locus-tag	class	description
GPX95_RS00005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPX95_RS00015	COG2350	Protein conserved in bacteria
GPX95_RS00020	COG1607	acyl-coa hydrolase
GPX95_RS00025	COG2917	probably involved in intracellular septation
GPX95_RS00040	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPX95_RS00045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPX95_RS00055	COG2116	formate transmembrane transporter activity
GPX95_RS00060	COG4459	periplasmic nitrate reductase
GPX95_RS00065	COG3005	denitrification pathway
GPX95_RS00070	COG0243	molybdopterin cofactor binding
GPX95_RS00085	COG1162	GTPase activity
GPX95_RS00090	COG1227	inorganic diphosphatase activity
GPX95_RS00115	COG4171	peptide transport system, permease
GPX95_RS00120	COG4168	peptide transport system, permease
GPX95_RS00130	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPX95_RS00135	COG1842	Phage shock protein A
GPX95_RS00150	COG2818	Glycosylase
GPX95_RS00155	COG0626	cystathionine gamma-synthase activity
GPX95_RS00165	COG0733	neurotransmitter:sodium symporter activity
GPX95_RS00170	COG0564	pseudouridine synthase activity
GPX95_RS00175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPX95_RS00180	COG4136	ATPase activity
GPX95_RS00185	COG4135	transport system, permease component
GPX95_RS00190	COG4134	Bacterial extracellular solute-binding protein
GPX95_RS00200	COG3313	Fe-S protein
GPX95_RS00210	COG0842	Transport permease protein
GPX95_RS00215	COG1131	(ABC) transporter
GPX95_RS00225	COG0814	amino acid
GPX95_RS00235	COG2239	Acts as a magnesium transporter
GPX95_RS00255	COG4934	collagen metabolic process
GPX95_RS00285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX95_RS00300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPX95_RS00305	COG5002	protein histidine kinase activity
GPX95_RS00310	COG0745	RESPONSE REGULATOR receiver
GPX95_RS00320	COG1061	Type III restriction enzyme res subunit
GPX95_RS00325	COG1187	pseudouridine synthase activity
GPX95_RS00330	COG2814	Major facilitator Superfamily
GPX95_RS00340	COG0702	epimerase
GPX95_RS00345	COG0534	Mate efflux family protein
GPX95_RS00350	COG4181	ATPase activity
GPX95_RS00365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPX95_RS00375	COG1748	Saccharopine dehydrogenase
GPX95_RS00380	COG0019	diaminopimelate decarboxylase activity
GPX95_RS00390	COG1538	Outer membrane efflux protein
GPX95_RS00435	COG0583	DNA-binding transcription factor activity
GPX95_RS00445	COG1451	nucleotide metabolic process
GPX95_RS00460	COG3063	Type IV pilus biogenesis stability protein PilW
GPX95_RS00465	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPX95_RS00485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPX95_RS00500	COG3290	protein histidine kinase activity
GPX95_RS00505	COG4565	transcriptional regulatory protein
GPX95_RS00515	COG0835	chemotaxis
GPX95_RS00515	COG0784	Response regulator, receiver
GPX95_RS00530	COG3706	GGDEF domain
GPX95_RS00530	COG0745	RESPONSE REGULATOR receiver
GPX95_RS00555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPX95_RS00560	COG2017	converts alpha-aldose to the beta-anomer
GPX95_RS00570	COG2200	EAL domain
GPX95_RS00570	COG2199	diguanylate cyclase activity
GPX95_RS00575	COG4135	transport system, permease component
GPX95_RS00580	COG0398	Pfam SNARE associated Golgi protein
GPX95_RS00590	COG0493	'glutamate synthase
GPX95_RS00615	COG0753	catalase activity
GPX95_RS00665	COG1294	oxidase, subunit
GPX95_RS00670	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPX95_RS00670	COG1136	(ABC) transporter
GPX95_RS00675	COG0577	efflux transmembrane transporter activity
GPX95_RS00675	COG1136	(ABC) transporter
GPX95_RS00680	COG0577	efflux transmembrane transporter activity
GPX95_RS00680	COG1136	(ABC) transporter
GPX95_RS00700	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPX95_RS00705	COG2723	6-phospho-beta-galactosidase activity
GPX95_RS00710	COG1609	Transcriptional regulator
GPX95_RS00715	COG0251	oxidation-reduction process
GPX95_RS00720	COG2731	YhcH YjgK YiaL family protein
GPX95_RS00725	COG0584	glycerophosphoryl diester phosphodiesterase
GPX95_RS00730	COG1349	DNA-binding transcription factor activity
GPX95_RS00735	COG3842	ATPase activity
GPX95_RS00740	COG0395	ABC-type sugar transport system, permease component
GPX95_RS00745	COG1175	transmembrane transport
GPX95_RS00750	COG1653	transport
GPX95_RS00760	COG0811	peptide transport
GPX95_RS00765	COG0811	peptide transport
GPX95_RS00770	COG0848	biopolymer transport protein
GPX95_RS00795	COG0534	Mate efflux family protein
GPX95_RS00815	COG0791	NLP P60 protein
GPX95_RS00820	COG0840	transmembrane signaling receptor activity
GPX95_RS00835	COG1940	carbohydrate kinase activity
GPX95_RS00845	COG0303	'Molybdopterin
GPX95_RS00850	COG0746	molybdenum cofactor guanylyltransferase activity
GPX95_RS00855	COG3842	ATPase activity
GPX95_RS00860	COG4662	Binding-protein-dependent transport system inner membrane component
GPX95_RS00870	COG2204	response regulator
GPX95_RS00875	COG3852	Histidine kinase
GPX95_RS00880	COG0488	(ABC) transporter
GPX95_RS00885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPX95_RS00915	COG0243	molybdopterin cofactor binding
GPX95_RS00915	COG3383	formate dehydrogenase (NAD+) activity
GPX95_RS00920	COG0437	4 iron, 4 sulfur cluster binding
GPX95_RS00935	COG0004	ammonium transporteR
GPX95_RS00940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPX95_RS00950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPX95_RS00965	COG2996	Protein conserved in bacteria
GPX95_RS00970	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPX95_RS00970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPX95_RS00975	COG3008	intermembrane lipid transfer
GPX95_RS00980	COG2995	paraquat-inducible protein a
GPX95_RS00985	COG1132	(ABC) transporter
GPX95_RS00990	COG1956	GAF domain-containing protein
GPX95_RS00995	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPX95_RS01010	COG0308	aminopeptidase N
GPX95_RS01020	COG2902	Dehydrogenase
GPX95_RS01025	COG0167	dihydroorotate dehydrogenase activity
GPX95_RS01035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPX95_RS01035	COG0116	Belongs to the methyltransferase superfamily
GPX95_RS01060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPX95_RS01065	COG1067	ATP-dependent peptidase activity
GPX95_RS01070	COG3120	sequence-specific DNA binding
GPX95_RS01085	COG2205	protein histidine kinase activity
GPX95_RS01085	COG0784	Response regulator, receiver
GPX95_RS01115	COG2010	Cytochrome c
GPX95_RS01125	COG2217	Heavy metal translocating P-type atpase
GPX95_RS01140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPX95_RS01145	COG0589	response to stress
GPX95_RS01150	COG0037	tRNA processing
GPX95_RS01170	COG3842	ATPase activity
GPX95_RS01175	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPX95_RS01180	COG1177	transmembrane transport
GPX95_RS01185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPX95_RS01190	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPX95_RS01205	COG1115	amino acid carrier protein
GPX95_RS01210	COG1280	lysine exporter protein (LysE YggA)
GPX95_RS01260	COG3501	Rhs element vgr protein
GPX95_RS01270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPX95_RS01280	COG2814	Major facilitator Superfamily
GPX95_RS01285	COG1566	PFAM secretion protein HlyD family protein
GPX95_RS01290	COG1538	Outer membrane efflux protein
GPX95_RS01300	COG0513	Belongs to the DEAD box helicase family
GPX95_RS01305	COG0840	transmembrane signaling receptor activity
GPX95_RS01315	COG0840	transmembrane signaling receptor activity
GPX95_RS01320	COG0835	chemotaxis
GPX95_RS01325	COG2201	protein-glutamate methylesterase activity
GPX95_RS01335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPX95_RS01345	COG2198	Histidine kinase
GPX95_RS01345	COG0643	Histidine kinase
GPX95_RS01365	COG2076	Multidrug Resistance protein
GPX95_RS01370	COG0477	Major facilitator Superfamily
GPX95_RS01375	COG0583	DNA-binding transcription factor activity
GPX95_RS01385	COG0095	Lipoate-protein ligase
GPX95_RS01390	COG0443	Heat shock 70 kDa protein
GPX95_RS01395	COG0402	S-adenosylhomocysteine deaminase activity
GPX95_RS01420	COG1643	Atp-dependent helicase
GPX95_RS01450	COG3706	GGDEF domain
GPX95_RS01460	COG0443	Heat shock 70 kDa protein
GPX95_RS01470	COG3706	GGDEF domain
GPX95_RS01485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPX95_RS01500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPX95_RS01505	COG0602	queuosine metabolic process
GPX95_RS01510	COG0561	phosphatase activity
GPX95_RS01520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX95_RS01525	COG4597	amino acid ABC transporter
GPX95_RS01530	COG0765	amino acid transport
GPX95_RS01535	COG1126	abc transporter atp-binding protein
GPX95_RS01540	COG0670	Belongs to the BI1 family
GPX95_RS01545	COG2920	part of a sulfur-relay system
GPX95_RS01550	COG1254	Belongs to the acylphosphatase family
GPX95_RS01560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPX95_RS01565	COG3706	GGDEF domain
GPX95_RS01580	COG3437	response regulator, receiver
GPX95_RS01585	COG0625	glutathione transferase activity
GPX95_RS01595	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPX95_RS01605	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPX95_RS01635	COG0372	Belongs to the citrate synthase family
GPX95_RS01640	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPX95_RS01645	COG2186	Transcriptional regulator
GPX95_RS01670	COG1566	PFAM secretion protein HlyD family protein
GPX95_RS01690	COG1129	ABC transporter
GPX95_RS01715	COG0745	RESPONSE REGULATOR receiver
GPX95_RS01720	COG5002	protein histidine kinase activity
GPX95_RS01725	COG3713	MltA-interacting MipA family protein
GPX95_RS01730	COG2990	Protein conserved in bacteria
GPX95_RS01740	COG4191	Histidine kinase
GPX95_RS01740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX95_RS01745	COG0471	metal ion transport
GPX95_RS01755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPX95_RS01775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX95_RS01785	COG3768	UPF0283 membrane protein
GPX95_RS01790	COG3106	COG3106 Predicted ATPase
GPX95_RS01805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPX95_RS01810	COG0494	nUDIX hydrolase
GPX95_RS01815	COG0814	amino acid
GPX95_RS01820	COG1760	l-serine dehydratase
GPX95_RS01825	COG0720	synthase
GPX95_RS01830	COG0840	transmembrane signaling receptor activity
GPX95_RS01835	COG0017	Asparaginyl-tRNA synthetase
GPX95_RS01840	COG0351	phosphomethylpyrimidine kinase
GPX95_RS01845	COG0110	maltose O-acetyltransferase activity
GPX95_RS01850	COG1448	Aminotransferase
GPX95_RS01865	COG0840	transmembrane signaling receptor activity
GPX95_RS01870	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPX95_RS01875	COG2943	transferase activity, transferring hexosyl groups
GPX95_RS01885	COG3394	polysaccharide catabolic process
GPX95_RS01890	COG1486	melibiose metabolic process
GPX95_RS01895	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPX95_RS01905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPX95_RS01910	COG0726	polysaccharide deacetylase
GPX95_RS01920	COG1846	Transcriptional regulator
GPX95_RS01945	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPX95_RS01960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPX95_RS01995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPX95_RS02020	COG1278	Cold shock
GPX95_RS02030	COG4235	cytochrome complex assembly
GPX95_RS02030	COG3088	subunit of a heme lyase
GPX95_RS02040	COG1138	Cytochrome C-type biogenesis protein
GPX95_RS02045	COG3301	Polysulphide reductase, NrfD
GPX95_RS02050	COG0437	4 iron, 4 sulfur cluster binding
GPX95_RS02055	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPX95_RS02075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPX95_RS02080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPX95_RS02130	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPX95_RS02135	COG4139	cobalamin transport
GPX95_RS02140	COG2988	succinylglutamate desuccinylase activity
GPX95_RS02160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPX95_RS02165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPX95_RS02175	COG2925	Exonuclease
GPX95_RS02185	COG1346	cytolysis
GPX95_RS02190	COG0295	cytidine deaminase activity
GPX95_RS02205	COG0500	methyltransferase
GPX95_RS02215	COG0776	regulation of translation
GPX95_RS02220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPX95_RS02220	COG0072	phenylalanine-tRNA ligase activity
GPX95_RS02225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPX95_RS02265	COG0322	excinuclease ABC activity
GPX95_RS02270	COG2197	response regulator
GPX95_RS02275	COG0417	DNA replication proofreading
GPX95_RS02280	COG5001	Diguanylate cyclase
GPX95_RS02290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPX95_RS02310	COG1228	amidohydrolase
GPX95_RS02315	COG0010	Belongs to the arginase family
GPX95_RS02320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPX95_RS02325	COG2986	histidine ammonia-lyase
GPX95_RS02360	COG2885	chlorophyll binding
GPX95_RS02380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPX95_RS02390	COG0281	malic enzyme
GPX95_RS02400	COG2949	membrane
GPX95_RS02420	COG0492	ferredoxin-NADP+ reductase activity
GPX95_RS02425	COG4988	ABC transporter
GPX95_RS02430	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPX95_RS02435	COG1187	pseudouridine synthase activity
GPX95_RS02440	COG0009	L-threonylcarbamoyladenylate synthase
GPX95_RS02445	COG0613	PHP domain protein
GPX95_RS02455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPX95_RS02460	COG0512	Glutamine amidotransferase of anthranilate synthase
GPX95_RS02465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPX95_RS02470	COG0134	indole-3-glycerol-phosphate synthase activity
GPX95_RS02470	COG0135	phosphoribosylanthranilate isomerase activity
GPX95_RS02475	COG0133	tryptophan synthase activity
GPX95_RS02480	COG0159	tryptophan synthase activity
GPX95_RS02485	COG1301	dicarboxylic acid transport
GPX95_RS02490	COG1435	thymidine kinase activity
GPX95_RS02495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPX95_RS02500	COG1801	Protein of unknown function DUF72
GPX95_RS02505	COG4106	trans-aconitate 2-methyltransferase activity
GPX95_RS02510	COG0500	methyltransferase
GPX95_RS02515	COG4067	protein conserved in archaea
GPX95_RS02515	COG0189	ligase activity
GPX95_RS02530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPX95_RS02540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX95_RS02540	COG4191	Histidine kinase
GPX95_RS02555	COG3070	regulator of competence-specific genes
GPX95_RS02565	COG2431	L-lysine efflux transmembrane transporter activity
GPX95_RS02575	COG0076	glutamate decarboxylase activity
GPX95_RS02580	COG1737	Transcriptional regulator
GPX95_RS02585	COG1012	belongs to the aldehyde dehydrogenase family
GPX95_RS02585	COG1454	alcohol dehydrogenase
GPX95_RS02590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPX95_RS02600	COG0542	response to heat
GPX95_RS02605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPX95_RS02610	COG1278	Cold shock
GPX95_RS02620	COG1187	pseudouridine synthase activity
GPX95_RS02625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPX95_RS02625	COG0140	phosphoribosyl-ATP diphosphatase activity
GPX95_RS02630	COG0107	imidazoleglycerol-phosphate synthase activity
GPX95_RS02635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPX95_RS02640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPX95_RS02645	COG0131	Imidazoleglycerol-phosphate dehydratase
GPX95_RS02645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPX95_RS02650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPX95_RS02655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPX95_RS02660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPX95_RS02670	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPX95_RS02675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX95_RS02680	COG0482	sulfurtransferase activity
GPX95_RS02685	COG2915	High frequency lysogenization protein hflD homolog
GPX95_RS02690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPX95_RS02700	COG2268	Band 7 protein
GPX95_RS02710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPX95_RS02725	COG0300	oxidoreductase activity
GPX95_RS02735	COG0501	Belongs to the peptidase M48B family
GPX95_RS02745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPX95_RS02750	COG2226	methyltransferase
GPX95_RS02755	COG0156	8-amino-7-oxononanoate synthase activity
GPX95_RS02760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPX95_RS02765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPX95_RS02770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPX95_RS02775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPX95_RS02780	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPX95_RS02785	COG0653	protein targeting
GPX95_RS02790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPX95_RS02795	COG3706	GGDEF domain
GPX95_RS02805	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPX95_RS02815	COG4628	conserved protein (DUF2132)
GPX95_RS02820	COG3092	negative regulation of chromosome organization
GPX95_RS02825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPX95_RS02830	COG0857	belongs to the CobB CobQ family
GPX95_RS02830	COG0280	phosphate acetyltransferase
GPX95_RS02835	COG0435	Glutathione S-transferase
GPX95_RS02845	COG0444	Belongs to the ABC transporter superfamily
GPX95_RS02855	COG0601	transmembrane transport
GPX95_RS02870	COG4191	Histidine kinase
GPX95_RS02875	COG2204	response regulator
GPX95_RS02880	COG5001	Diguanylate cyclase
GPX95_RS02880	COG3300	MHYT domain
GPX95_RS02885	COG4191	Histidine kinase
GPX95_RS02890	COG5002	protein histidine kinase activity
GPX95_RS02900	COG2201	protein-glutamate methylesterase activity
GPX95_RS02915	COG0009	L-threonylcarbamoyladenylate synthase
GPX95_RS02935	COG1881	PFAM PEBP family protein
GPX95_RS02960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS02965	COG3716	PTS system mannose fructose sorbose family IID component
GPX95_RS02975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX95_RS02980	COG2222	sugar isomerase
GPX95_RS02990	COG1349	DNA-binding transcription factor activity
GPX95_RS02995	COG1349	DNA-binding transcription factor activity
GPX95_RS03010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPX95_RS03015	COG0640	Transcriptional regulator
GPX95_RS03025	COG5001	Diguanylate cyclase
GPX95_RS03025	COG3300	MHYT domain
GPX95_RS03045	COG1946	Acyl-CoA thioesterase
GPX95_RS03050	COG1522	sequence-specific DNA binding
GPX95_RS03060	COG0616	signal peptide processing
GPX95_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
GPX95_RS03080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPX95_RS03085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPX95_RS03095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPX95_RS03100	COG2832	Protein of unknown function (DUF454)
GPX95_RS03110	COG0745	RESPONSE REGULATOR receiver
GPX95_RS03115	COG0583	DNA-binding transcription factor activity
GPX95_RS03120	COG0778	Nitroreductase
GPX95_RS03125	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPX95_RS03125	COG1024	Enoyl-CoA hydratase
GPX95_RS03130	COG0183	Belongs to the thiolase family
GPX95_RS03145	COG2067	long-chain fatty acid transport protein
GPX95_RS03150	COG2067	long-chain fatty acid transport protein
GPX95_RS03155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPX95_RS03160	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPX95_RS03170	COG0572	uridine kinase
GPX95_RS03175	COG0489	protein tyrosine kinase activity
GPX95_RS03180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPX95_RS03180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPX95_RS03190	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPX95_RS03200	COG0516	GMP reductase activity
GPX95_RS03200	COG0517	IMP dehydrogenase activity
GPX95_RS03205	COG2199	diguanylate cyclase activity
GPX95_RS03210	COG0314	molybdopterin synthase activity
GPX95_RS03215	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPX95_RS03220	COG0315	cyclic pyranopterin monophosphate synthase activity
GPX95_RS03225	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPX95_RS03230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPX95_RS03235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPX95_RS03240	COG2198	Histidine kinase
GPX95_RS03250	COG0556	nucleotide-excision repair
GPX95_RS03260	COG4657	Part of a membrane complex involved in electron transport
GPX95_RS03265	COG2878	Part of a membrane complex involved in electron transport
GPX95_RS03270	COG4656	Part of a membrane complex involved in electron transport
GPX95_RS03275	COG4658	electron transport chain
GPX95_RS03280	COG4659	FMN binding
GPX95_RS03285	COG4660	Part of a membrane complex involved in electron transport
GPX95_RS03290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPX95_RS03295	COG0346	lactoylglutathione lyase activity
GPX95_RS03305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPX95_RS03310	COG2056	Na+-H+ antiporter family
GPX95_RS03315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPX95_RS03320	COG1286	toxin biosynthetic process
GPX95_RS03325	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPX95_RS03330	COG0285	dihydrofolate synthase activity
GPX95_RS03340	COG0101	tRNA pseudouridine synthase activity
GPX95_RS03350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPX95_RS03355	COG1263	PTS System
GPX95_RS03355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX95_RS03355	COG2190	(PTS) system
GPX95_RS03360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPX95_RS03365	COG1846	Transcriptional regulator
GPX95_RS03365	COG1940	carbohydrate kinase activity
GPX95_RS03375	COG0367	asparagine synthase
GPX95_RS03380	COG0250	Participates in transcription elongation, termination and antitermination
GPX95_RS03385	COG3104	oligopeptide transport
GPX95_RS03390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPX95_RS03395	COG0563	adenylate kinase activity
GPX95_RS03400	COG0326	Molecular chaperone. Has ATPase activity
GPX95_RS03405	COG3710	Transcriptional regulator
GPX95_RS03420	COG0622	Phosphoesterase
GPX95_RS03430	COG0300	oxidoreductase activity
GPX95_RS03440	COG3118	belongs to the thioredoxin family
GPX95_RS03445	COG0330	HflC and HflK could
GPX95_RS03450	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPX95_RS03455	COG0789	Transcriptional regulator
GPX95_RS03470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPX95_RS03475	COG3115	cell septum assembly
GPX95_RS03480	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPX95_RS03485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPX95_RS03495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS03505	COG2190	(PTS) system
GPX95_RS03510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPX95_RS03515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPX95_RS03520	COG1702	phosphate starvation-inducible protein PhoH
GPX95_RS03525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPX95_RS03530	COG4535	Mg2 and Co2 transporter CorC
GPX95_RS03535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPX95_RS03540	COG2888	peptidyl-tyrosine sulfation
GPX95_RS03545	COG0495	leucyl-tRNA aminoacylation
GPX95_RS03550	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPX95_RS03555	COG1466	dna polymerase III delta subunit
GPX95_RS03560	COG0799	negative regulation of ribosome biogenesis
GPX95_RS03565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPX95_RS03570	COG0768	penicillin binding
GPX95_RS03585	COG1686	Belongs to the peptidase S11 family
GPX95_RS03590	COG2921	Belongs to the UPF0250 family
GPX95_RS03595	COG0321	lipoyl(octanoyl) transferase activity
GPX95_RS03600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPX95_RS03610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPX95_RS03635	COG1596	polysaccharide export
GPX95_RS03645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPX95_RS03675	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPX95_RS03685	COG0438	transferase activity, transferring glycosyl groups
GPX95_RS03685	COG0297	glycogen (starch) synthase activity
GPX95_RS03695	COG0438	transferase activity, transferring glycosyl groups
GPX95_RS03725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPX95_RS03730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPX95_RS03735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPX95_RS03745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPX95_RS03775	COG1263	PTS System
GPX95_RS03775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX95_RS03780	COG1609	Transcriptional regulator
GPX95_RS03785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPX95_RS03790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPX95_RS03795	COG2011	ABC-type metal ion transport system permease component
GPX95_RS03800	COG1464	Belongs to the NlpA lipoprotein family
GPX95_RS03805	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPX95_RS03815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPX95_RS03815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPX95_RS03825	COG3706	GGDEF domain
GPX95_RS03830	COG1611	Belongs to the LOG family
GPX95_RS03835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPX95_RS03840	COG2363	Small membrane protein
GPX95_RS03845	COG0583	DNA-binding transcription factor activity
GPX95_RS03850	COG0301	tRNA thio-modification
GPX95_RS03850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPX95_RS03860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPX95_RS03865	COG1722	exodeoxyribonuclease VII activity
GPX95_RS03870	COG0142	geranyltranstransferase activity
GPX95_RS03875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPX95_RS03880	COG0564	pseudouridine synthase activity
GPX95_RS03910	COG1671	Belongs to the UPF0178 family
GPX95_RS03915	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPX95_RS03920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPX95_RS03925	COG0254	rRNA binding
GPX95_RS03930	COG1720	tRNA m6t6A37 methyltransferase activity
GPX95_RS03935	COG0442	prolyl-tRNA aminoacylation
GPX95_RS03955	COG0047	phosphoribosylformylglycinamidine synthase activity
GPX95_RS03955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPX95_RS03965	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPX95_RS03970	COG0590	tRNA wobble adenosine to inosine editing
GPX95_RS03975	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPX95_RS04005	COG0484	heat shock protein binding
GPX95_RS04010	COG0443	Heat shock 70 kDa protein
GPX95_RS04015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPX95_RS04020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPX95_RS04025	COG0497	DNA recombination
GPX95_RS04030	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPX95_RS04035	COG2914	Belongs to the UPF0125 (RnfH) family
GPX95_RS04040	COG2867	negative regulation of translational initiation
GPX95_RS04045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPX95_RS04055	COG1061	Type III restriction enzyme res subunit
GPX95_RS04070	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPX95_RS04075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPX95_RS04080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPX95_RS04090	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPX95_RS04095	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPX95_RS04100	COG3051	citrate lyase alpha subunit
GPX95_RS04105	COG2301	Belongs to the HpcH HpaI aldolase family
GPX95_RS04110	COG3052	prosthetic group binding
GPX95_RS04115	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPX95_RS04125	COG3630	sodium ion export across plasma membrane
GPX95_RS04130	COG5016	pyruvate
GPX95_RS04130	COG0511	ligase activity, forming carbon-carbon bonds
GPX95_RS04135	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPX95_RS04145	COG4565	transcriptional regulatory protein
GPX95_RS04160	COG0583	DNA-binding transcription factor activity
GPX95_RS04165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPX95_RS04170	COG1115	amino acid carrier protein
GPX95_RS04175	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPX95_RS04180	COG0583	DNA-binding transcription factor activity
GPX95_RS04185	COG1584	GPR1 FUN34 yaaH family protein
GPX95_RS04195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPX95_RS04195	COG0519	Catalyzes the synthesis of GMP from XMP
GPX95_RS04200	COG0516	GMP reductase activity
GPX95_RS04200	COG0517	IMP dehydrogenase activity
GPX95_RS04205	COG1570	exodeoxyribonuclease VII activity
GPX95_RS04220	COG1160	GTP binding
GPX95_RS04225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPX95_RS04230	COG2976	Protein conserved in bacteria
GPX95_RS04235	COG0124	histidyl-tRNA synthetase
GPX95_RS04240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPX95_RS04245	COG1426	Protein conserved in bacteria
GPX95_RS04250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPX95_RS04255	COG0105	UTP biosynthetic process
GPX95_RS04260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPX95_RS04265	COG2975	iron-sulfur cluster assembly
GPX95_RS04270	COG0633	Ferredoxin
GPX95_RS04280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPX95_RS04290	COG0822	iron-sulfur transferase activity
GPX95_RS04300	COG1959	2 iron, 2 sulfur cluster binding
GPX95_RS04305	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPX95_RS04310	COG0483	inositol monophosphate 1-phosphatase activity
GPX95_RS04315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPX95_RS04320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPX95_RS04325	COG1862	Preprotein translocase
GPX95_RS04330	COG0343	queuine tRNA-ribosyltransferase activity
GPX95_RS04340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPX95_RS04345	COG0517	IMP dehydrogenase activity
GPX95_RS04355	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPX95_RS04360	COG0583	DNA-binding transcription factor activity
GPX95_RS04365	COG0450	alkyl hydroperoxide reductase
GPX95_RS04370	COG3142	Participates in the control of copper homeostasis
GPX95_RS04390	COG0581	inorganic phosphate transmembrane transporter activity
GPX95_RS04395	COG0573	inorganic phosphate transmembrane transporter activity
GPX95_RS04400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPX95_RS04405	COG0248	Ppx GppA phosphatase
GPX95_RS04415	COG5002	protein histidine kinase activity
GPX95_RS04420	COG0745	RESPONSE REGULATOR receiver
GPX95_RS04425	COG2974	May be involved in recombination
GPX95_RS04435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPX95_RS04480	COG0542	response to heat
GPX95_RS04490	COG0564	pseudouridine synthase activity
GPX95_RS04495	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPX95_RS04500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPX95_RS04505	COG1605	Chorismate mutase
GPX95_RS04505	COG0077	Prephenate dehydratase
GPX95_RS04510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPX95_RS04515	COG5001	Diguanylate cyclase
GPX95_RS04520	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPX95_RS04525	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPX95_RS04535	COG0488	(ABC) transporter
GPX95_RS04545	COG0287	Prephenate dehydrogenase
GPX95_RS04545	COG1605	Chorismate mutase
GPX95_RS04550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPX95_RS04555	COG3275	phosphorelay sensor kinase activity
GPX95_RS04560	COG3279	Response regulator of the LytR AlgR family
GPX95_RS04570	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPX95_RS04575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPX95_RS04590	COG1966	Carbon starvation protein
GPX95_RS04595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPX95_RS04600	COG1047	Peptidyl-prolyl cis-trans
GPX95_RS04605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPX95_RS04615	COG0196	riboflavin kinase activity
GPX95_RS04620	COG0728	peptidoglycan biosynthetic process
GPX95_RS04625	COG0268	Binds directly to 16S ribosomal RNA
GPX95_RS04630	COG0640	Transcriptional regulator
GPX95_RS04635	COG0583	DNA-binding transcription factor activity
GPX95_RS04640	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPX95_RS04645	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPX95_RS04650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPX95_RS04655	COG0730	response to heat
GPX95_RS04665	COG0494	nUDIX hydrolase
GPX95_RS04670	COG3066	DNA modification
GPX95_RS04675	COG0667	Aldo Keto reductase
GPX95_RS04685	COG2204	response regulator
GPX95_RS04690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPX95_RS04705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPX95_RS04715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPX95_RS04735	COG3153	acetyltransferase
GPX95_RS04775	COG1185	polyribonucleotide nucleotidyltransferase activity
GPX95_RS04780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPX95_RS04785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPX95_RS04790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPX95_RS04795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPX95_RS04800	COG0195	Participates in both transcription termination and antitermination
GPX95_RS04805	COG0779	Required for maturation of 30S ribosomal subunits
GPX95_RS04820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPX95_RS04825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPX95_RS04830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPX95_RS04835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPX95_RS04840	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPX95_RS04845	COG1534	Rna-binding protein
GPX95_RS04850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPX95_RS04855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPX95_RS04860	COG2027	D-alanyl-D-alanine carboxypeptidase
GPX95_RS04865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPX95_RS04870	COG0739	heme binding
GPX95_RS04875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPX95_RS04885	COG0316	Belongs to the HesB IscA family
GPX95_RS04890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPX95_RS04895	COG0628	permease
GPX95_RS04900	COG2813	Specifically methylates the guanine in position
GPX95_RS04910	COG0747	negative chemotaxis
GPX95_RS04920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPX95_RS04925	COG0444	Belongs to the ABC transporter superfamily
GPX95_RS04930	COG4608	Belongs to the ABC transporter superfamily
GPX95_RS04940	COG2971	BadF BadG BcrA BcrD
GPX95_RS04960	COG3842	ATPase activity
GPX95_RS04970	COG1840	ABC-type Fe3 transport system, periplasmic component
GPX95_RS04975	COG0004	ammonium transporteR
GPX95_RS04980	COG0347	Belongs to the P(II) protein family
GPX95_RS04985	COG3112	Uncharacterised protein family (UPF0231)
GPX95_RS05000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPX95_RS05005	COG1643	Atp-dependent helicase
GPX95_RS05015	COG1489	DNA binding
GPX95_RS05020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPX95_RS05025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPX95_RS05035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPX95_RS05040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPX95_RS05045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPX95_RS05050	COG0842	Transport permease protein
GPX95_RS05055	COG1131	(ABC) transporter
GPX95_RS05060	COG0659	secondary active sulfate transmembrane transporter activity
GPX95_RS05065	COG0288	reversible hydration of carbon dioxide
GPX95_RS05080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPX95_RS05085	COG3107	peptidoglycan biosynthetic process
GPX95_RS05090	COG0792	nuclease activity
GPX95_RS05095	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPX95_RS05100	COG2823	Periplasmic or secreted lipoprotein
GPX95_RS05105	COG2969	positive regulation of protein catabolic process
GPX95_RS05110	COG0625	glutathione transferase activity
GPX95_RS05115	COG2857	Cytochrome c1
GPX95_RS05120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPX95_RS05125	COG0723	plastoquinol--plastocyanin reductase activity
GPX95_RS05130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPX95_RS05135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPX95_RS05150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPX95_RS05155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPX95_RS05160	COG0335	large ribosomal subunit rRNA binding
GPX95_RS05165	COG0336	Belongs to the RNA methyltransferase TrmD family
GPX95_RS05170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPX95_RS05175	COG0228	four-way junction DNA binding
GPX95_RS05180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPX95_RS05185	COG4137	Cytochrome C assembly protein
GPX95_RS05190	COG4536	flavin adenine dinucleotide binding
GPX95_RS05195	COG1854	S-ribosylhomocysteine lyase activity
GPX95_RS05200	COG2918	glutathione biosynthetic process
GPX95_RS05205	COG0612	Peptidase, M16
GPX95_RS05210	COG1238	metal cluster binding
GPX95_RS05220	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPX95_RS05225	COG5016	pyruvate
GPX95_RS05225	COG0511	ligase activity, forming carbon-carbon bonds
GPX95_RS05230	COG3630	sodium ion export across plasma membrane
GPX95_RS05275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPX95_RS05280	COG0527	aspartate kinase activity
GPX95_RS05285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPX95_RS05290	COG2137	regulation of response to DNA damage stimulus
GPX95_RS05295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPX95_RS05300	COG1546	Belongs to the CinA family
GPX95_RS05310	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPX95_RS05315	COG4208	sulfate ABC transporter
GPX95_RS05325	COG4150	thiosulfate binding
GPX95_RS05335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPX95_RS05340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPX95_RS05345	COG4942	peptidase
GPX95_RS05345	COG1388	LysM domain
GPX95_RS05350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPX95_RS05355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPX95_RS05360	COG0585	pseudouridine synthase activity
GPX95_RS05365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPX95_RS05370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPX95_RS05375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPX95_RS05380	COG1968	undecaprenyl-diphosphatase activity
GPX95_RS05385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPX95_RS05390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPX95_RS05395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPX95_RS05405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPX95_RS05410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPX95_RS05415	COG1610	YqeY-like protein
GPX95_RS05420	COG0358	DNA primase activity
GPX95_RS05425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPX95_RS05445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPX95_RS05450	COG1349	DNA-binding transcription factor activity
GPX95_RS05455	COG0469	pyruvate kinase activity
GPX95_RS05465	COG0583	DNA-binding transcription factor activity
GPX95_RS05475	COG0668	transmembrane transport
GPX95_RS05480	COG0191	fructose-bisphosphate aldolase activity
GPX95_RS05485	COG0126	phosphoglycerate kinase activity
GPX95_RS05490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPX95_RS05495	COG4771	TonB-dependent receptor
GPX95_RS05500	COG0583	DNA-binding transcription factor activity
GPX95_RS05510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPX95_RS05515	COG3091	SprT-like family
GPX95_RS05520	COG2356	endonuclease I
GPX95_RS05525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPX95_RS05530	COG0189	ligase activity
GPX95_RS05535	COG1678	Uncharacterized ACR, COG1678
GPX95_RS05540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPX95_RS05545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPX95_RS05565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPX95_RS05570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPX95_RS05575	COG0762	integral membrane protein
GPX95_RS05590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPX95_RS05595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPX95_RS05600	COG2066	Belongs to the glutaminase family
GPX95_RS05605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPX95_RS05610	COG1194	a g-specific adenine glycosylase
GPX95_RS05615	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPX95_RS05620	COG0741	lytic transglycosylase activity
GPX95_RS05675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPX95_RS05680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPX95_RS05685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPX95_RS05690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPX95_RS05695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPX95_RS05700	COG2967	ApaG domain
GPX95_RS05705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPX95_RS05715	COG3610	response to peptide
GPX95_RS05720	COG3610	response to peptide
GPX95_RS05725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPX95_RS05730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPX95_RS05735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPX95_RS05740	COG0142	geranyltranstransferase activity
GPX95_RS05750	COG0039	L-malate dehydrogenase activity
GPX95_RS05755	COG1438	arginine binding
GPX95_RS05770	COG0589	response to stress
GPX95_RS05790	COG2235	arginine
GPX95_RS05795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPX95_RS05805	COG0312	modulator of DNA gyrase
GPX95_RS05810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPX95_RS05815	COG3164	Protein of unknown function
GPX95_RS05820	COG1530	ribonuclease E activity
GPX95_RS05825	COG0424	maF-like protein
GPX95_RS05830	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPX95_RS05835	COG1792	Involved in formation and maintenance of cell shape
GPX95_RS05840	COG1077	Cell shape determining protein MreB Mrl
GPX95_RS05885	COG1459	type II secretion system
GPX95_RS05890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPX95_RS05900	COG3409	Peptidoglycan-binding domain 1 protein
GPX95_RS05900	COG3267	Type II secretory pathway component ExeA
GPX95_RS05925	COG2200	EAL domain
GPX95_RS05925	COG2199	diguanylate cyclase activity
GPX95_RS05945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPX95_RS05955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPX95_RS05960	COG0527	aspartate kinase activity
GPX95_RS05965	COG1410	methionine synthase
GPX95_RS05965	COG0646	methionine synthase
GPX95_RS06035	COG0175	sulfate reduction
GPX95_RS06040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPX95_RS06045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPX95_RS06070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPX95_RS06075	COG0735	belongs to the Fur family
GPX95_RS06090	COG0166	Belongs to the GPI family
GPX95_RS06095	COG0432	Pfam Uncharacterised protein family UPF0047
GPX95_RS06100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPX95_RS06105	COG0305	Participates in initiation and elongation during chromosome replication
GPX95_RS06115	COG0359	binds to the 23S rRNA
GPX95_RS06120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPX95_RS06125	COG2965	DNA replication, synthesis of RNA primer
GPX95_RS06130	COG0360	Binds together with S18 to 16S ribosomal RNA
GPX95_RS06140	COG2906	2 iron, 2 sulfur cluster binding
GPX95_RS06145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPX95_RS06150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPX95_RS06155	COG0049	tRNA binding
GPX95_RS06160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPX95_RS06170	COG2923	Belongs to the DsrF TusC family
GPX95_RS06175	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPX95_RS06180	COG2964	Protein conserved in bacteria
GPX95_RS06185	COG0545	Peptidyl-prolyl cis-trans isomerase
GPX95_RS06195	COG2900	Belongs to the SlyX family
GPX95_RS06200	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPX95_RS06205	COG0330	HflC and HflK could
GPX95_RS06210	COG0330	HflC and HflK could
GPX95_RS06215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPX95_RS06220	COG1923	regulation of RNA biosynthetic process
GPX95_RS06225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPX95_RS06230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPX95_RS06240	COG0802	atpase or kinase
GPX95_RS06245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPX95_RS06295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPX95_RS06300	COG1162	GTPase activity
GPX95_RS06305	COG0688	phosphatidylethanolamine metabolic process
GPX95_RS06310	COG0471	metal ion transport
GPX95_RS06320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPX95_RS06325	COG4942	peptidase
GPX95_RS06340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPX95_RS06345	COG2816	NAD+ diphosphatase activity
GPX95_RS06350	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPX95_RS06355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPX95_RS06360	COG0085	RNA polymerase activity
GPX95_RS06365	COG0222	ribosome binding
GPX95_RS06370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPX95_RS06375	COG0081	regulation of translation
GPX95_RS06380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPX95_RS06385	COG0250	Participates in transcription elongation, termination and antitermination
GPX95_RS06390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPX95_RS06395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPX95_RS06420	COG1072	(Pantothenic acid kinase))
GPX95_RS06430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPX95_RS06440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPX95_RS06480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPX95_RS06490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPX95_RS06495	COG3118	belongs to the thioredoxin family
GPX95_RS06500	COG0513	Belongs to the DEAD box helicase family
GPX95_RS06505	COG0248	Ppx GppA phosphatase
GPX95_RS06515	COG2814	Major facilitator Superfamily
GPX95_RS06530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPX95_RS06535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPX95_RS06540	COG0511	ligase activity, forming carbon-carbon bonds
GPX95_RS06545	COG0439	Biotin carboxylase
GPX95_RS06555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPX95_RS06560	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPX95_RS06565	COG1609	Transcriptional regulator
GPX95_RS06570	COG0129	dihydroxy-acid dehydratase activity
GPX95_RS06575	COG3265	gluconokinase activity
GPX95_RS06585	COG0800	Aldolase
GPX95_RS06590	COG0840	transmembrane signaling receptor activity
GPX95_RS06595	COG1982	Orn Lys Arg decarboxylase major
GPX95_RS06600	COG0531	amino acid
GPX95_RS06605	COG3710	Transcriptional regulator
GPX95_RS06610	COG0789	Transcriptional regulator
GPX95_RS06620	COG0138	bifunctional purine biosynthesis protein purh
GPX95_RS06625	COG0151	Belongs to the GarS family
GPX95_RS06635	COG0776	regulation of translation
GPX95_RS06640	COG1253	flavin adenine dinucleotide binding
GPX95_RS06645	COG3068	Protein conserved in bacteria
GPX95_RS06655	COG1573	uracil-dna glycosylase
GPX95_RS06660	COG0668	transmembrane transport
GPX95_RS06675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPX95_RS06685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPX95_RS06750	COG2089	acid synthase
GPX95_RS06760	COG1083	cytidylyl-transferase
GPX95_RS06765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPX95_RS06770	COG1086	Polysaccharide biosynthesis protein
GPX95_RS06775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPX95_RS06785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPX95_RS06795	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GPX95_RS06800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPX95_RS06835	COG1519	Transferase
GPX95_RS06860	COG3642	lipopolysaccharide core region biosynthetic process
GPX95_RS06865	COG0859	PFAM glycosyl transferase family 9
GPX95_RS06870	COG0463	Glycosyl transferase, family 2
GPX95_RS06875	COG0859	PFAM glycosyl transferase family 9
GPX95_RS06880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPX95_RS06885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPX95_RS06895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPX95_RS06900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPX95_RS06915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPX95_RS06925	COG1309	transcriptional regulator
GPX95_RS06935	COG1560	Kdo2-lipid A biosynthetic process
GPX95_RS06940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPX95_RS06945	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPX95_RS06950	COG1561	YicC-like family, N-terminal region
GPX95_RS06975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPX95_RS07020	COG1120	ATPase activity
GPX95_RS07025	COG4774	siderophore transport
GPX95_RS07030	COG1132	(ABC) transporter
GPX95_RS07045	COG0514	ATP-dependent DNA helicase (RecQ)
GPX95_RS07050	COG2962	Rard protein
GPX95_RS07070	COG0210	DNA helicase
GPX95_RS07080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPX95_RS07085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPX95_RS07100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPX95_RS07110	COG0747	negative chemotaxis
GPX95_RS07155	COG1309	transcriptional regulator
GPX95_RS07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPX95_RS07165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPX95_RS07170	COG2960	long-chain fatty acid transporting porin activity
GPX95_RS07175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPX95_RS07180	COG0583	DNA-binding transcription factor activity
GPX95_RS07250	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPX95_RS07255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPX95_RS07260	COG1739	Uncharacterized protein family UPF0029
GPX95_RS07265	COG1024	Enoyl-CoA hydratase
GPX95_RS07265	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPX95_RS07270	COG0183	Belongs to the thiolase family
GPX95_RS07275	COG0583	DNA-binding transcription factor activity
GPX95_RS07280	COG2814	Major facilitator Superfamily
GPX95_RS07290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPX95_RS07295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPX95_RS07300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPX95_RS07305	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPX95_RS07310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPX95_RS07315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPX95_RS07325	COG0356	it plays a direct role in the translocation of protons across the membrane
GPX95_RS07330	COG3312	ion transport
GPX95_RS07340	COG1192	Involved in chromosome partitioning
GPX95_RS07345	COG0357	Ribosomal RNA small subunit methyltransferase G
GPX95_RS07350	COG0445	tRNA wobble uridine modification
GPX95_RS07355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPX95_RS07360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPX95_RS07365	COG0706	membrane insertase activity
GPX95_RS07370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPX95_RS07375	COG0594	ribonuclease P activity
GPX95_RS07380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPX95_RS07385	COG1126	abc transporter atp-binding protein
GPX95_RS07400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPX95_RS07405	COG0592	DNA-directed DNA polymerase activity
GPX95_RS07410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPX95_RS07415	COG0187	DNA topoisomerase II activity
GPX95_RS07430	COG0071	Belongs to the small heat shock protein (HSP20) family
GPX95_RS07435	COG3977	Valine--pyruvate aminotransferase
GPX95_RS07440	COG0751	glycine-tRNA ligase activity
GPX95_RS07445	COG0752	glycyl-tRNA synthetase alpha subunit
GPX95_RS07450	COG2119	membrane
GPX95_RS07460	COG0425	Belongs to the sulfur carrier protein TusA family
GPX95_RS07475	COG0604	alcohol dehydrogenase
GPX95_RS07485	COG0129	dihydroxy-acid dehydratase activity
GPX95_RS07490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPX95_RS07505	COG0606	chelatase, subunit chli
GPX95_RS07510	COG0204	Acyl-transferase
GPX95_RS07515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPX95_RS07520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPX95_RS07530	COG3084	Protein conserved in bacteria
GPX95_RS07540	COG4326	sporulation control protein
GPX95_RS07545	COG1272	protein, Hemolysin III
GPX95_RS07560	COG0569	domain protein
GPX95_RS07565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPX95_RS07565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPX95_RS07575	COG0242	peptide deformylase activity
GPX95_RS07580	COG1652	LysM domain
GPX95_RS07585	COG0758	DNA mediated transformation
GPX95_RS07590	COG2922	Belongs to the Smg family
GPX95_RS07595	COG0551	DNA topoisomerase type I activity
GPX95_RS07600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPX95_RS07605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPX95_RS07610	COG0009	L-threonylcarbamoyladenylate synthase
GPX95_RS07620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPX95_RS07630	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPX95_RS07670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPX95_RS07675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPX95_RS07685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPX95_RS07690	COG2104	thiamine diphosphate biosynthetic process
GPX95_RS07695	COG2022	thiamine diphosphate biosynthetic process
GPX95_RS07700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPX95_RS07705	COG0006	proline dipeptidase activity
GPX95_RS07725	COG1522	sequence-specific DNA binding
GPX95_RS07730	COG5002	protein histidine kinase activity
GPX95_RS07730	COG5001	Diguanylate cyclase
GPX95_RS07735	COG0742	ribosomal rna small subunit methyltransferase
GPX95_RS07745	COG0697	spore germination
GPX95_RS07750	COG0589	response to stress
GPX95_RS07760	COG1528	Iron-storage protein
GPX95_RS07770	COG2081	HI0933 family
GPX95_RS07805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPX95_RS07830	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPX95_RS07845	COG0840	transmembrane signaling receptor activity
GPX95_RS07855	COG1322	Protein conserved in bacteria
GPX95_RS07860	COG2226	methyltransferase
GPX95_RS07870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPX95_RS07875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPX95_RS07880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPX95_RS07885	COG0805	protein transport
GPX95_RS07890	COG0534	Mate efflux family protein
GPX95_RS07900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPX95_RS07905	COG2937	Belongs to the GPAT DAPAT family
GPX95_RS07915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPX95_RS07920	COG3161	chorismate lyase activity
GPX95_RS07930	COG1580	Controls the rotational direction of flagella during chemotaxis
GPX95_RS07940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPX95_RS07945	COG0084	hydrolase, TatD family'
GPX95_RS07960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPX95_RS07960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPX95_RS07965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPX95_RS07980	COG3078	GTPase activator activity
GPX95_RS07990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPX95_RS07995	COG3071	HemY protein
GPX95_RS08000	COG2959	enzyme of heme biosynthesis
GPX95_RS08005	COG1587	Uroporphyrinogen-III synthase
GPX95_RS08010	COG0181	hydroxymethylbilane synthase activity
GPX95_RS08015	COG3072	Adenylate cyclase
GPX95_RS08020	COG1965	Belongs to the frataxin family
GPX95_RS08030	COG0019	diaminopimelate decarboxylase activity
GPX95_RS08035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPX95_RS08050	COG1011	Hydrolase
GPX95_RS08055	COG2199	diguanylate cyclase activity
GPX95_RS08055	COG2200	EAL domain
GPX95_RS08055	COG3287	FIST C domain
GPX95_RS08070	COG0561	phosphatase activity
GPX95_RS08080	COG1280	lysine exporter protein (LysE YggA)
GPX95_RS08085	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPX95_RS08090	COG0783	Belongs to the Dps family
GPX95_RS08120	COG0742	ribosomal rna small subunit methyltransferase
GPX95_RS08125	COG0552	protein localization to endoplasmic reticulum
GPX95_RS08130	COG2884	Cell division ATP-binding protein ftsE
GPX95_RS08135	COG2177	Part of the ABC transporter FtsEX involved in
GPX95_RS08140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPX95_RS08145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPX95_RS08160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPX95_RS08175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPX95_RS08245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPX95_RS08250	COG5001	Diguanylate cyclase
GPX95_RS08250	COG3300	MHYT domain
GPX95_RS08260	COG3852	Histidine kinase
GPX95_RS08270	COG0174	glutamine synthetase
GPX95_RS08280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPX95_RS08290	COG1490	D-aminoacyl-tRNA deacylase activity
GPX95_RS08295	COG0456	acetyltransferase
GPX95_RS08310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPX95_RS08315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPX95_RS08320	COG3031	protein transport across the cell outer membrane
GPX95_RS08330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPX95_RS08335	COG1459	type II secretion system
GPX95_RS08340	COG2165	general secretion pathway protein
GPX95_RS08345	COG2165	general secretion pathway protein
GPX95_RS08350	COG2165	general secretion pathway protein
GPX95_RS08355	COG4795	General secretion pathway protein
GPX95_RS08360	COG3156	type II secretion system protein K
GPX95_RS08365	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPX95_RS08370	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPX95_RS08380	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPX95_RS08385	COG0494	nUDIX hydrolase
GPX95_RS08390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPX95_RS08390	COG0316	Belongs to the HesB IscA family
GPX95_RS08395	COG1040	competence protein
GPX95_RS08400	COG0596	Alpha beta hydrolase
GPX95_RS08410	COG2183	response to ionizing radiation
GPX95_RS08415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPX95_RS08435	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPX95_RS08440	COG1472	Belongs to the glycosyl hydrolase 3 family
GPX95_RS08445	COG2199	diguanylate cyclase activity
GPX95_RS08450	COG0745	RESPONSE REGULATOR receiver
GPX95_RS08460	COG2233	PERMEase
GPX95_RS08465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPX95_RS08475	COG1758	RNA polymerase activity
GPX95_RS08480	COG0194	GDP metabolic process
GPX95_RS08485	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPX95_RS08490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPX95_RS08510	COG4232	protein-disulfide reductase activity
GPX95_RS08520	COG1027	Aspartate ammonia-lyase
GPX95_RS08530	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPX95_RS08535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPX95_RS08540	COG2205	protein histidine kinase activity
GPX95_RS08555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPX95_RS08560	COG0205	6-phosphofructokinase activity
GPX95_RS08565	COG1494	fructose-1,6-bisphosphatase
GPX95_RS08570	COG3074	FtsZ-dependent cytokinesis
GPX95_RS08575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPX95_RS08580	COG0460	homoserine dehydrogenase
GPX95_RS08580	COG0527	aspartate kinase activity
GPX95_RS08585	COG0626	cystathionine gamma-synthase activity
GPX95_RS08590	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPX95_RS08595	COG0281	malic enzyme
GPX95_RS08600	COG0254	rRNA binding
GPX95_RS08605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPX95_RS08610	COG1609	Transcriptional regulator
GPX95_RS08615	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPX95_RS08620	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPX95_RS08625	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPX95_RS08630	COG1575	Belongs to the MenA family. Type 1 subfamily
GPX95_RS08635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPX95_RS08645	COG0149	triose-phosphate isomerase activity
GPX95_RS08670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPX95_RS08675	COG0459	protein refolding
GPX95_RS08685	COG1509	lysine 2,3-aminomutase activity
GPX95_RS08690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPX95_RS08695	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPX95_RS08700	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPX95_RS08705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPX95_RS08710	COG1053	succinate dehydrogenase
GPX95_RS08715	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPX95_RS08720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPX95_RS08725	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPX95_RS08730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPX95_RS08735	COG1045	serine acetyltransferase
GPX95_RS08745	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPX95_RS08750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPX95_RS08755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPX95_RS08760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPX95_RS08765	COG0137	argininosuccinate synthase activity
GPX95_RS08770	COG0165	Argininosuccinate lyase
GPX95_RS08780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPX95_RS08785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPX95_RS08785	COG0678	peroxiredoxin activity
GPX95_RS08795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPX95_RS08825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPX95_RS08830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPX95_RS08840	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPX95_RS08845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPX95_RS08850	COG0546	phosphoglycolate phosphatase activity
GPX95_RS08855	COG0180	Tryptophanyl-tRNA synthetase
GPX95_RS08870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPX95_RS08905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPX95_RS08910	COG3954	Phosphoribulokinase
GPX95_RS08920	COG0429	hydrolase of the alpha beta-hydrolase fold
GPX95_RS08930	COG0488	(ABC) transporter
GPX95_RS08935	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPX95_RS08950	COG1047	Peptidyl-prolyl cis-trans
GPX95_RS08960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPX95_RS08965	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPX95_RS08970	COG3083	sulfuric ester hydrolase activity
GPX95_RS08975	COG0557	exoribonuclease II activity
GPX95_RS08980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPX95_RS08985	COG0051	transcription antitermination factor activity, RNA binding
GPX95_RS08990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPX95_RS08995	COG0088	Forms part of the polypeptide exit tunnel
GPX95_RS09000	COG0089	rRNA binding
GPX95_RS09005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPX95_RS09010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPX95_RS09015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPX95_RS09020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPX95_RS09025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPX95_RS09030	COG0255	Belongs to the universal ribosomal protein uL29 family
GPX95_RS09040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPX95_RS09045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPX95_RS09050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPX95_RS09055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPX95_RS09060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPX95_RS09065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPX95_RS09070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPX95_RS09075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPX95_RS09080	COG1841	ribosomal large subunit assembly
GPX95_RS09085	COG0200	Binds to the 23S rRNA
GPX95_RS09090	COG0201	protein transport
GPX95_RS09100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPX95_RS09105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPX95_RS09110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPX95_RS09115	COG0202	RNA polymerase activity
GPX95_RS09120	COG0203	ribosomal protein L17
GPX95_RS09130	COG0545	Peptidyl-prolyl cis-trans isomerase
GPX95_RS09135	COG3266	domain, Protein
GPX95_RS09135	COG3061	Opacity-associated protein A
GPX95_RS09140	COG0697	spore germination
GPX95_RS09145	COG2153	protein acetylation
GPX95_RS09150	COG0513	Belongs to the DEAD box helicase family
GPX95_RS09160	COG0737	Belongs to the 5'-nucleotidase family
GPX95_RS09165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPX95_RS09165	COG1648	precorrin-2 dehydrogenase activity
GPX95_RS09170	COG0175	sulfate reduction
GPX95_RS09175	COG2895	sulfate adenylyltransferase (ATP) activity
GPX95_RS09180	COG0529	Catalyzes the synthesis of activated sulfate
GPX95_RS09200	COG1136	(ABC) transporter
GPX95_RS09200	COG0577	efflux transmembrane transporter activity
GPX95_RS09215	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPX95_RS09220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPX95_RS09225	COG0729	surface antigen
GPX95_RS09235	COG2105	PFAM AIG2 family protein
GPX95_RS09240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPX95_RS09245	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPX95_RS09250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPX95_RS09270	COG1178	ABC-type Fe3 transport system permease component
GPX95_RS09275	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPX95_RS09280	COG3028	Belongs to the UPF0307 family
GPX95_RS09285	COG0312	modulator of DNA gyrase
GPX95_RS09290	COG2239	Acts as a magnesium transporter
GPX95_RS09295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS09305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS09310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPX95_RS09320	COG1137	ATPase activity
GPX95_RS09325	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPX95_RS09340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPX95_RS09340	COG0517	IMP dehydrogenase activity
GPX95_RS09350	COG1127	ABC transporter
GPX95_RS09355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPX95_RS09360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPX95_RS09365	COG2854	intermembrane phospholipid transfer
GPX95_RS09375	COG5007	Belongs to the BolA IbaG family
GPX95_RS09380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPX95_RS09385	COG0204	Acyl-transferase
GPX95_RS09390	COG0251	oxidation-reduction process
GPX95_RS09395	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPX95_RS09400	COG0540	Belongs to the ATCase OTCase family
GPX95_RS09405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPX95_RS09410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPX95_RS09420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPX95_RS09425	COG0564	pseudouridine synthase activity
GPX95_RS09430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPX95_RS09435	COG4269	membrane
GPX95_RS09445	COG0525	valine-tRNA ligase activity
GPX95_RS09450	COG2927	DNA polymerase III (CHI subunit)
GPX95_RS09455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPX95_RS09460	COG0795	lipopolysaccharide-transporting ATPase activity
GPX95_RS09465	COG0795	lipopolysaccharide-transporting ATPase activity
GPX95_RS09485	COG0840	transmembrane signaling receptor activity
GPX95_RS09530	COG0066	3-isopropylmalate dehydratase activity
GPX95_RS09535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPX95_RS09540	COG0473	3-isopropylmalate dehydrogenase activity
GPX95_RS09545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPX95_RS09565	COG0583	DNA-binding transcription factor activity
GPX95_RS09570	COG1022	Amp-dependent synthetase and ligase
GPX95_RS09575	COG0028	Belongs to the TPP enzyme family
GPX95_RS09585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPX95_RS09590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPX95_RS09595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPX95_RS09605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPX95_RS09610	COG3079	Belongs to the UPF0149 family
GPX95_RS09615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPX95_RS09620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPX95_RS09630	COG0354	folic acid binding
GPX95_RS09635	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPX95_RS09645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPX95_RS09650	COG1595	DNA-templated transcription, initiation
GPX95_RS09665	COG3086	response to oxidative stress
GPX95_RS09670	COG0481	GTPase activity
GPX95_RS09675	COG0681	Belongs to the peptidase S26 family
GPX95_RS09680	COG0571	ribonuclease III activity
GPX95_RS09685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPX95_RS09690	COG1381	Involved in DNA repair and RecF pathway recombination
GPX95_RS09695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPX95_RS09700	COG0736	holo-[acyl-carrier-protein] synthase activity
GPX95_RS09715	COG5001	Diguanylate cyclase
GPX95_RS09720	COG2205	protein histidine kinase activity
GPX95_RS09720	COG4999	Histidine kinase
GPX95_RS09720	COG3437	response regulator, receiver
GPX95_RS09720	COG3850	Histidine kinase
GPX95_RS09725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPX95_RS09730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPX95_RS09735	COG3956	TIGRFAM MazG family protein
GPX95_RS09740	COG0504	CTP synthase activity
GPX95_RS09745	COG0148	phosphopyruvate hydratase activity
GPX95_RS09750	COG0617	tRNA 3'-terminal CCA addition
GPX95_RS09755	COG3409	Peptidoglycan-binding domain 1 protein
GPX95_RS09755	COG3267	Type II secretory pathway component ExeA
GPX95_RS09765	COG4991	sh3 domain protein
GPX95_RS09770	COG0306	phosphate transporter
GPX95_RS09775	COG1392	Phosphate transport regulator
GPX95_RS09780	COG3025	triphosphatase activity
GPX95_RS09790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPX95_RS09800	COG1538	Outer membrane efflux protein
GPX95_RS09805	COG0494	nUDIX hydrolase
GPX95_RS09810	COG3151	Protein conserved in bacteria
GPX95_RS09820	COG3150	esterase
GPX95_RS09825	COG0187	DNA topoisomerase II activity
GPX95_RS09830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPX95_RS09835	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPX95_RS09840	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPX95_RS09845	COG0237	dephospho-CoA kinase activity
GPX95_RS09855	COG1459	type II secretion system
GPX95_RS09890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPX95_RS09900	COG0737	Belongs to the 5'-nucleotidase family
GPX95_RS09905	COG2186	Transcriptional regulator
GPX95_RS09910	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPX95_RS09915	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPX95_RS09920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPX95_RS09930	COG0275	rRNA processing
GPX95_RS09935	COG3116	cell division
GPX95_RS09940	COG0768	penicillin binding
GPX95_RS09945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPX95_RS09950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPX95_RS09955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPX95_RS09960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPX95_RS09965	COG0772	Belongs to the SEDS family
GPX95_RS09975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPX95_RS09980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPX95_RS09985	COG0849	cell division
GPX95_RS09990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPX95_RS09995	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPX95_RS10005	COG0653	protein targeting
GPX95_RS10010	COG0494	nUDIX hydrolase
GPX95_RS10015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPX95_RS10020	COG0505	Belongs to the CarA family
GPX95_RS10030	COG0730	response to heat
GPX95_RS10035	COG0583	DNA-binding transcription factor activity
GPX95_RS10040	COG2860	membrane
GPX95_RS10045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPX95_RS10055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPX95_RS10065	COG0493	'glutamate synthase
GPX95_RS10070	COG0069	glutamate synthase activity
GPX95_RS10070	COG0067	glutamate synthase
GPX95_RS10070	COG0070	glutamate synthase
GPX95_RS10080	COG0067	glutamate synthase
GPX95_RS10080	COG0070	glutamate synthase
GPX95_RS10080	COG0069	glutamate synthase activity
GPX95_RS10085	COG1242	4 iron, 4 sulfur cluster binding
GPX95_RS10090	COG2203	Gaf domain
GPX95_RS10090	COG5001	Diguanylate cyclase
GPX95_RS10090	COG3706	GGDEF domain
GPX95_RS10090	COG4251	negative regulation of phosphorylation
GPX95_RS10095	COG0784	Response regulator, receiver
GPX95_RS10095	COG2198	Histidine kinase
GPX95_RS10095	COG5002	protein histidine kinase activity
GPX95_RS10100	COG0745	RESPONSE REGULATOR receiver
GPX95_RS10130	COG0083	homoserine kinase activity
GPX95_RS10140	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPX95_RS10145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPX95_RS10150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPX95_RS10165	COG1115	amino acid carrier protein
GPX95_RS10180	COG0084	hydrolase, TatD family'
GPX95_RS10185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPX95_RS10195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPX95_RS10200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPX95_RS10205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPX95_RS10210	COG0813	purine-nucleoside phosphorylase activity
GPX95_RS10220	COG0560	Phosphoserine phosphatase
GPX95_RS10230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPX95_RS10235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPX95_RS10240	COG1022	Amp-dependent synthetase and ligase
GPX95_RS10250	COG2059	Chromate
GPX95_RS10255	COG3250	beta-galactosidase activity
GPX95_RS10260	COG1609	Transcriptional regulator
GPX95_RS10265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPX95_RS10285	COG0456	acetyltransferase
GPX95_RS10295	COG2171	N-acyltransferase activity
GPX95_RS10300	COG3141	response to X-ray
GPX95_RS10315	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPX95_RS10320	COG1074	ATP-dependent DNA helicase activity
GPX95_RS10325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPX95_RS10350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPX95_RS10355	COG2166	iron-sulfur cluster assembly
GPX95_RS10360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPX95_RS10365	COG0693	protein deglycase activity
GPX95_RS10370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPX95_RS10375	COG3248	Nucleoside-binding outer membrane protein
GPX95_RS10385	COG1595	DNA-templated transcription, initiation
GPX95_RS10395	COG2211	Major facilitator Superfamily
GPX95_RS10400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPX95_RS10410	COG2813	Specifically methylates the guanine in position
GPX95_RS10415	COG0271	Belongs to the BolA IbaG family
GPX95_RS10420	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPX95_RS10425	COG1805	sodium ion transport
GPX95_RS10430	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPX95_RS10435	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPX95_RS10440	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPX95_RS10445	COG2871	sodium ion transport
GPX95_RS10450	COG1477	protein flavinylation
GPX95_RS10460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPX95_RS10470	COG4251	negative regulation of phosphorylation
GPX95_RS10470	COG2203	Gaf domain
GPX95_RS10470	COG3706	GGDEF domain
GPX95_RS10470	COG5001	Diguanylate cyclase
GPX95_RS10475	COG0733	neurotransmitter:sodium symporter activity
GPX95_RS10490	COG0189	ligase activity
GPX95_RS10490	COG4067	protein conserved in archaea
GPX95_RS10495	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPX95_RS10505	COG2252	PERMEase
GPX95_RS10510	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPX95_RS10525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPX95_RS10530	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPX95_RS10535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPX95_RS10540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPX95_RS10540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPX95_RS10555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPX95_RS10560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPX95_RS10565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPX95_RS10570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPX95_RS10580	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPX95_RS10585	COG0024	Methionine aminopeptidase
GPX95_RS10590	COG0052	Belongs to the universal ribosomal protein uS2 family
GPX95_RS10595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPX95_RS10600	COG0528	UMP kinase activity
GPX95_RS10605	COG0233	cytoplasmic translational termination
GPX95_RS10610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPX95_RS10615	COG0575	Belongs to the CDS family
GPX95_RS10625	COG0750	zinc metalloprotease
GPX95_RS10635	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPX95_RS10640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX95_RS10645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPX95_RS10650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX95_RS10655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX95_RS10660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPX95_RS10665	COG0587	DNA-directed DNA polymerase activity
GPX95_RS10670	COG0825	malonyl-CoA metabolic process
GPX95_RS10675	COG0037	tRNA processing
GPX95_RS10685	COG0347	Belongs to the P(II) protein family
GPX95_RS10695	COG0741	lytic transglycosylase activity
GPX95_RS10695	COG1388	LysM domain
GPX95_RS10700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPX95_RS10705	COG2226	methyltransferase
GPX95_RS10710	COG0328	RNA-DNA hybrid ribonuclease activity
GPX95_RS10715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPX95_RS10730	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPX95_RS10740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPX95_RS10745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPX95_RS10750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPX95_RS10755	COG3706	GGDEF domain
GPX95_RS10760	COG1187	pseudouridine synthase activity
GPX95_RS10765	COG2840	Smr protein MutS2
GPX95_RS10795	COG2608	mercury ion transmembrane transporter activity
GPX95_RS10795	COG2217	Heavy metal translocating P-type atpase
GPX95_RS10800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPX95_RS10840	COG2747	anti-sigma28 factor FlgM
GPX95_RS10850	COG0784	Response regulator, receiver
GPX95_RS10850	COG0835	chemotaxis
GPX95_RS10855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPX95_RS10860	COG1815	bacterial-type flagellum-dependent cell motility
GPX95_RS10865	COG1558	bacterial-type flagellum-dependent cell motility
GPX95_RS10870	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPX95_RS10875	COG1749	Flagellar hook protein flgE
GPX95_RS10880	COG4787	bacterial-type flagellum-dependent cell motility
GPX95_RS10885	COG4786	Flagellar basal body rod
GPX95_RS10890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPX95_RS10895	COG1706	bacterial-type flagellum-dependent cell motility
GPX95_RS10900	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPX95_RS10900	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPX95_RS10915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX95_RS10920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX95_RS11005	COG0012	GTP binding
GPX95_RS11010	COG0193	aminoacyl-tRNA hydrolase activity
GPX95_RS11015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPX95_RS11020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPX95_RS11025	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPX95_RS11030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPX95_RS11035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPX95_RS11040	COG2890	protein-(glutamine-N5) methyltransferase activity
GPX95_RS11045	COG3094	Invasion gene expression up-regulator, SirB
GPX95_RS11050	COG2912	Transglutaminase-like superfamily
GPX95_RS11055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPX95_RS11060	COG0737	Belongs to the 5'-nucleotidase family
GPX95_RS11070	COG2233	PERMEase
GPX95_RS11090	COG1393	Belongs to the ArsC family
GPX95_RS11095	COG4783	chaperone-mediated protein folding
GPX95_RS11115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPX95_RS11125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPX95_RS11130	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPX95_RS11140	COG1876	peptidase activity
GPX95_RS11145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPX95_RS11150	COG1393	Belongs to the ArsC family
GPX95_RS11170	COG2837	iron assimilation
GPX95_RS11175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX95_RS11180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX95_RS11185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX95_RS11205	COG1516	flagellar protein fliS
GPX95_RS11210	COG2204	response regulator
GPX95_RS11215	COG4191	Histidine kinase
GPX95_RS11220	COG2204	response regulator
GPX95_RS11235	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPX95_RS11285	COG1987	bacterial-type flagellum assembly
GPX95_RS11305	COG2890	protein-(glutamine-N5) methyltransferase activity
GPX95_RS11310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPX95_RS11315	COG2860	membrane
GPX95_RS11320	COG3101	peptidyl-lysine hydroxylation
GPX95_RS11330	COG0431	NADPH-dependent FMN reductase
GPX95_RS11335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPX95_RS11335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPX95_RS11340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPX95_RS11345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPX95_RS11350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPX95_RS11355	COG0735	belongs to the Fur family
GPX95_RS11365	COG0583	DNA-binding transcription factor activity
GPX95_RS11375	COG1346	cytolysis
GPX95_RS11390	COG0596	Alpha beta hydrolase
GPX95_RS11395	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPX95_RS11400	COG0033	Phosphoglucomutase
GPX95_RS11410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPX95_RS11415	COG0372	Belongs to the citrate synthase family
GPX95_RS11420	COG2009	succinate dehydrogenase
GPX95_RS11425	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPX95_RS11430	COG1053	succinate dehydrogenase
GPX95_RS11440	COG0567	Dehydrogenase, E1 component
GPX95_RS11445	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPX95_RS11450	COG0045	succinate-CoA ligase (ADP-forming) activity
GPX95_RS11460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPX95_RS11465	COG1121	(ABC) transporter
GPX95_RS11470	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPX95_RS11480	COG1918	ferrous iron import across plasma membrane
GPX95_RS11500	COG0018	arginyl-trna synthetase
GPX95_RS11515	COG2062	phosphohistidine phosphatase, SixA
GPX95_RS11530	COG0455	bacterial-type flagellum organization
GPX95_RS11545	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPX95_RS11550	COG0643	Histidine kinase
GPX95_RS11550	COG2198	Histidine kinase
GPX95_RS11555	COG2201	protein-glutamate methylesterase activity
GPX95_RS11560	COG1192	Involved in chromosome partitioning
GPX95_RS11570	COG0835	chemotaxis
GPX95_RS11580	COG4133	protoheme IX ABC transporter activity
GPX95_RS11585	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPX95_RS11600	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPX95_RS11610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPX95_RS11615	COG3088	subunit of a heme lyase
GPX95_RS11615	COG4235	cytochrome complex assembly
GPX95_RS11625	COG2853	Lipoprotein
GPX95_RS11645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPX95_RS11650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPX95_RS11655	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPX95_RS11670	COG3083	sulfuric ester hydrolase activity
GPX95_RS11680	COG3081	Nucleoid-associated protein
GPX95_RS11690	COG1757	Na H antiporter
GPX95_RS11700	COG2095	MarC family integral membrane protein
GPX95_RS11715	COG0659	secondary active sulfate transmembrane transporter activity
GPX95_RS11720	COG1530	ribonuclease E activity
GPX95_RS11730	COG0424	maF-like protein
GPX95_RS11735	COG1399	metal-binding, possibly nucleic acid-binding protein
GPX95_RS11740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPX95_RS11745	COG0416	fatty acid biosynthetic process
GPX95_RS11750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPX95_RS11765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPX95_RS11770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPX95_RS11775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPX95_RS11780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPX95_RS11785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPX95_RS11790	COG0470	DNA polymerase III
GPX95_RS11795	COG0084	hydrolase, TatD family'
GPX95_RS11800	COG1263	PTS System
GPX95_RS11800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX95_RS11815	COG0733	neurotransmitter:sodium symporter activity
GPX95_RS11830	COG4667	esterase of the alpha-beta hydrolase superfamily
GPX95_RS11840	COG1940	carbohydrate kinase activity
GPX95_RS11875	COG2226	methyltransferase
GPX95_RS11885	COG0676	glucose-6-phosphate 1-epimerase activity
GPX95_RS11890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPX95_RS11895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPX95_RS11905	COG3139	Protein of unknown function (DUF1315)
GPX95_RS11910	COG0252	asparaginase activity
GPX95_RS11915	COG0616	signal peptide processing
GPX95_RS11920	COG1902	pentaerythritol trinitrate reductase activity
GPX95_RS11920	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPX95_RS11925	COG0788	formyltetrahydrofolate deformylase activity
GPX95_RS11935	COG1199	ATP-dependent helicase activity
GPX95_RS11940	COG1214	PFAM Peptidase M22, glycoprotease
GPX95_RS11955	COG0596	Alpha beta hydrolase
GPX95_RS11960	COG0318	PFAM AMP-dependent synthetase and ligase
GPX95_RS11965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPX95_RS11980	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPX95_RS11985	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPX95_RS11990	COG0436	Aminotransferase
GPX95_RS11995	COG1169	isochorismate synthase
GPX95_RS12005	COG0596	Alpha beta hydrolase
GPX95_RS12015	COG1441	menaquinone biosynthetic process
GPX95_RS12025	COG3135	benzoate transporter
GPX95_RS12030	COG1396	sequence-specific DNA binding
GPX95_RS12040	COG0477	Major facilitator Superfamily
GPX95_RS12060	COG3015	lipoprotein NlpE involved in copper resistance
GPX95_RS12065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPX95_RS12070	COG2894	cell division
GPX95_RS12075	COG0850	regulation of cytokinetic process
GPX95_RS12085	COG3100	YcgL domain-containing protein
GPX95_RS12100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPX95_RS12105	COG3469	chitinase activity
GPX95_RS12105	COG3325	Belongs to the glycosyl hydrolase 18 family
GPX95_RS12115	COG0243	molybdopterin cofactor binding
GPX95_RS12120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPX95_RS12160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPX95_RS12165	COG1120	ATPase activity
GPX95_RS12210	COG3842	ATPase activity
GPX95_RS12225	COG0671	phosphoesterase, PA-phosphatase related
GPX95_RS12240	COG4589	Belongs to the CDS family
GPX95_RS12250	COG5001	Diguanylate cyclase
GPX95_RS12250	COG3300	MHYT domain
GPX95_RS12265	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPX95_RS12270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPX95_RS12275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPX95_RS12280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPX95_RS12290	COG4191	Histidine kinase
GPX95_RS12300	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPX95_RS12310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPX95_RS12315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPX95_RS12320	COG0776	regulation of translation
GPX95_RS12325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPX95_RS12330	COG1555	photosystem II stabilization
GPX95_RS12335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPX95_RS12340	COG0539	negative regulation of cytoplasmic translation
GPX95_RS12345	COG0776	regulation of translation
GPX95_RS12350	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPX95_RS12355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPX95_RS12360	COG0284	orotidine-5'-phosphate decarboxylase activity
GPX95_RS12375	COG0583	DNA-binding transcription factor activity
GPX95_RS12385	COG0686	Belongs to the AlaDH PNT family
GPX95_RS12390	COG1522	sequence-specific DNA binding
GPX95_RS12395	COG1674	ftsk spoiiie
GPX95_RS12400	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPX95_RS12410	COG2186	Transcriptional regulator
GPX95_RS12425	COG0537	adenosine 5'-monophosphoramidase activity
GPX95_RS12455	COG1252	NADH dehydrogenase
GPX95_RS12485	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPX95_RS12490	COG1136	(ABC) transporter
GPX95_RS12495	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPX95_RS12505	COG2333	competence protein COMEC
GPX95_RS12505	COG0658	competence protein
GPX95_RS12510	COG1132	(ABC) transporter
GPX95_RS12515	COG1663	tetraacyldisaccharide 4'-kinase activity
GPX95_RS12525	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPX95_RS12530	COG2719	SpoVR family
GPX95_RS12535	COG2718	Belongs to the UPF0229 family
GPX95_RS12540	COG2766	serine protein kinase
GPX95_RS12545	COG3013	Belongs to the UPF0304 family
GPX95_RS12555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPX95_RS12560	COG0840	transmembrane signaling receptor activity
GPX95_RS12570	COG1882	Formate acetyltransferase
GPX95_RS12590	COG4215	(ABC) transporter
GPX95_RS12595	COG4160	amino acid transport
GPX95_RS12600	COG0708	Exodeoxyribonuclease III
GPX95_RS12605	COG0840	transmembrane signaling receptor activity
GPX95_RS12615	COG3923	Primosomal replication protein n
GPX95_RS12620	COG0730	response to heat
GPX95_RS12625	COG1199	ATP-dependent helicase activity
GPX95_RS12645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPX95_RS12650	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX95_RS12655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPX95_RS12660	COG0215	cysteine-tRNA ligase activity
GPX95_RS12665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPX95_RS12670	COG0632	four-way junction helicase activity
GPX95_RS12675	COG2255	four-way junction helicase activity
GPX95_RS12680	COG1271	oxidase subunit
GPX95_RS12685	COG1294	oxidase, subunit
GPX95_RS12690	COG4890	Cyd operon protein YbgT
GPX95_RS12695	COG3790	cyd operon protein YbgE
GPX95_RS12700	COG0824	Thioesterase
GPX95_RS12705	COG0811	peptide transport
GPX95_RS12720	COG0823	Involved in the tonB-independent uptake of proteins
GPX95_RS12725	COG2885	chlorophyll binding
GPX95_RS12745	COG5002	protein histidine kinase activity
GPX95_RS12745	COG0784	Response regulator, receiver
GPX95_RS12760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS12760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS12760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS12765	COG2207	Transcriptional regulator
GPX95_RS12775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS12780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS12785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS12790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS12790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS12790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS12795	COG4628	conserved protein (DUF2132)
GPX95_RS12805	COG0415	Belongs to the DNA photolyase family
GPX95_RS12815	COG5001	Diguanylate cyclase
GPX95_RS12830	COG4409	exo-alpha-(2->6)-sialidase activity
GPX95_RS12835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPX95_RS12840	COG1940	carbohydrate kinase activity
GPX95_RS12845	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPX95_RS12855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPX95_RS12860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPX95_RS12870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPX95_RS12880	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPX95_RS12885	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPX95_RS12920	COG2003	Belongs to the UPF0758 family
GPX95_RS12975	COG3501	Rhs element vgr protein
GPX95_RS13020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPX95_RS13030	COG0582	viral genome integration into host DNA
GPX95_RS13055	COG3069	C4-dicarboxylate transmembrane transporter activity
GPX95_RS13060	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPX95_RS13070	COG3385	transposase activity
GPX95_RS13075	COG2200	EAL domain
GPX95_RS13095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPX95_RS13095	COG3008	intermembrane lipid transfer
GPX95_RS13100	COG2995	paraquat-inducible protein a
GPX95_RS13120	COG1012	belongs to the aldehyde dehydrogenase family
GPX95_RS13145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPX95_RS13150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPX95_RS13155	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPX95_RS13165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPX95_RS13175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPX95_RS13180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPX95_RS13185	COG0297	glycogen (starch) synthase activity
GPX95_RS13205	COG3070	regulator of competence-specific genes
GPX95_RS13210	COG1609	Transcriptional regulator
GPX95_RS13215	COG3381	protein complex oligomerization
GPX95_RS13220	COG0745	RESPONSE REGULATOR receiver
GPX95_RS13235	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPX95_RS13240	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPX95_RS13245	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPX95_RS13250	COG1979	alcohol dehydrogenase
GPX95_RS13255	COG2207	Transcriptional regulator
GPX95_RS13275	COG1032	radical SAM domain protein
GPX95_RS13280	COG2199	diguanylate cyclase activity
GPX95_RS13280	COG2200	EAL domain
GPX95_RS13280	COG2203	Gaf domain
GPX95_RS13285	COG0612	Peptidase, M16
GPX95_RS13300	COG0583	DNA-binding transcription factor activity
GPX95_RS13315	COG0038	chloride channel
GPX95_RS13320	COG0523	cobalamin synthesis protein
GPX95_RS13335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPX95_RS13335	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPX95_RS13335	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPX95_RS13335	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPX95_RS13340	COG2205	protein histidine kinase activity
GPX95_RS13345	COG0745	RESPONSE REGULATOR receiver
GPX95_RS13350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPX95_RS13365	COG2200	EAL domain
GPX95_RS13375	COG3038	cytochrome b561
GPX95_RS13385	COG2116	formate transmembrane transporter activity
GPX95_RS13390	COG0583	DNA-binding transcription factor activity
GPX95_RS13400	COG3593	DNA synthesis involved in DNA repair
GPX95_RS13405	COG0737	Belongs to the 5'-nucleotidase family
GPX95_RS13410	COG0861	Integral membrane protein TerC family
GPX95_RS13420	COG2824	Alkylphosphonate utilization operon protein PhnA
GPX95_RS13475	COG3706	GGDEF domain
GPX95_RS13495	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPX95_RS13525	COG0023	Translation Initiation Factor
GPX95_RS13535	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPX95_RS13545	COG0045	succinate-CoA ligase (ADP-forming) activity
GPX95_RS13545	COG1042	CoA-binding domain protein
GPX95_RS13545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX95_RS13550	COG0583	DNA-binding transcription factor activity
GPX95_RS13555	COG4771	TonB-dependent receptor
GPX95_RS13555	COG1629	transport
GPX95_RS13570	COG2050	protein possibly involved in aromatic compounds catabolism
GPX95_RS13575	COG0501	Belongs to the peptidase M48B family
GPX95_RS13590	COG0625	glutathione transferase activity
GPX95_RS13605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPX95_RS13610	COG4172	Belongs to the ABC transporter superfamily
GPX95_RS13620	COG4174	ABC transporter (Permease)
GPX95_RS13625	COG4166	transmembrane transport
GPX95_RS13670	COG3842	ATPase activity
GPX95_RS13680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPX95_RS13690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPX95_RS13695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPX95_RS13705	COG3842	ATPase activity
GPX95_RS13715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX95_RS13730	COG1175	transmembrane transport
GPX95_RS13735	COG3833	ABC-type maltose transport systems, permease component
GPX95_RS13755	COG1011	Hydrolase
GPX95_RS13765	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPX95_RS13770	COG1970	mechanosensitive ion channel activity
GPX95_RS13775	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPX95_RS13780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPX95_RS13780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPX95_RS13785	COG0302	gtp cyclohydrolase
GPX95_RS13795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPX95_RS13805	COG2897	thiosulfate sulfurtransferase activity
GPX95_RS13815	COG2390	Transcriptional regulator
GPX95_RS13820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPX95_RS13825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPX95_RS13860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPX95_RS13885	COG0583	DNA-binding transcription factor activity
GPX95_RS13890	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPX95_RS13910	COG2391	methyltransferase activity
GPX95_RS13920	COG0640	Transcriptional regulator
GPX95_RS13975	COG1263	PTS System
GPX95_RS13975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX95_RS13985	COG1621	beta-fructofuranosidase activity
GPX95_RS13995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPX95_RS14000	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GPX95_RS14000	COG2885	chlorophyll binding
GPX95_RS14005	COG0545	Peptidyl-prolyl cis-trans isomerase
GPX95_RS14010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPX95_RS14015	COG0840	transmembrane signaling receptor activity
GPX95_RS14020	COG3069	C4-dicarboxylate transmembrane transporter activity
GPX95_RS14025	COG1760	l-serine dehydratase
GPX95_RS14030	COG2197	response regulator
GPX95_RS14035	COG3850	Histidine kinase
GPX95_RS14040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPX95_RS14050	COG0243	molybdopterin cofactor binding
GPX95_RS14060	COG3005	denitrification pathway
GPX95_RS14070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPX95_RS14075	COG2197	response regulator
GPX95_RS14080	COG3851	Histidine kinase
GPX95_RS14085	COG2271	Major facilitator Superfamily
GPX95_RS14090	COG1840	ABC-type Fe3 transport system, periplasmic component
GPX95_RS14100	COG3842	ATPase activity
GPX95_RS14105	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPX95_RS14115	COG0183	Belongs to the thiolase family
GPX95_RS14125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPX95_RS14130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPX95_RS14150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPX95_RS14160	COG1979	alcohol dehydrogenase
GPX95_RS14175	COG4191	Histidine kinase
GPX95_RS14180	COG1840	ABC-type Fe3 transport system, periplasmic component
GPX95_RS14185	COG2271	Major facilitator Superfamily
GPX95_RS14190	COG0469	pyruvate kinase activity
GPX95_RS14200	COG1879	ABC-type sugar transport system periplasmic component
GPX95_RS14205	COG1803	Methylglyoxal synthase
GPX95_RS14210	COG1335	isochorismatase
GPX95_RS14220	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPX95_RS14235	COG0210	DNA helicase
GPX95_RS14240	COG1289	transmembrane transporter activity
GPX95_RS14270	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPX95_RS14275	COG4149	molybdate abc transporter
GPX95_RS14280	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPX95_RS14285	COG1492	cobalamin metabolic process
GPX95_RS14305	COG0784	Response regulator, receiver
GPX95_RS14305	COG5002	protein histidine kinase activity
GPX95_RS14310	COG1879	ABC-type sugar transport system periplasmic component
GPX95_RS14320	COG2827	Endonuclease containing a URI domain
GPX95_RS14345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPX95_RS14350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPX95_RS14355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPX95_RS14365	COG0247	lactate metabolic process
GPX95_RS14370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPX95_RS14375	COG3118	belongs to the thioredoxin family
GPX95_RS14390	COG0840	transmembrane signaling receptor activity
GPX95_RS14410	COG4160	amino acid transport
GPX95_RS14415	COG4215	(ABC) transporter
GPX95_RS14420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX95_RS14425	COG1126	abc transporter atp-binding protein
GPX95_RS14435	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPX95_RS14445	COG0494	nUDIX hydrolase
GPX95_RS14450	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPX95_RS14460	COG1309	transcriptional regulator
GPX95_RS14465	COG0513	Belongs to the DEAD box helicase family
GPX95_RS14480	COG0840	transmembrane signaling receptor activity
GPX95_RS14485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPX95_RS14490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPX95_RS14495	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPX95_RS14500	COG1984	allophanate hydrolase subunit 2
GPX95_RS14515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPX95_RS14520	COG4181	ATPase activity
GPX95_RS14530	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPX95_RS14535	COG1716	ATPase activity
GPX95_RS14535	COG5001	Diguanylate cyclase
GPX95_RS14545	COG0484	heat shock protein binding
GPX95_RS14575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX95_RS14580	COG1368	sulfuric ester hydrolase activity
GPX95_RS14590	COG0513	Belongs to the DEAD box helicase family
GPX95_RS14595	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPX95_RS14605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPX95_RS14615	COG3046	protein related to deoxyribodipyrimidine photolyase
GPX95_RS14620	COG3397	chitin binding
GPX95_RS14625	COG2814	Major facilitator Superfamily
GPX95_RS14630	COG2207	Transcriptional regulator
GPX95_RS14630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPX95_RS14640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPX95_RS14660	COG0745	RESPONSE REGULATOR receiver
GPX95_RS14710	COG0561	phosphatase activity
GPX95_RS14715	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPX95_RS14720	COG3623	hexulose-6-phosphate isomerase
GPX95_RS14735	COG2149	membrane
GPX95_RS14745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX95_RS14745	COG1263	PTS System
GPX95_RS14750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPX95_RS14770	COG0604	alcohol dehydrogenase
GPX95_RS14775	COG1902	pentaerythritol trinitrate reductase activity
GPX95_RS14780	COG1902	pentaerythritol trinitrate reductase activity
GPX95_RS14800	COG0583	DNA-binding transcription factor activity
GPX95_RS14805	COG2814	Major facilitator Superfamily
GPX95_RS14815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPX95_RS14835	COG4604	ABC transporter, ATP-binding protein
GPX95_RS14840	COG4605	iron ion homeostasis
GPX95_RS14845	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPX95_RS14865	COG4412	M6 family metalloprotease domain protein
GPX95_RS14865	COG3291	Pkd domain containing protein
GPX95_RS14870	COG5380	lipid catabolic process
GPX95_RS14875	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPX95_RS14880	COG0840	transmembrane signaling receptor activity
GPX95_RS14890	COG3240	lipase activity
GPX95_RS14895	COG3706	GGDEF domain
GPX95_RS14905	COG2814	Major facilitator Superfamily
GPX95_RS14910	COG1757	Na H antiporter
GPX95_RS14925	COG0784	Response regulator, receiver
GPX95_RS14925	COG3437	response regulator, receiver
GPX95_RS14930	COG0840	transmembrane signaling receptor activity
GPX95_RS14935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPX95_RS14940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPX95_RS14945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPX95_RS14950	COG0513	Belongs to the DEAD box helicase family
GPX95_RS14955	COG0516	GMP reductase activity
GPX95_RS14965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPX95_RS14975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPX95_RS14980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPX95_RS14980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPX95_RS14985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPX95_RS14985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPX95_RS15015	COG1278	Cold shock
GPX95_RS15020	COG1017	nitric oxide dioxygenase activity
GPX95_RS15020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPX95_RS15025	COG3604	Transcriptional regulator
GPX95_RS15035	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPX95_RS15040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPX95_RS15055	COG0840	transmembrane signaling receptor activity
GPX95_RS15060	COG0714	Associated with various cellular activities
GPX95_RS15080	COG2304	oxidoreductase activity
GPX95_RS15095	COG1278	Cold shock
GPX95_RS15110	COG3530	Putative quorum-sensing-regulated virulence factor
GPX95_RS15120	COG3033	Beta-eliminating lyase
GPX95_RS15125	COG0814	amino acid
GPX95_RS15130	COG0488	(ABC) transporter
GPX95_RS15150	COG0579	oxidoreductase
GPX95_RS15195	COG2271	Major facilitator Superfamily
GPX95_RS15200	COG0584	glycerophosphoryl diester phosphodiesterase
GPX95_RS15210	COG3447	MASE1 domain protein
GPX95_RS15210	COG5001	Diguanylate cyclase
GPX95_RS15210	COG5002	protein histidine kinase activity
GPX95_RS15220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX95_RS15225	COG1879	ABC-type sugar transport system periplasmic component
GPX95_RS15240	COG1869	D-ribose catabolic process
GPX95_RS15260	COG3501	Rhs element vgr protein
GPX95_RS15360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPX95_RS15365	COG2771	luxR family
GPX95_RS15365	COG2200	EAL domain
GPX95_RS15375	COG0840	transmembrane signaling receptor activity
GPX95_RS15380	COG0673	inositol 2-dehydrogenase activity
GPX95_RS15385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPX95_RS15400	COG1342	Belongs to the UPF0251 family
GPX95_RS15415	COG1301	dicarboxylic acid transport
GPX95_RS15420	COG0700	Nucleoside recognition
GPX95_RS15425	COG3366	ferrous iron transmembrane transporter activity
GPX95_RS15435	COG4565	transcriptional regulatory protein
GPX95_RS15445	COG0471	metal ion transport
GPX95_RS15460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPX95_RS15465	COG2259	Doxx family
GPX95_RS15490	COG0363	glucosamine-6-phosphate deaminase activity
GPX95_RS15500	COG0583	DNA-binding transcription factor activity
GPX95_RS15505	COG0366	Alpha amylase catalytic
GPX95_RS15510	COG1523	belongs to the glycosyl hydrolase 13 family
GPX95_RS15535	COG1914	H( )-stimulated, divalent metal cation uptake system
GPX95_RS15545	COG0840	transmembrane signaling receptor activity
GPX95_RS15560	COG0840	transmembrane signaling receptor activity
GPX95_RS15575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPX95_RS15585	COG0513	Belongs to the DEAD box helicase family
GPX95_RS15595	COG2186	Transcriptional regulator
GPX95_RS15605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPX95_RS15615	COG0246	Mannitol dehydrogenase
GPX95_RS15620	COG1904	glucuronate isomerase
GPX95_RS15625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX95_RS15630	COG0800	Aldolase
GPX95_RS15640	COG0583	DNA-binding transcription factor activity
GPX95_RS15655	COG3385	transposase activity
GPX95_RS15665	COG1132	(ABC) transporter
GPX95_RS15675	COG1902	pentaerythritol trinitrate reductase activity
GPX95_RS15685	COG1280	lysine exporter protein (LysE YggA)
GPX95_RS15690	COG2207	Transcriptional regulator
GPX95_RS15710	COG1846	Transcriptional regulator
GPX95_RS15715	COG1764	response to oxidative stress
GPX95_RS15720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPX95_RS15725	COG0697	spore germination
GPX95_RS15750	COG0583	DNA-binding transcription factor activity
GPX95_RS15755	COG3300	MHYT domain
GPX95_RS15755	COG5001	Diguanylate cyclase
GPX95_RS15760	COG0739	heme binding
GPX95_RS15770	COG0659	secondary active sulfate transmembrane transporter activity
GPX95_RS15785	COG2199	diguanylate cyclase activity
GPX95_RS15790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPX95_RS15795	COG0581	inorganic phosphate transmembrane transporter activity
GPX95_RS15805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPX95_RS15830	COG4771	TonB-dependent receptor
GPX95_RS15835	COG1770	oligopeptidase
GPX95_RS15840	COG0513	Belongs to the DEAD box helicase family
GPX95_RS15850	COG1388	LysM domain
GPX95_RS15850	COG1376	ErfK ybiS ycfS ynhG family protein
GPX95_RS15855	COG0415	Belongs to the DNA photolyase family
GPX95_RS15860	COG0789	Transcriptional regulator
GPX95_RS15865	COG3272	Protein of unknown function (DUF1722)
GPX95_RS15870	COG0813	purine-nucleoside phosphorylase activity
GPX95_RS15885	COG3706	GGDEF domain
GPX95_RS15905	COG0786	glutamate:sodium symporter activity
GPX95_RS15920	COG1999	signal sequence binding
GPX95_RS15935	COG0671	phosphoesterase, PA-phosphatase related
GPX95_RS15975	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPX95_RS15980	COG0471	metal ion transport
GPX95_RS16080	COG3501	Rhs element vgr protein
GPX95_RS16090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPX95_RS16095	COG1640	4-alpha-glucanotransferase
GPX95_RS16100	COG0058	SHG alpha-glucan phosphorylase activity
GPX95_RS16105	COG2909	trisaccharide binding
GPX95_RS16120	COG2084	Dehydrogenase
GPX95_RS16125	COG0217	transcriptional regulatory protein
GPX95_RS16160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPX95_RS16165	COG1444	tRNA N-acetyltransferase activity
GPX95_RS16175	COG1022	Amp-dependent synthetase and ligase
GPX95_RS16185	COG4221	oxidoreductase activity
GPX95_RS16200	COG0642	Histidine kinase
GPX95_RS16205	COG2194	sulfuric ester hydrolase activity
GPX95_RS16215	COG0745	RESPONSE REGULATOR receiver
GPX95_RS16220	COG2198	Histidine kinase
GPX95_RS16220	COG0643	Histidine kinase
GPX95_RS16225	COG0835	chemotaxis
GPX95_RS16230	COG0835	chemotaxis
GPX95_RS16235	COG0840	transmembrane signaling receptor activity
GPX95_RS16240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPX95_RS16265	COG0745	RESPONSE REGULATOR receiver
GPX95_RS16295	COG0259	pyridoxamine-phosphate oxidase activity
GPX95_RS16305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPX95_RS16330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPX95_RS16360	COG1982	Orn Lys Arg decarboxylase major
GPX95_RS16365	COG0531	amino acid
GPX95_RS16370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPX95_RS16375	COG1901	pseudouridine methyltransferase
GPX95_RS16385	COG4221	oxidoreductase activity
GPX95_RS16400	COG2910	NAD(P)H-binding
GPX95_RS16410	COG1335	isochorismatase
GPX95_RS16425	COG0697	spore germination
GPX95_RS16445	COG0673	inositol 2-dehydrogenase activity
GPX95_RS16450	COG3722	fumarate hydratase activity
GPX95_RS16455	COG0246	Mannitol dehydrogenase
GPX95_RS16460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS16460	COG2213	PTS system mannitol-specific
GPX95_RS16465	COG0739	heme binding
GPX95_RS16475	COG3385	transposase activity
GPX95_RS16480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPX95_RS16485	COG4597	amino acid ABC transporter
GPX95_RS16490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX95_RS16500	COG1126	abc transporter atp-binding protein
GPX95_RS16505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPX95_RS16510	COG0534	Mate efflux family protein
GPX95_RS16515	COG0840	transmembrane signaling receptor activity
GPX95_RS16520	COG0840	transmembrane signaling receptor activity
GPX95_RS16530	COG1304	FMN binding
GPX95_RS16535	COG1620	l-lactate permease
GPX95_RS16540	COG0583	DNA-binding transcription factor activity
GPX95_RS16575	COG2211	Major facilitator Superfamily
GPX95_RS16585	COG3123	guanosine phosphorylase activity
GPX95_RS16590	COG1741	Belongs to the pirin family
GPX95_RS16600	COG5001	Diguanylate cyclase
GPX95_RS16605	COG0583	DNA-binding transcription factor activity
GPX95_RS16625	COG3706	GGDEF domain
GPX95_RS16645	COG1846	Transcriptional regulator
GPX95_RS16650	COG0835	chemotaxis
GPX95_RS16650	COG0784	Response regulator, receiver
GPX95_RS16655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPX95_RS16665	COG0393	Putative heavy-metal-binding
GPX95_RS16680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX95_RS16685	COG3842	ATPase activity
GPX95_RS16695	COG1175	transmembrane transport
GPX95_RS16700	COG3833	ABC-type maltose transport systems, permease component
GPX95_RS16715	COG1349	DNA-binding transcription factor activity
GPX95_RS16720	COG3706	GGDEF domain
GPX95_RS16730	COG2207	Transcriptional regulator
GPX95_RS16730	COG4753	response regulator
GPX95_RS16740	COG1278	Cold shock
GPX95_RS16745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPX95_RS16755	COG0488	(ABC) transporter
GPX95_RS16760	COG2354	Protein conserved in bacteria
GPX95_RS16765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPX95_RS16770	COG0418	dihydroorotase activity
GPX95_RS16775	COG3217	Mosc domain protein beta barrel domain protein
GPX95_RS16775	COG0633	Ferredoxin
GPX95_RS16775	COG3217	Mosc domain protein beta barrel domain protein
GPX95_RS16775	COG0633	Ferredoxin
GPX95_RS16810	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPX95_RS16815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPX95_RS16825	COG0848	biopolymer transport protein
GPX95_RS16830	COG0811	peptide transport
GPX95_RS16835	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPX95_RS16845	COG3721	Heme iron utilization protein
GPX95_RS16850	COG0748	coenzyme F420 binding
GPX95_RS16865	COG1929	Belongs to the glycerate kinase type-1 family
GPX95_RS16895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPX95_RS16900	COG0363	glucosamine-6-phosphate deaminase activity
GPX95_RS16905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPX95_RS16910	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPX95_RS16915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPX95_RS16935	COG0346	lactoylglutathione lyase activity
GPX95_RS16945	COG2873	o-acetylhomoserine
GPX95_RS16950	COG0156	8-amino-7-oxononanoate synthase activity
GPX95_RS16955	COG1063	alcohol dehydrogenase
GPX95_RS16980	COG0582	viral genome integration into host DNA
GPX95_RS17000	COG4626	Terminase
GPX95_RS17000	COG1802	Transcriptional regulator
GPX95_RS17025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPX95_RS17030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPX95_RS17145	COG2610	gluconate transmembrane transporter activity
GPX95_RS17150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPX95_RS17155	COG3622	Belongs to the hyi family
GPX95_RS17160	COG0235	Class ii aldolase
GPX95_RS17165	COG3395	kinase activity
GPX95_RS17170	COG2084	Dehydrogenase
GPX95_RS17185	COG3157	Type VI secretion system effector, Hcp
GPX95_RS17205	COG1063	alcohol dehydrogenase
GPX95_RS17240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPX95_RS17245	COG0583	DNA-binding transcription factor activity
GPX95_RS17250	COG1686	Belongs to the peptidase S11 family
GPX95_RS17260	COG3047	cAMP biosynthetic process
GPX95_RS17270	COG2267	carboxylic ester hydrolase activity
GPX95_RS17275	COG2067	long-chain fatty acid transport protein
GPX95_RS17280	COG0366	Alpha amylase catalytic
GPX95_RS17285	COG4989	oxidoreductase activity
GPX95_RS17320	COG3279	Response regulator of the LytR AlgR family
GPX95_RS17330	COG3706	GGDEF domain
GPX95_RS17360	COG1765	OsmC-like protein
GPX95_RS17365	COG1253	flavin adenine dinucleotide binding
GPX95_RS17370	COG2171	N-acyltransferase activity
GPX95_RS17385	COG0583	DNA-binding transcription factor activity
GPX95_RS17390	COG2264	protein methyltransferase activity
GPX95_RS17405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPX95_RS17410	COG3186	Phenylalanine-4-hydroxylase
GPX95_RS17415	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPX95_RS17420	COG0534	Mate efflux family protein
GPX95_RS17435	COG0456	acetyltransferase
GPX95_RS17440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPX95_RS17445	COG0662	Cupin 2, conserved barrel domain protein
GPX95_RS17455	COG2239	Acts as a magnesium transporter
GPX95_RS17480	COG1166	arginine decarboxylase activity
GPX95_RS17485	COG0010	Belongs to the arginase family
GPX95_RS17500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX95_RS17505	COG0800	Aldolase
GPX95_RS17510	COG1085	galactose-1-phosphate uridylyltransferase
GPX95_RS17515	COG1028	Short-chain dehydrogenase reductase Sdr
GPX95_RS17540	COG3119	arylsulfatase activity
GPX95_RS17545	COG3119	arylsulfatase activity
GPX95_RS17550	COG0641	radical SAM
GPX95_RS17570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPX95_RS17580	COG1414	Transcriptional regulator
GPX95_RS17595	COG1686	Belongs to the peptidase S11 family
GPX95_RS17610	COG3338	carbonate dehydratase activity
GPX95_RS17615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPX95_RS17615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPX95_RS17620	COG0509	glycine decarboxylation via glycine cleavage system
GPX95_RS17625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPX95_RS17635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPX95_RS17640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPX95_RS17650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPX95_RS17655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPX95_RS17690	COG0456	acetyltransferase
GPX95_RS17780	COG0346	lactoylglutathione lyase activity
GPX95_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
GPX95_RS17875	COG3040	lipid binding
GPX95_RS17940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX95_RS17955	COG0346	lactoylglutathione lyase activity
GPX95_RS17970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPX95_RS18070	COG0346	lactoylglutathione lyase activity
GPX95_RS18095	COG0653	protein targeting
GPX95_RS18125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPX95_RS18185	COG0346	lactoylglutathione lyase activity
GPX95_RS18340	COG3040	lipid binding
GPX95_RS18465	COG4977	sequence-specific DNA binding
GPX95_RS18570	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPX95_RS18600	COG1328	CTP reductase activity
GPX95_RS18605	COG0602	queuosine metabolic process
GPX95_RS18615	COG0189	ligase activity
GPX95_RS18615	COG4067	protein conserved in archaea
GPX95_RS18620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS18620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX95_RS18620	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPX95_RS18625	COG1105	Belongs to the carbohydrate kinase PfkB family
GPX95_RS18630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS18630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX95_RS18635	COG1609	Transcriptional regulator
GPX95_RS18645	COG0419	ATPase involved in DNA repair
GPX95_RS18650	COG2205	protein histidine kinase activity
GPX95_RS18650	COG0784	Response regulator, receiver