locus-tag	class	description
C1S73_RS00010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1S73_RS00035	COG1846	Transcriptional regulator
C1S73_RS00040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S73_RS00045	COG0840	transmembrane signaling receptor activity
C1S73_RS00065	COG1448	Aminotransferase
C1S73_RS00070	COG2770	Histidine kinase
C1S73_RS00070	COG3437	response regulator, receiver
C1S73_RS00075	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S73_RS00085	COG1609	Transcriptional regulator
C1S73_RS00105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S73_RS00120	COG0017	Asparaginyl-tRNA synthetase
C1S73_RS00130	COG0720	synthase
C1S73_RS00135	COG2197	response regulator
C1S73_RS00145	COG5001	Diguanylate cyclase
C1S73_RS00145	COG3300	MHYT domain
C1S73_RS00150	COG1760	l-serine dehydratase
C1S73_RS00155	COG0814	amino acid
C1S73_RS00160	COG0494	nUDIX hydrolase
C1S73_RS00170	COG0784	Response regulator, receiver
C1S73_RS00170	COG2205	protein histidine kinase activity
C1S73_RS00175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1S73_RS00190	COG3106	COG3106 Predicted ATPase
C1S73_RS00205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S73_RS00375	COG2801	Transposase and inactivated derivatives
C1S73_RS00415	COG2801	Transposase and inactivated derivatives
C1S73_RS00560	COG2026	Addiction module toxin, RelE StbE family
C1S73_RS00655	COG2801	Transposase and inactivated derivatives
C1S73_RS00685	COG2801	Transposase and inactivated derivatives
C1S73_RS00925	COG3340	Belongs to the peptidase S51 family
C1S73_RS00950	COG0456	acetyltransferase
C1S73_RS00955	COG0471	metal ion transport
C1S73_RS00960	COG4191	Histidine kinase
C1S73_RS00960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S73_RS00970	COG3300	MHYT domain
C1S73_RS00970	COG5001	Diguanylate cyclase
C1S73_RS00980	COG1280	lysine exporter protein (LysE YggA)
C1S73_RS00985	COG1328	CTP reductase activity
C1S73_RS00990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1S73_RS01005	COG0861	Integral membrane protein TerC family
C1S73_RS01015	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S73_RS01020	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS01025	COG3706	GGDEF domain
C1S73_RS01040	COG0814	amino acid
C1S73_RS01055	COG1120	ATPase activity
C1S73_RS01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1S73_RS01070	COG4774	siderophore transport
C1S73_RS01115	COG0644	oxidoreductase
C1S73_RS01125	COG1132	(ABC) transporter
C1S73_RS01130	COG1132	(ABC) transporter
C1S73_RS01135	COG2165	general secretion pathway protein
C1S73_RS01140	COG0583	DNA-binding transcription factor activity
C1S73_RS01170	COG0443	Heat shock 70 kDa protein
C1S73_RS01175	COG0443	Heat shock 70 kDa protein
C1S73_RS01215	COG3227	Zinc metalloprotease (Elastase)
C1S73_RS01225	COG0243	molybdopterin cofactor binding
C1S73_RS01230	COG0437	4 iron, 4 sulfur cluster binding
C1S73_RS01235	COG3302	dmso reductase anchor subunit
C1S73_RS01250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1S73_RS01255	COG1643	Atp-dependent helicase
C1S73_RS01280	COG3063	Type IV pilus biogenesis stability protein PilW
C1S73_RS01285	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1S73_RS01315	COG0531	amino acid
C1S73_RS01320	COG1280	lysine exporter protein (LysE YggA)
C1S73_RS01325	COG0583	DNA-binding transcription factor activity
C1S73_RS01330	COG1560	Kdo2-lipid A biosynthetic process
C1S73_RS01345	COG1846	Transcriptional regulator
C1S73_RS01360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1S73_RS01365	COG1280	lysine exporter protein (LysE YggA)
C1S73_RS01400	COG1115	amino acid carrier protein
C1S73_RS01430	COG1368	sulfuric ester hydrolase activity
C1S73_RS01435	COG0215	cysteine-tRNA ligase activity
C1S73_RS01445	COG2113	Glycine betaine
C1S73_RS01450	COG4176	ABC-type proline glycine betaine transport system permease component
C1S73_RS01460	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C1S73_RS01470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S73_RS01475	COG0456	acetyltransferase
C1S73_RS01480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1S73_RS01485	COG0662	Cupin 2, conserved barrel domain protein
C1S73_RS01490	COG0527	aspartate kinase activity
C1S73_RS01495	COG1858	cytochrome C peroxidase
C1S73_RS01500	COG1404	Belongs to the peptidase S8 family
C1S73_RS01550	COG2207	Transcriptional regulator
C1S73_RS01555	COG0697	spore germination
C1S73_RS01560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1S73_RS01565	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C1S73_RS01595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS01610	COG0431	NADPH-dependent FMN reductase
C1S73_RS01610	COG3976	FMN-binding domain protein
C1S73_RS01610	COG1053	succinate dehydrogenase
C1S73_RS01625	COG3290	protein histidine kinase activity
C1S73_RS01630	COG4565	transcriptional regulatory protein
C1S73_RS01635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1S73_RS01640	COG0363	glucosamine-6-phosphate deaminase activity
C1S73_RS01645	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1S73_RS01675	COG3284	Transcriptional regulator
C1S73_RS01680	COG1012	belongs to the aldehyde dehydrogenase family
C1S73_RS01690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S73_RS01695	COG2358	TRAP transporter, solute receptor (TAXI family
C1S73_RS01705	COG0814	amino acid
C1S73_RS01715	COG0730	response to heat
C1S73_RS01740	COG0456	acetyltransferase
C1S73_RS01750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S73_RS01755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S73_RS01865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1S73_RS01870	COG0372	Belongs to the citrate synthase family
C1S73_RS01880	COG2828	Protein conserved in bacteria
C1S73_RS01905	COG0561	phosphatase activity
C1S73_RS01910	COG0602	queuosine metabolic process
C1S73_RS01920	COG3706	GGDEF domain
C1S73_RS01970	COG1254	Belongs to the acylphosphatase family
C1S73_RS01975	COG2920	part of a sulfur-relay system
C1S73_RS01985	COG0670	Belongs to the BI1 family
C1S73_RS01990	COG1126	abc transporter atp-binding protein
C1S73_RS01995	COG0765	amino acid transport
C1S73_RS02000	COG4597	amino acid ABC transporter
C1S73_RS02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S73_RS02020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1S73_RS02045	COG3008	intermembrane lipid transfer
C1S73_RS02050	COG2995	paraquat-inducible protein a
C1S73_RS02055	COG1132	(ABC) transporter
C1S73_RS02060	COG1956	GAF domain-containing protein
C1S73_RS02065	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1S73_RS02080	COG0308	aminopeptidase N
C1S73_RS02090	COG2902	Dehydrogenase
C1S73_RS02115	COG0488	(ABC) transporter
C1S73_RS02130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1S73_RS02135	COG1067	ATP-dependent peptidase activity
C1S73_RS02140	COG3120	sequence-specific DNA binding
C1S73_RS02165	COG0784	Response regulator, receiver
C1S73_RS02165	COG2205	protein histidine kinase activity
C1S73_RS02180	COG3278	Belongs to the heme-copper respiratory oxidase family
C1S73_RS02195	COG2010	Cytochrome c
C1S73_RS02205	COG2217	Heavy metal translocating P-type atpase
C1S73_RS02220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S73_RS02225	COG0589	response to stress
C1S73_RS02250	COG3842	ATPase activity
C1S73_RS02260	COG1177	transmembrane transport
C1S73_RS02270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1S73_RS02275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1S73_RS02290	COG0437	4 iron, 4 sulfur cluster binding
C1S73_RS02295	COG0243	molybdopterin cofactor binding
C1S73_RS02295	COG3383	formate dehydrogenase (NAD+) activity
C1S73_RS02305	COG3381	protein complex oligomerization
C1S73_RS02325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1S73_RS02330	COG0488	(ABC) transporter
C1S73_RS02350	COG4191	Histidine kinase
C1S73_RS02355	COG2204	response regulator
C1S73_RS02365	COG4662	Binding-protein-dependent transport system inner membrane component
C1S73_RS02370	COG3842	ATPase activity
C1S73_RS02380	COG0303	'Molybdopterin
C1S73_RS02395	COG1940	carbohydrate kinase activity
C1S73_RS02400	COG3148	PFAM DTW domain containing protein
C1S73_RS02440	COG0840	transmembrane signaling receptor activity
C1S73_RS02445	COG0791	NLP P60 protein
C1S73_RS02455	COG3706	GGDEF domain
C1S73_RS02460	COG2201	protein-glutamate methylesterase activity
C1S73_RS02465	COG3001	Fructosamine kinase
C1S73_RS02475	COG0307	riboflavin synthase, alpha
C1S73_RS02480	COG0534	Mate efflux family protein
C1S73_RS02490	COG1793	dna ligase
C1S73_RS02500	COG2885	chlorophyll binding
C1S73_RS02510	COG0489	protein tyrosine kinase activity
C1S73_RS02520	COG2204	response regulator
C1S73_RS02530	COG0438	transferase activity, transferring glycosyl groups
C1S73_RS02560	COG0438	transferase activity, transferring glycosyl groups
C1S73_RS02565	COG1215	transferase activity, transferring glycosyl groups
C1S73_RS02570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1S73_RS02580	COG3064	Membrane
C1S73_RS02600	COG3300	MHYT domain
C1S73_RS02600	COG5001	Diguanylate cyclase
C1S73_RS02605	COG3437	response regulator, receiver
C1S73_RS02605	COG3850	Histidine kinase
C1S73_RS02605	COG4999	Histidine kinase
C1S73_RS02605	COG2205	protein histidine kinase activity
C1S73_RS02625	COG0110	maltose O-acetyltransferase activity
C1S73_RS02645	COG0693	protein deglycase activity
C1S73_RS02670	COG1846	Transcriptional regulator
C1S73_RS02680	COG2801	Transposase and inactivated derivatives
C1S73_RS02685	COG2963	transposase activity
C1S73_RS02695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1S73_RS02700	COG3247	response to pH
C1S73_RS02705	COG0668	transmembrane transport
C1S73_RS02715	COG1404	Belongs to the peptidase S8 family
C1S73_RS02730	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C1S73_RS02745	COG0745	RESPONSE REGULATOR receiver
C1S73_RS02820	COG0297	glycogen (starch) synthase activity
C1S73_RS02835	COG1454	alcohol dehydrogenase
C1S73_RS02840	COG0235	Class ii aldolase
C1S73_RS02845	COG4154	Belongs to the RbsD FucU family
C1S73_RS02850	COG1070	Carbohydrate kinase
C1S73_RS02855	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
C1S73_RS02860	COG0738	Major facilitator superfamily
C1S73_RS02865	COG1349	DNA-binding transcription factor activity
C1S73_RS02880	COG2197	response regulator
C1S73_RS02900	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C1S73_RS02910	COG3051	citrate lyase alpha subunit
C1S73_RS02915	COG2301	Belongs to the HpcH HpaI aldolase family
C1S73_RS02925	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C1S73_RS02935	COG3630	sodium ion export across plasma membrane
C1S73_RS02945	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C1S73_RS02955	COG4565	transcriptional regulatory protein
C1S73_RS03000	COG0625	glutathione transferase activity
C1S73_RS03010	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1S73_RS03025	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1S73_RS03055	COG0813	purine-nucleoside phosphorylase activity
C1S73_RS03075	COG1451	nucleotide metabolic process
C1S73_RS03080	COG5492	domain, Protein
C1S73_RS03080	COG4932	domain protein
C1S73_RS03105	COG0784	Response regulator, receiver
C1S73_RS03105	COG2205	protein histidine kinase activity
C1S73_RS03185	COG2963	transposase activity
C1S73_RS03190	COG2801	Transposase and inactivated derivatives
C1S73_RS03195	COG0583	DNA-binding transcription factor activity
C1S73_RS03225	COG4139	cobalamin transport
C1S73_RS03240	COG2062	phosphohistidine phosphatase, SixA
C1S73_RS03250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1S73_RS03260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1S73_RS03265	COG0702	epimerase
C1S73_RS03270	COG1823	symporter activity
C1S73_RS03280	COG2925	Exonuclease
C1S73_RS03290	COG1346	cytolysis
C1S73_RS03330	COG0072	phenylalanine-tRNA ligase activity
C1S73_RS03330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S73_RS03375	COG0251	oxidation-reduction process
C1S73_RS03390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1S73_RS03410	COG2188	Transcriptional regulator
C1S73_RS03420	COG0010	Belongs to the arginase family
C1S73_RS03430	COG2986	histidine ammonia-lyase
C1S73_RS03475	COG0247	lactate metabolic process
C1S73_RS03475	COG0277	FAD linked oxidase domain protein
C1S73_RS03530	COG1643	Atp-dependent helicase
C1S73_RS03540	COG2949	membrane
C1S73_RS03545	COG0471	metal ion transport
C1S73_RS03550	COG3706	GGDEF domain
C1S73_RS03570	COG0492	ferredoxin-NADP+ reductase activity
C1S73_RS03575	COG4988	ABC transporter
C1S73_RS03580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1S73_RS03590	COG2610	gluconate transmembrane transporter activity
C1S73_RS03595	COG0583	DNA-binding transcription factor activity
C1S73_RS03600	COG2200	EAL domain
C1S73_RS03630	COG5001	Diguanylate cyclase
C1S73_RS03640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1S73_RS03650	COG4191	Histidine kinase
C1S73_RS03650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S73_RS03665	COG3070	regulator of competence-specific genes
C1S73_RS03685	COG2431	L-lysine efflux transmembrane transporter activity
C1S73_RS03695	COG0076	glutamate decarboxylase activity
C1S73_RS03700	COG1737	Transcriptional regulator
C1S73_RS03710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1S73_RS03720	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1S73_RS03755	COG0534	Mate efflux family protein
C1S73_RS03760	COG0702	epimerase
C1S73_RS03765	COG4667	esterase of the alpha-beta hydrolase superfamily
C1S73_RS03775	COG2814	Major facilitator Superfamily
C1S73_RS03780	COG1187	pseudouridine synthase activity
C1S73_RS03785	COG1061	Type III restriction enzyme res subunit
C1S73_RS03790	COG3706	GGDEF domain
C1S73_RS03830	COG0454	-acetyltransferase
C1S73_RS03845	COG3313	Fe-S protein
C1S73_RS03855	COG0659	secondary active sulfate transmembrane transporter activity
C1S73_RS03885	COG0493	'glutamate synthase
C1S73_RS03895	COG0398	Pfam SNARE associated Golgi protein
C1S73_RS03900	COG4134	Bacterial extracellular solute-binding protein
C1S73_RS03905	COG4135	transport system, permease component
C1S73_RS03910	COG4136	ATPase activity
C1S73_RS03915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1S73_RS03920	COG3604	Transcriptional regulator
C1S73_RS03925	COG1151	hydroxylamine reductase activity
C1S73_RS03930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S73_RS03940	COG0564	pseudouridine synthase activity
C1S73_RS03950	COG0733	neurotransmitter:sodium symporter activity
C1S73_RS03960	COG0626	cystathionine gamma-synthase activity
C1S73_RS03965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1S73_RS03970	COG5380	lipid catabolic process
C1S73_RS03975	COG2818	Glycosylase
C1S73_RS04005	COG1842	Phage shock protein A
C1S73_RS04010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1S73_RS04020	COG4168	peptide transport system, permease
C1S73_RS04025	COG4171	peptide transport system, permease
C1S73_RS04035	COG4172	Belongs to the ABC transporter superfamily
C1S73_RS04045	COG1227	inorganic diphosphatase activity
C1S73_RS04050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1S73_RS04055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1S73_RS04060	COG1121	(ABC) transporter
C1S73_RS04075	COG0243	molybdopterin cofactor binding
C1S73_RS04080	COG3005	denitrification pathway
C1S73_RS04085	COG4459	periplasmic nitrate reductase
C1S73_RS04090	COG0390	transport system, permease component
C1S73_RS04100	COG2116	formate transmembrane transporter activity
C1S73_RS04110	COG2963	transposase activity
C1S73_RS04115	COG2801	Transposase and inactivated derivatives
C1S73_RS04135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1S73_RS04140	COG1435	thymidine kinase activity
C1S73_RS04145	COG0215	cysteine-tRNA ligase activity
C1S73_RS04150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1S73_RS04155	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1S73_RS04160	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1S73_RS04165	COG3012	SEC-C Motif Domain Protein
C1S73_RS04170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1S73_RS04170	COG0140	phosphoribosyl-ATP diphosphatase activity
C1S73_RS04185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1S73_RS04190	COG0131	Imidazoleglycerol-phosphate dehydratase
C1S73_RS04190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1S73_RS04200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1S73_RS04210	COG1757	Na H antiporter
C1S73_RS04220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S73_RS04240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1S73_RS04260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S73_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS04320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1S73_RS04340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1S73_RS04350	COG1674	ftsk spoiiie
C1S73_RS04360	COG0686	Belongs to the AlaDH PNT family
C1S73_RS04370	COG0583	DNA-binding transcription factor activity
C1S73_RS04405	COG3181	Tripartite tricarboxylate transporter family receptor
C1S73_RS04420	COG4934	collagen metabolic process
C1S73_RS04440	COG3568	Endonuclease Exonuclease Phosphatase
C1S73_RS04460	COG2165	general secretion pathway protein
C1S73_RS04470	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS04475	COG1917	Cupin 2, conserved barrel domain protein
C1S73_RS04490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S73_RS04495	COG1904	glucuronate isomerase
C1S73_RS04510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1S73_RS04520	COG0800	Aldolase
C1S73_RS04525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S73_RS04530	COG1917	Cupin 2, conserved barrel domain protein
C1S73_RS04560	COG2186	Transcriptional regulator
C1S73_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS04570	COG2186	Transcriptional regulator
C1S73_RS04575	COG0517	IMP dehydrogenase activity
C1S73_RS04580	COG2176	DNA-directed DNA polymerase activity
C1S73_RS04590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1S73_RS04605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S73_RS04635	COG1288	antiporter activity
C1S73_RS04645	COG2186	Transcriptional regulator
C1S73_RS04655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S73_RS04660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS04690	COG0747	negative chemotaxis
C1S73_RS04695	COG4608	Belongs to the ABC transporter superfamily
C1S73_RS04700	COG0444	Belongs to the ABC transporter superfamily
C1S73_RS04705	COG0534	Mate efflux family protein
C1S73_RS04720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S73_RS04725	COG0601	transmembrane transport
C1S73_RS04730	COG0747	negative chemotaxis
C1S73_RS04760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S73_RS04775	COG2824	Alkylphosphonate utilization operon protein PhnA
C1S73_RS04780	COG2723	6-phospho-beta-galactosidase activity
C1S73_RS04785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS04785	COG1263	PTS System
C1S73_RS04800	COG3119	arylsulfatase activity
C1S73_RS04840	COG0457	Tetratricopeptide repeat
C1S73_RS04910	COG4790	Type iii secretion
C1S73_RS04915	COG4794	Type iii secretion
C1S73_RS04920	COG4791	protein targeting
C1S73_RS04925	COG4792	protein secretion
C1S73_RS04940	COG3177	Filamentation induced by cAMP protein fic
C1S73_RS04970	COG4669	(LipO)protein
C1S73_RS05040	COG1078	dGTPase activity
C1S73_RS05080	COG0784	Response regulator, receiver
C1S73_RS05080	COG5002	protein histidine kinase activity
C1S73_RS05090	COG0754	glutathionylspermidine amidase activity
C1S73_RS05100	COG3766	membrane
C1S73_RS05115	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1S73_RS05120	COG2885	chlorophyll binding
C1S73_RS05125	COG0823	Involved in the tonB-independent uptake of proteins
C1S73_RS05140	COG0811	peptide transport
C1S73_RS05145	COG0824	Thioesterase
C1S73_RS05155	COG4890	Cyd operon protein YbgT
C1S73_RS05160	COG1294	oxidase, subunit
C1S73_RS05165	COG1271	oxidase subunit
C1S73_RS05175	COG0632	four-way junction helicase activity
C1S73_RS05180	COG0840	transmembrane signaling receptor activity
C1S73_RS05190	COG0217	transcriptional regulatory protein
C1S73_RS05200	COG1801	Protein of unknown function DUF72
C1S73_RS05220	COG4067	protein conserved in archaea
C1S73_RS05220	COG0189	ligase activity
C1S73_RS05245	COG0318	PFAM AMP-dependent synthetase and ligase
C1S73_RS05260	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1S73_RS05265	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1S73_RS05270	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
C1S73_RS05275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S73_RS05280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1S73_RS05285	COG0745	RESPONSE REGULATOR receiver
C1S73_RS05300	COG3070	regulator of competence-specific genes
C1S73_RS05320	COG0297	glycogen (starch) synthase activity
C1S73_RS05325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1S73_RS05330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1S73_RS05360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1S73_RS05365	COG0542	response to heat
C1S73_RS05375	COG1278	Cold shock
C1S73_RS05385	COG1187	pseudouridine synthase activity
C1S73_RS05390	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1S73_RS05400	COG1199	ATP-dependent helicase activity
C1S73_RS05405	COG0730	response to heat
C1S73_RS05410	COG3923	Primosomal replication protein n
C1S73_RS05420	COG0708	Exodeoxyribonuclease III
C1S73_RS05430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS05470	COG1882	Formate acetyltransferase
C1S73_RS05480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1S73_RS05500	COG2766	serine protein kinase
C1S73_RS05505	COG2718	Belongs to the UPF0229 family
C1S73_RS05530	COG1132	(ABC) transporter
C1S73_RS05535	COG0658	competence protein
C1S73_RS05535	COG2333	competence protein COMEC
C1S73_RS05545	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1S73_RS05550	COG1136	(ABC) transporter
C1S73_RS05555	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1S73_RS05565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1S73_RS05580	COG1252	NADH dehydrogenase
C1S73_RS05610	COG0537	adenosine 5'-monophosphoramidase activity
C1S73_RS05640	COG0516	GMP reductase activity
C1S73_RS05640	COG0517	IMP dehydrogenase activity
C1S73_RS05645	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C1S73_RS05650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1S73_RS05655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S73_RS05660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1S73_RS05670	COG2199	diguanylate cyclase activity
C1S73_RS05685	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C1S73_RS05690	COG1946	Acyl-CoA thioesterase
C1S73_RS05700	COG1522	sequence-specific DNA binding
C1S73_RS05720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S73_RS05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS05780	COG2855	membrane
C1S73_RS05790	COG0583	DNA-binding transcription factor activity
C1S73_RS05795	COG2190	(PTS) system
C1S73_RS05795	COG1263	PTS System
C1S73_RS05795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS05810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1S73_RS05815	COG0596	Alpha beta hydrolase
C1S73_RS05825	COG1169	isochorismate synthase
C1S73_RS05830	COG0436	Aminotransferase
C1S73_RS05835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1S73_RS05855	COG1555	photosystem II stabilization
C1S73_RS05860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S73_RS05865	COG0776	regulation of translation
C1S73_RS05870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1S73_RS05905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1S73_RS05910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1S73_RS05915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1S73_RS05935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1S73_RS05940	COG0569	domain protein
C1S73_RS05945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S73_RS05950	COG0513	Belongs to the DEAD box helicase family
C1S73_RS05955	COG1253	flavin adenine dinucleotide binding
C1S73_RS05960	COG4771	TonB-dependent receptor
C1S73_RS05975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1S73_RS05975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1S73_RS05980	COG3433	isochorismatase activity
C1S73_RS05980	COG1535	isochorismatase
C1S73_RS05985	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1S73_RS05990	COG1169	isochorismate synthase
C1S73_RS06000	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS06015	COG2226	methyltransferase
C1S73_RS06045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1S73_RS06050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1S73_RS06060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S73_RS06070	COG1216	Glycosyl transferase, family 2
C1S73_RS06075	COG2986	histidine ammonia-lyase
C1S73_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS06135	COG2852	Protein conserved in bacteria
C1S73_RS06140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1S73_RS06150	COG2951	lytic endotransglycosylase activity
C1S73_RS06165	COG2894	cell division
C1S73_RS06170	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1S73_RS06175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1S73_RS06180	COG0318	PFAM AMP-dependent synthetase and ligase
C1S73_RS06190	COG3065	identical protein binding
C1S73_RS06200	COG1214	PFAM Peptidase M22, glycoprotease
C1S73_RS06205	COG1199	ATP-dependent helicase activity
C1S73_RS06210	COG0788	formyltetrahydrofolate deformylase activity
C1S73_RS06215	COG3102	Protein conserved in bacteria
C1S73_RS06250	COG1918	ferrous iron import across plasma membrane
C1S73_RS06255	COG4977	sequence-specific DNA binding
C1S73_RS06260	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1S73_RS06265	COG1121	(ABC) transporter
C1S73_RS06270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1S73_RS06285	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1S73_RS06290	COG0567	Dehydrogenase, E1 component
C1S73_RS06300	COG1053	succinate dehydrogenase
C1S73_RS06305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1S73_RS06320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1S73_RS06330	COG0033	Phosphoglucomutase
C1S73_RS06335	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1S73_RS06340	COG0596	Alpha beta hydrolase
C1S73_RS06350	COG0716	FMN binding
C1S73_RS06360	COG0735	belongs to the Fur family
C1S73_RS06365	COG2165	general secretion pathway protein
C1S73_RS06375	COG2190	(PTS) system
C1S73_RS06375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS06375	COG1263	PTS System
C1S73_RS06385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1S73_RS06390	COG1846	Transcriptional regulator
C1S73_RS06390	COG1940	carbohydrate kinase activity
C1S73_RS06395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1S73_RS06395	COG4651	solute:proton antiporter activity
C1S73_RS06400	COG0367	asparagine synthase
C1S73_RS06405	COG0250	Participates in transcription elongation, termination and antitermination
C1S73_RS06410	COG3104	oligopeptide transport
C1S73_RS06415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1S73_RS06430	COG3710	Transcriptional regulator
C1S73_RS06450	COG0622	Phosphoesterase
C1S73_RS06480	COG1090	epimerase
C1S73_RS06485	COG0300	oxidoreductase activity
C1S73_RS06495	COG3118	belongs to the thioredoxin family
C1S73_RS06500	COG3118	belongs to the thioredoxin family
C1S73_RS06500	COG0457	Tetratricopeptide repeat
C1S73_RS06505	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C1S73_RS06510	COG1215	transferase activity, transferring glycosyl groups
C1S73_RS06515	COG1215	transferase activity, transferring glycosyl groups
C1S73_RS06535	COG2194	sulfuric ester hydrolase activity
C1S73_RS06540	COG0330	HflC and HflK could
C1S73_RS06570	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C1S73_RS06575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1S73_RS06585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS06590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1S73_RS06595	COG2190	(PTS) system
C1S73_RS06600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S73_RS06605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S73_RS06610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S73_RS06625	COG3951	Flagellar rod assembly protein muramidase FlgJ
C1S73_RS06625	COG1705	Flagellar rod assembly protein muramidase FlgJ
C1S73_RS06630	COG1706	bacterial-type flagellum-dependent cell motility
C1S73_RS06635	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1S73_RS06645	COG4787	bacterial-type flagellum-dependent cell motility
C1S73_RS06650	COG1749	Flagellar hook protein flgE
C1S73_RS06660	COG1558	bacterial-type flagellum-dependent cell motility
C1S73_RS06665	COG1815	bacterial-type flagellum-dependent cell motility
C1S73_RS06670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1S73_RS06675	COG0784	Response regulator, receiver
C1S73_RS06675	COG0835	chemotaxis
C1S73_RS06730	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1S73_RS06745	COG2608	mercury ion transmembrane transporter activity
C1S73_RS06745	COG2217	Heavy metal translocating P-type atpase
C1S73_RS06790	COG1187	pseudouridine synthase activity
C1S73_RS06795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1S73_RS06800	COG0737	Belongs to the 5'-nucleotidase family
C1S73_RS06810	COG2912	Transglutaminase-like superfamily
C1S73_RS06815	COG3094	Invasion gene expression up-regulator, SirB
C1S73_RS06820	COG2890	protein-(glutamine-N5) methyltransferase activity
C1S73_RS06845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1S73_RS06965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S73_RS06980	COG1702	phosphate starvation-inducible protein PhoH
C1S73_RS06990	COG4535	Mg2 and Co2 transporter CorC
C1S73_RS06995	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1S73_RS07000	COG2888	peptidyl-tyrosine sulfation
C1S73_RS07005	COG0495	leucyl-tRNA aminoacylation
C1S73_RS07010	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C1S73_RS07015	COG1466	dna polymerase III delta subunit
C1S73_RS07020	COG0799	negative regulation of ribosome biogenesis
C1S73_RS07025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1S73_RS07030	COG0768	penicillin binding
C1S73_RS07035	COG0772	Belongs to the SEDS family
C1S73_RS07040	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1S73_RS07045	COG1686	Belongs to the peptidase S11 family
C1S73_RS07065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1S73_RS07070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C1S73_RS07085	COG0366	Alpha amylase catalytic
C1S73_RS07090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS07090	COG1263	PTS System
C1S73_RS07100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1S73_RS07105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1S73_RS07110	COG2011	ABC-type metal ion transport system permease component
C1S73_RS07115	COG1464	Belongs to the NlpA lipoprotein family
C1S73_RS07125	COG0737	Belongs to the 5'-nucleotidase family
C1S73_RS07130	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C1S73_RS07155	COG1611	Belongs to the LOG family
C1S73_RS07170	COG2363	Small membrane protein
C1S73_RS07180	COG0583	DNA-binding transcription factor activity
C1S73_RS07195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1S73_RS07205	COG0142	geranyltranstransferase activity
C1S73_RS07215	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1S73_RS07220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1S73_RS07245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S73_RS07245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S73_RS07250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1S73_RS07255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1S73_RS07270	COG1073	alpha beta
C1S73_RS07280	COG2252	PERMEase
C1S73_RS07285	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1S73_RS07315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1S73_RS07315	COG0047	phosphoribosylformylglycinamidine synthase activity
C1S73_RS07340	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1S73_RS07380	COG1301	dicarboxylic acid transport
C1S73_RS07400	COG0497	DNA recombination
C1S73_RS07410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S73_RS07420	COG2914	Belongs to the UPF0125 (RnfH) family
C1S73_RS07425	COG2867	negative regulation of translational initiation
C1S73_RS07440	COG0583	DNA-binding transcription factor activity
C1S73_RS07445	COG1289	transmembrane transporter activity
C1S73_RS07465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1S73_RS07485	COG0719	Fe-S assembly protein
C1S73_RS07490	COG0396	ATPase activity
C1S73_RS07495	COG0719	Fe-S assembly protein
C1S73_RS07500	COG0316	Belongs to the HesB IscA family
C1S73_RS07510	COG2873	o-acetylhomoserine
C1S73_RS07525	COG0583	DNA-binding transcription factor activity
C1S73_RS07535	COG1115	amino acid carrier protein
C1S73_RS07540	COG1584	GPR1 FUN34 yaaH family protein
C1S73_RS07550	COG1757	Na H antiporter
C1S73_RS07560	COG0516	GMP reductase activity
C1S73_RS07560	COG0517	IMP dehydrogenase activity
C1S73_RS07575	COG2203	Gaf domain
C1S73_RS07575	COG2199	diguanylate cyclase activity
C1S73_RS07590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S73_RS07595	COG2976	Protein conserved in bacteria
C1S73_RS07630	COG2975	iron-sulfur cluster assembly
C1S73_RS07635	COG0633	Ferredoxin
C1S73_RS07650	COG0316	Belongs to the HesB IscA family
C1S73_RS07655	COG0822	iron-sulfur transferase activity
C1S73_RS07670	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1S73_RS07675	COG0483	inositol monophosphate 1-phosphatase activity
C1S73_RS07690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S73_RS07695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S73_RS07700	COG1862	Preprotein translocase
C1S73_RS07705	COG0343	queuine tRNA-ribosyltransferase activity
C1S73_RS07710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1S73_RS07725	COG0517	IMP dehydrogenase activity
C1S73_RS07735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1S73_RS07740	COG0583	DNA-binding transcription factor activity
C1S73_RS07745	COG0450	alkyl hydroperoxide reductase
C1S73_RS07775	COG0704	Plays a role in the regulation of phosphate uptake
C1S73_RS07780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1S73_RS07785	COG0581	inorganic phosphate transmembrane transporter activity
C1S73_RS07790	COG0573	inorganic phosphate transmembrane transporter activity
C1S73_RS07795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1S73_RS07800	COG0248	Ppx GppA phosphatase
C1S73_RS07810	COG5002	protein histidine kinase activity
C1S73_RS07815	COG0745	RESPONSE REGULATOR receiver
C1S73_RS07825	COG0826	peptidase U32
C1S73_RS07830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1S73_RS07840	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C1S73_RS07890	COG0542	response to heat
C1S73_RS07895	COG1496	oxidoreductase activity
C1S73_RS07900	COG0564	pseudouridine synthase activity
C1S73_RS07905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S73_RS07910	COG0741	lytic transglycosylase activity
C1S73_RS07915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1S73_RS07920	COG1605	Chorismate mutase
C1S73_RS07920	COG0077	Prephenate dehydratase
C1S73_RS07925	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C1S73_RS07940	COG0488	(ABC) transporter
C1S73_RS07950	COG0739	heme binding
C1S73_RS07955	COG1605	Chorismate mutase
C1S73_RS07955	COG0287	Prephenate dehydrogenase
C1S73_RS07960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1S73_RS07970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1S73_RS07990	COG1966	Carbon starvation protein
C1S73_RS07995	COG3275	phosphorelay sensor kinase activity
C1S73_RS08000	COG3279	Response regulator of the LytR AlgR family
C1S73_RS08005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1S73_RS08010	COG1047	Peptidyl-prolyl cis-trans
C1S73_RS08025	COG0196	riboflavin kinase activity
C1S73_RS08030	COG0728	peptidoglycan biosynthetic process
C1S73_RS08035	COG0268	Binds directly to 16S ribosomal RNA
C1S73_RS08040	COG0640	Transcriptional regulator
C1S73_RS08045	COG0583	DNA-binding transcription factor activity
C1S73_RS08050	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1S73_RS08065	COG0730	response to heat
C1S73_RS08070	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C1S73_RS08095	COG0667	Aldo Keto reductase
C1S73_RS08120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1S73_RS08125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1S73_RS08130	COG4974	Belongs to the 'phage' integrase family
C1S73_RS08135	COG0716	FMN binding
C1S73_RS08145	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1S73_RS08150	COG0513	Belongs to the DEAD box helicase family
C1S73_RS08160	COG3022	response to hydroperoxide
C1S73_RS08165	COG1115	amino acid carrier protein
C1S73_RS08205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1S73_RS08210	COG0083	homoserine kinase activity
C1S73_RS08225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1S73_RS08240	COG0745	RESPONSE REGULATOR receiver
C1S73_RS08250	COG0784	Response regulator, receiver
C1S73_RS08250	COG2198	Histidine kinase
C1S73_RS08250	COG5002	protein histidine kinase activity
C1S73_RS08255	COG2203	Gaf domain
C1S73_RS08255	COG4251	negative regulation of phosphorylation
C1S73_RS08255	COG3706	GGDEF domain
C1S73_RS08255	COG5001	Diguanylate cyclase
C1S73_RS08260	COG1242	4 iron, 4 sulfur cluster binding
C1S73_RS08265	COG0067	glutamate synthase
C1S73_RS08265	COG0069	glutamate synthase activity
C1S73_RS08265	COG0070	glutamate synthase
C1S73_RS08275	COG0069	glutamate synthase activity
C1S73_RS08275	COG0067	glutamate synthase
C1S73_RS08275	COG0070	glutamate synthase
C1S73_RS08280	COG0493	'glutamate synthase
C1S73_RS08305	COG2860	membrane
C1S73_RS08310	COG0583	DNA-binding transcription factor activity
C1S73_RS08315	COG0730	response to heat
C1S73_RS08330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1S73_RS08335	COG0505	Belongs to the CarA family
C1S73_RS08345	COG0494	nUDIX hydrolase
C1S73_RS08360	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1S73_RS08365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1S73_RS08370	COG0849	cell division
C1S73_RS08375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1S73_RS08390	COG0772	Belongs to the SEDS family
C1S73_RS08405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1S73_RS08410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1S73_RS08415	COG0768	penicillin binding
C1S73_RS08420	COG3116	cell division
C1S73_RS08440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1S73_RS08455	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1S73_RS08465	COG2969	positive regulation of protein catabolic process
C1S73_RS08470	COG0625	glutathione transferase activity
C1S73_RS08475	COG2857	Cytochrome c1
C1S73_RS08480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1S73_RS08485	COG0723	plastoquinol--plastocyanin reductase activity
C1S73_RS08490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1S73_RS08505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1S73_RS08515	COG3105	Protein conserved in bacteria
C1S73_RS08525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1S73_RS08540	COG3150	esterase
C1S73_RS08550	COG3151	Protein conserved in bacteria
C1S73_RS08555	COG0494	nUDIX hydrolase
C1S73_RS08560	COG1538	Outer membrane efflux protein
C1S73_RS08570	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1S73_RS08580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1S73_RS08585	COG3025	triphosphatase activity
C1S73_RS08590	COG1392	Phosphate transport regulator
C1S73_RS08595	COG0306	phosphate transporter
C1S73_RS08600	COG4991	sh3 domain protein
C1S73_RS08605	COG0405	Gamma-glutamyltransferase
C1S73_RS08615	COG3267	Type II secretory pathway component ExeA
C1S73_RS08615	COG3409	Peptidoglycan-binding domain 1 protein
C1S73_RS08630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1S73_RS08635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1S73_RS08645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S73_RS08650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1S73_RS08655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1S73_RS08660	COG1610	YqeY-like protein
C1S73_RS08665	COG0358	DNA primase activity
C1S73_RS08700	COG2213	PTS system mannitol-specific
C1S73_RS08700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS08710	COG3722	fumarate hydratase activity
C1S73_RS08715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1S73_RS08720	COG5002	protein histidine kinase activity
C1S73_RS08740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1S73_RS08745	COG1349	DNA-binding transcription factor activity
C1S73_RS08750	COG0469	pyruvate kinase activity
C1S73_RS08760	COG3706	GGDEF domain
C1S73_RS08765	COG0440	acetolactate synthase activity
C1S73_RS08770	COG0028	Belongs to the TPP enzyme family
C1S73_RS08775	COG1022	Amp-dependent synthetase and ligase
C1S73_RS08780	COG0583	DNA-binding transcription factor activity
C1S73_RS08810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S73_RS08815	COG0473	3-isopropylmalate dehydrogenase activity
C1S73_RS08835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1S73_RS08840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1S73_RS08845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S73_RS08850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1S73_RS08860	COG2967	ApaG domain
C1S73_RS08875	COG3610	response to peptide
C1S73_RS08880	COG2966	Psort location CytoplasmicMembrane, score
C1S73_RS08895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1S73_RS08900	COG0142	geranyltranstransferase activity
C1S73_RS08925	COG2358	TRAP transporter, solute receptor (TAXI family
C1S73_RS08940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1S73_RS08945	COG1178	ABC-type Fe3 transport system permease component
C1S73_RS08950	COG4143	(ABC) transporter
C1S73_RS08955	COG0163	prenyltransferase activity
C1S73_RS08960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1S73_RS08970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1S73_RS08985	COG2105	PFAM AIG2 family protein
C1S73_RS08990	COG2911	Protein conserved in bacteria
C1S73_RS08995	COG0729	surface antigen
C1S73_RS09000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S73_RS09010	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C1S73_RS09025	COG1136	(ABC) transporter
C1S73_RS09045	COG0529	Catalyzes the synthesis of activated sulfate
C1S73_RS09050	COG0471	metal ion transport
C1S73_RS09050	COG3273	potassium ion transport
C1S73_RS09060	COG0175	sulfate reduction
C1S73_RS09065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1S73_RS09065	COG1648	precorrin-2 dehydrogenase activity
C1S73_RS09070	COG0737	Belongs to the 5'-nucleotidase family
C1S73_RS09085	COG0513	Belongs to the DEAD box helicase family
C1S73_RS09090	COG2153	protein acetylation
C1S73_RS09105	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S73_RS09115	COG0203	ribosomal protein L17
C1S73_RS09120	COG0202	RNA polymerase activity
C1S73_RS09130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1S73_RS09135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1S73_RS09140	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1S73_RS09145	COG0201	protein transport
C1S73_RS09150	COG0200	Binds to the 23S rRNA
C1S73_RS09155	COG1841	ribosomal large subunit assembly
C1S73_RS09195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1S73_RS09225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1S73_RS09240	COG0088	Forms part of the polypeptide exit tunnel
C1S73_RS09260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1S73_RS09265	COG1609	Transcriptional regulator
C1S73_RS09285	COG1575	Belongs to the MenA family. Type 1 subfamily
C1S73_RS09290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1S73_RS09295	COG3074	FtsZ-dependent cytokinesis
C1S73_RS09305	COG1494	fructose-1,6-bisphosphatase
C1S73_RS09335	COG0149	triose-phosphate isomerase activity
C1S73_RS09340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1S73_RS09355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1S73_RS09365	COG1215	transferase activity, transferring glycosyl groups
C1S73_RS09445	COG1450	Type ii and iii secretion system protein
C1S73_RS09455	COG1459	type II secretion system
C1S73_RS09490	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S73_RS09495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S73_RS09510	COG1519	Transferase
C1S73_RS09530	COG2089	acid synthase
C1S73_RS09550	COG1083	cytidylyl-transferase
C1S73_RS09555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1S73_RS09560	COG1086	Polysaccharide biosynthesis protein
C1S73_RS09565	COG3642	lipopolysaccharide core region biosynthetic process
C1S73_RS09570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1S73_RS09575	COG0859	PFAM glycosyl transferase family 9
C1S73_RS09580	COG0463	Glycosyl transferase, family 2
C1S73_RS09585	COG0438	transferase activity, transferring glycosyl groups
C1S73_RS09615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1S73_RS09625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1S73_RS09635	COG1560	Kdo2-lipid A biosynthetic process
C1S73_RS09640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1S73_RS09645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1S73_RS09650	COG1561	YicC-like family, N-terminal region
C1S73_RS09660	COG3710	Transcriptional regulator
C1S73_RS09685	COG4608	Belongs to the ABC transporter superfamily
C1S73_RS09690	COG0444	Belongs to the ABC transporter superfamily
C1S73_RS09695	COG0747	negative chemotaxis
C1S73_RS09700	COG4239	(ABC) transporter, permease
C1S73_RS09705	COG4174	ABC transporter (Permease)
C1S73_RS09715	COG4206	TonB-dependent receptor
C1S73_RS09730	COG0811	peptide transport
C1S73_RS09735	COG0848	biopolymer transport protein
C1S73_RS09750	COG0194	GDP metabolic process
C1S73_RS09755	COG1758	RNA polymerase activity
C1S73_RS09760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1S73_RS09765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S73_RS09770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1S73_RS09780	COG2233	PERMEase
C1S73_RS09795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S73_RS09805	COG2183	response to ionizing radiation
C1S73_RS09820	COG1040	competence protein
C1S73_RS09830	COG0494	nUDIX hydrolase
C1S73_RS09835	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1S73_RS09845	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1S73_RS09850	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1S73_RS09855	COG3156	type II secretion system protein K
C1S73_RS09860	COG4795	General secretion pathway protein
C1S73_RS09865	COG2165	general secretion pathway protein
C1S73_RS09870	COG2165	general secretion pathway protein
C1S73_RS09875	COG2165	general secretion pathway protein
C1S73_RS09880	COG1459	type II secretion system
C1S73_RS09885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1S73_RS09895	COG3031	protein transport across the cell outer membrane
C1S73_RS09900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1S73_RS09920	COG0456	acetyltransferase
C1S73_RS09925	COG1490	D-aminoacyl-tRNA deacylase activity
C1S73_RS09945	COG1217	gtp-binding protein TYPA
C1S73_RS09955	COG0174	glutamine synthetase
C1S73_RS09965	COG3852	Histidine kinase
C1S73_RS09970	COG2204	response regulator
C1S73_RS09980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1S73_RS10015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1S73_RS10025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1S73_RS10025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1S73_RS10045	COG0084	hydrolase, TatD family'
C1S73_RS10050	COG0805	protein transport
C1S73_RS10055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1S73_RS10070	COG3165	ubiquinone biosynthetic process from chorismate
C1S73_RS10080	COG1322	Protein conserved in bacteria
C1S73_RS10115	COG2081	HI0933 family
C1S73_RS10125	COG1528	Iron-storage protein
C1S73_RS10130	COG0589	response to stress
C1S73_RS10150	COG5001	Diguanylate cyclase
C1S73_RS10150	COG5002	protein histidine kinase activity
C1S73_RS10155	COG1522	sequence-specific DNA binding
C1S73_RS10170	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1S73_RS10185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S73_RS10190	COG0800	Aldolase
C1S73_RS10195	COG2610	gluconate transmembrane transporter activity
C1S73_RS10200	COG3265	gluconokinase activity
C1S73_RS10205	COG0129	dihydroxy-acid dehydratase activity
C1S73_RS10215	COG2076	Multidrug Resistance protein
C1S73_RS10220	COG0583	DNA-binding transcription factor activity
C1S73_RS10225	COG1609	Transcriptional regulator
C1S73_RS10260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S73_RS10265	COG0601	transmembrane transport
C1S73_RS10270	COG4166	transmembrane transport
C1S73_RS10275	COG4172	Belongs to the ABC transporter superfamily
C1S73_RS10285	COG0546	phosphoglycolate phosphatase activity
C1S73_RS10325	COG1309	transcriptional regulator
C1S73_RS10330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS10335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S73_RS10345	COG2960	long-chain fatty acid transporting porin activity
C1S73_RS10405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1S73_RS10410	COG1739	Uncharacterized protein family UPF0029
C1S73_RS10420	COG0183	Belongs to the thiolase family
C1S73_RS10425	COG0604	alcohol dehydrogenase
C1S73_RS10440	COG0425	Belongs to the sulfur carrier protein TusA family
C1S73_RS10450	COG2119	membrane
C1S73_RS10465	COG0366	Alpha amylase catalytic
C1S73_RS10530	COG4964	Belongs to the GSP D family
C1S73_RS10550	COG3977	Valine--pyruvate aminotransferase
C1S73_RS10555	COG0071	Belongs to the small heat shock protein (HSP20) family
C1S73_RS10560	COG0187	DNA topoisomerase II activity
C1S73_RS10570	COG0592	DNA-directed DNA polymerase activity
C1S73_RS10595	COG1126	abc transporter atp-binding protein
C1S73_RS10625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1S73_RS10630	COG0445	tRNA wobble uridine modification
C1S73_RS10635	COG0357	Ribosomal RNA small subunit methyltransferase G
C1S73_RS10640	COG1192	Involved in chromosome partitioning
C1S73_RS10645	COG1475	DNA binding
C1S73_RS10650	COG3312	ion transport
C1S73_RS10680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1S73_RS10690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1S73_RS10700	COG0765	amino acid transport
C1S73_RS10710	COG2814	Major facilitator Superfamily
C1S73_RS10715	COG0583	DNA-binding transcription factor activity
C1S73_RS10720	COG3706	GGDEF domain
C1S73_RS10735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1S73_RS10740	COG3978	acetolactate synthase activity
C1S73_RS10750	COG0606	chelatase, subunit chli
C1S73_RS10760	COG0204	Acyl-transferase
C1S73_RS10765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1S73_RS10770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1S73_RS10780	COG3084	Protein conserved in bacteria
C1S73_RS10790	COG4326	sporulation control protein
C1S73_RS10795	COG1272	protein, Hemolysin III
C1S73_RS10805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1S73_RS10810	COG0569	domain protein
C1S73_RS10815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1S73_RS10815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1S73_RS10825	COG0242	peptide deformylase activity
C1S73_RS10835	COG0758	DNA mediated transformation
C1S73_RS10845	COG0551	DNA topoisomerase type I activity
C1S73_RS10850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1S73_RS10855	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1S73_RS10880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1S73_RS10925	COG2132	Multicopper oxidase
C1S73_RS10945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1S73_RS10950	COG2104	thiamine diphosphate biosynthetic process
C1S73_RS10965	COG0006	proline dipeptidase activity
C1S73_RS10965	COG0006	proline dipeptidase activity
C1S73_RS10975	COG2814	Major facilitator Superfamily
C1S73_RS10995	COG3220	belongs to the UPF0276 family
C1S73_RS11005	COG0210	DNA helicase
C1S73_RS11015	COG0405	Gamma-glutamyltransferase
C1S73_RS11020	COG1280	lysine exporter protein (LysE YggA)
C1S73_RS11030	COG2962	Rard protein
C1S73_RS11035	COG0514	ATP-dependent DNA helicase (RecQ)
C1S73_RS11050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1S73_RS11065	COG3118	belongs to the thioredoxin family
C1S73_RS11080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1S73_RS11085	COG0633	Ferredoxin
C1S73_RS11130	COG3071	HemY protein
C1S73_RS11135	COG2959	enzyme of heme biosynthesis
C1S73_RS11140	COG1587	Uroporphyrinogen-III synthase
C1S73_RS11150	COG3072	Adenylate cyclase
C1S73_RS11165	COG0019	diaminopimelate decarboxylase activity
C1S73_RS11185	COG1011	Hydrolase
C1S73_RS11190	COG2199	diguanylate cyclase activity
C1S73_RS11190	COG3287	FIST C domain
C1S73_RS11190	COG2200	EAL domain
C1S73_RS11195	COG3148	PFAM DTW domain containing protein
C1S73_RS11210	COG0561	phosphatase activity
C1S73_RS11215	COG2267	carboxylic ester hydrolase activity
C1S73_RS11220	COG1280	lysine exporter protein (LysE YggA)
C1S73_RS11225	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1S73_RS11230	COG0640	Transcriptional regulator
C1S73_RS11235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1S73_RS11285	COG2095	MarC family integral membrane protein
C1S73_RS11295	COG0742	ribosomal rna small subunit methyltransferase
C1S73_RS11300	COG0552	protein localization to endoplasmic reticulum
C1S73_RS11300	COG0552	protein localization to endoplasmic reticulum
C1S73_RS11305	COG2884	Cell division ATP-binding protein ftsE
C1S73_RS11310	COG2177	Part of the ABC transporter FtsEX involved in
C1S73_RS11335	COG1580	Controls the rotational direction of flagella during chemotaxis
C1S73_RS11340	COG3161	chorismate lyase activity
C1S73_RS11350	COG2937	Belongs to the GPAT DAPAT family
C1S73_RS11370	COG0534	Mate efflux family protein
C1S73_RS11375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S73_RS11380	COG1309	transcriptional regulator
C1S73_RS11445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S73_RS11455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1S73_RS11505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1S73_RS11510	COG0250	Participates in transcription elongation, termination and antitermination
C1S73_RS11515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1S73_RS11520	COG0081	regulation of translation
C1S73_RS11525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1S73_RS11545	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C1S73_RS11550	COG2816	NAD+ diphosphatase activity
C1S73_RS11560	COG1573	uracil-dna glycosylase
C1S73_RS11570	COG3068	Protein conserved in bacteria
C1S73_RS11575	COG1253	flavin adenine dinucleotide binding
C1S73_RS11590	COG0151	Belongs to the GarS family
C1S73_RS11595	COG0138	bifunctional purine biosynthesis protein purh
C1S73_RS11605	COG0789	Transcriptional regulator
C1S73_RS11610	COG3710	Transcriptional regulator
C1S73_RS11620	COG0531	amino acid
C1S73_RS11625	COG1982	Orn Lys Arg decarboxylase major
C1S73_RS11710	COG2199	diguanylate cyclase activity
C1S73_RS11715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1S73_RS11720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S73_RS11735	COG0439	Biotin carboxylase
C1S73_RS11740	COG0511	ligase activity, forming carbon-carbon bonds
C1S73_RS11745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1S73_RS11750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S73_RS11765	COG2814	Major facilitator Superfamily
C1S73_RS11770	COG0784	Response regulator, receiver
C1S73_RS11770	COG2198	Histidine kinase
C1S73_RS11770	COG2205	protein histidine kinase activity
C1S73_RS11790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S73_RS11800	COG2095	MarC family integral membrane protein
C1S73_RS11810	COG4232	protein-disulfide reductase activity
C1S73_RS11815	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1S73_RS11820	COG1027	Aspartate ammonia-lyase
C1S73_RS11825	COG3030	protein affecting phage T7 exclusion by the F plasmid
C1S73_RS11830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1S73_RS11840	COG2205	protein histidine kinase activity
C1S73_RS11845	COG0745	RESPONSE REGULATOR receiver
C1S73_RS11850	COG3678	ATP-independent chaperone mediated protein folding
C1S73_RS11855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1S73_RS11875	COG0459	protein refolding
C1S73_RS11885	COG1285	pathogenesis
C1S73_RS11890	COG1509	lysine 2,3-aminomutase activity
C1S73_RS11915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1S73_RS11920	COG1053	succinate dehydrogenase
C1S73_RS11945	COG4942	peptidase
C1S73_RS11950	COG1045	serine acetyltransferase
C1S73_RS11965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1S73_RS11970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1S73_RS11980	COG0840	transmembrane signaling receptor activity
C1S73_RS11985	COG0471	metal ion transport
C1S73_RS12000	COG1162	GTPase activity
C1S73_RS12080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1S73_RS12085	COG0802	atpase or kinase
C1S73_RS12090	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1S73_RS12095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1S73_RS12110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1S73_RS12115	COG0330	HflC and HflK could
C1S73_RS12120	COG0330	HflC and HflK could
C1S73_RS12125	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1S73_RS12130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1S73_RS12140	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1S73_RS12145	COG1017	nitric oxide dioxygenase activity
C1S73_RS12145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S73_RS12155	COG0557	exoribonuclease II activity
C1S73_RS12160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S73_RS12165	COG0546	phosphoglycolate phosphatase activity
C1S73_RS12190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1S73_RS12210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S73_RS12215	COG3954	Phosphoribulokinase
C1S73_RS12225	COG0429	hydrolase of the alpha beta-hydrolase fold
C1S73_RS12235	COG0488	(ABC) transporter
C1S73_RS12245	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1S73_RS12260	COG1047	Peptidyl-prolyl cis-trans
C1S73_RS12270	COG1446	asparaginase
C1S73_RS12285	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S73_RS12290	COG2964	Protein conserved in bacteria
C1S73_RS12295	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1S73_RS12300	COG2923	Belongs to the DsrF TusC family
C1S73_RS12305	COG2168	tRNA wobble position uridine thiolation
C1S73_RS12320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S73_RS12330	COG2906	2 iron, 2 sulfur cluster binding
C1S73_RS12340	COG0281	malic enzyme
C1S73_RS12350	COG0626	cystathionine gamma-synthase activity
C1S73_RS12355	COG0460	homoserine dehydrogenase
C1S73_RS12355	COG0527	aspartate kinase activity
C1S73_RS12360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1S73_RS12370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1S73_RS12380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1S73_RS12395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1S73_RS12395	COG0165	Argininosuccinate lyase
C1S73_RS12410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S73_RS12415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1S73_RS12415	COG0678	peroxiredoxin activity
C1S73_RS12425	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1S73_RS12470	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C1S73_RS12475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1S73_RS12485	COG2965	DNA replication, synthesis of RNA primer
C1S73_RS12510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1S73_RS12520	COG0432	Pfam Uncharacterised protein family UPF0047
C1S73_RS12535	COG0735	belongs to the Fur family
C1S73_RS12540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S73_RS12560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1S73_RS12635	COG0646	methionine synthase
C1S73_RS12635	COG1410	methionine synthase
C1S73_RS12640	COG0527	aspartate kinase activity
C1S73_RS12650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1S73_RS12660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1S73_RS12675	COG0629	single-stranded DNA binding
C1S73_RS12680	COG2199	diguanylate cyclase activity
C1S73_RS12680	COG2200	EAL domain
C1S73_RS12705	COG3267	Type II secretory pathway component ExeA
C1S73_RS12705	COG3409	Peptidoglycan-binding domain 1 protein
C1S73_RS12715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1S73_RS12720	COG1459	type II secretion system
C1S73_RS12730	COG2165	general secretion pathway protein
C1S73_RS12765	COG1077	Cell shape determining protein MreB Mrl
C1S73_RS12770	COG1792	Involved in formation and maintenance of cell shape
C1S73_RS12775	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1S73_RS12780	COG0424	maF-like protein
C1S73_RS12790	COG3164	Protein of unknown function
C1S73_RS12795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1S73_RS12800	COG0312	modulator of DNA gyrase
C1S73_RS12805	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1S73_RS12820	COG0564	pseudouridine synthase activity
C1S73_RS12825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1S73_RS12830	COG3028	Belongs to the UPF0307 family
C1S73_RS12835	COG0312	modulator of DNA gyrase
C1S73_RS12840	COG2239	Acts as a magnesium transporter
C1S73_RS12845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS12855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS12860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1S73_RS12870	COG1137	ATPase activity
C1S73_RS12875	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1S73_RS12885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1S73_RS12885	COG0517	IMP dehydrogenase activity
C1S73_RS12895	COG1127	ABC transporter
C1S73_RS12900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S73_RS12905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S73_RS12910	COG2854	intermembrane phospholipid transfer
C1S73_RS12920	COG5007	Belongs to the BolA IbaG family
C1S73_RS12930	COG0204	Acyl-transferase
C1S73_RS12935	COG0251	oxidation-reduction process
C1S73_RS12975	COG0456	acetyltransferase
C1S73_RS12985	COG0525	valine-tRNA ligase activity
C1S73_RS12990	COG2927	DNA polymerase III (CHI subunit)
C1S73_RS13000	COG0795	lipopolysaccharide-transporting ATPase activity
C1S73_RS13005	COG0795	lipopolysaccharide-transporting ATPase activity
C1S73_RS13015	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS13025	COG0726	polysaccharide deacetylase
C1S73_RS13030	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1S73_RS13040	COG1447	Phosphotransferase system cellobiose-specific component IIA
C1S73_RS13045	COG1486	melibiose metabolic process
C1S73_RS13050	COG3394	polysaccharide catabolic process
C1S73_RS13060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S73_RS13110	COG1012	belongs to the aldehyde dehydrogenase family
C1S73_RS13210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1S73_RS13215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1S73_RS13230	COG1872	DUF167
C1S73_RS13235	COG0762	integral membrane protein
C1S73_RS13240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1S73_RS13245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1S73_RS13260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1S73_RS13265	COG1678	Uncharacterized ACR, COG1678
C1S73_RS13270	COG0189	ligase activity
C1S73_RS13275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1S73_RS13300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1S73_RS13320	COG0191	fructose-bisphosphate aldolase activity
C1S73_RS13325	COG0668	transmembrane transport
C1S73_RS13340	COG0583	DNA-binding transcription factor activity
C1S73_RS13350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1S73_RS13360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1S73_RS13370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C1S73_RS13375	COG3079	Belongs to the UPF0149 family
C1S73_RS13380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S73_RS13385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S73_RS13405	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1S73_RS13415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1S73_RS13425	COG1595	DNA-templated transcription, initiation
C1S73_RS13435	COG3026	antisigma factor binding
C1S73_RS13445	COG0481	GTPase activity
C1S73_RS13460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1S73_RS13465	COG1381	Involved in DNA repair and RecF pathway recombination
C1S73_RS13470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1S73_RS13495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1S73_RS13500	COG3956	TIGRFAM MazG family protein
C1S73_RS13510	COG0148	phosphopyruvate hydratase activity
C1S73_RS13520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1S73_RS13550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1S73_RS13560	COG1546	Belongs to the CinA family
C1S73_RS13565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1S73_RS13670	COG3630	sodium ion export across plasma membrane
C1S73_RS13675	COG0511	ligase activity, forming carbon-carbon bonds
C1S73_RS13675	COG5016	pyruvate
C1S73_RS13680	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C1S73_RS13690	COG1238	metal cluster binding
C1S73_RS13695	COG0612	Peptidase, M16
C1S73_RS13715	COG4536	flavin adenine dinucleotide binding
C1S73_RS13720	COG4137	Cytochrome C assembly protein
C1S73_RS13725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1S73_RS13730	COG0228	four-way junction DNA binding
C1S73_RS13750	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1S73_RS13755	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1S73_RS13760	COG0237	dephospho-CoA kinase activity
C1S73_RS13770	COG1459	type II secretion system
C1S73_RS13775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1S73_RS13785	COG0157	Belongs to the NadC ModD family
C1S73_RS13795	COG2186	Transcriptional regulator
C1S73_RS13800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1S73_RS13805	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1S73_RS13810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S73_RS13825	COG0288	reversible hydration of carbon dioxide
C1S73_RS13830	COG0659	secondary active sulfate transmembrane transporter activity
C1S73_RS13835	COG1131	(ABC) transporter
C1S73_RS13840	COG0842	Transport permease protein
C1S73_RS13845	COG1560	Kdo2-lipid A biosynthetic process
C1S73_RS13860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1S73_RS13870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1S73_RS13885	COG1643	Atp-dependent helicase
C1S73_RS13890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1S73_RS13895	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1S73_RS13900	COG1049	propionate catabolic process, 2-methylcitrate cycle
C1S73_RS13920	COG0004	ammonium transporteR
C1S73_RS13925	COG1840	ABC-type Fe3 transport system, periplasmic component
C1S73_RS13935	COG3842	ATPase activity
C1S73_RS13940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1S73_RS13955	COG2971	BadF BadG BcrA BcrD
C1S73_RS13965	COG4608	Belongs to the ABC transporter superfamily
C1S73_RS13970	COG0444	Belongs to the ABC transporter superfamily
C1S73_RS13975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S73_RS13985	COG0747	negative chemotaxis
C1S73_RS13990	COG2205	protein histidine kinase activity
C1S73_RS13990	COG0784	Response regulator, receiver
C1S73_RS14005	COG0628	permease
C1S73_RS14035	COG0739	heme binding
C1S73_RS14040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1S73_RS14045	COG2239	Acts as a magnesium transporter
C1S73_RS14050	COG2027	D-alanyl-D-alanine carboxypeptidase
C1S73_RS14055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1S73_RS14060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S73_RS14065	COG1534	Rna-binding protein
C1S73_RS14070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1S73_RS14075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1S73_RS14080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1S73_RS14090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1S73_RS14110	COG0195	Participates in both transcription termination and antitermination
C1S73_RS14130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1S73_RS14150	COG0534	Mate efflux family protein
C1S73_RS14155	COG0826	peptidase U32
C1S73_RS14160	COG0826	peptidase U32
C1S73_RS14170	COG3154	lipid carrier protein
C1S73_RS14175	COG3153	acetyltransferase
C1S73_RS14200	COG0084	hydrolase, TatD family'
C1S73_RS14205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1S73_RS14210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1S73_RS14215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1S73_RS14225	COG0813	purine-nucleoside phosphorylase activity
C1S73_RS14235	COG0560	Phosphoserine phosphatase
C1S73_RS14245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1S73_RS14250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S73_RS14255	COG0583	DNA-binding transcription factor activity
C1S73_RS14290	COG1022	Amp-dependent synthetase and ligase
C1S73_RS14295	COG0741	lytic transglycosylase activity
C1S73_RS14320	COG4964	Belongs to the GSP D family
C1S73_RS14380	COG0583	DNA-binding transcription factor activity
C1S73_RS14385	COG0531	amino acid
C1S73_RS14390	COG2731	YhcH YjgK YiaL family protein
C1S73_RS14395	COG3250	beta-galactosidase activity
C1S73_RS14400	COG1609	Transcriptional regulator
C1S73_RS14405	COG0768	penicillin binding
C1S73_RS14415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1S73_RS14420	COG1085	galactose-1-phosphate uridylyltransferase
C1S73_RS14430	COG2017	converts alpha-aldose to the beta-anomer
C1S73_RS14435	COG1609	Transcriptional regulator
C1S73_RS14445	COG2211	Major facilitator Superfamily
C1S73_RS14450	COG1609	Transcriptional regulator
C1S73_RS14455	COG1263	PTS System
C1S73_RS14455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS14465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S73_RS14490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S73_RS14505	COG1757	Na H antiporter
C1S73_RS14510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1S73_RS14515	COG3976	FMN-binding domain protein
C1S73_RS14515	COG1053	succinate dehydrogenase
C1S73_RS14535	COG2376	Dihydroxyacetone kinase
C1S73_RS14540	COG1461	Dihydroxyacetone kinase
C1S73_RS14550	COG3284	Transcriptional regulator
C1S73_RS14555	COG3960	tartronate-semialdehyde synthase activity
C1S73_RS14560	COG3622	Belongs to the hyi family
C1S73_RS14565	COG2084	Dehydrogenase
C1S73_RS14570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1S73_RS14575	COG1349	DNA-binding transcription factor activity
C1S73_RS14585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1S73_RS14595	COG2271	Major facilitator Superfamily
C1S73_RS14600	COG0584	glycerophosphoryl diester phosphodiesterase
C1S73_RS14605	COG2171	N-acyltransferase activity
C1S73_RS14620	COG3141	response to X-ray
C1S73_RS14635	COG2261	transglycosylase associated protein
C1S73_RS14640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1S73_RS14645	COG1074	ATP-dependent DNA helicase activity
C1S73_RS14650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1S73_RS14675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1S73_RS14675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1S73_RS14690	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1S73_RS14695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1S73_RS14700	COG2166	iron-sulfur cluster assembly
C1S73_RS14705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1S73_RS14710	COG0693	protein deglycase activity
C1S73_RS14715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1S73_RS14720	COG3248	Nucleoside-binding outer membrane protein
C1S73_RS14740	COG1595	DNA-templated transcription, initiation
C1S73_RS14770	COG0271	Belongs to the BolA IbaG family
C1S73_RS14775	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1S73_RS14795	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1S73_RS14805	COG1477	protein flavinylation
C1S73_RS14820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1S73_RS14825	COG0514	ATP-dependent DNA helicase (RecQ)
C1S73_RS14830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S73_RS14845	COG0733	neurotransmitter:sodium symporter activity
C1S73_RS14870	COG1720	tRNA m6t6A37 methyltransferase activity
C1S73_RS14885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1S73_RS14925	COG3098	single-species biofilm formation
C1S73_RS14930	COG0564	pseudouridine synthase activity
C1S73_RS14945	COG0024	Methionine aminopeptidase
C1S73_RS14970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1S73_RS14975	COG0575	Belongs to the CDS family
C1S73_RS14985	COG0750	zinc metalloprotease
C1S73_RS14995	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C1S73_RS15000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1S73_RS15025	COG0587	DNA-directed DNA polymerase activity
C1S73_RS15045	COG0347	Belongs to the P(II) protein family
C1S73_RS15060	COG1388	LysM domain
C1S73_RS15060	COG0741	lytic transglycosylase activity
C1S73_RS15070	COG2226	methyltransferase
C1S73_RS15080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1S73_RS15100	COG1960	acyl-CoA dehydrogenase activity
C1S73_RS15105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1S73_RS15110	COG0121	glutamine amidotransferase
C1S73_RS15115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1S73_RS15120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1S73_RS15125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1S73_RS15130	COG2233	PERMEase
C1S73_RS15150	COG1393	Belongs to the ArsC family
C1S73_RS15155	COG4783	chaperone-mediated protein folding
C1S73_RS15170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1S73_RS15175	COG2716	regulation of RNA biosynthetic process
C1S73_RS15180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1S73_RS15185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1S73_RS15205	COG1393	Belongs to the ArsC family
C1S73_RS15230	COG2837	iron assimilation
C1S73_RS15235	COG2169	Transcriptional regulator
C1S73_RS15240	COG1486	melibiose metabolic process
C1S73_RS15245	COG2211	Major facilitator Superfamily
C1S73_RS15255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S73_RS15265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S73_RS15270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S73_RS15275	COG1334	flagellar protein FlaG
C1S73_RS15280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C1S73_RS15290	COG1516	flagellar protein fliS
C1S73_RS15310	COG1677	Flagellar hook-basal body complex protein FliE
C1S73_RS15320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1S73_RS15375	COG1987	bacterial-type flagellum assembly
C1S73_RS15380	COG1684	flagellar biosynthetic protein fliR
C1S73_RS15415	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1S73_RS15420	COG2198	Histidine kinase
C1S73_RS15420	COG0784	Response regulator, receiver
C1S73_RS15420	COG0643	Histidine kinase
C1S73_RS15425	COG2201	protein-glutamate methylesterase activity
C1S73_RS15430	COG1192	Involved in chromosome partitioning
C1S73_RS15440	COG0835	chemotaxis
C1S73_RS15450	COG4133	protoheme IX ABC transporter activity
C1S73_RS15455	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1S73_RS15460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1S73_RS15475	COG1138	Cytochrome C-type biogenesis protein
C1S73_RS15480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1S73_RS15490	COG3088	subunit of a heme lyase
C1S73_RS15490	COG4235	cytochrome complex assembly
C1S73_RS15495	COG2853	Lipoprotein
C1S73_RS15500	COG2067	long-chain fatty acid transport protein
C1S73_RS15505	COG2067	long-chain fatty acid transport protein
C1S73_RS15520	COG0183	Belongs to the thiolase family
C1S73_RS15535	COG2062	phosphohistidine phosphatase, SixA
C1S73_RS15545	COG2890	protein-(glutamine-N5) methyltransferase activity
C1S73_RS15555	COG2860	membrane
C1S73_RS15560	COG3101	peptidyl-lysine hydroxylation
C1S73_RS15585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1S73_RS15590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1S73_RS15595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1S73_RS15615	COG0285	dihydrofolate synthase activity
C1S73_RS15620	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1S73_RS15625	COG1286	toxin biosynthetic process
C1S73_RS15630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1S73_RS15635	COG0583	DNA-binding transcription factor activity
C1S73_RS15640	COG0745	RESPONSE REGULATOR receiver
C1S73_RS15650	COG2832	Protein of unknown function (DUF454)
C1S73_RS15670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1S73_RS15675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1S73_RS15680	COG0814	amino acid
C1S73_RS15685	COG0251	oxidation-reduction process
C1S73_RS15695	COG2964	Protein conserved in bacteria
C1S73_RS15710	COG2983	Belongs to the UPF0260 family
C1S73_RS15715	COG2261	transglycosylase associated protein
C1S73_RS15720	COG2985	domain, Protein
C1S73_RS15725	COG0076	glutamate decarboxylase activity
C1S73_RS15730	COG0668	transmembrane transport
C1S73_RS15740	COG0346	lactoylglutathione lyase activity
C1S73_RS15750	COG1785	Belongs to the alkaline phosphatase family
C1S73_RS15770	COG2226	methyltransferase
C1S73_RS15795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1S73_RS15800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S73_RS15810	COG3139	Protein of unknown function (DUF1315)
C1S73_RS15815	COG0252	asparaginase activity
C1S73_RS15820	COG0616	signal peptide processing
C1S73_RS15825	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S73_RS15825	COG1902	pentaerythritol trinitrate reductase activity
C1S73_RS15830	COG0778	Nitroreductase
C1S73_RS15835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1S73_RS15850	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1S73_RS15855	COG4269	membrane
C1S73_RS15875	COG3083	sulfuric ester hydrolase activity
C1S73_RS15900	COG1757	Na H antiporter
C1S73_RS15905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1S73_RS15910	COG2165	general secretion pathway protein
C1S73_RS15915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S73_RS15920	COG2095	MarC family integral membrane protein
C1S73_RS15925	COG1012	belongs to the aldehyde dehydrogenase family
C1S73_RS15925	COG1454	alcohol dehydrogenase
C1S73_RS15945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1S73_RS15950	COG4974	Belongs to the 'phage' integrase family
C1S73_RS16090	COG2003	Belongs to the UPF0758 family
C1S73_RS16175	COG0583	DNA-binding transcription factor activity
C1S73_RS16180	COG0840	transmembrane signaling receptor activity
C1S73_RS16190	COG3706	GGDEF domain
C1S73_RS16195	COG2239	Acts as a magnesium transporter
C1S73_RS16215	COG0189	ligase activity
C1S73_RS16275	COG3504	Conjugal transfer protein
C1S73_RS16300	COG3451	type IV secretory pathway VirB4
C1S73_RS16335	COG2056	Na+-H+ antiporter family
C1S73_RS16345	COG2885	chlorophyll binding
C1S73_RS16355	COG0346	lactoylglutathione lyase activity
C1S73_RS16360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1S73_RS16365	COG4660	Part of a membrane complex involved in electron transport
C1S73_RS16370	COG4659	FMN binding
C1S73_RS16375	COG4658	electron transport chain
C1S73_RS16380	COG4656	Part of a membrane complex involved in electron transport
C1S73_RS16390	COG4657	Part of a membrane complex involved in electron transport
C1S73_RS16395	COG1882	Formate acetyltransferase
C1S73_RS16405	COG0556	nucleotide-excision repair
C1S73_RS16415	COG2198	Histidine kinase
C1S73_RS16420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1S73_RS16425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1S73_RS16430	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1S73_RS16435	COG0315	cyclic pyranopterin monophosphate synthase activity
C1S73_RS16440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1S73_RS16445	COG0314	molybdopterin synthase activity
C1S73_RS16455	COG0601	transmembrane transport
C1S73_RS16460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S73_RS16465	COG0444	Belongs to the ABC transporter superfamily
C1S73_RS16475	COG0435	Glutathione S-transferase
C1S73_RS16480	COG3174	membrane
C1S73_RS16490	COG0857	belongs to the CobB CobQ family
C1S73_RS16490	COG0280	phosphate acetyltransferase
C1S73_RS16510	COG4120	Belongs to the binding-protein-dependent transport system permease family
C1S73_RS16515	COG1122	ATPase activity
C1S73_RS16520	COG0366	Alpha amylase catalytic
C1S73_RS16525	COG3706	GGDEF domain
C1S73_RS16530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S73_RS16535	COG3012	SEC-C Motif Domain Protein
C1S73_RS16535	COG3318	Belongs to the UPF0149 family
C1S73_RS16540	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1S73_RS16555	COG2186	Transcriptional regulator
C1S73_RS16565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S73_RS16565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S73_RS16580	COG2982	Protein involved in outer membrane biogenesis
C1S73_RS16585	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C1S73_RS16590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1S73_RS16595	COG0659	secondary active sulfate transmembrane transporter activity
C1S73_RS16605	COG1530	ribonuclease E activity
C1S73_RS16610	COG0564	pseudouridine synthase activity
C1S73_RS16615	COG0424	maF-like protein
C1S73_RS16620	COG1399	metal-binding, possibly nucleic acid-binding protein
C1S73_RS16635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1S73_RS16665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1S73_RS16680	COG0084	hydrolase, TatD family'
C1S73_RS16685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS16685	COG1263	PTS System
C1S73_RS16695	COG0733	neurotransmitter:sodium symporter activity
C1S73_RS16710	COG4667	esterase of the alpha-beta hydrolase superfamily
C1S73_RS16720	COG1940	carbohydrate kinase activity
C1S73_RS16725	COG0784	Response regulator, receiver
C1S73_RS16725	COG0835	chemotaxis
C1S73_RS16745	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS16750	COG0616	signal peptide processing
C1S73_RS16765	COG0539	negative regulation of cytoplasmic translation
C1S73_RS16775	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C1S73_RS16780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1S73_RS16785	COG0284	orotidine-5'-phosphate decarboxylase activity
C1S73_RS16790	COG4166	transmembrane transport
C1S73_RS16855	COG1309	transcriptional regulator
C1S73_RS16860	COG3009	Protein conserved in bacteria
C1S73_RS16865	COG3008	intermembrane lipid transfer
C1S73_RS16865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S73_RS16870	COG2995	paraquat-inducible protein a
C1S73_RS16875	COG1609	Transcriptional regulator
C1S73_RS16880	COG3258	Cytochrome c
C1S73_RS16885	COG2863	cytochrome
C1S73_RS16915	COG3250	beta-galactosidase activity
C1S73_RS16925	COG4580	involved in the transport of maltose and maltodextrins
C1S73_RS16940	COG2211	Major facilitator Superfamily
C1S73_RS16945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S73_RS16960	COG4232	protein-disulfide reductase activity
C1S73_RS16965	COG3118	belongs to the thioredoxin family
C1S73_RS16985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S73_RS16995	COG3153	acetyltransferase
C1S73_RS17010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS17025	COG0577	efflux transmembrane transporter activity
C1S73_RS17025	COG1136	(ABC) transporter
C1S73_RS17030	COG1136	(ABC) transporter
C1S73_RS17030	COG0577	efflux transmembrane transporter activity
C1S73_RS17045	COG2176	DNA-directed DNA polymerase activity
C1S73_RS17065	COG1196	nuclear chromosome segregation
C1S73_RS17130	COG5002	protein histidine kinase activity
C1S73_RS17130	COG3850	Histidine kinase
C1S73_RS17135	COG0745	RESPONSE REGULATOR receiver
C1S73_RS17140	COG0463	Glycosyl transferase, family 2
C1S73_RS17145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1S73_RS17155	COG0840	transmembrane signaling receptor activity
C1S73_RS17160	COG2964	Protein conserved in bacteria
C1S73_RS17175	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S73_RS17195	COG1032	radical SAM domain protein
C1S73_RS17200	COG1716	ATPase activity
C1S73_RS17200	COG5001	Diguanylate cyclase
C1S73_RS17205	COG4932	domain protein
C1S73_RS17205	COG5492	domain, Protein
C1S73_RS17220	COG0583	DNA-binding transcription factor activity
C1S73_RS17225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1S73_RS17235	COG2350	Protein conserved in bacteria
C1S73_RS17240	COG1607	acyl-coa hydrolase
C1S73_RS17265	COG1301	dicarboxylic acid transport
C1S73_RS17270	COG0159	tryptophan synthase activity
C1S73_RS17280	COG0135	phosphoribosylanthranilate isomerase activity
C1S73_RS17280	COG0134	indole-3-glycerol-phosphate synthase activity
C1S73_RS17290	COG0512	Glutamine amidotransferase of anthranilate synthase
C1S73_RS17295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1S73_RS17305	COG0613	PHP domain protein
C1S73_RS17310	COG0009	L-threonylcarbamoyladenylate synthase
C1S73_RS17320	COG1187	pseudouridine synthase activity
C1S73_RS17340	COG0417	DNA replication proofreading
C1S73_RS17345	COG2197	response regulator
C1S73_RS17350	COG0322	excinuclease ABC activity
C1S73_RS17390	COG0019	diaminopimelate decarboxylase activity
C1S73_RS17415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S73_RS17420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S73_RS17425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S73_RS17445	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1S73_RS17455	COG0437	4 iron, 4 sulfur cluster binding
C1S73_RS17460	COG3301	Polysulphide reductase, NrfD
C1S73_RS17465	COG1138	Cytochrome C-type biogenesis protein
C1S73_RS17475	COG4235	cytochrome complex assembly
C1S73_RS17475	COG3088	subunit of a heme lyase
C1S73_RS17485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S73_RS17510	COG2989	Protein conserved in bacteria
C1S73_RS17515	COG3108	Peptidase M15
C1S73_RS17520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S73_RS17545	COG0312	modulator of DNA gyrase
C1S73_RS17550	COG0312	modulator of DNA gyrase
C1S73_RS17555	COG0351	phosphomethylpyrimidine kinase
C1S73_RS17560	COG1116	anion transmembrane transporter activity
C1S73_RS17565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S73_RS17570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S73_RS17575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C1S73_RS17600	COG0671	phosphoesterase, PA-phosphatase related
C1S73_RS17605	COG0243	molybdopterin cofactor binding
C1S73_RS17610	COG3005	denitrification pathway
C1S73_RS17620	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS17640	COG0456	acetyltransferase
C1S73_RS17685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S73_RS17690	COG1929	Belongs to the glycerate kinase type-1 family
C1S73_RS17695	COG3835	regulator
C1S73_RS17705	COG1228	amidohydrolase
C1S73_RS17730	COG0546	phosphoglycolate phosphatase activity
C1S73_RS17740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1S73_RS17815	COG3408	Glycogen debranching enzyme
C1S73_RS17815	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1S73_RS17835	COG2814	Major facilitator Superfamily
C1S73_RS17850	COG2358	TRAP transporter, solute receptor (TAXI family
C1S73_RS17855	COG3047	cAMP biosynthetic process
C1S73_RS17860	COG1357	PFAM Pentapeptide repeats (8 copies)
C1S73_RS17875	COG0534	Mate efflux family protein
C1S73_RS17890	COG2076	Multidrug Resistance protein
C1S73_RS17935	COG0583	DNA-binding transcription factor activity
C1S73_RS17955	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C1S73_RS17970	COG3152	Membrane
C1S73_RS17980	COG2199	diguanylate cyclase activity
C1S73_RS17990	COG0561	phosphatase activity
C1S73_RS18000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1S73_RS18005	COG0564	pseudouridine synthase activity
C1S73_RS18010	COG0534	Mate efflux family protein
C1S73_RS18015	COG1609	Transcriptional regulator
C1S73_RS18020	COG3842	ATPase activity
C1S73_RS18025	COG2723	6-phospho-beta-galactosidase activity
C1S73_RS18030	COG0395	ABC-type sugar transport system, permease component
C1S73_RS18045	COG1609	Transcriptional regulator
C1S73_RS18050	COG4580	involved in the transport of maltose and maltodextrins
C1S73_RS18055	COG5001	Diguanylate cyclase
C1S73_RS18105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C1S73_RS18115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1S73_RS18120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C1S73_RS18130	COG2259	Doxx family
C1S73_RS18170	COG3623	hexulose-6-phosphate isomerase
C1S73_RS18175	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C1S73_RS18180	COG0561	phosphatase activity
C1S73_RS18230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S73_RS18235	COG0251	oxidation-reduction process
C1S73_RS18255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S73_RS18265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1S73_RS18270	COG2207	Transcriptional regulator
C1S73_RS18280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1S73_RS18285	COG0830	nickel cation binding
C1S73_RS18290	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C1S73_RS18295	COG0804	urea catabolic process
C1S73_RS18300	COG0832	Belongs to the urease beta subunit family
C1S73_RS18305	COG0831	urea catabolic process
C1S73_RS18310	COG0829	nickel cation binding
C1S73_RS18325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1S73_RS18350	COG0786	glutamate:sodium symporter activity
C1S73_RS18355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S73_RS18360	COG1131	(ABC) transporter
C1S73_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS18400	COG0786	glutamate:sodium symporter activity
C1S73_RS18425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1S73_RS18435	COG3279	Response regulator of the LytR AlgR family
C1S73_RS18440	COG3275	phosphorelay sensor kinase activity
C1S73_RS18460	COG1136	(ABC) transporter
C1S73_RS18470	COG0583	DNA-binding transcription factor activity
C1S73_RS18485	COG0772	Belongs to the SEDS family
C1S73_RS18510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S73_RS18510	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
C1S73_RS18520	COG0444	Belongs to the ABC transporter superfamily
C1S73_RS18525	COG4608	Belongs to the ABC transporter superfamily
C1S73_RS18560	COG1444	tRNA N-acetyltransferase activity
C1S73_RS18585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1S73_RS18590	COG1263	PTS System
C1S73_RS18590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS18595	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1S73_RS18610	COG4166	transmembrane transport
C1S73_RS18690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S73_RS18715	COG0406	alpha-ribazole phosphatase activity
C1S73_RS18740	COG1132	(ABC) transporter
C1S73_RS18760	COG2957	Belongs to the agmatine deiminase family
C1S73_RS18765	COG0531	amino acid
C1S73_RS18770	COG0549	Belongs to the carbamate kinase family
C1S73_RS18795	COG0800	Aldolase
C1S73_RS18800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S73_RS18805	COG1904	glucuronate isomerase
C1S73_RS18810	COG0246	Mannitol dehydrogenase
C1S73_RS18820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1S73_RS18830	COG2186	Transcriptional regulator
C1S73_RS18835	COG1312	Catalyzes the dehydration of D-mannonate
C1S73_RS18850	COG1595	DNA-templated transcription, initiation
C1S73_RS18870	COG0513	Belongs to the DEAD box helicase family
C1S73_RS18875	COG3713	MltA-interacting MipA family protein
C1S73_RS18880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1S73_RS18885	COG1757	Na H antiporter
C1S73_RS18890	COG1609	Transcriptional regulator
C1S73_RS18900	COG2153	protein acetylation
C1S73_RS18905	COG2258	MOSC domain
C1S73_RS18920	COG1522	sequence-specific DNA binding
C1S73_RS18935	COG1486	melibiose metabolic process
C1S73_RS18940	COG0583	DNA-binding transcription factor activity
C1S73_RS18950	COG0346	lactoylglutathione lyase activity
C1S73_RS18970	COG1349	DNA-binding transcription factor activity
C1S73_RS18975	COG2084	Dehydrogenase
C1S73_RS18980	COG3395	kinase activity
C1S73_RS18985	COG0235	Class ii aldolase
C1S73_RS18990	COG3622	Belongs to the hyi family
C1S73_RS18995	COG2610	gluconate transmembrane transporter activity
C1S73_RS19025	COG3634	alkyl hydroperoxide reductase activity
C1S73_RS19035	COG1846	Transcriptional regulator
C1S73_RS19040	COG1764	response to oxidative stress
C1S73_RS19095	COG0577	efflux transmembrane transporter activity
C1S73_RS19100	COG1136	(ABC) transporter
C1S73_RS19110	COG1349	DNA-binding transcription factor activity
C1S73_RS19115	COG1349	DNA-binding transcription factor activity
C1S73_RS19125	COG2222	sugar isomerase
C1S73_RS19130	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS19140	COG3716	PTS system mannose fructose sorbose family IID component
C1S73_RS19145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS19165	COG0826	peptidase U32
C1S73_RS19180	COG0840	transmembrane signaling receptor activity
C1S73_RS19185	COG0612	Peptidase, M16
C1S73_RS19215	COG3188	usher protein
C1S73_RS19220	COG3121	Chaperone
C1S73_RS19240	COG2188	Transcriptional regulator
C1S73_RS19250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS19250	COG1263	PTS System
C1S73_RS19250	COG2190	(PTS) system
C1S73_RS19255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S73_RS19260	COG0800	Aldolase
C1S73_RS19275	COG0739	heme binding
C1S73_RS19305	COG4604	ABC transporter, ATP-binding protein
C1S73_RS19310	COG4605	iron ion homeostasis
C1S73_RS19315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S73_RS19320	COG4607	ABC-type enterochelin transport system periplasmic component
C1S73_RS19325	COG0583	DNA-binding transcription factor activity
C1S73_RS19330	COG4771	TonB-dependent receptor
C1S73_RS19340	COG3214	Protein conserved in bacteria
C1S73_RS19345	COG2814	Major facilitator Superfamily
C1S73_RS19360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S73_RS19380	COG2203	Gaf domain
C1S73_RS19380	COG2199	diguanylate cyclase activity
C1S73_RS19415	COG2356	endonuclease I
C1S73_RS19435	COG1982	Orn Lys Arg decarboxylase major
C1S73_RS19440	COG0531	amino acid
C1S73_RS19465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C1S73_RS19470	COG0183	Belongs to the thiolase family
C1S73_RS19490	COG2814	Major facilitator Superfamily
C1S73_RS19490	COG0477	Major facilitator Superfamily
C1S73_RS19500	COG3962	Belongs to the TPP enzyme family
C1S73_RS19505	COG0673	inositol 2-dehydrogenase activity
C1S73_RS19510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S73_RS19535	COG0673	inositol 2-dehydrogenase activity
C1S73_RS19540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C1S73_RS19545	COG1162	GTPase activity
C1S73_RS19560	COG1999	signal sequence binding
C1S73_RS19585	COG0058	SHG alpha-glucan phosphorylase activity
C1S73_RS19590	COG1640	4-alpha-glucanotransferase
C1S73_RS19595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1S73_RS19600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1S73_RS19605	COG0366	Alpha amylase catalytic
C1S73_RS19630	COG3366	ferrous iron transmembrane transporter activity
C1S73_RS19635	COG0700	Nucleoside recognition
C1S73_RS19640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1S73_RS19645	COG3339	Conserved Protein
C1S73_RS19660	COG1301	dicarboxylic acid transport
C1S73_RS19690	COG0583	DNA-binding transcription factor activity
C1S73_RS19715	COG2095	MarC family integral membrane protein
C1S73_RS19720	COG4667	esterase of the alpha-beta hydrolase superfamily
C1S73_RS19730	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1S73_RS19735	COG0415	Belongs to the DNA photolyase family
C1S73_RS19760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S73_RS19765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S73_RS19785	COG1686	Belongs to the peptidase S11 family
C1S73_RS19810	COG0583	DNA-binding transcription factor activity
C1S73_RS19815	COG4628	conserved protein (DUF2132)
C1S73_RS19825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S73_RS19840	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1S73_RS19845	COG0628	permease
C1S73_RS19885	COG2988	succinylglutamate desuccinylase activity
C1S73_RS19890	COG0583	DNA-binding transcription factor activity
C1S73_RS19905	COG2814	Major facilitator Superfamily
C1S73_RS19915	COG0148	phosphopyruvate hydratase activity
C1S73_RS19920	COG0454	-acetyltransferase
C1S73_RS19930	COG0745	RESPONSE REGULATOR receiver
C1S73_RS19935	COG2205	protein histidine kinase activity
C1S73_RS19950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1S73_RS19955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1S73_RS19960	COG1882	Formate acetyltransferase
C1S73_RS19990	COG1294	oxidase, subunit
C1S73_RS19995	COG1271	oxidase subunit
C1S73_RS20010	COG3220	belongs to the UPF0276 family
C1S73_RS20025	COG0384	phenazine biosynthesis protein PhzF
C1S73_RS20030	COG0346	lactoylglutathione lyase activity
C1S73_RS20045	COG0488	(ABC) transporter
C1S73_RS20050	COG4628	conserved protein (DUF2132)
C1S73_RS20055	COG0583	DNA-binding transcription factor activity
C1S73_RS20060	COG0431	NADPH-dependent FMN reductase
C1S73_RS20075	COG0488	(ABC) transporter
C1S73_RS20090	COG0583	DNA-binding transcription factor activity
C1S73_RS20115	COG3226	Transcriptional regulator
C1S73_RS20130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1S73_RS20135	COG1280	lysine exporter protein (LysE YggA)
C1S73_RS20165	COG0737	Belongs to the 5'-nucleotidase family
C1S73_RS20170	COG3537	Alpha-1,2-mannosidase
C1S73_RS20175	COG3537	Alpha-1,2-mannosidase
C1S73_RS20185	COG3537	Alpha-1,2-mannosidase
C1S73_RS20190	COG3537	Alpha-1,2-mannosidase
C1S73_RS20195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS20205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S73_RS20205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S73_RS20210	COG0346	lactoylglutathione lyase activity
C1S73_RS20215	COG1349	DNA-binding transcription factor activity
C1S73_RS20220	COG1609	Transcriptional regulator
C1S73_RS20225	COG1263	PTS System
C1S73_RS20225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S73_RS20230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1S73_RS20255	COG0753	catalase activity
C1S73_RS20270	COG1335	isochorismatase
C1S73_RS20315	COG2801	Transposase and inactivated derivatives
C1S73_RS20320	COG2963	transposase activity
C1S73_RS20330	COG0583	DNA-binding transcription factor activity
C1S73_RS20335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1S73_RS20350	COG3448	diguanylate cyclase activity
C1S73_RS20350	COG4175	Glycine betaine
C1S73_RS20355	COG4176	ABC-type proline glycine betaine transport system permease component
C1S73_RS20365	COG1342	Belongs to the UPF0251 family
C1S73_RS20395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S73_RS20405	COG4948	Mandelate Racemase Muconate Lactonizing
C1S73_RS20445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S73_RS20455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S73_RS20470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S73_RS20490	COG0318	PFAM AMP-dependent synthetase and ligase
C1S73_RS20495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S73_RS20525	COG0786	glutamate:sodium symporter activity
C1S73_RS20530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1S73_RS20545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS20550	COG0583	DNA-binding transcription factor activity
C1S73_RS20590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1S73_RS20595	COG2197	response regulator
C1S73_RS20605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1S73_RS20605	COG0574	Belongs to the PEP-utilizing enzyme family
C1S73_RS20615	COG2807	transmembrane transport
C1S73_RS20625	COG0252	asparaginase activity
C1S73_RS20640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1S73_RS20645	COG0583	DNA-binding transcription factor activity
C1S73_RS20665	COG3122	Protein conserved in bacteria
C1S73_RS20680	COG2255	four-way junction helicase activity
C1S73_RS20690	COG3853	Toxic anion resistance protein (TelA)
C1S73_RS20700	COG1902	pentaerythritol trinitrate reductase activity
C1S73_RS20710	COG2814	Major facilitator Superfamily
C1S73_RS20715	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS20735	COG0583	DNA-binding transcription factor activity
C1S73_RS20745	COG0583	DNA-binding transcription factor activity
C1S73_RS20755	COG0513	Belongs to the DEAD box helicase family
C1S73_RS20800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S73_RS20805	COG2207	Transcriptional regulator
C1S73_RS20805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1S73_RS20810	COG0583	DNA-binding transcription factor activity
C1S73_RS20820	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS20835	COG3746	phosphate-selective porin O and P
C1S73_RS20860	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS20900	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1S73_RS20920	COG1278	Cold shock
C1S73_RS20945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1S73_RS20955	COG0625	glutathione transferase activity
C1S73_RS20960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S73_RS20970	COG1686	Belongs to the peptidase S11 family
C1S73_RS20980	COG2226	methyltransferase
C1S73_RS21000	COG0583	DNA-binding transcription factor activity
C1S73_RS21010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1S73_RS21025	COG1278	Cold shock
C1S73_RS21030	COG1741	Belongs to the pirin family
C1S73_RS21035	COG4667	esterase of the alpha-beta hydrolase superfamily
C1S73_RS21045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1S73_RS21050	COG4451	ribulose bisphosphate carboxylase, small
C1S73_RS21050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1S73_RS21055	COG0523	cobalamin synthesis protein
C1S73_RS21090	COG0395	ABC-type sugar transport system, permease component
C1S73_RS21095	COG1175	transmembrane transport
C1S73_RS21120	COG0589	response to stress
C1S73_RS21140	COG1720	tRNA m6t6A37 methyltransferase activity
C1S73_RS21145	COG0488	(ABC) transporter
C1S73_RS21150	COG1505	serine-type exopeptidase activity
C1S73_RS21170	COG2067	long-chain fatty acid transport protein
C1S73_RS21180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S73_RS21190	COG1858	cytochrome C peroxidase
C1S73_RS21205	COG0494	nUDIX hydrolase
C1S73_RS21220	COG0456	acetyltransferase
C1S73_RS21225	COG3321	synthase
C1S73_RS21225	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS21225	COG0604	alcohol dehydrogenase
C1S73_RS21265	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S73_RS21285	COG3383	formate dehydrogenase (NAD+) activity
C1S73_RS21305	COG0842	Transport permease protein
C1S73_RS21310	COG1131	(ABC) transporter
C1S73_RS21335	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C1S73_RS21345	COG4145	pantothenate transmembrane transporter activity
C1S73_RS21350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S73_RS21355	COG0800	Aldolase
C1S73_RS21370	COG2706	6-phosphogluconolactonase activity
C1S73_RS21375	COG0251	oxidation-reduction process
C1S73_RS21385	COG1881	PFAM PEBP family protein
C1S73_RS21400	COG0798	PFAM Bile acid sodium symporter
C1S73_RS21415	COG1733	regulation of RNA biosynthetic process
C1S73_RS21435	COG4989	oxidoreductase activity
C1S73_RS21445	COG1482	cell wall glycoprotein biosynthetic process
C1S73_RS21450	COG0383	alpha-mannosidase activity
C1S73_RS21455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS21455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS21455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS21460	COG2188	Transcriptional regulator
C1S73_RS21465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS21470	COG2213	PTS system mannitol-specific
C1S73_RS21475	COG1063	alcohol dehydrogenase
C1S73_RS21485	COG1072	(Pantothenic acid kinase))
C1S73_RS21490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1S73_RS21510	COG0814	amino acid
C1S73_RS21525	COG3314	Sporulation integral membrane protein YlbJ
C1S73_RS21550	COG0739	heme binding
C1S73_RS21555	COG5001	Diguanylate cyclase
C1S73_RS21560	COG1120	ATPase activity
C1S73_RS21570	COG2207	Transcriptional regulator
C1S73_RS21570	COG3708	Transcriptional regulator
C1S73_RS21575	COG4774	siderophore transport
C1S73_RS21590	COG0583	DNA-binding transcription factor activity
C1S73_RS21595	COG2814	Major facilitator Superfamily
C1S73_RS21615	COG0697	spore germination
C1S73_RS21630	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1S73_RS21650	COG1280	lysine exporter protein (LysE YggA)
C1S73_RS21660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1S73_RS21675	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1S73_RS21680	COG1845	cytochrome c oxidase, subunit III
C1S73_RS21700	COG1612	heme a metabolic process
C1S73_RS21715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1S73_RS21720	COG2814	Major facilitator Superfamily
C1S73_RS21725	COG0840	transmembrane signaling receptor activity
C1S73_RS21730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1S73_RS21760	COG2897	thiosulfate sulfurtransferase activity
C1S73_RS21815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1S73_RS21835	COG1914	H( )-stimulated, divalent metal cation uptake system
C1S73_RS21860	COG4989	oxidoreductase activity
C1S73_RS21875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1S73_RS21875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1S73_RS21895	COG1073	alpha beta
C1S73_RS21900	COG0583	DNA-binding transcription factor activity
C1S73_RS21920	COG4964	Belongs to the GSP D family
C1S73_RS21930	COG0455	bacterial-type flagellum organization
C1S73_RS21970	COG2885	chlorophyll binding
C1S73_RS21995	COG0402	S-adenosylhomocysteine deaminase activity
C1S73_RS22005	COG3706	GGDEF domain
C1S73_RS22030	COG4176	ABC-type proline glycine betaine transport system permease component
C1S73_RS22035	COG0517	IMP dehydrogenase activity
C1S73_RS22035	COG4175	Glycine betaine
C1S73_RS22050	COG0330	HflC and HflK could
C1S73_RS22065	COG5001	Diguanylate cyclase
C1S73_RS22065	COG4251	negative regulation of phosphorylation
C1S73_RS22065	COG3706	GGDEF domain
C1S73_RS22065	COG2203	Gaf domain
C1S73_RS22070	COG0784	Response regulator, receiver
C1S73_RS22070	COG2205	protein histidine kinase activity
C1S73_RS22080	COG0784	Response regulator, receiver
C1S73_RS22080	COG2205	protein histidine kinase activity
C1S73_RS22140	COG0494	nUDIX hydrolase
C1S73_RS22145	COG1051	belongs to the nudix hydrolase family
C1S73_RS22150	COG1794	racemase activity, acting on amino acids and derivatives
C1S73_RS22155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1S73_RS22160	COG5001	Diguanylate cyclase
C1S73_RS22170	COG1129	ABC transporter
C1S73_RS22175	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1S73_RS22185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S73_RS22190	COG1609	Transcriptional regulator
C1S73_RS22220	COG4607	ABC-type enterochelin transport system periplasmic component
C1S73_RS22225	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S73_RS22230	COG4605	iron ion homeostasis
C1S73_RS22235	COG4604	ABC transporter, ATP-binding protein
C1S73_RS22240	COG0789	Transcriptional regulator
C1S73_RS22250	COG4206	TonB-dependent receptor
C1S73_RS22285	COG1289	transmembrane transporter activity
C1S73_RS22290	COG0210	DNA helicase
C1S73_RS22300	COG1879	ABC-type sugar transport system periplasmic component
C1S73_RS22305	COG0784	Response regulator, receiver
C1S73_RS22305	COG2205	protein histidine kinase activity
C1S73_RS22305	COG2198	Histidine kinase
C1S73_RS22335	COG3119	arylsulfatase activity
C1S73_RS22340	COG3119	arylsulfatase activity
C1S73_RS22345	COG3063	Type IV pilus biogenesis stability protein PilW
C1S73_RS22350	COG0583	DNA-binding transcription factor activity
C1S73_RS22355	COG3119	arylsulfatase activity
C1S73_RS22360	COG0641	radical SAM
C1S73_RS22365	COG0714	Associated with various cellular activities
C1S73_RS22425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1S73_RS22435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1S73_RS22440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S73_RS22440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S73_RS22445	COG0583	DNA-binding transcription factor activity
C1S73_RS22450	COG1597	lipid kinase activity
C1S73_RS22455	COG3111	PFAM Bacterial OB fold (BOF) protein
C1S73_RS22475	COG0641	radical SAM
C1S73_RS22500	COG0501	Belongs to the peptidase M48B family
C1S73_RS22505	COG1704	LemA family
C1S73_RS22510	COG3069	C4-dicarboxylate transmembrane transporter activity
C1S73_RS22540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C1S73_RS22545	COG0739	heme binding
C1S73_RS22570	COG2204	response regulator
C1S73_RS22585	COG3501	Rhs element vgr protein
C1S73_RS22610	COG0515	serine threonine protein kinase
C1S73_RS22645	COG1522	sequence-specific DNA binding
C1S73_RS22715	COG4771	TonB-dependent receptor
C1S73_RS22730	COG3437	response regulator, receiver
C1S73_RS22730	COG4999	Histidine kinase
C1S73_RS22730	COG2205	protein histidine kinase activity
C1S73_RS22730	COG3850	Histidine kinase
C1S73_RS22735	COG3300	MHYT domain
C1S73_RS22735	COG5001	Diguanylate cyclase
C1S73_RS22740	COG2197	response regulator
C1S73_RS22745	COG3706	GGDEF domain
C1S73_RS22755	COG2197	response regulator
C1S73_RS22765	COG0778	Nitroreductase
C1S73_RS22775	COG0835	chemotaxis
C1S73_RS22775	COG0784	Response regulator, receiver
C1S73_RS22780	COG2165	general secretion pathway protein
C1S73_RS22790	COG2962	Rard protein
C1S73_RS22805	COG0671	phosphoesterase, PA-phosphatase related
C1S73_RS22860	COG2067	long-chain fatty acid transport protein
C1S73_RS22865	COG5642	Protein of unknown function (DUF2384)
C1S73_RS22875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S73_RS22875	COG2755	lipolytic protein G-D-S-L family
C1S73_RS22885	COG1216	Glycosyl transferase, family 2
C1S73_RS22885	COG0463	Glycosyl transferase, family 2
C1S73_RS22895	COG1902	pentaerythritol trinitrate reductase activity
C1S73_RS22900	COG0346	lactoylglutathione lyase activity
C1S73_RS22935	COG2815	serine threonine protein kinase
C1S73_RS22935	COG0515	serine threonine protein kinase
C1S73_RS22970	COG0631	protein serine/threonine phosphatase activity
C1S73_RS23060	COG0420	3'-5' exonuclease activity
C1S73_RS23065	COG0419	ATPase involved in DNA repair
C1S73_RS23075	COG3469	chitinase activity
C1S73_RS23105	COG3040	lipid binding
C1S73_RS23115	COG1288	antiporter activity
C1S73_RS23125	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C1S73_RS23140	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C1S73_RS23150	COG1472	Belongs to the glycosyl hydrolase 3 family
C1S73_RS23155	COG0583	DNA-binding transcription factor activity
C1S73_RS23160	COG0277	FAD linked oxidase domain protein
C1S73_RS23210	COG2199	diguanylate cyclase activity
C1S73_RS23220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S73_RS23230	COG2116	formate transmembrane transporter activity
C1S73_RS23250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1S73_RS23270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S73_RS23280	COG0534	Mate efflux family protein
C1S73_RS23285	COG2205	protein histidine kinase activity
C1S73_RS23285	COG0745	RESPONSE REGULATOR receiver
C1S73_RS23285	COG3292	Two component regulator propeller
C1S73_RS23295	COG3118	belongs to the thioredoxin family
C1S73_RS23300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1S73_RS23330	COG1566	PFAM secretion protein HlyD family protein
C1S73_RS23340	COG0628	permease
C1S73_RS23350	COG1482	cell wall glycoprotein biosynthetic process
C1S73_RS23355	COG2271	Major facilitator Superfamily
C1S73_RS23360	COG3851	Histidine kinase
C1S73_RS23365	COG2197	response regulator
C1S73_RS23445	COG1328	CTP reductase activity
C1S73_RS23450	COG0602	queuosine metabolic process
C1S73_RS23455	COG0534	Mate efflux family protein
C1S73_RS23460	COG2207	Transcriptional regulator
C1S73_RS23480	COG3111	PFAM Bacterial OB fold (BOF) protein
C1S73_RS23490	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1S73_RS23495	COG4149	molybdate abc transporter
C1S73_RS23500	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1S73_RS23510	COG5001	Diguanylate cyclase
C1S73_RS23510	COG3706	GGDEF domain
C1S73_RS23510	COG4251	negative regulation of phosphorylation
C1S73_RS23510	COG2203	Gaf domain
C1S73_RS23540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1S73_RS23545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1S73_RS23555	COG0745	RESPONSE REGULATOR receiver
C1S73_RS23570	COG3140	Belongs to the UPF0181 family
C1S73_RS23590	COG0023	Translation Initiation Factor
C1S73_RS23610	COG1042	CoA-binding domain protein
C1S73_RS23610	COG0045	succinate-CoA ligase (ADP-forming) activity
C1S73_RS23610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S73_RS23615	COG0583	DNA-binding transcription factor activity
C1S73_RS23630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1S73_RS23635	COG3447	MASE1 domain protein
C1S73_RS23635	COG5002	protein histidine kinase activity
C1S73_RS23635	COG5001	Diguanylate cyclase
C1S73_RS23645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1S73_RS23650	COG1984	allophanate hydrolase subunit 2
C1S73_RS23660	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1S73_RS23665	COG4181	ATPase activity
C1S73_RS23675	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1S73_RS23680	COG5001	Diguanylate cyclase
C1S73_RS23680	COG3300	MHYT domain
C1S73_RS23690	COG0484	heat shock protein binding
C1S73_RS23725	COG2050	protein possibly involved in aromatic compounds catabolism
C1S73_RS23740	COG2067	long-chain fatty acid transport protein
C1S73_RS23745	COG2267	carboxylic ester hydrolase activity
C1S73_RS23775	COG0861	Integral membrane protein TerC family
C1S73_RS23780	COG0737	Belongs to the 5'-nucleotidase family
C1S73_RS23785	COG3593	DNA synthesis involved in DNA repair
C1S73_RS23795	COG0583	DNA-binding transcription factor activity
C1S73_RS23805	COG2116	formate transmembrane transporter activity
C1S73_RS23815	COG3038	cytochrome b561
C1S73_RS23830	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C1S73_RS23835	COG0513	Belongs to the DEAD box helicase family
C1S73_RS23840	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C1S73_RS23850	COG0840	transmembrane signaling receptor activity
C1S73_RS23860	COG0546	phosphoglycolate phosphatase activity
C1S73_RS23865	COG0784	Response regulator, receiver
C1S73_RS23865	COG3437	response regulator, receiver
C1S73_RS23880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S73_RS23890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1S73_RS23900	COG2207	Transcriptional regulator
C1S73_RS23905	COG1979	alcohol dehydrogenase
C1S73_RS23915	COG1126	abc transporter atp-binding protein
C1S73_RS23920	COG0765	amino acid transport
C1S73_RS23925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S73_RS23930	COG0765	amino acid transport
C1S73_RS23935	COG2203	Gaf domain
C1S73_RS23935	COG2199	diguanylate cyclase activity
C1S73_RS23935	COG2200	EAL domain
C1S73_RS23950	COG1609	Transcriptional regulator
C1S73_RS23955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS23955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS23960	COG1105	Belongs to the carbohydrate kinase PfkB family
C1S73_RS23965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS23965	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1S73_RS23965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS23995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS24000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S73_RS24010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1S73_RS24020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1S73_RS24025	COG0509	glycine decarboxylation via glycine cleavage system
C1S73_RS24075	COG1733	regulation of RNA biosynthetic process
C1S73_RS24095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1S73_RS24100	COG0583	DNA-binding transcription factor activity
C1S73_RS24115	COG1132	(ABC) transporter
C1S73_RS24220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S73_RS24240	COG0523	cobalamin synthesis protein
C1S73_RS24255	COG1024	Enoyl-CoA hydratase
C1S73_RS24260	COG0604	alcohol dehydrogenase
C1S73_RS24260	COG3321	synthase
C1S73_RS24290	COG0628	permease
C1S73_RS24305	COG3038	cytochrome b561
C1S73_RS24325	COG0739	heme binding
C1S73_RS24335	COG0583	DNA-binding transcription factor activity
C1S73_RS24345	COG1271	oxidase subunit
C1S73_RS24350	COG1294	oxidase, subunit
C1S73_RS24395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S73_RS24395	COG2146	nitrite reductase [NAD(P)H] activity
C1S73_RS24400	COG1116	anion transmembrane transporter activity
C1S73_RS24405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S73_RS24410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S73_RS24410	COG1116	anion transmembrane transporter activity
C1S73_RS24440	COG0243	molybdopterin cofactor binding
C1S73_RS24450	COG5001	Diguanylate cyclase
C1S73_RS24450	COG5002	protein histidine kinase activity
C1S73_RS24455	COG0814	amino acid
C1S73_RS24485	COG1785	Belongs to the alkaline phosphatase family
C1S73_RS24500	COG0745	RESPONSE REGULATOR receiver
C1S73_RS24530	COG2847	Copper chaperone PCu(A)C
C1S73_RS24535	COG0443	Heat shock 70 kDa protein
C1S73_RS24580	COG3119	arylsulfatase activity
C1S73_RS24620	COG1538	Outer membrane efflux protein
C1S73_RS24645	COG4160	amino acid transport
C1S73_RS24650	COG4215	(ABC) transporter
C1S73_RS24655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S73_RS24660	COG1126	abc transporter atp-binding protein
C1S73_RS24700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S73_RS24710	COG1012	belongs to the aldehyde dehydrogenase family
C1S73_RS24725	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S73_RS24725	COG1902	pentaerythritol trinitrate reductase activity
C1S73_RS24735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1S73_RS24740	COG1845	cytochrome c oxidase, subunit III
C1S73_RS24745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1S73_RS24750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1S73_RS24755	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS24765	COG1024	Enoyl-CoA hydratase
C1S73_RS24770	COG1024	Enoyl-CoA hydratase
C1S73_RS24785	COG0183	Belongs to the thiolase family
C1S73_RS24795	COG1960	acyl-CoA dehydrogenase activity
C1S73_RS24800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1S73_RS24805	COG1024	Enoyl-CoA hydratase
C1S73_RS24830	COG3278	Belongs to the heme-copper respiratory oxidase family
C1S73_RS24845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1S73_RS24850	COG0513	Belongs to the DEAD box helicase family
C1S73_RS24855	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1S73_RS24870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1S73_RS24890	COG1119	ATPase activity
C1S73_RS24895	COG3300	MHYT domain
C1S73_RS24895	COG5001	Diguanylate cyclase
C1S73_RS24915	COG0513	Belongs to the DEAD box helicase family
C1S73_RS24935	COG0523	cobalamin synthesis protein
C1S73_RS24970	COG3530	Putative quorum-sensing-regulated virulence factor
C1S73_RS25005	COG3186	Phenylalanine-4-hydroxylase
C1S73_RS25015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S73_RS25020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S73_RS25040	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1S73_RS25045	COG1454	alcohol dehydrogenase
C1S73_RS25050	COG2133	pyrroloquinoline quinone binding
C1S73_RS25055	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1S73_RS25065	COG0783	Belongs to the Dps family
C1S73_RS25070	COG0840	transmembrane signaling receptor activity
C1S73_RS25095	COG0784	Response regulator, receiver
C1S73_RS25095	COG2205	protein histidine kinase activity
C1S73_RS25100	COG1538	Outer membrane efflux protein
C1S73_RS25130	COG0577	efflux transmembrane transporter activity
C1S73_RS25130	COG1136	(ABC) transporter
C1S73_RS25150	COG2199	diguanylate cyclase activity
C1S73_RS25160	COG3036	rescue of stalled ribosome
C1S73_RS25165	COG1278	Cold shock
C1S73_RS25195	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S73_RS25200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1S73_RS25210	COG0840	transmembrane signaling receptor activity
C1S73_RS25230	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1S73_RS25245	COG2197	response regulator
C1S73_RS25250	COG3850	Histidine kinase
C1S73_RS25255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1S73_RS25275	COG3005	denitrification pathway
C1S73_RS25295	COG0183	Belongs to the thiolase family
C1S73_RS25305	COG1280	lysine exporter protein (LysE YggA)
C1S73_RS25315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S73_RS25320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S73_RS25400	COG0673	inositol 2-dehydrogenase activity
C1S73_RS25405	COG2205	protein histidine kinase activity
C1S73_RS25405	COG5002	protein histidine kinase activity
C1S73_RS25405	COG0784	Response regulator, receiver
C1S73_RS25435	COG1522	sequence-specific DNA binding
C1S73_RS25440	COG0531	amino acid
C1S73_RS25455	COG2205	protein histidine kinase activity
C1S73_RS25460	COG0745	RESPONSE REGULATOR receiver
C1S73_RS25485	COG1566	PFAM secretion protein HlyD family protein
C1S73_RS25490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1S73_RS25495	COG2239	Acts as a magnesium transporter
C1S73_RS25500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1S73_RS25505	COG0402	S-adenosylhomocysteine deaminase activity
C1S73_RS25520	COG1418	mRNA catabolic process
C1S73_RS25545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S73_RS25565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1S73_RS25580	COG4221	oxidoreductase activity
C1S73_RS25585	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C1S73_RS25590	COG0745	RESPONSE REGULATOR receiver
C1S73_RS25595	COG2205	protein histidine kinase activity
C1S73_RS25605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1S73_RS25610	COG2194	sulfuric ester hydrolase activity
C1S73_RS25620	COG0673	inositol 2-dehydrogenase activity
C1S73_RS25630	COG1335	isochorismatase
C1S73_RS25645	COG2814	Major facilitator Superfamily
C1S73_RS25665	COG0583	DNA-binding transcription factor activity
C1S73_RS25670	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1S73_RS25685	COG0583	DNA-binding transcription factor activity
C1S73_RS25730	COG0366	Alpha amylase catalytic
C1S73_RS25735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S73_RS25740	COG0784	Response regulator, receiver
C1S73_RS25740	COG0835	chemotaxis
C1S73_RS25755	COG0748	coenzyme F420 binding
C1S73_RS25760	COG3721	Heme iron utilization protein
C1S73_RS25770	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1S73_RS25775	COG0811	peptide transport
C1S73_RS25780	COG0848	biopolymer transport protein
C1S73_RS25790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S73_RS25795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1S73_RS25845	COG3217	Mosc domain protein beta barrel domain protein
C1S73_RS25845	COG3217	Mosc domain protein beta barrel domain protein
C1S73_RS25845	COG0633	Ferredoxin
C1S73_RS25845	COG0633	Ferredoxin
C1S73_RS25850	COG0401	homolog of Blt101
C1S73_RS25865	COG2354	Protein conserved in bacteria
C1S73_RS25895	COG3833	ABC-type maltose transport systems, permease component
C1S73_RS25900	COG1175	transmembrane transport
C1S73_RS25915	COG3842	ATPase activity
C1S73_RS25920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1S73_RS25935	COG0489	protein tyrosine kinase activity
C1S73_RS25935	COG3206	protein involved in exopolysaccharide biosynthesis
C1S73_RS25985	COG1309	transcriptional regulator
C1S73_RS25990	COG2130	NADP-dependent
C1S73_RS26000	COG0753	catalase activity
C1S73_RS26005	COG2084	Dehydrogenase
C1S73_RS26015	COG0583	DNA-binding transcription factor activity
C1S73_RS26025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS26030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS26040	COG2207	Transcriptional regulator
C1S73_RS26045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S73_RS26045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS26045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S73_RS26070	COG0583	DNA-binding transcription factor activity
C1S73_RS26075	COG1566	PFAM secretion protein HlyD family protein
C1S73_RS26105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1S73_RS26115	COG1301	dicarboxylic acid transport
C1S73_RS26120	COG1252	NADH dehydrogenase
C1S73_RS26130	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C1S73_RS26135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1S73_RS26140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1S73_RS26185	COG1028	Short-chain dehydrogenase reductase Sdr
C1S73_RS26190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1S73_RS26200	COG0573	inorganic phosphate transmembrane transporter activity
C1S73_RS26210	COG4191	Histidine kinase
C1S73_RS26220	COG0110	maltose O-acetyltransferase activity
C1S73_RS26245	COG2197	response regulator
C1S73_RS26255	COG0840	transmembrane signaling receptor activity
C1S73_RS26275	COG0714	Associated with various cellular activities
C1S73_RS26295	COG2304	oxidoreductase activity
C1S73_RS26310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1S73_RS26315	COG0581	inorganic phosphate transmembrane transporter activity
C1S73_RS26320	COG0573	inorganic phosphate transmembrane transporter activity
C1S73_RS26330	COG0840	transmembrane signaling receptor activity
C1S73_RS26360	COG4771	TonB-dependent receptor
C1S73_RS26365	COG1770	oligopeptidase
C1S73_RS26370	COG0513	Belongs to the DEAD box helicase family
C1S73_RS26380	COG1388	LysM domain
C1S73_RS26380	COG1376	ErfK ybiS ycfS ynhG family protein
C1S73_RS26385	COG0415	Belongs to the DNA photolyase family
C1S73_RS26390	COG0789	Transcriptional regulator
C1S73_RS26395	COG3272	Protein of unknown function (DUF1722)
C1S73_RS26405	COG0813	purine-nucleoside phosphorylase activity
C1S73_RS26435	COG1566	PFAM secretion protein HlyD family protein
C1S73_RS26445	COG1122	ATPase activity
C1S73_RS26475	COG0348	domain, Protein
C1S73_RS26480	COG0437	4 iron, 4 sulfur cluster binding
C1S73_RS26485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S73_RS26505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1S73_RS26515	COG1067	ATP-dependent peptidase activity
C1S73_RS26525	COG4172	Belongs to the ABC transporter superfamily
C1S73_RS26530	COG1505	serine-type exopeptidase activity
C1S73_RS26535	COG0583	DNA-binding transcription factor activity
C1S73_RS26540	COG1620	l-lactate permease
C1S73_RS26545	COG1304	FMN binding
C1S73_RS26560	COG0668	transmembrane transport
C1S73_RS26580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1S73_RS26605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1S73_RS26635	COG1063	alcohol dehydrogenase
C1S73_RS26640	COG0156	8-amino-7-oxononanoate synthase activity
C1S73_RS26665	COG0745	RESPONSE REGULATOR receiver
C1S73_RS26690	COG0346	lactoylglutathione lyase activity
C1S73_RS26750	COG3188	usher protein
C1S73_RS26760	COG3539	Fimbrial protein
C1S73_RS26770	COG0583	DNA-binding transcription factor activity
C1S73_RS26780	COG2200	EAL domain
C1S73_RS26840	COG1987	bacterial-type flagellum assembly
C1S73_RS26850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1S73_RS26865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S73_RS26875	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C1S73_RS26880	COG1516	flagellar protein fliS
C1S73_RS26895	COG1580	Controls the rotational direction of flagella during chemotaxis
C1S73_RS26900	COG1191	sigma factor activity
C1S73_RS26905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1S73_RS26910	COG1360	Flagellar Motor Protein
C1S73_RS26935	COG0384	phenazine biosynthesis protein PhzF
C1S73_RS26975	COG2226	methyltransferase
C1S73_RS26990	COG3710	Transcriptional regulator
C1S73_RS26995	COG1253	flavin adenine dinucleotide binding
C1S73_RS27005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1S73_RS27010	COG1473	amidohydrolase
C1S73_RS27020	COG1522	sequence-specific DNA binding
C1S73_RS27040	COG0583	DNA-binding transcription factor activity
C1S73_RS27065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S73_RS27070	COG1256	bacterial-type flagellum assembly
C1S73_RS27070	COG4786	Flagellar basal body rod
C1S73_RS27080	COG1706	bacterial-type flagellum-dependent cell motility
C1S73_RS27085	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1S73_RS27090	COG4786	Flagellar basal body rod
C1S73_RS27095	COG4787	bacterial-type flagellum-dependent cell motility
C1S73_RS27100	COG1749	Flagellar hook protein flgE
C1S73_RS27105	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C1S73_RS27110	COG1558	bacterial-type flagellum-dependent cell motility
C1S73_RS27115	COG1815	bacterial-type flagellum-dependent cell motility
C1S73_RS27135	COG1388	LysM domain
C1S73_RS27135	COG0741	lytic transglycosylase activity
C1S73_RS27160	COG1760	l-serine dehydratase
C1S73_RS27165	COG3104	oligopeptide transport
C1S73_RS27190	COG0583	DNA-binding transcription factor activity
C1S73_RS27200	COG2866	Carboxypeptidase
C1S73_RS27205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S73_RS27215	COG2990	Protein conserved in bacteria
C1S73_RS27240	COG3842	ATPase activity
C1S73_RS27255	COG1840	ABC-type Fe3 transport system, periplasmic component
C1S73_RS27265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1S73_RS27285	COG3240	lipase activity
C1S73_RS27330	COG1011	Hydrolase
C1S73_RS27355	COG1765	OsmC-like protein
C1S73_RS27360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S73_RS27360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S73_RS27375	COG3046	protein related to deoxyribodipyrimidine photolyase
C1S73_RS27380	COG0415	Belongs to the DNA photolyase family
C1S73_RS27385	COG3706	GGDEF domain
C1S73_RS27400	COG3706	GGDEF domain
C1S73_RS27420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1S73_RS27425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1S73_RS27445	COG3033	Beta-eliminating lyase
C1S73_RS27465	COG0579	oxidoreductase
C1S73_RS27485	COG1114	Component of the transport system for branched-chain amino acids
C1S73_RS27525	COG0583	DNA-binding transcription factor activity
C1S73_RS27550	COG0189	ligase activity
C1S73_RS27555	COG0189	ligase activity
C1S73_RS27555	COG4067	protein conserved in archaea
C1S73_RS27565	COG1166	arginine decarboxylase activity
C1S73_RS27570	COG0010	Belongs to the arginase family
C1S73_RS27575	COG2814	Major facilitator Superfamily
C1S73_RS27580	COG1770	oligopeptidase
C1S73_RS27595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1S73_RS27600	COG1121	(ABC) transporter
C1S73_RS27605	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1S73_RS27650	COG0848	biopolymer transport protein
C1S73_RS27655	COG0811	peptide transport
C1S73_RS27660	COG0811	peptide transport
C1S73_RS27680	COG0745	RESPONSE REGULATOR receiver
C1S73_RS27685	COG0584	glycerophosphoryl diester phosphodiesterase
C1S73_RS27695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family