locus-tag	class	description
GPY12_RS00015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY12_RS00020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY12_RS00020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY12_RS00035	COG0084	hydrolase, TatD family'
GPY12_RS00040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY12_RS00050	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY12_RS00060	COG3161	chorismate lyase activity
GPY12_RS00065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY12_RS00070	COG2937	Belongs to the GPAT DAPAT family
GPY12_RS00075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY12_RS00085	COG0534	Mate efflux family protein
GPY12_RS00090	COG0805	protein transport
GPY12_RS00095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY12_RS00100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY12_RS00105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY12_RS00115	COG2226	methyltransferase
GPY12_RS00120	COG1322	Protein conserved in bacteria
GPY12_RS00130	COG0840	transmembrane signaling receptor activity
GPY12_RS00135	COG2081	HI0933 family
GPY12_RS00145	COG1528	Iron-storage protein
GPY12_RS00155	COG0589	response to stress
GPY12_RS00160	COG0697	spore germination
GPY12_RS00170	COG0742	ribosomal rna small subunit methyltransferase
GPY12_RS00175	COG5002	protein histidine kinase activity
GPY12_RS00175	COG5001	Diguanylate cyclase
GPY12_RS00180	COG1522	sequence-specific DNA binding
GPY12_RS00190	COG2814	Major facilitator Superfamily
GPY12_RS00200	COG0006	proline dipeptidase activity
GPY12_RS00200	COG0006	proline dipeptidase activity
GPY12_RS00205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY12_RS00210	COG2022	thiamine diphosphate biosynthetic process
GPY12_RS00215	COG2104	thiamine diphosphate biosynthetic process
GPY12_RS00220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY12_RS00230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY12_RS00235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY12_RS00275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY12_RS00285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY12_RS00295	COG0009	L-threonylcarbamoyladenylate synthase
GPY12_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY12_RS00305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY12_RS00310	COG0551	DNA topoisomerase type I activity
GPY12_RS00315	COG2922	Belongs to the Smg family
GPY12_RS00320	COG0758	DNA mediated transformation
GPY12_RS00325	COG1652	LysM domain
GPY12_RS00330	COG0242	peptide deformylase activity
GPY12_RS00340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY12_RS00340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY12_RS00345	COG0569	domain protein
GPY12_RS00350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY12_RS00360	COG1272	protein, Hemolysin III
GPY12_RS00365	COG4326	sporulation control protein
GPY12_RS00375	COG3084	Protein conserved in bacteria
GPY12_RS00385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY12_RS00390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY12_RS00395	COG0204	Acyl-transferase
GPY12_RS00400	COG0606	chelatase, subunit chli
GPY12_RS00415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY12_RS00420	COG0129	dihydroxy-acid dehydratase activity
GPY12_RS00430	COG0604	alcohol dehydrogenase
GPY12_RS00455	COG2119	membrane
GPY12_RS00460	COG0752	glycyl-tRNA synthetase alpha subunit
GPY12_RS00465	COG0751	glycine-tRNA ligase activity
GPY12_RS00470	COG3977	Valine--pyruvate aminotransferase
GPY12_RS00475	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY12_RS00485	COG0187	DNA topoisomerase II activity
GPY12_RS00490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY12_RS00495	COG0592	DNA-directed DNA polymerase activity
GPY12_RS00500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY12_RS00515	COG1126	abc transporter atp-binding protein
GPY12_RS00520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY12_RS00525	COG0594	ribonuclease P activity
GPY12_RS00535	COG0706	membrane insertase activity
GPY12_RS00540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY12_RS00565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY12_RS00570	COG0445	tRNA wobble uridine modification
GPY12_RS00575	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY12_RS00580	COG1192	Involved in chromosome partitioning
GPY12_RS00585	COG1475	DNA binding
GPY12_RS00590	COG3312	ion transport
GPY12_RS00595	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY12_RS00605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY12_RS00610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY12_RS00615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY12_RS00620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY12_RS00625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY12_RS00630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY12_RS00640	COG2814	Major facilitator Superfamily
GPY12_RS00645	COG0583	DNA-binding transcription factor activity
GPY12_RS00650	COG0183	Belongs to the thiolase family
GPY12_RS00655	COG1024	Enoyl-CoA hydratase
GPY12_RS00655	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY12_RS00660	COG1739	Uncharacterized protein family UPF0029
GPY12_RS00665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY12_RS00740	COG0583	DNA-binding transcription factor activity
GPY12_RS00745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY12_RS00750	COG2960	long-chain fatty acid transporting porin activity
GPY12_RS00755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY12_RS00760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY12_RS00765	COG1309	transcriptional regulator
GPY12_RS00810	COG0747	negative chemotaxis
GPY12_RS00820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY12_RS00920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY12_RS00925	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY12_RS00935	COG0210	DNA helicase
GPY12_RS00940	COG1280	lysine exporter protein (LysE YggA)
GPY12_RS00955	COG2962	Rard protein
GPY12_RS00960	COG0514	ATP-dependent DNA helicase (RecQ)
GPY12_RS00975	COG4774	siderophore transport
GPY12_RS00980	COG1120	ATPase activity
GPY12_RS01000	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY12_RS01005	COG1263	PTS System
GPY12_RS01005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY12_RS01015	COG1561	YicC-like family, N-terminal region
GPY12_RS01020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY12_RS01025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY12_RS01030	COG1560	Kdo2-lipid A biosynthetic process
GPY12_RS01035	COG1560	Kdo2-lipid A biosynthetic process
GPY12_RS01040	COG1309	transcriptional regulator
GPY12_RS01045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY12_RS01060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY12_RS01065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY12_RS01075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY12_RS01080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY12_RS01085	COG0859	PFAM glycosyl transferase family 9
GPY12_RS01090	COG0463	Glycosyl transferase, family 2
GPY12_RS01095	COG0859	PFAM glycosyl transferase family 9
GPY12_RS01100	COG3642	lipopolysaccharide core region biosynthetic process
GPY12_RS01130	COG1519	Transferase
GPY12_RS01165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY12_RS01200	COG1132	(ABC) transporter
GPY12_RS01240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY12_RS01250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY12_RS01270	COG1596	polysaccharide export
GPY12_RS01285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY12_RS01325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY12_RS01335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY12_RS01340	COG0668	transmembrane transport
GPY12_RS01345	COG1573	uracil-dna glycosylase
GPY12_RS01355	COG3068	Protein conserved in bacteria
GPY12_RS01360	COG1253	flavin adenine dinucleotide binding
GPY12_RS01365	COG0776	regulation of translation
GPY12_RS01375	COG0151	Belongs to the GarS family
GPY12_RS01380	COG0138	bifunctional purine biosynthesis protein purh
GPY12_RS01390	COG0789	Transcriptional regulator
GPY12_RS01395	COG3710	Transcriptional regulator
GPY12_RS01400	COG0531	amino acid
GPY12_RS01405	COG1982	Orn Lys Arg decarboxylase major
GPY12_RS01410	COG0840	transmembrane signaling receptor activity
GPY12_RS01425	COG0800	Aldolase
GPY12_RS01430	COG2610	gluconate transmembrane transporter activity
GPY12_RS01435	COG3265	gluconokinase activity
GPY12_RS01440	COG0129	dihydroxy-acid dehydratase activity
GPY12_RS01445	COG1609	Transcriptional regulator
GPY12_RS01450	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY12_RS01455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY12_RS01460	COG2264	protein methyltransferase activity
GPY12_RS01465	COG0439	Biotin carboxylase
GPY12_RS01470	COG0511	ligase activity, forming carbon-carbon bonds
GPY12_RS01475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY12_RS01480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY12_RS01495	COG2814	Major facilitator Superfamily
GPY12_RS01505	COG0248	Ppx GppA phosphatase
GPY12_RS01510	COG0513	Belongs to the DEAD box helicase family
GPY12_RS01515	COG3118	belongs to the thioredoxin family
GPY12_RS01520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY12_RS01530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY12_RS01580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY12_RS01590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY12_RS01600	COG1072	(Pantothenic acid kinase))
GPY12_RS01625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY12_RS01630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY12_RS01635	COG0250	Participates in transcription elongation, termination and antitermination
GPY12_RS01640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY12_RS01645	COG0081	regulation of translation
GPY12_RS01650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY12_RS01655	COG0222	ribosome binding
GPY12_RS01660	COG0085	RNA polymerase activity
GPY12_RS01665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY12_RS01670	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY12_RS01675	COG2816	NAD+ diphosphatase activity
GPY12_RS01680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY12_RS01695	COG4942	peptidase
GPY12_RS01700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY12_RS01710	COG0471	metal ion transport
GPY12_RS01715	COG0688	phosphatidylethanolamine metabolic process
GPY12_RS01720	COG1162	GTPase activity
GPY12_RS01725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY12_RS01775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY12_RS01780	COG0802	atpase or kinase
GPY12_RS01790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY12_RS01795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY12_RS01800	COG1923	regulation of RNA biosynthetic process
GPY12_RS01805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY12_RS01810	COG0330	HflC and HflK could
GPY12_RS01815	COG0330	HflC and HflK could
GPY12_RS01820	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY12_RS01825	COG2900	Belongs to the SlyX family
GPY12_RS01835	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY12_RS01840	COG2964	Protein conserved in bacteria
GPY12_RS01845	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY12_RS01850	COG2923	Belongs to the DsrF TusC family
GPY12_RS01860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPY12_RS01865	COG0049	tRNA binding
GPY12_RS01870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY12_RS01875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY12_RS01880	COG2906	2 iron, 2 sulfur cluster binding
GPY12_RS01890	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY12_RS01895	COG2965	DNA replication, synthesis of RNA primer
GPY12_RS01900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPY12_RS01905	COG0359	binds to the 23S rRNA
GPY12_RS01915	COG0305	Participates in initiation and elongation during chromosome replication
GPY12_RS01920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY12_RS01925	COG0432	Pfam Uncharacterised protein family UPF0047
GPY12_RS01930	COG0166	Belongs to the GPI family
GPY12_RS01940	COG0735	belongs to the Fur family
GPY12_RS01945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY12_RS01965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY12_RS01970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY12_RS01975	COG0175	sulfate reduction
GPY12_RS02035	COG0646	methionine synthase
GPY12_RS02035	COG1410	methionine synthase
GPY12_RS02040	COG0527	aspartate kinase activity
GPY12_RS02045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY12_RS02055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY12_RS02075	COG2200	EAL domain
GPY12_RS02075	COG2199	diguanylate cyclase activity
GPY12_RS02100	COG3409	Peptidoglycan-binding domain 1 protein
GPY12_RS02100	COG3267	Type II secretory pathway component ExeA
GPY12_RS02110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY12_RS02115	COG1459	type II secretion system
GPY12_RS02160	COG1077	Cell shape determining protein MreB Mrl
GPY12_RS02165	COG1792	Involved in formation and maintenance of cell shape
GPY12_RS02170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY12_RS02175	COG0424	maF-like protein
GPY12_RS02180	COG1530	ribonuclease E activity
GPY12_RS02185	COG3164	Protein of unknown function
GPY12_RS02190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY12_RS02195	COG0312	modulator of DNA gyrase
GPY12_RS02200	COG1151	hydroxylamine reductase activity
GPY12_RS02205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY12_RS02210	COG2235	arginine
GPY12_RS02220	COG1737	Transcriptional regulator
GPY12_RS02220	COG0837	glucose binding
GPY12_RS02230	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GPY12_RS02240	COG4145	pantothenate transmembrane transporter activity
GPY12_RS02265	COG0589	response to stress
GPY12_RS02280	COG1438	arginine binding
GPY12_RS02285	COG0039	L-malate dehydrogenase activity
GPY12_RS02290	COG0531	amino acid
GPY12_RS02295	COG0142	geranyltranstransferase activity
GPY12_RS02300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY12_RS02305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY12_RS02310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY12_RS02315	COG2966	Psort location CytoplasmicMembrane, score
GPY12_RS02320	COG3610	response to peptide
GPY12_RS02330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY12_RS02335	COG2967	ApaG domain
GPY12_RS02340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY12_RS02345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY12_RS02350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY12_RS02355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY12_RS02360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY12_RS02415	COG0741	lytic transglycosylase activity
GPY12_RS02420	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY12_RS02425	COG1194	a g-specific adenine glycosylase
GPY12_RS02430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY12_RS02435	COG2066	Belongs to the glutaminase family
GPY12_RS02445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY12_RS02450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY12_RS02465	COG0762	integral membrane protein
GPY12_RS02470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY12_RS02475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY12_RS02495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY12_RS02500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY12_RS02505	COG1678	Uncharacterized ACR, COG1678
GPY12_RS02510	COG0189	ligase activity
GPY12_RS02515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY12_RS02520	COG2356	endonuclease I
GPY12_RS02525	COG3091	SprT-like family
GPY12_RS02530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY12_RS02540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY12_RS02545	COG0583	DNA-binding transcription factor activity
GPY12_RS02550	COG4771	TonB-dependent receptor
GPY12_RS02555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY12_RS02560	COG0126	phosphoglycerate kinase activity
GPY12_RS02565	COG0191	fructose-bisphosphate aldolase activity
GPY12_RS02570	COG0668	transmembrane transport
GPY12_RS02575	COG1279	arginine transmembrane transporter activity
GPY12_RS02580	COG0583	DNA-binding transcription factor activity
GPY12_RS02590	COG0469	pyruvate kinase activity
GPY12_RS02595	COG1349	DNA-binding transcription factor activity
GPY12_RS02600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY12_RS02605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY12_RS02620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY12_RS02625	COG0358	DNA primase activity
GPY12_RS02630	COG1610	YqeY-like protein
GPY12_RS02635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY12_RS02640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY12_RS02645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPY12_RS02650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY12_RS02655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY12_RS02660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY12_RS02665	COG1968	undecaprenyl-diphosphatase activity
GPY12_RS02670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY12_RS02675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY12_RS02680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY12_RS02685	COG0585	pseudouridine synthase activity
GPY12_RS02690	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY12_RS02695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY12_RS02700	COG1388	LysM domain
GPY12_RS02700	COG4942	peptidase
GPY12_RS02705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY12_RS02710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY12_RS02730	COG4208	sulfate ABC transporter
GPY12_RS02735	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPY12_RS02740	COG1546	Belongs to the CinA family
GPY12_RS02745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY12_RS02750	COG2137	regulation of response to DNA damage stimulus
GPY12_RS02755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY12_RS02760	COG0527	aspartate kinase activity
GPY12_RS02765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPY12_RS02810	COG3630	sodium ion export across plasma membrane
GPY12_RS02815	COG0511	ligase activity, forming carbon-carbon bonds
GPY12_RS02815	COG5016	pyruvate
GPY12_RS02820	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY12_RS02830	COG1238	metal cluster binding
GPY12_RS02835	COG0612	Peptidase, M16
GPY12_RS02840	COG2918	glutathione biosynthetic process
GPY12_RS02845	COG1854	S-ribosylhomocysteine lyase activity
GPY12_RS02850	COG4536	flavin adenine dinucleotide binding
GPY12_RS02855	COG4137	Cytochrome C assembly protein
GPY12_RS02860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY12_RS02865	COG0228	four-way junction DNA binding
GPY12_RS02870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY12_RS02875	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY12_RS02880	COG0335	large ribosomal subunit rRNA binding
GPY12_RS02885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY12_RS02890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY12_RS02900	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY12_RS02910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY12_RS02915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY12_RS02920	COG0723	plastoquinol--plastocyanin reductase activity
GPY12_RS02925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY12_RS02930	COG2857	Cytochrome c1
GPY12_RS02935	COG0625	glutathione transferase activity
GPY12_RS02940	COG2969	positive regulation of protein catabolic process
GPY12_RS02945	COG2823	Periplasmic or secreted lipoprotein
GPY12_RS02950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY12_RS02955	COG0792	nuclease activity
GPY12_RS02960	COG3107	peptidoglycan biosynthetic process
GPY12_RS02965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY12_RS02980	COG0288	reversible hydration of carbon dioxide
GPY12_RS02985	COG0659	secondary active sulfate transmembrane transporter activity
GPY12_RS02990	COG1131	(ABC) transporter
GPY12_RS02995	COG0842	Transport permease protein
GPY12_RS03000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY12_RS03005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY12_RS03010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY12_RS03020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY12_RS03025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY12_RS03030	COG1489	DNA binding
GPY12_RS03035	COG1643	Atp-dependent helicase
GPY12_RS03040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY12_RS03045	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY12_RS03055	COG3112	Uncharacterised protein family (UPF0231)
GPY12_RS03060	COG0347	Belongs to the P(II) protein family
GPY12_RS03065	COG0004	ammonium transporteR
GPY12_RS03070	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY12_RS03080	COG3842	ATPase activity
GPY12_RS03085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY12_RS03100	COG2971	BadF BadG BcrA BcrD
GPY12_RS03110	COG4608	Belongs to the ABC transporter superfamily
GPY12_RS03115	COG0444	Belongs to the ABC transporter superfamily
GPY12_RS03120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY12_RS03130	COG0747	negative chemotaxis
GPY12_RS03140	COG2813	Specifically methylates the guanine in position
GPY12_RS03145	COG0628	permease
GPY12_RS03155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY12_RS03160	COG0316	Belongs to the HesB IscA family
GPY12_RS03175	COG0739	heme binding
GPY12_RS03180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY12_RS03185	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY12_RS03190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY12_RS03195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY12_RS03200	COG1534	Rna-binding protein
GPY12_RS03205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY12_RS03210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY12_RS03215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY12_RS03220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY12_RS03225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY12_RS03240	COG0779	Required for maturation of 30S ribosomal subunits
GPY12_RS03245	COG0195	Participates in both transcription termination and antitermination
GPY12_RS03250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY12_RS03255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY12_RS03260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY12_RS03265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY12_RS03270	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY12_RS03275	COG4785	May be involved in cell division
GPY12_RS03280	COG1846	Transcriptional regulator
GPY12_RS03310	COG3153	acetyltransferase
GPY12_RS03330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY12_RS03335	COG0513	Belongs to the DEAD box helicase family
GPY12_RS03340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY12_RS03355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY12_RS03360	COG2204	response regulator
GPY12_RS03370	COG0667	Aldo Keto reductase
GPY12_RS03375	COG3066	DNA modification
GPY12_RS03380	COG0494	nUDIX hydrolase
GPY12_RS03385	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPY12_RS03390	COG0730	response to heat
GPY12_RS03395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY12_RS03400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY12_RS03405	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY12_RS03410	COG0583	DNA-binding transcription factor activity
GPY12_RS03415	COG0640	Transcriptional regulator
GPY12_RS03420	COG0268	Binds directly to 16S ribosomal RNA
GPY12_RS03425	COG0728	peptidoglycan biosynthetic process
GPY12_RS03430	COG0196	riboflavin kinase activity
GPY12_RS03435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY12_RS03440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY12_RS03445	COG1047	Peptidyl-prolyl cis-trans
GPY12_RS03450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY12_RS03455	COG1966	Carbon starvation protein
GPY12_RS03470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY12_RS03475	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY12_RS03480	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY12_RS03485	COG3279	Response regulator of the LytR AlgR family
GPY12_RS03490	COG3275	phosphorelay sensor kinase activity
GPY12_RS03495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY12_RS03500	COG1605	Chorismate mutase
GPY12_RS03500	COG0287	Prephenate dehydrogenase
GPY12_RS03510	COG0488	(ABC) transporter
GPY12_RS03520	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY12_RS03525	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY12_RS03530	COG5001	Diguanylate cyclase
GPY12_RS03535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY12_RS03540	COG0077	Prephenate dehydratase
GPY12_RS03540	COG1605	Chorismate mutase
GPY12_RS03545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY12_RS03550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY12_RS03555	COG0564	pseudouridine synthase activity
GPY12_RS03620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY12_RS03630	COG2974	May be involved in recombination
GPY12_RS03635	COG0745	RESPONSE REGULATOR receiver
GPY12_RS03640	COG5002	protein histidine kinase activity
GPY12_RS03650	COG0248	Ppx GppA phosphatase
GPY12_RS03655	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY12_RS03665	COG0581	inorganic phosphate transmembrane transporter activity
GPY12_RS03670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY12_RS03685	COG3142	Participates in the control of copper homeostasis
GPY12_RS03690	COG0450	alkyl hydroperoxide reductase
GPY12_RS03695	COG0583	DNA-binding transcription factor activity
GPY12_RS03700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY12_RS03710	COG0840	transmembrane signaling receptor activity
GPY12_RS03715	COG0517	IMP dehydrogenase activity
GPY12_RS03720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY12_RS03725	COG0343	queuine tRNA-ribosyltransferase activity
GPY12_RS03730	COG1862	Preprotein translocase
GPY12_RS03735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY12_RS03740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY12_RS03745	COG0483	inositol monophosphate 1-phosphatase activity
GPY12_RS03755	COG1959	2 iron, 2 sulfur cluster binding
GPY12_RS03765	COG0822	iron-sulfur transferase activity
GPY12_RS03775	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY12_RS03785	COG0633	Ferredoxin
GPY12_RS03790	COG2975	iron-sulfur cluster assembly
GPY12_RS03795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY12_RS03800	COG0105	UTP biosynthetic process
GPY12_RS03805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY12_RS03810	COG1426	Protein conserved in bacteria
GPY12_RS03815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY12_RS03820	COG0124	histidyl-tRNA synthetase
GPY12_RS03825	COG2976	Protein conserved in bacteria
GPY12_RS03830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY12_RS03835	COG1160	GTP binding
GPY12_RS03850	COG1570	exodeoxyribonuclease VII activity
GPY12_RS03855	COG0517	IMP dehydrogenase activity
GPY12_RS03855	COG0516	GMP reductase activity
GPY12_RS03860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY12_RS03860	COG0519	Catalyzes the synthesis of GMP from XMP
GPY12_RS03870	COG1584	GPR1 FUN34 yaaH family protein
GPY12_RS03875	COG0583	DNA-binding transcription factor activity
GPY12_RS03880	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY12_RS03885	COG1115	amino acid carrier protein
GPY12_RS03890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY12_RS03895	COG0583	DNA-binding transcription factor activity
GPY12_RS03910	COG2200	EAL domain
GPY12_RS03920	COG4565	transcriptional regulatory protein
GPY12_RS03930	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY12_RS03935	COG0511	ligase activity, forming carbon-carbon bonds
GPY12_RS03935	COG5016	pyruvate
GPY12_RS03940	COG3630	sodium ion export across plasma membrane
GPY12_RS03950	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPY12_RS03955	COG3052	prosthetic group binding
GPY12_RS03960	COG2301	Belongs to the HpcH HpaI aldolase family
GPY12_RS03965	COG3051	citrate lyase alpha subunit
GPY12_RS03970	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPY12_RS03975	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPY12_RS03985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY12_RS03990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY12_RS03995	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY12_RS04035	COG2003	Belongs to the UPF0758 family
GPY12_RS04045	COG1737	Transcriptional regulator
GPY12_RS04060	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY12_RS04065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY12_RS04090	COG0494	nUDIX hydrolase
GPY12_RS04115	COG2801	Transposase and inactivated derivatives
GPY12_RS04130	COG1715	Restriction endonuclease
GPY12_RS04135	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GPY12_RS04145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY12_RS04155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY12_RS04165	COG2801	Transposase and inactivated derivatives
GPY12_RS04170	COG0582	viral genome integration into host DNA
GPY12_RS04180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY12_RS04185	COG2867	negative regulation of translational initiation
GPY12_RS04190	COG2914	Belongs to the UPF0125 (RnfH) family
GPY12_RS04195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY12_RS04200	COG0497	DNA recombination
GPY12_RS04205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY12_RS04210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY12_RS04215	COG0443	Heat shock 70 kDa protein
GPY12_RS04220	COG0484	heat shock protein binding
GPY12_RS04250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY12_RS04255	COG0590	tRNA wobble adenosine to inosine editing
GPY12_RS04260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY12_RS04270	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY12_RS04270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY12_RS04290	COG0442	prolyl-tRNA aminoacylation
GPY12_RS04295	COG1720	tRNA m6t6A37 methyltransferase activity
GPY12_RS04300	COG0254	rRNA binding
GPY12_RS04305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY12_RS04310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY12_RS04315	COG1671	Belongs to the UPF0178 family
GPY12_RS04345	COG0564	pseudouridine synthase activity
GPY12_RS04350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY12_RS04355	COG0142	geranyltranstransferase activity
GPY12_RS04360	COG1722	exodeoxyribonuclease VII activity
GPY12_RS04365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY12_RS04375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY12_RS04375	COG0301	tRNA thio-modification
GPY12_RS04380	COG0583	DNA-binding transcription factor activity
GPY12_RS04385	COG2363	Small membrane protein
GPY12_RS04390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY12_RS04395	COG1611	Belongs to the LOG family
GPY12_RS04400	COG3706	GGDEF domain
GPY12_RS04410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY12_RS04410	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY12_RS04420	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY12_RS04425	COG1464	Belongs to the NlpA lipoprotein family
GPY12_RS04430	COG2011	ABC-type metal ion transport system permease component
GPY12_RS04435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY12_RS04440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY12_RS04445	COG1609	Transcriptional regulator
GPY12_RS04450	COG1263	PTS System
GPY12_RS04450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY12_RS04455	COG0366	Alpha amylase catalytic
GPY12_RS04460	COG0745	RESPONSE REGULATOR receiver
GPY12_RS04465	COG2205	protein histidine kinase activity
GPY12_RS04505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY12_RS04510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY12_RS04515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY12_RS04520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY12_RS04545	COG1045	serine acetyltransferase
GPY12_RS04565	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPY12_RS04595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY12_RS04605	COG1596	polysaccharide export
GPY12_RS04630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY12_RS04640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY12_RS04645	COG0321	lipoyl(octanoyl) transferase activity
GPY12_RS04650	COG2921	Belongs to the UPF0250 family
GPY12_RS04655	COG1686	Belongs to the peptidase S11 family
GPY12_RS04660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY12_RS04665	COG0772	Belongs to the SEDS family
GPY12_RS04670	COG0768	penicillin binding
GPY12_RS04675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY12_RS04680	COG0799	negative regulation of ribosome biogenesis
GPY12_RS04685	COG1466	dna polymerase III delta subunit
GPY12_RS04690	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY12_RS04695	COG0495	leucyl-tRNA aminoacylation
GPY12_RS04700	COG2888	peptidyl-tyrosine sulfation
GPY12_RS04705	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY12_RS04710	COG4535	Mg2 and Co2 transporter CorC
GPY12_RS04715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY12_RS04720	COG1702	phosphate starvation-inducible protein PhoH
GPY12_RS04725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY12_RS04730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY12_RS04735	COG2190	(PTS) system
GPY12_RS04745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS04750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY12_RS04755	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY12_RS04760	COG3115	cell septum assembly
GPY12_RS04765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY12_RS04780	COG0789	Transcriptional regulator
GPY12_RS04785	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPY12_RS04790	COG0330	HflC and HflK could
GPY12_RS04795	COG3118	belongs to the thioredoxin family
GPY12_RS04805	COG0300	oxidoreductase activity
GPY12_RS04810	COG1090	epimerase
GPY12_RS04815	COG0622	Phosphoesterase
GPY12_RS04830	COG3710	Transcriptional regulator
GPY12_RS04835	COG0326	Molecular chaperone. Has ATPase activity
GPY12_RS04840	COG0563	adenylate kinase activity
GPY12_RS04845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY12_RS04855	COG0250	Participates in transcription elongation, termination and antitermination
GPY12_RS04860	COG0367	asparagine synthase
GPY12_RS04865	COG4651	solute:proton antiporter activity
GPY12_RS04865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY12_RS04870	COG1846	Transcriptional regulator
GPY12_RS04870	COG1940	carbohydrate kinase activity
GPY12_RS04875	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY12_RS04880	COG1263	PTS System
GPY12_RS04880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY12_RS04880	COG2190	(PTS) system
GPY12_RS04885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY12_RS04895	COG0101	tRNA pseudouridine synthase activity
GPY12_RS04905	COG0285	dihydrofolate synthase activity
GPY12_RS04910	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY12_RS04915	COG1286	toxin biosynthetic process
GPY12_RS04920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY12_RS04925	COG2056	Na+-H+ antiporter family
GPY12_RS04930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY12_RS04945	COG0346	lactoylglutathione lyase activity
GPY12_RS04950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY12_RS04955	COG4660	Part of a membrane complex involved in electron transport
GPY12_RS04960	COG4659	FMN binding
GPY12_RS04965	COG4658	electron transport chain
GPY12_RS04970	COG4656	Part of a membrane complex involved in electron transport
GPY12_RS04975	COG2878	Part of a membrane complex involved in electron transport
GPY12_RS04980	COG4657	Part of a membrane complex involved in electron transport
GPY12_RS05015	COG0714	Associated with various cellular activities
GPY12_RS05020	COG0641	radical SAM
GPY12_RS05025	COG3119	arylsulfatase activity
GPY12_RS05040	COG0556	nucleotide-excision repair
GPY12_RS05045	COG2204	response regulator
GPY12_RS05050	COG2198	Histidine kinase
GPY12_RS05055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY12_RS05060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY12_RS05065	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY12_RS05070	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY12_RS05075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY12_RS05080	COG0314	molybdopterin synthase activity
GPY12_RS05085	COG3706	GGDEF domain
GPY12_RS05090	COG0517	IMP dehydrogenase activity
GPY12_RS05090	COG0516	GMP reductase activity
GPY12_RS05100	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY12_RS05110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY12_RS05110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY12_RS05120	COG0572	uridine kinase
GPY12_RS05125	COG2982	Protein involved in outer membrane biogenesis
GPY12_RS05130	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY12_RS05135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY12_RS05140	COG2067	long-chain fatty acid transport protein
GPY12_RS05145	COG2067	long-chain fatty acid transport protein
GPY12_RS05160	COG0183	Belongs to the thiolase family
GPY12_RS05165	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY12_RS05165	COG1024	Enoyl-CoA hydratase
GPY12_RS05170	COG0778	Nitroreductase
GPY12_RS05175	COG0583	DNA-binding transcription factor activity
GPY12_RS05180	COG0745	RESPONSE REGULATOR receiver
GPY12_RS05190	COG2832	Protein of unknown function (DUF454)
GPY12_RS05195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY12_RS05200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GPY12_RS05205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY12_RS05210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY12_RS05225	COG1028	Short-chain dehydrogenase reductase Sdr
GPY12_RS05230	COG0616	signal peptide processing
GPY12_RS05240	COG1522	sequence-specific DNA binding
GPY12_RS05245	COG1946	Acyl-CoA thioesterase
GPY12_RS05265	COG3300	MHYT domain
GPY12_RS05265	COG5001	Diguanylate cyclase
GPY12_RS05320	COG4264	IucA IucC family
GPY12_RS05330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY12_RS05335	COG1120	ATPase activity
GPY12_RS05355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GPY12_RS05360	COG2076	Multidrug Resistance protein
GPY12_RS05365	COG2076	Multidrug Resistance protein
GPY12_RS05370	COG0590	tRNA wobble adenosine to inosine editing
GPY12_RS05380	COG0640	Transcriptional regulator
GPY12_RS05385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY12_RS05405	COG1349	DNA-binding transcription factor activity
GPY12_RS05415	COG2222	sugar isomerase
GPY12_RS05420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY12_RS05425	COG3715	PTS system
GPY12_RS05430	COG3716	PTS system mannose fructose sorbose family IID component
GPY12_RS05435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS05460	COG1881	PFAM PEBP family protein
GPY12_RS05475	COG0009	L-threonylcarbamoyladenylate synthase
GPY12_RS05490	COG2201	protein-glutamate methylesterase activity
GPY12_RS05500	COG5002	protein histidine kinase activity
GPY12_RS05505	COG4191	Histidine kinase
GPY12_RS05510	COG5001	Diguanylate cyclase
GPY12_RS05510	COG3300	MHYT domain
GPY12_RS05515	COG2204	response regulator
GPY12_RS05535	COG0601	transmembrane transport
GPY12_RS05540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY12_RS05550	COG4608	Belongs to the ABC transporter superfamily
GPY12_RS05555	COG0435	Glutathione S-transferase
GPY12_RS05560	COG0857	belongs to the CobB CobQ family
GPY12_RS05560	COG0280	phosphate acetyltransferase
GPY12_RS05565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY12_RS05570	COG3092	negative regulation of chromosome organization
GPY12_RS05575	COG4628	conserved protein (DUF2132)
GPY12_RS05585	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY12_RS05595	COG3706	GGDEF domain
GPY12_RS05600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY12_RS05610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY12_RS05615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY12_RS05620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY12_RS05625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY12_RS05630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY12_RS05635	COG0156	8-amino-7-oxononanoate synthase activity
GPY12_RS05640	COG2226	methyltransferase
GPY12_RS05640	COG1073	alpha beta
GPY12_RS05645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY12_RS05655	COG0501	Belongs to the peptidase M48B family
GPY12_RS05665	COG0300	oxidoreductase activity
GPY12_RS05680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY12_RS05690	COG2268	Band 7 protein
GPY12_RS05695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY12_RS05700	COG2915	High frequency lysogenization protein hflD homolog
GPY12_RS05705	COG0482	sulfurtransferase activity
GPY12_RS05710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY12_RS05715	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY12_RS05720	COG1757	Na H antiporter
GPY12_RS05725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY12_RS05730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY12_RS05735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY12_RS05740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY12_RS05740	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY12_RS05745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY12_RS05750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY12_RS05755	COG0107	imidazoleglycerol-phosphate synthase activity
GPY12_RS05760	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY12_RS05760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY12_RS05765	COG1187	pseudouridine synthase activity
GPY12_RS05775	COG1278	Cold shock
GPY12_RS05780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY12_RS05785	COG0542	response to heat
GPY12_RS05795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY12_RS05800	COG1979	alcohol dehydrogenase
GPY12_RS05805	COG1737	Transcriptional regulator
GPY12_RS05810	COG0076	glutamate decarboxylase activity
GPY12_RS05820	COG2431	L-lysine efflux transmembrane transporter activity
GPY12_RS05830	COG3070	regulator of competence-specific genes
GPY12_RS05845	COG3852	Histidine kinase
GPY12_RS05855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY12_RS05870	COG0189	ligase activity
GPY12_RS05870	COG4067	protein conserved in archaea
GPY12_RS05875	COG0500	methyltransferase
GPY12_RS05880	COG4106	trans-aconitate 2-methyltransferase activity
GPY12_RS05885	COG1801	Protein of unknown function DUF72
GPY12_RS05890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY12_RS05895	COG1435	thymidine kinase activity
GPY12_RS05905	COG0159	tryptophan synthase activity
GPY12_RS05910	COG0133	tryptophan synthase activity
GPY12_RS05915	COG0134	indole-3-glycerol-phosphate synthase activity
GPY12_RS05915	COG0135	phosphoribosylanthranilate isomerase activity
GPY12_RS05920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY12_RS05925	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY12_RS05930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY12_RS05940	COG0613	PHP domain protein
GPY12_RS05945	COG0009	L-threonylcarbamoyladenylate synthase
GPY12_RS05950	COG1187	pseudouridine synthase activity
GPY12_RS05955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY12_RS05960	COG4988	ABC transporter
GPY12_RS05965	COG0492	ferredoxin-NADP+ reductase activity
GPY12_RS05975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY12_RS05980	COG3706	GGDEF domain
GPY12_RS05985	COG2949	membrane
GPY12_RS05995	COG0281	malic enzyme
GPY12_RS06005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY12_RS06025	COG2885	chlorophyll binding
GPY12_RS06040	COG0277	FAD linked oxidase domain protein
GPY12_RS06040	COG0247	lactate metabolic process
GPY12_RS06065	COG2986	histidine ammonia-lyase
GPY12_RS06070	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY12_RS06075	COG0010	Belongs to the arginase family
GPY12_RS06080	COG1228	amidohydrolase
GPY12_RS06100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY12_RS06110	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY12_RS06115	COG0417	DNA replication proofreading
GPY12_RS06120	COG2197	response regulator
GPY12_RS06125	COG0322	excinuclease ABC activity
GPY12_RS06155	COG3706	GGDEF domain
GPY12_RS06160	COG0456	acetyltransferase
GPY12_RS06165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY12_RS06170	COG0072	phenylalanine-tRNA ligase activity
GPY12_RS06170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY12_RS06175	COG0776	regulation of translation
GPY12_RS06185	COG0500	methyltransferase
GPY12_RS06200	COG0295	cytidine deaminase activity
GPY12_RS06205	COG1346	cytolysis
GPY12_RS06215	COG2925	Exonuclease
GPY12_RS06220	COG0582	viral genome integration into host DNA
GPY12_RS06255	COG1484	DNA-dependent DNA replication
GPY12_RS06295	COG2801	Transposase and inactivated derivatives
GPY12_RS06300	COG3335	DDE superfamily endonuclease
GPY12_RS06305	COG2801	Transposase and inactivated derivatives
GPY12_RS06335	COG2801	Transposase and inactivated derivatives
GPY12_RS06350	COG3436	PFAM IS66 Orf2 family protein
GPY12_RS06355	COG4372	Transposase
GPY12_RS06385	COG3328	transposase activity
GPY12_RS06390	COG3064	Membrane
GPY12_RS06400	COG3328	transposase activity
GPY12_RS06425	COG3328	transposase activity
GPY12_RS06435	COG2801	Transposase and inactivated derivatives
GPY12_RS06525	COG4789	Type iii secretion
GPY12_RS06530	COG4792	protein secretion
GPY12_RS06560	COG3710	Transcriptional regulator
GPY12_RS06570	COG4790	Type iii secretion
GPY12_RS06655	COG2801	Transposase and inactivated derivatives
GPY12_RS06675	COG2801	Transposase and inactivated derivatives
GPY12_RS06680	COG3328	transposase activity
GPY12_RS06715	COG3335	DDE superfamily endonuclease
GPY12_RS06730	COG1484	DNA-dependent DNA replication
GPY12_RS06745	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY12_RS06770	COG3335	DDE superfamily endonuclease
GPY12_RS06785	COG2801	Transposase and inactivated derivatives
GPY12_RS06910	COG3620	sequence-specific DNA binding
GPY12_RS06955	COG3328	transposase activity
GPY12_RS06975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY12_RS06980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY12_RS06985	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY12_RS07000	COG2988	succinylglutamate desuccinylase activity
GPY12_RS07005	COG4139	cobalamin transport
GPY12_RS07010	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY12_RS07060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY12_RS07065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY12_RS07085	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY12_RS07090	COG0437	4 iron, 4 sulfur cluster binding
GPY12_RS07095	COG3301	Polysulphide reductase, NrfD
GPY12_RS07100	COG1138	Cytochrome C-type biogenesis protein
GPY12_RS07110	COG4235	cytochrome complex assembly
GPY12_RS07110	COG3088	subunit of a heme lyase
GPY12_RS07120	COG1278	Cold shock
GPY12_RS07135	COG2814	Major facilitator Superfamily
GPY12_RS07145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY12_RS07175	COG3108	Peptidase M15
GPY12_RS07180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY12_RS07195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY12_RS07220	COG1846	Transcriptional regulator
GPY12_RS07225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY12_RS07230	COG0726	polysaccharide deacetylase
GPY12_RS07235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY12_RS07245	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY12_RS07250	COG1486	melibiose metabolic process
GPY12_RS07255	COG3394	polysaccharide catabolic process
GPY12_RS07260	COG1609	Transcriptional regulator
GPY12_RS07265	COG2943	transferase activity, transferring hexosyl groups
GPY12_RS07270	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPY12_RS07275	COG0840	transmembrane signaling receptor activity
GPY12_RS07290	COG1448	Aminotransferase
GPY12_RS07295	COG3437	response regulator, receiver
GPY12_RS07295	COG2770	Histidine kinase
GPY12_RS07300	COG0110	maltose O-acetyltransferase activity
GPY12_RS07305	COG0351	phosphomethylpyrimidine kinase
GPY12_RS07310	COG0017	Asparaginyl-tRNA synthetase
GPY12_RS07315	COG0840	transmembrane signaling receptor activity
GPY12_RS07320	COG0720	synthase
GPY12_RS07325	COG1760	l-serine dehydratase
GPY12_RS07330	COG0814	amino acid
GPY12_RS07335	COG0494	nUDIX hydrolase
GPY12_RS07355	COG3106	COG3106 Predicted ATPase
GPY12_RS07360	COG3768	UPF0283 membrane protein
GPY12_RS07365	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY12_RS07370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY12_RS07390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY12_RS07395	COG0840	transmembrane signaling receptor activity
GPY12_RS07400	COG0471	metal ion transport
GPY12_RS07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY12_RS07405	COG4191	Histidine kinase
GPY12_RS07420	COG3713	MltA-interacting MipA family protein
GPY12_RS07425	COG5002	protein histidine kinase activity
GPY12_RS07430	COG0745	RESPONSE REGULATOR receiver
GPY12_RS07455	COG1129	ABC transporter
GPY12_RS07485	COG2814	Major facilitator Superfamily
GPY12_RS07505	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY12_RS07515	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY12_RS07520	COG0372	Belongs to the citrate synthase family
GPY12_RS07550	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY12_RS07560	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY12_RS07570	COG0625	glutathione transferase activity
GPY12_RS07575	COG3437	response regulator, receiver
GPY12_RS07590	COG3706	GGDEF domain
GPY12_RS07595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY12_RS07605	COG1254	Belongs to the acylphosphatase family
GPY12_RS07610	COG2920	part of a sulfur-relay system
GPY12_RS07615	COG0670	Belongs to the BI1 family
GPY12_RS07620	COG1126	abc transporter atp-binding protein
GPY12_RS07625	COG0765	amino acid transport
GPY12_RS07630	COG4597	amino acid ABC transporter
GPY12_RS07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY12_RS07645	COG0561	phosphatase activity
GPY12_RS07650	COG0602	queuosine metabolic process
GPY12_RS07655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY12_RS07685	COG3706	GGDEF domain
GPY12_RS07690	COG0443	Heat shock 70 kDa protein
GPY12_RS07695	COG0443	Heat shock 70 kDa protein
GPY12_RS07705	COG5001	Diguanylate cyclase
GPY12_RS07705	COG3300	MHYT domain
GPY12_RS07725	COG1643	Atp-dependent helicase
GPY12_RS07745	COG0402	S-adenosylhomocysteine deaminase activity
GPY12_RS07750	COG0443	Heat shock 70 kDa protein
GPY12_RS07755	COG0583	DNA-binding transcription factor activity
GPY12_RS07760	COG0477	Major facilitator Superfamily
GPY12_RS07765	COG2076	Multidrug Resistance protein
GPY12_RS07770	COG0840	transmembrane signaling receptor activity
GPY12_RS07780	COG0513	Belongs to the DEAD box helicase family
GPY12_RS07840	COG1846	Transcriptional regulator
GPY12_RS07860	COG3971	2-oxopent-4-enoate hydratase activity
GPY12_RS07880	COG1012	belongs to the aldehyde dehydrogenase family
GPY12_RS07895	COG3384	dioxygenase
GPY12_RS07900	COG1012	belongs to the aldehyde dehydrogenase family
GPY12_RS07915	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY12_RS07925	COG3501	Rhs element vgr protein
GPY12_RS07945	COG1280	lysine exporter protein (LysE YggA)
GPY12_RS07950	COG1115	amino acid carrier protein
GPY12_RS07965	COG2199	diguanylate cyclase activity
GPY12_RS07970	COG2202	Pas domain
GPY12_RS07970	COG2205	protein histidine kinase activity
GPY12_RS07985	COG1012	belongs to the aldehyde dehydrogenase family
GPY12_RS07990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY12_RS07995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY12_RS08000	COG1177	transmembrane transport
GPY12_RS08005	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY12_RS08010	COG3842	ATPase activity
GPY12_RS08030	COG0037	tRNA processing
GPY12_RS08035	COG0589	response to stress
GPY12_RS08040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY12_RS08055	COG2217	Heavy metal translocating P-type atpase
GPY12_RS08065	COG2010	Cytochrome c
GPY12_RS08080	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY12_RS08095	COG5002	protein histidine kinase activity
GPY12_RS08095	COG0784	Response regulator, receiver
GPY12_RS08170	COG3120	sequence-specific DNA binding
GPY12_RS08175	COG1067	ATP-dependent peptidase activity
GPY12_RS08180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY12_RS08205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY12_RS08205	COG0116	Belongs to the methyltransferase superfamily
GPY12_RS08215	COG0167	dihydroorotate dehydrogenase activity
GPY12_RS08230	COG0308	aminopeptidase N
GPY12_RS08245	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY12_RS08250	COG1956	GAF domain-containing protein
GPY12_RS08255	COG1132	(ABC) transporter
GPY12_RS08260	COG2995	paraquat-inducible protein a
GPY12_RS08265	COG3008	intermembrane lipid transfer
GPY12_RS08270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY12_RS08270	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY12_RS08275	COG2996	Protein conserved in bacteria
GPY12_RS08290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY12_RS08300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY12_RS08305	COG0004	ammonium transporteR
GPY12_RS08320	COG0437	4 iron, 4 sulfur cluster binding
GPY12_RS08325	COG0243	molybdopterin cofactor binding
GPY12_RS08325	COG3383	formate dehydrogenase (NAD+) activity
GPY12_RS08355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY12_RS08365	COG0488	(ABC) transporter
GPY12_RS08370	COG3852	Histidine kinase
GPY12_RS08385	COG4662	Binding-protein-dependent transport system inner membrane component
GPY12_RS08390	COG3842	ATPase activity
GPY12_RS08395	COG0746	molybdenum cofactor guanylyltransferase activity
GPY12_RS08410	COG1940	carbohydrate kinase activity
GPY12_RS08425	COG0840	transmembrane signaling receptor activity
GPY12_RS08430	COG0791	NLP P60 protein
GPY12_RS08450	COG0534	Mate efflux family protein
GPY12_RS08460	COG1793	dna ligase
GPY12_RS08475	COG0848	biopolymer transport protein
GPY12_RS08480	COG0811	peptide transport
GPY12_RS08485	COG0811	peptide transport
GPY12_RS08495	COG1653	transport
GPY12_RS08505	COG0395	ABC-type sugar transport system, permease component
GPY12_RS08510	COG3842	ATPase activity
GPY12_RS08515	COG1349	DNA-binding transcription factor activity
GPY12_RS08520	COG0584	glycerophosphoryl diester phosphodiesterase
GPY12_RS08525	COG2731	YhcH YjgK YiaL family protein
GPY12_RS08530	COG0251	oxidation-reduction process
GPY12_RS08535	COG1609	Transcriptional regulator
GPY12_RS08540	COG2723	6-phospho-beta-galactosidase activity
GPY12_RS08545	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY12_RS08570	COG1136	(ABC) transporter
GPY12_RS08570	COG0577	efflux transmembrane transporter activity
GPY12_RS08580	COG1136	(ABC) transporter
GPY12_RS08580	COG0577	efflux transmembrane transporter activity
GPY12_RS08590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY12_RS08595	COG1780	Probably involved in ribonucleotide reductase function
GPY12_RS08610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY12_RS08615	COG0719	Fe-S assembly protein
GPY12_RS08620	COG0396	ATPase activity
GPY12_RS08625	COG0719	Fe-S assembly protein
GPY12_RS08630	COG0316	Belongs to the HesB IscA family
GPY12_RS08670	COG0753	catalase activity
GPY12_RS08675	COG3059	membrane
GPY12_RS08680	COG3064	Membrane
GPY12_RS08690	COG2017	converts alpha-aldose to the beta-anomer
GPY12_RS08695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY12_RS08700	COG1085	galactose-1-phosphate uridylyltransferase
GPY12_RS08720	COG3706	GGDEF domain
GPY12_RS08720	COG0745	RESPONSE REGULATOR receiver
GPY12_RS08735	COG0835	chemotaxis
GPY12_RS08735	COG0784	Response regulator, receiver
GPY12_RS08745	COG4565	transcriptional regulatory protein
GPY12_RS08750	COG3290	protein histidine kinase activity
GPY12_RS08765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY12_RS08785	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY12_RS08790	COG3063	Type IV pilus biogenesis stability protein PilW
GPY12_RS08805	COG1451	nucleotide metabolic process
GPY12_RS08815	COG0583	DNA-binding transcription factor activity
GPY12_RS08855	COG1538	Outer membrane efflux protein
GPY12_RS08865	COG0019	diaminopimelate decarboxylase activity
GPY12_RS08870	COG1748	Saccharopine dehydrogenase
GPY12_RS08880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY12_RS08895	COG4181	ATPase activity
GPY12_RS08900	COG0534	Mate efflux family protein
GPY12_RS08905	COG0702	epimerase
GPY12_RS08915	COG2814	Major facilitator Superfamily
GPY12_RS08920	COG1187	pseudouridine synthase activity
GPY12_RS08925	COG1061	Type III restriction enzyme res subunit
GPY12_RS08935	COG0745	RESPONSE REGULATOR receiver
GPY12_RS08945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY12_RS08960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY12_RS08990	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GPY12_RS09010	COG4934	collagen metabolic process
GPY12_RS09025	COG0784	Response regulator, receiver
GPY12_RS09025	COG2205	protein histidine kinase activity
GPY12_RS09030	COG2239	Acts as a magnesium transporter
GPY12_RS09040	COG0814	amino acid
GPY12_RS09045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY12_RS09050	COG1131	(ABC) transporter
GPY12_RS09055	COG0842	Transport permease protein
GPY12_RS09065	COG3313	Fe-S protein
GPY12_RS09075	COG4134	Bacterial extracellular solute-binding protein
GPY12_RS09080	COG4135	transport system, permease component
GPY12_RS09085	COG4136	ATPase activity
GPY12_RS09090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY12_RS09095	COG0564	pseudouridine synthase activity
GPY12_RS09100	COG0733	neurotransmitter:sodium symporter activity
GPY12_RS09115	COG0519	Catalyzes the synthesis of GMP from XMP
GPY12_RS09120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPY12_RS09135	COG1842	Phage shock protein A
GPY12_RS09140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY12_RS09150	COG4168	peptide transport system, permease
GPY12_RS09155	COG4171	peptide transport system, permease
GPY12_RS09165	COG4172	Belongs to the ABC transporter superfamily
GPY12_RS09180	COG1227	inorganic diphosphatase activity
GPY12_RS09190	COG1162	GTPase activity
GPY12_RS09200	COG0243	molybdopterin cofactor binding
GPY12_RS09205	COG3005	denitrification pathway
GPY12_RS09210	COG4459	periplasmic nitrate reductase
GPY12_RS09215	COG2116	formate transmembrane transporter activity
GPY12_RS09225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY12_RS09230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY12_RS09245	COG2917	probably involved in intracellular septation
GPY12_RS09250	COG1607	acyl-coa hydrolase
GPY12_RS09255	COG2350	Protein conserved in bacteria
GPY12_RS09265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY12_RS09270	COG0583	DNA-binding transcription factor activity
GPY12_RS09285	COG0612	Peptidase, M16
GPY12_RS09290	COG2199	diguanylate cyclase activity
GPY12_RS09290	COG2203	Gaf domain
GPY12_RS09290	COG2200	EAL domain
GPY12_RS09295	COG1032	radical SAM domain protein
GPY12_RS09310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY12_RS09315	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY12_RS09320	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY12_RS09325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY12_RS09330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY12_RS09340	COG0745	RESPONSE REGULATOR receiver
GPY12_RS09345	COG3381	protein complex oligomerization
GPY12_RS09350	COG1609	Transcriptional regulator
GPY12_RS09355	COG3070	regulator of competence-specific genes
GPY12_RS09375	COG0297	glycogen (starch) synthase activity
GPY12_RS09380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY12_RS09385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY12_RS09395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY12_RS09400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY12_RS09405	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY12_RS09410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY12_RS09415	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY12_RS09420	COG1960	acyl-CoA dehydrogenase activity
GPY12_RS09445	COG1309	transcriptional regulator
GPY12_RS09450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY12_RS09460	COG2200	EAL domain
GPY12_RS09460	COG2771	luxR family
GPY12_RS09470	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY12_RS09475	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY12_RS09490	COG3250	beta-galactosidase activity
GPY12_RS09545	COG4964	Belongs to the GSP D family
GPY12_RS09590	COG0641	radical SAM
GPY12_RS09595	COG0583	DNA-binding transcription factor activity
GPY12_RS09630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY12_RS09635	COG3537	Alpha-1,2-mannosidase
GPY12_RS09640	COG3537	Alpha-1,2-mannosidase
GPY12_RS09650	COG3537	Alpha-1,2-mannosidase
GPY12_RS09665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY12_RS09670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY12_RS09680	COG2207	Transcriptional regulator
GPY12_RS09685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS09685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY12_RS09685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY12_RS09700	COG0784	Response regulator, receiver
GPY12_RS09700	COG5002	protein histidine kinase activity
GPY12_RS09710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY12_RS09720	COG2885	chlorophyll binding
GPY12_RS09725	COG0823	Involved in the tonB-independent uptake of proteins
GPY12_RS09740	COG0811	peptide transport
GPY12_RS09745	COG0824	Thioesterase
GPY12_RS09755	COG4890	Cyd operon protein YbgT
GPY12_RS09760	COG1294	oxidase, subunit
GPY12_RS09765	COG1271	oxidase subunit
GPY12_RS09770	COG2255	four-way junction helicase activity
GPY12_RS09775	COG0632	four-way junction helicase activity
GPY12_RS09780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY12_RS09785	COG0215	cysteine-tRNA ligase activity
GPY12_RS09790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY12_RS09795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY12_RS09800	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY12_RS09820	COG0730	response to heat
GPY12_RS09825	COG3923	Primosomal replication protein n
GPY12_RS09835	COG0840	transmembrane signaling receptor activity
GPY12_RS09840	COG0708	Exodeoxyribonuclease III
GPY12_RS09845	COG4160	amino acid transport
GPY12_RS09850	COG4215	(ABC) transporter
GPY12_RS09870	COG1882	Formate acetyltransferase
GPY12_RS09880	COG0840	transmembrane signaling receptor activity
GPY12_RS09885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY12_RS09895	COG3013	Belongs to the UPF0304 family
GPY12_RS09900	COG2766	serine protein kinase
GPY12_RS09905	COG2718	Belongs to the UPF0229 family
GPY12_RS09910	COG2719	SpoVR family
GPY12_RS09920	COG0745	RESPONSE REGULATOR receiver
GPY12_RS09935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY12_RS09945	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY12_RS09950	COG1132	(ABC) transporter
GPY12_RS09955	COG0658	competence protein
GPY12_RS09955	COG2333	competence protein COMEC
GPY12_RS09965	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY12_RS09970	COG1136	(ABC) transporter
GPY12_RS09975	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY12_RS09985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY12_RS10000	COG1252	NADH dehydrogenase
GPY12_RS10030	COG0537	adenosine 5'-monophosphoramidase activity
GPY12_RS10045	COG2186	Transcriptional regulator
GPY12_RS10050	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY12_RS10055	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY12_RS10060	COG1674	ftsk spoiiie
GPY12_RS10070	COG1522	sequence-specific DNA binding
GPY12_RS10075	COG0686	Belongs to the AlaDH PNT family
GPY12_RS10085	COG0583	DNA-binding transcription factor activity
GPY12_RS10110	COG4608	Belongs to the ABC transporter superfamily
GPY12_RS10115	COG0444	Belongs to the ABC transporter superfamily
GPY12_RS10120	COG4166	transmembrane transport
GPY12_RS10125	COG4239	(ABC) transporter, permease
GPY12_RS10130	COG0601	transmembrane transport
GPY12_RS10175	COG2204	response regulator
GPY12_RS10185	COG0438	transferase activity, transferring glycosyl groups
GPY12_RS10220	COG0438	transferase activity, transferring glycosyl groups
GPY12_RS10225	COG1215	transferase activity, transferring glycosyl groups
GPY12_RS10230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY12_RS10245	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY12_RS10250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY12_RS10255	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY12_RS10260	COG0776	regulation of translation
GPY12_RS10265	COG0539	negative regulation of cytoplasmic translation
GPY12_RS10270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY12_RS10275	COG1555	photosystem II stabilization
GPY12_RS10280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY12_RS10285	COG0776	regulation of translation
GPY12_RS10290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY12_RS10295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY12_RS10305	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY12_RS10315	COG4191	Histidine kinase
GPY12_RS10325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY12_RS10330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY12_RS10335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY12_RS10340	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY12_RS10355	COG3300	MHYT domain
GPY12_RS10355	COG5001	Diguanylate cyclase
GPY12_RS10365	COG4589	Belongs to the CDS family
GPY12_RS10385	COG0671	phosphoesterase, PA-phosphatase related
GPY12_RS10405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY12_RS10415	COG3325	Belongs to the glycosyl hydrolase 18 family
GPY12_RS10415	COG3469	chitinase activity
GPY12_RS10420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY12_RS10430	COG2951	lytic endotransglycosylase activity
GPY12_RS10435	COG3100	YcgL domain-containing protein
GPY12_RS10445	COG0850	regulation of cytokinetic process
GPY12_RS10450	COG2894	cell division
GPY12_RS10455	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY12_RS10460	COG3015	lipoprotein NlpE involved in copper resistance
GPY12_RS10480	COG0477	Major facilitator Superfamily
GPY12_RS10490	COG1396	sequence-specific DNA binding
GPY12_RS10495	COG3135	benzoate transporter
GPY12_RS10505	COG1441	menaquinone biosynthetic process
GPY12_RS10515	COG0596	Alpha beta hydrolase
GPY12_RS10520	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY12_RS10525	COG1169	isochorismate synthase
GPY12_RS10530	COG0436	Aminotransferase
GPY12_RS10535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY12_RS10540	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY12_RS10550	COG0705	Rhomboid family
GPY12_RS10560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY12_RS10565	COG0318	PFAM AMP-dependent synthetase and ligase
GPY12_RS10570	COG0596	Alpha beta hydrolase
GPY12_RS10585	COG1214	PFAM Peptidase M22, glycoprotease
GPY12_RS10590	COG1199	ATP-dependent helicase activity
GPY12_RS10600	COG0788	formyltetrahydrofolate deformylase activity
GPY12_RS10605	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY12_RS10605	COG1902	pentaerythritol trinitrate reductase activity
GPY12_RS10610	COG0616	signal peptide processing
GPY12_RS10615	COG0252	asparaginase activity
GPY12_RS10620	COG3139	Protein of unknown function (DUF1315)
GPY12_RS10630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY12_RS10635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY12_RS10650	COG2226	methyltransferase
GPY12_RS10680	COG0784	Response regulator, receiver
GPY12_RS10680	COG0835	chemotaxis
GPY12_RS10685	COG1940	carbohydrate kinase activity
GPY12_RS10695	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY12_RS10710	COG0733	neurotransmitter:sodium symporter activity
GPY12_RS10725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY12_RS10725	COG1263	PTS System
GPY12_RS10730	COG0084	hydrolase, TatD family'
GPY12_RS10740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY12_RS10745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY12_RS10750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY12_RS10755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY12_RS10760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY12_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
GPY12_RS10775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY12_RS10780	COG0416	fatty acid biosynthetic process
GPY12_RS10785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPY12_RS10790	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY12_RS10795	COG0424	maF-like protein
GPY12_RS10800	COG0564	pseudouridine synthase activity
GPY12_RS10805	COG1530	ribonuclease E activity
GPY12_RS10810	COG0659	secondary active sulfate transmembrane transporter activity
GPY12_RS10820	COG1454	alcohol dehydrogenase
GPY12_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
GPY12_RS10825	COG2095	MarC family integral membrane protein
GPY12_RS10830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY12_RS10835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY12_RS10840	COG1757	Na H antiporter
GPY12_RS10850	COG3081	Nucleoid-associated protein
GPY12_RS10860	COG3083	sulfuric ester hydrolase activity
GPY12_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
GPY12_RS10895	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY12_RS10900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY12_RS10905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY12_RS10925	COG2853	Lipoprotein
GPY12_RS10935	COG4235	cytochrome complex assembly
GPY12_RS10935	COG3088	subunit of a heme lyase
GPY12_RS10940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY12_RS10945	COG1138	Cytochrome C-type biogenesis protein
GPY12_RS10950	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY12_RS10960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY12_RS10965	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY12_RS10970	COG4133	protoheme IX ABC transporter activity
GPY12_RS10980	COG0835	chemotaxis
GPY12_RS10990	COG1192	Involved in chromosome partitioning
GPY12_RS10995	COG2201	protein-glutamate methylesterase activity
GPY12_RS11000	COG2198	Histidine kinase
GPY12_RS11000	COG0643	Histidine kinase
GPY12_RS11005	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY12_RS11020	COG0455	bacterial-type flagellum organization
GPY12_RS11035	COG2062	phosphohistidine phosphatase, SixA
GPY12_RS11040	COG1025	Belongs to the peptidase M16 family
GPY12_RS11050	COG0018	arginyl-trna synthetase
GPY12_RS11075	COG1918	ferrous iron import across plasma membrane
GPY12_RS11080	COG4977	sequence-specific DNA binding
GPY12_RS11085	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY12_RS11090	COG1121	(ABC) transporter
GPY12_RS11095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY12_RS11105	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY12_RS11110	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY12_RS11115	COG0567	Dehydrogenase, E1 component
GPY12_RS11125	COG1053	succinate dehydrogenase
GPY12_RS11130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY12_RS11135	COG2009	succinate dehydrogenase
GPY12_RS11140	COG0372	Belongs to the citrate synthase family
GPY12_RS11145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY12_RS11155	COG0033	Phosphoglucomutase
GPY12_RS11160	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY12_RS11165	COG0596	Alpha beta hydrolase
GPY12_RS11180	COG1346	cytolysis
GPY12_RS11190	COG0583	DNA-binding transcription factor activity
GPY12_RS11200	COG0735	belongs to the Fur family
GPY12_RS11205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY12_RS11210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY12_RS11215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY12_RS11220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY12_RS11220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY12_RS11225	COG0431	NADPH-dependent FMN reductase
GPY12_RS11235	COG3101	peptidyl-lysine hydroxylation
GPY12_RS11240	COG2860	membrane
GPY12_RS11245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY12_RS11250	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY12_RS11270	COG1987	bacterial-type flagellum assembly
GPY12_RS11315	COG1317	bacterial-type flagellum organization
GPY12_RS11320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY12_RS11340	COG4191	Histidine kinase
GPY12_RS11345	COG2204	response regulator
GPY12_RS11350	COG1516	flagellar protein fliS
GPY12_RS11360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY12_RS11365	COG1334	flagellar protein FlaG
GPY12_RS11370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY12_RS11375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY12_RS11380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY12_RS11385	COG2837	iron assimilation
GPY12_RS11405	COG1393	Belongs to the ArsC family
GPY12_RS11410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY12_RS11415	COG1876	peptidase activity
GPY12_RS11425	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY12_RS11430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY12_RS11440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY12_RS11460	COG4783	chaperone-mediated protein folding
GPY12_RS11465	COG1393	Belongs to the ArsC family
GPY12_RS11485	COG2233	PERMEase
GPY12_RS11490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY12_RS11495	COG0737	Belongs to the 5'-nucleotidase family
GPY12_RS11500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY12_RS11505	COG2912	Transglutaminase-like superfamily
GPY12_RS11510	COG3094	Invasion gene expression up-regulator, SirB
GPY12_RS11515	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY12_RS11520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY12_RS11525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY12_RS11530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY12_RS11535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY12_RS11540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY12_RS11545	COG0193	aminoacyl-tRNA hydrolase activity
GPY12_RS11550	COG0012	GTP binding
GPY12_RS11635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY12_RS11640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY12_RS11655	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY12_RS11655	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY12_RS11660	COG1706	bacterial-type flagellum-dependent cell motility
GPY12_RS11665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY12_RS11670	COG4786	Flagellar basal body rod
GPY12_RS11675	COG4787	bacterial-type flagellum-dependent cell motility
GPY12_RS11680	COG1749	Flagellar hook protein flgE
GPY12_RS11685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY12_RS11690	COG1558	bacterial-type flagellum-dependent cell motility
GPY12_RS11695	COG1815	bacterial-type flagellum-dependent cell motility
GPY12_RS11700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY12_RS11705	COG0784	Response regulator, receiver
GPY12_RS11705	COG0835	chemotaxis
GPY12_RS11755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY12_RS11760	COG2608	mercury ion transmembrane transporter activity
GPY12_RS11760	COG2217	Heavy metal translocating P-type atpase
GPY12_RS11790	COG2840	Smr protein MutS2
GPY12_RS11795	COG1187	pseudouridine synthase activity
GPY12_RS11800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY12_RS11805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY12_RS11810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY12_RS11815	COG0121	glutamine amidotransferase
GPY12_RS11820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY12_RS11825	COG1960	acyl-CoA dehydrogenase activity
GPY12_RS11835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY12_RS11840	COG0328	RNA-DNA hybrid ribonuclease activity
GPY12_RS11845	COG2226	methyltransferase
GPY12_RS11850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY12_RS11855	COG1388	LysM domain
GPY12_RS11855	COG0741	lytic transglycosylase activity
GPY12_RS11865	COG0347	Belongs to the P(II) protein family
GPY12_RS11875	COG0037	tRNA processing
GPY12_RS11880	COG0825	malonyl-CoA metabolic process
GPY12_RS11885	COG0587	DNA-directed DNA polymerase activity
GPY12_RS11890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY12_RS11895	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY12_RS11900	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY12_RS11905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY12_RS11910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY12_RS11915	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY12_RS11925	COG0750	zinc metalloprotease
GPY12_RS11930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY12_RS11935	COG0575	Belongs to the CDS family
GPY12_RS11940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY12_RS11945	COG0233	cytoplasmic translational termination
GPY12_RS11950	COG0528	UMP kinase activity
GPY12_RS11955	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY12_RS11960	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY12_RS11965	COG0024	Methionine aminopeptidase
GPY12_RS11970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY12_RS11980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY12_RS11985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY12_RS11990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY12_RS11995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPY12_RS12010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY12_RS12010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY12_RS12015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY12_RS12020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY12_RS12025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY12_RS12040	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY12_RS12045	COG2252	PERMEase
GPY12_RS12050	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY12_RS12055	COG0189	ligase activity
GPY12_RS12055	COG4067	protein conserved in archaea
GPY12_RS12060	COG0189	ligase activity
GPY12_RS12070	COG0733	neurotransmitter:sodium symporter activity
GPY12_RS12075	COG3706	GGDEF domain
GPY12_RS12075	COG4251	negative regulation of phosphorylation
GPY12_RS12075	COG5001	Diguanylate cyclase
GPY12_RS12075	COG2203	Gaf domain
GPY12_RS12085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY12_RS12095	COG1477	protein flavinylation
GPY12_RS12100	COG2871	sodium ion transport
GPY12_RS12105	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY12_RS12110	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY12_RS12115	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY12_RS12120	COG1805	sodium ion transport
GPY12_RS12125	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY12_RS12130	COG0271	Belongs to the BolA IbaG family
GPY12_RS12135	COG2813	Specifically methylates the guanine in position
GPY12_RS12145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY12_RS12150	COG2211	Major facilitator Superfamily
GPY12_RS12160	COG1595	DNA-templated transcription, initiation
GPY12_RS12175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY12_RS12180	COG0693	protein deglycase activity
GPY12_RS12185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY12_RS12190	COG2166	iron-sulfur cluster assembly
GPY12_RS12195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY12_RS12210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY12_RS12210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY12_RS12220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY12_RS12225	COG1074	ATP-dependent DNA helicase activity
GPY12_RS12230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY12_RS12245	COG3141	response to X-ray
GPY12_RS12250	COG2171	N-acyltransferase activity
GPY12_RS12265	COG0189	ligase activity
GPY12_RS12265	COG0569	domain protein
GPY12_RS12280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY12_RS12285	COG1609	Transcriptional regulator
GPY12_RS12290	COG3250	beta-galactosidase activity
GPY12_RS12305	COG1022	Amp-dependent synthetase and ligase
GPY12_RS12315	COG0583	DNA-binding transcription factor activity
GPY12_RS12320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY12_RS12325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY12_RS12335	COG0560	Phosphoserine phosphatase
GPY12_RS12345	COG0813	purine-nucleoside phosphorylase activity
GPY12_RS12350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY12_RS12355	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY12_RS12360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY12_RS12370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY12_RS12375	COG0084	hydrolase, TatD family'
GPY12_RS12390	COG1115	amino acid carrier protein
GPY12_RS12400	COG2801	Transposase and inactivated derivatives
GPY12_RS12410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY12_RS12415	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY12_RS12420	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY12_RS12425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY12_RS12430	COG0083	homoserine kinase activity
GPY12_RS12450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY12_RS12460	COG0745	RESPONSE REGULATOR receiver
GPY12_RS12465	COG2198	Histidine kinase
GPY12_RS12465	COG5002	protein histidine kinase activity
GPY12_RS12465	COG0784	Response regulator, receiver
GPY12_RS12470	COG2203	Gaf domain
GPY12_RS12470	COG3706	GGDEF domain
GPY12_RS12470	COG5001	Diguanylate cyclase
GPY12_RS12470	COG4251	negative regulation of phosphorylation
GPY12_RS12475	COG1242	4 iron, 4 sulfur cluster binding
GPY12_RS12480	COG0070	glutamate synthase
GPY12_RS12480	COG0069	glutamate synthase activity
GPY12_RS12480	COG0067	glutamate synthase
GPY12_RS12490	COG0067	glutamate synthase
GPY12_RS12490	COG0069	glutamate synthase activity
GPY12_RS12490	COG0070	glutamate synthase
GPY12_RS12495	COG0493	'glutamate synthase
GPY12_RS12505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY12_RS12515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY12_RS12520	COG2860	membrane
GPY12_RS12525	COG0583	DNA-binding transcription factor activity
GPY12_RS12530	COG0730	response to heat
GPY12_RS12535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY12_RS12540	COG0505	Belongs to the CarA family
GPY12_RS12545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY12_RS12550	COG0494	nUDIX hydrolase
GPY12_RS12555	COG0653	protein targeting
GPY12_RS12565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY12_RS12570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY12_RS12575	COG0849	cell division
GPY12_RS12580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY12_RS12585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY12_RS12590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY12_RS12595	COG0772	Belongs to the SEDS family
GPY12_RS12600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY12_RS12605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY12_RS12610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY12_RS12615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY12_RS12620	COG0768	penicillin binding
GPY12_RS12625	COG3116	cell division
GPY12_RS12630	COG0275	rRNA processing
GPY12_RS12640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY12_RS12645	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY12_RS12650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY12_RS12655	COG2186	Transcriptional regulator
GPY12_RS12660	COG0737	Belongs to the 5'-nucleotidase family
GPY12_RS12665	COG1227	inorganic diphosphatase activity
GPY12_RS12670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY12_RS12675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY12_RS12680	COG4974	Belongs to the 'phage' integrase family
GPY12_RS12685	COG0716	FMN binding
GPY12_RS12705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY12_RS12710	COG1459	type II secretion system
GPY12_RS12720	COG0237	dephospho-CoA kinase activity
GPY12_RS12725	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY12_RS12730	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY12_RS12735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY12_RS12740	COG0187	DNA topoisomerase II activity
GPY12_RS12745	COG3150	esterase
GPY12_RS12755	COG3151	Protein conserved in bacteria
GPY12_RS12760	COG0494	nUDIX hydrolase
GPY12_RS12765	COG1538	Outer membrane efflux protein
GPY12_RS12775	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY12_RS12785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY12_RS12790	COG3025	triphosphatase activity
GPY12_RS12795	COG1392	Phosphate transport regulator
GPY12_RS12800	COG0306	phosphate transporter
GPY12_RS12805	COG4991	sh3 domain protein
GPY12_RS12815	COG3409	Peptidoglycan-binding domain 1 protein
GPY12_RS12815	COG3267	Type II secretory pathway component ExeA
GPY12_RS12820	COG0617	tRNA 3'-terminal CCA addition
GPY12_RS12830	COG0814	amino acid
GPY12_RS12840	COG0148	phosphopyruvate hydratase activity
GPY12_RS12845	COG0504	CTP synthase activity
GPY12_RS12850	COG3956	TIGRFAM MazG family protein
GPY12_RS12855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY12_RS12860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY12_RS12865	COG2205	protein histidine kinase activity
GPY12_RS12865	COG4999	Histidine kinase
GPY12_RS12865	COG3850	Histidine kinase
GPY12_RS12865	COG3437	response regulator, receiver
GPY12_RS12870	COG5001	Diguanylate cyclase
GPY12_RS12885	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY12_RS12890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY12_RS12895	COG1381	Involved in DNA repair and RecF pathway recombination
GPY12_RS12900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY12_RS12905	COG0571	ribonuclease III activity
GPY12_RS12910	COG0681	Belongs to the peptidase S26 family
GPY12_RS12915	COG0481	GTPase activity
GPY12_RS12920	COG3086	response to oxidative stress
GPY12_RS12935	COG1595	DNA-templated transcription, initiation
GPY12_RS12940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY12_RS12950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY12_RS12955	COG0354	folic acid binding
GPY12_RS12965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY12_RS12970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY12_RS12975	COG3079	Belongs to the UPF0149 family
GPY12_RS12980	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY12_RS12990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY12_RS12995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY12_RS13000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY12_RS13005	COG0440	acetolactate synthase activity
GPY12_RS13010	COG0028	Belongs to the TPP enzyme family
GPY12_RS13015	COG1022	Amp-dependent synthetase and ligase
GPY12_RS13020	COG0583	DNA-binding transcription factor activity
GPY12_RS13030	COG0671	phosphoesterase, PA-phosphatase related
GPY12_RS13040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY12_RS13045	COG0473	3-isopropylmalate dehydrogenase activity
GPY12_RS13050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY12_RS13055	COG0066	3-isopropylmalate dehydratase activity
GPY12_RS13095	COG3437	response regulator, receiver
GPY12_RS13110	COG0795	lipopolysaccharide-transporting ATPase activity
GPY12_RS13115	COG0795	lipopolysaccharide-transporting ATPase activity
GPY12_RS13120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY12_RS13125	COG2927	DNA polymerase III (CHI subunit)
GPY12_RS13130	COG0525	valine-tRNA ligase activity
GPY12_RS13140	COG4269	membrane
GPY12_RS13145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY12_RS13150	COG0564	pseudouridine synthase activity
GPY12_RS13155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY12_RS13160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY12_RS13165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY12_RS13170	COG0540	Belongs to the ATCase OTCase family
GPY12_RS13175	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY12_RS13180	COG0251	oxidation-reduction process
GPY12_RS13185	COG0204	Acyl-transferase
GPY12_RS13190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY12_RS13195	COG5007	Belongs to the BolA IbaG family
GPY12_RS13205	COG2854	intermembrane phospholipid transfer
GPY12_RS13210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY12_RS13215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY12_RS13220	COG1127	ABC transporter
GPY12_RS13230	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY12_RS13230	COG0517	IMP dehydrogenase activity
GPY12_RS13245	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY12_RS13250	COG1137	ATPase activity
GPY12_RS13260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY12_RS13265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS13275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS13280	COG2239	Acts as a magnesium transporter
GPY12_RS13285	COG0312	modulator of DNA gyrase
GPY12_RS13290	COG3028	Belongs to the UPF0307 family
GPY12_RS13295	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY12_RS13300	COG1178	ABC-type Fe3 transport system permease component
GPY12_RS13305	COG4143	(ABC) transporter
GPY12_RS13310	COG0163	prenyltransferase activity
GPY12_RS13315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY12_RS13320	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY12_RS13325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY12_RS13335	COG2105	PFAM AIG2 family protein
GPY12_RS13340	COG2911	Protein conserved in bacteria
GPY12_RS13345	COG0729	surface antigen
GPY12_RS13350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY12_RS13355	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY12_RS13370	COG1136	(ABC) transporter
GPY12_RS13390	COG0529	Catalyzes the synthesis of activated sulfate
GPY12_RS13395	COG2895	sulfate adenylyltransferase (ATP) activity
GPY12_RS13400	COG0175	sulfate reduction
GPY12_RS13405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY12_RS13405	COG1648	precorrin-2 dehydrogenase activity
GPY12_RS13410	COG0737	Belongs to the 5'-nucleotidase family
GPY12_RS13420	COG0513	Belongs to the DEAD box helicase family
GPY12_RS13425	COG2153	protein acetylation
GPY12_RS13430	COG0697	spore germination
GPY12_RS13435	COG3266	domain, Protein
GPY12_RS13435	COG3061	Opacity-associated protein A
GPY12_RS13440	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY12_RS13450	COG0203	ribosomal protein L17
GPY12_RS13455	COG0202	RNA polymerase activity
GPY12_RS13460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY12_RS13465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY12_RS13470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY12_RS13480	COG0201	protein transport
GPY12_RS13485	COG0200	Binds to the 23S rRNA
GPY12_RS13490	COG1841	ribosomal large subunit assembly
GPY12_RS13495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPY12_RS13500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY12_RS13505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY12_RS13510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY12_RS13515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY12_RS13520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY12_RS13525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY12_RS13530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY12_RS13540	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY12_RS13545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPY12_RS13550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY12_RS13555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY12_RS13560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY12_RS13565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY12_RS13570	COG0089	rRNA binding
GPY12_RS13575	COG0088	Forms part of the polypeptide exit tunnel
GPY12_RS13580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY12_RS13585	COG0051	transcription antitermination factor activity, RNA binding
GPY12_RS13590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY12_RS13595	COG0557	exoribonuclease II activity
GPY12_RS13600	COG3083	sulfuric ester hydrolase activity
GPY12_RS13605	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY12_RS13610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY12_RS13620	COG1047	Peptidyl-prolyl cis-trans
GPY12_RS13635	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY12_RS13640	COG0488	(ABC) transporter
GPY12_RS13650	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY12_RS13660	COG3954	Phosphoribulokinase
GPY12_RS13665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY12_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
GPY12_RS13685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY12_RS13695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY12_RS13710	COG0180	Tryptophanyl-tRNA synthetase
GPY12_RS13715	COG0546	phosphoglycolate phosphatase activity
GPY12_RS13720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY12_RS13725	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY12_RS13735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY12_RS13740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY12_RS13770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY12_RS13780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY12_RS13780	COG0678	peroxiredoxin activity
GPY12_RS13785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY12_RS13795	COG0165	Argininosuccinate lyase
GPY12_RS13800	COG0137	argininosuccinate synthase activity
GPY12_RS13805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY12_RS13810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY12_RS13815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY12_RS13820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY12_RS13830	COG1045	serine acetyltransferase
GPY12_RS13835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY12_RS13840	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY12_RS13845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY12_RS13850	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY12_RS13855	COG1053	succinate dehydrogenase
GPY12_RS13860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY12_RS13865	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY12_RS13870	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY12_RS13875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY12_RS13880	COG1509	lysine 2,3-aminomutase activity
GPY12_RS13895	COG3344	reverse transcriptase
GPY12_RS13900	COG0459	protein refolding
GPY12_RS13905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY12_RS13930	COG0149	triose-phosphate isomerase activity
GPY12_RS13940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY12_RS13945	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY12_RS13950	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY12_RS13955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY12_RS13965	COG1609	Transcriptional regulator
GPY12_RS13970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY12_RS13975	COG0254	rRNA binding
GPY12_RS13980	COG0281	malic enzyme
GPY12_RS13985	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPY12_RS13990	COG0626	cystathionine gamma-synthase activity
GPY12_RS13995	COG0527	aspartate kinase activity
GPY12_RS13995	COG0460	homoserine dehydrogenase
GPY12_RS14000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY12_RS14005	COG3074	FtsZ-dependent cytokinesis
GPY12_RS14010	COG1494	fructose-1,6-bisphosphatase
GPY12_RS14015	COG0205	6-phosphofructokinase activity
GPY12_RS14020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY12_RS14030	COG0745	RESPONSE REGULATOR receiver
GPY12_RS14035	COG2205	protein histidine kinase activity
GPY12_RS14045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY12_RS14055	COG1027	Aspartate ammonia-lyase
GPY12_RS14060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY12_RS14065	COG4232	protein-disulfide reductase activity
GPY12_RS14075	COG3263	regulation of cellular component size
GPY12_RS14085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY12_RS14090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY12_RS14095	COG0194	GDP metabolic process
GPY12_RS14100	COG1758	RNA polymerase activity
GPY12_RS14105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY12_RS14110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY12_RS14115	COG2233	PERMEase
GPY12_RS14125	COG0745	RESPONSE REGULATOR receiver
GPY12_RS14130	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY12_RS14135	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY12_RS14140	COG1129	ABC transporter
GPY12_RS14155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY12_RS14160	COG2183	response to ionizing radiation
GPY12_RS14170	COG0596	Alpha beta hydrolase
GPY12_RS14180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY12_RS14180	COG0316	Belongs to the HesB IscA family
GPY12_RS14185	COG0494	nUDIX hydrolase
GPY12_RS14190	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY12_RS14200	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY12_RS14205	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY12_RS14210	COG3156	type II secretion system protein K
GPY12_RS14215	COG4795	General secretion pathway protein
GPY12_RS14220	COG2165	general secretion pathway protein
GPY12_RS14225	COG2165	general secretion pathway protein
GPY12_RS14230	COG2165	general secretion pathway protein
GPY12_RS14235	COG1459	type II secretion system
GPY12_RS14240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY12_RS14250	COG3031	protein transport across the cell outer membrane
GPY12_RS14255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY12_RS14260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY12_RS14265	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY12_RS14275	COG0456	acetyltransferase
GPY12_RS14280	COG1490	D-aminoacyl-tRNA deacylase activity
GPY12_RS14305	COG0174	glutamine synthetase
GPY12_RS14315	COG3852	Histidine kinase
GPY12_RS14325	COG5001	Diguanylate cyclase
GPY12_RS14325	COG3300	MHYT domain
GPY12_RS14330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY12_RS14405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY12_RS14415	COG4206	TonB-dependent receptor
GPY12_RS14420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY12_RS14435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY12_RS14440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY12_RS14445	COG2177	Part of the ABC transporter FtsEX involved in
GPY12_RS14450	COG2884	Cell division ATP-binding protein ftsE
GPY12_RS14455	COG0552	protein localization to endoplasmic reticulum
GPY12_RS14460	COG0742	ribosomal rna small subunit methyltransferase
GPY12_RS14490	COG0783	Belongs to the Dps family
GPY12_RS14495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY12_RS14500	COG1280	lysine exporter protein (LysE YggA)
GPY12_RS14505	COG2267	carboxylic ester hydrolase activity
GPY12_RS14510	COG0561	phosphatase activity
GPY12_RS14525	COG2199	diguanylate cyclase activity
GPY12_RS14525	COG2200	EAL domain
GPY12_RS14525	COG3287	FIST C domain
GPY12_RS14530	COG1011	Hydrolase
GPY12_RS14535	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY12_RS14545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY12_RS14550	COG0019	diaminopimelate decarboxylase activity
GPY12_RS14560	COG1965	Belongs to the frataxin family
GPY12_RS14565	COG3072	Adenylate cyclase
GPY12_RS14575	COG0181	hydroxymethylbilane synthase activity
GPY12_RS14580	COG1587	Uroporphyrinogen-III synthase
GPY12_RS14585	COG2959	enzyme of heme biosynthesis
GPY12_RS14590	COG3071	HemY protein
GPY12_RS14595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY12_RS14605	COG3078	GTPase activator activity
GPY12_RS14610	COG3272	Protein of unknown function (DUF1722)
GPY12_RS14615	COG0813	purine-nucleoside phosphorylase activity
GPY12_RS14630	COG3706	GGDEF domain
GPY12_RS14640	COG1566	PFAM secretion protein HlyD family protein
GPY12_RS14655	COG3655	Transcriptional regulator
GPY12_RS14670	COG0786	glutamate:sodium symporter activity
GPY12_RS14685	COG1999	signal sequence binding
GPY12_RS14690	COG2847	Copper chaperone PCu(A)C
GPY12_RS14695	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY12_RS14705	COG0671	phosphoesterase, PA-phosphatase related
GPY12_RS14735	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY12_RS14740	COG0471	metal ion transport
GPY12_RS14775	COG3501	Rhs element vgr protein
GPY12_RS14785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY12_RS14790	COG1640	4-alpha-glucanotransferase
GPY12_RS14795	COG0058	SHG alpha-glucan phosphorylase activity
GPY12_RS14800	COG2909	trisaccharide binding
GPY12_RS14815	COG2084	Dehydrogenase
GPY12_RS14820	COG0217	transcriptional regulatory protein
GPY12_RS14855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY12_RS14860	COG1444	tRNA N-acetyltransferase activity
GPY12_RS14880	COG1028	Short-chain dehydrogenase reductase Sdr
GPY12_RS14890	COG0745	RESPONSE REGULATOR receiver
GPY12_RS14895	COG0642	Histidine kinase
GPY12_RS14900	COG2194	sulfuric ester hydrolase activity
GPY12_RS14910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY12_RS14915	COG0601	transmembrane transport
GPY12_RS14920	COG0747	negative chemotaxis
GPY12_RS14930	COG0745	RESPONSE REGULATOR receiver
GPY12_RS14935	COG0643	Histidine kinase
GPY12_RS14935	COG2198	Histidine kinase
GPY12_RS14940	COG0835	chemotaxis
GPY12_RS14945	COG0835	chemotaxis
GPY12_RS14950	COG0840	transmembrane signaling receptor activity
GPY12_RS14955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY12_RS14960	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPY12_RS14980	COG0745	RESPONSE REGULATOR receiver
GPY12_RS14980	COG3706	GGDEF domain
GPY12_RS15010	COG0259	pyridoxamine-phosphate oxidase activity
GPY12_RS15020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY12_RS15045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY12_RS15085	COG2197	response regulator
GPY12_RS15095	COG1982	Orn Lys Arg decarboxylase major
GPY12_RS15100	COG0531	amino acid
GPY12_RS15105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY12_RS15115	COG1901	pseudouridine methyltransferase
GPY12_RS15130	COG4221	oxidoreductase activity
GPY12_RS15145	COG2910	NAD(P)H-binding
GPY12_RS15150	COG0697	spore germination
GPY12_RS15165	COG0655	NAD(P)H dehydrogenase (quinone) activity
GPY12_RS15170	COG0583	DNA-binding transcription factor activity
GPY12_RS15185	COG0697	spore germination
GPY12_RS15215	COG0673	inositol 2-dehydrogenase activity
GPY12_RS15220	COG3722	fumarate hydratase activity
GPY12_RS15225	COG0246	Mannitol dehydrogenase
GPY12_RS15230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS15230	COG2213	PTS system mannitol-specific
GPY12_RS15235	COG0739	heme binding
GPY12_RS15245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY12_RS15250	COG4597	amino acid ABC transporter
GPY12_RS15255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY12_RS15265	COG1126	abc transporter atp-binding protein
GPY12_RS15270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY12_RS15275	COG0534	Mate efflux family protein
GPY12_RS15280	COG0840	transmembrane signaling receptor activity
GPY12_RS15285	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY12_RS15290	COG1366	Belongs to the anti-sigma-factor antagonist family
GPY12_RS15300	COG2172	sigma factor antagonist activity
GPY12_RS15315	COG3437	response regulator, receiver
GPY12_RS15325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY12_RS15335	COG1304	FMN binding
GPY12_RS15340	COG1620	l-lactate permease
GPY12_RS15345	COG0583	DNA-binding transcription factor activity
GPY12_RS15350	COG4172	Belongs to the ABC transporter superfamily
GPY12_RS15360	COG1067	ATP-dependent peptidase activity
GPY12_RS15370	COG2211	Major facilitator Superfamily
GPY12_RS15380	COG3123	guanosine phosphorylase activity
GPY12_RS15385	COG1741	Belongs to the pirin family
GPY12_RS15395	COG5001	Diguanylate cyclase
GPY12_RS15400	COG0583	DNA-binding transcription factor activity
GPY12_RS15435	COG3706	GGDEF domain
GPY12_RS15440	COG1846	Transcriptional regulator
GPY12_RS15445	COG0784	Response regulator, receiver
GPY12_RS15445	COG0835	chemotaxis
GPY12_RS15450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY12_RS15465	COG0583	DNA-binding transcription factor activity
GPY12_RS15475	COG2197	response regulator
GPY12_RS15480	COG0393	Putative heavy-metal-binding
GPY12_RS15495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY12_RS15500	COG3842	ATPase activity
GPY12_RS15510	COG1175	transmembrane transport
GPY12_RS15515	COG3833	ABC-type maltose transport systems, permease component
GPY12_RS15530	COG0737	Belongs to the 5'-nucleotidase family
GPY12_RS15540	COG1349	DNA-binding transcription factor activity
GPY12_RS15570	COG1278	Cold shock
GPY12_RS15575	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY12_RS15585	COG0488	(ABC) transporter
GPY12_RS15590	COG2354	Protein conserved in bacteria
GPY12_RS15595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY12_RS15605	COG3152	Membrane
GPY12_RS15615	COG0418	dihydroorotase activity
GPY12_RS15620	COG3217	Mosc domain protein beta barrel domain protein
GPY12_RS15620	COG0633	Ferredoxin
GPY12_RS15620	COG3217	Mosc domain protein beta barrel domain protein
GPY12_RS15620	COG0633	Ferredoxin
GPY12_RS15655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY12_RS15660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY12_RS15665	COG4558	Periplasmic binding protein
GPY12_RS15670	COG0848	biopolymer transport protein
GPY12_RS15675	COG0811	peptide transport
GPY12_RS15680	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY12_RS15690	COG3721	Heme iron utilization protein
GPY12_RS15695	COG0748	coenzyme F420 binding
GPY12_RS15705	COG1858	cytochrome C peroxidase
GPY12_RS15710	COG3835	regulator
GPY12_RS15715	COG2610	gluconate transmembrane transporter activity
GPY12_RS15720	COG1929	Belongs to the glycerate kinase type-1 family
GPY12_RS15740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY12_RS15745	COG0363	glucosamine-6-phosphate deaminase activity
GPY12_RS15750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY12_RS15755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY12_RS15770	COG3706	GGDEF domain
GPY12_RS15770	COG5001	Diguanylate cyclase
GPY12_RS15770	COG4251	negative regulation of phosphorylation
GPY12_RS15770	COG2203	Gaf domain
GPY12_RS15785	COG0346	lactoylglutathione lyase activity
GPY12_RS15795	COG2873	o-acetylhomoserine
GPY12_RS15800	COG0156	8-amino-7-oxononanoate synthase activity
GPY12_RS15805	COG1063	alcohol dehydrogenase
GPY12_RS15815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY12_RS15820	COG2814	Major facilitator Superfamily
GPY12_RS15835	COG0641	radical SAM
GPY12_RS15840	COG0583	DNA-binding transcription factor activity
GPY12_RS15845	COG1686	Belongs to the peptidase S11 family
GPY12_RS15855	COG3047	cAMP biosynthetic process
GPY12_RS15860	COG3227	Zinc metalloprotease (Elastase)
GPY12_RS15875	COG2267	carboxylic ester hydrolase activity
GPY12_RS15880	COG2067	long-chain fatty acid transport protein
GPY12_RS15885	COG0366	Alpha amylase catalytic
GPY12_RS15890	COG4989	oxidoreductase activity
GPY12_RS15900	COG1136	(ABC) transporter
GPY12_RS15905	COG0577	efflux transmembrane transporter activity
GPY12_RS15905	COG1136	(ABC) transporter
GPY12_RS15920	COG3275	phosphorelay sensor kinase activity
GPY12_RS15925	COG3279	Response regulator of the LytR AlgR family
GPY12_RS15935	COG3706	GGDEF domain
GPY12_RS15940	COG0531	amino acid
GPY12_RS15960	COG5001	Diguanylate cyclase
GPY12_RS15970	COG1765	OsmC-like protein
GPY12_RS15975	COG1253	flavin adenine dinucleotide binding
GPY12_RS15980	COG2171	N-acyltransferase activity
GPY12_RS15990	COG2264	protein methyltransferase activity
GPY12_RS16005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY12_RS16010	COG3186	Phenylalanine-4-hydroxylase
GPY12_RS16015	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY12_RS16025	COG0534	Mate efflux family protein
GPY12_RS16040	COG0456	acetyltransferase
GPY12_RS16045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY12_RS16050	COG0662	Cupin 2, conserved barrel domain protein
GPY12_RS16055	COG0527	aspartate kinase activity
GPY12_RS16060	COG2239	Acts as a magnesium transporter
GPY12_RS16085	COG1166	arginine decarboxylase activity
GPY12_RS16105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY12_RS16110	COG0800	Aldolase
GPY12_RS16115	COG1085	galactose-1-phosphate uridylyltransferase
GPY12_RS16120	COG1028	Short-chain dehydrogenase reductase Sdr
GPY12_RS16145	COG3119	arylsulfatase activity
GPY12_RS16150	COG3119	arylsulfatase activity
GPY12_RS16155	COG0641	radical SAM
GPY12_RS16170	COG0601	transmembrane transport
GPY12_RS16175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY12_RS16190	COG1414	Transcriptional regulator
GPY12_RS16195	COG1686	Belongs to the peptidase S11 family
GPY12_RS16210	COG3338	carbonate dehydratase activity
GPY12_RS16215	COG2755	lipolytic protein G-D-S-L family
GPY12_RS16220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY12_RS16220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY12_RS16230	COG0509	glycine decarboxylation via glycine cleavage system
GPY12_RS16235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY12_RS16250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY12_RS16260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY12_RS16265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPY12_RS16290	COG2856	Zn peptidase
GPY12_RS16375	COG0300	oxidoreductase activity
GPY12_RS16410	COG3328	transposase activity
GPY12_RS16545	COG0110	maltose O-acetyltransferase activity
GPY12_RS16575	COG4628	conserved protein (DUF2132)
GPY12_RS16615	COG1418	mRNA catabolic process
GPY12_RS16780	COG0456	acetyltransferase
GPY12_RS16795	COG0456	acetyltransferase
GPY12_RS16850	COG1942	4-Oxalocrotonate Tautomerase
GPY12_RS16950	COG3738	Protein conserved in bacteria
GPY12_RS17005	COG0384	phenazine biosynthesis protein PhzF
GPY12_RS17070	COG1942	4-Oxalocrotonate Tautomerase
GPY12_RS17090	COG0776	regulation of translation
GPY12_RS17225	COG0110	maltose O-acetyltransferase activity
GPY12_RS17230	COG1280	lysine exporter protein (LysE YggA)
GPY12_RS17320	COG2801	Transposase and inactivated derivatives
GPY12_RS17510	COG0456	acetyltransferase
GPY12_RS17590	COG1943	Transposase
GPY12_RS17600	COG2814	Major facilitator Superfamily
GPY12_RS17620	COG0583	DNA-binding transcription factor activity
GPY12_RS17625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GPY12_RS17635	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GPY12_RS17660	COG4977	sequence-specific DNA binding
GPY12_RS17660	COG1917	Cupin 2, conserved barrel domain protein
GPY12_RS17670	COG1328	CTP reductase activity
GPY12_RS17675	COG0602	queuosine metabolic process
GPY12_RS17685	COG4067	protein conserved in archaea
GPY12_RS17685	COG0189	ligase activity
GPY12_RS17690	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY12_RS17695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY12_RS17695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY12_RS17695	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY12_RS17700	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY12_RS17705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS17705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS17710	COG1609	Transcriptional regulator
GPY12_RS17715	COG0420	3'-5' exonuclease activity
GPY12_RS17720	COG0419	ATPase involved in DNA repair
GPY12_RS17725	COG2205	protein histidine kinase activity
GPY12_RS17725	COG0784	Response regulator, receiver
GPY12_RS17730	COG0156	8-amino-7-oxononanoate synthase activity
GPY12_RS17740	COG0038	chloride channel
GPY12_RS17745	COG0523	cobalamin synthesis protein
GPY12_RS17755	COG4409	exo-alpha-(2->6)-sialidase activity
GPY12_RS17760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY12_RS17765	COG1940	carbohydrate kinase activity
GPY12_RS17770	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPY12_RS17780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY12_RS17785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY12_RS17790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY12_RS17795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY12_RS17800	COG1737	Transcriptional regulator
GPY12_RS17805	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY12_RS17810	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY12_RS17845	COG3038	cytochrome b561
GPY12_RS17855	COG2116	formate transmembrane transporter activity
GPY12_RS17860	COG0583	DNA-binding transcription factor activity
GPY12_RS17870	COG3593	DNA synthesis involved in DNA repair
GPY12_RS17875	COG0737	Belongs to the 5'-nucleotidase family
GPY12_RS17890	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY12_RS17925	COG3706	GGDEF domain
GPY12_RS17935	COG1309	transcriptional regulator
GPY12_RS17955	COG3706	GGDEF domain
GPY12_RS17970	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY12_RS17975	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY12_RS18185	COG0023	Translation Initiation Factor
GPY12_RS18195	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY12_RS18205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY12_RS18205	COG1042	CoA-binding domain protein
GPY12_RS18205	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY12_RS18210	COG0583	DNA-binding transcription factor activity
GPY12_RS18215	COG4771	TonB-dependent receptor
GPY12_RS18230	COG2050	protein possibly involved in aromatic compounds catabolism
GPY12_RS18250	COG0625	glutathione transferase activity
GPY12_RS18265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY12_RS18275	COG4172	Belongs to the ABC transporter superfamily
GPY12_RS18280	COG4239	(ABC) transporter, permease
GPY12_RS18285	COG4174	ABC transporter (Permease)
GPY12_RS18290	COG4166	transmembrane transport
GPY12_RS18305	COG3042	response to heat
GPY12_RS18335	COG3842	ATPase activity
GPY12_RS18340	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY12_RS18345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY12_RS18355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY12_RS18360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY12_RS18365	COG1011	Hydrolase
GPY12_RS18375	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY12_RS18380	COG1454	alcohol dehydrogenase
GPY12_RS18385	COG1970	mechanosensitive ion channel activity
GPY12_RS18390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY12_RS18395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY12_RS18395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY12_RS18400	COG0302	gtp cyclohydrolase
GPY12_RS18410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY12_RS18420	COG2897	thiosulfate sulfurtransferase activity
GPY12_RS18430	COG2390	Transcriptional regulator
GPY12_RS18435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY12_RS18440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY12_RS18450	COG0798	PFAM Bile acid sodium symporter
GPY12_RS18455	COG0640	Transcriptional regulator
GPY12_RS18485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY12_RS18520	COG0583	DNA-binding transcription factor activity
GPY12_RS18575	COG1566	PFAM secretion protein HlyD family protein
GPY12_RS18660	COG1999	signal sequence binding
GPY12_RS18665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY12_RS18675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY12_RS18690	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY12_RS18700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY12_RS18705	COG0840	transmembrane signaling receptor activity
GPY12_RS18710	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY12_RS18715	COG1760	l-serine dehydratase
GPY12_RS18720	COG2197	response regulator
GPY12_RS18725	COG3850	Histidine kinase
GPY12_RS18730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY12_RS18740	COG0243	molybdopterin cofactor binding
GPY12_RS18750	COG3005	denitrification pathway
GPY12_RS18760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY12_RS18765	COG2197	response regulator
GPY12_RS18770	COG3851	Histidine kinase
GPY12_RS18775	COG2271	Major facilitator Superfamily
GPY12_RS18780	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY12_RS18790	COG3842	ATPase activity
GPY12_RS18845	COG4964	Belongs to the GSP D family
GPY12_RS18865	COG0583	DNA-binding transcription factor activity
GPY12_RS18875	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY12_RS18885	COG0183	Belongs to the thiolase family
GPY12_RS18905	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY12_RS18910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY12_RS18920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY12_RS18925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY12_RS18940	COG3706	GGDEF domain
GPY12_RS18945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY12_RS18955	COG1979	alcohol dehydrogenase
GPY12_RS18970	COG4191	Histidine kinase
GPY12_RS18975	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY12_RS18980	COG2271	Major facilitator Superfamily
GPY12_RS18985	COG0469	pyruvate kinase activity
GPY12_RS18990	COG2198	Histidine kinase
GPY12_RS18990	COG2205	protein histidine kinase activity
GPY12_RS18990	COG0784	Response regulator, receiver
GPY12_RS18995	COG1879	ABC-type sugar transport system periplasmic component
GPY12_RS19000	COG1803	Methylglyoxal synthase
GPY12_RS19005	COG1335	isochorismatase
GPY12_RS19015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY12_RS19035	COG0210	DNA helicase
GPY12_RS19040	COG1289	transmembrane transporter activity
GPY12_RS19060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY12_RS19065	COG4149	molybdate abc transporter
GPY12_RS19070	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY12_RS19075	COG1492	cobalamin metabolic process
GPY12_RS19095	COG0784	Response regulator, receiver
GPY12_RS19095	COG5002	protein histidine kinase activity
GPY12_RS19100	COG1879	ABC-type sugar transport system periplasmic component
GPY12_RS19110	COG2827	Endonuclease containing a URI domain
GPY12_RS19115	COG3132	Protein of unknown function, DUF480
GPY12_RS19135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY12_RS19140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY12_RS19145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY12_RS19150	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY12_RS19155	COG0247	lactate metabolic process
GPY12_RS19165	COG1215	transferase activity, transferring glycosyl groups
GPY12_RS19175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY12_RS19180	COG3118	belongs to the thioredoxin family
GPY12_RS19215	COG0583	DNA-binding transcription factor activity
GPY12_RS19225	COG4160	amino acid transport
GPY12_RS19230	COG4215	(ABC) transporter
GPY12_RS19235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY12_RS19240	COG1126	abc transporter atp-binding protein
GPY12_RS19250	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY12_RS19265	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY12_RS19280	COG0513	Belongs to the DEAD box helicase family
GPY12_RS19285	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY12_RS19295	COG0814	amino acid
GPY12_RS19305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY12_RS19310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY12_RS19315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY12_RS19320	COG1984	allophanate hydrolase subunit 2
GPY12_RS19335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY12_RS19340	COG4181	ATPase activity
GPY12_RS19350	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY12_RS19355	COG5001	Diguanylate cyclase
GPY12_RS19355	COG1716	ATPase activity
GPY12_RS19365	COG0484	heat shock protein binding
GPY12_RS19400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY12_RS19405	COG1368	sulfuric ester hydrolase activity
GPY12_RS19415	COG0513	Belongs to the DEAD box helicase family
GPY12_RS19420	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY12_RS19430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY12_RS19440	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY12_RS19445	COG3397	chitin binding
GPY12_RS19475	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY12_RS19490	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY12_RS19495	COG1129	ABC transporter
GPY12_RS19500	COG1454	alcohol dehydrogenase
GPY12_RS19505	COG0235	Class ii aldolase
GPY12_RS19510	COG4154	Belongs to the RbsD FucU family
GPY12_RS19515	COG1070	Carbohydrate kinase
GPY12_RS19520	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
GPY12_RS19525	COG1349	DNA-binding transcription factor activity
GPY12_RS19555	COG0561	phosphatase activity
GPY12_RS19560	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPY12_RS19565	COG3623	hexulose-6-phosphate isomerase
GPY12_RS19580	COG2149	membrane
GPY12_RS19590	COG1263	PTS System
GPY12_RS19590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY12_RS19595	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY12_RS19620	COG2801	Transposase and inactivated derivatives
GPY12_RS19640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY12_RS19660	COG4604	ABC transporter, ATP-binding protein
GPY12_RS19665	COG4605	iron ion homeostasis
GPY12_RS19670	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY12_RS19690	COG3291	Pkd domain containing protein
GPY12_RS19690	COG4412	M6 family metalloprotease domain protein
GPY12_RS19695	COG0840	transmembrane signaling receptor activity
GPY12_RS19705	COG3240	lipase activity
GPY12_RS19710	COG3706	GGDEF domain
GPY12_RS19720	COG2814	Major facilitator Superfamily
GPY12_RS19725	COG1757	Na H antiporter
GPY12_RS19735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY12_RS19735	COG4191	Histidine kinase
GPY12_RS19740	COG0784	Response regulator, receiver
GPY12_RS19740	COG3437	response regulator, receiver
GPY12_RS19745	COG0840	transmembrane signaling receptor activity
GPY12_RS19750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY12_RS19755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY12_RS19760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY12_RS19765	COG0513	Belongs to the DEAD box helicase family
GPY12_RS19775	COG0516	GMP reductase activity
GPY12_RS19785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY12_RS19795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY12_RS19800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY12_RS19800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY12_RS19825	COG3036	rescue of stalled ribosome
GPY12_RS19830	COG1278	Cold shock
GPY12_RS19835	COG1017	nitric oxide dioxygenase activity
GPY12_RS19835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY12_RS19840	COG3604	Transcriptional regulator
GPY12_RS19850	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY12_RS19855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY12_RS19870	COG0840	transmembrane signaling receptor activity
GPY12_RS19875	COG0714	Associated with various cellular activities
GPY12_RS19895	COG2304	oxidoreductase activity
GPY12_RS19910	COG1278	Cold shock
GPY12_RS19915	COG5002	protein histidine kinase activity
GPY12_RS19915	COG5001	Diguanylate cyclase
GPY12_RS19925	COG3530	Putative quorum-sensing-regulated virulence factor
GPY12_RS19935	COG3033	Beta-eliminating lyase
GPY12_RS19940	COG0814	amino acid
GPY12_RS19945	COG0488	(ABC) transporter
GPY12_RS19950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY12_RS19950	COG1017	nitric oxide dioxygenase activity
GPY12_RS19955	COG1609	Transcriptional regulator
GPY12_RS19960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY12_RS19975	COG0242	peptide deformylase activity
GPY12_RS20010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY12_RS20035	COG2271	Major facilitator Superfamily
GPY12_RS20040	COG0584	glycerophosphoryl diester phosphodiesterase
GPY12_RS20060	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY12_RS20070	COG1609	Transcriptional regulator
GPY12_RS20075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY12_RS20080	COG1879	ABC-type sugar transport system periplasmic component
GPY12_RS20085	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY12_RS20090	COG1129	ABC transporter
GPY12_RS20095	COG1869	D-ribose catabolic process
GPY12_RS20120	COG3501	Rhs element vgr protein
GPY12_RS20210	COG0564	pseudouridine synthase activity
GPY12_RS20220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY12_RS20225	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY12_RS20235	COG0673	inositol 2-dehydrogenase activity
GPY12_RS20240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY12_RS20270	COG1342	Belongs to the UPF0251 family
GPY12_RS20285	COG1301	dicarboxylic acid transport
GPY12_RS20290	COG0700	Nucleoside recognition
GPY12_RS20295	COG3366	ferrous iron transmembrane transporter activity
GPY12_RS20300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY12_RS20305	COG4565	transcriptional regulatory protein
GPY12_RS20315	COG0471	metal ion transport
GPY12_RS20325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY12_RS20330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY12_RS20335	COG2259	Doxx family
GPY12_RS20360	COG0363	glucosamine-6-phosphate deaminase activity
GPY12_RS20375	COG4580	involved in the transport of maltose and maltodextrins
GPY12_RS20385	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY12_RS20405	COG0840	transmembrane signaling receptor activity
GPY12_RS20420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY12_RS20450	COG1280	lysine exporter protein (LysE YggA)
GPY12_RS20465	COG0513	Belongs to the DEAD box helicase family
GPY12_RS20475	COG2186	Transcriptional regulator
GPY12_RS20485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY12_RS20495	COG0246	Mannitol dehydrogenase
GPY12_RS20500	COG1904	glucuronate isomerase
GPY12_RS20505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY12_RS20510	COG0800	Aldolase
GPY12_RS20520	COG0583	DNA-binding transcription factor activity
GPY12_RS20530	COG1902	pentaerythritol trinitrate reductase activity
GPY12_RS20540	COG1132	(ABC) transporter
GPY12_RS20550	COG1280	lysine exporter protein (LysE YggA)
GPY12_RS20555	COG2207	Transcriptional regulator
GPY12_RS20575	COG1846	Transcriptional regulator
GPY12_RS20580	COG1764	response to oxidative stress
GPY12_RS20585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY12_RS20590	COG0697	spore germination
GPY12_RS20595	COG0678	peroxiredoxin activity
GPY12_RS20595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY12_RS20610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY12_RS20615	COG0583	DNA-binding transcription factor activity
GPY12_RS20620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY12_RS20625	COG0569	domain protein
GPY12_RS20630	COG0745	RESPONSE REGULATOR receiver
GPY12_RS20635	COG2205	protein histidine kinase activity
GPY12_RS20650	COG2814	Major facilitator Superfamily
GPY12_RS20655	COG0583	DNA-binding transcription factor activity
GPY12_RS20665	COG0739	heme binding
GPY12_RS20675	COG0659	secondary active sulfate transmembrane transporter activity
GPY12_RS20695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY12_RS20700	COG0581	inorganic phosphate transmembrane transporter activity
GPY12_RS20705	COG0573	inorganic phosphate transmembrane transporter activity
GPY12_RS20710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY12_RS20720	COG0513	Belongs to the DEAD box helicase family
GPY12_RS20730	COG1376	ErfK ybiS ycfS ynhG family protein
GPY12_RS20730	COG1388	LysM domain
GPY12_RS20735	COG0415	Belongs to the DNA photolyase family
GPY12_RS20740	COG0789	Transcriptional regulator