease II activity
AL538_RS08060	COG1017	nitric oxide dioxygenase activity
AL538_RS08060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL538_RS08065	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL538_RS08070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL538_RS08075	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL538_RS08080	COG0330	HflC and HflK could
AL538_RS08085	COG0330	HflC and HflK could
AL538_RS08090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL538_RS08105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL538_RS08115	COG0802	atpase or kinase
AL538_RS08120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL538_RS08190	COG1162	GTPase activity
AL538_RS08200	COG0471	metal ion transport
AL538_RS08215	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL538_RS08220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL538_RS08225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL538_RS08235	COG1045	serine acetyltransferase
AL538_RS08240	COG4942	peptidase
AL538_RS08265	COG1053	succinate dehydrogenase
AL538_RS08270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL538_RS08300	COG1509	lysine 2,3-aminomutase activity
AL538_RS08350	COG0534	Mate efflux family protein
AL538_RS08360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL538_RS08365	COG3678	ATP-independent chaperone mediated protein folding
AL538_RS08370	COG0745	RESPONSE REGULATOR receiver
AL538_RS08375	COG2205	protein histidine kinase activity
AL538_RS08380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL538_RS08385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL538_RS08390	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL538_RS08395	COG1027	Aspartate ammonia-lyase
AL538_RS08400	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL538_RS08405	COG4232	protein-disulfide reductase activity
AL538_RS08415	COG2095	MarC family integral membrane protein
AL538_RS08425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS08445	COG2205	protein histidine kinase activity
AL538_RS08445	COG0784	Response regulator, receiver
AL538_RS08445	COG2198	Histidine kinase
AL538_RS08450	COG2814	Major facilitator Superfamily
AL538_RS08465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL538_RS08470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL538_RS08475	COG0511	ligase activity, forming carbon-carbon bonds
AL538_RS08480	COG0439	Biotin carboxylase
AL538_RS08490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL538_RS08495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL538_RS08500	COG2199	diguanylate cyclase activity
AL538_RS08555	COG1982	Orn Lys Arg decarboxylase major
AL538_RS08560	COG0531	amino acid
AL538_RS08570	COG3710	Transcriptional regulator
AL538_RS08575	COG0789	Transcriptional regulator
AL538_RS08590	COG0151	Belongs to the GarS family
AL538_RS08605	COG1253	flavin adenine dinucleotide binding
AL538_RS08610	COG3068	Protein conserved in bacteria
AL538_RS08620	COG1573	uracil-dna glycosylase
AL538_RS08640	COG2816	NAD+ diphosphatase activity
AL538_RS08645	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL538_RS08665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL538_RS08680	COG0250	Participates in transcription elongation, termination and antitermination
AL538_RS08685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL538_RS08725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL538_RS08735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL538_RS08880	COG3339	Conserved Protein
AL538_RS08895	COG2003	Belongs to the UPF0758 family
AL538_RS08915	COG0582	viral genome integration into host DNA
AL538_RS08930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL538_RS08935	COG0534	Mate efflux family protein
AL538_RS08950	COG2937	Belongs to the GPAT DAPAT family
AL538_RS08960	COG3161	chorismate lyase activity
AL538_RS08965	COG1580	Controls the rotational direction of flagella during chemotaxis
AL538_RS08970	COG0705	Rhomboid family
AL538_RS08985	COG2177	Part of the ABC transporter FtsEX involved in
AL538_RS08990	COG2884	Cell division ATP-binding protein ftsE
AL538_RS08995	COG0552	protein localization to endoplasmic reticulum
AL538_RS09000	COG0742	ribosomal rna small subunit methyltransferase
AL538_RS09010	COG2095	MarC family integral membrane protein
AL538_RS09055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL538_RS09060	COG0640	Transcriptional regulator
AL538_RS09065	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL538_RS09070	COG1280	lysine exporter protein (LysE YggA)
AL538_RS09075	COG2267	carboxylic ester hydrolase activity
AL538_RS09080	COG0561	phosphatase activity
AL538_RS09095	COG3148	PFAM DTW domain containing protein
AL538_RS09100	COG2199	diguanylate cyclase activity
AL538_RS09100	COG2200	EAL domain
AL538_RS09100	COG3287	FIST C domain
AL538_RS09105	COG1011	Hydrolase
AL538_RS09125	COG0019	diaminopimelate decarboxylase activity
AL538_RS09140	COG3072	Adenylate cyclase
AL538_RS09150	COG1587	Uroporphyrinogen-III synthase
AL538_RS09155	COG2959	enzyme of heme biosynthesis
AL538_RS09160	COG3071	HemY protein
AL538_RS09200	COG0633	Ferredoxin
AL538_RS09205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL538_RS09220	COG3118	belongs to the thioredoxin family
AL538_RS09235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL538_RS09245	COG0514	ATP-dependent DNA helicase (RecQ)
AL538_RS09250	COG2962	Rard protein
AL538_RS09260	COG1280	lysine exporter protein (LysE YggA)
AL538_RS09265	COG0405	Gamma-glutamyltransferase
AL538_RS09275	COG0210	DNA helicase
AL538_RS09285	COG3220	belongs to the UPF0276 family
AL538_RS09305	COG2814	Major facilitator Superfamily
AL538_RS09315	COG0006	proline dipeptidase activity
AL538_RS09315	COG0006	proline dipeptidase activity
AL538_RS09330	COG2104	thiamine diphosphate biosynthetic process
AL538_RS09335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL538_RS09355	COG2132	Multicopper oxidase
AL538_RS09400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL538_RS09410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL538_RS09425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL538_RS09430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL538_RS09435	COG0551	DNA topoisomerase type I activity
AL538_RS09445	COG0758	DNA mediated transformation
AL538_RS09465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL538_RS09465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL538_RS09470	COG0569	domain protein
AL538_RS09475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL538_RS09485	COG1272	protein, Hemolysin III
AL538_RS09490	COG4326	sporulation control protein
AL538_RS09495	COG3084	Protein conserved in bacteria
AL538_RS09505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL538_RS09510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL538_RS09515	COG0204	Acyl-transferase
AL538_RS09525	COG3706	GGDEF domain
AL538_RS09530	COG0606	chelatase, subunit chli
AL538_RS09540	COG3978	acetolactate synthase activity
AL538_RS09545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL538_RS09550	COG0129	dihydroxy-acid dehydratase activity
AL538_RS09560	COG0583	DNA-binding transcription factor activity
AL538_RS09565	COG2814	Major facilitator Superfamily
AL538_RS09575	COG0765	amino acid transport
AL538_RS09585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL538_RS09595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL538_RS09620	COG0356	it plays a direct role in the translocation of protons across the membrane
AL538_RS09625	COG3312	ion transport
AL538_RS09630	COG1475	DNA binding
AL538_RS09635	COG1192	Involved in chromosome partitioning
AL538_RS09645	COG0445	tRNA wobble uridine modification
AL538_RS09650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL538_RS09675	COG1126	abc transporter atp-binding protein
AL538_RS09695	COG0592	DNA-directed DNA polymerase activity
AL538_RS09705	COG0187	DNA topoisomerase II activity
AL538_RS09710	COG0071	Belongs to the small heat shock protein (HSP20) family
AL538_RS09715	COG3977	Valine--pyruvate aminotransferase
AL538_RS09720	COG0366	Alpha amylase catalytic
AL538_RS09735	COG2119	membrane
AL538_RS09745	COG0425	Belongs to the sulfur carrier protein TusA family
AL538_RS09760	COG0604	alcohol dehydrogenase
AL538_RS09765	COG0183	Belongs to the thiolase family
AL538_RS09775	COG1739	Uncharacterized protein family UPF0029
AL538_RS09780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL538_RS09825	COG0583	DNA-binding transcription factor activity
AL538_RS09830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL538_RS09835	COG2960	long-chain fatty acid transporting porin activity
AL538_RS09840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS09845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS09850	COG1309	transcriptional regulator
AL538_RS09890	COG0546	phosphoglycolate phosphatase activity
AL538_RS09900	COG4172	Belongs to the ABC transporter superfamily
AL538_RS09905	COG0747	negative chemotaxis
AL538_RS09910	COG0601	transmembrane transport
AL538_RS09915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL538_RS09950	COG1609	Transcriptional regulator
AL538_RS09955	COG0583	DNA-binding transcription factor activity
AL538_RS09960	COG2076	Multidrug Resistance protein
AL538_RS09975	COG0129	dihydroxy-acid dehydratase activity
AL538_RS09980	COG3265	gluconokinase activity
AL538_RS09985	COG2610	gluconate transmembrane transporter activity
AL538_RS09990	COG0800	Aldolase
AL538_RS09995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL538_RS10010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL538_RS10025	COG1522	sequence-specific DNA binding
AL538_RS10030	COG5001	Diguanylate cyclase
AL538_RS10030	COG5002	protein histidine kinase activity
AL538_RS10050	COG0589	response to stress
AL538_RS10060	COG1528	Iron-storage protein
AL538_RS10070	COG2081	HI0933 family
AL538_RS10085	COG1322	Protein conserved in bacteria
AL538_RS10095	COG3165	ubiquinone biosynthetic process from chorismate
AL538_RS10110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL538_RS10115	COG0805	protein transport
AL538_RS10120	COG0084	hydrolase, TatD family'
AL538_RS10135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL538_RS10135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL538_RS10140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL538_RS10170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL538_RS10180	COG2204	response regulator
AL538_RS10185	COG3852	Histidine kinase
AL538_RS10195	COG0174	glutamine synthetase
AL538_RS10200	COG1217	gtp-binding protein TYPA
AL538_RS10220	COG1490	D-aminoacyl-tRNA deacylase activity
AL538_RS10225	COG0456	acetyltransferase
AL538_RS10245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL538_RS10250	COG3031	protein transport across the cell outer membrane
AL538_RS10260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL538_RS10265	COG1459	type II secretion system
AL538_RS10270	COG2165	general secretion pathway protein
AL538_RS10275	COG2165	general secretion pathway protein
AL538_RS10280	COG2165	general secretion pathway protein
AL538_RS10285	COG4795	General secretion pathway protein
AL538_RS10290	COG3156	type II secretion system protein K
AL538_RS10295	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL538_RS10300	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL538_RS10310	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL538_RS10315	COG0494	nUDIX hydrolase
AL538_RS10325	COG1040	competence protein
AL538_RS10340	COG2183	response to ionizing radiation
AL538_RS10350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL538_RS10365	COG2233	PERMEase
AL538_RS10375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL538_RS10380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL538_RS10385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL538_RS10390	COG1758	RNA polymerase activity
AL538_RS10395	COG0194	GDP metabolic process
AL538_RS10410	COG0848	biopolymer transport protein
AL538_RS10415	COG0811	peptide transport
AL538_RS10435	COG4174	ABC transporter (Permease)
AL538_RS10440	COG4239	(ABC) transporter, permease
AL538_RS10445	COG0747	negative chemotaxis
AL538_RS10450	COG0444	Belongs to the ABC transporter superfamily
AL538_RS10455	COG4608	Belongs to the ABC transporter superfamily
AL538_RS10480	COG0745	RESPONSE REGULATOR receiver
AL538_RS10485	COG1561	YicC-like family, N-terminal region
AL538_RS10490	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL538_RS10495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL538_RS10500	COG1560	Kdo2-lipid A biosynthetic process
AL538_RS10510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL538_RS10515	COG0840	transmembrane signaling receptor activity
AL538_RS10535	COG2194	sulfuric ester hydrolase activity
AL538_RS10550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL538_RS10565	COG0463	Glycosyl transferase, family 2
AL538_RS10570	COG0859	PFAM glycosyl transferase family 9
AL538_RS10575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL538_RS10580	COG3642	lipopolysaccharide core region biosynthetic process
AL538_RS10590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AL538_RS10620	COG1519	Transferase
AL538_RS10625	COG0859	PFAM glycosyl transferase family 9
AL538_RS10635	COG1560	Kdo2-lipid A biosynthetic process
AL538_RS10645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL538_RS10685	COG4750	Nucleotidyl transferase
AL538_RS10695	COG3475	LICD family
AL538_RS10705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL538_RS10730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL538_RS10740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL538_RS10745	COG0149	triose-phosphate isomerase activity
AL538_RS10770	COG1494	fructose-1,6-bisphosphatase
AL538_RS10780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL538_RS10785	COG1575	Belongs to the MenA family. Type 1 subfamily
AL538_RS10805	COG1609	Transcriptional regulator
AL538_RS10810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL538_RS10815	COG0254	rRNA binding
AL538_RS10830	COG0088	Forms part of the polypeptide exit tunnel
AL538_RS10850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL538_RS10900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL538_RS10915	COG1841	ribosomal large subunit assembly
AL538_RS10920	COG0200	Binds to the 23S rRNA
AL538_RS10925	COG0201	protein transport
AL538_RS10930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL538_RS10935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL538_RS10940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL538_RS10950	COG0202	RNA polymerase activity
AL538_RS10955	COG0203	ribosomal protein L17
AL538_RS10965	COG0545	Peptidyl-prolyl cis-trans isomerase
AL538_RS10980	COG2153	protein acetylation
AL538_RS10985	COG0513	Belongs to the DEAD box helicase family
AL538_RS10995	COG0737	Belongs to the 5'-nucleotidase family
AL538_RS11000	COG1648	precorrin-2 dehydrogenase activity
AL538_RS11000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL538_RS11015	COG0471	metal ion transport
AL538_RS11015	COG3273	potassium ion transport
AL538_RS11020	COG0529	Catalyzes the synthesis of activated sulfate
AL538_RS11040	COG1136	(ABC) transporter
AL538_RS11050	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL538_RS11060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL538_RS11065	COG0729	surface antigen
AL538_RS11075	COG2105	PFAM AIG2 family protein
AL538_RS11085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL538_RS11095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL538_RS11100	COG0163	prenyltransferase activity
AL538_RS11105	COG4143	(ABC) transporter
AL538_RS11110	COG1178	ABC-type Fe3 transport system permease component
AL538_RS11115	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL538_RS11150	COG0142	geranyltranstransferase activity
AL538_RS11155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL538_RS11165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL538_RS11170	COG2966	Psort location CytoplasmicMembrane, score
AL538_RS11175	COG3610	response to peptide
AL538_RS11195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL538_RS11200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL538_RS11205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL538_RS11210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL538_RS11215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL538_RS11235	COG0473	3-isopropylmalate dehydrogenase activity
AL538_RS11240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL538_RS11250	COG0671	phosphoesterase, PA-phosphatase related
AL538_RS11260	COG0583	DNA-binding transcription factor activity
AL538_RS11265	COG1022	Amp-dependent synthetase and ligase
AL538_RS11270	COG0028	Belongs to the TPP enzyme family
AL538_RS11275	COG0440	acetolactate synthase activity
AL538_RS11280	COG3706	GGDEF domain
AL538_RS11290	COG0469	pyruvate kinase activity
AL538_RS11295	COG1349	DNA-binding transcription factor activity
AL538_RS11300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL538_RS11320	COG5002	protein histidine kinase activity
AL538_RS11325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL538_RS11330	COG3722	fumarate hydratase activity
AL538_RS11340	COG2213	PTS system mannitol-specific
AL538_RS11340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS11375	COG0358	DNA primase activity
AL538_RS11380	COG1610	YqeY-like protein
AL538_RS11385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL538_RS11390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL538_RS11395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL538_RS11405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL538_RS11410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL538_RS11425	COG3267	Type II secretory pathway component ExeA
AL538_RS11425	COG3409	Peptidoglycan-binding domain 1 protein
AL538_RS11435	COG4991	sh3 domain protein
AL538_RS11440	COG0306	phosphate transporter
AL538_RS11445	COG1392	Phosphate transport regulator
AL538_RS11450	COG3025	triphosphatase activity
AL538_RS11455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL538_RS11465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL538_RS11475	COG1538	Outer membrane efflux protein
AL538_RS11480	COG0494	nUDIX hydrolase
AL538_RS11485	COG3151	Protein conserved in bacteria
AL538_RS11495	COG3150	esterase
AL538_RS11505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL538_RS11510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL538_RS11525	COG3105	Protein conserved in bacteria
AL538_RS11530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL538_RS11545	COG0723	plastoquinol--plastocyanin reductase activity
AL538_RS11550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL538_RS11555	COG2857	Cytochrome c1
AL538_RS11560	COG0625	glutathione transferase activity
AL538_RS11565	COG2969	positive regulation of protein catabolic process
AL538_RS11570	COG2823	Periplasmic or secreted lipoprotein
AL538_RS11575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL538_RS11590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL538_RS11605	COG3116	cell division
AL538_RS11610	COG0768	penicillin binding
AL538_RS11615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL538_RS11620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL538_RS11635	COG0772	Belongs to the SEDS family
AL538_RS11650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL538_RS11655	COG0849	cell division
AL538_RS11660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL538_RS11675	COG0494	nUDIX hydrolase
AL538_RS11685	COG0505	Belongs to the CarA family
AL538_RS11690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL538_RS11710	COG0730	response to heat
AL538_RS11715	COG0583	DNA-binding transcription factor activity
AL538_RS11720	COG2860	membrane
AL538_RS11745	COG0493	'glutamate synthase
AL538_RS11750	COG0070	glutamate synthase
AL538_RS11750	COG0067	glutamate synthase
AL538_RS11750	COG0069	glutamate synthase activity
AL538_RS11760	COG0067	glutamate synthase
AL538_RS11760	COG0069	glutamate synthase activity
AL538_RS11760	COG0070	glutamate synthase
AL538_RS11765	COG1242	4 iron, 4 sulfur cluster binding
AL538_RS11770	COG4251	negative regulation of phosphorylation
AL538_RS11770	COG3706	GGDEF domain
AL538_RS11770	COG2203	Gaf domain
AL538_RS11770	COG5001	Diguanylate cyclase
AL538_RS11780	COG0784	Response regulator, receiver
AL538_RS11780	COG2198	Histidine kinase
AL538_RS11780	COG5002	protein histidine kinase activity
AL538_RS11790	COG0745	RESPONSE REGULATOR receiver
AL538_RS11800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL538_RS11815	COG0083	homoserine kinase activity
AL538_RS11820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL538_RS11825	COG0431	NADPH-dependent FMN reductase
AL538_RS11855	COG1115	amino acid carrier protein
AL538_RS11860	COG3022	response to hydroperoxide
AL538_RS11870	COG0513	Belongs to the DEAD box helicase family
AL538_RS11885	COG0716	FMN binding
AL538_RS11890	COG4974	Belongs to the 'phage' integrase family
AL538_RS11895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL538_RS11900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL538_RS11905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL538_RS11925	COG0667	Aldo Keto reductase
AL538_RS11945	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AL538_RS11950	COG0730	response to heat
AL538_RS11965	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL538_RS11970	COG0583	DNA-binding transcription factor activity
AL538_RS11975	COG0640	Transcriptional regulator
AL538_RS11980	COG0268	Binds directly to 16S ribosomal RNA
AL538_RS11985	COG0728	peptidoglycan biosynthetic process
AL538_RS11990	COG0196	riboflavin kinase activity
AL538_RS12005	COG1047	Peptidyl-prolyl cis-trans
AL538_RS12010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL538_RS12015	COG3279	Response regulator of the LytR AlgR family
AL538_RS12020	COG3275	phosphorelay sensor kinase activity
AL538_RS12025	COG1966	Carbon starvation protein
AL538_RS12045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL538_RS12055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL538_RS12060	COG1605	Chorismate mutase
AL538_RS12060	COG0287	Prephenate dehydrogenase
AL538_RS12065	COG0739	heme binding
AL538_RS12075	COG0488	(ABC) transporter
AL538_RS12090	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL538_RS12095	COG1605	Chorismate mutase
AL538_RS12095	COG0077	Prephenate dehydratase
AL538_RS12100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL538_RS12105	COG0741	lytic transglycosylase activity
AL538_RS12110	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL538_RS12115	COG0564	pseudouridine synthase activity
AL538_RS12120	COG1496	oxidoreductase activity
AL538_RS12125	COG0542	response to heat
AL538_RS12180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL538_RS12185	COG0826	peptidase U32
AL538_RS12195	COG0745	RESPONSE REGULATOR receiver
AL538_RS12200	COG5002	protein histidine kinase activity
AL538_RS12210	COG0248	Ppx GppA phosphatase
AL538_RS12215	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL538_RS12220	COG0573	inorganic phosphate transmembrane transporter activity
AL538_RS12225	COG0581	inorganic phosphate transmembrane transporter activity
AL538_RS12230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL538_RS12235	COG0704	Plays a role in the regulation of phosphate uptake
AL538_RS12265	COG0450	alkyl hydroperoxide reductase
AL538_RS12270	COG0583	DNA-binding transcription factor activity
AL538_RS12275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL538_RS12285	COG0517	IMP dehydrogenase activity
AL538_RS12310	COG1862	Preprotein translocase
AL538_RS12315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL538_RS12320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL538_RS12335	COG0483	inositol monophosphate 1-phosphatase activity
AL538_RS12340	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL538_RS12355	COG0822	iron-sulfur transferase activity
AL538_RS12360	COG0316	Belongs to the HesB IscA family
AL538_RS12375	COG0633	Ferredoxin
AL538_RS12380	COG2975	iron-sulfur cluster assembly
AL538_RS12415	COG2976	Protein conserved in bacteria
AL538_RS12420	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL538_RS12435	COG2199	diguanylate cyclase activity
AL538_RS12435	COG2203	Gaf domain
AL538_RS12445	COG0516	GMP reductase activity
AL538_RS12445	COG0517	IMP dehydrogenase activity
AL538_RS12455	COG1757	Na H antiporter
AL538_RS12465	COG1584	GPR1 FUN34 yaaH family protein
AL538_RS12470	COG1115	amino acid carrier protein
AL538_RS12480	COG0583	DNA-binding transcription factor activity
AL538_RS12495	COG2873	o-acetylhomoserine
AL538_RS12500	COG0316	Belongs to the HesB IscA family
AL538_RS12505	COG0719	Fe-S assembly protein
AL538_RS12510	COG0396	ATPase activity
AL538_RS12515	COG0719	Fe-S assembly protein
AL538_RS12535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL538_RS12555	COG1289	transmembrane transporter activity
AL538_RS12560	COG0583	DNA-binding transcription factor activity
AL538_RS12615	COG2003	Belongs to the UPF0758 family
AL538_RS12675	COG0582	viral genome integration into host DNA
AL538_RS12690	COG2867	negative regulation of translational initiation
AL538_RS12695	COG2914	Belongs to the UPF0125 (RnfH) family
AL538_RS12700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL538_RS12705	COG0497	DNA recombination
AL538_RS12725	COG1301	dicarboxylic acid transport
AL538_RS12745	COG4969	Belongs to the N-Me-Phe pilin family
AL538_RS12765	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL538_RS12770	COG0590	tRNA wobble adenosine to inosine editing
AL538_RS12780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL538_RS12780	COG0047	phosphoribosylformylglycinamidine synthase activity
AL538_RS12810	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL538_RS12815	COG2252	PERMEase
AL538_RS12820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL538_RS12825	COG1073	alpha beta
AL538_RS12840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL538_RS12845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL538_RS12850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL538_RS12850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL538_RS12875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL538_RS12880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL538_RS12890	COG0142	geranyltranstransferase activity
AL538_RS12900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL538_RS12915	COG0583	DNA-binding transcription factor activity
AL538_RS12925	COG2363	Small membrane protein
AL538_RS12945	COG1611	Belongs to the LOG family
AL538_RS12970	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL538_RS12975	COG0737	Belongs to the 5'-nucleotidase family
AL538_RS12985	COG1464	Belongs to the NlpA lipoprotein family
AL538_RS12990	COG2011	ABC-type metal ion transport system permease component
AL538_RS12995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL538_RS13000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL538_RS13010	COG1263	PTS System
AL538_RS13010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS13015	COG0366	Alpha amylase catalytic
AL538_RS13030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL538_RS13035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL538_RS13055	COG1686	Belongs to the peptidase S11 family
AL538_RS13060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL538_RS13065	COG0772	Belongs to the SEDS family
AL538_RS13080	COG0799	negative regulation of ribosome biogenesis
AL538_RS13085	COG1466	dna polymerase III delta subunit
AL538_RS13090	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL538_RS13100	COG2888	peptidyl-tyrosine sulfation
AL538_RS13105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL538_RS13110	COG4535	Mg2 and Co2 transporter CorC
AL538_RS13120	COG1702	phosphate starvation-inducible protein PhoH
AL538_RS13130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL538_RS13250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL538_RS13275	COG2890	protein-(glutamine-N5) methyltransferase activity
AL538_RS13280	COG3094	Invasion gene expression up-regulator, SirB
AL538_RS13285	COG2912	Transglutaminase-like superfamily
AL538_RS13290	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL538_RS13295	COG0737	Belongs to the 5'-nucleotidase family
AL538_RS13300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL538_RS13305	COG1187	pseudouridine synthase activity
AL538_RS13310	COG2840	Smr protein MutS2
AL538_RS13350	COG2608	mercury ion transmembrane transporter activity
AL538_RS13350	COG2217	Heavy metal translocating P-type atpase
AL538_RS13360	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL538_RS13425	COG0784	Response regulator, receiver
AL538_RS13425	COG0835	chemotaxis
AL538_RS13430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL538_RS13435	COG1815	bacterial-type flagellum-dependent cell motility
AL538_RS13440	COG1558	bacterial-type flagellum-dependent cell motility
AL538_RS13455	COG4787	bacterial-type flagellum-dependent cell motility
AL538_RS13465	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL538_RS13470	COG1706	bacterial-type flagellum-dependent cell motility
AL538_RS13490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS13495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS13500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS13505	COG2190	(PTS) system
AL538_RS13510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL538_RS13515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS13520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL538_RS13525	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL538_RS13555	COG0330	HflC and HflK could
AL538_RS13560	COG3118	belongs to the thioredoxin family
AL538_RS13565	COG0300	oxidoreductase activity
AL538_RS13570	COG1090	epimerase
AL538_RS13600	COG0622	Phosphoesterase
AL538_RS13620	COG3710	Transcriptional regulator
AL538_RS13635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL538_RS13640	COG3104	oligopeptide transport
AL538_RS13650	COG0367	asparagine synthase
AL538_RS13655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL538_RS13655	COG4651	solute:proton antiporter activity
AL538_RS13660	COG1846	Transcriptional regulator
AL538_RS13660	COG1940	carbohydrate kinase activity
AL538_RS13665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL538_RS13670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS13670	COG2190	(PTS) system
AL538_RS13670	COG1263	PTS System
AL538_RS13680	COG2165	general secretion pathway protein
AL538_RS13685	COG0735	belongs to the Fur family
AL538_RS13695	COG0716	FMN binding
AL538_RS13705	COG0596	Alpha beta hydrolase
AL538_RS13710	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL538_RS13715	COG0033	Phosphoglucomutase
AL538_RS13730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL538_RS13745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL538_RS13750	COG1053	succinate dehydrogenase
AL538_RS13760	COG0567	Dehydrogenase, E1 component
AL538_RS13765	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL538_RS13780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL538_RS13785	COG1121	(ABC) transporter
AL538_RS13790	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL538_RS13795	COG4977	sequence-specific DNA binding
AL538_RS13800	COG1918	ferrous iron import across plasma membrane
AL538_RS13830	COG3102	Protein conserved in bacteria
AL538_RS13835	COG0788	formyltetrahydrofolate deformylase activity
AL538_RS13840	COG1199	ATP-dependent helicase activity
AL538_RS13845	COG1214	PFAM Peptidase M22, glycoprotease
AL538_RS13855	COG3065	identical protein binding
AL538_RS13860	COG2267	carboxylic ester hydrolase activity
AL538_RS13865	COG0318	PFAM AMP-dependent synthetase and ligase
AL538_RS13870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL538_RS13875	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL538_RS13880	COG2894	cell division
AL538_RS13895	COG2951	lytic endotransglycosylase activity
AL538_RS13905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL538_RS13965	COG1715	Restriction endonuclease
AL538_RS13970	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL538_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS14070	COG2986	histidine ammonia-lyase
AL538_RS14075	COG1216	Glycosyl transferase, family 2
AL538_RS14095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL538_RS14100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL538_RS14140	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS14150	COG1169	isochorismate synthase
AL538_RS14155	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL538_RS14160	COG3433	isochorismatase activity
AL538_RS14160	COG1535	isochorismatase
AL538_RS14165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL538_RS14165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL538_RS14180	COG4771	TonB-dependent receptor
AL538_RS14185	COG1253	flavin adenine dinucleotide binding
AL538_RS14190	COG0513	Belongs to the DEAD box helicase family
AL538_RS14195	COG0569	domain protein
AL538_RS14200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL538_RS14215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL538_RS14220	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL538_RS14225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL538_RS14240	COG4191	Histidine kinase
AL538_RS14260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL538_RS14265	COG0776	regulation of translation
AL538_RS14270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL538_RS14295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL538_RS14300	COG0436	Aminotransferase
AL538_RS14305	COG1169	isochorismate synthase
AL538_RS14315	COG0596	Alpha beta hydrolase
AL538_RS14320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL538_RS14335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS14335	COG2190	(PTS) system
AL538_RS14335	COG1263	PTS System
AL538_RS14340	COG0583	DNA-binding transcription factor activity
AL538_RS14350	COG2855	membrane
AL538_RS14355	COG0477	Major facilitator Superfamily
AL538_RS14405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS14430	COG1522	sequence-specific DNA binding
AL538_RS14440	COG3385	transposase activity
AL538_RS14445	COG1946	Acyl-CoA thioesterase
AL538_RS14450	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL538_RS14475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AL538_RS14480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL538_RS14485	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL538_RS14490	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AL538_RS14495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL538_RS14495	COG0617	tRNA 3'-terminal CCA addition
AL538_RS14495	COG0517	IMP dehydrogenase activity
AL538_RS14505	COG2217	Heavy metal translocating P-type atpase
AL538_RS14525	COG0537	adenosine 5'-monophosphoramidase activity
AL538_RS14555	COG1252	NADH dehydrogenase
AL538_RS14570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL538_RS14580	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL538_RS14585	COG1136	(ABC) transporter
AL538_RS14590	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL538_RS14605	COG1132	(ABC) transporter
AL538_RS14625	COG2719	SpoVR family
AL538_RS14630	COG2718	Belongs to the UPF0229 family
AL538_RS14635	COG2766	serine protein kinase
AL538_RS14650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL538_RS14660	COG1882	Formate acetyltransferase
AL538_RS14695	COG0708	Exodeoxyribonuclease III
AL538_RS14700	COG0840	transmembrane signaling receptor activity
AL538_RS14715	COG0730	response to heat
AL538_RS14720	COG1199	ATP-dependent helicase activity
AL538_RS14730	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL538_RS14735	COG1187	pseudouridine synthase activity
AL538_RS14745	COG1278	Cold shock
AL538_RS14755	COG0542	response to heat
AL538_RS14760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL538_RS14790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL538_RS14795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL538_RS14800	COG0297	glycogen (starch) synthase activity
AL538_RS14820	COG3070	regulator of competence-specific genes
AL538_RS14835	COG0745	RESPONSE REGULATOR receiver
AL538_RS14840	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL538_RS14845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL538_RS14855	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL538_RS14860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL538_RS14875	COG4067	protein conserved in archaea
AL538_RS14875	COG0189	ligase activity
AL538_RS14890	COG1801	Protein of unknown function DUF72
AL538_RS14905	COG0840	transmembrane signaling receptor activity
AL538_RS14910	COG0632	four-way junction helicase activity
AL538_RS14920	COG1271	oxidase subunit
AL538_RS14925	COG1294	oxidase, subunit
AL538_RS14930	COG4890	Cyd operon protein YbgT
AL538_RS14940	COG0824	Thioesterase
AL538_RS14945	COG0811	peptide transport
AL538_RS14960	COG0823	Involved in the tonB-independent uptake of proteins
AL538_RS14965	COG2885	chlorophyll binding
AL538_RS14970	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL538_RS14985	COG0673	inositol 2-dehydrogenase activity
AL538_RS14990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS14990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL538_RS14990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS14995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS15000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS15005	COG1882	Formate acetyltransferase
AL538_RS15010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL538_RS15020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL538_RS15025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS15030	COG2207	Transcriptional regulator
AL538_RS15035	COG0371	Dehydrogenase
AL538_RS15040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL538_RS15060	COG3766	membrane
AL538_RS15070	COG0754	glutathionylspermidine amidase activity
AL538_RS15080	COG5002	protein histidine kinase activity
AL538_RS15080	COG0784	Response regulator, receiver
AL538_RS15160	COG4669	(LipO)protein
AL538_RS15205	COG4792	protein secretion
AL538_RS15210	COG4791	protein targeting
AL538_RS15215	COG4794	Type iii secretion
AL538_RS15220	COG4790	Type iii secretion
AL538_RS15290	COG0457	Tetratricopeptide repeat
AL538_RS15305	COG0789	Transcriptional regulator
AL538_RS15310	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL538_RS15325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS15325	COG1263	PTS System
AL538_RS15330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS15335	COG1621	beta-fructofuranosidase activity
AL538_RS15340	COG2824	Alkylphosphonate utilization operon protein PhnA
AL538_RS15355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL538_RS15380	COG0534	Mate efflux family protein
AL538_RS15385	COG0444	Belongs to the ABC transporter superfamily
AL538_RS15390	COG4608	Belongs to the ABC transporter superfamily
AL538_RS15395	COG0747	negative chemotaxis
AL538_RS15415	COG0583	DNA-binding transcription factor activity
AL538_RS15420	COG4771	TonB-dependent receptor
AL538_RS15440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS15445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS15455	COG2186	Transcriptional regulator
AL538_RS15465	COG1288	antiporter activity
AL538_RS15490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS15505	COG2176	DNA-directed DNA polymerase activity
AL538_RS15510	COG0517	IMP dehydrogenase activity
AL538_RS15515	COG2186	Transcriptional regulator
AL538_RS15520	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS15525	COG2186	Transcriptional regulator
AL538_RS15545	COG1917	Cupin 2, conserved barrel domain protein
AL538_RS15550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS15555	COG0800	Aldolase
AL538_RS15560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS15570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL538_RS15600	COG3568	Endonuclease Exonuclease Phosphatase
AL538_RS15610	COG4934	collagen metabolic process
AL538_RS15645	COG0686	Belongs to the AlaDH PNT family
AL538_RS15655	COG1674	ftsk spoiiie
AL538_RS15665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL538_RS15685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL538_RS15690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL538_RS15725	COG0300	oxidoreductase activity
AL538_RS15740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL538_RS15750	COG2268	Band 7 protein
AL538_RS15760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL538_RS15770	COG0482	sulfurtransferase activity
AL538_RS15780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS15790	COG1757	Na H antiporter
AL538_RS15805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL538_RS15810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL538_RS15815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL538_RS15815	COG0131	Imidazoleglycerol-phosphate dehydratase
AL538_RS15820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL538_RS15825	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL538_RS15835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL538_RS15835	COG0140	phosphoribosyl-ATP diphosphatase activity
AL538_RS15840	COG3012	SEC-C Motif Domain Protein
AL538_RS15845	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL538_RS15850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL538_RS15855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL538_RS15860	COG0215	cysteine-tRNA ligase activity
AL538_RS15865	COG1435	thymidine kinase activity
AL538_RS15870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL538_RS15895	COG2116	formate transmembrane transporter activity
AL538_RS15900	COG0390	transport system, permease component
AL538_RS15905	COG4459	periplasmic nitrate reductase
AL538_RS15910	COG3005	denitrification pathway
AL538_RS15915	COG0243	molybdopterin cofactor binding
AL538_RS15930	COG1121	(ABC) transporter
AL538_RS15935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL538_RS15940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL538_RS15945	COG1227	inorganic diphosphatase activity
AL538_RS15955	COG4172	Belongs to the ABC transporter superfamily
AL538_RS15965	COG4171	peptide transport system, permease
AL538_RS15980	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL538_RS15985	COG1842	Phage shock protein A
AL538_RS16015	COG2818	Glycosylase
AL538_RS16020	COG5380	lipid catabolic process
AL538_RS16025	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL538_RS16030	COG0626	cystathionine gamma-synthase activity
AL538_RS16040	COG0733	neurotransmitter:sodium symporter activity
AL538_RS16050	COG0564	pseudouridine synthase activity
AL538_RS16060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL538_RS16065	COG1151	hydroxylamine reductase activity
AL538_RS16070	COG3604	Transcriptional regulator
AL538_RS16075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL538_RS16080	COG4136	ATPase activity
AL538_RS16085	COG4135	transport system, permease component
AL538_RS16090	COG4134	Bacterial extracellular solute-binding protein
AL538_RS16095	COG0398	Pfam SNARE associated Golgi protein
AL538_RS16105	COG0493	'glutamate synthase
AL538_RS16130	COG0659	secondary active sulfate transmembrane transporter activity
AL538_RS16140	COG3313	Fe-S protein
AL538_RS16195	COG1061	Type III restriction enzyme res subunit
AL538_RS16200	COG1187	pseudouridine synthase activity
AL538_RS16205	COG2814	Major facilitator Superfamily
AL538_RS16215	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS16225	COG1609	Transcriptional regulator
AL538_RS16230	COG0702	epimerase
AL538_RS16240	COG4181	ATPase activity
AL538_RS16270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL538_RS16280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL538_RS16290	COG1737	Transcriptional regulator
AL538_RS16295	COG0076	glutamate decarboxylase activity
AL538_RS16305	COG2431	L-lysine efflux transmembrane transporter activity
AL538_RS16315	COG3070	regulator of competence-specific genes
AL538_RS16330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS16330	COG4191	Histidine kinase
AL538_RS16340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL538_RS16350	COG5002	protein histidine kinase activity
AL538_RS16350	COG3447	MASE1 domain protein
AL538_RS16350	COG5001	Diguanylate cyclase
AL538_RS16370	COG0583	DNA-binding transcription factor activity
AL538_RS16375	COG2610	gluconate transmembrane transporter activity
AL538_RS16385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL538_RS16390	COG4988	ABC transporter
AL538_RS16395	COG0492	ferredoxin-NADP+ reductase activity
AL538_RS16415	COG3706	GGDEF domain
AL538_RS16420	COG0471	metal ion transport
AL538_RS16425	COG2949	membrane
AL538_RS16435	COG1643	Atp-dependent helicase
AL538_RS16475	COG0471	metal ion transport
AL538_RS16480	COG4191	Histidine kinase
AL538_RS16480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS16490	COG5001	Diguanylate cyclase
AL538_RS16490	COG3300	MHYT domain
AL538_RS16500	COG1280	lysine exporter protein (LysE YggA)
AL538_RS16505	COG1328	CTP reductase activity
AL538_RS16510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL538_RS16520	COG0861	Integral membrane protein TerC family
AL538_RS16530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL538_RS16540	COG3706	GGDEF domain
AL538_RS16550	COG1454	alcohol dehydrogenase
AL538_RS16555	COG0814	amino acid
AL538_RS16570	COG1120	ATPase activity
AL538_RS16575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL538_RS16580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL538_RS16585	COG4774	siderophore transport
AL538_RS16600	COG1132	(ABC) transporter
AL538_RS16605	COG1132	(ABC) transporter
AL538_RS16610	COG2165	general secretion pathway protein
AL538_RS16620	COG0583	DNA-binding transcription factor activity
AL538_RS16645	COG0443	Heat shock 70 kDa protein
AL538_RS16650	COG0443	Heat shock 70 kDa protein
AL538_RS16660	COG3706	GGDEF domain
AL538_RS16690	COG0243	molybdopterin cofactor binding
AL538_RS16695	COG0437	4 iron, 4 sulfur cluster binding
AL538_RS16700	COG3302	dmso reductase anchor subunit
AL538_RS16715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL538_RS16720	COG1643	Atp-dependent helicase
AL538_RS16745	COG3063	Type IV pilus biogenesis stability protein PilW
AL538_RS16770	COG0531	amino acid
AL538_RS16775	COG1280	lysine exporter protein (LysE YggA)
AL538_RS16780	COG0583	DNA-binding transcription factor activity
AL538_RS16785	COG1560	Kdo2-lipid A biosynthetic process
AL538_RS16800	COG1846	Transcriptional regulator
AL538_RS16810	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL538_RS16815	COG2197	response regulator
AL538_RS16850	COG1280	lysine exporter protein (LysE YggA)
AL538_RS16865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS16870	COG2358	TRAP transporter, solute receptor (TAXI family
AL538_RS16875	COG0730	response to heat
AL538_RS16900	COG0456	acetyltransferase
AL538_RS16910	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL538_RS17020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL538_RS17025	COG0372	Belongs to the citrate synthase family
AL538_RS17035	COG2828	Protein conserved in bacteria
AL538_RS17060	COG0561	phosphatase activity
AL538_RS17065	COG0602	queuosine metabolic process
AL538_RS17075	COG2199	diguanylate cyclase activity
AL538_RS17075	COG2203	Gaf domain
AL538_RS17115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL538_RS17125	COG0297	glycogen (starch) synthase activity
AL538_RS18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS18215	COG4999	Histidine kinase
AL538_RS18215	COG3850	Histidine kinase
AL538_RS18215	COG3437	response regulator, receiver
AL538_RS18215	COG2205	protein histidine kinase activity
AL538_RS18235	COG0110	maltose O-acetyltransferase activity
AL538_RS18865	COG0601	transmembrane transport
AL538_RS18950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS19380	COG2986	histidine ammonia-lyase
AL538_RS20325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL538_RS20345	COG0134	indole-3-glycerol-phosphate synthase activity
AL538_RS20345	COG0135	phosphoribosylanthranilate isomerase activity
AL538_RS20350	COG0135	phosphoribosylanthranilate isomerase activity
AL538_RS20350	COG0134	indole-3-glycerol-phosphate synthase activity
AL538_RS20450	COG1032	radical SAM domain protein
AL538_RS20910	COG1530	ribonuclease E activity
AL538_RS21055	COG0857	belongs to the CobB CobQ family
AL538_RS21055	COG0280	phosphate acetyltransferase
AL538_RS21165	COG4656	Part of a membrane complex involved in electron transport
AL538_RS21355	COG0581	inorganic phosphate transmembrane transporter activity
AL538_RS21610	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL538_RS21610	COG1902	pentaerythritol trinitrate reductase activity
AL538_RS21675	COG1785	Belongs to the alkaline phosphatase family
AL538_RS21745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL538_RS21930	COG1138	Cytochrome C-type biogenesis protein
AL538_RS22065	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL538_RS22110	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL538_RS22230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL538_RS22265	COG1960	acyl-CoA dehydrogenase activity
AL538_RS22570	COG0514	ATP-dependent DNA helicase (RecQ)
AL538_RS22695	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL538_RS23050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL538_RS23615	COG0668	transmembrane transport
AL538_RS23645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL538_RS23730	COG1194	a g-specific adenine glycosylase
AL538_RS24050	COG3164	Protein of unknown function
AL538_RS24465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL538_RS24590	COG0488	(ABC) transporter
AL538_RS24630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL538_RS25005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS25040	COG2814	Major facilitator Superfamily
AL538_RS25150	COG1982	Orn Lys Arg decarboxylase major
AL538_RS25310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL538_RS25440	COG1309	transcriptional regulator
AL538_RS25560	COG3148	PFAM DTW domain containing protein
AL538_RS25805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL538_RS25900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL538_RS26050	COG1475	DNA binding
AL538_RS26070	COG0445	tRNA wobble uridine modification
AL538_RS26275	COG0210	DNA helicase
AL538_RS26295	COG0444	Belongs to the ABC transporter superfamily
AL538_RS26400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL538_RS26415	COG0339	signal peptide processing
AL538_RS26560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL538_RS26560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL538_RS26565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL538_RS26565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL538_RS26625	COG0174	glutamine synthetase
AL538_RS26795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL538_RS26960	COG2194	sulfuric ester hydrolase activity
AL538_RS26990	COG0859	PFAM glycosyl transferase family 9