locus-tag	class	description
C1S74_RS00015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1S74_RS00040	COG1846	Transcriptional regulator
C1S74_RS00045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S74_RS00050	COG0840	transmembrane signaling receptor activity
C1S74_RS00070	COG1448	Aminotransferase
C1S74_RS00075	COG3437	response regulator, receiver
C1S74_RS00075	COG2770	Histidine kinase
C1S74_RS00090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S74_RS00105	COG0017	Asparaginyl-tRNA synthetase
C1S74_RS00115	COG0720	synthase
C1S74_RS00120	COG2197	response regulator
C1S74_RS00130	COG5001	Diguanylate cyclase
C1S74_RS00130	COG3300	MHYT domain
C1S74_RS00135	COG1760	l-serine dehydratase
C1S74_RS00140	COG0814	amino acid
C1S74_RS00145	COG0494	nUDIX hydrolase
C1S74_RS00155	COG2205	protein histidine kinase activity
C1S74_RS00155	COG0784	Response regulator, receiver
C1S74_RS00160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1S74_RS00175	COG3106	COG3106 Predicted ATPase
C1S74_RS00190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S74_RS00310	COG1335	isochorismatase
C1S74_RS00640	COG2026	Addiction module toxin, RelE StbE family
C1S74_RS01105	COG2161	toxin-antitoxin pair type II binding
C1S74_RS01110	COG4115	mRNA cleavage
C1S74_RS01130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S74_RS01205	COG3177	Filamentation induced by cAMP protein fic
C1S74_RS01470	COG2732	(Barnase) inhibitor
C1S74_RS01650	COG3340	Belongs to the peptidase S51 family
C1S74_RS01675	COG0456	acetyltransferase
C1S74_RS01680	COG0471	metal ion transport
C1S74_RS01685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S74_RS01685	COG4191	Histidine kinase
C1S74_RS01695	COG3300	MHYT domain
C1S74_RS01695	COG5001	Diguanylate cyclase
C1S74_RS01705	COG1280	lysine exporter protein (LysE YggA)
C1S74_RS01710	COG1328	CTP reductase activity
C1S74_RS01715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1S74_RS01725	COG0861	Integral membrane protein TerC family
C1S74_RS01735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S74_RS01740	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS01745	COG3706	GGDEF domain
C1S74_RS01760	COG0814	amino acid
C1S74_RS01775	COG1120	ATPase activity
C1S74_RS01780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1S74_RS01790	COG4774	siderophore transport
C1S74_RS01800	COG1132	(ABC) transporter
C1S74_RS01805	COG1132	(ABC) transporter
C1S74_RS01810	COG2165	general secretion pathway protein
C1S74_RS01815	COG0583	DNA-binding transcription factor activity
C1S74_RS01840	COG0443	Heat shock 70 kDa protein
C1S74_RS01845	COG0443	Heat shock 70 kDa protein
C1S74_RS01885	COG3227	Zinc metalloprotease (Elastase)
C1S74_RS01895	COG0243	molybdopterin cofactor binding
C1S74_RS01900	COG0437	4 iron, 4 sulfur cluster binding
C1S74_RS01905	COG3302	dmso reductase anchor subunit
C1S74_RS01920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1S74_RS01925	COG1643	Atp-dependent helicase
C1S74_RS01950	COG3063	Type IV pilus biogenesis stability protein PilW
C1S74_RS01955	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1S74_RS01980	COG0531	amino acid
C1S74_RS01985	COG1280	lysine exporter protein (LysE YggA)
C1S74_RS01990	COG1560	Kdo2-lipid A biosynthetic process
C1S74_RS02000	COG1846	Transcriptional regulator
C1S74_RS02010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1S74_RS02015	COG1280	lysine exporter protein (LysE YggA)
C1S74_RS02030	COG1115	amino acid carrier protein
C1S74_RS02055	COG1368	sulfuric ester hydrolase activity
C1S74_RS02060	COG0215	cysteine-tRNA ligase activity
C1S74_RS02065	COG0534	Mate efflux family protein
C1S74_RS02070	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C1S74_RS02080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S74_RS02085	COG0456	acetyltransferase
C1S74_RS02090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1S74_RS02095	COG0662	Cupin 2, conserved barrel domain protein
C1S74_RS02100	COG0527	aspartate kinase activity
C1S74_RS02105	COG1858	cytochrome C peroxidase
C1S74_RS02110	COG1404	Belongs to the peptidase S8 family
C1S74_RS02160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1S74_RS02190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS02205	COG3976	FMN-binding domain protein
C1S74_RS02205	COG0431	NADPH-dependent FMN reductase
C1S74_RS02205	COG1053	succinate dehydrogenase
C1S74_RS02225	COG3290	protein histidine kinase activity
C1S74_RS02230	COG4565	transcriptional regulatory protein
C1S74_RS02235	COG4774	siderophore transport
C1S74_RS02245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1S74_RS02250	COG0363	glucosamine-6-phosphate deaminase activity
C1S74_RS02255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1S74_RS02275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S74_RS02385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1S74_RS02390	COG0372	Belongs to the citrate synthase family
C1S74_RS02400	COG2828	Protein conserved in bacteria
C1S74_RS02425	COG0561	phosphatase activity
C1S74_RS02430	COG0602	queuosine metabolic process
C1S74_RS02440	COG3706	GGDEF domain
C1S74_RS02485	COG0840	transmembrane signaling receptor activity
C1S74_RS02490	COG1254	Belongs to the acylphosphatase family
C1S74_RS02495	COG2920	part of a sulfur-relay system
C1S74_RS02505	COG0670	Belongs to the BI1 family
C1S74_RS02510	COG1126	abc transporter atp-binding protein
C1S74_RS02515	COG0765	amino acid transport
C1S74_RS02520	COG4597	amino acid ABC transporter
C1S74_RS02525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S74_RS02545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1S74_RS02575	COG3008	intermembrane lipid transfer
C1S74_RS02580	COG2995	paraquat-inducible protein a
C1S74_RS02585	COG1132	(ABC) transporter
C1S74_RS02590	COG1956	GAF domain-containing protein
C1S74_RS02595	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1S74_RS02610	COG0308	aminopeptidase N
C1S74_RS02620	COG2902	Dehydrogenase
C1S74_RS02645	COG0488	(ABC) transporter
C1S74_RS02665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1S74_RS02670	COG1067	ATP-dependent peptidase activity
C1S74_RS02675	COG3120	sequence-specific DNA binding
C1S74_RS02700	COG0784	Response regulator, receiver
C1S74_RS02700	COG2205	protein histidine kinase activity
C1S74_RS02715	COG3278	Belongs to the heme-copper respiratory oxidase family
C1S74_RS02730	COG2010	Cytochrome c
C1S74_RS02740	COG2217	Heavy metal translocating P-type atpase
C1S74_RS02755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S74_RS02785	COG3842	ATPase activity
C1S74_RS02795	COG1177	transmembrane transport
C1S74_RS02805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1S74_RS02810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1S74_RS02830	COG0437	4 iron, 4 sulfur cluster binding
C1S74_RS02835	COG0243	molybdopterin cofactor binding
C1S74_RS02835	COG3383	formate dehydrogenase (NAD+) activity
C1S74_RS02845	COG3381	protein complex oligomerization
C1S74_RS02865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1S74_RS02870	COG0488	(ABC) transporter
C1S74_RS02890	COG4191	Histidine kinase
C1S74_RS02895	COG2204	response regulator
C1S74_RS02905	COG4662	Binding-protein-dependent transport system inner membrane component
C1S74_RS02910	COG3842	ATPase activity
C1S74_RS02920	COG0303	'Molybdopterin
C1S74_RS02935	COG1940	carbohydrate kinase activity
C1S74_RS02940	COG3148	PFAM DTW domain containing protein
C1S74_RS02990	COG0840	transmembrane signaling receptor activity
C1S74_RS02995	COG0791	NLP P60 protein
C1S74_RS03005	COG3706	GGDEF domain
C1S74_RS03010	COG2201	protein-glutamate methylesterase activity
C1S74_RS03015	COG3001	Fructosamine kinase
C1S74_RS03025	COG0307	riboflavin synthase, alpha
C1S74_RS03030	COG0534	Mate efflux family protein
C1S74_RS03035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S74_RS03045	COG0456	acetyltransferase
C1S74_RS03065	COG0730	response to heat
C1S74_RS03070	COG2358	TRAP transporter, solute receptor (TAXI family
C1S74_RS03075	COG1012	belongs to the aldehyde dehydrogenase family
C1S74_RS03080	COG3284	Transcriptional regulator
C1S74_RS03090	COG1793	dna ligase
C1S74_RS03100	COG2885	chlorophyll binding
C1S74_RS03120	COG2204	response regulator
C1S74_RS03130	COG0438	transferase activity, transferring glycosyl groups
C1S74_RS03165	COG1215	transferase activity, transferring glycosyl groups
C1S74_RS03170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1S74_RS03180	COG3064	Membrane
C1S74_RS03205	COG2203	Gaf domain
C1S74_RS03205	COG2199	diguanylate cyclase activity
C1S74_RS03210	COG4999	Histidine kinase
C1S74_RS03210	COG3850	Histidine kinase
C1S74_RS03210	COG3437	response regulator, receiver
C1S74_RS03210	COG2205	protein histidine kinase activity
C1S74_RS03225	COG0110	maltose O-acetyltransferase activity
C1S74_RS03250	COG2315	Protein conserved in bacteria
C1S74_RS03255	COG1846	Transcriptional regulator
C1S74_RS03265	COG3247	response to pH
C1S74_RS03270	COG0668	transmembrane transport
C1S74_RS03285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C1S74_RS03300	COG0745	RESPONSE REGULATOR receiver
C1S74_RS03365	COG0519	Catalyzes the synthesis of GMP from XMP
C1S74_RS03375	COG0438	transferase activity, transferring glycosyl groups
C1S74_RS03390	COG0668	transmembrane transport
C1S74_RS03415	COG0625	glutathione transferase activity
C1S74_RS03425	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1S74_RS03440	COG2205	protein histidine kinase activity
C1S74_RS03445	COG0745	RESPONSE REGULATOR receiver
C1S74_RS03455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS03465	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1S74_RS03495	COG0813	purine-nucleoside phosphorylase activity
C1S74_RS03510	COG1451	nucleotide metabolic process
C1S74_RS03520	COG0583	DNA-binding transcription factor activity
C1S74_RS03590	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1S74_RS03600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1S74_RS03605	COG0702	epimerase
C1S74_RS03610	COG1823	symporter activity
C1S74_RS03620	COG2925	Exonuclease
C1S74_RS03630	COG1346	cytolysis
C1S74_RS03670	COG0072	phenylalanine-tRNA ligase activity
C1S74_RS03670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S74_RS03715	COG0251	oxidation-reduction process
C1S74_RS03740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1S74_RS03760	COG2188	Transcriptional regulator
C1S74_RS03770	COG0010	Belongs to the arginase family
C1S74_RS03780	COG2986	histidine ammonia-lyase
C1S74_RS03810	COG0277	FAD linked oxidase domain protein
C1S74_RS03810	COG0247	lactate metabolic process
C1S74_RS03910	COG1643	Atp-dependent helicase
C1S74_RS03920	COG2949	membrane
C1S74_RS03925	COG0471	metal ion transport
C1S74_RS03930	COG3706	GGDEF domain
C1S74_RS03950	COG0492	ferredoxin-NADP+ reductase activity
C1S74_RS03955	COG4988	ABC transporter
C1S74_RS03960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1S74_RS03970	COG2200	EAL domain
C1S74_RS04010	COG5001	Diguanylate cyclase
C1S74_RS04020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1S74_RS04030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S74_RS04030	COG4191	Histidine kinase
C1S74_RS04045	COG3070	regulator of competence-specific genes
C1S74_RS04060	COG2431	L-lysine efflux transmembrane transporter activity
C1S74_RS04070	COG0076	glutamate decarboxylase activity
C1S74_RS04075	COG1737	Transcriptional regulator
C1S74_RS04085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1S74_RS04095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1S74_RS04125	COG4181	ATPase activity
C1S74_RS04140	COG0534	Mate efflux family protein
C1S74_RS04145	COG0702	epimerase
C1S74_RS04150	COG1609	Transcriptional regulator
C1S74_RS04160	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S74_RS04170	COG2814	Major facilitator Superfamily
C1S74_RS04175	COG1187	pseudouridine synthase activity
C1S74_RS04180	COG1061	Type III restriction enzyme res subunit
C1S74_RS04185	COG3706	GGDEF domain
C1S74_RS04210	COG0463	Glycosyl transferase, family 2
C1S74_RS04210	COG1216	Glycosyl transferase, family 2
C1S74_RS04225	COG0454	-acetyltransferase
C1S74_RS04240	COG3313	Fe-S protein
C1S74_RS04250	COG0659	secondary active sulfate transmembrane transporter activity
C1S74_RS04280	COG0493	'glutamate synthase
C1S74_RS04290	COG0398	Pfam SNARE associated Golgi protein
C1S74_RS04295	COG4134	Bacterial extracellular solute-binding protein
C1S74_RS04300	COG4135	transport system, permease component
C1S74_RS04305	COG4136	ATPase activity
C1S74_RS04310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1S74_RS04315	COG3604	Transcriptional regulator
C1S74_RS04320	COG1151	hydroxylamine reductase activity
C1S74_RS04325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S74_RS04335	COG0564	pseudouridine synthase activity
C1S74_RS04345	COG0733	neurotransmitter:sodium symporter activity
C1S74_RS04355	COG0626	cystathionine gamma-synthase activity
C1S74_RS04360	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1S74_RS04380	COG2818	Glycosylase
C1S74_RS04390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS04410	COG1842	Phage shock protein A
C1S74_RS04415	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1S74_RS04425	COG4168	peptide transport system, permease
C1S74_RS04430	COG4171	peptide transport system, permease
C1S74_RS04440	COG4172	Belongs to the ABC transporter superfamily
C1S74_RS04450	COG1227	inorganic diphosphatase activity
C1S74_RS04465	COG0243	molybdopterin cofactor binding
C1S74_RS04470	COG3005	denitrification pathway
C1S74_RS04475	COG4459	periplasmic nitrate reductase
C1S74_RS04480	COG0390	transport system, permease component
C1S74_RS04490	COG2116	formate transmembrane transporter activity
C1S74_RS04515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S74_RS04520	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1S74_RS04525	COG1435	thymidine kinase activity
C1S74_RS04530	COG0215	cysteine-tRNA ligase activity
C1S74_RS04535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1S74_RS04540	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1S74_RS04545	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1S74_RS04550	COG3012	SEC-C Motif Domain Protein
C1S74_RS04555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1S74_RS04555	COG0140	phosphoribosyl-ATP diphosphatase activity
C1S74_RS04565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1S74_RS04570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1S74_RS04575	COG0131	Imidazoleglycerol-phosphate dehydratase
C1S74_RS04575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1S74_RS04585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1S74_RS04595	COG1757	Na H antiporter
C1S74_RS04605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S74_RS04625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1S74_RS04645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S74_RS04660	COG0300	oxidoreductase activity
C1S74_RS04710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1S74_RS04735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1S74_RS04745	COG1674	ftsk spoiiie
C1S74_RS04755	COG0686	Belongs to the AlaDH PNT family
C1S74_RS04765	COG0583	DNA-binding transcription factor activity
C1S74_RS04805	COG3181	Tripartite tricarboxylate transporter family receptor
C1S74_RS04820	COG4934	collagen metabolic process
C1S74_RS04840	COG3568	Endonuclease Exonuclease Phosphatase
C1S74_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS04870	COG1917	Cupin 2, conserved barrel domain protein
C1S74_RS04880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S74_RS04885	COG1904	glucuronate isomerase
C1S74_RS04905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1S74_RS04920	COG0800	Aldolase
C1S74_RS04925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S74_RS04930	COG1917	Cupin 2, conserved barrel domain protein
C1S74_RS04955	COG2186	Transcriptional regulator
C1S74_RS04960	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS04965	COG2186	Transcriptional regulator
C1S74_RS04970	COG0517	IMP dehydrogenase activity
C1S74_RS04975	COG2176	DNA-directed DNA polymerase activity
C1S74_RS04995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1S74_RS05010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S74_RS05045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S74_RS05050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS05080	COG0747	negative chemotaxis
C1S74_RS05085	COG4608	Belongs to the ABC transporter superfamily
C1S74_RS05090	COG0444	Belongs to the ABC transporter superfamily
C1S74_RS05095	COG0534	Mate efflux family protein
C1S74_RS05100	COG2824	Alkylphosphonate utilization operon protein PhnA
C1S74_RS05105	COG2723	6-phospho-beta-galactosidase activity
C1S74_RS05110	COG1263	PTS System
C1S74_RS05110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S74_RS05125	COG3119	arylsulfatase activity
C1S74_RS05175	COG0514	ATP-dependent DNA helicase (RecQ)
C1S74_RS05190	COG0784	Response regulator, receiver
C1S74_RS05190	COG5002	protein histidine kinase activity
C1S74_RS05210	COG0754	glutathionylspermidine amidase activity
C1S74_RS05220	COG3766	membrane
C1S74_RS05235	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1S74_RS05240	COG2885	chlorophyll binding
C1S74_RS05245	COG0823	Involved in the tonB-independent uptake of proteins
C1S74_RS05260	COG0811	peptide transport
C1S74_RS05265	COG0824	Thioesterase
C1S74_RS05275	COG4890	Cyd operon protein YbgT
C1S74_RS05280	COG1294	oxidase, subunit
C1S74_RS05285	COG1271	oxidase subunit
C1S74_RS05295	COG0632	four-way junction helicase activity
C1S74_RS05310	COG1801	Protein of unknown function DUF72
C1S74_RS05330	COG0189	ligase activity
C1S74_RS05330	COG4067	protein conserved in archaea
C1S74_RS05370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1S74_RS05375	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1S74_RS05380	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
C1S74_RS05385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S74_RS05390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1S74_RS05395	COG0745	RESPONSE REGULATOR receiver
C1S74_RS05410	COG3070	regulator of competence-specific genes
C1S74_RS05430	COG0297	glycogen (starch) synthase activity
C1S74_RS05435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1S74_RS05440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1S74_RS05470	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1S74_RS05475	COG0542	response to heat
C1S74_RS05485	COG1278	Cold shock
C1S74_RS05495	COG1187	pseudouridine synthase activity
C1S74_RS05500	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1S74_RS05510	COG1199	ATP-dependent helicase activity
C1S74_RS05515	COG0730	response to heat
C1S74_RS05520	COG3923	Primosomal replication protein n
C1S74_RS05530	COG0708	Exodeoxyribonuclease III
C1S74_RS05540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS05580	COG1882	Formate acetyltransferase
C1S74_RS05590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1S74_RS05610	COG2766	serine protein kinase
C1S74_RS05615	COG2718	Belongs to the UPF0229 family
C1S74_RS05620	COG2719	SpoVR family
C1S74_RS05645	COG1132	(ABC) transporter
C1S74_RS05650	COG2333	competence protein COMEC
C1S74_RS05650	COG0658	competence protein
C1S74_RS05660	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1S74_RS05665	COG1136	(ABC) transporter
C1S74_RS05670	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1S74_RS05680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1S74_RS05695	COG1252	NADH dehydrogenase
C1S74_RS05725	COG0537	adenosine 5'-monophosphoramidase activity
C1S74_RS05755	COG0517	IMP dehydrogenase activity
C1S74_RS05755	COG0516	GMP reductase activity
C1S74_RS05760	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C1S74_RS05765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1S74_RS05770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S74_RS05775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1S74_RS05830	COG0732	type I restriction modification DNA specificity domain
C1S74_RS05905	COG2199	diguanylate cyclase activity
C1S74_RS05920	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C1S74_RS05925	COG1946	Acyl-CoA thioesterase
C1S74_RS05930	COG1522	sequence-specific DNA binding
C1S74_RS05950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S74_RS05955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS06005	COG2855	membrane
C1S74_RS06035	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1S74_RS06040	COG0596	Alpha beta hydrolase
C1S74_RS06050	COG1169	isochorismate synthase
C1S74_RS06055	COG0436	Aminotransferase
C1S74_RS06060	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1S74_RS06080	COG1555	photosystem II stabilization
C1S74_RS06085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S74_RS06090	COG0776	regulation of translation
C1S74_RS06095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1S74_RS06130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1S74_RS06135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1S74_RS06140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1S74_RS06155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1S74_RS06160	COG0569	domain protein
C1S74_RS06165	COG0513	Belongs to the DEAD box helicase family
C1S74_RS06170	COG1253	flavin adenine dinucleotide binding
C1S74_RS06175	COG4771	TonB-dependent receptor
C1S74_RS06190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1S74_RS06190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1S74_RS06195	COG1535	isochorismatase
C1S74_RS06195	COG3433	isochorismatase activity
C1S74_RS06200	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1S74_RS06205	COG1169	isochorismate synthase
C1S74_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS06230	COG2226	methyltransferase
C1S74_RS06285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1S74_RS06290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1S74_RS06300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S74_RS06310	COG1216	Glycosyl transferase, family 2
C1S74_RS06315	COG2986	histidine ammonia-lyase
C1S74_RS06350	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS06375	COG2852	Protein conserved in bacteria
C1S74_RS06380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1S74_RS06390	COG2951	lytic endotransglycosylase activity
C1S74_RS06405	COG2894	cell division
C1S74_RS06410	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1S74_RS06415	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1S74_RS06420	COG0318	PFAM AMP-dependent synthetase and ligase
C1S74_RS06425	COG2267	carboxylic ester hydrolase activity
C1S74_RS06430	COG3065	identical protein binding
C1S74_RS06445	COG1214	PFAM Peptidase M22, glycoprotease
C1S74_RS06450	COG1199	ATP-dependent helicase activity
C1S74_RS06455	COG0788	formyltetrahydrofolate deformylase activity
C1S74_RS06460	COG3102	Protein conserved in bacteria
C1S74_RS06490	COG1918	ferrous iron import across plasma membrane
C1S74_RS06495	COG4977	sequence-specific DNA binding
C1S74_RS06500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1S74_RS06505	COG1121	(ABC) transporter
C1S74_RS06510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1S74_RS06530	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1S74_RS06535	COG0567	Dehydrogenase, E1 component
C1S74_RS06545	COG1053	succinate dehydrogenase
C1S74_RS06550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1S74_RS06565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1S74_RS06575	COG0033	Phosphoglucomutase
C1S74_RS06580	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1S74_RS06585	COG0596	Alpha beta hydrolase
C1S74_RS06595	COG0716	FMN binding
C1S74_RS06605	COG0735	belongs to the Fur family
C1S74_RS06620	COG1263	PTS System
C1S74_RS06620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S74_RS06620	COG2190	(PTS) system
C1S74_RS06630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1S74_RS06635	COG1940	carbohydrate kinase activity
C1S74_RS06635	COG1846	Transcriptional regulator
C1S74_RS06640	COG4651	solute:proton antiporter activity
C1S74_RS06640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1S74_RS06645	COG0367	asparagine synthase
C1S74_RS06650	COG0250	Participates in transcription elongation, termination and antitermination
C1S74_RS06655	COG3104	oligopeptide transport
C1S74_RS06660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1S74_RS06675	COG3710	Transcriptional regulator
C1S74_RS06695	COG0622	Phosphoesterase
C1S74_RS06725	COG1090	epimerase
C1S74_RS06730	COG0300	oxidoreductase activity
C1S74_RS06740	COG3118	belongs to the thioredoxin family
C1S74_RS06745	COG3118	belongs to the thioredoxin family
C1S74_RS06745	COG0457	Tetratricopeptide repeat
C1S74_RS06750	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C1S74_RS06755	COG1215	transferase activity, transferring glycosyl groups
C1S74_RS06760	COG1215	transferase activity, transferring glycosyl groups
C1S74_RS06780	COG2194	sulfuric ester hydrolase activity
C1S74_RS06785	COG0330	HflC and HflK could
C1S74_RS06820	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C1S74_RS06825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1S74_RS06835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S74_RS06840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1S74_RS06845	COG2190	(PTS) system
C1S74_RS06850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S74_RS06855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S74_RS06865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S74_RS06880	COG1705	Flagellar rod assembly protein muramidase FlgJ
C1S74_RS06880	COG3951	Flagellar rod assembly protein muramidase FlgJ
C1S74_RS06885	COG1706	bacterial-type flagellum-dependent cell motility
C1S74_RS06890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1S74_RS06900	COG4787	bacterial-type flagellum-dependent cell motility
C1S74_RS06905	COG1749	Flagellar hook protein flgE
C1S74_RS06915	COG1558	bacterial-type flagellum-dependent cell motility
C1S74_RS06920	COG1815	bacterial-type flagellum-dependent cell motility
C1S74_RS06925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1S74_RS06930	COG0784	Response regulator, receiver
C1S74_RS06930	COG0835	chemotaxis
C1S74_RS06985	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1S74_RS07005	COG2217	Heavy metal translocating P-type atpase
C1S74_RS07005	COG2608	mercury ion transmembrane transporter activity
C1S74_RS07045	COG2840	Smr protein MutS2
C1S74_RS07050	COG1187	pseudouridine synthase activity
C1S74_RS07055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1S74_RS07060	COG0737	Belongs to the 5'-nucleotidase family
C1S74_RS07070	COG2912	Transglutaminase-like superfamily
C1S74_RS07075	COG3094	Invasion gene expression up-regulator, SirB
C1S74_RS07080	COG2890	protein-(glutamine-N5) methyltransferase activity
C1S74_RS07105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1S74_RS07225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S74_RS07240	COG1702	phosphate starvation-inducible protein PhoH
C1S74_RS07250	COG4535	Mg2 and Co2 transporter CorC
C1S74_RS07255	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1S74_RS07260	COG2888	peptidyl-tyrosine sulfation
C1S74_RS07265	COG0495	leucyl-tRNA aminoacylation
C1S74_RS07270	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C1S74_RS07275	COG1466	dna polymerase III delta subunit
C1S74_RS07280	COG0799	negative regulation of ribosome biogenesis
C1S74_RS07285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1S74_RS07290	COG0768	penicillin binding
C1S74_RS07295	COG0772	Belongs to the SEDS family
C1S74_RS07300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1S74_RS07305	COG1686	Belongs to the peptidase S11 family
C1S74_RS07325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1S74_RS07330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C1S74_RS07335	COG0366	Alpha amylase catalytic
C1S74_RS07340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S74_RS07340	COG1263	PTS System
C1S74_RS07350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1S74_RS07355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1S74_RS07360	COG2011	ABC-type metal ion transport system permease component
C1S74_RS07365	COG1464	Belongs to the NlpA lipoprotein family
C1S74_RS07375	COG0737	Belongs to the 5'-nucleotidase family
C1S74_RS07380	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C1S74_RS07405	COG1611	Belongs to the LOG family
C1S74_RS07420	COG2363	Small membrane protein
C1S74_RS07430	COG0583	DNA-binding transcription factor activity
C1S74_RS07445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1S74_RS07455	COG0142	geranyltranstransferase activity
C1S74_RS07465	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1S74_RS07470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1S74_RS07495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S74_RS07495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S74_RS07500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1S74_RS07505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1S74_RS07520	COG1073	alpha beta
C1S74_RS07530	COG2252	PERMEase
C1S74_RS07535	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1S74_RS07560	COG0047	phosphoribosylformylglycinamidine synthase activity
C1S74_RS07560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1S74_RS07580	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1S74_RS07620	COG1301	dicarboxylic acid transport
C1S74_RS07640	COG0497	DNA recombination
C1S74_RS07650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S74_RS07655	COG2914	Belongs to the UPF0125 (RnfH) family
C1S74_RS07660	COG2867	negative regulation of translational initiation
C1S74_RS07695	COG1401	restriction endodeoxyribonuclease activity
C1S74_RS07705	COG0494	nUDIX hydrolase
C1S74_RS07710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1S74_RS07720	COG0732	type I restriction modification DNA specificity domain
C1S74_RS07725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1S74_RS07760	COG0583	DNA-binding transcription factor activity
C1S74_RS07765	COG1289	transmembrane transporter activity
C1S74_RS07785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1S74_RS07790	COG2873	o-acetylhomoserine
C1S74_RS07795	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C1S74_RS07815	COG0583	DNA-binding transcription factor activity
C1S74_RS07825	COG1115	amino acid carrier protein
C1S74_RS07830	COG1584	GPR1 FUN34 yaaH family protein
C1S74_RS07840	COG1757	Na H antiporter
C1S74_RS07850	COG0516	GMP reductase activity
C1S74_RS07850	COG0517	IMP dehydrogenase activity
C1S74_RS07865	COG2203	Gaf domain
C1S74_RS07865	COG2199	diguanylate cyclase activity
C1S74_RS07880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S74_RS07885	COG2976	Protein conserved in bacteria
C1S74_RS07920	COG2975	iron-sulfur cluster assembly
C1S74_RS07925	COG0633	Ferredoxin
C1S74_RS07940	COG0316	Belongs to the HesB IscA family
C1S74_RS07945	COG0822	iron-sulfur transferase activity
C1S74_RS07960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1S74_RS07965	COG0483	inositol monophosphate 1-phosphatase activity
C1S74_RS07975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S74_RS07980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S74_RS07985	COG1862	Preprotein translocase
C1S74_RS07990	COG0343	queuine tRNA-ribosyltransferase activity
C1S74_RS07995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1S74_RS08010	COG0517	IMP dehydrogenase activity
C1S74_RS08020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1S74_RS08025	COG0583	DNA-binding transcription factor activity
C1S74_RS08030	COG0450	alkyl hydroperoxide reductase
C1S74_RS08055	COG0704	Plays a role in the regulation of phosphate uptake
C1S74_RS08060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1S74_RS08065	COG0581	inorganic phosphate transmembrane transporter activity
C1S74_RS08070	COG0573	inorganic phosphate transmembrane transporter activity
C1S74_RS08075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1S74_RS08080	COG0248	Ppx GppA phosphatase
C1S74_RS08090	COG5002	protein histidine kinase activity
C1S74_RS08095	COG0745	RESPONSE REGULATOR receiver
C1S74_RS08105	COG0826	peptidase U32
C1S74_RS08110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1S74_RS08175	COG0542	response to heat
C1S74_RS08180	COG1496	oxidoreductase activity
C1S74_RS08185	COG0564	pseudouridine synthase activity
C1S74_RS08190	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S74_RS08195	COG0741	lytic transglycosylase activity
C1S74_RS08200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1S74_RS08205	COG1605	Chorismate mutase
C1S74_RS08205	COG0077	Prephenate dehydratase
C1S74_RS08210	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C1S74_RS08225	COG0488	(ABC) transporter
C1S74_RS08235	COG0739	heme binding
C1S74_RS08240	COG1605	Chorismate mutase
C1S74_RS08240	COG0287	Prephenate dehydrogenase
C1S74_RS08245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1S74_RS08255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1S74_RS08275	COG1966	Carbon starvation protein
C1S74_RS08280	COG3275	phosphorelay sensor kinase activity
C1S74_RS08285	COG3279	Response regulator of the LytR AlgR family
C1S74_RS08290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1S74_RS08295	COG1047	Peptidyl-prolyl cis-trans
C1S74_RS08310	COG0196	riboflavin kinase activity
C1S74_RS08315	COG0728	peptidoglycan biosynthetic process
C1S74_RS08320	COG0268	Binds directly to 16S ribosomal RNA
C1S74_RS08325	COG0640	Transcriptional regulator
C1S74_RS08330	COG0583	DNA-binding transcription factor activity
C1S74_RS08335	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1S74_RS08350	COG0730	response to heat
C1S74_RS08355	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C1S74_RS08380	COG0667	Aldo Keto reductase
C1S74_RS08405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1S74_RS08410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1S74_RS08415	COG4974	Belongs to the 'phage' integrase family
C1S74_RS08420	COG0716	FMN binding
C1S74_RS08430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1S74_RS08435	COG0513	Belongs to the DEAD box helicase family
C1S74_RS08445	COG3022	response to hydroperoxide
C1S74_RS08450	COG1115	amino acid carrier protein
C1S74_RS08490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1S74_RS08495	COG0083	homoserine kinase activity
C1S74_RS08510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1S74_RS08525	COG0745	RESPONSE REGULATOR receiver
C1S74_RS08535	COG2198	Histidine kinase
C1S74_RS08535	COG5002	protein histidine kinase activity
C1S74_RS08535	COG0784	Response regulator, receiver
C1S74_RS08540	COG5001	Diguanylate cyclase
C1S74_RS08540	COG4251	negative regulation of phosphorylation
C1S74_RS08540	COG2203	Gaf domain
C1S74_RS08540	COG3706	GGDEF domain
C1S74_RS08545	COG1242	4 iron, 4 sulfur cluster binding
C1S74_RS08550	COG0067	glutamate synthase
C1S74_RS08550	COG0070	glutamate synthase
C1S74_RS08550	COG0069	glutamate synthase activity
C1S74_RS08560	COG0069	glutamate synthase activity
C1S74_RS08560	COG0070	glutamate synthase
C1S74_RS08560	COG0067	glutamate synthase
C1S74_RS08565	COG0493	'glutamate synthase
C1S74_RS08590	COG2860	membrane
C1S74_RS08595	COG0583	DNA-binding transcription factor activity
C1S74_RS08600	COG0730	response to heat
C1S74_RS08620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1S74_RS08625	COG0505	Belongs to the CarA family
C1S74_RS08635	COG0494	nUDIX hydrolase
C1S74_RS08650	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1S74_RS08655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1S74_RS08660	COG0849	cell division
C1S74_RS08665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1S74_RS08680	COG0772	Belongs to the SEDS family
C1S74_RS08695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1S74_RS08700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1S74_RS08710	COG3116	cell division
C1S74_RS08730	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1S74_RS08745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1S74_RS08755	COG2969	positive regulation of protein catabolic process
C1S74_RS08760	COG0625	glutathione transferase activity
C1S74_RS08765	COG2857	Cytochrome c1
C1S74_RS08770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1S74_RS08775	COG0723	plastoquinol--plastocyanin reductase activity
C1S74_RS08780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1S74_RS08795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1S74_RS08815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1S74_RS08830	COG3150	esterase
C1S74_RS08840	COG3151	Protein conserved in bacteria
C1S74_RS08845	COG0494	nUDIX hydrolase
C1S74_RS08850	COG1538	Outer membrane efflux protein
C1S74_RS08860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1S74_RS08870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1S74_RS08875	COG3025	triphosphatase activity
C1S74_RS08880	COG1392	Phosphate transport regulator
C1S74_RS08885	COG0306	phosphate transporter
C1S74_RS08890	COG4991	sh3 domain protein
C1S74_RS08895	COG0405	Gamma-glutamyltransferase
C1S74_RS08905	COG3267	Type II secretory pathway component ExeA
C1S74_RS08905	COG3409	Peptidoglycan-binding domain 1 protein
C1S74_RS08920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1S74_RS08925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1S74_RS08935	COG0596	Alpha beta hydrolase
C1S74_RS08940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1S74_RS08945	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1S74_RS08950	COG1610	YqeY-like protein
C1S74_RS08955	COG0358	DNA primase activity
C1S74_RS08990	COG2213	PTS system mannitol-specific
C1S74_RS08990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S74_RS09000	COG3722	fumarate hydratase activity
C1S74_RS09010	COG5002	protein histidine kinase activity
C1S74_RS09030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1S74_RS09035	COG1349	DNA-binding transcription factor activity
C1S74_RS09040	COG0469	pyruvate kinase activity
C1S74_RS09050	COG3706	GGDEF domain
C1S74_RS09055	COG0440	acetolactate synthase activity
C1S74_RS09060	COG0028	Belongs to the TPP enzyme family
C1S74_RS09065	COG1022	Amp-dependent synthetase and ligase
C1S74_RS09070	COG0583	DNA-binding transcription factor activity
C1S74_RS09100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S74_RS09105	COG0473	3-isopropylmalate dehydrogenase activity
C1S74_RS09130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1S74_RS09135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1S74_RS09140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S74_RS09145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1S74_RS09155	COG2967	ApaG domain
C1S74_RS09170	COG3610	response to peptide
C1S74_RS09175	COG2966	Psort location CytoplasmicMembrane, score
C1S74_RS09190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1S74_RS09195	COG0142	geranyltranstransferase activity
C1S74_RS09220	COG2358	TRAP transporter, solute receptor (TAXI family
C1S74_RS09235	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1S74_RS09240	COG1178	ABC-type Fe3 transport system permease component
C1S74_RS09245	COG4143	(ABC) transporter
C1S74_RS09250	COG0163	prenyltransferase activity
C1S74_RS09255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1S74_RS09265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1S74_RS09280	COG2105	PFAM AIG2 family protein
C1S74_RS09290	COG0729	surface antigen
C1S74_RS09295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S74_RS09305	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C1S74_RS09320	COG4181	ATPase activity
C1S74_RS09340	COG0529	Catalyzes the synthesis of activated sulfate
C1S74_RS09345	COG3273	potassium ion transport
C1S74_RS09345	COG0471	metal ion transport
C1S74_RS09355	COG0175	sulfate reduction
C1S74_RS09360	COG1648	precorrin-2 dehydrogenase activity
C1S74_RS09360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1S74_RS09365	COG0737	Belongs to the 5'-nucleotidase family
C1S74_RS09375	COG0513	Belongs to the DEAD box helicase family
C1S74_RS09380	COG2153	protein acetylation
C1S74_RS09395	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S74_RS09405	COG0203	ribosomal protein L17
C1S74_RS09410	COG0202	RNA polymerase activity
C1S74_RS09420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1S74_RS09425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1S74_RS09430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1S74_RS09435	COG0201	protein transport
C1S74_RS09440	COG0200	Binds to the 23S rRNA
C1S74_RS09445	COG1841	ribosomal large subunit assembly
C1S74_RS09485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1S74_RS09515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1S74_RS09530	COG0088	Forms part of the polypeptide exit tunnel
C1S74_RS09550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1S74_RS09555	COG1609	Transcriptional regulator
C1S74_RS09580	COG1575	Belongs to the MenA family. Type 1 subfamily
C1S74_RS09585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1S74_RS09590	COG3074	FtsZ-dependent cytokinesis
C1S74_RS09600	COG1494	fructose-1,6-bisphosphatase
C1S74_RS09625	COG0149	triose-phosphate isomerase activity
C1S74_RS09630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1S74_RS09650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1S74_RS09675	COG1216	Glycosyl transferase, family 2
C1S74_RS09695	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C1S74_RS09715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1S74_RS09755	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S74_RS09765	COG1560	Kdo2-lipid A biosynthetic process
C1S74_RS09775	COG0438	transferase activity, transferring glycosyl groups
C1S74_RS09780	COG1519	Transferase
C1S74_RS09785	COG1216	Glycosyl transferase, family 2
C1S74_RS09785	COG1442	glycosyl transferase family 8
C1S74_RS09790	COG3955	Domain of unknown function (DUF1919)
C1S74_RS09800	COG3642	lipopolysaccharide core region biosynthetic process
C1S74_RS09805	COG0859	PFAM glycosyl transferase family 9
C1S74_RS09810	COG0463	Glycosyl transferase, family 2
C1S74_RS09830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1S74_RS09850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1S74_RS09860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1S74_RS09870	COG1560	Kdo2-lipid A biosynthetic process
C1S74_RS09875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1S74_RS09880	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1S74_RS09885	COG1561	YicC-like family, N-terminal region
C1S74_RS09915	COG4608	Belongs to the ABC transporter superfamily
C1S74_RS09920	COG0444	Belongs to the ABC transporter superfamily
C1S74_RS09925	COG0747	negative chemotaxis
C1S74_RS09930	COG4239	(ABC) transporter, permease
C1S74_RS09935	COG4174	ABC transporter (Permease)
C1S74_RS09960	COG0811	peptide transport
C1S74_RS09965	COG0848	biopolymer transport protein
C1S74_RS09980	COG0194	GDP metabolic process
C1S74_RS09985	COG1758	RNA polymerase activity
C1S74_RS09990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1S74_RS09995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S74_RS10000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1S74_RS10005	COG4946	Tricorn protease homolog
C1S74_RS10005	COG1506	peptidase
C1S74_RS10005	COG0823	Involved in the tonB-independent uptake of proteins
C1S74_RS10010	COG2233	PERMEase
C1S74_RS10025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S74_RS10035	COG2183	response to ionizing radiation
C1S74_RS10050	COG1040	competence protein
C1S74_RS10060	COG0494	nUDIX hydrolase
C1S74_RS10065	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1S74_RS10075	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1S74_RS10080	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1S74_RS10085	COG3156	type II secretion system protein K
C1S74_RS10090	COG4795	General secretion pathway protein
C1S74_RS10095	COG2165	general secretion pathway protein
C1S74_RS10100	COG2165	general secretion pathway protein
C1S74_RS10105	COG2165	general secretion pathway protein
C1S74_RS10110	COG1459	type II secretion system
C1S74_RS10115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1S74_RS10125	COG3031	protein transport across the cell outer membrane
C1S74_RS10130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1S74_RS10150	COG0456	acetyltransferase
C1S74_RS10155	COG1490	D-aminoacyl-tRNA deacylase activity
C1S74_RS10175	COG1217	gtp-binding protein TYPA
C1S74_RS10185	COG0174	glutamine synthetase
C1S74_RS10195	COG3852	Histidine kinase
C1S74_RS10200	COG2204	response regulator
C1S74_RS10210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1S74_RS10245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1S74_RS10255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1S74_RS10255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1S74_RS10275	COG0084	hydrolase, TatD family'
C1S74_RS10280	COG0805	protein transport
C1S74_RS10285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1S74_RS10310	COG1322	Protein conserved in bacteria
C1S74_RS10325	COG2081	HI0933 family
C1S74_RS10335	COG1528	Iron-storage protein
C1S74_RS10340	COG0589	response to stress
C1S74_RS10360	COG5002	protein histidine kinase activity
C1S74_RS10360	COG5001	Diguanylate cyclase
C1S74_RS10365	COG1522	sequence-specific DNA binding
C1S74_RS10380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1S74_RS10390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S74_RS10395	COG0800	Aldolase
C1S74_RS10400	COG2610	gluconate transmembrane transporter activity
C1S74_RS10405	COG3265	gluconokinase activity
C1S74_RS10410	COG0129	dihydroxy-acid dehydratase activity
C1S74_RS10420	COG2076	Multidrug Resistance protein
C1S74_RS10425	COG0583	DNA-binding transcription factor activity
C1S74_RS10430	COG1609	Transcriptional regulator
C1S74_RS10470	COG0601	transmembrane transport
C1S74_RS10490	COG0546	phosphoglycolate phosphatase activity
C1S74_RS10535	COG1309	transcriptional regulator
C1S74_RS10540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS10545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S74_RS10555	COG2960	long-chain fatty acid transporting porin activity
C1S74_RS10565	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1S74_RS10570	COG0583	DNA-binding transcription factor activity
C1S74_RS10615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1S74_RS10640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1S74_RS10645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1S74_RS10650	COG0551	DNA topoisomerase type I activity
C1S74_RS10660	COG0758	DNA mediated transformation
C1S74_RS10670	COG0242	peptide deformylase activity
C1S74_RS10680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1S74_RS10680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1S74_RS10685	COG0569	domain protein
C1S74_RS10690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1S74_RS10700	COG1272	protein, Hemolysin III
C1S74_RS10705	COG4326	sporulation control protein
C1S74_RS10715	COG3084	Protein conserved in bacteria
C1S74_RS10725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1S74_RS10730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1S74_RS10735	COG0204	Acyl-transferase
C1S74_RS10745	COG0606	chelatase, subunit chli
C1S74_RS10760	COG3978	acetolactate synthase activity
C1S74_RS10765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1S74_RS10780	COG3706	GGDEF domain
C1S74_RS10785	COG0583	DNA-binding transcription factor activity
C1S74_RS10790	COG2814	Major facilitator Superfamily
C1S74_RS10810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1S74_RS10820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1S74_RS10850	COG3312	ion transport
C1S74_RS10855	COG1475	DNA binding
C1S74_RS10860	COG1192	Involved in chromosome partitioning
C1S74_RS10865	COG0357	Ribosomal RNA small subunit methyltransferase G
C1S74_RS10870	COG0445	tRNA wobble uridine modification
C1S74_RS10875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1S74_RS10905	COG1126	abc transporter atp-binding protein
C1S74_RS10930	COG0592	DNA-directed DNA polymerase activity
C1S74_RS10940	COG0187	DNA topoisomerase II activity
C1S74_RS10945	COG0071	Belongs to the small heat shock protein (HSP20) family
C1S74_RS10950	COG3977	Valine--pyruvate aminotransferase
C1S74_RS10955	COG0366	Alpha amylase catalytic
C1S74_RS10970	COG2119	membrane
C1S74_RS10985	COG0425	Belongs to the sulfur carrier protein TusA family
C1S74_RS11005	COG2863	cytochrome
C1S74_RS11010	COG3258	Cytochrome c
C1S74_RS11015	COG0604	alcohol dehydrogenase
C1S74_RS11020	COG0183	Belongs to the thiolase family
C1S74_RS11030	COG1739	Uncharacterized protein family UPF0029
C1S74_RS11035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1S74_RS11075	COG2132	Multicopper oxidase
C1S74_RS11095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1S74_RS11100	COG2104	thiamine diphosphate biosynthetic process
C1S74_RS11115	COG0006	proline dipeptidase activity
C1S74_RS11115	COG0006	proline dipeptidase activity
C1S74_RS11125	COG2814	Major facilitator Superfamily
C1S74_RS11145	COG3220	belongs to the UPF0276 family
C1S74_RS11155	COG0210	DNA helicase
C1S74_RS11165	COG0405	Gamma-glutamyltransferase
C1S74_RS11170	COG1280	lysine exporter protein (LysE YggA)
C1S74_RS11180	COG2962	Rard protein
C1S74_RS11185	COG0514	ATP-dependent DNA helicase (RecQ)
C1S74_RS11200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1S74_RS11215	COG3118	belongs to the thioredoxin family
C1S74_RS11235	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1S74_RS11240	COG0633	Ferredoxin
C1S74_RS11295	COG3071	HemY protein
C1S74_RS11300	COG2959	enzyme of heme biosynthesis
C1S74_RS11305	COG1587	Uroporphyrinogen-III synthase
C1S74_RS11315	COG3072	Adenylate cyclase
C1S74_RS11325	COG1965	Belongs to the frataxin family
C1S74_RS11335	COG0019	diaminopimelate decarboxylase activity
C1S74_RS11355	COG1011	Hydrolase
C1S74_RS11360	COG2200	EAL domain
C1S74_RS11360	COG3287	FIST C domain
C1S74_RS11360	COG2199	diguanylate cyclase activity
C1S74_RS11380	COG0561	phosphatase activity
C1S74_RS11385	COG2267	carboxylic ester hydrolase activity
C1S74_RS11390	COG1280	lysine exporter protein (LysE YggA)
C1S74_RS11395	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1S74_RS11400	COG0640	Transcriptional regulator
C1S74_RS11405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1S74_RS11455	COG2095	MarC family integral membrane protein
C1S74_RS11465	COG0742	ribosomal rna small subunit methyltransferase
C1S74_RS11470	COG0552	protein localization to endoplasmic reticulum
C1S74_RS11470	COG0552	protein localization to endoplasmic reticulum
C1S74_RS11475	COG2884	Cell division ATP-binding protein ftsE
C1S74_RS11480	COG2177	Part of the ABC transporter FtsEX involved in
C1S74_RS11510	COG3161	chorismate lyase activity
C1S74_RS11520	COG2937	Belongs to the GPAT DAPAT family
C1S74_RS11540	COG0534	Mate efflux family protein
C1S74_RS11545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S74_RS11550	COG1309	transcriptional regulator
C1S74_RS11605	COG3335	DDE superfamily endonuclease
C1S74_RS11610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S74_RS11620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1S74_RS11670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1S74_RS11675	COG0250	Participates in transcription elongation, termination and antitermination
C1S74_RS11680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1S74_RS11685	COG0081	regulation of translation
C1S74_RS11690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1S74_RS11710	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C1S74_RS11715	COG2816	NAD+ diphosphatase activity
C1S74_RS11735	COG1573	uracil-dna glycosylase
C1S74_RS11745	COG3068	Protein conserved in bacteria
C1S74_RS11750	COG1253	flavin adenine dinucleotide binding
C1S74_RS11765	COG0151	Belongs to the GarS family
C1S74_RS11770	COG0138	bifunctional purine biosynthesis protein purh
C1S74_RS11775	COG0789	Transcriptional regulator
C1S74_RS11780	COG3710	Transcriptional regulator
C1S74_RS11790	COG0531	amino acid
C1S74_RS11795	COG1982	Orn Lys Arg decarboxylase major
C1S74_RS11895	COG3335	DDE superfamily endonuclease
C1S74_RS11905	COG5001	Diguanylate cyclase
C1S74_RS11905	COG3300	MHYT domain
C1S74_RS11910	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1S74_RS11915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S74_RS11930	COG0439	Biotin carboxylase
C1S74_RS11935	COG0511	ligase activity, forming carbon-carbon bonds
C1S74_RS11940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1S74_RS11945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S74_RS11960	COG2814	Major facilitator Superfamily
C1S74_RS11965	COG2205	protein histidine kinase activity
C1S74_RS11965	COG2198	Histidine kinase
C1S74_RS11965	COG0784	Response regulator, receiver
C1S74_RS11985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S74_RS11995	COG2095	MarC family integral membrane protein
C1S74_RS12005	COG4232	protein-disulfide reductase activity
C1S74_RS12010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1S74_RS12015	COG1027	Aspartate ammonia-lyase
C1S74_RS12025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1S74_RS12035	COG2205	protein histidine kinase activity
C1S74_RS12040	COG0745	RESPONSE REGULATOR receiver
C1S74_RS12045	COG3678	ATP-independent chaperone mediated protein folding
C1S74_RS12050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1S74_RS12060	COG0534	Mate efflux family protein
C1S74_RS12070	COG0459	protein refolding
C1S74_RS12080	COG1285	pathogenesis
C1S74_RS12085	COG1509	lysine 2,3-aminomutase activity
C1S74_RS12110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1S74_RS12115	COG1053	succinate dehydrogenase
C1S74_RS12140	COG4942	peptidase
C1S74_RS12145	COG1045	serine acetyltransferase
C1S74_RS12160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1S74_RS12165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1S74_RS12175	COG0840	transmembrane signaling receptor activity
C1S74_RS12180	COG0471	metal ion transport
C1S74_RS12190	COG1162	GTPase activity
C1S74_RS12270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1S74_RS12275	COG0802	atpase or kinase
C1S74_RS12280	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1S74_RS12285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1S74_RS12300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1S74_RS12305	COG0330	HflC and HflK could
C1S74_RS12310	COG0330	HflC and HflK could
C1S74_RS12315	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1S74_RS12320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1S74_RS12330	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1S74_RS12335	COG1017	nitric oxide dioxygenase activity
C1S74_RS12335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S74_RS12345	COG0557	exoribonuclease II activity
C1S74_RS12350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S74_RS12355	COG0546	phosphoglycolate phosphatase activity
C1S74_RS12375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1S74_RS12395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S74_RS12400	COG3954	Phosphoribulokinase
C1S74_RS12410	COG0429	hydrolase of the alpha beta-hydrolase fold
C1S74_RS12420	COG0488	(ABC) transporter
C1S74_RS12430	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1S74_RS12445	COG1047	Peptidyl-prolyl cis-trans
C1S74_RS12455	COG1446	asparaginase
C1S74_RS12470	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S74_RS12480	COG2964	Protein conserved in bacteria
C1S74_RS12485	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1S74_RS12490	COG2923	Belongs to the DsrF TusC family
C1S74_RS12495	COG2168	tRNA wobble position uridine thiolation
C1S74_RS12510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S74_RS12520	COG2906	2 iron, 2 sulfur cluster binding
C1S74_RS12530	COG0281	malic enzyme
C1S74_RS12540	COG0626	cystathionine gamma-synthase activity
C1S74_RS12545	COG0460	homoserine dehydrogenase
C1S74_RS12545	COG0527	aspartate kinase activity
C1S74_RS12550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1S74_RS12560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1S74_RS12570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1S74_RS12585	COG0165	Argininosuccinate lyase
C1S74_RS12585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1S74_RS12600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S74_RS12605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1S74_RS12605	COG0678	peroxiredoxin activity
C1S74_RS12615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1S74_RS12660	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C1S74_RS12665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1S74_RS12675	COG2965	DNA replication, synthesis of RNA primer
C1S74_RS12700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1S74_RS12710	COG0432	Pfam Uncharacterised protein family UPF0047
C1S74_RS12725	COG0735	belongs to the Fur family
C1S74_RS12735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S74_RS12755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1S74_RS12830	COG1410	methionine synthase
C1S74_RS12830	COG0646	methionine synthase
C1S74_RS12835	COG0527	aspartate kinase activity
C1S74_RS12845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1S74_RS12855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1S74_RS12870	COG0629	single-stranded DNA binding
C1S74_RS12875	COG2199	diguanylate cyclase activity
C1S74_RS12875	COG2200	EAL domain
C1S74_RS12900	COG3267	Type II secretory pathway component ExeA
C1S74_RS12900	COG3409	Peptidoglycan-binding domain 1 protein
C1S74_RS12910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1S74_RS12915	COG1459	type II secretion system
C1S74_RS12925	COG2165	general secretion pathway protein
C1S74_RS12960	COG1077	Cell shape determining protein MreB Mrl
C1S74_RS12965	COG1792	Involved in formation and maintenance of cell shape
C1S74_RS12970	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1S74_RS12975	COG0424	maF-like protein
C1S74_RS12985	COG3164	Protein of unknown function
C1S74_RS12990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1S74_RS12995	COG0312	modulator of DNA gyrase
C1S74_RS13000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1S74_RS13015	COG0564	pseudouridine synthase activity
C1S74_RS13020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1S74_RS13025	COG3028	Belongs to the UPF0307 family
C1S74_RS13030	COG0312	modulator of DNA gyrase
C1S74_RS13035	COG2239	Acts as a magnesium transporter
C1S74_RS13040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S74_RS13050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S74_RS13055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1S74_RS13065	COG1137	ATPase activity
C1S74_RS13070	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1S74_RS13080	COG0517	IMP dehydrogenase activity
C1S74_RS13080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1S74_RS13090	COG1127	ABC transporter
C1S74_RS13095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S74_RS13100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S74_RS13105	COG2854	intermembrane phospholipid transfer
C1S74_RS13115	COG5007	Belongs to the BolA IbaG family
C1S74_RS13125	COG0204	Acyl-transferase
C1S74_RS13130	COG0251	oxidation-reduction process
C1S74_RS13180	COG0525	valine-tRNA ligase activity
C1S74_RS13185	COG2927	DNA polymerase III (CHI subunit)
C1S74_RS13195	COG0795	lipopolysaccharide-transporting ATPase activity
C1S74_RS13200	COG0795	lipopolysaccharide-transporting ATPase activity
C1S74_RS13210	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS13220	COG0726	polysaccharide deacetylase
C1S74_RS13225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1S74_RS13235	COG1447	Phosphotransferase system cellobiose-specific component IIA
C1S74_RS13240	COG1486	melibiose metabolic process
C1S74_RS13245	COG3394	polysaccharide catabolic process
C1S74_RS13255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S74_RS13305	COG1012	belongs to the aldehyde dehydrogenase family
C1S74_RS13405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1S74_RS13410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1S74_RS13425	COG1872	DUF167
C1S74_RS13430	COG0762	integral membrane protein
C1S74_RS13435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1S74_RS13440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1S74_RS13455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1S74_RS13460	COG1678	Uncharacterized ACR, COG1678
C1S74_RS13465	COG0189	ligase activity
C1S74_RS13470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1S74_RS13475	COG2356	endonuclease I
C1S74_RS13495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1S74_RS13515	COG0191	fructose-bisphosphate aldolase activity
C1S74_RS13520	COG0668	transmembrane transport
C1S74_RS13535	COG0583	DNA-binding transcription factor activity
C1S74_RS13540	COG2968	Membrane
C1S74_RS13545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1S74_RS13555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1S74_RS13565	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C1S74_RS13570	COG3079	Belongs to the UPF0149 family
C1S74_RS13575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S74_RS13580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S74_RS13600	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1S74_RS13610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1S74_RS13620	COG1595	DNA-templated transcription, initiation
C1S74_RS13630	COG3026	antisigma factor binding
C1S74_RS13635	COG3086	response to oxidative stress
C1S74_RS13640	COG0481	GTPase activity
C1S74_RS13655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1S74_RS13660	COG1381	Involved in DNA repair and RecF pathway recombination
C1S74_RS13665	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1S74_RS13690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1S74_RS13695	COG3956	TIGRFAM MazG family protein
C1S74_RS13705	COG0148	phosphopyruvate hydratase activity
C1S74_RS13715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1S74_RS13745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1S74_RS13755	COG1546	Belongs to the CinA family
C1S74_RS13760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1S74_RS13775	COG0527	aspartate kinase activity
C1S74_RS13860	COG3630	sodium ion export across plasma membrane
C1S74_RS13865	COG5016	pyruvate
C1S74_RS13865	COG0511	ligase activity, forming carbon-carbon bonds
C1S74_RS13870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C1S74_RS13880	COG1238	metal cluster binding
C1S74_RS13885	COG0612	Peptidase, M16
C1S74_RS13905	COG4536	flavin adenine dinucleotide binding
C1S74_RS13910	COG4137	Cytochrome C assembly protein
C1S74_RS13915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1S74_RS13920	COG0228	four-way junction DNA binding
C1S74_RS13940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1S74_RS13945	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1S74_RS13950	COG0237	dephospho-CoA kinase activity
C1S74_RS13960	COG1459	type II secretion system
C1S74_RS13965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1S74_RS13985	COG2186	Transcriptional regulator
C1S74_RS13990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1S74_RS13995	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1S74_RS14000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S74_RS14015	COG0288	reversible hydration of carbon dioxide
C1S74_RS14020	COG0659	secondary active sulfate transmembrane transporter activity
C1S74_RS14025	COG1131	(ABC) transporter
C1S74_RS14030	COG0842	Transport permease protein
C1S74_RS14035	COG1560	Kdo2-lipid A biosynthetic process
C1S74_RS14050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1S74_RS14060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1S74_RS14075	COG1643	Atp-dependent helicase
C1S74_RS14080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1S74_RS14085	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1S74_RS14090	COG1049	propionate catabolic process, 2-methylcitrate cycle
C1S74_RS14105	COG0004	ammonium transporteR
C1S74_RS14110	COG1840	ABC-type Fe3 transport system, periplasmic component
C1S74_RS14120	COG3842	ATPase activity
C1S74_RS14125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1S74_RS14140	COG2971	BadF BadG BcrA BcrD
C1S74_RS14150	COG4608	Belongs to the ABC transporter superfamily
C1S74_RS14155	COG0444	Belongs to the ABC transporter superfamily
C1S74_RS14160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S74_RS14170	COG0747	negative chemotaxis
C1S74_RS14175	COG2205	protein histidine kinase activity
C1S74_RS14175	COG0784	Response regulator, receiver
C1S74_RS14190	COG0628	permease
C1S74_RS14210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S74_RS14215	COG0739	heme binding
C1S74_RS14220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1S74_RS14230	COG2027	D-alanyl-D-alanine carboxypeptidase
C1S74_RS14235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1S74_RS14240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S74_RS14245	COG1534	Rna-binding protein
C1S74_RS14250	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1S74_RS14255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1S74_RS14260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1S74_RS14270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1S74_RS14290	COG0195	Participates in both transcription termination and antitermination
C1S74_RS14310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1S74_RS14330	COG0534	Mate efflux family protein
C1S74_RS14335	COG0826	peptidase U32
C1S74_RS14340	COG0826	peptidase U32
C1S74_RS14350	COG3154	lipid carrier protein
C1S74_RS14355	COG3153	acetyltransferase
C1S74_RS14380	COG0084	hydrolase, TatD family'
C1S74_RS14385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1S74_RS14390	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1S74_RS14395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1S74_RS14405	COG0813	purine-nucleoside phosphorylase activity
C1S74_RS14415	COG0560	Phosphoserine phosphatase
C1S74_RS14425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1S74_RS14430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S74_RS14435	COG0583	DNA-binding transcription factor activity
C1S74_RS14470	COG1022	Amp-dependent synthetase and ligase
C1S74_RS14475	COG0741	lytic transglycosylase activity
C1S74_RS14500	COG4964	Belongs to the GSP D family
C1S74_RS14560	COG0583	DNA-binding transcription factor activity
C1S74_RS14565	COG0531	amino acid
C1S74_RS14570	COG2731	YhcH YjgK YiaL family protein
C1S74_RS14575	COG3250	beta-galactosidase activity
C1S74_RS14580	COG1609	Transcriptional regulator
C1S74_RS14585	COG0768	penicillin binding
C1S74_RS14595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1S74_RS14600	COG1085	galactose-1-phosphate uridylyltransferase
C1S74_RS14610	COG2017	converts alpha-aldose to the beta-anomer
C1S74_RS14615	COG1609	Transcriptional regulator
C1S74_RS14620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S74_RS14650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1S74_RS14655	COG1349	DNA-binding transcription factor activity
C1S74_RS14665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1S74_RS14675	COG2271	Major facilitator Superfamily
C1S74_RS14680	COG0584	glycerophosphoryl diester phosphodiesterase
C1S74_RS14695	COG2171	N-acyltransferase activity
C1S74_RS14710	COG3141	response to X-ray
C1S74_RS14725	COG3083	sulfuric ester hydrolase activity
C1S74_RS14730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1S74_RS14735	COG1074	ATP-dependent DNA helicase activity
C1S74_RS14740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1S74_RS14750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1S74_RS14750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1S74_RS14765	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1S74_RS14770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1S74_RS14775	COG2166	iron-sulfur cluster assembly
C1S74_RS14780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1S74_RS14785	COG0693	protein deglycase activity
C1S74_RS14790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1S74_RS14815	COG1595	DNA-templated transcription, initiation
C1S74_RS14845	COG0271	Belongs to the BolA IbaG family
C1S74_RS14850	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1S74_RS14870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1S74_RS14880	COG1477	protein flavinylation
C1S74_RS14895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1S74_RS14900	COG0514	ATP-dependent DNA helicase (RecQ)
C1S74_RS14920	COG0733	neurotransmitter:sodium symporter activity
C1S74_RS14945	COG1720	tRNA m6t6A37 methyltransferase activity
C1S74_RS14960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1S74_RS15000	COG3098	single-species biofilm formation
C1S74_RS15005	COG0564	pseudouridine synthase activity
C1S74_RS15020	COG0024	Methionine aminopeptidase
C1S74_RS15045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1S74_RS15050	COG0575	Belongs to the CDS family
C1S74_RS15060	COG0750	zinc metalloprotease
C1S74_RS15070	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C1S74_RS15075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1S74_RS15100	COG0587	DNA-directed DNA polymerase activity
C1S74_RS15120	COG0347	Belongs to the P(II) protein family
C1S74_RS15135	COG0741	lytic transglycosylase activity
C1S74_RS15135	COG1388	LysM domain
C1S74_RS15145	COG2226	methyltransferase
C1S74_RS15155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1S74_RS15195	COG1960	acyl-CoA dehydrogenase activity
C1S74_RS15200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1S74_RS15205	COG0121	glutamine amidotransferase
C1S74_RS15210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1S74_RS15220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1S74_RS15225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1S74_RS15230	COG2233	PERMEase
C1S74_RS15250	COG1393	Belongs to the ArsC family
C1S74_RS15255	COG4783	chaperone-mediated protein folding
C1S74_RS15270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1S74_RS15275	COG2716	regulation of RNA biosynthetic process
C1S74_RS15280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1S74_RS15285	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1S74_RS15300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1S74_RS15305	COG1393	Belongs to the ArsC family
C1S74_RS15330	COG2837	iron assimilation
C1S74_RS15335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S74_RS15345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S74_RS15350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S74_RS15355	COG1334	flagellar protein FlaG
C1S74_RS15360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C1S74_RS15370	COG1516	flagellar protein fliS
C1S74_RS15390	COG1677	Flagellar hook-basal body complex protein FliE
C1S74_RS15400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1S74_RS15455	COG1987	bacterial-type flagellum assembly
C1S74_RS15460	COG1684	flagellar biosynthetic protein fliR
C1S74_RS15495	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1S74_RS15500	COG2198	Histidine kinase
C1S74_RS15500	COG0784	Response regulator, receiver
C1S74_RS15500	COG0643	Histidine kinase
C1S74_RS15505	COG2201	protein-glutamate methylesterase activity
C1S74_RS15510	COG1192	Involved in chromosome partitioning
C1S74_RS15520	COG0835	chemotaxis
C1S74_RS15530	COG4133	protoheme IX ABC transporter activity
C1S74_RS15535	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1S74_RS15540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1S74_RS15555	COG1138	Cytochrome C-type biogenesis protein
C1S74_RS15560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1S74_RS15570	COG3088	subunit of a heme lyase
C1S74_RS15570	COG4235	cytochrome complex assembly
C1S74_RS15575	COG2853	Lipoprotein
C1S74_RS15580	COG2067	long-chain fatty acid transport protein
C1S74_RS15585	COG2067	long-chain fatty acid transport protein
C1S74_RS15600	COG0183	Belongs to the thiolase family
C1S74_RS15620	COG2062	phosphohistidine phosphatase, SixA
C1S74_RS15630	COG2890	protein-(glutamine-N5) methyltransferase activity
C1S74_RS15640	COG2860	membrane
C1S74_RS15645	COG3101	peptidyl-lysine hydroxylation
C1S74_RS15670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1S74_RS15680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1S74_RS15685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1S74_RS15700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1S74_RS15705	COG0285	dihydrofolate synthase activity
C1S74_RS15710	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1S74_RS15715	COG1286	toxin biosynthetic process
C1S74_RS15720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1S74_RS15725	COG0583	DNA-binding transcription factor activity
C1S74_RS15730	COG0745	RESPONSE REGULATOR receiver
C1S74_RS15740	COG2832	Protein of unknown function (DUF454)
C1S74_RS15760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1S74_RS15765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1S74_RS15770	COG0814	amino acid
C1S74_RS15775	COG0251	oxidation-reduction process
C1S74_RS15785	COG2964	Protein conserved in bacteria
C1S74_RS15800	COG2983	Belongs to the UPF0260 family
C1S74_RS15805	COG2261	transglycosylase associated protein
C1S74_RS15810	COG2985	domain, Protein
C1S74_RS15815	COG0076	glutamate decarboxylase activity
C1S74_RS15820	COG0668	transmembrane transport
C1S74_RS15830	COG0346	lactoylglutathione lyase activity
C1S74_RS15840	COG1785	Belongs to the alkaline phosphatase family
C1S74_RS15860	COG2226	methyltransferase
C1S74_RS15885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1S74_RS15890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S74_RS15900	COG3139	Protein of unknown function (DUF1315)
C1S74_RS15905	COG0252	asparaginase activity
C1S74_RS15920	COG0778	Nitroreductase
C1S74_RS15925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1S74_RS15940	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1S74_RS15945	COG4269	membrane
C1S74_RS15960	COG3083	sulfuric ester hydrolase activity
C1S74_RS15985	COG1757	Na H antiporter
C1S74_RS15990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1S74_RS16000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S74_RS16005	COG2095	MarC family integral membrane protein
C1S74_RS16010	COG1012	belongs to the aldehyde dehydrogenase family
C1S74_RS16010	COG1454	alcohol dehydrogenase
C1S74_RS16035	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1S74_RS16045	COG2056	Na+-H+ antiporter family
C1S74_RS16055	COG2885	chlorophyll binding
C1S74_RS16065	COG0346	lactoylglutathione lyase activity
C1S74_RS16070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1S74_RS16075	COG4660	Part of a membrane complex involved in electron transport
C1S74_RS16080	COG4659	FMN binding
C1S74_RS16085	COG4658	electron transport chain
C1S74_RS16090	COG4656	Part of a membrane complex involved in electron transport
C1S74_RS16100	COG4657	Part of a membrane complex involved in electron transport
C1S74_RS16105	COG1882	Formate acetyltransferase
C1S74_RS16115	COG0556	nucleotide-excision repair
C1S74_RS16130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1S74_RS16135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1S74_RS16140	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1S74_RS16145	COG0315	cyclic pyranopterin monophosphate synthase activity
C1S74_RS16150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1S74_RS16155	COG0314	molybdopterin synthase activity
C1S74_RS16165	COG0601	transmembrane transport
C1S74_RS16170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S74_RS16175	COG0444	Belongs to the ABC transporter superfamily
C1S74_RS16185	COG0435	Glutathione S-transferase
C1S74_RS16195	COG0280	phosphate acetyltransferase
C1S74_RS16195	COG0857	belongs to the CobB CobQ family
C1S74_RS16215	COG4120	Belongs to the binding-protein-dependent transport system permease family
C1S74_RS16220	COG1122	ATPase activity
C1S74_RS16225	COG0366	Alpha amylase catalytic
C1S74_RS16230	COG3706	GGDEF domain
C1S74_RS16235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S74_RS16240	COG0653	protein targeting
C1S74_RS16245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1S74_RS16255	COG2186	Transcriptional regulator
C1S74_RS16265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S74_RS16265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S74_RS16280	COG2982	Protein involved in outer membrane biogenesis
C1S74_RS16285	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C1S74_RS16290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1S74_RS16295	COG0659	secondary active sulfate transmembrane transporter activity
C1S74_RS16305	COG1530	ribonuclease E activity
C1S74_RS16310	COG0564	pseudouridine synthase activity
C1S74_RS16315	COG0424	maF-like protein
C1S74_RS16320	COG1399	metal-binding, possibly nucleic acid-binding protein
C1S74_RS16335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1S74_RS16365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1S74_RS16380	COG0084	hydrolase, TatD family'
C1S74_RS16385	COG1263	PTS System
C1S74_RS16385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S74_RS16400	COG0733	neurotransmitter:sodium symporter activity
C1S74_RS16415	COG4667	esterase of the alpha-beta hydrolase superfamily
C1S74_RS16430	COG1940	carbohydrate kinase activity
C1S74_RS16435	COG0835	chemotaxis
C1S74_RS16435	COG0784	Response regulator, receiver
C1S74_RS16455	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS16460	COG0616	signal peptide processing
C1S74_RS16475	COG0539	negative regulation of cytoplasmic translation
C1S74_RS16485	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C1S74_RS16490	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1S74_RS16495	COG0284	orotidine-5'-phosphate decarboxylase activity
C1S74_RS16500	COG4166	transmembrane transport
C1S74_RS16525	COG3119	arylsulfatase activity
C1S74_RS16530	COG1309	transcriptional regulator
C1S74_RS16535	COG3009	Protein conserved in bacteria
C1S74_RS16540	COG3008	intermembrane lipid transfer
C1S74_RS16540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S74_RS16545	COG2995	paraquat-inducible protein a
C1S74_RS16550	COG1609	Transcriptional regulator
C1S74_RS16555	COG3258	Cytochrome c
C1S74_RS16560	COG2863	cytochrome
C1S74_RS16590	COG3250	beta-galactosidase activity
C1S74_RS16600	COG4580	involved in the transport of maltose and maltodextrins
C1S74_RS16610	COG2211	Major facilitator Superfamily
C1S74_RS16625	COG4232	protein-disulfide reductase activity
C1S74_RS16630	COG3118	belongs to the thioredoxin family
C1S74_RS16640	COG4106	trans-aconitate 2-methyltransferase activity
C1S74_RS16650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S74_RS16670	COG3153	acetyltransferase
C1S74_RS16685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS16700	COG1136	(ABC) transporter
C1S74_RS16700	COG0577	efflux transmembrane transporter activity
C1S74_RS16705	COG0577	efflux transmembrane transporter activity
C1S74_RS16705	COG1136	(ABC) transporter
C1S74_RS16710	COG2176	DNA-directed DNA polymerase activity
C1S74_RS16725	COG0583	DNA-binding transcription factor activity
C1S74_RS16795	COG5002	protein histidine kinase activity
C1S74_RS16795	COG3850	Histidine kinase
C1S74_RS16800	COG0745	RESPONSE REGULATOR receiver
C1S74_RS16805	COG0463	Glycosyl transferase, family 2
C1S74_RS16810	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1S74_RS16820	COG0840	transmembrane signaling receptor activity
C1S74_RS16825	COG2964	Protein conserved in bacteria
C1S74_RS16840	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S74_RS16860	COG1032	radical SAM domain protein
C1S74_RS16865	COG5001	Diguanylate cyclase
C1S74_RS16865	COG1716	ATPase activity
C1S74_RS16870	COG5492	domain, Protein
C1S74_RS16870	COG4932	domain protein
C1S74_RS16890	COG0583	DNA-binding transcription factor activity
C1S74_RS16895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1S74_RS16905	COG2350	Protein conserved in bacteria
C1S74_RS16940	COG0159	tryptophan synthase activity
C1S74_RS16950	COG0135	phosphoribosylanthranilate isomerase activity
C1S74_RS16950	COG0134	indole-3-glycerol-phosphate synthase activity
C1S74_RS16960	COG0512	Glutamine amidotransferase of anthranilate synthase
C1S74_RS16965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1S74_RS16975	COG0613	PHP domain protein
C1S74_RS16980	COG0009	L-threonylcarbamoyladenylate synthase
C1S74_RS16990	COG1187	pseudouridine synthase activity
C1S74_RS17010	COG0417	DNA replication proofreading
C1S74_RS17015	COG2197	response regulator
C1S74_RS17020	COG0322	excinuclease ABC activity
C1S74_RS17065	COG0019	diaminopimelate decarboxylase activity
C1S74_RS17090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S74_RS17095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S74_RS17100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S74_RS17120	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1S74_RS17130	COG0437	4 iron, 4 sulfur cluster binding
C1S74_RS17135	COG3301	Polysulphide reductase, NrfD
C1S74_RS17140	COG1138	Cytochrome C-type biogenesis protein
C1S74_RS17150	COG3088	subunit of a heme lyase
C1S74_RS17150	COG4235	cytochrome complex assembly
C1S74_RS17160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S74_RS17185	COG2989	Protein conserved in bacteria
C1S74_RS17190	COG3108	Peptidase M15
C1S74_RS17195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S74_RS17225	COG0312	modulator of DNA gyrase
C1S74_RS17230	COG0312	modulator of DNA gyrase
C1S74_RS17235	COG0351	phosphomethylpyrimidine kinase
C1S74_RS17240	COG1116	anion transmembrane transporter activity
C1S74_RS17245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S74_RS17250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S74_RS17255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C1S74_RS17270	COG0671	phosphoesterase, PA-phosphatase related
C1S74_RS17275	COG0243	molybdopterin cofactor binding
C1S74_RS17280	COG3005	denitrification pathway
C1S74_RS17290	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS17310	COG0456	acetyltransferase
C1S74_RS17335	COG0697	spore germination
C1S74_RS17340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S74_RS17345	COG1929	Belongs to the glycerate kinase type-1 family
C1S74_RS17350	COG1228	amidohydrolase
C1S74_RS17445	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1S74_RS17445	COG3408	Glycogen debranching enzyme
C1S74_RS17465	COG2814	Major facilitator Superfamily
C1S74_RS17480	COG2358	TRAP transporter, solute receptor (TAXI family
C1S74_RS17485	COG3047	cAMP biosynthetic process
C1S74_RS17490	COG1357	PFAM Pentapeptide repeats (8 copies)
C1S74_RS17540	COG0583	DNA-binding transcription factor activity
C1S74_RS17555	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C1S74_RS17560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C1S74_RS17575	COG3152	Membrane
C1S74_RS17585	COG2199	diguanylate cyclase activity
C1S74_RS17595	COG0561	phosphatase activity
C1S74_RS17600	COG0564	pseudouridine synthase activity
C1S74_RS17605	COG0534	Mate efflux family protein
C1S74_RS17610	COG1609	Transcriptional regulator
C1S74_RS17615	COG3842	ATPase activity
C1S74_RS17620	COG2723	6-phospho-beta-galactosidase activity
C1S74_RS17625	COG0395	ABC-type sugar transport system, permease component
C1S74_RS17640	COG1609	Transcriptional regulator
C1S74_RS17645	COG4580	involved in the transport of maltose and maltodextrins
C1S74_RS17650	COG5001	Diguanylate cyclase
C1S74_RS17700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C1S74_RS17710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1S74_RS17715	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C1S74_RS17725	COG2259	Doxx family
C1S74_RS17760	COG0786	glutamate:sodium symporter activity
C1S74_RS17765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S74_RS17770	COG1131	(ABC) transporter
C1S74_RS17785	COG0786	glutamate:sodium symporter activity
C1S74_RS17815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1S74_RS17825	COG3279	Response regulator of the LytR AlgR family
C1S74_RS17830	COG3275	phosphorelay sensor kinase activity
C1S74_RS17860	COG0583	DNA-binding transcription factor activity
C1S74_RS17865	COG1566	PFAM secretion protein HlyD family protein
C1S74_RS17880	COG0772	Belongs to the SEDS family
C1S74_RS17905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S74_RS17905	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
C1S74_RS17915	COG0444	Belongs to the ABC transporter superfamily
C1S74_RS17920	COG4608	Belongs to the ABC transporter superfamily
C1S74_RS17945	COG1444	tRNA N-acetyltransferase activity
C1S74_RS17970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1S74_RS17975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S74_RS17975	COG1263	PTS System
C1S74_RS17980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1S74_RS17995	COG4166	transmembrane transport
C1S74_RS18135	COG2409	Drug exporters of the RND superfamily
C1S74_RS18140	COG2197	response regulator
C1S74_RS18170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S74_RS18235	COG1132	(ABC) transporter
C1S74_RS18250	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1S74_RS18255	COG1054	Belongs to the UPF0176 family
C1S74_RS18260	COG1595	DNA-templated transcription, initiation
C1S74_RS18270	COG0513	Belongs to the DEAD box helicase family
C1S74_RS18280	COG2153	protein acetylation
C1S74_RS18285	COG2258	MOSC domain
C1S74_RS18300	COG1522	sequence-specific DNA binding
C1S74_RS18315	COG1486	melibiose metabolic process
C1S74_RS18320	COG0583	DNA-binding transcription factor activity
C1S74_RS18330	COG0346	lactoylglutathione lyase activity
C1S74_RS18350	COG2186	Transcriptional regulator
C1S74_RS18370	COG0246	Mannitol dehydrogenase
C1S74_RS18375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S74_RS18380	COG1312	Catalyzes the dehydration of D-mannonate
C1S74_RS18385	COG3634	alkyl hydroperoxide reductase activity
C1S74_RS18440	COG0577	efflux transmembrane transporter activity
C1S74_RS18445	COG1136	(ABC) transporter
C1S74_RS18455	COG0583	DNA-binding transcription factor activity
C1S74_RS18495	COG0826	peptidase U32
C1S74_RS18510	COG0840	transmembrane signaling receptor activity
C1S74_RS18515	COG0612	Peptidase, M16
C1S74_RS18545	COG0739	heme binding
C1S74_RS18555	COG4604	ABC transporter, ATP-binding protein
C1S74_RS18560	COG4605	iron ion homeostasis
C1S74_RS18565	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S74_RS18570	COG4607	ABC-type enterochelin transport system periplasmic component
C1S74_RS18575	COG0583	DNA-binding transcription factor activity
C1S74_RS18580	COG4771	TonB-dependent receptor
C1S74_RS18590	COG3214	Protein conserved in bacteria
C1S74_RS18595	COG2814	Major facilitator Superfamily
C1S74_RS18605	COG1609	Transcriptional regulator
C1S74_RS18630	COG1760	l-serine dehydratase
C1S74_RS18640	COG2199	diguanylate cyclase activity
C1S74_RS18640	COG2203	Gaf domain
C1S74_RS18675	COG2356	endonuclease I
C1S74_RS18695	COG1982	Orn Lys Arg decarboxylase major
C1S74_RS18700	COG0531	amino acid
C1S74_RS18730	COG4589	Belongs to the CDS family
C1S74_RS18780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C1S74_RS18785	COG1162	GTPase activity
C1S74_RS18800	COG1999	signal sequence binding
C1S74_RS18825	COG0058	SHG alpha-glucan phosphorylase activity
C1S74_RS18830	COG1640	4-alpha-glucanotransferase
C1S74_RS18835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1S74_RS18840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1S74_RS18845	COG0366	Alpha amylase catalytic
C1S74_RS18870	COG3366	ferrous iron transmembrane transporter activity
C1S74_RS18875	COG0700	Nucleoside recognition
C1S74_RS18880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1S74_RS18885	COG3339	Conserved Protein
C1S74_RS18895	COG1301	dicarboxylic acid transport
C1S74_RS18925	COG2814	Major facilitator Superfamily
C1S74_RS18930	COG0583	DNA-binding transcription factor activity
C1S74_RS18950	COG3206	protein involved in exopolysaccharide biosynthesis
C1S74_RS18950	COG0489	protein tyrosine kinase activity
C1S74_RS18960	COG1596	polysaccharide export
C1S74_RS18970	COG2095	MarC family integral membrane protein
C1S74_RS18975	COG4667	esterase of the alpha-beta hydrolase superfamily
C1S74_RS18985	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1S74_RS18990	COG0415	Belongs to the DNA photolyase family
C1S74_RS19025	COG1686	Belongs to the peptidase S11 family
C1S74_RS19045	COG0583	DNA-binding transcription factor activity
C1S74_RS19050	COG4628	conserved protein (DUF2132)
C1S74_RS19060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S74_RS19075	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1S74_RS19080	COG0628	permease
C1S74_RS19120	COG0583	DNA-binding transcription factor activity
C1S74_RS19150	COG2814	Major facilitator Superfamily
C1S74_RS19160	COG0454	-acetyltransferase
C1S74_RS19170	COG0745	RESPONSE REGULATOR receiver
C1S74_RS19175	COG2205	protein histidine kinase activity
C1S74_RS19200	COG2207	Transcriptional regulator
C1S74_RS19225	COG0251	oxidation-reduction process
C1S74_RS19230	COG0384	phenazine biosynthesis protein PhzF
C1S74_RS19235	COG0346	lactoylglutathione lyase activity
C1S74_RS19240	COG0488	(ABC) transporter
C1S74_RS19245	COG4628	conserved protein (DUF2132)
C1S74_RS19270	COG2197	response regulator
C1S74_RS19280	COG0431	NADPH-dependent FMN reductase
C1S74_RS19285	COG0435	Glutathione S-transferase
C1S74_RS19295	COG0488	(ABC) transporter
C1S74_RS19310	COG0583	DNA-binding transcription factor activity
C1S74_RS19325	COG3226	Transcriptional regulator
C1S74_RS19360	COG3537	Alpha-1,2-mannosidase
C1S74_RS19365	COG3537	Alpha-1,2-mannosidase
C1S74_RS19375	COG3537	Alpha-1,2-mannosidase
C1S74_RS19380	COG3537	Alpha-1,2-mannosidase
C1S74_RS19385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S74_RS19400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S74_RS19400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S74_RS19405	COG0346	lactoylglutathione lyase activity
C1S74_RS19425	COG4932	domain protein
C1S74_RS19425	COG5492	domain, Protein
C1S74_RS19435	COG0753	catalase activity
C1S74_RS19445	COG1335	isochorismatase
C1S74_RS19475	COG3136	membrane protein required for alginate biosynthesis
C1S74_RS19510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1S74_RS19525	COG3448	diguanylate cyclase activity
C1S74_RS19525	COG4175	Glycine betaine
C1S74_RS19530	COG4176	ABC-type proline glycine betaine transport system permease component
C1S74_RS19540	COG1342	Belongs to the UPF0251 family
C1S74_RS19570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S74_RS19580	COG4948	Mandelate Racemase Muconate Lactonizing
C1S74_RS19620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S74_RS19640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S74_RS19660	COG0318	PFAM AMP-dependent synthetase and ligase
C1S74_RS19665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S74_RS19685	COG3706	GGDEF domain
C1S74_RS19695	COG0786	glutamate:sodium symporter activity
C1S74_RS19700	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1S74_RS19715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS19720	COG0583	DNA-binding transcription factor activity
C1S74_RS19750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1S74_RS19755	COG2197	response regulator
C1S74_RS19765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1S74_RS19765	COG0574	Belongs to the PEP-utilizing enzyme family
C1S74_RS19775	COG2807	transmembrane transport
C1S74_RS19785	COG0252	asparaginase activity
C1S74_RS19800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1S74_RS19805	COG0583	DNA-binding transcription factor activity
C1S74_RS19830	COG3122	Protein conserved in bacteria
C1S74_RS19850	COG2255	four-way junction helicase activity
C1S74_RS19860	COG3853	Toxic anion resistance protein (TelA)
C1S74_RS19870	COG1902	pentaerythritol trinitrate reductase activity
C1S74_RS19875	COG2999	glutathione oxidoreductase activity
C1S74_RS19880	COG2814	Major facilitator Superfamily
C1S74_RS19885	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS19905	COG0583	DNA-binding transcription factor activity
C1S74_RS19915	COG0583	DNA-binding transcription factor activity
C1S74_RS19925	COG3501	Rhs element vgr protein
C1S74_RS19940	COG0513	Belongs to the DEAD box helicase family
C1S74_RS19970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S74_RS19975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1S74_RS19975	COG2207	Transcriptional regulator
C1S74_RS19980	COG0583	DNA-binding transcription factor activity
C1S74_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS20005	COG3746	phosphate-selective porin O and P
C1S74_RS20030	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS20035	COG1278	Cold shock
C1S74_RS20060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1S74_RS20070	COG0625	glutathione transferase activity
C1S74_RS20075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S74_RS20080	COG1686	Belongs to the peptidase S11 family
C1S74_RS20090	COG2226	methyltransferase
C1S74_RS20105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1S74_RS20120	COG1278	Cold shock
C1S74_RS20125	COG1741	Belongs to the pirin family
C1S74_RS20130	COG4667	esterase of the alpha-beta hydrolase superfamily
C1S74_RS20140	COG1846	Transcriptional regulator
C1S74_RS20160	COG3842	ATPase activity
C1S74_RS20165	COG0395	ABC-type sugar transport system, permease component
C1S74_RS20170	COG1175	transmembrane transport
C1S74_RS20195	COG0589	response to stress
C1S74_RS20205	COG0488	(ABC) transporter
C1S74_RS20210	COG1505	serine-type exopeptidase activity
C1S74_RS20220	COG2067	long-chain fatty acid transport protein
C1S74_RS20230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S74_RS20240	COG1858	cytochrome C peroxidase
C1S74_RS20255	COG0494	nUDIX hydrolase
C1S74_RS20275	COG0604	alcohol dehydrogenase
C1S74_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS20275	COG3321	synthase
C1S74_RS20300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S74_RS20320	COG3383	formate dehydrogenase (NAD+) activity
C1S74_RS20340	COG0842	Transport permease protein
C1S74_RS20345	COG1131	(ABC) transporter
C1S74_RS20355	COG0840	transmembrane signaling receptor activity
C1S74_RS20370	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C1S74_RS20380	COG4145	pantothenate transmembrane transporter activity
C1S74_RS20385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S74_RS20390	COG0800	Aldolase
C1S74_RS20400	COG2706	6-phosphogluconolactonase activity
C1S74_RS20405	COG0251	oxidation-reduction process
C1S74_RS20415	COG1881	PFAM PEBP family protein
C1S74_RS20430	COG0798	PFAM Bile acid sodium symporter
C1S74_RS20440	COG0747	negative chemotaxis
C1S74_RS20470	COG0814	amino acid
C1S74_RS20485	COG3314	Sporulation integral membrane protein YlbJ
C1S74_RS20510	COG0739	heme binding
C1S74_RS20515	COG5001	Diguanylate cyclase
C1S74_RS20520	COG0583	DNA-binding transcription factor activity
C1S74_RS20525	COG2814	Major facilitator Superfamily
C1S74_RS20545	COG0697	spore germination
C1S74_RS20560	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1S74_RS20580	COG1280	lysine exporter protein (LysE YggA)
C1S74_RS20590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1S74_RS20600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1S74_RS20605	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1S74_RS20610	COG1845	cytochrome c oxidase, subunit III
C1S74_RS20630	COG1612	heme a metabolic process
C1S74_RS20645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1S74_RS20650	COG2814	Major facilitator Superfamily
C1S74_RS20655	COG0840	transmembrane signaling receptor activity
C1S74_RS20660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1S74_RS20690	COG2897	thiosulfate sulfurtransferase activity
C1S74_RS20745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1S74_RS20760	COG1914	H( )-stimulated, divalent metal cation uptake system
C1S74_RS20785	COG4989	oxidoreductase activity
C1S74_RS20800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1S74_RS20800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1S74_RS20815	COG5492	domain, Protein
C1S74_RS20815	COG4932	domain protein
C1S74_RS20835	COG0402	S-adenosylhomocysteine deaminase activity
C1S74_RS20845	COG3706	GGDEF domain
C1S74_RS20870	COG4176	ABC-type proline glycine betaine transport system permease component
C1S74_RS20875	COG0517	IMP dehydrogenase activity
C1S74_RS20875	COG4175	Glycine betaine
C1S74_RS20890	COG2197	response regulator
C1S74_RS20895	COG2205	protein histidine kinase activity
C1S74_RS20895	COG0784	Response regulator, receiver
C1S74_RS20905	COG0784	Response regulator, receiver
C1S74_RS20905	COG2205	protein histidine kinase activity
C1S74_RS20915	COG0583	DNA-binding transcription factor activity
C1S74_RS20980	COG1794	racemase activity, acting on amino acids and derivatives
C1S74_RS20985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1S74_RS20990	COG5001	Diguanylate cyclase
C1S74_RS21000	COG1129	ABC transporter
C1S74_RS21005	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1S74_RS21015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S74_RS21020	COG1609	Transcriptional regulator
C1S74_RS21035	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1S74_RS21050	COG4607	ABC-type enterochelin transport system periplasmic component
C1S74_RS21055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S74_RS21060	COG4605	iron ion homeostasis
C1S74_RS21065	COG4604	ABC transporter, ATP-binding protein
C1S74_RS21070	COG0789	Transcriptional regulator
C1S74_RS21100	COG1289	transmembrane transporter activity
C1S74_RS21105	COG0210	DNA helicase
C1S74_RS21115	COG1879	ABC-type sugar transport system periplasmic component
C1S74_RS21120	COG2205	protein histidine kinase activity
C1S74_RS21120	COG2198	Histidine kinase
C1S74_RS21120	COG0784	Response regulator, receiver
C1S74_RS21150	COG3119	arylsulfatase activity
C1S74_RS21155	COG3119	arylsulfatase activity
C1S74_RS21160	COG3063	Type IV pilus biogenesis stability protein PilW
C1S74_RS21165	COG0583	DNA-binding transcription factor activity
C1S74_RS21170	COG3119	arylsulfatase activity
C1S74_RS21175	COG0641	radical SAM
C1S74_RS21180	COG0714	Associated with various cellular activities
C1S74_RS21240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1S74_RS21250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1S74_RS21255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S74_RS21255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S74_RS21260	COG0583	DNA-binding transcription factor activity
C1S74_RS21265	COG1597	lipid kinase activity
C1S74_RS21270	COG3111	PFAM Bacterial OB fold (BOF) protein
C1S74_RS21290	COG0641	radical SAM
C1S74_RS21315	COG0501	Belongs to the peptidase M48B family
C1S74_RS21320	COG1704	LemA family
C1S74_RS21325	COG3069	C4-dicarboxylate transmembrane transporter activity
C1S74_RS21355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C1S74_RS21390	COG2204	response regulator
C1S74_RS21405	COG3501	Rhs element vgr protein
C1S74_RS21430	COG0515	serine threonine protein kinase
C1S74_RS21465	COG1522	sequence-specific DNA binding
C1S74_RS21540	COG4771	TonB-dependent receptor
C1S74_RS21555	COG2205	protein histidine kinase activity
C1S74_RS21555	COG0784	Response regulator, receiver
C1S74_RS21560	COG3300	MHYT domain
C1S74_RS21560	COG5001	Diguanylate cyclase
C1S74_RS21565	COG2197	response regulator
C1S74_RS21570	COG3706	GGDEF domain
C1S74_RS21580	COG2197	response regulator
C1S74_RS21590	COG0778	Nitroreductase
C1S74_RS21600	COG0835	chemotaxis
C1S74_RS21600	COG0784	Response regulator, receiver
C1S74_RS21605	COG2165	general secretion pathway protein
C1S74_RS21615	COG2962	Rard protein
C1S74_RS21630	COG0671	phosphoesterase, PA-phosphatase related
C1S74_RS21675	COG5642	Protein of unknown function (DUF2384)
C1S74_RS21685	COG2755	lipolytic protein G-D-S-L family
C1S74_RS21685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S74_RS21695	COG0463	Glycosyl transferase, family 2
C1S74_RS21695	COG1216	Glycosyl transferase, family 2
C1S74_RS21705	COG1902	pentaerythritol trinitrate reductase activity
C1S74_RS21710	COG0346	lactoylglutathione lyase activity
C1S74_RS21745	COG0515	serine threonine protein kinase
C1S74_RS21745	COG2815	serine threonine protein kinase
C1S74_RS21780	COG0631	protein serine/threonine phosphatase activity
C1S74_RS21850	COG3209	COG3209 Rhs family protein
C1S74_RS21865	COG0420	3'-5' exonuclease activity
C1S74_RS21870	COG0419	ATPase involved in DNA repair
C1S74_RS21880	COG3469	chitinase activity
C1S74_RS21915	COG3040	lipid binding
C1S74_RS21925	COG1288	antiporter activity
C1S74_RS21935	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C1S74_RS21950	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C1S74_RS21960	COG0583	DNA-binding transcription factor activity
C1S74_RS21965	COG0277	FAD linked oxidase domain protein
C1S74_RS22010	COG2199	diguanylate cyclase activity
C1S74_RS22020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S74_RS22030	COG2116	formate transmembrane transporter activity
C1S74_RS22050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1S74_RS22070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S74_RS22085	COG3118	belongs to the thioredoxin family
C1S74_RS22090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1S74_RS22120	COG1566	PFAM secretion protein HlyD family protein
C1S74_RS22130	COG0628	permease
C1S74_RS22140	COG1482	cell wall glycoprotein biosynthetic process
C1S74_RS22145	COG2271	Major facilitator Superfamily
C1S74_RS22150	COG3851	Histidine kinase
C1S74_RS22155	COG2197	response regulator
C1S74_RS22235	COG1328	CTP reductase activity
C1S74_RS22240	COG0602	queuosine metabolic process
C1S74_RS22245	COG0534	Mate efflux family protein
C1S74_RS22250	COG2207	Transcriptional regulator
C1S74_RS22270	COG3111	PFAM Bacterial OB fold (BOF) protein
C1S74_RS22280	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1S74_RS22285	COG4149	molybdate abc transporter
C1S74_RS22290	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1S74_RS22300	COG4251	negative regulation of phosphorylation
C1S74_RS22300	COG3706	GGDEF domain
C1S74_RS22300	COG5001	Diguanylate cyclase
C1S74_RS22300	COG2203	Gaf domain
C1S74_RS22330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1S74_RS22335	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1S74_RS22345	COG0745	RESPONSE REGULATOR receiver
C1S74_RS22360	COG3140	Belongs to the UPF0181 family
C1S74_RS22365	COG0023	Translation Initiation Factor
C1S74_RS22385	COG1042	CoA-binding domain protein
C1S74_RS22385	COG0045	succinate-CoA ligase (ADP-forming) activity
C1S74_RS22385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S74_RS22390	COG0583	DNA-binding transcription factor activity
C1S74_RS22405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1S74_RS22410	COG3447	MASE1 domain protein
C1S74_RS22410	COG5002	protein histidine kinase activity
C1S74_RS22410	COG5001	Diguanylate cyclase
C1S74_RS22420	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1S74_RS22425	COG1984	allophanate hydrolase subunit 2
C1S74_RS22435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1S74_RS22440	COG4181	ATPase activity
C1S74_RS22450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1S74_RS22455	COG5001	Diguanylate cyclase
C1S74_RS22455	COG3300	MHYT domain
C1S74_RS22465	COG0484	heat shock protein binding
C1S74_RS22500	COG2050	protein possibly involved in aromatic compounds catabolism
C1S74_RS22515	COG2067	long-chain fatty acid transport protein
C1S74_RS22520	COG2267	carboxylic ester hydrolase activity
C1S74_RS22525	COG2963	transposase activity
C1S74_RS22530	COG2801	Transposase and inactivated derivatives
C1S74_RS22560	COG0861	Integral membrane protein TerC family
C1S74_RS22565	COG0737	Belongs to the 5'-nucleotidase family
C1S74_RS22570	COG3593	DNA synthesis involved in DNA repair
C1S74_RS22580	COG0583	DNA-binding transcription factor activity
C1S74_RS22590	COG2116	formate transmembrane transporter activity
C1S74_RS22600	COG3038	cytochrome b561
C1S74_RS22615	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C1S74_RS22620	COG0513	Belongs to the DEAD box helicase family
C1S74_RS22625	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C1S74_RS22635	COG0840	transmembrane signaling receptor activity
C1S74_RS22645	COG0546	phosphoglycolate phosphatase activity
C1S74_RS22650	COG3437	response regulator, receiver
C1S74_RS22650	COG0784	Response regulator, receiver
C1S74_RS22665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S74_RS22675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1S74_RS22685	COG2207	Transcriptional regulator
C1S74_RS22690	COG1979	alcohol dehydrogenase
C1S74_RS22700	COG1126	abc transporter atp-binding protein
C1S74_RS22705	COG0765	amino acid transport
C1S74_RS22710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S74_RS22715	COG0765	amino acid transport
C1S74_RS22720	COG2199	diguanylate cyclase activity
C1S74_RS22720	COG2200	EAL domain
C1S74_RS22720	COG2203	Gaf domain
C1S74_RS22735	COG1609	Transcriptional regulator
C1S74_RS22740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S74_RS22740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S74_RS22745	COG1105	Belongs to the carbohydrate kinase PfkB family
C1S74_RS22750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S74_RS22750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S74_RS22750	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1S74_RS22780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS22785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS22795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1S74_RS22805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1S74_RS22810	COG0509	glycine decarboxylation via glycine cleavage system
C1S74_RS22945	COG2207	Transcriptional regulator
C1S74_RS22945	COG3708	Transcriptional regulator
C1S74_RS22965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1S74_RS22970	COG0583	DNA-binding transcription factor activity
C1S74_RS22980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S74_RS22985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S74_RS22990	COG1132	(ABC) transporter
C1S74_RS23035	COG0628	permease
C1S74_RS23055	COG0739	heme binding
C1S74_RS23065	COG1271	oxidase subunit
C1S74_RS23070	COG1294	oxidase, subunit
C1S74_RS23075	COG0745	RESPONSE REGULATOR receiver
C1S74_RS23105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S74_RS23105	COG2146	nitrite reductase [NAD(P)H] activity
C1S74_RS23110	COG1116	anion transmembrane transporter activity
C1S74_RS23115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S74_RS23120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S74_RS23120	COG1116	anion transmembrane transporter activity
C1S74_RS23145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1S74_RS23145	COG1648	precorrin-2 dehydrogenase activity
C1S74_RS23150	COG0243	molybdopterin cofactor binding
C1S74_RS23165	COG0814	amino acid
C1S74_RS23195	COG1785	Belongs to the alkaline phosphatase family
C1S74_RS23210	COG0745	RESPONSE REGULATOR receiver
C1S74_RS23240	COG2847	Copper chaperone PCu(A)C
C1S74_RS23245	COG0443	Heat shock 70 kDa protein
C1S74_RS23290	COG3119	arylsulfatase activity
C1S74_RS23310	COG4160	amino acid transport
C1S74_RS23315	COG4215	(ABC) transporter
C1S74_RS23320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S74_RS23325	COG1126	abc transporter atp-binding protein
C1S74_RS23365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S74_RS23375	COG1012	belongs to the aldehyde dehydrogenase family
C1S74_RS23390	COG1902	pentaerythritol trinitrate reductase activity
C1S74_RS23390	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S74_RS23400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1S74_RS23405	COG1845	cytochrome c oxidase, subunit III
C1S74_RS23410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1S74_RS23415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1S74_RS23420	COG1028	Short-chain dehydrogenase reductase Sdr
C1S74_RS23430	COG1024	Enoyl-CoA hydratase
C1S74_RS23435	COG1024	Enoyl-CoA hydratase
C1S74_RS23450	COG0183	Belongs to the thiolase family
C1S74_RS23460	COG1960	acyl-CoA dehydrogenase activity
C1S74_RS23465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1S74_RS23470	COG1024	Enoyl-CoA hydratase
C1S74_RS23495	COG3278	Belongs to the heme-copper respiratory oxidase family
C1S74_RS23510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1S74_RS23515	COG0513	Belongs to the DEAD box helicase family
C1S74_RS23520	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1S74_RS23535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1S74_RS23550	COG1119	ATPase activity
C1S74_RS23555	COG2200	EAL domain
C1S74_RS23575	COG0513	Belongs to the DEAD box helicase family
C1S74_RS23590	COG3447	MASE1 domain protein
C1S74_RS23590	COG5001	Diguanylate cyclase
C1S74_RS23590	COG5002	protein histidine kinase activity
C1S74_RS23595	COG0523	cobalamin synthesis protein
C1S74_RS23625	COG3530	Putative quorum-sensing-regulated virulence factor
C1S74_RS23660	COG3186	Phenylalanine-4-hydroxylase
C1S74_RS23670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S74_RS23675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S74_RS23695	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1S74_RS23700	COG1454	alcohol dehydrogenase
C1S74_RS23705	COG2133	pyrroloquinoline quinone binding
C1S74_RS23710	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1S74_RS23720	COG0783	Belongs to the Dps family
C1S74_RS23750	COG0784	Response regulator, receiver
C1S74_RS23750	COG2205	protein histidine kinase activity
C1S74_RS23755	COG1538	Outer membrane efflux protein
C1S74_RS23760	COG1132	(ABC) transporter
C1S74_RS23790	COG3036	rescue of stalled ribosome
C1S74_RS23795	COG1278	Cold shock
C1S74_RS23840	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S74_RS23845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1S74_RS23855	COG0840	transmembrane signaling receptor activity
C1S74_RS23875	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1S74_RS23890	COG2197	response regulator
C1S74_RS23895	COG3850	Histidine kinase
C1S74_RS23900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1S74_RS23920	COG3005	denitrification pathway
C1S74_RS23940	COG0183	Belongs to the thiolase family
C1S74_RS23950	COG1280	lysine exporter protein (LysE YggA)
C1S74_RS23960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S74_RS23965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S74_RS24045	COG0673	inositol 2-dehydrogenase activity
C1S74_RS24070	COG0583	DNA-binding transcription factor activity
C1S74_RS24080	COG1522	sequence-specific DNA binding
C1S74_RS24085	COG0531	amino acid
C1S74_RS24100	COG2205	protein histidine kinase activity
C1S74_RS24105	COG0745	RESPONSE REGULATOR receiver
C1S74_RS24130	COG1566	PFAM secretion protein HlyD family protein
C1S74_RS24135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1S74_RS24140	COG2239	Acts as a magnesium transporter
C1S74_RS24145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1S74_RS24150	COG0402	S-adenosylhomocysteine deaminase activity
C1S74_RS24165	COG1418	mRNA catabolic process
C1S74_RS24180	COG2814	Major facilitator Superfamily
C1S74_RS24190	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S74_RS24215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1S74_RS24230	COG4221	oxidoreductase activity
C1S74_RS24235	COG0745	RESPONSE REGULATOR receiver
C1S74_RS24240	COG2205	protein histidine kinase activity
C1S74_RS24250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1S74_RS24255	COG2194	sulfuric ester hydrolase activity
C1S74_RS24275	COG1335	isochorismatase
C1S74_RS24310	COG0583	DNA-binding transcription factor activity
C1S74_RS24315	COG0737	Belongs to the 5'-nucleotidase family
C1S74_RS24320	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1S74_RS24330	COG5492	domain, Protein
C1S74_RS24330	COG4932	domain protein
C1S74_RS24365	COG0583	DNA-binding transcription factor activity
C1S74_RS24400	COG0366	Alpha amylase catalytic
C1S74_RS24405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S74_RS24410	COG0784	Response regulator, receiver
C1S74_RS24410	COG0835	chemotaxis
C1S74_RS24425	COG0748	coenzyme F420 binding
C1S74_RS24430	COG3721	Heme iron utilization protein
C1S74_RS24440	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1S74_RS24445	COG0811	peptide transport
C1S74_RS24450	COG0848	biopolymer transport protein
C1S74_RS24460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S74_RS24465	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1S74_RS24505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1S74_RS24515	COG3217	Mosc domain protein beta barrel domain protein
C1S74_RS24515	COG0633	Ferredoxin
C1S74_RS24515	COG3217	Mosc domain protein beta barrel domain protein
C1S74_RS24515	COG0633	Ferredoxin
C1S74_RS24520	COG0401	homolog of Blt101
C1S74_RS24535	COG2354	Protein conserved in bacteria
C1S74_RS24565	COG3833	ABC-type maltose transport systems, permease component
C1S74_RS24570	COG1175	transmembrane transport
C1S74_RS24585	COG3842	ATPase activity
C1S74_RS24590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1S74_RS24650	COG1309	transcriptional regulator
C1S74_RS24655	COG2130	NADP-dependent
C1S74_RS24665	COG0753	catalase activity
C1S74_RS24670	COG2084	Dehydrogenase
C1S74_RS24680	COG0583	DNA-binding transcription factor activity
C1S74_RS24685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S74_RS24690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S74_RS24700	COG2207	Transcriptional regulator
C1S74_RS24705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S74_RS24705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S74_RS24705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S74_RS24720	COG0583	DNA-binding transcription factor activity
C1S74_RS24725	COG1566	PFAM secretion protein HlyD family protein
C1S74_RS24760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1S74_RS24820	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C1S74_RS24825	COG5001	Diguanylate cyclase
C1S74_RS24830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1S74_RS24835	COG1132	(ABC) transporter
C1S74_RS24840	COG4774	siderophore transport
C1S74_RS24845	COG1120	ATPase activity
C1S74_RS24850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1S74_RS24905	COG4191	Histidine kinase
C1S74_RS24915	COG0110	maltose O-acetyltransferase activity
C1S74_RS24950	COG0840	transmembrane signaling receptor activity
C1S74_RS24955	COG0714	Associated with various cellular activities
C1S74_RS24975	COG2304	oxidoreductase activity
C1S74_RS24990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1S74_RS24995	COG0581	inorganic phosphate transmembrane transporter activity
C1S74_RS25000	COG0573	inorganic phosphate transmembrane transporter activity
C1S74_RS25010	COG0840	transmembrane signaling receptor activity
C1S74_RS25030	COG4771	TonB-dependent receptor
C1S74_RS25035	COG1770	oligopeptidase
C1S74_RS25040	COG0513	Belongs to the DEAD box helicase family
C1S74_RS25050	COG1376	ErfK ybiS ycfS ynhG family protein
C1S74_RS25050	COG1388	LysM domain
C1S74_RS25055	COG0415	Belongs to the DNA photolyase family
C1S74_RS25060	COG0789	Transcriptional regulator
C1S74_RS25065	COG3272	Protein of unknown function (DUF1722)
C1S74_RS25075	COG0813	purine-nucleoside phosphorylase activity
C1S74_RS25105	COG1566	PFAM secretion protein HlyD family protein
C1S74_RS25115	COG1122	ATPase activity
C1S74_RS25140	COG0348	domain, Protein
C1S74_RS25145	COG0437	4 iron, 4 sulfur cluster binding
C1S74_RS25150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S74_RS25170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1S74_RS25180	COG1067	ATP-dependent peptidase activity
C1S74_RS25190	COG4172	Belongs to the ABC transporter superfamily
C1S74_RS25195	COG1505	serine-type exopeptidase activity
C1S74_RS25200	COG0583	DNA-binding transcription factor activity
C1S74_RS25205	COG1620	l-lactate permease
C1S74_RS25210	COG1304	FMN binding
C1S74_RS25220	COG0668	transmembrane transport
C1S74_RS25240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1S74_RS25250	COG2244	polysaccharide biosynthetic process
C1S74_RS25275	COG1215	transferase activity, transferring glycosyl groups
C1S74_RS25280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1S74_RS25285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1S74_RS25290	COG1063	alcohol dehydrogenase
C1S74_RS25295	COG0156	8-amino-7-oxononanoate synthase activity
C1S74_RS25320	COG0745	RESPONSE REGULATOR receiver
C1S74_RS25345	COG0346	lactoylglutathione lyase activity
C1S74_RS25395	COG0583	DNA-binding transcription factor activity
C1S74_RS25405	COG2200	EAL domain
C1S74_RS25465	COG1987	bacterial-type flagellum assembly
C1S74_RS25475	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1S74_RS25490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S74_RS25500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C1S74_RS25505	COG1516	flagellar protein fliS
C1S74_RS25520	COG1580	Controls the rotational direction of flagella during chemotaxis
C1S74_RS25525	COG1191	sigma factor activity
C1S74_RS25530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1S74_RS25535	COG1360	Flagellar Motor Protein
C1S74_RS25545	COG0384	phenazine biosynthesis protein PhzF
C1S74_RS25570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1S74_RS25600	COG2226	methyltransferase
C1S74_RS25615	COG3710	Transcriptional regulator
C1S74_RS25620	COG1253	flavin adenine dinucleotide binding
C1S74_RS25650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S74_RS25660	COG0641	radical SAM
C1S74_RS25675	COG3119	arylsulfatase activity
C1S74_RS25685	COG0583	DNA-binding transcription factor activity
C1S74_RS25695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S74_RS25700	COG1256	bacterial-type flagellum assembly
C1S74_RS25700	COG4786	Flagellar basal body rod
C1S74_RS25710	COG1706	bacterial-type flagellum-dependent cell motility
C1S74_RS25715	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1S74_RS25720	COG4786	Flagellar basal body rod
C1S74_RS25730	COG4787	bacterial-type flagellum-dependent cell motility
C1S74_RS25735	COG1749	Flagellar hook protein flgE
C1S74_RS25740	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C1S74_RS25745	COG1558	bacterial-type flagellum-dependent cell motility
C1S74_RS25750	COG1815	bacterial-type flagellum-dependent cell motility
C1S74_RS25770	COG1388	LysM domain
C1S74_RS25770	COG0741	lytic transglycosylase activity
C1S74_RS25795	COG1760	l-serine dehydratase
C1S74_RS25800	COG3104	oligopeptide transport
C1S74_RS25825	COG0583	DNA-binding transcription factor activity
C1S74_RS25840	COG2866	Carboxypeptidase
C1S74_RS25845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S74_RS25855	COG2990	Protein conserved in bacteria
C1S74_RS25880	COG3842	ATPase activity
C1S74_RS25895	COG1840	ABC-type Fe3 transport system, periplasmic component
C1S74_RS25905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1S74_RS25925	COG3240	lipase activity
C1S74_RS25965	COG1011	Hydrolase
C1S74_RS26000	COG1765	OsmC-like protein
C1S74_RS26005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S74_RS26005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S74_RS26020	COG3046	protein related to deoxyribodipyrimidine photolyase
C1S74_RS26025	COG0415	Belongs to the DNA photolyase family
C1S74_RS26030	COG3706	GGDEF domain
C1S74_RS26045	COG3706	GGDEF domain
C1S74_RS26065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1S74_RS26070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1S74_RS26105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C1S74_RS26110	COG0579	oxidoreductase
C1S74_RS26130	COG1114	Component of the transport system for branched-chain amino acids
C1S74_RS26170	COG0583	DNA-binding transcription factor activity
C1S74_RS26195	COG0189	ligase activity
C1S74_RS26200	COG4067	protein conserved in archaea
C1S74_RS26200	COG0189	ligase activity
C1S74_RS26210	COG1166	arginine decarboxylase activity
C1S74_RS26215	COG0010	Belongs to the arginase family
C1S74_RS26220	COG2814	Major facilitator Superfamily
C1S74_RS26225	COG1770	oligopeptidase
C1S74_RS26240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1S74_RS26245	COG1121	(ABC) transporter
C1S74_RS26250	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1S74_RS26295	COG0848	biopolymer transport protein
C1S74_RS26300	COG0811	peptide transport
C1S74_RS26305	COG0811	peptide transport
C1S74_RS26325	COG0745	RESPONSE REGULATOR receiver
C1S74_RS26330	COG0584	glycerophosphoryl diester phosphodiesterase
C1S74_RS26340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family