locus-tag	class	description
EPB53_RS00005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPB53_RS00015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPB53_RS00020	COG2199	diguanylate cyclase activity
EPB53_RS00045	COG5433	transposase activity
EPB53_RS00150	COG2313	pseudouridylate synthase activity
EPB53_RS00155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPB53_RS00160	COG1846	Transcriptional regulator
EPB53_RS00165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPB53_RS00170	COG0697	spore germination
EPB53_RS00180	COG1942	4-Oxalocrotonate Tautomerase
EPB53_RS00190	COG2239	Acts as a magnesium transporter
EPB53_RS00195	COG2194	sulfuric ester hydrolase activity
EPB53_RS00200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB53_RS00210	COG3083	sulfuric ester hydrolase activity
EPB53_RS00215	COG3082	Protein of unknown function (DUF1414)
EPB53_RS00220	COG3081	Nucleoid-associated protein
EPB53_RS00225	COG1757	Na H antiporter
EPB53_RS00235	COG2095	MarC family integral membrane protein
EPB53_RS00240	COG1012	belongs to the aldehyde dehydrogenase family
EPB53_RS00240	COG1454	alcohol dehydrogenase
EPB53_RS00245	COG1252	NADH dehydrogenase
EPB53_RS00250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB53_RS00255	COG1151	hydroxylamine reductase activity
EPB53_RS00260	COG3604	Transcriptional regulator
EPB53_RS00275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPB53_RS00285	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB53_RS00290	COG1136	(ABC) transporter
EPB53_RS00365	COG4387	Mu-like prophage protein GP36
EPB53_RS00385	COG4397	Mu-like prophage major head subunit gpT
EPB53_RS00395	COG4388	Caudovirus prohead serine protease
EPB53_RS00400	COG5005	Phage virion morphogenesis
EPB53_RS00410	COG4383	Mu-like prophage protein gp29
EPB53_RS00415	COG4373	Mu-like prophage FluMu protein gp28
EPB53_RS00425	COG0640	Transcriptional regulator
EPB53_RS00545	COG2842	Transposition protein
EPB53_RS00550	COG2801	Transposase and inactivated derivatives
EPB53_RS00555	COG3423	Transcriptional regulator
EPB53_RS00570	COG0658	competence protein
EPB53_RS00570	COG2333	competence protein COMEC
EPB53_RS00575	COG1132	(ABC) transporter
EPB53_RS00580	COG1663	tetraacyldisaccharide 4'-kinase activity
EPB53_RS00590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPB53_RS00595	COG2719	SpoVR family
EPB53_RS00600	COG2718	Belongs to the UPF0229 family
EPB53_RS00605	COG2766	serine protein kinase
EPB53_RS00615	COG3013	Belongs to the UPF0304 family
EPB53_RS00620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB53_RS00630	COG1882	Formate acetyltransferase
EPB53_RS00655	COG4160	amino acid transport
EPB53_RS00660	COG0708	Exodeoxyribonuclease III
EPB53_RS00685	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB53_RS00690	COG3012	SEC-C Motif Domain Protein
EPB53_RS00695	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB53_RS00700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB53_RS00705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB53_RS00710	COG0215	cysteine-tRNA ligase activity
EPB53_RS00720	COG0632	four-way junction helicase activity
EPB53_RS00730	COG1271	oxidase subunit
EPB53_RS00735	COG1294	oxidase, subunit
EPB53_RS00740	COG4890	Cyd operon protein YbgT
EPB53_RS00750	COG0824	Thioesterase
EPB53_RS00755	COG0811	peptide transport
EPB53_RS00770	COG0823	Involved in the tonB-independent uptake of proteins
EPB53_RS00775	COG2885	chlorophyll binding
EPB53_RS00780	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EPB53_RS00785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPB53_RS00860	COG3328	transposase activity
EPB53_RS00865	COG5433	transposase activity
EPB53_RS00870	COG0840	transmembrane signaling receptor activity
EPB53_RS00880	COG0814	amino acid
EPB53_RS00930	COG3033	Beta-eliminating lyase
EPB53_RS00935	COG2311	Membrane
EPB53_RS00945	COG3036	rescue of stalled ribosome
EPB53_RS00965	COG1704	LemA family
EPB53_RS00970	COG0719	Fe-S assembly protein
EPB53_RS00975	COG0396	ATPase activity
EPB53_RS00980	COG0719	Fe-S assembly protein
EPB53_RS00985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPB53_RS01000	COG2166	iron-sulfur cluster assembly
EPB53_RS01010	COG2188	Transcriptional regulator
EPB53_RS01015	COG1131	(ABC) transporter
EPB53_RS01025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB53_RS01035	COG0659	secondary active sulfate transmembrane transporter activity
EPB53_RS01040	COG0640	Transcriptional regulator
EPB53_RS01045	COG0798	PFAM Bile acid sodium symporter
EPB53_RS01070	COG0798	PFAM Bile acid sodium symporter
EPB53_RS01080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB53_RS01085	COG0581	inorganic phosphate transmembrane transporter activity
EPB53_RS01090	COG0573	inorganic phosphate transmembrane transporter activity
EPB53_RS01100	COG0640	Transcriptional regulator
EPB53_RS01105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB53_RS01135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB53_RS01140	COG2985	domain, Protein
EPB53_RS01140	COG3273	potassium ion transport
EPB53_RS01145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB53_RS01150	COG1454	alcohol dehydrogenase
EPB53_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
EPB53_RS01155	COG1737	Transcriptional regulator
EPB53_RS01160	COG0076	glutamate decarboxylase activity
EPB53_RS01165	COG2431	L-lysine efflux transmembrane transporter activity
EPB53_RS01175	COG3070	regulator of competence-specific genes
EPB53_RS01190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB53_RS01190	COG4191	Histidine kinase
EPB53_RS01190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB53_RS01190	COG4191	Histidine kinase
EPB53_RS01200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EPB53_RS01210	COG1032	radical SAM domain protein
EPB53_RS01220	COG0612	Peptidase, M16
EPB53_RS01235	COG0583	DNA-binding transcription factor activity
EPB53_RS01240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPB53_RS01245	COG0501	Belongs to the peptidase M48B family
EPB53_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
EPB53_RS01285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPB53_RS01290	COG2915	High frequency lysogenization protein hflD homolog
EPB53_RS01295	COG0482	sulfurtransferase activity
EPB53_RS01300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB53_RS01305	COG2916	Histone family protein nucleoid-structuring protein H-NS
EPB53_RS01310	COG1757	Na H antiporter
EPB53_RS01315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPB53_RS01320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPB53_RS01330	COG0131	Imidazoleglycerol-phosphate dehydratase
EPB53_RS01330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB53_RS01335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPB53_RS01345	COG0107	imidazoleglycerol-phosphate synthase activity
EPB53_RS01350	COG0140	phosphoribosyl-ATP diphosphatase activity
EPB53_RS01350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPB53_RS01365	COG1278	Cold shock
EPB53_RS01370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPB53_RS01375	COG0542	response to heat
EPB53_RS01380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPB53_RS01390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPB53_RS01395	COG3134	Outer membrane lipoprotein
EPB53_RS01410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB53_RS01415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB53_RS01420	COG0297	glycogen (starch) synthase activity
EPB53_RS01430	COG3070	regulator of competence-specific genes
EPB53_RS01435	COG1609	Transcriptional regulator
EPB53_RS01440	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB53_RS01445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB53_RS01455	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EPB53_RS01465	COG0189	ligase activity
EPB53_RS01475	COG0189	ligase activity
EPB53_RS01475	COG4067	protein conserved in archaea
EPB53_RS01480	COG0500	methyltransferase
EPB53_RS01485	COG4106	trans-aconitate 2-methyltransferase activity
EPB53_RS01490	COG1801	Protein of unknown function DUF72
EPB53_RS01500	COG1435	thymidine kinase activity
EPB53_RS01505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB53_RS01520	COG2116	formate transmembrane transporter activity
EPB53_RS01530	COG4172	Belongs to the ABC transporter superfamily
EPB53_RS01545	COG4168	peptide transport system, permease
EPB53_RS01555	COG0519	Catalyzes the synthesis of GMP from XMP
EPB53_RS01570	COG0733	neurotransmitter:sodium symporter activity
EPB53_RS01575	COG0564	pseudouridine synthase activity
EPB53_RS01580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPB53_RS01585	COG4136	ATPase activity
EPB53_RS01595	COG4134	Bacterial extracellular solute-binding protein
EPB53_RS01605	COG3313	Fe-S protein
EPB53_RS01615	COG0814	amino acid
EPB53_RS01625	COG1823	symporter activity
EPB53_RS01635	COG2988	succinylglutamate desuccinylase activity
EPB53_RS01640	COG4139	cobalamin transport
EPB53_RS01655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB53_RS01660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB53_RS01685	COG0583	DNA-binding transcription factor activity
EPB53_RS01695	COG1451	nucleotide metabolic process
EPB53_RS01710	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EPB53_RS01725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB53_RS01740	COG0784	Response regulator, receiver
EPB53_RS01740	COG0835	chemotaxis
EPB53_RS01785	COG0444	Belongs to the ABC transporter superfamily
EPB53_RS01805	COG0747	negative chemotaxis
EPB53_RS01825	COG4608	Belongs to the ABC transporter superfamily
EPB53_RS01835	COG1609	Transcriptional regulator
EPB53_RS01845	COG4580	involved in the transport of maltose and maltodextrins
EPB53_RS01850	COG1472	Belongs to the glycosyl hydrolase 3 family
EPB53_RS01860	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB53_RS01870	COG3290	protein histidine kinase activity
EPB53_RS01875	COG1518	maintenance of DNA repeat elements
EPB53_RS01915	COG2205	protein histidine kinase activity
EPB53_RS01920	COG0745	RESPONSE REGULATOR receiver
EPB53_RS02015	COG0415	Belongs to the DNA photolyase family
EPB53_RS02020	COG1271	oxidase subunit
EPB53_RS02025	COG1294	oxidase, subunit
EPB53_RS02030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB53_RS02035	COG1254	Belongs to the acylphosphatase family
EPB53_RS02040	COG2920	part of a sulfur-relay system
EPB53_RS02045	COG0670	Belongs to the BI1 family
EPB53_RS02050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB53_RS02060	COG0561	phosphatase activity
EPB53_RS02065	COG0602	queuosine metabolic process
EPB53_RS02070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPB53_RS02085	COG1132	(ABC) transporter
EPB53_RS02090	COG1132	(ABC) transporter
EPB53_RS02105	COG5002	protein histidine kinase activity
EPB53_RS02110	COG0443	Heat shock 70 kDa protein
EPB53_RS02115	COG0443	Heat shock 70 kDa protein
EPB53_RS02130	COG0840	transmembrane signaling receptor activity
EPB53_RS02145	COG1643	Atp-dependent helicase
EPB53_RS02155	COG0583	DNA-binding transcription factor activity
EPB53_RS02160	COG2814	Major facilitator Superfamily
EPB53_RS02170	COG2200	EAL domain
EPB53_RS02180	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EPB53_RS02190	COG0625	glutathione transferase activity
EPB53_RS02195	COG3842	ATPase activity
EPB53_RS02200	COG0395	ABC-type sugar transport system, permease component
EPB53_RS02205	COG1175	transmembrane transport
EPB53_RS02235	COG2198	Histidine kinase
EPB53_RS02235	COG0643	Histidine kinase
EPB53_RS02245	COG0835	chemotaxis
EPB53_RS02255	COG2201	protein-glutamate methylesterase activity
EPB53_RS02265	COG0811	peptide transport
EPB53_RS02270	COG0811	peptide transport
EPB53_RS02275	COG0848	biopolymer transport protein
EPB53_RS02300	COG0534	Mate efflux family protein
EPB53_RS02305	COG0307	riboflavin synthase, alpha
EPB53_RS02315	COG0784	Response regulator, receiver
EPB53_RS02315	COG3437	response regulator, receiver
EPB53_RS02330	COG0393	Putative heavy-metal-binding
EPB53_RS02335	COG3001	Fructosamine kinase
EPB53_RS02345	COG0791	NLP P60 protein
EPB53_RS02355	COG3148	PFAM DTW domain containing protein
EPB53_RS02360	COG1940	carbohydrate kinase activity
EPB53_RS02370	COG0303	'Molybdopterin
EPB53_RS02375	COG0746	molybdenum cofactor guanylyltransferase activity
EPB53_RS02385	COG4662	Binding-protein-dependent transport system inner membrane component
EPB53_RS02400	COG4191	Histidine kinase
EPB53_RS02405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPB53_RS02435	COG3383	formate dehydrogenase (NAD+) activity
EPB53_RS02435	COG0243	molybdopterin cofactor binding
EPB53_RS02440	COG0437	4 iron, 4 sulfur cluster binding
EPB53_RS02455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPB53_RS02470	COG1177	transmembrane transport
EPB53_RS02480	COG3842	ATPase activity
EPB53_RS02505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB53_RS02520	COG0784	Response regulator, receiver
EPB53_RS02520	COG2205	protein histidine kinase activity
EPB53_RS02530	COG3120	sequence-specific DNA binding
EPB53_RS02535	COG1067	ATP-dependent peptidase activity
EPB53_RS02540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB53_RS02555	COG0488	(ABC) transporter
EPB53_RS02560	COG0116	Belongs to the methyltransferase superfamily
EPB53_RS02560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB53_RS02570	COG0167	dihydroorotate dehydrogenase activity
EPB53_RS02600	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EPB53_RS02605	COG1956	GAF domain-containing protein
EPB53_RS02610	COG1132	(ABC) transporter
EPB53_RS02615	COG2995	paraquat-inducible protein a
EPB53_RS02620	COG3008	intermembrane lipid transfer
EPB53_RS02630	COG2996	Protein conserved in bacteria
EPB53_RS02650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB53_RS02655	COG1666	GTP binding
EPB53_RS02665	COG1115	amino acid carrier protein
EPB53_RS02670	COG1280	lysine exporter protein (LysE YggA)
EPB53_RS02675	COG0003	Pfam Anion-transporting ATPase
EPB53_RS02685	COG1966	Carbon starvation protein
EPB53_RS02690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPB53_RS02725	COG3706	GGDEF domain
EPB53_RS02740	COG3158	transport of potassium into the cell
EPB53_RS02755	COG0372	Belongs to the citrate synthase family
EPB53_RS02760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EPB53_RS02785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB53_RS02785	COG4191	Histidine kinase
EPB53_RS02790	COG0471	metal ion transport
EPB53_RS02800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB53_RS02805	COG5006	permease, DMT superfamily
EPB53_RS02815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB53_RS02825	COG3768	UPF0283 membrane protein
EPB53_RS02830	COG3106	COG3106 Predicted ATPase
EPB53_RS02845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB53_RS02850	COG0494	nUDIX hydrolase
EPB53_RS02855	COG0814	amino acid
EPB53_RS02865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB53_RS02880	COG0720	synthase
EPB53_RS02885	COG0017	Asparaginyl-tRNA synthetase
EPB53_RS02890	COG1448	Aminotransferase
EPB53_RS02905	COG2176	DNA-directed DNA polymerase activity
EPB53_RS02910	COG0840	transmembrane signaling receptor activity
EPB53_RS02915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB53_RS02920	COG1846	Transcriptional regulator
EPB53_RS02935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB53_RS02945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB53_RS02965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB53_RS03005	COG1748	Saccharopine dehydrogenase
EPB53_RS03015	COG1320	monovalent cation:proton antiporter activity
EPB53_RS03020	COG2212	antiporter activity
EPB53_RS03025	COG1863	multisubunit Na H antiporter MnhE subunit
EPB53_RS03030	COG0651	ATP synthesis coupled electron transport
EPB53_RS03035	COG1006	Multisubunit Na H antiporter MnhC subunit
EPB53_RS03040	COG2111	Na H antiporter
EPB53_RS03045	COG2111	Na H antiporter
EPB53_RS03045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPB53_RS03050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB53_RS03065	COG4181	ATPase activity
EPB53_RS03070	COG0534	Mate efflux family protein
EPB53_RS03075	COG0702	epimerase
EPB53_RS03080	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPB53_RS03085	COG5380	lipid catabolic process
EPB53_RS03095	COG2814	Major facilitator Superfamily
EPB53_RS03100	COG1187	pseudouridine synthase activity
EPB53_RS03105	COG1061	Type III restriction enzyme res subunit
EPB53_RS03110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPB53_RS03125	COG0583	DNA-binding transcription factor activity
EPB53_RS03130	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB53_RS03135	COG3842	ATPase activity
EPB53_RS03150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EPB53_RS03155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB53_RS03165	COG0583	DNA-binding transcription factor activity
EPB53_RS03195	COG3527	Alpha-acetolactate decarboxylase
EPB53_RS03210	COG2925	Exonuclease
EPB53_RS03215	COG1380	Effector of murein hydrolase LrgA
EPB53_RS03220	COG1346	cytolysis
EPB53_RS03235	COG3328	transposase activity
EPB53_RS03270	COG0776	regulation of translation
EPB53_RS03275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB53_RS03275	COG0072	phenylalanine-tRNA ligase activity
EPB53_RS03280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPB53_RS03325	COG2197	response regulator
EPB53_RS03340	COG0417	DNA replication proofreading
EPB53_RS03350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPB53_RS03355	COG3099	Belongs to the UPF0263 family
EPB53_RS03360	COG3097	Belongs to the UPF0267 family
EPB53_RS03385	COG2986	histidine ammonia-lyase
EPB53_RS03420	COG0277	FAD linked oxidase domain protein
EPB53_RS03420	COG0247	lactate metabolic process
EPB53_RS03435	COG2885	chlorophyll binding
EPB53_RS03455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPB53_RS03465	COG0281	malic enzyme
EPB53_RS03475	COG2949	membrane
EPB53_RS03485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPB53_RS03505	COG0492	ferredoxin-NADP+ reductase activity
EPB53_RS03510	COG4988	ABC transporter
EPB53_RS03515	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPB53_RS03530	COG0009	L-threonylcarbamoyladenylate synthase
EPB53_RS03535	COG0613	PHP domain protein
EPB53_RS03545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB53_RS03550	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB53_RS03555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPB53_RS03560	COG0134	indole-3-glycerol-phosphate synthase activity
EPB53_RS03560	COG0135	phosphoribosylanthranilate isomerase activity
EPB53_RS03565	COG0133	tryptophan synthase activity
EPB53_RS03575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB53_RS03590	COG2350	Protein conserved in bacteria
EPB53_RS03600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EPB53_RS03605	COG2226	methyltransferase
EPB53_RS03625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPB53_RS03630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPB53_RS03635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EPB53_RS03640	COG0653	protein targeting
EPB53_RS03650	COG3092	negative regulation of chromosome organization
EPB53_RS03655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB53_RS03660	COG0280	phosphate acetyltransferase
EPB53_RS03660	COG0857	belongs to the CobB CobQ family
EPB53_RS03665	COG0435	Glutathione S-transferase
EPB53_RS03680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB53_RS03685	COG0601	transmembrane transport
EPB53_RS03700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB53_RS03705	COG1621	beta-fructofuranosidase activity
EPB53_RS03715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB53_RS03715	COG1263	PTS System
EPB53_RS03725	COG2723	6-phospho-beta-galactosidase activity
EPB53_RS03730	COG1609	Transcriptional regulator
EPB53_RS03745	COG0366	Alpha amylase catalytic
EPB53_RS03750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB53_RS03780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPB53_RS03795	COG0840	transmembrane signaling receptor activity
EPB53_RS03800	COG1629	transport
EPB53_RS03810	COG1280	lysine exporter protein (LysE YggA)
EPB53_RS03820	COG0366	Alpha amylase catalytic
EPB53_RS03825	COG0488	(ABC) transporter
EPB53_RS03855	COG4607	ABC-type enterochelin transport system periplasmic component
EPB53_RS03860	COG1629	transport
EPB53_RS03860	COG4774	siderophore transport
EPB53_RS03870	COG0251	oxidation-reduction process
EPB53_RS03875	COG2706	6-phosphogluconolactonase activity
EPB53_RS03885	COG0800	Aldolase
EPB53_RS03895	COG4145	pantothenate transmembrane transporter activity
EPB53_RS03905	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EPB53_RS03925	COG1472	Belongs to the glycosyl hydrolase 3 family
EPB53_RS03930	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB53_RS03950	COG0697	spore germination
EPB53_RS03960	COG0318	PFAM AMP-dependent synthetase and ligase
EPB53_RS03965	COG0385	Bile acid
EPB53_RS04045	COG1522	sequence-specific DNA binding
EPB53_RS04055	COG3015	lipoprotein NlpE involved in copper resistance
EPB53_RS04100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EPB53_RS04105	COG1169	isochorismate synthase
EPB53_RS04110	COG0436	Aminotransferase
EPB53_RS04130	COG5433	transposase activity
EPB53_RS04135	COG0110	maltose O-acetyltransferase activity
EPB53_RS04165	COG1215	transferase activity, transferring glycosyl groups
EPB53_RS04180	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EPB53_RS04185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EPB53_RS04200	COG0616	signal peptide processing
EPB53_RS04205	COG1028	Short-chain dehydrogenase reductase Sdr
EPB53_RS04210	COG0784	Response regulator, receiver
EPB53_RS04210	COG0835	chemotaxis
EPB53_RS04215	COG1940	carbohydrate kinase activity
EPB53_RS04220	COG0469	pyruvate kinase activity
EPB53_RS04225	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB53_RS04240	COG0733	neurotransmitter:sodium symporter activity
EPB53_RS04255	COG5433	transposase activity
EPB53_RS04260	COG1263	PTS System
EPB53_RS04260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB53_RS04265	COG0084	hydrolase, TatD family'
EPB53_RS04275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPB53_RS04280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPB53_RS04285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPB53_RS04290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB53_RS04295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB53_RS04305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EPB53_RS04310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB53_RS04320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EPB53_RS04325	COG1399	metal-binding, possibly nucleic acid-binding protein
EPB53_RS04330	COG0424	maF-like protein
EPB53_RS04335	COG0564	pseudouridine synthase activity
EPB53_RS04340	COG1530	ribonuclease E activity
EPB53_RS04350	COG3150	esterase
EPB53_RS04375	COG0537	adenosine 5'-monophosphoramidase activity
EPB53_RS04380	COG0840	transmembrane signaling receptor activity
EPB53_RS04390	COG2186	Transcriptional regulator
EPB53_RS04395	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB53_RS04410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB53_RS04420	COG1845	cytochrome c oxidase, subunit III
EPB53_RS04425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EPB53_RS04430	COG0109	protoheme IX farnesyltransferase activity
EPB53_RS04480	COG0284	orotidine-5'-phosphate decarboxylase activity
EPB53_RS04485	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EPB53_RS04490	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EPB53_RS04495	COG0776	regulation of translation
EPB53_RS04500	COG0539	negative regulation of cytoplasmic translation
EPB53_RS04505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPB53_RS04515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB53_RS04520	COG0776	regulation of translation
EPB53_RS04525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPB53_RS04530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPB53_RS04540	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPB53_RS04545	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPB53_RS04550	COG1760	l-serine dehydratase
EPB53_RS04560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB53_RS04560	COG3153	acetyltransferase
EPB53_RS04575	COG2200	EAL domain
EPB53_RS04580	COG0840	transmembrane signaling receptor activity
EPB53_RS04590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPB53_RS04595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB53_RS04605	COG2198	Histidine kinase
EPB53_RS04610	COG2204	response regulator
EPB53_RS04615	COG0556	nucleotide-excision repair
EPB53_RS04625	COG1301	dicarboxylic acid transport
EPB53_RS04635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPB53_RS04640	COG4232	protein-disulfide reductase activity
EPB53_RS04650	COG4657	Part of a membrane complex involved in electron transport
EPB53_RS04655	COG2878	Part of a membrane complex involved in electron transport
EPB53_RS04660	COG4656	Part of a membrane complex involved in electron transport
EPB53_RS04665	COG4658	electron transport chain
EPB53_RS04670	COG4659	FMN binding
EPB53_RS04675	COG4660	Part of a membrane complex involved in electron transport
EPB53_RS04680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPB53_RS04685	COG0346	lactoylglutathione lyase activity
EPB53_RS04690	COG2885	chlorophyll binding
EPB53_RS04705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPB53_RS04710	COG1286	toxin biosynthetic process
EPB53_RS04715	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EPB53_RS04720	COG0285	dihydrofolate synthase activity
EPB53_RS04725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPB53_RS04730	COG0101	tRNA pseudouridine synthase activity
EPB53_RS04750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB53_RS04750	COG1263	PTS System
EPB53_RS04750	COG2190	(PTS) system
EPB53_RS04755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPB53_RS04760	COG1846	Transcriptional regulator
EPB53_RS04760	COG1940	carbohydrate kinase activity
EPB53_RS04765	COG0367	asparagine synthase
EPB53_RS04770	COG0250	Participates in transcription elongation, termination and antitermination
EPB53_RS04785	COG3328	transposase activity
EPB53_RS04795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPB53_RS04800	COG0563	adenylate kinase activity
EPB53_RS04805	COG0326	Molecular chaperone. Has ATPase activity
EPB53_RS04810	COG3710	Transcriptional regulator
EPB53_RS04825	COG0622	Phosphoesterase
EPB53_RS04830	COG1090	epimerase
EPB53_RS04835	COG0300	oxidoreductase activity
EPB53_RS04840	COG3118	belongs to the thioredoxin family
EPB53_RS04845	COG0330	HflC and HflK could
EPB53_RS04850	COG1585	Membrane protein implicated in regulation of membrane protease activity
EPB53_RS04855	COG0789	Transcriptional regulator
EPB53_RS04870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPB53_RS04875	COG3115	cell septum assembly
EPB53_RS04885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPB53_RS04895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB53_RS04905	COG2190	(PTS) system
EPB53_RS04910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB53_RS04915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPB53_RS04920	COG1702	phosphate starvation-inducible protein PhoH
EPB53_RS04930	COG4535	Mg2 and Co2 transporter CorC
EPB53_RS04935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPB53_RS04940	COG2888	peptidyl-tyrosine sulfation
EPB53_RS04950	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EPB53_RS04955	COG1466	dna polymerase III delta subunit
EPB53_RS04960	COG0799	negative regulation of ribosome biogenesis
EPB53_RS04965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EPB53_RS04970	COG0768	penicillin binding
EPB53_RS04975	COG0772	Belongs to the SEDS family
EPB53_RS04980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPB53_RS04985	COG1686	Belongs to the peptidase S11 family
EPB53_RS04990	COG2921	Belongs to the UPF0250 family
EPB53_RS04995	COG0321	lipoyl(octanoyl) transferase activity
EPB53_RS05000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPB53_RS05005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB53_RS05015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB53_RS05050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB53_RS05050	COG1263	PTS System
EPB53_RS05055	COG1609	Transcriptional regulator
EPB53_RS05060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB53_RS05065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPB53_RS05070	COG2011	ABC-type metal ion transport system permease component
EPB53_RS05075	COG1464	Belongs to the NlpA lipoprotein family
EPB53_RS05080	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EPB53_RS05090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB53_RS05090	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB53_RS05105	COG1611	Belongs to the LOG family
EPB53_RS05110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB53_RS05120	COG2363	Small membrane protein
EPB53_RS05130	COG0583	DNA-binding transcription factor activity
EPB53_RS05135	COG0301	tRNA thio-modification
EPB53_RS05135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB53_RS05145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB53_RS05150	COG1722	exodeoxyribonuclease VII activity
EPB53_RS05155	COG0142	geranyltranstransferase activity
EPB53_RS05160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPB53_RS05165	COG0564	pseudouridine synthase activity
EPB53_RS05170	COG3098	single-species biofilm formation
EPB53_RS05195	COG1671	Belongs to the UPF0178 family
EPB53_RS05200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB53_RS05205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPB53_RS05215	COG1720	tRNA m6t6A37 methyltransferase activity
EPB53_RS05220	COG0442	prolyl-tRNA aminoacylation
EPB53_RS05240	COG0047	phosphoribosylformylglycinamidine synthase activity
EPB53_RS05240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPB53_RS05245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EPB53_RS05255	COG0583	DNA-binding transcription factor activity
EPB53_RS05265	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EPB53_RS05270	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB53_RS05310	COG0484	heat shock protein binding
EPB53_RS05315	COG0443	Heat shock 70 kDa protein
EPB53_RS05320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPB53_RS05325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPB53_RS05330	COG0497	DNA recombination
EPB53_RS05335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB53_RS05340	COG2914	Belongs to the UPF0125 (RnfH) family
EPB53_RS05345	COG2867	negative regulation of translational initiation
EPB53_RS05360	COG0582	viral genome integration into host DNA
EPB53_RS05370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EPB53_RS05375	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EPB53_RS05385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPB53_RS05420	COG2003	Belongs to the UPF0758 family
EPB53_RS05450	COG1160	GTP binding
EPB53_RS05460	COG0328	RNA-DNA hybrid ribonuclease activity
EPB53_RS05495	COG1464	Belongs to the NlpA lipoprotein family
EPB53_RS05510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB53_RS05515	COG0840	transmembrane signaling receptor activity
EPB53_RS05635	COG2239	Acts as a magnesium transporter
EPB53_RS05645	COG2239	Acts as a magnesium transporter
EPB53_RS05660	COG0583	DNA-binding transcription factor activity
EPB53_RS05670	COG1115	amino acid carrier protein
EPB53_RS05680	COG0700	Nucleoside recognition
EPB53_RS05695	COG1584	GPR1 FUN34 yaaH family protein
EPB53_RS05700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB53_RS05715	COG0210	DNA helicase
EPB53_RS05730	COG0517	IMP dehydrogenase activity
EPB53_RS05730	COG0516	GMP reductase activity
EPB53_RS05735	COG1570	exodeoxyribonuclease VII activity
EPB53_RS05745	COG1160	GTP binding
EPB53_RS05750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB53_RS05755	COG2976	Protein conserved in bacteria
EPB53_RS05760	COG0124	histidyl-tRNA synthetase
EPB53_RS05765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPB53_RS05770	COG1426	Protein conserved in bacteria
EPB53_RS05780	COG0105	UTP biosynthetic process
EPB53_RS05785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB53_RS05790	COG1104	cysteine desulfurase activity
EPB53_RS05795	COG1959	2 iron, 2 sulfur cluster binding
EPB53_RS05800	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EPB53_RS05810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB53_RS05815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB53_RS05820	COG1862	Preprotein translocase
EPB53_RS05825	COG0343	queuine tRNA-ribosyltransferase activity
EPB53_RS05830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPB53_RS05835	COG0517	IMP dehydrogenase activity
EPB53_RS05845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPB53_RS05850	COG0583	DNA-binding transcription factor activity
EPB53_RS05855	COG0450	alkyl hydroperoxide reductase
EPB53_RS05865	COG0704	Plays a role in the regulation of phosphate uptake
EPB53_RS05870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB53_RS05875	COG0581	inorganic phosphate transmembrane transporter activity
EPB53_RS05880	COG0573	inorganic phosphate transmembrane transporter activity
EPB53_RS05885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPB53_RS05890	COG0248	Ppx GppA phosphatase
EPB53_RS05900	COG5002	protein histidine kinase activity
EPB53_RS05915	COG0826	peptidase U32
EPB53_RS05920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB53_RS05940	COG1595	DNA-templated transcription, initiation
EPB53_RS05950	COG3248	Nucleoside-binding outer membrane protein
EPB53_RS05955	COG0737	Belongs to the 5'-nucleotidase family
EPB53_RS05960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EPB53_RS05965	COG0693	protein deglycase activity
EPB53_RS05970	COG2166	iron-sulfur cluster assembly
EPB53_RS05975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPB53_RS05980	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EPB53_RS05990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB53_RS05990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB53_RS05995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB53_RS06015	COG0583	DNA-binding transcription factor activity
EPB53_RS06020	COG3141	response to X-ray
EPB53_RS06025	COG2171	N-acyltransferase activity
EPB53_RS06035	COG0189	ligase activity
EPB53_RS06035	COG0569	domain protein
EPB53_RS06050	COG2059	Chromate
EPB53_RS06065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB53_RS06070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPB53_RS06080	COG0560	Phosphoserine phosphatase
EPB53_RS06090	COG0813	purine-nucleoside phosphorylase activity
EPB53_RS06095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EPB53_RS06100	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EPB53_RS06105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EPB53_RS06110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB53_RS06115	COG0084	hydrolase, TatD family'
EPB53_RS06125	COG3022	response to hydroperoxide
EPB53_RS06130	COG1115	amino acid carrier protein
EPB53_RS06145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPB53_RS06150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EPB53_RS06155	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EPB53_RS06160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPB53_RS06165	COG0083	homoserine kinase activity
EPB53_RS06180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB53_RS06190	COG0745	RESPONSE REGULATOR receiver
EPB53_RS06200	COG0784	Response regulator, receiver
EPB53_RS06200	COG2198	Histidine kinase
EPB53_RS06200	COG5002	protein histidine kinase activity
EPB53_RS06205	COG1242	4 iron, 4 sulfur cluster binding
EPB53_RS06225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB53_RS06240	COG2860	membrane
EPB53_RS06245	COG0583	DNA-binding transcription factor activity
EPB53_RS06250	COG0730	response to heat
EPB53_RS06255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPB53_RS06260	COG0505	Belongs to the CarA family
EPB53_RS06265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EPB53_RS06270	COG0494	nUDIX hydrolase
EPB53_RS06275	COG0653	protein targeting
EPB53_RS06280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPB53_RS06285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPB53_RS06290	COG0849	cell division
EPB53_RS06295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPB53_RS06300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB53_RS06310	COG0772	Belongs to the SEDS family
EPB53_RS06315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPB53_RS06320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPB53_RS06325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPB53_RS06330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPB53_RS06335	COG0768	penicillin binding
EPB53_RS06340	COG3116	cell division
EPB53_RS06360	COG3107	peptidoglycan biosynthetic process
EPB53_RS06365	COG0792	nuclease activity
EPB53_RS06370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB53_RS06375	COG2823	Periplasmic or secreted lipoprotein
EPB53_RS06380	COG2969	positive regulation of protein catabolic process
EPB53_RS06385	COG0625	glutathione transferase activity
EPB53_RS06390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPB53_RS06395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPB53_RS06400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPB53_RS06410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPB53_RS06420	COG0335	large ribosomal subunit rRNA binding
EPB53_RS06425	COG0336	Belongs to the RNA methyltransferase TrmD family
EPB53_RS06430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPB53_RS06440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPB53_RS06445	COG4137	Cytochrome C assembly protein
EPB53_RS06450	COG4536	flavin adenine dinucleotide binding
EPB53_RS06455	COG1854	S-ribosylhomocysteine lyase activity
EPB53_RS06460	COG2918	glutathione biosynthetic process
EPB53_RS06465	COG0612	Peptidase, M16
EPB53_RS06470	COG1238	metal cluster binding
EPB53_RS06480	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPB53_RS06485	COG0511	ligase activity, forming carbon-carbon bonds
EPB53_RS06485	COG5016	pyruvate
EPB53_RS06490	COG3630	sodium ion export across plasma membrane
EPB53_RS06535	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EPB53_RS06540	COG0527	aspartate kinase activity
EPB53_RS06555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPB53_RS06560	COG1546	Belongs to the CinA family
EPB53_RS06565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EPB53_RS06570	COG4208	sulfate ABC transporter
EPB53_RS06595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPB53_RS06605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPB53_RS06615	COG0585	pseudouridine synthase activity
EPB53_RS06620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EPB53_RS06625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPB53_RS06630	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EPB53_RS06635	COG1968	undecaprenyl-diphosphatase activity
EPB53_RS06640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB53_RS06645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPB53_RS06650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPB53_RS06655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPB53_RS06660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPB53_RS06665	COG1610	YqeY-like protein
EPB53_RS06670	COG0358	DNA primase activity
EPB53_RS06705	COG3381	protein complex oligomerization
EPB53_RS06710	COG3302	dmso reductase anchor subunit
EPB53_RS06715	COG0437	4 iron, 4 sulfur cluster binding
EPB53_RS06720	COG0243	molybdopterin cofactor binding
EPB53_RS06725	COG2221	Nitrite and sulphite reductase 4Fe-4S
EPB53_RS06725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB53_RS06730	COG0584	glycerophosphoryl diester phosphodiesterase
EPB53_RS06825	COG1349	DNA-binding transcription factor activity
EPB53_RS06845	COG0583	DNA-binding transcription factor activity
EPB53_RS06855	COG0668	transmembrane transport
EPB53_RS06860	COG0191	fructose-bisphosphate aldolase activity
EPB53_RS06865	COG0126	phosphoglycerate kinase activity
EPB53_RS06870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB53_RS06875	COG4771	TonB-dependent receptor
EPB53_RS06880	COG0583	DNA-binding transcription factor activity
EPB53_RS06885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB53_RS06890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPB53_RS06900	COG2356	endonuclease I
EPB53_RS06905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPB53_RS06915	COG1678	Uncharacterized ACR, COG1678
EPB53_RS06920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPB53_RS06935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPB53_RS06940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EPB53_RS06945	COG0762	integral membrane protein
EPB53_RS06950	COG1872	DUF167
EPB53_RS06960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPB53_RS06965	COG2066	Belongs to the glutaminase family
EPB53_RS06970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPB53_RS06975	COG1194	a g-specific adenine glycosylase
EPB53_RS06980	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EPB53_RS06985	COG0741	lytic transglycosylase activity
EPB53_RS07035	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB53_RS07040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EPB53_RS07045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB53_RS07055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPB53_RS07060	COG2967	ApaG domain
EPB53_RS07080	COG2966	Psort location CytoplasmicMembrane, score
EPB53_RS07095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPB53_RS07100	COG0142	geranyltranstransferase activity
EPB53_RS07105	COG0531	amino acid
EPB53_RS07110	COG0039	L-malate dehydrogenase activity
EPB53_RS07115	COG1438	arginine binding
EPB53_RS07120	COG2358	TRAP transporter, solute receptor (TAXI family
EPB53_RS07130	COG0589	response to stress
EPB53_RS07150	COG0312	modulator of DNA gyrase
EPB53_RS07155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB53_RS07160	COG3164	Protein of unknown function
EPB53_RS07165	COG1530	ribonuclease E activity
EPB53_RS07170	COG0424	maF-like protein
EPB53_RS07175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPB53_RS07180	COG1792	Involved in formation and maintenance of cell shape
EPB53_RS07185	COG1077	Cell shape determining protein MreB Mrl
EPB53_RS07215	COG2165	general secretion pathway protein
EPB53_RS07240	COG3409	Peptidoglycan-binding domain 1 protein
EPB53_RS07240	COG3267	Type II secretory pathway component ExeA
EPB53_RS07245	COG1450	Type ii and iii secretion system protein
EPB53_RS07265	COG2200	EAL domain
EPB53_RS07265	COG2199	diguanylate cyclase activity
EPB53_RS07270	COG0629	single-stranded DNA binding
EPB53_RS07285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPB53_RS07295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPB53_RS07300	COG0527	aspartate kinase activity
EPB53_RS07350	COG0175	sulfate reduction
EPB53_RS07375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB53_RS07390	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB53_RS07395	COG0735	belongs to the Fur family
EPB53_RS07425	COG0359	binds to the 23S rRNA
EPB53_RS07435	COG0360	Binds together with S18 to 16S ribosomal RNA
EPB53_RS07445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB53_RS07450	COG0049	tRNA binding
EPB53_RS07460	COG2168	tRNA wobble position uridine thiolation
EPB53_RS07465	COG2923	Belongs to the DsrF TusC family
EPB53_RS07470	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EPB53_RS07475	COG2964	Protein conserved in bacteria
EPB53_RS07480	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB53_RS07490	COG2900	Belongs to the SlyX family
EPB53_RS07505	COG0330	HflC and HflK could
EPB53_RS07520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPB53_RS07525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPB53_RS07530	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPB53_RS07535	COG0802	atpase or kinase
EPB53_RS07540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPB53_RS07590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EPB53_RS07595	COG1162	GTPase activity
EPB53_RS07600	COG0688	phosphatidylethanolamine metabolic process
EPB53_RS07610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPB53_RS07620	COG4942	peptidase
EPB53_RS07640	COG2816	NAD+ diphosphatase activity
EPB53_RS07645	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EPB53_RS07650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EPB53_RS07655	COG0085	RNA polymerase activity
EPB53_RS07660	COG0222	ribosome binding
EPB53_RS07665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPB53_RS07670	COG0081	regulation of translation
EPB53_RS07675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EPB53_RS07685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB53_RS07715	COG1072	(Pantothenic acid kinase))
EPB53_RS07725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPB53_RS07735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB53_RS07790	COG3118	belongs to the thioredoxin family
EPB53_RS07795	COG0513	Belongs to the DEAD box helicase family
EPB53_RS07800	COG0248	Ppx GppA phosphatase
EPB53_RS07810	COG2814	Major facilitator Superfamily
EPB53_RS07825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB53_RS07830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPB53_RS07835	COG0511	ligase activity, forming carbon-carbon bonds
EPB53_RS07840	COG0439	Biotin carboxylase
EPB53_RS07855	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EPB53_RS07860	COG0583	DNA-binding transcription factor activity
EPB53_RS07870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB53_RS07880	COG2207	Transcriptional regulator
EPB53_RS07885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB53_RS07885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB53_RS07885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB53_RS07895	COG1982	Orn Lys Arg decarboxylase major
EPB53_RS07900	COG0531	amino acid
EPB53_RS07905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EPB53_RS07910	COG3710	Transcriptional regulator
EPB53_RS07925	COG0138	bifunctional purine biosynthesis protein purh
EPB53_RS07940	COG0776	regulation of translation
EPB53_RS07945	COG1253	flavin adenine dinucleotide binding
EPB53_RS07950	COG0668	transmembrane transport
EPB53_RS07960	COG0840	transmembrane signaling receptor activity
EPB53_RS07965	COG3842	ATPase activity
EPB53_RS07980	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB53_RS07985	COG2271	Major facilitator Superfamily
EPB53_RS07995	COG2197	response regulator
EPB53_RS08005	COG2197	response regulator
EPB53_RS08015	COG2271	Major facilitator Superfamily
EPB53_RS08030	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EPB53_RS08045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPB53_RS08075	COG1482	cell wall glycoprotein biosynthetic process
EPB53_RS08090	COG0662	Cupin 2, conserved barrel domain protein
EPB53_RS08090	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EPB53_RS08095	COG1051	belongs to the nudix hydrolase family
EPB53_RS08100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB53_RS08105	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EPB53_RS08130	COG1215	transferase activity, transferring glycosyl groups
EPB53_RS08130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EPB53_RS08150	COG2089	acid synthase
EPB53_RS08165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPB53_RS08170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPB53_RS08175	COG1086	Polysaccharide biosynthesis protein
EPB53_RS08195	COG5433	transposase activity
EPB53_RS08215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB53_RS08225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB53_RS08245	COG0859	PFAM glycosyl transferase family 9
EPB53_RS08250	COG1519	Transferase
EPB53_RS08260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB53_RS08265	COG0859	PFAM glycosyl transferase family 9
EPB53_RS08270	COG0463	Glycosyl transferase, family 2
EPB53_RS08280	COG0438	transferase activity, transferring glycosyl groups
EPB53_RS08285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPB53_RS08305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EPB53_RS08310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPB53_RS08315	COG2003	Belongs to the UPF0758 family
EPB53_RS08325	COG1309	transcriptional regulator
EPB53_RS08335	COG3275	phosphorelay sensor kinase activity
EPB53_RS08345	COG2223	nitrite transmembrane transporter activity
EPB53_RS08350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPB53_RS08355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EPB53_RS08360	COG1561	YicC-like family, N-terminal region
EPB53_RS08450	COG3012	SEC-C Motif Domain Protein
EPB53_RS08475	COG1289	transmembrane transporter activity
EPB53_RS08480	COG1566	PFAM secretion protein HlyD family protein
EPB53_RS08490	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EPB53_RS08500	COG5433	transposase activity
EPB53_RS08505	COG0612	Peptidase, M16
EPB53_RS08510	COG1228	amidohydrolase
EPB53_RS08515	COG2862	Uncharacterized protein family, UPF0114
EPB53_RS08525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPB53_RS08540	COG0514	ATP-dependent DNA helicase (RecQ)
EPB53_RS08545	COG2962	Rard protein
EPB53_RS08550	COG1280	lysine exporter protein (LysE YggA)
EPB53_RS08555	COG0210	DNA helicase
EPB53_RS08565	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPB53_RS08570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB53_RS08600	COG3335	DDE superfamily endonuclease
EPB53_RS08630	COG3335	DDE superfamily endonuclease
EPB53_RS08665	COG0515	serine threonine protein kinase
EPB53_RS08700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB53_RS08705	COG0601	transmembrane transport
EPB53_RS08710	COG0747	negative chemotaxis
EPB53_RS08750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB53_RS08755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB53_RS08760	COG2960	long-chain fatty acid transporting porin activity
EPB53_RS08770	COG0583	DNA-binding transcription factor activity
EPB53_RS08800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPB53_RS08820	COG0009	L-threonylcarbamoyladenylate synthase
EPB53_RS08825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPB53_RS08830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPB53_RS08835	COG3977	Valine--pyruvate aminotransferase
EPB53_RS08840	COG0751	glycine-tRNA ligase activity
EPB53_RS08845	COG0752	glycyl-tRNA synthetase alpha subunit
EPB53_RS08850	COG2119	membrane
EPB53_RS08860	COG0425	Belongs to the sulfur carrier protein TusA family
EPB53_RS08865	COG0604	alcohol dehydrogenase
EPB53_RS08880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPB53_RS08885	COG3978	acetolactate synthase activity
EPB53_RS08895	COG0606	chelatase, subunit chli
EPB53_RS08900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB53_RS08905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPB53_RS08910	COG3084	Protein conserved in bacteria
EPB53_RS08920	COG1272	protein, Hemolysin III
EPB53_RS08930	COG0569	domain protein
EPB53_RS08935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB53_RS08935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPB53_RS08945	COG0242	peptide deformylase activity
EPB53_RS08965	COG2922	Belongs to the Smg family
EPB53_RS08975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB53_RS08980	COG0745	RESPONSE REGULATOR receiver
EPB53_RS08990	COG5002	protein histidine kinase activity
EPB53_RS09000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EPB53_RS09005	COG0706	membrane insertase activity
EPB53_RS09015	COG0594	ribonuclease P activity
EPB53_RS09020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EPB53_RS09025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPB53_RS09030	COG0592	DNA-directed DNA polymerase activity
EPB53_RS09040	COG0187	DNA topoisomerase II activity
EPB53_RS09055	COG0071	Belongs to the small heat shock protein (HSP20) family
EPB53_RS09060	COG0445	tRNA wobble uridine modification
EPB53_RS09065	COG0357	Ribosomal RNA small subunit methyltransferase G
EPB53_RS09070	COG1192	Involved in chromosome partitioning
EPB53_RS09075	COG1475	DNA binding
EPB53_RS09080	COG3312	ion transport
EPB53_RS09085	COG0356	it plays a direct role in the translocation of protons across the membrane
EPB53_RS09095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EPB53_RS09105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPB53_RS09110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPB53_RS09115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPB53_RS09120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPB53_RS09130	COG2814	Major facilitator Superfamily
EPB53_RS09135	COG0583	DNA-binding transcription factor activity
EPB53_RS09140	COG0183	Belongs to the thiolase family
EPB53_RS09145	COG1024	Enoyl-CoA hydratase
EPB53_RS09145	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPB53_RS09150	COG1739	Uncharacterized protein family UPF0029
EPB53_RS09155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB53_RS09225	COG0038	chloride channel
EPB53_RS09230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EPB53_RS09240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB53_RS09250	COG2022	thiamine diphosphate biosynthetic process
EPB53_RS09255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPB53_RS09260	COG4175	Glycine betaine
EPB53_RS09280	COG1012	belongs to the aldehyde dehydrogenase family
EPB53_RS09285	COG1309	transcriptional regulator
EPB53_RS09290	COG0006	proline dipeptidase activity
EPB53_RS09290	COG0006	proline dipeptidase activity
EPB53_RS09310	COG1522	sequence-specific DNA binding
EPB53_RS09335	COG1528	Iron-storage protein
EPB53_RS09355	COG1322	Protein conserved in bacteria
EPB53_RS09360	COG2226	methyltransferase
EPB53_RS09375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB53_RS09380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB53_RS09385	COG0805	protein transport
EPB53_RS09390	COG0084	hydrolase, TatD family'
EPB53_RS09400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB53_RS09400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB53_RS09415	COG3078	GTPase activator activity
EPB53_RS09435	COG2959	enzyme of heme biosynthesis
EPB53_RS09440	COG1587	Uroporphyrinogen-III synthase
EPB53_RS09445	COG0181	hydroxymethylbilane synthase activity
EPB53_RS09450	COG3072	Adenylate cyclase
EPB53_RS09460	COG0019	diaminopimelate decarboxylase activity
EPB53_RS09465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EPB53_RS09475	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPB53_RS09480	COG1011	Hydrolase
EPB53_RS09485	COG2199	diguanylate cyclase activity
EPB53_RS09485	COG2200	EAL domain
EPB53_RS09485	COG3287	FIST C domain
EPB53_RS09490	COG3148	PFAM DTW domain containing protein
EPB53_RS09505	COG0561	phosphatase activity
EPB53_RS09515	COG0783	Belongs to the Dps family
EPB53_RS09545	COG2095	MarC family integral membrane protein
EPB53_RS09550	COG0742	ribosomal rna small subunit methyltransferase
EPB53_RS09555	COG0552	protein localization to endoplasmic reticulum
EPB53_RS09560	COG2884	Cell division ATP-binding protein ftsE
EPB53_RS09565	COG2177	Part of the ABC transporter FtsEX involved in
EPB53_RS09570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPB53_RS09590	COG3161	chorismate lyase activity
EPB53_RS09600	COG2937	Belongs to the GPAT DAPAT family
EPB53_RS09605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPB53_RS09615	COG0534	Mate efflux family protein
EPB53_RS09620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB53_RS09665	COG0328	RNA-DNA hybrid ribonuclease activity
EPB53_RS09730	COG2003	Belongs to the UPF0758 family
EPB53_RS09760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB53_RS09770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPB53_RS09825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB53_RS09830	COG2204	response regulator
EPB53_RS09835	COG3852	Histidine kinase
EPB53_RS09845	COG0174	glutamine synthetase
EPB53_RS09850	COG1217	gtp-binding protein TYPA
EPB53_RS09860	COG1490	D-aminoacyl-tRNA deacylase activity
EPB53_RS09865	COG0456	acetyltransferase
EPB53_RS09875	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EPB53_RS09880	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EPB53_RS09885	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPB53_RS09890	COG3031	protein transport across the cell outer membrane
EPB53_RS09900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB53_RS09905	COG1459	type II secretion system
EPB53_RS09910	COG2165	general secretion pathway protein
EPB53_RS09915	COG2165	general secretion pathway protein
EPB53_RS09920	COG2165	general secretion pathway protein
EPB53_RS09925	COG4795	General secretion pathway protein
EPB53_RS09930	COG3156	type II secretion system protein K
EPB53_RS09935	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB53_RS09940	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB53_RS09950	COG1218	3'(2'),5'-bisphosphate nucleotidase
EPB53_RS09955	COG0494	nUDIX hydrolase
EPB53_RS09970	COG0596	Alpha beta hydrolase
EPB53_RS09980	COG2183	response to ionizing radiation
EPB53_RS09990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB53_RS09995	COG1609	Transcriptional regulator
EPB53_RS10000	COG0129	dihydroxy-acid dehydratase activity
EPB53_RS10005	COG3265	gluconokinase activity
EPB53_RS10010	COG2610	gluconate transmembrane transporter activity
EPB53_RS10030	COG2233	PERMEase
EPB53_RS10035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPB53_RS10040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB53_RS10045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB53_RS10055	COG0194	GDP metabolic process
EPB53_RS10060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EPB53_RS10070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB53_RS10095	COG4232	protein-disulfide reductase activity
EPB53_RS10105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPB53_RS10120	COG1288	antiporter activity
EPB53_RS10125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB53_RS10130	COG1027	Aspartate ammonia-lyase
EPB53_RS10135	COG3030	protein affecting phage T7 exclusion by the F plasmid
EPB53_RS10140	COG1278	Cold shock
EPB53_RS10150	COG2205	protein histidine kinase activity
EPB53_RS10155	COG0745	RESPONSE REGULATOR receiver
EPB53_RS10165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EPB53_RS10170	COG0205	6-phosphofructokinase activity
EPB53_RS10175	COG1494	fructose-1,6-bisphosphatase
EPB53_RS10180	COG3074	FtsZ-dependent cytokinesis
EPB53_RS10185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPB53_RS10195	COG0626	cystathionine gamma-synthase activity
EPB53_RS10200	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EPB53_RS10205	COG0281	malic enzyme
EPB53_RS10215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPB53_RS10230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EPB53_RS10235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EPB53_RS10240	COG1575	Belongs to the MenA family. Type 1 subfamily
EPB53_RS10245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB53_RS10250	COG0534	Mate efflux family protein
EPB53_RS10255	COG0149	triose-phosphate isomerase activity
EPB53_RS10280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPB53_RS10285	COG0459	protein refolding
EPB53_RS10295	COG1285	pathogenesis
EPB53_RS10300	COG1509	lysine 2,3-aminomutase activity
EPB53_RS10305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPB53_RS10315	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EPB53_RS10320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB53_RS10325	COG1053	succinate dehydrogenase
EPB53_RS10330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EPB53_RS10335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB53_RS10340	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EPB53_RS10350	COG1045	serine acetyltransferase
EPB53_RS10365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB53_RS10370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPB53_RS10375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB53_RS10380	COG0137	argininosuccinate synthase activity
EPB53_RS10385	COG0165	Argininosuccinate lyase
EPB53_RS10385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB53_RS10400	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPB53_RS10430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPB53_RS10445	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EPB53_RS10455	COG0546	phosphoglycolate phosphatase activity
EPB53_RS10460	COG0180	Tryptophanyl-tRNA synthetase
EPB53_RS10470	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB53_RS10475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPB53_RS10500	COG3954	Phosphoribulokinase
EPB53_RS10510	COG0429	hydrolase of the alpha beta-hydrolase fold
EPB53_RS10520	COG0488	(ABC) transporter
EPB53_RS10525	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB53_RS10540	COG1047	Peptidyl-prolyl cis-trans
EPB53_RS10545	COG1446	asparaginase
EPB53_RS10550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB53_RS10555	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EPB53_RS10560	COG0557	exoribonuclease II activity
EPB53_RS10565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB53_RS10570	COG0051	transcription antitermination factor activity, RNA binding
EPB53_RS10575	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPB53_RS10580	COG0088	Forms part of the polypeptide exit tunnel
EPB53_RS10585	COG0089	rRNA binding
EPB53_RS10590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPB53_RS10595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPB53_RS10600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPB53_RS10605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EPB53_RS10610	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EPB53_RS10615	COG0255	Belongs to the universal ribosomal protein uL29 family
EPB53_RS10620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPB53_RS10625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EPB53_RS10635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPB53_RS10640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPB53_RS10645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPB53_RS10660	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EPB53_RS10665	COG1841	ribosomal large subunit assembly
EPB53_RS10670	COG0200	Binds to the 23S rRNA
EPB53_RS10675	COG0201	protein transport
EPB53_RS10680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPB53_RS10685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPB53_RS10690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPB53_RS10695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EPB53_RS10700	COG0202	RNA polymerase activity
EPB53_RS10705	COG0203	ribosomal protein L17
EPB53_RS10715	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB53_RS10725	COG2153	protein acetylation
EPB53_RS10730	COG0513	Belongs to the DEAD box helicase family
EPB53_RS10745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPB53_RS10745	COG1648	precorrin-2 dehydrogenase activity
EPB53_RS10750	COG0175	sulfate reduction
EPB53_RS10755	COG2895	sulfate adenylyltransferase (ATP) activity
EPB53_RS10760	COG0529	Catalyzes the synthesis of activated sulfate
EPB53_RS10780	COG1136	(ABC) transporter
EPB53_RS10780	COG0577	efflux transmembrane transporter activity
EPB53_RS10795	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EPB53_RS10805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB53_RS10810	COG0729	surface antigen
EPB53_RS10820	COG2105	PFAM AIG2 family protein
EPB53_RS10825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPB53_RS10830	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPB53_RS10835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB53_RS10840	COG0163	prenyltransferase activity
EPB53_RS10845	COG4143	(ABC) transporter
EPB53_RS10855	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EPB53_RS10860	COG3028	Belongs to the UPF0307 family
EPB53_RS10865	COG0312	modulator of DNA gyrase
EPB53_RS10875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB53_RS10880	COG1660	Displays ATPase and GTPase activities
EPB53_RS10885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB53_RS10890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB53_RS10900	COG1137	ATPase activity
EPB53_RS10905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPB53_RS10915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EPB53_RS10930	COG1127	ABC transporter
EPB53_RS10935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPB53_RS10940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB53_RS10945	COG2854	intermembrane phospholipid transfer
EPB53_RS10955	COG5007	Belongs to the BolA IbaG family
EPB53_RS10960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPB53_RS10970	COG0251	oxidation-reduction process
EPB53_RS10980	COG0540	Belongs to the ATCase OTCase family
EPB53_RS10985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPB53_RS10990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EPB53_RS10995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPB53_RS11010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB53_RS11015	COG0525	valine-tRNA ligase activity
EPB53_RS11020	COG2927	DNA polymerase III (CHI subunit)
EPB53_RS11025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB53_RS11095	COG0066	3-isopropylmalate dehydratase activity
EPB53_RS11100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPB53_RS11105	COG0473	3-isopropylmalate dehydrogenase activity
EPB53_RS11115	COG0671	phosphoesterase, PA-phosphatase related
EPB53_RS11125	COG0583	DNA-binding transcription factor activity
EPB53_RS11130	COG1022	Amp-dependent synthetase and ligase
EPB53_RS11135	COG0028	Belongs to the TPP enzyme family
EPB53_RS11145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB53_RS11150	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EPB53_RS11155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPB53_RS11165	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EPB53_RS11170	COG3079	Belongs to the UPF0149 family
EPB53_RS11175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB53_RS11180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB53_RS11210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPB53_RS11215	COG1595	DNA-templated transcription, initiation
EPB53_RS11225	COG3026	antisigma factor binding
EPB53_RS11230	COG3086	response to oxidative stress
EPB53_RS11235	COG0481	GTPase activity
EPB53_RS11245	COG0571	ribonuclease III activity
EPB53_RS11255	COG1381	Involved in DNA repair and RecF pathway recombination
EPB53_RS11260	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPB53_RS11275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB53_RS11285	COG3956	TIGRFAM MazG family protein
EPB53_RS11290	COG0504	CTP synthase activity
EPB53_RS11300	COG0617	tRNA 3'-terminal CCA addition
EPB53_RS11305	COG4991	sh3 domain protein
EPB53_RS11315	COG1392	Phosphate transport regulator
EPB53_RS11320	COG3025	triphosphatase activity
EPB53_RS11340	COG1538	Outer membrane efflux protein
EPB53_RS11345	COG0494	nUDIX hydrolase
EPB53_RS11350	COG3151	Protein conserved in bacteria
EPB53_RS11360	COG3150	esterase
EPB53_RS11365	COG0187	DNA topoisomerase II activity
EPB53_RS11380	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EPB53_RS11395	COG1459	type II secretion system
EPB53_RS11400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB53_RS11410	COG0157	Belongs to the NadC ModD family
EPB53_RS11415	COG3023	N-Acetylmuramoyl-L-alanine amidase
EPB53_RS11420	COG0716	FMN binding
EPB53_RS11425	COG4974	Belongs to the 'phage' integrase family
EPB53_RS11430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB53_RS11440	COG2186	Transcriptional regulator
EPB53_RS11450	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB53_RS11455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB53_RS11470	COG0288	reversible hydration of carbon dioxide
EPB53_RS11475	COG1131	(ABC) transporter
EPB53_RS11485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPB53_RS11490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPB53_RS11505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB53_RS11510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPB53_RS11520	COG1643	Atp-dependent helicase
EPB53_RS11525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB53_RS11530	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPB53_RS11570	COG1121	(ABC) transporter
EPB53_RS11575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB53_RS11585	COG0745	RESPONSE REGULATOR receiver
EPB53_RS11595	COG4771	TonB-dependent receptor
EPB53_RS11600	COG4771	TonB-dependent receptor
EPB53_RS11605	COG1929	Belongs to the glycerate kinase type-1 family
EPB53_RS11610	COG3112	Uncharacterised protein family (UPF0231)
EPB53_RS11615	COG0347	Belongs to the P(II) protein family
EPB53_RS11620	COG0004	ammonium transporteR
EPB53_RS11625	COG3842	ATPase activity
EPB53_RS11635	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB53_RS11640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB53_RS11660	COG4608	Belongs to the ABC transporter superfamily
EPB53_RS11665	COG0444	Belongs to the ABC transporter superfamily
EPB53_RS11680	COG0747	negative chemotaxis
EPB53_RS11685	COG2205	protein histidine kinase activity
EPB53_RS11685	COG0784	Response regulator, receiver
EPB53_RS11685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB53_RS11685	COG2198	Histidine kinase
EPB53_RS11700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPB53_RS11710	COG0739	heme binding
EPB53_RS11715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB53_RS11720	COG2027	D-alanyl-D-alanine carboxypeptidase
EPB53_RS11725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB53_RS11730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB53_RS11735	COG1534	Rna-binding protein
EPB53_RS11740	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EPB53_RS11750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPB53_RS11755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB53_RS11760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB53_RS11780	COG0195	Participates in both transcription termination and antitermination
EPB53_RS11785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPB53_RS11790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPB53_RS11800	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPB53_RS11805	COG1185	polyribonucleotide nucleotidyltransferase activity
EPB53_RS11815	COG0826	peptidase U32
EPB53_RS11820	COG0826	peptidase U32
EPB53_RS11830	COG3154	lipid carrier protein
EPB53_RS11835	COG3153	acetyltransferase
EPB53_RS11860	COG0513	Belongs to the DEAD box helicase family
EPB53_RS11880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPB53_RS11890	COG0667	Aldo Keto reductase
EPB53_RS11900	COG0494	nUDIX hydrolase
EPB53_RS11910	COG0730	response to heat
EPB53_RS11920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPB53_RS11925	COG1283	sodium-dependent phosphate transmembrane transporter activity
EPB53_RS11930	COG0583	DNA-binding transcription factor activity
EPB53_RS11935	COG0640	Transcriptional regulator
EPB53_RS11940	COG0268	Binds directly to 16S ribosomal RNA
EPB53_RS11945	COG0728	peptidoglycan biosynthetic process
EPB53_RS11960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EPB53_RS11965	COG1047	Peptidyl-prolyl cis-trans
EPB53_RS11970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPB53_RS11975	COG1966	Carbon starvation protein
EPB53_RS11985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPB53_RS11995	COG3279	Response regulator of the LytR AlgR family
EPB53_RS12000	COG3275	phosphorelay sensor kinase activity
EPB53_RS12010	COG1605	Chorismate mutase
EPB53_RS12010	COG0287	Prephenate dehydrogenase
EPB53_RS12030	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EPB53_RS12040	COG1605	Chorismate mutase
EPB53_RS12040	COG0077	Prephenate dehydratase
EPB53_RS12045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB53_RS12050	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB53_RS12055	COG0564	pseudouridine synthase activity
EPB53_RS12065	COG0542	response to heat
EPB53_RS12140	COG2813	Specifically methylates the guanine in position
EPB53_RS12145	COG0271	Belongs to the BolA IbaG family
EPB53_RS12150	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB53_RS12155	COG1805	sodium ion transport
EPB53_RS12160	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB53_RS12165	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB53_RS12170	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB53_RS12180	COG1477	protein flavinylation
EPB53_RS12190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPB53_RS12200	COG0733	neurotransmitter:sodium symporter activity
EPB53_RS12210	COG0189	ligase activity
EPB53_RS12215	COG4067	protein conserved in archaea
EPB53_RS12215	COG0189	ligase activity
EPB53_RS12220	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB53_RS12225	COG2252	PERMEase
EPB53_RS12230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EPB53_RS12235	COG1073	alpha beta
EPB53_RS12245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EPB53_RS12250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPB53_RS12255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPB53_RS12260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB53_RS12260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB53_RS12275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EPB53_RS12280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB53_RS12290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EPB53_RS12300	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EPB53_RS12305	COG0024	Methionine aminopeptidase
EPB53_RS12310	COG0052	Belongs to the universal ribosomal protein uS2 family
EPB53_RS12315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPB53_RS12325	COG0233	cytoplasmic translational termination
EPB53_RS12330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPB53_RS12335	COG0575	Belongs to the CDS family
EPB53_RS12340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPB53_RS12345	COG0750	zinc metalloprotease
EPB53_RS12355	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EPB53_RS12360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB53_RS12365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB53_RS12370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB53_RS12375	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB53_RS12380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPB53_RS12385	COG0587	DNA-directed DNA polymerase activity
EPB53_RS12395	COG0037	tRNA processing
EPB53_RS12400	COG0347	Belongs to the P(II) protein family
EPB53_RS12405	COG3021	interspecies interaction between organisms
EPB53_RS12425	COG1388	LysM domain
EPB53_RS12425	COG0741	lytic transglycosylase activity
EPB53_RS12430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB53_RS12435	COG2226	methyltransferase
EPB53_RS12440	COG0328	RNA-DNA hybrid ribonuclease activity
EPB53_RS12460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB53_RS12465	COG0121	glutamine amidotransferase
EPB53_RS12470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPB53_RS12475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EPB53_RS12480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPB53_RS12490	COG2840	Smr protein MutS2
EPB53_RS12510	COG2608	mercury ion transmembrane transporter activity
EPB53_RS12510	COG2217	Heavy metal translocating P-type atpase
EPB53_RS12515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB53_RS12555	COG2747	anti-sigma28 factor FlgM
EPB53_RS12565	COG0784	Response regulator, receiver
EPB53_RS12565	COG0835	chemotaxis
EPB53_RS12570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPB53_RS12575	COG1815	bacterial-type flagellum-dependent cell motility
EPB53_RS12590	COG1749	Flagellar hook protein flgE
EPB53_RS12595	COG4787	bacterial-type flagellum-dependent cell motility
EPB53_RS12605	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB53_RS12610	COG1706	bacterial-type flagellum-dependent cell motility
EPB53_RS12615	COG3951	Flagellar rod assembly protein muramidase FlgJ
EPB53_RS12615	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPB53_RS12630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB53_RS12635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB53_RS12715	COG0012	GTP binding
EPB53_RS12725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPB53_RS12730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EPB53_RS12735	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EPB53_RS12745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPB53_RS12750	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB53_RS12760	COG2912	Transglutaminase-like superfamily
EPB53_RS12790	COG1393	Belongs to the ArsC family
EPB53_RS12795	COG4783	chaperone-mediated protein folding
EPB53_RS12815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPB53_RS12820	COG2716	regulation of RNA biosynthetic process
EPB53_RS12840	COG1876	peptidase activity
EPB53_RS12850	COG1393	Belongs to the ArsC family
EPB53_RS12875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB53_RS12880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB53_RS12885	COG1334	flagellar protein FlaG
EPB53_RS12890	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB53_RS12900	COG1516	flagellar protein fliS
EPB53_RS12920	COG1677	Flagellar hook-basal body complex protein FliE
EPB53_RS12930	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPB53_RS12980	COG1987	bacterial-type flagellum assembly
EPB53_RS12995	COG2840	Smr protein MutS2
EPB53_RS13000	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB53_RS13005	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPB53_RS13010	COG2860	membrane
EPB53_RS13015	COG3101	peptidyl-lysine hydroxylation
EPB53_RS13025	COG0431	NADPH-dependent FMN reductase
EPB53_RS13035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB53_RS13040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB53_RS13045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB53_RS13050	COG0735	belongs to the Fur family
EPB53_RS13060	COG0583	DNA-binding transcription factor activity
EPB53_RS13065	COG1380	Effector of murein hydrolase LrgA
EPB53_RS13070	COG1346	cytolysis
EPB53_RS13080	COG0596	Alpha beta hydrolase
EPB53_RS13085	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EPB53_RS13090	COG0033	Phosphoglucomutase
EPB53_RS13115	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPB53_RS13130	COG0567	Dehydrogenase, E1 component
EPB53_RS13160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB53_RS13165	COG1121	(ABC) transporter
EPB53_RS13170	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EPB53_RS13180	COG1918	ferrous iron import across plasma membrane
EPB53_RS13185	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EPB53_RS13205	COG3102	Protein conserved in bacteria
EPB53_RS13210	COG1025	Belongs to the peptidase M16 family
EPB53_RS13215	COG2062	phosphohistidine phosphatase, SixA
EPB53_RS13245	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EPB53_RS13250	COG0643	Histidine kinase
EPB53_RS13250	COG2198	Histidine kinase
EPB53_RS13250	COG0784	Response regulator, receiver
EPB53_RS13270	COG0835	chemotaxis
EPB53_RS13280	COG2853	Lipoprotein
EPB53_RS13300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPB53_RS13315	COG0840	transmembrane signaling receptor activity
EPB53_RS13320	COG3639	organic phosphonate transmembrane transporter activity
EPB53_RS13325	COG3639	organic phosphonate transmembrane transporter activity
EPB53_RS13330	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EPB53_RS13360	COG0488	(ABC) transporter
EPB53_RS13365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB53_RS13375	COG2130	NADP-dependent
EPB53_RS13380	COG1309	transcriptional regulator
EPB53_RS13410	COG1013	pyruvate-flavodoxin oxidoreductase activity
EPB53_RS13410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EPB53_RS13410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPB53_RS13410	COG0674	pyruvate-flavodoxin oxidoreductase activity
EPB53_RS13415	COG2205	protein histidine kinase activity
EPB53_RS13420	COG0745	RESPONSE REGULATOR receiver
EPB53_RS13425	COG3122	Protein conserved in bacteria
EPB53_RS13440	COG2226	methyltransferase
EPB53_RS13450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB53_RS13455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB53_RS13465	COG3139	Protein of unknown function (DUF1315)
EPB53_RS13470	COG0252	asparaginase activity
EPB53_RS13475	COG0616	signal peptide processing
EPB53_RS13480	COG1902	pentaerythritol trinitrate reductase activity
EPB53_RS13480	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB53_RS13485	COG0788	formyltetrahydrofolate deformylase activity
EPB53_RS13495	COG1199	ATP-dependent helicase activity
EPB53_RS13500	COG1214	PFAM Peptidase M22, glycoprotease
EPB53_RS13515	COG1073	alpha beta
EPB53_RS13515	COG2226	methyltransferase
EPB53_RS13520	COG0318	PFAM AMP-dependent synthetase and ligase
EPB53_RS13525	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EPB53_RS13530	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EPB53_RS13535	COG2894	cell division
EPB53_RS13540	COG0850	regulation of cytokinetic process
EPB53_RS13545	COG3100	YcgL domain-containing protein
EPB53_RS13550	COG2951	lytic endotransglycosylase activity
EPB53_RS13555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EPB53_RS13560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPB53_RS13565	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPB53_RS13575	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EPB53_RS13580	COG0314	molybdopterin synthase activity
EPB53_RS13585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EPB53_RS13585	COG0517	IMP dehydrogenase activity
EPB53_RS13585	COG0617	tRNA 3'-terminal CCA addition
EPB53_RS13605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB53_RS13605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB53_RS13615	COG0572	uridine kinase
EPB53_RS13620	COG2982	Protein involved in outer membrane biogenesis
EPB53_RS13625	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EPB53_RS13630	COG2067	long-chain fatty acid transport protein
EPB53_RS13640	COG0183	Belongs to the thiolase family
EPB53_RS13650	COG0583	DNA-binding transcription factor activity
EPB53_RS13655	COG0745	RESPONSE REGULATOR receiver
EPB53_RS13660	COG2832	Protein of unknown function (DUF454)
EPB53_RS13665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPB53_RS13675	COG0010	Belongs to the arginase family
EPB53_RS13680	COG1166	arginine decarboxylase activity
EPB53_RS13695	COG0748	coenzyme F420 binding
EPB53_RS13705	COG4558	Periplasmic binding protein
EPB53_RS13710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB53_RS13715	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EPB53_RS13745	COG3217	Mosc domain protein beta barrel domain protein
EPB53_RS13745	COG0633	Ferredoxin
EPB53_RS13750	COG0418	dihydroorotase activity
EPB53_RS13770	COG1349	DNA-binding transcription factor activity
EPB53_RS13785	COG1607	acyl-coa hydrolase
EPB53_RS13805	COG3833	ABC-type maltose transport systems, permease component
EPB53_RS13810	COG1175	transmembrane transport
EPB53_RS13820	COG3842	ATPase activity
EPB53_RS13830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB53_RS13835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB53_RS13850	COG1461	Dihydroxyacetone kinase
EPB53_RS13860	COG2376	Dihydroxyacetone kinase
EPB53_RS13880	COG1063	alcohol dehydrogenase
EPB53_RS13885	COG0156	8-amino-7-oxononanoate synthase activity
EPB53_RS13890	COG3240	lipase activity
EPB53_RS13915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPB53_RS13925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPB53_RS13930	COG0363	glucosamine-6-phosphate deaminase activity
EPB53_RS13935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB53_RS13960	COG0783	Belongs to the Dps family
EPB53_RS13965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPB53_RS13970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB53_RS13970	COG2205	protein histidine kinase activity
EPB53_RS13975	COG2197	response regulator
EPB53_RS14020	COG2199	diguanylate cyclase activity
EPB53_RS14020	COG2200	EAL domain
EPB53_RS14020	COG2202	Pas domain
EPB53_RS14025	COG3876	Protein conserved in bacteria
EPB53_RS14030	COG1472	Belongs to the glycosyl hydrolase 3 family
EPB53_RS14035	COG0673	inositol 2-dehydrogenase activity
EPB53_RS14040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EPB53_RS14055	COG1342	Belongs to the UPF0251 family
EPB53_RS14060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EPB53_RS14075	COG0786	glutamate:sodium symporter activity
EPB53_RS14085	COG0415	Belongs to the DNA photolyase family
EPB53_RS14090	COG0789	Transcriptional regulator
EPB53_RS14095	COG3272	Protein of unknown function (DUF1722)
EPB53_RS14100	COG0813	purine-nucleoside phosphorylase activity
EPB53_RS14130	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EPB53_RS14145	COG4580	involved in the transport of maltose and maltodextrins
EPB53_RS14155	COG1132	(ABC) transporter
EPB53_RS14165	COG0671	phosphoesterase, PA-phosphatase related
EPB53_RS14170	COG0010	Belongs to the arginase family
EPB53_RS14185	COG0840	transmembrane signaling receptor activity
EPB53_RS14195	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB53_RS14200	COG0471	metal ion transport
EPB53_RS14210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPB53_RS14215	COG1640	4-alpha-glucanotransferase
EPB53_RS14220	COG0058	SHG alpha-glucan phosphorylase activity
EPB53_RS14225	COG2909	trisaccharide binding
EPB53_RS14255	COG3046	protein related to deoxyribodipyrimidine photolyase
EPB53_RS14265	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB53_RS14270	COG1444	tRNA N-acetyltransferase activity
EPB53_RS14275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EPB53_RS14305	COG0217	transcriptional regulatory protein
EPB53_RS14310	COG2084	Dehydrogenase
EPB53_RS14325	COG0259	pyridoxamine-phosphate oxidase activity
EPB53_RS14365	COG0513	Belongs to the DEAD box helicase family
EPB53_RS14375	COG0840	transmembrane signaling receptor activity
EPB53_RS14380	COG0583	DNA-binding transcription factor activity
EPB53_RS14385	COG0702	epimerase
EPB53_RS14395	COG2076	Multidrug Resistance protein
EPB53_RS14410	COG4628	conserved protein (DUF2132)
EPB53_RS14415	COG0477	Major facilitator Superfamily
EPB53_RS14425	COG0095	Lipoate-protein ligase
EPB53_RS14435	COG5002	protein histidine kinase activity
EPB53_RS14445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB53_RS14455	COG3722	fumarate hydratase activity
EPB53_RS14465	COG2213	PTS system mannitol-specific
EPB53_RS14465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB53_RS14470	COG0739	heme binding
EPB53_RS14480	COG0564	pseudouridine synthase activity
EPB53_RS14500	COG1869	D-ribose catabolic process
EPB53_RS14505	COG1129	ABC transporter
EPB53_RS14510	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB53_RS14515	COG1879	ABC-type sugar transport system periplasmic component
EPB53_RS14520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB53_RS14525	COG1609	Transcriptional regulator
EPB53_RS14530	COG0584	glycerophosphoryl diester phosphodiesterase
EPB53_RS14535	COG2271	Major facilitator Superfamily
EPB53_RS14550	COG0583	DNA-binding transcription factor activity
EPB53_RS14555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB53_RS14560	COG3530	Putative quorum-sensing-regulated virulence factor
EPB53_RS14575	COG2184	nucleotidyltransferase activity
EPB53_RS14580	COG1349	DNA-binding transcription factor activity
EPB53_RS14590	COG2222	sugar isomerase
EPB53_RS14605	COG3716	PTS system mannose fructose sorbose family IID component
EPB53_RS14610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB53_RS14625	COG1501	Belongs to the glycosyl hydrolase 31 family
EPB53_RS14630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPB53_RS14640	COG0513	Belongs to the DEAD box helicase family
EPB53_RS14655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB53_RS14665	COG3724	N-succinylarginine dihydrolase activity
EPB53_RS14705	COG0840	transmembrane signaling receptor activity
EPB53_RS14720	COG0366	Alpha amylase catalytic
EPB53_RS14725	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB53_RS14735	COG3604	Transcriptional regulator
EPB53_RS14740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB53_RS14740	COG1017	nitric oxide dioxygenase activity
EPB53_RS14745	COG1278	Cold shock
EPB53_RS14755	COG2201	protein-glutamate methylesterase activity
EPB53_RS14765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPB53_RS14765	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPB53_RS14770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB53_RS14775	COG0516	GMP reductase activity
EPB53_RS14780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB53_RS14800	COG2382	esterase
EPB53_RS14815	COG1120	ATPase activity
EPB53_RS14820	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB53_RS14835	COG4592	Periplasmic binding protein
EPB53_RS14840	COG3433	isochorismatase activity
EPB53_RS14840	COG1535	isochorismatase
EPB53_RS14845	COG1021	2,3-dihydroxybenzoate-AMP ligase
EPB53_RS14850	COG1169	isochorismate synthase
EPB53_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
EPB53_RS14860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB53_RS14865	COG2977	Belongs to the P-Pant transferase superfamily
EPB53_RS14875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB53_RS14900	COG0583	DNA-binding transcription factor activity
EPB53_RS14910	COG4628	conserved protein (DUF2132)
EPB53_RS14915	COG1957	nucleoside hydrolase
EPB53_RS14945	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPB53_RS14950	COG0811	peptide transport
EPB53_RS14955	COG0848	biopolymer transport protein
EPB53_RS14965	COG2814	Major facilitator Superfamily
EPB53_RS14970	COG1054	Belongs to the UPF0176 family
EPB53_RS14975	COG2259	Doxx family
EPB53_RS14985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB53_RS14995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB53_RS15005	COG2200	EAL domain
EPB53_RS15005	COG2771	luxR family
EPB53_RS15015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB53_RS15025	COG0363	glucosamine-6-phosphate deaminase activity
EPB53_RS15050	COG0513	Belongs to the DEAD box helicase family
EPB53_RS15055	COG3314	Sporulation integral membrane protein YlbJ
EPB53_RS15070	COG0739	heme binding
EPB53_RS15075	COG5001	Diguanylate cyclase
EPB53_RS15095	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPB53_RS15100	COG1280	lysine exporter protein (LysE YggA)
EPB53_RS15105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB53_RS15110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB53_RS15130	COG0583	DNA-binding transcription factor activity
EPB53_RS15140	COG1067	ATP-dependent peptidase activity
EPB53_RS15150	COG3123	guanosine phosphorylase activity
EPB53_RS15155	COG1741	Belongs to the pirin family
EPB53_RS15170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPB53_RS15180	COG0835	chemotaxis
EPB53_RS15180	COG0784	Response regulator, receiver
EPB53_RS15185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB53_RS15190	COG3047	cAMP biosynthetic process
EPB53_RS15195	COG2267	carboxylic ester hydrolase activity
EPB53_RS15200	COG2067	long-chain fatty acid transport protein
EPB53_RS15205	COG0366	Alpha amylase catalytic
EPB53_RS15215	COG4989	oxidoreductase activity
EPB53_RS15220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB53_RS15225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPB53_RS15230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EPB53_RS15250	COG4607	ABC-type enterochelin transport system periplasmic component
EPB53_RS15255	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB53_RS15260	COG4605	iron ion homeostasis
EPB53_RS15265	COG4604	ABC transporter, ATP-binding protein
EPB53_RS15270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB53_RS15275	COG4145	pantothenate transmembrane transporter activity
EPB53_RS15290	COG1278	Cold shock
EPB53_RS15295	COG0625	glutathione transferase activity
EPB53_RS15310	COG3328	transposase activity
EPB53_RS15325	COG1765	OsmC-like protein
EPB53_RS15350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB53_RS15355	COG3186	Phenylalanine-4-hydroxylase
EPB53_RS15360	COG2154	pterin-4-alpha-carbinolamine dehydratase
EPB53_RS15365	COG0456	acetyltransferase
EPB53_RS15370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB53_RS15375	COG0662	Cupin 2, conserved barrel domain protein
EPB53_RS15380	COG0527	aspartate kinase activity
EPB53_RS15405	COG0444	Belongs to the ABC transporter superfamily
EPB53_RS15450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPB53_RS15475	COG5433	transposase activity
EPB53_RS15480	COG5433	transposase activity
EPB53_RS15505	COG5433	transposase activity
EPB53_RS15545	COG1794	racemase activity, acting on amino acids and derivatives
EPB53_RS15550	COG5433	transposase activity
EPB53_RS15555	COG5433	transposase activity
EPB53_RS15580	COG5433	transposase activity
EPB53_RS15660	COG0242	peptide deformylase activity
EPB53_RS15770	COG5433	transposase activity
EPB53_RS15800	COG2161	toxin-antitoxin pair type II binding
EPB53_RS15805	COG4115	mRNA cleavage
EPB53_RS15895	COG3041	Addiction module toxin RelE StbE family
EPB53_RS15910	COG0110	maltose O-acetyltransferase activity
EPB53_RS15940	COG0346	lactoylglutathione lyase activity
EPB53_RS15970	COG0454	-acetyltransferase
EPB53_RS15985	COG2026	Addiction module toxin, RelE StbE family
EPB53_RS16005	COG0582	viral genome integration into host DNA
EPB53_RS16035	COG3328	transposase activity
EPB53_RS16055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPB53_RS16080	COG0384	phenazine biosynthesis protein PhzF
EPB53_RS16135	COG2026	Addiction module toxin, RelE StbE family
EPB53_RS16150	COG1028	Short-chain dehydrogenase reductase Sdr
EPB53_RS16190	COG3041	Addiction module toxin RelE StbE family
EPB53_RS16265	COG3041	Addiction module toxin RelE StbE family
EPB53_RS16335	COG5433	transposase activity
EPB53_RS16370	COG0242	peptide deformylase activity
EPB53_RS16475	COG5433	transposase activity
EPB53_RS16535	COG3328	transposase activity
EPB53_RS16560	COG3041	Addiction module toxin RelE StbE family
EPB53_RS16580	COG5433	transposase activity
EPB53_RS16590	COG0653	protein targeting
EPB53_RS16600	COG3706	GGDEF domain
EPB53_RS16615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPB53_RS16620	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EPB53_RS16630	COG0745	RESPONSE REGULATOR receiver
EPB53_RS16645	COG3140	Belongs to the UPF0181 family
EPB53_RS16650	COG2873	o-acetylhomoserine
EPB53_RS16655	COG0023	Translation Initiation Factor
EPB53_RS16680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB53_RS16680	COG1042	CoA-binding domain protein
EPB53_RS16680	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB53_RS16685	COG0583	DNA-binding transcription factor activity
EPB53_RS16700	COG2050	protein possibly involved in aromatic compounds catabolism
EPB53_RS16710	COG2824	Alkylphosphonate utilization operon protein PhnA
EPB53_RS16720	COG0861	Integral membrane protein TerC family
EPB53_RS16730	COG3593	DNA synthesis involved in DNA repair
EPB53_RS16745	COG2116	formate transmembrane transporter activity
EPB53_RS16750	COG2353	YceI-like domain
EPB53_RS16755	COG3038	cytochrome b561
EPB53_RS16765	COG0517	IMP dehydrogenase activity
EPB53_RS16780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB53_RS16785	COG1328	CTP reductase activity
EPB53_RS16790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB53_RS16795	COG0673	inositol 2-dehydrogenase activity
EPB53_RS16800	COG2610	gluconate transmembrane transporter activity
EPB53_RS16805	COG1454	alcohol dehydrogenase
EPB53_RS16815	COG0840	transmembrane signaling receptor activity
EPB53_RS16830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB53_RS16835	COG3962	Belongs to the TPP enzyme family
EPB53_RS16840	COG3718	enzyme involved in inositol metabolism
EPB53_RS16850	COG2176	DNA-directed DNA polymerase activity
EPB53_RS16855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPB53_RS16855	COG0517	IMP dehydrogenase activity
EPB53_RS16860	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB53_RS16865	COG0673	inositol 2-dehydrogenase activity
EPB53_RS16875	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB53_RS16880	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB53_RS16885	COG1129	ABC transporter
EPB53_RS16895	COG0488	(ABC) transporter
EPB53_RS16920	COG3181	Tripartite tricarboxylate transporter family receptor
EPB53_RS16925	COG1349	DNA-binding transcription factor activity
EPB53_RS16930	COG2084	Dehydrogenase
EPB53_RS16935	COG3395	kinase activity
EPB53_RS16940	COG0235	Class ii aldolase
EPB53_RS16945	COG3622	Belongs to the hyi family
EPB53_RS16950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB53_RS16955	COG2610	gluconate transmembrane transporter activity
EPB53_RS16965	COG4139	cobalamin transport
EPB53_RS16975	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EPB53_RS16995	COG0577	efflux transmembrane transporter activity
EPB53_RS16995	COG1136	(ABC) transporter
EPB53_RS17000	COG1136	(ABC) transporter
EPB53_RS17000	COG0577	efflux transmembrane transporter activity
EPB53_RS17045	COG2314	TM2 domain
EPB53_RS17070	COG2188	Transcriptional regulator
EPB53_RS17075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB53_RS17080	COG1011	Hydrolase
EPB53_RS17085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EPB53_RS17090	COG0156	8-amino-7-oxononanoate synthase activity
EPB53_RS17095	COG2205	protein histidine kinase activity
EPB53_RS17095	COG0784	Response regulator, receiver
EPB53_RS17100	COG0419	ATPase involved in DNA repair
EPB53_RS17105	COG0420	3'-5' exonuclease activity
EPB53_RS17110	COG1609	Transcriptional regulator
EPB53_RS17115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB53_RS17115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB53_RS17120	COG1105	Belongs to the carbohydrate kinase PfkB family
EPB53_RS17125	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPB53_RS17125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB53_RS17125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB53_RS17145	COG1328	CTP reductase activity
EPB53_RS17165	COG0640	Transcriptional regulator
EPB53_RS17175	COG2211	Major facilitator Superfamily
EPB53_RS17200	COG2211	Major facilitator Superfamily
EPB53_RS17210	COG1609	Transcriptional regulator
EPB53_RS17215	COG2017	converts alpha-aldose to the beta-anomer
EPB53_RS17230	COG1085	galactose-1-phosphate uridylyltransferase
EPB53_RS17235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPB53_RS17255	COG0450	alkyl hydroperoxide reductase
EPB53_RS17330	COG0513	Belongs to the DEAD box helicase family
EPB53_RS17335	COG0814	amino acid
EPB53_RS17340	COG0840	transmembrane signaling receptor activity
EPB53_RS17350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EPB53_RS17365	COG4181	ATPase activity
EPB53_RS17375	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB53_RS17395	COG0546	phosphoglycolate phosphatase activity
EPB53_RS17435	COG0732	type I restriction modification DNA specificity domain
EPB53_RS17465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EPB53_RS17475	COG0509	glycine decarboxylation via glycine cleavage system
EPB53_RS17480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPB53_RS17480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPB53_RS17490	COG1278	Cold shock
EPB53_RS17495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EPB53_RS17500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB53_RS17500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB53_RS17510	COG0303	'Molybdopterin
EPB53_RS17515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB53_RS17520	COG2897	thiosulfate sulfurtransferase activity
EPB53_RS17530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPB53_RS17535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB53_RS17545	COG0840	transmembrane signaling receptor activity
EPB53_RS17560	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB53_RS17565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB53_RS17575	COG3069	C4-dicarboxylate transmembrane transporter activity
EPB53_RS17600	COG0840	transmembrane signaling receptor activity
EPB53_RS17620	COG3604	Transcriptional regulator
EPB53_RS17625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB53_RS17630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB53_RS17660	COG2207	Transcriptional regulator
EPB53_RS17665	COG1979	alcohol dehydrogenase
EPB53_RS17680	COG1803	Methylglyoxal synthase
EPB53_RS17685	COG1335	isochorismatase
EPB53_RS17690	COG0210	DNA helicase
EPB53_RS17715	COG4149	molybdate abc transporter
EPB53_RS17720	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPB53_RS17735	COG1879	ABC-type sugar transport system periplasmic component
EPB53_RS17740	COG2827	Endonuclease containing a URI domain
EPB53_RS17755	COG2926	Belongs to the UPF0265 family
EPB53_RS17770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB53_RS17780	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EPB53_RS17785	COG0247	lactate metabolic process
EPB53_RS17790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB53_RS17795	COG3118	belongs to the thioredoxin family
EPB53_RS17815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family