locus-tag	class	description
GPY05_RS00015	COG1120	ATPase activity
GPY05_RS00020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY05_RS00085	COG3300	MHYT domain
GPY05_RS00085	COG5001	Diguanylate cyclase
GPY05_RS00105	COG1946	Acyl-CoA thioesterase
GPY05_RS00110	COG1522	sequence-specific DNA binding
GPY05_RS00120	COG0616	signal peptide processing
GPY05_RS00125	COG1028	Short-chain dehydrogenase reductase Sdr
GPY05_RS00130	COG2963	transposase activity
GPY05_RS00135	COG2801	Transposase and inactivated derivatives
GPY05_RS00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY05_RS00155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY05_RS00165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY05_RS00170	COG2832	Protein of unknown function (DUF454)
GPY05_RS00180	COG0745	RESPONSE REGULATOR receiver
GPY05_RS00185	COG0583	DNA-binding transcription factor activity
GPY05_RS00190	COG0778	Nitroreductase
GPY05_RS00195	COG1024	Enoyl-CoA hydratase
GPY05_RS00195	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY05_RS00200	COG0183	Belongs to the thiolase family
GPY05_RS00215	COG2067	long-chain fatty acid transport protein
GPY05_RS00220	COG2067	long-chain fatty acid transport protein
GPY05_RS00225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY05_RS00230	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY05_RS00235	COG2982	Protein involved in outer membrane biogenesis
GPY05_RS00240	COG0572	uridine kinase
GPY05_RS00260	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY05_RS00270	COG0516	GMP reductase activity
GPY05_RS00270	COG0517	IMP dehydrogenase activity
GPY05_RS00275	COG3706	GGDEF domain
GPY05_RS00280	COG0314	molybdopterin synthase activity
GPY05_RS00285	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY05_RS00290	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY05_RS00295	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY05_RS00300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY05_RS00305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY05_RS00310	COG2198	Histidine kinase
GPY05_RS00315	COG2204	response regulator
GPY05_RS00320	COG0556	nucleotide-excision repair
GPY05_RS00335	COG3119	arylsulfatase activity
GPY05_RS00380	COG4657	Part of a membrane complex involved in electron transport
GPY05_RS00385	COG2878	Part of a membrane complex involved in electron transport
GPY05_RS00390	COG4656	Part of a membrane complex involved in electron transport
GPY05_RS00395	COG4658	electron transport chain
GPY05_RS00400	COG4659	FMN binding
GPY05_RS00405	COG4660	Part of a membrane complex involved in electron transport
GPY05_RS00410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY05_RS00415	COG0346	lactoylglutathione lyase activity
GPY05_RS00430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY05_RS00435	COG2056	Na+-H+ antiporter family
GPY05_RS00440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY05_RS00445	COG1286	toxin biosynthetic process
GPY05_RS00450	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY05_RS00455	COG0285	dihydrofolate synthase activity
GPY05_RS00465	COG0101	tRNA pseudouridine synthase activity
GPY05_RS00475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY05_RS00480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY05_RS00480	COG1263	PTS System
GPY05_RS00480	COG2190	(PTS) system
GPY05_RS00485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY05_RS00490	COG1940	carbohydrate kinase activity
GPY05_RS00490	COG1846	Transcriptional regulator
GPY05_RS00495	COG4651	solute:proton antiporter activity
GPY05_RS00495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY05_RS00505	COG0250	Participates in transcription elongation, termination and antitermination
GPY05_RS00515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY05_RS00520	COG0563	adenylate kinase activity
GPY05_RS00525	COG0326	Molecular chaperone. Has ATPase activity
GPY05_RS00530	COG3710	Transcriptional regulator
GPY05_RS00545	COG0622	Phosphoesterase
GPY05_RS00550	COG1090	epimerase
GPY05_RS00555	COG0300	oxidoreductase activity
GPY05_RS00565	COG3118	belongs to the thioredoxin family
GPY05_RS00575	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPY05_RS00580	COG0789	Transcriptional regulator
GPY05_RS00610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY05_RS00615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY05_RS00625	COG2190	(PTS) system
GPY05_RS00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY05_RS00635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY05_RS00640	COG1702	phosphate starvation-inducible protein PhoH
GPY05_RS00645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY05_RS00650	COG4535	Mg2 and Co2 transporter CorC
GPY05_RS00655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY05_RS00660	COG2888	peptidyl-tyrosine sulfation
GPY05_RS00665	COG0495	leucyl-tRNA aminoacylation
GPY05_RS00670	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY05_RS00675	COG1466	dna polymerase III delta subunit
GPY05_RS00680	COG0799	negative regulation of ribosome biogenesis
GPY05_RS00685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY05_RS00690	COG0768	penicillin binding
GPY05_RS00695	COG0772	Belongs to the SEDS family
GPY05_RS00700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY05_RS00705	COG1686	Belongs to the peptidase S11 family
GPY05_RS00710	COG2921	Belongs to the UPF0250 family
GPY05_RS00715	COG0321	lipoyl(octanoyl) transferase activity
GPY05_RS00720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY05_RS00730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY05_RS00755	COG1596	polysaccharide export
GPY05_RS00765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY05_RS00795	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPY05_RS00815	COG1045	serine acetyltransferase
GPY05_RS00840	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY05_RS00845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY05_RS00850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY05_RS00855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY05_RS00895	COG2205	protein histidine kinase activity
GPY05_RS00900	COG0745	RESPONSE REGULATOR receiver
GPY05_RS00905	COG0366	Alpha amylase catalytic
GPY05_RS00915	COG1609	Transcriptional regulator
GPY05_RS00920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY05_RS00930	COG2011	ABC-type metal ion transport system permease component
GPY05_RS00935	COG1464	Belongs to the NlpA lipoprotein family
GPY05_RS00940	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY05_RS00950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY05_RS00950	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY05_RS00960	COG3706	GGDEF domain
GPY05_RS00965	COG1611	Belongs to the LOG family
GPY05_RS00970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY05_RS00975	COG2363	Small membrane protein
GPY05_RS00980	COG0583	DNA-binding transcription factor activity
GPY05_RS00985	COG0301	tRNA thio-modification
GPY05_RS00985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY05_RS00995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY05_RS01000	COG1722	exodeoxyribonuclease VII activity
GPY05_RS01005	COG0142	geranyltranstransferase activity
GPY05_RS01010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY05_RS01015	COG0564	pseudouridine synthase activity
GPY05_RS01045	COG1671	Belongs to the UPF0178 family
GPY05_RS01050	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY05_RS01055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY05_RS01060	COG0254	rRNA binding
GPY05_RS01065	COG1720	tRNA m6t6A37 methyltransferase activity
GPY05_RS01070	COG0442	prolyl-tRNA aminoacylation
GPY05_RS01090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY05_RS01090	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY05_RS01100	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY05_RS01105	COG0590	tRNA wobble adenosine to inosine editing
GPY05_RS01110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY05_RS01140	COG0484	heat shock protein binding
GPY05_RS01145	COG0443	Heat shock 70 kDa protein
GPY05_RS01150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY05_RS01155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY05_RS01160	COG0497	DNA recombination
GPY05_RS01165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY05_RS01170	COG2914	Belongs to the UPF0125 (RnfH) family
GPY05_RS01175	COG2867	negative regulation of translational initiation
GPY05_RS01180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY05_RS01195	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY05_RS01200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY05_RS01205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY05_RS01215	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPY05_RS01220	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPY05_RS01225	COG3051	citrate lyase alpha subunit
GPY05_RS01230	COG2301	Belongs to the HpcH HpaI aldolase family
GPY05_RS01235	COG3052	prosthetic group binding
GPY05_RS01240	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPY05_RS01250	COG3630	sodium ion export across plasma membrane
GPY05_RS01255	COG5016	pyruvate
GPY05_RS01255	COG0511	ligase activity, forming carbon-carbon bonds
GPY05_RS01260	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY05_RS01270	COG4565	transcriptional regulatory protein
GPY05_RS01280	COG2200	EAL domain
GPY05_RS01295	COG0583	DNA-binding transcription factor activity
GPY05_RS01300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY05_RS01305	COG1115	amino acid carrier protein
GPY05_RS01310	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY05_RS01315	COG0583	DNA-binding transcription factor activity
GPY05_RS01320	COG1584	GPR1 FUN34 yaaH family protein
GPY05_RS01330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY05_RS01330	COG0519	Catalyzes the synthesis of GMP from XMP
GPY05_RS01335	COG0516	GMP reductase activity
GPY05_RS01335	COG0517	IMP dehydrogenase activity
GPY05_RS01340	COG1570	exodeoxyribonuclease VII activity
GPY05_RS01355	COG1160	GTP binding
GPY05_RS01360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY05_RS01365	COG2976	Protein conserved in bacteria
GPY05_RS01370	COG0124	histidyl-tRNA synthetase
GPY05_RS01375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY05_RS01385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY05_RS01390	COG0105	UTP biosynthetic process
GPY05_RS01395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY05_RS01400	COG2975	iron-sulfur cluster assembly
GPY05_RS01405	COG0633	Ferredoxin
GPY05_RS01425	COG0822	iron-sulfur transferase activity
GPY05_RS01435	COG1959	2 iron, 2 sulfur cluster binding
GPY05_RS01440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY05_RS01445	COG0483	inositol monophosphate 1-phosphatase activity
GPY05_RS01450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY05_RS01455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY05_RS01460	COG1862	Preprotein translocase
GPY05_RS01465	COG0343	queuine tRNA-ribosyltransferase activity
GPY05_RS01470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY05_RS01475	COG0517	IMP dehydrogenase activity
GPY05_RS01490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY05_RS01495	COG0583	DNA-binding transcription factor activity
GPY05_RS01500	COG0450	alkyl hydroperoxide reductase
GPY05_RS01505	COG3142	Participates in the control of copper homeostasis
GPY05_RS01520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY05_RS01525	COG0581	inorganic phosphate transmembrane transporter activity
GPY05_RS01540	COG0248	Ppx GppA phosphatase
GPY05_RS01550	COG5002	protein histidine kinase activity
GPY05_RS01555	COG0745	RESPONSE REGULATOR receiver
GPY05_RS01560	COG2974	May be involved in recombination
GPY05_RS01570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY05_RS01625	COG0542	response to heat
GPY05_RS01635	COG0564	pseudouridine synthase activity
GPY05_RS01640	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY05_RS01645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY05_RS01650	COG1605	Chorismate mutase
GPY05_RS01650	COG0077	Prephenate dehydratase
GPY05_RS01655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY05_RS01665	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY05_RS01670	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY05_RS01680	COG0488	(ABC) transporter
GPY05_RS01690	COG1605	Chorismate mutase
GPY05_RS01690	COG0287	Prephenate dehydrogenase
GPY05_RS01695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY05_RS01700	COG3275	phosphorelay sensor kinase activity
GPY05_RS01705	COG3279	Response regulator of the LytR AlgR family
GPY05_RS01710	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY05_RS01720	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY05_RS01735	COG1966	Carbon starvation protein
GPY05_RS01740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY05_RS01745	COG1047	Peptidyl-prolyl cis-trans
GPY05_RS01750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY05_RS01755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY05_RS01760	COG0196	riboflavin kinase activity
GPY05_RS01765	COG0728	peptidoglycan biosynthetic process
GPY05_RS01770	COG0268	Binds directly to 16S ribosomal RNA
GPY05_RS01780	COG0640	Transcriptional regulator
GPY05_RS01785	COG0583	DNA-binding transcription factor activity
GPY05_RS01790	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY05_RS01795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY05_RS01800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY05_RS01805	COG0730	response to heat
GPY05_RS01810	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPY05_RS01815	COG0494	nUDIX hydrolase
GPY05_RS01820	COG3066	DNA modification
GPY05_RS01825	COG0667	Aldo Keto reductase
GPY05_RS01835	COG2204	response regulator
GPY05_RS01840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY05_RS01845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GPY05_RS01855	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY05_RS01860	COG0513	Belongs to the DEAD box helicase family
GPY05_RS01865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY05_RS01885	COG3153	acetyltransferase
GPY05_RS01915	COG1846	Transcriptional regulator
GPY05_RS01920	COG4785	May be involved in cell division
GPY05_RS01925	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY05_RS01930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY05_RS01935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY05_RS01940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY05_RS01945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY05_RS01950	COG0195	Participates in both transcription termination and antitermination
GPY05_RS01955	COG0779	Required for maturation of 30S ribosomal subunits
GPY05_RS01970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY05_RS01975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY05_RS01980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY05_RS01985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY05_RS01990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY05_RS01995	COG1534	Rna-binding protein
GPY05_RS02000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY05_RS02005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY05_RS02015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY05_RS02020	COG0739	heme binding
GPY05_RS02035	COG0316	Belongs to the HesB IscA family
GPY05_RS02040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY05_RS02050	COG0628	permease
GPY05_RS02055	COG2813	Specifically methylates the guanine in position
GPY05_RS02070	COG0747	negative chemotaxis
GPY05_RS02080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY05_RS02085	COG0444	Belongs to the ABC transporter superfamily
GPY05_RS02090	COG4608	Belongs to the ABC transporter superfamily
GPY05_RS02100	COG2971	BadF BadG BcrA BcrD
GPY05_RS02115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY05_RS02120	COG3842	ATPase activity
GPY05_RS02130	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY05_RS02135	COG0004	ammonium transporteR
GPY05_RS02140	COG0347	Belongs to the P(II) protein family
GPY05_RS02145	COG3112	Uncharacterised protein family (UPF0231)
GPY05_RS02155	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY05_RS02165	COG1643	Atp-dependent helicase
GPY05_RS02170	COG1489	DNA binding
GPY05_RS02175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY05_RS02180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY05_RS02190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY05_RS02195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY05_RS02200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY05_RS02205	COG0842	Transport permease protein
GPY05_RS02210	COG1131	(ABC) transporter
GPY05_RS02215	COG0659	secondary active sulfate transmembrane transporter activity
GPY05_RS02220	COG0288	reversible hydration of carbon dioxide
GPY05_RS02235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY05_RS02240	COG3107	peptidoglycan biosynthetic process
GPY05_RS02245	COG0792	nuclease activity
GPY05_RS02250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY05_RS02255	COG2823	Periplasmic or secreted lipoprotein
GPY05_RS02260	COG2969	positive regulation of protein catabolic process
GPY05_RS02265	COG0625	glutathione transferase activity
GPY05_RS02270	COG2857	Cytochrome c1
GPY05_RS02275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY05_RS02285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY05_RS02290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY05_RS02310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY05_RS02315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY05_RS02320	COG0335	large ribosomal subunit rRNA binding
GPY05_RS02325	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY05_RS02330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY05_RS02335	COG0228	four-way junction DNA binding
GPY05_RS02340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY05_RS02345	COG4137	Cytochrome C assembly protein
GPY05_RS02350	COG4536	flavin adenine dinucleotide binding
GPY05_RS02360	COG2918	glutathione biosynthetic process
GPY05_RS02370	COG1238	metal cluster binding
GPY05_RS02380	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY05_RS02385	COG5016	pyruvate
GPY05_RS02385	COG0511	ligase activity, forming carbon-carbon bonds
GPY05_RS02390	COG3630	sodium ion export across plasma membrane
GPY05_RS02435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPY05_RS02440	COG0527	aspartate kinase activity
GPY05_RS02445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY05_RS02450	COG2137	regulation of response to DNA damage stimulus
GPY05_RS02455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY05_RS02460	COG1546	Belongs to the CinA family
GPY05_RS02465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPY05_RS02470	COG4208	sulfate ABC transporter
GPY05_RS02490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY05_RS02495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY05_RS02500	COG4942	peptidase
GPY05_RS02500	COG1388	LysM domain
GPY05_RS02505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY05_RS02510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY05_RS02515	COG0585	pseudouridine synthase activity
GPY05_RS02520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY05_RS02525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY05_RS02530	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY05_RS02535	COG1968	undecaprenyl-diphosphatase activity
GPY05_RS02540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY05_RS02545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY05_RS02550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY05_RS02560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY05_RS02565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY05_RS02570	COG1610	YqeY-like protein
GPY05_RS02575	COG0358	DNA primase activity
GPY05_RS02580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY05_RS02600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY05_RS02605	COG1349	DNA-binding transcription factor activity
GPY05_RS02610	COG0469	pyruvate kinase activity
GPY05_RS02620	COG0583	DNA-binding transcription factor activity
GPY05_RS02625	COG1279	arginine transmembrane transporter activity
GPY05_RS02630	COG0668	transmembrane transport
GPY05_RS02635	COG0191	fructose-bisphosphate aldolase activity
GPY05_RS02640	COG0126	phosphoglycerate kinase activity
GPY05_RS02645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY05_RS02650	COG4771	TonB-dependent receptor
GPY05_RS02655	COG0583	DNA-binding transcription factor activity
GPY05_RS02660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY05_RS02670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY05_RS02675	COG3091	SprT-like family
GPY05_RS02680	COG2356	endonuclease I
GPY05_RS02685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY05_RS02690	COG0189	ligase activity
GPY05_RS02695	COG1678	Uncharacterized ACR, COG1678
GPY05_RS02700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY05_RS02705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY05_RS02725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY05_RS02730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY05_RS02735	COG0762	integral membrane protein
GPY05_RS02750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY05_RS02755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY05_RS02765	COG2066	Belongs to the glutaminase family
GPY05_RS02770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY05_RS02775	COG1194	a g-specific adenine glycosylase
GPY05_RS02780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY05_RS02785	COG0741	lytic transglycosylase activity
GPY05_RS02840	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY05_RS02845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY05_RS02850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY05_RS02855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY05_RS02860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY05_RS02865	COG2967	ApaG domain
GPY05_RS02870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY05_RS02880	COG3610	response to peptide
GPY05_RS02885	COG2966	Psort location CytoplasmicMembrane, score
GPY05_RS02890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY05_RS02895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY05_RS02900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY05_RS02905	COG0142	geranyltranstransferase activity
GPY05_RS02910	COG0531	amino acid
GPY05_RS02915	COG0039	L-malate dehydrogenase activity
GPY05_RS02920	COG1438	arginine binding
GPY05_RS02935	COG0589	response to stress
GPY05_RS02960	COG4145	pantothenate transmembrane transporter activity
GPY05_RS02980	COG0837	glucose binding
GPY05_RS02980	COG1737	Transcriptional regulator
GPY05_RS02990	COG2235	arginine
GPY05_RS02995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY05_RS03000	COG1151	hydroxylamine reductase activity
GPY05_RS03005	COG0312	modulator of DNA gyrase
GPY05_RS03010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY05_RS03015	COG3164	Protein of unknown function
GPY05_RS03020	COG1530	ribonuclease E activity
GPY05_RS03025	COG0424	maF-like protein
GPY05_RS03030	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY05_RS03035	COG1792	Involved in formation and maintenance of cell shape
GPY05_RS03040	COG1077	Cell shape determining protein MreB Mrl
GPY05_RS03085	COG1459	type II secretion system
GPY05_RS03090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY05_RS03100	COG3409	Peptidoglycan-binding domain 1 protein
GPY05_RS03100	COG3267	Type II secretory pathway component ExeA
GPY05_RS03125	COG2199	diguanylate cyclase activity
GPY05_RS03125	COG2200	EAL domain
GPY05_RS03130	COG0210	DNA helicase
GPY05_RS03210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY05_RS03220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY05_RS03225	COG0527	aspartate kinase activity
GPY05_RS03230	COG0646	methionine synthase
GPY05_RS03230	COG1410	methionine synthase
GPY05_RS03285	COG0175	sulfate reduction
GPY05_RS03295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY05_RS03315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY05_RS03320	COG0735	belongs to the Fur family
GPY05_RS03330	COG0166	Belongs to the GPI family
GPY05_RS03335	COG0432	Pfam Uncharacterised protein family UPF0047
GPY05_RS03340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY05_RS03345	COG0305	Participates in initiation and elongation during chromosome replication
GPY05_RS03355	COG0359	binds to the 23S rRNA
GPY05_RS03360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPY05_RS03365	COG2965	DNA replication, synthesis of RNA primer
GPY05_RS03370	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY05_RS03380	COG2906	2 iron, 2 sulfur cluster binding
GPY05_RS03385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY05_RS03390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY05_RS03395	COG0049	tRNA binding
GPY05_RS03400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPY05_RS03415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY05_RS03420	COG2964	Protein conserved in bacteria
GPY05_RS03425	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY05_RS03435	COG2900	Belongs to the SlyX family
GPY05_RS03440	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY05_RS03445	COG0330	HflC and HflK could
GPY05_RS03450	COG0330	HflC and HflK could
GPY05_RS03455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY05_RS03460	COG1923	regulation of RNA biosynthetic process
GPY05_RS03470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY05_RS03480	COG0802	atpase or kinase
GPY05_RS03485	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY05_RS03530	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY05_RS03535	COG1162	GTPase activity
GPY05_RS03540	COG0688	phosphatidylethanolamine metabolic process
GPY05_RS03545	COG0471	metal ion transport
GPY05_RS03555	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY05_RS03560	COG4942	peptidase
GPY05_RS03575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY05_RS03580	COG2816	NAD+ diphosphatase activity
GPY05_RS03585	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY05_RS03590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY05_RS03595	COG0085	RNA polymerase activity
GPY05_RS03600	COG0222	ribosome binding
GPY05_RS03605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY05_RS03610	COG0081	regulation of translation
GPY05_RS03615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY05_RS03620	COG0250	Participates in transcription elongation, termination and antitermination
GPY05_RS03625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY05_RS03630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY05_RS03655	COG1072	(Pantothenic acid kinase))
GPY05_RS03665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY05_RS03675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY05_RS03715	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY05_RS03725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY05_RS03730	COG3118	belongs to the thioredoxin family
GPY05_RS03735	COG0513	Belongs to the DEAD box helicase family
GPY05_RS03740	COG0248	Ppx GppA phosphatase
GPY05_RS03750	COG2814	Major facilitator Superfamily
GPY05_RS03765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY05_RS03770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY05_RS03775	COG0511	ligase activity, forming carbon-carbon bonds
GPY05_RS03780	COG0439	Biotin carboxylase
GPY05_RS03785	COG2264	protein methyltransferase activity
GPY05_RS03790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY05_RS03795	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY05_RS03815	COG2610	gluconate transmembrane transporter activity
GPY05_RS03820	COG0800	Aldolase
GPY05_RS03835	COG0840	transmembrane signaling receptor activity
GPY05_RS03840	COG1982	Orn Lys Arg decarboxylase major
GPY05_RS03845	COG0531	amino acid
GPY05_RS03850	COG3710	Transcriptional regulator
GPY05_RS03855	COG0789	Transcriptional regulator
GPY05_RS03865	COG0138	bifunctional purine biosynthesis protein purh
GPY05_RS03870	COG0151	Belongs to the GarS family
GPY05_RS03880	COG0776	regulation of translation
GPY05_RS03885	COG1253	flavin adenine dinucleotide binding
GPY05_RS03890	COG3068	Protein conserved in bacteria
GPY05_RS03900	COG1573	uracil-dna glycosylase
GPY05_RS03905	COG0668	transmembrane transport
GPY05_RS03925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY05_RS03960	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY05_RS03960	COG0517	IMP dehydrogenase activity
GPY05_RS03970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY05_RS03990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY05_RS04005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY05_RS04030	COG1086	Polysaccharide biosynthesis protein
GPY05_RS04105	COG1028	Short-chain dehydrogenase reductase Sdr
GPY05_RS04135	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY05_RS04140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY05_RS04155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY05_RS04190	COG1519	Transferase
GPY05_RS04215	COG3642	lipopolysaccharide core region biosynthetic process
GPY05_RS04220	COG0859	PFAM glycosyl transferase family 9
GPY05_RS04225	COG0463	Glycosyl transferase, family 2
GPY05_RS04230	COG0859	PFAM glycosyl transferase family 9
GPY05_RS04235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY05_RS04240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY05_RS04250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY05_RS04255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY05_RS04270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY05_RS04275	COG1309	transcriptional regulator
GPY05_RS04280	COG1560	Kdo2-lipid A biosynthetic process
GPY05_RS04285	COG1560	Kdo2-lipid A biosynthetic process
GPY05_RS04290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY05_RS04295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY05_RS04300	COG1561	YicC-like family, N-terminal region
GPY05_RS04315	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY05_RS04335	COG1120	ATPase activity
GPY05_RS04340	COG4774	siderophore transport
GPY05_RS04355	COG0514	ATP-dependent DNA helicase (RecQ)
GPY05_RS04360	COG2962	Rard protein
GPY05_RS04375	COG1280	lysine exporter protein (LysE YggA)
GPY05_RS04380	COG0210	DNA helicase
GPY05_RS04390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY05_RS04395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY05_RS04410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY05_RS04420	COG0747	negative chemotaxis
GPY05_RS04465	COG1309	transcriptional regulator
GPY05_RS04470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY05_RS04475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY05_RS04480	COG2960	long-chain fatty acid transporting porin activity
GPY05_RS04485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY05_RS04490	COG0583	DNA-binding transcription factor activity
GPY05_RS04565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY05_RS04570	COG1739	Uncharacterized protein family UPF0029
GPY05_RS04575	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY05_RS04575	COG1024	Enoyl-CoA hydratase
GPY05_RS04580	COG0183	Belongs to the thiolase family
GPY05_RS04585	COG0583	DNA-binding transcription factor activity
GPY05_RS04590	COG2814	Major facilitator Superfamily
GPY05_RS04600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY05_RS04605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY05_RS04610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY05_RS04615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY05_RS04620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY05_RS04625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY05_RS04635	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY05_RS04640	COG3312	ion transport
GPY05_RS04645	COG1475	DNA binding
GPY05_RS04650	COG1192	Involved in chromosome partitioning
GPY05_RS04655	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY05_RS04660	COG0445	tRNA wobble uridine modification
GPY05_RS04665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY05_RS04685	COG3778	Protein conserved in bacteria
GPY05_RS04690	COG3299	homolog of phage Mu protein gp47
GPY05_RS04700	COG4384	Bacteriophage Mu Gp45 protein
GPY05_RS04720	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
GPY05_RS04730	COG4386	tail sheath protein
GPY05_RS04750	COG4387	Mu-like prophage protein GP36
GPY05_RS04760	COG4397	Mu-like prophage major head subunit gpT
GPY05_RS04790	COG4383	Mu-like prophage protein gp29
GPY05_RS04795	COG4373	Mu-like prophage FluMu protein gp28
GPY05_RS04805	COG0640	Transcriptional regulator
GPY05_RS04930	COG2842	Transposition protein
GPY05_RS04935	COG2801	Transposase and inactivated derivatives
GPY05_RS04940	COG3423	Transcriptional regulator
GPY05_RS04970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY05_RS04975	COG0706	membrane insertase activity
GPY05_RS04980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY05_RS04985	COG0594	ribonuclease P activity
GPY05_RS04990	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY05_RS04995	COG1126	abc transporter atp-binding protein
GPY05_RS05010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY05_RS05015	COG0592	DNA-directed DNA polymerase activity
GPY05_RS05020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY05_RS05025	COG0187	DNA topoisomerase II activity
GPY05_RS05040	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY05_RS05045	COG3977	Valine--pyruvate aminotransferase
GPY05_RS05050	COG0751	glycine-tRNA ligase activity
GPY05_RS05055	COG0752	glycyl-tRNA synthetase alpha subunit
GPY05_RS05060	COG2119	membrane
GPY05_RS05070	COG0425	Belongs to the sulfur carrier protein TusA family
GPY05_RS05085	COG0604	alcohol dehydrogenase
GPY05_RS05095	COG0129	dihydroxy-acid dehydratase activity
GPY05_RS05100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY05_RS05120	COG0204	Acyl-transferase
GPY05_RS05125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY05_RS05130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY05_RS05140	COG3084	Protein conserved in bacteria
GPY05_RS05150	COG4326	sporulation control protein
GPY05_RS05155	COG1272	protein, Hemolysin III
GPY05_RS05170	COG0569	domain protein
GPY05_RS05175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY05_RS05175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY05_RS05185	COG0242	peptide deformylase activity
GPY05_RS05190	COG1652	LysM domain
GPY05_RS05195	COG0758	DNA mediated transformation
GPY05_RS05200	COG2922	Belongs to the Smg family
GPY05_RS05205	COG0551	DNA topoisomerase type I activity
GPY05_RS05210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY05_RS05215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY05_RS05220	COG0009	L-threonylcarbamoyladenylate synthase
GPY05_RS05230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY05_RS05240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY05_RS05285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY05_RS05290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY05_RS05300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY05_RS05305	COG2104	thiamine diphosphate biosynthetic process
GPY05_RS05310	COG2022	thiamine diphosphate biosynthetic process
GPY05_RS05315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY05_RS05320	COG0006	proline dipeptidase activity
GPY05_RS05320	COG0006	proline dipeptidase activity
GPY05_RS05330	COG2814	Major facilitator Superfamily
GPY05_RS05340	COG1522	sequence-specific DNA binding
GPY05_RS05345	COG5001	Diguanylate cyclase
GPY05_RS05345	COG5002	protein histidine kinase activity
GPY05_RS05350	COG0742	ribosomal rna small subunit methyltransferase
GPY05_RS05360	COG0697	spore germination
GPY05_RS05365	COG0589	response to stress
GPY05_RS05375	COG1528	Iron-storage protein
GPY05_RS05385	COG2081	HI0933 family
GPY05_RS05390	COG0840	transmembrane signaling receptor activity
GPY05_RS05400	COG1322	Protein conserved in bacteria
GPY05_RS05405	COG2226	methyltransferase
GPY05_RS05415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY05_RS05420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY05_RS05425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY05_RS05430	COG0805	protein transport
GPY05_RS05435	COG0534	Mate efflux family protein
GPY05_RS05445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY05_RS05450	COG2937	Belongs to the GPAT DAPAT family
GPY05_RS05455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY05_RS05460	COG3161	chorismate lyase activity
GPY05_RS05470	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY05_RS05480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY05_RS05485	COG0084	hydrolase, TatD family'
GPY05_RS05500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY05_RS05500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY05_RS05505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY05_RS05520	COG3078	GTPase activator activity
GPY05_RS05530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY05_RS05535	COG3071	HemY protein
GPY05_RS05540	COG2959	enzyme of heme biosynthesis
GPY05_RS05545	COG1587	Uroporphyrinogen-III synthase
GPY05_RS05550	COG0181	hydroxymethylbilane synthase activity
GPY05_RS05565	COG1965	Belongs to the frataxin family
GPY05_RS05575	COG0019	diaminopimelate decarboxylase activity
GPY05_RS05580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY05_RS05590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY05_RS05595	COG1011	Hydrolase
GPY05_RS05600	COG2199	diguanylate cyclase activity
GPY05_RS05600	COG2200	EAL domain
GPY05_RS05600	COG3287	FIST C domain
GPY05_RS05615	COG0561	phosphatase activity
GPY05_RS05620	COG2267	carboxylic ester hydrolase activity
GPY05_RS05625	COG1280	lysine exporter protein (LysE YggA)
GPY05_RS05630	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY05_RS05635	COG0783	Belongs to the Dps family
GPY05_RS05665	COG0742	ribosomal rna small subunit methyltransferase
GPY05_RS05670	COG0552	protein localization to endoplasmic reticulum
GPY05_RS05675	COG2884	Cell division ATP-binding protein ftsE
GPY05_RS05680	COG2177	Part of the ABC transporter FtsEX involved in
GPY05_RS05685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY05_RS05690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY05_RS05705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY05_RS05710	COG4206	TonB-dependent receptor
GPY05_RS05760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY05_RS05765	COG5001	Diguanylate cyclase
GPY05_RS05765	COG3300	MHYT domain
GPY05_RS05785	COG0174	glutamine synthetase
GPY05_RS05810	COG1490	D-aminoacyl-tRNA deacylase activity
GPY05_RS05825	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY05_RS05830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY05_RS05835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY05_RS05840	COG3031	protein transport across the cell outer membrane
GPY05_RS05850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY05_RS05855	COG1459	type II secretion system
GPY05_RS05860	COG2165	general secretion pathway protein
GPY05_RS05865	COG2165	general secretion pathway protein
GPY05_RS05870	COG2165	general secretion pathway protein
GPY05_RS05875	COG4795	General secretion pathway protein
GPY05_RS05880	COG3156	type II secretion system protein K
GPY05_RS05885	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY05_RS05890	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY05_RS05900	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY05_RS05910	COG0316	Belongs to the HesB IscA family
GPY05_RS05910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY05_RS05915	COG1040	competence protein
GPY05_RS05920	COG0596	Alpha beta hydrolase
GPY05_RS05930	COG2183	response to ionizing radiation
GPY05_RS05935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY05_RS05950	COG1129	ABC transporter
GPY05_RS05955	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY05_RS05960	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY05_RS05965	COG0745	RESPONSE REGULATOR receiver
GPY05_RS05975	COG2233	PERMEase
GPY05_RS05980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY05_RS05985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY05_RS05990	COG1758	RNA polymerase activity
GPY05_RS05995	COG0194	GDP metabolic process
GPY05_RS06000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY05_RS06005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY05_RS06015	COG3263	regulation of cellular component size
GPY05_RS06025	COG4232	protein-disulfide reductase activity
GPY05_RS06030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY05_RS06035	COG1027	Aspartate ammonia-lyase
GPY05_RS06045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY05_RS06055	COG2205	protein histidine kinase activity
GPY05_RS06060	COG0745	RESPONSE REGULATOR receiver
GPY05_RS06070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY05_RS06075	COG0205	6-phosphofructokinase activity
GPY05_RS06080	COG1494	fructose-1,6-bisphosphatase
GPY05_RS06085	COG3074	FtsZ-dependent cytokinesis
GPY05_RS06090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY05_RS06095	COG0527	aspartate kinase activity
GPY05_RS06095	COG0460	homoserine dehydrogenase
GPY05_RS06100	COG0626	cystathionine gamma-synthase activity
GPY05_RS06105	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPY05_RS06110	COG0281	malic enzyme
GPY05_RS06115	COG0254	rRNA binding
GPY05_RS06120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY05_RS06125	COG1609	Transcriptional regulator
GPY05_RS06135	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY05_RS06140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY05_RS06145	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY05_RS06150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY05_RS06160	COG0149	triose-phosphate isomerase activity
GPY05_RS06185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY05_RS06190	COG0459	protein refolding
GPY05_RS06200	COG1509	lysine 2,3-aminomutase activity
GPY05_RS06205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY05_RS06210	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY05_RS06215	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY05_RS06220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY05_RS06225	COG1053	succinate dehydrogenase
GPY05_RS06230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY05_RS06235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY05_RS06240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY05_RS06245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY05_RS06250	COG1045	serine acetyltransferase
GPY05_RS06260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY05_RS06265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY05_RS06270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY05_RS06275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY05_RS06280	COG0137	argininosuccinate synthase activity
GPY05_RS06285	COG0165	Argininosuccinate lyase
GPY05_RS06295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY05_RS06300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY05_RS06300	COG0678	peroxiredoxin activity
GPY05_RS06310	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY05_RS06340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY05_RS06345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY05_RS06355	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY05_RS06360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY05_RS06365	COG0546	phosphoglycolate phosphatase activity
GPY05_RS06370	COG0180	Tryptophanyl-tRNA synthetase
GPY05_RS06385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY05_RS06395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY05_RS06415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY05_RS06420	COG3954	Phosphoribulokinase
GPY05_RS06430	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY05_RS06440	COG0488	(ABC) transporter
GPY05_RS06445	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY05_RS06460	COG1047	Peptidyl-prolyl cis-trans
GPY05_RS06470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY05_RS06475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY05_RS06480	COG3083	sulfuric ester hydrolase activity
GPY05_RS06485	COG0557	exoribonuclease II activity
GPY05_RS06490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY05_RS06495	COG0051	transcription antitermination factor activity, RNA binding
GPY05_RS06500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY05_RS06505	COG0088	Forms part of the polypeptide exit tunnel
GPY05_RS06510	COG0089	rRNA binding
GPY05_RS06515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY05_RS06520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY05_RS06525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY05_RS06530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY05_RS06535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPY05_RS06540	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY05_RS06550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY05_RS06555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY05_RS06560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY05_RS06565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY05_RS06570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY05_RS06575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY05_RS06580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY05_RS06585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPY05_RS06590	COG1841	ribosomal large subunit assembly
GPY05_RS06595	COG0200	Binds to the 23S rRNA
GPY05_RS06600	COG0201	protein transport
GPY05_RS06610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY05_RS06615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY05_RS06620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY05_RS06625	COG0202	RNA polymerase activity
GPY05_RS06630	COG0203	ribosomal protein L17
GPY05_RS06640	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY05_RS06645	COG3061	Opacity-associated protein A
GPY05_RS06650	COG0697	spore germination
GPY05_RS06655	COG2153	protein acetylation
GPY05_RS06660	COG0513	Belongs to the DEAD box helicase family
GPY05_RS06670	COG0737	Belongs to the 5'-nucleotidase family
GPY05_RS06675	COG1648	precorrin-2 dehydrogenase activity
GPY05_RS06675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY05_RS06680	COG0175	sulfate reduction
GPY05_RS06685	COG2895	sulfate adenylyltransferase (ATP) activity
GPY05_RS06690	COG0529	Catalyzes the synthesis of activated sulfate
GPY05_RS06710	COG1136	(ABC) transporter
GPY05_RS06725	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY05_RS06735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY05_RS06740	COG0729	surface antigen
GPY05_RS06750	COG2105	PFAM AIG2 family protein
GPY05_RS06760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY05_RS06765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY05_RS06770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY05_RS06775	COG0163	prenyltransferase activity
GPY05_RS06780	COG4143	(ABC) transporter
GPY05_RS06785	COG1178	ABC-type Fe3 transport system permease component
GPY05_RS06790	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY05_RS06795	COG3028	Belongs to the UPF0307 family
GPY05_RS06800	COG0312	modulator of DNA gyrase
GPY05_RS06810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY05_RS06820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY05_RS06825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY05_RS06835	COG1137	ATPase activity
GPY05_RS06840	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY05_RS06855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY05_RS06855	COG0517	IMP dehydrogenase activity
GPY05_RS06870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY05_RS06875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY05_RS06880	COG2854	intermembrane phospholipid transfer
GPY05_RS06890	COG5007	Belongs to the BolA IbaG family
GPY05_RS06895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY05_RS06900	COG0204	Acyl-transferase
GPY05_RS06905	COG0251	oxidation-reduction process
GPY05_RS06910	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY05_RS06915	COG0540	Belongs to the ATCase OTCase family
GPY05_RS06920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY05_RS06925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY05_RS06930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY05_RS06935	COG0564	pseudouridine synthase activity
GPY05_RS06940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY05_RS06945	COG4269	membrane
GPY05_RS06955	COG0525	valine-tRNA ligase activity
GPY05_RS06960	COG2927	DNA polymerase III (CHI subunit)
GPY05_RS06965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY05_RS06970	COG0795	lipopolysaccharide-transporting ATPase activity
GPY05_RS06990	COG3437	response regulator, receiver
GPY05_RS07040	COG0066	3-isopropylmalate dehydratase activity
GPY05_RS07045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY05_RS07050	COG0473	3-isopropylmalate dehydrogenase activity
GPY05_RS07055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY05_RS07065	COG0671	phosphoesterase, PA-phosphatase related
GPY05_RS07075	COG0583	DNA-binding transcription factor activity
GPY05_RS07080	COG1022	Amp-dependent synthetase and ligase
GPY05_RS07090	COG0440	acetolactate synthase activity
GPY05_RS07095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY05_RS07100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY05_RS07105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY05_RS07115	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY05_RS07120	COG3079	Belongs to the UPF0149 family
GPY05_RS07125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY05_RS07140	COG0354	folic acid binding
GPY05_RS07145	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY05_RS07160	COG1595	DNA-templated transcription, initiation
GPY05_RS07175	COG3086	response to oxidative stress
GPY05_RS07180	COG0481	GTPase activity
GPY05_RS07185	COG0681	Belongs to the peptidase S26 family
GPY05_RS07190	COG0571	ribonuclease III activity
GPY05_RS07195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY05_RS07200	COG1381	Involved in DNA repair and RecF pathway recombination
GPY05_RS07205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY05_RS07210	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY05_RS07225	COG5001	Diguanylate cyclase
GPY05_RS07230	COG2205	protein histidine kinase activity
GPY05_RS07230	COG3437	response regulator, receiver
GPY05_RS07230	COG3850	Histidine kinase
GPY05_RS07230	COG4999	Histidine kinase
GPY05_RS07235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY05_RS07240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY05_RS07245	COG3956	TIGRFAM MazG family protein
GPY05_RS07250	COG0504	CTP synthase activity
GPY05_RS07255	COG0148	phosphopyruvate hydratase activity
GPY05_RS07260	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY05_RS07265	COG0814	amino acid
GPY05_RS07275	COG0617	tRNA 3'-terminal CCA addition
GPY05_RS07290	COG4991	sh3 domain protein
GPY05_RS07295	COG0306	phosphate transporter
GPY05_RS07300	COG1392	Phosphate transport regulator
GPY05_RS07305	COG3025	triphosphatase activity
GPY05_RS07310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY05_RS07330	COG1538	Outer membrane efflux protein
GPY05_RS07335	COG0494	nUDIX hydrolase
GPY05_RS07340	COG3151	Protein conserved in bacteria
GPY05_RS07350	COG3150	esterase
GPY05_RS07355	COG0187	DNA topoisomerase II activity
GPY05_RS07360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY05_RS07365	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY05_RS07370	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY05_RS07375	COG0237	dephospho-CoA kinase activity
GPY05_RS07385	COG1459	type II secretion system
GPY05_RS07390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY05_RS07400	COG0157	Belongs to the NadC ModD family
GPY05_RS07410	COG0716	FMN binding
GPY05_RS07415	COG4974	Belongs to the 'phage' integrase family
GPY05_RS07420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY05_RS07425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY05_RS07430	COG1227	inorganic diphosphatase activity
GPY05_RS07435	COG0737	Belongs to the 5'-nucleotidase family
GPY05_RS07440	COG2186	Transcriptional regulator
GPY05_RS07445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY05_RS07450	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY05_RS07455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY05_RS07465	COG0275	rRNA processing
GPY05_RS07470	COG3116	cell division
GPY05_RS07475	COG0768	penicillin binding
GPY05_RS07480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY05_RS07485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY05_RS07490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY05_RS07495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY05_RS07500	COG0772	Belongs to the SEDS family
GPY05_RS07505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY05_RS07510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY05_RS07515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY05_RS07520	COG0849	cell division
GPY05_RS07525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY05_RS07530	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY05_RS07540	COG0653	protein targeting
GPY05_RS07545	COG0494	nUDIX hydrolase
GPY05_RS07550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY05_RS07560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY05_RS07565	COG0730	response to heat
GPY05_RS07570	COG0583	DNA-binding transcription factor activity
GPY05_RS07575	COG2860	membrane
GPY05_RS07580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY05_RS07590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY05_RS07600	COG0493	'glutamate synthase
GPY05_RS07605	COG0067	glutamate synthase
GPY05_RS07605	COG0069	glutamate synthase activity
GPY05_RS07605	COG0070	glutamate synthase
GPY05_RS07615	COG0067	glutamate synthase
GPY05_RS07615	COG0069	glutamate synthase activity
GPY05_RS07615	COG0070	glutamate synthase
GPY05_RS07620	COG1242	4 iron, 4 sulfur cluster binding
GPY05_RS07625	COG5001	Diguanylate cyclase
GPY05_RS07625	COG4251	negative regulation of phosphorylation
GPY05_RS07625	COG3706	GGDEF domain
GPY05_RS07625	COG2203	Gaf domain
GPY05_RS07630	COG2198	Histidine kinase
GPY05_RS07630	COG0784	Response regulator, receiver
GPY05_RS07630	COG5002	protein histidine kinase activity
GPY05_RS07635	COG0745	RESPONSE REGULATOR receiver
GPY05_RS07645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY05_RS07670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY05_RS07675	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY05_RS07680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY05_RS07685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY05_RS07695	COG2801	Transposase and inactivated derivatives
GPY05_RS07710	COG1115	amino acid carrier protein
GPY05_RS07725	COG0084	hydrolase, TatD family'
GPY05_RS07730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY05_RS07740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY05_RS07745	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY05_RS07750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY05_RS07755	COG0813	purine-nucleoside phosphorylase activity
GPY05_RS07765	COG0560	Phosphoserine phosphatase
GPY05_RS07775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY05_RS07780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY05_RS07785	COG0583	DNA-binding transcription factor activity
GPY05_RS07795	COG1022	Amp-dependent synthetase and ligase
GPY05_RS07810	COG3250	beta-galactosidase activity
GPY05_RS07815	COG1609	Transcriptional regulator
GPY05_RS07820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY05_RS07835	COG0189	ligase activity
GPY05_RS07835	COG0569	domain protein
GPY05_RS07850	COG2171	N-acyltransferase activity
GPY05_RS07855	COG3141	response to X-ray
GPY05_RS07875	COG1074	ATP-dependent DNA helicase activity
GPY05_RS07880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY05_RS07890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY05_RS07890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY05_RS07900	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY05_RS07905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY05_RS07910	COG2166	iron-sulfur cluster assembly
GPY05_RS07920	COG0693	protein deglycase activity
GPY05_RS07925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY05_RS07940	COG1595	DNA-templated transcription, initiation
GPY05_RS07950	COG2211	Major facilitator Superfamily
GPY05_RS07955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY05_RS07965	COG2813	Specifically methylates the guanine in position
GPY05_RS07970	COG0271	Belongs to the BolA IbaG family
GPY05_RS07975	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY05_RS07980	COG1805	sodium ion transport
GPY05_RS07985	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY05_RS07990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY05_RS07995	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY05_RS08000	COG2871	sodium ion transport
GPY05_RS08005	COG1477	protein flavinylation
GPY05_RS08015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY05_RS08025	COG5001	Diguanylate cyclase
GPY05_RS08025	COG2203	Gaf domain
GPY05_RS08025	COG4251	negative regulation of phosphorylation
GPY05_RS08025	COG3706	GGDEF domain
GPY05_RS08030	COG0733	neurotransmitter:sodium symporter activity
GPY05_RS08035	COG2963	transposase activity
GPY05_RS08040	COG2801	Transposase and inactivated derivatives
GPY05_RS08050	COG0189	ligase activity
GPY05_RS08055	COG0189	ligase activity
GPY05_RS08055	COG4067	protein conserved in archaea
GPY05_RS08060	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY05_RS08065	COG2252	PERMEase
GPY05_RS08070	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY05_RS08085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY05_RS08090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY05_RS08095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY05_RS08100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY05_RS08100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY05_RS08115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPY05_RS08120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY05_RS08130	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY05_RS08140	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY05_RS08145	COG0024	Methionine aminopeptidase
GPY05_RS08150	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY05_RS08155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY05_RS08160	COG0528	UMP kinase activity
GPY05_RS08165	COG0233	cytoplasmic translational termination
GPY05_RS08170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY05_RS08175	COG0575	Belongs to the CDS family
GPY05_RS08180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY05_RS08185	COG0750	zinc metalloprotease
GPY05_RS08195	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY05_RS08200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY05_RS08205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY05_RS08210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY05_RS08215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY05_RS08220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY05_RS08225	COG0587	DNA-directed DNA polymerase activity
GPY05_RS08230	COG0825	malonyl-CoA metabolic process
GPY05_RS08235	COG0037	tRNA processing
GPY05_RS08245	COG0347	Belongs to the P(II) protein family
GPY05_RS08255	COG1388	LysM domain
GPY05_RS08255	COG0741	lytic transglycosylase activity
GPY05_RS08260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY05_RS08265	COG2226	methyltransferase
GPY05_RS08270	COG0328	RNA-DNA hybrid ribonuclease activity
GPY05_RS08275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY05_RS08285	COG1960	acyl-CoA dehydrogenase activity
GPY05_RS08290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY05_RS08295	COG0121	glutamine amidotransferase
GPY05_RS08300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY05_RS08305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY05_RS08310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY05_RS08315	COG1187	pseudouridine synthase activity
GPY05_RS08320	COG2840	Smr protein MutS2
GPY05_RS08350	COG2608	mercury ion transmembrane transporter activity
GPY05_RS08350	COG2217	Heavy metal translocating P-type atpase
GPY05_RS08355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY05_RS08405	COG0784	Response regulator, receiver
GPY05_RS08405	COG0835	chemotaxis
GPY05_RS08410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY05_RS08415	COG1815	bacterial-type flagellum-dependent cell motility
GPY05_RS08420	COG1558	bacterial-type flagellum-dependent cell motility
GPY05_RS08425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY05_RS08430	COG1749	Flagellar hook protein flgE
GPY05_RS08435	COG4787	bacterial-type flagellum-dependent cell motility
GPY05_RS08440	COG4786	Flagellar basal body rod
GPY05_RS08445	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY05_RS08450	COG1706	bacterial-type flagellum-dependent cell motility
GPY05_RS08470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY05_RS08475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY05_RS08560	COG0012	GTP binding
GPY05_RS08565	COG0193	aminoacyl-tRNA hydrolase activity
GPY05_RS08570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY05_RS08575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY05_RS08580	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY05_RS08585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY05_RS08590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY05_RS08595	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY05_RS08600	COG3094	Invasion gene expression up-regulator, SirB
GPY05_RS08605	COG2912	Transglutaminase-like superfamily
GPY05_RS08610	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY05_RS08620	COG0737	Belongs to the 5'-nucleotidase family
GPY05_RS08625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY05_RS08630	COG2233	PERMEase
GPY05_RS08650	COG1393	Belongs to the ArsC family
GPY05_RS08675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY05_RS08685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY05_RS08690	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY05_RS08700	COG1876	peptidase activity
GPY05_RS08705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY05_RS08710	COG1393	Belongs to the ArsC family
GPY05_RS08730	COG2837	iron assimilation
GPY05_RS08735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY05_RS08740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY05_RS08745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY05_RS08750	COG1334	flagellar protein FlaG
GPY05_RS08755	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY05_RS08765	COG1516	flagellar protein fliS
GPY05_RS08770	COG2204	response regulator
GPY05_RS08775	COG4191	Histidine kinase
GPY05_RS08780	COG2204	response regulator
GPY05_RS08800	COG1317	bacterial-type flagellum organization
GPY05_RS08845	COG1987	bacterial-type flagellum assembly
GPY05_RS08865	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY05_RS08870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY05_RS08875	COG2860	membrane
GPY05_RS08880	COG3101	peptidyl-lysine hydroxylation
GPY05_RS08890	COG0431	NADPH-dependent FMN reductase
GPY05_RS08895	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY05_RS08895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY05_RS08900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY05_RS08905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY05_RS08910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY05_RS08920	COG0735	belongs to the Fur family
GPY05_RS08930	COG0583	DNA-binding transcription factor activity
GPY05_RS08955	COG0596	Alpha beta hydrolase
GPY05_RS08960	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY05_RS08965	COG0033	Phosphoglucomutase
GPY05_RS08975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY05_RS08980	COG0372	Belongs to the citrate synthase family
GPY05_RS08985	COG2009	succinate dehydrogenase
GPY05_RS08990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY05_RS08995	COG1053	succinate dehydrogenase
GPY05_RS09010	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY05_RS09015	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY05_RS09025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY05_RS09030	COG1121	(ABC) transporter
GPY05_RS09035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY05_RS09040	COG4977	sequence-specific DNA binding
GPY05_RS09045	COG1918	ferrous iron import across plasma membrane
GPY05_RS09070	COG0018	arginyl-trna synthetase
GPY05_RS09080	COG1025	Belongs to the peptidase M16 family
GPY05_RS09085	COG2062	phosphohistidine phosphatase, SixA
GPY05_RS09100	COG0455	bacterial-type flagellum organization
GPY05_RS09115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY05_RS09120	COG0643	Histidine kinase
GPY05_RS09120	COG2198	Histidine kinase
GPY05_RS09125	COG2201	protein-glutamate methylesterase activity
GPY05_RS09130	COG1192	Involved in chromosome partitioning
GPY05_RS09140	COG0835	chemotaxis
GPY05_RS09150	COG4133	protoheme IX ABC transporter activity
GPY05_RS09155	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY05_RS09160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY05_RS09170	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY05_RS09175	COG1138	Cytochrome C-type biogenesis protein
GPY05_RS09180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY05_RS09185	COG3088	subunit of a heme lyase
GPY05_RS09185	COG4235	cytochrome complex assembly
GPY05_RS09195	COG2853	Lipoprotein
GPY05_RS09215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY05_RS09220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY05_RS09225	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY05_RS09240	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GPY05_RS09260	COG3083	sulfuric ester hydrolase activity
GPY05_RS09270	COG3081	Nucleoid-associated protein
GPY05_RS09280	COG1757	Na H antiporter
GPY05_RS09290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY05_RS09295	COG2095	MarC family integral membrane protein
GPY05_RS09310	COG0659	secondary active sulfate transmembrane transporter activity
GPY05_RS09315	COG1530	ribonuclease E activity
GPY05_RS09330	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY05_RS09335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPY05_RS09340	COG0416	fatty acid biosynthetic process
GPY05_RS09345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY05_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
GPY05_RS09360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY05_RS09365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY05_RS09370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY05_RS09375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY05_RS09380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY05_RS09390	COG0084	hydrolase, TatD family'
GPY05_RS09395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY05_RS09395	COG1263	PTS System
GPY05_RS09410	COG0733	neurotransmitter:sodium symporter activity
GPY05_RS09425	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY05_RS09435	COG1940	carbohydrate kinase activity
GPY05_RS09440	COG0835	chemotaxis
GPY05_RS09440	COG0784	Response regulator, receiver
GPY05_RS09470	COG2226	methyltransferase
GPY05_RS09485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY05_RS09490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY05_RS09500	COG3139	Protein of unknown function (DUF1315)
GPY05_RS09505	COG0252	asparaginase activity
GPY05_RS09510	COG0616	signal peptide processing
GPY05_RS09515	COG1902	pentaerythritol trinitrate reductase activity
GPY05_RS09515	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY05_RS09520	COG0788	formyltetrahydrofolate deformylase activity
GPY05_RS09530	COG1199	ATP-dependent helicase activity
GPY05_RS09535	COG1214	PFAM Peptidase M22, glycoprotease
GPY05_RS09550	COG0596	Alpha beta hydrolase
GPY05_RS09555	COG0318	PFAM AMP-dependent synthetase and ligase
GPY05_RS09560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY05_RS09580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY05_RS09585	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY05_RS09590	COG0436	Aminotransferase
GPY05_RS09600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY05_RS09605	COG0596	Alpha beta hydrolase
GPY05_RS09615	COG1441	menaquinone biosynthetic process
GPY05_RS09625	COG3135	benzoate transporter
GPY05_RS09630	COG1396	sequence-specific DNA binding
GPY05_RS09640	COG0477	Major facilitator Superfamily
GPY05_RS09660	COG3015	lipoprotein NlpE involved in copper resistance
GPY05_RS09665	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY05_RS09670	COG2894	cell division
GPY05_RS09675	COG0850	regulation of cytokinetic process
GPY05_RS09685	COG3100	YcgL domain-containing protein
GPY05_RS09690	COG2951	lytic endotransglycosylase activity
GPY05_RS09700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY05_RS09705	COG3469	chitinase activity
GPY05_RS09705	COG3325	Belongs to the glycosyl hydrolase 18 family
GPY05_RS09715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY05_RS09735	COG0671	phosphoesterase, PA-phosphatase related
GPY05_RS09755	COG4589	Belongs to the CDS family
GPY05_RS09765	COG3300	MHYT domain
GPY05_RS09765	COG5001	Diguanylate cyclase
GPY05_RS09775	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY05_RS09780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY05_RS09785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY05_RS09790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY05_RS09800	COG4191	Histidine kinase
GPY05_RS09810	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY05_RS09820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY05_RS09825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY05_RS09830	COG0776	regulation of translation
GPY05_RS09835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY05_RS09840	COG1555	photosystem II stabilization
GPY05_RS09845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY05_RS09850	COG0539	negative regulation of cytoplasmic translation
GPY05_RS09855	COG0776	regulation of translation
GPY05_RS09860	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY05_RS09865	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY05_RS09870	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY05_RS09885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY05_RS09890	COG1215	transferase activity, transferring glycosyl groups
GPY05_RS09895	COG0438	transferase activity, transferring glycosyl groups
GPY05_RS09930	COG0438	transferase activity, transferring glycosyl groups
GPY05_RS09940	COG2204	response regulator
GPY05_RS09990	COG4239	(ABC) transporter, permease
GPY05_RS09995	COG4166	transmembrane transport
GPY05_RS10000	COG0444	Belongs to the ABC transporter superfamily
GPY05_RS10005	COG4608	Belongs to the ABC transporter superfamily
GPY05_RS10030	COG0583	DNA-binding transcription factor activity
GPY05_RS10040	COG0686	Belongs to the AlaDH PNT family
GPY05_RS10045	COG1522	sequence-specific DNA binding
GPY05_RS10065	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY05_RS10070	COG2186	Transcriptional regulator
GPY05_RS10090	COG0537	adenosine 5'-monophosphoramidase activity
GPY05_RS10120	COG1252	NADH dehydrogenase
GPY05_RS10135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY05_RS10150	COG1136	(ABC) transporter
GPY05_RS10155	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY05_RS10165	COG2333	competence protein COMEC
GPY05_RS10165	COG0658	competence protein
GPY05_RS10170	COG1132	(ABC) transporter
GPY05_RS10175	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY05_RS10185	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY05_RS10200	COG0745	RESPONSE REGULATOR receiver
GPY05_RS10210	COG2719	SpoVR family
GPY05_RS10215	COG2718	Belongs to the UPF0229 family
GPY05_RS10220	COG2766	serine protein kinase
GPY05_RS10225	COG3013	Belongs to the UPF0304 family
GPY05_RS10235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY05_RS10240	COG0840	transmembrane signaling receptor activity
GPY05_RS10250	COG1882	Formate acetyltransferase
GPY05_RS10270	COG4215	(ABC) transporter
GPY05_RS10275	COG4160	amino acid transport
GPY05_RS10280	COG0708	Exodeoxyribonuclease III
GPY05_RS10295	COG3923	Primosomal replication protein n
GPY05_RS10300	COG0730	response to heat
GPY05_RS10305	COG1199	ATP-dependent helicase activity
GPY05_RS10320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY05_RS10325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY05_RS10330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY05_RS10335	COG0215	cysteine-tRNA ligase activity
GPY05_RS10340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY05_RS10345	COG0632	four-way junction helicase activity
GPY05_RS10350	COG2255	four-way junction helicase activity
GPY05_RS10355	COG1271	oxidase subunit
GPY05_RS10360	COG1294	oxidase, subunit
GPY05_RS10365	COG4890	Cyd operon protein YbgT
GPY05_RS10375	COG0824	Thioesterase
GPY05_RS10380	COG0811	peptide transport
GPY05_RS10395	COG0823	Involved in the tonB-independent uptake of proteins
GPY05_RS10400	COG2885	chlorophyll binding
GPY05_RS10410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY05_RS10420	COG0784	Response regulator, receiver
GPY05_RS10420	COG5002	protein histidine kinase activity
GPY05_RS10435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY05_RS10435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY05_RS10435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY05_RS10440	COG2207	Transcriptional regulator
GPY05_RS10450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY05_RS10455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY05_RS10460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY05_RS10470	COG1280	lysine exporter protein (LysE YggA)
GPY05_RS10535	COG0583	DNA-binding transcription factor activity
GPY05_RS10540	COG0641	radical SAM
GPY05_RS10655	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY05_RS10665	COG2771	luxR family
GPY05_RS10665	COG2200	EAL domain
GPY05_RS10680	COG0668	transmembrane transport
GPY05_RS10690	COG1309	transcriptional regulator
GPY05_RS10695	COG1012	belongs to the aldehyde dehydrogenase family
GPY05_RS10715	COG1960	acyl-CoA dehydrogenase activity
GPY05_RS10720	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY05_RS10725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY05_RS10730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY05_RS10735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY05_RS10740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY05_RS10750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY05_RS10760	COG0297	glycogen (starch) synthase activity
GPY05_RS10780	COG3070	regulator of competence-specific genes
GPY05_RS10785	COG1609	Transcriptional regulator
GPY05_RS10790	COG3381	protein complex oligomerization
GPY05_RS10795	COG0745	RESPONSE REGULATOR receiver
GPY05_RS10805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY05_RS10810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY05_RS10815	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY05_RS10820	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY05_RS10825	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY05_RS10830	COG2963	transposase activity
GPY05_RS10835	COG2801	Transposase and inactivated derivatives
GPY05_RS10850	COG1032	radical SAM domain protein
GPY05_RS10855	COG2199	diguanylate cyclase activity
GPY05_RS10855	COG2200	EAL domain
GPY05_RS10855	COG2203	Gaf domain
GPY05_RS10860	COG0612	Peptidase, M16
GPY05_RS10875	COG0583	DNA-binding transcription factor activity
GPY05_RS10880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY05_RS10890	COG2350	Protein conserved in bacteria
GPY05_RS10895	COG1607	acyl-coa hydrolase
GPY05_RS10900	COG2917	probably involved in intracellular septation
GPY05_RS10915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY05_RS10920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY05_RS10930	COG2116	formate transmembrane transporter activity
GPY05_RS10935	COG4459	periplasmic nitrate reductase
GPY05_RS10940	COG3005	denitrification pathway
GPY05_RS10945	COG0243	molybdopterin cofactor binding
GPY05_RS10960	COG1227	inorganic diphosphatase activity
GPY05_RS10975	COG4172	Belongs to the ABC transporter superfamily
GPY05_RS10985	COG4171	peptide transport system, permease
GPY05_RS10990	COG4168	peptide transport system, permease
GPY05_RS11000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY05_RS11005	COG1842	Phage shock protein A
GPY05_RS11020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPY05_RS11025	COG0519	Catalyzes the synthesis of GMP from XMP
GPY05_RS11040	COG0733	neurotransmitter:sodium symporter activity
GPY05_RS11045	COG0564	pseudouridine synthase activity
GPY05_RS11050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY05_RS11055	COG4136	ATPase activity
GPY05_RS11060	COG4135	transport system, permease component
GPY05_RS11065	COG4134	Bacterial extracellular solute-binding protein
GPY05_RS11075	COG3313	Fe-S protein
GPY05_RS11085	COG0842	Transport permease protein
GPY05_RS11090	COG1131	(ABC) transporter
GPY05_RS11095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY05_RS11100	COG0814	amino acid
GPY05_RS11130	COG4934	collagen metabolic process
GPY05_RS11150	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GPY05_RS11195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY05_RS11205	COG0745	RESPONSE REGULATOR receiver
GPY05_RS11215	COG1061	Type III restriction enzyme res subunit
GPY05_RS11220	COG1187	pseudouridine synthase activity
GPY05_RS11240	COG0534	Mate efflux family protein
GPY05_RS11245	COG4181	ATPase activity
GPY05_RS11260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY05_RS11270	COG1748	Saccharopine dehydrogenase
GPY05_RS11275	COG0019	diaminopimelate decarboxylase activity
GPY05_RS11295	COG1538	Outer membrane efflux protein
GPY05_RS11315	COG0583	DNA-binding transcription factor activity
GPY05_RS11325	COG1451	nucleotide metabolic process
GPY05_RS11340	COG3063	Type IV pilus biogenesis stability protein PilW
GPY05_RS11345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY05_RS11365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY05_RS11380	COG3290	protein histidine kinase activity
GPY05_RS11385	COG4565	transcriptional regulatory protein
GPY05_RS11395	COG0835	chemotaxis
GPY05_RS11395	COG0784	Response regulator, receiver
GPY05_RS11435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY05_RS11440	COG0840	transmembrane signaling receptor activity
GPY05_RS11445	COG0471	metal ion transport
GPY05_RS11450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY05_RS11450	COG4191	Histidine kinase
GPY05_RS11480	COG1129	ABC transporter
GPY05_RS11515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY05_RS11525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY05_RS11530	COG0372	Belongs to the citrate synthase family
GPY05_RS11560	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY05_RS11570	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY05_RS11580	COG0625	glutathione transferase activity
GPY05_RS11585	COG3437	response regulator, receiver
GPY05_RS11600	COG3706	GGDEF domain
GPY05_RS11605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY05_RS11615	COG1254	Belongs to the acylphosphatase family
GPY05_RS11620	COG2920	part of a sulfur-relay system
GPY05_RS11625	COG0670	Belongs to the BI1 family
GPY05_RS11630	COG1126	abc transporter atp-binding protein
GPY05_RS11635	COG0765	amino acid transport
GPY05_RS11640	COG4597	amino acid ABC transporter
GPY05_RS11645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY05_RS11655	COG0561	phosphatase activity
GPY05_RS11660	COG0602	queuosine metabolic process
GPY05_RS11665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY05_RS11695	COG3706	GGDEF domain
GPY05_RS11700	COG0443	Heat shock 70 kDa protein
GPY05_RS11705	COG0443	Heat shock 70 kDa protein
GPY05_RS11735	COG1643	Atp-dependent helicase
GPY05_RS11760	COG0443	Heat shock 70 kDa protein
GPY05_RS11765	COG0583	DNA-binding transcription factor activity
GPY05_RS11775	COG2076	Multidrug Resistance protein
GPY05_RS11790	COG0513	Belongs to the DEAD box helicase family
GPY05_RS11795	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY05_RS11805	COG3501	Rhs element vgr protein
GPY05_RS11825	COG1280	lysine exporter protein (LysE YggA)
GPY05_RS11830	COG1115	amino acid carrier protein
GPY05_RS11850	COG2202	Pas domain
GPY05_RS11850	COG2205	protein histidine kinase activity
GPY05_RS11865	COG1012	belongs to the aldehyde dehydrogenase family
GPY05_RS11870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY05_RS11880	COG1177	transmembrane transport
GPY05_RS11885	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY05_RS11890	COG3842	ATPase activity
GPY05_RS11910	COG0037	tRNA processing
GPY05_RS11920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY05_RS11935	COG2217	Heavy metal translocating P-type atpase
GPY05_RS11945	COG2010	Cytochrome c
GPY05_RS11960	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY05_RS11975	COG0784	Response regulator, receiver
GPY05_RS11975	COG5002	protein histidine kinase activity
GPY05_RS11985	COG3120	sequence-specific DNA binding
GPY05_RS11990	COG1067	ATP-dependent peptidase activity
GPY05_RS11995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY05_RS12020	COG0116	Belongs to the methyltransferase superfamily
GPY05_RS12020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY05_RS12030	COG0167	dihydroorotate dehydrogenase activity
GPY05_RS12035	COG2902	Dehydrogenase
GPY05_RS12045	COG0308	aminopeptidase N
GPY05_RS12060	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY05_RS12065	COG1956	GAF domain-containing protein
GPY05_RS12070	COG1132	(ABC) transporter
GPY05_RS12080	COG3008	intermembrane lipid transfer
GPY05_RS12085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY05_RS12085	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY05_RS12090	COG2996	Protein conserved in bacteria
GPY05_RS12105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY05_RS12115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY05_RS12120	COG0004	ammonium transporteR
GPY05_RS12135	COG0437	4 iron, 4 sulfur cluster binding
GPY05_RS12140	COG3383	formate dehydrogenase (NAD+) activity
GPY05_RS12140	COG0243	molybdopterin cofactor binding
GPY05_RS12170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY05_RS12180	COG0488	(ABC) transporter
GPY05_RS12185	COG3852	Histidine kinase
GPY05_RS12200	COG4662	Binding-protein-dependent transport system inner membrane component
GPY05_RS12205	COG3842	ATPase activity
GPY05_RS12210	COG0746	molybdenum cofactor guanylyltransferase activity
GPY05_RS12215	COG0303	'Molybdopterin
GPY05_RS12225	COG1940	carbohydrate kinase activity
GPY05_RS12245	COG0791	NLP P60 protein
GPY05_RS12265	COG0534	Mate efflux family protein
GPY05_RS12275	COG1793	dna ligase
GPY05_RS12290	COG0848	biopolymer transport protein
GPY05_RS12295	COG0811	peptide transport
GPY05_RS12300	COG0811	peptide transport
GPY05_RS12320	COG0395	ABC-type sugar transport system, permease component
GPY05_RS12325	COG3842	ATPase activity
GPY05_RS12335	COG0584	glycerophosphoryl diester phosphodiesterase
GPY05_RS12340	COG2731	YhcH YjgK YiaL family protein
GPY05_RS12345	COG0251	oxidation-reduction process
GPY05_RS12350	COG1609	Transcriptional regulator
GPY05_RS12360	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY05_RS12385	COG0577	efflux transmembrane transporter activity
GPY05_RS12390	COG0577	efflux transmembrane transporter activity
GPY05_RS12390	COG1136	(ABC) transporter
GPY05_RS12395	COG0577	efflux transmembrane transporter activity
GPY05_RS12395	COG1136	(ABC) transporter
GPY05_RS12405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY05_RS12410	COG1780	Probably involved in ribonucleotide reductase function
GPY05_RS12425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY05_RS12430	COG0719	Fe-S assembly protein
GPY05_RS12435	COG0396	ATPase activity
GPY05_RS12440	COG0719	Fe-S assembly protein
GPY05_RS12445	COG0316	Belongs to the HesB IscA family
GPY05_RS12495	COG3064	Membrane
GPY05_RS12505	COG2017	converts alpha-aldose to the beta-anomer
GPY05_RS12510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY05_RS12515	COG1085	galactose-1-phosphate uridylyltransferase
GPY05_RS12595	COG4790	Type iii secretion
GPY05_RS12605	COG3710	Transcriptional regulator
GPY05_RS12635	COG4792	protein secretion
GPY05_RS12640	COG4789	Type iii secretion
GPY05_RS12730	COG1943	Transposase
GPY05_RS12760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY05_RS12780	COG3064	Membrane
GPY05_RS12810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY05_RS12815	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY05_RS12820	COG3768	UPF0283 membrane protein
GPY05_RS12825	COG3106	COG3106 Predicted ATPase
GPY05_RS12840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY05_RS12845	COG0494	nUDIX hydrolase
GPY05_RS12850	COG0814	amino acid
GPY05_RS12855	COG1760	l-serine dehydratase
GPY05_RS12860	COG2963	transposase activity
GPY05_RS12865	COG2801	Transposase and inactivated derivatives
GPY05_RS12870	COG0720	synthase
GPY05_RS12875	COG0840	transmembrane signaling receptor activity
GPY05_RS12880	COG0017	Asparaginyl-tRNA synthetase
GPY05_RS12885	COG0351	phosphomethylpyrimidine kinase
GPY05_RS12890	COG0110	maltose O-acetyltransferase activity
GPY05_RS12895	COG3437	response regulator, receiver
GPY05_RS12895	COG2770	Histidine kinase
GPY05_RS12900	COG1448	Aminotransferase
GPY05_RS12920	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPY05_RS12925	COG2943	transferase activity, transferring hexosyl groups
GPY05_RS12930	COG1609	Transcriptional regulator
GPY05_RS12935	COG3394	polysaccharide catabolic process
GPY05_RS12945	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY05_RS12955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY05_RS12960	COG0726	polysaccharide deacetylase
GPY05_RS12965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY05_RS12970	COG1846	Transcriptional regulator
GPY05_RS13010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY05_RS13015	COG3108	Peptidase M15
GPY05_RS13045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY05_RS13055	COG2814	Major facilitator Superfamily
GPY05_RS13070	COG1278	Cold shock
GPY05_RS13080	COG3088	subunit of a heme lyase
GPY05_RS13080	COG4235	cytochrome complex assembly
GPY05_RS13090	COG1138	Cytochrome C-type biogenesis protein
GPY05_RS13095	COG3301	Polysulphide reductase, NrfD
GPY05_RS13100	COG0437	4 iron, 4 sulfur cluster binding
GPY05_RS13125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY05_RS13130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY05_RS13185	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY05_RS13195	COG2988	succinylglutamate desuccinylase activity
GPY05_RS13210	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY05_RS13215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY05_RS13220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY05_RS13230	COG2925	Exonuclease
GPY05_RS13240	COG1346	cytolysis
GPY05_RS13245	COG0295	cytidine deaminase activity
GPY05_RS13260	COG0500	methyltransferase
GPY05_RS13270	COG0776	regulation of translation
GPY05_RS13275	COG0072	phenylalanine-tRNA ligase activity
GPY05_RS13275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY05_RS13280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY05_RS13285	COG0456	acetyltransferase
GPY05_RS13290	COG3706	GGDEF domain
GPY05_RS13320	COG0322	excinuclease ABC activity
GPY05_RS13325	COG2197	response regulator
GPY05_RS13330	COG0417	DNA replication proofreading
GPY05_RS13335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY05_RS13345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY05_RS13370	COG0010	Belongs to the arginase family
GPY05_RS13375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY05_RS13380	COG2986	histidine ammonia-lyase
GPY05_RS13400	COG0277	FAD linked oxidase domain protein
GPY05_RS13400	COG0247	lactate metabolic process
GPY05_RS13415	COG2885	chlorophyll binding
GPY05_RS13445	COG0281	malic enzyme
GPY05_RS13455	COG2949	membrane
GPY05_RS13460	COG3706	GGDEF domain
GPY05_RS13465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY05_RS13475	COG0492	ferredoxin-NADP+ reductase activity
GPY05_RS13480	COG4988	ABC transporter
GPY05_RS13485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY05_RS13490	COG1187	pseudouridine synthase activity
GPY05_RS13495	COG0009	L-threonylcarbamoyladenylate synthase
GPY05_RS13500	COG0613	PHP domain protein
GPY05_RS13510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY05_RS13515	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY05_RS13520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY05_RS13525	COG0135	phosphoribosylanthranilate isomerase activity
GPY05_RS13525	COG0134	indole-3-glycerol-phosphate synthase activity
GPY05_RS13530	COG0133	tryptophan synthase activity
GPY05_RS13545	COG1435	thymidine kinase activity
GPY05_RS13550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY05_RS13555	COG1801	Protein of unknown function DUF72
GPY05_RS13560	COG4106	trans-aconitate 2-methyltransferase activity
GPY05_RS13565	COG0500	methyltransferase
GPY05_RS13570	COG0189	ligase activity
GPY05_RS13570	COG4067	protein conserved in archaea
GPY05_RS13585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY05_RS13595	COG3852	Histidine kinase
GPY05_RS13610	COG3070	regulator of competence-specific genes
GPY05_RS13630	COG0076	glutamate decarboxylase activity
GPY05_RS13635	COG1737	Transcriptional regulator
GPY05_RS13640	COG1979	alcohol dehydrogenase
GPY05_RS13645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY05_RS13655	COG0542	response to heat
GPY05_RS13660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY05_RS13665	COG1278	Cold shock
GPY05_RS13675	COG1187	pseudouridine synthase activity
GPY05_RS13680	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY05_RS13680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY05_RS13685	COG0107	imidazoleglycerol-phosphate synthase activity
GPY05_RS13690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY05_RS13695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY05_RS13700	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY05_RS13700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY05_RS13705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY05_RS13710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY05_RS13715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY05_RS13720	COG1757	Na H antiporter
GPY05_RS13725	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY05_RS13730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY05_RS13735	COG0482	sulfurtransferase activity
GPY05_RS13740	COG2915	High frequency lysogenization protein hflD homolog
GPY05_RS13745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY05_RS13750	COG2268	Band 7 protein
GPY05_RS13760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY05_RS13775	COG0300	oxidoreductase activity
GPY05_RS13785	COG0501	Belongs to the peptidase M48B family
GPY05_RS13795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY05_RS13800	COG2226	methyltransferase
GPY05_RS13805	COG0156	8-amino-7-oxononanoate synthase activity
GPY05_RS13810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY05_RS13820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY05_RS13825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY05_RS13830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY05_RS13840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY05_RS13845	COG3706	GGDEF domain
GPY05_RS13855	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY05_RS13865	COG4628	conserved protein (DUF2132)
GPY05_RS13870	COG3092	negative regulation of chromosome organization
GPY05_RS13875	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY05_RS13880	COG0857	belongs to the CobB CobQ family
GPY05_RS13880	COG0280	phosphate acetyltransferase
GPY05_RS13885	COG0435	Glutathione S-transferase
GPY05_RS13890	COG4608	Belongs to the ABC transporter superfamily
GPY05_RS13900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY05_RS13905	COG0601	transmembrane transport
GPY05_RS13925	COG2204	response regulator
GPY05_RS13930	COG3300	MHYT domain
GPY05_RS13930	COG5001	Diguanylate cyclase
GPY05_RS13935	COG4191	Histidine kinase
GPY05_RS13940	COG5002	protein histidine kinase activity
GPY05_RS13950	COG2201	protein-glutamate methylesterase activity
GPY05_RS13965	COG0009	L-threonylcarbamoyladenylate synthase
GPY05_RS13980	COG1881	PFAM PEBP family protein
GPY05_RS14005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY05_RS14025	COG2222	sugar isomerase
GPY05_RS14035	COG1349	DNA-binding transcription factor activity
GPY05_RS14040	COG1349	DNA-binding transcription factor activity
GPY05_RS14055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY05_RS14060	COG0640	Transcriptional regulator
GPY05_RS14070	COG0590	tRNA wobble adenosine to inosine editing
GPY05_RS14075	COG2076	Multidrug Resistance protein
GPY05_RS14080	COG2076	Multidrug Resistance protein
GPY05_RS14150	COG0561	phosphatase activity
GPY05_RS14155	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPY05_RS14160	COG3623	hexulose-6-phosphate isomerase
GPY05_RS14175	COG2149	membrane
GPY05_RS14185	COG1263	PTS System
GPY05_RS14185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY05_RS14200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY05_RS14210	COG1629	transport
GPY05_RS14210	COG4771	TonB-dependent receptor
GPY05_RS14220	COG4604	ABC transporter, ATP-binding protein
GPY05_RS14225	COG4605	iron ion homeostasis
GPY05_RS14230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY05_RS14250	COG3291	Pkd domain containing protein
GPY05_RS14250	COG4412	M6 family metalloprotease domain protein
GPY05_RS14255	COG0840	transmembrane signaling receptor activity
GPY05_RS14265	COG3240	lipase activity
GPY05_RS14270	COG3706	GGDEF domain
GPY05_RS14280	COG2814	Major facilitator Superfamily
GPY05_RS14285	COG1757	Na H antiporter
GPY05_RS14295	COG4191	Histidine kinase
GPY05_RS14295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY05_RS14300	COG0784	Response regulator, receiver
GPY05_RS14300	COG3437	response regulator, receiver
GPY05_RS14305	COG0840	transmembrane signaling receptor activity
GPY05_RS14310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY05_RS14315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY05_RS14320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY05_RS14325	COG0513	Belongs to the DEAD box helicase family
GPY05_RS14460	COG4695	Portal protein
GPY05_RS14535	COG0658	competence protein
GPY05_RS14535	COG2333	competence protein COMEC
GPY05_RS14545	COG4974	Belongs to the 'phage' integrase family
GPY05_RS14550	COG0516	GMP reductase activity
GPY05_RS14560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY05_RS14570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY05_RS14575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY05_RS14575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY05_RS14600	COG3036	rescue of stalled ribosome
GPY05_RS14605	COG1278	Cold shock
GPY05_RS14615	COG3604	Transcriptional regulator
GPY05_RS14630	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY05_RS14635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY05_RS14650	COG0840	transmembrane signaling receptor activity
GPY05_RS14655	COG0714	Associated with various cellular activities
GPY05_RS14675	COG2304	oxidoreductase activity
GPY05_RS14690	COG1278	Cold shock
GPY05_RS14695	COG5002	protein histidine kinase activity
GPY05_RS14695	COG5001	Diguanylate cyclase
GPY05_RS14705	COG3530	Putative quorum-sensing-regulated virulence factor
GPY05_RS14715	COG3033	Beta-eliminating lyase
GPY05_RS14725	COG0488	(ABC) transporter
GPY05_RS14730	COG1017	nitric oxide dioxygenase activity
GPY05_RS14730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY05_RS14735	COG1609	Transcriptional regulator
GPY05_RS14740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY05_RS14755	COG0242	peptide deformylase activity
GPY05_RS14805	COG2271	Major facilitator Superfamily
GPY05_RS14810	COG0584	glycerophosphoryl diester phosphodiesterase
GPY05_RS14820	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY05_RS14835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY05_RS14840	COG1879	ABC-type sugar transport system periplasmic component
GPY05_RS14845	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY05_RS14850	COG1129	ABC transporter
GPY05_RS14855	COG1869	D-ribose catabolic process
GPY05_RS14975	COG0564	pseudouridine synthase activity
GPY05_RS14985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY05_RS14990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY05_RS14995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY05_RS15000	COG0673	inositol 2-dehydrogenase activity
GPY05_RS15005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY05_RS15035	COG1342	Belongs to the UPF0251 family
GPY05_RS15050	COG1301	dicarboxylic acid transport
GPY05_RS15055	COG0700	Nucleoside recognition
GPY05_RS15060	COG3366	ferrous iron transmembrane transporter activity
GPY05_RS15065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY05_RS15070	COG4565	transcriptional regulatory protein
GPY05_RS15080	COG0471	metal ion transport
GPY05_RS15095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY05_RS15100	COG2259	Doxx family
GPY05_RS15125	COG0363	glucosamine-6-phosphate deaminase activity
GPY05_RS15140	COG4580	involved in the transport of maltose and maltodextrins
GPY05_RS15150	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY05_RS15160	COG0840	transmembrane signaling receptor activity
GPY05_RS15170	COG0840	transmembrane signaling receptor activity
GPY05_RS15185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY05_RS15215	COG1280	lysine exporter protein (LysE YggA)
GPY05_RS15245	COG0513	Belongs to the DEAD box helicase family
GPY05_RS15255	COG2186	Transcriptional regulator
GPY05_RS15265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY05_RS15275	COG0246	Mannitol dehydrogenase
GPY05_RS15280	COG1904	glucuronate isomerase
GPY05_RS15285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY05_RS15290	COG0800	Aldolase
GPY05_RS15300	COG0583	DNA-binding transcription factor activity
GPY05_RS15310	COG1902	pentaerythritol trinitrate reductase activity
GPY05_RS15320	COG1132	(ABC) transporter
GPY05_RS15330	COG1280	lysine exporter protein (LysE YggA)
GPY05_RS15335	COG2207	Transcriptional regulator
GPY05_RS15355	COG1846	Transcriptional regulator
GPY05_RS15360	COG1764	response to oxidative stress
GPY05_RS15365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY05_RS15370	COG0697	spore germination
GPY05_RS15375	COG0678	peroxiredoxin activity
GPY05_RS15375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY05_RS15390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY05_RS15395	COG0583	DNA-binding transcription factor activity
GPY05_RS15400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY05_RS15405	COG0569	domain protein
GPY05_RS15410	COG0745	RESPONSE REGULATOR receiver
GPY05_RS15415	COG2205	protein histidine kinase activity
GPY05_RS15430	COG2814	Major facilitator Superfamily
GPY05_RS15435	COG0583	DNA-binding transcription factor activity
GPY05_RS15445	COG0739	heme binding
GPY05_RS15455	COG0659	secondary active sulfate transmembrane transporter activity
GPY05_RS15475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY05_RS15480	COG0581	inorganic phosphate transmembrane transporter activity
GPY05_RS15485	COG0573	inorganic phosphate transmembrane transporter activity
GPY05_RS15490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY05_RS15495	COG0840	transmembrane signaling receptor activity
GPY05_RS15505	COG0513	Belongs to the DEAD box helicase family
GPY05_RS15515	COG1376	ErfK ybiS ycfS ynhG family protein
GPY05_RS15515	COG1388	LysM domain
GPY05_RS15520	COG0415	Belongs to the DNA photolyase family
GPY05_RS15525	COG0789	Transcriptional regulator
GPY05_RS15530	COG3272	Protein of unknown function (DUF1722)
GPY05_RS15535	COG0813	purine-nucleoside phosphorylase activity
GPY05_RS15550	COG3706	GGDEF domain
GPY05_RS15560	COG1566	PFAM secretion protein HlyD family protein
GPY05_RS15575	COG3655	Transcriptional regulator
GPY05_RS15590	COG0786	glutamate:sodium symporter activity
GPY05_RS15605	COG1999	signal sequence binding
GPY05_RS15610	COG2847	Copper chaperone PCu(A)C
GPY05_RS15615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY05_RS15625	COG0671	phosphoesterase, PA-phosphatase related
GPY05_RS15655	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY05_RS15660	COG0471	metal ion transport
GPY05_RS15695	COG3501	Rhs element vgr protein
GPY05_RS15710	COG1640	4-alpha-glucanotransferase
GPY05_RS15715	COG0058	SHG alpha-glucan phosphorylase activity
GPY05_RS15735	COG2084	Dehydrogenase
GPY05_RS15740	COG0217	transcriptional regulatory protein
GPY05_RS15775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY05_RS15780	COG1444	tRNA N-acetyltransferase activity
GPY05_RS15790	COG1022	Amp-dependent synthetase and ligase
GPY05_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
GPY05_RS15810	COG0745	RESPONSE REGULATOR receiver
GPY05_RS15820	COG2194	sulfuric ester hydrolase activity
GPY05_RS15830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY05_RS15835	COG0601	transmembrane transport
GPY05_RS15860	COG0835	chemotaxis
GPY05_RS15865	COG0835	chemotaxis
GPY05_RS15870	COG0840	transmembrane signaling receptor activity
GPY05_RS15880	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPY05_RS15900	COG3706	GGDEF domain
GPY05_RS15900	COG0745	RESPONSE REGULATOR receiver
GPY05_RS15930	COG0259	pyridoxamine-phosphate oxidase activity
GPY05_RS15940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY05_RS15965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY05_RS16015	COG2197	response regulator
GPY05_RS16025	COG1982	Orn Lys Arg decarboxylase major
GPY05_RS16030	COG0531	amino acid
GPY05_RS16035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY05_RS16045	COG1901	pseudouridine methyltransferase
GPY05_RS16060	COG4221	oxidoreductase activity
GPY05_RS16075	COG2910	NAD(P)H-binding
GPY05_RS16095	COG0655	NAD(P)H dehydrogenase (quinone) activity
GPY05_RS16100	COG0583	DNA-binding transcription factor activity
GPY05_RS16115	COG0697	spore germination
GPY05_RS16145	COG0673	inositol 2-dehydrogenase activity
GPY05_RS16150	COG3722	fumarate hydratase activity
GPY05_RS16155	COG0246	Mannitol dehydrogenase
GPY05_RS16165	COG0739	heme binding
GPY05_RS16175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY05_RS16180	COG4597	amino acid ABC transporter
GPY05_RS16185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY05_RS16195	COG1126	abc transporter atp-binding protein
GPY05_RS16200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY05_RS16205	COG0534	Mate efflux family protein
GPY05_RS16210	COG0840	transmembrane signaling receptor activity
GPY05_RS16215	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY05_RS16220	COG1366	Belongs to the anti-sigma-factor antagonist family
GPY05_RS16230	COG2172	sigma factor antagonist activity
GPY05_RS16255	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY05_RS16265	COG1304	FMN binding
GPY05_RS16270	COG1620	l-lactate permease
GPY05_RS16275	COG0583	DNA-binding transcription factor activity
GPY05_RS16280	COG4172	Belongs to the ABC transporter superfamily
GPY05_RS16290	COG1067	ATP-dependent peptidase activity
GPY05_RS16300	COG2211	Major facilitator Superfamily
GPY05_RS16310	COG3123	guanosine phosphorylase activity
GPY05_RS16315	COG1741	Belongs to the pirin family
GPY05_RS16325	COG5001	Diguanylate cyclase
GPY05_RS16330	COG0583	DNA-binding transcription factor activity
GPY05_RS16375	COG1846	Transcriptional regulator
GPY05_RS16380	COG0784	Response regulator, receiver
GPY05_RS16380	COG0835	chemotaxis
GPY05_RS16385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY05_RS16400	COG0583	DNA-binding transcription factor activity
GPY05_RS16410	COG2197	response regulator
GPY05_RS16415	COG0393	Putative heavy-metal-binding
GPY05_RS16430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY05_RS16435	COG3842	ATPase activity
GPY05_RS16445	COG1175	transmembrane transport
GPY05_RS16450	COG3833	ABC-type maltose transport systems, permease component
GPY05_RS16465	COG0737	Belongs to the 5'-nucleotidase family
GPY05_RS16475	COG1349	DNA-binding transcription factor activity
GPY05_RS16505	COG1278	Cold shock
GPY05_RS16510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY05_RS16520	COG0488	(ABC) transporter
GPY05_RS16530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY05_RS16535	COG0418	dihydroorotase activity
GPY05_RS16540	COG0633	Ferredoxin
GPY05_RS16540	COG3217	Mosc domain protein beta barrel domain protein
GPY05_RS16540	COG0633	Ferredoxin
GPY05_RS16540	COG3217	Mosc domain protein beta barrel domain protein
GPY05_RS16580	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY05_RS16585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY05_RS16590	COG4558	Periplasmic binding protein
GPY05_RS16595	COG0848	biopolymer transport protein
GPY05_RS16600	COG0811	peptide transport
GPY05_RS16605	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY05_RS16615	COG3721	Heme iron utilization protein
GPY05_RS16620	COG0748	coenzyme F420 binding
GPY05_RS16630	COG1858	cytochrome C peroxidase
GPY05_RS16635	COG3835	regulator
GPY05_RS16640	COG2610	gluconate transmembrane transporter activity
GPY05_RS16645	COG1929	Belongs to the glycerate kinase type-1 family
GPY05_RS16665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY05_RS16670	COG0363	glucosamine-6-phosphate deaminase activity
GPY05_RS16675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY05_RS16680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY05_RS16695	COG5001	Diguanylate cyclase
GPY05_RS16695	COG4251	negative regulation of phosphorylation
GPY05_RS16695	COG2203	Gaf domain
GPY05_RS16695	COG3706	GGDEF domain
GPY05_RS16710	COG0346	lactoylglutathione lyase activity
GPY05_RS16720	COG2873	o-acetylhomoserine
GPY05_RS16725	COG0156	8-amino-7-oxononanoate synthase activity
GPY05_RS16730	COG1063	alcohol dehydrogenase
GPY05_RS16740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY05_RS16750	COG0641	radical SAM
GPY05_RS16755	COG0583	DNA-binding transcription factor activity
GPY05_RS16760	COG1686	Belongs to the peptidase S11 family
GPY05_RS16770	COG3047	cAMP biosynthetic process
GPY05_RS16775	COG3227	Zinc metalloprotease (Elastase)
GPY05_RS16790	COG2267	carboxylic ester hydrolase activity
GPY05_RS16795	COG2067	long-chain fatty acid transport protein
GPY05_RS16805	COG4989	oxidoreductase activity
GPY05_RS16815	COG1136	(ABC) transporter
GPY05_RS16835	COG3275	phosphorelay sensor kinase activity
GPY05_RS16840	COG3279	Response regulator of the LytR AlgR family
GPY05_RS16850	COG3706	GGDEF domain
GPY05_RS16855	COG0531	amino acid
GPY05_RS16875	COG5001	Diguanylate cyclase
GPY05_RS16890	COG1566	PFAM secretion protein HlyD family protein
GPY05_RS16900	COG1765	OsmC-like protein
GPY05_RS16905	COG1253	flavin adenine dinucleotide binding
GPY05_RS16910	COG2171	N-acyltransferase activity
GPY05_RS16920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY05_RS16935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY05_RS16940	COG3186	Phenylalanine-4-hydroxylase
GPY05_RS16945	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY05_RS16955	COG0534	Mate efflux family protein
GPY05_RS16995	COG1166	arginine decarboxylase activity
GPY05_RS17015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY05_RS17020	COG0800	Aldolase
GPY05_RS17025	COG1085	galactose-1-phosphate uridylyltransferase
GPY05_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
GPY05_RS17055	COG3119	arylsulfatase activity
GPY05_RS17060	COG3119	arylsulfatase activity
GPY05_RS17080	COG0601	transmembrane transport
GPY05_RS17085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY05_RS17100	COG1414	Transcriptional regulator
GPY05_RS17105	COG1686	Belongs to the peptidase S11 family
GPY05_RS17120	COG3338	carbonate dehydratase activity
GPY05_RS17125	COG2755	lipolytic protein G-D-S-L family
GPY05_RS17130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY05_RS17130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY05_RS17140	COG0509	glycine decarboxylation via glycine cleavage system
GPY05_RS17145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY05_RS17155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY05_RS17160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY05_RS17170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY05_RS17175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPY05_RS17275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY05_RS17280	COG0456	acetyltransferase
GPY05_RS17285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY05_RS17440	COG0456	acetyltransferase
GPY05_RS17465	COG0456	acetyltransferase
GPY05_RS17570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY05_RS17865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY05_RS17885	COG0384	phenazine biosynthesis protein PhzF
GPY05_RS17940	COG2814	Major facilitator Superfamily
GPY05_RS17955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY05_RS17965	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GPY05_RS17975	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GPY05_RS18000	COG4977	sequence-specific DNA binding
GPY05_RS18000	COG1917	Cupin 2, conserved barrel domain protein
GPY05_RS18010	COG1328	CTP reductase activity
GPY05_RS18015	COG0602	queuosine metabolic process
GPY05_RS18025	COG0189	ligase activity
GPY05_RS18025	COG4067	protein conserved in archaea
GPY05_RS18030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY05_RS18035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY05_RS18035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY05_RS18035	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY05_RS18040	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY05_RS18045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY05_RS18045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY05_RS18065	COG2205	protein histidine kinase activity
GPY05_RS18065	COG0784	Response regulator, receiver
GPY05_RS18070	COG0156	8-amino-7-oxononanoate synthase activity
GPY05_RS18080	COG0038	chloride channel
GPY05_RS18085	COG0523	cobalamin synthesis protein
GPY05_RS18095	COG4409	exo-alpha-(2->6)-sialidase activity
GPY05_RS18100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY05_RS18105	COG1940	carbohydrate kinase activity
GPY05_RS18110	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPY05_RS18120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY05_RS18125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY05_RS18135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY05_RS18140	COG1737	Transcriptional regulator
GPY05_RS18145	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY05_RS18150	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY05_RS18175	COG5001	Diguanylate cyclase
GPY05_RS18175	COG3300	MHYT domain
GPY05_RS18185	COG3038	cytochrome b561
GPY05_RS18195	COG2116	formate transmembrane transporter activity
GPY05_RS18200	COG0583	DNA-binding transcription factor activity
GPY05_RS18210	COG3593	DNA synthesis involved in DNA repair
GPY05_RS18215	COG0737	Belongs to the 5'-nucleotidase family
GPY05_RS18230	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY05_RS18265	COG3706	GGDEF domain
GPY05_RS18300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY05_RS18305	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY05_RS18410	COG0023	Translation Initiation Factor
GPY05_RS18420	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY05_RS18430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY05_RS18430	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY05_RS18430	COG1042	CoA-binding domain protein
GPY05_RS18435	COG0583	DNA-binding transcription factor activity
GPY05_RS18440	COG4771	TonB-dependent receptor
GPY05_RS18455	COG2050	protein possibly involved in aromatic compounds catabolism
GPY05_RS18475	COG0625	glutathione transferase activity
GPY05_RS18490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY05_RS18500	COG4172	Belongs to the ABC transporter superfamily
GPY05_RS18510	COG4174	ABC transporter (Permease)
GPY05_RS18515	COG4166	transmembrane transport
GPY05_RS18560	COG3842	ATPase activity
GPY05_RS18565	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY05_RS18570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY05_RS18580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY05_RS18585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY05_RS18590	COG1011	Hydrolase
GPY05_RS18600	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY05_RS18605	COG1454	alcohol dehydrogenase
GPY05_RS18610	COG1970	mechanosensitive ion channel activity
GPY05_RS18615	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY05_RS18620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY05_RS18620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY05_RS18625	COG0302	gtp cyclohydrolase
GPY05_RS18635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY05_RS18655	COG2390	Transcriptional regulator
GPY05_RS18660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY05_RS18665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY05_RS18690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY05_RS18725	COG0583	DNA-binding transcription factor activity
GPY05_RS18760	COG0640	Transcriptional regulator
GPY05_RS18780	COG1566	PFAM secretion protein HlyD family protein
GPY05_RS18835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY05_RS18850	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY05_RS18860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY05_RS18865	COG0840	transmembrane signaling receptor activity
GPY05_RS18870	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY05_RS18885	COG3850	Histidine kinase
GPY05_RS18890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY05_RS18900	COG0243	molybdopterin cofactor binding
GPY05_RS18910	COG3005	denitrification pathway
GPY05_RS18920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY05_RS18925	COG2197	response regulator
GPY05_RS18940	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY05_RS18950	COG3842	ATPase activity
GPY05_RS19025	COG0583	DNA-binding transcription factor activity
GPY05_RS19035	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY05_RS19045	COG0183	Belongs to the thiolase family
GPY05_RS19065	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY05_RS19070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY05_RS19085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY05_RS19100	COG3706	GGDEF domain
GPY05_RS19115	COG1979	alcohol dehydrogenase
GPY05_RS19130	COG4191	Histidine kinase
GPY05_RS19135	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY05_RS19140	COG2271	Major facilitator Superfamily
GPY05_RS19145	COG0469	pyruvate kinase activity
GPY05_RS19150	COG0784	Response regulator, receiver
GPY05_RS19150	COG2198	Histidine kinase
GPY05_RS19150	COG2205	protein histidine kinase activity
GPY05_RS19155	COG1879	ABC-type sugar transport system periplasmic component
GPY05_RS19160	COG1803	Methylglyoxal synthase
GPY05_RS19165	COG1335	isochorismatase
GPY05_RS19175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY05_RS19195	COG0210	DNA helicase
GPY05_RS19220	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY05_RS19225	COG4149	molybdate abc transporter
GPY05_RS19230	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY05_RS19235	COG1492	cobalamin metabolic process
GPY05_RS19255	COG5002	protein histidine kinase activity
GPY05_RS19255	COG0784	Response regulator, receiver
GPY05_RS19260	COG1879	ABC-type sugar transport system periplasmic component
GPY05_RS19270	COG2827	Endonuclease containing a URI domain
GPY05_RS19275	COG3132	Protein of unknown function, DUF480
GPY05_RS19295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY05_RS19300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY05_RS19305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY05_RS19310	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY05_RS19315	COG0247	lactate metabolic process
GPY05_RS19325	COG1215	transferase activity, transferring glycosyl groups
GPY05_RS19335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY05_RS19340	COG3118	belongs to the thioredoxin family
GPY05_RS19370	COG0243	molybdopterin cofactor binding
GPY05_RS19375	COG0583	DNA-binding transcription factor activity
GPY05_RS19380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY05_RS19385	COG4160	amino acid transport
GPY05_RS19390	COG4215	(ABC) transporter
GPY05_RS19395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY05_RS19400	COG1126	abc transporter atp-binding protein
GPY05_RS19410	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY05_RS19420	COG0494	nUDIX hydrolase
GPY05_RS19425	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY05_RS19440	COG0513	Belongs to the DEAD box helicase family
GPY05_RS19445	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY05_RS19455	COG0814	amino acid
GPY05_RS19460	COG0840	transmembrane signaling receptor activity
GPY05_RS19465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY05_RS19470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY05_RS19475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY05_RS19495	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY05_RS19500	COG4181	ATPase activity
GPY05_RS19510	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY05_RS19515	COG1716	ATPase activity
GPY05_RS19515	COG5001	Diguanylate cyclase
GPY05_RS19525	COG0484	heat shock protein binding
GPY05_RS19545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY05_RS19560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY05_RS19565	COG1368	sulfuric ester hydrolase activity
GPY05_RS19575	COG0513	Belongs to the DEAD box helicase family
GPY05_RS19580	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY05_RS19590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY05_RS19600	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY05_RS19605	COG3397	chitin binding