locus-tag	class	description
NP165_RS00010	COG0592	DNA-directed DNA polymerase activity
NP165_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NP165_RS00020	COG0187	DNA topoisomerase II activity
NP165_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
NP165_RS00035	COG3977	Valine--pyruvate aminotransferase
NP165_RS00040	COG0751	glycine-tRNA ligase activity
NP165_RS00050	COG2119	membrane
NP165_RS00080	COG0604	alcohol dehydrogenase
NP165_RS00090	COG0129	dihydroxy-acid dehydratase activity
NP165_RS00095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP165_RS00100	COG3978	acetolactate synthase activity
NP165_RS00110	COG0606	chelatase, subunit chli
NP165_RS00125	COG1473	amidohydrolase
NP165_RS00145	COG0204	Acyl-transferase
NP165_RS00150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP165_RS00155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP165_RS00165	COG3084	Protein conserved in bacteria
NP165_RS00175	COG4326	sporulation control protein
NP165_RS00180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP165_RS00185	COG0569	domain protein
NP165_RS00190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP165_RS00190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP165_RS00195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NP165_RS00210	COG0758	DNA mediated transformation
NP165_RS00215	COG2922	Belongs to the Smg family
NP165_RS00220	COG0551	DNA topoisomerase type I activity
NP165_RS00225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NP165_RS00230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NP165_RS00240	COG0408	coproporphyrinogen oxidase activity
NP165_RS00245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP165_RS00255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NP165_RS00305	COG0601	transmembrane transport
NP165_RS00310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP165_RS00330	COG0515	serine threonine protein kinase
NP165_RS00330	COG2815	serine threonine protein kinase
NP165_RS00335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP165_RS00340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NP165_RS00360	COG3220	belongs to the UPF0276 family
NP165_RS00370	COG0210	DNA helicase
NP165_RS00380	COG0405	Gamma-glutamyltransferase
NP165_RS00385	COG1280	lysine exporter protein (LysE YggA)
NP165_RS00390	COG2207	Transcriptional regulator
NP165_RS00395	COG2962	Rard protein
NP165_RS00400	COG0514	ATP-dependent DNA helicase (RecQ)
NP165_RS00410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NP165_RS00415	COG0248	Ppx GppA phosphatase
NP165_RS00425	COG3118	belongs to the thioredoxin family
NP165_RS00440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NP165_RS00475	COG3335	DDE superfamily endonuclease
NP165_RS00485	COG3071	HemY protein
NP165_RS00490	COG2959	enzyme of heme biosynthesis
NP165_RS00495	COG1587	Uroporphyrinogen-III synthase
NP165_RS00505	COG3072	Adenylate cyclase
NP165_RS00520	COG0019	diaminopimelate decarboxylase activity
NP165_RS00525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NP165_RS00535	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NP165_RS00540	COG1011	Hydrolase
NP165_RS00550	COG3148	PFAM DTW domain containing protein
NP165_RS00565	COG0561	phosphatase activity
NP165_RS00575	COG1280	lysine exporter protein (LysE YggA)
NP165_RS00580	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP165_RS00585	COG0640	Transcriptional regulator
NP165_RS00590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP165_RS00630	COG2095	MarC family integral membrane protein
NP165_RS00640	COG0742	ribosomal rna small subunit methyltransferase
NP165_RS00645	COG0552	protein localization to endoplasmic reticulum
NP165_RS00650	COG2884	Cell division ATP-binding protein ftsE
NP165_RS00655	COG2177	Part of the ABC transporter FtsEX involved in
NP165_RS00670	COG0705	Rhomboid family
NP165_RS00675	COG1580	Controls the rotational direction of flagella during chemotaxis
NP165_RS00680	COG3161	chorismate lyase activity
NP165_RS00685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NP165_RS00690	COG2937	Belongs to the GPAT DAPAT family
NP165_RS00695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP165_RS00700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NP165_RS00710	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NP165_RS00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP165_RS00745	COG4206	TonB-dependent receptor
NP165_RS00755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP165_RS00845	COG3335	DDE superfamily endonuclease
NP165_RS00855	COG3335	DDE superfamily endonuclease
NP165_RS00870	COG3335	DDE superfamily endonuclease
NP165_RS00885	COG1494	fructose-1,6-bisphosphatase
NP165_RS00890	COG3074	FtsZ-dependent cytokinesis
NP165_RS00895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NP165_RS00900	COG0527	aspartate kinase activity
NP165_RS00900	COG0460	homoserine dehydrogenase
NP165_RS00905	COG0626	cystathionine gamma-synthase activity
NP165_RS00910	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
NP165_RS00915	COG0281	malic enzyme
NP165_RS00920	COG0254	rRNA binding
NP165_RS00925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP165_RS00930	COG1609	Transcriptional regulator
NP165_RS00935	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP165_RS00940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NP165_RS00965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NP165_RS00970	COG1053	succinate dehydrogenase
NP165_RS00975	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NP165_RS00980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP165_RS00995	COG1045	serine acetyltransferase
NP165_RS01005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NP165_RS01010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP165_RS01015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NP165_RS01025	COG0137	argininosuccinate synthase activity
NP165_RS01030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NP165_RS01030	COG0165	Argininosuccinate lyase
NP165_RS01040	COG0251	oxidation-reduction process
NP165_RS01045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP165_RS01050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NP165_RS01050	COG0678	peroxiredoxin activity
NP165_RS01060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NP165_RS01105	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NP165_RS01110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP165_RS01115	COG0546	phosphoglycolate phosphatase activity
NP165_RS01120	COG0180	Tryptophanyl-tRNA synthetase
NP165_RS01125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NP165_RS01135	COG2205	protein histidine kinase activity
NP165_RS01140	COG0745	RESPONSE REGULATOR receiver
NP165_RS01150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP165_RS01155	COG0205	6-phosphofructokinase activity
NP165_RS01160	COG1285	pathogenesis
NP165_RS01165	COG1509	lysine 2,3-aminomutase activity
NP165_RS01175	COG1575	Belongs to the MenA family. Type 1 subfamily
NP165_RS01180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NP165_RS01185	COG0534	Mate efflux family protein
NP165_RS01190	COG0149	triose-phosphate isomerase activity
NP165_RS01205	COG1072	(Pantothenic acid kinase))
NP165_RS01235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP165_RS01240	COG0250	Participates in transcription elongation, termination and antitermination
NP165_RS01255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NP165_RS01265	COG0085	RNA polymerase activity
NP165_RS01270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NP165_RS01275	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NP165_RS01300	COG4942	peptidase
NP165_RS01305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NP165_RS01320	COG0471	metal ion transport
NP165_RS01320	COG0490	domain, Protein
NP165_RS01330	COG1162	GTPase activity
NP165_RS01335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NP165_RS01415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NP165_RS01420	COG0802	atpase or kinase
NP165_RS01425	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP165_RS01430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NP165_RS01445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NP165_RS01450	COG0330	HflC and HflK could
NP165_RS01455	COG0330	HflC and HflK could
NP165_RS01460	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NP165_RS01465	COG2900	Belongs to the SlyX family
NP165_RS01475	COG0545	Peptidyl-prolyl cis-trans isomerase
NP165_RS01480	COG2964	Protein conserved in bacteria
NP165_RS01485	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NP165_RS01490	COG2923	Belongs to the DsrF TusC family
NP165_RS01505	COG0049	tRNA binding
NP165_RS01510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP165_RS01530	COG0360	Binds together with S18 to 16S ribosomal RNA
NP165_RS01535	COG2965	DNA replication, synthesis of RNA primer
NP165_RS01555	COG0305	Participates in initiation and elongation during chromosome replication
NP165_RS01560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP165_RS01565	COG0432	Pfam Uncharacterised protein family UPF0047
NP165_RS01570	COG0166	Belongs to the GPI family
NP165_RS01585	COG0577	efflux transmembrane transporter activity
NP165_RS01605	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NP165_RS01615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP165_RS01620	COG0729	surface antigen
NP165_RS01630	COG2105	PFAM AIG2 family protein
NP165_RS01635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NP165_RS01640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NP165_RS01645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP165_RS01650	COG0163	prenyltransferase activity
NP165_RS01655	COG4143	(ABC) transporter
NP165_RS01660	COG1178	ABC-type Fe3 transport system permease component
NP165_RS01665	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NP165_RS01670	COG3028	Belongs to the UPF0307 family
NP165_RS01675	COG0312	modulator of DNA gyrase
NP165_RS01680	COG0527	aspartate kinase activity
NP165_RS01685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP165_RS01695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP165_RS01710	COG0629	single-stranded DNA binding
NP165_RS01715	COG2199	diguanylate cyclase activity
NP165_RS01715	COG2200	EAL domain
NP165_RS01740	COG3409	Peptidoglycan-binding domain 1 protein
NP165_RS01740	COG3267	Type II secretory pathway component ExeA
NP165_RS01750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP165_RS01755	COG1459	type II secretion system
NP165_RS01760	COG2165	general secretion pathway protein
NP165_RS01765	COG2165	general secretion pathway protein
NP165_RS01795	COG1077	Cell shape determining protein MreB Mrl
NP165_RS01800	COG1792	Involved in formation and maintenance of cell shape
NP165_RS01805	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NP165_RS01810	COG0424	maF-like protein
NP165_RS01820	COG3164	Protein of unknown function
NP165_RS01825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP165_RS01830	COG0312	modulator of DNA gyrase
NP165_RS01835	COG2235	arginine
NP165_RS01855	COG0589	response to stress
NP165_RS01870	COG1438	arginine binding
NP165_RS01880	COG0251	oxidation-reduction process
NP165_RS01885	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NP165_RS01900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NP165_RS01905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP165_RS01910	COG0564	pseudouridine synthase activity
NP165_RS01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP165_RS01920	COG4269	membrane
NP165_RS01930	COG0525	valine-tRNA ligase activity
NP165_RS01935	COG2927	DNA polymerase III (CHI subunit)
NP165_RS01940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP165_RS01945	COG0795	lipopolysaccharide-transporting ATPase activity
NP165_RS01950	COG0795	lipopolysaccharide-transporting ATPase activity
NP165_RS01955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NP165_RS01960	COG3706	GGDEF domain
NP165_RS01965	COG1546	Belongs to the CinA family
NP165_RS01970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NP165_RS01975	COG2137	regulation of response to DNA damage stimulus
NP165_RS01980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP165_RS01985	COG0527	aspartate kinase activity
NP165_RS02035	COG3630	sodium ion export across plasma membrane
NP165_RS02040	COG0511	ligase activity, forming carbon-carbon bonds
NP165_RS02040	COG5016	pyruvate
NP165_RS02045	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NP165_RS02050	COG2130	NADP-dependent
NP165_RS02055	COG1238	metal cluster binding
NP165_RS02060	COG0612	Peptidase, M16
NP165_RS02065	COG2918	glutathione biosynthetic process
NP165_RS02075	COG1854	S-ribosylhomocysteine lyase activity
NP165_RS02095	COG2261	transglycosylase associated protein
NP165_RS02135	COG3437	response regulator, receiver
NP165_RS02180	COG0066	3-isopropylmalate dehydratase activity
NP165_RS02190	COG0473	3-isopropylmalate dehydrogenase activity
NP165_RS02195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP165_RS02245	COG0583	DNA-binding transcription factor activity
NP165_RS02250	COG1022	Amp-dependent synthetase and ligase
NP165_RS02255	COG0028	Belongs to the TPP enzyme family
NP165_RS02260	COG0440	acetolactate synthase activity
NP165_RS02265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP165_RS02270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NP165_RS02275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NP165_RS02290	COG3079	Belongs to the UPF0149 family
NP165_RS02295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP165_RS02300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP165_RS02320	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NP165_RS02325	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NP165_RS02330	COG1595	DNA-templated transcription, initiation
NP165_RS02345	COG3086	response to oxidative stress
NP165_RS02365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP165_RS02370	COG1381	Involved in DNA repair and RecF pathway recombination
NP165_RS02375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NP165_RS02380	COG0736	holo-[acyl-carrier-protein] synthase activity
NP165_RS02385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NP165_RS02390	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NP165_RS02395	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NP165_RS02400	COG2205	protein histidine kinase activity
NP165_RS02410	COG4999	Histidine kinase
NP165_RS02410	COG2205	protein histidine kinase activity
NP165_RS02410	COG3850	Histidine kinase
NP165_RS02410	COG3437	response regulator, receiver
NP165_RS02415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP165_RS02420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP165_RS02425	COG3956	TIGRFAM MazG family protein
NP165_RS02430	COG0504	CTP synthase activity
NP165_RS02435	COG0148	phosphopyruvate hydratase activity
NP165_RS02445	COG3267	Type II secretory pathway component ExeA
NP165_RS02445	COG3409	Peptidoglycan-binding domain 1 protein
NP165_RS02455	COG4991	sh3 domain protein
NP165_RS02460	COG0306	phosphate transporter
NP165_RS02465	COG1392	Phosphate transport regulator
NP165_RS02470	COG3025	triphosphatase activity
NP165_RS02475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NP165_RS02485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NP165_RS02490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NP165_RS02490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NP165_RS02495	COG0745	RESPONSE REGULATOR receiver
NP165_RS02505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NP165_RS02520	COG0083	homoserine kinase activity
NP165_RS02525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NP165_RS02530	COG2860	membrane
NP165_RS02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP165_RS02545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NP165_RS02550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NP165_RS02565	COG0534	Mate efflux family protein
NP165_RS02570	COG0826	peptidase U32
NP165_RS02575	COG0826	peptidase U32
NP165_RS02585	COG3154	lipid carrier protein
NP165_RS02590	COG3153	acetyltransferase
NP165_RS02595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP165_RS02610	COG0779	Required for maturation of 30S ribosomal subunits
NP165_RS02615	COG0195	Participates in both transcription termination and antitermination
NP165_RS02620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NP165_RS02625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NP165_RS02630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NP165_RS02640	COG0493	'glutamate synthase
NP165_RS02645	COG0067	glutamate synthase
NP165_RS02645	COG0069	glutamate synthase activity
NP165_RS02645	COG0070	glutamate synthase
NP165_RS02655	COG0067	glutamate synthase
NP165_RS02655	COG0069	glutamate synthase activity
NP165_RS02655	COG0070	glutamate synthase
NP165_RS02660	COG1242	4 iron, 4 sulfur cluster binding
NP165_RS02665	COG2198	Histidine kinase
NP165_RS02665	COG5002	protein histidine kinase activity
NP165_RS02665	COG0784	Response regulator, receiver
NP165_RS02675	COG1538	Outer membrane efflux protein
NP165_RS02680	COG0494	nUDIX hydrolase
NP165_RS02685	COG3151	Protein conserved in bacteria
NP165_RS02695	COG3150	esterase
NP165_RS02710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP165_RS02715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP165_RS02725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NP165_RS02740	COG0723	plastoquinol--plastocyanin reductase activity
NP165_RS02745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP165_RS02750	COG2857	Cytochrome c1
NP165_RS02755	COG0625	glutathione transferase activity
NP165_RS02760	COG2969	positive regulation of protein catabolic process
NP165_RS02765	COG2823	Periplasmic or secreted lipoprotein
NP165_RS02770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NP165_RS02775	COG0792	nuclease activity
NP165_RS02780	COG3107	peptidoglycan biosynthetic process
NP165_RS02785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NP165_RS02795	COG0275	rRNA processing
NP165_RS02800	COG3116	cell division
NP165_RS02805	COG0768	penicillin binding
NP165_RS02810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NP165_RS02815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NP165_RS02825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP165_RS02830	COG0772	Belongs to the SEDS family
NP165_RS02835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP165_RS02840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP165_RS02845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NP165_RS02850	COG0849	cell division
NP165_RS02855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NP165_RS02875	COG0494	nUDIX hydrolase
NP165_RS02885	COG0505	Belongs to the CarA family
NP165_RS02890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP165_RS02895	COG0730	response to heat
NP165_RS02900	COG0583	DNA-binding transcription factor activity
NP165_RS02905	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
NP165_RS02915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NP165_RS02930	COG1115	amino acid carrier protein
NP165_RS02935	COG3022	response to hydroperoxide
NP165_RS02945	COG0084	hydrolase, TatD family'
NP165_RS02950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP165_RS02965	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NP165_RS02980	COG0560	Phosphoserine phosphatase
NP165_RS02990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NP165_RS02995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP165_RS03000	COG0693	protein deglycase activity
NP165_RS03005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP165_RS03015	COG2211	Major facilitator Superfamily
NP165_RS03020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP165_RS03030	COG2813	Specifically methylates the guanine in position
NP165_RS03035	COG0271	Belongs to the BolA IbaG family
NP165_RS03040	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NP165_RS03045	COG1805	sodium ion transport
NP165_RS03050	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NP165_RS03055	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NP165_RS03060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NP165_RS03070	COG1477	protein flavinylation
NP165_RS03075	COG2991	Protein conserved in bacteria
NP165_RS03085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP165_RS03090	COG0514	ATP-dependent DNA helicase (RecQ)
NP165_RS03095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP165_RS03105	COG0733	neurotransmitter:sodium symporter activity
NP165_RS03115	COG0189	ligase activity
NP165_RS03120	COG4067	protein conserved in archaea
NP165_RS03120	COG0189	ligase activity
NP165_RS03125	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP165_RS03130	COG2252	PERMEase
NP165_RS03135	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NP165_RS03140	COG1073	alpha beta
NP165_RS03150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP165_RS03155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP165_RS03160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NP165_RS03165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP165_RS03165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP165_RS03185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP165_RS03190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NP165_RS03195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP165_RS03205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NP165_RS03210	COG0024	Methionine aminopeptidase
NP165_RS03225	COG0528	UMP kinase activity
NP165_RS03230	COG0233	cytoplasmic translational termination
NP165_RS03235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP165_RS03240	COG0575	Belongs to the CDS family
NP165_RS03245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NP165_RS03250	COG0750	zinc metalloprotease
NP165_RS03260	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
NP165_RS03265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NP165_RS03275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NP165_RS03280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NP165_RS03290	COG0587	DNA-directed DNA polymerase activity
NP165_RS03295	COG0825	malonyl-CoA metabolic process
NP165_RS03300	COG1464	Belongs to the NlpA lipoprotein family
NP165_RS03305	COG2011	ABC-type metal ion transport system permease component
NP165_RS03315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NP165_RS03345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP165_RS03350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP165_RS03360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP165_RS03370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NP165_RS03380	COG2921	Belongs to the UPF0250 family
NP165_RS03385	COG1686	Belongs to the peptidase S11 family
NP165_RS03390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP165_RS03395	COG0772	Belongs to the SEDS family
NP165_RS03400	COG0768	penicillin binding
NP165_RS03405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NP165_RS03410	COG0799	negative regulation of ribosome biogenesis
NP165_RS03415	COG1466	dna polymerase III delta subunit
NP165_RS03420	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NP165_RS03430	COG2888	peptidyl-tyrosine sulfation
NP165_RS03435	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NP165_RS03440	COG4535	Mg2 and Co2 transporter CorC
NP165_RS03445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NP165_RS03450	COG1702	phosphate starvation-inducible protein PhoH
NP165_RS03455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP165_RS03460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP165_RS03465	COG2190	(PTS) system
NP165_RS03470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP165_RS03475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP165_RS03480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP165_RS03485	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
NP165_RS03490	COG3115	cell septum assembly
NP165_RS03505	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NP165_RS03515	COG1585	Membrane protein implicated in regulation of membrane protease activity
NP165_RS03520	COG0330	HflC and HflK could
NP165_RS03525	COG3118	belongs to the thioredoxin family
NP165_RS03530	COG0300	oxidoreductase activity
NP165_RS03535	COG1090	epimerase
NP165_RS03560	COG0622	Phosphoesterase
NP165_RS03580	COG3710	Transcriptional regulator
NP165_RS03585	COG0326	Molecular chaperone. Has ATPase activity
NP165_RS03595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NP165_RS03605	COG2608	mercury ion transmembrane transporter activity
NP165_RS03605	COG2217	Heavy metal translocating P-type atpase
NP165_RS03660	COG0835	chemotaxis
NP165_RS03660	COG0784	Response regulator, receiver
NP165_RS03665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NP165_RS03670	COG1815	bacterial-type flagellum-dependent cell motility
NP165_RS03690	COG4787	bacterial-type flagellum-dependent cell motility
NP165_RS03700	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NP165_RS03705	COG1706	bacterial-type flagellum-dependent cell motility
NP165_RS03710	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP165_RS03710	COG3951	Flagellar rod assembly protein muramidase FlgJ
NP165_RS03720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP165_RS03730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP165_RS03850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP165_RS03855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NP165_RS03865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NP165_RS03870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP165_RS03875	COG2890	protein-(glutamine-N5) methyltransferase activity
NP165_RS03885	COG2912	Transglutaminase-like superfamily
NP165_RS03890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NP165_RS03905	COG2233	PERMEase
NP165_RS03925	COG1393	Belongs to the ArsC family
NP165_RS03930	COG4783	chaperone-mediated protein folding
NP165_RS03945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NP165_RS03950	COG2716	regulation of RNA biosynthetic process
NP165_RS03960	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NP165_RS03965	COG2056	Na+-H+ antiporter family
NP165_RS03970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NP165_RS03985	COG0346	lactoylglutathione lyase activity
NP165_RS03990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NP165_RS03995	COG4660	Part of a membrane complex involved in electron transport
NP165_RS04000	COG4659	FMN binding
NP165_RS04005	COG4658	electron transport chain
NP165_RS04010	COG4656	Part of a membrane complex involved in electron transport
NP165_RS04020	COG4657	Part of a membrane complex involved in electron transport
NP165_RS04030	COG0556	nucleotide-excision repair
NP165_RS04035	COG2204	response regulator
NP165_RS04040	COG2198	Histidine kinase
NP165_RS04045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NP165_RS04050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NP165_RS04055	COG0521	Mo-molybdopterin cofactor biosynthetic process
NP165_RS04060	COG0315	cyclic pyranopterin monophosphate synthase activity
NP165_RS04065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NP165_RS04070	COG0314	molybdopterin synthase activity
NP165_RS04075	COG4109	DRTGG domain
NP165_RS04095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP165_RS04095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP165_RS04100	COG0489	protein tyrosine kinase activity
NP165_RS04105	COG0572	uridine kinase
NP165_RS04110	COG2982	Protein involved in outer membrane biogenesis
NP165_RS04115	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NP165_RS04120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP165_RS04140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NP165_RS04145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP165_RS04155	COG0123	including yeast histone deacetylase and acetoin utilization protein
NP165_RS04165	COG1473	amidohydrolase
NP165_RS04185	COG3082	Protein of unknown function (DUF1414)
NP165_RS04195	COG1757	Na H antiporter
NP165_RS04200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP165_RS04205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP165_RS04210	COG2095	MarC family integral membrane protein
NP165_RS04215	COG1012	belongs to the aldehyde dehydrogenase family
NP165_RS04215	COG1454	alcohol dehydrogenase
NP165_RS04220	COG5507	3-demethylubiquinone-9 3-methyltransferase
NP165_RS04225	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NP165_RS04230	COG2894	cell division
NP165_RS04240	COG3100	YcgL domain-containing protein
NP165_RS04245	COG2951	lytic endotransglycosylase activity
NP165_RS04250	COG0583	DNA-binding transcription factor activity
NP165_RS04255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP165_RS04260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NP165_RS04295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP165_RS04300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP165_RS04305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NP165_RS04320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP165_RS04330	COG3721	Heme iron utilization protein
NP165_RS04335	COG0748	coenzyme F420 binding
NP165_RS04340	COG1629	transport
NP165_RS04340	COG4771	TonB-dependent receptor
NP165_RS04345	COG2204	response regulator
NP165_RS04350	COG4191	Histidine kinase
NP165_RS04355	COG0544	peptidyl-prolyl cis-trans isomerase activity
NP165_RS04370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NP165_RS04375	COG0776	regulation of translation
NP165_RS04380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP165_RS04385	COG1555	photosystem II stabilization
NP165_RS04395	COG0539	negative regulation of cytoplasmic translation
NP165_RS04405	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
NP165_RS04410	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NP165_RS04420	COG4174	ABC transporter (Permease)
NP165_RS04425	COG4239	(ABC) transporter, permease
NP165_RS04430	COG0747	negative chemotaxis
NP165_RS04435	COG0444	Belongs to the ABC transporter superfamily
NP165_RS04440	COG4608	Belongs to the ABC transporter superfamily
NP165_RS04465	COG0583	DNA-binding transcription factor activity
NP165_RS04480	COG4120	Belongs to the binding-protein-dependent transport system permease family
NP165_RS04490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP165_RS04495	COG0653	protein targeting
NP165_RS04505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NP165_RS04515	COG0252	asparaginase activity
NP165_RS04520	COG0616	signal peptide processing
NP165_RS04525	COG0446	pyridine nucleotide-disulphide oxidoreductase
NP165_RS04525	COG1902	pentaerythritol trinitrate reductase activity
NP165_RS04530	COG0788	formyltetrahydrofolate deformylase activity
NP165_RS04535	COG1199	ATP-dependent helicase activity
NP165_RS04540	COG1214	PFAM Peptidase M22, glycoprotease
NP165_RS04555	COG2267	carboxylic ester hydrolase activity
NP165_RS04560	COG0318	PFAM AMP-dependent synthetase and ligase
NP165_RS04565	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NP165_RS04570	COG0659	secondary active sulfate transmembrane transporter activity
NP165_RS04575	COG1530	ribonuclease E activity
NP165_RS04580	COG0564	pseudouridine synthase activity
NP165_RS04585	COG0424	maF-like protein
NP165_RS04590	COG1399	metal-binding, possibly nucleic acid-binding protein
NP165_RS04605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP165_RS04630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP165_RS04635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP165_RS04640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP165_RS04650	COG0084	hydrolase, TatD family'
NP165_RS04655	COG1263	PTS System
NP165_RS04655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP165_RS04670	COG4667	esterase of the alpha-beta hydrolase superfamily
NP165_RS04675	COG0469	pyruvate kinase activity
NP165_RS04680	COG1940	carbohydrate kinase activity
NP165_RS04685	COG0784	Response regulator, receiver
NP165_RS04685	COG0835	chemotaxis
NP165_RS04690	COG0583	DNA-binding transcription factor activity
NP165_RS04695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NP165_RS04700	COG0587	DNA-directed DNA polymerase activity
NP165_RS04705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP165_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
NP165_RS04720	COG0616	signal peptide processing
NP165_RS04725	COG0513	Belongs to the DEAD box helicase family
NP165_RS04745	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NP165_RS04750	COG0436	Aminotransferase
NP165_RS04755	COG1169	isochorismate synthase
NP165_RS04760	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NP165_RS04765	COG0596	Alpha beta hydrolase
NP165_RS04790	COG2855	membrane
NP165_RS04795	COG0477	Major facilitator Superfamily
NP165_RS04815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP165_RS04820	COG1522	sequence-specific DNA binding
NP165_RS04825	COG1946	Acyl-CoA thioesterase
NP165_RS04830	COG3126	Type III secretion system lipoprotein chaperone (YscW)
NP165_RS04855	COG1073	alpha beta
NP165_RS04870	COG1902	pentaerythritol trinitrate reductase activity
NP165_RS04880	COG1073	alpha beta
NP165_RS04885	COG1073	alpha beta
NP165_RS04895	COG2207	Transcriptional regulator
NP165_RS04905	COG2423	ornithine cyclodeaminase activity
NP165_RS04910	COG1757	Na H antiporter
NP165_RS04915	COG3457	Alanine racemase
NP165_RS04945	COG2824	Alkylphosphonate utilization operon protein PhnA
NP165_RS04950	COG0583	DNA-binding transcription factor activity
NP165_RS04975	COG4948	Mandelate Racemase Muconate Lactonizing
NP165_RS05030	COG0601	transmembrane transport
NP165_RS05035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP165_RS05040	COG0444	Belongs to the ABC transporter superfamily
NP165_RS05050	COG0435	Glutathione S-transferase
NP165_RS05055	COG3174	membrane
NP165_RS05060	COG0280	phosphate acetyltransferase
NP165_RS05060	COG0857	belongs to the CobB CobQ family
NP165_RS05065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP165_RS05070	COG3092	negative regulation of chromosome organization
NP165_RS05075	COG0686	Belongs to the AlaDH PNT family
NP165_RS05080	COG1522	sequence-specific DNA binding
NP165_RS05085	COG1674	ftsk spoiiie
NP165_RS05095	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NP165_RS05100	COG2186	Transcriptional regulator
NP165_RS05110	COG0537	adenosine 5'-monophosphoramidase activity
NP165_RS05135	COG3150	esterase
NP165_RS05140	COG1252	NADH dehydrogenase
NP165_RS05155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NP165_RS05165	COG4591	ABC-type transport system involved in lipoprotein release permease component
NP165_RS05170	COG1136	(ABC) transporter
NP165_RS05175	COG4591	ABC-type transport system involved in lipoprotein release permease component
NP165_RS05185	COG0658	competence protein
NP165_RS05185	COG2333	competence protein COMEC
NP165_RS05190	COG1132	(ABC) transporter
NP165_RS05200	COG2835	tetraacyldisaccharide 4'-kinase activity
NP165_RS05210	COG2719	SpoVR family
NP165_RS05215	COG2718	Belongs to the UPF0229 family
NP165_RS05220	COG2766	serine protein kinase
NP165_RS05225	COG3013	Belongs to the UPF0304 family
NP165_RS05235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NP165_RS05245	COG1882	Formate acetyltransferase
NP165_RS05280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NP165_RS05285	COG1737	Transcriptional regulator
NP165_RS05290	COG0076	glutamate decarboxylase activity
NP165_RS05300	COG2431	L-lysine efflux transmembrane transporter activity
NP165_RS05310	COG3070	regulator of competence-specific genes
NP165_RS05325	COG4191	Histidine kinase
NP165_RS05335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NP165_RS05340	COG1032	radical SAM domain protein
NP165_RS05360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP165_RS05380	COG0443	Heat shock 70 kDa protein
NP165_RS05385	COG0443	Heat shock 70 kDa protein
NP165_RS05395	COG3706	GGDEF domain
NP165_RS05430	COG1643	Atp-dependent helicase
NP165_RS05510	COG1301	dicarboxylic acid transport
NP165_RS05525	COG0159	tryptophan synthase activity
NP165_RS05530	COG0133	tryptophan synthase activity
NP165_RS05535	COG0134	indole-3-glycerol-phosphate synthase activity
NP165_RS05535	COG0135	phosphoribosylanthranilate isomerase activity
NP165_RS05540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NP165_RS05545	COG0512	Glutamine amidotransferase of anthranilate synthase
NP165_RS05550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP165_RS05565	COG0009	L-threonylcarbamoyladenylate synthase
NP165_RS05570	COG1187	pseudouridine synthase activity
NP165_RS05575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NP165_RS05580	COG4988	ABC transporter
NP165_RS05585	COG0492	ferredoxin-NADP+ reductase activity
NP165_RS05595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP165_RS05605	COG2949	membrane
NP165_RS05615	COG0281	malic enzyme
NP165_RS05620	COG1643	Atp-dependent helicase
NP165_RS05630	COG1448	Aminotransferase
NP165_RS05640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP165_RS05660	COG0017	Asparaginyl-tRNA synthetase
NP165_RS05665	COG0840	transmembrane signaling receptor activity
NP165_RS05670	COG0720	synthase
NP165_RS05680	COG0814	amino acid
NP165_RS05685	COG1760	l-serine dehydratase
NP165_RS05690	COG0814	amino acid
NP165_RS05695	COG0494	nUDIX hydrolase
NP165_RS05700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP165_RS05715	COG3106	COG3106 Predicted ATPase
NP165_RS05720	COG3768	UPF0283 membrane protein
NP165_RS05730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP165_RS05750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP165_RS05775	COG2989	Protein conserved in bacteria
NP165_RS05780	COG3108	Peptidase M15
NP165_RS05785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP165_RS05800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NP165_RS05840	COG0531	amino acid
NP165_RS05850	COG3501	Rhs element vgr protein
NP165_RS05895	COG1061	Type III restriction enzyme res subunit
NP165_RS05905	COG2814	Major facilitator Superfamily
NP165_RS05915	COG0702	epimerase
NP165_RS05920	COG0534	Mate efflux family protein
NP165_RS05925	COG1136	(ABC) transporter
NP165_RS05940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NP165_RS05965	COG0019	diaminopimelate decarboxylase activity
NP165_RS05980	COG1058	Belongs to the CinA family
NP165_RS05980	COG1546	Belongs to the CinA family
NP165_RS05995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP165_RS06000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP165_RS06005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP165_RS06015	COG3300	MHYT domain
NP165_RS06015	COG5001	Diguanylate cyclase
NP165_RS06025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NP165_RS06035	COG0584	glycerophosphoryl diester phosphodiesterase
NP165_RS06045	COG0039	L-malate dehydrogenase activity
NP165_RS06060	COG3290	protein histidine kinase activity
NP165_RS06065	COG4565	transcriptional regulatory protein
NP165_RS06080	COG0840	transmembrane signaling receptor activity
NP165_RS06100	COG0351	phosphomethylpyrimidine kinase
NP165_RS06105	COG1116	anion transmembrane transporter activity
NP165_RS06110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP165_RS06115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP165_RS06120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP165_RS06135	COG0546	phosphoglycolate phosphatase activity
NP165_RS06155	COG2610	gluconate transmembrane transporter activity
NP165_RS06165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP165_RS06170	COG3962	Belongs to the TPP enzyme family
NP165_RS06175	COG1454	alcohol dehydrogenase
NP165_RS06175	COG1012	belongs to the aldehyde dehydrogenase family
NP165_RS06185	COG1082	Xylose isomerase domain protein TIM barrel
NP165_RS06195	COG1082	Xylose isomerase domain protein TIM barrel
NP165_RS06200	COG0477	Major facilitator Superfamily
NP165_RS06200	COG2814	Major facilitator Superfamily
NP165_RS06205	COG0673	inositol 2-dehydrogenase activity
NP165_RS06210	COG3718	enzyme involved in inositol metabolism
NP165_RS06220	COG1454	alcohol dehydrogenase
NP165_RS06250	COG1793	dna ligase
NP165_RS06260	COG0534	Mate efflux family protein
NP165_RS06265	COG0307	riboflavin synthase, alpha
NP165_RS06275	COG3001	Fructosamine kinase
NP165_RS06285	COG0791	NLP P60 protein
NP165_RS06300	COG3148	PFAM DTW domain containing protein
NP165_RS06305	COG1940	carbohydrate kinase activity
NP165_RS06310	COG5001	Diguanylate cyclase
NP165_RS06320	COG0303	'Molybdopterin
NP165_RS06330	COG3842	ATPase activity
NP165_RS06335	COG4662	Binding-protein-dependent transport system inner membrane component
NP165_RS06345	COG2204	response regulator
NP165_RS06350	COG4191	Histidine kinase
NP165_RS06355	COG0488	(ABC) transporter
NP165_RS06360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP165_RS06390	COG0243	molybdopterin cofactor binding
NP165_RS06390	COG3383	formate dehydrogenase (NAD+) activity
NP165_RS06395	COG0437	4 iron, 4 sulfur cluster binding
NP165_RS06410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NP165_RS06425	COG1177	transmembrane transport
NP165_RS06435	COG3842	ATPase activity
NP165_RS06495	COG0589	response to stress
NP165_RS06500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP165_RS06515	COG2217	Heavy metal translocating P-type atpase
NP165_RS06525	COG2010	Cytochrome c
NP165_RS06540	COG3278	Belongs to the heme-copper respiratory oxidase family
NP165_RS06555	COG0784	Response regulator, receiver
NP165_RS06555	COG2205	protein histidine kinase activity
NP165_RS06570	COG0583	DNA-binding transcription factor activity
NP165_RS06615	COG1067	ATP-dependent peptidase activity
NP165_RS06620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP165_RS06635	COG0488	(ABC) transporter
NP165_RS06645	COG0116	Belongs to the methyltransferase superfamily
NP165_RS06645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP165_RS06660	COG2902	Dehydrogenase
NP165_RS06670	COG0308	aminopeptidase N
NP165_RS06685	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NP165_RS06690	COG1956	GAF domain-containing protein
NP165_RS06695	COG1132	(ABC) transporter
NP165_RS06700	COG2995	paraquat-inducible protein a
NP165_RS06705	COG3008	intermembrane lipid transfer
NP165_RS06710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP165_RS06710	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NP165_RS06735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NP165_RS06745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP165_RS06745	COG1648	precorrin-2 dehydrogenase activity
NP165_RS06750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP165_RS06755	COG4597	amino acid ABC transporter
NP165_RS06760	COG0765	amino acid transport
NP165_RS06765	COG1126	abc transporter atp-binding protein
NP165_RS06770	COG0670	Belongs to the BI1 family
NP165_RS06775	COG2920	part of a sulfur-relay system
NP165_RS06780	COG1254	Belongs to the acylphosphatase family
NP165_RS06785	COG0840	transmembrane signaling receptor activity
NP165_RS06790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP165_RS06930	COG2885	chlorophyll binding
NP165_RS06940	COG3706	GGDEF domain
NP165_RS06945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NP165_RS06950	COG0602	queuosine metabolic process
NP165_RS06975	COG2828	Protein conserved in bacteria
NP165_RS06985	COG0372	Belongs to the citrate synthase family
NP165_RS06990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NP165_RS07025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP165_RS07055	COG1278	Cold shock
NP165_RS07075	COG3122	Protein conserved in bacteria
NP165_RS07095	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NP165_RS07100	COG3063	Type IV pilus biogenesis stability protein PilW
NP165_RS07105	COG1846	Transcriptional regulator
NP165_RS07110	COG2130	NADP-dependent
NP165_RS07120	COG1451	nucleotide metabolic process
NP165_RS07130	COG1119	ATPase activity
NP165_RS07135	COG0583	DNA-binding transcription factor activity
NP165_RS07140	COG2814	Major facilitator Superfamily
NP165_RS07155	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
NP165_RS07160	COG4139	cobalamin transport
NP165_RS07185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NP165_RS07190	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NP165_RS07195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP165_RS07205	COG1823	symporter activity
NP165_RS07210	COG2925	Exonuclease
NP165_RS07215	COG1380	Effector of murein hydrolase LrgA
NP165_RS07220	COG1346	cytolysis
NP165_RS07225	COG0295	cytidine deaminase activity
NP165_RS07230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NP165_RS07245	COG4326	sporulation control protein
NP165_RS07250	COG2188	Transcriptional regulator
NP165_RS07255	COG1228	amidohydrolase
NP165_RS07260	COG0010	Belongs to the arginase family
NP165_RS07265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NP165_RS07270	COG2986	histidine ammonia-lyase
NP165_RS07280	COG2020	methyltransferase activity
NP165_RS07285	COG0277	FAD linked oxidase domain protein
NP165_RS07285	COG0247	lactate metabolic process
NP165_RS07300	COG2885	chlorophyll binding
NP165_RS07315	COG0625	glutathione transferase activity
NP165_RS07325	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NP165_RS07335	COG1280	lysine exporter protein (LysE YggA)
NP165_RS07375	COG1115	amino acid carrier protein
NP165_RS07385	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NP165_RS07395	COG0348	domain, Protein
NP165_RS07395	COG3901	Regulator of nitric oxide reductase transcription
NP165_RS07410	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NP165_RS07435	COG2205	protein histidine kinase activity
NP165_RS07475	COG1131	(ABC) transporter
NP165_RS07495	COG0625	glutathione transferase activity
NP165_RS07505	COG0583	DNA-binding transcription factor activity
NP165_RS07510	COG0534	Mate efflux family protein
NP165_RS07520	COG0072	phenylalanine-tRNA ligase activity
NP165_RS07520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP165_RS07530	COG0456	acetyltransferase
NP165_RS07555	COG2133	pyrroloquinoline quinone binding
NP165_RS07585	COG0322	excinuclease ABC activity
NP165_RS07590	COG2197	response regulator
NP165_RS07605	COG0417	DNA replication proofreading
NP165_RS07625	COG0776	regulation of translation
NP165_RS07640	COG2350	Protein conserved in bacteria
NP165_RS07655	COG3313	Fe-S protein
NP165_RS07665	COG4134	Bacterial extracellular solute-binding protein
NP165_RS07670	COG4135	transport system, permease component
NP165_RS07675	COG4136	ATPase activity
NP165_RS07680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP165_RS07690	COG0564	pseudouridine synthase activity
NP165_RS07695	COG0733	neurotransmitter:sodium symporter activity
NP165_RS07705	COG0626	cystathionine gamma-synthase activity
NP165_RS07710	COG2818	Glycosylase
NP165_RS07725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP165_RS07740	COG1842	Phage shock protein A
NP165_RS07745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP165_RS07755	COG4168	peptide transport system, permease
NP165_RS07760	COG4171	peptide transport system, permease
NP165_RS07770	COG4172	Belongs to the ABC transporter superfamily
NP165_RS07780	COG1227	inorganic diphosphatase activity
NP165_RS07790	COG0217	transcriptional regulatory protein
NP165_RS07805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NP165_RS07810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NP165_RS07815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NP165_RS07815	COG0131	Imidazoleglycerol-phosphate dehydratase
NP165_RS07820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NP165_RS07825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP165_RS07835	COG1757	Na H antiporter
NP165_RS07845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP165_RS07865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NP165_RS07875	COG2268	Band 7 protein
NP165_RS07885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NP165_RS07900	COG0300	oxidoreductase activity
NP165_RS07910	COG0501	Belongs to the peptidase M48B family
NP165_RS07920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NP165_RS07925	COG2226	methyltransferase
NP165_RS07930	COG0156	8-amino-7-oxononanoate synthase activity
NP165_RS07935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NP165_RS07940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP165_RS07945	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NP165_RS07950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NP165_RS07955	COG1199	ATP-dependent helicase activity
NP165_RS07960	COG3923	Primosomal replication protein n
NP165_RS07970	COG2850	peptidyl-arginine hydroxylation
NP165_RS07975	COG0708	Exodeoxyribonuclease III
NP165_RS07980	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP165_RS07985	COG1960	acyl-CoA dehydrogenase activity
NP165_RS08005	COG0579	oxidoreductase
NP165_RS08045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NP165_RS08045	COG0678	peroxiredoxin activity
NP165_RS08065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NP165_RS08070	COG1012	belongs to the aldehyde dehydrogenase family
NP165_RS08075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP165_RS08080	COG1012	belongs to the aldehyde dehydrogenase family
NP165_RS08085	COG2267	carboxylic ester hydrolase activity
NP165_RS08100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP165_RS08110	COG2186	Transcriptional regulator
NP165_RS08195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NP165_RS08200	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NP165_RS08205	COG2885	chlorophyll binding
NP165_RS08210	COG0823	Involved in the tonB-independent uptake of proteins
NP165_RS08225	COG0811	peptide transport
NP165_RS08230	COG0824	Thioesterase
NP165_RS08240	COG4890	Cyd operon protein YbgT
NP165_RS08245	COG1294	oxidase, subunit
NP165_RS08250	COG1271	oxidase subunit
NP165_RS08255	COG2255	four-way junction helicase activity
NP165_RS08260	COG0632	four-way junction helicase activity
NP165_RS08265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NP165_RS08270	COG0243	molybdopterin cofactor binding
NP165_RS08275	COG3005	denitrification pathway
NP165_RS08280	COG4459	periplasmic nitrate reductase
NP165_RS08285	COG0390	transport system, permease component
NP165_RS08305	COG0542	response to heat
NP165_RS08310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NP165_RS08315	COG1278	Cold shock
NP165_RS08325	COG1187	pseudouridine synthase activity
NP165_RS08335	COG1801	Protein of unknown function DUF72
NP165_RS08345	COG0500	methyltransferase
NP165_RS08350	COG4067	protein conserved in archaea
NP165_RS08350	COG0189	ligase activity
NP165_RS08365	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NP165_RS08370	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NP165_RS08375	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
NP165_RS08380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP165_RS08385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NP165_RS08390	COG0745	RESPONSE REGULATOR receiver
NP165_RS08400	COG1609	Transcriptional regulator
NP165_RS08405	COG3070	regulator of competence-specific genes
NP165_RS08425	COG0297	glycogen (starch) synthase activity
NP165_RS08430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP165_RS08435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP165_RS08455	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NP165_RS08460	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NP165_RS08465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NP165_RS08470	COG1435	thymidine kinase activity
NP165_RS08475	COG0215	cysteine-tRNA ligase activity
NP165_RS08480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP165_RS08485	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NP165_RS08490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP165_RS08495	COG3012	SEC-C Motif Domain Protein
NP165_RS08500	COG3139	Protein of unknown function (DUF1315)
NP165_RS08510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP165_RS08530	COG2204	response regulator
NP165_RS08535	COG0471	metal ion transport
NP165_RS08540	COG2226	methyltransferase
NP165_RS08555	COG1785	Belongs to the alkaline phosphatase family
NP165_RS08560	COG0668	transmembrane transport
NP165_RS08565	COG2983	Belongs to the UPF0260 family
NP165_RS08575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NP165_RS08580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NP165_RS08595	COG2832	Protein of unknown function (DUF454)
NP165_RS08600	COG0745	RESPONSE REGULATOR receiver
NP165_RS08605	COG0583	DNA-binding transcription factor activity
NP165_RS08610	COG0778	Nitroreductase
NP165_RS08615	COG1024	Enoyl-CoA hydratase
NP165_RS08615	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP165_RS08620	COG0183	Belongs to the thiolase family
NP165_RS08625	COG1595	DNA-templated transcription, initiation
NP165_RS08640	COG2067	long-chain fatty acid transport protein
NP165_RS08650	COG4235	cytochrome complex assembly
NP165_RS08650	COG3088	subunit of a heme lyase
NP165_RS08660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP165_RS08665	COG1138	Cytochrome C-type biogenesis protein
NP165_RS08670	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NP165_RS08675	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP165_RS08680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP165_RS08685	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP165_RS08700	COG0835	chemotaxis
NP165_RS08710	COG1192	Involved in chromosome partitioning
NP165_RS08715	COG2201	protein-glutamate methylesterase activity
NP165_RS08720	COG2198	Histidine kinase
NP165_RS08720	COG0643	Histidine kinase
NP165_RS08720	COG0784	Response regulator, receiver
NP165_RS08725	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NP165_RS08755	COG2062	phosphohistidine phosphatase, SixA
NP165_RS08765	COG3102	Protein conserved in bacteria
NP165_RS08770	COG0018	arginyl-trna synthetase
NP165_RS08790	COG1918	ferrous iron import across plasma membrane
NP165_RS08795	COG4977	sequence-specific DNA binding
NP165_RS08800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NP165_RS08805	COG1121	(ABC) transporter
NP165_RS08810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP165_RS08815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NP165_RS08820	COG1286	toxin biosynthetic process
NP165_RS08825	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NP165_RS08830	COG0285	dihydrofolate synthase activity
NP165_RS08835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NP165_RS08840	COG0101	tRNA pseudouridine synthase activity
NP165_RS08850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP165_RS08855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP165_RS08860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP165_RS08875	COG3101	peptidyl-lysine hydroxylation
NP165_RS08880	COG2860	membrane
NP165_RS08885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NP165_RS08890	COG2890	protein-(glutamine-N5) methyltransferase activity
NP165_RS08895	COG2840	Smr protein MutS2
NP165_RS08905	COG1684	flagellar biosynthetic protein fliR
NP165_RS08910	COG1987	bacterial-type flagellum assembly
NP165_RS08935	COG1580	Controls the rotational direction of flagella during chemotaxis
NP165_RS08960	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP165_RS08970	COG1677	Flagellar hook-basal body complex protein FliE
NP165_RS08990	COG1516	flagellar protein fliS
NP165_RS09000	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NP165_RS09010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP165_RS09025	COG2837	iron assimilation
NP165_RS09035	COG4235	cytochrome complex assembly
NP165_RS09035	COG3088	subunit of a heme lyase
NP165_RS09045	COG1138	Cytochrome C-type biogenesis protein
NP165_RS09050	COG3301	Polysulphide reductase, NrfD
NP165_RS09055	COG0437	4 iron, 4 sulfur cluster binding
NP165_RS09065	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NP165_RS09070	COG4235	cytochrome complex assembly
NP165_RS09085	COG1393	Belongs to the ArsC family
NP165_RS09090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP165_RS09095	COG1876	peptidase activity
NP165_RS09105	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NP165_RS09115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP165_RS09115	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP165_RS09130	COG1611	Belongs to the LOG family
NP165_RS09135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP165_RS09140	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NP165_RS09145	COG2363	Small membrane protein
NP165_RS09155	COG0583	DNA-binding transcription factor activity
NP165_RS09160	COG0109	protoheme IX farnesyltransferase activity
NP165_RS09165	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP165_RS09170	COG1845	cytochrome c oxidase, subunit III
NP165_RS09175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP165_RS09180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP165_RS09185	COG0301	tRNA thio-modification
NP165_RS09185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP165_RS09195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP165_RS09205	COG0142	geranyltranstransferase activity
NP165_RS09210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NP165_RS09215	COG0564	pseudouridine synthase activity
NP165_RS09220	COG3098	single-species biofilm formation
NP165_RS09250	COG0045	succinate-CoA ligase (ADP-forming) activity
NP165_RS09255	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP165_RS09260	COG0567	Dehydrogenase, E1 component
NP165_RS09270	COG1053	succinate dehydrogenase
NP165_RS09275	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NP165_RS09290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NP165_RS09300	COG0033	Phosphoglucomutase
NP165_RS09305	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NP165_RS09310	COG0596	Alpha beta hydrolase
NP165_RS09320	COG0716	FMN binding
NP165_RS09330	COG0735	belongs to the Fur family
NP165_RS09335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP165_RS09340	COG2190	(PTS) system
NP165_RS09340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP165_RS09340	COG1263	PTS System
NP165_RS09345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NP165_RS09350	COG1940	carbohydrate kinase activity
NP165_RS09350	COG1846	Transcriptional regulator
NP165_RS09355	COG4651	solute:proton antiporter activity
NP165_RS09355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NP165_RS09360	COG0367	asparagine synthase
NP165_RS09370	COG3104	oligopeptide transport
NP165_RS09390	COG2840	Smr protein MutS2
NP165_RS09395	COG1187	pseudouridine synthase activity
NP165_RS09400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NP165_RS09405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NP165_RS09410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NP165_RS09435	COG0047	phosphoribosylformylglycinamidine synthase activity
NP165_RS09435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP165_RS09440	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NP165_RS09450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NP165_RS09480	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NP165_RS09495	COG1720	tRNA m6t6A37 methyltransferase activity
NP165_RS09505	COG0121	glutamine amidotransferase
NP165_RS09510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NP165_RS09515	COG1960	acyl-CoA dehydrogenase activity
NP165_RS09530	COG0328	RNA-DNA hybrid ribonuclease activity
NP165_RS09535	COG2226	methyltransferase
NP165_RS09540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP165_RS09545	COG0741	lytic transglycosylase activity
NP165_RS09545	COG1388	LysM domain
NP165_RS09555	COG3021	interspecies interaction between organisms
NP165_RS09560	COG0347	Belongs to the P(II) protein family
NP165_RS09570	COG0037	tRNA processing
NP165_RS09575	COG0484	heat shock protein binding
NP165_RS09585	COG1301	dicarboxylic acid transport
NP165_RS09590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NP165_RS09600	COG0497	DNA recombination
NP165_RS09605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP165_RS09610	COG2914	Belongs to the UPF0125 (RnfH) family
NP165_RS09615	COG2867	negative regulation of translational initiation
NP165_RS09620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NP165_RS09630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NP165_RS09635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP165_RS09635	COG3153	acetyltransferase
NP165_RS09640	COG2873	o-acetylhomoserine
NP165_RS09655	COG0583	DNA-binding transcription factor activity
NP165_RS09660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP165_RS09665	COG1115	amino acid carrier protein
NP165_RS09675	COG1473	amidohydrolase
NP165_RS09685	COG1584	GPR1 FUN34 yaaH family protein
NP165_RS09695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NP165_RS09695	COG0519	Catalyzes the synthesis of GMP from XMP
NP165_RS09700	COG0516	GMP reductase activity
NP165_RS09700	COG0517	IMP dehydrogenase activity
NP165_RS09705	COG1570	exodeoxyribonuclease VII activity
NP165_RS09720	COG3290	protein histidine kinase activity
NP165_RS09725	COG0471	metal ion transport
NP165_RS09735	COG1160	GTP binding
NP165_RS09740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP165_RS09745	COG2976	Protein conserved in bacteria
NP165_RS09750	COG0124	histidyl-tRNA synthetase
NP165_RS09755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NP165_RS09760	COG1426	Protein conserved in bacteria
NP165_RS09770	COG2166	iron-sulfur cluster assembly
NP165_RS09775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NP165_RS09780	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NP165_RS09795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NP165_RS09800	COG1074	ATP-dependent DNA helicase activity
NP165_RS09805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NP165_RS09815	COG3141	response to X-ray
NP165_RS09820	COG3142	Participates in the control of copper homeostasis
NP165_RS09830	COG0704	Plays a role in the regulation of phosphate uptake
NP165_RS09835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP165_RS09840	COG0581	inorganic phosphate transmembrane transporter activity
NP165_RS09845	COG0573	inorganic phosphate transmembrane transporter activity
NP165_RS09850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NP165_RS09855	COG0248	Ppx GppA phosphatase
NP165_RS09865	COG5002	protein histidine kinase activity
NP165_RS09870	COG0745	RESPONSE REGULATOR receiver
NP165_RS09880	COG2895	sulfate adenylyltransferase (ATP) activity
NP165_RS09890	COG0529	Catalyzes the synthesis of activated sulfate
NP165_RS09895	COG0175	sulfate reduction
NP165_RS09900	COG0471	metal ion transport
NP165_RS09900	COG0490	domain, Protein
NP165_RS09955	COG3754	Rhamnan synthesis protein F
NP165_RS09960	COG1088	dTDP-glucose 4,6-dehydratase activity
NP165_RS09965	COG1091	dTDP-4-dehydrorhamnose reductase activity
NP165_RS10025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP165_RS10030	COG0826	peptidase U32
NP165_RS10035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NP165_RS10045	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
NP165_RS10055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP165_RS10060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP165_RS10065	COG1862	Preprotein translocase
NP165_RS10070	COG0343	queuine tRNA-ribosyltransferase activity
NP165_RS10075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NP165_RS10080	COG0517	IMP dehydrogenase activity
NP165_RS10085	COG1609	Transcriptional regulator
NP165_RS10090	COG1621	beta-fructofuranosidase activity
NP165_RS10095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP165_RS10095	COG1263	PTS System
NP165_RS10100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP165_RS10110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NP165_RS10115	COG0583	DNA-binding transcription factor activity
NP165_RS10120	COG0450	alkyl hydroperoxide reductase
NP165_RS10125	COG2171	N-acyltransferase activity
NP165_RS10140	COG1309	transcriptional regulator
NP165_RS10145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NP165_RS10150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP165_RS10155	COG1349	DNA-binding transcription factor activity
NP165_RS10160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NP165_RS10230	COG4964	Belongs to the GSP D family
NP165_RS10245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NP165_RS10255	COG2207	Transcriptional regulator
NP165_RS10260	COG1022	Amp-dependent synthetase and ligase
NP165_RS10265	COG0583	DNA-binding transcription factor activity
NP165_RS10275	COG0583	DNA-binding transcription factor activity
NP165_RS10280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP165_RS10285	COG0105	UTP biosynthetic process
NP165_RS10295	COG2975	iron-sulfur cluster assembly
NP165_RS10300	COG0633	Ferredoxin
NP165_RS10305	COG0443	Heat shock 70 kDa protein
NP165_RS10320	COG0822	iron-sulfur transferase activity
NP165_RS10325	COG1104	cysteine desulfurase activity
NP165_RS10335	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NP165_RS10340	COG0483	inositol monophosphate 1-phosphatase activity
NP165_RS10355	COG3335	DDE superfamily endonuclease
NP165_RS10365	COG3335	DDE superfamily endonuclease
NP165_RS10405	COG0542	response to heat
NP165_RS10410	COG1496	oxidoreductase activity
NP165_RS10415	COG0564	pseudouridine synthase activity
NP165_RS10420	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP165_RS10425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP165_RS10430	COG1605	Chorismate mutase
NP165_RS10430	COG0077	Prephenate dehydratase
NP165_RS10435	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
NP165_RS10440	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
NP165_RS10450	COG0488	(ABC) transporter
NP165_RS10460	COG0739	heme binding
NP165_RS10465	COG0287	Prephenate dehydrogenase
NP165_RS10465	COG1605	Chorismate mutase
NP165_RS10470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NP165_RS10475	COG3275	phosphorelay sensor kinase activity
NP165_RS10480	COG3279	Response regulator of the LytR AlgR family
NP165_RS10490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NP165_RS10495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NP165_RS10505	COG1966	Carbon starvation protein
NP165_RS10510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NP165_RS10515	COG1047	Peptidyl-prolyl cis-trans
NP165_RS10520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NP165_RS10525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP165_RS10530	COG0196	riboflavin kinase activity
NP165_RS10535	COG0728	peptidoglycan biosynthetic process
NP165_RS10540	COG0268	Binds directly to 16S ribosomal RNA
NP165_RS10545	COG0640	Transcriptional regulator
NP165_RS10550	COG0583	DNA-binding transcription factor activity
NP165_RS10555	COG1283	sodium-dependent phosphate transmembrane transporter activity
NP165_RS10565	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NP165_RS10570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NP165_RS10575	COG0730	response to heat
NP165_RS10585	COG0494	nUDIX hydrolase
NP165_RS10590	COG3066	DNA modification
NP165_RS10600	COG0667	Aldo Keto reductase
NP165_RS10630	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NP165_RS10635	COG0513	Belongs to the DEAD box helicase family
NP165_RS10640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NP165_RS10650	COG0456	acetyltransferase
NP165_RS10660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP165_RS10665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP165_RS10670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP165_RS10675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NP165_RS10680	COG1534	Rna-binding protein
NP165_RS10685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP165_RS10690	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NP165_RS10695	COG2027	D-alanyl-D-alanine carboxypeptidase
NP165_RS10700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP165_RS10705	COG0739	heme binding
NP165_RS10720	COG0316	Belongs to the HesB IscA family
NP165_RS10725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP165_RS10730	COG0628	permease
NP165_RS10740	COG2205	protein histidine kinase activity
NP165_RS10740	COG0784	Response regulator, receiver
NP165_RS10755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP165_RS10760	COG0444	Belongs to the ABC transporter superfamily
NP165_RS10765	COG4608	Belongs to the ABC transporter superfamily
NP165_RS10775	COG2971	BadF BadG BcrA BcrD
NP165_RS10790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP165_RS10795	COG3385	transposase activity
NP165_RS10800	COG3842	ATPase activity
NP165_RS10810	COG1840	ABC-type Fe3 transport system, periplasmic component
NP165_RS10815	COG0004	ammonium transporteR
NP165_RS10825	COG3112	Uncharacterised protein family (UPF0231)
NP165_RS10830	COG3835	regulator
NP165_RS10835	COG2610	gluconate transmembrane transporter activity
NP165_RS10840	COG1929	Belongs to the glycerate kinase type-1 family
NP165_RS10845	COG1049	propionate catabolic process, 2-methylcitrate cycle
NP165_RS10850	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP165_RS10855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP165_RS10860	COG1643	Atp-dependent helicase
NP165_RS10870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP165_RS10875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP165_RS10885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP165_RS10900	COG0842	Transport permease protein
NP165_RS10905	COG1131	(ABC) transporter
NP165_RS10910	COG0659	secondary active sulfate transmembrane transporter activity
NP165_RS10915	COG0288	reversible hydration of carbon dioxide
NP165_RS10930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP165_RS10935	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP165_RS10940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NP165_RS10945	COG2186	Transcriptional regulator
NP165_RS10950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NP165_RS10955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP165_RS10960	COG4974	Belongs to the 'phage' integrase family
NP165_RS10965	COG0716	FMN binding
NP165_RS10975	COG0157	Belongs to the NadC ModD family
NP165_RS10980	COG4969	Belongs to the N-Me-Phe pilin family
NP165_RS10985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP165_RS10990	COG1459	type II secretion system
NP165_RS11000	COG0237	dephospho-CoA kinase activity
NP165_RS11005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NP165_RS11010	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NP165_RS11020	COG0336	Belongs to the RNA methyltransferase TrmD family
NP165_RS11030	COG0228	four-way junction DNA binding
NP165_RS11035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NP165_RS11040	COG4137	Cytochrome C assembly protein
NP165_RS11045	COG4536	flavin adenine dinucleotide binding
NP165_RS11050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NP165_RS11055	COG1388	LysM domain
NP165_RS11055	COG4942	peptidase
NP165_RS11075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NP165_RS11080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NP165_RS11085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NP165_RS11090	COG1968	undecaprenyl-diphosphatase activity
NP165_RS11095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP165_RS11100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NP165_RS11105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NP165_RS11110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NP165_RS11115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NP165_RS11120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NP165_RS11125	COG1610	YqeY-like protein
NP165_RS11240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP165_RS11250	COG3550	peptidyl-serine autophosphorylation
NP165_RS11260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NP165_RS11265	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NP165_RS11275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NP165_RS11280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NP165_RS11285	COG2967	ApaG domain
NP165_RS11300	COG3610	response to peptide
NP165_RS11305	COG3610	response to peptide
NP165_RS11310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NP165_RS11315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NP165_RS11320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NP165_RS11325	COG0142	geranyltranstransferase activity
NP165_RS11335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NP165_RS11340	COG2213	PTS system mannitol-specific
NP165_RS11340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP165_RS11345	COG0246	Mannitol dehydrogenase
NP165_RS11350	COG3722	fumarate hydratase activity
NP165_RS11355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NP165_RS11360	COG1349	DNA-binding transcription factor activity
NP165_RS11365	COG0469	pyruvate kinase activity
NP165_RS11375	COG0668	transmembrane transport
NP165_RS11380	COG0191	fructose-bisphosphate aldolase activity
NP165_RS11385	COG0126	phosphoglycerate kinase activity
NP165_RS11390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP165_RS11395	COG4771	TonB-dependent receptor
NP165_RS11400	COG0583	DNA-binding transcription factor activity
NP165_RS11410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP165_RS11415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NP165_RS11430	COG2356	endonuclease I
NP165_RS11435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NP165_RS11440	COG0189	ligase activity
NP165_RS11445	COG1678	Uncharacterized ACR, COG1678
NP165_RS11450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NP165_RS11465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NP165_RS11470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP165_RS11475	COG0762	integral membrane protein
NP165_RS11490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NP165_RS11495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP165_RS11505	COG2066	Belongs to the glutaminase family
NP165_RS11510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NP165_RS11520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NP165_RS11575	COG0204	Acyl-transferase
NP165_RS11580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP165_RS11585	COG5007	Belongs to the BolA IbaG family
NP165_RS11595	COG2854	intermembrane phospholipid transfer
NP165_RS11600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NP165_RS11605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NP165_RS11610	COG1127	ABC transporter
NP165_RS11620	COG0517	IMP dehydrogenase activity
NP165_RS11620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NP165_RS11625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NP165_RS11635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NP165_RS11640	COG1137	ATPase activity
NP165_RS11650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP165_RS11655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP165_RS11660	COG1660	Displays ATPase and GTPase activities
NP165_RS11665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP165_RS11670	COG2239	Acts as a magnesium transporter
NP165_RS11675	COG0646	methionine synthase
NP165_RS11675	COG1410	methionine synthase
NP165_RS11710	COG3335	DDE superfamily endonuclease
NP165_RS11720	COG3335	DDE superfamily endonuclease
NP165_RS11780	COG0175	sulfate reduction
NP165_RS11785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP165_RS11790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP165_RS11810	COG0735	belongs to the Fur family
NP165_RS11820	COG0529	Catalyzes the synthesis of activated sulfate
NP165_RS11825	COG0471	metal ion transport
NP165_RS11825	COG3273	potassium ion transport
NP165_RS11840	COG1648	precorrin-2 dehydrogenase activity
NP165_RS11840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP165_RS11845	COG0737	Belongs to the 5'-nucleotidase family
NP165_RS11855	COG2153	protein acetylation
NP165_RS11860	COG0697	spore germination
NP165_RS11870	COG0545	Peptidyl-prolyl cis-trans isomerase
NP165_RS11880	COG0203	ribosomal protein L17
NP165_RS11885	COG0202	RNA polymerase activity
NP165_RS11895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NP165_RS11900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NP165_RS11905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NP165_RS11910	COG0201	protein transport
NP165_RS11915	COG0200	Binds to the 23S rRNA
NP165_RS11920	COG1841	ribosomal large subunit assembly
NP165_RS11935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NP165_RS11940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NP165_RS11945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NP165_RS11950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NP165_RS11955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NP165_RS11965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NP165_RS11980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NP165_RS11985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NP165_RS11990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NP165_RS12005	COG0088	Forms part of the polypeptide exit tunnel
NP165_RS12010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NP165_RS12020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP165_RS12025	COG0557	exoribonuclease II activity
NP165_RS12030	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NP165_RS12035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NP165_RS12040	COG1446	asparaginase
NP165_RS12045	COG1047	Peptidyl-prolyl cis-trans
NP165_RS12050	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NP165_RS12060	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP165_RS12065	COG0488	(ABC) transporter
NP165_RS12075	COG0429	hydrolase of the alpha beta-hydrolase fold
NP165_RS12080	COG3089	Belongs to the UPF0270 family
NP165_RS12085	COG3954	Phosphoribulokinase
NP165_RS12090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP165_RS12100	COG1012	belongs to the aldehyde dehydrogenase family
NP165_RS12110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP165_RS12115	COG0512	Glutamine amidotransferase of anthranilate synthase
NP165_RS12120	COG1473	amidohydrolase
NP165_RS12135	COG1027	Aspartate ammonia-lyase
NP165_RS12140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NP165_RS12145	COG1288	antiporter activity
NP165_RS12160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NP165_RS12170	COG0540	Belongs to the ATCase OTCase family
NP165_RS12175	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NP165_RS12180	COG1438	arginine binding
NP165_RS12185	COG4232	protein-disulfide reductase activity
NP165_RS12195	COG2095	MarC family integral membrane protein
NP165_RS12205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP165_RS12215	COG0784	Response regulator, receiver
NP165_RS12215	COG2198	Histidine kinase
NP165_RS12215	COG2205	protein histidine kinase activity
NP165_RS12220	COG2814	Major facilitator Superfamily
NP165_RS12235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP165_RS12240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NP165_RS12245	COG0511	ligase activity, forming carbon-carbon bonds
NP165_RS12250	COG0439	Biotin carboxylase
NP165_RS12255	COG2264	protein methyltransferase activity
NP165_RS12260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP165_RS12265	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NP165_RS12270	COG0789	Transcriptional regulator
NP165_RS12275	COG0138	bifunctional purine biosynthesis protein purh
NP165_RS12280	COG0151	Belongs to the GarS family
NP165_RS12310	COG1253	flavin adenine dinucleotide binding
NP165_RS12320	COG1573	uracil-dna glycosylase
NP165_RS12340	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
NP165_RS12345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP165_RS12355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NP165_RS12360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NP165_RS12360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NP165_RS12370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP165_RS12375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NP165_RS12375	COG0517	IMP dehydrogenase activity
NP165_RS12380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NP165_RS12385	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NP165_RS12390	COG1216	Glycosyl transferase, family 2
NP165_RS12410	COG3562	capsule polysaccharide
NP165_RS12430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP165_RS12435	COG1560	Kdo2-lipid A biosynthetic process
NP165_RS12445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NP165_RS12450	COG0859	PFAM glycosyl transferase family 9
NP165_RS12460	COG3642	lipopolysaccharide core region biosynthetic process
NP165_RS12465	COG4641	Protein conserved in bacteria
NP165_RS12465	COG0438	transferase activity, transferring glycosyl groups
NP165_RS12480	COG1519	Transferase
NP165_RS12525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NP165_RS12530	COG2003	Belongs to the UPF0758 family
NP165_RS12535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP165_RS12540	COG1309	transcriptional regulator
NP165_RS12545	COG1560	Kdo2-lipid A biosynthetic process
NP165_RS12550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NP165_RS12555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NP165_RS12560	COG1561	YicC-like family, N-terminal region
NP165_RS12570	COG2252	PERMEase
NP165_RS12575	COG0194	GDP metabolic process
NP165_RS12580	COG1758	RNA polymerase activity
NP165_RS12585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP165_RS12590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP165_RS12595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NP165_RS12600	COG1218	3'(2'),5'-bisphosphate nucleotidase
NP165_RS12605	COG0494	nUDIX hydrolase
NP165_RS12630	COG2183	response to ionizing radiation
NP165_RS12635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP165_RS12655	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NP165_RS12660	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NP165_RS12665	COG3156	type II secretion system protein K
NP165_RS12670	COG4795	General secretion pathway protein
NP165_RS12675	COG2165	general secretion pathway protein
NP165_RS12680	COG2165	general secretion pathway protein
NP165_RS12685	COG2165	general secretion pathway protein
NP165_RS12690	COG1459	type II secretion system
NP165_RS12695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP165_RS12705	COG3031	protein transport across the cell outer membrane
NP165_RS12710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NP165_RS12715	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NP165_RS12720	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NP165_RS12730	COG0456	acetyltransferase
NP165_RS12735	COG1490	D-aminoacyl-tRNA deacylase activity
NP165_RS12740	COG1295	ribonuclease BN
NP165_RS12755	COG1217	gtp-binding protein TYPA
NP165_RS12760	COG0174	glutamine synthetase
NP165_RS12770	COG3852	Histidine kinase
NP165_RS12780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NP165_RS12820	COG1309	transcriptional regulator
NP165_RS12825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP165_RS12830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP165_RS12835	COG2960	long-chain fatty acid transporting porin activity
NP165_RS12840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NP165_RS12845	COG0583	DNA-binding transcription factor activity
NP165_RS12880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP165_RS12880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP165_RS12895	COG0084	hydrolase, TatD family'
NP165_RS12900	COG0805	protein transport
NP165_RS12905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP165_RS12925	COG2226	methyltransferase
NP165_RS12930	COG1322	Protein conserved in bacteria
NP165_RS12940	COG2081	HI0933 family
NP165_RS12950	COG1528	Iron-storage protein
NP165_RS12955	COG0589	response to stress
NP165_RS12970	COG0742	ribosomal rna small subunit methyltransferase
NP165_RS12975	COG1522	sequence-specific DNA binding
NP165_RS12985	COG2814	Major facilitator Superfamily
NP165_RS12995	COG0006	proline dipeptidase activity
NP165_RS12995	COG0006	proline dipeptidase activity
NP165_RS13005	COG2022	thiamine diphosphate biosynthetic process
NP165_RS13015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP165_RS13025	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NP165_RS13030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP165_RS13040	COG3335	DDE superfamily endonuclease
NP165_RS13115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP165_RS13120	COG1739	Uncharacterized protein family UPF0029
NP165_RS13125	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP165_RS13125	COG1024	Enoyl-CoA hydratase
NP165_RS13130	COG0183	Belongs to the thiolase family
NP165_RS13135	COG0583	DNA-binding transcription factor activity
NP165_RS13140	COG2814	Major facilitator Superfamily
NP165_RS13150	COG0765	amino acid transport
NP165_RS13160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NP165_RS13165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP165_RS13170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NP165_RS13180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP165_RS13195	COG0356	it plays a direct role in the translocation of protons across the membrane
NP165_RS13200	COG3312	ion transport
NP165_RS13205	COG1475	DNA binding
NP165_RS13210	COG1192	Involved in chromosome partitioning
NP165_RS13215	COG0357	Ribosomal RNA small subunit methyltransferase G
NP165_RS13220	COG0445	tRNA wobble uridine modification
NP165_RS13225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP165_RS13235	COG0706	membrane insertase activity
NP165_RS13245	COG0594	ribonuclease P activity
NP165_RS13255	COG1126	abc transporter atp-binding protein
NP165_RS13275	COG1105	Belongs to the carbohydrate kinase PfkB family
NP165_RS13280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP165_RS13280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP165_RS13285	COG1609	Transcriptional regulator
NP165_RS13295	COG1492	cobalamin metabolic process
NP165_RS13300	COG0725	ABC transporter, periplasmic molybdate-binding protein
NP165_RS13305	COG4149	molybdate abc transporter
NP165_RS13310	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NP165_RS13320	COG3706	GGDEF domain
NP165_RS13325	COG3706	GGDEF domain
NP165_RS13340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NP165_RS13345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NP165_RS13355	COG0745	RESPONSE REGULATOR receiver
NP165_RS13370	COG3140	Belongs to the UPF0181 family
NP165_RS13385	COG0023	Translation Initiation Factor
NP165_RS13400	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP165_RS13410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP165_RS13410	COG1042	CoA-binding domain protein
NP165_RS13410	COG0045	succinate-CoA ligase (ADP-forming) activity
NP165_RS13415	COG0583	DNA-binding transcription factor activity
NP165_RS13435	COG2050	protein possibly involved in aromatic compounds catabolism
NP165_RS13460	COG0737	Belongs to the 5'-nucleotidase family
NP165_RS13465	COG3593	DNA synthesis involved in DNA repair
NP165_RS13475	COG0583	DNA-binding transcription factor activity
NP165_RS13480	COG2116	formate transmembrane transporter activity
NP165_RS13490	COG3038	cytochrome b561
NP165_RS13510	COG2197	response regulator
NP165_RS13515	COG3850	Histidine kinase
NP165_RS13530	COG0243	molybdopterin cofactor binding
NP165_RS13550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP165_RS13555	COG3447	MASE1 domain protein
NP165_RS13555	COG5001	Diguanylate cyclase
NP165_RS13555	COG5002	protein histidine kinase activity
NP165_RS13560	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP165_RS13570	COG1984	allophanate hydrolase subunit 2
NP165_RS13575	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NP165_RS13575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP165_RS13580	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NP165_RS13585	COG4181	ATPase activity
NP165_RS13595	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP165_RS13600	COG5001	Diguanylate cyclase
NP165_RS13600	COG3300	MHYT domain
NP165_RS13630	COG0210	DNA helicase
NP165_RS13635	COG1289	transmembrane transporter activity
NP165_RS13655	COG1879	ABC-type sugar transport system periplasmic component
NP165_RS13660	COG2827	Endonuclease containing a URI domain
NP165_RS13665	COG3132	Protein of unknown function, DUF480
NP165_RS13695	COG0545	Peptidyl-prolyl cis-trans isomerase
NP165_RS13705	COG0189	ligase activity
NP165_RS13705	COG4067	protein conserved in archaea
NP165_RS13710	COG1448	Aminotransferase
NP165_RS13715	COG0602	queuosine metabolic process
NP165_RS13720	COG1328	CTP reductase activity
NP165_RS13730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP165_RS13795	COG0583	DNA-binding transcription factor activity
NP165_RS13800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP165_RS13805	COG2814	Major facilitator Superfamily
NP165_RS13810	COG1794	racemase activity, acting on amino acids and derivatives
NP165_RS13825	COG0183	Belongs to the thiolase family
NP165_RS13855	COG0583	DNA-binding transcription factor activity
NP165_RS13860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NP165_RS13865	COG2855	membrane
NP165_RS13870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP165_RS13885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP165_RS13895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP165_RS13895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NP165_RS13905	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NP165_RS13915	COG0348	domain, Protein
NP165_RS13915	COG3901	Regulator of nitric oxide reductase transcription
NP165_RS13945	COG0583	DNA-binding transcription factor activity
NP165_RS13950	COG0435	Glutathione S-transferase
NP165_RS13955	COG2259	Doxx family
NP165_RS13960	COG1126	abc transporter atp-binding protein
NP165_RS13965	COG0765	amino acid transport
NP165_RS13970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP165_RS13985	COG1136	(ABC) transporter
NP165_RS13990	COG0577	efflux transmembrane transporter activity
NP165_RS13990	COG1136	(ABC) transporter
NP165_RS14005	COG1115	amino acid carrier protein
NP165_RS14050	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP165_RS14090	COG4191	Histidine kinase
NP165_RS14100	COG2271	Major facilitator Superfamily
NP165_RS14105	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NP165_RS14115	COG5002	protein histidine kinase activity
NP165_RS14115	COG2176	DNA-directed DNA polymerase activity
NP165_RS14120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP165_RS14125	COG1846	Transcriptional regulator
NP165_RS14150	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NP165_RS14160	COG0494	nUDIX hydrolase
NP165_RS14165	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
NP165_RS14185	COG1518	maintenance of DNA repeat elements
NP165_RS14190	COG1203	CRISPR-associated helicase, Cas3
NP165_RS14245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP165_RS14250	COG0835	chemotaxis
NP165_RS14250	COG0784	Response regulator, receiver
NP165_RS14255	COG3706	GGDEF domain
NP165_RS14270	COG1760	l-serine dehydratase
NP165_RS14275	COG0583	DNA-binding transcription factor activity
NP165_RS14280	COG3335	DDE superfamily endonuclease
NP165_RS14290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP165_RS14315	COG3842	ATPase activity
NP165_RS14320	COG1840	ABC-type Fe3 transport system, periplasmic component
NP165_RS14330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP165_RS14335	COG1011	Hydrolase
NP165_RS14350	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NP165_RS14355	COG1454	alcohol dehydrogenase
NP165_RS14380	COG3186	Phenylalanine-4-hydroxylase
NP165_RS14385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP165_RS14405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NP165_RS14415	COG0840	transmembrane signaling receptor activity
NP165_RS14420	COG1227	inorganic diphosphatase activity
NP165_RS14425	COG1120	ATPase activity
NP165_RS14430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP165_RS14435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP165_RS14455	COG1024	Enoyl-CoA hydratase
NP165_RS14460	COG1960	acyl-CoA dehydrogenase activity
NP165_RS14470	COG0183	Belongs to the thiolase family
NP165_RS14480	COG1960	acyl-CoA dehydrogenase activity
NP165_RS14485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP165_RS14495	COG4770	biotin carboxylase activity
NP165_RS14505	COG0798	PFAM Bile acid sodium symporter
NP165_RS14515	COG0318	PFAM AMP-dependent synthetase and ligase
NP165_RS14525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP165_RS14530	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP165_RS14530	COG0022	dehydrogenase e1 component
NP165_RS14535	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP165_RS14545	COG0574	Belongs to the PEP-utilizing enzyme family
NP165_RS14545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP165_RS14550	COG0543	2 iron, 2 sulfur cluster binding
NP165_RS14560	COG3383	formate dehydrogenase (NAD+) activity
NP165_RS14565	COG2116	formate transmembrane transporter activity
NP165_RS14570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP165_RS14640	COG1162	GTPase activity
NP165_RS14650	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP165_RS14670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP165_RS14675	COG2239	Acts as a magnesium transporter
NP165_RS14700	COG1278	Cold shock
NP165_RS14740	COG2207	Transcriptional regulator
NP165_RS14745	COG1621	beta-fructofuranosidase activity
NP165_RS14750	COG4172	Belongs to the ABC transporter superfamily
NP165_RS14755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP165_RS14760	COG0601	transmembrane transport
NP165_RS14765	COG0747	negative chemotaxis
NP165_RS14775	COG2211	Major facilitator Superfamily
NP165_RS14785	COG2169	Transcriptional regulator
NP165_RS14790	COG1609	Transcriptional regulator
NP165_RS14810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP165_RS14815	COG1979	alcohol dehydrogenase
NP165_RS14820	COG0656	L-ascorbic acid biosynthetic process
NP165_RS14830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP165_RS14850	COG0789	Transcriptional regulator
NP165_RS14855	COG4604	ABC transporter, ATP-binding protein
NP165_RS14860	COG4605	iron ion homeostasis
NP165_RS14865	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP165_RS14885	COG1464	Belongs to the NlpA lipoprotein family
NP165_RS14890	COG4172	Belongs to the ABC transporter superfamily
NP165_RS14895	COG4239	(ABC) transporter, permease
NP165_RS14900	COG4174	ABC transporter (Permease)
NP165_RS14905	COG4166	transmembrane transport
NP165_RS14940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP165_RS14945	COG1067	ATP-dependent peptidase activity
NP165_RS14955	COG0583	DNA-binding transcription factor activity
NP165_RS14960	COG1620	l-lactate permease
NP165_RS14965	COG1304	FMN binding
NP165_RS14970	COG0277	FAD linked oxidase domain protein
NP165_RS14975	COG0318	PFAM AMP-dependent synthetase and ligase
NP165_RS14985	COG3842	ATPase activity
NP165_RS14995	COG1175	transmembrane transport
NP165_RS15000	COG1653	transport
NP165_RS15005	COG0584	glycerophosphoryl diester phosphodiesterase
NP165_RS15030	COG0612	Peptidase, M16
NP165_RS15040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP165_RS15075	COG2204	response regulator
NP165_RS15090	COG0463	Glycosyl transferase, family 2
NP165_RS15090	COG1216	Glycosyl transferase, family 2
NP165_RS15100	COG1216	Glycosyl transferase, family 2
NP165_RS15115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP165_RS15145	COG1063	alcohol dehydrogenase
NP165_RS15150	COG0156	8-amino-7-oxononanoate synthase activity
NP165_RS15180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NP165_RS15185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NP165_RS15190	COG0363	glucosamine-6-phosphate deaminase activity
NP165_RS15195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP165_RS15225	COG3284	Transcriptional regulator
NP165_RS15255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP165_RS15285	COG3842	ATPase activity
NP165_RS15320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP165_RS15325	COG2197	response regulator
NP165_RS15350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP165_RS15355	COG5001	Diguanylate cyclase
NP165_RS15355	COG3300	MHYT domain
NP165_RS15380	COG0840	transmembrane signaling receptor activity
NP165_RS15390	COG1523	belongs to the glycosyl hydrolase 13 family
NP165_RS15400	COG1278	Cold shock
NP165_RS15405	COG3335	DDE superfamily endonuclease
NP165_RS15420	COG4628	conserved protein (DUF2132)
NP165_RS15425	COG0513	Belongs to the DEAD box helicase family
NP165_RS15430	COG3530	Putative quorum-sensing-regulated virulence factor
NP165_RS15440	COG1686	Belongs to the peptidase S11 family
NP165_RS15455	COG3036	rescue of stalled ribosome
NP165_RS15460	COG1278	Cold shock
NP165_RS15475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP165_RS15475	COG1017	nitric oxide dioxygenase activity
NP165_RS15480	COG3604	Transcriptional regulator
NP165_RS15495	COG0534	Mate efflux family protein
NP165_RS15500	COG0697	spore germination
NP165_RS15510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP165_RS15525	COG0583	DNA-binding transcription factor activity
NP165_RS15530	COG5001	Diguanylate cyclase
NP165_RS15545	COG3949	Membrane
NP165_RS15555	COG0840	transmembrane signaling receptor activity
NP165_RS15560	COG3302	dmso reductase anchor subunit
NP165_RS15565	COG0437	4 iron, 4 sulfur cluster binding
NP165_RS15570	COG0243	molybdopterin cofactor binding
NP165_RS15605	COG1609	Transcriptional regulator
NP165_RS15610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP165_RS15615	COG3265	gluconokinase activity
NP165_RS15620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NP165_RS15630	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NP165_RS15655	COG3123	guanosine phosphorylase activity
NP165_RS15665	COG0668	transmembrane transport
NP165_RS15675	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NP165_RS15680	COG4989	oxidoreductase activity
NP165_RS15685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NP165_RS15695	COG0109	protoheme IX farnesyltransferase activity
NP165_RS15730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP165_RS15740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP165_RS15750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP165_RS15755	COG4232	protein-disulfide reductase activity
NP165_RS15765	COG1280	lysine exporter protein (LysE YggA)
NP165_RS15795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NP165_RS15805	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NP165_RS15810	COG0513	Belongs to the DEAD box helicase family
NP165_RS15815	COG1609	Transcriptional regulator
NP165_RS15820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP165_RS15835	COG2197	response regulator
NP165_RS15850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP165_RS15860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP165_RS15885	COG0277	FAD linked oxidase domain protein
NP165_RS15895	COG0189	ligase activity
NP165_RS15900	COG3085	chromosome segregation
NP165_RS15905	COG0069	glutamate synthase activity
NP165_RS15930	COG3152	Membrane
NP165_RS15950	COG1120	ATPase activity
NP165_RS15955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP165_RS15970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP165_RS15980	COG3384	dioxygenase
NP165_RS15990	COG3639	organic phosphonate transmembrane transporter activity
NP165_RS15995	COG3639	organic phosphonate transmembrane transporter activity
NP165_RS16000	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NP165_RS16020	COG4191	Histidine kinase
NP165_RS16045	COG1234	tRNA 3'-trailer cleavage
NP165_RS16065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NP165_RS16070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP165_RS16090	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NP165_RS16095	COG0811	peptide transport
NP165_RS16100	COG0848	biopolymer transport protein
NP165_RS16105	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NP165_RS16115	COG3047	cAMP biosynthetic process
NP165_RS16120	COG0739	heme binding
NP165_RS16145	COG3314	Sporulation integral membrane protein YlbJ
NP165_RS16185	COG0438	transferase activity, transferring glycosyl groups
NP165_RS16190	COG1045	serine acetyltransferase
NP165_RS16200	COG1216	Glycosyl transferase, family 2
NP165_RS16215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NP165_RS16220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NP165_RS16240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP165_RS16245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP165_RS16250	COG0581	inorganic phosphate transmembrane transporter activity
NP165_RS16255	COG0573	inorganic phosphate transmembrane transporter activity
NP165_RS16270	COG0513	Belongs to the DEAD box helicase family
NP165_RS16280	COG1376	ErfK ybiS ycfS ynhG family protein
NP165_RS16280	COG1388	LysM domain
NP165_RS16285	COG0415	Belongs to the DNA photolyase family
NP165_RS16290	COG0789	Transcriptional regulator
NP165_RS16295	COG3272	Protein of unknown function (DUF1722)
NP165_RS16300	COG0813	purine-nucleoside phosphorylase activity
NP165_RS16325	COG3335	DDE superfamily endonuclease
NP165_RS16330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP165_RS16335	COG2313	pseudouridylate synthase activity
NP165_RS16340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP165_RS16350	COG1957	nucleoside hydrolase
NP165_RS16360	COG1566	PFAM secretion protein HlyD family protein
NP165_RS16370	COG0840	transmembrane signaling receptor activity
NP165_RS16375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP165_RS16405	COG0506	proline dehydrogenase activity
NP165_RS16405	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NP165_RS16405	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NP165_RS16415	COG0259	pyridoxamine-phosphate oxidase activity
NP165_RS16445	COG3033	Beta-eliminating lyase
NP165_RS16450	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NP165_RS16460	COG1999	signal sequence binding
NP165_RS16470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NP165_RS16480	COG0363	glucosamine-6-phosphate deaminase activity
NP165_RS16495	COG0561	phosphatase activity
NP165_RS16500	COG3385	transposase activity
NP165_RS16505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NP165_RS16510	COG1640	4-alpha-glucanotransferase
NP165_RS16515	COG0058	SHG alpha-glucan phosphorylase activity
NP165_RS16520	COG2909	trisaccharide binding
NP165_RS16545	COG1280	lysine exporter protein (LysE YggA)
NP165_RS16555	COG0443	Heat shock 70 kDa protein
NP165_RS16570	COG2885	chlorophyll binding
NP165_RS16585	COG1444	tRNA N-acetyltransferase activity
NP165_RS16610	COG4608	Belongs to the ABC transporter superfamily
NP165_RS16615	COG0444	Belongs to the ABC transporter superfamily
NP165_RS16640	COG0697	spore germination
NP165_RS16645	COG1846	Transcriptional regulator
NP165_RS16650	COG0589	response to stress
NP165_RS16675	COG0351	phosphomethylpyrimidine kinase
NP165_RS16700	COG0471	metal ion transport
NP165_RS16705	COG0010	Belongs to the arginase family
NP165_RS16710	COG1166	arginine decarboxylase activity
NP165_RS16730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP165_RS16740	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP165_RS16745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP165_RS16750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP165_RS16755	COG1671	Belongs to the UPF0178 family
NP165_RS16765	COG0243	molybdopterin cofactor binding
NP165_RS16770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP165_RS16770	COG1648	precorrin-2 dehydrogenase activity
NP165_RS16775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP165_RS16780	COG2146	nitrite reductase [NAD(P)H] activity
NP165_RS16785	COG2223	nitrite transmembrane transporter activity
NP165_RS16790	COG2815	serine threonine protein kinase
NP165_RS16790	COG0515	serine threonine protein kinase
NP165_RS16795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP165_RS16800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP165_RS16805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP165_RS16810	COG1120	ATPase activity
NP165_RS16830	COG2814	Major facilitator Superfamily
NP165_RS16835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP165_RS16860	COG1309	transcriptional regulator
NP165_RS16880	COG3383	formate dehydrogenase (NAD+) activity
NP165_RS16885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP165_RS16890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP165_RS16895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP165_RS16900	COG1120	ATPase activity
NP165_RS16920	COG1414	Transcriptional regulator
NP165_RS16925	COG0596	Alpha beta hydrolase
NP165_RS16930	COG0183	Belongs to the thiolase family
NP165_RS16935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP165_RS16940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP165_RS16950	COG4948	Mandelate Racemase Muconate Lactonizing
NP165_RS16960	COG3485	protocatechuate 3,4-dioxygenase
NP165_RS16985	COG2814	Major facilitator Superfamily
NP165_RS17000	COG3266	domain, Protein
NP165_RS17010	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP165_RS17025	COG1741	Belongs to the pirin family
NP165_RS17030	COG1132	(ABC) transporter
NP165_RS17045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP165_RS17045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP165_RS17050	COG0840	transmembrane signaling receptor activity
NP165_RS17055	COG0589	response to stress
NP165_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
NP165_RS17085	COG4772	TonB-dependent receptor
NP165_RS17095	COG1355	regulation of microtubule-based process
NP165_RS17105	COG3842	ATPase activity
NP165_RS17110	COG0546	phosphoglycolate phosphatase activity
NP165_RS17130	COG1175	transmembrane transport
NP165_RS17135	COG0583	DNA-binding transcription factor activity
NP165_RS17145	COG1335	isochorismatase
NP165_RS17155	COG0384	phenazine biosynthesis protein PhzF
NP165_RS17160	COG2113	Glycine betaine
NP165_RS17165	COG4176	ABC-type proline glycine betaine transport system permease component
NP165_RS17175	COG1309	transcriptional regulator
NP165_RS17180	COG1012	belongs to the aldehyde dehydrogenase family
NP165_RS17195	COG4176	ABC-type proline glycine betaine transport system permease component
NP165_RS17210	COG0456	acetyltransferase
NP165_RS17215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP165_RS17220	COG0662	Cupin 2, conserved barrel domain protein
NP165_RS17225	COG0527	aspartate kinase activity
NP165_RS17235	COG0786	glutamate:sodium symporter activity
NP165_RS17255	COG1247	-acetyltransferase
NP165_RS17265	COG3608	succinylglutamate desuccinylase aspartoacylase
NP165_RS17270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP165_RS17275	COG1151	hydroxylamine reductase activity
NP165_RS17280	COG3604	Transcriptional regulator
NP165_RS17290	COG2329	Antibiotic biosynthesis monooxygenase
NP165_RS17300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP165_RS17310	COG0583	DNA-binding transcription factor activity
NP165_RS17320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NP165_RS17325	COG1940	carbohydrate kinase activity
NP165_RS17330	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NP165_RS17335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP165_RS17340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP165_RS17345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NP165_RS17350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP165_RS17355	COG1737	Transcriptional regulator
NP165_RS17360	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
NP165_RS17370	COG4580	involved in the transport of maltose and maltodextrins
NP165_RS17380	COG3842	ATPase activity
NP165_RS17390	COG1175	transmembrane transport
NP165_RS17395	COG3833	ABC-type maltose transport systems, permease component
NP165_RS17425	COG2239	Acts as a magnesium transporter
NP165_RS17430	COG0531	amino acid
NP165_RS17435	COG1522	sequence-specific DNA binding
NP165_RS17450	COG0673	inositol 2-dehydrogenase activity
NP165_RS17455	COG1765	OsmC-like protein
NP165_RS17465	COG3034	peptidoglycan biosynthetic process
NP165_RS17470	COG5001	Diguanylate cyclase
NP165_RS17475	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NP165_RS17480	COG1263	PTS System
NP165_RS17480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP165_RS17480	COG2190	(PTS) system
NP165_RS17485	COG1737	Transcriptional regulator
NP165_RS17500	COG2304	oxidoreductase activity
NP165_RS17520	COG0714	Associated with various cellular activities
NP165_RS17555	COG0418	dihydroorotase activity
NP165_RS17560	COG0633	Ferredoxin
NP165_RS17560	COG3217	Mosc domain protein beta barrel domain protein
NP165_RS17560	COG0633	Ferredoxin
NP165_RS17560	COG3217	Mosc domain protein beta barrel domain protein
NP165_RS17565	COG0697	spore germination
NP165_RS17590	COG2855	membrane
NP165_RS17605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP165_RS17610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP165_RS17615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP165_RS17620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NP165_RS17620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP165_RS17630	COG1414	Transcriptional regulator
NP165_RS17635	COG0280	phosphate acetyltransferase
NP165_RS17640	COG0730	response to heat
NP165_RS17650	COG2354	Protein conserved in bacteria
NP165_RS17660	COG0366	Alpha amylase catalytic
NP165_RS17690	COG2201	protein-glutamate methylesterase activity
NP165_RS17700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NP165_RS17700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NP165_RS17705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP165_RS17715	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NP165_RS17720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NP165_RS17905	COG2329	Antibiotic biosynthesis monooxygenase
NP165_RS17910	COG0456	acetyltransferase
NP165_RS17945	COG0456	acetyltransferase
NP165_RS17965	COG2329	Antibiotic biosynthesis monooxygenase
NP165_RS18065	COG1403	HNH endonuclease
NP165_RS18080	COG0456	acetyltransferase
NP165_RS18090	COG0724	RNA recognition motif
NP165_RS18185	COG2026	Addiction module toxin, RelE StbE family
NP165_RS18205	COG0456	acetyltransferase
NP165_RS18255	COG2944	sequence-specific DNA binding
NP165_RS18260	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
NP165_RS18350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NP165_RS18350	COG0546	phosphoglycolate phosphatase activity
NP165_RS18375	COG0438	transferase activity, transferring glycosyl groups
NP165_RS18385	COG3273	potassium ion transport
NP165_RS18385	COG0471	metal ion transport
NP165_RS18400	COG0574	Belongs to the PEP-utilizing enzyme family
NP165_RS18400	COG3848	Pyruvate phosphate dikinase
NP165_RS18405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NP165_RS18410	COG1213	nucleotidyl transferase
NP165_RS18430	COG0438	transferase activity, transferring glycosyl groups
NP165_RS18440	COG0438	transferase activity, transferring glycosyl groups
NP165_RS18445	COG0367	asparagine synthase
NP165_RS18470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP165_RS18505	COG1696	Membrane protein involved in D-alanine export
NP165_RS18515	COG0393	Putative heavy-metal-binding
NP165_RS18555	COG1815	bacterial-type flagellum-dependent cell motility
NP165_RS18560	COG1558	bacterial-type flagellum-dependent cell motility
NP165_RS18570	COG1749	Flagellar hook protein flgE
NP165_RS18575	COG4787	bacterial-type flagellum-dependent cell motility
NP165_RS18580	COG4786	Flagellar basal body rod
NP165_RS18585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NP165_RS18590	COG1706	bacterial-type flagellum-dependent cell motility
NP165_RS18600	COG4786	Flagellar basal body rod
NP165_RS18600	COG1256	bacterial-type flagellum assembly
NP165_RS18620	COG1360	Flagellar Motor Protein
NP165_RS18625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP165_RS18630	COG1191	sigma factor activity
NP165_RS18635	COG1580	Controls the rotational direction of flagella during chemotaxis
NP165_RS18655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NP165_RS18660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP165_RS18675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP165_RS18685	COG1987	bacterial-type flagellum assembly
NP165_RS18715	COG1677	Flagellar hook-basal body complex protein FliE
NP165_RS18780	COG2995	paraquat-inducible protein a
NP165_RS18785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NP165_RS18785	COG3008	intermembrane lipid transfer
NP165_RS18820	COG1280	lysine exporter protein (LysE YggA)
NP165_RS18825	COG0454	-acetyltransferase
NP165_RS18830	COG0625	glutathione transferase activity
NP165_RS18835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP165_RS18840	COG2084	Dehydrogenase
NP165_RS18845	COG3097	Belongs to the UPF0267 family
NP165_RS18850	COG0513	Belongs to the DEAD box helicase family
NP165_RS18855	COG0564	pseudouridine synthase activity
NP165_RS18865	COG0583	DNA-binding transcription factor activity
NP165_RS18870	COG2375	cellular response to nickel ion
NP165_RS18890	COG0516	GMP reductase activity
NP165_RS18925	COG0577	efflux transmembrane transporter activity
NP165_RS18930	COG1136	(ABC) transporter
NP165_RS18940	COG3842	ATPase activity
NP165_RS18945	COG0583	DNA-binding transcription factor activity
NP165_RS18950	COG3624	Phosphonate C-P lyase system protein PhnG
NP165_RS18955	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
NP165_RS18960	COG3626	phosphonate metabolism
NP165_RS18965	COG3627	carbon phosphorus lyase activity
NP165_RS18970	COG4107	phosphonate C-P lyase system protein PhnK
NP165_RS18975	COG4778	phosphonate C-P lyase system protein PhnL
NP165_RS18980	COG3454	Phosphonate metabolism
NP165_RS18985	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
NP165_RS18990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NP165_RS18995	COG1840	ABC-type Fe3 transport system, periplasmic component
NP165_RS19025	COG2988	succinylglutamate desuccinylase activity
NP165_RS19030	COG1288	antiporter activity
NP165_RS19040	COG2731	YhcH YjgK YiaL family protein
NP165_RS19055	COG0800	Aldolase
NP165_RS19060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP165_RS19070	COG0246	Mannitol dehydrogenase
NP165_RS19080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP165_RS19090	COG2186	Transcriptional regulator
NP165_RS19100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP165_RS19110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP165_RS19120	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
NP165_RS19140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP165_RS19145	COG0662	Cupin 2, conserved barrel domain protein
NP165_RS19145	COG2207	Transcriptional regulator
NP165_RS19150	COG0697	spore germination
NP165_RS19160	COG1024	Enoyl-CoA hydratase
NP165_RS19165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP165_RS19170	COG1960	acyl-CoA dehydrogenase activity
NP165_RS19180	COG0183	Belongs to the thiolase family
NP165_RS19190	COG1960	acyl-CoA dehydrogenase activity
NP165_RS19195	COG1024	Enoyl-CoA hydratase
NP165_RS19200	COG1024	Enoyl-CoA hydratase
NP165_RS19210	COG1028	Short-chain dehydrogenase reductase Sdr
NP165_RS19220	COG2315	Protein conserved in bacteria
NP165_RS19245	COG0330	HflC and HflK could
NP165_RS19250	COG3264	Mechanosensitive ion channel
NP165_RS19250	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NP165_RS19255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP165_RS19295	COG3118	belongs to the thioredoxin family
NP165_RS19300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP165_RS19305	COG0420	3'-5' exonuclease activity
NP165_RS19310	COG0419	ATPase involved in DNA repair
NP165_RS19315	COG0784	Response regulator, receiver
NP165_RS19315	COG2205	protein histidine kinase activity
NP165_RS19325	COG0523	cobalamin synthesis protein
NP165_RS19350	COG1012	belongs to the aldehyde dehydrogenase family
NP165_RS19350	COG2030	dehydratase
NP165_RS19355	COG3396	Phenylacetate-CoA oxygenase
NP165_RS19360	COG3460	Phenylacetate-CoA oxygenase
NP165_RS19365	COG3396	Phenylacetate-CoA oxygenase
NP165_RS19370	COG2151	metal-sulfur cluster biosynthetic enzyme
NP165_RS19375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP165_RS19380	COG1024	Enoyl-CoA hydratase
NP165_RS19385	COG1024	Enoyl-CoA hydratase
NP165_RS19390	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP165_RS19395	COG2050	protein possibly involved in aromatic compounds catabolism
NP165_RS19400	COG0183	Belongs to the thiolase family
NP165_RS19405	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NP165_RS19410	COG3327	negative regulation of DNA-templated transcription, initiation
NP165_RS19420	COG0739	heme binding
NP165_RS19460	COG3829	transcription factor binding
NP165_RS19475	COG3501	Rhs element vgr protein
NP165_RS19500	COG0515	serine threonine protein kinase
NP165_RS19535	COG1522	sequence-specific DNA binding
NP165_RS19615	COG0583	DNA-binding transcription factor activity
NP165_RS19630	COG1012	belongs to the aldehyde dehydrogenase family
NP165_RS19640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP165_RS19645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP165_RS19665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP165_RS19670	COG2194	sulfuric ester hydrolase activity
NP165_RS19675	COG0642	Histidine kinase
NP165_RS19720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NP165_RS19735	COG0583	DNA-binding transcription factor activity
NP165_RS19750	COG1280	lysine exporter protein (LysE YggA)
NP165_RS19755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP165_RS19760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NP165_RS19770	COG0589	response to stress
NP165_RS19775	COG2897	thiosulfate sulfurtransferase activity
NP165_RS19785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP165_RS19790	COG0303	'Molybdopterin
NP165_RS19795	COG0302	gtp cyclohydrolase
NP165_RS19800	COG0513	Belongs to the DEAD box helicase family
NP165_RS19805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP165_RS19805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP165_RS19810	COG0814	amino acid
NP165_RS19820	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NP165_RS19825	COG0513	Belongs to the DEAD box helicase family
NP165_RS19845	COG0840	transmembrane signaling receptor activity
NP165_RS19850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP165_RS19855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP165_RS19870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP165_RS19880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP165_RS19890	COG1803	Methylglyoxal synthase
NP165_RS19895	COG1879	ABC-type sugar transport system periplasmic component
NP165_RS19900	COG0784	Response regulator, receiver
NP165_RS19900	COG2198	Histidine kinase
NP165_RS19900	COG2205	protein histidine kinase activity
NP165_RS19910	COG1979	alcohol dehydrogenase
NP165_RS19915	COG2207	Transcriptional regulator
NP165_RS19920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP165_RS19985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP165_RS19990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs