locus-tag	class	description
GPX85_RS00065	COG3344	reverse transcriptase
GPX85_RS00165	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPX85_RS00220	COG0500	methyltransferase
GPX85_RS00235	COG0242	peptide deformylase activity
GPX85_RS00265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPX85_RS00270	COG0513	Belongs to the DEAD box helicase family
GPX85_RS00280	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPX85_RS00310	COG0444	Belongs to the ABC transporter superfamily
GPX85_RS00315	COG4608	Belongs to the ABC transporter superfamily
GPX85_RS00320	COG0601	transmembrane transport
GPX85_RS00325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPX85_RS00335	COG0527	aspartate kinase activity
GPX85_RS00340	COG0662	Cupin 2, conserved barrel domain protein
GPX85_RS00345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPX85_RS00350	COG0456	acetyltransferase
GPX85_RS00355	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPX85_RS00360	COG3186	Phenylalanine-4-hydroxylase
GPX85_RS00365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPX85_RS00370	COG2264	protein methyltransferase activity
GPX85_RS00390	COG1765	OsmC-like protein
GPX85_RS00420	COG1278	Cold shock
GPX85_RS00435	COG4145	pantothenate transmembrane transporter activity
GPX85_RS00440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPX85_RS00445	COG4604	ABC transporter, ATP-binding protein
GPX85_RS00450	COG4605	iron ion homeostasis
GPX85_RS00455	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPX85_RS00460	COG4607	ABC-type enterochelin transport system periplasmic component
GPX85_RS00470	COG2814	Major facilitator Superfamily
GPX85_RS00480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPX85_RS00485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPX85_RS00490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPX85_RS00495	COG4989	oxidoreductase activity
GPX85_RS00505	COG0366	Alpha amylase catalytic
GPX85_RS00510	COG2067	long-chain fatty acid transport protein
GPX85_RS00515	COG2267	carboxylic ester hydrolase activity
GPX85_RS00520	COG3047	cAMP biosynthetic process
GPX85_RS00525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPX85_RS00530	COG0784	Response regulator, receiver
GPX85_RS00530	COG0835	chemotaxis
GPX85_RS00535	COG3706	GGDEF domain
GPX85_RS00540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPX85_RS00555	COG1741	Belongs to the pirin family
GPX85_RS00560	COG3123	guanosine phosphorylase activity
GPX85_RS00570	COG1067	ATP-dependent peptidase activity
GPX85_RS00580	COG0583	DNA-binding transcription factor activity
GPX85_RS00585	COG1620	l-lactate permease
GPX85_RS00590	COG1304	FMN binding
GPX85_RS00600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPX85_RS00605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPX85_RS00610	COG1280	lysine exporter protein (LysE YggA)
GPX85_RS00615	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPX85_RS00635	COG5001	Diguanylate cyclase
GPX85_RS00640	COG0739	heme binding
GPX85_RS00650	COG0659	secondary active sulfate transmembrane transporter activity
GPX85_RS00660	COG0513	Belongs to the DEAD box helicase family
GPX85_RS00685	COG0363	glucosamine-6-phosphate deaminase activity
GPX85_RS00695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPX85_RS00705	COG2200	EAL domain
GPX85_RS00705	COG2771	luxR family
GPX85_RS00715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPX85_RS00725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPX85_RS00735	COG2259	Doxx family
GPX85_RS00745	COG2814	Major facilitator Superfamily
GPX85_RS00760	COG0848	biopolymer transport protein
GPX85_RS00765	COG0811	peptide transport
GPX85_RS00770	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPX85_RS00790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPX85_RS00800	COG1957	nucleoside hydrolase
GPX85_RS00805	COG4628	conserved protein (DUF2132)
GPX85_RS00815	COG0583	DNA-binding transcription factor activity
GPX85_RS00840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPX85_RS00850	COG2977	Belongs to the P-Pant transferase superfamily
GPX85_RS00855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPX85_RS00860	COG1028	Short-chain dehydrogenase reductase Sdr
GPX85_RS00865	COG1169	isochorismate synthase
GPX85_RS00875	COG3433	isochorismatase activity
GPX85_RS00875	COG1535	isochorismatase
GPX85_RS00880	COG4592	Periplasmic binding protein
GPX85_RS00890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPX85_RS00895	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPX85_RS00900	COG1120	ATPase activity
GPX85_RS00915	COG2382	esterase
GPX85_RS00920	COG1629	transport
GPX85_RS00920	COG4774	siderophore transport
GPX85_RS00960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPX85_RS00965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPX85_RS00965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPX85_RS00975	COG2201	protein-glutamate methylesterase activity
GPX85_RS00985	COG1278	Cold shock
GPX85_RS00990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPX85_RS00990	COG1017	nitric oxide dioxygenase activity
GPX85_RS00995	COG3604	Transcriptional regulator
GPX85_RS01005	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPX85_RS01010	COG0366	Alpha amylase catalytic
GPX85_RS01025	COG0840	transmembrane signaling receptor activity
GPX85_RS01030	COG0714	Associated with various cellular activities
GPX85_RS01045	COG2304	oxidoreductase activity
GPX85_RS01065	COG3724	N-succinylarginine dihydrolase activity
GPX85_RS01075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPX85_RS01090	COG0513	Belongs to the DEAD box helicase family
GPX85_RS01100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPX85_RS01105	COG2184	nucleotidyltransferase activity
GPX85_RS01115	COG0745	RESPONSE REGULATOR receiver
GPX85_RS01115	COG3706	GGDEF domain
GPX85_RS01120	COG3530	Putative quorum-sensing-regulated virulence factor
GPX85_RS01130	COG0583	DNA-binding transcription factor activity
GPX85_RS01145	COG2271	Major facilitator Superfamily
GPX85_RS01160	COG3730	PTS system glucitol sorbitol-specific
GPX85_RS01165	COG1349	DNA-binding transcription factor activity
GPX85_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
GPX85_RS01180	COG3731	PTS system glucitol sorbitol-specific IIA component
GPX85_RS01190	COG3730	PTS system glucitol sorbitol-specific
GPX85_RS01200	COG1609	Transcriptional regulator
GPX85_RS01205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX85_RS01210	COG1879	ABC-type sugar transport system periplasmic component
GPX85_RS01215	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPX85_RS01220	COG1129	ABC transporter
GPX85_RS01225	COG1869	D-ribose catabolic process
GPX85_RS01245	COG0564	pseudouridine synthase activity
GPX85_RS01255	COG0739	heme binding
GPX85_RS01260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX85_RS01260	COG2213	PTS system mannitol-specific
GPX85_RS01270	COG3722	fumarate hydratase activity
GPX85_RS01280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPX85_RS01290	COG5002	protein histidine kinase activity
GPX85_RS01300	COG0095	Lipoate-protein ligase
GPX85_RS01310	COG0477	Major facilitator Superfamily
GPX85_RS01315	COG4628	conserved protein (DUF2132)
GPX85_RS01330	COG2076	Multidrug Resistance protein
GPX85_RS01340	COG0702	epimerase
GPX85_RS01345	COG0583	DNA-binding transcription factor activity
GPX85_RS01350	COG0840	transmembrane signaling receptor activity
GPX85_RS01360	COG0513	Belongs to the DEAD box helicase family
GPX85_RS01365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPX85_RS01370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPX85_RS01395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPX85_RS01400	COG0259	pyridoxamine-phosphate oxidase activity
GPX85_RS01410	COG0745	RESPONSE REGULATOR receiver
GPX85_RS01410	COG3706	GGDEF domain
GPX85_RS01415	COG2084	Dehydrogenase
GPX85_RS01420	COG0217	transcriptional regulatory protein
GPX85_RS01450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPX85_RS01455	COG1444	tRNA N-acetyltransferase activity
GPX85_RS01460	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPX85_RS01470	COG3046	protein related to deoxyribodipyrimidine photolyase
GPX85_RS01485	COG3706	GGDEF domain
GPX85_RS01485	COG0745	RESPONSE REGULATOR receiver
GPX85_RS01500	COG2909	trisaccharide binding
GPX85_RS01505	COG0058	SHG alpha-glucan phosphorylase activity
GPX85_RS01510	COG1640	4-alpha-glucanotransferase
GPX85_RS01515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPX85_RS01525	COG0471	metal ion transport
GPX85_RS01530	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPX85_RS01540	COG0840	transmembrane signaling receptor activity
GPX85_RS01555	COG0010	Belongs to the arginase family
GPX85_RS01560	COG0671	phosphoesterase, PA-phosphatase related
GPX85_RS01570	COG1132	(ABC) transporter
GPX85_RS01580	COG4580	involved in the transport of maltose and maltodextrins
GPX85_RS01595	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPX85_RS01610	COG3706	GGDEF domain
GPX85_RS01625	COG0813	purine-nucleoside phosphorylase activity
GPX85_RS01630	COG3272	Protein of unknown function (DUF1722)
GPX85_RS01635	COG0789	Transcriptional regulator
GPX85_RS01640	COG0415	Belongs to the DNA photolyase family
GPX85_RS01650	COG0786	glutamate:sodium symporter activity
GPX85_RS01655	COG0786	glutamate:sodium symporter activity
GPX85_RS01665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPX85_RS01670	COG1342	Belongs to the UPF0251 family
GPX85_RS01685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPX85_RS01690	COG0673	inositol 2-dehydrogenase activity
GPX85_RS01695	COG1472	Belongs to the glycosyl hydrolase 3 family
GPX85_RS01700	COG3876	Protein conserved in bacteria
GPX85_RS01705	COG2199	diguanylate cyclase activity
GPX85_RS01705	COG2200	EAL domain
GPX85_RS01705	COG2202	Pas domain
GPX85_RS01750	COG2197	response regulator
GPX85_RS01755	COG2205	protein histidine kinase activity
GPX85_RS01755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX85_RS01760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPX85_RS01765	COG0783	Belongs to the Dps family
GPX85_RS01770	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPX85_RS01790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPX85_RS01795	COG0363	glucosamine-6-phosphate deaminase activity
GPX85_RS01800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPX85_RS01805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPX85_RS01835	COG3240	lipase activity
GPX85_RS01840	COG0156	8-amino-7-oxononanoate synthase activity
GPX85_RS01845	COG1063	alcohol dehydrogenase
GPX85_RS01865	COG2376	Dihydroxyacetone kinase
GPX85_RS01870	COG1461	Dihydroxyacetone kinase
GPX85_RS01885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX85_RS01890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPX85_RS01900	COG3842	ATPase activity
GPX85_RS01910	COG1175	transmembrane transport
GPX85_RS01915	COG3833	ABC-type maltose transport systems, permease component
GPX85_RS01935	COG1607	acyl-coa hydrolase
GPX85_RS01950	COG1349	DNA-binding transcription factor activity
GPX85_RS01970	COG0418	dihydroorotase activity
GPX85_RS01975	COG3217	Mosc domain protein beta barrel domain protein
GPX85_RS01975	COG0633	Ferredoxin
GPX85_RS02005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPX85_RS02010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPX85_RS02015	COG4558	Periplasmic binding protein
GPX85_RS02020	COG3721	Heme iron utilization protein
GPX85_RS02025	COG0748	coenzyme F420 binding
GPX85_RS02040	COG1166	arginine decarboxylase activity
GPX85_RS02045	COG0010	Belongs to the arginase family
GPX85_RS02050	COG1686	Belongs to the peptidase S11 family
GPX85_RS02070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPX85_RS02085	COG2814	Major facilitator Superfamily
GPX85_RS02090	COG3118	belongs to the thioredoxin family
GPX85_RS02095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPX85_RS02100	COG0247	lactate metabolic process
GPX85_RS02105	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPX85_RS02110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPX85_RS02115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPX85_RS02145	COG2827	Endonuclease containing a URI domain
GPX85_RS02150	COG1879	ABC-type sugar transport system periplasmic component
GPX85_RS02155	COG0784	Response regulator, receiver
GPX85_RS02155	COG5002	protein histidine kinase activity
GPX85_RS02165	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPX85_RS02170	COG4149	molybdate abc transporter
GPX85_RS02175	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPX85_RS02190	COG1289	transmembrane transporter activity
GPX85_RS02195	COG0210	DNA helicase
GPX85_RS02200	COG1335	isochorismatase
GPX85_RS02205	COG1803	Methylglyoxal synthase
GPX85_RS02210	COG0387	Pfam Sodium calcium exchanger
GPX85_RS02220	COG1979	alcohol dehydrogenase
GPX85_RS02225	COG2207	Transcriptional regulator
GPX85_RS02235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPX85_RS02240	COG3706	GGDEF domain
GPX85_RS02255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPX85_RS02260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPX85_RS02265	COG3604	Transcriptional regulator
GPX85_RS02280	COG0626	cystathionine gamma-synthase activity
GPX85_RS02285	COG3385	transposase activity
GPX85_RS02290	COG0840	transmembrane signaling receptor activity
GPX85_RS02315	COG3069	C4-dicarboxylate transmembrane transporter activity
GPX85_RS02325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPX85_RS02330	COG0545	Peptidyl-prolyl cis-trans isomerase
GPX85_RS02345	COG0840	transmembrane signaling receptor activity
GPX85_RS02355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPX85_RS02360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPX85_RS02370	COG2897	thiosulfate sulfurtransferase activity
GPX85_RS02375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPX85_RS02380	COG0303	'Molybdopterin
GPX85_RS02385	COG0302	gtp cyclohydrolase
GPX85_RS02390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPX85_RS02390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPX85_RS02395	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPX85_RS02400	COG1278	Cold shock
GPX85_RS02410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPX85_RS02410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPX85_RS02425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPX85_RS02440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX85_RS02455	COG0546	phosphoglycolate phosphatase activity
GPX85_RS02475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPX85_RS02485	COG4181	ATPase activity
GPX85_RS02490	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPX85_RS02500	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPX85_RS02510	COG0840	transmembrane signaling receptor activity
GPX85_RS02515	COG0814	amino acid
GPX85_RS02520	COG0513	Belongs to the DEAD box helicase family
GPX85_RS02540	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPX85_RS02595	COG0450	alkyl hydroperoxide reductase
GPX85_RS02620	COG0640	Transcriptional regulator
GPX85_RS02655	COG4067	protein conserved in archaea
GPX85_RS02655	COG0189	ligase activity
GPX85_RS02660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX85_RS02660	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPX85_RS02660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX85_RS02665	COG1105	Belongs to the carbohydrate kinase PfkB family
GPX85_RS02670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX85_RS02670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX85_RS02675	COG1609	Transcriptional regulator
GPX85_RS02680	COG0420	3'-5' exonuclease activity
GPX85_RS02685	COG0419	ATPase involved in DNA repair
GPX85_RS02690	COG2205	protein histidine kinase activity
GPX85_RS02690	COG0784	Response regulator, receiver
GPX85_RS02695	COG0156	8-amino-7-oxononanoate synthase activity
GPX85_RS02700	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPX85_RS02705	COG1011	Hydrolase
GPX85_RS02710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPX85_RS02715	COG2188	Transcriptional regulator
GPX85_RS02740	COG2314	TM2 domain
GPX85_RS02770	COG0038	chloride channel
GPX85_RS02775	COG0523	cobalamin synthesis protein
GPX85_RS02780	COG0577	efflux transmembrane transporter activity
GPX85_RS02780	COG1136	(ABC) transporter
GPX85_RS02785	COG0577	efflux transmembrane transporter activity
GPX85_RS02785	COG1136	(ABC) transporter
GPX85_RS02790	COG1136	(ABC) transporter
GPX85_RS02790	COG0577	efflux transmembrane transporter activity
GPX85_RS02805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPX85_RS02815	COG4139	cobalamin transport
GPX85_RS02825	COG2610	gluconate transmembrane transporter activity
GPX85_RS02830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPX85_RS02835	COG3622	Belongs to the hyi family
GPX85_RS02840	COG0235	Class ii aldolase
GPX85_RS02845	COG3395	kinase activity
GPX85_RS02850	COG2084	Dehydrogenase
GPX85_RS02855	COG1349	DNA-binding transcription factor activity
GPX85_RS02860	COG3181	Tripartite tricarboxylate transporter family receptor
GPX85_RS02885	COG0488	(ABC) transporter
GPX85_RS02895	COG1328	CTP reductase activity
GPX85_RS02900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPX85_RS02925	COG0517	IMP dehydrogenase activity
GPX85_RS02935	COG3038	cytochrome b561
GPX85_RS02940	COG2353	YceI-like domain
GPX85_RS02945	COG2116	formate transmembrane transporter activity
GPX85_RS02950	COG0583	DNA-binding transcription factor activity
GPX85_RS02960	COG3593	DNA synthesis involved in DNA repair
GPX85_RS02965	COG0737	Belongs to the 5'-nucleotidase family
GPX85_RS02970	COG0861	Integral membrane protein TerC family
GPX85_RS02980	COG2824	Alkylphosphonate utilization operon protein PhnA
GPX85_RS02990	COG2050	protein possibly involved in aromatic compounds catabolism
GPX85_RS03005	COG0583	DNA-binding transcription factor activity
GPX85_RS03010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX85_RS03010	COG1042	CoA-binding domain protein
GPX85_RS03010	COG0045	succinate-CoA ligase (ADP-forming) activity
GPX85_RS03020	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPX85_RS03035	COG0023	Translation Initiation Factor
GPX85_RS03100	COG2873	o-acetylhomoserine
GPX85_RS03125	COG0745	RESPONSE REGULATOR receiver
GPX85_RS03135	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPX85_RS03140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPX85_RS03155	COG3706	GGDEF domain
GPX85_RS03165	COG0653	protein targeting
GPX85_RS03195	COG3093	addiction module antidote protein HigA
GPX85_RS03200	COG3549	Plasmid maintenance system killer
GPX85_RS03210	COG3344	reverse transcriptase
GPX85_RS03225	COG3344	reverse transcriptase
GPX85_RS03330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPX85_RS03380	COG3344	reverse transcriptase
GPX85_RS03465	COG3344	reverse transcriptase
GPX85_RS03500	COG3344	reverse transcriptase
GPX85_RS03635	COG3344	reverse transcriptase
GPX85_RS03760	COG3041	Addiction module toxin RelE StbE family
GPX85_RS03800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX85_RS03820	COG0242	peptide deformylase activity
GPX85_RS03895	COG0549	Belongs to the carbamate kinase family
GPX85_RS03900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPX85_RS03905	COG1438	arginine binding
GPX85_RS03910	COG4232	protein-disulfide reductase activity
GPX85_RS03925	COG3263	regulation of cellular component size
GPX85_RS03935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPX85_RS03945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPX85_RS03950	COG0194	GDP metabolic process
GPX85_RS03955	COG1758	RNA polymerase activity
GPX85_RS03960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPX85_RS03965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPX85_RS03970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPX85_RS03975	COG2233	PERMEase
GPX85_RS03980	COG2205	protein histidine kinase activity
GPX85_RS03985	COG0745	RESPONSE REGULATOR receiver
GPX85_RS03995	COG2610	gluconate transmembrane transporter activity
GPX85_RS04000	COG3265	gluconokinase activity
GPX85_RS04005	COG0129	dihydroxy-acid dehydratase activity
GPX85_RS04010	COG1609	Transcriptional regulator
GPX85_RS04015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPX85_RS04020	COG2183	response to ionizing radiation
GPX85_RS04030	COG0596	Alpha beta hydrolase
GPX85_RS04040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPX85_RS04040	COG0316	Belongs to the HesB IscA family
GPX85_RS04045	COG0494	nUDIX hydrolase
GPX85_RS04050	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPX85_RS04060	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPX85_RS04065	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPX85_RS04070	COG3156	type II secretion system protein K
GPX85_RS04075	COG4795	General secretion pathway protein
GPX85_RS04080	COG2165	general secretion pathway protein
GPX85_RS04085	COG2165	general secretion pathway protein
GPX85_RS04090	COG2165	general secretion pathway protein
GPX85_RS04095	COG1459	type II secretion system
GPX85_RS04100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPX85_RS04110	COG3031	protein transport across the cell outer membrane
GPX85_RS04115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPX85_RS04120	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPX85_RS04125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPX85_RS04135	COG0456	acetyltransferase
GPX85_RS04140	COG1490	D-aminoacyl-tRNA deacylase activity
GPX85_RS04155	COG0174	glutamine synthetase
GPX85_RS04165	COG3852	Histidine kinase
GPX85_RS04170	COG2204	response regulator
GPX85_RS04175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPX85_RS04240	COG4206	TonB-dependent receptor
GPX85_RS04245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPX85_RS04270	COG1160	GTP binding
GPX85_RS04290	COG2003	Belongs to the UPF0758 family
GPX85_RS04350	COG0210	DNA helicase
GPX85_RS04370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPX85_RS04375	COG0534	Mate efflux family protein
GPX85_RS04385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPX85_RS04390	COG2937	Belongs to the GPAT DAPAT family
GPX85_RS04400	COG3161	chorismate lyase activity
GPX85_RS04420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPX85_RS04425	COG2177	Part of the ABC transporter FtsEX involved in
GPX85_RS04430	COG2884	Cell division ATP-binding protein ftsE
GPX85_RS04435	COG0552	protein localization to endoplasmic reticulum
GPX85_RS04440	COG0742	ribosomal rna small subunit methyltransferase
GPX85_RS04445	COG2095	MarC family integral membrane protein
GPX85_RS04470	COG0783	Belongs to the Dps family
GPX85_RS04475	COG2267	carboxylic ester hydrolase activity
GPX85_RS04480	COG0561	phosphatase activity
GPX85_RS04500	COG3287	FIST C domain
GPX85_RS04500	COG2200	EAL domain
GPX85_RS04500	COG2199	diguanylate cyclase activity
GPX85_RS04505	COG1011	Hydrolase
GPX85_RS04525	COG0019	diaminopimelate decarboxylase activity
GPX85_RS04535	COG3072	Adenylate cyclase
GPX85_RS04545	COG0181	hydroxymethylbilane synthase activity
GPX85_RS04550	COG1587	Uroporphyrinogen-III synthase
GPX85_RS04555	COG2959	enzyme of heme biosynthesis
GPX85_RS04565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPX85_RS04575	COG3078	GTPase activator activity
GPX85_RS04585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPX85_RS04590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPX85_RS04590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPX85_RS04600	COG0084	hydrolase, TatD family'
GPX85_RS04605	COG0805	protein transport
GPX85_RS04610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPX85_RS04615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPX85_RS04620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPX85_RS04630	COG2226	methyltransferase
GPX85_RS04635	COG1322	Protein conserved in bacteria
GPX85_RS04660	COG2081	HI0933 family
GPX85_RS04670	COG1528	Iron-storage protein
GPX85_RS04680	COG0697	spore germination
GPX85_RS04690	COG0742	ribosomal rna small subunit methyltransferase
GPX85_RS04695	COG1522	sequence-specific DNA binding
GPX85_RS04715	COG0006	proline dipeptidase activity
GPX85_RS04715	COG0006	proline dipeptidase activity
GPX85_RS04745	COG4175	Glycine betaine
GPX85_RS04750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPX85_RS04765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPX85_RS04780	COG0038	chloride channel
GPX85_RS04845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPX85_RS04850	COG1739	Uncharacterized protein family UPF0029
GPX85_RS04855	COG1024	Enoyl-CoA hydratase
GPX85_RS04855	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPX85_RS04860	COG0183	Belongs to the thiolase family
GPX85_RS04865	COG0583	DNA-binding transcription factor activity
GPX85_RS04880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPX85_RS04890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPX85_RS04905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPX85_RS04915	COG0356	it plays a direct role in the translocation of protons across the membrane
GPX85_RS04925	COG1475	DNA binding
GPX85_RS04930	COG1192	Involved in chromosome partitioning
GPX85_RS04940	COG0445	tRNA wobble uridine modification
GPX85_RS04945	COG0071	Belongs to the small heat shock protein (HSP20) family
GPX85_RS04950	COG1943	Transposase
GPX85_RS04965	COG0187	DNA topoisomerase II activity
GPX85_RS04975	COG0592	DNA-directed DNA polymerase activity
GPX85_RS04980	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPX85_RS04985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPX85_RS04995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPX85_RS05000	COG0706	membrane insertase activity
GPX85_RS05005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPX85_RS05015	COG5002	protein histidine kinase activity
GPX85_RS05025	COG0745	RESPONSE REGULATOR receiver
GPX85_RS05030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPX85_RS05040	COG2922	Belongs to the Smg family
GPX85_RS05045	COG0758	DNA mediated transformation
GPX85_RS05055	COG0242	peptide deformylase activity
GPX85_RS05065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPX85_RS05065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPX85_RS05070	COG0569	domain protein
GPX85_RS05075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPX85_RS05080	COG1272	protein, Hemolysin III
GPX85_RS05090	COG3084	Protein conserved in bacteria
GPX85_RS05095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPX85_RS05100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPX85_RS05105	COG0606	chelatase, subunit chli
GPX85_RS05115	COG3978	acetolactate synthase activity
GPX85_RS05120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPX85_RS05125	COG0129	dihydroxy-acid dehydratase activity
GPX85_RS05135	COG0604	alcohol dehydrogenase
GPX85_RS05150	COG2119	membrane
GPX85_RS05155	COG0752	glycyl-tRNA synthetase alpha subunit
GPX85_RS05160	COG0751	glycine-tRNA ligase activity
GPX85_RS05165	COG3977	Valine--pyruvate aminotransferase
GPX85_RS05170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPX85_RS05175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPX85_RS05180	COG0009	L-threonylcarbamoyladenylate synthase
GPX85_RS05190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPX85_RS05200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPX85_RS05235	COG0583	DNA-binding transcription factor activity
GPX85_RS05240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPX85_RS05245	COG2960	long-chain fatty acid transporting porin activity
GPX85_RS05250	COG1943	Transposase
GPX85_RS05255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPX85_RS05260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPX85_RS05295	COG4172	Belongs to the ABC transporter superfamily
GPX85_RS05300	COG0747	negative chemotaxis
GPX85_RS05310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPX85_RS05325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPX85_RS05330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPX85_RS05340	COG0210	DNA helicase
GPX85_RS05345	COG1280	lysine exporter protein (LysE YggA)
GPX85_RS05350	COG2962	Rard protein
GPX85_RS05355	COG0514	ATP-dependent DNA helicase (RecQ)
GPX85_RS05370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPX85_RS05375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX85_RS05375	COG1263	PTS System
GPX85_RS05390	COG2084	Dehydrogenase
GPX85_RS05415	COG2211	Major facilitator Superfamily
GPX85_RS05420	COG2211	Major facilitator Superfamily
GPX85_RS05425	COG1501	Belongs to the glycosyl hydrolase 31 family
GPX85_RS05440	COG1228	amidohydrolase
GPX85_RS05445	COG0612	Peptidase, M16
GPX85_RS05450	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GPX85_RS05460	COG1566	PFAM secretion protein HlyD family protein
GPX85_RS05465	COG1289	transmembrane transporter activity
GPX85_RS05490	COG3012	SEC-C Motif Domain Protein
GPX85_RS05500	COG1561	YicC-like family, N-terminal region
GPX85_RS05515	COG2223	nitrite transmembrane transporter activity
GPX85_RS05520	COG3279	Response regulator of the LytR AlgR family
GPX85_RS05525	COG3275	phosphorelay sensor kinase activity
GPX85_RS05530	COG1560	Kdo2-lipid A biosynthetic process
GPX85_RS05535	COG1309	transcriptional regulator
GPX85_RS05540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPX85_RS05555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPX85_RS05570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPX85_RS05575	COG0859	PFAM glycosyl transferase family 9
GPX85_RS05580	COG0463	Glycosyl transferase, family 2
GPX85_RS05590	COG0859	PFAM glycosyl transferase family 9
GPX85_RS05595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPX85_RS05600	COG3642	lipopolysaccharide core region biosynthetic process
GPX85_RS05605	COG1519	Transferase
GPX85_RS05610	COG0859	PFAM glycosyl transferase family 9
GPX85_RS05630	COG0438	transferase activity, transferring glycosyl groups
GPX85_RS05645	COG1560	Kdo2-lipid A biosynthetic process
GPX85_RS05665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPX85_RS05675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPX85_RS05715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPX85_RS05735	COG0110	maltose O-acetyltransferase activity
GPX85_RS05740	COG2244	polysaccharide biosynthetic process
GPX85_RS05770	COG5433	transposase activity
GPX85_RS05780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPX85_RS05785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPX85_RS05815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPX85_RS05865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPX85_RS05870	COG0463	Glycosyl transferase, family 2
GPX85_RS05895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPX85_RS05900	COG0463	Glycosyl transferase, family 2
GPX85_RS05915	COG0463	Glycosyl transferase, family 2
GPX85_RS05925	COG0438	transferase activity, transferring glycosyl groups
GPX85_RS05925	COG1216	Glycosyl transferase, family 2
GPX85_RS05930	COG0438	transferase activity, transferring glycosyl groups
GPX85_RS05930	COG1216	Glycosyl transferase, family 2
GPX85_RS05955	COG2271	Major facilitator Superfamily
GPX85_RS05965	COG2197	response regulator
GPX85_RS05975	COG2197	response regulator
GPX85_RS05980	COG3851	Histidine kinase
GPX85_RS05985	COG2271	Major facilitator Superfamily
GPX85_RS05990	COG1840	ABC-type Fe3 transport system, periplasmic component
GPX85_RS06000	COG3842	ATPase activity
GPX85_RS06005	COG0840	transmembrane signaling receptor activity
GPX85_RS06010	COG3068	Protein conserved in bacteria
GPX85_RS06015	COG0668	transmembrane transport
GPX85_RS06020	COG1253	flavin adenine dinucleotide binding
GPX85_RS06025	COG0776	regulation of translation
GPX85_RS06055	COG3710	Transcriptional regulator
GPX85_RS06060	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPX85_RS06065	COG0531	amino acid
GPX85_RS06070	COG1982	Orn Lys Arg decarboxylase major
GPX85_RS06075	COG1482	cell wall glycoprotein biosynthetic process
GPX85_RS06080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX85_RS06080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX85_RS06080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX85_RS06085	COG2207	Transcriptional regulator
GPX85_RS06095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPX85_RS06105	COG0583	DNA-binding transcription factor activity
GPX85_RS06110	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPX85_RS06125	COG0439	Biotin carboxylase
GPX85_RS06130	COG0511	ligase activity, forming carbon-carbon bonds
GPX85_RS06135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPX85_RS06140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPX85_RS06155	COG2814	Major facilitator Superfamily
GPX85_RS06160	COG0784	Response regulator, receiver
GPX85_RS06160	COG2198	Histidine kinase
GPX85_RS06160	COG2205	protein histidine kinase activity
GPX85_RS06165	COG0248	Ppx GppA phosphatase
GPX85_RS06170	COG0513	Belongs to the DEAD box helicase family
GPX85_RS06175	COG3118	belongs to the thioredoxin family
GPX85_RS06180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPX85_RS06185	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPX85_RS06230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPX85_RS06240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPX85_RS06250	COG1072	(Pantothenic acid kinase))
GPX85_RS06280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPX85_RS06290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPX85_RS06300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPX85_RS06310	COG0085	RNA polymerase activity
GPX85_RS06315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPX85_RS06320	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPX85_RS06325	COG2816	NAD+ diphosphatase activity
GPX85_RS06330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPX85_RS06345	COG4942	peptidase
GPX85_RS06350	COG0513	Belongs to the DEAD box helicase family
GPX85_RS06355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPX85_RS06360	COG0471	metal ion transport
GPX85_RS06370	COG1162	GTPase activity
GPX85_RS06425	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPX85_RS06430	COG0802	atpase or kinase
GPX85_RS06435	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPX85_RS06440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPX85_RS06445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPX85_RS06455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPX85_RS06460	COG0330	HflC and HflK could
GPX85_RS06465	COG0330	HflC and HflK could
GPX85_RS06470	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPX85_RS06475	COG2900	Belongs to the SlyX family
GPX85_RS06485	COG0545	Peptidyl-prolyl cis-trans isomerase
GPX85_RS06490	COG2964	Protein conserved in bacteria
GPX85_RS06495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPX85_RS06500	COG2923	Belongs to the DsrF TusC family
GPX85_RS06505	COG2168	tRNA wobble position uridine thiolation
GPX85_RS06515	COG0049	tRNA binding
GPX85_RS06520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPX85_RS06530	COG0360	Binds together with S18 to 16S ribosomal RNA
GPX85_RS06550	COG0305	Participates in initiation and elongation during chromosome replication
GPX85_RS06555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPX85_RS06560	COG0166	Belongs to the GPI family
GPX85_RS06570	COG0735	belongs to the Fur family
GPX85_RS06575	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPX85_RS06580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPX85_RS06605	COG0175	sulfate reduction
GPX85_RS06650	COG0527	aspartate kinase activity
GPX85_RS06655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPX85_RS06665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPX85_RS06680	COG0629	single-stranded DNA binding
GPX85_RS06685	COG2199	diguanylate cyclase activity
GPX85_RS06685	COG2200	EAL domain
GPX85_RS06705	COG1450	Type ii and iii secretion system protein
GPX85_RS06710	COG3409	Peptidoglycan-binding domain 1 protein
GPX85_RS06710	COG3267	Type II secretory pathway component ExeA
GPX85_RS06725	COG1459	type II secretion system
GPX85_RS06765	COG1077	Cell shape determining protein MreB Mrl
GPX85_RS06770	COG1792	Involved in formation and maintenance of cell shape
GPX85_RS06775	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPX85_RS06785	COG1530	ribonuclease E activity
GPX85_RS06790	COG3164	Protein of unknown function
GPX85_RS06795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPX85_RS06800	COG0312	modulator of DNA gyrase
GPX85_RS06820	COG0589	response to stress
GPX85_RS06840	COG0039	L-malate dehydrogenase activity
GPX85_RS06845	COG0531	amino acid
GPX85_RS06850	COG0142	geranyltranstransferase activity
GPX85_RS06855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPX85_RS06870	COG2966	Psort location CytoplasmicMembrane, score
GPX85_RS06890	COG2967	ApaG domain
GPX85_RS06895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPX85_RS06900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPX85_RS06905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPX85_RS06910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPX85_RS06915	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPX85_RS06965	COG0741	lytic transglycosylase activity
GPX85_RS06970	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPX85_RS06975	COG1194	a g-specific adenine glycosylase
GPX85_RS06980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPX85_RS06990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPX85_RS06995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPX85_RS07000	COG1872	DUF167
GPX85_RS07005	COG0762	integral membrane protein
GPX85_RS07010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPX85_RS07015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPX85_RS07030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPX85_RS07035	COG1678	Uncharacterized ACR, COG1678
GPX85_RS07040	COG0189	ligase activity
GPX85_RS07045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPX85_RS07050	COG2356	endonuclease I
GPX85_RS07055	COG3091	SprT-like family
GPX85_RS07065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPX85_RS07070	COG0583	DNA-binding transcription factor activity
GPX85_RS07075	COG4771	TonB-dependent receptor
GPX85_RS07080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPX85_RS07085	COG0126	phosphoglycerate kinase activity
GPX85_RS07090	COG0191	fructose-bisphosphate aldolase activity
GPX85_RS07095	COG0668	transmembrane transport
GPX85_RS07105	COG0583	DNA-binding transcription factor activity
GPX85_RS07115	COG0745	RESPONSE REGULATOR receiver
GPX85_RS07115	COG3706	GGDEF domain
GPX85_RS07120	COG0469	pyruvate kinase activity
GPX85_RS07125	COG1349	DNA-binding transcription factor activity
GPX85_RS07155	COG3344	reverse transcriptase
GPX85_RS07160	COG2194	sulfuric ester hydrolase activity
GPX85_RS07165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPX85_RS07175	COG0745	RESPONSE REGULATOR receiver
GPX85_RS07180	COG5002	protein histidine kinase activity
GPX85_RS07225	COG0584	glycerophosphoryl diester phosphodiesterase
GPX85_RS07230	COG2221	Nitrite and sulphite reductase 4Fe-4S
GPX85_RS07230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPX85_RS07240	COG0437	4 iron, 4 sulfur cluster binding
GPX85_RS07245	COG3302	dmso reductase anchor subunit
GPX85_RS07250	COG3381	protein complex oligomerization
GPX85_RS07255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPX85_RS07280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPX85_RS07285	COG0358	DNA primase activity
GPX85_RS07290	COG1610	YqeY-like protein
GPX85_RS07300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPX85_RS07305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPX85_RS07310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPX85_RS07315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPX85_RS07325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPX85_RS07330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPX85_RS07335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPX85_RS07355	COG4942	peptidase
GPX85_RS07355	COG1388	LysM domain
GPX85_RS07360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPX85_RS07365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPX85_RS07385	COG4208	sulfate ABC transporter
GPX85_RS07390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPX85_RS07395	COG1546	Belongs to the CinA family
GPX85_RS07400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPX85_RS07415	COG0527	aspartate kinase activity
GPX85_RS07470	COG5016	pyruvate
GPX85_RS07470	COG0511	ligase activity, forming carbon-carbon bonds
GPX85_RS07475	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPX85_RS07480	COG2130	NADP-dependent
GPX85_RS07485	COG1238	metal cluster binding
GPX85_RS07490	COG0612	Peptidase, M16
GPX85_RS07495	COG2918	glutathione biosynthetic process
GPX85_RS07500	COG1854	S-ribosylhomocysteine lyase activity
GPX85_RS07505	COG4536	flavin adenine dinucleotide binding
GPX85_RS07510	COG4137	Cytochrome C assembly protein
GPX85_RS07515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPX85_RS07525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPX85_RS07530	COG0336	Belongs to the RNA methyltransferase TrmD family
GPX85_RS07535	COG0335	large ribosomal subunit rRNA binding
GPX85_RS07545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPX85_RS07555	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPX85_RS07560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPX85_RS07565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPX85_RS07570	COG0625	glutathione transferase activity
GPX85_RS07575	COG2969	positive regulation of protein catabolic process
GPX85_RS07580	COG2823	Periplasmic or secreted lipoprotein
GPX85_RS07585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPX85_RS07595	COG3107	peptidoglycan biosynthetic process
GPX85_RS07600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPX85_RS07610	COG0275	rRNA processing
GPX85_RS07615	COG3116	cell division
GPX85_RS07620	COG0768	penicillin binding
GPX85_RS07625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPX85_RS07630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPX85_RS07640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPX85_RS07645	COG0772	Belongs to the SEDS family
GPX85_RS07650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPX85_RS07655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPX85_RS07660	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPX85_RS07665	COG0849	cell division
GPX85_RS07670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPX85_RS07675	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPX85_RS07680	COG0653	protein targeting
GPX85_RS07685	COG0494	nUDIX hydrolase
GPX85_RS07690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPX85_RS07695	COG0505	Belongs to the CarA family
GPX85_RS07705	COG0730	response to heat
GPX85_RS07710	COG0583	DNA-binding transcription factor activity
GPX85_RS07715	COG2860	membrane
GPX85_RS07730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPX85_RS07745	COG0067	glutamate synthase
GPX85_RS07745	COG0069	glutamate synthase activity
GPX85_RS07745	COG0070	glutamate synthase
GPX85_RS07750	COG1242	4 iron, 4 sulfur cluster binding
GPX85_RS07755	COG0784	Response regulator, receiver
GPX85_RS07755	COG5002	protein histidine kinase activity
GPX85_RS07755	COG2198	Histidine kinase
GPX85_RS07765	COG0745	RESPONSE REGULATOR receiver
GPX85_RS07775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPX85_RS07790	COG0083	homoserine kinase activity
GPX85_RS07795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPX85_RS07805	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPX85_RS07810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPX85_RS07830	COG3022	response to hydroperoxide
GPX85_RS07840	COG0084	hydrolase, TatD family'
GPX85_RS07845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPX85_RS07850	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPX85_RS07855	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPX85_RS07860	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPX85_RS07865	COG0813	purine-nucleoside phosphorylase activity
GPX85_RS07875	COG0560	Phosphoserine phosphatase
GPX85_RS07885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPX85_RS07890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPX85_RS07905	COG2059	Chromate
GPX85_RS07920	COG0569	domain protein
GPX85_RS07920	COG0189	ligase activity
GPX85_RS07930	COG2171	N-acyltransferase activity
GPX85_RS07935	COG3141	response to X-ray
GPX85_RS07940	COG0583	DNA-binding transcription factor activity
GPX85_RS07950	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPX85_RS07960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPX85_RS07965	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPX85_RS07965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPX85_RS07975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPX85_RS07980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPX85_RS07985	COG2166	iron-sulfur cluster assembly
GPX85_RS07990	COG0693	protein deglycase activity
GPX85_RS07995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPX85_RS08000	COG0737	Belongs to the 5'-nucleotidase family
GPX85_RS08005	COG3248	Nucleoside-binding outer membrane protein
GPX85_RS08015	COG1595	DNA-templated transcription, initiation
GPX85_RS08035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPX85_RS08050	COG0745	RESPONSE REGULATOR receiver
GPX85_RS08055	COG5002	protein histidine kinase activity
GPX85_RS08065	COG0248	Ppx GppA phosphatase
GPX85_RS08070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPX85_RS08075	COG0573	inorganic phosphate transmembrane transporter activity
GPX85_RS08080	COG0581	inorganic phosphate transmembrane transporter activity
GPX85_RS08085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPX85_RS08090	COG0704	Plays a role in the regulation of phosphate uptake
GPX85_RS08100	COG0450	alkyl hydroperoxide reductase
GPX85_RS08105	COG0583	DNA-binding transcription factor activity
GPX85_RS08110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPX85_RS08120	COG0517	IMP dehydrogenase activity
GPX85_RS08125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPX85_RS08135	COG1862	Preprotein translocase
GPX85_RS08140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPX85_RS08145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPX85_RS08150	COG0483	inositol monophosphate 1-phosphatase activity
GPX85_RS08155	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPX85_RS08160	COG1959	2 iron, 2 sulfur cluster binding
GPX85_RS08165	COG1104	cysteine desulfurase activity
GPX85_RS08170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPX85_RS08175	COG0105	UTP biosynthetic process
GPX85_RS08185	COG1426	Protein conserved in bacteria
GPX85_RS08190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPX85_RS08195	COG0124	histidyl-tRNA synthetase
GPX85_RS08200	COG2976	Protein conserved in bacteria
GPX85_RS08205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPX85_RS08210	COG1160	GTP binding
GPX85_RS08220	COG1570	exodeoxyribonuclease VII activity
GPX85_RS08225	COG0516	GMP reductase activity
GPX85_RS08225	COG0517	IMP dehydrogenase activity
GPX85_RS08240	COG0667	Aldo Keto reductase
GPX85_RS08255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPX85_RS08260	COG1584	GPR1 FUN34 yaaH family protein
GPX85_RS08275	COG0700	Nucleoside recognition
GPX85_RS08280	COG3366	ferrous iron transmembrane transporter activity
GPX85_RS08290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPX85_RS08295	COG0583	DNA-binding transcription factor activity
GPX85_RS08310	COG2239	Acts as a magnesium transporter
GPX85_RS08320	COG2239	Acts as a magnesium transporter
GPX85_RS08345	COG1204	response to ionizing radiation
GPX85_RS08385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPX85_RS08410	COG0840	transmembrane signaling receptor activity
GPX85_RS08415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPX85_RS08430	COG1464	Belongs to the NlpA lipoprotein family
GPX85_RS08470	COG2867	negative regulation of translational initiation
GPX85_RS08475	COG2914	Belongs to the UPF0125 (RnfH) family
GPX85_RS08480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPX85_RS08485	COG0497	DNA recombination
GPX85_RS08495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPX85_RS08500	COG0443	Heat shock 70 kDa protein
GPX85_RS08505	COG0484	heat shock protein binding
GPX85_RS08510	COG0513	Belongs to the DEAD box helicase family
GPX85_RS08550	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GPX85_RS08560	COG0583	DNA-binding transcription factor activity
GPX85_RS08565	COG0590	tRNA wobble adenosine to inosine editing
GPX85_RS08570	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPX85_RS08575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPX85_RS08575	COG0047	phosphoribosylformylglycinamidine synthase activity
GPX85_RS08595	COG0442	prolyl-tRNA aminoacylation
GPX85_RS08600	COG1720	tRNA m6t6A37 methyltransferase activity
GPX85_RS08610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPX85_RS08615	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPX85_RS08620	COG1671	Belongs to the UPF0178 family
GPX85_RS08645	COG3098	single-species biofilm formation
GPX85_RS08650	COG0564	pseudouridine synthase activity
GPX85_RS08655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPX85_RS08660	COG0142	geranyltranstransferase activity
GPX85_RS08665	COG1722	exodeoxyribonuclease VII activity
GPX85_RS08670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPX85_RS08680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPX85_RS08680	COG0301	tRNA thio-modification
GPX85_RS08685	COG0583	DNA-binding transcription factor activity
GPX85_RS08695	COG2363	Small membrane protein
GPX85_RS08705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPX85_RS08710	COG1611	Belongs to the LOG family
GPX85_RS08715	COG0745	RESPONSE REGULATOR receiver
GPX85_RS08715	COG3706	GGDEF domain
GPX85_RS08725	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPX85_RS08725	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPX85_RS08735	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPX85_RS08740	COG1464	Belongs to the NlpA lipoprotein family
GPX85_RS08745	COG2011	ABC-type metal ion transport system permease component
GPX85_RS08750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPX85_RS08755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPX85_RS08760	COG1609	Transcriptional regulator
GPX85_RS08765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX85_RS08765	COG1263	PTS System
GPX85_RS08770	COG0366	Alpha amylase catalytic
GPX85_RS08800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPX85_RS08810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPX85_RS08825	COG2921	Belongs to the UPF0250 family
GPX85_RS08830	COG1686	Belongs to the peptidase S11 family
GPX85_RS08835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPX85_RS08840	COG0772	Belongs to the SEDS family
GPX85_RS08850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPX85_RS08855	COG0799	negative regulation of ribosome biogenesis
GPX85_RS08860	COG1466	dna polymerase III delta subunit
GPX85_RS08865	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPX85_RS08870	COG0495	leucyl-tRNA aminoacylation
GPX85_RS08875	COG2888	peptidyl-tyrosine sulfation
GPX85_RS08880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPX85_RS08885	COG4535	Mg2 and Co2 transporter CorC
GPX85_RS08890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPX85_RS08895	COG1702	phosphate starvation-inducible protein PhoH
GPX85_RS08900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPX85_RS08905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPX85_RS08910	COG1943	Transposase
GPX85_RS08915	COG2190	(PTS) system
GPX85_RS08925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX85_RS08935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPX85_RS08940	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPX85_RS08945	COG3115	cell septum assembly
GPX85_RS08950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPX85_RS08965	COG0789	Transcriptional regulator
GPX85_RS08970	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPX85_RS08975	COG0330	HflC and HflK could
GPX85_RS08980	COG3118	belongs to the thioredoxin family
GPX85_RS08990	COG0300	oxidoreductase activity
GPX85_RS08995	COG1090	epimerase
GPX85_RS09000	COG0622	Phosphoesterase
GPX85_RS09015	COG3710	Transcriptional regulator
GPX85_RS09020	COG0326	Molecular chaperone. Has ATPase activity
GPX85_RS09025	COG0563	adenylate kinase activity
GPX85_RS09030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPX85_RS09045	COG0250	Participates in transcription elongation, termination and antitermination
GPX85_RS09050	COG0367	asparagine synthase
GPX85_RS09055	COG1940	carbohydrate kinase activity
GPX85_RS09055	COG1846	Transcriptional regulator
GPX85_RS09060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPX85_RS09065	COG2190	(PTS) system
GPX85_RS09065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX85_RS09065	COG1263	PTS System
GPX85_RS09070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPX85_RS09080	COG0101	tRNA pseudouridine synthase activity
GPX85_RS09085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPX85_RS09090	COG0285	dihydrofolate synthase activity
GPX85_RS09095	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPX85_RS09100	COG1286	toxin biosynthetic process
GPX85_RS09105	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPX85_RS09110	COG2056	Na+-H+ antiporter family
GPX85_RS09125	COG0346	lactoylglutathione lyase activity
GPX85_RS09130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPX85_RS09135	COG4660	Part of a membrane complex involved in electron transport
GPX85_RS09140	COG4659	FMN binding
GPX85_RS09145	COG4658	electron transport chain
GPX85_RS09150	COG4656	Part of a membrane complex involved in electron transport
GPX85_RS09155	COG2878	Part of a membrane complex involved in electron transport
GPX85_RS09160	COG4657	Part of a membrane complex involved in electron transport
GPX85_RS09170	COG4232	protein-disulfide reductase activity
GPX85_RS09175	COG3118	belongs to the thioredoxin family
GPX85_RS09185	COG1301	dicarboxylic acid transport
GPX85_RS09195	COG0556	nucleotide-excision repair
GPX85_RS09200	COG2204	response regulator
GPX85_RS09205	COG2198	Histidine kinase
GPX85_RS09215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPX85_RS09220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPX85_RS09230	COG0840	transmembrane signaling receptor activity
GPX85_RS09235	COG2200	EAL domain
GPX85_RS09260	COG1760	l-serine dehydratase
GPX85_RS09265	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPX85_RS09270	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPX85_RS09280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPX85_RS09285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPX85_RS09290	COG0776	regulation of translation
GPX85_RS09295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPX85_RS09305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPX85_RS09310	COG0539	negative regulation of cytoplasmic translation
GPX85_RS09320	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPX85_RS09325	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPX85_RS09350	COG0686	Belongs to the AlaDH PNT family
GPX85_RS09355	COG1522	sequence-specific DNA binding
GPX85_RS09360	COG1674	ftsk spoiiie
GPX85_RS09380	COG0109	protoheme IX farnesyltransferase activity
GPX85_RS09385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPX85_RS09390	COG1845	cytochrome c oxidase, subunit III
GPX85_RS09395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPX85_RS09400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPX85_RS09410	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPX85_RS09415	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPX85_RS09420	COG2186	Transcriptional regulator
GPX85_RS09430	COG0840	transmembrane signaling receptor activity
GPX85_RS09435	COG0537	adenosine 5'-monophosphoramidase activity
GPX85_RS09470	COG1530	ribonuclease E activity
GPX85_RS09475	COG0564	pseudouridine synthase activity
GPX85_RS09480	COG0424	maF-like protein
GPX85_RS09485	COG1399	metal-binding, possibly nucleic acid-binding protein
GPX85_RS09495	COG0416	fatty acid biosynthetic process
GPX85_RS09500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPX85_RS09505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPX85_RS09515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPX85_RS09520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPX85_RS09525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPX85_RS09530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPX85_RS09535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPX85_RS09545	COG0084	hydrolase, TatD family'
GPX85_RS09550	COG1263	PTS System
GPX85_RS09550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX85_RS09565	COG0733	neurotransmitter:sodium symporter activity
GPX85_RS09580	COG4667	esterase of the alpha-beta hydrolase superfamily
GPX85_RS09585	COG0469	pyruvate kinase activity
GPX85_RS09590	COG1940	carbohydrate kinase activity
GPX85_RS09595	COG0835	chemotaxis
GPX85_RS09595	COG0784	Response regulator, receiver
GPX85_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
GPX85_RS09605	COG0616	signal peptide processing
GPX85_RS09620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPX85_RS09625	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPX85_RS09645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX85_RS09650	COG0436	Aminotransferase
GPX85_RS09655	COG1169	isochorismate synthase
GPX85_RS09665	COG0596	Alpha beta hydrolase
GPX85_RS09675	COG1441	menaquinone biosynthetic process
GPX85_RS09705	COG3015	lipoprotein NlpE involved in copper resistance
GPX85_RS09715	COG1522	sequence-specific DNA binding
GPX85_RS09720	COG1946	Acyl-CoA thioesterase
GPX85_RS09790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPX85_RS09795	COG0385	Bile acid
GPX85_RS09800	COG0318	PFAM AMP-dependent synthetase and ligase
GPX85_RS09825	COG2814	Major facilitator Superfamily
GPX85_RS09830	COG0488	(ABC) transporter
GPX85_RS09835	COG0366	Alpha amylase catalytic
GPX85_RS09845	COG1280	lysine exporter protein (LysE YggA)
GPX85_RS09855	COG1629	transport
GPX85_RS09885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPX85_RS09910	COG0646	methionine synthase
GPX85_RS09910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPX85_RS09915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPX85_RS09920	COG0366	Alpha amylase catalytic
GPX85_RS09935	COG1609	Transcriptional regulator
GPX85_RS09940	COG2723	6-phospho-beta-galactosidase activity
GPX85_RS09950	COG1263	PTS System
GPX85_RS09950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPX85_RS09960	COG1621	beta-fructofuranosidase activity
GPX85_RS09965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX85_RS09980	COG0601	transmembrane transport
GPX85_RS09985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPX85_RS10015	COG4964	Belongs to the GSP D family
GPX85_RS10075	COG0435	Glutathione S-transferase
GPX85_RS10080	COG0280	phosphate acetyltransferase
GPX85_RS10080	COG0857	belongs to the CobB CobQ family
GPX85_RS10085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPX85_RS10090	COG3092	negative regulation of chromosome organization
GPX85_RS10100	COG0653	protein targeting
GPX85_RS10105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPX85_RS10110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPX85_RS10115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPX85_RS10125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPX85_RS10130	COG0156	8-amino-7-oxononanoate synthase activity
GPX85_RS10135	COG2226	methyltransferase
GPX85_RS10140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPX85_RS10150	COG2350	Protein conserved in bacteria
GPX85_RS10155	COG1607	acyl-coa hydrolase
GPX85_RS10165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPX85_RS10175	COG0133	tryptophan synthase activity
GPX85_RS10180	COG0135	phosphoribosylanthranilate isomerase activity
GPX85_RS10180	COG0134	indole-3-glycerol-phosphate synthase activity
GPX85_RS10185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPX85_RS10190	COG0512	Glutamine amidotransferase of anthranilate synthase
GPX85_RS10195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPX85_RS10205	COG0613	PHP domain protein
GPX85_RS10210	COG0009	L-threonylcarbamoyladenylate synthase
GPX85_RS10215	COG1187	pseudouridine synthase activity
GPX85_RS10220	COG1943	Transposase
GPX85_RS10230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPX85_RS10235	COG4988	ABC transporter
GPX85_RS10240	COG0492	ferredoxin-NADP+ reductase activity
GPX85_RS10260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPX85_RS10270	COG2949	membrane
GPX85_RS10280	COG0281	malic enzyme
GPX85_RS10290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPX85_RS10310	COG2885	chlorophyll binding
GPX85_RS10325	COG0247	lactate metabolic process
GPX85_RS10325	COG0277	FAD linked oxidase domain protein
GPX85_RS10345	COG0415	Belongs to the DNA photolyase family
GPX85_RS10360	COG2986	histidine ammonia-lyase
GPX85_RS10370	COG0010	Belongs to the arginase family
GPX85_RS10375	COG1228	amidohydrolase
GPX85_RS10390	COG3099	Belongs to the UPF0263 family
GPX85_RS10395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPX85_RS10405	COG0814	amino acid
GPX85_RS10410	COG0417	DNA replication proofreading
GPX85_RS10425	COG2197	response regulator
GPX85_RS10430	COG0322	excinuclease ABC activity
GPX85_RS10475	COG0072	phenylalanine-tRNA ligase activity
GPX85_RS10475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPX85_RS10505	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPX85_RS10510	COG5001	Diguanylate cyclase
GPX85_RS10515	COG0295	cytidine deaminase activity
GPX85_RS10520	COG1346	cytolysis
GPX85_RS10545	COG3527	Alpha-acetolactate decarboxylase
GPX85_RS10570	COG0583	DNA-binding transcription factor activity
GPX85_RS10580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPX85_RS10585	COG1943	Transposase
GPX85_RS10590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPX85_RS10595	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPX85_RS10605	COG3842	ATPase activity
GPX85_RS10610	COG1840	ABC-type Fe3 transport system, periplasmic component
GPX85_RS10615	COG0583	DNA-binding transcription factor activity
GPX85_RS10630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPX85_RS10635	COG1061	Type III restriction enzyme res subunit
GPX85_RS10640	COG1187	pseudouridine synthase activity
GPX85_RS10645	COG2814	Major facilitator Superfamily
GPX85_RS10655	COG5380	lipid catabolic process
GPX85_RS10660	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPX85_RS10665	COG0702	epimerase
GPX85_RS10670	COG0534	Mate efflux family protein
GPX85_RS10675	COG4181	ATPase activity
GPX85_RS10690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPX85_RS10700	COG2111	Na H antiporter
GPX85_RS10715	COG1863	multisubunit Na H antiporter MnhE subunit
GPX85_RS10720	COG2212	antiporter activity
GPX85_RS10725	COG1320	monovalent cation:proton antiporter activity
GPX85_RS10735	COG1748	Saccharopine dehydrogenase
GPX85_RS10740	COG0019	diaminopimelate decarboxylase activity
GPX85_RS10775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPX85_RS10780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPX85_RS10795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPX85_RS10800	COG2989	Protein conserved in bacteria
GPX85_RS10805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPX85_RS10820	COG1846	Transcriptional regulator
GPX85_RS10825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPX85_RS10830	COG0840	transmembrane signaling receptor activity
GPX85_RS10835	COG2176	DNA-directed DNA polymerase activity
GPX85_RS10840	COG0517	IMP dehydrogenase activity
GPX85_RS10850	COG1448	Aminotransferase
GPX85_RS10855	COG0017	Asparaginyl-tRNA synthetase
GPX85_RS10860	COG0720	synthase
GPX85_RS10865	COG1538	Outer membrane efflux protein
GPX85_RS10875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPX85_RS10880	COG1760	l-serine dehydratase
GPX85_RS10885	COG0814	amino acid
GPX85_RS10890	COG0494	nUDIX hydrolase
GPX85_RS10895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPX85_RS10910	COG3106	COG3106 Predicted ATPase
GPX85_RS10915	COG3768	UPF0283 membrane protein
GPX85_RS10920	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPX85_RS10925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPX85_RS10935	COG5006	permease, DMT superfamily
GPX85_RS10940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPX85_RS10950	COG0471	metal ion transport
GPX85_RS10955	COG4191	Histidine kinase
GPX85_RS10955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX85_RS10980	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPX85_RS10985	COG0372	Belongs to the citrate synthase family
GPX85_RS10995	COG2828	Protein conserved in bacteria
GPX85_RS11000	COG3158	transport of potassium into the cell
GPX85_RS11035	COG2171	N-acyltransferase activity
GPX85_RS11040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPX85_RS11055	COG0003	Pfam Anion-transporting ATPase
GPX85_RS11060	COG1280	lysine exporter protein (LysE YggA)
GPX85_RS11065	COG1115	amino acid carrier protein
GPX85_RS11080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPX85_RS11100	COG2996	Protein conserved in bacteria
GPX85_RS11105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPX85_RS11105	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPX85_RS11110	COG3008	intermembrane lipid transfer
GPX85_RS11115	COG2995	paraquat-inducible protein a
GPX85_RS11120	COG1132	(ABC) transporter
GPX85_RS11125	COG1956	GAF domain-containing protein
GPX85_RS11130	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPX85_RS11145	COG0308	aminopeptidase N
GPX85_RS11155	COG2902	Dehydrogenase
GPX85_RS11160	COG0167	dihydroorotate dehydrogenase activity
GPX85_RS11170	COG0116	Belongs to the methyltransferase superfamily
GPX85_RS11170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPX85_RS11175	COG0488	(ABC) transporter
GPX85_RS11190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPX85_RS11195	COG1067	ATP-dependent peptidase activity
GPX85_RS11200	COG3120	sequence-specific DNA binding
GPX85_RS11210	COG0784	Response regulator, receiver
GPX85_RS11210	COG2205	protein histidine kinase activity
GPX85_RS11225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPX85_RS11230	COG0589	response to stress
GPX85_RS11250	COG3842	ATPase activity
GPX85_RS11255	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPX85_RS11260	COG1177	transmembrane transport
GPX85_RS11265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPX85_RS11270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPX85_RS11290	COG0437	4 iron, 4 sulfur cluster binding
GPX85_RS11295	COG0243	molybdopterin cofactor binding
GPX85_RS11295	COG3383	formate dehydrogenase (NAD+) activity
GPX85_RS11325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPX85_RS11330	COG4191	Histidine kinase
GPX85_RS11335	COG2204	response regulator
GPX85_RS11345	COG4662	Binding-protein-dependent transport system inner membrane component
GPX85_RS11355	COG0746	molybdenum cofactor guanylyltransferase activity
GPX85_RS11360	COG0303	'Molybdopterin
GPX85_RS11385	COG0791	NLP P60 protein
GPX85_RS11400	COG0393	Putative heavy-metal-binding
GPX85_RS11405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX85_RS11405	COG4191	Histidine kinase
GPX85_RS11420	COG3437	response regulator, receiver
GPX85_RS11420	COG0784	Response regulator, receiver
GPX85_RS11430	COG0307	riboflavin synthase, alpha
GPX85_RS11435	COG0534	Mate efflux family protein
GPX85_RS11460	COG0848	biopolymer transport protein
GPX85_RS11465	COG0811	peptide transport
GPX85_RS11470	COG0811	peptide transport
GPX85_RS11480	COG2201	protein-glutamate methylesterase activity
GPX85_RS11490	COG0835	chemotaxis
GPX85_RS11500	COG0643	Histidine kinase
GPX85_RS11500	COG2198	Histidine kinase
GPX85_RS11510	COG0745	RESPONSE REGULATOR receiver
GPX85_RS11515	COG0840	transmembrane signaling receptor activity
GPX85_RS11530	COG1175	transmembrane transport
GPX85_RS11535	COG0395	ABC-type sugar transport system, permease component
GPX85_RS11540	COG3842	ATPase activity
GPX85_RS11545	COG0625	glutathione transferase activity
GPX85_RS11555	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPX85_RS11565	COG2200	EAL domain
GPX85_RS11575	COG2814	Major facilitator Superfamily
GPX85_RS11580	COG0583	DNA-binding transcription factor activity
GPX85_RS11590	COG1643	Atp-dependent helicase
GPX85_RS11605	COG0840	transmembrane signaling receptor activity
GPX85_RS11620	COG0443	Heat shock 70 kDa protein
GPX85_RS11630	COG5002	protein histidine kinase activity
GPX85_RS11645	COG1132	(ABC) transporter
GPX85_RS11650	COG1132	(ABC) transporter
GPX85_RS11665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPX85_RS11670	COG0602	queuosine metabolic process
GPX85_RS11675	COG0561	phosphatase activity
GPX85_RS11685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX85_RS11690	COG0670	Belongs to the BI1 family
GPX85_RS11695	COG2920	part of a sulfur-relay system
GPX85_RS11700	COG1254	Belongs to the acylphosphatase family
GPX85_RS11705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPX85_RS11710	COG1294	oxidase, subunit
GPX85_RS11715	COG1271	oxidase subunit
GPX85_RS11720	COG0415	Belongs to the DNA photolyase family
GPX85_RS11740	COG0745	RESPONSE REGULATOR receiver
GPX85_RS11745	COG2205	protein histidine kinase activity
GPX85_RS11760	COG3345	alpha-galactosidase
GPX85_RS11780	COG1203	CRISPR-associated helicase, Cas3
GPX85_RS11785	COG1518	maintenance of DNA repeat elements
GPX85_RS11790	COG3290	protein histidine kinase activity
GPX85_RS11800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPX85_RS11810	COG3457	Alanine racemase
GPX85_RS11820	COG0444	Belongs to the ABC transporter superfamily
GPX85_RS11835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPX85_RS11865	COG0835	chemotaxis
GPX85_RS11865	COG0784	Response regulator, receiver
GPX85_RS11880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPX85_RS11895	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPX85_RS11910	COG1451	nucleotide metabolic process
GPX85_RS11920	COG0583	DNA-binding transcription factor activity
GPX85_RS11945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPX85_RS11950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPX85_RS11960	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPX85_RS11965	COG4139	cobalamin transport
GPX85_RS11970	COG2988	succinylglutamate desuccinylase activity
GPX85_RS11990	COG0814	amino acid
GPX85_RS12000	COG3313	Fe-S protein
GPX85_RS12010	COG4134	Bacterial extracellular solute-binding protein
GPX85_RS12015	COG4135	transport system, permease component
GPX85_RS12020	COG4136	ATPase activity
GPX85_RS12025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPX85_RS12030	COG0564	pseudouridine synthase activity
GPX85_RS12035	COG0733	neurotransmitter:sodium symporter activity
GPX85_RS12050	COG0519	Catalyzes the synthesis of GMP from XMP
GPX85_RS12060	COG4168	peptide transport system, permease
GPX85_RS12065	COG4171	peptide transport system, permease
GPX85_RS12075	COG4172	Belongs to the ABC transporter superfamily
GPX85_RS12100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPX85_RS12115	COG1801	Protein of unknown function DUF72
GPX85_RS12120	COG4106	trans-aconitate 2-methyltransferase activity
GPX85_RS12125	COG0500	methyltransferase
GPX85_RS12130	COG4067	protein conserved in archaea
GPX85_RS12130	COG0189	ligase activity
GPX85_RS12140	COG0189	ligase activity
GPX85_RS12155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPX85_RS12160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPX85_RS12165	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPX85_RS12175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPX85_RS12180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPX85_RS12185	COG1609	Transcriptional regulator
GPX85_RS12190	COG3070	regulator of competence-specific genes
GPX85_RS12200	COG0297	glycogen (starch) synthase activity
GPX85_RS12205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPX85_RS12210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPX85_RS12220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPX85_RS12225	COG3134	Outer membrane lipoprotein
GPX85_RS12230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPX85_RS12235	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPX85_RS12240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPX85_RS12245	COG0542	response to heat
GPX85_RS12250	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPX85_RS12255	COG1278	Cold shock
GPX85_RS12270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPX85_RS12270	COG0140	phosphoribosyl-ATP diphosphatase activity
GPX85_RS12275	COG0107	imidazoleglycerol-phosphate synthase activity
GPX85_RS12280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPX85_RS12285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPX85_RS12290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPX85_RS12290	COG0131	Imidazoleglycerol-phosphate dehydratase
GPX85_RS12295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPX85_RS12300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPX85_RS12305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPX85_RS12310	COG1757	Na H antiporter
GPX85_RS12315	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPX85_RS12320	COG1943	Transposase
GPX85_RS12325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPX85_RS12330	COG0482	sulfurtransferase activity
GPX85_RS12335	COG2915	High frequency lysogenization protein hflD homolog
GPX85_RS12340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPX85_RS12360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPX85_RS12375	COG1028	Short-chain dehydrogenase reductase Sdr
GPX85_RS12385	COG0501	Belongs to the peptidase M48B family
GPX85_RS12390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPX85_RS12395	COG0583	DNA-binding transcription factor activity
GPX85_RS12410	COG0612	Peptidase, M16
GPX85_RS12415	COG3344	reverse transcriptase
GPX85_RS12430	COG1032	radical SAM domain protein
GPX85_RS12440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPX85_RS12450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX85_RS12450	COG4191	Histidine kinase
GPX85_RS12450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX85_RS12450	COG4191	Histidine kinase
GPX85_RS12465	COG3070	regulator of competence-specific genes
GPX85_RS12475	COG2431	L-lysine efflux transmembrane transporter activity
GPX85_RS12480	COG0076	glutamate decarboxylase activity
GPX85_RS12485	COG1737	Transcriptional regulator
GPX85_RS12490	COG1454	alcohol dehydrogenase
GPX85_RS12490	COG1012	belongs to the aldehyde dehydrogenase family
GPX85_RS12495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPX85_RS12500	COG2985	domain, Protein
GPX85_RS12500	COG3273	potassium ion transport
GPX85_RS12505	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPX85_RS12535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPX85_RS12540	COG0640	Transcriptional regulator
GPX85_RS12550	COG0573	inorganic phosphate transmembrane transporter activity
GPX85_RS12555	COG0581	inorganic phosphate transmembrane transporter activity
GPX85_RS12560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPX85_RS12570	COG0798	PFAM Bile acid sodium symporter
GPX85_RS12595	COG0798	PFAM Bile acid sodium symporter
GPX85_RS12600	COG0640	Transcriptional regulator
GPX85_RS12605	COG0659	secondary active sulfate transmembrane transporter activity
GPX85_RS12615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPX85_RS12625	COG1131	(ABC) transporter
GPX85_RS12630	COG2188	Transcriptional regulator
GPX85_RS12640	COG2166	iron-sulfur cluster assembly
GPX85_RS12655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPX85_RS12660	COG0719	Fe-S assembly protein
GPX85_RS12665	COG0396	ATPase activity
GPX85_RS12670	COG0719	Fe-S assembly protein
GPX85_RS12675	COG1704	LemA family
GPX85_RS12680	COG0501	Belongs to the peptidase M48B family
GPX85_RS12690	COG0523	cobalamin synthesis protein
GPX85_RS12695	COG3036	rescue of stalled ribosome
GPX85_RS12705	COG2311	Membrane
GPX85_RS12710	COG2311	Membrane
GPX85_RS12755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPX85_RS12760	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPX85_RS12765	COG2885	chlorophyll binding
GPX85_RS12785	COG0811	peptide transport
GPX85_RS12790	COG0824	Thioesterase
GPX85_RS12800	COG4890	Cyd operon protein YbgT
GPX85_RS12805	COG1294	oxidase, subunit
GPX85_RS12810	COG1271	oxidase subunit
GPX85_RS12815	COG2255	four-way junction helicase activity
GPX85_RS12820	COG0632	four-way junction helicase activity
GPX85_RS12825	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPX85_RS12830	COG0215	cysteine-tRNA ligase activity
GPX85_RS12835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPX85_RS12840	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX85_RS12845	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPX85_RS12860	COG1566	PFAM secretion protein HlyD family protein
GPX85_RS12875	COG1199	ATP-dependent helicase activity
GPX85_RS12890	COG0708	Exodeoxyribonuclease III
GPX85_RS12895	COG4160	amino acid transport
GPX85_RS12900	COG4215	(ABC) transporter
GPX85_RS12920	COG1882	Formate acetyltransferase
GPX85_RS12930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPX85_RS12935	COG3013	Belongs to the UPF0304 family
GPX85_RS12945	COG2766	serine protein kinase
GPX85_RS12950	COG2718	Belongs to the UPF0229 family
GPX85_RS12955	COG2719	SpoVR family
GPX85_RS12960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPX85_RS12970	COG1663	tetraacyldisaccharide 4'-kinase activity
GPX85_RS12975	COG1132	(ABC) transporter
GPX85_RS12980	COG0658	competence protein
GPX85_RS12980	COG2333	competence protein COMEC
GPX85_RS12990	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPX85_RS12995	COG1136	(ABC) transporter
GPX85_RS13000	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPX85_RS13010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPX85_RS13025	COG3604	Transcriptional regulator
GPX85_RS13030	COG1151	hydroxylamine reductase activity
GPX85_RS13035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPX85_RS13040	COG1252	NADH dehydrogenase
GPX85_RS13045	COG1454	alcohol dehydrogenase
GPX85_RS13045	COG1012	belongs to the aldehyde dehydrogenase family
GPX85_RS13050	COG2095	MarC family integral membrane protein
GPX85_RS13055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPX85_RS13060	COG1757	Na H antiporter
GPX85_RS13065	COG3081	Nucleoid-associated protein
GPX85_RS13075	COG3083	sulfuric ester hydrolase activity
GPX85_RS13195	COG0740	serine-type endopeptidase activity
GPX85_RS13205	COG1802	Transcriptional regulator
GPX85_RS13205	COG4626	Terminase
GPX85_RS13240	COG3772	lysozyme
GPX85_RS13270	COG1403	HNH endonuclease
GPX85_RS13360	COG5532	Uncharacterized conserved protein (DUF2303)
GPX85_RS13455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPX85_RS13460	COG2194	sulfuric ester hydrolase activity
GPX85_RS13465	COG2239	Acts as a magnesium transporter
GPX85_RS13475	COG1942	4-Oxalocrotonate Tautomerase
GPX85_RS13485	COG0697	spore germination
GPX85_RS13490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPX85_RS13495	COG1846	Transcriptional regulator
GPX85_RS13500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPX85_RS13505	COG2313	pseudouridylate synthase activity
GPX85_RS13605	COG5001	Diguanylate cyclase
GPX85_RS13610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPX85_RS13625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPX85_RS13630	COG2832	Protein of unknown function (DUF454)
GPX85_RS13635	COG0745	RESPONSE REGULATOR receiver
GPX85_RS13640	COG0583	DNA-binding transcription factor activity
GPX85_RS13645	COG1024	Enoyl-CoA hydratase
GPX85_RS13645	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPX85_RS13650	COG0183	Belongs to the thiolase family
GPX85_RS13655	COG2067	long-chain fatty acid transport protein
GPX85_RS13660	COG2067	long-chain fatty acid transport protein
GPX85_RS13665	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPX85_RS13670	COG2982	Protein involved in outer membrane biogenesis
GPX85_RS13675	COG0572	uridine kinase
GPX85_RS13680	COG0489	protein tyrosine kinase activity
GPX85_RS13685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPX85_RS13685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPX85_RS13705	COG0517	IMP dehydrogenase activity
GPX85_RS13705	COG0516	GMP reductase activity
GPX85_RS13710	COG0314	molybdopterin synthase activity
GPX85_RS13715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPX85_RS13725	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPX85_RS13730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPX85_RS13735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPX85_RS13740	COG2951	lytic endotransglycosylase activity
GPX85_RS13745	COG3100	YcgL domain-containing protein
GPX85_RS13750	COG0850	regulation of cytokinetic process
GPX85_RS13755	COG2894	cell division
GPX85_RS13765	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPX85_RS13770	COG0318	PFAM AMP-dependent synthetase and ligase
GPX85_RS13775	COG1073	alpha beta
GPX85_RS13775	COG2226	methyltransferase
GPX85_RS13790	COG1214	PFAM Peptidase M22, glycoprotease
GPX85_RS13795	COG1199	ATP-dependent helicase activity
GPX85_RS13805	COG0788	formyltetrahydrofolate deformylase activity
GPX85_RS13810	COG1902	pentaerythritol trinitrate reductase activity
GPX85_RS13810	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPX85_RS13815	COG0616	signal peptide processing
GPX85_RS13820	COG0252	asparaginase activity
GPX85_RS13825	COG3139	Protein of unknown function (DUF1315)
GPX85_RS13835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPX85_RS13840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPX85_RS13850	COG2226	methyltransferase
GPX85_RS13865	COG3122	Protein conserved in bacteria
GPX85_RS13870	COG0745	RESPONSE REGULATOR receiver
GPX85_RS13875	COG2205	protein histidine kinase activity
GPX85_RS13880	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPX85_RS13880	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPX85_RS13880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPX85_RS13880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPX85_RS13900	COG1403	HNH endonuclease
GPX85_RS13905	COG1309	transcriptional regulator
GPX85_RS13910	COG2130	NADP-dependent
GPX85_RS13920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPX85_RS13925	COG0488	(ABC) transporter
GPX85_RS13935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPX85_RS13935	COG3453	Protein conserved in bacteria
GPX85_RS13955	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GPX85_RS13960	COG3639	organic phosphonate transmembrane transporter activity
GPX85_RS13965	COG3639	organic phosphonate transmembrane transporter activity
GPX85_RS13970	COG0840	transmembrane signaling receptor activity
GPX85_RS13975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPX85_RS13980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPX85_RS14000	COG2853	Lipoprotein
GPX85_RS14010	COG0835	chemotaxis
GPX85_RS14020	COG1192	Involved in chromosome partitioning
GPX85_RS14025	COG2201	protein-glutamate methylesterase activity
GPX85_RS14030	COG2198	Histidine kinase
GPX85_RS14030	COG0643	Histidine kinase
GPX85_RS14035	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPX85_RS14050	COG0455	bacterial-type flagellum organization
GPX85_RS14065	COG2062	phosphohistidine phosphatase, SixA
GPX85_RS14070	COG1025	Belongs to the peptidase M16 family
GPX85_RS14075	COG3102	Protein conserved in bacteria
GPX85_RS14095	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GPX85_RS14100	COG1918	ferrous iron import across plasma membrane
GPX85_RS14110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPX85_RS14115	COG1121	(ABC) transporter
GPX85_RS14120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPX85_RS14125	COG1757	Na H antiporter
GPX85_RS14145	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPX85_RS14150	COG0567	Dehydrogenase, E1 component
GPX85_RS14165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPX85_RS14170	COG2009	succinate dehydrogenase
GPX85_RS14180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPX85_RS14190	COG0033	Phosphoglucomutase
GPX85_RS14195	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPX85_RS14200	COG0596	Alpha beta hydrolase
GPX85_RS14210	COG1346	cytolysis
GPX85_RS14215	COG1380	Effector of murein hydrolase LrgA
GPX85_RS14220	COG0583	DNA-binding transcription factor activity
GPX85_RS14230	COG0735	belongs to the Fur family
GPX85_RS14235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPX85_RS14240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPX85_RS14245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPX85_RS14250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPX85_RS14250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPX85_RS14265	COG3101	peptidyl-lysine hydroxylation
GPX85_RS14270	COG2860	membrane
GPX85_RS14275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPX85_RS14280	COG2890	protein-(glutamine-N5) methyltransferase activity
GPX85_RS14285	COG2840	Smr protein MutS2
GPX85_RS14300	COG1987	bacterial-type flagellum assembly
GPX85_RS14350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPX85_RS14365	COG2204	response regulator
GPX85_RS14370	COG4191	Histidine kinase
GPX85_RS14375	COG2204	response regulator
GPX85_RS14380	COG1516	flagellar protein fliS
GPX85_RS14390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPX85_RS14395	COG1334	flagellar protein FlaG
GPX85_RS14400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX85_RS14405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX85_RS14430	COG1393	Belongs to the ArsC family
GPX85_RS14435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPX85_RS14440	COG1876	peptidase activity
GPX85_RS14450	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPX85_RS14455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPX85_RS14460	COG2716	regulation of RNA biosynthetic process
GPX85_RS14465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPX85_RS14485	COG4783	chaperone-mediated protein folding
GPX85_RS14490	COG1393	Belongs to the ArsC family
GPX85_RS14520	COG2912	Transglutaminase-like superfamily
GPX85_RS14525	COG3094	Invasion gene expression up-regulator, SirB
GPX85_RS14530	COG2890	protein-(glutamine-N5) methyltransferase activity
GPX85_RS14535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPX85_RS14540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPX85_RS14550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPX85_RS14555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPX85_RS14560	COG0193	aminoacyl-tRNA hydrolase activity
GPX85_RS14565	COG0012	GTP binding
GPX85_RS14645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX85_RS14650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPX85_RS14665	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPX85_RS14665	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPX85_RS14670	COG1706	bacterial-type flagellum-dependent cell motility
GPX85_RS14675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPX85_RS14680	COG4786	Flagellar basal body rod
GPX85_RS14685	COG4787	bacterial-type flagellum-dependent cell motility
GPX85_RS14690	COG1749	Flagellar hook protein flgE
GPX85_RS14695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPX85_RS14700	COG1558	bacterial-type flagellum-dependent cell motility
GPX85_RS14705	COG1815	bacterial-type flagellum-dependent cell motility
GPX85_RS14715	COG0784	Response regulator, receiver
GPX85_RS14715	COG0835	chemotaxis
GPX85_RS14725	COG2747	anti-sigma28 factor FlgM
GPX85_RS14765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPX85_RS14770	COG2217	Heavy metal translocating P-type atpase
GPX85_RS14770	COG2608	mercury ion transmembrane transporter activity
GPX85_RS14790	COG2840	Smr protein MutS2
GPX85_RS14795	COG1187	pseudouridine synthase activity
GPX85_RS14800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPX85_RS14805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPX85_RS14810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPX85_RS14815	COG0121	glutamine amidotransferase
GPX85_RS14820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPX85_RS14825	COG1960	acyl-CoA dehydrogenase activity
GPX85_RS14835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPX85_RS14840	COG0328	RNA-DNA hybrid ribonuclease activity
GPX85_RS14845	COG2226	methyltransferase
GPX85_RS14850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPX85_RS14855	COG1388	LysM domain
GPX85_RS14855	COG0741	lytic transglycosylase activity
GPX85_RS14880	COG0347	Belongs to the P(II) protein family
GPX85_RS14885	COG0037	tRNA processing
GPX85_RS14895	COG0587	DNA-directed DNA polymerase activity
GPX85_RS14900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPX85_RS14905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX85_RS14910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX85_RS14915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPX85_RS14920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPX85_RS14925	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPX85_RS14935	COG0750	zinc metalloprotease
GPX85_RS14940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPX85_RS14945	COG0575	Belongs to the CDS family
GPX85_RS14950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPX85_RS14955	COG0233	cytoplasmic translational termination
GPX85_RS14965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPX85_RS14975	COG0024	Methionine aminopeptidase
GPX85_RS14980	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPX85_RS14990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPX85_RS15000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPX85_RS15020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPX85_RS15020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPX85_RS15025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPX85_RS15030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPX85_RS15035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPX85_RS15050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPX85_RS15055	COG2252	PERMEase
GPX85_RS15060	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPX85_RS15065	COG0189	ligase activity
GPX85_RS15065	COG4067	protein conserved in archaea
GPX85_RS15070	COG0189	ligase activity
GPX85_RS15080	COG0733	neurotransmitter:sodium symporter activity
GPX85_RS15090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPX85_RS15100	COG1477	protein flavinylation
GPX85_RS15110	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPX85_RS15115	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPX85_RS15120	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPX85_RS15125	COG1805	sodium ion transport
GPX85_RS15130	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPX85_RS15135	COG0271	Belongs to the BolA IbaG family
GPX85_RS15215	COG0542	response to heat
GPX85_RS15225	COG0564	pseudouridine synthase activity
GPX85_RS15230	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPX85_RS15235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPX85_RS15240	COG0077	Prephenate dehydratase
GPX85_RS15240	COG1605	Chorismate mutase
GPX85_RS15245	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPX85_RS15270	COG0287	Prephenate dehydrogenase
GPX85_RS15270	COG1605	Chorismate mutase
GPX85_RS15275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPX85_RS15280	COG3275	phosphorelay sensor kinase activity
GPX85_RS15285	COG3279	Response regulator of the LytR AlgR family
GPX85_RS15295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPX85_RS15305	COG1966	Carbon starvation protein
GPX85_RS15310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPX85_RS15315	COG1047	Peptidyl-prolyl cis-trans
GPX85_RS15320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPX85_RS15325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPX85_RS15330	COG0196	riboflavin kinase activity
GPX85_RS15335	COG0728	peptidoglycan biosynthetic process
GPX85_RS15345	COG0640	Transcriptional regulator
GPX85_RS15350	COG0583	DNA-binding transcription factor activity
GPX85_RS15355	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPX85_RS15360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPX85_RS15370	COG0730	response to heat
GPX85_RS15380	COG0494	nUDIX hydrolase
GPX85_RS15385	COG3066	DNA modification
GPX85_RS15390	COG0667	Aldo Keto reductase
GPX85_RS15400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPX85_RS15415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPX85_RS15420	COG0513	Belongs to the DEAD box helicase family
GPX85_RS15425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPX85_RS15445	COG3153	acetyltransferase
GPX85_RS15475	COG1185	polyribonucleotide nucleotidyltransferase activity
GPX85_RS15480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPX85_RS15490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPX85_RS15495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPX85_RS15500	COG0195	Participates in both transcription termination and antitermination
GPX85_RS15520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPX85_RS15525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPX85_RS15530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPX85_RS15535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPX85_RS15545	COG1534	Rna-binding protein
GPX85_RS15550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPX85_RS15555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPX85_RS15560	COG2027	D-alanyl-D-alanine carboxypeptidase
GPX85_RS15565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPX85_RS15570	COG0739	heme binding
GPX85_RS15575	COG0316	Belongs to the HesB IscA family
GPX85_RS15580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPX85_RS15585	COG0628	permease
GPX85_RS15595	COG0784	Response regulator, receiver
GPX85_RS15595	COG2198	Histidine kinase
GPX85_RS15595	COG2205	protein histidine kinase activity
GPX85_RS15595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPX85_RS15600	COG0747	negative chemotaxis
GPX85_RS15615	COG0444	Belongs to the ABC transporter superfamily
GPX85_RS15620	COG4608	Belongs to the ABC transporter superfamily
GPX85_RS15640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPX85_RS15645	COG1840	ABC-type Fe3 transport system, periplasmic component
GPX85_RS15655	COG3842	ATPase activity
GPX85_RS15660	COG0004	ammonium transporteR
GPX85_RS15665	COG0347	Belongs to the P(II) protein family
GPX85_RS15675	COG1929	Belongs to the glycerate kinase type-1 family
GPX85_RS15680	COG4771	TonB-dependent receptor
GPX85_RS15690	COG0745	RESPONSE REGULATOR receiver
GPX85_RS15700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPX85_RS15705	COG1121	(ABC) transporter
GPX85_RS15740	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPX85_RS15745	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPX85_RS15755	COG1643	Atp-dependent helicase
GPX85_RS15765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPX85_RS15770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPX85_RS15780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPX85_RS15785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPX85_RS15790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPX85_RS15795	COG0842	Transport permease protein
GPX85_RS15800	COG1131	(ABC) transporter
GPX85_RS15805	COG0288	reversible hydration of carbon dioxide
GPX85_RS15825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPX85_RS15830	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPX85_RS15835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPX85_RS15840	COG2186	Transcriptional regulator
GPX85_RS15845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPX85_RS15850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPX85_RS15860	COG0716	FMN binding
GPX85_RS15870	COG0157	Belongs to the NadC ModD family
GPX85_RS15880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPX85_RS15885	COG1459	type II secretion system
GPX85_RS15900	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPX85_RS15905	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPX85_RS15915	COG0187	DNA topoisomerase II activity
GPX85_RS15920	COG3150	esterase
GPX85_RS15930	COG3151	Protein conserved in bacteria
GPX85_RS15940	COG1538	Outer membrane efflux protein
GPX85_RS15950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPX85_RS15960	COG3025	triphosphatase activity
GPX85_RS15965	COG1392	Phosphate transport regulator
GPX85_RS15970	COG0306	phosphate transporter
GPX85_RS15975	COG4991	sh3 domain protein
GPX85_RS15980	COG0617	tRNA 3'-terminal CCA addition
GPX85_RS15990	COG0504	CTP synthase activity
GPX85_RS15995	COG3956	TIGRFAM MazG family protein
GPX85_RS16000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPX85_RS16005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPX85_RS16020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPX85_RS16025	COG1381	Involved in DNA repair and RecF pathway recombination
GPX85_RS16040	COG0681	Belongs to the peptidase S26 family
GPX85_RS16045	COG0481	GTPase activity
GPX85_RS16050	COG3086	response to oxidative stress
GPX85_RS16055	COG3026	antisigma factor binding
GPX85_RS16065	COG1595	DNA-templated transcription, initiation
GPX85_RS16070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPX85_RS16085	COG0354	folic acid binding
GPX85_RS16100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPX85_RS16105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPX85_RS16115	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPX85_RS16125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPX85_RS16130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPX85_RS16135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPX85_RS16145	COG0028	Belongs to the TPP enzyme family
GPX85_RS16150	COG1022	Amp-dependent synthetase and ligase
GPX85_RS16155	COG0583	DNA-binding transcription factor activity
GPX85_RS16165	COG0671	phosphoesterase, PA-phosphatase related
GPX85_RS16170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPX85_RS16175	COG0473	3-isopropylmalate dehydrogenase activity
GPX85_RS16180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPX85_RS16185	COG0066	3-isopropylmalate dehydratase activity
GPX85_RS16280	COG4974	Belongs to the 'phage' integrase family
GPX85_RS16300	COG2314	TM2 domain
GPX85_RS16305	COG2378	regulation of single-species biofilm formation
GPX85_RS16355	COG0270	DNA (cytosine-5-)-methyltransferase activity
GPX85_RS16375	COG0795	lipopolysaccharide-transporting ATPase activity
GPX85_RS16380	COG0795	lipopolysaccharide-transporting ATPase activity
GPX85_RS16385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPX85_RS16390	COG2927	DNA polymerase III (CHI subunit)
GPX85_RS16395	COG0525	valine-tRNA ligase activity
GPX85_RS16415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPX85_RS16420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPX85_RS16425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPX85_RS16430	COG0540	Belongs to the ATCase OTCase family
GPX85_RS16435	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPX85_RS16440	COG0251	oxidation-reduction process
GPX85_RS16445	COG0204	Acyl-transferase
GPX85_RS16450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPX85_RS16455	COG5007	Belongs to the BolA IbaG family
GPX85_RS16465	COG2854	intermembrane phospholipid transfer
GPX85_RS16470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPX85_RS16475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPX85_RS16480	COG1127	ABC transporter
GPX85_RS16490	COG0517	IMP dehydrogenase activity
GPX85_RS16490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPX85_RS16495	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GPX85_RS16505	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPX85_RS16510	COG1137	ATPase activity
GPX85_RS16520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPX85_RS16525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX85_RS16535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPX85_RS16545	COG0312	modulator of DNA gyrase
GPX85_RS16550	COG3028	Belongs to the UPF0307 family
GPX85_RS16555	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPX85_RS16565	COG4143	(ABC) transporter
GPX85_RS16570	COG0163	prenyltransferase activity
GPX85_RS16575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPX85_RS16580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPX85_RS16585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPX85_RS16590	COG2105	PFAM AIG2 family protein
GPX85_RS16600	COG0729	surface antigen
GPX85_RS16615	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPX85_RS16630	COG1136	(ABC) transporter
GPX85_RS16630	COG0577	efflux transmembrane transporter activity
GPX85_RS16650	COG0529	Catalyzes the synthesis of activated sulfate
GPX85_RS16655	COG2895	sulfate adenylyltransferase (ATP) activity
GPX85_RS16660	COG0175	sulfate reduction
GPX85_RS16665	COG1648	precorrin-2 dehydrogenase activity
GPX85_RS16665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPX85_RS16680	COG0513	Belongs to the DEAD box helicase family
GPX85_RS16685	COG2153	protein acetylation
GPX85_RS16695	COG0545	Peptidyl-prolyl cis-trans isomerase
GPX85_RS16705	COG0203	ribosomal protein L17
GPX85_RS16710	COG0202	RNA polymerase activity
GPX85_RS16715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPX85_RS16720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPX85_RS16735	COG0201	protein transport
GPX85_RS16745	COG1841	ribosomal large subunit assembly
GPX85_RS16760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPX85_RS16765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPX85_RS16770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPX85_RS16775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPX85_RS16785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPX85_RS16795	COG0255	Belongs to the universal ribosomal protein uL29 family
GPX85_RS16805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPX85_RS16810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPX85_RS16815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPX85_RS16825	COG0089	rRNA binding
GPX85_RS16830	COG0088	Forms part of the polypeptide exit tunnel
GPX85_RS16835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPX85_RS16840	COG0051	transcription antitermination factor activity, RNA binding
GPX85_RS16845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPX85_RS16850	COG0557	exoribonuclease II activity
GPX85_RS16855	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPX85_RS16860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPX85_RS16865	COG1446	asparaginase
GPX85_RS16870	COG1047	Peptidyl-prolyl cis-trans
GPX85_RS16885	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPX85_RS16890	COG0488	(ABC) transporter
GPX85_RS16900	COG0429	hydrolase of the alpha beta-hydrolase fold
GPX85_RS16910	COG3954	Phosphoribulokinase
GPX85_RS16915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPX85_RS16935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPX85_RS16940	COG0512	Glutamine amidotransferase of anthranilate synthase
GPX85_RS16950	COG0180	Tryptophanyl-tRNA synthetase
GPX85_RS16955	COG0546	phosphoglycolate phosphatase activity
GPX85_RS16960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPX85_RS16965	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPX85_RS16980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPX85_RS17010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPX85_RS17025	COG0165	Argininosuccinate lyase
GPX85_RS17025	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPX85_RS17035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPX85_RS17040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPX85_RS17045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPX85_RS17050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPX85_RS17060	COG1045	serine acetyltransferase
GPX85_RS17065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPX85_RS17070	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPX85_RS17075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPX85_RS17080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPX85_RS17085	COG1053	succinate dehydrogenase
GPX85_RS17090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPX85_RS17095	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPX85_RS17100	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPX85_RS17105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPX85_RS17110	COG1509	lysine 2,3-aminomutase activity
GPX85_RS17115	COG1285	pathogenesis
GPX85_RS17120	COG0459	protein refolding
GPX85_RS17125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPX85_RS17160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPX85_RS17165	COG1575	Belongs to the MenA family. Type 1 subfamily
GPX85_RS17170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPX85_RS17175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPX85_RS17185	COG1609	Transcriptional regulator
GPX85_RS17190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPX85_RS17200	COG0281	malic enzyme
GPX85_RS17210	COG0626	cystathionine gamma-synthase activity
GPX85_RS17215	COG0527	aspartate kinase activity
GPX85_RS17215	COG0460	homoserine dehydrogenase
GPX85_RS17220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPX85_RS17230	COG1494	fructose-1,6-bisphosphatase
GPX85_RS17235	COG0205	6-phosphofructokinase activity
GPX85_RS17240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPX85_RS17250	COG0745	RESPONSE REGULATOR receiver
GPX85_RS17255	COG2205	protein histidine kinase activity
GPX85_RS17260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPX85_RS17265	COG1278	Cold shock
GPX85_RS17270	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPX85_RS17275	COG1027	Aspartate ammonia-lyase
GPX85_RS17280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPX85_RS17285	COG1288	antiporter activity