locus-tag	class	description
AL538_RS00010	COG2204	response regulator
AL538_RS00030	COG2885	chlorophyll binding
AL538_RS00040	COG1793	dna ligase
AL538_RS00050	COG0534	Mate efflux family protein
AL538_RS00055	COG0307	riboflavin synthase, alpha
AL538_RS00065	COG3001	Fructosamine kinase
AL538_RS00070	COG2201	protein-glutamate methylesterase activity
AL538_RS00075	COG3706	GGDEF domain
AL538_RS00085	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL538_RS00110	COG0840	transmembrane signaling receptor activity
AL538_RS00120	COG0840	transmembrane signaling receptor activity
AL538_RS00165	COG1454	alcohol dehydrogenase
AL538_RS00180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL538_RS00185	COG1063	alcohol dehydrogenase
AL538_RS00195	COG3119	arylsulfatase activity
AL538_RS00200	COG0641	radical SAM
AL538_RS00205	COG0714	Associated with various cellular activities
AL538_RS00235	COG2188	Transcriptional regulator
AL538_RS00275	COG2003	Belongs to the UPF0758 family
AL538_RS00310	COG1203	CRISPR-associated helicase, Cas3
AL538_RS00340	COG1518	maintenance of DNA repeat elements
AL538_RS00345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL538_RS00405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL538_RS00435	COG3710	Transcriptional regulator
AL538_RS00450	COG4790	Type iii secretion
AL538_RS00515	COG0791	NLP P60 protein
AL538_RS00520	COG0840	transmembrane signaling receptor activity
AL538_RS00525	COG3385	transposase activity
AL538_RS00565	COG3148	PFAM DTW domain containing protein
AL538_RS00570	COG1940	carbohydrate kinase activity
AL538_RS00580	COG0303	'Molybdopterin
AL538_RS00590	COG3842	ATPase activity
AL538_RS00595	COG4662	Binding-protein-dependent transport system inner membrane component
AL538_RS00605	COG2204	response regulator
AL538_RS00610	COG4191	Histidine kinase
AL538_RS00630	COG0488	(ABC) transporter
AL538_RS00635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL538_RS00655	COG3381	protein complex oligomerization
AL538_RS00665	COG3383	formate dehydrogenase (NAD+) activity
AL538_RS00665	COG0243	molybdopterin cofactor binding
AL538_RS00670	COG0437	4 iron, 4 sulfur cluster binding
AL538_RS00690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL538_RS00695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL538_RS00705	COG1177	transmembrane transport
AL538_RS00715	COG3842	ATPase activity
AL538_RS00725	COG2992	FlgJ-related protein
AL538_RS00740	COG0589	response to stress
AL538_RS00745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL538_RS00760	COG2217	Heavy metal translocating P-type atpase
AL538_RS00770	COG2010	Cytochrome c
AL538_RS00785	COG3278	Belongs to the heme-copper respiratory oxidase family
AL538_RS00800	COG2205	protein histidine kinase activity
AL538_RS00800	COG0784	Response regulator, receiver
AL538_RS00830	COG1067	ATP-dependent peptidase activity
AL538_RS00835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL538_RS00850	COG0488	(ABC) transporter
AL538_RS00875	COG2902	Dehydrogenase
AL538_RS00885	COG0308	aminopeptidase N
AL538_RS00900	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL538_RS00905	COG1956	GAF domain-containing protein
AL538_RS00910	COG1132	(ABC) transporter
AL538_RS00915	COG2995	paraquat-inducible protein a
AL538_RS00920	COG3008	intermembrane lipid transfer
AL538_RS00945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL538_RS00965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS00970	COG4597	amino acid ABC transporter
AL538_RS00975	COG0765	amino acid transport
AL538_RS00980	COG1126	abc transporter atp-binding protein
AL538_RS00985	COG0670	Belongs to the BI1 family
AL538_RS00990	COG2920	part of a sulfur-relay system
AL538_RS00995	COG1254	Belongs to the acylphosphatase family
AL538_RS01035	COG3300	MHYT domain
AL538_RS01035	COG5001	Diguanylate cyclase
AL538_RS01040	COG2205	protein histidine kinase activity
AL538_RS01040	COG3437	response regulator, receiver
AL538_RS01040	COG3850	Histidine kinase
AL538_RS01040	COG4999	Histidine kinase
AL538_RS01055	COG0110	maltose O-acetyltransferase activity
AL538_RS01080	COG1846	Transcriptional regulator
AL538_RS01090	COG3247	response to pH
AL538_RS01095	COG0668	transmembrane transport
AL538_RS01105	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL538_RS01165	COG4964	Belongs to the GSP D family
AL538_RS01190	COG2207	Transcriptional regulator
AL538_RS01210	COG0589	response to stress
AL538_RS01215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL538_RS01220	COG0363	glucosamine-6-phosphate deaminase activity
AL538_RS01225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL538_RS01235	COG4774	siderophore transport
AL538_RS01240	COG4565	transcriptional regulatory protein
AL538_RS01245	COG3290	protein histidine kinase activity
AL538_RS01260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS01290	COG0583	DNA-binding transcription factor activity
AL538_RS01305	COG3005	denitrification pathway
AL538_RS01320	COG1999	signal sequence binding
AL538_RS01325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL538_RS01345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL538_RS01375	COG2186	Transcriptional regulator
AL538_RS01390	COG0702	epimerase
AL538_RS01395	COG0583	DNA-binding transcription factor activity
AL538_RS01400	COG1404	Belongs to the peptidase S8 family
AL538_RS01405	COG1858	cytochrome C peroxidase
AL538_RS01415	COG0527	aspartate kinase activity
AL538_RS01420	COG0662	Cupin 2, conserved barrel domain protein
AL538_RS01425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL538_RS01430	COG0456	acetyltransferase
AL538_RS01435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL538_RS01445	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AL538_RS01450	COG0534	Mate efflux family protein
AL538_RS01465	COG1368	sulfuric ester hydrolase activity
AL538_RS01500	COG1115	amino acid carrier protein
AL538_RS01505	COG1012	belongs to the aldehyde dehydrogenase family
AL538_RS01510	COG3284	Transcriptional regulator
AL538_RS01540	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AL538_RS01550	COG3051	citrate lyase alpha subunit
AL538_RS01555	COG2301	Belongs to the HpcH HpaI aldolase family
AL538_RS01565	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AL538_RS01575	COG3630	sodium ion export across plasma membrane
AL538_RS01580	COG5016	pyruvate
AL538_RS01580	COG0511	ligase activity, forming carbon-carbon bonds
AL538_RS01585	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL538_RS01595	COG4565	transcriptional regulatory protein
AL538_RS01635	COG1051	belongs to the nudix hydrolase family
AL538_RS01685	COG0625	glutathione transferase activity
AL538_RS01695	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL538_RS01710	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL538_RS01720	COG0601	transmembrane transport
AL538_RS01725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL538_RS01730	COG0444	Belongs to the ABC transporter superfamily
AL538_RS01750	COG3291	Pkd domain containing protein
AL538_RS01770	COG0745	RESPONSE REGULATOR receiver
AL538_RS01780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS01785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS01805	COG0813	purine-nucleoside phosphorylase activity
AL538_RS01810	COG1177	transmembrane transport
AL538_RS01815	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL538_RS01820	COG3842	ATPase activity
AL538_RS01825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL538_RS01830	COG2423	ornithine cyclodeaminase activity
AL538_RS01845	COG3938	Belongs to the proline racemase family
AL538_RS01875	COG1451	nucleotide metabolic process
AL538_RS01880	COG2165	general secretion pathway protein
AL538_RS01890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS01905	COG0583	DNA-binding transcription factor activity
AL538_RS01965	COG4139	cobalamin transport
AL538_RS01980	COG2062	phosphohistidine phosphatase, SixA
AL538_RS01990	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL538_RS02000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL538_RS02005	COG0702	epimerase
AL538_RS02010	COG1823	symporter activity
AL538_RS02020	COG2925	Exonuclease
AL538_RS02030	COG1346	cytolysis
AL538_RS02095	COG0072	phenylalanine-tRNA ligase activity
AL538_RS02095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL538_RS02105	COG3706	GGDEF domain
AL538_RS02150	COG0251	oxidation-reduction process
AL538_RS02160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL538_RS02185	COG2188	Transcriptional regulator
AL538_RS02195	COG0010	Belongs to the arginase family
AL538_RS02205	COG2986	histidine ammonia-lyase
AL538_RS02220	COG0247	lactate metabolic process
AL538_RS02220	COG0277	FAD linked oxidase domain protein
AL538_RS02255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL538_RS02295	COG0456	acetyltransferase
AL538_RS02665	COG2026	Addiction module toxin, RelE StbE family
AL538_RS02710	COG1403	HNH endonuclease
AL538_RS02740	COG0625	glutathione transferase activity
AL538_RS02760	COG3385	transposase activity
AL538_RS03055	COG3340	Belongs to the peptidase S51 family
AL538_RS03415	COG0110	maltose O-acetyltransferase activity
AL538_RS03440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL538_RS03455	COG3106	COG3106 Predicted ATPase
AL538_RS03470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL538_RS03475	COG2205	protein histidine kinase activity
AL538_RS03475	COG0784	Response regulator, receiver
AL538_RS03490	COG0814	amino acid
AL538_RS03495	COG1760	l-serine dehydratase
AL538_RS03500	COG3300	MHYT domain
AL538_RS03500	COG5001	Diguanylate cyclase
AL538_RS03510	COG2197	response regulator
AL538_RS03515	COG0720	synthase
AL538_RS03520	COG0840	transmembrane signaling receptor activity
AL538_RS03525	COG0017	Asparaginyl-tRNA synthetase
AL538_RS03540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL538_RS03560	COG3437	response regulator, receiver
AL538_RS03560	COG2770	Histidine kinase
AL538_RS03565	COG1448	Aminotransferase
AL538_RS03585	COG0840	transmembrane signaling receptor activity
AL538_RS03590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL538_RS03595	COG1846	Transcriptional regulator
AL538_RS03620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL538_RS03635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL538_RS03640	COG3108	Peptidase M15
AL538_RS03645	COG2989	Protein conserved in bacteria
AL538_RS03670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL538_RS03680	COG4235	cytochrome complex assembly
AL538_RS03680	COG3088	subunit of a heme lyase
AL538_RS03690	COG1138	Cytochrome C-type biogenesis protein
AL538_RS03695	COG3301	Polysulphide reductase, NrfD
AL538_RS03700	COG0437	4 iron, 4 sulfur cluster binding
AL538_RS03710	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL538_RS03730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL538_RS03740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL538_RS03745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL538_RS03770	COG0019	diaminopimelate decarboxylase activity
AL538_RS03815	COG0322	excinuclease ABC activity
AL538_RS03820	COG2197	response regulator
AL538_RS03825	COG0417	DNA replication proofreading
AL538_RS03845	COG1187	pseudouridine synthase activity
AL538_RS03855	COG0009	L-threonylcarbamoyladenylate synthase
AL538_RS03860	COG0613	PHP domain protein
AL538_RS03870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL538_RS03875	COG0512	Glutamine amidotransferase of anthranilate synthase
AL538_RS03885	COG0135	phosphoribosylanthranilate isomerase activity
AL538_RS03885	COG0134	indole-3-glycerol-phosphate synthase activity
AL538_RS03895	COG0159	tryptophan synthase activity
AL538_RS03900	COG1301	dicarboxylic acid transport
AL538_RS03925	COG1607	acyl-coa hydrolase
AL538_RS03930	COG2350	Protein conserved in bacteria
AL538_RS03945	COG0583	DNA-binding transcription factor activity
AL538_RS03960	COG5001	Diguanylate cyclase
AL538_RS03960	COG1716	ATPase activity
AL538_RS03965	COG1032	radical SAM domain protein
AL538_RS03970	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL538_RS03985	COG2964	Protein conserved in bacteria
AL538_RS03990	COG0840	transmembrane signaling receptor activity
AL538_RS04000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL538_RS04005	COG0463	Glycosyl transferase, family 2
AL538_RS04010	COG0745	RESPONSE REGULATOR receiver
AL538_RS04015	COG5002	protein histidine kinase activity
AL538_RS04015	COG3850	Histidine kinase
AL538_RS04050	COG1846	Transcriptional regulator
AL538_RS04065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL538_RS04095	COG0577	efflux transmembrane transporter activity
AL538_RS04095	COG1136	(ABC) transporter
AL538_RS04105	COG0577	efflux transmembrane transporter activity
AL538_RS04130	COG3153	acetyltransferase
AL538_RS04160	COG3118	belongs to the thioredoxin family
AL538_RS04165	COG4232	protein-disulfide reductase activity
AL538_RS04180	COG2995	paraquat-inducible protein a
AL538_RS04185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL538_RS04185	COG3008	intermembrane lipid transfer
AL538_RS04190	COG3009	Protein conserved in bacteria
AL538_RS04245	COG4166	transmembrane transport
AL538_RS04255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL538_RS04260	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL538_RS04270	COG0539	negative regulation of cytoplasmic translation
AL538_RS04280	COG0616	signal peptide processing
AL538_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS04295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS04325	COG0784	Response regulator, receiver
AL538_RS04325	COG0835	chemotaxis
AL538_RS04330	COG1940	carbohydrate kinase activity
AL538_RS04340	COG4667	esterase of the alpha-beta hydrolase superfamily
AL538_RS04355	COG0733	neurotransmitter:sodium symporter activity
AL538_RS04370	COG1263	PTS System
AL538_RS04370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS04375	COG0084	hydrolase, TatD family'
AL538_RS04390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL538_RS04420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL538_RS04435	COG1399	metal-binding, possibly nucleic acid-binding protein
AL538_RS04440	COG0424	maF-like protein
AL538_RS04445	COG0564	pseudouridine synthase activity
AL538_RS04450	COG1530	ribonuclease E activity
AL538_RS04460	COG0659	secondary active sulfate transmembrane transporter activity
AL538_RS04465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL538_RS04470	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL538_RS04500	COG2186	Transcriptional regulator
AL538_RS04510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL538_RS04515	COG0653	protein targeting
AL538_RS04520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL538_RS04525	COG3706	GGDEF domain
AL538_RS04530	COG0366	Alpha amylase catalytic
AL538_RS04535	COG1122	ATPase activity
AL538_RS04540	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL538_RS04565	COG0280	phosphate acetyltransferase
AL538_RS04565	COG0857	belongs to the CobB CobQ family
AL538_RS04570	COG3174	membrane
AL538_RS04575	COG0435	Glutathione S-transferase
AL538_RS04585	COG0444	Belongs to the ABC transporter superfamily
AL538_RS04590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL538_RS04595	COG0601	transmembrane transport
AL538_RS04605	COG0314	molybdopterin synthase activity
AL538_RS04610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL538_RS04620	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL538_RS04625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL538_RS04630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL538_RS04645	COG0556	nucleotide-excision repair
AL538_RS04655	COG1882	Formate acetyltransferase
AL538_RS04660	COG4657	Part of a membrane complex involved in electron transport
AL538_RS04670	COG4656	Part of a membrane complex involved in electron transport
AL538_RS04675	COG4658	electron transport chain
AL538_RS04680	COG4659	FMN binding
AL538_RS04685	COG4660	Part of a membrane complex involved in electron transport
AL538_RS04690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL538_RS04695	COG0346	lactoylglutathione lyase activity
AL538_RS04705	COG2885	chlorophyll binding
AL538_RS04715	COG2056	Na+-H+ antiporter family
AL538_RS04750	COG3451	type IV secretory pathway VirB4
AL538_RS04770	COG3736	Type IV secretory pathway, component VirB8
AL538_RS04775	COG3504	Conjugal transfer protein
AL538_RS04800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL538_RS04805	COG1683	Conserved Protein
AL538_RS04825	COG0583	DNA-binding transcription factor activity
AL538_RS04840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL538_RS04845	COG0581	inorganic phosphate transmembrane transporter activity
AL538_RS04850	COG0573	inorganic phosphate transmembrane transporter activity
AL538_RS04855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL538_RS04940	COG0326	Molecular chaperone. Has ATPase activity
AL538_RS04955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL538_RS04965	COG2003	Belongs to the UPF0758 family
AL538_RS04990	COG2885	chlorophyll binding
AL538_RS04990	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AL538_RS05050	COG4974	Belongs to the 'phage' integrase family
AL538_RS05055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL538_RS05075	COG1454	alcohol dehydrogenase
AL538_RS05075	COG1012	belongs to the aldehyde dehydrogenase family
AL538_RS05080	COG2095	MarC family integral membrane protein
AL538_RS05085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL538_RS05090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL538_RS05095	COG1757	Na H antiporter
AL538_RS05120	COG3083	sulfuric ester hydrolase activity
AL538_RS05130	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL538_RS05145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL538_RS05150	COG0778	Nitroreductase
AL538_RS05155	COG1902	pentaerythritol trinitrate reductase activity
AL538_RS05155	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL538_RS05160	COG0616	signal peptide processing
AL538_RS05165	COG0252	asparaginase activity
AL538_RS05170	COG3139	Protein of unknown function (DUF1315)
AL538_RS05180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL538_RS05185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL538_RS05205	COG2226	methyltransferase
AL538_RS05225	COG1785	Belongs to the alkaline phosphatase family
AL538_RS05235	COG0346	lactoylglutathione lyase activity
AL538_RS05240	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL538_RS05245	COG0668	transmembrane transport
AL538_RS05250	COG2261	transglycosylase associated protein
AL538_RS05260	COG2983	Belongs to the UPF0260 family
AL538_RS05270	COG2964	Protein conserved in bacteria
AL538_RS05280	COG0251	oxidation-reduction process
AL538_RS05285	COG0814	amino acid
AL538_RS05290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL538_RS05295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL538_RS05305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL538_RS05315	COG2832	Protein of unknown function (DUF454)
AL538_RS05325	COG0745	RESPONSE REGULATOR receiver
AL538_RS05330	COG0583	DNA-binding transcription factor activity
AL538_RS05335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL538_RS05340	COG1286	toxin biosynthetic process
AL538_RS05345	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL538_RS05350	COG0285	dihydrofolate synthase activity
AL538_RS05375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL538_RS05380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL538_RS05390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL538_RS05410	COG3101	peptidyl-lysine hydroxylation
AL538_RS05415	COG2860	membrane
AL538_RS05425	COG2890	protein-(glutamine-N5) methyltransferase activity
AL538_RS05435	COG2062	phosphohistidine phosphatase, SixA
AL538_RS05450	COG0183	Belongs to the thiolase family
AL538_RS05465	COG2067	long-chain fatty acid transport protein
AL538_RS05475	COG2853	Lipoprotein
AL538_RS05480	COG4235	cytochrome complex assembly
AL538_RS05480	COG3088	subunit of a heme lyase
AL538_RS05490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL538_RS05495	COG1138	Cytochrome C-type biogenesis protein
AL538_RS05510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL538_RS05515	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL538_RS05520	COG4133	protoheme IX ABC transporter activity
AL538_RS05530	COG0835	chemotaxis
AL538_RS05540	COG1192	Involved in chromosome partitioning
AL538_RS05545	COG2201	protein-glutamate methylesterase activity
AL538_RS05550	COG0643	Histidine kinase
AL538_RS05550	COG2198	Histidine kinase
AL538_RS05550	COG0784	Response regulator, receiver
AL538_RS05555	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL538_RS05590	COG1684	flagellar biosynthetic protein fliR
AL538_RS05595	COG1987	bacterial-type flagellum assembly
AL538_RS05650	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL538_RS05660	COG1677	Flagellar hook-basal body complex protein FliE
AL538_RS05680	COG1516	flagellar protein fliS
AL538_RS05690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL538_RS05695	COG1334	flagellar protein FlaG
AL538_RS05700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS05710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS05720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS05725	COG2211	Major facilitator Superfamily
AL538_RS05730	COG1486	melibiose metabolic process
AL538_RS05735	COG2169	Transcriptional regulator
AL538_RS05740	COG2837	iron assimilation
AL538_RS05765	COG1393	Belongs to the ArsC family
AL538_RS05785	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL538_RS05790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL538_RS05795	COG2716	regulation of RNA biosynthetic process
AL538_RS05800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL538_RS05815	COG4783	chaperone-mediated protein folding
AL538_RS05820	COG1393	Belongs to the ArsC family
AL538_RS05840	COG2233	PERMEase
AL538_RS05845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL538_RS05850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL538_RS05860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL538_RS05865	COG0121	glutamine amidotransferase
AL538_RS05870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL538_RS05895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL538_RS05905	COG2226	methyltransferase
AL538_RS05915	COG1388	LysM domain
AL538_RS05915	COG0741	lytic transglycosylase activity
AL538_RS05930	COG0347	Belongs to the P(II) protein family
AL538_RS05950	COG0587	DNA-directed DNA polymerase activity
AL538_RS05975	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL538_RS05980	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL538_RS05990	COG0750	zinc metalloprotease
AL538_RS06000	COG0575	Belongs to the CDS family
AL538_RS06005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL538_RS06030	COG0024	Methionine aminopeptidase
AL538_RS06045	COG0564	pseudouridine synthase activity
AL538_RS06050	COG3098	single-species biofilm formation
AL538_RS06090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL538_RS06115	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL538_RS06130	COG1720	tRNA m6t6A37 methyltransferase activity
AL538_RS06155	COG0733	neurotransmitter:sodium symporter activity
AL538_RS06170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL538_RS06175	COG0514	ATP-dependent DNA helicase (RecQ)
AL538_RS06180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL538_RS06195	COG1477	protein flavinylation
AL538_RS06205	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL538_RS06230	COG0271	Belongs to the BolA IbaG family
AL538_RS06260	COG1595	DNA-templated transcription, initiation
AL538_RS06280	COG3248	Nucleoside-binding outer membrane protein
AL538_RS06285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL538_RS06290	COG0693	protein deglycase activity
AL538_RS06295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL538_RS06300	COG2166	iron-sulfur cluster assembly
AL538_RS06305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL538_RS06310	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL538_RS06325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL538_RS06325	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL538_RS06335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL538_RS06340	COG1074	ATP-dependent DNA helicase activity
AL538_RS06345	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL538_RS06365	COG3141	response to X-ray
AL538_RS06380	COG2171	N-acyltransferase activity
AL538_RS06385	COG0584	glycerophosphoryl diester phosphodiesterase
AL538_RS06390	COG2271	Major facilitator Superfamily
AL538_RS06400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL538_RS06410	COG1349	DNA-binding transcription factor activity
AL538_RS06415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL538_RS06440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL538_RS06450	COG2017	converts alpha-aldose to the beta-anomer
AL538_RS06465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL538_RS06470	COG0768	penicillin binding
AL538_RS06480	COG1609	Transcriptional regulator
AL538_RS06485	COG3250	beta-galactosidase activity
AL538_RS06490	COG2731	YhcH YjgK YiaL family protein
AL538_RS06495	COG0531	amino acid
AL538_RS06500	COG0583	DNA-binding transcription factor activity
AL538_RS06560	COG4964	Belongs to the GSP D family
AL538_RS06585	COG2169	Transcriptional regulator
AL538_RS06590	COG1022	Amp-dependent synthetase and ligase
AL538_RS06600	COG0583	DNA-binding transcription factor activity
AL538_RS06605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL538_RS06610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL538_RS06620	COG0560	Phosphoserine phosphatase
AL538_RS06630	COG0813	purine-nucleoside phosphorylase activity
AL538_RS06640	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL538_RS06650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL538_RS06655	COG0084	hydrolase, TatD family'
AL538_RS06660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL538_RS06665	COG3706	GGDEF domain
AL538_RS06685	COG3153	acetyltransferase
AL538_RS06690	COG3154	lipid carrier protein
AL538_RS06700	COG0826	peptidase U32
AL538_RS06705	COG0826	peptidase U32
AL538_RS06710	COG0534	Mate efflux family protein
AL538_RS06730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL538_RS06750	COG0195	Participates in both transcription termination and antitermination
AL538_RS06770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL538_RS06780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL538_RS06785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL538_RS06795	COG1534	Rna-binding protein
AL538_RS06800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL538_RS06805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL538_RS06810	COG2027	D-alanyl-D-alanine carboxypeptidase
AL538_RS06820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL538_RS06825	COG0739	heme binding
AL538_RS06840	COG0316	Belongs to the HesB IscA family
AL538_RS06850	COG0628	permease
AL538_RS06865	COG2205	protein histidine kinase activity
AL538_RS06865	COG2198	Histidine kinase
AL538_RS06865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS06865	COG0784	Response regulator, receiver
AL538_RS06870	COG0747	negative chemotaxis
AL538_RS06880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL538_RS06885	COG0444	Belongs to the ABC transporter superfamily
AL538_RS06890	COG4608	Belongs to the ABC transporter superfamily
AL538_RS06900	COG2971	BadF BadG BcrA BcrD
AL538_RS06915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL538_RS06920	COG3842	ATPase activity
AL538_RS06930	COG1840	ABC-type Fe3 transport system, periplasmic component
AL538_RS06935	COG0004	ammonium transporteR
AL538_RS06950	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL538_RS06955	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL538_RS06960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL538_RS06965	COG1643	Atp-dependent helicase
AL538_RS06980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL538_RS06995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL538_RS07010	COG1560	Kdo2-lipid A biosynthetic process
AL538_RS07015	COG0842	Transport permease protein
AL538_RS07020	COG1131	(ABC) transporter
AL538_RS07025	COG0659	secondary active sulfate transmembrane transporter activity
AL538_RS07030	COG0288	reversible hydration of carbon dioxide
AL538_RS07045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL538_RS07050	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL538_RS07055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL538_RS07060	COG2186	Transcriptional regulator
AL538_RS07085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL538_RS07090	COG1459	type II secretion system
AL538_RS07100	COG0237	dephospho-CoA kinase activity
AL538_RS07105	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL538_RS07110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL538_RS07135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL538_RS07140	COG4137	Cytochrome C assembly protein
AL538_RS07145	COG4536	flavin adenine dinucleotide binding
AL538_RS07165	COG0612	Peptidase, M16
AL538_RS07170	COG1238	metal cluster binding
AL538_RS07180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL538_RS07185	COG0511	ligase activity, forming carbon-carbon bonds
AL538_RS07185	COG5016	pyruvate
AL538_RS07190	COG3630	sodium ion export across plasma membrane
AL538_RS07250	COG0527	aspartate kinase activity
AL538_RS07265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL538_RS07270	COG1546	Belongs to the CinA family
AL538_RS07280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL538_RS07310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL538_RS07320	COG0148	phosphopyruvate hydratase activity
AL538_RS07330	COG3956	TIGRFAM MazG family protein
AL538_RS07335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL538_RS07360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL538_RS07365	COG1381	Involved in DNA repair and RecF pathway recombination
AL538_RS07370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL538_RS07390	COG3086	response to oxidative stress
AL538_RS07405	COG1595	DNA-templated transcription, initiation
AL538_RS07415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL538_RS07425	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL538_RS07445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL538_RS07450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL538_RS07465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL538_RS07475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL538_RS07485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL538_RS07495	COG0583	DNA-binding transcription factor activity
AL538_RS07510	COG0668	transmembrane transport
AL538_RS07515	COG0191	fructose-bisphosphate aldolase activity
AL538_RS07535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL538_RS07560	COG2356	endonuclease I
AL538_RS07565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL538_RS07570	COG0189	ligase activity
AL538_RS07575	COG1678	Uncharacterized ACR, COG1678
AL538_RS07580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL538_RS07595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL538_RS07600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL538_RS07605	COG0762	integral membrane protein
AL538_RS07620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL538_RS07625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL538_RS07725	COG1012	belongs to the aldehyde dehydrogenase family
AL538_RS07775	COG3437	response regulator, receiver
AL538_RS07790	COG1486	melibiose metabolic process
AL538_RS07795	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL538_RS07805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL538_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS07835	COG0795	lipopolysaccharide-transporting ATPase activity
AL538_RS07840	COG0795	lipopolysaccharide-transporting ATPase activity
AL538_RS07850	COG2927	DNA polymerase III (CHI subunit)
AL538_RS07855	COG0525	valine-tRNA ligase activity
AL538_RS07865	COG0456	acetyltransferase
AL538_RS07905	COG0251	oxidation-reduction process
AL538_RS07910	COG0204	Acyl-transferase
AL538_RS07920	COG5007	Belongs to the BolA IbaG family
AL538_RS07930	COG2854	intermembrane phospholipid transfer
AL538_RS07935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL538_RS07940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL538_RS07945	COG1127	ABC transporter
AL538_RS07955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL538_RS07955	COG0517	IMP dehydrogenase activity
AL538_RS07965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL538_RS07970	COG1137	ATPase activity
AL538_RS07980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL538_RS07985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS07995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS08000	COG2239	Acts as a magnesium transporter
AL538_RS08005	COG0312	modulator of DNA gyrase
AL538_RS08015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL538_RS08020	COG0564	pseudouridine synthase activity
AL538_RS08035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL538_RS08040	COG0312	modulator of DNA gyrase
AL538_RS08045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL538_RS08050	COG3164	Protein of unknown function
AL538_RS08060	COG0424	maF-like protein
AL538_RS08065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL538_RS08070	COG1792	Involved in formation and maintenance of cell shape
AL538_RS08075	COG1077	Cell shape determining protein MreB Mrl
AL538_RS08110	COG2165	general secretion pathway protein
AL538_RS08120	COG1459	type II secretion system
AL538_RS08125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL538_RS08135	COG3409	Peptidoglycan-binding domain 1 protein
AL538_RS08135	COG3267	Type II secretory pathway component ExeA
AL538_RS08160	COG2199	diguanylate cyclase activity
AL538_RS08160	COG2200	EAL domain
AL538_RS08165	COG0629	single-stranded DNA binding
AL538_RS08180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL538_RS08190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL538_RS08200	COG0527	aspartate kinase activity
AL538_RS08205	COG1410	methionine synthase
AL538_RS08205	COG0646	methionine synthase
AL538_RS08280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL538_RS08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL538_RS08305	COG0735	belongs to the Fur family
AL538_RS08320	COG0432	Pfam Uncharacterised protein family UPF0047
AL538_RS08330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL538_RS08335	COG0305	Participates in initiation and elongation during chromosome replication
AL538_RS08355	COG0360	Binds together with S18 to 16S ribosomal RNA
AL538_RS08360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL538_RS08365	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL538_RS08410	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL538_RS08420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL538_RS08420	COG0678	peroxiredoxin activity
AL538_RS08425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL538_RS08440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL538_RS08440	COG0165	Argininosuccinate lyase
AL538_RS08455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL538_RS08465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL538_RS08475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL538_RS08480	COG0460	homoserine dehydrogenase
AL538_RS08480	COG0527	aspartate kinase activity
AL538_RS08485	COG0626	cystathionine gamma-synthase activity
AL538_RS08495	COG0281	malic enzyme
AL538_RS08505	COG2906	2 iron, 2 sulfur cluster binding
AL538_RS08515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL538_RS08530	COG2168	tRNA wobble position uridine thiolation
AL538_RS08535	COG2923	Belongs to the DsrF TusC family
AL538_RS08540	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL538_RS08545	COG2964	Protein conserved in bacteria
AL538_RS08550	COG0545	Peptidyl-prolyl cis-trans isomerase
AL538_RS08565	COG1446	asparaginase
AL538_RS08575	COG1047	Peptidyl-prolyl cis-trans
AL538_RS08590	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL538_RS08600	COG0488	(ABC) transporter
AL538_RS08610	COG0429	hydrolase of the alpha beta-hydrolase fold
AL538_RS08620	COG3954	Phosphoribulokinase
AL538_RS08625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL538_RS08645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL538_RS08650	COG0512	Glutamine amidotransferase of anthranilate synthase
AL538_RS08675	COG0546	phosphoglycolate phosphatase activity
AL538_RS08680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL538_RS08685	COG0557	exoribonuclease II activity
AL538_RS08695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL538_RS08695	COG1017	nitric oxide dioxygenase activity
AL538_RS08700	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL538_RS08710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL538_RS08715	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL538_RS08720	COG0330	HflC and HflK could
AL538_RS08725	COG0330	HflC and HflK could
AL538_RS08730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL538_RS08745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL538_RS08755	COG0802	atpase or kinase
AL538_RS08760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL538_RS08830	COG1162	GTPase activity
AL538_RS08840	COG0471	metal ion transport
AL538_RS08845	COG0840	transmembrane signaling receptor activity
AL538_RS08855	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL538_RS08860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL538_RS08865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL538_RS08875	COG1045	serine acetyltransferase
AL538_RS08880	COG4942	peptidase
AL538_RS08905	COG1053	succinate dehydrogenase
AL538_RS08910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL538_RS08940	COG1509	lysine 2,3-aminomutase activity
AL538_RS08990	COG0534	Mate efflux family protein
AL538_RS09000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL538_RS09005	COG3678	ATP-independent chaperone mediated protein folding
AL538_RS09010	COG0745	RESPONSE REGULATOR receiver
AL538_RS09015	COG2205	protein histidine kinase activity
AL538_RS09020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL538_RS09025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL538_RS09030	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL538_RS09035	COG1027	Aspartate ammonia-lyase
AL538_RS09040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL538_RS09045	COG4232	protein-disulfide reductase activity
AL538_RS09055	COG2095	MarC family integral membrane protein
AL538_RS09065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS09085	COG0784	Response regulator, receiver
AL538_RS09085	COG2198	Histidine kinase
AL538_RS09085	COG2205	protein histidine kinase activity
AL538_RS09090	COG2814	Major facilitator Superfamily
AL538_RS09105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL538_RS09110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL538_RS09115	COG0511	ligase activity, forming carbon-carbon bonds
AL538_RS09120	COG0439	Biotin carboxylase
AL538_RS09135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL538_RS09140	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL538_RS09145	COG2199	diguanylate cyclase activity
AL538_RS09200	COG1982	Orn Lys Arg decarboxylase major
AL538_RS09205	COG0531	amino acid
AL538_RS09215	COG3710	Transcriptional regulator
AL538_RS09220	COG0789	Transcriptional regulator
AL538_RS09235	COG0151	Belongs to the GarS family
AL538_RS09250	COG1253	flavin adenine dinucleotide binding
AL538_RS09255	COG3068	Protein conserved in bacteria
AL538_RS09265	COG1573	uracil-dna glycosylase
AL538_RS09285	COG2816	NAD+ diphosphatase activity
AL538_RS09290	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL538_RS09315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL538_RS09330	COG0250	Participates in transcription elongation, termination and antitermination
AL538_RS09335	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL538_RS09380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL538_RS09390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL538_RS09540	COG3339	Conserved Protein
AL538_RS09555	COG2003	Belongs to the UPF0758 family
AL538_RS09575	COG0582	viral genome integration into host DNA
AL538_RS09590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL538_RS09595	COG0534	Mate efflux family protein
AL538_RS09615	COG2937	Belongs to the GPAT DAPAT family
AL538_RS09625	COG3161	chorismate lyase activity
AL538_RS09630	COG1580	Controls the rotational direction of flagella during chemotaxis
AL538_RS09635	COG0705	Rhomboid family
AL538_RS09650	COG2177	Part of the ABC transporter FtsEX involved in
AL538_RS09655	COG2884	Cell division ATP-binding protein ftsE
AL538_RS09660	COG0552	protein localization to endoplasmic reticulum
AL538_RS09665	COG0742	ribosomal rna small subunit methyltransferase
AL538_RS09675	COG2095	MarC family integral membrane protein
AL538_RS09725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL538_RS09730	COG0640	Transcriptional regulator
AL538_RS09735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL538_RS09740	COG1280	lysine exporter protein (LysE YggA)
AL538_RS09745	COG2267	carboxylic ester hydrolase activity
AL538_RS09750	COG0561	phosphatase activity
AL538_RS09765	COG3148	PFAM DTW domain containing protein
AL538_RS09770	COG3287	FIST C domain
AL538_RS09770	COG2199	diguanylate cyclase activity
AL538_RS09770	COG2200	EAL domain
AL538_RS09775	COG1011	Hydrolase
AL538_RS09795	COG0019	diaminopimelate decarboxylase activity
AL538_RS09810	COG3072	Adenylate cyclase
AL538_RS09820	COG1587	Uroporphyrinogen-III synthase
AL538_RS09825	COG2959	enzyme of heme biosynthesis
AL538_RS09830	COG3071	HemY protein
AL538_RS09875	COG0633	Ferredoxin
AL538_RS09880	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL538_RS09895	COG3118	belongs to the thioredoxin family
AL538_RS09910	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL538_RS09925	COG0514	ATP-dependent DNA helicase (RecQ)
AL538_RS09930	COG2962	Rard protein
AL538_RS09940	COG1280	lysine exporter protein (LysE YggA)
AL538_RS09945	COG0405	Gamma-glutamyltransferase
AL538_RS09960	COG0210	DNA helicase
AL538_RS09970	COG3220	belongs to the UPF0276 family
AL538_RS09990	COG2814	Major facilitator Superfamily
AL538_RS10000	COG0006	proline dipeptidase activity
AL538_RS10000	COG0006	proline dipeptidase activity
AL538_RS10015	COG2104	thiamine diphosphate biosynthetic process
AL538_RS10020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL538_RS10040	COG2132	Multicopper oxidase
AL538_RS10085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL538_RS10095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL538_RS10110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL538_RS10115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL538_RS10120	COG0551	DNA topoisomerase type I activity
AL538_RS10130	COG0758	DNA mediated transformation
AL538_RS10140	COG0242	peptide deformylase activity
AL538_RS10150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL538_RS10150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL538_RS10155	COG0569	domain protein
AL538_RS10160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL538_RS10170	COG1272	protein, Hemolysin III
AL538_RS10175	COG4326	sporulation control protein
AL538_RS10185	COG3084	Protein conserved in bacteria
AL538_RS10195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL538_RS10200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL538_RS10205	COG0204	Acyl-transferase
AL538_RS10215	COG3706	GGDEF domain
AL538_RS10220	COG0606	chelatase, subunit chli
AL538_RS10230	COG3978	acetolactate synthase activity
AL538_RS10235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL538_RS10240	COG0129	dihydroxy-acid dehydratase activity
AL538_RS10250	COG0583	DNA-binding transcription factor activity
AL538_RS10255	COG2814	Major facilitator Superfamily
AL538_RS10265	COG0765	amino acid transport
AL538_RS10275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL538_RS10285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL538_RS10310	COG0356	it plays a direct role in the translocation of protons across the membrane
AL538_RS10315	COG3312	ion transport
AL538_RS10320	COG1475	DNA binding
AL538_RS10325	COG1192	Involved in chromosome partitioning
AL538_RS10335	COG0445	tRNA wobble uridine modification
AL538_RS10340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL538_RS10370	COG1126	abc transporter atp-binding protein
AL538_RS10395	COG0592	DNA-directed DNA polymerase activity
AL538_RS10405	COG0187	DNA topoisomerase II activity
AL538_RS10410	COG0071	Belongs to the small heat shock protein (HSP20) family
AL538_RS10415	COG3977	Valine--pyruvate aminotransferase
AL538_RS10420	COG0366	Alpha amylase catalytic
AL538_RS10435	COG2119	membrane
AL538_RS10445	COG0425	Belongs to the sulfur carrier protein TusA family
AL538_RS10460	COG0604	alcohol dehydrogenase
AL538_RS10465	COG0183	Belongs to the thiolase family
AL538_RS10475	COG1739	Uncharacterized protein family UPF0029
AL538_RS10480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL538_RS10535	COG0583	DNA-binding transcription factor activity
AL538_RS10540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL538_RS10545	COG2960	long-chain fatty acid transporting porin activity
AL538_RS10555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS10560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS10565	COG1309	transcriptional regulator
AL538_RS10605	COG0546	phosphoglycolate phosphatase activity
AL538_RS10615	COG4172	Belongs to the ABC transporter superfamily
AL538_RS10620	COG0747	negative chemotaxis
AL538_RS10625	COG0601	transmembrane transport
AL538_RS10630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL538_RS10665	COG1609	Transcriptional regulator
AL538_RS10670	COG0583	DNA-binding transcription factor activity
AL538_RS10675	COG2076	Multidrug Resistance protein
AL538_RS10690	COG0129	dihydroxy-acid dehydratase activity
AL538_RS10695	COG3265	gluconokinase activity
AL538_RS10700	COG2610	gluconate transmembrane transporter activity
AL538_RS10705	COG0800	Aldolase
AL538_RS10710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL538_RS10725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL538_RS10740	COG1522	sequence-specific DNA binding
AL538_RS10745	COG5002	protein histidine kinase activity
AL538_RS10745	COG5001	Diguanylate cyclase
AL538_RS10770	COG0589	response to stress
AL538_RS10780	COG1528	Iron-storage protein
AL538_RS10790	COG2081	HI0933 family
AL538_RS10805	COG1322	Protein conserved in bacteria
AL538_RS10815	COG3165	ubiquinone biosynthetic process from chorismate
AL538_RS10830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL538_RS10835	COG0805	protein transport
AL538_RS10840	COG0084	hydrolase, TatD family'
AL538_RS10860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL538_RS10860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL538_RS10870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL538_RS10900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL538_RS10910	COG2204	response regulator
AL538_RS10915	COG3852	Histidine kinase
AL538_RS10925	COG0174	glutamine synthetase
AL538_RS10935	COG1217	gtp-binding protein TYPA
AL538_RS10955	COG1490	D-aminoacyl-tRNA deacylase activity
AL538_RS10960	COG0456	acetyltransferase
AL538_RS10980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL538_RS10985	COG3031	protein transport across the cell outer membrane
AL538_RS10995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL538_RS11000	COG1459	type II secretion system
AL538_RS11005	COG2165	general secretion pathway protein
AL538_RS11010	COG2165	general secretion pathway protein
AL538_RS11015	COG2165	general secretion pathway protein
AL538_RS11020	COG4795	General secretion pathway protein
AL538_RS11025	COG3156	type II secretion system protein K
AL538_RS11030	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL538_RS11035	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL538_RS11045	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL538_RS11050	COG0494	nUDIX hydrolase
AL538_RS11060	COG1040	competence protein
AL538_RS11075	COG2183	response to ionizing radiation
AL538_RS11085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL538_RS11100	COG2233	PERMEase
AL538_RS11110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL538_RS11115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL538_RS11120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL538_RS11125	COG1758	RNA polymerase activity
AL538_RS11130	COG0194	GDP metabolic process
AL538_RS11145	COG0848	biopolymer transport protein
AL538_RS11150	COG0811	peptide transport
AL538_RS11175	COG4174	ABC transporter (Permease)
AL538_RS11180	COG4239	(ABC) transporter, permease
AL538_RS11185	COG0747	negative chemotaxis
AL538_RS11190	COG0444	Belongs to the ABC transporter superfamily
AL538_RS11195	COG4608	Belongs to the ABC transporter superfamily
AL538_RS11220	COG0745	RESPONSE REGULATOR receiver
AL538_RS11225	COG1561	YicC-like family, N-terminal region
AL538_RS11230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL538_RS11235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL538_RS11240	COG1560	Kdo2-lipid A biosynthetic process
AL538_RS11250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL538_RS11260	COG0840	transmembrane signaling receptor activity
AL538_RS11280	COG2194	sulfuric ester hydrolase activity
AL538_RS11295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL538_RS11310	COG0463	Glycosyl transferase, family 2
AL538_RS11315	COG0859	PFAM glycosyl transferase family 9
AL538_RS11320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL538_RS11325	COG3642	lipopolysaccharide core region biosynthetic process
AL538_RS11335	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AL538_RS11365	COG1519	Transferase
AL538_RS11370	COG0859	PFAM glycosyl transferase family 9
AL538_RS11380	COG1560	Kdo2-lipid A biosynthetic process
AL538_RS11390	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL538_RS11430	COG4750	Nucleotidyl transferase
AL538_RS11440	COG3475	LICD family
AL538_RS11450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL538_RS11475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL538_RS11485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL538_RS11490	COG0149	triose-phosphate isomerase activity
AL538_RS11520	COG1494	fructose-1,6-bisphosphatase
AL538_RS11530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL538_RS11535	COG1575	Belongs to the MenA family. Type 1 subfamily
AL538_RS11555	COG1609	Transcriptional regulator
AL538_RS11560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL538_RS11570	COG0254	rRNA binding
AL538_RS11585	COG0088	Forms part of the polypeptide exit tunnel
AL538_RS11605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL538_RS11655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL538_RS11670	COG1841	ribosomal large subunit assembly
AL538_RS11675	COG0200	Binds to the 23S rRNA
AL538_RS11680	COG0201	protein transport
AL538_RS11685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL538_RS11690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL538_RS11695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL538_RS11705	COG0202	RNA polymerase activity
AL538_RS11710	COG0203	ribosomal protein L17
AL538_RS11720	COG0545	Peptidyl-prolyl cis-trans isomerase
AL538_RS11735	COG2153	protein acetylation
AL538_RS11740	COG0513	Belongs to the DEAD box helicase family
AL538_RS11750	COG0737	Belongs to the 5'-nucleotidase family
AL538_RS11755	COG1648	precorrin-2 dehydrogenase activity
AL538_RS11755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL538_RS11770	COG3273	potassium ion transport
AL538_RS11770	COG0471	metal ion transport
AL538_RS11775	COG0529	Catalyzes the synthesis of activated sulfate
AL538_RS11795	COG1136	(ABC) transporter
AL538_RS11810	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL538_RS11820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL538_RS11825	COG0729	surface antigen
AL538_RS11835	COG2105	PFAM AIG2 family protein
AL538_RS11845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL538_RS11855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL538_RS11860	COG0163	prenyltransferase activity
AL538_RS11865	COG4143	(ABC) transporter
AL538_RS11870	COG1178	ABC-type Fe3 transport system permease component
AL538_RS11875	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL538_RS11915	COG0142	geranyltranstransferase activity
AL538_RS11920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL538_RS11930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL538_RS11935	COG2966	Psort location CytoplasmicMembrane, score
AL538_RS11940	COG3610	response to peptide
AL538_RS11960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL538_RS11965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL538_RS11970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL538_RS11975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL538_RS11980	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL538_RS12000	COG0473	3-isopropylmalate dehydrogenase activity
AL538_RS12005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL538_RS12020	COG0671	phosphoesterase, PA-phosphatase related
AL538_RS12030	COG0583	DNA-binding transcription factor activity
AL538_RS12035	COG1022	Amp-dependent synthetase and ligase
AL538_RS12040	COG0028	Belongs to the TPP enzyme family
AL538_RS12045	COG0440	acetolactate synthase activity
AL538_RS12050	COG3706	GGDEF domain
AL538_RS12060	COG0469	pyruvate kinase activity
AL538_RS12070	COG1349	DNA-binding transcription factor activity
AL538_RS12075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL538_RS12095	COG5002	protein histidine kinase activity
AL538_RS12100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL538_RS12105	COG3722	fumarate hydratase activity
AL538_RS12115	COG2213	PTS system mannitol-specific
AL538_RS12115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS12150	COG0358	DNA primase activity
AL538_RS12155	COG1610	YqeY-like protein
AL538_RS12160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL538_RS12165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL538_RS12170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL538_RS12180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL538_RS12185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL538_RS12200	COG3267	Type II secretory pathway component ExeA
AL538_RS12200	COG3409	Peptidoglycan-binding domain 1 protein
AL538_RS12210	COG4991	sh3 domain protein
AL538_RS12215	COG0306	phosphate transporter
AL538_RS12220	COG1392	Phosphate transport regulator
AL538_RS12225	COG3025	triphosphatase activity
AL538_RS12230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL538_RS12240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL538_RS12250	COG1538	Outer membrane efflux protein
AL538_RS12255	COG0494	nUDIX hydrolase
AL538_RS12260	COG3151	Protein conserved in bacteria
AL538_RS12270	COG3150	esterase
AL538_RS12280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL538_RS12285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL538_RS12300	COG3105	Protein conserved in bacteria
AL538_RS12310	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL538_RS12330	COG0723	plastoquinol--plastocyanin reductase activity
AL538_RS12335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL538_RS12340	COG2857	Cytochrome c1
AL538_RS12345	COG0625	glutathione transferase activity
AL538_RS12350	COG2969	positive regulation of protein catabolic process
AL538_RS12355	COG2823	Periplasmic or secreted lipoprotein
AL538_RS12360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL538_RS12375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL538_RS12395	COG3116	cell division
AL538_RS12400	COG0768	penicillin binding
AL538_RS12405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL538_RS12410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL538_RS12425	COG0772	Belongs to the SEDS family
AL538_RS12440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL538_RS12445	COG0849	cell division
AL538_RS12450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL538_RS12465	COG0494	nUDIX hydrolase
AL538_RS12475	COG0505	Belongs to the CarA family
AL538_RS12480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL538_RS12500	COG0730	response to heat
AL538_RS12505	COG0583	DNA-binding transcription factor activity
AL538_RS12510	COG2860	membrane
AL538_RS12535	COG0493	'glutamate synthase
AL538_RS12540	COG0067	glutamate synthase
AL538_RS12540	COG0070	glutamate synthase
AL538_RS12540	COG0069	glutamate synthase activity
AL538_RS12550	COG0070	glutamate synthase
AL538_RS12550	COG0069	glutamate synthase activity
AL538_RS12550	COG0067	glutamate synthase
AL538_RS12555	COG1242	4 iron, 4 sulfur cluster binding
AL538_RS12560	COG2203	Gaf domain
AL538_RS12560	COG5001	Diguanylate cyclase
AL538_RS12560	COG4251	negative regulation of phosphorylation
AL538_RS12560	COG3706	GGDEF domain
AL538_RS12570	COG0784	Response regulator, receiver
AL538_RS12570	COG2198	Histidine kinase
AL538_RS12570	COG5002	protein histidine kinase activity
AL538_RS12580	COG0745	RESPONSE REGULATOR receiver
AL538_RS12595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL538_RS12610	COG0083	homoserine kinase activity
AL538_RS12615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL538_RS12620	COG0431	NADPH-dependent FMN reductase
AL538_RS12655	COG1115	amino acid carrier protein
AL538_RS12660	COG3022	response to hydroperoxide
AL538_RS12670	COG0513	Belongs to the DEAD box helicase family
AL538_RS12685	COG0716	FMN binding
AL538_RS12690	COG4974	Belongs to the 'phage' integrase family
AL538_RS12695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL538_RS12700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL538_RS12725	COG0667	Aldo Keto reductase
AL538_RS12745	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AL538_RS12750	COG0730	response to heat
AL538_RS12765	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL538_RS12770	COG0583	DNA-binding transcription factor activity
AL538_RS12775	COG0640	Transcriptional regulator
AL538_RS12780	COG0268	Binds directly to 16S ribosomal RNA
AL538_RS12785	COG0728	peptidoglycan biosynthetic process
AL538_RS12790	COG0196	riboflavin kinase activity
AL538_RS12805	COG1047	Peptidyl-prolyl cis-trans
AL538_RS12810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL538_RS12815	COG3279	Response regulator of the LytR AlgR family
AL538_RS12820	COG3275	phosphorelay sensor kinase activity
AL538_RS12825	COG1966	Carbon starvation protein
AL538_RS12845	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL538_RS12855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL538_RS12860	COG1605	Chorismate mutase
AL538_RS12860	COG0287	Prephenate dehydrogenase
AL538_RS12865	COG0739	heme binding
AL538_RS12875	COG0488	(ABC) transporter
AL538_RS12890	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL538_RS12895	COG0077	Prephenate dehydratase
AL538_RS12895	COG1605	Chorismate mutase
AL538_RS12900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL538_RS12905	COG0741	lytic transglycosylase activity
AL538_RS12910	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL538_RS12915	COG0564	pseudouridine synthase activity
AL538_RS12920	COG1496	oxidoreductase activity
AL538_RS12925	COG0542	response to heat
AL538_RS12990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL538_RS12995	COG0826	peptidase U32
AL538_RS13005	COG0745	RESPONSE REGULATOR receiver
AL538_RS13010	COG5002	protein histidine kinase activity
AL538_RS13020	COG0248	Ppx GppA phosphatase
AL538_RS13025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL538_RS13030	COG0573	inorganic phosphate transmembrane transporter activity
AL538_RS13035	COG0581	inorganic phosphate transmembrane transporter activity
AL538_RS13040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL538_RS13045	COG0704	Plays a role in the regulation of phosphate uptake
AL538_RS13075	COG0450	alkyl hydroperoxide reductase
AL538_RS13080	COG0583	DNA-binding transcription factor activity
AL538_RS13090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL538_RS13100	COG0517	IMP dehydrogenase activity
AL538_RS13125	COG1862	Preprotein translocase
AL538_RS13130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL538_RS13135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL538_RS13150	COG0483	inositol monophosphate 1-phosphatase activity
AL538_RS13155	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL538_RS13170	COG0822	iron-sulfur transferase activity
AL538_RS13175	COG0316	Belongs to the HesB IscA family
AL538_RS13190	COG0633	Ferredoxin
AL538_RS13195	COG2975	iron-sulfur cluster assembly
AL538_RS13230	COG2976	Protein conserved in bacteria
AL538_RS13235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL538_RS13250	COG2203	Gaf domain
AL538_RS13250	COG2199	diguanylate cyclase activity
AL538_RS13265	COG0516	GMP reductase activity
AL538_RS13265	COG0517	IMP dehydrogenase activity
AL538_RS13275	COG1757	Na H antiporter
AL538_RS13285	COG1584	GPR1 FUN34 yaaH family protein
AL538_RS13290	COG1115	amino acid carrier protein
AL538_RS13300	COG0583	DNA-binding transcription factor activity
AL538_RS13315	COG2873	o-acetylhomoserine
AL538_RS13320	COG0316	Belongs to the HesB IscA family
AL538_RS13325	COG0719	Fe-S assembly protein
AL538_RS13330	COG0396	ATPase activity
AL538_RS13335	COG0719	Fe-S assembly protein
AL538_RS13355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL538_RS13375	COG1289	transmembrane transporter activity
AL538_RS13380	COG0583	DNA-binding transcription factor activity
AL538_RS13440	COG2003	Belongs to the UPF0758 family
AL538_RS13500	COG0582	viral genome integration into host DNA
AL538_RS13515	COG2867	negative regulation of translational initiation
AL538_RS13520	COG2914	Belongs to the UPF0125 (RnfH) family
AL538_RS13525	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL538_RS13530	COG0497	DNA recombination
AL538_RS13550	COG1301	dicarboxylic acid transport
AL538_RS13575	COG4969	Belongs to the N-Me-Phe pilin family
AL538_RS13595	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL538_RS13600	COG0590	tRNA wobble adenosine to inosine editing
AL538_RS13615	COG0047	phosphoribosylformylglycinamidine synthase activity
AL538_RS13615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL538_RS13645	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL538_RS13650	COG2252	PERMEase
AL538_RS13655	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL538_RS13660	COG1073	alpha beta
AL538_RS13675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL538_RS13680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL538_RS13685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL538_RS13685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL538_RS13710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL538_RS13715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL538_RS13725	COG0142	geranyltranstransferase activity
AL538_RS13735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL538_RS13750	COG0583	DNA-binding transcription factor activity
AL538_RS13760	COG2363	Small membrane protein
AL538_RS13780	COG1611	Belongs to the LOG family
AL538_RS13805	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL538_RS13810	COG0737	Belongs to the 5'-nucleotidase family
AL538_RS13820	COG1464	Belongs to the NlpA lipoprotein family
AL538_RS13825	COG2011	ABC-type metal ion transport system permease component
AL538_RS13830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL538_RS13835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL538_RS13845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS13845	COG1263	PTS System
AL538_RS13850	COG0366	Alpha amylase catalytic
AL538_RS13865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL538_RS13870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL538_RS13890	COG1686	Belongs to the peptidase S11 family
AL538_RS13895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL538_RS13900	COG0772	Belongs to the SEDS family
AL538_RS13905	COG0768	penicillin binding
AL538_RS13915	COG0799	negative regulation of ribosome biogenesis
AL538_RS13920	COG1466	dna polymerase III delta subunit
AL538_RS13925	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL538_RS13935	COG2888	peptidyl-tyrosine sulfation
AL538_RS13940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL538_RS13945	COG4535	Mg2 and Co2 transporter CorC
AL538_RS13955	COG1702	phosphate starvation-inducible protein PhoH
AL538_RS13970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL538_RS14095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL538_RS14120	COG2890	protein-(glutamine-N5) methyltransferase activity
AL538_RS14125	COG3094	Invasion gene expression up-regulator, SirB
AL538_RS14130	COG2912	Transglutaminase-like superfamily
AL538_RS14135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL538_RS14140	COG0737	Belongs to the 5'-nucleotidase family
AL538_RS14145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL538_RS14150	COG1187	pseudouridine synthase activity
AL538_RS14155	COG2840	Smr protein MutS2
AL538_RS14200	COG2608	mercury ion transmembrane transporter activity
AL538_RS14200	COG2217	Heavy metal translocating P-type atpase
AL538_RS14215	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL538_RS14280	COG0835	chemotaxis
AL538_RS14280	COG0784	Response regulator, receiver
AL538_RS14285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL538_RS14290	COG1815	bacterial-type flagellum-dependent cell motility
AL538_RS14295	COG1558	bacterial-type flagellum-dependent cell motility
AL538_RS14315	COG4787	bacterial-type flagellum-dependent cell motility
AL538_RS14325	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL538_RS14330	COG1706	bacterial-type flagellum-dependent cell motility
AL538_RS14335	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL538_RS14335	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL538_RS14350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS14355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS14360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS14365	COG2190	(PTS) system
AL538_RS14370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL538_RS14375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS14385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL538_RS14390	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL538_RS14425	COG0330	HflC and HflK could
AL538_RS14430	COG3118	belongs to the thioredoxin family
AL538_RS14440	COG0300	oxidoreductase activity
AL538_RS14445	COG1090	epimerase
AL538_RS14475	COG0622	Phosphoesterase
AL538_RS14495	COG3710	Transcriptional regulator
AL538_RS14510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL538_RS14515	COG3104	oligopeptide transport
AL538_RS14525	COG0367	asparagine synthase
AL538_RS14530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL538_RS14530	COG4651	solute:proton antiporter activity
AL538_RS14535	COG1940	carbohydrate kinase activity
AL538_RS14535	COG1846	Transcriptional regulator
AL538_RS14540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL538_RS14550	COG1263	PTS System
AL538_RS14550	COG2190	(PTS) system
AL538_RS14550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS14560	COG2165	general secretion pathway protein
AL538_RS14565	COG0735	belongs to the Fur family
AL538_RS14575	COG0716	FMN binding
AL538_RS14585	COG0596	Alpha beta hydrolase
AL538_RS14590	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL538_RS14595	COG0033	Phosphoglucomutase
AL538_RS14610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL538_RS14625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL538_RS14630	COG1053	succinate dehydrogenase
AL538_RS14640	COG0567	Dehydrogenase, E1 component
AL538_RS14645	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL538_RS14660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL538_RS14665	COG1121	(ABC) transporter
AL538_RS14670	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL538_RS14675	COG4977	sequence-specific DNA binding
AL538_RS14680	COG1918	ferrous iron import across plasma membrane
AL538_RS14715	COG3102	Protein conserved in bacteria
AL538_RS14720	COG0788	formyltetrahydrofolate deformylase activity
AL538_RS14725	COG1199	ATP-dependent helicase activity
AL538_RS14730	COG1214	PFAM Peptidase M22, glycoprotease
AL538_RS14740	COG3065	identical protein binding
AL538_RS14745	COG2267	carboxylic ester hydrolase activity
AL538_RS14750	COG0318	PFAM AMP-dependent synthetase and ligase
AL538_RS14755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL538_RS14760	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL538_RS14765	COG2894	cell division
AL538_RS14780	COG2951	lytic endotransglycosylase activity
AL538_RS14790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL538_RS14830	COG3675	Pfam Lipase (class 3)
AL538_RS14850	COG1715	Restriction endonuclease
AL538_RS14855	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL538_RS14920	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS14955	COG2986	histidine ammonia-lyase
AL538_RS14960	COG1216	Glycosyl transferase, family 2
AL538_RS14980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL538_RS14985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL538_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS15035	COG1169	isochorismate synthase
AL538_RS15040	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL538_RS15045	COG1535	isochorismatase
AL538_RS15045	COG3433	isochorismatase activity
AL538_RS15050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL538_RS15050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL538_RS15065	COG4771	TonB-dependent receptor
AL538_RS15070	COG1253	flavin adenine dinucleotide binding
AL538_RS15075	COG0513	Belongs to the DEAD box helicase family
AL538_RS15080	COG0569	domain protein
AL538_RS15085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL538_RS15100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL538_RS15105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL538_RS15110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL538_RS15125	COG4191	Histidine kinase
AL538_RS15145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL538_RS15150	COG0776	regulation of translation
AL538_RS15155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL538_RS15180	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL538_RS15185	COG0436	Aminotransferase
AL538_RS15190	COG1169	isochorismate synthase
AL538_RS15200	COG0596	Alpha beta hydrolase
AL538_RS15205	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL538_RS15220	COG2190	(PTS) system
AL538_RS15220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS15220	COG1263	PTS System
AL538_RS15225	COG0583	DNA-binding transcription factor activity
AL538_RS15245	COG2855	membrane
AL538_RS15250	COG0477	Major facilitator Superfamily
AL538_RS15300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS15325	COG1522	sequence-specific DNA binding
AL538_RS15335	COG3385	transposase activity
AL538_RS15340	COG1946	Acyl-CoA thioesterase
AL538_RS15345	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL538_RS15370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AL538_RS15375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL538_RS15380	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL538_RS15385	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AL538_RS15390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL538_RS15390	COG0517	IMP dehydrogenase activity
AL538_RS15390	COG0617	tRNA 3'-terminal CCA addition
AL538_RS15400	COG2217	Heavy metal translocating P-type atpase
AL538_RS15420	COG0537	adenosine 5'-monophosphoramidase activity
AL538_RS15450	COG1252	NADH dehydrogenase
AL538_RS15465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL538_RS15475	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL538_RS15480	COG1136	(ABC) transporter
AL538_RS15485	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL538_RS15500	COG1132	(ABC) transporter
AL538_RS15520	COG2719	SpoVR family
AL538_RS15525	COG2718	Belongs to the UPF0229 family
AL538_RS15530	COG2766	serine protein kinase
AL538_RS15550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL538_RS15560	COG1882	Formate acetyltransferase
AL538_RS15605	COG0708	Exodeoxyribonuclease III
AL538_RS15610	COG0840	transmembrane signaling receptor activity
AL538_RS15625	COG0730	response to heat
AL538_RS15630	COG1199	ATP-dependent helicase activity
AL538_RS15640	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL538_RS15645	COG1187	pseudouridine synthase activity
AL538_RS15655	COG1278	Cold shock
AL538_RS15665	COG0542	response to heat
AL538_RS15670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL538_RS15700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL538_RS15705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL538_RS15710	COG0297	glycogen (starch) synthase activity
AL538_RS15730	COG3070	regulator of competence-specific genes
AL538_RS15745	COG0745	RESPONSE REGULATOR receiver
AL538_RS15750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL538_RS15755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL538_RS15765	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL538_RS15770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL538_RS15790	COG4067	protein conserved in archaea
AL538_RS15790	COG0189	ligase activity
AL538_RS15810	COG1801	Protein of unknown function DUF72
AL538_RS15825	COG0840	transmembrane signaling receptor activity
AL538_RS15830	COG0632	four-way junction helicase activity
AL538_RS15840	COG1271	oxidase subunit
AL538_RS15845	COG1294	oxidase, subunit
AL538_RS15850	COG4890	Cyd operon protein YbgT
AL538_RS15860	COG0824	Thioesterase
AL538_RS15865	COG0811	peptide transport
AL538_RS15880	COG0823	Involved in the tonB-independent uptake of proteins
AL538_RS15885	COG2885	chlorophyll binding
AL538_RS15890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL538_RS15905	COG0673	inositol 2-dehydrogenase activity
AL538_RS15910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS15910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS15910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL538_RS15915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS15920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS15925	COG1882	Formate acetyltransferase
AL538_RS15930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL538_RS15940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL538_RS15945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS15950	COG2207	Transcriptional regulator
AL538_RS15955	COG0371	Dehydrogenase
AL538_RS15960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL538_RS15980	COG3766	membrane
AL538_RS15990	COG0754	glutathionylspermidine amidase activity
AL538_RS16000	COG0784	Response regulator, receiver
AL538_RS16000	COG5002	protein histidine kinase activity
AL538_RS16080	COG4669	(LipO)protein
AL538_RS16125	COG4792	protein secretion
AL538_RS16130	COG4791	protein targeting
AL538_RS16135	COG4794	Type iii secretion
AL538_RS16140	COG4790	Type iii secretion
AL538_RS16210	COG0457	Tetratricopeptide repeat
AL538_RS16225	COG0789	Transcriptional regulator
AL538_RS16230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL538_RS16245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS16245	COG1263	PTS System
AL538_RS16250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS16255	COG1621	beta-fructofuranosidase activity
AL538_RS16260	COG2824	Alkylphosphonate utilization operon protein PhnA
AL538_RS16275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL538_RS16300	COG0534	Mate efflux family protein
AL538_RS16305	COG0444	Belongs to the ABC transporter superfamily
AL538_RS16310	COG4608	Belongs to the ABC transporter superfamily
AL538_RS16315	COG0747	negative chemotaxis
AL538_RS16335	COG0583	DNA-binding transcription factor activity
AL538_RS16340	COG4771	TonB-dependent receptor
AL538_RS16360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS16365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS16375	COG2186	Transcriptional regulator
AL538_RS16390	COG1288	antiporter activity
AL538_RS16415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS16435	COG2176	DNA-directed DNA polymerase activity
AL538_RS16440	COG0517	IMP dehydrogenase activity
AL538_RS16445	COG2186	Transcriptional regulator
AL538_RS16450	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS16455	COG2186	Transcriptional regulator
AL538_RS16475	COG1917	Cupin 2, conserved barrel domain protein
AL538_RS16480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS16485	COG0800	Aldolase
AL538_RS16490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS16500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL538_RS16530	COG3568	Endonuclease Exonuclease Phosphatase
AL538_RS16540	COG4934	collagen metabolic process
AL538_RS16575	COG0686	Belongs to the AlaDH PNT family
AL538_RS16585	COG1674	ftsk spoiiie
AL538_RS16595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL538_RS16615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL538_RS16620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL538_RS16660	COG0300	oxidoreductase activity
AL538_RS16675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL538_RS16685	COG2268	Band 7 protein
AL538_RS16695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL538_RS16705	COG0482	sulfurtransferase activity
AL538_RS16715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS16725	COG1757	Na H antiporter
AL538_RS16740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL538_RS16745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL538_RS16750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL538_RS16750	COG0131	Imidazoleglycerol-phosphate dehydratase
AL538_RS16755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL538_RS16760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL538_RS16770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL538_RS16770	COG0140	phosphoribosyl-ATP diphosphatase activity
AL538_RS16775	COG3012	SEC-C Motif Domain Protein
AL538_RS16780	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL538_RS16785	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL538_RS16790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL538_RS16795	COG0215	cysteine-tRNA ligase activity
AL538_RS16800	COG1435	thymidine kinase activity
AL538_RS16805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL538_RS16830	COG2116	formate transmembrane transporter activity
AL538_RS16835	COG0390	transport system, permease component
AL538_RS16840	COG4459	periplasmic nitrate reductase
AL538_RS16845	COG3005	denitrification pathway
AL538_RS16850	COG0243	molybdopterin cofactor binding
AL538_RS16865	COG1121	(ABC) transporter
AL538_RS16870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL538_RS16875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL538_RS16880	COG1227	inorganic diphosphatase activity
AL538_RS16890	COG4172	Belongs to the ABC transporter superfamily
AL538_RS16900	COG4171	peptide transport system, permease
AL538_RS16915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL538_RS16920	COG1842	Phage shock protein A
AL538_RS16950	COG2818	Glycosylase
AL538_RS16955	COG5380	lipid catabolic process
AL538_RS16960	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL538_RS16965	COG0626	cystathionine gamma-synthase activity
AL538_RS16975	COG0733	neurotransmitter:sodium symporter activity
AL538_RS16985	COG0564	pseudouridine synthase activity
AL538_RS16995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL538_RS17000	COG1151	hydroxylamine reductase activity
AL538_RS17005	COG3604	Transcriptional regulator
AL538_RS17010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL538_RS17015	COG4136	ATPase activity
AL538_RS17020	COG4135	transport system, permease component
AL538_RS17025	COG4134	Bacterial extracellular solute-binding protein
AL538_RS17030	COG0398	Pfam SNARE associated Golgi protein
AL538_RS17040	COG0493	'glutamate synthase
AL538_RS17065	COG0659	secondary active sulfate transmembrane transporter activity
AL538_RS17075	COG3313	Fe-S protein
AL538_RS17135	COG1061	Type III restriction enzyme res subunit
AL538_RS17140	COG1187	pseudouridine synthase activity
AL538_RS17145	COG2814	Major facilitator Superfamily
AL538_RS17155	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS17165	COG1609	Transcriptional regulator
AL538_RS17170	COG0702	epimerase
AL538_RS17175	COG0534	Mate efflux family protein
AL538_RS17180	COG4181	ATPase activity
AL538_RS17210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL538_RS17220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL538_RS17230	COG1737	Transcriptional regulator
AL538_RS17235	COG0076	glutamate decarboxylase activity
AL538_RS17245	COG2431	L-lysine efflux transmembrane transporter activity
AL538_RS17260	COG3070	regulator of competence-specific genes
AL538_RS17275	COG4191	Histidine kinase
AL538_RS17275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS17285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL538_RS17295	COG5002	protein histidine kinase activity
AL538_RS17295	COG3447	MASE1 domain protein
AL538_RS17295	COG5001	Diguanylate cyclase
AL538_RS17315	COG0583	DNA-binding transcription factor activity
AL538_RS17320	COG2610	gluconate transmembrane transporter activity
AL538_RS17330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL538_RS17335	COG4988	ABC transporter
AL538_RS17340	COG0492	ferredoxin-NADP+ reductase activity
AL538_RS17360	COG3706	GGDEF domain
AL538_RS17365	COG0471	metal ion transport
AL538_RS17370	COG2949	membrane
AL538_RS17380	COG1643	Atp-dependent helicase
AL538_RS17425	COG0471	metal ion transport
AL538_RS17430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS17430	COG4191	Histidine kinase
AL538_RS17440	COG5001	Diguanylate cyclase
AL538_RS17440	COG3300	MHYT domain
AL538_RS17450	COG1280	lysine exporter protein (LysE YggA)
AL538_RS17455	COG1328	CTP reductase activity
AL538_RS17460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL538_RS17470	COG0861	Integral membrane protein TerC family
AL538_RS17480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL538_RS17490	COG3706	GGDEF domain
AL538_RS17500	COG1454	alcohol dehydrogenase
AL538_RS17505	COG0814	amino acid
AL538_RS17520	COG1120	ATPase activity
AL538_RS17525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL538_RS17530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL538_RS17535	COG4774	siderophore transport
AL538_RS17550	COG1132	(ABC) transporter
AL538_RS17555	COG1132	(ABC) transporter
AL538_RS17560	COG2165	general secretion pathway protein
AL538_RS17570	COG0583	DNA-binding transcription factor activity
AL538_RS17595	COG0443	Heat shock 70 kDa protein
AL538_RS17600	COG0443	Heat shock 70 kDa protein
AL538_RS17610	COG3706	GGDEF domain
AL538_RS17640	COG0243	molybdopterin cofactor binding
AL538_RS17645	COG0437	4 iron, 4 sulfur cluster binding
AL538_RS17650	COG3302	dmso reductase anchor subunit
AL538_RS17665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL538_RS17670	COG1643	Atp-dependent helicase
AL538_RS17695	COG3063	Type IV pilus biogenesis stability protein PilW
AL538_RS17720	COG0531	amino acid
AL538_RS17725	COG1280	lysine exporter protein (LysE YggA)
AL538_RS17730	COG0583	DNA-binding transcription factor activity
AL538_RS17735	COG1560	Kdo2-lipid A biosynthetic process
AL538_RS17750	COG1846	Transcriptional regulator
AL538_RS17760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL538_RS17765	COG2197	response regulator
AL538_RS17800	COG1280	lysine exporter protein (LysE YggA)
AL538_RS17815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS17820	COG2358	TRAP transporter, solute receptor (TAXI family
AL538_RS17825	COG0730	response to heat
AL538_RS17850	COG0456	acetyltransferase
AL538_RS17860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL538_RS17970	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL538_RS17975	COG0372	Belongs to the citrate synthase family
AL538_RS17985	COG2828	Protein conserved in bacteria
AL538_RS18010	COG0561	phosphatase activity
AL538_RS18015	COG0602	queuosine metabolic process
AL538_RS18025	COG2203	Gaf domain
AL538_RS18025	COG2199	diguanylate cyclase activity
AL538_RS18055	COG3064	Membrane
AL538_RS18065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL538_RS18075	COG0297	glycogen (starch) synthase activity
AL538_RS18115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL538_RS18125	COG0573	inorganic phosphate transmembrane transporter activity
AL538_RS18135	COG4191	Histidine kinase
AL538_RS18145	COG0110	maltose O-acetyltransferase activity
AL538_RS18180	COG0840	transmembrane signaling receptor activity
AL538_RS18185	COG0714	Associated with various cellular activities
AL538_RS18205	COG2304	oxidoreductase activity
AL538_RS18220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL538_RS18225	COG0581	inorganic phosphate transmembrane transporter activity
AL538_RS18230	COG0573	inorganic phosphate transmembrane transporter activity
AL538_RS18240	COG0840	transmembrane signaling receptor activity
AL538_RS18260	COG4771	TonB-dependent receptor
AL538_RS18265	COG1770	oligopeptidase
AL538_RS18275	COG0513	Belongs to the DEAD box helicase family
AL538_RS18285	COG1376	ErfK ybiS ycfS ynhG family protein
AL538_RS18285	COG1388	LysM domain
AL538_RS18290	COG0415	Belongs to the DNA photolyase family
AL538_RS18295	COG0789	Transcriptional regulator
AL538_RS18300	COG3272	Protein of unknown function (DUF1722)
AL538_RS18310	COG0813	purine-nucleoside phosphorylase activity
AL538_RS18340	COG1566	PFAM secretion protein HlyD family protein
AL538_RS18350	COG1122	ATPase activity
AL538_RS18370	COG0348	domain, Protein
AL538_RS18375	COG0437	4 iron, 4 sulfur cluster binding
AL538_RS18410	COG1067	ATP-dependent peptidase activity
AL538_RS18420	COG4172	Belongs to the ABC transporter superfamily
AL538_RS18425	COG1505	serine-type exopeptidase activity
AL538_RS18430	COG0583	DNA-binding transcription factor activity
AL538_RS18435	COG1620	l-lactate permease
AL538_RS18440	COG1304	FMN binding
AL538_RS18450	COG0668	transmembrane transport
AL538_RS18465	COG4948	Mandelate Racemase Muconate Lactonizing
AL538_RS18475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL538_RS18495	COG1342	Belongs to the UPF0251 family
AL538_RS18505	COG4176	ABC-type proline glycine betaine transport system permease component
AL538_RS18510	COG3448	diguanylate cyclase activity
AL538_RS18510	COG4175	Glycine betaine
AL538_RS18525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL538_RS18530	COG0589	response to stress
AL538_RS18535	COG0583	DNA-binding transcription factor activity
AL538_RS18585	COG1335	isochorismatase
AL538_RS18600	COG0753	catalase activity
AL538_RS18625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL538_RS18630	COG1263	PTS System
AL538_RS18630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS18635	COG1609	Transcriptional regulator
AL538_RS18640	COG1349	DNA-binding transcription factor activity
AL538_RS18645	COG0346	lactoylglutathione lyase activity
AL538_RS18650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL538_RS18650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL538_RS18660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS18660	COG1263	PTS System
AL538_RS18670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL538_RS18675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL538_RS18685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL538_RS18700	COG0561	phosphatase activity
AL538_RS18715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS18720	COG3537	Alpha-1,2-mannosidase
AL538_RS18725	COG3537	Alpha-1,2-mannosidase
AL538_RS18735	COG3537	Alpha-1,2-mannosidase
AL538_RS18740	COG3537	Alpha-1,2-mannosidase
AL538_RS18755	COG1280	lysine exporter protein (LysE YggA)
AL538_RS18760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL538_RS18775	COG3226	Transcriptional regulator
AL538_RS18780	COG0583	DNA-binding transcription factor activity
AL538_RS18795	COG0488	(ABC) transporter
AL538_RS18800	COG0435	Glutathione S-transferase
AL538_RS18805	COG0431	NADPH-dependent FMN reductase
AL538_RS18810	COG0583	DNA-binding transcription factor activity
AL538_RS18820	COG4628	conserved protein (DUF2132)
AL538_RS18825	COG0488	(ABC) transporter
AL538_RS18840	COG0346	lactoylglutathione lyase activity
AL538_RS18845	COG0384	phenazine biosynthesis protein PhzF
AL538_RS18860	COG3220	belongs to the UPF0276 family
AL538_RS18875	COG1271	oxidase subunit
AL538_RS18880	COG1294	oxidase, subunit
AL538_RS18925	COG2207	Transcriptional regulator
AL538_RS18935	COG1882	Formate acetyltransferase
AL538_RS18940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL538_RS18945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL538_RS18960	COG2205	protein histidine kinase activity
AL538_RS18965	COG0745	RESPONSE REGULATOR receiver
AL538_RS18975	COG0454	-acetyltransferase
AL538_RS18985	COG2814	Major facilitator Superfamily
AL538_RS19000	COG0583	DNA-binding transcription factor activity
AL538_RS19005	COG2988	succinylglutamate desuccinylase activity
AL538_RS19045	COG0628	permease
AL538_RS19050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL538_RS19065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL538_RS19075	COG4628	conserved protein (DUF2132)
AL538_RS19080	COG0583	DNA-binding transcription factor activity
AL538_RS19105	COG1686	Belongs to the peptidase S11 family
AL538_RS19120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL538_RS19140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL538_RS19145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL538_RS19160	COG0415	Belongs to the DNA photolyase family
AL538_RS19165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AL538_RS19175	COG4667	esterase of the alpha-beta hydrolase superfamily
AL538_RS19180	COG2095	MarC family integral membrane protein
AL538_RS19190	COG1596	polysaccharide export
AL538_RS19215	COG0583	DNA-binding transcription factor activity
AL538_RS19250	COG1301	dicarboxylic acid transport
AL538_RS19265	COG3339	Conserved Protein
AL538_RS19270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL538_RS19275	COG0700	Nucleoside recognition
AL538_RS19280	COG3366	ferrous iron transmembrane transporter activity
AL538_RS19295	COG0366	Alpha amylase catalytic
AL538_RS19300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL538_RS19305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL538_RS19310	COG1640	4-alpha-glucanotransferase
AL538_RS19320	COG0058	SHG alpha-glucan phosphorylase activity
AL538_RS19345	COG1999	signal sequence binding
AL538_RS19355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS19355	COG1263	PTS System
AL538_RS19360	COG1162	GTPase activity
AL538_RS19365	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL538_RS19370	COG0673	inositol 2-dehydrogenase activity
AL538_RS19395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS19400	COG0673	inositol 2-dehydrogenase activity
AL538_RS19405	COG3962	Belongs to the TPP enzyme family
AL538_RS19415	COG2814	Major facilitator Superfamily
AL538_RS19415	COG0477	Major facilitator Superfamily
AL538_RS19420	COG0583	DNA-binding transcription factor activity
AL538_RS19435	COG0183	Belongs to the thiolase family
AL538_RS19465	COG0531	amino acid
AL538_RS19470	COG1982	Orn Lys Arg decarboxylase major
AL538_RS19490	COG1929	Belongs to the glycerate kinase type-1 family
AL538_RS19495	COG3835	regulator
AL538_RS19505	COG1228	amidohydrolase
AL538_RS19530	COG0546	phosphoglycolate phosphatase activity
AL538_RS19580	COG1132	(ABC) transporter
AL538_RS19585	COG1132	(ABC) transporter
AL538_RS19590	COG4771	TonB-dependent receptor
AL538_RS19630	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AL538_RS19630	COG3408	Glycogen debranching enzyme
AL538_RS19650	COG2814	Major facilitator Superfamily
AL538_RS19665	COG2358	TRAP transporter, solute receptor (TAXI family
AL538_RS19670	COG3047	cAMP biosynthetic process
AL538_RS19675	COG1357	PFAM Pentapeptide repeats (8 copies)
AL538_RS19700	COG2076	Multidrug Resistance protein
AL538_RS19735	COG0583	DNA-binding transcription factor activity
AL538_RS19750	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL538_RS19765	COG3152	Membrane
AL538_RS19775	COG2199	diguanylate cyclase activity
AL538_RS19785	COG0561	phosphatase activity
AL538_RS19795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL538_RS19800	COG0564	pseudouridine synthase activity
AL538_RS19805	COG0534	Mate efflux family protein
AL538_RS19810	COG1609	Transcriptional regulator
AL538_RS19815	COG3842	ATPase activity
AL538_RS19820	COG2723	6-phospho-beta-galactosidase activity
AL538_RS19825	COG0395	ABC-type sugar transport system, permease component
AL538_RS19840	COG1609	Transcriptional regulator
AL538_RS19845	COG4580	involved in the transport of maltose and maltodextrins
AL538_RS19850	COG5001	Diguanylate cyclase
AL538_RS19915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL538_RS19925	COG0826	peptidase U32
AL538_RS19945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS19950	COG3716	PTS system mannose fructose sorbose family IID component
AL538_RS19960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL538_RS19965	COG2222	sugar isomerase
AL538_RS19975	COG1349	DNA-binding transcription factor activity
AL538_RS19980	COG1349	DNA-binding transcription factor activity
AL538_RS19990	COG1136	(ABC) transporter
AL538_RS19995	COG0577	efflux transmembrane transporter activity
AL538_RS20025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL538_RS20030	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL538_RS20040	COG2259	Doxx family
AL538_RS20080	COG3623	hexulose-6-phosphate isomerase
AL538_RS20085	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL538_RS20090	COG0561	phosphatase activity
AL538_RS20140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL538_RS20145	COG0251	oxidation-reduction process
AL538_RS20165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL538_RS20175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL538_RS20180	COG2207	Transcriptional regulator
AL538_RS20190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AL538_RS20195	COG0830	nickel cation binding
AL538_RS20200	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AL538_RS20205	COG0804	urea catabolic process
AL538_RS20210	COG0832	Belongs to the urease beta subunit family
AL538_RS20215	COG0831	urea catabolic process
AL538_RS20220	COG0829	nickel cation binding
AL538_RS20235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL538_RS20260	COG0786	glutamate:sodium symporter activity
AL538_RS20265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL538_RS20270	COG1131	(ABC) transporter
AL538_RS20285	COG0786	glutamate:sodium symporter activity
AL538_RS20310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL538_RS20315	COG3279	Response regulator of the LytR AlgR family
AL538_RS20320	COG3275	phosphorelay sensor kinase activity
AL538_RS20340	COG1136	(ABC) transporter
AL538_RS20350	COG0583	DNA-binding transcription factor activity
AL538_RS20355	COG1566	PFAM secretion protein HlyD family protein
AL538_RS20370	COG0772	Belongs to the SEDS family
AL538_RS20395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL538_RS20395	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AL538_RS20405	COG0444	Belongs to the ABC transporter superfamily
AL538_RS20410	COG4608	Belongs to the ABC transporter superfamily
AL538_RS20435	COG1444	tRNA N-acetyltransferase activity
AL538_RS20440	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL538_RS20445	COG0848	biopolymer transport protein
AL538_RS20485	COG1595	DNA-templated transcription, initiation
AL538_RS20515	COG4166	transmembrane transport
AL538_RS20585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL538_RS20640	COG1132	(ABC) transporter
AL538_RS20655	COG0516	GMP reductase activity
AL538_RS20655	COG0517	IMP dehydrogenase activity
AL538_RS20665	COG0641	radical SAM
AL538_RS20675	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AL538_RS20685	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AL538_RS20690	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS20695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS20700	COG0800	Aldolase
AL538_RS20715	COG3119	arylsulfatase activity
AL538_RS20720	COG2149	membrane
AL538_RS20745	COG2957	Belongs to the agmatine deiminase family
AL538_RS20750	COG0531	amino acid
AL538_RS20755	COG0549	Belongs to the carbamate kinase family
AL538_RS20770	COG0800	Aldolase
AL538_RS20775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS20780	COG1904	glucuronate isomerase
AL538_RS20785	COG0246	Mannitol dehydrogenase
AL538_RS20795	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL538_RS20805	COG2186	Transcriptional regulator
AL538_RS20810	COG1312	Catalyzes the dehydration of D-mannonate
AL538_RS20815	COG3655	Transcriptional regulator
AL538_RS20830	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL538_RS20835	COG1595	DNA-templated transcription, initiation
AL538_RS20840	COG0583	DNA-binding transcription factor activity
AL538_RS20855	COG0513	Belongs to the DEAD box helicase family
AL538_RS20860	COG3713	MltA-interacting MipA family protein
AL538_RS20870	COG2153	protein acetylation
AL538_RS20875	COG2258	MOSC domain
AL538_RS20890	COG1522	sequence-specific DNA binding
AL538_RS20900	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AL538_RS20915	COG0346	lactoylglutathione lyase activity
AL538_RS20960	COG0366	Alpha amylase catalytic
AL538_RS20965	COG0583	DNA-binding transcription factor activity
AL538_RS21015	COG3634	alkyl hydroperoxide reductase activity
AL538_RS21030	COG1846	Transcriptional regulator
AL538_RS21035	COG1764	response to oxidative stress
AL538_RS21050	COG0840	transmembrane signaling receptor activity
AL538_RS21055	COG0612	Peptidase, M16
AL538_RS21080	COG0739	heme binding
AL538_RS21105	COG4604	ABC transporter, ATP-binding protein
AL538_RS21110	COG4605	iron ion homeostasis
AL538_RS21115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL538_RS21120	COG4607	ABC-type enterochelin transport system periplasmic component
AL538_RS21125	COG0583	DNA-binding transcription factor activity
AL538_RS21130	COG4771	TonB-dependent receptor
AL538_RS21150	COG2814	Major facilitator Superfamily
AL538_RS21165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL538_RS21185	COG2199	diguanylate cyclase activity
AL538_RS21185	COG2203	Gaf domain
AL538_RS21210	COG0366	Alpha amylase catalytic
AL538_RS21215	COG2356	endonuclease I
AL538_RS21220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL538_RS21265	COG0456	acetyltransferase
AL538_RS21285	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS21295	COG3005	denitrification pathway
AL538_RS21300	COG0243	molybdopterin cofactor binding
AL538_RS21305	COG0671	phosphoesterase, PA-phosphatase related
AL538_RS21320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL538_RS21325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL538_RS21330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL538_RS21335	COG1116	anion transmembrane transporter activity
AL538_RS21340	COG0351	phosphomethylpyrimidine kinase
AL538_RS21345	COG0312	modulator of DNA gyrase
AL538_RS21350	COG0312	modulator of DNA gyrase
AL538_RS21465	COG1204	response to ionizing radiation
AL538_RS21475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL538_RS21485	COG0584	glycerophosphoryl diester phosphodiesterase
AL538_RS21490	COG0039	L-malate dehydrogenase activity
AL538_RS21495	COG0745	RESPONSE REGULATOR receiver
AL538_RS21515	COG0811	peptide transport
AL538_RS21520	COG0811	peptide transport
AL538_RS21525	COG0848	biopolymer transport protein
AL538_RS21570	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL538_RS21575	COG1121	(ABC) transporter
AL538_RS21580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL538_RS21595	COG1770	oligopeptidase
AL538_RS21600	COG2814	Major facilitator Superfamily
AL538_RS21605	COG0010	Belongs to the arginase family
AL538_RS21610	COG1166	arginine decarboxylase activity
AL538_RS21620	COG0189	ligase activity
AL538_RS21620	COG4067	protein conserved in archaea
AL538_RS21625	COG0189	ligase activity
AL538_RS21650	COG0583	DNA-binding transcription factor activity
AL538_RS21690	COG1114	Component of the transport system for branched-chain amino acids
AL538_RS21715	COG0579	oxidoreductase
AL538_RS21730	COG3033	Beta-eliminating lyase
AL538_RS21750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL538_RS21755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL538_RS21775	COG3706	GGDEF domain
AL538_RS21790	COG3706	GGDEF domain
AL538_RS21795	COG0415	Belongs to the DNA photolyase family
AL538_RS21800	COG3046	protein related to deoxyribodipyrimidine photolyase
AL538_RS21815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL538_RS21815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL538_RS21820	COG1765	OsmC-like protein
AL538_RS21870	COG1011	Hydrolase
AL538_RS21905	COG3240	lipase activity
AL538_RS21935	COG1609	Transcriptional regulator
AL538_RS21945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL538_RS21955	COG1840	ABC-type Fe3 transport system, periplasmic component
AL538_RS21960	COG3842	ATPase activity
AL538_RS21985	COG2990	Protein conserved in bacteria
AL538_RS21995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL538_RS22000	COG2866	Carboxypeptidase
AL538_RS22010	COG0583	DNA-binding transcription factor activity
AL538_RS22035	COG3104	oligopeptide transport
AL538_RS22040	COG1760	l-serine dehydratase
AL538_RS22065	COG0741	lytic transglycosylase activity
AL538_RS22065	COG1388	LysM domain
AL538_RS22085	COG1815	bacterial-type flagellum-dependent cell motility
AL538_RS22090	COG1558	bacterial-type flagellum-dependent cell motility
AL538_RS22100	COG1749	Flagellar hook protein flgE
AL538_RS22105	COG4787	bacterial-type flagellum-dependent cell motility
AL538_RS22110	COG4786	Flagellar basal body rod
AL538_RS22115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL538_RS22120	COG1706	bacterial-type flagellum-dependent cell motility
AL538_RS22130	COG4786	Flagellar basal body rod
AL538_RS22130	COG1256	bacterial-type flagellum assembly
AL538_RS22135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS22170	COG1253	flavin adenine dinucleotide binding
AL538_RS22175	COG3710	Transcriptional regulator
AL538_RS22190	COG2226	methyltransferase
AL538_RS22210	COG0672	)-iron permease
AL538_RS22225	COG0577	efflux transmembrane transporter activity
AL538_RS22225	COG1136	(ABC) transporter
AL538_RS22235	COG1136	(ABC) transporter
AL538_RS22250	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL538_RS22335	COG1360	Flagellar Motor Protein
AL538_RS22340	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL538_RS22345	COG1191	sigma factor activity
AL538_RS22350	COG1580	Controls the rotational direction of flagella during chemotaxis
AL538_RS22365	COG1516	flagellar protein fliS
AL538_RS22370	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL538_RS22380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL538_RS22395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL538_RS22405	COG1987	bacterial-type flagellum assembly
AL538_RS22465	COG2200	EAL domain
AL538_RS22510	COG0346	lactoylglutathione lyase activity
AL538_RS22535	COG0745	RESPONSE REGULATOR receiver
AL538_RS22560	COG0156	8-amino-7-oxononanoate synthase activity
AL538_RS22565	COG1063	alcohol dehydrogenase
AL538_RS22595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL538_RS22620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL538_RS22655	COG3338	carbonate dehydratase activity
AL538_RS22685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL538_RS22695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS22745	COG0318	PFAM AMP-dependent synthetase and ligase
AL538_RS22750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL538_RS22785	COG0786	glutamate:sodium symporter activity
AL538_RS22790	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL538_RS22795	COG1538	Outer membrane efflux protein
AL538_RS22805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS22810	COG0583	DNA-binding transcription factor activity
AL538_RS22825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL538_RS22830	COG2197	response regulator
AL538_RS22840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL538_RS22840	COG0574	Belongs to the PEP-utilizing enzyme family
AL538_RS22850	COG0252	asparaginase activity
AL538_RS22860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL538_RS22865	COG0583	DNA-binding transcription factor activity
AL538_RS22885	COG3122	Protein conserved in bacteria
AL538_RS22900	COG1902	pentaerythritol trinitrate reductase activity
AL538_RS22910	COG2814	Major facilitator Superfamily
AL538_RS22915	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS22940	COG0583	DNA-binding transcription factor activity
AL538_RS22950	COG0513	Belongs to the DEAD box helicase family
AL538_RS22970	COG0095	Lipoate-protein ligase
AL538_RS22990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL538_RS22995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL538_RS22995	COG2207	Transcriptional regulator
AL538_RS23000	COG0583	DNA-binding transcription factor activity
AL538_RS23010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL538_RS23045	COG1566	PFAM secretion protein HlyD family protein
AL538_RS23050	COG0583	DNA-binding transcription factor activity
AL538_RS23065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS23065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS23065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS23070	COG2207	Transcriptional regulator
AL538_RS23080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS23085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS23090	COG0583	DNA-binding transcription factor activity
AL538_RS23100	COG2084	Dehydrogenase
AL538_RS23105	COG0753	catalase activity
AL538_RS23115	COG2130	NADP-dependent
AL538_RS23120	COG1309	transcriptional regulator
AL538_RS23155	COG0438	transferase activity, transferring glycosyl groups
AL538_RS23165	COG0489	protein tyrosine kinase activity
AL538_RS23165	COG3206	protein involved in exopolysaccharide biosynthesis
AL538_RS23185	COG3842	ATPase activity
AL538_RS23200	COG1175	transmembrane transport
AL538_RS23205	COG3833	ABC-type maltose transport systems, permease component
AL538_RS23250	COG0741	lytic transglycosylase activity
AL538_RS23275	COG2354	Protein conserved in bacteria
AL538_RS23290	COG0401	homolog of Blt101
AL538_RS23295	COG0633	Ferredoxin
AL538_RS23295	COG3217	Mosc domain protein beta barrel domain protein
AL538_RS23295	COG0633	Ferredoxin
AL538_RS23295	COG3217	Mosc domain protein beta barrel domain protein
AL538_RS23305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL538_RS23345	COG0583	DNA-binding transcription factor activity
AL538_RS23365	COG2814	Major facilitator Superfamily
AL538_RS23375	COG1335	isochorismatase
AL538_RS23380	COG4977	sequence-specific DNA binding
AL538_RS23390	COG2194	sulfuric ester hydrolase activity
AL538_RS23395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL538_RS23405	COG2205	protein histidine kinase activity
AL538_RS23410	COG0745	RESPONSE REGULATOR receiver
AL538_RS23415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL538_RS23420	COG4948	Mandelate Racemase Muconate Lactonizing
AL538_RS23425	COG1053	succinate dehydrogenase
AL538_RS23425	COG3976	FMN-binding domain protein
AL538_RS23440	COG4221	oxidoreductase activity
AL538_RS23455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL538_RS23475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL538_RS23500	COG1418	mRNA catabolic process
AL538_RS23515	COG0402	S-adenosylhomocysteine deaminase activity
AL538_RS23520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL538_RS23525	COG2239	Acts as a magnesium transporter
AL538_RS23530	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL538_RS23535	COG1566	PFAM secretion protein HlyD family protein
AL538_RS23560	COG0745	RESPONSE REGULATOR receiver
AL538_RS23565	COG2205	protein histidine kinase activity
AL538_RS23575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL538_RS23580	COG0531	amino acid
AL538_RS23585	COG1522	sequence-specific DNA binding
AL538_RS23595	COG0583	DNA-binding transcription factor activity
AL538_RS23615	COG0784	Response regulator, receiver
AL538_RS23615	COG5002	protein histidine kinase activity
AL538_RS23615	COG2205	protein histidine kinase activity
AL538_RS23620	COG0673	inositol 2-dehydrogenase activity
AL538_RS23625	COG0534	Mate efflux family protein
AL538_RS23630	COG2926	Belongs to the UPF0265 family
AL538_RS23700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL538_RS23705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL538_RS23715	COG1280	lysine exporter protein (LysE YggA)
AL538_RS23725	COG0183	Belongs to the thiolase family
AL538_RS23750	COG3005	denitrification pathway
AL538_RS23770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL538_RS23775	COG3850	Histidine kinase
AL538_RS23780	COG2197	response regulator
AL538_RS23795	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL538_RS23815	COG0840	transmembrane signaling receptor activity
AL538_RS23825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL538_RS23855	COG0545	Peptidyl-prolyl cis-trans isomerase
AL538_RS23885	COG1278	Cold shock
AL538_RS23890	COG3036	rescue of stalled ribosome
AL538_RS23900	COG2199	diguanylate cyclase activity
AL538_RS23915	COG1136	(ABC) transporter
AL538_RS23915	COG0577	efflux transmembrane transporter activity
AL538_RS23920	COG1136	(ABC) transporter
AL538_RS23920	COG0577	efflux transmembrane transporter activity
AL538_RS23950	COG1538	Outer membrane efflux protein
AL538_RS23955	COG0784	Response regulator, receiver
AL538_RS23955	COG2205	protein histidine kinase activity
AL538_RS23980	COG0840	transmembrane signaling receptor activity
AL538_RS23985	COG0783	Belongs to the Dps family
AL538_RS23995	COG1619	proteins homologs of microcin C7 resistance protein MccF
AL538_RS24000	COG2133	pyrroloquinoline quinone binding
AL538_RS24005	COG1454	alcohol dehydrogenase
AL538_RS24015	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL538_RS24035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL538_RS24040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL538_RS24050	COG3186	Phenylalanine-4-hydroxylase
AL538_RS24090	COG3530	Putative quorum-sensing-regulated virulence factor
AL538_RS24125	COG1289	transmembrane transporter activity
AL538_RS24130	COG0210	DNA helicase
AL538_RS24140	COG1879	ABC-type sugar transport system periplasmic component
AL538_RS24145	COG2205	protein histidine kinase activity
AL538_RS24145	COG2198	Histidine kinase
AL538_RS24145	COG0784	Response regulator, receiver
AL538_RS24175	COG3119	arylsulfatase activity
AL538_RS24180	COG3119	arylsulfatase activity
AL538_RS24190	COG0583	DNA-binding transcription factor activity
AL538_RS24195	COG3119	arylsulfatase activity
AL538_RS24200	COG0641	radical SAM
AL538_RS24205	COG0714	Associated with various cellular activities
AL538_RS24265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL538_RS24275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL538_RS24285	COG0583	DNA-binding transcription factor activity
AL538_RS24290	COG1597	lipid kinase activity
AL538_RS24295	COG3111	PFAM Bacterial OB fold (BOF) protein
AL538_RS24315	COG0641	radical SAM
AL538_RS24340	COG0501	Belongs to the peptidase M48B family
AL538_RS24345	COG1704	LemA family
AL538_RS24350	COG3069	C4-dicarboxylate transmembrane transporter activity
AL538_RS24380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL538_RS24385	COG0739	heme binding
AL538_RS24425	COG3501	Rhs element vgr protein
AL538_RS24450	COG0515	serine threonine protein kinase
AL538_RS24485	COG1522	sequence-specific DNA binding
AL538_RS24545	COG0457	Tetratricopeptide repeat
AL538_RS24550	COG0477	Major facilitator Superfamily
AL538_RS24550	COG2814	Major facilitator Superfamily
AL538_RS24555	COG1940	carbohydrate kinase activity
AL538_RS24560	COG2017	converts alpha-aldose to the beta-anomer
AL538_RS24565	COG0019	diaminopimelate decarboxylase activity
AL538_RS24570	COG4264	IucA IucC family
AL538_RS24595	COG4772	TonB-dependent receptor
AL538_RS24600	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL538_RS24605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL538_RS24610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL538_RS24615	COG1120	ATPase activity
AL538_RS24620	COG4771	TonB-dependent receptor
AL538_RS24635	COG0784	Response regulator, receiver
AL538_RS24635	COG2205	protein histidine kinase activity
AL538_RS24640	COG5001	Diguanylate cyclase
AL538_RS24640	COG3300	MHYT domain
AL538_RS24645	COG2197	response regulator
AL538_RS24650	COG3706	GGDEF domain
AL538_RS24660	COG2197	response regulator
AL538_RS24670	COG0778	Nitroreductase
AL538_RS24680	COG0835	chemotaxis
AL538_RS24680	COG0784	Response regulator, receiver
AL538_RS24685	COG2165	general secretion pathway protein
AL538_RS24695	COG2962	Rard protein
AL538_RS24720	COG3278	Belongs to the heme-copper respiratory oxidase family
AL538_RS24745	COG1024	Enoyl-CoA hydratase
AL538_RS24750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL538_RS24755	COG1960	acyl-CoA dehydrogenase activity
AL538_RS24765	COG0183	Belongs to the thiolase family
AL538_RS24780	COG1024	Enoyl-CoA hydratase
AL538_RS24785	COG1024	Enoyl-CoA hydratase
AL538_RS24795	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS24800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL538_RS24805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL538_RS24810	COG1845	cytochrome c oxidase, subunit III
AL538_RS24815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL538_RS24825	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL538_RS24825	COG1902	pentaerythritol trinitrate reductase activity
AL538_RS24830	COG0671	phosphoesterase, PA-phosphatase related
AL538_RS24875	COG1132	(ABC) transporter
AL538_RS24890	COG1733	regulation of RNA biosynthetic process
AL538_RS24900	COG2176	DNA-directed DNA polymerase activity
AL538_RS24970	COG0509	glycine decarboxylation via glycine cleavage system
AL538_RS24975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL538_RS24985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL538_RS24995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS25000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL538_RS25030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL538_RS25030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS25030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS25035	COG1105	Belongs to the carbohydrate kinase PfkB family
AL538_RS25040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS25040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS25045	COG1609	Transcriptional regulator
AL538_RS25060	COG2203	Gaf domain
AL538_RS25060	COG2200	EAL domain
AL538_RS25060	COG2199	diguanylate cyclase activity
AL538_RS25065	COG0765	amino acid transport
AL538_RS25070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS25075	COG0765	amino acid transport
AL538_RS25080	COG1126	abc transporter atp-binding protein
AL538_RS25090	COG1979	alcohol dehydrogenase
AL538_RS25095	COG2207	Transcriptional regulator
AL538_RS25105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL538_RS25115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS25130	COG3437	response regulator, receiver
AL538_RS25130	COG0784	Response regulator, receiver
AL538_RS25135	COG0546	phosphoglycolate phosphatase activity
AL538_RS25160	COG0513	Belongs to the DEAD box helicase family
AL538_RS25165	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL538_RS25180	COG3038	cytochrome b561
AL538_RS25190	COG2116	formate transmembrane transporter activity
AL538_RS25200	COG0583	DNA-binding transcription factor activity
AL538_RS25210	COG3593	DNA synthesis involved in DNA repair
AL538_RS25215	COG0737	Belongs to the 5'-nucleotidase family
AL538_RS25235	COG0646	methionine synthase
AL538_RS25235	COG1410	methionine synthase
AL538_RS25250	COG2267	carboxylic ester hydrolase activity
AL538_RS25255	COG2067	long-chain fatty acid transport protein
AL538_RS25270	COG2050	protein possibly involved in aromatic compounds catabolism
AL538_RS25280	COG4533	DNA binding
AL538_RS25305	COG0484	heat shock protein binding
AL538_RS25315	COG5001	Diguanylate cyclase
AL538_RS25315	COG3300	MHYT domain
AL538_RS25320	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL538_RS25330	COG4181	ATPase activity
AL538_RS25335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL538_RS25345	COG1984	allophanate hydrolase subunit 2
AL538_RS25350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL538_RS25360	COG5002	protein histidine kinase activity
AL538_RS25360	COG5001	Diguanylate cyclase
AL538_RS25360	COG3447	MASE1 domain protein
AL538_RS25365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL538_RS25380	COG0583	DNA-binding transcription factor activity
AL538_RS25390	COG0045	succinate-CoA ligase (ADP-forming) activity
AL538_RS25390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL538_RS25390	COG1042	CoA-binding domain protein
AL538_RS25410	COG0023	Translation Initiation Factor
AL538_RS25445	COG3140	Belongs to the UPF0181 family
AL538_RS25470	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL538_RS25475	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL538_RS25505	COG4251	negative regulation of phosphorylation
AL538_RS25505	COG3706	GGDEF domain
AL538_RS25505	COG2203	Gaf domain
AL538_RS25505	COG5001	Diguanylate cyclase
AL538_RS25515	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL538_RS25520	COG4149	molybdate abc transporter
AL538_RS25525	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL538_RS25535	COG3111	PFAM Bacterial OB fold (BOF) protein
AL538_RS25545	COG0189	ligase activity
AL538_RS25545	COG4067	protein conserved in archaea
AL538_RS25560	COG0534	Mate efflux family protein
AL538_RS25565	COG0602	queuosine metabolic process
AL538_RS25570	COG1328	CTP reductase activity
AL538_RS25635	COG2197	response regulator
AL538_RS25640	COG3851	Histidine kinase
AL538_RS25645	COG2271	Major facilitator Superfamily
AL538_RS25650	COG1482	cell wall glycoprotein biosynthetic process
AL538_RS25660	COG0628	permease
AL538_RS25670	COG1566	PFAM secretion protein HlyD family protein
AL538_RS25695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL538_RS25700	COG3118	belongs to the thioredoxin family
AL538_RS25710	COG2205	protein histidine kinase activity
AL538_RS25710	COG3292	Two component regulator propeller
AL538_RS25710	COG0745	RESPONSE REGULATOR receiver
AL538_RS25745	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL538_RS25765	COG2116	formate transmembrane transporter activity
AL538_RS25775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL538_RS25780	COG5001	Diguanylate cyclase
AL538_RS25855	COG0277	FAD linked oxidase domain protein
AL538_RS25860	COG0583	DNA-binding transcription factor activity
AL538_RS25870	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL538_RS25885	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL538_RS25895	COG1288	antiporter activity
AL538_RS25905	COG2814	Major facilitator Superfamily
AL538_RS25915	COG3040	lipid binding
AL538_RS25950	COG3469	chitinase activity
AL538_RS25960	COG0419	ATPase involved in DNA repair
AL538_RS25965	COG0420	3'-5' exonuclease activity
AL538_RS25990	COG3209	COG3209 Rhs family protein
AL538_RS26060	COG0631	protein serine/threonine phosphatase activity
AL538_RS26095	COG2815	serine threonine protein kinase
AL538_RS26095	COG0515	serine threonine protein kinase
AL538_RS26120	COG0346	lactoylglutathione lyase activity
AL538_RS26125	COG1902	pentaerythritol trinitrate reductase activity
AL538_RS26135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AL538_RS26135	COG2755	lipolytic protein G-D-S-L family
AL538_RS26145	COG5642	Protein of unknown function (DUF2384)
AL538_RS26160	COG1234	tRNA 3'-trailer cleavage
AL538_RS26165	COG2067	long-chain fatty acid transport protein
AL538_RS26245	COG1024	Enoyl-CoA hydratase
AL538_RS26250	COG0628	permease
AL538_RS26275	COG3038	cytochrome b561
AL538_RS26285	COG0739	heme binding
AL538_RS26335	COG2146	nitrite reductase [NAD(P)H] activity
AL538_RS26335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL538_RS26340	COG1116	anion transmembrane transporter activity
AL538_RS26345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL538_RS26350	COG1116	anion transmembrane transporter activity
AL538_RS26350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL538_RS26375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL538_RS26375	COG1648	precorrin-2 dehydrogenase activity
AL538_RS26380	COG0243	molybdopterin cofactor binding
AL538_RS26385	COG0456	acetyltransferase
AL538_RS26390	COG5002	protein histidine kinase activity
AL538_RS26390	COG5001	Diguanylate cyclase
AL538_RS26395	COG0814	amino acid
AL538_RS26405	COG3706	GGDEF domain
AL538_RS26425	COG1785	Belongs to the alkaline phosphatase family
AL538_RS26440	COG0745	RESPONSE REGULATOR receiver
AL538_RS26470	COG2847	Copper chaperone PCu(A)C
AL538_RS26475	COG0443	Heat shock 70 kDa protein
AL538_RS26525	COG1053	succinate dehydrogenase
AL538_RS26525	COG3976	FMN-binding domain protein
AL538_RS26525	COG0431	NADPH-dependent FMN reductase
AL538_RS26530	COG5002	protein histidine kinase activity
AL538_RS26565	COG4160	amino acid transport
AL538_RS26570	COG4215	(ABC) transporter
AL538_RS26575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL538_RS26580	COG1126	abc transporter atp-binding protein
AL538_RS26615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL538_RS26625	COG1012	belongs to the aldehyde dehydrogenase family
AL538_RS26635	COG0583	DNA-binding transcription factor activity
AL538_RS26640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL538_RS26645	COG0513	Belongs to the DEAD box helicase family
AL538_RS26650	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL538_RS26665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL538_RS26705	COG5290	Psort location Cytoplasmic, score
AL538_RS26735	COG2205	protein histidine kinase activity
AL538_RS26740	COG0745	RESPONSE REGULATOR receiver
AL538_RS26745	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL538_RS26750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL538_RS26760	COG1119	ATPase activity
AL538_RS26765	COG2200	EAL domain
AL538_RS26765	COG2771	luxR family
AL538_RS26785	COG0513	Belongs to the DEAD box helicase family
AL538_RS26790	COG5001	Diguanylate cyclase
AL538_RS26790	COG5002	protein histidine kinase activity
AL538_RS26790	COG3447	MASE1 domain protein
AL538_RS26795	COG0523	cobalamin synthesis protein
AL538_RS26820	COG4206	TonB-dependent receptor
AL538_RS26830	COG0789	Transcriptional regulator
AL538_RS26835	COG4604	ABC transporter, ATP-binding protein
AL538_RS26840	COG4605	iron ion homeostasis
AL538_RS26845	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL538_RS26850	COG4607	ABC-type enterochelin transport system periplasmic component
AL538_RS26865	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL538_RS26880	COG1609	Transcriptional regulator
AL538_RS26885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS26890	COG1879	ABC-type sugar transport system periplasmic component
AL538_RS26895	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL538_RS26900	COG1129	ABC transporter
AL538_RS26910	COG5001	Diguanylate cyclase
AL538_RS26915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL538_RS26920	COG1794	racemase activity, acting on amino acids and derivatives
AL538_RS26935	COG3385	transposase activity
AL538_RS26950	COG0586	Pfam SNARE associated Golgi protein
AL538_RS26995	COG0784	Response regulator, receiver
AL538_RS26995	COG2205	protein histidine kinase activity
AL538_RS27005	COG0784	Response regulator, receiver
AL538_RS27005	COG2205	protein histidine kinase activity
AL538_RS27025	COG0330	HflC and HflK could
AL538_RS27040	COG4175	Glycine betaine
AL538_RS27040	COG0517	IMP dehydrogenase activity
AL538_RS27045	COG4176	ABC-type proline glycine betaine transport system permease component
AL538_RS27085	COG0402	S-adenosylhomocysteine deaminase activity
AL538_RS27100	COG0204	Acyl-transferase
AL538_RS27130	COG2885	chlorophyll binding
AL538_RS27170	COG0455	bacterial-type flagellum organization
AL538_RS27180	COG4964	Belongs to the GSP D family
AL538_RS27200	COG0583	DNA-binding transcription factor activity
AL538_RS27205	COG1073	alpha beta
AL538_RS27220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL538_RS27220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL538_RS27235	COG4989	oxidoreductase activity
AL538_RS27260	COG1914	H( )-stimulated, divalent metal cation uptake system
AL538_RS27280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL538_RS27300	COG2897	thiosulfate sulfurtransferase activity
AL538_RS27330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL538_RS27340	COG2814	Major facilitator Superfamily
AL538_RS27345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL538_RS27360	COG1612	heme a metabolic process
AL538_RS27380	COG1845	cytochrome c oxidase, subunit III
AL538_RS27385	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AL538_RS27395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL538_RS27400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL538_RS27410	COG1280	lysine exporter protein (LysE YggA)
AL538_RS27430	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL538_RS27445	COG0697	spore germination
AL538_RS27465	COG2814	Major facilitator Superfamily
AL538_RS27470	COG0583	DNA-binding transcription factor activity
AL538_RS27475	COG5001	Diguanylate cyclase
AL538_RS27480	COG0739	heme binding
AL538_RS27505	COG3314	Sporulation integral membrane protein YlbJ
AL538_RS27520	COG0814	amino acid
AL538_RS27540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL538_RS27545	COG1072	(Pantothenic acid kinase))
AL538_RS27555	COG1063	alcohol dehydrogenase
AL538_RS27560	COG2213	PTS system mannitol-specific
AL538_RS27565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS27570	COG2188	Transcriptional regulator
AL538_RS27575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS27575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL538_RS27575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL538_RS27580	COG0383	alpha-mannosidase activity
AL538_RS27585	COG1482	cell wall glycoprotein biosynthetic process
AL538_RS27590	COG0747	negative chemotaxis
AL538_RS27600	COG1733	regulation of RNA biosynthetic process
AL538_RS27615	COG0798	PFAM Bile acid sodium symporter
AL538_RS27630	COG1881	PFAM PEBP family protein
AL538_RS27640	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL538_RS27655	COG0583	DNA-binding transcription factor activity
AL538_RS27705	COG0366	Alpha amylase catalytic
AL538_RS27720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL538_RS27725	COG0835	chemotaxis
AL538_RS27725	COG0784	Response regulator, receiver
AL538_RS27735	COG0748	coenzyme F420 binding
AL538_RS27740	COG3721	Heme iron utilization protein
AL538_RS27750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL538_RS27755	COG0811	peptide transport
AL538_RS27760	COG0848	biopolymer transport protein
AL538_RS27770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL538_RS27775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL538_RS27780	COG0840	transmembrane signaling receptor activity
AL538_RS27790	COG1131	(ABC) transporter
AL538_RS27795	COG0842	Transport permease protein
AL538_RS27800	COG0251	oxidation-reduction process
AL538_RS27815	COG0800	Aldolase
AL538_RS27820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL538_RS27825	COG4145	pantothenate transmembrane transporter activity
AL538_RS27835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AL538_RS27860	COG3383	formate dehydrogenase (NAD+) activity
AL538_RS27880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL538_RS27905	COG3321	synthase
AL538_RS27905	COG0604	alcohol dehydrogenase
AL538_RS27905	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS27920	COG0456	acetyltransferase
AL538_RS27940	COG0612	Peptidase, M16
AL538_RS27945	COG4178	(ABC) transporter
AL538_RS27950	COG4771	TonB-dependent receptor
AL538_RS27960	COG0811	peptide transport
AL538_RS27965	COG0811	peptide transport
AL538_RS27970	COG0848	biopolymer transport protein
AL538_RS27995	COG1858	cytochrome C peroxidase
AL538_RS28005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL538_RS28015	COG1505	serine-type exopeptidase activity
AL538_RS28020	COG0488	(ABC) transporter
AL538_RS28025	COG1720	tRNA m6t6A37 methyltransferase activity
AL538_RS28045	COG2814	Major facilitator Superfamily
AL538_RS28060	COG0583	DNA-binding transcription factor activity
AL538_RS28065	COG0589	response to stress
AL538_RS28090	COG1175	transmembrane transport
AL538_RS28095	COG0395	ABC-type sugar transport system, permease component
AL538_RS28100	COG3842	ATPase activity
AL538_RS28130	COG0523	cobalamin synthesis protein
AL538_RS28140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AL538_RS28150	COG4667	esterase of the alpha-beta hydrolase superfamily
AL538_RS28155	COG1741	Belongs to the pirin family
AL538_RS28160	COG1278	Cold shock
AL538_RS28175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL538_RS28205	COG2226	methyltransferase
AL538_RS28215	COG3706	GGDEF domain
AL538_RS28220	COG1686	Belongs to the peptidase S11 family
AL538_RS28230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL538_RS28235	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL538_RS28240	COG0583	DNA-binding transcription factor activity
AL538_RS28245	COG0625	glutathione transferase activity
AL538_RS28255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL538_RS28280	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS28305	COG3746	phosphate-selective porin O and P
AL538_RS28315	COG3423	Transcriptional regulator
AL538_RS28320	COG2801	Transposase and inactivated derivatives
AL538_RS28325	COG2842	Transposition protein
AL538_RS28400	COG5566	PFAM Mor transcription activator
AL538_RS28430	COG0640	Transcriptional regulator
AL538_RS28440	COG4373	Mu-like prophage FluMu protein gp28
AL538_RS28445	COG4383	Mu-like prophage protein gp29
AL538_RS28465	COG4388	Caudovirus prohead serine protease
AL538_RS28475	COG4397	Mu-like prophage major head subunit gpT
AL538_RS28485	COG4387	Mu-like prophage protein GP36
AL538_RS28555	COG1028	Short-chain dehydrogenase reductase Sdr
AL538_RS28565	COG1301	dicarboxylic acid transport
AL538_RS28570	COG1252	NADH dehydrogenase
AL538_RS28580	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AL538_RS28585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity