locus-tag	class	description
EWA65_RS00010	COG0049	tRNA binding
EWA65_RS00015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EWA65_RS00020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EWA65_RS00025	COG2906	2 iron, 2 sulfur cluster binding
EWA65_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
EWA65_RS00040	COG2965	DNA replication, synthesis of RNA primer
EWA65_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EWA65_RS00050	COG0359	binds to the 23S rRNA
EWA65_RS00065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EWA65_RS00075	COG0166	Belongs to the GPI family
EWA65_RS00090	COG0735	belongs to the Fur family
EWA65_RS00095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EWA65_RS00115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EWA65_RS00120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EWA65_RS00125	COG0175	sulfate reduction
EWA65_RS00195	COG0646	methionine synthase
EWA65_RS00195	COG1410	methionine synthase
EWA65_RS00205	COG0527	aspartate kinase activity
EWA65_RS00210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EWA65_RS00220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EWA65_RS00240	COG2200	EAL domain
EWA65_RS00240	COG2199	diguanylate cyclase activity
EWA65_RS00265	COG3409	Peptidoglycan-binding domain 1 protein
EWA65_RS00265	COG3267	Type II secretory pathway component ExeA
EWA65_RS00275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EWA65_RS00280	COG1459	type II secretion system
EWA65_RS00290	COG2165	general secretion pathway protein
EWA65_RS00295	COG2165	general secretion pathway protein
EWA65_RS00325	COG1077	Cell shape determining protein MreB Mrl
EWA65_RS00330	COG1792	Involved in formation and maintenance of cell shape
EWA65_RS00335	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EWA65_RS00340	COG0424	maF-like protein
EWA65_RS00350	COG3164	Protein of unknown function
EWA65_RS00355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EWA65_RS00360	COG0312	modulator of DNA gyrase
EWA65_RS00365	COG1151	hydroxylamine reductase activity
EWA65_RS00370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EWA65_RS00375	COG2235	arginine
EWA65_RS00395	COG0589	response to stress
EWA65_RS00410	COG1438	arginine binding
EWA65_RS00415	COG0039	L-malate dehydrogenase activity
EWA65_RS00420	COG0531	amino acid
EWA65_RS00425	COG0142	geranyltranstransferase activity
EWA65_RS00430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EWA65_RS00435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EWA65_RS00440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EWA65_RS00445	COG3610	response to peptide
EWA65_RS00450	COG3610	response to peptide
EWA65_RS00460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EWA65_RS00465	COG2967	ApaG domain
EWA65_RS00470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EWA65_RS00475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EWA65_RS00480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EWA65_RS00485	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EWA65_RS00490	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EWA65_RS00520	COG0840	transmembrane signaling receptor activity
EWA65_RS00545	COG0741	lytic transglycosylase activity
EWA65_RS00550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EWA65_RS00555	COG1194	a g-specific adenine glycosylase
EWA65_RS00560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EWA65_RS00565	COG2066	Belongs to the glutaminase family
EWA65_RS00570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EWA65_RS00575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EWA65_RS00590	COG0762	integral membrane protein
EWA65_RS00595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EWA65_RS00600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EWA65_RS00620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EWA65_RS00625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EWA65_RS00630	COG1678	Uncharacterized ACR, COG1678
EWA65_RS00635	COG0189	ligase activity
EWA65_RS00640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EWA65_RS00645	COG2356	endonuclease I
EWA65_RS00655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EWA65_RS00660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EWA65_RS00665	COG0583	DNA-binding transcription factor activity
EWA65_RS00670	COG4771	TonB-dependent receptor
EWA65_RS00675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EWA65_RS00680	COG0126	phosphoglycerate kinase activity
EWA65_RS00685	COG0191	fructose-bisphosphate aldolase activity
EWA65_RS00690	COG0668	transmembrane transport
EWA65_RS00700	COG1279	arginine transmembrane transporter activity
EWA65_RS00715	COG3385	transposase activity
EWA65_RS00725	COG1349	DNA-binding transcription factor activity
EWA65_RS00730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EWA65_RS00735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EWA65_RS00755	COG0358	DNA primase activity
EWA65_RS00760	COG1610	YqeY-like protein
EWA65_RS00765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EWA65_RS00770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EWA65_RS00775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EWA65_RS00780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EWA65_RS00785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EWA65_RS00790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EWA65_RS00795	COG1968	undecaprenyl-diphosphatase activity
EWA65_RS00800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EWA65_RS00805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EWA65_RS00810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EWA65_RS00815	COG0585	pseudouridine synthase activity
EWA65_RS00820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EWA65_RS00825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EWA65_RS00835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EWA65_RS00840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EWA65_RS00850	COG4150	thiosulfate binding
EWA65_RS00860	COG4208	sulfate ABC transporter
EWA65_RS00865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EWA65_RS00875	COG1546	Belongs to the CinA family
EWA65_RS00880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EWA65_RS00885	COG2137	regulation of response to DNA damage stimulus
EWA65_RS00890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EWA65_RS00895	COG0527	aspartate kinase activity
EWA65_RS00900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EWA65_RS00945	COG3630	sodium ion export across plasma membrane
EWA65_RS00950	COG0511	ligase activity, forming carbon-carbon bonds
EWA65_RS00950	COG5016	pyruvate
EWA65_RS00955	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EWA65_RS00965	COG1238	metal cluster binding
EWA65_RS00970	COG0612	Peptidase, M16
EWA65_RS00980	COG1854	S-ribosylhomocysteine lyase activity
EWA65_RS00985	COG4536	flavin adenine dinucleotide binding
EWA65_RS00990	COG4137	Cytochrome C assembly protein
EWA65_RS00995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EWA65_RS01000	COG0228	four-way junction DNA binding
EWA65_RS01005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EWA65_RS01010	COG0336	Belongs to the RNA methyltransferase TrmD family
EWA65_RS01015	COG0335	large ribosomal subunit rRNA binding
EWA65_RS01020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWA65_RS01025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWA65_RS01035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EWA65_RS01040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EWA65_RS01045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EWA65_RS01050	COG0723	plastoquinol--plastocyanin reductase activity
EWA65_RS01055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EWA65_RS01060	COG2857	Cytochrome c1
EWA65_RS01065	COG0625	glutathione transferase activity
EWA65_RS01070	COG2969	positive regulation of protein catabolic process
EWA65_RS01075	COG2823	Periplasmic or secreted lipoprotein
EWA65_RS01080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EWA65_RS01085	COG0792	nuclease activity
EWA65_RS01090	COG3107	peptidoglycan biosynthetic process
EWA65_RS01095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EWA65_RS01110	COG0288	reversible hydration of carbon dioxide
EWA65_RS01115	COG0659	secondary active sulfate transmembrane transporter activity
EWA65_RS01120	COG1131	(ABC) transporter
EWA65_RS01125	COG0842	Transport permease protein
EWA65_RS01130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EWA65_RS01135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EWA65_RS01140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EWA65_RS01155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EWA65_RS01160	COG1489	DNA binding
EWA65_RS01170	COG1643	Atp-dependent helicase
EWA65_RS01175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EWA65_RS01180	COG1752	Esterase of the alpha-beta hydrolase superfamily
EWA65_RS01190	COG3112	Uncharacterised protein family (UPF0231)
EWA65_RS01195	COG0347	Belongs to the P(II) protein family
EWA65_RS01200	COG0004	ammonium transporteR
EWA65_RS01205	COG1840	ABC-type Fe3 transport system, periplasmic component
EWA65_RS01215	COG3842	ATPase activity
EWA65_RS01235	COG2971	BadF BadG BcrA BcrD
EWA65_RS01245	COG4608	Belongs to the ABC transporter superfamily
EWA65_RS01250	COG0444	Belongs to the ABC transporter superfamily
EWA65_RS01255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA65_RS01265	COG0747	negative chemotaxis
EWA65_RS01270	COG0784	Response regulator, receiver
EWA65_RS01270	COG2205	protein histidine kinase activity
EWA65_RS01275	COG2813	Specifically methylates the guanine in position
EWA65_RS01280	COG0628	permease
EWA65_RS01290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EWA65_RS01295	COG0316	Belongs to the HesB IscA family
EWA65_RS01305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWA65_RS01310	COG0739	heme binding
EWA65_RS01315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EWA65_RS01320	COG2027	D-alanyl-D-alanine carboxypeptidase
EWA65_RS01325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EWA65_RS01330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EWA65_RS01335	COG1534	Rna-binding protein
EWA65_RS01340	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EWA65_RS01345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EWA65_RS01350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EWA65_RS01360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EWA65_RS01375	COG0779	Required for maturation of 30S ribosomal subunits
EWA65_RS01380	COG0195	Participates in both transcription termination and antitermination
EWA65_RS01385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EWA65_RS01390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EWA65_RS01400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EWA65_RS01425	COG0826	peptidase U32
EWA65_RS01430	COG0826	peptidase U32
EWA65_RS01440	COG3154	lipid carrier protein
EWA65_RS01445	COG3153	acetyltransferase
EWA65_RS01470	COG0513	Belongs to the DEAD box helicase family
EWA65_RS01490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EWA65_RS01495	COG2204	response regulator
EWA65_RS01505	COG0667	Aldo Keto reductase
EWA65_RS01510	COG3066	DNA modification
EWA65_RS01515	COG0494	nUDIX hydrolase
EWA65_RS01520	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EWA65_RS01525	COG0730	response to heat
EWA65_RS01530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EWA65_RS01535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EWA65_RS01540	COG1283	sodium-dependent phosphate transmembrane transporter activity
EWA65_RS01545	COG0583	DNA-binding transcription factor activity
EWA65_RS01550	COG0640	Transcriptional regulator
EWA65_RS01555	COG0268	Binds directly to 16S ribosomal RNA
EWA65_RS01560	COG0728	peptidoglycan biosynthetic process
EWA65_RS01565	COG0196	riboflavin kinase activity
EWA65_RS01575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EWA65_RS01580	COG1047	Peptidyl-prolyl cis-trans
EWA65_RS01585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EWA65_RS01590	COG1966	Carbon starvation protein
EWA65_RS01605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EWA65_RS01620	COG3279	Response regulator of the LytR AlgR family
EWA65_RS01625	COG3275	phosphorelay sensor kinase activity
EWA65_RS01630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EWA65_RS01635	COG0287	Prephenate dehydrogenase
EWA65_RS01635	COG1605	Chorismate mutase
EWA65_RS01645	COG0488	(ABC) transporter
EWA65_RS01655	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EWA65_RS01665	COG5001	Diguanylate cyclase
EWA65_RS01670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EWA65_RS01675	COG1605	Chorismate mutase
EWA65_RS01675	COG0077	Prephenate dehydratase
EWA65_RS01680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EWA65_RS01685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWA65_RS01690	COG0564	pseudouridine synthase activity
EWA65_RS01695	COG1496	oxidoreductase activity
EWA65_RS01700	COG0542	response to heat
EWA65_RS01740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EWA65_RS01745	COG0826	peptidase U32
EWA65_RS01755	COG0745	RESPONSE REGULATOR receiver
EWA65_RS01760	COG5002	protein histidine kinase activity
EWA65_RS01770	COG0248	Ppx GppA phosphatase
EWA65_RS01775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EWA65_RS01780	COG0573	inorganic phosphate transmembrane transporter activity
EWA65_RS01785	COG0581	inorganic phosphate transmembrane transporter activity
EWA65_RS01805	COG3142	Participates in the control of copper homeostasis
EWA65_RS01810	COG0450	alkyl hydroperoxide reductase
EWA65_RS01815	COG0583	DNA-binding transcription factor activity
EWA65_RS01820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EWA65_RS01830	COG0517	IMP dehydrogenase activity
EWA65_RS01850	COG1862	Preprotein translocase
EWA65_RS01855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWA65_RS01860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWA65_RS01865	COG0483	inositol monophosphate 1-phosphatase activity
EWA65_RS01870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EWA65_RS01875	COG1959	2 iron, 2 sulfur cluster binding
EWA65_RS01885	COG0822	iron-sulfur transferase activity
EWA65_RS01895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EWA65_RS01905	COG0633	Ferredoxin
EWA65_RS01910	COG2975	iron-sulfur cluster assembly
EWA65_RS01915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EWA65_RS01920	COG0105	UTP biosynthetic process
EWA65_RS01925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EWA65_RS01930	COG1426	Protein conserved in bacteria
EWA65_RS01935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EWA65_RS01940	COG0124	histidyl-tRNA synthetase
EWA65_RS01945	COG2976	Protein conserved in bacteria
EWA65_RS01950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWA65_RS01955	COG1160	GTP binding
EWA65_RS01960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EWA65_RS01970	COG1570	exodeoxyribonuclease VII activity
EWA65_RS01975	COG0516	GMP reductase activity
EWA65_RS01975	COG0517	IMP dehydrogenase activity
EWA65_RS01980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EWA65_RS01980	COG0519	Catalyzes the synthesis of GMP from XMP
EWA65_RS01990	COG1584	GPR1 FUN34 yaaH family protein
EWA65_RS01995	COG0583	DNA-binding transcription factor activity
EWA65_RS02000	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EWA65_RS02005	COG1115	amino acid carrier protein
EWA65_RS02015	COG0583	DNA-binding transcription factor activity
EWA65_RS02030	COG4565	transcriptional regulatory protein
EWA65_RS02040	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EWA65_RS02045	COG5016	pyruvate
EWA65_RS02045	COG0511	ligase activity, forming carbon-carbon bonds
EWA65_RS02050	COG3630	sodium ion export across plasma membrane
EWA65_RS02060	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EWA65_RS02065	COG3052	prosthetic group binding
EWA65_RS02070	COG2301	Belongs to the HpcH HpaI aldolase family
EWA65_RS02075	COG3051	citrate lyase alpha subunit
EWA65_RS02090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EWA65_RS02095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EWA65_RS02100	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EWA65_RS02140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EWA65_RS02145	COG2867	negative regulation of translational initiation
EWA65_RS02150	COG2914	Belongs to the UPF0125 (RnfH) family
EWA65_RS02155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWA65_RS02160	COG0497	DNA recombination
EWA65_RS02165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EWA65_RS02170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EWA65_RS02175	COG0443	Heat shock 70 kDa protein
EWA65_RS02180	COG0484	heat shock protein binding
EWA65_RS02210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EWA65_RS02220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EWA65_RS02230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EWA65_RS02230	COG0047	phosphoribosylformylglycinamidine synthase activity
EWA65_RS02250	COG0442	prolyl-tRNA aminoacylation
EWA65_RS02255	COG1720	tRNA m6t6A37 methyltransferase activity
EWA65_RS02260	COG0254	rRNA binding
EWA65_RS02265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EWA65_RS02270	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EWA65_RS02275	COG1671	Belongs to the UPF0178 family
EWA65_RS02305	COG0564	pseudouridine synthase activity
EWA65_RS02310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EWA65_RS02315	COG0142	geranyltranstransferase activity
EWA65_RS02320	COG1722	exodeoxyribonuclease VII activity
EWA65_RS02325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EWA65_RS02335	COG0301	tRNA thio-modification
EWA65_RS02335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EWA65_RS02340	COG0583	DNA-binding transcription factor activity
EWA65_RS02345	COG2363	Small membrane protein
EWA65_RS02350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWA65_RS02355	COG1611	Belongs to the LOG family
EWA65_RS02370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EWA65_RS02370	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EWA65_RS02380	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EWA65_RS02385	COG1464	Belongs to the NlpA lipoprotein family
EWA65_RS02390	COG2011	ABC-type metal ion transport system permease component
EWA65_RS02395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EWA65_RS02400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EWA65_RS02405	COG1609	Transcriptional regulator
EWA65_RS02410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA65_RS02410	COG1263	PTS System
EWA65_RS02440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWA65_RS02450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EWA65_RS02455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EWA65_RS02460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EWA65_RS02500	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EWA65_RS02530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EWA65_RS02540	COG1596	polysaccharide export
EWA65_RS02565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EWA65_RS02575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EWA65_RS02580	COG0321	lipoyl(octanoyl) transferase activity
EWA65_RS02585	COG2921	Belongs to the UPF0250 family
EWA65_RS02595	COG1686	Belongs to the peptidase S11 family
EWA65_RS02600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EWA65_RS02605	COG0772	Belongs to the SEDS family
EWA65_RS02610	COG0768	penicillin binding
EWA65_RS02615	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EWA65_RS02620	COG0799	negative regulation of ribosome biogenesis
EWA65_RS02625	COG1466	dna polymerase III delta subunit
EWA65_RS02630	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EWA65_RS02635	COG0495	leucyl-tRNA aminoacylation
EWA65_RS02640	COG2888	peptidyl-tyrosine sulfation
EWA65_RS02645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EWA65_RS02650	COG4535	Mg2 and Co2 transporter CorC
EWA65_RS02655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EWA65_RS02660	COG1702	phosphate starvation-inducible protein PhoH
EWA65_RS02665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EWA65_RS02670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWA65_RS02675	COG2190	(PTS) system
EWA65_RS02685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA65_RS02695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EWA65_RS02700	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EWA65_RS02705	COG3115	cell septum assembly
EWA65_RS02710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EWA65_RS02725	COG0789	Transcriptional regulator
EWA65_RS02730	COG1585	Membrane protein implicated in regulation of membrane protease activity
EWA65_RS02735	COG0330	HflC and HflK could
EWA65_RS02740	COG3118	belongs to the thioredoxin family
EWA65_RS02750	COG0300	oxidoreductase activity
EWA65_RS02755	COG1090	epimerase
EWA65_RS02760	COG0622	Phosphoesterase
EWA65_RS02775	COG3710	Transcriptional regulator
EWA65_RS02780	COG0326	Molecular chaperone. Has ATPase activity
EWA65_RS02785	COG0563	adenylate kinase activity
EWA65_RS02790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EWA65_RS02795	COG3104	oligopeptide transport
EWA65_RS02800	COG0250	Participates in transcription elongation, termination and antitermination
EWA65_RS02805	COG0367	asparagine synthase
EWA65_RS02810	COG4651	solute:proton antiporter activity
EWA65_RS02810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EWA65_RS02815	COG1940	carbohydrate kinase activity
EWA65_RS02815	COG1846	Transcriptional regulator
EWA65_RS02820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EWA65_RS02825	COG1263	PTS System
EWA65_RS02825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA65_RS02825	COG2190	(PTS) system
EWA65_RS02840	COG0101	tRNA pseudouridine synthase activity
EWA65_RS02845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EWA65_RS02850	COG0285	dihydrofolate synthase activity
EWA65_RS02855	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EWA65_RS02860	COG1286	toxin biosynthetic process
EWA65_RS02865	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EWA65_RS02870	COG2056	Na+-H+ antiporter family
EWA65_RS02875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EWA65_RS02885	COG0346	lactoylglutathione lyase activity
EWA65_RS02890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EWA65_RS02895	COG4660	Part of a membrane complex involved in electron transport
EWA65_RS02905	COG4658	electron transport chain
EWA65_RS02910	COG4656	Part of a membrane complex involved in electron transport
EWA65_RS02915	COG2878	Part of a membrane complex involved in electron transport
EWA65_RS02920	COG4657	Part of a membrane complex involved in electron transport
EWA65_RS02930	COG0556	nucleotide-excision repair
EWA65_RS02935	COG2204	response regulator
EWA65_RS02940	COG2198	Histidine kinase
EWA65_RS02945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EWA65_RS02950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EWA65_RS02955	COG0521	Mo-molybdopterin cofactor biosynthetic process
EWA65_RS02960	COG0315	cyclic pyranopterin monophosphate synthase activity
EWA65_RS02965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EWA65_RS02970	COG0314	molybdopterin synthase activity
EWA65_RS02975	COG2199	diguanylate cyclase activity
EWA65_RS02980	COG0617	tRNA 3'-terminal CCA addition
EWA65_RS02980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EWA65_RS02980	COG0517	IMP dehydrogenase activity
EWA65_RS02990	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EWA65_RS03000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWA65_RS03000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWA65_RS03005	COG0489	protein tyrosine kinase activity
EWA65_RS03010	COG0572	uridine kinase
EWA65_RS03015	COG2982	Protein involved in outer membrane biogenesis
EWA65_RS03020	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EWA65_RS03025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EWA65_RS03030	COG2067	long-chain fatty acid transport protein
EWA65_RS03035	COG2067	long-chain fatty acid transport protein
EWA65_RS03050	COG0183	Belongs to the thiolase family
EWA65_RS03055	COG1250	3-hydroxyacyl-CoA dehydrogenase
EWA65_RS03055	COG1024	Enoyl-CoA hydratase
EWA65_RS03060	COG0778	Nitroreductase
EWA65_RS03065	COG0583	DNA-binding transcription factor activity
EWA65_RS03070	COG0745	RESPONSE REGULATOR receiver
EWA65_RS03080	COG2832	Protein of unknown function (DUF454)
EWA65_RS03085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EWA65_RS03090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EWA65_RS03095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EWA65_RS03100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EWA65_RS03110	COG2983	Belongs to the UPF0260 family
EWA65_RS03115	COG1028	Short-chain dehydrogenase reductase Sdr
EWA65_RS03120	COG0616	signal peptide processing
EWA65_RS03130	COG1522	sequence-specific DNA binding
EWA65_RS03135	COG1946	Acyl-CoA thioesterase
EWA65_RS03155	COG3300	MHYT domain
EWA65_RS03155	COG5001	Diguanylate cyclase
EWA65_RS03165	COG0640	Transcriptional regulator
EWA65_RS03170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EWA65_RS03185	COG1349	DNA-binding transcription factor activity
EWA65_RS03190	COG1349	DNA-binding transcription factor activity
EWA65_RS03200	COG2222	sugar isomerase
EWA65_RS03205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA65_RS03215	COG3716	PTS system mannose fructose sorbose family IID component
EWA65_RS03245	COG1881	PFAM PEBP family protein
EWA65_RS03265	COG0009	L-threonylcarbamoyladenylate synthase
EWA65_RS03280	COG2201	protein-glutamate methylesterase activity
EWA65_RS03290	COG5002	protein histidine kinase activity
EWA65_RS03295	COG4191	Histidine kinase
EWA65_RS03300	COG3300	MHYT domain
EWA65_RS03300	COG5001	Diguanylate cyclase
EWA65_RS03305	COG2204	response regulator
EWA65_RS03310	COG4191	Histidine kinase
EWA65_RS03325	COG0601	transmembrane transport
EWA65_RS03330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA65_RS03335	COG0444	Belongs to the ABC transporter superfamily
EWA65_RS03345	COG0435	Glutathione S-transferase
EWA65_RS03350	COG0280	phosphate acetyltransferase
EWA65_RS03350	COG0857	belongs to the CobB CobQ family
EWA65_RS03355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EWA65_RS03360	COG3092	negative regulation of chromosome organization
EWA65_RS03365	COG4628	conserved protein (DUF2132)
EWA65_RS03375	COG4120	Belongs to the binding-protein-dependent transport system permease family
EWA65_RS03385	COG3706	GGDEF domain
EWA65_RS03390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EWA65_RS03395	COG0653	protein targeting
EWA65_RS03400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EWA65_RS03405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EWA65_RS03410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EWA65_RS03415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EWA65_RS03420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EWA65_RS03425	COG0156	8-amino-7-oxononanoate synthase activity
EWA65_RS03430	COG2226	methyltransferase
EWA65_RS03435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EWA65_RS03445	COG0501	Belongs to the peptidase M48B family
EWA65_RS03455	COG0300	oxidoreductase activity
EWA65_RS03470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EWA65_RS03480	COG2268	Band 7 protein
EWA65_RS03490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EWA65_RS03495	COG2915	High frequency lysogenization protein hflD homolog
EWA65_RS03500	COG0482	sulfurtransferase activity
EWA65_RS03505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA65_RS03510	COG2916	Histone family protein nucleoid-structuring protein H-NS
EWA65_RS03515	COG1757	Na H antiporter
EWA65_RS03520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EWA65_RS03525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EWA65_RS03530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EWA65_RS03535	COG0131	Imidazoleglycerol-phosphate dehydratase
EWA65_RS03535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EWA65_RS03540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EWA65_RS03545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EWA65_RS03550	COG0107	imidazoleglycerol-phosphate synthase activity
EWA65_RS03555	COG0140	phosphoribosyl-ATP diphosphatase activity
EWA65_RS03555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EWA65_RS03560	COG1187	pseudouridine synthase activity
EWA65_RS03570	COG1278	Cold shock
EWA65_RS03575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EWA65_RS03580	COG0542	response to heat
EWA65_RS03585	COG2985	domain, Protein
EWA65_RS03585	COG3273	potassium ion transport
EWA65_RS03590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EWA65_RS03595	COG1012	belongs to the aldehyde dehydrogenase family
EWA65_RS03595	COG1454	alcohol dehydrogenase
EWA65_RS03600	COG1737	Transcriptional regulator
EWA65_RS03605	COG0076	glutamate decarboxylase activity
EWA65_RS03615	COG2431	L-lysine efflux transmembrane transporter activity
EWA65_RS03625	COG3070	regulator of competence-specific genes
EWA65_RS03640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA65_RS03640	COG4191	Histidine kinase
EWA65_RS03650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EWA65_RS03665	COG4067	protein conserved in archaea
EWA65_RS03665	COG0189	ligase activity
EWA65_RS03670	COG0500	methyltransferase
EWA65_RS03675	COG4106	trans-aconitate 2-methyltransferase activity
EWA65_RS03680	COG1801	Protein of unknown function DUF72
EWA65_RS03685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EWA65_RS03690	COG1435	thymidine kinase activity
EWA65_RS03695	COG1301	dicarboxylic acid transport
EWA65_RS03700	COG0159	tryptophan synthase activity
EWA65_RS03705	COG0133	tryptophan synthase activity
EWA65_RS03710	COG0134	indole-3-glycerol-phosphate synthase activity
EWA65_RS03710	COG0135	phosphoribosylanthranilate isomerase activity
EWA65_RS03715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EWA65_RS03720	COG0512	Glutamine amidotransferase of anthranilate synthase
EWA65_RS03725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EWA65_RS03735	COG0613	PHP domain protein
EWA65_RS03740	COG0009	L-threonylcarbamoyladenylate synthase
EWA65_RS03745	COG1187	pseudouridine synthase activity
EWA65_RS03750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EWA65_RS03760	COG0492	ferredoxin-NADP+ reductase activity
EWA65_RS03775	COG3706	GGDEF domain
EWA65_RS03780	COG2949	membrane
EWA65_RS03790	COG0281	malic enzyme
EWA65_RS03800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EWA65_RS03820	COG2885	chlorophyll binding
EWA65_RS03835	COG0247	lactate metabolic process
EWA65_RS03835	COG0277	FAD linked oxidase domain protein
EWA65_RS03855	COG2986	histidine ammonia-lyase
EWA65_RS03860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EWA65_RS03865	COG0010	Belongs to the arginase family
EWA65_RS03870	COG1228	amidohydrolase
EWA65_RS03880	COG3099	Belongs to the UPF0263 family
EWA65_RS03885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EWA65_RS03895	COG5001	Diguanylate cyclase
EWA65_RS03900	COG0417	DNA replication proofreading
EWA65_RS03905	COG2197	response regulator
EWA65_RS03910	COG0322	excinuclease ABC activity
EWA65_RS03945	COG0456	acetyltransferase
EWA65_RS03950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EWA65_RS03955	COG0072	phenylalanine-tRNA ligase activity
EWA65_RS03955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWA65_RS03960	COG0776	regulation of translation
EWA65_RS03990	COG1346	cytolysis
EWA65_RS03995	COG1380	Effector of murein hydrolase LrgA
EWA65_RS04000	COG2925	Exonuclease
EWA65_RS04005	COG1823	symporter activity
EWA65_RS04010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWA65_RS04015	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EWA65_RS04020	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EWA65_RS04035	COG2988	succinylglutamate desuccinylase activity
EWA65_RS04040	COG4139	cobalamin transport
EWA65_RS04045	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EWA65_RS04095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EWA65_RS04100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EWA65_RS04115	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EWA65_RS04125	COG0437	4 iron, 4 sulfur cluster binding
EWA65_RS04130	COG3301	Polysulphide reductase, NrfD
EWA65_RS04135	COG1138	Cytochrome C-type biogenesis protein
EWA65_RS04145	COG4235	cytochrome complex assembly
EWA65_RS04145	COG3088	subunit of a heme lyase
EWA65_RS04155	COG1278	Cold shock
EWA65_RS04160	COG1054	Belongs to the UPF0176 family
EWA65_RS04170	COG2814	Major facilitator Superfamily
EWA65_RS04180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EWA65_RS04215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWA65_RS04230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EWA65_RS04255	COG1846	Transcriptional regulator
EWA65_RS04260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EWA65_RS04265	COG0726	polysaccharide deacetylase
EWA65_RS04270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EWA65_RS04280	COG1447	Phosphotransferase system cellobiose-specific component IIA
EWA65_RS04285	COG1486	melibiose metabolic process
EWA65_RS04290	COG3394	polysaccharide catabolic process
EWA65_RS04295	COG1609	Transcriptional regulator
EWA65_RS04300	COG2943	transferase activity, transferring hexosyl groups
EWA65_RS04305	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EWA65_RS04310	COG0840	transmembrane signaling receptor activity
EWA65_RS04325	COG1448	Aminotransferase
EWA65_RS04330	COG0110	maltose O-acetyltransferase activity
EWA65_RS04335	COG0351	phosphomethylpyrimidine kinase
EWA65_RS04340	COG0017	Asparaginyl-tRNA synthetase
EWA65_RS04350	COG0720	synthase
EWA65_RS04355	COG1760	l-serine dehydratase
EWA65_RS04360	COG0814	amino acid
EWA65_RS04365	COG0494	nUDIX hydrolase
EWA65_RS04370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EWA65_RS04385	COG3106	COG3106 Predicted ATPase
EWA65_RS04390	COG3768	UPF0283 membrane protein
EWA65_RS04400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA65_RS04420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EWA65_RS04430	COG0471	metal ion transport
EWA65_RS04435	COG4191	Histidine kinase
EWA65_RS04435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA65_RS04445	COG2990	Protein conserved in bacteria
EWA65_RS04450	COG3713	MltA-interacting MipA family protein
EWA65_RS04455	COG5002	protein histidine kinase activity
EWA65_RS04460	COG0745	RESPONSE REGULATOR receiver
EWA65_RS04485	COG1129	ABC transporter
EWA65_RS04520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EWA65_RS04525	COG2186	Transcriptional regulator
EWA65_RS04530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EWA65_RS04535	COG0372	Belongs to the citrate synthase family
EWA65_RS04620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EWA65_RS04645	COG2195	Cleaves the N-terminal amino acid of tripeptides
EWA65_RS04655	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EWA65_RS04665	COG0625	glutathione transferase activity
EWA65_RS04670	COG3437	response regulator, receiver
EWA65_RS04685	COG3706	GGDEF domain
EWA65_RS04690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EWA65_RS04700	COG1254	Belongs to the acylphosphatase family
EWA65_RS04705	COG2920	part of a sulfur-relay system
EWA65_RS04710	COG0670	Belongs to the BI1 family
EWA65_RS04715	COG1126	abc transporter atp-binding protein
EWA65_RS04720	COG0765	amino acid transport
EWA65_RS04725	COG4597	amino acid ABC transporter
EWA65_RS04730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA65_RS04740	COG0561	phosphatase activity
EWA65_RS04745	COG0602	queuosine metabolic process
EWA65_RS04750	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EWA65_RS04765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EWA65_RS04780	COG3706	GGDEF domain
EWA65_RS04790	COG0443	Heat shock 70 kDa protein
EWA65_RS04800	COG3706	GGDEF domain
EWA65_RS04825	COG1643	Atp-dependent helicase
EWA65_RS04840	COG0840	transmembrane signaling receptor activity
EWA65_RS04845	COG3250	beta-galactosidase activity
EWA65_RS04850	COG0402	S-adenosylhomocysteine deaminase activity
EWA65_RS04855	COG0443	Heat shock 70 kDa protein
EWA65_RS04860	COG0095	Lipoate-protein ligase
EWA65_RS04870	COG0583	DNA-binding transcription factor activity
EWA65_RS04875	COG0477	Major facilitator Superfamily
EWA65_RS04890	COG0745	RESPONSE REGULATOR receiver
EWA65_RS04900	COG0643	Histidine kinase
EWA65_RS04900	COG2198	Histidine kinase
EWA65_RS04905	COG0643	Histidine kinase
EWA65_RS04905	COG0784	Response regulator, receiver
EWA65_RS04905	COG2198	Histidine kinase
EWA65_RS04910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EWA65_RS04920	COG2201	protein-glutamate methylesterase activity
EWA65_RS04925	COG0835	chemotaxis
EWA65_RS04930	COG0840	transmembrane signaling receptor activity
EWA65_RS04935	COG0840	transmembrane signaling receptor activity
EWA65_RS04945	COG0513	Belongs to the DEAD box helicase family
EWA65_RS04955	COG1538	Outer membrane efflux protein
EWA65_RS04960	COG1566	PFAM secretion protein HlyD family protein
EWA65_RS04965	COG2814	Major facilitator Superfamily
EWA65_RS04975	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EWA65_RS04985	COG3501	Rhs element vgr protein
EWA65_RS05005	COG1280	lysine exporter protein (LysE YggA)
EWA65_RS05010	COG1115	amino acid carrier protein
EWA65_RS05025	COG3385	transposase activity
EWA65_RS05040	COG1177	transmembrane transport
EWA65_RS05050	COG3842	ATPase activity
EWA65_RS05070	COG0037	tRNA processing
EWA65_RS05075	COG0589	response to stress
EWA65_RS05080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWA65_RS05095	COG2217	Heavy metal translocating P-type atpase
EWA65_RS05105	COG2010	Cytochrome c
EWA65_RS05120	COG3278	Belongs to the heme-copper respiratory oxidase family
EWA65_RS05135	COG2205	protein histidine kinase activity
EWA65_RS05135	COG0784	Response regulator, receiver
EWA65_RS05150	COG3120	sequence-specific DNA binding
EWA65_RS05155	COG1067	ATP-dependent peptidase activity
EWA65_RS05160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EWA65_RS05175	COG0488	(ABC) transporter
EWA65_RS05185	COG0116	Belongs to the methyltransferase superfamily
EWA65_RS05185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EWA65_RS05195	COG0167	dihydroorotate dehydrogenase activity
EWA65_RS05200	COG2902	Dehydrogenase
EWA65_RS05210	COG0308	aminopeptidase N
EWA65_RS05225	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EWA65_RS05230	COG1956	GAF domain-containing protein
EWA65_RS05235	COG1132	(ABC) transporter
EWA65_RS05240	COG2995	paraquat-inducible protein a
EWA65_RS05245	COG3008	intermembrane lipid transfer
EWA65_RS05255	COG2996	Protein conserved in bacteria
EWA65_RS05270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EWA65_RS05275	COG1666	GTP binding
EWA65_RS05280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EWA65_RS05285	COG0004	ammonium transporteR
EWA65_RS05300	COG0437	4 iron, 4 sulfur cluster binding
EWA65_RS05305	COG0243	molybdopterin cofactor binding
EWA65_RS05305	COG3383	formate dehydrogenase (NAD+) activity
EWA65_RS05335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EWA65_RS05340	COG0488	(ABC) transporter
EWA65_RS05345	COG3852	Histidine kinase
EWA65_RS05350	COG2204	response regulator
EWA65_RS05360	COG4662	Binding-protein-dependent transport system inner membrane component
EWA65_RS05365	COG3842	ATPase activity
EWA65_RS05370	COG0746	molybdenum cofactor guanylyltransferase activity
EWA65_RS05385	COG1940	carbohydrate kinase activity
EWA65_RS05390	COG3148	PFAM DTW domain containing protein
EWA65_RS05400	COG0840	transmembrane signaling receptor activity
EWA65_RS05405	COG0791	NLP P60 protein
EWA65_RS05415	COG3001	Fructosamine kinase
EWA65_RS05425	COG0534	Mate efflux family protein
EWA65_RS05435	COG1793	dna ligase
EWA65_RS05450	COG0848	biopolymer transport protein
EWA65_RS05455	COG0811	peptide transport
EWA65_RS05460	COG0811	peptide transport
EWA65_RS05475	COG1175	transmembrane transport
EWA65_RS05480	COG0395	ABC-type sugar transport system, permease component
EWA65_RS05485	COG3842	ATPase activity
EWA65_RS05490	COG1349	DNA-binding transcription factor activity
EWA65_RS05495	COG0584	glycerophosphoryl diester phosphodiesterase
EWA65_RS05500	COG2731	YhcH YjgK YiaL family protein
EWA65_RS05505	COG0251	oxidation-reduction process
EWA65_RS05510	COG1609	Transcriptional regulator
EWA65_RS05515	COG2723	6-phospho-beta-galactosidase activity
EWA65_RS05545	COG0577	efflux transmembrane transporter activity
EWA65_RS05545	COG1136	(ABC) transporter
EWA65_RS05550	COG1136	(ABC) transporter
EWA65_RS05550	COG0577	efflux transmembrane transporter activity
EWA65_RS05555	COG4591	ABC-type transport system involved in lipoprotein release permease component
EWA65_RS05555	COG1136	(ABC) transporter
EWA65_RS05560	COG1294	oxidase, subunit
EWA65_RS05565	COG1271	oxidase subunit
EWA65_RS05590	COG3097	Belongs to the UPF0267 family
EWA65_RS05605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EWA65_RS05620	COG0753	catalase activity
EWA65_RS05645	COG0493	'glutamate synthase
EWA65_RS05655	COG0398	Pfam SNARE associated Golgi protein
EWA65_RS05660	COG4135	transport system, permease component
EWA65_RS05665	COG2199	diguanylate cyclase activity
EWA65_RS05665	COG2200	EAL domain
EWA65_RS05675	COG2017	converts alpha-aldose to the beta-anomer
EWA65_RS05680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EWA65_RS05685	COG1085	galactose-1-phosphate uridylyltransferase
EWA65_RS05720	COG0784	Response regulator, receiver
EWA65_RS05720	COG0835	chemotaxis
EWA65_RS05730	COG4565	transcriptional regulatory protein
EWA65_RS05735	COG3290	protein histidine kinase activity
EWA65_RS05750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWA65_RS05770	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EWA65_RS05775	COG3063	Type IV pilus biogenesis stability protein PilW
EWA65_RS05790	COG1451	nucleotide metabolic process
EWA65_RS05800	COG0583	DNA-binding transcription factor activity
EWA65_RS05820	COG1538	Outer membrane efflux protein
EWA65_RS05835	COG1748	Saccharopine dehydrogenase
EWA65_RS05845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EWA65_RS05855	COG0577	efflux transmembrane transporter activity
EWA65_RS05860	COG4181	ATPase activity
EWA65_RS05865	COG0534	Mate efflux family protein
EWA65_RS05870	COG0702	epimerase
EWA65_RS05880	COG2814	Major facilitator Superfamily
EWA65_RS05885	COG1187	pseudouridine synthase activity
EWA65_RS05890	COG1061	Type III restriction enzyme res subunit
EWA65_RS05910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EWA65_RS05925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA65_RS05955	COG4934	collagen metabolic process
EWA65_RS05970	COG2205	protein histidine kinase activity
EWA65_RS05970	COG0784	Response regulator, receiver
EWA65_RS05975	COG2239	Acts as a magnesium transporter
EWA65_RS05985	COG0814	amino acid
EWA65_RS05995	COG1131	(ABC) transporter
EWA65_RS06000	COG0842	Transport permease protein
EWA65_RS06010	COG3313	Fe-S protein
EWA65_RS06020	COG4134	Bacterial extracellular solute-binding protein
EWA65_RS06025	COG4135	transport system, permease component
EWA65_RS06030	COG4136	ATPase activity
EWA65_RS06035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EWA65_RS06040	COG0564	pseudouridine synthase activity
EWA65_RS06045	COG0733	neurotransmitter:sodium symporter activity
EWA65_RS06055	COG0626	cystathionine gamma-synthase activity
EWA65_RS06060	COG2818	Glycosylase
EWA65_RS06075	COG1842	Phage shock protein A
EWA65_RS06080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EWA65_RS06105	COG4172	Belongs to the ABC transporter superfamily
EWA65_RS06125	COG1227	inorganic diphosphatase activity
EWA65_RS06130	COG1162	GTPase activity
EWA65_RS06145	COG0243	molybdopterin cofactor binding
EWA65_RS06150	COG3005	denitrification pathway
EWA65_RS06155	COG4459	periplasmic nitrate reductase
EWA65_RS06165	COG2116	formate transmembrane transporter activity
EWA65_RS06175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWA65_RS06180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EWA65_RS06205	COG2350	Protein conserved in bacteria
EWA65_RS06215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EWA65_RS06220	COG0583	DNA-binding transcription factor activity
EWA65_RS06235	COG0612	Peptidase, M16
EWA65_RS06240	COG2203	Gaf domain
EWA65_RS06240	COG2200	EAL domain
EWA65_RS06240	COG2199	diguanylate cyclase activity
EWA65_RS06245	COG1032	radical SAM domain protein
EWA65_RS06265	COG2207	Transcriptional regulator
EWA65_RS06270	COG1979	alcohol dehydrogenase
EWA65_RS06280	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EWA65_RS06285	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EWA65_RS06290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EWA65_RS06295	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EWA65_RS06300	COG0745	RESPONSE REGULATOR receiver
EWA65_RS06305	COG3381	protein complex oligomerization
EWA65_RS06310	COG1609	Transcriptional regulator
EWA65_RS06315	COG3070	regulator of competence-specific genes
EWA65_RS06335	COG0297	glycogen (starch) synthase activity
EWA65_RS06340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EWA65_RS06345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EWA65_RS06360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EWA65_RS06365	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EWA65_RS06370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EWA65_RS06375	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EWA65_RS06400	COG1012	belongs to the aldehyde dehydrogenase family
EWA65_RS06415	COG0668	transmembrane transport
EWA65_RS06420	COG2995	paraquat-inducible protein a
EWA65_RS06425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EWA65_RS06425	COG3008	intermembrane lipid transfer
EWA65_RS06445	COG2200	EAL domain
EWA65_RS06450	COG3385	transposase activity
EWA65_RS06460	COG2195	Cleaves the N-terminal amino acid of tripeptides
EWA65_RS06465	COG3069	C4-dicarboxylate transmembrane transporter activity
EWA65_RS06480	COG0745	RESPONSE REGULATOR receiver
EWA65_RS06490	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EWA65_RS06495	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EWA65_RS06505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EWA65_RS06515	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EWA65_RS06520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EWA65_RS06535	COG1940	carbohydrate kinase activity
EWA65_RS06540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EWA65_RS06545	COG4409	exo-alpha-(2->6)-sialidase activity
EWA65_RS06560	COG4628	conserved protein (DUF2132)
EWA65_RS06570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA65_RS06570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS06570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS06575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS06585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS06590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS06600	COG2207	Transcriptional regulator
EWA65_RS06605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA65_RS06605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS06605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS06620	COG0784	Response regulator, receiver
EWA65_RS06620	COG5002	protein histidine kinase activity
EWA65_RS06630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EWA65_RS06640	COG2885	chlorophyll binding
EWA65_RS06645	COG0823	Involved in the tonB-independent uptake of proteins
EWA65_RS06660	COG0811	peptide transport
EWA65_RS06665	COG0824	Thioesterase
EWA65_RS06670	COG3790	cyd operon protein YbgE
EWA65_RS06675	COG4890	Cyd operon protein YbgT
EWA65_RS06680	COG1294	oxidase, subunit
EWA65_RS06685	COG1271	oxidase subunit
EWA65_RS06695	COG0632	four-way junction helicase activity
EWA65_RS06700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EWA65_RS06705	COG0215	cysteine-tRNA ligase activity
EWA65_RS06710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EWA65_RS06715	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA65_RS06720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EWA65_RS06725	COG3012	SEC-C Motif Domain Protein
EWA65_RS06740	COG1199	ATP-dependent helicase activity
EWA65_RS06745	COG0730	response to heat
EWA65_RS06750	COG3923	Primosomal replication protein n
EWA65_RS06760	COG0840	transmembrane signaling receptor activity
EWA65_RS06765	COG0708	Exodeoxyribonuclease III
EWA65_RS06770	COG4160	amino acid transport
EWA65_RS06795	COG1882	Formate acetyltransferase
EWA65_RS06805	COG0840	transmembrane signaling receptor activity
EWA65_RS06810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EWA65_RS06820	COG3013	Belongs to the UPF0304 family
EWA65_RS06825	COG2766	serine protein kinase
EWA65_RS06830	COG2718	Belongs to the UPF0229 family
EWA65_RS06835	COG2719	SpoVR family
EWA65_RS06840	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EWA65_RS06845	COG2835	tetraacyldisaccharide 4'-kinase activity
EWA65_RS06850	COG1663	tetraacyldisaccharide 4'-kinase activity
EWA65_RS06855	COG1132	(ABC) transporter
EWA65_RS06860	COG0658	competence protein
EWA65_RS06860	COG2333	competence protein COMEC
EWA65_RS06870	COG4591	ABC-type transport system involved in lipoprotein release permease component
EWA65_RS06875	COG1136	(ABC) transporter
EWA65_RS06880	COG4591	ABC-type transport system involved in lipoprotein release permease component
EWA65_RS06890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EWA65_RS06910	COG1252	NADH dehydrogenase
EWA65_RS06915	COG3150	esterase
EWA65_RS06940	COG0537	adenosine 5'-monophosphoramidase activity
EWA65_RS06955	COG2186	Transcriptional regulator
EWA65_RS06960	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EWA65_RS06965	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EWA65_RS06970	COG3385	transposase activity
EWA65_RS06975	COG1674	ftsk spoiiie
EWA65_RS06980	COG1522	sequence-specific DNA binding
EWA65_RS06985	COG0686	Belongs to the AlaDH PNT family
EWA65_RS06995	COG0583	DNA-binding transcription factor activity
EWA65_RS07015	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EWA65_RS07020	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EWA65_RS07025	COG0776	regulation of translation
EWA65_RS07030	COG0539	negative regulation of cytoplasmic translation
EWA65_RS07035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EWA65_RS07040	COG1555	photosystem II stabilization
EWA65_RS07045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EWA65_RS07050	COG0776	regulation of translation
EWA65_RS07055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EWA65_RS07060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EWA65_RS07070	COG0544	peptidyl-prolyl cis-trans isomerase activity
EWA65_RS07080	COG4191	Histidine kinase
EWA65_RS07090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EWA65_RS07095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EWA65_RS07100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EWA65_RS07105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EWA65_RS07120	COG5001	Diguanylate cyclase
EWA65_RS07120	COG3300	MHYT domain
EWA65_RS07130	COG4589	Belongs to the CDS family
EWA65_RS07145	COG0671	phosphoesterase, PA-phosphatase related
EWA65_RS07160	COG3842	ATPase activity
EWA65_RS07205	COG1120	ATPase activity
EWA65_RS07210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EWA65_RS07220	COG4264	IucA IucC family
EWA65_RS07250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EWA65_RS07255	COG0243	molybdopterin cofactor binding
EWA65_RS07260	COG3005	denitrification pathway
EWA65_RS07265	COG3325	Belongs to the glycosyl hydrolase 18 family
EWA65_RS07265	COG3469	chitinase activity
EWA65_RS07270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EWA65_RS07280	COG2951	lytic endotransglycosylase activity
EWA65_RS07285	COG3100	YcgL domain-containing protein
EWA65_RS07290	COG0850	regulation of cytokinetic process
EWA65_RS07295	COG2894	cell division
EWA65_RS07300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EWA65_RS07305	COG3015	lipoprotein NlpE involved in copper resistance
EWA65_RS07325	COG0477	Major facilitator Superfamily
EWA65_RS07330	COG0840	transmembrane signaling receptor activity
EWA65_RS07335	COG1396	sequence-specific DNA binding
EWA65_RS07340	COG3135	benzoate transporter
EWA65_RS07360	COG0596	Alpha beta hydrolase
EWA65_RS07365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EWA65_RS07370	COG1169	isochorismate synthase
EWA65_RS07375	COG0436	Aminotransferase
EWA65_RS07380	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EWA65_RS07385	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EWA65_RS07400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EWA65_RS07405	COG0318	PFAM AMP-dependent synthetase and ligase
EWA65_RS07410	COG0596	Alpha beta hydrolase
EWA65_RS07425	COG1214	PFAM Peptidase M22, glycoprotease
EWA65_RS07430	COG1199	ATP-dependent helicase activity
EWA65_RS07440	COG0788	formyltetrahydrofolate deformylase activity
EWA65_RS07445	COG1902	pentaerythritol trinitrate reductase activity
EWA65_RS07445	COG0446	pyridine nucleotide-disulphide oxidoreductase
EWA65_RS07450	COG0616	signal peptide processing
EWA65_RS07455	COG0252	asparaginase activity
EWA65_RS07460	COG3139	Protein of unknown function (DUF1315)
EWA65_RS07470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWA65_RS07475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EWA65_RS07480	COG0676	glucose-6-phosphate 1-epimerase activity
EWA65_RS07490	COG2226	methyltransferase
EWA65_RS07520	COG0835	chemotaxis
EWA65_RS07520	COG0784	Response regulator, receiver
EWA65_RS07525	COG1940	carbohydrate kinase activity
EWA65_RS07535	COG4667	esterase of the alpha-beta hydrolase superfamily
EWA65_RS07550	COG0733	neurotransmitter:sodium symporter activity
EWA65_RS07565	COG1263	PTS System
EWA65_RS07565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA65_RS07570	COG0084	hydrolase, TatD family'
EWA65_RS07575	COG0470	DNA polymerase III
EWA65_RS07580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EWA65_RS07585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EWA65_RS07590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EWA65_RS07595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EWA65_RS07600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EWA65_RS07615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EWA65_RS07620	COG0416	fatty acid biosynthetic process
EWA65_RS07625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EWA65_RS07630	COG1399	metal-binding, possibly nucleic acid-binding protein
EWA65_RS07635	COG0424	maF-like protein
EWA65_RS07640	COG0564	pseudouridine synthase activity
EWA65_RS07645	COG1530	ribonuclease E activity
EWA65_RS07650	COG0659	secondary active sulfate transmembrane transporter activity
EWA65_RS07660	COG1454	alcohol dehydrogenase
EWA65_RS07660	COG1012	belongs to the aldehyde dehydrogenase family
EWA65_RS07665	COG2095	MarC family integral membrane protein
EWA65_RS07670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWA65_RS07680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EWA65_RS07685	COG1757	Na H antiporter
EWA65_RS07690	COG3385	transposase activity
EWA65_RS07700	COG3081	Nucleoid-associated protein
EWA65_RS07705	COG3082	Protein of unknown function (DUF1414)
EWA65_RS07710	COG3083	sulfuric ester hydrolase activity
EWA65_RS07725	COG0123	including yeast histone deacetylase and acetoin utilization protein
EWA65_RS07730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EWA65_RS07735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EWA65_RS07755	COG2853	Lipoprotein
EWA65_RS07765	COG3088	subunit of a heme lyase
EWA65_RS07765	COG4235	cytochrome complex assembly
EWA65_RS07770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EWA65_RS07775	COG1138	Cytochrome C-type biogenesis protein
EWA65_RS07780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EWA65_RS07790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EWA65_RS07795	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EWA65_RS07800	COG4133	protoheme IX ABC transporter activity
EWA65_RS07810	COG0835	chemotaxis
EWA65_RS07820	COG1192	Involved in chromosome partitioning
EWA65_RS07825	COG2201	protein-glutamate methylesterase activity
EWA65_RS07830	COG2198	Histidine kinase
EWA65_RS07830	COG0784	Response regulator, receiver
EWA65_RS07830	COG0643	Histidine kinase
EWA65_RS07835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EWA65_RS07865	COG2062	phosphohistidine phosphatase, SixA
EWA65_RS07870	COG1025	Belongs to the peptidase M16 family
EWA65_RS07880	COG0018	arginyl-trna synthetase
EWA65_RS07900	COG1918	ferrous iron import across plasma membrane
EWA65_RS07905	COG4977	sequence-specific DNA binding
EWA65_RS07910	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EWA65_RS07915	COG1121	(ABC) transporter
EWA65_RS07920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EWA65_RS07930	COG0045	succinate-CoA ligase (ADP-forming) activity
EWA65_RS07935	COG0508	dehydrogenase complex catalyzes the overall conversion of
EWA65_RS07940	COG0567	Dehydrogenase, E1 component
EWA65_RS07950	COG1053	succinate dehydrogenase
EWA65_RS07955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EWA65_RS07965	COG0372	Belongs to the citrate synthase family
EWA65_RS07975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EWA65_RS07985	COG0033	Phosphoglucomutase
EWA65_RS07990	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EWA65_RS07995	COG0596	Alpha beta hydrolase
EWA65_RS08010	COG1346	cytolysis
EWA65_RS08020	COG0583	DNA-binding transcription factor activity
EWA65_RS08030	COG0735	belongs to the Fur family
EWA65_RS08035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EWA65_RS08040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EWA65_RS08045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EWA65_RS08050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EWA65_RS08050	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EWA65_RS08055	COG0431	NADPH-dependent FMN reductase
EWA65_RS08065	COG3101	peptidyl-lysine hydroxylation
EWA65_RS08070	COG2860	membrane
EWA65_RS08075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EWA65_RS08080	COG2890	protein-(glutamine-N5) methyltransferase activity
EWA65_RS08085	COG2840	Smr protein MutS2
EWA65_RS08100	COG1987	bacterial-type flagellum assembly
EWA65_RS08145	COG1317	bacterial-type flagellum organization
EWA65_RS08150	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EWA65_RS08160	COG1677	Flagellar hook-basal body complex protein FliE
EWA65_RS08180	COG1516	flagellar protein fliS
EWA65_RS08190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EWA65_RS08195	COG1334	flagellar protein FlaG
EWA65_RS08200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA65_RS08205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA65_RS08210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA65_RS08215	COG2837	iron assimilation
EWA65_RS08235	COG1393	Belongs to the ArsC family
EWA65_RS08245	COG1876	peptidase activity
EWA65_RS08255	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EWA65_RS08270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EWA65_RS08290	COG4783	chaperone-mediated protein folding
EWA65_RS08295	COG1393	Belongs to the ArsC family
EWA65_RS08315	COG2233	PERMEase
EWA65_RS08320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EWA65_RS08325	COG0737	Belongs to the 5'-nucleotidase family
EWA65_RS08330	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EWA65_RS08335	COG2912	Transglutaminase-like superfamily
EWA65_RS08345	COG2890	protein-(glutamine-N5) methyltransferase activity
EWA65_RS08350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EWA65_RS08355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EWA65_RS08360	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EWA65_RS08370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EWA65_RS08375	COG0193	aminoacyl-tRNA hydrolase activity
EWA65_RS08380	COG0012	GTP binding
EWA65_RS08465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA65_RS08470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA65_RS08485	COG3951	Flagellar rod assembly protein muramidase FlgJ
EWA65_RS08485	COG1705	Flagellar rod assembly protein muramidase FlgJ
EWA65_RS08490	COG1706	bacterial-type flagellum-dependent cell motility
EWA65_RS08495	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EWA65_RS08505	COG4787	bacterial-type flagellum-dependent cell motility
EWA65_RS08510	COG1749	Flagellar hook protein flgE
EWA65_RS08525	COG1815	bacterial-type flagellum-dependent cell motility
EWA65_RS08530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EWA65_RS08535	COG0784	Response regulator, receiver
EWA65_RS08535	COG0835	chemotaxis
EWA65_RS08545	COG2747	anti-sigma28 factor FlgM
EWA65_RS08585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EWA65_RS08590	COG2217	Heavy metal translocating P-type atpase
EWA65_RS08590	COG2608	mercury ion transmembrane transporter activity
EWA65_RS08620	COG2840	Smr protein MutS2
EWA65_RS08625	COG1187	pseudouridine synthase activity
EWA65_RS08630	COG3706	GGDEF domain
EWA65_RS08635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EWA65_RS08640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EWA65_RS08645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EWA65_RS08650	COG0121	glutamine amidotransferase
EWA65_RS08655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EWA65_RS08660	COG1960	acyl-CoA dehydrogenase activity
EWA65_RS08665	COG3385	transposase activity
EWA65_RS08680	COG0328	RNA-DNA hybrid ribonuclease activity
EWA65_RS08685	COG2226	methyltransferase
EWA65_RS08690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWA65_RS08695	COG0741	lytic transglycosylase activity
EWA65_RS08695	COG1388	LysM domain
EWA65_RS08700	COG3021	interspecies interaction between organisms
EWA65_RS08705	COG0347	Belongs to the P(II) protein family
EWA65_RS08715	COG0037	tRNA processing
EWA65_RS08720	COG0825	malonyl-CoA metabolic process
EWA65_RS08725	COG0587	DNA-directed DNA polymerase activity
EWA65_RS08730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EWA65_RS08735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA65_RS08740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA65_RS08745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EWA65_RS08750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA65_RS08755	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EWA65_RS08765	COG0750	zinc metalloprotease
EWA65_RS08770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EWA65_RS08775	COG0575	Belongs to the CDS family
EWA65_RS08780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EWA65_RS08785	COG0233	cytoplasmic translational termination
EWA65_RS08790	COG0528	UMP kinase activity
EWA65_RS08795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EWA65_RS08800	COG0052	Belongs to the universal ribosomal protein uS2 family
EWA65_RS08805	COG0024	Methionine aminopeptidase
EWA65_RS08810	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EWA65_RS08820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EWA65_RS08825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EWA65_RS08830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EWA65_RS08835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EWA65_RS08850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EWA65_RS08850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EWA65_RS08855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EWA65_RS08860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EWA65_RS08865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EWA65_RS08875	COG1073	alpha beta
EWA65_RS08880	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EWA65_RS08885	COG2252	PERMEase
EWA65_RS08895	COG2195	Cleaves the N-terminal amino acid of tripeptides
EWA65_RS08900	COG4067	protein conserved in archaea
EWA65_RS08900	COG0189	ligase activity
EWA65_RS08905	COG0189	ligase activity
EWA65_RS08915	COG0733	neurotransmitter:sodium symporter activity
EWA65_RS08920	COG3706	GGDEF domain
EWA65_RS08920	COG4251	negative regulation of phosphorylation
EWA65_RS08920	COG5001	Diguanylate cyclase
EWA65_RS08920	COG2203	Gaf domain
EWA65_RS08930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EWA65_RS08940	COG1477	protein flavinylation
EWA65_RS08945	COG2871	sodium ion transport
EWA65_RS08950	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EWA65_RS08955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EWA65_RS08960	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EWA65_RS08965	COG1805	sodium ion transport
EWA65_RS08970	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EWA65_RS08975	COG0271	Belongs to the BolA IbaG family
EWA65_RS08980	COG2813	Specifically methylates the guanine in position
EWA65_RS08995	COG2211	Major facilitator Superfamily
EWA65_RS09005	COG1595	DNA-templated transcription, initiation
EWA65_RS09020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EWA65_RS09025	COG0693	protein deglycase activity
EWA65_RS09030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EWA65_RS09035	COG2166	iron-sulfur cluster assembly
EWA65_RS09040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EWA65_RS09045	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EWA65_RS09055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EWA65_RS09055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EWA65_RS09065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EWA65_RS09070	COG1074	ATP-dependent DNA helicase activity
EWA65_RS09075	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EWA65_RS09090	COG3141	response to X-ray
EWA65_RS09095	COG2171	N-acyltransferase activity
EWA65_RS09105	COG0456	acetyltransferase
EWA65_RS09125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWA65_RS09130	COG1609	Transcriptional regulator
EWA65_RS09135	COG3250	beta-galactosidase activity
EWA65_RS09140	COG2059	Chromate
EWA65_RS09150	COG1022	Amp-dependent synthetase and ligase
EWA65_RS09155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EWA65_RS09160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EWA65_RS09170	COG0560	Phosphoserine phosphatase
EWA65_RS09180	COG0813	purine-nucleoside phosphorylase activity
EWA65_RS09185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EWA65_RS09190	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EWA65_RS09195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EWA65_RS09205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EWA65_RS09210	COG0084	hydrolase, TatD family'
EWA65_RS09215	COG3022	response to hydroperoxide
EWA65_RS09220	COG1115	amino acid carrier protein
EWA65_RS09235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EWA65_RS09240	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EWA65_RS09245	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EWA65_RS09250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EWA65_RS09255	COG0083	homoserine kinase activity
EWA65_RS09285	COG0745	RESPONSE REGULATOR receiver
EWA65_RS09290	COG5002	protein histidine kinase activity
EWA65_RS09290	COG2198	Histidine kinase
EWA65_RS09290	COG0784	Response regulator, receiver
EWA65_RS09295	COG5001	Diguanylate cyclase
EWA65_RS09295	COG4251	negative regulation of phosphorylation
EWA65_RS09295	COG3706	GGDEF domain
EWA65_RS09295	COG2203	Gaf domain
EWA65_RS09300	COG1242	4 iron, 4 sulfur cluster binding
EWA65_RS09305	COG0070	glutamate synthase
EWA65_RS09305	COG0067	glutamate synthase
EWA65_RS09305	COG0069	glutamate synthase activity
EWA65_RS09315	COG0067	glutamate synthase
EWA65_RS09315	COG0069	glutamate synthase activity
EWA65_RS09315	COG0070	glutamate synthase
EWA65_RS09320	COG0493	'glutamate synthase
EWA65_RS09330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EWA65_RS09340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EWA65_RS09345	COG2860	membrane
EWA65_RS09350	COG0583	DNA-binding transcription factor activity
EWA65_RS09355	COG0730	response to heat
EWA65_RS09360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EWA65_RS09365	COG0505	Belongs to the CarA family
EWA65_RS09370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EWA65_RS09375	COG0494	nUDIX hydrolase
EWA65_RS09380	COG0653	protein targeting
EWA65_RS09390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EWA65_RS09395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EWA65_RS09400	COG0849	cell division
EWA65_RS09405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EWA65_RS09410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EWA65_RS09415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EWA65_RS09420	COG0772	Belongs to the SEDS family
EWA65_RS09425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EWA65_RS09435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EWA65_RS09440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EWA65_RS09445	COG0768	penicillin binding
EWA65_RS09450	COG3116	cell division
EWA65_RS09465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWA65_RS09470	COG0508	dehydrogenase complex catalyzes the overall conversion of
EWA65_RS09475	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EWA65_RS09480	COG2186	Transcriptional regulator
EWA65_RS09485	COG0737	Belongs to the 5'-nucleotidase family
EWA65_RS09490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EWA65_RS09495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EWA65_RS09500	COG4974	Belongs to the 'phage' integrase family
EWA65_RS09505	COG0716	FMN binding
EWA65_RS09515	COG0157	Belongs to the NadC ModD family
EWA65_RS09525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EWA65_RS09530	COG1459	type II secretion system
EWA65_RS09540	COG0237	dephospho-CoA kinase activity
EWA65_RS09545	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EWA65_RS09555	COG3385	transposase activity
EWA65_RS09560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EWA65_RS09565	COG0187	DNA topoisomerase II activity
EWA65_RS09570	COG3150	esterase
EWA65_RS09580	COG3151	Protein conserved in bacteria
EWA65_RS09585	COG0494	nUDIX hydrolase
EWA65_RS09590	COG1538	Outer membrane efflux protein
EWA65_RS09600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EWA65_RS09610	COG3025	triphosphatase activity
EWA65_RS09615	COG1392	Phosphate transport regulator
EWA65_RS09620	COG0306	phosphate transporter
EWA65_RS09625	COG4991	sh3 domain protein
EWA65_RS09635	COG3267	Type II secretory pathway component ExeA
EWA65_RS09635	COG3409	Peptidoglycan-binding domain 1 protein
EWA65_RS09640	COG0617	tRNA 3'-terminal CCA addition
EWA65_RS09645	COG0148	phosphopyruvate hydratase activity
EWA65_RS09650	COG0504	CTP synthase activity
EWA65_RS09655	COG3956	TIGRFAM MazG family protein
EWA65_RS09660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EWA65_RS09670	COG2205	protein histidine kinase activity
EWA65_RS09670	COG4999	Histidine kinase
EWA65_RS09670	COG3437	response regulator, receiver
EWA65_RS09670	COG3850	Histidine kinase
EWA65_RS09675	COG5001	Diguanylate cyclase
EWA65_RS09690	COG0736	holo-[acyl-carrier-protein] synthase activity
EWA65_RS09695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EWA65_RS09700	COG1381	Involved in DNA repair and RecF pathway recombination
EWA65_RS09705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EWA65_RS09710	COG0571	ribonuclease III activity
EWA65_RS09720	COG0481	GTPase activity
EWA65_RS09725	COG3086	response to oxidative stress
EWA65_RS09740	COG1595	DNA-templated transcription, initiation
EWA65_RS09745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EWA65_RS09755	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EWA65_RS09770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWA65_RS09775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWA65_RS09780	COG3079	Belongs to the UPF0149 family
EWA65_RS09785	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EWA65_RS09795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EWA65_RS09800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EWA65_RS09805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EWA65_RS09810	COG0440	acetolactate synthase activity
EWA65_RS09815	COG0028	Belongs to the TPP enzyme family
EWA65_RS09820	COG1022	Amp-dependent synthetase and ligase
EWA65_RS09825	COG0583	DNA-binding transcription factor activity
EWA65_RS09850	COG0473	3-isopropylmalate dehydrogenase activity
EWA65_RS09855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EWA65_RS09860	COG0066	3-isopropylmalate dehydratase activity
EWA65_RS09910	COG3437	response regulator, receiver
EWA65_RS09925	COG0795	lipopolysaccharide-transporting ATPase activity
EWA65_RS09930	COG0795	lipopolysaccharide-transporting ATPase activity
EWA65_RS09935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EWA65_RS09940	COG2927	DNA polymerase III (CHI subunit)
EWA65_RS09945	COG0525	valine-tRNA ligase activity
EWA65_RS09955	COG4269	membrane
EWA65_RS09960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EWA65_RS09965	COG0564	pseudouridine synthase activity
EWA65_RS09975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EWA65_RS09985	COG0540	Belongs to the ATCase OTCase family
EWA65_RS09995	COG0251	oxidation-reduction process
EWA65_RS10005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EWA65_RS10010	COG5007	Belongs to the BolA IbaG family
EWA65_RS10020	COG2854	intermembrane phospholipid transfer
EWA65_RS10025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EWA65_RS10030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EWA65_RS10035	COG1127	ABC transporter
EWA65_RS10045	COG0517	IMP dehydrogenase activity
EWA65_RS10045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EWA65_RS10060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EWA65_RS10065	COG1137	ATPase activity
EWA65_RS10075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EWA65_RS10080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA65_RS10085	COG1660	Displays ATPase and GTPase activities
EWA65_RS10090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA65_RS10095	COG2239	Acts as a magnesium transporter
EWA65_RS10100	COG0312	modulator of DNA gyrase
EWA65_RS10105	COG3028	Belongs to the UPF0307 family
EWA65_RS10110	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EWA65_RS10115	COG1178	ABC-type Fe3 transport system permease component
EWA65_RS10125	COG0163	prenyltransferase activity
EWA65_RS10130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EWA65_RS10135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EWA65_RS10140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EWA65_RS10150	COG2105	PFAM AIG2 family protein
EWA65_RS10160	COG0729	surface antigen
EWA65_RS10165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWA65_RS10170	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EWA65_RS10185	COG1136	(ABC) transporter
EWA65_RS10185	COG0577	efflux transmembrane transporter activity
EWA65_RS10205	COG0529	Catalyzes the synthesis of activated sulfate
EWA65_RS10210	COG2895	sulfate adenylyltransferase (ATP) activity
EWA65_RS10215	COG0175	sulfate reduction
EWA65_RS10220	COG1648	precorrin-2 dehydrogenase activity
EWA65_RS10220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EWA65_RS10225	COG0737	Belongs to the 5'-nucleotidase family
EWA65_RS10235	COG0513	Belongs to the DEAD box helicase family
EWA65_RS10240	COG2153	protein acetylation
EWA65_RS10245	COG0697	spore germination
EWA65_RS10250	COG3061	Opacity-associated protein A
EWA65_RS10250	COG3266	domain, Protein
EWA65_RS10255	COG0545	Peptidyl-prolyl cis-trans isomerase
EWA65_RS10265	COG0203	ribosomal protein L17
EWA65_RS10270	COG0202	RNA polymerase activity
EWA65_RS10275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EWA65_RS10280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EWA65_RS10285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EWA65_RS10290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EWA65_RS10295	COG0201	protein transport
EWA65_RS10305	COG1841	ribosomal large subunit assembly
EWA65_RS10310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EWA65_RS10315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EWA65_RS10325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EWA65_RS10330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EWA65_RS10335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EWA65_RS10340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EWA65_RS10345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EWA65_RS10350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EWA65_RS10355	COG0255	Belongs to the universal ribosomal protein uL29 family
EWA65_RS10360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EWA65_RS10365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EWA65_RS10370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EWA65_RS10375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EWA65_RS10380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EWA65_RS10385	COG0089	rRNA binding
EWA65_RS10390	COG0088	Forms part of the polypeptide exit tunnel
EWA65_RS10395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EWA65_RS10400	COG0051	transcription antitermination factor activity, RNA binding
EWA65_RS10405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EWA65_RS10410	COG0557	exoribonuclease II activity
EWA65_RS10415	COG3083	sulfuric ester hydrolase activity
EWA65_RS10420	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EWA65_RS10430	COG1446	asparaginase
EWA65_RS10435	COG1047	Peptidyl-prolyl cis-trans
EWA65_RS10450	COG2249	NAD(P)H dehydrogenase (quinone) activity
EWA65_RS10455	COG0488	(ABC) transporter
EWA65_RS10465	COG0429	hydrolase of the alpha beta-hydrolase fold
EWA65_RS10475	COG3954	Phosphoribulokinase
EWA65_RS10490	COG1012	belongs to the aldehyde dehydrogenase family
EWA65_RS10500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EWA65_RS10510	COG0446	pyridine nucleotide-disulphide oxidoreductase
EWA65_RS10515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EWA65_RS10530	COG0180	Tryptophanyl-tRNA synthetase
EWA65_RS10535	COG0546	phosphoglycolate phosphatase activity
EWA65_RS10540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EWA65_RS10545	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EWA65_RS10555	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EWA65_RS10560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EWA65_RS10590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EWA65_RS10600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EWA65_RS10600	COG0678	peroxiredoxin activity
EWA65_RS10605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWA65_RS10615	COG0165	Argininosuccinate lyase
EWA65_RS10620	COG0137	argininosuccinate synthase activity
EWA65_RS10625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EWA65_RS10630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EWA65_RS10635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EWA65_RS10640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EWA65_RS10650	COG1045	serine acetyltransferase
EWA65_RS10655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EWA65_RS10660	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EWA65_RS10665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EWA65_RS10670	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EWA65_RS10675	COG1053	succinate dehydrogenase
EWA65_RS10680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EWA65_RS10685	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EWA65_RS10695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EWA65_RS10700	COG1509	lysine 2,3-aminomutase activity
EWA65_RS10710	COG0459	protein refolding
EWA65_RS10715	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EWA65_RS10740	COG0149	triose-phosphate isomerase activity
EWA65_RS10745	COG0534	Mate efflux family protein
EWA65_RS10750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EWA65_RS10755	COG1575	Belongs to the MenA family. Type 1 subfamily
EWA65_RS10760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EWA65_RS10765	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EWA65_RS10770	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EWA65_RS10775	COG1609	Transcriptional regulator
EWA65_RS10780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EWA65_RS10785	COG0254	rRNA binding
EWA65_RS10790	COG0281	malic enzyme
EWA65_RS10795	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EWA65_RS10800	COG0626	cystathionine gamma-synthase activity
EWA65_RS10805	COG0460	homoserine dehydrogenase
EWA65_RS10805	COG0527	aspartate kinase activity
EWA65_RS10810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EWA65_RS10815	COG3074	FtsZ-dependent cytokinesis
EWA65_RS10820	COG1494	fructose-1,6-bisphosphatase
EWA65_RS10825	COG0205	6-phosphofructokinase activity
EWA65_RS10840	COG0745	RESPONSE REGULATOR receiver
EWA65_RS10845	COG2205	protein histidine kinase activity
EWA65_RS10850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EWA65_RS10855	COG3030	protein affecting phage T7 exclusion by the F plasmid
EWA65_RS10865	COG1027	Aspartate ammonia-lyase
EWA65_RS10870	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EWA65_RS10875	COG4232	protein-disulfide reductase activity
EWA65_RS10895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWA65_RS10900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EWA65_RS10905	COG0194	GDP metabolic process
EWA65_RS10910	COG1758	RNA polymerase activity
EWA65_RS10915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EWA65_RS10920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EWA65_RS10925	COG2233	PERMEase
EWA65_RS10940	COG2199	diguanylate cyclase activity
EWA65_RS10945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EWA65_RS10950	COG2183	response to ionizing radiation
EWA65_RS10960	COG0596	Alpha beta hydrolase
EWA65_RS10965	COG1040	competence protein
EWA65_RS10975	COG0494	nUDIX hydrolase
EWA65_RS10980	COG1218	3'(2'),5'-bisphosphate nucleotidase
EWA65_RS10990	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EWA65_RS10995	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EWA65_RS11000	COG3156	type II secretion system protein K
EWA65_RS11005	COG4795	General secretion pathway protein
EWA65_RS11010	COG2165	general secretion pathway protein
EWA65_RS11015	COG2165	general secretion pathway protein
EWA65_RS11020	COG2165	general secretion pathway protein
EWA65_RS11025	COG1459	type II secretion system
EWA65_RS11030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EWA65_RS11040	COG3031	protein transport across the cell outer membrane
EWA65_RS11045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EWA65_RS11050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EWA65_RS11055	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EWA65_RS11065	COG0456	acetyltransferase
EWA65_RS11070	COG1490	D-aminoacyl-tRNA deacylase activity
EWA65_RS11075	COG1295	ribonuclease BN
EWA65_RS11080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EWA65_RS11085	COG1217	gtp-binding protein TYPA
EWA65_RS11090	COG0174	glutamine synthetase
EWA65_RS11100	COG3852	Histidine kinase
EWA65_RS11110	COG5001	Diguanylate cyclase
EWA65_RS11110	COG3300	MHYT domain
EWA65_RS11115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EWA65_RS11185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EWA65_RS11200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EWA65_RS11215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWA65_RS11220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EWA65_RS11225	COG2177	Part of the ABC transporter FtsEX involved in
EWA65_RS11230	COG2884	Cell division ATP-binding protein ftsE
EWA65_RS11235	COG0552	protein localization to endoplasmic reticulum
EWA65_RS11240	COG0742	ribosomal rna small subunit methyltransferase
EWA65_RS11275	COG0783	Belongs to the Dps family
EWA65_RS11280	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EWA65_RS11285	COG1280	lysine exporter protein (LysE YggA)
EWA65_RS11290	COG2267	carboxylic ester hydrolase activity
EWA65_RS11295	COG0561	phosphatase activity
EWA65_RS11310	COG2199	diguanylate cyclase activity
EWA65_RS11310	COG3287	FIST C domain
EWA65_RS11310	COG2200	EAL domain
EWA65_RS11315	COG1011	Hydrolase
EWA65_RS11320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EWA65_RS11330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EWA65_RS11335	COG0019	diaminopimelate decarboxylase activity
EWA65_RS11345	COG1965	Belongs to the frataxin family
EWA65_RS11350	COG3072	Adenylate cyclase
EWA65_RS11355	COG0181	hydroxymethylbilane synthase activity
EWA65_RS11360	COG1587	Uroporphyrinogen-III synthase
EWA65_RS11365	COG2959	enzyme of heme biosynthesis
EWA65_RS11370	COG3071	HemY protein
EWA65_RS11385	COG3078	GTPase activator activity
EWA65_RS11405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWA65_RS11405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWA65_RS11420	COG0084	hydrolase, TatD family'
EWA65_RS11425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EWA65_RS11435	COG1580	Controls the rotational direction of flagella during chemotaxis
EWA65_RS11445	COG3161	chorismate lyase activity
EWA65_RS11450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EWA65_RS11455	COG2937	Belongs to the GPAT DAPAT family
EWA65_RS11460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EWA65_RS11470	COG0534	Mate efflux family protein
EWA65_RS11475	COG1858	cytochrome C peroxidase
EWA65_RS11480	COG0805	protein transport
EWA65_RS11485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EWA65_RS11490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EWA65_RS11505	COG2226	methyltransferase
EWA65_RS11510	COG1322	Protein conserved in bacteria
EWA65_RS11520	COG0840	transmembrane signaling receptor activity
EWA65_RS11525	COG2081	HI0933 family
EWA65_RS11535	COG1528	Iron-storage protein
EWA65_RS11545	COG0589	response to stress
EWA65_RS11565	COG5001	Diguanylate cyclase
EWA65_RS11565	COG5002	protein histidine kinase activity
EWA65_RS11570	COG1522	sequence-specific DNA binding
EWA65_RS11590	COG0006	proline dipeptidase activity
EWA65_RS11590	COG0006	proline dipeptidase activity
EWA65_RS11595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EWA65_RS11600	COG2022	thiamine diphosphate biosynthetic process
EWA65_RS11605	COG2104	thiamine diphosphate biosynthetic process
EWA65_RS11610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EWA65_RS11620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EWA65_RS11625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EWA65_RS11665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EWA65_RS11675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EWA65_RS11685	COG0009	L-threonylcarbamoyladenylate synthase
EWA65_RS11690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EWA65_RS11695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EWA65_RS11700	COG0551	DNA topoisomerase type I activity
EWA65_RS11705	COG2922	Belongs to the Smg family
EWA65_RS11715	COG1652	LysM domain
EWA65_RS11720	COG0242	peptide deformylase activity
EWA65_RS11730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EWA65_RS11730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EWA65_RS11735	COG0569	domain protein
EWA65_RS11740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EWA65_RS11750	COG1272	protein, Hemolysin III
EWA65_RS11755	COG4326	sporulation control protein
EWA65_RS11765	COG3084	Protein conserved in bacteria
EWA65_RS11775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EWA65_RS11780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EWA65_RS11785	COG0204	Acyl-transferase
EWA65_RS11790	COG0606	chelatase, subunit chli
EWA65_RS11805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EWA65_RS11810	COG0129	dihydroxy-acid dehydratase activity
EWA65_RS11820	COG0604	alcohol dehydrogenase
EWA65_RS11835	COG0425	Belongs to the sulfur carrier protein TusA family
EWA65_RS11845	COG2119	membrane
EWA65_RS11850	COG0752	glycyl-tRNA synthetase alpha subunit
EWA65_RS11855	COG0751	glycine-tRNA ligase activity
EWA65_RS11860	COG3977	Valine--pyruvate aminotransferase
EWA65_RS11865	COG0071	Belongs to the small heat shock protein (HSP20) family
EWA65_RS11880	COG0187	DNA topoisomerase II activity
EWA65_RS11885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EWA65_RS11890	COG0592	DNA-directed DNA polymerase activity
EWA65_RS11895	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EWA65_RS11910	COG1126	abc transporter atp-binding protein
EWA65_RS11915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EWA65_RS11920	COG0594	ribonuclease P activity
EWA65_RS11930	COG0706	membrane insertase activity
EWA65_RS11935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EWA65_RS11940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EWA65_RS11945	COG0445	tRNA wobble uridine modification
EWA65_RS11950	COG0357	Ribosomal RNA small subunit methyltransferase G
EWA65_RS11955	COG1192	Involved in chromosome partitioning
EWA65_RS11960	COG1475	DNA binding
EWA65_RS11965	COG3312	ion transport
EWA65_RS11970	COG0356	it plays a direct role in the translocation of protons across the membrane
EWA65_RS11980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EWA65_RS11985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EWA65_RS11990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EWA65_RS11995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EWA65_RS12000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EWA65_RS12005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EWA65_RS12015	COG2814	Major facilitator Superfamily
EWA65_RS12020	COG0583	DNA-binding transcription factor activity
EWA65_RS12025	COG0183	Belongs to the thiolase family
EWA65_RS12030	COG1024	Enoyl-CoA hydratase
EWA65_RS12030	COG1250	3-hydroxyacyl-CoA dehydrogenase
EWA65_RS12035	COG1739	Uncharacterized protein family UPF0029
EWA65_RS12040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EWA65_RS12045	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EWA65_RS12115	COG0583	DNA-binding transcription factor activity
EWA65_RS12120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EWA65_RS12125	COG2960	long-chain fatty acid transporting porin activity
EWA65_RS12130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWA65_RS12135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWA65_RS12140	COG1309	transcriptional regulator
EWA65_RS12195	COG0747	negative chemotaxis
EWA65_RS12200	COG0601	transmembrane transport
EWA65_RS12205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA65_RS12215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWA65_RS12220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EWA65_RS12230	COG0210	DNA helicase
EWA65_RS12235	COG1280	lysine exporter protein (LysE YggA)
EWA65_RS12250	COG2962	Rard protein
EWA65_RS12255	COG0514	ATP-dependent DNA helicase (RecQ)
EWA65_RS12270	COG1132	(ABC) transporter
EWA65_RS12275	COG4774	siderophore transport
EWA65_RS12280	COG1120	ATPase activity
EWA65_RS12305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EWA65_RS12310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA65_RS12310	COG1263	PTS System
EWA65_RS12315	COG2862	Uncharacterized protein family, UPF0114
EWA65_RS12320	COG1561	YicC-like family, N-terminal region
EWA65_RS12325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EWA65_RS12330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EWA65_RS12335	COG3385	transposase activity
EWA65_RS12340	COG1560	Kdo2-lipid A biosynthetic process
EWA65_RS12345	COG1560	Kdo2-lipid A biosynthetic process
EWA65_RS12350	COG1309	transcriptional regulator
EWA65_RS12355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EWA65_RS12365	COG2003	Belongs to the UPF0758 family
EWA65_RS12370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EWA65_RS12375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EWA65_RS12385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EWA65_RS12390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EWA65_RS12395	COG0859	PFAM glycosyl transferase family 9
EWA65_RS12400	COG0463	Glycosyl transferase, family 2
EWA65_RS12405	COG0859	PFAM glycosyl transferase family 9
EWA65_RS12410	COG3642	lipopolysaccharide core region biosynthetic process
EWA65_RS12435	COG1519	Transferase
EWA65_RS12470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWA65_RS12480	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWA65_RS12510	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
EWA65_RS12515	COG5433	transposase activity
EWA65_RS12520	COG1086	Polysaccharide biosynthesis protein
EWA65_RS12525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EWA65_RS12530	COG1083	cytidylyl-transferase
EWA65_RS12540	COG2089	acid synthase
EWA65_RS12550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EWA65_RS12590	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EWA65_RS12595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWA65_RS12600	COG1051	belongs to the nudix hydrolase family
EWA65_RS12630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EWA65_RS12665	COG0668	transmembrane transport
EWA65_RS12670	COG1573	uracil-dna glycosylase
EWA65_RS12680	COG3068	Protein conserved in bacteria
EWA65_RS12685	COG1253	flavin adenine dinucleotide binding
EWA65_RS12690	COG0776	regulation of translation
EWA65_RS12700	COG0151	Belongs to the GarS family
EWA65_RS12715	COG0789	Transcriptional regulator
EWA65_RS12720	COG3710	Transcriptional regulator
EWA65_RS12725	COG0531	amino acid
EWA65_RS12730	COG1982	Orn Lys Arg decarboxylase major
EWA65_RS12735	COG3385	transposase activity
EWA65_RS12740	COG0840	transmembrane signaling receptor activity
EWA65_RS12745	COG0800	Aldolase
EWA65_RS12750	COG2610	gluconate transmembrane transporter activity
EWA65_RS12755	COG3265	gluconokinase activity
EWA65_RS12760	COG0129	dihydroxy-acid dehydratase activity
EWA65_RS12765	COG1609	Transcriptional regulator
EWA65_RS12770	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EWA65_RS12775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EWA65_RS12785	COG0439	Biotin carboxylase
EWA65_RS12790	COG0511	ligase activity, forming carbon-carbon bonds
EWA65_RS12795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EWA65_RS12800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EWA65_RS12815	COG2814	Major facilitator Superfamily
EWA65_RS12820	COG2205	protein histidine kinase activity
EWA65_RS12820	COG0784	Response regulator, receiver
EWA65_RS12825	COG0248	Ppx GppA phosphatase
EWA65_RS12830	COG0513	Belongs to the DEAD box helicase family
EWA65_RS12835	COG3118	belongs to the thioredoxin family
EWA65_RS12850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EWA65_RS12895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EWA65_RS12905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EWA65_RS12915	COG1072	(Pantothenic acid kinase))
EWA65_RS12940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EWA65_RS12945	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EWA65_RS12950	COG0250	Participates in transcription elongation, termination and antitermination
EWA65_RS12955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EWA65_RS12965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EWA65_RS12970	COG0222	ribosome binding
EWA65_RS12975	COG0085	RNA polymerase activity
EWA65_RS12980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EWA65_RS12985	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EWA65_RS12990	COG2816	NAD+ diphosphatase activity
EWA65_RS12995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EWA65_RS13010	COG4942	peptidase
EWA65_RS13015	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EWA65_RS13030	COG0688	phosphatidylethanolamine metabolic process
EWA65_RS13035	COG1162	GTPase activity
EWA65_RS13040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EWA65_RS13090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EWA65_RS13095	COG0802	atpase or kinase
EWA65_RS13105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EWA65_RS13110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EWA65_RS13115	COG1923	regulation of RNA biosynthetic process
EWA65_RS13120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EWA65_RS13125	COG0330	HflC and HflK could
EWA65_RS13130	COG0330	HflC and HflK could
EWA65_RS13135	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EWA65_RS13140	COG2900	Belongs to the SlyX family
EWA65_RS13150	COG0545	Peptidyl-prolyl cis-trans isomerase
EWA65_RS13155	COG2964	Protein conserved in bacteria
EWA65_RS13160	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EWA65_RS13165	COG2923	Belongs to the DsrF TusC family
EWA65_RS13210	COG3829	transcription factor binding
EWA65_RS13250	COG1869	D-ribose catabolic process
EWA65_RS13255	COG1129	ABC transporter
EWA65_RS13260	COG1172	Belongs to the binding-protein-dependent transport system permease family
EWA65_RS13265	COG1879	ABC-type sugar transport system periplasmic component
EWA65_RS13270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA65_RS13275	COG1609	Transcriptional regulator
EWA65_RS13280	COG3447	MASE1 domain protein
EWA65_RS13280	COG5001	Diguanylate cyclase
EWA65_RS13280	COG5002	protein histidine kinase activity
EWA65_RS13290	COG0584	glycerophosphoryl diester phosphodiesterase
EWA65_RS13295	COG2271	Major facilitator Superfamily
EWA65_RS13335	COG0579	oxidoreductase
EWA65_RS13355	COG0488	(ABC) transporter
EWA65_RS13360	COG0814	amino acid
EWA65_RS13375	COG3530	Putative quorum-sensing-regulated virulence factor
EWA65_RS13390	COG1278	Cold shock
EWA65_RS13405	COG2304	oxidoreductase activity
EWA65_RS13425	COG0714	Associated with various cellular activities
EWA65_RS13430	COG0840	transmembrane signaling receptor activity
EWA65_RS13450	COG2195	Cleaves the N-terminal amino acid of tripeptides
EWA65_RS13460	COG3604	Transcriptional regulator
EWA65_RS13465	COG1017	nitric oxide dioxygenase activity
EWA65_RS13465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EWA65_RS13470	COG1278	Cold shock
EWA65_RS13500	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EWA65_RS13500	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EWA65_RS13505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EWA65_RS13515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EWA65_RS13525	COG3385	transposase activity
EWA65_RS13530	COG0516	GMP reductase activity
EWA65_RS13535	COG0513	Belongs to the DEAD box helicase family
EWA65_RS13540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EWA65_RS13545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EWA65_RS13550	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EWA65_RS13555	COG0840	transmembrane signaling receptor activity
EWA65_RS13560	COG0784	Response regulator, receiver
EWA65_RS13560	COG3437	response regulator, receiver
EWA65_RS13565	COG4191	Histidine kinase
EWA65_RS13565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA65_RS13575	COG1757	Na H antiporter
EWA65_RS13580	COG2814	Major facilitator Superfamily
EWA65_RS13590	COG3706	GGDEF domain
EWA65_RS13595	COG3240	lipase activity
EWA65_RS13605	COG0840	transmembrane signaling receptor activity
EWA65_RS13610	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EWA65_RS13615	COG5380	lipid catabolic process
EWA65_RS13640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWA65_RS13645	COG4605	iron ion homeostasis
EWA65_RS13650	COG4604	ABC transporter, ATP-binding protein
EWA65_RS13670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EWA65_RS13675	COG3385	transposase activity
EWA65_RS13705	COG3623	hexulose-6-phosphate isomerase
EWA65_RS13710	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EWA65_RS13715	COG0561	phosphatase activity
EWA65_RS13765	COG0745	RESPONSE REGULATOR receiver
EWA65_RS13785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EWA65_RS13795	COG3397	chitin binding
EWA65_RS13800	COG3046	protein related to deoxyribodipyrimidine photolyase
EWA65_RS13810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EWA65_RS13825	COG0513	Belongs to the DEAD box helicase family
EWA65_RS13835	COG1368	sulfuric ester hydrolase activity
EWA65_RS13840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA65_RS13870	COG0484	heat shock protein binding
EWA65_RS13880	COG5001	Diguanylate cyclase
EWA65_RS13880	COG1716	ATPase activity
EWA65_RS13885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EWA65_RS13895	COG4181	ATPase activity
EWA65_RS13900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EWA65_RS13915	COG1984	allophanate hydrolase subunit 2
EWA65_RS13920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EWA65_RS13925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EWA65_RS13930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EWA65_RS13935	COG0840	transmembrane signaling receptor activity
EWA65_RS13940	COG0814	amino acid
EWA65_RS13945	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EWA65_RS13950	COG0513	Belongs to the DEAD box helicase family
EWA65_RS13955	COG1309	transcriptional regulator
EWA65_RS13965	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EWA65_RS13970	COG0494	nUDIX hydrolase
EWA65_RS13980	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EWA65_RS13990	COG1126	abc transporter atp-binding protein
EWA65_RS13995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA65_RS14000	COG4215	(ABC) transporter
EWA65_RS14005	COG4160	amino acid transport
EWA65_RS14010	COG0583	DNA-binding transcription factor activity
EWA65_RS14040	COG3118	belongs to the thioredoxin family
EWA65_RS14045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EWA65_RS14050	COG0247	lactate metabolic process
EWA65_RS14055	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EWA65_RS14060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EWA65_RS14065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EWA65_RS14080	COG2926	Belongs to the UPF0265 family
EWA65_RS14090	COG3132	Protein of unknown function, DUF480
EWA65_RS14095	COG2827	Endonuclease containing a URI domain
EWA65_RS14105	COG1879	ABC-type sugar transport system periplasmic component
EWA65_RS14110	COG5002	protein histidine kinase activity
EWA65_RS14110	COG0784	Response regulator, receiver
EWA65_RS14135	COG0725	ABC transporter, periplasmic molybdate-binding protein
EWA65_RS14140	COG4149	molybdate abc transporter
EWA65_RS14145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EWA65_RS14175	COG1289	transmembrane transporter activity
EWA65_RS14180	COG0210	DNA helicase
EWA65_RS14195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EWA65_RS14205	COG1335	isochorismatase
EWA65_RS14210	COG1803	Methylglyoxal synthase
EWA65_RS14215	COG1879	ABC-type sugar transport system periplasmic component
EWA65_RS14220	COG2198	Histidine kinase
EWA65_RS14220	COG2205	protein histidine kinase activity
EWA65_RS14220	COG0784	Response regulator, receiver
EWA65_RS14225	COG0469	pyruvate kinase activity
EWA65_RS14230	COG2271	Major facilitator Superfamily
EWA65_RS14240	COG4191	Histidine kinase
EWA65_RS14265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EWA65_RS14285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWA65_RS14290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWA65_RS14300	COG0183	Belongs to the thiolase family
EWA65_RS14310	COG3243	poly(R)-hydroxyalkanoic acid synthase
EWA65_RS14315	COG3842	ATPase activity
EWA65_RS14325	COG1840	ABC-type Fe3 transport system, periplasmic component
EWA65_RS14330	COG2271	Major facilitator Superfamily
EWA65_RS14335	COG3851	Histidine kinase
EWA65_RS14340	COG2197	response regulator
EWA65_RS14345	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EWA65_RS14355	COG3005	denitrification pathway
EWA65_RS14365	COG0243	molybdopterin cofactor binding
EWA65_RS14375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EWA65_RS14380	COG3850	Histidine kinase
EWA65_RS14385	COG2197	response regulator
EWA65_RS14390	COG1760	l-serine dehydratase
EWA65_RS14395	COG3069	C4-dicarboxylate transmembrane transporter activity
EWA65_RS14405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EWA65_RS14410	COG0545	Peptidyl-prolyl cis-trans isomerase
EWA65_RS14425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA65_RS14430	COG1621	beta-fructofuranosidase activity
EWA65_RS14435	COG1609	Transcriptional regulator
EWA65_RS14440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA65_RS14440	COG1263	PTS System
EWA65_RS14495	COG0640	Transcriptional regulator
EWA65_RS14505	COG2391	methyltransferase activity
EWA65_RS14525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EWA65_RS14530	COG0583	DNA-binding transcription factor activity
EWA65_RS14555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EWA65_RS14570	COG1073	alpha beta
EWA65_RS14585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EWA65_RS14600	COG2390	Transcriptional regulator
EWA65_RS14610	COG2897	thiosulfate sulfurtransferase activity
EWA65_RS14620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EWA65_RS14630	COG0302	gtp cyclohydrolase
EWA65_RS14635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWA65_RS14635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWA65_RS14640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EWA65_RS14645	COG1970	mechanosensitive ion channel activity
EWA65_RS14650	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EWA65_RS14660	COG1011	Hydrolase
EWA65_RS14665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EWA65_RS14670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EWA65_RS14675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EWA65_RS14680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EWA65_RS14690	COG3842	ATPase activity
EWA65_RS14710	COG3104	oligopeptide transport
EWA65_RS14735	COG4166	transmembrane transport
EWA65_RS14740	COG4174	ABC transporter (Permease)
EWA65_RS14745	COG4239	(ABC) transporter, permease
EWA65_RS14750	COG4172	Belongs to the ABC transporter superfamily
EWA65_RS14755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EWA65_RS14770	COG0625	glutathione transferase activity
EWA65_RS14785	COG0501	Belongs to the peptidase M48B family
EWA65_RS14790	COG2050	protein possibly involved in aromatic compounds catabolism
EWA65_RS14810	COG4771	TonB-dependent receptor
EWA65_RS14810	COG1629	transport
EWA65_RS14815	COG0583	DNA-binding transcription factor activity
EWA65_RS14820	COG0045	succinate-CoA ligase (ADP-forming) activity
EWA65_RS14820	COG1042	CoA-binding domain protein
EWA65_RS14820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA65_RS14840	COG0023	Translation Initiation Factor
EWA65_RS14860	COG3140	Belongs to the UPF0181 family
EWA65_RS14885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EWA65_RS14890	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EWA65_RS14905	COG3706	GGDEF domain
EWA65_RS14925	COG3706	GGDEF domain
EWA65_RS14960	COG2824	Alkylphosphonate utilization operon protein PhnA
EWA65_RS14970	COG0861	Integral membrane protein TerC family
EWA65_RS14975	COG0737	Belongs to the 5'-nucleotidase family
EWA65_RS14980	COG3593	DNA synthesis involved in DNA repair
EWA65_RS14990	COG0583	DNA-binding transcription factor activity
EWA65_RS14995	COG2116	formate transmembrane transporter activity
EWA65_RS15005	COG3038	cytochrome b561
EWA65_RS15015	COG2200	EAL domain
EWA65_RS15030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EWA65_RS15035	COG0745	RESPONSE REGULATOR receiver
EWA65_RS15040	COG2205	protein histidine kinase activity
EWA65_RS15045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EWA65_RS15045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EWA65_RS15045	COG1013	pyruvate-flavodoxin oxidoreductase activity
EWA65_RS15045	COG0674	pyruvate-flavodoxin oxidoreductase activity
EWA65_RS15050	COG3158	transport of potassium into the cell
EWA65_RS15060	COG0523	cobalamin synthesis protein
EWA65_RS15065	COG0038	chloride channel
EWA65_RS15075	COG0156	8-amino-7-oxononanoate synthase activity
EWA65_RS15080	COG2205	protein histidine kinase activity
EWA65_RS15080	COG0784	Response regulator, receiver
EWA65_RS15085	COG0419	ATPase involved in DNA repair
EWA65_RS15090	COG0420	3'-5' exonuclease activity
EWA65_RS15095	COG1609	Transcriptional regulator
EWA65_RS15100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA65_RS15100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA65_RS15105	COG1105	Belongs to the carbohydrate kinase PfkB family
EWA65_RS15110	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EWA65_RS15110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS15110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA65_RS15115	COG0189	ligase activity
EWA65_RS15115	COG4067	protein conserved in archaea
EWA65_RS15125	COG0602	queuosine metabolic process
EWA65_RS15130	COG1328	CTP reductase activity
EWA65_RS15215	COG0110	maltose O-acetyltransferase activity
EWA65_RS15220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EWA65_RS15375	COG4977	sequence-specific DNA binding
EWA65_RS15380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EWA65_RS15435	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EWA65_RS15655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA65_RS15665	COG0346	lactoylglutathione lyase activity
EWA65_RS15680	COG0494	nUDIX hydrolase
EWA65_RS15775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA65_RS15845	COG0222	ribosome binding
EWA65_RS15900	COG0384	phenazine biosynthesis protein PhzF
EWA65_RS16025	COG0494	nUDIX hydrolase
EWA65_RS16045	COG0346	lactoylglutathione lyase activity
EWA65_RS16075	COG0456	acetyltransferase
EWA65_RS16130	COG0346	lactoylglutathione lyase activity
EWA65_RS16150	COG2944	sequence-specific DNA binding
EWA65_RS16155	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EWA65_RS16240	COG3040	lipid binding
EWA65_RS16390	COG0494	nUDIX hydrolase
EWA65_RS16415	COG0384	phenazine biosynthesis protein PhzF
EWA65_RS16425	COG2176	DNA-directed DNA polymerase activity
EWA65_RS16495	COG0653	protein targeting
EWA65_RS16540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA65_RS16640	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EWA65_RS16645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EWA65_RS16660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EWA65_RS16670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EWA65_RS16675	COG0509	glycine decarboxylation via glycine cleavage system
EWA65_RS16685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EWA65_RS16685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EWA65_RS16690	COG3338	carbonate dehydratase activity
EWA65_RS16705	COG1686	Belongs to the peptidase S11 family
EWA65_RS16720	COG1414	Transcriptional regulator
EWA65_RS16730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA65_RS16735	COG0601	transmembrane transport
EWA65_RS16750	COG0641	radical SAM
EWA65_RS16755	COG3119	arylsulfatase activity
EWA65_RS16760	COG2199	diguanylate cyclase activity
EWA65_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
EWA65_RS16785	COG1085	galactose-1-phosphate uridylyltransferase
EWA65_RS16790	COG0800	Aldolase
EWA65_RS16795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA65_RS16810	COG0010	Belongs to the arginase family
EWA65_RS16815	COG1166	arginine decarboxylase activity
EWA65_RS16840	COG2239	Acts as a magnesium transporter
EWA65_RS16845	COG0527	aspartate kinase activity
EWA65_RS16850	COG0662	Cupin 2, conserved barrel domain protein
EWA65_RS16855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EWA65_RS16860	COG0456	acetyltransferase
EWA65_RS16875	COG0534	Mate efflux family protein
EWA65_RS16880	COG2154	pterin-4-alpha-carbinolamine dehydratase
EWA65_RS16885	COG3186	Phenylalanine-4-hydroxylase
EWA65_RS16890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EWA65_RS16905	COG2264	protein methyltransferase activity
EWA65_RS16930	COG1253	flavin adenine dinucleotide binding
EWA65_RS16935	COG1765	OsmC-like protein
EWA65_RS16960	COG0531	amino acid
EWA65_RS16975	COG3279	Response regulator of the LytR AlgR family
EWA65_RS16980	COG3275	phosphorelay sensor kinase activity
EWA65_RS17000	COG1136	(ABC) transporter
EWA65_RS17010	COG4989	oxidoreductase activity
EWA65_RS17015	COG0366	Alpha amylase catalytic
EWA65_RS17020	COG2067	long-chain fatty acid transport protein
EWA65_RS17025	COG2267	carboxylic ester hydrolase activity
EWA65_RS17030	COG3227	Zinc metalloprotease (Elastase)
EWA65_RS17035	COG3047	cAMP biosynthetic process
EWA65_RS17045	COG1686	Belongs to the peptidase S11 family
EWA65_RS17075	COG1063	alcohol dehydrogenase
EWA65_RS17085	COG2873	o-acetylhomoserine
EWA65_RS17095	COG0346	lactoylglutathione lyase activity
EWA65_RS17115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EWA65_RS17120	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EWA65_RS17125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EWA65_RS17130	COG0363	glucosamine-6-phosphate deaminase activity
EWA65_RS17135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EWA65_RS17165	COG1929	Belongs to the glycerate kinase type-1 family
EWA65_RS17180	COG0748	coenzyme F420 binding
EWA65_RS17185	COG3721	Heme iron utilization protein
EWA65_RS17195	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EWA65_RS17200	COG0811	peptide transport
EWA65_RS17205	COG0848	biopolymer transport protein
EWA65_RS17215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWA65_RS17220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EWA65_RS17255	COG0633	Ferredoxin
EWA65_RS17255	COG3217	Mosc domain protein beta barrel domain protein
EWA65_RS17255	COG0633	Ferredoxin
EWA65_RS17255	COG3217	Mosc domain protein beta barrel domain protein
EWA65_RS17260	COG0418	dihydroorotase activity
EWA65_RS17270	COG3152	Membrane
EWA65_RS17280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EWA65_RS17285	COG2354	Protein conserved in bacteria
EWA65_RS17290	COG0488	(ABC) transporter
EWA65_RS17300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EWA65_RS17305	COG1278	Cold shock
EWA65_RS17325	COG2199	diguanylate cyclase activity
EWA65_RS17330	COG1349	DNA-binding transcription factor activity
EWA65_RS17345	COG3833	ABC-type maltose transport systems, permease component
EWA65_RS17350	COG1175	transmembrane transport
EWA65_RS17360	COG3842	ATPase activity
EWA65_RS17440	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EWA65_RS17465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EWA65_RS17470	COG0835	chemotaxis
EWA65_RS17470	COG0784	Response regulator, receiver
EWA65_RS17475	COG1846	Transcriptional regulator
EWA65_RS17495	COG3706	GGDEF domain
EWA65_RS17515	COG0583	DNA-binding transcription factor activity
EWA65_RS17520	COG5001	Diguanylate cyclase
EWA65_RS17530	COG1741	Belongs to the pirin family
EWA65_RS17535	COG3123	guanosine phosphorylase activity
EWA65_RS17545	COG2211	Major facilitator Superfamily
EWA65_RS17555	COG1067	ATP-dependent peptidase activity
EWA65_RS17580	COG0583	DNA-binding transcription factor activity
EWA65_RS17585	COG1620	l-lactate permease
EWA65_RS17600	COG0840	transmembrane signaling receptor activity
EWA65_RS17605	COG0840	transmembrane signaling receptor activity
EWA65_RS17615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EWA65_RS17620	COG1126	abc transporter atp-binding protein
EWA65_RS17630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA65_RS17635	COG4597	amino acid ABC transporter
EWA65_RS17640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EWA65_RS17650	COG0739	heme binding
EWA65_RS17655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA65_RS17655	COG2213	PTS system mannitol-specific
EWA65_RS17660	COG0246	Mannitol dehydrogenase
EWA65_RS17665	COG3722	fumarate hydratase activity
EWA65_RS17670	COG0673	inositol 2-dehydrogenase activity
EWA65_RS17695	COG0697	spore germination
EWA65_RS17710	COG1335	isochorismatase
EWA65_RS17720	COG2910	NAD(P)H-binding
EWA65_RS17735	COG4221	oxidoreductase activity
EWA65_RS17745	COG1901	pseudouridine methyltransferase
EWA65_RS17760	COG0531	amino acid
EWA65_RS17765	COG1982	Orn Lys Arg decarboxylase major
EWA65_RS17775	COG2197	response regulator
EWA65_RS17815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWA65_RS17840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EWA65_RS17880	COG0745	RESPONSE REGULATOR receiver
EWA65_RS17905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EWA65_RS17910	COG0840	transmembrane signaling receptor activity
EWA65_RS17915	COG0835	chemotaxis
EWA65_RS17920	COG0835	chemotaxis
EWA65_RS17925	COG2198	Histidine kinase
EWA65_RS17925	COG0643	Histidine kinase
EWA65_RS17930	COG0745	RESPONSE REGULATOR receiver
EWA65_RS17940	COG2194	sulfuric ester hydrolase activity
EWA65_RS17945	COG0642	Histidine kinase
EWA65_RS17970	COG1022	Amp-dependent synthetase and ligase
EWA65_RS17980	COG1444	tRNA N-acetyltransferase activity
EWA65_RS17985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EWA65_RS18020	COG0217	transcriptional regulatory protein
EWA65_RS18025	COG2084	Dehydrogenase
EWA65_RS18040	COG2909	trisaccharide binding
EWA65_RS18045	COG0058	SHG alpha-glucan phosphorylase activity
EWA65_RS18050	COG1640	4-alpha-glucanotransferase
EWA65_RS18055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EWA65_RS18065	COG3501	Rhs element vgr protein
EWA65_RS18090	COG3385	transposase activity
EWA65_RS18105	COG0471	metal ion transport
EWA65_RS18110	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EWA65_RS18150	COG0671	phosphoesterase, PA-phosphatase related
EWA65_RS18155	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EWA65_RS18165	COG1999	signal sequence binding
EWA65_RS18180	COG0786	glutamate:sodium symporter activity
EWA65_RS18215	COG0813	purine-nucleoside phosphorylase activity
EWA65_RS18220	COG3272	Protein of unknown function (DUF1722)
EWA65_RS18225	COG0789	Transcriptional regulator
EWA65_RS18230	COG0415	Belongs to the DNA photolyase family
EWA65_RS18235	COG1376	ErfK ybiS ycfS ynhG family protein
EWA65_RS18235	COG1388	LysM domain
EWA65_RS18245	COG0513	Belongs to the DEAD box helicase family
EWA65_RS18250	COG1770	oligopeptidase
EWA65_RS18255	COG4771	TonB-dependent receptor
EWA65_RS18280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EWA65_RS18285	COG0573	inorganic phosphate transmembrane transporter activity
EWA65_RS18290	COG0581	inorganic phosphate transmembrane transporter activity
EWA65_RS18295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EWA65_RS18310	COG3314	Sporulation integral membrane protein YlbJ
EWA65_RS18315	COG0659	secondary active sulfate transmembrane transporter activity
EWA65_RS18325	COG0739	heme binding
EWA65_RS18330	COG5001	Diguanylate cyclase
EWA65_RS18330	COG3300	MHYT domain
EWA65_RS18335	COG0583	DNA-binding transcription factor activity
EWA65_RS18340	COG2814	Major facilitator Superfamily
EWA65_RS18360	COG0697	spore germination
EWA65_RS18365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EWA65_RS18370	COG1764	response to oxidative stress
EWA65_RS18375	COG1846	Transcriptional regulator
EWA65_RS18395	COG2207	Transcriptional regulator
EWA65_RS18400	COG1280	lysine exporter protein (LysE YggA)
EWA65_RS18410	COG1902	pentaerythritol trinitrate reductase activity
EWA65_RS18420	COG1132	(ABC) transporter
EWA65_RS18430	COG1902	pentaerythritol trinitrate reductase activity
EWA65_RS18440	COG0583	DNA-binding transcription factor activity
EWA65_RS18450	COG0800	Aldolase
EWA65_RS18455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA65_RS18460	COG1904	glucuronate isomerase
EWA65_RS18465	COG0246	Mannitol dehydrogenase
EWA65_RS18475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EWA65_RS18485	COG2186	Transcriptional regulator
EWA65_RS18495	COG0513	Belongs to the DEAD box helicase family
EWA65_RS18505	COG0747	negative chemotaxis
EWA65_RS18515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA65_RS18520	COG0444	Belongs to the ABC transporter superfamily
EWA65_RS18525	COG4608	Belongs to the ABC transporter superfamily
EWA65_RS18535	COG1609	Transcriptional regulator
EWA65_RS18550	COG4580	involved in the transport of maltose and maltodextrins
EWA65_RS18560	COG1472	Belongs to the glycosyl hydrolase 3 family
EWA65_RS18575	COG0840	transmembrane signaling receptor activity
EWA65_RS18590	COG0840	transmembrane signaling receptor activity
EWA65_RS18600	COG1914	H( )-stimulated, divalent metal cation uptake system
EWA65_RS18610	COG4580	involved in the transport of maltose and maltodextrins
EWA65_RS18625	COG0363	glucosamine-6-phosphate deaminase activity
EWA65_RS18650	COG2259	Doxx family
EWA65_RS18655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EWA65_RS18670	COG0471	metal ion transport
EWA65_RS18680	COG4565	transcriptional regulatory protein
EWA65_RS18685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EWA65_RS18690	COG3366	ferrous iron transmembrane transporter activity
EWA65_RS18695	COG0700	Nucleoside recognition
EWA65_RS18700	COG1301	dicarboxylic acid transport
EWA65_RS18715	COG1342	Belongs to the UPF0251 family
EWA65_RS18730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EWA65_RS18735	COG0673	inositol 2-dehydrogenase activity
EWA65_RS18740	COG0840	transmembrane signaling receptor activity
EWA65_RS18750	COG2771	luxR family
EWA65_RS18750	COG2200	EAL domain
EWA65_RS18755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3