locus-tag	class	description
GPY06_RS00025	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY06_RS00035	COG0861	Integral membrane protein TerC family
GPY06_RS00040	COG0737	Belongs to the 5'-nucleotidase family
GPY06_RS00045	COG3593	DNA synthesis involved in DNA repair
GPY06_RS00055	COG0583	DNA-binding transcription factor activity
GPY06_RS00060	COG2116	formate transmembrane transporter activity
GPY06_RS00070	COG3038	cytochrome b561
GPY06_RS00080	COG2200	EAL domain
GPY06_RS00095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY06_RS00110	COG0523	cobalamin synthesis protein
GPY06_RS00115	COG0038	chloride channel
GPY06_RS00125	COG0156	8-amino-7-oxononanoate synthase activity
GPY06_RS00130	COG2205	protein histidine kinase activity
GPY06_RS00130	COG0784	Response regulator, receiver
GPY06_RS00135	COG0419	ATPase involved in DNA repair
GPY06_RS00140	COG0420	3'-5' exonuclease activity
GPY06_RS00145	COG1609	Transcriptional regulator
GPY06_RS00150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS00150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS00155	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY06_RS00160	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY06_RS00160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS00160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS00165	COG4067	protein conserved in archaea
GPY06_RS00165	COG0189	ligase activity
GPY06_RS00175	COG0602	queuosine metabolic process
GPY06_RS00180	COG1328	CTP reductase activity
GPY06_RS00210	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPY06_RS00345	COG0456	acetyltransferase
GPY06_RS00515	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GPY06_RS01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY06_RS01165	COG0653	protein targeting
GPY06_RS01220	COG0384	phenazine biosynthesis protein PhzF
GPY06_RS01275	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY06_RS01305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPY06_RS01310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY06_RS01320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY06_RS01465	COG3772	lysozyme
GPY06_RS01555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY06_RS01565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY06_RS01570	COG0509	glycine decarboxylation via glycine cleavage system
GPY06_RS01575	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY06_RS01575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY06_RS01595	COG1686	Belongs to the peptidase S11 family
GPY06_RS01610	COG1414	Transcriptional regulator
GPY06_RS01620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY06_RS01640	COG0641	radical SAM
GPY06_RS01645	COG3119	arylsulfatase activity
GPY06_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
GPY06_RS01675	COG1085	galactose-1-phosphate uridylyltransferase
GPY06_RS01680	COG0800	Aldolase
GPY06_RS01685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY06_RS01700	COG0010	Belongs to the arginase family
GPY06_RS01705	COG1166	arginine decarboxylase activity
GPY06_RS01730	COG2239	Acts as a magnesium transporter
GPY06_RS01735	COG0527	aspartate kinase activity
GPY06_RS01740	COG0662	Cupin 2, conserved barrel domain protein
GPY06_RS01745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY06_RS01750	COG0456	acetyltransferase
GPY06_RS01765	COG0534	Mate efflux family protein
GPY06_RS01770	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY06_RS01775	COG3186	Phenylalanine-4-hydroxylase
GPY06_RS01780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY06_RS01795	COG2264	protein methyltransferase activity
GPY06_RS01800	COG0583	DNA-binding transcription factor activity
GPY06_RS01815	COG2171	N-acyltransferase activity
GPY06_RS01820	COG1253	flavin adenine dinucleotide binding
GPY06_RS01825	COG1765	OsmC-like protein
GPY06_RS01850	COG0531	amino acid
GPY06_RS01855	COG3706	GGDEF domain
GPY06_RS01865	COG3279	Response regulator of the LytR AlgR family
GPY06_RS01870	COG3275	phosphorelay sensor kinase activity
GPY06_RS01890	COG1136	(ABC) transporter
GPY06_RS01900	COG4989	oxidoreductase activity
GPY06_RS01905	COG0366	Alpha amylase catalytic
GPY06_RS01910	COG2067	long-chain fatty acid transport protein
GPY06_RS01920	COG3227	Zinc metalloprotease (Elastase)
GPY06_RS01925	COG3047	cAMP biosynthetic process
GPY06_RS01935	COG1686	Belongs to the peptidase S11 family
GPY06_RS01955	COG1063	alcohol dehydrogenase
GPY06_RS01965	COG2873	o-acetylhomoserine
GPY06_RS01975	COG0346	lactoylglutathione lyase activity
GPY06_RS01995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY06_RS02000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY06_RS02005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY06_RS02010	COG0363	glucosamine-6-phosphate deaminase activity
GPY06_RS02015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY06_RS02040	COG1929	Belongs to the glycerate kinase type-1 family
GPY06_RS02050	COG0748	coenzyme F420 binding
GPY06_RS02055	COG3721	Heme iron utilization protein
GPY06_RS02065	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY06_RS02070	COG0811	peptide transport
GPY06_RS02075	COG0848	biopolymer transport protein
GPY06_RS02085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY06_RS02090	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY06_RS02125	COG0633	Ferredoxin
GPY06_RS02125	COG3217	Mosc domain protein beta barrel domain protein
GPY06_RS02125	COG3217	Mosc domain protein beta barrel domain protein
GPY06_RS02125	COG0633	Ferredoxin
GPY06_RS02130	COG0418	dihydroorotase activity
GPY06_RS02135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY06_RS02140	COG2354	Protein conserved in bacteria
GPY06_RS02145	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY06_RS02150	COG1278	Cold shock
GPY06_RS02170	COG3706	GGDEF domain
GPY06_RS02175	COG1349	DNA-binding transcription factor activity
GPY06_RS02190	COG3833	ABC-type maltose transport systems, permease component
GPY06_RS02195	COG1175	transmembrane transport
GPY06_RS02205	COG3842	ATPase activity
GPY06_RS02210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY06_RS02225	COG0393	Putative heavy-metal-binding
GPY06_RS02235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY06_RS02240	COG0784	Response regulator, receiver
GPY06_RS02240	COG0835	chemotaxis
GPY06_RS02245	COG1846	Transcriptional regulator
GPY06_RS02265	COG3706	GGDEF domain
GPY06_RS02285	COG0583	DNA-binding transcription factor activity
GPY06_RS02290	COG5001	Diguanylate cyclase
GPY06_RS02300	COG1741	Belongs to the pirin family
GPY06_RS02305	COG3123	guanosine phosphorylase activity
GPY06_RS02315	COG2211	Major facilitator Superfamily
GPY06_RS02325	COG1067	ATP-dependent peptidase activity
GPY06_RS02335	COG4172	Belongs to the ABC transporter superfamily
GPY06_RS02355	COG0583	DNA-binding transcription factor activity
GPY06_RS02360	COG1620	l-lactate permease
GPY06_RS02365	COG1304	FMN binding
GPY06_RS02375	COG0840	transmembrane signaling receptor activity
GPY06_RS02380	COG0840	transmembrane signaling receptor activity
GPY06_RS02385	COG0534	Mate efflux family protein
GPY06_RS02390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY06_RS02395	COG1126	abc transporter atp-binding protein
GPY06_RS02405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY06_RS02410	COG4597	amino acid ABC transporter
GPY06_RS02415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY06_RS02425	COG0739	heme binding
GPY06_RS02430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS02430	COG2213	PTS system mannitol-specific
GPY06_RS02435	COG0246	Mannitol dehydrogenase
GPY06_RS02440	COG3722	fumarate hydratase activity
GPY06_RS02445	COG0673	inositol 2-dehydrogenase activity
GPY06_RS02480	COG2910	NAD(P)H-binding
GPY06_RS02495	COG4221	oxidoreductase activity
GPY06_RS02505	COG1901	pseudouridine methyltransferase
GPY06_RS02510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY06_RS02515	COG0531	amino acid
GPY06_RS02520	COG1982	Orn Lys Arg decarboxylase major
GPY06_RS02550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY06_RS02575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY06_RS02585	COG0259	pyridoxamine-phosphate oxidase activity
GPY06_RS02635	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPY06_RS02640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY06_RS02645	COG0840	transmembrane signaling receptor activity
GPY06_RS02650	COG0835	chemotaxis
GPY06_RS02655	COG0835	chemotaxis
GPY06_RS02660	COG2198	Histidine kinase
GPY06_RS02660	COG0643	Histidine kinase
GPY06_RS02665	COG0745	RESPONSE REGULATOR receiver
GPY06_RS02675	COG2194	sulfuric ester hydrolase activity
GPY06_RS02680	COG0642	Histidine kinase
GPY06_RS02685	COG0745	RESPONSE REGULATOR receiver
GPY06_RS02705	COG1022	Amp-dependent synthetase and ligase
GPY06_RS02715	COG1444	tRNA N-acetyltransferase activity
GPY06_RS02720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY06_RS02755	COG0217	transcriptional regulatory protein
GPY06_RS02760	COG2084	Dehydrogenase
GPY06_RS02775	COG2909	trisaccharide binding
GPY06_RS02780	COG0058	SHG alpha-glucan phosphorylase activity
GPY06_RS02785	COG1640	4-alpha-glucanotransferase
GPY06_RS02790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY06_RS02800	COG3501	Rhs element vgr protein
GPY06_RS02835	COG0471	metal ion transport
GPY06_RS02840	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY06_RS02880	COG0671	phosphoesterase, PA-phosphatase related
GPY06_RS02885	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY06_RS02895	COG1999	signal sequence binding
GPY06_RS02910	COG0786	glutamate:sodium symporter activity
GPY06_RS02930	COG3706	GGDEF domain
GPY06_RS02945	COG0813	purine-nucleoside phosphorylase activity
GPY06_RS02950	COG3272	Protein of unknown function (DUF1722)
GPY06_RS02955	COG0789	Transcriptional regulator
GPY06_RS02965	COG1388	LysM domain
GPY06_RS02965	COG1376	ErfK ybiS ycfS ynhG family protein
GPY06_RS02975	COG0513	Belongs to the DEAD box helicase family
GPY06_RS02980	COG1770	oligopeptidase
GPY06_RS02985	COG4771	TonB-dependent receptor
GPY06_RS03005	COG0840	transmembrane signaling receptor activity
GPY06_RS03010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY06_RS03015	COG0573	inorganic phosphate transmembrane transporter activity
GPY06_RS03020	COG0581	inorganic phosphate transmembrane transporter activity
GPY06_RS03025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY06_RS03045	COG0659	secondary active sulfate transmembrane transporter activity
GPY06_RS03055	COG0739	heme binding
GPY06_RS03060	COG5001	Diguanylate cyclase
GPY06_RS03060	COG3300	MHYT domain
GPY06_RS03065	COG0583	DNA-binding transcription factor activity
GPY06_RS03070	COG2814	Major facilitator Superfamily
GPY06_RS03090	COG0697	spore germination
GPY06_RS03095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY06_RS03100	COG1764	response to oxidative stress
GPY06_RS03105	COG1846	Transcriptional regulator
GPY06_RS03125	COG2207	Transcriptional regulator
GPY06_RS03130	COG1280	lysine exporter protein (LysE YggA)
GPY06_RS03140	COG1902	pentaerythritol trinitrate reductase activity
GPY06_RS03150	COG1132	(ABC) transporter
GPY06_RS03160	COG1902	pentaerythritol trinitrate reductase activity
GPY06_RS03170	COG0583	DNA-binding transcription factor activity
GPY06_RS03180	COG0800	Aldolase
GPY06_RS03185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY06_RS03190	COG1904	glucuronate isomerase
GPY06_RS03195	COG0246	Mannitol dehydrogenase
GPY06_RS03205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY06_RS03215	COG2186	Transcriptional regulator
GPY06_RS03225	COG0513	Belongs to the DEAD box helicase family
GPY06_RS03235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY06_RS03250	COG0840	transmembrane signaling receptor activity
GPY06_RS03265	COG0840	transmembrane signaling receptor activity
GPY06_RS03275	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY06_RS03285	COG4580	involved in the transport of maltose and maltodextrins
GPY06_RS03300	COG0363	glucosamine-6-phosphate deaminase activity
GPY06_RS03325	COG2259	Doxx family
GPY06_RS03330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY06_RS03345	COG0471	metal ion transport
GPY06_RS03355	COG4565	transcriptional regulatory protein
GPY06_RS03360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY06_RS03365	COG3366	ferrous iron transmembrane transporter activity
GPY06_RS03370	COG0700	Nucleoside recognition
GPY06_RS03375	COG1301	dicarboxylic acid transport
GPY06_RS03390	COG1342	Belongs to the UPF0251 family
GPY06_RS03405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY06_RS03410	COG0673	inositol 2-dehydrogenase activity
GPY06_RS03415	COG0840	transmembrane signaling receptor activity
GPY06_RS03425	COG2200	EAL domain
GPY06_RS03430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY06_RS03535	COG3501	Rhs element vgr protein
GPY06_RS03550	COG1869	D-ribose catabolic process
GPY06_RS03555	COG1129	ABC transporter
GPY06_RS03560	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY06_RS03565	COG1879	ABC-type sugar transport system periplasmic component
GPY06_RS03570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY06_RS03575	COG1609	Transcriptional regulator
GPY06_RS03580	COG5002	protein histidine kinase activity
GPY06_RS03580	COG5001	Diguanylate cyclase
GPY06_RS03580	COG3447	MASE1 domain protein
GPY06_RS03590	COG0584	glycerophosphoryl diester phosphodiesterase
GPY06_RS03595	COG2271	Major facilitator Superfamily
GPY06_RS03635	COG0579	oxidoreductase
GPY06_RS03655	COG0488	(ABC) transporter
GPY06_RS03660	COG0814	amino acid
GPY06_RS03665	COG3033	Beta-eliminating lyase
GPY06_RS03675	COG3530	Putative quorum-sensing-regulated virulence factor
GPY06_RS03690	COG1278	Cold shock
GPY06_RS03705	COG2304	oxidoreductase activity
GPY06_RS03725	COG0714	Associated with various cellular activities
GPY06_RS03730	COG0840	transmembrane signaling receptor activity
GPY06_RS03745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY06_RS03750	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY06_RS03760	COG3604	Transcriptional regulator
GPY06_RS03765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY06_RS03765	COG1017	nitric oxide dioxygenase activity
GPY06_RS03770	COG1278	Cold shock
GPY06_RS03800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY06_RS03800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY06_RS03805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY06_RS03815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY06_RS03825	COG0516	GMP reductase activity
GPY06_RS03830	COG4974	Belongs to the 'phage' integrase family
GPY06_RS03925	COG4695	Portal protein
GPY06_RS04050	COG0513	Belongs to the DEAD box helicase family
GPY06_RS04055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY06_RS04060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY06_RS04065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY06_RS04070	COG0840	transmembrane signaling receptor activity
GPY06_RS04075	COG3437	response regulator, receiver
GPY06_RS04075	COG0784	Response regulator, receiver
GPY06_RS04080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY06_RS04080	COG4191	Histidine kinase
GPY06_RS04090	COG1757	Na H antiporter
GPY06_RS04095	COG2814	Major facilitator Superfamily
GPY06_RS04105	COG3706	GGDEF domain
GPY06_RS04110	COG3240	lipase activity
GPY06_RS04120	COG0840	transmembrane signaling receptor activity
GPY06_RS04125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY06_RS04130	COG5380	lipid catabolic process
GPY06_RS04135	COG4412	M6 family metalloprotease domain protein
GPY06_RS04135	COG3291	Pkd domain containing protein
GPY06_RS04155	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY06_RS04160	COG4605	iron ion homeostasis
GPY06_RS04165	COG4604	ABC transporter, ATP-binding protein
GPY06_RS04185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY06_RS04215	COG3623	hexulose-6-phosphate isomerase
GPY06_RS04220	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPY06_RS04225	COG0561	phosphatase activity
GPY06_RS04270	COG0745	RESPONSE REGULATOR receiver
GPY06_RS04275	COG5002	protein histidine kinase activity
GPY06_RS04290	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY06_RS04315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY06_RS04325	COG3397	chitin binding
GPY06_RS04330	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY06_RS04340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY06_RS04350	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY06_RS04355	COG0513	Belongs to the DEAD box helicase family
GPY06_RS04360	COG1943	Transposase
GPY06_RS04370	COG1368	sulfuric ester hydrolase activity
GPY06_RS04375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY06_RS04435	COG0484	heat shock protein binding
GPY06_RS04445	COG1716	ATPase activity
GPY06_RS04445	COG5001	Diguanylate cyclase
GPY06_RS04450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY06_RS04460	COG4181	ATPase activity
GPY06_RS04465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY06_RS04480	COG1984	allophanate hydrolase subunit 2
GPY06_RS04485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY06_RS04490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY06_RS04495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY06_RS04500	COG0840	transmembrane signaling receptor activity
GPY06_RS04505	COG0814	amino acid
GPY06_RS04510	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY06_RS04515	COG0513	Belongs to the DEAD box helicase family
GPY06_RS04520	COG1309	transcriptional regulator
GPY06_RS04530	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY06_RS04535	COG0494	nUDIX hydrolase
GPY06_RS04545	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY06_RS04555	COG1126	abc transporter atp-binding protein
GPY06_RS04560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY06_RS04565	COG4215	(ABC) transporter
GPY06_RS04570	COG4160	amino acid transport
GPY06_RS04590	COG0840	transmembrane signaling receptor activity
GPY06_RS04610	COG3118	belongs to the thioredoxin family
GPY06_RS04615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY06_RS04620	COG0247	lactate metabolic process
GPY06_RS04625	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY06_RS04630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY06_RS04635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY06_RS04640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY06_RS04670	COG2827	Endonuclease containing a URI domain
GPY06_RS04680	COG1879	ABC-type sugar transport system periplasmic component
GPY06_RS04685	COG5002	protein histidine kinase activity
GPY06_RS04685	COG0784	Response regulator, receiver
GPY06_RS04710	COG0582	viral genome integration into host DNA
GPY06_RS04720	COG2404	hydrolase activity, acting on ester bonds
GPY06_RS04975	COG1492	cobalamin metabolic process
GPY06_RS04980	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY06_RS04985	COG4149	molybdate abc transporter
GPY06_RS04990	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY06_RS05020	COG1289	transmembrane transporter activity
GPY06_RS05025	COG0210	DNA helicase
GPY06_RS05030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY06_RS05035	COG1335	isochorismatase
GPY06_RS05040	COG1803	Methylglyoxal synthase
GPY06_RS05045	COG1879	ABC-type sugar transport system periplasmic component
GPY06_RS05055	COG0469	pyruvate kinase activity
GPY06_RS05060	COG2271	Major facilitator Superfamily
GPY06_RS05065	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY06_RS05070	COG4191	Histidine kinase
GPY06_RS05085	COG1979	alcohol dehydrogenase
GPY06_RS05095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY06_RS05100	COG3706	GGDEF domain
GPY06_RS05115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY06_RS05130	COG0183	Belongs to the thiolase family
GPY06_RS05140	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY06_RS05145	COG3842	ATPase activity
GPY06_RS05155	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY06_RS05160	COG2271	Major facilitator Superfamily
GPY06_RS05165	COG3851	Histidine kinase
GPY06_RS05170	COG2197	response regulator
GPY06_RS05175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY06_RS05185	COG3005	denitrification pathway
GPY06_RS05195	COG0243	molybdopterin cofactor binding
GPY06_RS05205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY06_RS05210	COG3850	Histidine kinase
GPY06_RS05215	COG2197	response regulator
GPY06_RS05220	COG1760	l-serine dehydratase
GPY06_RS05225	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY06_RS05230	COG0840	transmembrane signaling receptor activity
GPY06_RS05235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY06_RS05240	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY06_RS05245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GPY06_RS05245	COG2885	chlorophyll binding
GPY06_RS05250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY06_RS05255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY06_RS05260	COG1621	beta-fructofuranosidase activity
GPY06_RS05325	COG0640	Transcriptional regulator
GPY06_RS05335	COG2391	methyltransferase activity
GPY06_RS05360	COG0583	DNA-binding transcription factor activity
GPY06_RS05380	COG1335	isochorismatase
GPY06_RS05390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY06_RS05400	COG0583	DNA-binding transcription factor activity
GPY06_RS05405	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY06_RS05415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY06_RS05420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY06_RS05425	COG2390	Transcriptional regulator
GPY06_RS05435	COG2897	thiosulfate sulfurtransferase activity
GPY06_RS05445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY06_RS05455	COG0302	gtp cyclohydrolase
GPY06_RS05460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY06_RS05460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY06_RS05465	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY06_RS05470	COG1970	mechanosensitive ion channel activity
GPY06_RS05475	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY06_RS05485	COG1011	Hydrolase
GPY06_RS05490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY06_RS05495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY06_RS05505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY06_RS05510	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY06_RS05515	COG3842	ATPase activity
GPY06_RS05560	COG4166	transmembrane transport
GPY06_RS05565	COG4174	ABC transporter (Permease)
GPY06_RS05575	COG4172	Belongs to the ABC transporter superfamily
GPY06_RS05580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY06_RS05595	COG0625	glutathione transferase activity
GPY06_RS05610	COG0501	Belongs to the peptidase M48B family
GPY06_RS05615	COG2050	protein possibly involved in aromatic compounds catabolism
GPY06_RS05630	COG4771	TonB-dependent receptor
GPY06_RS05635	COG0583	DNA-binding transcription factor activity
GPY06_RS05640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY06_RS05640	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY06_RS05640	COG1042	CoA-binding domain protein
GPY06_RS05650	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY06_RS05660	COG0023	Translation Initiation Factor
GPY06_RS05705	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY06_RS05710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY06_RS05725	COG3706	GGDEF domain
GPY06_RS05745	COG3706	GGDEF domain
GPY06_RS05770	COG2205	protein histidine kinase activity
GPY06_RS05770	COG0784	Response regulator, receiver
GPY06_RS05785	COG3120	sequence-specific DNA binding
GPY06_RS05790	COG1067	ATP-dependent peptidase activity
GPY06_RS05795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY06_RS05820	COG0116	Belongs to the methyltransferase superfamily
GPY06_RS05820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY06_RS05830	COG0167	dihydroorotate dehydrogenase activity
GPY06_RS05835	COG2902	Dehydrogenase
GPY06_RS05845	COG0308	aminopeptidase N
GPY06_RS05860	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY06_RS05865	COG1956	GAF domain-containing protein
GPY06_RS05870	COG1132	(ABC) transporter
GPY06_RS05875	COG2995	paraquat-inducible protein a
GPY06_RS05880	COG3008	intermembrane lipid transfer
GPY06_RS05885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY06_RS05885	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY06_RS05890	COG2996	Protein conserved in bacteria
GPY06_RS05905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY06_RS05915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY06_RS05920	COG0004	ammonium transporteR
GPY06_RS05935	COG0437	4 iron, 4 sulfur cluster binding
GPY06_RS05940	COG0243	molybdopterin cofactor binding
GPY06_RS05940	COG3383	formate dehydrogenase (NAD+) activity
GPY06_RS05970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY06_RS05975	COG0488	(ABC) transporter
GPY06_RS05980	COG3852	Histidine kinase
GPY06_RS05985	COG2204	response regulator
GPY06_RS05995	COG4662	Binding-protein-dependent transport system inner membrane component
GPY06_RS06000	COG3842	ATPase activity
GPY06_RS06005	COG0746	molybdenum cofactor guanylyltransferase activity
GPY06_RS06010	COG0303	'Molybdopterin
GPY06_RS06020	COG1940	carbohydrate kinase activity
GPY06_RS06035	COG0840	transmembrane signaling receptor activity
GPY06_RS06040	COG0791	NLP P60 protein
GPY06_RS06060	COG0534	Mate efflux family protein
GPY06_RS06070	COG1793	dna ligase
GPY06_RS06085	COG0848	biopolymer transport protein
GPY06_RS06090	COG0811	peptide transport
GPY06_RS06095	COG0811	peptide transport
GPY06_RS06115	COG0395	ABC-type sugar transport system, permease component
GPY06_RS06120	COG3842	ATPase activity
GPY06_RS06125	COG1349	DNA-binding transcription factor activity
GPY06_RS06130	COG0584	glycerophosphoryl diester phosphodiesterase
GPY06_RS06135	COG2731	YhcH YjgK YiaL family protein
GPY06_RS06140	COG0251	oxidation-reduction process
GPY06_RS06145	COG1609	Transcriptional regulator
GPY06_RS06150	COG2723	6-phospho-beta-galactosidase activity
GPY06_RS06155	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY06_RS06160	COG1943	Transposase
GPY06_RS06185	COG1136	(ABC) transporter
GPY06_RS06185	COG0577	efflux transmembrane transporter activity
GPY06_RS06190	COG1136	(ABC) transporter
GPY06_RS06190	COG0577	efflux transmembrane transporter activity
GPY06_RS06195	COG1136	(ABC) transporter
GPY06_RS06195	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY06_RS06200	COG1294	oxidase, subunit
GPY06_RS06205	COG1271	oxidase subunit
GPY06_RS06260	COG0753	catalase activity
GPY06_RS06285	COG0493	'glutamate synthase
GPY06_RS06295	COG0398	Pfam SNARE associated Golgi protein
GPY06_RS06300	COG4135	transport system, permease component
GPY06_RS06305	COG2200	EAL domain
GPY06_RS06305	COG2199	diguanylate cyclase activity
GPY06_RS06310	COG3706	GGDEF domain
GPY06_RS06315	COG2017	converts alpha-aldose to the beta-anomer
GPY06_RS06320	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY06_RS06345	COG0745	RESPONSE REGULATOR receiver
GPY06_RS06345	COG3706	GGDEF domain
GPY06_RS06360	COG0835	chemotaxis
GPY06_RS06360	COG0784	Response regulator, receiver
GPY06_RS06370	COG4565	transcriptional regulatory protein
GPY06_RS06375	COG3290	protein histidine kinase activity
GPY06_RS06390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY06_RS06410	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY06_RS06415	COG3063	Type IV pilus biogenesis stability protein PilW
GPY06_RS06430	COG1451	nucleotide metabolic process
GPY06_RS06440	COG0583	DNA-binding transcription factor activity
GPY06_RS06465	COG1538	Outer membrane efflux protein
GPY06_RS06475	COG0019	diaminopimelate decarboxylase activity
GPY06_RS06480	COG1748	Saccharopine dehydrogenase
GPY06_RS06490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY06_RS06505	COG4181	ATPase activity
GPY06_RS06510	COG0534	Mate efflux family protein
GPY06_RS06515	COG0702	epimerase
GPY06_RS06525	COG2814	Major facilitator Superfamily
GPY06_RS06530	COG1187	pseudouridine synthase activity
GPY06_RS06535	COG1061	Type III restriction enzyme res subunit
GPY06_RS06545	COG0745	RESPONSE REGULATOR receiver
GPY06_RS06550	COG5002	protein histidine kinase activity
GPY06_RS06555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY06_RS06570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY06_RS06605	COG4934	collagen metabolic process
GPY06_RS06625	COG2239	Acts as a magnesium transporter
GPY06_RS06635	COG0814	amino acid
GPY06_RS06645	COG1131	(ABC) transporter
GPY06_RS06650	COG0842	Transport permease protein
GPY06_RS06660	COG3313	Fe-S protein
GPY06_RS06670	COG4134	Bacterial extracellular solute-binding protein
GPY06_RS06675	COG4135	transport system, permease component
GPY06_RS06680	COG4136	ATPase activity
GPY06_RS06685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY06_RS06690	COG0564	pseudouridine synthase activity
GPY06_RS06695	COG0733	neurotransmitter:sodium symporter activity
GPY06_RS06705	COG0626	cystathionine gamma-synthase activity
GPY06_RS06710	COG2818	Glycosylase
GPY06_RS06725	COG1842	Phage shock protein A
GPY06_RS06740	COG4168	peptide transport system, permease
GPY06_RS06745	COG4171	peptide transport system, permease
GPY06_RS06755	COG4172	Belongs to the ABC transporter superfamily
GPY06_RS06775	COG1227	inorganic diphosphatase activity
GPY06_RS06780	COG1162	GTPase activity
GPY06_RS06795	COG0243	molybdopterin cofactor binding
GPY06_RS06800	COG3005	denitrification pathway
GPY06_RS06805	COG4459	periplasmic nitrate reductase
GPY06_RS06810	COG2116	formate transmembrane transporter activity
GPY06_RS06820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY06_RS06825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY06_RS06840	COG2917	probably involved in intracellular septation
GPY06_RS06845	COG1607	acyl-coa hydrolase
GPY06_RS06850	COG2350	Protein conserved in bacteria
GPY06_RS06860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY06_RS06865	COG0583	DNA-binding transcription factor activity
GPY06_RS06880	COG0612	Peptidase, M16
GPY06_RS06885	COG2200	EAL domain
GPY06_RS06885	COG2199	diguanylate cyclase activity
GPY06_RS06885	COG2203	Gaf domain
GPY06_RS06890	COG1032	radical SAM domain protein
GPY06_RS06910	COG2207	Transcriptional regulator
GPY06_RS06915	COG1979	alcohol dehydrogenase
GPY06_RS06920	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY06_RS06925	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY06_RS06930	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY06_RS06935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY06_RS06940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY06_RS06945	COG0745	RESPONSE REGULATOR receiver
GPY06_RS06950	COG3381	protein complex oligomerization
GPY06_RS06955	COG1609	Transcriptional regulator
GPY06_RS06960	COG3070	regulator of competence-specific genes
GPY06_RS06965	COG1943	Transposase
GPY06_RS06985	COG0297	glycogen (starch) synthase activity
GPY06_RS06990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY06_RS06995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY06_RS07005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY06_RS07010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY06_RS07015	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY06_RS07020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY06_RS07025	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY06_RS07050	COG1012	belongs to the aldehyde dehydrogenase family
GPY06_RS07065	COG0668	transmembrane transport
GPY06_RS07070	COG2995	paraquat-inducible protein a
GPY06_RS07075	COG3008	intermembrane lipid transfer
GPY06_RS07075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY06_RS07105	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY06_RS07110	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY06_RS07135	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY06_RS07140	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY06_RS07145	COG1737	Transcriptional regulator
GPY06_RS07150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY06_RS07155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY06_RS07160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY06_RS07165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY06_RS07175	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPY06_RS07180	COG1940	carbohydrate kinase activity
GPY06_RS07185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY06_RS07190	COG4409	exo-alpha-(2->6)-sialidase activity
GPY06_RS07205	COG4628	conserved protein (DUF2132)
GPY06_RS07215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS07215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS07215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS07220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS07225	COG3537	Alpha-1,2-mannosidase
GPY06_RS07230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS07235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS07245	COG2207	Transcriptional regulator
GPY06_RS07250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS07250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS07250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY06_RS07265	COG0784	Response regulator, receiver
GPY06_RS07265	COG5002	protein histidine kinase activity
GPY06_RS07275	COG1943	Transposase
GPY06_RS07280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY06_RS07290	COG2885	chlorophyll binding
GPY06_RS07295	COG0823	Involved in the tonB-independent uptake of proteins
GPY06_RS07310	COG0811	peptide transport
GPY06_RS07315	COG0824	Thioesterase
GPY06_RS07320	COG3790	cyd operon protein YbgE
GPY06_RS07325	COG4890	Cyd operon protein YbgT
GPY06_RS07330	COG1294	oxidase, subunit
GPY06_RS07335	COG1271	oxidase subunit
GPY06_RS07340	COG2255	four-way junction helicase activity
GPY06_RS07345	COG0632	four-way junction helicase activity
GPY06_RS07350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY06_RS07355	COG0215	cysteine-tRNA ligase activity
GPY06_RS07360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY06_RS07365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY06_RS07370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY06_RS07390	COG1199	ATP-dependent helicase activity
GPY06_RS07395	COG0730	response to heat
GPY06_RS07400	COG3923	Primosomal replication protein n
GPY06_RS07410	COG0840	transmembrane signaling receptor activity
GPY06_RS07415	COG0708	Exodeoxyribonuclease III
GPY06_RS07420	COG4160	amino acid transport
GPY06_RS07425	COG4215	(ABC) transporter
GPY06_RS07445	COG1882	Formate acetyltransferase
GPY06_RS07455	COG0840	transmembrane signaling receptor activity
GPY06_RS07460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY06_RS07470	COG3013	Belongs to the UPF0304 family
GPY06_RS07475	COG2766	serine protein kinase
GPY06_RS07480	COG2718	Belongs to the UPF0229 family
GPY06_RS07485	COG2719	SpoVR family
GPY06_RS07490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY06_RS07500	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY06_RS07505	COG1132	(ABC) transporter
GPY06_RS07510	COG0658	competence protein
GPY06_RS07510	COG2333	competence protein COMEC
GPY06_RS07520	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY06_RS07525	COG1136	(ABC) transporter
GPY06_RS07530	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY06_RS07540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY06_RS07560	COG1252	NADH dehydrogenase
GPY06_RS07590	COG0537	adenosine 5'-monophosphoramidase activity
GPY06_RS07605	COG2186	Transcriptional regulator
GPY06_RS07610	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY06_RS07615	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY06_RS07625	COG1522	sequence-specific DNA binding
GPY06_RS07630	COG0686	Belongs to the AlaDH PNT family
GPY06_RS07640	COG0583	DNA-binding transcription factor activity
GPY06_RS07655	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY06_RS07660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY06_RS07665	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY06_RS07670	COG0776	regulation of translation
GPY06_RS07675	COG0539	negative regulation of cytoplasmic translation
GPY06_RS07680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY06_RS07685	COG1555	photosystem II stabilization
GPY06_RS07690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY06_RS07695	COG0776	regulation of translation
GPY06_RS07700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY06_RS07705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY06_RS07715	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY06_RS07725	COG4191	Histidine kinase
GPY06_RS07735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY06_RS07740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY06_RS07745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY06_RS07750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY06_RS07765	COG5001	Diguanylate cyclase
GPY06_RS07765	COG3300	MHYT domain
GPY06_RS07775	COG4589	Belongs to the CDS family
GPY06_RS07790	COG0671	phosphoesterase, PA-phosphatase related
GPY06_RS07805	COG3842	ATPase activity
GPY06_RS07850	COG1120	ATPase activity
GPY06_RS07855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY06_RS07895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY06_RS07900	COG0243	molybdopterin cofactor binding
GPY06_RS07905	COG3005	denitrification pathway
GPY06_RS07910	COG3325	Belongs to the glycosyl hydrolase 18 family
GPY06_RS07910	COG3469	chitinase activity
GPY06_RS07915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY06_RS07925	COG2951	lytic endotransglycosylase activity
GPY06_RS07930	COG3100	YcgL domain-containing protein
GPY06_RS07940	COG2894	cell division
GPY06_RS07945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY06_RS07950	COG3015	lipoprotein NlpE involved in copper resistance
GPY06_RS07975	COG3135	benzoate transporter
GPY06_RS07985	COG1441	menaquinone biosynthetic process
GPY06_RS07995	COG0596	Alpha beta hydrolase
GPY06_RS08000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY06_RS08005	COG1169	isochorismate synthase
GPY06_RS08010	COG0436	Aminotransferase
GPY06_RS08015	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY06_RS08020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY06_RS08035	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY06_RS08040	COG0318	PFAM AMP-dependent synthetase and ligase
GPY06_RS08045	COG0596	Alpha beta hydrolase
GPY06_RS08060	COG1214	PFAM Peptidase M22, glycoprotease
GPY06_RS08065	COG1199	ATP-dependent helicase activity
GPY06_RS08075	COG0788	formyltetrahydrofolate deformylase activity
GPY06_RS08080	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY06_RS08080	COG1902	pentaerythritol trinitrate reductase activity
GPY06_RS08085	COG0616	signal peptide processing
GPY06_RS08090	COG0252	asparaginase activity
GPY06_RS08095	COG3139	Protein of unknown function (DUF1315)
GPY06_RS08105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY06_RS08110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY06_RS08115	COG0676	glucose-6-phosphate 1-epimerase activity
GPY06_RS08125	COG2226	methyltransferase
GPY06_RS08155	COG0784	Response regulator, receiver
GPY06_RS08155	COG0835	chemotaxis
GPY06_RS08160	COG1940	carbohydrate kinase activity
GPY06_RS08170	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY06_RS08185	COG0733	neurotransmitter:sodium symporter activity
GPY06_RS08200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY06_RS08200	COG1263	PTS System
GPY06_RS08205	COG0084	hydrolase, TatD family'
GPY06_RS08210	COG0470	DNA polymerase III
GPY06_RS08215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY06_RS08220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY06_RS08225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY06_RS08230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY06_RS08235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY06_RS08250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY06_RS08255	COG0416	fatty acid biosynthetic process
GPY06_RS08260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPY06_RS08265	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY06_RS08270	COG0424	maF-like protein
GPY06_RS08275	COG0564	pseudouridine synthase activity
GPY06_RS08280	COG1530	ribonuclease E activity
GPY06_RS08285	COG0659	secondary active sulfate transmembrane transporter activity
GPY06_RS08295	COG1012	belongs to the aldehyde dehydrogenase family
GPY06_RS08295	COG1454	alcohol dehydrogenase
GPY06_RS08300	COG2095	MarC family integral membrane protein
GPY06_RS08305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY06_RS08310	COG1757	Na H antiporter
GPY06_RS08320	COG3081	Nucleoid-associated protein
GPY06_RS08330	COG3083	sulfuric ester hydrolase activity
GPY06_RS08345	COG0582	viral genome integration into host DNA
GPY06_RS08410	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY06_RS08415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY06_RS08420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY06_RS08440	COG2853	Lipoprotein
GPY06_RS08450	COG3088	subunit of a heme lyase
GPY06_RS08450	COG4235	cytochrome complex assembly
GPY06_RS08455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY06_RS08460	COG1138	Cytochrome C-type biogenesis protein
GPY06_RS08465	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY06_RS08475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY06_RS08480	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY06_RS08485	COG4133	protoheme IX ABC transporter activity
GPY06_RS08495	COG0835	chemotaxis
GPY06_RS08505	COG1192	Involved in chromosome partitioning
GPY06_RS08510	COG2201	protein-glutamate methylesterase activity
GPY06_RS08515	COG2198	Histidine kinase
GPY06_RS08515	COG0643	Histidine kinase
GPY06_RS08520	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY06_RS08535	COG0455	bacterial-type flagellum organization
GPY06_RS08550	COG2062	phosphohistidine phosphatase, SixA
GPY06_RS08555	COG1025	Belongs to the peptidase M16 family
GPY06_RS08565	COG0018	arginyl-trna synthetase
GPY06_RS08585	COG1918	ferrous iron import across plasma membrane
GPY06_RS08590	COG4977	sequence-specific DNA binding
GPY06_RS08595	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY06_RS08600	COG1121	(ABC) transporter
GPY06_RS08605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY06_RS08615	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY06_RS08620	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY06_RS08625	COG0567	Dehydrogenase, E1 component
GPY06_RS08635	COG1053	succinate dehydrogenase
GPY06_RS08640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY06_RS08645	COG2009	succinate dehydrogenase
GPY06_RS08650	COG0372	Belongs to the citrate synthase family
GPY06_RS08655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY06_RS08665	COG0033	Phosphoglucomutase
GPY06_RS08670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY06_RS08675	COG0596	Alpha beta hydrolase
GPY06_RS08690	COG1346	cytolysis
GPY06_RS08700	COG0583	DNA-binding transcription factor activity
GPY06_RS08710	COG0735	belongs to the Fur family
GPY06_RS08715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY06_RS08720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY06_RS08725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY06_RS08730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY06_RS08730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY06_RS08735	COG0431	NADPH-dependent FMN reductase
GPY06_RS08745	COG3101	peptidyl-lysine hydroxylation
GPY06_RS08750	COG2860	membrane
GPY06_RS08755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY06_RS08760	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY06_RS08780	COG1987	bacterial-type flagellum assembly
GPY06_RS08825	COG1317	bacterial-type flagellum organization
GPY06_RS08830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY06_RS08845	COG2204	response regulator
GPY06_RS08850	COG4191	Histidine kinase
GPY06_RS08855	COG2204	response regulator
GPY06_RS08860	COG1516	flagellar protein fliS
GPY06_RS08870	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY06_RS08875	COG1334	flagellar protein FlaG
GPY06_RS08880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY06_RS08885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY06_RS08890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY06_RS08895	COG2837	iron assimilation
GPY06_RS08915	COG1393	Belongs to the ArsC family
GPY06_RS08920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY06_RS08925	COG1876	peptidase activity
GPY06_RS08935	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY06_RS08940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY06_RS08950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY06_RS08970	COG4783	chaperone-mediated protein folding
GPY06_RS08975	COG1393	Belongs to the ArsC family
GPY06_RS09000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY06_RS09005	COG0737	Belongs to the 5'-nucleotidase family
GPY06_RS09010	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY06_RS09015	COG2912	Transglutaminase-like superfamily
GPY06_RS09020	COG3094	Invasion gene expression up-regulator, SirB
GPY06_RS09025	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY06_RS09030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY06_RS09035	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY06_RS09040	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY06_RS09045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY06_RS09050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY06_RS09055	COG0193	aminoacyl-tRNA hydrolase activity
GPY06_RS09060	COG0012	GTP binding
GPY06_RS09145	COG1943	Transposase
GPY06_RS09150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY06_RS09155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY06_RS09170	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY06_RS09170	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY06_RS09175	COG1706	bacterial-type flagellum-dependent cell motility
GPY06_RS09180	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY06_RS09185	COG4786	Flagellar basal body rod
GPY06_RS09190	COG4787	bacterial-type flagellum-dependent cell motility
GPY06_RS09195	COG1749	Flagellar hook protein flgE
GPY06_RS09200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY06_RS09205	COG1558	bacterial-type flagellum-dependent cell motility
GPY06_RS09210	COG1815	bacterial-type flagellum-dependent cell motility
GPY06_RS09215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY06_RS09220	COG0784	Response regulator, receiver
GPY06_RS09220	COG0835	chemotaxis
GPY06_RS09230	COG2747	anti-sigma28 factor FlgM
GPY06_RS09270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY06_RS09275	COG2608	mercury ion transmembrane transporter activity
GPY06_RS09275	COG2217	Heavy metal translocating P-type atpase
GPY06_RS09305	COG2840	Smr protein MutS2
GPY06_RS09310	COG1187	pseudouridine synthase activity
GPY06_RS09315	COG3706	GGDEF domain
GPY06_RS09320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY06_RS09325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY06_RS09330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY06_RS09335	COG0121	glutamine amidotransferase
GPY06_RS09340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY06_RS09345	COG1960	acyl-CoA dehydrogenase activity
GPY06_RS09355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY06_RS09360	COG0328	RNA-DNA hybrid ribonuclease activity
GPY06_RS09365	COG2226	methyltransferase
GPY06_RS09370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY06_RS09375	COG1388	LysM domain
GPY06_RS09375	COG0741	lytic transglycosylase activity
GPY06_RS09385	COG0347	Belongs to the P(II) protein family
GPY06_RS09395	COG0037	tRNA processing
GPY06_RS09400	COG0825	malonyl-CoA metabolic process
GPY06_RS09405	COG0587	DNA-directed DNA polymerase activity
GPY06_RS09410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY06_RS09415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY06_RS09420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY06_RS09425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY06_RS09430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY06_RS09435	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY06_RS09445	COG0750	zinc metalloprotease
GPY06_RS09450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY06_RS09455	COG0575	Belongs to the CDS family
GPY06_RS09460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY06_RS09465	COG0233	cytoplasmic translational termination
GPY06_RS09470	COG0528	UMP kinase activity
GPY06_RS09475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY06_RS09480	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY06_RS09485	COG0024	Methionine aminopeptidase
GPY06_RS09490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY06_RS09500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY06_RS09505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY06_RS09510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY06_RS09515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPY06_RS09530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY06_RS09530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY06_RS09535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY06_RS09540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY06_RS09545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY06_RS09560	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY06_RS09565	COG2252	PERMEase
GPY06_RS09575	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY06_RS09580	COG0189	ligase activity
GPY06_RS09580	COG4067	protein conserved in archaea
GPY06_RS09585	COG0189	ligase activity
GPY06_RS09595	COG0733	neurotransmitter:sodium symporter activity
GPY06_RS09600	COG4251	negative regulation of phosphorylation
GPY06_RS09600	COG2203	Gaf domain
GPY06_RS09600	COG3706	GGDEF domain
GPY06_RS09600	COG5001	Diguanylate cyclase
GPY06_RS09610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY06_RS09620	COG1477	protein flavinylation
GPY06_RS09625	COG2871	sodium ion transport
GPY06_RS09630	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY06_RS09635	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY06_RS09640	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY06_RS09645	COG1805	sodium ion transport
GPY06_RS09650	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY06_RS09655	COG0271	Belongs to the BolA IbaG family
GPY06_RS09660	COG2813	Specifically methylates the guanine in position
GPY06_RS09670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY06_RS09675	COG2211	Major facilitator Superfamily
GPY06_RS09685	COG1595	DNA-templated transcription, initiation
GPY06_RS09695	COG3248	Nucleoside-binding outer membrane protein
GPY06_RS09700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY06_RS09705	COG0693	protein deglycase activity
GPY06_RS09710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY06_RS09715	COG2166	iron-sulfur cluster assembly
GPY06_RS09720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY06_RS09725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY06_RS09735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY06_RS09735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY06_RS09745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY06_RS09750	COG1074	ATP-dependent DNA helicase activity
GPY06_RS09755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY06_RS09770	COG3141	response to X-ray
GPY06_RS09775	COG2171	N-acyltransferase activity
GPY06_RS09785	COG0456	acetyltransferase
GPY06_RS09805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY06_RS09810	COG1609	Transcriptional regulator
GPY06_RS09815	COG3250	beta-galactosidase activity
GPY06_RS09820	COG2059	Chromate
GPY06_RS09830	COG1022	Amp-dependent synthetase and ligase
GPY06_RS09835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY06_RS09840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY06_RS09850	COG0560	Phosphoserine phosphatase
GPY06_RS09860	COG0813	purine-nucleoside phosphorylase activity
GPY06_RS09865	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY06_RS09870	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY06_RS09875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY06_RS09885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY06_RS09890	COG0084	hydrolase, TatD family'
GPY06_RS09905	COG1115	amino acid carrier protein
GPY06_RS09920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY06_RS09925	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY06_RS09930	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY06_RS09935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY06_RS09940	COG0083	homoserine kinase activity
GPY06_RS09960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY06_RS09970	COG0745	RESPONSE REGULATOR receiver
GPY06_RS09975	COG2198	Histidine kinase
GPY06_RS09975	COG0784	Response regulator, receiver
GPY06_RS09975	COG5002	protein histidine kinase activity
GPY06_RS09980	COG2203	Gaf domain
GPY06_RS09980	COG3706	GGDEF domain
GPY06_RS09980	COG4251	negative regulation of phosphorylation
GPY06_RS09980	COG5001	Diguanylate cyclase
GPY06_RS09985	COG1242	4 iron, 4 sulfur cluster binding
GPY06_RS09990	COG0070	glutamate synthase
GPY06_RS09990	COG0067	glutamate synthase
GPY06_RS09990	COG0069	glutamate synthase activity
GPY06_RS10000	COG0070	glutamate synthase
GPY06_RS10000	COG0069	glutamate synthase activity
GPY06_RS10000	COG0067	glutamate synthase
GPY06_RS10005	COG0493	'glutamate synthase
GPY06_RS10015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY06_RS10025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY06_RS10030	COG2860	membrane
GPY06_RS10035	COG0583	DNA-binding transcription factor activity
GPY06_RS10040	COG0730	response to heat
GPY06_RS10045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY06_RS10050	COG0505	Belongs to the CarA family
GPY06_RS10055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY06_RS10060	COG0494	nUDIX hydrolase
GPY06_RS10065	COG0653	protein targeting
GPY06_RS10075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY06_RS10080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY06_RS10085	COG0849	cell division
GPY06_RS10090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY06_RS10095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY06_RS10100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY06_RS10105	COG0772	Belongs to the SEDS family
GPY06_RS10110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY06_RS10115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY06_RS10120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY06_RS10125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY06_RS10130	COG0768	penicillin binding
GPY06_RS10135	COG3116	cell division
GPY06_RS10140	COG0275	rRNA processing
GPY06_RS10150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY06_RS10155	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY06_RS10160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY06_RS10165	COG2186	Transcriptional regulator
GPY06_RS10170	COG0737	Belongs to the 5'-nucleotidase family
GPY06_RS10175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY06_RS10180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY06_RS10185	COG4974	Belongs to the 'phage' integrase family
GPY06_RS10190	COG0716	FMN binding
GPY06_RS10200	COG0157	Belongs to the NadC ModD family
GPY06_RS10210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY06_RS10215	COG1459	type II secretion system
GPY06_RS10225	COG0237	dephospho-CoA kinase activity
GPY06_RS10230	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY06_RS10235	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY06_RS10240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY06_RS10245	COG0187	DNA topoisomerase II activity
GPY06_RS10250	COG3150	esterase
GPY06_RS10260	COG3151	Protein conserved in bacteria
GPY06_RS10265	COG0494	nUDIX hydrolase
GPY06_RS10270	COG1538	Outer membrane efflux protein
GPY06_RS10275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY06_RS10275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY06_RS10280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY06_RS10290	COG3025	triphosphatase activity
GPY06_RS10295	COG1392	Phosphate transport regulator
GPY06_RS10300	COG0306	phosphate transporter
GPY06_RS10305	COG4991	sh3 domain protein
GPY06_RS10320	COG0617	tRNA 3'-terminal CCA addition
GPY06_RS10325	COG0148	phosphopyruvate hydratase activity
GPY06_RS10330	COG0504	CTP synthase activity
GPY06_RS10335	COG3956	TIGRFAM MazG family protein
GPY06_RS10340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY06_RS10345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY06_RS10350	COG3850	Histidine kinase
GPY06_RS10350	COG4999	Histidine kinase
GPY06_RS10350	COG3437	response regulator, receiver
GPY06_RS10350	COG2205	protein histidine kinase activity
GPY06_RS10355	COG5001	Diguanylate cyclase
GPY06_RS10370	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY06_RS10375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY06_RS10380	COG1381	Involved in DNA repair and RecF pathway recombination
GPY06_RS10385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY06_RS10390	COG0571	ribonuclease III activity
GPY06_RS10395	COG0681	Belongs to the peptidase S26 family
GPY06_RS10400	COG0481	GTPase activity
GPY06_RS10405	COG3086	response to oxidative stress
GPY06_RS10420	COG1595	DNA-templated transcription, initiation
GPY06_RS10425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY06_RS10435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY06_RS10440	COG0354	folic acid binding
GPY06_RS10450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY06_RS10455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY06_RS10460	COG3079	Belongs to the UPF0149 family
GPY06_RS10465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY06_RS10475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY06_RS10480	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY06_RS10485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY06_RS10495	COG0028	Belongs to the TPP enzyme family
GPY06_RS10500	COG1022	Amp-dependent synthetase and ligase
GPY06_RS10505	COG0583	DNA-binding transcription factor activity
GPY06_RS10525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY06_RS10530	COG0473	3-isopropylmalate dehydrogenase activity
GPY06_RS10535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY06_RS10540	COG0066	3-isopropylmalate dehydratase activity
GPY06_RS10590	COG3437	response regulator, receiver
GPY06_RS10605	COG0795	lipopolysaccharide-transporting ATPase activity
GPY06_RS10610	COG0795	lipopolysaccharide-transporting ATPase activity
GPY06_RS10615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY06_RS10620	COG2927	DNA polymerase III (CHI subunit)
GPY06_RS10625	COG0525	valine-tRNA ligase activity
GPY06_RS10635	COG4269	membrane
GPY06_RS10640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY06_RS10645	COG0564	pseudouridine synthase activity
GPY06_RS10650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY06_RS10655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY06_RS10660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY06_RS10665	COG0540	Belongs to the ATCase OTCase family
GPY06_RS10670	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY06_RS10675	COG0251	oxidation-reduction process
GPY06_RS10680	COG0204	Acyl-transferase
GPY06_RS10685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY06_RS10690	COG5007	Belongs to the BolA IbaG family
GPY06_RS10700	COG2854	intermembrane phospholipid transfer
GPY06_RS10705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY06_RS10710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY06_RS10715	COG1127	ABC transporter
GPY06_RS10725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY06_RS10725	COG0517	IMP dehydrogenase activity
GPY06_RS10740	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY06_RS10745	COG1137	ATPase activity
GPY06_RS10755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY06_RS10760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS10770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS10775	COG2239	Acts as a magnesium transporter
GPY06_RS10780	COG0312	modulator of DNA gyrase
GPY06_RS10785	COG3028	Belongs to the UPF0307 family
GPY06_RS10790	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY06_RS10795	COG1178	ABC-type Fe3 transport system permease component
GPY06_RS10800	COG4143	(ABC) transporter
GPY06_RS10805	COG0163	prenyltransferase activity
GPY06_RS10810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY06_RS10815	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY06_RS10820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY06_RS10825	COG2105	PFAM AIG2 family protein
GPY06_RS10835	COG0729	surface antigen
GPY06_RS10840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY06_RS10845	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY06_RS10860	COG0577	efflux transmembrane transporter activity
GPY06_RS10860	COG1136	(ABC) transporter
GPY06_RS10880	COG0529	Catalyzes the synthesis of activated sulfate
GPY06_RS10885	COG2895	sulfate adenylyltransferase (ATP) activity
GPY06_RS10890	COG0175	sulfate reduction
GPY06_RS10895	COG1648	precorrin-2 dehydrogenase activity
GPY06_RS10895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY06_RS10900	COG0737	Belongs to the 5'-nucleotidase family
GPY06_RS10910	COG0513	Belongs to the DEAD box helicase family
GPY06_RS10915	COG2153	protein acetylation
GPY06_RS10920	COG0697	spore germination
GPY06_RS10925	COG3266	domain, Protein
GPY06_RS10925	COG3061	Opacity-associated protein A
GPY06_RS10930	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY06_RS10940	COG0203	ribosomal protein L17
GPY06_RS10945	COG0202	RNA polymerase activity
GPY06_RS10950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY06_RS10955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY06_RS10960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY06_RS10970	COG0201	protein transport
GPY06_RS10975	COG0200	Binds to the 23S rRNA
GPY06_RS10980	COG1841	ribosomal large subunit assembly
GPY06_RS10985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPY06_RS10990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY06_RS10995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY06_RS11000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY06_RS11005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY06_RS11010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY06_RS11015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY06_RS11020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY06_RS11030	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY06_RS11035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPY06_RS11040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY06_RS11045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY06_RS11050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY06_RS11055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY06_RS11060	COG0089	rRNA binding
GPY06_RS11065	COG0088	Forms part of the polypeptide exit tunnel
GPY06_RS11070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY06_RS11075	COG0051	transcription antitermination factor activity, RNA binding
GPY06_RS11080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY06_RS11085	COG0557	exoribonuclease II activity
GPY06_RS11095	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY06_RS11100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY06_RS11105	COG1446	asparaginase
GPY06_RS11110	COG1047	Peptidyl-prolyl cis-trans
GPY06_RS11125	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY06_RS11130	COG0488	(ABC) transporter
GPY06_RS11140	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY06_RS11150	COG3954	Phosphoribulokinase
GPY06_RS11155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY06_RS11175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY06_RS11185	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY06_RS11190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY06_RS11205	COG0180	Tryptophanyl-tRNA synthetase
GPY06_RS11210	COG0546	phosphoglycolate phosphatase activity
GPY06_RS11215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY06_RS11220	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY06_RS11230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY06_RS11235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY06_RS11265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY06_RS11275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY06_RS11275	COG0678	peroxiredoxin activity
GPY06_RS11280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY06_RS11290	COG0165	Argininosuccinate lyase
GPY06_RS11295	COG0137	argininosuccinate synthase activity
GPY06_RS11300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY06_RS11305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY06_RS11310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY06_RS11315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY06_RS11325	COG1045	serine acetyltransferase
GPY06_RS11330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY06_RS11335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY06_RS11340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY06_RS11345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY06_RS11350	COG1053	succinate dehydrogenase
GPY06_RS11355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY06_RS11360	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY06_RS11365	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY06_RS11370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY06_RS11375	COG1509	lysine 2,3-aminomutase activity
GPY06_RS11385	COG0459	protein refolding
GPY06_RS11390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY06_RS11415	COG0149	triose-phosphate isomerase activity
GPY06_RS11425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY06_RS11430	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY06_RS11435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY06_RS11440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY06_RS11445	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY06_RS11450	COG1609	Transcriptional regulator
GPY06_RS11455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY06_RS11460	COG0254	rRNA binding
GPY06_RS11465	COG0281	malic enzyme
GPY06_RS11470	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPY06_RS11475	COG0626	cystathionine gamma-synthase activity
GPY06_RS11480	COG0460	homoserine dehydrogenase
GPY06_RS11480	COG0527	aspartate kinase activity
GPY06_RS11485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY06_RS11490	COG3074	FtsZ-dependent cytokinesis
GPY06_RS11495	COG1494	fructose-1,6-bisphosphatase
GPY06_RS11500	COG0205	6-phosphofructokinase activity
GPY06_RS11515	COG0745	RESPONSE REGULATOR receiver
GPY06_RS11520	COG2205	protein histidine kinase activity
GPY06_RS11525	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY06_RS11530	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY06_RS11535	COG3706	GGDEF domain
GPY06_RS11540	COG1027	Aspartate ammonia-lyase
GPY06_RS11545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY06_RS11550	COG4232	protein-disulfide reductase activity
GPY06_RS11560	COG3263	regulation of cellular component size
GPY06_RS11570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY06_RS11575	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY06_RS11580	COG0194	GDP metabolic process
GPY06_RS11585	COG1758	RNA polymerase activity
GPY06_RS11590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY06_RS11595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY06_RS11600	COG2233	PERMEase
GPY06_RS11610	COG0745	RESPONSE REGULATOR receiver
GPY06_RS11615	COG2199	diguanylate cyclase activity
GPY06_RS11620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY06_RS11625	COG2183	response to ionizing radiation
GPY06_RS11635	COG0596	Alpha beta hydrolase
GPY06_RS11640	COG1040	competence protein
GPY06_RS11645	COG0316	Belongs to the HesB IscA family
GPY06_RS11645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY06_RS11650	COG0494	nUDIX hydrolase
GPY06_RS11655	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY06_RS11665	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY06_RS11670	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY06_RS11675	COG3156	type II secretion system protein K
GPY06_RS11680	COG4795	General secretion pathway protein
GPY06_RS11685	COG2165	general secretion pathway protein
GPY06_RS11690	COG2165	general secretion pathway protein
GPY06_RS11695	COG2165	general secretion pathway protein
GPY06_RS11700	COG1459	type II secretion system
GPY06_RS11705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY06_RS11715	COG3031	protein transport across the cell outer membrane
GPY06_RS11720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY06_RS11725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY06_RS11730	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY06_RS11740	COG0456	acetyltransferase
GPY06_RS11745	COG1490	D-aminoacyl-tRNA deacylase activity
GPY06_RS11755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY06_RS11765	COG0174	glutamine synthetase
GPY06_RS11775	COG3852	Histidine kinase
GPY06_RS11785	COG3300	MHYT domain
GPY06_RS11785	COG5001	Diguanylate cyclase
GPY06_RS11790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY06_RS11860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY06_RS11875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY06_RS11890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY06_RS11895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY06_RS11900	COG2177	Part of the ABC transporter FtsEX involved in
GPY06_RS11905	COG2884	Cell division ATP-binding protein ftsE
GPY06_RS11910	COG0552	protein localization to endoplasmic reticulum
GPY06_RS11915	COG0742	ribosomal rna small subunit methyltransferase
GPY06_RS11945	COG0783	Belongs to the Dps family
GPY06_RS11950	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY06_RS11955	COG1280	lysine exporter protein (LysE YggA)
GPY06_RS11960	COG2267	carboxylic ester hydrolase activity
GPY06_RS11965	COG0561	phosphatase activity
GPY06_RS11980	COG3287	FIST C domain
GPY06_RS11980	COG2200	EAL domain
GPY06_RS11980	COG2199	diguanylate cyclase activity
GPY06_RS11985	COG1011	Hydrolase
GPY06_RS11990	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY06_RS12000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY06_RS12005	COG0019	diaminopimelate decarboxylase activity
GPY06_RS12015	COG1965	Belongs to the frataxin family
GPY06_RS12020	COG3072	Adenylate cyclase
GPY06_RS12025	COG0181	hydroxymethylbilane synthase activity
GPY06_RS12030	COG1587	Uroporphyrinogen-III synthase
GPY06_RS12035	COG2959	enzyme of heme biosynthesis
GPY06_RS12040	COG3071	HemY protein
GPY06_RS12045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY06_RS12055	COG3078	GTPase activator activity
GPY06_RS12070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY06_RS12075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY06_RS12075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY06_RS12090	COG0084	hydrolase, TatD family'
GPY06_RS12095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY06_RS12105	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY06_RS12115	COG3161	chorismate lyase activity
GPY06_RS12120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY06_RS12125	COG2937	Belongs to the GPAT DAPAT family
GPY06_RS12130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY06_RS12140	COG0534	Mate efflux family protein
GPY06_RS12145	COG1858	cytochrome C peroxidase
GPY06_RS12150	COG0805	protein transport
GPY06_RS12155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY06_RS12160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY06_RS12165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY06_RS12175	COG2226	methyltransferase
GPY06_RS12180	COG1322	Protein conserved in bacteria
GPY06_RS12190	COG0840	transmembrane signaling receptor activity
GPY06_RS12195	COG2081	HI0933 family
GPY06_RS12205	COG1528	Iron-storage protein
GPY06_RS12215	COG0589	response to stress
GPY06_RS12220	COG0697	spore germination
GPY06_RS12230	COG0742	ribosomal rna small subunit methyltransferase
GPY06_RS12235	COG5002	protein histidine kinase activity
GPY06_RS12235	COG5001	Diguanylate cyclase
GPY06_RS12240	COG1522	sequence-specific DNA binding
GPY06_RS12260	COG0006	proline dipeptidase activity
GPY06_RS12260	COG0006	proline dipeptidase activity
GPY06_RS12265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY06_RS12270	COG2022	thiamine diphosphate biosynthetic process
GPY06_RS12275	COG2104	thiamine diphosphate biosynthetic process
GPY06_RS12280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY06_RS12290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY06_RS12295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY06_RS12335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY06_RS12345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY06_RS12355	COG0009	L-threonylcarbamoyladenylate synthase
GPY06_RS12360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY06_RS12365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY06_RS12370	COG0551	DNA topoisomerase type I activity
GPY06_RS12375	COG2922	Belongs to the Smg family
GPY06_RS12380	COG0758	DNA mediated transformation
GPY06_RS12385	COG1652	LysM domain
GPY06_RS12390	COG0242	peptide deformylase activity
GPY06_RS12400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY06_RS12400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY06_RS12405	COG0569	domain protein
GPY06_RS12410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY06_RS12420	COG1272	protein, Hemolysin III
GPY06_RS12425	COG4326	sporulation control protein
GPY06_RS12435	COG3084	Protein conserved in bacteria
GPY06_RS12445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY06_RS12450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY06_RS12455	COG0204	Acyl-transferase
GPY06_RS12460	COG0606	chelatase, subunit chli
GPY06_RS12475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY06_RS12480	COG0129	dihydroxy-acid dehydratase activity
GPY06_RS12490	COG0604	alcohol dehydrogenase
GPY06_RS12500	COG0425	Belongs to the sulfur carrier protein TusA family
GPY06_RS12510	COG2119	membrane
GPY06_RS12515	COG0752	glycyl-tRNA synthetase alpha subunit
GPY06_RS12520	COG0751	glycine-tRNA ligase activity
GPY06_RS12525	COG3977	Valine--pyruvate aminotransferase
GPY06_RS12530	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY06_RS12545	COG0187	DNA topoisomerase II activity
GPY06_RS12550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY06_RS12555	COG0592	DNA-directed DNA polymerase activity
GPY06_RS12560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY06_RS12575	COG1126	abc transporter atp-binding protein
GPY06_RS12580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY06_RS12585	COG0594	ribonuclease P activity
GPY06_RS12590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY06_RS12595	COG0706	membrane insertase activity
GPY06_RS12600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY06_RS12605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY06_RS12610	COG0445	tRNA wobble uridine modification
GPY06_RS12615	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY06_RS12620	COG1192	Involved in chromosome partitioning
GPY06_RS12625	COG1475	DNA binding
GPY06_RS12630	COG3312	ion transport
GPY06_RS12635	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY06_RS12645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY06_RS12650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY06_RS12655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY06_RS12660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY06_RS12665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY06_RS12670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY06_RS12680	COG2814	Major facilitator Superfamily
GPY06_RS12685	COG0583	DNA-binding transcription factor activity
GPY06_RS12690	COG0183	Belongs to the thiolase family
GPY06_RS12695	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY06_RS12695	COG1024	Enoyl-CoA hydratase
GPY06_RS12700	COG1739	Uncharacterized protein family UPF0029
GPY06_RS12705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY06_RS12710	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPY06_RS12780	COG0583	DNA-binding transcription factor activity
GPY06_RS12785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY06_RS12790	COG2960	long-chain fatty acid transporting porin activity
GPY06_RS12795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY06_RS12800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY06_RS12805	COG1309	transcriptional regulator
GPY06_RS12850	COG0747	negative chemotaxis
GPY06_RS12870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY06_RS12875	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY06_RS12885	COG0210	DNA helicase
GPY06_RS12890	COG1280	lysine exporter protein (LysE YggA)
GPY06_RS12905	COG2962	Rard protein
GPY06_RS12910	COG0514	ATP-dependent DNA helicase (RecQ)
GPY06_RS12925	COG1132	(ABC) transporter
GPY06_RS12930	COG4774	siderophore transport
GPY06_RS12935	COG1120	ATPase activity
GPY06_RS12960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY06_RS12965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY06_RS12965	COG1263	PTS System
GPY06_RS12975	COG1561	YicC-like family, N-terminal region
GPY06_RS12980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY06_RS12985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY06_RS12990	COG1560	Kdo2-lipid A biosynthetic process
GPY06_RS12995	COG1560	Kdo2-lipid A biosynthetic process
GPY06_RS13000	COG1309	transcriptional regulator
GPY06_RS13005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY06_RS13020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY06_RS13025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY06_RS13035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY06_RS13040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY06_RS13045	COG0859	PFAM glycosyl transferase family 9
GPY06_RS13050	COG0463	Glycosyl transferase, family 2
GPY06_RS13055	COG0859	PFAM glycosyl transferase family 9
GPY06_RS13060	COG3642	lipopolysaccharide core region biosynthetic process
GPY06_RS13085	COG1519	Transferase
GPY06_RS13130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY06_RS13140	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY06_RS13145	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY06_RS13185	COG0673	inositol 2-dehydrogenase activity
GPY06_RS13195	COG0297	glycogen (starch) synthase activity
GPY06_RS13205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY06_RS13215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY06_RS13220	COG0668	transmembrane transport
GPY06_RS13225	COG1573	uracil-dna glycosylase
GPY06_RS13230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY06_RS13235	COG3068	Protein conserved in bacteria
GPY06_RS13240	COG1253	flavin adenine dinucleotide binding
GPY06_RS13245	COG0776	regulation of translation
GPY06_RS13255	COG0151	Belongs to the GarS family
GPY06_RS13260	COG0138	bifunctional purine biosynthesis protein purh
GPY06_RS13270	COG0789	Transcriptional regulator
GPY06_RS13275	COG3710	Transcriptional regulator
GPY06_RS13285	COG0531	amino acid
GPY06_RS13290	COG1982	Orn Lys Arg decarboxylase major
GPY06_RS13295	COG0840	transmembrane signaling receptor activity
GPY06_RS13300	COG0800	Aldolase
GPY06_RS13305	COG2610	gluconate transmembrane transporter activity
GPY06_RS13310	COG3265	gluconokinase activity
GPY06_RS13315	COG0129	dihydroxy-acid dehydratase activity
GPY06_RS13320	COG1609	Transcriptional regulator
GPY06_RS13325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY06_RS13330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY06_RS13335	COG2264	protein methyltransferase activity
GPY06_RS13340	COG0439	Biotin carboxylase
GPY06_RS13345	COG0511	ligase activity, forming carbon-carbon bonds
GPY06_RS13350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY06_RS13355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY06_RS13370	COG2814	Major facilitator Superfamily
GPY06_RS13375	COG2205	protein histidine kinase activity
GPY06_RS13375	COG0784	Response regulator, receiver
GPY06_RS13380	COG0248	Ppx GppA phosphatase
GPY06_RS13385	COG0513	Belongs to the DEAD box helicase family
GPY06_RS13390	COG3118	belongs to the thioredoxin family
GPY06_RS13395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY06_RS13405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY06_RS13445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY06_RS13455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY06_RS13465	COG1072	(Pantothenic acid kinase))
GPY06_RS13490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY06_RS13495	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY06_RS13500	COG0250	Participates in transcription elongation, termination and antitermination
GPY06_RS13505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY06_RS13510	COG0081	regulation of translation
GPY06_RS13515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY06_RS13520	COG0222	ribosome binding
GPY06_RS13525	COG0085	RNA polymerase activity
GPY06_RS13530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY06_RS13535	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY06_RS13540	COG2816	NAD+ diphosphatase activity
GPY06_RS13545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY06_RS13560	COG4942	peptidase
GPY06_RS13565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY06_RS13575	COG0471	metal ion transport
GPY06_RS13580	COG0688	phosphatidylethanolamine metabolic process
GPY06_RS13585	COG1162	GTPase activity
GPY06_RS13590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY06_RS13640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY06_RS13645	COG0802	atpase or kinase
GPY06_RS13655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY06_RS13660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY06_RS13665	COG1923	regulation of RNA biosynthetic process
GPY06_RS13670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY06_RS13675	COG0330	HflC and HflK could
GPY06_RS13680	COG0330	HflC and HflK could
GPY06_RS13685	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY06_RS13690	COG2900	Belongs to the SlyX family
GPY06_RS13700	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY06_RS13705	COG2964	Protein conserved in bacteria
GPY06_RS13710	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY06_RS13715	COG2923	Belongs to the DsrF TusC family
GPY06_RS13725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPY06_RS13730	COG0049	tRNA binding
GPY06_RS13735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY06_RS13740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY06_RS13750	COG2906	2 iron, 2 sulfur cluster binding
GPY06_RS13760	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY06_RS13765	COG2965	DNA replication, synthesis of RNA primer
GPY06_RS13770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPY06_RS13775	COG0359	binds to the 23S rRNA
GPY06_RS13785	COG0305	Participates in initiation and elongation during chromosome replication
GPY06_RS13790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY06_RS13795	COG0432	Pfam Uncharacterised protein family UPF0047
GPY06_RS13800	COG0166	Belongs to the GPI family
GPY06_RS13815	COG0735	belongs to the Fur family
GPY06_RS13820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY06_RS13845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY06_RS13850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY06_RS13855	COG0175	sulfate reduction
GPY06_RS13930	COG0646	methionine synthase
GPY06_RS13930	COG1410	methionine synthase
GPY06_RS13935	COG0527	aspartate kinase activity
GPY06_RS13940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY06_RS13950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY06_RS13970	COG2200	EAL domain
GPY06_RS13970	COG2199	diguanylate cyclase activity
GPY06_RS13990	COG1450	Type ii and iii secretion system protein
GPY06_RS13995	COG3267	Type II secretory pathway component ExeA
GPY06_RS13995	COG3409	Peptidoglycan-binding domain 1 protein
GPY06_RS14005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY06_RS14010	COG1459	type II secretion system
GPY06_RS14055	COG1077	Cell shape determining protein MreB Mrl
GPY06_RS14060	COG1792	Involved in formation and maintenance of cell shape
GPY06_RS14065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY06_RS14070	COG0424	maF-like protein
GPY06_RS14075	COG1530	ribonuclease E activity
GPY06_RS14080	COG3164	Protein of unknown function
GPY06_RS14085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY06_RS14090	COG0312	modulator of DNA gyrase
GPY06_RS14095	COG1151	hydroxylamine reductase activity
GPY06_RS14100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY06_RS14105	COG2235	arginine
GPY06_RS14125	COG0589	response to stress
GPY06_RS14140	COG1438	arginine binding
GPY06_RS14145	COG0039	L-malate dehydrogenase activity
GPY06_RS14150	COG0531	amino acid
GPY06_RS14155	COG0142	geranyltranstransferase activity
GPY06_RS14160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY06_RS14165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY06_RS14170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY06_RS14175	COG2966	Psort location CytoplasmicMembrane, score
GPY06_RS14180	COG3610	response to peptide
GPY06_RS14190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY06_RS14195	COG2967	ApaG domain
GPY06_RS14200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY06_RS14205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY06_RS14210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY06_RS14215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY06_RS14220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY06_RS14275	COG0741	lytic transglycosylase activity
GPY06_RS14280	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY06_RS14285	COG1194	a g-specific adenine glycosylase
GPY06_RS14290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY06_RS14295	COG2066	Belongs to the glutaminase family
GPY06_RS14300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY06_RS14305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY06_RS14320	COG0762	integral membrane protein
GPY06_RS14325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY06_RS14330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY06_RS14350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY06_RS14355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY06_RS14360	COG1678	Uncharacterized ACR, COG1678
GPY06_RS14365	COG0189	ligase activity
GPY06_RS14370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY06_RS14375	COG2356	endonuclease I
GPY06_RS14380	COG3091	SprT-like family
GPY06_RS14385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY06_RS14390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY06_RS14395	COG0583	DNA-binding transcription factor activity
GPY06_RS14400	COG4771	TonB-dependent receptor
GPY06_RS14405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY06_RS14410	COG0126	phosphoglycerate kinase activity
GPY06_RS14415	COG0191	fructose-bisphosphate aldolase activity
GPY06_RS14420	COG0668	transmembrane transport
GPY06_RS14425	COG1279	arginine transmembrane transporter activity
GPY06_RS14430	COG0583	DNA-binding transcription factor activity
GPY06_RS14440	COG0469	pyruvate kinase activity
GPY06_RS14445	COG1349	DNA-binding transcription factor activity
GPY06_RS14450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY06_RS14455	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY06_RS14490	COG0328	RNA-DNA hybrid ribonuclease activity
GPY06_RS14525	COG0582	viral genome integration into host DNA
GPY06_RS14535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY06_RS14540	COG0358	DNA primase activity
GPY06_RS14545	COG1610	YqeY-like protein
GPY06_RS14550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY06_RS14555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY06_RS14560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPY06_RS14565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY06_RS14570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY06_RS14575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY06_RS14580	COG1968	undecaprenyl-diphosphatase activity
GPY06_RS14585	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY06_RS14590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY06_RS14595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY06_RS14600	COG0585	pseudouridine synthase activity
GPY06_RS14605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY06_RS14610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY06_RS14615	COG4942	peptidase
GPY06_RS14615	COG1388	LysM domain
GPY06_RS14620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY06_RS14625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY06_RS14635	COG4150	thiosulfate binding
GPY06_RS14645	COG4208	sulfate ABC transporter
GPY06_RS14650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPY06_RS14660	COG1546	Belongs to the CinA family
GPY06_RS14665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY06_RS14670	COG2137	regulation of response to DNA damage stimulus
GPY06_RS14675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY06_RS14680	COG0527	aspartate kinase activity
GPY06_RS14685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPY06_RS14725	COG3630	sodium ion export across plasma membrane
GPY06_RS14730	COG0511	ligase activity, forming carbon-carbon bonds
GPY06_RS14730	COG5016	pyruvate
GPY06_RS14735	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY06_RS14745	COG1238	metal cluster binding
GPY06_RS14750	COG0612	Peptidase, M16
GPY06_RS14755	COG2918	glutathione biosynthetic process
GPY06_RS14760	COG1854	S-ribosylhomocysteine lyase activity
GPY06_RS14765	COG4536	flavin adenine dinucleotide binding
GPY06_RS14770	COG4137	Cytochrome C assembly protein
GPY06_RS14775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY06_RS14780	COG0228	four-way junction DNA binding
GPY06_RS14785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY06_RS14790	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY06_RS14795	COG0335	large ribosomal subunit rRNA binding
GPY06_RS14800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY06_RS14805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY06_RS14815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY06_RS14820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY06_RS14825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY06_RS14830	COG0723	plastoquinol--plastocyanin reductase activity
GPY06_RS14835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY06_RS14840	COG2857	Cytochrome c1
GPY06_RS14845	COG0625	glutathione transferase activity
GPY06_RS14850	COG2969	positive regulation of protein catabolic process
GPY06_RS14855	COG2823	Periplasmic or secreted lipoprotein
GPY06_RS14860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY06_RS14865	COG0792	nuclease activity
GPY06_RS14870	COG3107	peptidoglycan biosynthetic process
GPY06_RS14875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY06_RS14890	COG0288	reversible hydration of carbon dioxide
GPY06_RS14895	COG0659	secondary active sulfate transmembrane transporter activity
GPY06_RS14900	COG1131	(ABC) transporter
GPY06_RS14905	COG0842	Transport permease protein
GPY06_RS14910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY06_RS14915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY06_RS14920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY06_RS14930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY06_RS14935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY06_RS14940	COG1489	DNA binding
GPY06_RS14950	COG1643	Atp-dependent helicase
GPY06_RS14955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY06_RS14960	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY06_RS14970	COG3112	Uncharacterised protein family (UPF0231)
GPY06_RS14975	COG0347	Belongs to the P(II) protein family
GPY06_RS14980	COG0004	ammonium transporteR
GPY06_RS14985	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY06_RS14995	COG3842	ATPase activity
GPY06_RS15015	COG2971	BadF BadG BcrA BcrD
GPY06_RS15025	COG4608	Belongs to the ABC transporter superfamily
GPY06_RS15030	COG0444	Belongs to the ABC transporter superfamily
GPY06_RS15035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY06_RS15045	COG0747	negative chemotaxis
GPY06_RS15055	COG2813	Specifically methylates the guanine in position
GPY06_RS15060	COG0628	permease
GPY06_RS15065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY06_RS15070	COG0316	Belongs to the HesB IscA family
GPY06_RS15080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY06_RS15085	COG0739	heme binding
GPY06_RS15090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY06_RS15095	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY06_RS15105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY06_RS15110	COG1534	Rna-binding protein
GPY06_RS15115	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY06_RS15120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY06_RS15125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY06_RS15130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY06_RS15135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY06_RS15150	COG0779	Required for maturation of 30S ribosomal subunits
GPY06_RS15155	COG0195	Participates in both transcription termination and antitermination
GPY06_RS15160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY06_RS15165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY06_RS15170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY06_RS15175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY06_RS15180	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY06_RS15220	COG3153	acetyltransferase
GPY06_RS15240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY06_RS15245	COG0513	Belongs to the DEAD box helicase family
GPY06_RS15250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY06_RS15265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY06_RS15270	COG2204	response regulator
GPY06_RS15280	COG0667	Aldo Keto reductase
GPY06_RS15285	COG3066	DNA modification
GPY06_RS15290	COG0494	nUDIX hydrolase
GPY06_RS15295	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPY06_RS15300	COG0730	response to heat
GPY06_RS15305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY06_RS15310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY06_RS15315	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY06_RS15320	COG0583	DNA-binding transcription factor activity
GPY06_RS15325	COG0640	Transcriptional regulator
GPY06_RS15330	COG0268	Binds directly to 16S ribosomal RNA
GPY06_RS15335	COG0728	peptidoglycan biosynthetic process
GPY06_RS15340	COG0196	riboflavin kinase activity
GPY06_RS15345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY06_RS15350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY06_RS15355	COG1047	Peptidyl-prolyl cis-trans
GPY06_RS15360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY06_RS15365	COG1966	Carbon starvation protein
GPY06_RS15380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY06_RS15385	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY06_RS15390	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY06_RS15395	COG3279	Response regulator of the LytR AlgR family
GPY06_RS15400	COG3275	phosphorelay sensor kinase activity
GPY06_RS15405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY06_RS15410	COG0287	Prephenate dehydrogenase
GPY06_RS15410	COG1605	Chorismate mutase
GPY06_RS15420	COG0488	(ABC) transporter
GPY06_RS15430	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY06_RS15435	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY06_RS15440	COG5001	Diguanylate cyclase
GPY06_RS15445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY06_RS15450	COG0077	Prephenate dehydratase
GPY06_RS15450	COG1605	Chorismate mutase
GPY06_RS15455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY06_RS15460	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY06_RS15465	COG0564	pseudouridine synthase activity
GPY06_RS15475	COG0542	response to heat
GPY06_RS15520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY06_RS15530	COG2974	May be involved in recombination
GPY06_RS15535	COG0745	RESPONSE REGULATOR receiver
GPY06_RS15540	COG5002	protein histidine kinase activity
GPY06_RS15550	COG0248	Ppx GppA phosphatase
GPY06_RS15555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY06_RS15565	COG0581	inorganic phosphate transmembrane transporter activity
GPY06_RS15570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY06_RS15585	COG3142	Participates in the control of copper homeostasis
GPY06_RS15590	COG0450	alkyl hydroperoxide reductase
GPY06_RS15595	COG0583	DNA-binding transcription factor activity
GPY06_RS15600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY06_RS15610	COG0517	IMP dehydrogenase activity
GPY06_RS15615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY06_RS15625	COG0343	queuine tRNA-ribosyltransferase activity
GPY06_RS15630	COG1862	Preprotein translocase
GPY06_RS15635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY06_RS15640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY06_RS15645	COG0483	inositol monophosphate 1-phosphatase activity
GPY06_RS15650	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY06_RS15655	COG1959	2 iron, 2 sulfur cluster binding
GPY06_RS15665	COG0822	iron-sulfur transferase activity
GPY06_RS15675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY06_RS15685	COG0633	Ferredoxin
GPY06_RS15690	COG2975	iron-sulfur cluster assembly
GPY06_RS15695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY06_RS15700	COG0105	UTP biosynthetic process
GPY06_RS15705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY06_RS15710	COG1426	Protein conserved in bacteria
GPY06_RS15715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY06_RS15720	COG0124	histidyl-tRNA synthetase
GPY06_RS15725	COG2976	Protein conserved in bacteria
GPY06_RS15730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY06_RS15735	COG1160	GTP binding
GPY06_RS15740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY06_RS15750	COG1570	exodeoxyribonuclease VII activity
GPY06_RS15755	COG0516	GMP reductase activity
GPY06_RS15755	COG0517	IMP dehydrogenase activity
GPY06_RS15760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY06_RS15760	COG0519	Catalyzes the synthesis of GMP from XMP
GPY06_RS15770	COG1584	GPR1 FUN34 yaaH family protein
GPY06_RS15775	COG0583	DNA-binding transcription factor activity
GPY06_RS15780	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY06_RS15785	COG1115	amino acid carrier protein
GPY06_RS15790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY06_RS15795	COG0583	DNA-binding transcription factor activity
GPY06_RS15805	COG2200	EAL domain
GPY06_RS15815	COG4565	transcriptional regulatory protein
GPY06_RS15825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY06_RS15830	COG0511	ligase activity, forming carbon-carbon bonds
GPY06_RS15830	COG5016	pyruvate
GPY06_RS15835	COG3630	sodium ion export across plasma membrane
GPY06_RS15845	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPY06_RS15850	COG3052	prosthetic group binding
GPY06_RS15855	COG2301	Belongs to the HpcH HpaI aldolase family
GPY06_RS15860	COG3051	citrate lyase alpha subunit
GPY06_RS15865	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPY06_RS15870	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPY06_RS15880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY06_RS15885	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY06_RS15890	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY06_RS15905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY06_RS15910	COG0732	type I restriction modification DNA specificity domain
GPY06_RS15915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY06_RS15960	COG0328	RNA-DNA hybrid ribonuclease activity
GPY06_RS15975	COG2003	Belongs to the UPF0758 family
GPY06_RS16020	COG0582	viral genome integration into host DNA
GPY06_RS16030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY06_RS16035	COG2867	negative regulation of translational initiation
GPY06_RS16040	COG2914	Belongs to the UPF0125 (RnfH) family
GPY06_RS16045	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY06_RS16050	COG0497	DNA recombination
GPY06_RS16055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY06_RS16060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY06_RS16065	COG0443	Heat shock 70 kDa protein
GPY06_RS16070	COG0484	heat shock protein binding
GPY06_RS16100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY06_RS16105	COG0590	tRNA wobble adenosine to inosine editing
GPY06_RS16110	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY06_RS16125	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY06_RS16125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY06_RS16145	COG0442	prolyl-tRNA aminoacylation
GPY06_RS16150	COG1720	tRNA m6t6A37 methyltransferase activity
GPY06_RS16155	COG0254	rRNA binding
GPY06_RS16160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY06_RS16165	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY06_RS16170	COG1671	Belongs to the UPF0178 family
GPY06_RS16200	COG0564	pseudouridine synthase activity
GPY06_RS16205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY06_RS16210	COG0142	geranyltranstransferase activity
GPY06_RS16215	COG1722	exodeoxyribonuclease VII activity
GPY06_RS16220	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY06_RS16230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY06_RS16230	COG0301	tRNA thio-modification
GPY06_RS16235	COG0583	DNA-binding transcription factor activity
GPY06_RS16240	COG2363	Small membrane protein
GPY06_RS16245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY06_RS16250	COG1611	Belongs to the LOG family
GPY06_RS16255	COG3706	GGDEF domain
GPY06_RS16265	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY06_RS16265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY06_RS16275	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY06_RS16280	COG1464	Belongs to the NlpA lipoprotein family
GPY06_RS16285	COG2011	ABC-type metal ion transport system permease component
GPY06_RS16290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY06_RS16295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY06_RS16300	COG1609	Transcriptional regulator
GPY06_RS16305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY06_RS16305	COG1263	PTS System
GPY06_RS16310	COG0366	Alpha amylase catalytic
GPY06_RS16330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY06_RS16335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY06_RS16340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY06_RS16345	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY06_RS16350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY06_RS16375	COG1045	serine acetyltransferase
GPY06_RS16385	COG0297	glycogen (starch) synthase activity
GPY06_RS16385	COG0438	transferase activity, transferring glycosyl groups
GPY06_RS16395	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPY06_RS16425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY06_RS16435	COG1596	polysaccharide export
GPY06_RS16460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY06_RS16470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY06_RS16475	COG0321	lipoyl(octanoyl) transferase activity
GPY06_RS16480	COG2921	Belongs to the UPF0250 family
GPY06_RS16485	COG1686	Belongs to the peptidase S11 family
GPY06_RS16490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY06_RS16495	COG0772	Belongs to the SEDS family
GPY06_RS16500	COG0768	penicillin binding
GPY06_RS16505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY06_RS16510	COG0799	negative regulation of ribosome biogenesis
GPY06_RS16515	COG1466	dna polymerase III delta subunit
GPY06_RS16520	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY06_RS16525	COG0495	leucyl-tRNA aminoacylation
GPY06_RS16530	COG2888	peptidyl-tyrosine sulfation
GPY06_RS16535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY06_RS16540	COG4535	Mg2 and Co2 transporter CorC
GPY06_RS16545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY06_RS16550	COG1702	phosphate starvation-inducible protein PhoH
GPY06_RS16555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY06_RS16560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY06_RS16565	COG2190	(PTS) system
GPY06_RS16575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS16585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY06_RS16590	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY06_RS16595	COG3115	cell septum assembly
GPY06_RS16600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY06_RS16615	COG0789	Transcriptional regulator
GPY06_RS16620	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPY06_RS16625	COG0330	HflC and HflK could
GPY06_RS16630	COG3118	belongs to the thioredoxin family
GPY06_RS16640	COG0300	oxidoreductase activity
GPY06_RS16645	COG1090	epimerase
GPY06_RS16650	COG0622	Phosphoesterase
GPY06_RS16665	COG3710	Transcriptional regulator
GPY06_RS16670	COG0326	Molecular chaperone. Has ATPase activity
GPY06_RS16675	COG0563	adenylate kinase activity
GPY06_RS16680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY06_RS16685	COG3104	oligopeptide transport
GPY06_RS16690	COG0250	Participates in transcription elongation, termination and antitermination
GPY06_RS16695	COG0367	asparagine synthase
GPY06_RS16700	COG4651	solute:proton antiporter activity
GPY06_RS16700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY06_RS16705	COG1846	Transcriptional regulator
GPY06_RS16705	COG1940	carbohydrate kinase activity
GPY06_RS16710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY06_RS16715	COG2190	(PTS) system
GPY06_RS16715	COG1263	PTS System
GPY06_RS16715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY06_RS16720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY06_RS16730	COG0101	tRNA pseudouridine synthase activity
GPY06_RS16740	COG0285	dihydrofolate synthase activity
GPY06_RS16745	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY06_RS16750	COG1286	toxin biosynthetic process
GPY06_RS16755	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY06_RS16760	COG2056	Na+-H+ antiporter family
GPY06_RS16765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY06_RS16780	COG0346	lactoylglutathione lyase activity
GPY06_RS16785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY06_RS16790	COG4660	Part of a membrane complex involved in electron transport
GPY06_RS16795	COG4659	FMN binding
GPY06_RS16800	COG4658	electron transport chain
GPY06_RS16805	COG4656	Part of a membrane complex involved in electron transport
GPY06_RS16810	COG2878	Part of a membrane complex involved in electron transport
GPY06_RS16815	COG4657	Part of a membrane complex involved in electron transport
GPY06_RS16825	COG0556	nucleotide-excision repair
GPY06_RS16830	COG2204	response regulator
GPY06_RS16835	COG2198	Histidine kinase
GPY06_RS16840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY06_RS16845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY06_RS16850	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY06_RS16855	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY06_RS16860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY06_RS16865	COG0314	molybdopterin synthase activity
GPY06_RS16870	COG2199	diguanylate cyclase activity
GPY06_RS16875	COG0517	IMP dehydrogenase activity
GPY06_RS16875	COG0516	GMP reductase activity
GPY06_RS16885	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY06_RS16895	COG1943	Transposase
GPY06_RS16900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY06_RS16900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY06_RS16910	COG0572	uridine kinase
GPY06_RS16915	COG2982	Protein involved in outer membrane biogenesis
GPY06_RS16920	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY06_RS16925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY06_RS16935	COG2067	long-chain fatty acid transport protein
GPY06_RS16950	COG0183	Belongs to the thiolase family
GPY06_RS16955	COG1024	Enoyl-CoA hydratase
GPY06_RS16955	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY06_RS16960	COG0778	Nitroreductase
GPY06_RS16965	COG0583	DNA-binding transcription factor activity
GPY06_RS16970	COG0745	RESPONSE REGULATOR receiver
GPY06_RS16980	COG2832	Protein of unknown function (DUF454)
GPY06_RS16985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY06_RS16995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY06_RS17000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY06_RS17015	COG1028	Short-chain dehydrogenase reductase Sdr
GPY06_RS17020	COG0616	signal peptide processing
GPY06_RS17030	COG1522	sequence-specific DNA binding
GPY06_RS17035	COG1946	Acyl-CoA thioesterase
GPY06_RS17055	COG5001	Diguanylate cyclase
GPY06_RS17055	COG3300	MHYT domain
GPY06_RS17065	COG0640	Transcriptional regulator
GPY06_RS17070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY06_RS17090	COG1349	DNA-binding transcription factor activity
GPY06_RS17100	COG2222	sugar isomerase
GPY06_RS17105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY06_RS17115	COG3716	PTS system mannose fructose sorbose family IID component
GPY06_RS17120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY06_RS17145	COG1881	PFAM PEBP family protein
GPY06_RS17165	COG0009	L-threonylcarbamoyladenylate synthase
GPY06_RS17180	COG2201	protein-glutamate methylesterase activity
GPY06_RS17190	COG5002	protein histidine kinase activity
GPY06_RS17195	COG4191	Histidine kinase
GPY06_RS17200	COG3300	MHYT domain
GPY06_RS17200	COG5001	Diguanylate cyclase
GPY06_RS17205	COG2204	response regulator
GPY06_RS17210	COG4191	Histidine kinase
GPY06_RS17225	COG0601	transmembrane transport
GPY06_RS17230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY06_RS17235	COG0444	Belongs to the ABC transporter superfamily
GPY06_RS17245	COG0435	Glutathione S-transferase
GPY06_RS17250	COG0280	phosphate acetyltransferase
GPY06_RS17250	COG0857	belongs to the CobB CobQ family
GPY06_RS17255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY06_RS17260	COG3092	negative regulation of chromosome organization
GPY06_RS17265	COG4628	conserved protein (DUF2132)
GPY06_RS17275	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY06_RS17285	COG3706	GGDEF domain
GPY06_RS17290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY06_RS17295	COG0653	protein targeting
GPY06_RS17300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY06_RS17305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY06_RS17310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY06_RS17315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY06_RS17320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY06_RS17325	COG0156	8-amino-7-oxononanoate synthase activity
GPY06_RS17330	COG2226	methyltransferase
GPY06_RS17335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY06_RS17345	COG0501	Belongs to the peptidase M48B family
GPY06_RS17355	COG0300	oxidoreductase activity
GPY06_RS17370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY06_RS17380	COG2268	Band 7 protein
GPY06_RS17390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY06_RS17395	COG2915	High frequency lysogenization protein hflD homolog
GPY06_RS17400	COG0482	sulfurtransferase activity
GPY06_RS17405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY06_RS17410	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY06_RS17415	COG1757	Na H antiporter
GPY06_RS17420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY06_RS17425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY06_RS17430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY06_RS17435	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY06_RS17435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY06_RS17440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY06_RS17445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY06_RS17450	COG0107	imidazoleglycerol-phosphate synthase activity
GPY06_RS17455	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY06_RS17455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY06_RS17460	COG1187	pseudouridine synthase activity
GPY06_RS17470	COG1278	Cold shock
GPY06_RS17475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY06_RS17480	COG0542	response to heat
GPY06_RS17490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY06_RS17495	COG1454	alcohol dehydrogenase
GPY06_RS17495	COG1012	belongs to the aldehyde dehydrogenase family
GPY06_RS17500	COG1737	Transcriptional regulator
GPY06_RS17505	COG0076	glutamate decarboxylase activity
GPY06_RS17515	COG2431	L-lysine efflux transmembrane transporter activity
GPY06_RS17525	COG3070	regulator of competence-specific genes
GPY06_RS17540	COG4191	Histidine kinase
GPY06_RS17540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY06_RS17550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY06_RS17565	COG4067	protein conserved in archaea
GPY06_RS17565	COG0189	ligase activity
GPY06_RS17570	COG0500	methyltransferase
GPY06_RS17575	COG4106	trans-aconitate 2-methyltransferase activity
GPY06_RS17580	COG1801	Protein of unknown function DUF72
GPY06_RS17585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY06_RS17590	COG1435	thymidine kinase activity
GPY06_RS17595	COG1301	dicarboxylic acid transport
GPY06_RS17600	COG0159	tryptophan synthase activity
GPY06_RS17605	COG0133	tryptophan synthase activity
GPY06_RS17610	COG0134	indole-3-glycerol-phosphate synthase activity
GPY06_RS17610	COG0135	phosphoribosylanthranilate isomerase activity
GPY06_RS17615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY06_RS17620	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY06_RS17625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY06_RS17635	COG0613	PHP domain protein
GPY06_RS17640	COG0009	L-threonylcarbamoyladenylate synthase
GPY06_RS17645	COG1187	pseudouridine synthase activity
GPY06_RS17650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY06_RS17655	COG4988	ABC transporter
GPY06_RS17660	COG0492	ferredoxin-NADP+ reductase activity
GPY06_RS17675	COG3706	GGDEF domain
GPY06_RS17680	COG2949	membrane
GPY06_RS17690	COG0281	malic enzyme
GPY06_RS17700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY06_RS17720	COG2885	chlorophyll binding
GPY06_RS17735	COG0277	FAD linked oxidase domain protein
GPY06_RS17735	COG0247	lactate metabolic process
GPY06_RS17755	COG2986	histidine ammonia-lyase
GPY06_RS17760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY06_RS17765	COG0010	Belongs to the arginase family
GPY06_RS17770	COG1228	amidohydrolase
GPY06_RS17790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY06_RS17800	COG5001	Diguanylate cyclase
GPY06_RS17805	COG0417	DNA replication proofreading
GPY06_RS17810	COG2197	response regulator
GPY06_RS17815	COG0322	excinuclease ABC activity
GPY06_RS17845	COG3706	GGDEF domain
GPY06_RS17845	COG0745	RESPONSE REGULATOR receiver
GPY06_RS17850	COG0456	acetyltransferase
GPY06_RS17855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY06_RS17860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY06_RS17860	COG0072	phenylalanine-tRNA ligase activity
GPY06_RS17865	COG0776	regulation of translation
GPY06_RS17875	COG0500	methyltransferase
GPY06_RS17890	COG0295	cytidine deaminase activity
GPY06_RS17895	COG1346	cytolysis
GPY06_RS17905	COG2925	Exonuclease
GPY06_RS17910	COG0582	viral genome integration into host DNA
GPY06_RS17975	COG1484	DNA-dependent DNA replication
GPY06_RS18150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY06_RS18165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY06_RS18170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY06_RS18175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY06_RS18190	COG2988	succinylglutamate desuccinylase activity
GPY06_RS18195	COG4139	cobalamin transport
GPY06_RS18200	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY06_RS18250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY06_RS18255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY06_RS18275	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY06_RS18280	COG0437	4 iron, 4 sulfur cluster binding
GPY06_RS18285	COG3301	Polysulphide reductase, NrfD
GPY06_RS18290	COG1138	Cytochrome C-type biogenesis protein
GPY06_RS18300	COG4235	cytochrome complex assembly
GPY06_RS18300	COG3088	subunit of a heme lyase
GPY06_RS18310	COG1278	Cold shock
GPY06_RS18325	COG2814	Major facilitator Superfamily
GPY06_RS18335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY06_RS18365	COG3108	Peptidase M15
GPY06_RS18370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY06_RS18385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY06_RS18410	COG1846	Transcriptional regulator
GPY06_RS18415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY06_RS18420	COG0726	polysaccharide deacetylase
GPY06_RS18425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY06_RS18435	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY06_RS18440	COG1486	melibiose metabolic process
GPY06_RS18445	COG3394	polysaccharide catabolic process
GPY06_RS18455	COG2943	transferase activity, transferring hexosyl groups
GPY06_RS18460	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPY06_RS18465	COG0840	transmembrane signaling receptor activity
GPY06_RS18470	COG1943	Transposase
GPY06_RS18485	COG1448	Aminotransferase
GPY06_RS18490	COG0110	maltose O-acetyltransferase activity
GPY06_RS18495	COG0351	phosphomethylpyrimidine kinase
GPY06_RS18500	COG0017	Asparaginyl-tRNA synthetase
GPY06_RS18505	COG0840	transmembrane signaling receptor activity
GPY06_RS18510	COG0720	synthase
GPY06_RS18515	COG1760	l-serine dehydratase
GPY06_RS18520	COG0814	amino acid
GPY06_RS18525	COG0494	nUDIX hydrolase
GPY06_RS18530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY06_RS18545	COG3106	COG3106 Predicted ATPase
GPY06_RS18550	COG3768	UPF0283 membrane protein
GPY06_RS18555	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY06_RS18560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY06_RS18580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY06_RS18590	COG0471	metal ion transport
GPY06_RS18595	COG4191	Histidine kinase
GPY06_RS18595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY06_RS18610	COG3713	MltA-interacting MipA family protein
GPY06_RS18615	COG5002	protein histidine kinase activity
GPY06_RS18620	COG0745	RESPONSE REGULATOR receiver
GPY06_RS18645	COG1129	ABC transporter
GPY06_RS18690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY06_RS18695	COG2186	Transcriptional regulator
GPY06_RS18700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY06_RS18705	COG0372	Belongs to the citrate synthase family
GPY06_RS18750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY06_RS18775	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY06_RS18785	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY06_RS18795	COG0625	glutathione transferase activity
GPY06_RS18800	COG3437	response regulator, receiver
GPY06_RS18815	COG3706	GGDEF domain
GPY06_RS18820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY06_RS18830	COG1254	Belongs to the acylphosphatase family
GPY06_RS18835	COG2920	part of a sulfur-relay system
GPY06_RS18840	COG0670	Belongs to the BI1 family
GPY06_RS18845	COG1126	abc transporter atp-binding protein
GPY06_RS18850	COG0765	amino acid transport
GPY06_RS18855	COG4597	amino acid ABC transporter
GPY06_RS18860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY06_RS18870	COG0561	phosphatase activity
GPY06_RS18875	COG0602	queuosine metabolic process
GPY06_RS18880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY06_RS18895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY06_RS18910	COG3706	GGDEF domain
GPY06_RS18915	COG0443	Heat shock 70 kDa protein
GPY06_RS18930	COG3706	GGDEF domain
GPY06_RS18960	COG1643	Atp-dependent helicase
GPY06_RS18985	COG0402	S-adenosylhomocysteine deaminase activity
GPY06_RS18990	COG0443	Heat shock 70 kDa protein
GPY06_RS18995	COG0095	Lipoate-protein ligase
GPY06_RS19005	COG0583	DNA-binding transcription factor activity
GPY06_RS19015	COG2076	Multidrug Resistance protein
GPY06_RS19035	COG0643	Histidine kinase
GPY06_RS19035	COG2198	Histidine kinase
GPY06_RS19045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY06_RS19055	COG2201	protein-glutamate methylesterase activity
GPY06_RS19060	COG0835	chemotaxis
GPY06_RS19065	COG0840	transmembrane signaling receptor activity
GPY06_RS19080	COG0513	Belongs to the DEAD box helicase family
GPY06_RS19090	COG1538	Outer membrane efflux protein
GPY06_RS19095	COG1566	PFAM secretion protein HlyD family protein
GPY06_RS19100	COG2814	Major facilitator Superfamily
GPY06_RS19110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY06_RS19120	COG3501	Rhs element vgr protein
GPY06_RS19140	COG1280	lysine exporter protein (LysE YggA)
GPY06_RS19145	COG1115	amino acid carrier protein
GPY06_RS19160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY06_RS19165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY06_RS19170	COG1177	transmembrane transport
GPY06_RS19175	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY06_RS19180	COG3842	ATPase activity
GPY06_RS19200	COG0037	tRNA processing
GPY06_RS19205	COG0589	response to stress
GPY06_RS19210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY06_RS19225	COG2217	Heavy metal translocating P-type atpase
GPY06_RS19235	COG2010	Cytochrome c
GPY06_RS19250	COG3278	Belongs to the heme-copper respiratory oxidase family