locus-tag	class	description
EPB59_RS00015	COG1129	ABC transporter
EPB59_RS00020	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB59_RS00025	COG1472	Belongs to the glycosyl hydrolase 3 family
EPB59_RS00030	COG2199	diguanylate cyclase activity
EPB59_RS00045	COG2233	PERMEase
EPB59_RS00050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPB59_RS00055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB59_RS00060	COG1758	RNA polymerase activity
EPB59_RS00065	COG0194	GDP metabolic process
EPB59_RS00070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EPB59_RS00075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB59_RS00095	COG4232	protein-disulfide reductase activity
EPB59_RS00100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB59_RS00105	COG1027	Aspartate ammonia-lyase
EPB59_RS00120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPB59_RS00125	COG2205	protein histidine kinase activity
EPB59_RS00130	COG0745	RESPONSE REGULATOR receiver
EPB59_RS00145	COG0205	6-phosphofructokinase activity
EPB59_RS00150	COG1494	fructose-1,6-bisphosphatase
EPB59_RS00155	COG3074	FtsZ-dependent cytokinesis
EPB59_RS00160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPB59_RS00165	COG0527	aspartate kinase activity
EPB59_RS00165	COG0460	homoserine dehydrogenase
EPB59_RS00170	COG0626	cystathionine gamma-synthase activity
EPB59_RS00175	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EPB59_RS00180	COG0281	malic enzyme
EPB59_RS00190	COG0254	rRNA binding
EPB59_RS00195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPB59_RS00200	COG1609	Transcriptional regulator
EPB59_RS00205	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPB59_RS00215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EPB59_RS00220	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EPB59_RS00225	COG1575	Belongs to the MenA family. Type 1 subfamily
EPB59_RS00230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB59_RS00235	COG0534	Mate efflux family protein
EPB59_RS00240	COG0149	triose-phosphate isomerase activity
EPB59_RS00265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPB59_RS00270	COG0459	protein refolding
EPB59_RS00280	COG1509	lysine 2,3-aminomutase activity
EPB59_RS00285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPB59_RS00295	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EPB59_RS00300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB59_RS00305	COG1053	succinate dehydrogenase
EPB59_RS00310	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EPB59_RS00315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB59_RS00320	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EPB59_RS00325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPB59_RS00330	COG1045	serine acetyltransferase
EPB59_RS00340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EPB59_RS00345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB59_RS00350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPB59_RS00355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB59_RS00360	COG0137	argininosuccinate synthase activity
EPB59_RS00365	COG0165	Argininosuccinate lyase
EPB59_RS00375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB59_RS00380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB59_RS00380	COG0678	peroxiredoxin activity
EPB59_RS00420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPB59_RS00425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPB59_RS00435	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EPB59_RS00440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPB59_RS00445	COG0546	phosphoglycolate phosphatase activity
EPB59_RS00450	COG0180	Tryptophanyl-tRNA synthetase
EPB59_RS00465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPB59_RS00470	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB59_RS00480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPB59_RS00505	COG3954	Phosphoribulokinase
EPB59_RS00515	COG0429	hydrolase of the alpha beta-hydrolase fold
EPB59_RS00525	COG0488	(ABC) transporter
EPB59_RS00530	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB59_RS00545	COG1047	Peptidyl-prolyl cis-trans
EPB59_RS00550	COG1446	asparaginase
EPB59_RS00560	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EPB59_RS00565	COG3083	sulfuric ester hydrolase activity
EPB59_RS00570	COG0557	exoribonuclease II activity
EPB59_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB59_RS00580	COG0051	transcription antitermination factor activity, RNA binding
EPB59_RS00585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPB59_RS00590	COG0088	Forms part of the polypeptide exit tunnel
EPB59_RS00595	COG0089	rRNA binding
EPB59_RS00600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPB59_RS00605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPB59_RS00610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPB59_RS00615	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EPB59_RS00620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EPB59_RS00625	COG0255	Belongs to the universal ribosomal protein uL29 family
EPB59_RS00630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPB59_RS00635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EPB59_RS00640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPB59_RS00645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPB59_RS00650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPB59_RS00655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPB59_RS00665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EPB59_RS00670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EPB59_RS00675	COG1841	ribosomal large subunit assembly
EPB59_RS00685	COG0201	protein transport
EPB59_RS00690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPB59_RS00695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPB59_RS00700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPB59_RS00705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EPB59_RS00710	COG0202	RNA polymerase activity
EPB59_RS00715	COG0203	ribosomal protein L17
EPB59_RS00725	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB59_RS00730	COG3061	Opacity-associated protein A
EPB59_RS00730	COG3266	domain, Protein
EPB59_RS00735	COG0697	spore germination
EPB59_RS00740	COG2153	protein acetylation
EPB59_RS00745	COG0513	Belongs to the DEAD box helicase family
EPB59_RS00755	COG0737	Belongs to the 5'-nucleotidase family
EPB59_RS00760	COG1648	precorrin-2 dehydrogenase activity
EPB59_RS00760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPB59_RS00765	COG0175	sulfate reduction
EPB59_RS00770	COG2895	sulfate adenylyltransferase (ATP) activity
EPB59_RS00775	COG0529	Catalyzes the synthesis of activated sulfate
EPB59_RS00795	COG0577	efflux transmembrane transporter activity
EPB59_RS00795	COG1136	(ABC) transporter
EPB59_RS00810	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EPB59_RS00815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB59_RS00820	COG0729	surface antigen
EPB59_RS00825	COG2911	Protein conserved in bacteria
EPB59_RS00830	COG2105	PFAM AIG2 family protein
EPB59_RS00835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPB59_RS00840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPB59_RS00845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB59_RS00850	COG0163	prenyltransferase activity
EPB59_RS00860	COG1178	ABC-type Fe3 transport system permease component
EPB59_RS00865	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EPB59_RS00870	COG3028	Belongs to the UPF0307 family
EPB59_RS00875	COG0312	modulator of DNA gyrase
EPB59_RS00880	COG2239	Acts as a magnesium transporter
EPB59_RS00885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB59_RS00890	COG1660	Displays ATPase and GTPase activities
EPB59_RS00895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB59_RS00900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB59_RS00910	COG1137	ATPase activity
EPB59_RS00915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPB59_RS00930	COG0517	IMP dehydrogenase activity
EPB59_RS00930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPB59_RS00940	COG1127	ABC transporter
EPB59_RS00945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPB59_RS00950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB59_RS00955	COG2854	intermembrane phospholipid transfer
EPB59_RS00965	COG5007	Belongs to the BolA IbaG family
EPB59_RS00970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPB59_RS00975	COG0204	Acyl-transferase
EPB59_RS00980	COG0251	oxidation-reduction process
EPB59_RS00990	COG0540	Belongs to the ATCase OTCase family
EPB59_RS01000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EPB59_RS01005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPB59_RS01010	COG0564	pseudouridine synthase activity
EPB59_RS01015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB59_RS01020	COG4269	membrane
EPB59_RS01030	COG0525	valine-tRNA ligase activity
EPB59_RS01035	COG2927	DNA polymerase III (CHI subunit)
EPB59_RS01040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB59_RS01045	COG0795	lipopolysaccharide-transporting ATPase activity
EPB59_RS01050	COG0795	lipopolysaccharide-transporting ATPase activity
EPB59_RS01065	COG3437	response regulator, receiver
EPB59_RS01115	COG0066	3-isopropylmalate dehydratase activity
EPB59_RS01120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPB59_RS01125	COG0473	3-isopropylmalate dehydrogenase activity
EPB59_RS01150	COG0583	DNA-binding transcription factor activity
EPB59_RS01155	COG1022	Amp-dependent synthetase and ligase
EPB59_RS01160	COG0028	Belongs to the TPP enzyme family
EPB59_RS01165	COG0440	acetolactate synthase activity
EPB59_RS01170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB59_RS01175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EPB59_RS01180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPB59_RS01190	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EPB59_RS01195	COG3079	Belongs to the UPF0149 family
EPB59_RS01200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB59_RS01205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB59_RS01220	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EPB59_RS01230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPB59_RS01235	COG1595	DNA-templated transcription, initiation
EPB59_RS01250	COG3086	response to oxidative stress
EPB59_RS01255	COG0481	GTPase activity
EPB59_RS01270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPB59_RS01275	COG1381	Involved in DNA repair and RecF pathway recombination
EPB59_RS01280	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPB59_RS01285	COG0736	holo-[acyl-carrier-protein] synthase activity
EPB59_RS01300	COG5001	Diguanylate cyclase
EPB59_RS01305	COG2205	protein histidine kinase activity
EPB59_RS01305	COG4999	Histidine kinase
EPB59_RS01305	COG3437	response regulator, receiver
EPB59_RS01305	COG3850	Histidine kinase
EPB59_RS01315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB59_RS01320	COG3956	TIGRFAM MazG family protein
EPB59_RS01325	COG0504	CTP synthase activity
EPB59_RS01330	COG0148	phosphopyruvate hydratase activity
EPB59_RS01335	COG0617	tRNA 3'-terminal CCA addition
EPB59_RS01340	COG3409	Peptidoglycan-binding domain 1 protein
EPB59_RS01340	COG3267	Type II secretory pathway component ExeA
EPB59_RS01350	COG4991	sh3 domain protein
EPB59_RS01355	COG0306	phosphate transporter
EPB59_RS01360	COG1392	Phosphate transport regulator
EPB59_RS01365	COG3025	triphosphatase activity
EPB59_RS01375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EPB59_RS01380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPB59_RS01380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPB59_RS01385	COG1538	Outer membrane efflux protein
EPB59_RS01390	COG0494	nUDIX hydrolase
EPB59_RS01395	COG3151	Protein conserved in bacteria
EPB59_RS01405	COG3150	esterase
EPB59_RS01410	COG0187	DNA topoisomerase II activity
EPB59_RS01415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EPB59_RS01425	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EPB59_RS01430	COG0237	dephospho-CoA kinase activity
EPB59_RS01440	COG1459	type II secretion system
EPB59_RS01445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB59_RS01455	COG0157	Belongs to the NadC ModD family
EPB59_RS01465	COG0716	FMN binding
EPB59_RS01470	COG4974	Belongs to the 'phage' integrase family
EPB59_RS01475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB59_RS01480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPB59_RS01485	COG0737	Belongs to the 5'-nucleotidase family
EPB59_RS01490	COG2186	Transcriptional regulator
EPB59_RS01495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EPB59_RS01500	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB59_RS01505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB59_RS01520	COG3116	cell division
EPB59_RS01525	COG0768	penicillin binding
EPB59_RS01530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPB59_RS01535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPB59_RS01545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPB59_RS01550	COG0772	Belongs to the SEDS family
EPB59_RS01555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPB59_RS01560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB59_RS01565	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPB59_RS01570	COG0849	cell division
EPB59_RS01575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPB59_RS01580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPB59_RS01590	COG0653	protein targeting
EPB59_RS01595	COG0494	nUDIX hydrolase
EPB59_RS01600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EPB59_RS01610	COG0505	Belongs to the CarA family
EPB59_RS01615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPB59_RS01620	COG0730	response to heat
EPB59_RS01625	COG0583	DNA-binding transcription factor activity
EPB59_RS01630	COG2860	membrane
EPB59_RS01635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB59_RS01645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB59_RS01655	COG0493	'glutamate synthase
EPB59_RS01660	COG0070	glutamate synthase
EPB59_RS01660	COG0069	glutamate synthase activity
EPB59_RS01660	COG0067	glutamate synthase
EPB59_RS01670	COG0070	glutamate synthase
EPB59_RS01670	COG0067	glutamate synthase
EPB59_RS01670	COG0069	glutamate synthase activity
EPB59_RS01675	COG1242	4 iron, 4 sulfur cluster binding
EPB59_RS01680	COG4251	negative regulation of phosphorylation
EPB59_RS01680	COG5001	Diguanylate cyclase
EPB59_RS01680	COG3706	GGDEF domain
EPB59_RS01680	COG2203	Gaf domain
EPB59_RS01685	COG2198	Histidine kinase
EPB59_RS01685	COG0784	Response regulator, receiver
EPB59_RS01685	COG5002	protein histidine kinase activity
EPB59_RS01690	COG0745	RESPONSE REGULATOR receiver
EPB59_RS01700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB59_RS01720	COG0083	homoserine kinase activity
EPB59_RS01725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPB59_RS01730	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EPB59_RS01735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EPB59_RS01740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPB59_RS01755	COG1115	amino acid carrier protein
EPB59_RS01760	COG3022	response to hydroperoxide
EPB59_RS01765	COG0084	hydrolase, TatD family'
EPB59_RS01770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB59_RS01780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EPB59_RS01785	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EPB59_RS01790	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EPB59_RS01795	COG0813	purine-nucleoside phosphorylase activity
EPB59_RS01805	COG0560	Phosphoserine phosphatase
EPB59_RS01815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPB59_RS01820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB59_RS01825	COG1022	Amp-dependent synthetase and ligase
EPB59_RS01840	COG3250	beta-galactosidase activity
EPB59_RS01845	COG1609	Transcriptional regulator
EPB59_RS01850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB59_RS01865	COG0189	ligase activity
EPB59_RS01865	COG0569	domain protein
EPB59_RS01870	COG0456	acetyltransferase
EPB59_RS01880	COG2171	N-acyltransferase activity
EPB59_RS01885	COG3141	response to X-ray
EPB59_RS01890	COG0583	DNA-binding transcription factor activity
EPB59_RS01900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EPB59_RS01910	COG1074	ATP-dependent DNA helicase activity
EPB59_RS01915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB59_RS01925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB59_RS01925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB59_RS01935	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EPB59_RS01940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPB59_RS01945	COG2166	iron-sulfur cluster assembly
EPB59_RS01950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPB59_RS01955	COG0693	protein deglycase activity
EPB59_RS01960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EPB59_RS01975	COG1595	DNA-templated transcription, initiation
EPB59_RS01985	COG2211	Major facilitator Superfamily
EPB59_RS02000	COG2813	Specifically methylates the guanine in position
EPB59_RS02005	COG0271	Belongs to the BolA IbaG family
EPB59_RS02010	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB59_RS02015	COG1805	sodium ion transport
EPB59_RS02020	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB59_RS02025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB59_RS02030	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB59_RS02035	COG2871	sodium ion transport
EPB59_RS02040	COG1477	protein flavinylation
EPB59_RS02060	COG2203	Gaf domain
EPB59_RS02060	COG3706	GGDEF domain
EPB59_RS02060	COG4251	negative regulation of phosphorylation
EPB59_RS02060	COG5001	Diguanylate cyclase
EPB59_RS02065	COG0733	neurotransmitter:sodium symporter activity
EPB59_RS02075	COG0189	ligase activity
EPB59_RS02080	COG4067	protein conserved in archaea
EPB59_RS02080	COG0189	ligase activity
EPB59_RS02085	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB59_RS02090	COG2252	PERMEase
EPB59_RS02095	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EPB59_RS02100	COG1073	alpha beta
EPB59_RS02110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EPB59_RS02115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPB59_RS02120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPB59_RS02125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB59_RS02125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB59_RS02140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EPB59_RS02145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB59_RS02150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPB59_RS02155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EPB59_RS02165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EPB59_RS02170	COG0024	Methionine aminopeptidase
EPB59_RS02175	COG0052	Belongs to the universal ribosomal protein uS2 family
EPB59_RS02180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPB59_RS02185	COG0528	UMP kinase activity
EPB59_RS02190	COG0233	cytoplasmic translational termination
EPB59_RS02195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPB59_RS02200	COG0575	Belongs to the CDS family
EPB59_RS02205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPB59_RS02210	COG0750	zinc metalloprotease
EPB59_RS02220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EPB59_RS02225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB59_RS02230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB59_RS02235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB59_RS02240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB59_RS02245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPB59_RS02250	COG0587	DNA-directed DNA polymerase activity
EPB59_RS02255	COG0825	malonyl-CoA metabolic process
EPB59_RS02260	COG0037	tRNA processing
EPB59_RS02270	COG0347	Belongs to the P(II) protein family
EPB59_RS02275	COG3021	interspecies interaction between organisms
EPB59_RS02280	COG0741	lytic transglycosylase activity
EPB59_RS02280	COG1388	LysM domain
EPB59_RS02285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB59_RS02290	COG2226	methyltransferase
EPB59_RS02295	COG0328	RNA-DNA hybrid ribonuclease activity
EPB59_RS02310	COG1960	acyl-CoA dehydrogenase activity
EPB59_RS02315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB59_RS02320	COG0121	glutamine amidotransferase
EPB59_RS02330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EPB59_RS02335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPB59_RS02340	COG3706	GGDEF domain
EPB59_RS02345	COG1187	pseudouridine synthase activity
EPB59_RS02350	COG2840	Smr protein MutS2
EPB59_RS02380	COG2608	mercury ion transmembrane transporter activity
EPB59_RS02380	COG2217	Heavy metal translocating P-type atpase
EPB59_RS02385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB59_RS02425	COG2747	anti-sigma28 factor FlgM
EPB59_RS02435	COG0784	Response regulator, receiver
EPB59_RS02435	COG0835	chemotaxis
EPB59_RS02440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPB59_RS02445	COG1815	bacterial-type flagellum-dependent cell motility
EPB59_RS02460	COG1749	Flagellar hook protein flgE
EPB59_RS02465	COG4787	bacterial-type flagellum-dependent cell motility
EPB59_RS02475	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB59_RS02480	COG1706	bacterial-type flagellum-dependent cell motility
EPB59_RS02485	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPB59_RS02485	COG3951	Flagellar rod assembly protein muramidase FlgJ
EPB59_RS02500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB59_RS02505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB59_RS02590	COG0012	GTP binding
EPB59_RS02595	COG0193	aminoacyl-tRNA hydrolase activity
EPB59_RS02600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPB59_RS02610	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EPB59_RS02615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPB59_RS02620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPB59_RS02625	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB59_RS02635	COG2912	Transglutaminase-like superfamily
EPB59_RS02640	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPB59_RS02645	COG0737	Belongs to the 5'-nucleotidase family
EPB59_RS02655	COG2233	PERMEase
EPB59_RS02680	COG4783	chaperone-mediated protein folding
EPB59_RS02700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPB59_RS02715	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EPB59_RS02725	COG1876	peptidase activity
EPB59_RS02735	COG1393	Belongs to the ArsC family
EPB59_RS02755	COG2837	iron assimilation
EPB59_RS02760	COG2706	6-phosphogluconolactonase activity
EPB59_RS02770	COG0800	Aldolase
EPB59_RS02780	COG4145	pantothenate transmembrane transporter activity
EPB59_RS02790	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EPB59_RS02800	COG1737	Transcriptional regulator
EPB59_RS02800	COG0837	glucose binding
EPB59_RS02805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB59_RS02810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB59_RS02815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB59_RS02825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB59_RS02835	COG1516	flagellar protein fliS
EPB59_RS02855	COG1677	Flagellar hook-basal body complex protein FliE
EPB59_RS02865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPB59_RS02870	COG1317	bacterial-type flagellum organization
EPB59_RS02915	COG1987	bacterial-type flagellum assembly
EPB59_RS02930	COG2840	Smr protein MutS2
EPB59_RS02935	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB59_RS02940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPB59_RS02945	COG2860	membrane
EPB59_RS02950	COG3101	peptidyl-lysine hydroxylation
EPB59_RS02960	COG0431	NADPH-dependent FMN reductase
EPB59_RS02970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB59_RS02975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB59_RS02980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB59_RS02985	COG0735	belongs to the Fur family
EPB59_RS02995	COG0583	DNA-binding transcription factor activity
EPB59_RS03005	COG1346	cytolysis
EPB59_RS03020	COG0596	Alpha beta hydrolase
EPB59_RS03025	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EPB59_RS03030	COG0033	Phosphoglucomutase
EPB59_RS03040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPB59_RS03045	COG0372	Belongs to the citrate synthase family
EPB59_RS03055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPB59_RS03060	COG1053	succinate dehydrogenase
EPB59_RS03070	COG0567	Dehydrogenase, E1 component
EPB59_RS03075	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB59_RS03080	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB59_RS03090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB59_RS03100	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EPB59_RS03105	COG4977	sequence-specific DNA binding
EPB59_RS03110	COG1918	ferrous iron import across plasma membrane
EPB59_RS03130	COG0018	arginyl-trna synthetase
EPB59_RS03140	COG1025	Belongs to the peptidase M16 family
EPB59_RS03145	COG2062	phosphohistidine phosphatase, SixA
EPB59_RS03175	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EPB59_RS03180	COG0643	Histidine kinase
EPB59_RS03180	COG0784	Response regulator, receiver
EPB59_RS03180	COG2198	Histidine kinase
EPB59_RS03185	COG2201	protein-glutamate methylesterase activity
EPB59_RS03190	COG1192	Involved in chromosome partitioning
EPB59_RS03200	COG0835	chemotaxis
EPB59_RS03215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB59_RS03220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB59_RS03230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EPB59_RS03235	COG1138	Cytochrome C-type biogenesis protein
EPB59_RS03240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPB59_RS03245	COG4235	cytochrome complex assembly
EPB59_RS03245	COG3088	subunit of a heme lyase
EPB59_RS03250	COG4235	cytochrome complex assembly
EPB59_RS03255	COG2853	Lipoprotein
EPB59_RS03275	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPB59_RS03280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB59_RS03285	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPB59_RS03300	COG3083	sulfuric ester hydrolase activity
EPB59_RS03305	COG3082	Protein of unknown function (DUF1414)
EPB59_RS03310	COG3081	Nucleoid-associated protein
EPB59_RS03320	COG1757	Na H antiporter
EPB59_RS03325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB59_RS03330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB59_RS03335	COG2095	MarC family integral membrane protein
EPB59_RS03340	COG1454	alcohol dehydrogenase
EPB59_RS03340	COG1012	belongs to the aldehyde dehydrogenase family
EPB59_RS03350	COG0659	secondary active sulfate transmembrane transporter activity
EPB59_RS03355	COG1530	ribonuclease E activity
EPB59_RS03360	COG0564	pseudouridine synthase activity
EPB59_RS03365	COG0424	maF-like protein
EPB59_RS03370	COG1399	metal-binding, possibly nucleic acid-binding protein
EPB59_RS03375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EPB59_RS03380	COG0416	fatty acid biosynthetic process
EPB59_RS03385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB59_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
EPB59_RS03400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB59_RS03405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB59_RS03410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPB59_RS03415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPB59_RS03420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPB59_RS03425	COG0470	DNA polymerase III
EPB59_RS03430	COG0084	hydrolase, TatD family'
EPB59_RS03435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB59_RS03435	COG1263	PTS System
EPB59_RS03450	COG0733	neurotransmitter:sodium symporter activity
EPB59_RS03465	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB59_RS03475	COG1940	carbohydrate kinase activity
EPB59_RS03480	COG0835	chemotaxis
EPB59_RS03480	COG0784	Response regulator, receiver
EPB59_RS03510	COG2226	methyltransferase
EPB59_RS03525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB59_RS03530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB59_RS03540	COG3139	Protein of unknown function (DUF1315)
EPB59_RS03545	COG0252	asparaginase activity
EPB59_RS03550	COG0616	signal peptide processing
EPB59_RS03555	COG1902	pentaerythritol trinitrate reductase activity
EPB59_RS03555	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB59_RS03560	COG0788	formyltetrahydrofolate deformylase activity
EPB59_RS03570	COG1199	ATP-dependent helicase activity
EPB59_RS03575	COG1214	PFAM Peptidase M22, glycoprotease
EPB59_RS03590	COG0596	Alpha beta hydrolase
EPB59_RS03595	COG0318	PFAM AMP-dependent synthetase and ligase
EPB59_RS03600	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EPB59_RS03610	COG0705	Rhomboid family
EPB59_RS03620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EPB59_RS03625	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EPB59_RS03630	COG0436	Aminotransferase
EPB59_RS03635	COG1169	isochorismate synthase
EPB59_RS03640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EPB59_RS03645	COG0596	Alpha beta hydrolase
EPB59_RS03665	COG3135	benzoate transporter
EPB59_RS03670	COG0477	Major facilitator Superfamily
EPB59_RS03690	COG3015	lipoprotein NlpE involved in copper resistance
EPB59_RS03695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EPB59_RS03700	COG2894	cell division
EPB59_RS03705	COG0850	regulation of cytokinetic process
EPB59_RS03710	COG3100	YcgL domain-containing protein
EPB59_RS03715	COG2951	lytic endotransglycosylase activity
EPB59_RS03725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB59_RS03730	COG3325	Belongs to the glycosyl hydrolase 18 family
EPB59_RS03730	COG3469	chitinase activity
EPB59_RS03735	COG3005	denitrification pathway
EPB59_RS03740	COG0243	molybdopterin cofactor binding
EPB59_RS03745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPB59_RS03775	COG4264	IucA IucC family
EPB59_RS03785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB59_RS03790	COG1120	ATPase activity
EPB59_RS03835	COG3842	ATPase activity
EPB59_RS03850	COG0671	phosphoesterase, PA-phosphatase related
EPB59_RS03865	COG4589	Belongs to the CDS family
EPB59_RS03875	COG5001	Diguanylate cyclase
EPB59_RS03875	COG3300	MHYT domain
EPB59_RS03890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPB59_RS03895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB59_RS03900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB59_RS03905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB59_RS03915	COG4191	Histidine kinase
EPB59_RS03925	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPB59_RS03935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPB59_RS03940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPB59_RS03945	COG0776	regulation of translation
EPB59_RS03950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB59_RS03955	COG1555	photosystem II stabilization
EPB59_RS03960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPB59_RS03965	COG0539	negative regulation of cytoplasmic translation
EPB59_RS03970	COG0776	regulation of translation
EPB59_RS03975	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EPB59_RS03980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EPB59_RS04000	COG0583	DNA-binding transcription factor activity
EPB59_RS04010	COG0686	Belongs to the AlaDH PNT family
EPB59_RS04015	COG1522	sequence-specific DNA binding
EPB59_RS04020	COG1674	ftsk spoiiie
EPB59_RS04025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EPB59_RS04030	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB59_RS04035	COG2186	Transcriptional regulator
EPB59_RS04050	COG0537	adenosine 5'-monophosphoramidase activity
EPB59_RS04075	COG3150	esterase
EPB59_RS04080	COG1252	NADH dehydrogenase
EPB59_RS04100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPB59_RS04110	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB59_RS04115	COG1136	(ABC) transporter
EPB59_RS04120	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB59_RS04130	COG2333	competence protein COMEC
EPB59_RS04130	COG0658	competence protein
EPB59_RS04135	COG1132	(ABC) transporter
EPB59_RS04140	COG1663	tetraacyldisaccharide 4'-kinase activity
EPB59_RS04145	COG2835	tetraacyldisaccharide 4'-kinase activity
EPB59_RS04150	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPB59_RS04155	COG2719	SpoVR family
EPB59_RS04160	COG2718	Belongs to the UPF0229 family
EPB59_RS04165	COG2766	serine protein kinase
EPB59_RS04170	COG3013	Belongs to the UPF0304 family
EPB59_RS04180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB59_RS04185	COG0840	transmembrane signaling receptor activity
EPB59_RS04195	COG1882	Formate acetyltransferase
EPB59_RS04220	COG4160	amino acid transport
EPB59_RS04225	COG0708	Exodeoxyribonuclease III
EPB59_RS04230	COG0840	transmembrane signaling receptor activity
EPB59_RS04240	COG3923	Primosomal replication protein n
EPB59_RS04245	COG0730	response to heat
EPB59_RS04250	COG1199	ATP-dependent helicase activity
EPB59_RS04255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB59_RS04260	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB59_RS04265	COG3012	SEC-C Motif Domain Protein
EPB59_RS04270	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB59_RS04275	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB59_RS04280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB59_RS04285	COG0215	cysteine-tRNA ligase activity
EPB59_RS04290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EPB59_RS04295	COG0632	four-way junction helicase activity
EPB59_RS04305	COG1271	oxidase subunit
EPB59_RS04310	COG1294	oxidase, subunit
EPB59_RS04315	COG4890	Cyd operon protein YbgT
EPB59_RS04325	COG0824	Thioesterase
EPB59_RS04330	COG0811	peptide transport
EPB59_RS04345	COG0823	Involved in the tonB-independent uptake of proteins
EPB59_RS04350	COG2885	chlorophyll binding
EPB59_RS04360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPB59_RS04370	COG0784	Response regulator, receiver
EPB59_RS04370	COG5002	protein histidine kinase activity
EPB59_RS04380	COG1482	cell wall glycoprotein biosynthetic process
EPB59_RS04385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB59_RS04385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB59_RS04385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB59_RS04390	COG2207	Transcriptional regulator
EPB59_RS04400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB59_RS04405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB59_RS04410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB59_RS04420	COG1012	belongs to the aldehyde dehydrogenase family
EPB59_RS04425	COG3284	Transcriptional regulator
EPB59_RS04430	COG4628	conserved protein (DUF2132)
EPB59_RS04440	COG0415	Belongs to the DNA photolyase family
EPB59_RS04460	COG4409	exo-alpha-(2->6)-sialidase activity
EPB59_RS04465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPB59_RS04470	COG1940	carbohydrate kinase activity
EPB59_RS04485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB59_RS04490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB59_RS04495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB59_RS04500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPB59_RS04505	COG1737	Transcriptional regulator
EPB59_RS04510	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EPB59_RS04515	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EPB59_RS04555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EPB59_RS04565	COG0582	viral genome integration into host DNA
EPB59_RS04580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB59_RS04600	COG1012	belongs to the aldehyde dehydrogenase family
EPB59_RS04620	COG1960	acyl-CoA dehydrogenase activity
EPB59_RS04625	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB59_RS04630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPB59_RS04635	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EPB59_RS04640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPB59_RS04655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB59_RS04660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB59_RS04665	COG0297	glycogen (starch) synthase activity
EPB59_RS04685	COG3070	regulator of competence-specific genes
EPB59_RS04690	COG1609	Transcriptional regulator
EPB59_RS04695	COG3381	protein complex oligomerization
EPB59_RS04700	COG0745	RESPONSE REGULATOR receiver
EPB59_RS04705	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB59_RS04710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB59_RS04715	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EPB59_RS04720	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EPB59_RS04730	COG1979	alcohol dehydrogenase
EPB59_RS04735	COG2207	Transcriptional regulator
EPB59_RS04755	COG1032	radical SAM domain protein
EPB59_RS04760	COG2203	Gaf domain
EPB59_RS04760	COG2200	EAL domain
EPB59_RS04760	COG2199	diguanylate cyclase activity
EPB59_RS04765	COG0612	Peptidase, M16
EPB59_RS04780	COG0583	DNA-binding transcription factor activity
EPB59_RS04785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPB59_RS04795	COG2350	Protein conserved in bacteria
EPB59_RS04820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB59_RS04825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB59_RS04835	COG2116	formate transmembrane transporter activity
EPB59_RS04840	COG4459	periplasmic nitrate reductase
EPB59_RS04845	COG3005	denitrification pathway
EPB59_RS04850	COG0243	molybdopterin cofactor binding
EPB59_RS04865	COG1162	GTPase activity
EPB59_RS04870	COG1227	inorganic diphosphatase activity
EPB59_RS04885	COG4172	Belongs to the ABC transporter superfamily
EPB59_RS04895	COG4171	peptide transport system, permease
EPB59_RS04900	COG4168	peptide transport system, permease
EPB59_RS04910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EPB59_RS04915	COG1842	Phage shock protein A
EPB59_RS04930	COG2818	Glycosylase
EPB59_RS04935	COG0626	cystathionine gamma-synthase activity
EPB59_RS04945	COG0733	neurotransmitter:sodium symporter activity
EPB59_RS04950	COG0564	pseudouridine synthase activity
EPB59_RS04955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPB59_RS04960	COG4136	ATPase activity
EPB59_RS04980	COG3313	Fe-S protein
EPB59_RS04990	COG0842	Transport permease protein
EPB59_RS04995	COG1131	(ABC) transporter
EPB59_RS05005	COG0814	amino acid
EPB59_RS05015	COG2239	Acts as a magnesium transporter
EPB59_RS05020	COG0784	Response regulator, receiver
EPB59_RS05020	COG2205	protein histidine kinase activity
EPB59_RS05035	COG4934	collagen metabolic process
EPB59_RS05060	COG0840	transmembrane signaling receptor activity
EPB59_RS05065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB59_RS05085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPB59_RS05105	COG1061	Type III restriction enzyme res subunit
EPB59_RS05110	COG1187	pseudouridine synthase activity
EPB59_RS05115	COG2814	Major facilitator Superfamily
EPB59_RS05125	COG0702	epimerase
EPB59_RS05130	COG0534	Mate efflux family protein
EPB59_RS05135	COG4181	ATPase activity
EPB59_RS05140	COG0577	efflux transmembrane transporter activity
EPB59_RS05150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB59_RS05160	COG1748	Saccharopine dehydrogenase
EPB59_RS05175	COG1538	Outer membrane efflux protein
EPB59_RS05210	COG0583	DNA-binding transcription factor activity
EPB59_RS05220	COG1451	nucleotide metabolic process
EPB59_RS05235	COG3063	Type IV pilus biogenesis stability protein PilW
EPB59_RS05240	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EPB59_RS05260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB59_RS05275	COG3290	protein histidine kinase activity
EPB59_RS05280	COG4565	transcriptional regulatory protein
EPB59_RS05290	COG0784	Response regulator, receiver
EPB59_RS05290	COG0835	chemotaxis
EPB59_RS05330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EPB59_RS05335	COG2017	converts alpha-aldose to the beta-anomer
EPB59_RS05340	COG3706	GGDEF domain
EPB59_RS05345	COG2200	EAL domain
EPB59_RS05345	COG2199	diguanylate cyclase activity
EPB59_RS05360	COG3527	Alpha-acetolactate decarboxylase
EPB59_RS05375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPB59_RS05400	COG3097	Belongs to the UPF0267 family
EPB59_RS05425	COG1271	oxidase subunit
EPB59_RS05430	COG1294	oxidase, subunit
EPB59_RS05435	COG1136	(ABC) transporter
EPB59_RS05435	COG0577	efflux transmembrane transporter activity
EPB59_RS05440	COG1136	(ABC) transporter
EPB59_RS05440	COG0577	efflux transmembrane transporter activity
EPB59_RS05470	COG2723	6-phospho-beta-galactosidase activity
EPB59_RS05475	COG1609	Transcriptional regulator
EPB59_RS05480	COG0251	oxidation-reduction process
EPB59_RS05485	COG2731	YhcH YjgK YiaL family protein
EPB59_RS05490	COG0584	glycerophosphoryl diester phosphodiesterase
EPB59_RS05495	COG1349	DNA-binding transcription factor activity
EPB59_RS05500	COG3842	ATPase activity
EPB59_RS05505	COG0395	ABC-type sugar transport system, permease component
EPB59_RS05510	COG1175	transmembrane transport
EPB59_RS05515	COG1653	transport
EPB59_RS05525	COG0811	peptide transport
EPB59_RS05530	COG0811	peptide transport
EPB59_RS05535	COG0848	biopolymer transport protein
EPB59_RS05555	COG0534	Mate efflux family protein
EPB59_RS05575	COG0791	NLP P60 protein
EPB59_RS05580	COG0840	transmembrane signaling receptor activity
EPB59_RS05590	COG3148	PFAM DTW domain containing protein
EPB59_RS05595	COG1940	carbohydrate kinase activity
EPB59_RS05605	COG0303	'Molybdopterin
EPB59_RS05610	COG0746	molybdenum cofactor guanylyltransferase activity
EPB59_RS05615	COG3842	ATPase activity
EPB59_RS05620	COG4662	Binding-protein-dependent transport system inner membrane component
EPB59_RS05635	COG3852	Histidine kinase
EPB59_RS05640	COG0488	(ABC) transporter
EPB59_RS05645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPB59_RS05675	COG3383	formate dehydrogenase (NAD+) activity
EPB59_RS05675	COG0243	molybdopterin cofactor binding
EPB59_RS05680	COG0437	4 iron, 4 sulfur cluster binding
EPB59_RS05695	COG0004	ammonium transporteR
EPB59_RS05700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPB59_RS05705	COG1666	GTP binding
EPB59_RS05725	COG2996	Protein conserved in bacteria
EPB59_RS05735	COG3008	intermembrane lipid transfer
EPB59_RS05740	COG2995	paraquat-inducible protein a
EPB59_RS05745	COG1132	(ABC) transporter
EPB59_RS05750	COG1956	GAF domain-containing protein
EPB59_RS05755	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EPB59_RS05770	COG0308	aminopeptidase N
EPB59_RS05780	COG2902	Dehydrogenase
EPB59_RS05785	COG0167	dihydroorotate dehydrogenase activity
EPB59_RS05795	COG0116	Belongs to the methyltransferase superfamily
EPB59_RS05795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB59_RS05805	COG0488	(ABC) transporter
EPB59_RS05820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB59_RS05825	COG1067	ATP-dependent peptidase activity
EPB59_RS05830	COG3120	sequence-specific DNA binding
EPB59_RS05845	COG2205	protein histidine kinase activity
EPB59_RS05845	COG0784	Response regulator, receiver
EPB59_RS05860	COG3278	Belongs to the heme-copper respiratory oxidase family
EPB59_RS05875	COG2010	Cytochrome c
EPB59_RS05885	COG2217	Heavy metal translocating P-type atpase
EPB59_RS05900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB59_RS05905	COG0589	response to stress
EPB59_RS05910	COG0037	tRNA processing
EPB59_RS05930	COG3842	ATPase activity
EPB59_RS05935	COG1176	ABC-type spermidine putrescine transport system, permease component I
EPB59_RS05940	COG1177	transmembrane transport
EPB59_RS05965	COG1115	amino acid carrier protein
EPB59_RS05970	COG1280	lysine exporter protein (LysE YggA)
EPB59_RS05990	COG3501	Rhs element vgr protein
EPB59_RS06000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPB59_RS06010	COG2814	Major facilitator Superfamily
EPB59_RS06015	COG1566	PFAM secretion protein HlyD family protein
EPB59_RS06020	COG1538	Outer membrane efflux protein
EPB59_RS06030	COG0513	Belongs to the DEAD box helicase family
EPB59_RS06035	COG0840	transmembrane signaling receptor activity
EPB59_RS06050	COG0477	Major facilitator Superfamily
EPB59_RS06055	COG0583	DNA-binding transcription factor activity
EPB59_RS06065	COG0095	Lipoate-protein ligase
EPB59_RS06070	COG0443	Heat shock 70 kDa protein
EPB59_RS06075	COG0402	S-adenosylhomocysteine deaminase activity
EPB59_RS06085	COG0840	transmembrane signaling receptor activity
EPB59_RS06100	COG1643	Atp-dependent helicase
EPB59_RS06125	COG3706	GGDEF domain
EPB59_RS06135	COG0443	Heat shock 70 kDa protein
EPB59_RS06140	COG0443	Heat shock 70 kDa protein
EPB59_RS06145	COG3706	GGDEF domain
EPB59_RS06160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPB59_RS06170	COG2199	diguanylate cyclase activity
EPB59_RS06175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPB59_RS06180	COG0602	queuosine metabolic process
EPB59_RS06185	COG0561	phosphatase activity
EPB59_RS06195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB59_RS06200	COG4597	amino acid ABC transporter
EPB59_RS06205	COG0765	amino acid transport
EPB59_RS06210	COG1126	abc transporter atp-binding protein
EPB59_RS06215	COG0670	Belongs to the BI1 family
EPB59_RS06220	COG2920	part of a sulfur-relay system
EPB59_RS06225	COG1254	Belongs to the acylphosphatase family
EPB59_RS06235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB59_RS06240	COG3706	GGDEF domain
EPB59_RS06255	COG3437	response regulator, receiver
EPB59_RS06260	COG0625	glutathione transferase activity
EPB59_RS06270	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EPB59_RS06280	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB59_RS06310	COG0372	Belongs to the citrate synthase family
EPB59_RS06315	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EPB59_RS06355	COG1129	ABC transporter
EPB59_RS06380	COG0745	RESPONSE REGULATOR receiver
EPB59_RS06385	COG2205	protein histidine kinase activity
EPB59_RS06395	COG3713	MltA-interacting MipA family protein
EPB59_RS06400	COG2990	Protein conserved in bacteria
EPB59_RS06410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB59_RS06410	COG4191	Histidine kinase
EPB59_RS06415	COG0471	metal ion transport
EPB59_RS06425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB59_RS06445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB59_RS06455	COG3768	UPF0283 membrane protein
EPB59_RS06460	COG3106	COG3106 Predicted ATPase
EPB59_RS06475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB59_RS06480	COG0494	nUDIX hydrolase
EPB59_RS06485	COG0814	amino acid
EPB59_RS06490	COG1760	l-serine dehydratase
EPB59_RS06495	COG0720	synthase
EPB59_RS06500	COG0840	transmembrane signaling receptor activity
EPB59_RS06505	COG0017	Asparaginyl-tRNA synthetase
EPB59_RS06510	COG0351	phosphomethylpyrimidine kinase
EPB59_RS06515	COG0110	maltose O-acetyltransferase activity
EPB59_RS06520	COG1448	Aminotransferase
EPB59_RS06535	COG0840	transmembrane signaling receptor activity
EPB59_RS06540	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EPB59_RS06545	COG2943	transferase activity, transferring hexosyl groups
EPB59_RS06550	COG1609	Transcriptional regulator
EPB59_RS06555	COG3394	polysaccharide catabolic process
EPB59_RS06560	COG1486	melibiose metabolic process
EPB59_RS06565	COG1447	Phosphotransferase system cellobiose-specific component IIA
EPB59_RS06575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPB59_RS06580	COG0726	polysaccharide deacetylase
EPB59_RS06585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB59_RS06590	COG1846	Transcriptional regulator
EPB59_RS06615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EPB59_RS06630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB59_RS06635	COG3108	Peptidase M15
EPB59_RS06665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB59_RS06685	COG1054	Belongs to the UPF0176 family
EPB59_RS06690	COG1278	Cold shock
EPB59_RS06700	COG3088	subunit of a heme lyase
EPB59_RS06700	COG4235	cytochrome complex assembly
EPB59_RS06710	COG1138	Cytochrome C-type biogenesis protein
EPB59_RS06715	COG3301	Polysulphide reductase, NrfD
EPB59_RS06720	COG0437	4 iron, 4 sulfur cluster binding
EPB59_RS06730	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EPB59_RS06745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB59_RS06750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB59_RS06800	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EPB59_RS06805	COG4139	cobalamin transport
EPB59_RS06810	COG2988	succinylglutamate desuccinylase activity
EPB59_RS06825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EPB59_RS06830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EPB59_RS06835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB59_RS06840	COG1823	symporter activity
EPB59_RS06845	COG2925	Exonuclease
EPB59_RS06850	COG1380	Effector of murein hydrolase LrgA
EPB59_RS06855	COG1346	cytolysis
EPB59_RS06890	COG0776	regulation of translation
EPB59_RS06895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB59_RS06895	COG0072	phenylalanine-tRNA ligase activity
EPB59_RS06900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPB59_RS06940	COG0322	excinuclease ABC activity
EPB59_RS06945	COG2197	response regulator
EPB59_RS06950	COG0417	DNA replication proofreading
EPB59_RS06955	COG5001	Diguanylate cyclase
EPB59_RS06965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPB59_RS06970	COG3099	Belongs to the UPF0263 family
EPB59_RS06980	COG1228	amidohydrolase
EPB59_RS06985	COG0010	Belongs to the arginase family
EPB59_RS06990	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EPB59_RS06995	COG2986	histidine ammonia-lyase
EPB59_RS07015	COG0247	lactate metabolic process
EPB59_RS07015	COG0277	FAD linked oxidase domain protein
EPB59_RS07030	COG2885	chlorophyll binding
EPB59_RS07050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPB59_RS07060	COG0281	malic enzyme
EPB59_RS07070	COG2949	membrane
EPB59_RS07075	COG3706	GGDEF domain
EPB59_RS07090	COG0492	ferredoxin-NADP+ reductase activity
EPB59_RS07095	COG4988	ABC transporter
EPB59_RS07100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPB59_RS07105	COG1187	pseudouridine synthase activity
EPB59_RS07110	COG0009	L-threonylcarbamoyladenylate synthase
EPB59_RS07115	COG0613	PHP domain protein
EPB59_RS07125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB59_RS07130	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB59_RS07135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPB59_RS07140	COG0134	indole-3-glycerol-phosphate synthase activity
EPB59_RS07140	COG0135	phosphoribosylanthranilate isomerase activity
EPB59_RS07145	COG0133	tryptophan synthase activity
EPB59_RS07150	COG0159	tryptophan synthase activity
EPB59_RS07160	COG1435	thymidine kinase activity
EPB59_RS07165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EPB59_RS07170	COG1801	Protein of unknown function DUF72
EPB59_RS07175	COG4106	trans-aconitate 2-methyltransferase activity
EPB59_RS07180	COG0500	methyltransferase
EPB59_RS07185	COG4067	protein conserved in archaea
EPB59_RS07185	COG0189	ligase activity
EPB59_RS07200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EPB59_RS07210	COG3852	Histidine kinase
EPB59_RS07225	COG3070	regulator of competence-specific genes
EPB59_RS07235	COG2431	L-lysine efflux transmembrane transporter activity
EPB59_RS07245	COG0076	glutamate decarboxylase activity
EPB59_RS07250	COG1737	Transcriptional regulator
EPB59_RS07255	COG1012	belongs to the aldehyde dehydrogenase family
EPB59_RS07255	COG1454	alcohol dehydrogenase
EPB59_RS07260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB59_RS07265	COG3273	potassium ion transport
EPB59_RS07265	COG2985	domain, Protein
EPB59_RS07270	COG0542	response to heat
EPB59_RS07275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPB59_RS07280	COG1278	Cold shock
EPB59_RS07290	COG1187	pseudouridine synthase activity
EPB59_RS07295	COG0140	phosphoribosyl-ATP diphosphatase activity
EPB59_RS07295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPB59_RS07305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPB59_RS07310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPB59_RS07315	COG0131	Imidazoleglycerol-phosphate dehydratase
EPB59_RS07315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB59_RS07320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EPB59_RS07325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPB59_RS07330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPB59_RS07335	COG1757	Na H antiporter
EPB59_RS07340	COG2916	Histone family protein nucleoid-structuring protein H-NS
EPB59_RS07345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB59_RS07350	COG0482	sulfurtransferase activity
EPB59_RS07355	COG2915	High frequency lysogenization protein hflD homolog
EPB59_RS07360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPB59_RS07370	COG2268	Band 7 protein
EPB59_RS07380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPB59_RS07395	COG0300	oxidoreductase activity
EPB59_RS07405	COG0501	Belongs to the peptidase M48B family
EPB59_RS07415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EPB59_RS07420	COG2226	methyltransferase
EPB59_RS07425	COG0156	8-amino-7-oxononanoate synthase activity
EPB59_RS07435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPB59_RS07440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPB59_RS07445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPB59_RS07450	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EPB59_RS07455	COG0653	protein targeting
EPB59_RS07460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB59_RS07465	COG2203	Gaf domain
EPB59_RS07465	COG2199	diguanylate cyclase activity
EPB59_RS07475	COG4120	Belongs to the binding-protein-dependent transport system permease family
EPB59_RS07485	COG4628	conserved protein (DUF2132)
EPB59_RS07490	COG3092	negative regulation of chromosome organization
EPB59_RS07495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB59_RS07500	COG0280	phosphate acetyltransferase
EPB59_RS07500	COG0857	belongs to the CobB CobQ family
EPB59_RS07505	COG0435	Glutathione S-transferase
EPB59_RS07510	COG4608	Belongs to the ABC transporter superfamily
EPB59_RS07520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB59_RS07525	COG0601	transmembrane transport
EPB59_RS07540	COG4191	Histidine kinase
EPB59_RS07545	COG2204	response regulator
EPB59_RS07550	COG3300	MHYT domain
EPB59_RS07550	COG5001	Diguanylate cyclase
EPB59_RS07560	COG0784	Response regulator, receiver
EPB59_RS07560	COG4191	Histidine kinase
EPB59_RS07570	COG2201	protein-glutamate methylesterase activity
EPB59_RS07585	COG0009	L-threonylcarbamoyladenylate synthase
EPB59_RS07605	COG1881	PFAM PEBP family protein
EPB59_RS07630	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB59_RS07635	COG3716	PTS system mannose fructose sorbose family IID component
EPB59_RS07645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB59_RS07650	COG2222	sugar isomerase
EPB59_RS07660	COG1349	DNA-binding transcription factor activity
EPB59_RS07665	COG1349	DNA-binding transcription factor activity
EPB59_RS07680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB59_RS07685	COG0640	Transcriptional regulator
EPB59_RS07690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPB59_RS07695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPB59_RS07780	COG1396	sequence-specific DNA binding
EPB59_RS07805	COG3300	MHYT domain
EPB59_RS07805	COG5001	Diguanylate cyclase
EPB59_RS07825	COG1946	Acyl-CoA thioesterase
EPB59_RS07830	COG1522	sequence-specific DNA binding
EPB59_RS07840	COG0616	signal peptide processing
EPB59_RS07845	COG1028	Short-chain dehydrogenase reductase Sdr
EPB59_RS07850	COG2983	Belongs to the UPF0260 family
EPB59_RS07860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPB59_RS07865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EPB59_RS07870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPB59_RS07875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPB59_RS07880	COG2832	Protein of unknown function (DUF454)
EPB59_RS07890	COG0745	RESPONSE REGULATOR receiver
EPB59_RS07895	COG0583	DNA-binding transcription factor activity
EPB59_RS07900	COG0778	Nitroreductase
EPB59_RS07905	COG1024	Enoyl-CoA hydratase
EPB59_RS07905	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPB59_RS07910	COG0183	Belongs to the thiolase family
EPB59_RS07925	COG2067	long-chain fatty acid transport protein
EPB59_RS07930	COG2067	long-chain fatty acid transport protein
EPB59_RS07935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPB59_RS07940	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EPB59_RS07945	COG2982	Protein involved in outer membrane biogenesis
EPB59_RS07950	COG0572	uridine kinase
EPB59_RS07955	COG0489	protein tyrosine kinase activity
EPB59_RS07960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB59_RS07960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB59_RS07975	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EPB59_RS07985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EPB59_RS07985	COG0617	tRNA 3'-terminal CCA addition
EPB59_RS07985	COG0517	IMP dehydrogenase activity
EPB59_RS07990	COG2199	diguanylate cyclase activity
EPB59_RS07995	COG0314	molybdopterin synthase activity
EPB59_RS08000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EPB59_RS08005	COG0315	cyclic pyranopterin monophosphate synthase activity
EPB59_RS08010	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPB59_RS08015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPB59_RS08020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EPB59_RS08025	COG2198	Histidine kinase
EPB59_RS08030	COG2204	response regulator
EPB59_RS08035	COG0556	nucleotide-excision repair
EPB59_RS08045	COG4657	Part of a membrane complex involved in electron transport
EPB59_RS08050	COG2878	Part of a membrane complex involved in electron transport
EPB59_RS08055	COG4656	Part of a membrane complex involved in electron transport
EPB59_RS08060	COG4658	electron transport chain
EPB59_RS08070	COG4660	Part of a membrane complex involved in electron transport
EPB59_RS08075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPB59_RS08080	COG0346	lactoylglutathione lyase activity
EPB59_RS08090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPB59_RS08095	COG2056	Na+-H+ antiporter family
EPB59_RS08100	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPB59_RS08105	COG1286	toxin biosynthetic process
EPB59_RS08110	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EPB59_RS08115	COG0285	dihydrofolate synthase activity
EPB59_RS08120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPB59_RS08125	COG0101	tRNA pseudouridine synthase activity
EPB59_RS08140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB59_RS08140	COG1263	PTS System
EPB59_RS08140	COG2190	(PTS) system
EPB59_RS08145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPB59_RS08150	COG1846	Transcriptional regulator
EPB59_RS08150	COG1940	carbohydrate kinase activity
EPB59_RS08155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB59_RS08155	COG4651	solute:proton antiporter activity
EPB59_RS08160	COG0367	asparagine synthase
EPB59_RS08165	COG0250	Participates in transcription elongation, termination and antitermination
EPB59_RS08170	COG3104	oligopeptide transport
EPB59_RS08175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPB59_RS08180	COG0563	adenylate kinase activity
EPB59_RS08185	COG0326	Molecular chaperone. Has ATPase activity
EPB59_RS08190	COG3710	Transcriptional regulator
EPB59_RS08205	COG0622	Phosphoesterase
EPB59_RS08210	COG1090	epimerase
EPB59_RS08215	COG0300	oxidoreductase activity
EPB59_RS08225	COG3118	belongs to the thioredoxin family
EPB59_RS08230	COG0330	HflC and HflK could
EPB59_RS08235	COG1585	Membrane protein implicated in regulation of membrane protease activity
EPB59_RS08240	COG0789	Transcriptional regulator
EPB59_RS08255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPB59_RS08260	COG3115	cell septum assembly
EPB59_RS08265	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EPB59_RS08270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPB59_RS08280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB59_RS08290	COG2190	(PTS) system
EPB59_RS08295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB59_RS08300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPB59_RS08305	COG1702	phosphate starvation-inducible protein PhoH
EPB59_RS08310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPB59_RS08315	COG4535	Mg2 and Co2 transporter CorC
EPB59_RS08320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPB59_RS08325	COG2888	peptidyl-tyrosine sulfation
EPB59_RS08330	COG0495	leucyl-tRNA aminoacylation
EPB59_RS08335	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EPB59_RS08340	COG1466	dna polymerase III delta subunit
EPB59_RS08345	COG0799	negative regulation of ribosome biogenesis
EPB59_RS08350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EPB59_RS08355	COG0768	penicillin binding
EPB59_RS08360	COG0772	Belongs to the SEDS family
EPB59_RS08365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPB59_RS08370	COG1686	Belongs to the peptidase S11 family
EPB59_RS08375	COG2921	Belongs to the UPF0250 family
EPB59_RS08380	COG0321	lipoyl(octanoyl) transferase activity
EPB59_RS08385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPB59_RS08395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB59_RS08420	COG1596	polysaccharide export
EPB59_RS08430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB59_RS08460	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EPB59_RS08470	COG0297	glycogen (starch) synthase activity
EPB59_RS08470	COG0438	transferase activity, transferring glycosyl groups
EPB59_RS08500	COG0438	transferase activity, transferring glycosyl groups
EPB59_RS08510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EPB59_RS08515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPB59_RS08520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPB59_RS08525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB59_RS08530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB59_RS08565	COG2205	protein histidine kinase activity
EPB59_RS08570	COG0745	RESPONSE REGULATOR receiver
EPB59_RS08575	COG0366	Alpha amylase catalytic
EPB59_RS08580	COG1263	PTS System
EPB59_RS08580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB59_RS08585	COG1609	Transcriptional regulator
EPB59_RS08590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB59_RS08595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPB59_RS08600	COG2011	ABC-type metal ion transport system permease component
EPB59_RS08605	COG1464	Belongs to the NlpA lipoprotein family
EPB59_RS08610	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EPB59_RS08620	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB59_RS08620	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB59_RS08635	COG1611	Belongs to the LOG family
EPB59_RS08640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB59_RS08645	COG2363	Small membrane protein
EPB59_RS08650	COG0583	DNA-binding transcription factor activity
EPB59_RS08655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB59_RS08655	COG0301	tRNA thio-modification
EPB59_RS08665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB59_RS08670	COG1722	exodeoxyribonuclease VII activity
EPB59_RS08675	COG0142	geranyltranstransferase activity
EPB59_RS08680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPB59_RS08685	COG0564	pseudouridine synthase activity
EPB59_RS08715	COG1671	Belongs to the UPF0178 family
EPB59_RS08720	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB59_RS08725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPB59_RS08730	COG0254	rRNA binding
EPB59_RS08735	COG1720	tRNA m6t6A37 methyltransferase activity
EPB59_RS08740	COG0442	prolyl-tRNA aminoacylation
EPB59_RS08760	COG0047	phosphoribosylformylglycinamidine synthase activity
EPB59_RS08760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPB59_RS08765	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EPB59_RS08775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB59_RS08795	COG4968	Prepilin-type N-terminal cleavage methylation domain
EPB59_RS08805	COG0484	heat shock protein binding
EPB59_RS08810	COG0443	Heat shock 70 kDa protein
EPB59_RS08815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPB59_RS08820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPB59_RS08825	COG0497	DNA recombination
EPB59_RS08830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB59_RS08835	COG2914	Belongs to the UPF0125 (RnfH) family
EPB59_RS08840	COG2867	negative regulation of translational initiation
EPB59_RS08845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EPB59_RS08855	COG1061	Type III restriction enzyme res subunit
EPB59_RS08870	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EPB59_RS08875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EPB59_RS08880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB59_RS08900	COG3051	citrate lyase alpha subunit
EPB59_RS08905	COG2301	Belongs to the HpcH HpaI aldolase family
EPB59_RS08910	COG3052	prosthetic group binding
EPB59_RS08915	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EPB59_RS08925	COG3630	sodium ion export across plasma membrane
EPB59_RS08930	COG5016	pyruvate
EPB59_RS08930	COG0511	ligase activity, forming carbon-carbon bonds
EPB59_RS08935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPB59_RS08945	COG4565	transcriptional regulatory protein
EPB59_RS08960	COG0583	DNA-binding transcription factor activity
EPB59_RS08970	COG1115	amino acid carrier protein
EPB59_RS08975	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EPB59_RS08980	COG0583	DNA-binding transcription factor activity
EPB59_RS08985	COG1584	GPR1 FUN34 yaaH family protein
EPB59_RS08995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPB59_RS08995	COG0519	Catalyzes the synthesis of GMP from XMP
EPB59_RS09000	COG0517	IMP dehydrogenase activity
EPB59_RS09000	COG0516	GMP reductase activity
EPB59_RS09005	COG1570	exodeoxyribonuclease VII activity
EPB59_RS09015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPB59_RS09020	COG1160	GTP binding
EPB59_RS09025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB59_RS09030	COG2976	Protein conserved in bacteria
EPB59_RS09035	COG0124	histidyl-tRNA synthetase
EPB59_RS09040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPB59_RS09045	COG1426	Protein conserved in bacteria
EPB59_RS09050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EPB59_RS09055	COG0105	UTP biosynthetic process
EPB59_RS09060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB59_RS09065	COG2975	iron-sulfur cluster assembly
EPB59_RS09070	COG0633	Ferredoxin
EPB59_RS09080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB59_RS09085	COG0316	Belongs to the HesB IscA family
EPB59_RS09090	COG0822	iron-sulfur transferase activity
EPB59_RS09100	COG1959	2 iron, 2 sulfur cluster binding
EPB59_RS09105	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EPB59_RS09110	COG0483	inositol monophosphate 1-phosphatase activity
EPB59_RS09115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB59_RS09120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB59_RS09125	COG1862	Preprotein translocase
EPB59_RS09135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPB59_RS09140	COG0517	IMP dehydrogenase activity
EPB59_RS09150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPB59_RS09155	COG0583	DNA-binding transcription factor activity
EPB59_RS09160	COG0450	alkyl hydroperoxide reductase
EPB59_RS09165	COG3142	Participates in the control of copper homeostasis
EPB59_RS09180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB59_RS09185	COG0581	inorganic phosphate transmembrane transporter activity
EPB59_RS09190	COG0573	inorganic phosphate transmembrane transporter activity
EPB59_RS09195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPB59_RS09200	COG0248	Ppx GppA phosphatase
EPB59_RS09210	COG5002	protein histidine kinase activity
EPB59_RS09215	COG0745	RESPONSE REGULATOR receiver
EPB59_RS09225	COG0826	peptidase U32
EPB59_RS09230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB59_RS09275	COG0542	response to heat
EPB59_RS09290	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB59_RS09295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB59_RS09300	COG0077	Prephenate dehydratase
EPB59_RS09300	COG1605	Chorismate mutase
EPB59_RS09305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EPB59_RS09310	COG5001	Diguanylate cyclase
EPB59_RS09320	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EPB59_RS09330	COG0488	(ABC) transporter
EPB59_RS09340	COG0287	Prephenate dehydrogenase
EPB59_RS09340	COG1605	Chorismate mutase
EPB59_RS09345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB59_RS09350	COG3275	phosphorelay sensor kinase activity
EPB59_RS09355	COG3279	Response regulator of the LytR AlgR family
EPB59_RS09365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPB59_RS09370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPB59_RS09380	COG1966	Carbon starvation protein
EPB59_RS09385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPB59_RS09390	COG1047	Peptidyl-prolyl cis-trans
EPB59_RS09395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EPB59_RS09405	COG0196	riboflavin kinase activity
EPB59_RS09410	COG0728	peptidoglycan biosynthetic process
EPB59_RS09415	COG0268	Binds directly to 16S ribosomal RNA
EPB59_RS09420	COG0640	Transcriptional regulator
EPB59_RS09425	COG0583	DNA-binding transcription factor activity
EPB59_RS09430	COG1283	sodium-dependent phosphate transmembrane transporter activity
EPB59_RS09435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPB59_RS09440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPB59_RS09445	COG0730	response to heat
EPB59_RS09450	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EPB59_RS09455	COG0494	nUDIX hydrolase
EPB59_RS09460	COG3066	DNA modification
EPB59_RS09465	COG0667	Aldo Keto reductase
EPB59_RS09475	COG2204	response regulator
EPB59_RS09480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPB59_RS09500	COG0513	Belongs to the DEAD box helicase family
EPB59_RS09525	COG3153	acetyltransferase
EPB59_RS09530	COG3154	lipid carrier protein
EPB59_RS09540	COG0826	peptidase U32
EPB59_RS09545	COG0826	peptidase U32
EPB59_RS09570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPB59_RS09580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPB59_RS09585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPB59_RS09590	COG0195	Participates in both transcription termination and antitermination
EPB59_RS09595	COG0779	Required for maturation of 30S ribosomal subunits
EPB59_RS09610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB59_RS09620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPB59_RS09625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPB59_RS09630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EPB59_RS09635	COG1534	Rna-binding protein
EPB59_RS09640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB59_RS09645	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB59_RS09650	COG2027	D-alanyl-D-alanine carboxypeptidase
EPB59_RS09655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB59_RS09660	COG0739	heme binding
EPB59_RS09675	COG0316	Belongs to the HesB IscA family
EPB59_RS09680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPB59_RS09690	COG0628	permease
EPB59_RS09695	COG2813	Specifically methylates the guanine in position
EPB59_RS09700	COG0784	Response regulator, receiver
EPB59_RS09700	COG2205	protein histidine kinase activity
EPB59_RS09705	COG0747	negative chemotaxis
EPB59_RS09715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB59_RS09720	COG0444	Belongs to the ABC transporter superfamily
EPB59_RS09725	COG4608	Belongs to the ABC transporter superfamily
EPB59_RS09735	COG2971	BadF BadG BcrA BcrD
EPB59_RS09755	COG3842	ATPase activity
EPB59_RS09765	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB59_RS09770	COG0004	ammonium transporteR
EPB59_RS09775	COG0347	Belongs to the P(II) protein family
EPB59_RS09780	COG3112	Uncharacterised protein family (UPF0231)
EPB59_RS09795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB59_RS09800	COG1643	Atp-dependent helicase
EPB59_RS09810	COG1489	DNA binding
EPB59_RS09815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPB59_RS09820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB59_RS09830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB59_RS09835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPB59_RS09840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPB59_RS09845	COG0842	Transport permease protein
EPB59_RS09850	COG1131	(ABC) transporter
EPB59_RS09855	COG0659	secondary active sulfate transmembrane transporter activity
EPB59_RS09860	COG0288	reversible hydration of carbon dioxide
EPB59_RS09875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPB59_RS09880	COG3107	peptidoglycan biosynthetic process
EPB59_RS09885	COG0792	nuclease activity
EPB59_RS09890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB59_RS09895	COG2823	Periplasmic or secreted lipoprotein
EPB59_RS09900	COG2969	positive regulation of protein catabolic process
EPB59_RS09905	COG0625	glutathione transferase activity
EPB59_RS09910	COG2857	Cytochrome c1
EPB59_RS09915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EPB59_RS09920	COG0723	plastoquinol--plastocyanin reductase activity
EPB59_RS09925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPB59_RS09930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPB59_RS09935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPB59_RS09945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPB59_RS09950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPB59_RS09955	COG0335	large ribosomal subunit rRNA binding
EPB59_RS09960	COG0336	Belongs to the RNA methyltransferase TrmD family
EPB59_RS09965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPB59_RS09970	COG0228	four-way junction DNA binding
EPB59_RS09975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPB59_RS09980	COG4137	Cytochrome C assembly protein
EPB59_RS09985	COG4536	flavin adenine dinucleotide binding
EPB59_RS09990	COG1854	S-ribosylhomocysteine lyase activity
EPB59_RS09995	COG2918	glutathione biosynthetic process
EPB59_RS10000	COG0612	Peptidase, M16
EPB59_RS10005	COG1238	metal cluster binding
EPB59_RS10015	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPB59_RS10020	COG0511	ligase activity, forming carbon-carbon bonds
EPB59_RS10020	COG5016	pyruvate
EPB59_RS10025	COG3630	sodium ion export across plasma membrane
EPB59_RS10070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EPB59_RS10075	COG0527	aspartate kinase activity
EPB59_RS10080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPB59_RS10085	COG2137	regulation of response to DNA damage stimulus
EPB59_RS10090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPB59_RS10095	COG1546	Belongs to the CinA family
EPB59_RS10105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EPB59_RS10110	COG4208	sulfate ABC transporter
EPB59_RS10130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPB59_RS10135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPB59_RS10145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPB59_RS10150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPB59_RS10155	COG0585	pseudouridine synthase activity
EPB59_RS10160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EPB59_RS10170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EPB59_RS10175	COG1968	undecaprenyl-diphosphatase activity
EPB59_RS10180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB59_RS10185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPB59_RS10190	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPB59_RS10200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPB59_RS10205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPB59_RS10210	COG1610	YqeY-like protein
EPB59_RS10215	COG0358	DNA primase activity
EPB59_RS10235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EPB59_RS10325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPB59_RS10330	COG1349	DNA-binding transcription factor activity
EPB59_RS10350	COG1279	arginine transmembrane transporter activity
EPB59_RS10355	COG0668	transmembrane transport
EPB59_RS10360	COG0191	fructose-bisphosphate aldolase activity
EPB59_RS10365	COG0126	phosphoglycerate kinase activity
EPB59_RS10370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB59_RS10375	COG4771	TonB-dependent receptor
EPB59_RS10380	COG0583	DNA-binding transcription factor activity
EPB59_RS10385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB59_RS10390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPB59_RS10400	COG2356	endonuclease I
EPB59_RS10405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPB59_RS10410	COG0189	ligase activity
EPB59_RS10415	COG1678	Uncharacterized ACR, COG1678
EPB59_RS10420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPB59_RS10425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB59_RS10445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPB59_RS10450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EPB59_RS10455	COG0762	integral membrane protein
EPB59_RS10470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPB59_RS10475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPB59_RS10485	COG2066	Belongs to the glutaminase family
EPB59_RS10490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPB59_RS10495	COG1194	a g-specific adenine glycosylase
EPB59_RS10500	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EPB59_RS10505	COG0741	lytic transglycosylase activity
EPB59_RS10560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB59_RS10565	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EPB59_RS10570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB59_RS10575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPB59_RS10580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPB59_RS10585	COG2967	ApaG domain
EPB59_RS10590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPB59_RS10600	COG3610	response to peptide
EPB59_RS10610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPB59_RS10615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EPB59_RS10620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPB59_RS10625	COG0142	geranyltranstransferase activity
EPB59_RS10630	COG0531	amino acid
EPB59_RS10635	COG0039	L-malate dehydrogenase activity
EPB59_RS10640	COG1438	arginine binding
EPB59_RS10655	COG0589	response to stress
EPB59_RS10680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB59_RS10690	COG0312	modulator of DNA gyrase
EPB59_RS10695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB59_RS10700	COG3164	Protein of unknown function
EPB59_RS10710	COG0424	maF-like protein
EPB59_RS10715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPB59_RS10720	COG1792	Involved in formation and maintenance of cell shape
EPB59_RS10725	COG1077	Cell shape determining protein MreB Mrl
EPB59_RS10760	COG2165	general secretion pathway protein
EPB59_RS10770	COG1459	type II secretion system
EPB59_RS10775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB59_RS10785	COG3267	Type II secretory pathway component ExeA
EPB59_RS10785	COG3409	Peptidoglycan-binding domain 1 protein
EPB59_RS10790	COG1450	Type ii and iii secretion system protein
EPB59_RS10810	COG2200	EAL domain
EPB59_RS10810	COG2199	diguanylate cyclase activity
EPB59_RS10830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPB59_RS10840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPB59_RS10845	COG0527	aspartate kinase activity
EPB59_RS10850	COG0646	methionine synthase
EPB59_RS10850	COG1410	methionine synthase
EPB59_RS10920	COG0175	sulfate reduction
EPB59_RS10930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB59_RS10955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB59_RS10960	COG0735	belongs to the Fur family
EPB59_RS10975	COG0166	Belongs to the GPI family
EPB59_RS10985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB59_RS11000	COG0359	binds to the 23S rRNA
EPB59_RS11005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EPB59_RS11010	COG2965	DNA replication, synthesis of RNA primer
EPB59_RS11015	COG0360	Binds together with S18 to 16S ribosomal RNA
EPB59_RS11025	COG2906	2 iron, 2 sulfur cluster binding
EPB59_RS11030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPB59_RS11035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB59_RS11040	COG0049	tRNA binding
EPB59_RS11055	COG2923	Belongs to the DsrF TusC family
EPB59_RS11060	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EPB59_RS11065	COG2964	Protein conserved in bacteria
EPB59_RS11070	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB59_RS11080	COG2900	Belongs to the SlyX family
EPB59_RS11085	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EPB59_RS11090	COG0330	HflC and HflK could
EPB59_RS11095	COG0330	HflC and HflK could
EPB59_RS11100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPB59_RS11105	COG1923	regulation of RNA biosynthetic process
EPB59_RS11110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPB59_RS11115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPB59_RS11125	COG0802	atpase or kinase
EPB59_RS11130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPB59_RS11165	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EPB59_RS11170	COG1162	GTPase activity
EPB59_RS11175	COG0688	phosphatidylethanolamine metabolic process
EPB59_RS11180	COG0471	metal ion transport
EPB59_RS11190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPB59_RS11195	COG4942	peptidase
EPB59_RS11210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPB59_RS11215	COG2816	NAD+ diphosphatase activity
EPB59_RS11220	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EPB59_RS11225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EPB59_RS11230	COG0085	RNA polymerase activity
EPB59_RS11235	COG0222	ribosome binding
EPB59_RS11240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPB59_RS11250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EPB59_RS11255	COG0250	Participates in transcription elongation, termination and antitermination
EPB59_RS11260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB59_RS11265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPB59_RS11290	COG1072	(Pantothenic acid kinase))
EPB59_RS11300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPB59_RS11310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB59_RS11350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EPB59_RS11365	COG3118	belongs to the thioredoxin family
EPB59_RS11370	COG0513	Belongs to the DEAD box helicase family
EPB59_RS11375	COG0248	Ppx GppA phosphatase
EPB59_RS11385	COG2814	Major facilitator Superfamily
EPB59_RS11400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB59_RS11405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPB59_RS11410	COG0511	ligase activity, forming carbon-carbon bonds
EPB59_RS11415	COG0439	Biotin carboxylase
EPB59_RS11425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB59_RS11430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EPB59_RS11470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EPB59_RS11480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPB59_RS11510	COG1609	Transcriptional regulator
EPB59_RS11515	COG0129	dihydroxy-acid dehydratase activity
EPB59_RS11520	COG3265	gluconokinase activity
EPB59_RS11525	COG2610	gluconate transmembrane transporter activity
EPB59_RS11530	COG0800	Aldolase
EPB59_RS11535	COG0840	transmembrane signaling receptor activity
EPB59_RS11540	COG1982	Orn Lys Arg decarboxylase major
EPB59_RS11545	COG0531	amino acid
EPB59_RS11550	COG3710	Transcriptional regulator
EPB59_RS11555	COG0789	Transcriptional regulator
EPB59_RS11570	COG0151	Belongs to the GarS family
EPB59_RS11580	COG0776	regulation of translation
EPB59_RS11585	COG1253	flavin adenine dinucleotide binding
EPB59_RS11590	COG3068	Protein conserved in bacteria
EPB59_RS11600	COG1573	uracil-dna glycosylase
EPB59_RS11605	COG0668	transmembrane transport
EPB59_RS11610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EPB59_RS11620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB59_RS11670	COG0367	asparagine synthase
EPB59_RS11680	COG5433	transposase activity
EPB59_RS11715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EPB59_RS11725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EPB59_RS11730	COG5433	transposase activity
EPB59_RS11735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPB59_RS11745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB59_RS11790	COG1519	Transferase
EPB59_RS11815	COG3642	lipopolysaccharide core region biosynthetic process
EPB59_RS11820	COG0859	PFAM glycosyl transferase family 9
EPB59_RS11825	COG0463	Glycosyl transferase, family 2
EPB59_RS11830	COG0859	PFAM glycosyl transferase family 9
EPB59_RS11835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPB59_RS11840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EPB59_RS11850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EPB59_RS11855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPB59_RS11860	COG2003	Belongs to the UPF0758 family
EPB59_RS11870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPB59_RS11875	COG1309	transcriptional regulator
EPB59_RS11880	COG1560	Kdo2-lipid A biosynthetic process
EPB59_RS11885	COG1560	Kdo2-lipid A biosynthetic process
EPB59_RS11890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPB59_RS11895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EPB59_RS11900	COG1561	YicC-like family, N-terminal region
EPB59_RS11905	COG2862	Uncharacterized protein family, UPF0114
EPB59_RS11910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB59_RS11910	COG1263	PTS System
EPB59_RS11915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPB59_RS11940	COG1120	ATPase activity
EPB59_RS11945	COG4774	siderophore transport
EPB59_RS11950	COG1132	(ABC) transporter
EPB59_RS11965	COG0514	ATP-dependent DNA helicase (RecQ)
EPB59_RS11970	COG2962	Rard protein
EPB59_RS11975	COG0405	Gamma-glutamyltransferase
EPB59_RS11985	COG1280	lysine exporter protein (LysE YggA)
EPB59_RS11990	COG0210	DNA helicase
EPB59_RS12000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPB59_RS12005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB59_RS12025	COG0784	Response regulator, receiver
EPB59_RS12025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB59_RS12035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB59_RS12045	COG0747	negative chemotaxis
EPB59_RS12090	COG1309	transcriptional regulator
EPB59_RS12095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB59_RS12100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB59_RS12105	COG2960	long-chain fatty acid transporting porin activity
EPB59_RS12110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPB59_RS12115	COG0583	DNA-binding transcription factor activity
EPB59_RS12185	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EPB59_RS12190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB59_RS12200	COG1024	Enoyl-CoA hydratase
EPB59_RS12200	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPB59_RS12205	COG0183	Belongs to the thiolase family
EPB59_RS12210	COG0583	DNA-binding transcription factor activity
EPB59_RS12225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPB59_RS12230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPB59_RS12235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPB59_RS12240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPB59_RS12245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPB59_RS12250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EPB59_RS12260	COG0356	it plays a direct role in the translocation of protons across the membrane
EPB59_RS12265	COG3312	ion transport
EPB59_RS12270	COG1475	DNA binding
EPB59_RS12275	COG1192	Involved in chromosome partitioning
EPB59_RS12280	COG0357	Ribosomal RNA small subunit methyltransferase G
EPB59_RS12285	COG0445	tRNA wobble uridine modification
EPB59_RS12290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB59_RS12295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EPB59_RS12300	COG0706	membrane insertase activity
EPB59_RS12310	COG0594	ribonuclease P activity
EPB59_RS12315	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EPB59_RS12320	COG1126	abc transporter atp-binding protein
EPB59_RS12335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPB59_RS12340	COG0592	DNA-directed DNA polymerase activity
EPB59_RS12345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPB59_RS12350	COG0187	DNA topoisomerase II activity
EPB59_RS12365	COG0071	Belongs to the small heat shock protein (HSP20) family
EPB59_RS12370	COG3977	Valine--pyruvate aminotransferase
EPB59_RS12375	COG0751	glycine-tRNA ligase activity
EPB59_RS12380	COG0752	glycyl-tRNA synthetase alpha subunit
EPB59_RS12385	COG2119	membrane
EPB59_RS12395	COG0425	Belongs to the sulfur carrier protein TusA family
EPB59_RS12405	COG0604	alcohol dehydrogenase
EPB59_RS12415	COG0129	dihydroxy-acid dehydratase activity
EPB59_RS12420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPB59_RS12435	COG0606	chelatase, subunit chli
EPB59_RS12440	COG0204	Acyl-transferase
EPB59_RS12445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB59_RS12450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPB59_RS12460	COG3084	Protein conserved in bacteria
EPB59_RS12470	COG4326	sporulation control protein
EPB59_RS12475	COG1272	protein, Hemolysin III
EPB59_RS12490	COG0569	domain protein
EPB59_RS12495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPB59_RS12495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB59_RS12505	COG0242	peptide deformylase activity
EPB59_RS12510	COG1652	LysM domain
EPB59_RS12515	COG0758	DNA mediated transformation
EPB59_RS12520	COG2922	Belongs to the Smg family
EPB59_RS12525	COG0551	DNA topoisomerase type I activity
EPB59_RS12530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPB59_RS12535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPB59_RS12540	COG0009	L-threonylcarbamoyladenylate synthase
EPB59_RS12550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPB59_RS12560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPB59_RS12600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EPB59_RS12605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EPB59_RS12610	COG0352	thiamine-phosphate diphosphorylase activity
EPB59_RS12620	COG2104	thiamine diphosphate biosynthetic process
EPB59_RS12625	COG2022	thiamine diphosphate biosynthetic process
EPB59_RS12630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPB59_RS12635	COG0006	proline dipeptidase activity
EPB59_RS12655	COG1522	sequence-specific DNA binding
EPB59_RS12660	COG5002	protein histidine kinase activity
EPB59_RS12660	COG5001	Diguanylate cyclase
EPB59_RS12680	COG0589	response to stress
EPB59_RS12685	COG1528	Iron-storage protein
EPB59_RS12695	COG2081	HI0933 family
EPB59_RS12725	COG0840	transmembrane signaling receptor activity
EPB59_RS12735	COG1322	Protein conserved in bacteria
EPB59_RS12740	COG2226	methyltransferase
EPB59_RS12755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB59_RS12760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB59_RS12765	COG0805	protein transport
EPB59_RS12770	COG0534	Mate efflux family protein
EPB59_RS12780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPB59_RS12790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPB59_RS12795	COG3161	chorismate lyase activity
EPB59_RS12805	COG1580	Controls the rotational direction of flagella during chemotaxis
EPB59_RS12815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB59_RS12820	COG0084	hydrolase, TatD family'
EPB59_RS12835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB59_RS12835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB59_RS12855	COG3078	GTPase activator activity
EPB59_RS12870	COG3071	HemY protein
EPB59_RS12875	COG2959	enzyme of heme biosynthesis
EPB59_RS12880	COG1587	Uroporphyrinogen-III synthase
EPB59_RS12885	COG0181	hydroxymethylbilane synthase activity
EPB59_RS12890	COG3072	Adenylate cyclase
EPB59_RS12895	COG1965	Belongs to the frataxin family
EPB59_RS12905	COG0019	diaminopimelate decarboxylase activity
EPB59_RS12910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EPB59_RS12920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPB59_RS12925	COG1011	Hydrolase
EPB59_RS12930	COG3287	FIST C domain
EPB59_RS12930	COG2199	diguanylate cyclase activity
EPB59_RS12930	COG2200	EAL domain
EPB59_RS12945	COG0561	phosphatase activity
EPB59_RS12950	COG2267	carboxylic ester hydrolase activity
EPB59_RS12955	COG1280	lysine exporter protein (LysE YggA)
EPB59_RS12960	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB59_RS12965	COG0783	Belongs to the Dps family
EPB59_RS13000	COG0742	ribosomal rna small subunit methyltransferase
EPB59_RS13005	COG0552	protein localization to endoplasmic reticulum
EPB59_RS13010	COG2884	Cell division ATP-binding protein ftsE
EPB59_RS13015	COG2177	Part of the ABC transporter FtsEX involved in
EPB59_RS13020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPB59_RS13025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB59_RS13040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB59_RS13055	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPB59_RS13125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB59_RS13130	COG5001	Diguanylate cyclase
EPB59_RS13130	COG3300	MHYT domain
EPB59_RS13140	COG3852	Histidine kinase
EPB59_RS13150	COG0174	glutamine synthetase
EPB59_RS13160	COG1217	gtp-binding protein TYPA
EPB59_RS13170	COG1295	ribonuclease BN
EPB59_RS13175	COG1490	D-aminoacyl-tRNA deacylase activity
EPB59_RS13180	COG0456	acetyltransferase
EPB59_RS13190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EPB59_RS13195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EPB59_RS13200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPB59_RS13205	COG3031	protein transport across the cell outer membrane
EPB59_RS13215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB59_RS13220	COG1459	type II secretion system
EPB59_RS13225	COG2165	general secretion pathway protein
EPB59_RS13230	COG2165	general secretion pathway protein
EPB59_RS13235	COG2165	general secretion pathway protein
EPB59_RS13240	COG4795	General secretion pathway protein
EPB59_RS13245	COG3156	type II secretion system protein K
EPB59_RS13250	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB59_RS13255	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB59_RS13265	COG1218	3'(2'),5'-bisphosphate nucleotidase
EPB59_RS13270	COG0494	nUDIX hydrolase
EPB59_RS13280	COG1040	competence protein
EPB59_RS13285	COG0596	Alpha beta hydrolase
EPB59_RS13295	COG2183	response to ionizing radiation
EPB59_RS13300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB59_RS13320	COG4628	conserved protein (DUF2132)
EPB59_RS13455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB59_RS13490	COG3040	lipid binding
EPB59_RS13505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EPB59_RS13595	COG0456	acetyltransferase
EPB59_RS13620	COG0494	nUDIX hydrolase
EPB59_RS13715	COG1942	4-Oxalocrotonate Tautomerase
EPB59_RS13755	COG0384	phenazine biosynthesis protein PhzF
EPB59_RS13800	COG0346	lactoylglutathione lyase activity
EPB59_RS13820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EPB59_RS13905	COG1328	CTP reductase activity
EPB59_RS13910	COG0602	queuosine metabolic process
EPB59_RS13920	COG0189	ligase activity
EPB59_RS13920	COG4067	protein conserved in archaea
EPB59_RS13925	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPB59_RS13925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB59_RS13925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB59_RS13930	COG1105	Belongs to the carbohydrate kinase PfkB family
EPB59_RS13935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB59_RS13935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB59_RS13940	COG1609	Transcriptional regulator
EPB59_RS13945	COG0420	3'-5' exonuclease activity
EPB59_RS13950	COG0419	ATPase involved in DNA repair
EPB59_RS13955	COG2205	protein histidine kinase activity
EPB59_RS13955	COG0784	Response regulator, receiver
EPB59_RS13960	COG0156	8-amino-7-oxononanoate synthase activity
EPB59_RS13970	COG0038	chloride channel
EPB59_RS13975	COG0523	cobalamin synthesis protein
EPB59_RS13985	COG3158	transport of potassium into the cell
EPB59_RS13990	COG1013	pyruvate-flavodoxin oxidoreductase activity
EPB59_RS13990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EPB59_RS13990	COG0674	pyruvate-flavodoxin oxidoreductase activity
EPB59_RS13990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPB59_RS13995	COG2205	protein histidine kinase activity
EPB59_RS14000	COG0745	RESPONSE REGULATOR receiver
EPB59_RS14005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB59_RS14020	COG2200	EAL domain
EPB59_RS14030	COG3038	cytochrome b561
EPB59_RS14040	COG2116	formate transmembrane transporter activity
EPB59_RS14045	COG0583	DNA-binding transcription factor activity
EPB59_RS14055	COG3593	DNA synthesis involved in DNA repair
EPB59_RS14060	COG0737	Belongs to the 5'-nucleotidase family
EPB59_RS14075	COG2824	Alkylphosphonate utilization operon protein PhnA
EPB59_RS14105	COG3706	GGDEF domain
EPB59_RS14125	COG3706	GGDEF domain
EPB59_RS14140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPB59_RS14145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EPB59_RS14175	COG3140	Belongs to the UPF0181 family
EPB59_RS14190	COG0023	Translation Initiation Factor
EPB59_RS14215	COG0583	DNA-binding transcription factor activity
EPB59_RS14220	COG4771	TonB-dependent receptor
EPB59_RS14235	COG2050	protein possibly involved in aromatic compounds catabolism
EPB59_RS14240	COG0501	Belongs to the peptidase M48B family
EPB59_RS14255	COG0625	glutathione transferase activity
EPB59_RS14270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EPB59_RS14275	COG4172	Belongs to the ABC transporter superfamily
EPB59_RS14280	COG4239	(ABC) transporter, permease
EPB59_RS14285	COG4174	ABC transporter (Permease)
EPB59_RS14290	COG4166	transmembrane transport
EPB59_RS14310	COG3104	oligopeptide transport
EPB59_RS14330	COG3842	ATPase activity
EPB59_RS14335	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB59_RS14340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPB59_RS14345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB59_RS14350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB59_RS14355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB59_RS14365	COG3842	ATPase activity
EPB59_RS14375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB59_RS14390	COG1175	transmembrane transport
EPB59_RS14395	COG3833	ABC-type maltose transport systems, permease component
EPB59_RS14415	COG1011	Hydrolase
EPB59_RS14430	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EPB59_RS14435	COG1970	mechanosensitive ion channel activity
EPB59_RS14440	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EPB59_RS14445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB59_RS14445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB59_RS14450	COG0302	gtp cyclohydrolase
EPB59_RS14460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB59_RS14470	COG2897	thiosulfate sulfurtransferase activity
EPB59_RS14480	COG2390	Transcriptional regulator
EPB59_RS14490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB59_RS14525	COG1335	isochorismatase
EPB59_RS14545	COG0583	DNA-binding transcription factor activity
EPB59_RS14550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPB59_RS14575	COG2391	methyltransferase activity
EPB59_RS14635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB59_RS14635	COG1263	PTS System
EPB59_RS14640	COG1609	Transcriptional regulator
EPB59_RS14645	COG1621	beta-fructofuranosidase activity
EPB59_RS14655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPB59_RS14670	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB59_RS14675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB59_RS14680	COG0840	transmembrane signaling receptor activity
EPB59_RS14685	COG3069	C4-dicarboxylate transmembrane transporter activity
EPB59_RS14690	COG1760	l-serine dehydratase
EPB59_RS14695	COG2197	response regulator
EPB59_RS14700	COG3850	Histidine kinase
EPB59_RS14705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB59_RS14715	COG0243	molybdopterin cofactor binding
EPB59_RS14725	COG3005	denitrification pathway
EPB59_RS14735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB59_RS14740	COG2197	response regulator
EPB59_RS14745	COG3851	Histidine kinase
EPB59_RS14750	COG2271	Major facilitator Superfamily
EPB59_RS14755	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB59_RS14765	COG3842	ATPase activity
EPB59_RS14770	COG3243	poly(R)-hydroxyalkanoic acid synthase
EPB59_RS14780	COG0183	Belongs to the thiolase family
EPB59_RS14790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB59_RS14795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB59_RS14810	COG3706	GGDEF domain
EPB59_RS14815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB59_RS14825	COG1979	alcohol dehydrogenase
EPB59_RS14840	COG4191	Histidine kinase
EPB59_RS14850	COG2271	Major facilitator Superfamily
EPB59_RS14855	COG0469	pyruvate kinase activity
EPB59_RS14860	COG0784	Response regulator, receiver
EPB59_RS14860	COG2198	Histidine kinase
EPB59_RS14860	COG2205	protein histidine kinase activity
EPB59_RS14865	COG1879	ABC-type sugar transport system periplasmic component
EPB59_RS14870	COG1803	Methylglyoxal synthase
EPB59_RS14875	COG1335	isochorismatase
EPB59_RS14885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB59_RS14900	COG0210	DNA helicase
EPB59_RS14905	COG1289	transmembrane transporter activity
EPB59_RS14925	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EPB59_RS14930	COG4149	molybdate abc transporter
EPB59_RS14935	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPB59_RS14940	COG1492	cobalamin metabolic process
EPB59_RS14960	COG5002	protein histidine kinase activity
EPB59_RS14960	COG0784	Response regulator, receiver
EPB59_RS14965	COG1879	ABC-type sugar transport system periplasmic component
EPB59_RS14975	COG2827	Endonuclease containing a URI domain
EPB59_RS14980	COG3132	Protein of unknown function, DUF480
EPB59_RS14990	COG2926	Belongs to the UPF0265 family
EPB59_RS15010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB59_RS15015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPB59_RS15025	COG0247	lactate metabolic process
EPB59_RS15030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB59_RS15035	COG3118	belongs to the thioredoxin family
EPB59_RS15060	COG4160	amino acid transport
EPB59_RS15065	COG4215	(ABC) transporter
EPB59_RS15070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB59_RS15075	COG1126	abc transporter atp-binding protein
EPB59_RS15085	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EPB59_RS15095	COG0494	nUDIX hydrolase
EPB59_RS15100	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EPB59_RS15110	COG1309	transcriptional regulator
EPB59_RS15115	COG0513	Belongs to the DEAD box helicase family
EPB59_RS15120	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EPB59_RS15125	COG0814	amino acid
EPB59_RS15130	COG0840	transmembrane signaling receptor activity
EPB59_RS15135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPB59_RS15140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EPB59_RS15145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EPB59_RS15150	COG1984	allophanate hydrolase subunit 2
EPB59_RS15165	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EPB59_RS15170	COG4181	ATPase activity
EPB59_RS15180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB59_RS15185	COG1716	ATPase activity
EPB59_RS15185	COG5001	Diguanylate cyclase
EPB59_RS15195	COG0484	heat shock protein binding
EPB59_RS15225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB59_RS15230	COG1368	sulfuric ester hydrolase activity
EPB59_RS15245	COG0513	Belongs to the DEAD box helicase family
EPB59_RS15260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPB59_RS15270	COG3046	protein related to deoxyribodipyrimidine photolyase
EPB59_RS15275	COG3397	chitin binding
EPB59_RS15315	COG5002	protein histidine kinase activity
EPB59_RS15320	COG0745	RESPONSE REGULATOR receiver
EPB59_RS15370	COG0561	phosphatase activity
EPB59_RS15375	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EPB59_RS15380	COG3623	hexulose-6-phosphate isomerase
EPB59_RS15395	COG2149	membrane
EPB59_RS15405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB59_RS15405	COG1263	PTS System
EPB59_RS15410	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPB59_RS15420	COG1073	alpha beta
EPB59_RS15425	COG1073	alpha beta
EPB59_RS15435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB59_RS15455	COG4604	ABC transporter, ATP-binding protein
EPB59_RS15460	COG4605	iron ion homeostasis
EPB59_RS15465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB59_RS15490	COG5380	lipid catabolic process
EPB59_RS15495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPB59_RS15500	COG0840	transmembrane signaling receptor activity
EPB59_RS15510	COG3240	lipase activity
EPB59_RS15515	COG3706	GGDEF domain
EPB59_RS15525	COG2814	Major facilitator Superfamily
EPB59_RS15530	COG1757	Na H antiporter
EPB59_RS15540	COG4191	Histidine kinase
EPB59_RS15540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB59_RS15545	COG3437	response regulator, receiver
EPB59_RS15545	COG0784	Response regulator, receiver
EPB59_RS15550	COG0840	transmembrane signaling receptor activity
EPB59_RS15555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EPB59_RS15560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPB59_RS15565	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB59_RS15570	COG0513	Belongs to the DEAD box helicase family
EPB59_RS15580	COG0516	GMP reductase activity
EPB59_RS15590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB59_RS15600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB59_RS15605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPB59_RS15605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPB59_RS15630	COG3036	rescue of stalled ribosome
EPB59_RS15635	COG1278	Cold shock
EPB59_RS15640	COG1017	nitric oxide dioxygenase activity
EPB59_RS15640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB59_RS15645	COG3604	Transcriptional regulator
EPB59_RS15655	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB59_RS15660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB59_RS15675	COG0840	transmembrane signaling receptor activity
EPB59_RS15680	COG0714	Associated with various cellular activities
EPB59_RS15700	COG2304	oxidoreductase activity
EPB59_RS15715	COG1278	Cold shock
EPB59_RS15730	COG3530	Putative quorum-sensing-regulated virulence factor
EPB59_RS15745	COG0814	amino acid
EPB59_RS15750	COG0488	(ABC) transporter
EPB59_RS15765	COG0579	oxidoreductase
EPB59_RS15805	COG2271	Major facilitator Superfamily
EPB59_RS15810	COG0584	glycerophosphoryl diester phosphodiesterase
EPB59_RS15820	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EPB59_RS15830	COG3447	MASE1 domain protein
EPB59_RS15830	COG5002	protein histidine kinase activity
EPB59_RS15830	COG5001	Diguanylate cyclase
EPB59_RS15835	COG1609	Transcriptional regulator
EPB59_RS15840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB59_RS15845	COG1879	ABC-type sugar transport system periplasmic component
EPB59_RS15850	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB59_RS15855	COG1129	ABC transporter
EPB59_RS15860	COG1869	D-ribose catabolic process
EPB59_RS15875	COG3501	Rhs element vgr protein
EPB59_RS15875	COG3409	Peptidoglycan-binding domain 1 protein
EPB59_RS15900	COG3829	transcription factor binding
EPB59_RS15975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB59_RS15980	COG2771	luxR family
EPB59_RS15980	COG2200	EAL domain
EPB59_RS15990	COG0840	transmembrane signaling receptor activity
EPB59_RS15995	COG0673	inositol 2-dehydrogenase activity
EPB59_RS16000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EPB59_RS16015	COG1342	Belongs to the UPF0251 family
EPB59_RS16030	COG1301	dicarboxylic acid transport
EPB59_RS16035	COG0700	Nucleoside recognition
EPB59_RS16040	COG3366	ferrous iron transmembrane transporter activity
EPB59_RS16045	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EPB59_RS16050	COG4565	transcriptional regulatory protein
EPB59_RS16060	COG0471	metal ion transport
EPB59_RS16075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EPB59_RS16080	COG2259	Doxx family
EPB59_RS16105	COG0363	glucosamine-6-phosphate deaminase activity
EPB59_RS16115	COG0583	DNA-binding transcription factor activity
EPB59_RS16125	COG1523	belongs to the glycosyl hydrolase 13 family
EPB59_RS16155	COG1914	H( )-stimulated, divalent metal cation uptake system
EPB59_RS16165	COG0840	transmembrane signaling receptor activity
EPB59_RS16180	COG0840	transmembrane signaling receptor activity
EPB59_RS16190	COG0513	Belongs to the DEAD box helicase family
EPB59_RS16200	COG2186	Transcriptional regulator
EPB59_RS16210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB59_RS16220	COG0246	Mannitol dehydrogenase
EPB59_RS16225	COG1904	glucuronate isomerase
EPB59_RS16230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB59_RS16235	COG0800	Aldolase
EPB59_RS16245	COG0583	DNA-binding transcription factor activity
EPB59_RS16255	COG1902	pentaerythritol trinitrate reductase activity
EPB59_RS16265	COG1132	(ABC) transporter
EPB59_RS16275	COG1902	pentaerythritol trinitrate reductase activity
EPB59_RS16285	COG1280	lysine exporter protein (LysE YggA)
EPB59_RS16290	COG2207	Transcriptional regulator
EPB59_RS16310	COG1846	Transcriptional regulator
EPB59_RS16315	COG1764	response to oxidative stress
EPB59_RS16320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB59_RS16325	COG0697	spore germination
EPB59_RS16345	COG2814	Major facilitator Superfamily
EPB59_RS16350	COG0583	DNA-binding transcription factor activity
EPB59_RS16355	COG3300	MHYT domain
EPB59_RS16355	COG5001	Diguanylate cyclase
EPB59_RS16360	COG0739	heme binding
EPB59_RS16370	COG0659	secondary active sulfate transmembrane transporter activity
EPB59_RS16375	COG3314	Sporulation integral membrane protein YlbJ
EPB59_RS16390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB59_RS16395	COG0581	inorganic phosphate transmembrane transporter activity
EPB59_RS16400	COG0573	inorganic phosphate transmembrane transporter activity
EPB59_RS16405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPB59_RS16435	COG1770	oligopeptidase
EPB59_RS16440	COG0513	Belongs to the DEAD box helicase family
EPB59_RS16450	COG1376	ErfK ybiS ycfS ynhG family protein
EPB59_RS16450	COG1388	LysM domain
EPB59_RS16455	COG0415	Belongs to the DNA photolyase family
EPB59_RS16460	COG0789	Transcriptional regulator
EPB59_RS16465	COG3272	Protein of unknown function (DUF1722)
EPB59_RS16470	COG0813	purine-nucleoside phosphorylase activity
EPB59_RS16505	COG0786	glutamate:sodium symporter activity
EPB59_RS16520	COG1999	signal sequence binding
EPB59_RS16530	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EPB59_RS16535	COG0671	phosphoesterase, PA-phosphatase related
EPB59_RS16580	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB59_RS16585	COG0471	metal ion transport
EPB59_RS16615	COG4104	PAAR repeat-containing protein
EPB59_RS16620	COG3501	Rhs element vgr protein
EPB59_RS16630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPB59_RS16635	COG1640	4-alpha-glucanotransferase
EPB59_RS16640	COG0058	SHG alpha-glucan phosphorylase activity
EPB59_RS16645	COG2909	trisaccharide binding
EPB59_RS16660	COG2084	Dehydrogenase
EPB59_RS16665	COG0217	transcriptional regulatory protein
EPB59_RS16700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EPB59_RS16705	COG1444	tRNA N-acetyltransferase activity
EPB59_RS16725	COG4221	oxidoreductase activity
EPB59_RS16740	COG0642	Histidine kinase
EPB59_RS16745	COG2194	sulfuric ester hydrolase activity
EPB59_RS16755	COG0745	RESPONSE REGULATOR receiver
EPB59_RS16760	COG2198	Histidine kinase
EPB59_RS16760	COG0643	Histidine kinase
EPB59_RS16765	COG0835	chemotaxis
EPB59_RS16770	COG0835	chemotaxis
EPB59_RS16775	COG0840	transmembrane signaling receptor activity
EPB59_RS16780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPB59_RS16815	COG2274	protein secretion by the type I secretion system
EPB59_RS16845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPB59_RS16870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB59_RS16900	COG1982	Orn Lys Arg decarboxylase major
EPB59_RS16905	COG0531	amino acid
EPB59_RS16920	COG1901	pseudouridine methyltransferase
EPB59_RS16930	COG4221	oxidoreductase activity
EPB59_RS16945	COG2910	NAD(P)H-binding
EPB59_RS16955	COG1335	isochorismatase
EPB59_RS16965	COG1846	Transcriptional regulator
EPB59_RS16970	COG0697	spore germination
EPB59_RS16990	COG0673	inositol 2-dehydrogenase activity
EPB59_RS16995	COG3722	fumarate hydratase activity
EPB59_RS17000	COG0246	Mannitol dehydrogenase
EPB59_RS17005	COG2213	PTS system mannitol-specific
EPB59_RS17005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB59_RS17010	COG0739	heme binding
EPB59_RS17020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB59_RS17025	COG4597	amino acid ABC transporter
EPB59_RS17030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB59_RS17040	COG1126	abc transporter atp-binding protein
EPB59_RS17045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB59_RS17050	COG0534	Mate efflux family protein
EPB59_RS17055	COG0840	transmembrane signaling receptor activity
EPB59_RS17070	COG1620	l-lactate permease
EPB59_RS17075	COG0583	DNA-binding transcription factor activity
EPB59_RS17100	COG1067	ATP-dependent peptidase activity
EPB59_RS17105	COG0840	transmembrane signaling receptor activity
EPB59_RS17110	COG2211	Major facilitator Superfamily
EPB59_RS17120	COG3123	guanosine phosphorylase activity
EPB59_RS17125	COG1741	Belongs to the pirin family
EPB59_RS17135	COG5001	Diguanylate cyclase
EPB59_RS17140	COG0583	DNA-binding transcription factor activity
EPB59_RS17160	COG3706	GGDEF domain
EPB59_RS17175	COG3706	GGDEF domain
EPB59_RS17180	COG1846	Transcriptional regulator
EPB59_RS17185	COG0784	Response regulator, receiver
EPB59_RS17185	COG0835	chemotaxis
EPB59_RS17190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB59_RS17200	COG0393	Putative heavy-metal-binding
EPB59_RS17215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB59_RS17220	COG3842	ATPase activity
EPB59_RS17230	COG1175	transmembrane transport
EPB59_RS17235	COG3833	ABC-type maltose transport systems, permease component
EPB59_RS17250	COG1349	DNA-binding transcription factor activity
EPB59_RS17255	COG2199	diguanylate cyclase activity
EPB59_RS17275	COG1278	Cold shock
EPB59_RS17280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB59_RS17290	COG0488	(ABC) transporter
EPB59_RS17295	COG2354	Protein conserved in bacteria
EPB59_RS17300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB59_RS17310	COG3152	Membrane
EPB59_RS17320	COG0418	dihydroorotase activity
EPB59_RS17325	COG0633	Ferredoxin
EPB59_RS17325	COG3217	Mosc domain protein beta barrel domain protein
EPB59_RS17325	COG0633	Ferredoxin
EPB59_RS17325	COG3217	Mosc domain protein beta barrel domain protein
EPB59_RS17360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EPB59_RS17365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB59_RS17375	COG0848	biopolymer transport protein
EPB59_RS17380	COG0811	peptide transport
EPB59_RS17385	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPB59_RS17395	COG3721	Heme iron utilization protein
EPB59_RS17400	COG0748	coenzyme F420 binding
EPB59_RS17410	COG3835	regulator
EPB59_RS17415	COG2610	gluconate transmembrane transporter activity
EPB59_RS17450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB59_RS17455	COG0363	glucosamine-6-phosphate deaminase activity
EPB59_RS17460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPB59_RS17470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPB59_RS17490	COG0346	lactoylglutathione lyase activity
EPB59_RS17500	COG2873	o-acetylhomoserine
EPB59_RS17505	COG0156	8-amino-7-oxononanoate synthase activity
EPB59_RS17510	COG1063	alcohol dehydrogenase
EPB59_RS17545	COG0583	DNA-binding transcription factor activity
EPB59_RS17550	COG1686	Belongs to the peptidase S11 family
EPB59_RS17560	COG3047	cAMP biosynthetic process
EPB59_RS17565	COG3227	Zinc metalloprotease (Elastase)
EPB59_RS17570	COG2267	carboxylic ester hydrolase activity
EPB59_RS17575	COG2067	long-chain fatty acid transport protein
EPB59_RS17580	COG0366	Alpha amylase catalytic
EPB59_RS17585	COG4989	oxidoreductase activity
EPB59_RS17615	COG3275	phosphorelay sensor kinase activity
EPB59_RS17620	COG3279	Response regulator of the LytR AlgR family
EPB59_RS17635	COG0531	amino acid
EPB59_RS17660	COG1765	OsmC-like protein
EPB59_RS17665	COG1253	flavin adenine dinucleotide binding
EPB59_RS17690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB59_RS17705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB59_RS17715	COG2154	pterin-4-alpha-carbinolamine dehydratase
EPB59_RS17720	COG0534	Mate efflux family protein
EPB59_RS17735	COG0456	acetyltransferase
EPB59_RS17740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB59_RS17745	COG0662	Cupin 2, conserved barrel domain protein
EPB59_RS17750	COG0527	aspartate kinase activity
EPB59_RS17755	COG2239	Acts as a magnesium transporter
EPB59_RS17780	COG1166	arginine decarboxylase activity
EPB59_RS17785	COG0010	Belongs to the arginase family
EPB59_RS17800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB59_RS17805	COG0800	Aldolase
EPB59_RS17810	COG1085	galactose-1-phosphate uridylyltransferase
EPB59_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
EPB59_RS17835	COG2199	diguanylate cyclase activity
EPB59_RS17840	COG3119	arylsulfatase activity
EPB59_RS17845	COG3119	arylsulfatase activity
EPB59_RS17850	COG0641	radical SAM
EPB59_RS17870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB59_RS17880	COG1414	Transcriptional regulator
EPB59_RS17895	COG1686	Belongs to the peptidase S11 family
EPB59_RS17915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPB59_RS17915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPB59_RS17920	COG0509	glycine decarboxylation via glycine cleavage system
EPB59_RS17925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB59_RS17935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EPB59_RS17940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPB59_RS17950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPB59_RS17955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EPB59_RS18065	COG0456	acetyltransferase
EPB59_RS18095	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EPB59_RS18145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EPB59_RS18170	COG3040	lipid binding
EPB59_RS18375	COG0625	glutathione transferase activity