locus-tag	class	description
AL543_RS00005	COG0641	radical SAM
AL543_RS00020	COG2814	Major facilitator Superfamily
AL543_RS00040	COG3335	DDE superfamily endonuclease
AL543_RS00050	COG1063	alcohol dehydrogenase
AL543_RS00080	COG3157	Type VI secretion system effector, Hcp
AL543_RS00090	COG1349	DNA-binding transcription factor activity
AL543_RS00095	COG2084	Dehydrogenase
AL543_RS00100	COG3395	kinase activity
AL543_RS00105	COG0235	Class ii aldolase
AL543_RS00110	COG3622	Belongs to the hyi family
AL543_RS00115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL543_RS00120	COG2610	gluconate transmembrane transporter activity
AL543_RS00225	COG0270	DNA (cytosine-5-)-methyltransferase activity
AL543_RS00270	COG1802	Transcriptional regulator
AL543_RS00270	COG4626	Terminase
AL543_RS00300	COG0582	viral genome integration into host DNA
AL543_RS00320	COG1063	alcohol dehydrogenase
AL543_RS00330	COG2873	o-acetylhomoserine
AL543_RS00340	COG0346	lactoylglutathione lyase activity
AL543_RS00355	COG3706	GGDEF domain
AL543_RS00355	COG4251	negative regulation of phosphorylation
AL543_RS00355	COG5001	Diguanylate cyclase
AL543_RS00355	COG2203	Gaf domain
AL543_RS00370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL543_RS00375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL543_RS00380	COG0363	glucosamine-6-phosphate deaminase activity
AL543_RS00385	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL543_RS00405	COG1929	Belongs to the glycerate kinase type-1 family
AL543_RS00410	COG2610	gluconate transmembrane transporter activity
AL543_RS00415	COG3835	regulator
AL543_RS00420	COG1858	cytochrome C peroxidase
AL543_RS00430	COG0748	coenzyme F420 binding
AL543_RS00435	COG3721	Heme iron utilization protein
AL543_RS00445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL543_RS00450	COG0811	peptide transport
AL543_RS00455	COG0848	biopolymer transport protein
AL543_RS00460	COG4558	Periplasmic binding protein
AL543_RS00465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL543_RS00470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL543_RS00510	COG3217	Mosc domain protein beta barrel domain protein
AL543_RS00510	COG0633	Ferredoxin
AL543_RS00510	COG3217	Mosc domain protein beta barrel domain protein
AL543_RS00510	COG0633	Ferredoxin
AL543_RS00515	COG0418	dihydroorotase activity
AL543_RS00525	COG3335	DDE superfamily endonuclease
AL543_RS00535	COG3152	Membrane
AL543_RS00545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL543_RS00550	COG2354	Protein conserved in bacteria
AL543_RS00555	COG0488	(ABC) transporter
AL543_RS00565	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL543_RS00570	COG1278	Cold shock
AL543_RS00600	COG2199	diguanylate cyclase activity
AL543_RS00605	COG1349	DNA-binding transcription factor activity
AL543_RS00615	COG0737	Belongs to the 5'-nucleotidase family
AL543_RS00630	COG3833	ABC-type maltose transport systems, permease component
AL543_RS00635	COG1175	transmembrane transport
AL543_RS00645	COG3842	ATPase activity
AL543_RS00650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_RS00665	COG0393	Putative heavy-metal-binding
AL543_RS00670	COG2197	response regulator
AL543_RS00695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL543_RS00700	COG0835	chemotaxis
AL543_RS00700	COG0784	Response regulator, receiver
AL543_RS00705	COG1846	Transcriptional regulator
AL543_RS00710	COG3706	GGDEF domain
AL543_RS00745	COG0583	DNA-binding transcription factor activity
AL543_RS00750	COG5001	Diguanylate cyclase
AL543_RS00760	COG1741	Belongs to the pirin family
AL543_RS00765	COG3123	guanosine phosphorylase activity
AL543_RS00775	COG2211	Major facilitator Superfamily
AL543_RS00785	COG1067	ATP-dependent peptidase activity
AL543_RS00795	COG4172	Belongs to the ABC transporter superfamily
AL543_RS00800	COG0583	DNA-binding transcription factor activity
AL543_RS00805	COG1620	l-lactate permease
AL543_RS00820	COG3385	transposase activity
AL543_RS00825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL543_RS00840	COG2172	sigma factor antagonist activity
AL543_RS00855	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL543_RS00860	COG0840	transmembrane signaling receptor activity
AL543_RS00865	COG0534	Mate efflux family protein
AL543_RS00875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL543_RS00880	COG1126	abc transporter atp-binding protein
AL543_RS00890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_RS00895	COG4215	(ABC) transporter
AL543_RS00900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL543_RS00910	COG0739	heme binding
AL543_RS00915	COG2213	PTS system mannitol-specific
AL543_RS00915	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS00920	COG0246	Mannitol dehydrogenase
AL543_RS00925	COG3722	fumarate hydratase activity
AL543_RS00930	COG0673	inositol 2-dehydrogenase activity
AL543_RS00960	COG0697	spore germination
AL543_RS00975	COG0583	DNA-binding transcription factor activity
AL543_RS00980	COG0655	NAD(P)H dehydrogenase (quinone) activity
AL543_RS00995	COG0697	spore germination
AL543_RS01000	COG2910	NAD(P)H-binding
AL543_RS01015	COG3335	DDE superfamily endonuclease
AL543_RS01020	COG4221	oxidoreductase activity
AL543_RS01035	COG1901	pseudouridine methyltransferase
AL543_RS01055	COG0531	amino acid
AL543_RS01060	COG1982	Orn Lys Arg decarboxylase major
AL543_RS01080	COG2197	response regulator
AL543_RS01120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL543_RS01145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL543_RS01190	COG3537	Alpha-1,2-mannosidase
AL543_RS01225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL543_RS01230	COG0840	transmembrane signaling receptor activity
AL543_RS01235	COG0835	chemotaxis
AL543_RS01240	COG0835	chemotaxis
AL543_RS01245	COG2198	Histidine kinase
AL543_RS01245	COG0643	Histidine kinase
AL543_RS01260	COG0747	negative chemotaxis
AL543_RS01265	COG0601	transmembrane transport
AL543_RS01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_RS01280	COG2194	sulfuric ester hydrolase activity
AL543_RS01290	COG0642	Histidine kinase
AL543_RS01305	COG1028	Short-chain dehydrogenase reductase Sdr
AL543_RS01325	COG1444	tRNA N-acetyltransferase activity
AL543_RS01330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL543_RS01370	COG0217	transcriptional regulatory protein
AL543_RS01375	COG2084	Dehydrogenase
AL543_RS01390	COG2909	trisaccharide binding
AL543_RS01395	COG0058	SHG alpha-glucan phosphorylase activity
AL543_RS01400	COG1640	4-alpha-glucanotransferase
AL543_RS01405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL543_RS01415	COG3501	Rhs element vgr protein
AL543_RS01450	COG0471	metal ion transport
AL543_RS01455	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL543_RS01485	COG0671	phosphoesterase, PA-phosphatase related
AL543_RS01495	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL543_RS01500	COG2847	Copper chaperone PCu(A)C
AL543_RS01505	COG1999	signal sequence binding
AL543_RS01525	COG0786	glutamate:sodium symporter activity
AL543_RS01540	COG3655	Transcriptional regulator
AL543_RS01555	COG1566	PFAM secretion protein HlyD family protein
AL543_RS01580	COG0813	purine-nucleoside phosphorylase activity
AL543_RS01590	COG3272	Protein of unknown function (DUF1722)
AL543_RS01595	COG0789	Transcriptional regulator
AL543_RS01600	COG0415	Belongs to the DNA photolyase family
AL543_RS01605	COG1388	LysM domain
AL543_RS01605	COG1376	ErfK ybiS ycfS ynhG family protein
AL543_RS01615	COG0513	Belongs to the DEAD box helicase family
AL543_RS01625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL543_RS01630	COG0573	inorganic phosphate transmembrane transporter activity
AL543_RS01635	COG0581	inorganic phosphate transmembrane transporter activity
AL543_RS01640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL543_RS01655	COG3314	Sporulation integral membrane protein YlbJ
AL543_RS01660	COG0659	secondary active sulfate transmembrane transporter activity
AL543_RS01670	COG0739	heme binding
AL543_RS01680	COG0583	DNA-binding transcription factor activity
AL543_RS01685	COG2814	Major facilitator Superfamily
AL543_RS01695	COG3335	DDE superfamily endonuclease
AL543_RS01715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL543_RS01730	COG0678	peroxiredoxin activity
AL543_RS01730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL543_RS01735	COG0697	spore germination
AL543_RS01740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL543_RS01745	COG1764	response to oxidative stress
AL543_RS01750	COG1846	Transcriptional regulator
AL543_RS01770	COG2207	Transcriptional regulator
AL543_RS01775	COG1280	lysine exporter protein (LysE YggA)
AL543_RS01785	COG1132	(ABC) transporter
AL543_RS01795	COG1902	pentaerythritol trinitrate reductase activity
AL543_RS01805	COG0583	DNA-binding transcription factor activity
AL543_RS01815	COG0800	Aldolase
AL543_RS01820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_RS01825	COG1904	glucuronate isomerase
AL543_RS01830	COG0246	Mannitol dehydrogenase
AL543_RS01840	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL543_RS01850	COG2186	Transcriptional regulator
AL543_RS01860	COG0513	Belongs to the DEAD box helicase family
AL543_RS01880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL543_RS01895	COG0840	transmembrane signaling receptor activity
AL543_RS01910	COG0840	transmembrane signaling receptor activity
AL543_RS01920	COG1914	H( )-stimulated, divalent metal cation uptake system
AL543_RS01930	COG4580	involved in the transport of maltose and maltodextrins
AL543_RS01945	COG0363	glucosamine-6-phosphate deaminase activity
AL543_RS01970	COG2259	Doxx family
AL543_RS01975	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL543_RS01980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL543_RS01990	COG0471	metal ion transport
AL543_RS02000	COG4565	transcriptional regulatory protein
AL543_RS02005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL543_RS02010	COG3366	ferrous iron transmembrane transporter activity
AL543_RS02015	COG0700	Nucleoside recognition
AL543_RS02020	COG1301	dicarboxylic acid transport
AL543_RS02035	COG1342	Belongs to the UPF0251 family
AL543_RS02065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL543_RS02070	COG0673	inositol 2-dehydrogenase activity
AL543_RS02080	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL543_RS02085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL543_RS02100	COG0564	pseudouridine synthase activity
AL543_RS02165	COG3829	transcription factor binding
AL543_RS02190	COG3501	Rhs element vgr protein
AL543_RS02190	COG3409	Peptidoglycan-binding domain 1 protein
AL543_RS02200	COG3335	DDE superfamily endonuclease
AL543_RS02215	COG1869	D-ribose catabolic process
AL543_RS02220	COG1129	ABC transporter
AL543_RS02225	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL543_RS02230	COG1879	ABC-type sugar transport system periplasmic component
AL543_RS02235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_RS02240	COG1609	Transcriptional regulator
AL543_RS02250	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL543_RS02260	COG0584	glycerophosphoryl diester phosphodiesterase
AL543_RS02265	COG2271	Major facilitator Superfamily
AL543_RS02310	COG0579	oxidoreductase
AL543_RS02320	COG0242	peptide deformylase activity
AL543_RS02335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS02340	COG1609	Transcriptional regulator
AL543_RS02345	COG1017	nitric oxide dioxygenase activity
AL543_RS02345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL543_RS02355	COG0814	amino acid
AL543_RS02375	COG3530	Putative quorum-sensing-regulated virulence factor
AL543_RS02385	COG5002	protein histidine kinase activity
AL543_RS02385	COG5001	Diguanylate cyclase
AL543_RS02390	COG1278	Cold shock
AL543_RS02420	COG2304	oxidoreductase activity
AL543_RS02440	COG0714	Associated with various cellular activities
AL543_RS02460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL543_RS02465	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL543_RS02475	COG3604	Transcriptional regulator
AL543_RS02480	COG1017	nitric oxide dioxygenase activity
AL543_RS02480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL543_RS02485	COG1278	Cold shock
AL543_RS02490	COG3036	rescue of stalled ribosome
AL543_RS02515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL543_RS02515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL543_RS02520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL543_RS02530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL543_RS02540	COG0516	GMP reductase activity
AL543_RS02545	COG4974	Belongs to the 'phage' integrase family
AL543_RS02640	COG4695	Portal protein
AL543_RS02780	COG0513	Belongs to the DEAD box helicase family
AL543_RS02785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL543_RS02790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL543_RS02795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL543_RS02800	COG0840	transmembrane signaling receptor activity
AL543_RS02805	COG3437	response regulator, receiver
AL543_RS02805	COG0784	Response regulator, receiver
AL543_RS02810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_RS02810	COG4191	Histidine kinase
AL543_RS02820	COG1757	Na H antiporter
AL543_RS02825	COG2814	Major facilitator Superfamily
AL543_RS02835	COG3706	GGDEF domain
AL543_RS02840	COG3240	lipase activity
AL543_RS02850	COG0840	transmembrane signaling receptor activity
AL543_RS02875	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL543_RS02880	COG4605	iron ion homeostasis
AL543_RS02885	COG4604	ABC transporter, ATP-binding protein
AL543_RS02905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL543_RS02925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_RS02925	COG1263	PTS System
AL543_RS02935	COG2149	membrane
AL543_RS02950	COG3623	hexulose-6-phosphate isomerase
AL543_RS02955	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL543_RS02960	COG0561	phosphatase activity
AL543_RS02995	COG3335	DDE superfamily endonuclease
AL543_RS03010	COG3335	DDE superfamily endonuclease
AL543_RS03015	COG4154	Belongs to the RbsD FucU family
AL543_RS03020	COG0235	Class ii aldolase
AL543_RS03035	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL543_RS03050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL543_RS03080	COG3397	chitin binding
AL543_RS03085	COG3046	protein related to deoxyribodipyrimidine photolyase
AL543_RS03095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL543_RS03110	COG0513	Belongs to the DEAD box helicase family
AL543_RS03120	COG1368	sulfuric ester hydrolase activity
AL543_RS03125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_RS03160	COG0484	heat shock protein binding
AL543_RS03170	COG1716	ATPase activity
AL543_RS03170	COG5001	Diguanylate cyclase
AL543_RS03175	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL543_RS03185	COG4181	ATPase activity
AL543_RS03190	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL543_RS03205	COG1984	allophanate hydrolase subunit 2
AL543_RS03210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL543_RS03215	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL543_RS03220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL543_RS03230	COG0814	amino acid
AL543_RS03240	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL543_RS03245	COG0513	Belongs to the DEAD box helicase family
AL543_RS03260	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL543_RS03265	COG0494	nUDIX hydrolase
AL543_RS03275	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL543_RS03285	COG1126	abc transporter atp-binding protein
AL543_RS03290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_RS03295	COG4215	(ABC) transporter
AL543_RS03300	COG4160	amino acid transport
AL543_RS03305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL543_RS03310	COG0583	DNA-binding transcription factor activity
AL543_RS03315	COG3335	DDE superfamily endonuclease
AL543_RS03325	COG0243	molybdopterin cofactor binding
AL543_RS03350	COG0477	Major facilitator Superfamily
AL543_RS03355	COG3118	belongs to the thioredoxin family
AL543_RS03360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL543_RS03370	COG1215	transferase activity, transferring glycosyl groups
AL543_RS03380	COG0247	lactate metabolic process
AL543_RS03385	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AL543_RS03390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL543_RS03400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL543_RS03405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL543_RS03415	COG2926	Belongs to the UPF0265 family
AL543_RS03430	COG3335	DDE superfamily endonuclease
AL543_RS03435	COG2827	Endonuclease containing a URI domain
AL543_RS03445	COG1879	ABC-type sugar transport system periplasmic component
AL543_RS03450	COG5002	protein histidine kinase activity
AL543_RS03450	COG0784	Response regulator, receiver
AL543_RS03470	COG1492	cobalamin metabolic process
AL543_RS03475	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL543_RS03480	COG4149	molybdate abc transporter
AL543_RS03485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL543_RS03505	COG1289	transmembrane transporter activity
AL543_RS03510	COG0210	DNA helicase
AL543_RS03535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL543_RS03540	COG3335	DDE superfamily endonuclease
AL543_RS03550	COG1335	isochorismatase
AL543_RS03555	COG1803	Methylglyoxal synthase
AL543_RS03560	COG1879	ABC-type sugar transport system periplasmic component
AL543_RS03565	COG2205	protein histidine kinase activity
AL543_RS03565	COG2198	Histidine kinase
AL543_RS03565	COG0784	Response regulator, receiver
AL543_RS03570	COG0469	pyruvate kinase activity
AL543_RS03575	COG2271	Major facilitator Superfamily
AL543_RS03590	COG4191	Histidine kinase
AL543_RS03615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL543_RS03635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL543_RS03640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL543_RS03650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL543_RS03655	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL543_RS03675	COG0183	Belongs to the thiolase family
AL543_RS03685	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL543_RS03695	COG0583	DNA-binding transcription factor activity
AL543_RS03715	COG4964	Belongs to the GSP D family
AL543_RS03770	COG3842	ATPase activity
AL543_RS03780	COG1840	ABC-type Fe3 transport system, periplasmic component
AL543_RS03785	COG2271	Major facilitator Superfamily
AL543_RS03790	COG3851	Histidine kinase
AL543_RS03795	COG2197	response regulator
AL543_RS03800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL543_RS03810	COG3005	denitrification pathway
AL543_RS03820	COG0243	molybdopterin cofactor binding
AL543_RS03830	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL543_RS03830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL543_RS03835	COG3850	Histidine kinase
AL543_RS03840	COG2197	response regulator
AL543_RS03845	COG1760	l-serine dehydratase
AL543_RS03850	COG3069	C4-dicarboxylate transmembrane transporter activity
AL543_RS03855	COG0840	transmembrane signaling receptor activity
AL543_RS03860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL543_RS03865	COG0545	Peptidyl-prolyl cis-trans isomerase
AL543_RS03875	COG0840	transmembrane signaling receptor activity
AL543_RS03880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL543_RS03995	COG0583	DNA-binding transcription factor activity
AL543_RS04030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL543_RS04060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL543_RS04070	COG2390	Transcriptional regulator
AL543_RS04080	COG2897	thiosulfate sulfurtransferase activity
AL543_RS04090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL543_RS04100	COG0302	gtp cyclohydrolase
AL543_RS04105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_RS04105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_RS04110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL543_RS04115	COG1970	mechanosensitive ion channel activity
AL543_RS04120	COG1454	alcohol dehydrogenase
AL543_RS04125	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL543_RS04135	COG1011	Hydrolase
AL543_RS04140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL543_RS04145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL543_RS04150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL543_RS04155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL543_RS04160	COG1840	ABC-type Fe3 transport system, periplasmic component
AL543_RS04165	COG3842	ATPase activity
AL543_RS04185	COG3104	oligopeptide transport
AL543_RS04210	COG4166	transmembrane transport
AL543_RS04215	COG4174	ABC transporter (Permease)
AL543_RS04220	COG4239	(ABC) transporter, permease
AL543_RS04225	COG4172	Belongs to the ABC transporter superfamily
AL543_RS04235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL543_RS04250	COG0625	glutathione transferase activity
AL543_RS04270	COG2050	protein possibly involved in aromatic compounds catabolism
AL543_RS04290	COG0583	DNA-binding transcription factor activity
AL543_RS04295	COG1042	CoA-binding domain protein
AL543_RS04295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_RS04295	COG0045	succinate-CoA ligase (ADP-forming) activity
AL543_RS04315	COG0023	Translation Initiation Factor
AL543_RS04325	COG1132	(ABC) transporter
AL543_RS04330	COG1132	(ABC) transporter
AL543_RS04335	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL543_RS04360	COG2226	methyltransferase
AL543_RS04360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL543_RS04360	COG3433	isochorismatase activity
AL543_RS04365	COG2814	Major facilitator Superfamily
AL543_RS04370	COG4771	TonB-dependent receptor
AL543_RS04455	COG3140	Belongs to the UPF0181 family
AL543_RS04480	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL543_RS04485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL543_RS04520	COG3706	GGDEF domain
AL543_RS04555	COG2824	Alkylphosphonate utilization operon protein PhnA
AL543_RS04570	COG0737	Belongs to the 5'-nucleotidase family
AL543_RS04575	COG3593	DNA synthesis involved in DNA repair
AL543_RS04585	COG0583	DNA-binding transcription factor activity
AL543_RS04590	COG2116	formate transmembrane transporter activity
AL543_RS04600	COG3038	cytochrome b561
AL543_RS04610	COG5001	Diguanylate cyclase
AL543_RS04610	COG3300	MHYT domain
AL543_RS04635	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AL543_RS04640	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AL543_RS04645	COG1737	Transcriptional regulator
AL543_RS04650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL543_RS04655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL543_RS04660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL543_RS04665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL543_RS04680	COG1940	carbohydrate kinase activity
AL543_RS04685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL543_RS04690	COG3335	DDE superfamily endonuclease
AL543_RS04700	COG3335	DDE superfamily endonuclease
AL543_RS04715	COG0523	cobalamin synthesis protein
AL543_RS04720	COG0038	chloride channel
AL543_RS04740	COG0156	8-amino-7-oxononanoate synthase activity
AL543_RS04745	COG0784	Response regulator, receiver
AL543_RS04745	COG2205	protein histidine kinase activity
AL543_RS04750	COG0419	ATPase involved in DNA repair
AL543_RS04755	COG0420	3'-5' exonuclease activity
AL543_RS04760	COG1609	Transcriptional regulator
AL543_RS04765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS04765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS04770	COG1105	Belongs to the carbohydrate kinase PfkB family
AL543_RS04775	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL543_RS04775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_RS04775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_RS04780	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL543_RS04785	COG0189	ligase activity
AL543_RS04785	COG4067	protein conserved in archaea
AL543_RS04795	COG0602	queuosine metabolic process
AL543_RS04800	COG1328	CTP reductase activity
AL543_RS04810	COG4977	sequence-specific DNA binding
AL543_RS04810	COG1917	Cupin 2, conserved barrel domain protein
AL543_RS04820	COG3335	DDE superfamily endonuclease
AL543_RS04910	COG0346	lactoylglutathione lyase activity
AL543_RS04935	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_RS04960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_RS05000	COG3335	DDE superfamily endonuclease
AL543_RS05030	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_RS05515	COG3335	DDE superfamily endonuclease
AL543_RS05640	COG4628	conserved protein (DUF2132)
AL543_RS05680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_RS05760	COG0110	maltose O-acetyltransferase activity
AL543_RS05775	COG3093	addiction module antidote protein HigA
AL543_RS05780	COG3549	Plasmid maintenance system killer
AL543_RS05790	COG0346	lactoylglutathione lyase activity
AL543_RS05830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_RS05920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_RS05955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_RS06125	COG4115	mRNA cleavage
AL543_RS06130	COG2161	toxin-antitoxin pair type II binding
AL543_RS06235	COG0653	protein targeting
AL543_RS06240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL543_RS06240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL543_RS06265	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_RS06275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_RS06335	COG0653	protein targeting
AL543_RS06350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL543_RS06355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL543_RS06370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL543_RS06380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL543_RS06385	COG0509	glycine decarboxylation via glycine cleavage system
AL543_RS06395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL543_RS06395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL543_RS06400	COG2755	lipolytic protein G-D-S-L family
AL543_RS06405	COG3338	carbonate dehydratase activity
AL543_RS06420	COG1686	Belongs to the peptidase S11 family
AL543_RS06425	COG1414	Transcriptional regulator
AL543_RS06440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_RS06445	COG0601	transmembrane transport
AL543_RS06460	COG0641	radical SAM
AL543_RS06465	COG3119	arylsulfatase activity
AL543_RS06470	COG3119	arylsulfatase activity
AL543_RS06475	COG2199	diguanylate cyclase activity
AL543_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
AL543_RS06500	COG1085	galactose-1-phosphate uridylyltransferase
AL543_RS06505	COG0800	Aldolase
AL543_RS06510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_RS06530	COG1166	arginine decarboxylase activity
AL543_RS06555	COG2239	Acts as a magnesium transporter
AL543_RS06560	COG0527	aspartate kinase activity
AL543_RS06565	COG0662	Cupin 2, conserved barrel domain protein
AL543_RS06570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL543_RS06575	COG0456	acetyltransferase
AL543_RS06590	COG0534	Mate efflux family protein
AL543_RS06600	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL543_RS06605	COG3186	Phenylalanine-4-hydroxylase
AL543_RS06610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL543_RS06625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL543_RS06640	COG1253	flavin adenine dinucleotide binding
AL543_RS06645	COG1765	OsmC-like protein
AL543_RS06655	COG5001	Diguanylate cyclase
AL543_RS06675	COG0531	amino acid
AL543_RS06690	COG3279	Response regulator of the LytR AlgR family
AL543_RS06695	COG3275	phosphorelay sensor kinase activity
AL543_RS06710	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL543_RS06715	COG1136	(ABC) transporter
AL543_RS06725	COG4989	oxidoreductase activity
AL543_RS06730	COG0366	Alpha amylase catalytic
AL543_RS06735	COG3335	DDE superfamily endonuclease
AL543_RS06765	COG3227	Zinc metalloprotease (Elastase)
AL543_RS06770	COG3047	cAMP biosynthetic process
AL543_RS06780	COG1686	Belongs to the peptidase S11 family
AL543_RS06790	COG0587	DNA-directed DNA polymerase activity
AL543_RS06795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL543_RS06800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL543_RS06805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL543_RS06810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL543_RS06815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL543_RS06820	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL543_RS06830	COG0750	zinc metalloprotease
AL543_RS06835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL543_RS06840	COG0575	Belongs to the CDS family
AL543_RS06845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL543_RS06850	COG0233	cytoplasmic translational termination
AL543_RS06855	COG0528	UMP kinase activity
AL543_RS06860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL543_RS06865	COG0052	Belongs to the universal ribosomal protein uS2 family
AL543_RS06870	COG0024	Methionine aminopeptidase
AL543_RS06875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL543_RS06885	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL543_RS06890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL543_RS06895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL543_RS06900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL543_RS06915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL543_RS06915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL543_RS06920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL543_RS06925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL543_RS06930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL543_RS06940	COG1073	alpha beta
AL543_RS06945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL543_RS06950	COG2252	PERMEase
AL543_RS06955	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL543_RS06960	COG4067	protein conserved in archaea
AL543_RS06960	COG0189	ligase activity
AL543_RS06965	COG0189	ligase activity
AL543_RS06975	COG0733	neurotransmitter:sodium symporter activity
AL543_RS06980	COG2203	Gaf domain
AL543_RS06980	COG3706	GGDEF domain
AL543_RS06980	COG4251	negative regulation of phosphorylation
AL543_RS06980	COG5001	Diguanylate cyclase
AL543_RS07000	COG1477	protein flavinylation
AL543_RS07010	COG2871	sodium ion transport
AL543_RS07015	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL543_RS07020	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL543_RS07025	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL543_RS07030	COG1805	sodium ion transport
AL543_RS07035	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL543_RS07040	COG0271	Belongs to the BolA IbaG family
AL543_RS07045	COG2813	Specifically methylates the guanine in position
AL543_RS07055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL543_RS07060	COG2211	Major facilitator Superfamily
AL543_RS07070	COG1595	DNA-templated transcription, initiation
AL543_RS07085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL543_RS07090	COG0693	protein deglycase activity
AL543_RS07095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL543_RS07100	COG2166	iron-sulfur cluster assembly
AL543_RS07105	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL543_RS07110	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL543_RS07120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL543_RS07120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL543_RS07130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL543_RS07135	COG1074	ATP-dependent DNA helicase activity
AL543_RS07140	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL543_RS07155	COG3141	response to X-ray
AL543_RS07165	COG2171	N-acyltransferase activity
AL543_RS07185	COG0189	ligase activity
AL543_RS07185	COG0569	domain protein
AL543_RS07200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL543_RS07205	COG1609	Transcriptional regulator
AL543_RS07210	COG3385	transposase activity
AL543_RS07215	COG3250	beta-galactosidase activity
AL543_RS07230	COG1022	Amp-dependent synthetase and ligase
AL543_RS07240	COG0583	DNA-binding transcription factor activity
AL543_RS07245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL543_RS07250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL543_RS07265	COG0560	Phosphoserine phosphatase
AL543_RS07275	COG0813	purine-nucleoside phosphorylase activity
AL543_RS07280	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL543_RS07285	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL543_RS07290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL543_RS07300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL543_RS07305	COG0084	hydrolase, TatD family'
AL543_RS07310	COG3022	response to hydroperoxide
AL543_RS07315	COG1115	amino acid carrier protein
AL543_RS07330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL543_RS07335	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL543_RS07340	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL543_RS07345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL543_RS07350	COG0083	homoserine kinase activity
AL543_RS07370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL543_RS07380	COG0745	RESPONSE REGULATOR receiver
AL543_RS07385	COG5002	protein histidine kinase activity
AL543_RS07385	COG0784	Response regulator, receiver
AL543_RS07385	COG2198	Histidine kinase
AL543_RS07390	COG2203	Gaf domain
AL543_RS07390	COG5001	Diguanylate cyclase
AL543_RS07390	COG4251	negative regulation of phosphorylation
AL543_RS07390	COG3706	GGDEF domain
AL543_RS07395	COG1242	4 iron, 4 sulfur cluster binding
AL543_RS07400	COG0069	glutamate synthase activity
AL543_RS07400	COG0067	glutamate synthase
AL543_RS07400	COG0070	glutamate synthase
AL543_RS07410	COG0067	glutamate synthase
AL543_RS07410	COG0070	glutamate synthase
AL543_RS07410	COG0069	glutamate synthase activity
AL543_RS07415	COG0493	'glutamate synthase
AL543_RS07425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL543_RS07435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL543_RS07440	COG2860	membrane
AL543_RS07445	COG0583	DNA-binding transcription factor activity
AL543_RS07450	COG0730	response to heat
AL543_RS07455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL543_RS07460	COG0505	Belongs to the CarA family
AL543_RS07470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL543_RS07475	COG0494	nUDIX hydrolase
AL543_RS07480	COG0653	protein targeting
AL543_RS07500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL543_RS07505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL543_RS07510	COG0849	cell division
AL543_RS07515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL543_RS07520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL543_RS07525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL543_RS07530	COG0772	Belongs to the SEDS family
AL543_RS07535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL543_RS07545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL543_RS07550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL543_RS07555	COG0768	penicillin binding
AL543_RS07560	COG3116	cell division
AL543_RS07575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL543_RS07580	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL543_RS07585	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL543_RS07600	COG0737	Belongs to the 5'-nucleotidase family
AL543_RS07605	COG1227	inorganic diphosphatase activity
AL543_RS07610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL543_RS07615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL543_RS07620	COG4974	Belongs to the 'phage' integrase family
AL543_RS07625	COG0716	FMN binding
AL543_RS07645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL543_RS07650	COG1459	type II secretion system
AL543_RS07660	COG0237	dephospho-CoA kinase activity
AL543_RS07665	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL543_RS07675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL543_RS07680	COG0187	DNA topoisomerase II activity
AL543_RS07685	COG3150	esterase
AL543_RS07695	COG3151	Protein conserved in bacteria
AL543_RS07700	COG0494	nUDIX hydrolase
AL543_RS07705	COG1538	Outer membrane efflux protein
AL543_RS07715	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL543_RS07725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL543_RS07730	COG3025	triphosphatase activity
AL543_RS07735	COG1392	Phosphate transport regulator
AL543_RS07745	COG0306	phosphate transporter
AL543_RS07750	COG4991	sh3 domain protein
AL543_RS07760	COG3409	Peptidoglycan-binding domain 1 protein
AL543_RS07760	COG3267	Type II secretory pathway component ExeA
AL543_RS07765	COG0617	tRNA 3'-terminal CCA addition
AL543_RS07775	COG0814	amino acid
AL543_RS07780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL543_RS07785	COG0148	phosphopyruvate hydratase activity
AL543_RS07790	COG0504	CTP synthase activity
AL543_RS07795	COG3956	TIGRFAM MazG family protein
AL543_RS07800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL543_RS07810	COG3850	Histidine kinase
AL543_RS07810	COG2205	protein histidine kinase activity
AL543_RS07810	COG4999	Histidine kinase
AL543_RS07810	COG3437	response regulator, receiver
AL543_RS07815	COG5001	Diguanylate cyclase
AL543_RS07830	COG0736	holo-[acyl-carrier-protein] synthase activity
AL543_RS07835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL543_RS07840	COG1381	Involved in DNA repair and RecF pathway recombination
AL543_RS07845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL543_RS07850	COG0571	ribonuclease III activity
AL543_RS07860	COG0481	GTPase activity
AL543_RS07865	COG3086	response to oxidative stress
AL543_RS07880	COG1595	DNA-templated transcription, initiation
AL543_RS07890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL543_RS07900	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL543_RS07915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL543_RS07920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL543_RS07925	COG3079	Belongs to the UPF0149 family
AL543_RS07930	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL543_RS07940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL543_RS07945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL543_RS07950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL543_RS07955	COG0440	acetolactate synthase activity
AL543_RS07960	COG0028	Belongs to the TPP enzyme family
AL543_RS07965	COG1022	Amp-dependent synthetase and ligase
AL543_RS07970	COG0583	DNA-binding transcription factor activity
AL543_RS07980	COG0671	phosphoesterase, PA-phosphatase related
AL543_RS08000	COG0473	3-isopropylmalate dehydrogenase activity
AL543_RS08005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL543_RS08010	COG0066	3-isopropylmalate dehydratase activity
AL543_RS08065	COG3437	response regulator, receiver
AL543_RS08080	COG0795	lipopolysaccharide-transporting ATPase activity
AL543_RS08085	COG0795	lipopolysaccharide-transporting ATPase activity
AL543_RS08090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL543_RS08095	COG2927	DNA polymerase III (CHI subunit)
AL543_RS08100	COG0525	valine-tRNA ligase activity
AL543_RS08115	COG4269	membrane
AL543_RS08120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL543_RS08125	COG0564	pseudouridine synthase activity
AL543_RS08130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL543_RS08140	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL543_RS08155	COG0540	Belongs to the ATCase OTCase family
AL543_RS08170	COG0251	oxidation-reduction process
AL543_RS08175	COG0204	Acyl-transferase
AL543_RS08180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL543_RS08185	COG5007	Belongs to the BolA IbaG family
AL543_RS08195	COG2854	intermembrane phospholipid transfer
AL543_RS08200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL543_RS08205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL543_RS08210	COG1127	ABC transporter
AL543_RS08220	COG0517	IMP dehydrogenase activity
AL543_RS08220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL543_RS08235	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL543_RS08240	COG1137	ATPase activity
AL543_RS08250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL543_RS08255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS08260	COG1660	Displays ATPase and GTPase activities
AL543_RS08265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS08270	COG2239	Acts as a magnesium transporter
AL543_RS08275	COG0312	modulator of DNA gyrase
AL543_RS08280	COG3028	Belongs to the UPF0307 family
AL543_RS08285	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL543_RS08290	COG1178	ABC-type Fe3 transport system permease component
AL543_RS08300	COG0163	prenyltransferase activity
AL543_RS08305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL543_RS08315	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL543_RS08320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL543_RS08330	COG2105	PFAM AIG2 family protein
AL543_RS08335	COG2911	Protein conserved in bacteria
AL543_RS08340	COG0729	surface antigen
AL543_RS08345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_RS08350	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL543_RS08365	COG1136	(ABC) transporter
AL543_RS08385	COG0529	Catalyzes the synthesis of activated sulfate
AL543_RS08390	COG2895	sulfate adenylyltransferase (ATP) activity
AL543_RS08395	COG0175	sulfate reduction
AL543_RS08400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL543_RS08400	COG1648	precorrin-2 dehydrogenase activity
AL543_RS08405	COG0737	Belongs to the 5'-nucleotidase family
AL543_RS08415	COG0513	Belongs to the DEAD box helicase family
AL543_RS08420	COG2153	protein acetylation
AL543_RS08425	COG0697	spore germination
AL543_RS08430	COG3061	Opacity-associated protein A
AL543_RS08435	COG0545	Peptidyl-prolyl cis-trans isomerase
AL543_RS08445	COG0203	ribosomal protein L17
AL543_RS08450	COG0202	RNA polymerase activity
AL543_RS08455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL543_RS08460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL543_RS08465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL543_RS08470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL543_RS08475	COG0201	protein transport
AL543_RS08485	COG1841	ribosomal large subunit assembly
AL543_RS08490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL543_RS08495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL543_RS08505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL543_RS08510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL543_RS08515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL543_RS08520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL543_RS08525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL543_RS08530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL543_RS08535	COG0255	Belongs to the universal ribosomal protein uL29 family
AL543_RS08540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL543_RS08545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL543_RS08550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL543_RS08555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL543_RS08560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL543_RS08565	COG0089	rRNA binding
AL543_RS08570	COG0088	Forms part of the polypeptide exit tunnel
AL543_RS08575	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL543_RS08580	COG0051	transcription antitermination factor activity, RNA binding
AL543_RS08585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL543_RS08590	COG0557	exoribonuclease II activity
AL543_RS08595	COG3083	sulfuric ester hydrolase activity
AL543_RS08600	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL543_RS08620	COG1047	Peptidyl-prolyl cis-trans
AL543_RS08635	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL543_RS08640	COG0488	(ABC) transporter
AL543_RS08650	COG0429	hydrolase of the alpha beta-hydrolase fold
AL543_RS08660	COG3954	Phosphoribulokinase
AL543_RS08675	COG1012	belongs to the aldehyde dehydrogenase family
AL543_RS08685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL543_RS08695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL543_RS08710	COG0180	Tryptophanyl-tRNA synthetase
AL543_RS08715	COG0546	phosphoglycolate phosphatase activity
AL543_RS08720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL543_RS08725	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL543_RS08735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL543_RS08740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL543_RS08770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL543_RS08780	COG0678	peroxiredoxin activity
AL543_RS08780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL543_RS08785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL543_RS08795	COG0165	Argininosuccinate lyase
AL543_RS08800	COG0137	argininosuccinate synthase activity
AL543_RS08805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL543_RS08810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL543_RS08815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL543_RS08820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL543_RS08830	COG1045	serine acetyltransferase
AL543_RS08835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL543_RS08840	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL543_RS08845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL543_RS08850	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL543_RS08855	COG1053	succinate dehydrogenase
AL543_RS08860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL543_RS08865	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL543_RS08875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL543_RS08880	COG1509	lysine 2,3-aminomutase activity
AL543_RS08900	COG0459	protein refolding
AL543_RS08905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL543_RS08930	COG0149	triose-phosphate isomerase activity
AL543_RS08935	COG0534	Mate efflux family protein
AL543_RS08940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL543_RS08945	COG1575	Belongs to the MenA family. Type 1 subfamily
AL543_RS08950	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL543_RS08955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL543_RS08965	COG1609	Transcriptional regulator
AL543_RS08970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL543_RS08975	COG0254	rRNA binding
AL543_RS08985	COG0281	malic enzyme
AL543_RS08990	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL543_RS08995	COG0626	cystathionine gamma-synthase activity
AL543_RS09000	COG0527	aspartate kinase activity
AL543_RS09000	COG0460	homoserine dehydrogenase
AL543_RS09005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL543_RS09010	COG3074	FtsZ-dependent cytokinesis
AL543_RS09015	COG1494	fructose-1,6-bisphosphatase
AL543_RS09020	COG0205	6-phosphofructokinase activity
AL543_RS09025	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL543_RS09035	COG0745	RESPONSE REGULATOR receiver
AL543_RS09040	COG2205	protein histidine kinase activity
AL543_RS09050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL543_RS09060	COG1027	Aspartate ammonia-lyase
AL543_RS09065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL543_RS09070	COG4232	protein-disulfide reductase activity
AL543_RS09095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL543_RS09100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL543_RS09105	COG0194	GDP metabolic process
AL543_RS09110	COG1758	RNA polymerase activity
AL543_RS09115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL543_RS09120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL543_RS09125	COG2233	PERMEase
AL543_RS09140	COG1472	Belongs to the glycosyl hydrolase 3 family
AL543_RS09145	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL543_RS09150	COG1129	ABC transporter
AL543_RS09165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL543_RS09170	COG2183	response to ionizing radiation
AL543_RS09180	COG0596	Alpha beta hydrolase
AL543_RS09195	COG0494	nUDIX hydrolase
AL543_RS09200	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL543_RS09210	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL543_RS09215	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL543_RS09220	COG3156	type II secretion system protein K
AL543_RS09225	COG4795	General secretion pathway protein
AL543_RS09230	COG2165	general secretion pathway protein
AL543_RS09235	COG2165	general secretion pathway protein
AL543_RS09240	COG2165	general secretion pathway protein
AL543_RS09245	COG1459	type II secretion system
AL543_RS09250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL543_RS09260	COG3031	protein transport across the cell outer membrane
AL543_RS09265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL543_RS09270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL543_RS09280	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL543_RS09290	COG0456	acetyltransferase
AL543_RS09295	COG1490	D-aminoacyl-tRNA deacylase activity
AL543_RS09300	COG1295	ribonuclease BN
AL543_RS09310	COG1217	gtp-binding protein TYPA
AL543_RS09320	COG0174	glutamine synthetase
AL543_RS09330	COG3852	Histidine kinase
AL543_RS09340	COG5001	Diguanylate cyclase
AL543_RS09340	COG3300	MHYT domain
AL543_RS09345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL543_RS09355	COG3335	DDE superfamily endonuclease
AL543_RS09365	COG3335	DDE superfamily endonuclease
AL543_RS09425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL543_RS09430	COG1404	Belongs to the peptidase S8 family
AL543_RS09435	COG4206	TonB-dependent receptor
AL543_RS09440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL543_RS09475	COG2003	Belongs to the UPF0758 family
AL543_RS09530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL543_RS09535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL543_RS09540	COG2177	Part of the ABC transporter FtsEX involved in
AL543_RS09545	COG2884	Cell division ATP-binding protein ftsE
AL543_RS09550	COG0552	protein localization to endoplasmic reticulum
AL543_RS09555	COG0742	ribosomal rna small subunit methyltransferase
AL543_RS09590	COG0783	Belongs to the Dps family
AL543_RS09595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL543_RS09600	COG1280	lysine exporter protein (LysE YggA)
AL543_RS09605	COG2267	carboxylic ester hydrolase activity
AL543_RS09610	COG0561	phosphatase activity
AL543_RS09625	COG2199	diguanylate cyclase activity
AL543_RS09625	COG3287	FIST C domain
AL543_RS09625	COG2200	EAL domain
AL543_RS09630	COG1011	Hydrolase
AL543_RS09635	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL543_RS09645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL543_RS09650	COG0019	diaminopimelate decarboxylase activity
AL543_RS09660	COG1965	Belongs to the frataxin family
AL543_RS09665	COG3072	Adenylate cyclase
AL543_RS09675	COG0181	hydroxymethylbilane synthase activity
AL543_RS09680	COG1587	Uroporphyrinogen-III synthase
AL543_RS09685	COG2959	enzyme of heme biosynthesis
AL543_RS09690	COG3071	HemY protein
AL543_RS09705	COG3078	GTPase activator activity
AL543_RS09730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL543_RS09730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL543_RS09735	COG0456	acetyltransferase
AL543_RS09745	COG0084	hydrolase, TatD family'
AL543_RS09755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL543_RS09765	COG1580	Controls the rotational direction of flagella during chemotaxis
AL543_RS09775	COG3161	chorismate lyase activity
AL543_RS09780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL543_RS09785	COG2937	Belongs to the GPAT DAPAT family
AL543_RS09790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL543_RS09800	COG0534	Mate efflux family protein
AL543_RS09805	COG0805	protein transport
AL543_RS09810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL543_RS09815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL543_RS09830	COG2226	methyltransferase
AL543_RS09835	COG1322	Protein conserved in bacteria
AL543_RS09845	COG0840	transmembrane signaling receptor activity
AL543_RS09910	COG3335	DDE superfamily endonuclease
AL543_RS09925	COG2081	HI0933 family
AL543_RS09935	COG1528	Iron-storage protein
AL543_RS09945	COG0589	response to stress
AL543_RS09965	COG5002	protein histidine kinase activity
AL543_RS09965	COG5001	Diguanylate cyclase
AL543_RS09970	COG1522	sequence-specific DNA binding
AL543_RS09990	COG0006	proline dipeptidase activity
AL543_RS09990	COG0006	proline dipeptidase activity
AL543_RS09995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL543_RS10000	COG2022	thiamine diphosphate biosynthetic process
AL543_RS10005	COG2104	thiamine diphosphate biosynthetic process
AL543_RS10010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL543_RS10020	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL543_RS10025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL543_RS10035	COG0582	viral genome integration into host DNA
AL543_RS10050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL543_RS10055	COG1263	PTS System
AL543_RS10055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_RS10070	COG3335	DDE superfamily endonuclease
AL543_RS10170	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AL543_RS10175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL543_RS10180	COG1739	Uncharacterized protein family UPF0029
AL543_RS10185	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL543_RS10185	COG1024	Enoyl-CoA hydratase
AL543_RS10190	COG0183	Belongs to the thiolase family
AL543_RS10195	COG0583	DNA-binding transcription factor activity
AL543_RS10200	COG2814	Major facilitator Superfamily
AL543_RS10210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL543_RS10215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL543_RS10220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL543_RS10225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL543_RS10230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL543_RS10235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL543_RS10245	COG0356	it plays a direct role in the translocation of protons across the membrane
AL543_RS10250	COG3312	ion transport
AL543_RS10255	COG1475	DNA binding
AL543_RS10260	COG1192	Involved in chromosome partitioning
AL543_RS10265	COG0357	Ribosomal RNA small subunit methyltransferase G
AL543_RS10270	COG0445	tRNA wobble uridine modification
AL543_RS10275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL543_RS10290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL543_RS10295	COG0706	membrane insertase activity
AL543_RS10305	COG0594	ribonuclease P activity
AL543_RS10310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL543_RS10315	COG1126	abc transporter atp-binding protein
AL543_RS10330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL543_RS10335	COG0592	DNA-directed DNA polymerase activity
AL543_RS10340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL543_RS10345	COG0187	DNA topoisomerase II activity
AL543_RS10360	COG0071	Belongs to the small heat shock protein (HSP20) family
AL543_RS10365	COG3977	Valine--pyruvate aminotransferase
AL543_RS10370	COG0751	glycine-tRNA ligase activity
AL543_RS10375	COG0752	glycyl-tRNA synthetase alpha subunit
AL543_RS10380	COG2119	membrane
AL543_RS10390	COG0425	Belongs to the sulfur carrier protein TusA family
AL543_RS10405	COG0604	alcohol dehydrogenase
AL543_RS10415	COG0129	dihydroxy-acid dehydratase activity
AL543_RS10420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL543_RS10435	COG0606	chelatase, subunit chli
AL543_RS10440	COG0204	Acyl-transferase
AL543_RS10445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL543_RS10450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL543_RS10460	COG3084	Protein conserved in bacteria
AL543_RS10470	COG4326	sporulation control protein
AL543_RS10475	COG1272	protein, Hemolysin III
AL543_RS10485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL543_RS10490	COG0569	domain protein
AL543_RS10495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL543_RS10495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL543_RS10505	COG0242	peptide deformylase activity
AL543_RS10510	COG1652	LysM domain
AL543_RS10515	COG0758	DNA mediated transformation
AL543_RS10520	COG2922	Belongs to the Smg family
AL543_RS10525	COG0551	DNA topoisomerase type I activity
AL543_RS10530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL543_RS10535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL543_RS10540	COG0009	L-threonylcarbamoyladenylate synthase
AL543_RS10550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL543_RS10560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL543_RS10600	COG0583	DNA-binding transcription factor activity
AL543_RS10605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL543_RS10610	COG2960	long-chain fatty acid transporting porin activity
AL543_RS10615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL543_RS10620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL543_RS10625	COG1309	transcriptional regulator
AL543_RS10670	COG0747	negative chemotaxis
AL543_RS10675	COG0601	transmembrane transport
AL543_RS10680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_RS10725	COG3621	Patatin-like phospholipase
AL543_RS10780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL543_RS10785	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL543_RS10795	COG0210	DNA helicase
AL543_RS10805	COG1280	lysine exporter protein (LysE YggA)
AL543_RS10820	COG2962	Rard protein
AL543_RS10825	COG0514	ATP-dependent DNA helicase (RecQ)
AL543_RS10840	COG4774	siderophore transport
AL543_RS10845	COG1120	ATPase activity
AL543_RS10865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL543_RS10870	COG1263	PTS System
AL543_RS10870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_RS10875	COG2862	Uncharacterized protein family, UPF0114
AL543_RS10880	COG1561	YicC-like family, N-terminal region
AL543_RS10885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL543_RS10890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL543_RS10895	COG3385	transposase activity
AL543_RS10900	COG1560	Kdo2-lipid A biosynthetic process
AL543_RS10905	COG1560	Kdo2-lipid A biosynthetic process
AL543_RS10910	COG1309	transcriptional regulator
AL543_RS10920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL543_RS10930	COG2003	Belongs to the UPF0758 family
AL543_RS10935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL543_RS10940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL543_RS10950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL543_RS10955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL543_RS10960	COG0859	PFAM glycosyl transferase family 9
AL543_RS10975	COG0463	Glycosyl transferase, family 2
AL543_RS10980	COG0859	PFAM glycosyl transferase family 9
AL543_RS10985	COG3642	lipopolysaccharide core region biosynthetic process
AL543_RS11010	COG1519	Transferase
AL543_RS11050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL543_RS11055	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AL543_RS11070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL543_RS11075	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL543_RS11085	COG1216	Glycosyl transferase, family 2
AL543_RS11105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL543_RS11115	COG0668	transmembrane transport
AL543_RS11120	COG1573	uracil-dna glycosylase
AL543_RS11130	COG3068	Protein conserved in bacteria
AL543_RS11135	COG1253	flavin adenine dinucleotide binding
AL543_RS11140	COG0776	regulation of translation
AL543_RS11150	COG0151	Belongs to the GarS family
AL543_RS11165	COG0789	Transcriptional regulator
AL543_RS11170	COG3710	Transcriptional regulator
AL543_RS11175	COG0531	amino acid
AL543_RS11180	COG1982	Orn Lys Arg decarboxylase major
AL543_RS11185	COG0840	transmembrane signaling receptor activity
AL543_RS11200	COG0800	Aldolase
AL543_RS11205	COG2610	gluconate transmembrane transporter activity
AL543_RS11210	COG3265	gluconokinase activity
AL543_RS11215	COG0129	dihydroxy-acid dehydratase activity
AL543_RS11220	COG1609	Transcriptional regulator
AL543_RS11225	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL543_RS11230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL543_RS11235	COG2264	protein methyltransferase activity
AL543_RS11240	COG0439	Biotin carboxylase
AL543_RS11245	COG0511	ligase activity, forming carbon-carbon bonds
AL543_RS11250	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL543_RS11255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL543_RS11270	COG2814	Major facilitator Superfamily
AL543_RS11285	COG0248	Ppx GppA phosphatase
AL543_RS11290	COG0513	Belongs to the DEAD box helicase family
AL543_RS11295	COG3118	belongs to the thioredoxin family
AL543_RS11310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL543_RS11360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL543_RS11370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL543_RS11380	COG1072	(Pantothenic acid kinase))
AL543_RS11405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL543_RS11410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL543_RS11415	COG0250	Participates in transcription elongation, termination and antitermination
AL543_RS11420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL543_RS11430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL543_RS11435	COG0222	ribosome binding
AL543_RS11440	COG0085	RNA polymerase activity
AL543_RS11445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL543_RS11450	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL543_RS11455	COG2816	NAD+ diphosphatase activity
AL543_RS11460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL543_RS11475	COG4942	peptidase
AL543_RS11480	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL543_RS11490	COG0471	metal ion transport
AL543_RS11495	COG0688	phosphatidylethanolamine metabolic process
AL543_RS11500	COG1162	GTPase activity
AL543_RS11505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL543_RS11550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL543_RS11555	COG0802	atpase or kinase
AL543_RS11560	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL543_RS11565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL543_RS11570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL543_RS11575	COG1923	regulation of RNA biosynthetic process
AL543_RS11580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL543_RS11585	COG0330	HflC and HflK could
AL543_RS11590	COG0330	HflC and HflK could
AL543_RS11595	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL543_RS11600	COG2900	Belongs to the SlyX family
AL543_RS11610	COG0545	Peptidyl-prolyl cis-trans isomerase
AL543_RS11615	COG2964	Protein conserved in bacteria
AL543_RS11620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL543_RS11625	COG2923	Belongs to the DsrF TusC family
AL543_RS11640	COG0049	tRNA binding
AL543_RS11645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL543_RS11650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL543_RS11655	COG2906	2 iron, 2 sulfur cluster binding
AL543_RS11665	COG0360	Binds together with S18 to 16S ribosomal RNA
AL543_RS11670	COG2965	DNA replication, synthesis of RNA primer
AL543_RS11675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL543_RS11680	COG0359	binds to the 23S rRNA
AL543_RS11695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL543_RS11705	COG0166	Belongs to the GPI family
AL543_RS11715	COG0735	belongs to the Fur family
AL543_RS11720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL543_RS11745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL543_RS11755	COG0175	sulfate reduction
AL543_RS11825	COG0646	methionine synthase
AL543_RS11825	COG1410	methionine synthase
AL543_RS11830	COG0527	aspartate kinase activity
AL543_RS11835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL543_RS11845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL543_RS11865	COG2200	EAL domain
AL543_RS11865	COG2199	diguanylate cyclase activity
AL543_RS11890	COG3267	Type II secretory pathway component ExeA
AL543_RS11890	COG3409	Peptidoglycan-binding domain 1 protein
AL543_RS11900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL543_RS11905	COG1459	type II secretion system
AL543_RS11915	COG2165	general secretion pathway protein
AL543_RS11950	COG1077	Cell shape determining protein MreB Mrl
AL543_RS11955	COG1792	Involved in formation and maintenance of cell shape
AL543_RS11960	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL543_RS11965	COG0424	maF-like protein
AL543_RS11975	COG3164	Protein of unknown function
AL543_RS11980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL543_RS11985	COG0312	modulator of DNA gyrase
AL543_RS11990	COG1151	hydroxylamine reductase activity
AL543_RS11995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL543_RS12000	COG2235	arginine
AL543_RS12010	COG0837	glucose binding
AL543_RS12010	COG1737	Transcriptional regulator
AL543_RS12020	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AL543_RS12025	COG3335	DDE superfamily endonuclease
AL543_RS12045	COG4145	pantothenate transmembrane transporter activity
AL543_RS12055	COG2706	6-phosphogluconolactonase activity
AL543_RS12070	COG0589	response to stress
AL543_RS12080	COG2358	TRAP transporter, solute receptor (TAXI family
AL543_RS12090	COG1438	arginine binding
AL543_RS12095	COG0039	L-malate dehydrogenase activity
AL543_RS12100	COG0531	amino acid
AL543_RS12105	COG0142	geranyltranstransferase activity
AL543_RS12110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL543_RS12115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL543_RS12120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL543_RS12125	COG2966	Psort location CytoplasmicMembrane, score
AL543_RS12130	COG3610	response to peptide
AL543_RS12140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL543_RS12145	COG2967	ApaG domain
AL543_RS12150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL543_RS12155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL543_RS12160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL543_RS12165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL543_RS12170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL543_RS12200	COG0840	transmembrane signaling receptor activity
AL543_RS12225	COG0741	lytic transglycosylase activity
AL543_RS12230	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL543_RS12235	COG1194	a g-specific adenine glycosylase
AL543_RS12240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL543_RS12245	COG2066	Belongs to the glutaminase family
AL543_RS12255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL543_RS12260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL543_RS12275	COG0762	integral membrane protein
AL543_RS12280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL543_RS12285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL543_RS12305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL543_RS12310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL543_RS12315	COG1678	Uncharacterized ACR, COG1678
AL543_RS12320	COG0189	ligase activity
AL543_RS12325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL543_RS12330	COG2356	endonuclease I
AL543_RS12335	COG3091	SprT-like family
AL543_RS12340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL543_RS12350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL543_RS12355	COG0583	DNA-binding transcription factor activity
AL543_RS12360	COG4771	TonB-dependent receptor
AL543_RS12365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL543_RS12370	COG0126	phosphoglycerate kinase activity
AL543_RS12375	COG0191	fructose-bisphosphate aldolase activity
AL543_RS12380	COG0668	transmembrane transport
AL543_RS12390	COG1279	arginine transmembrane transporter activity
AL543_RS12410	COG1349	DNA-binding transcription factor activity
AL543_RS12415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL543_RS12420	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL543_RS12440	COG0358	DNA primase activity
AL543_RS12445	COG1610	YqeY-like protein
AL543_RS12450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL543_RS12455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL543_RS12460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL543_RS12465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL543_RS12475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL543_RS12480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL543_RS12485	COG1968	undecaprenyl-diphosphatase activity
AL543_RS12490	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL543_RS12495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL543_RS12500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL543_RS12505	COG0585	pseudouridine synthase activity
AL543_RS12510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL543_RS12515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL543_RS12525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL543_RS12530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL543_RS12550	COG4208	sulfate ABC transporter
AL543_RS12555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AL543_RS12560	COG1546	Belongs to the CinA family
AL543_RS12565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL543_RS12570	COG2137	regulation of response to DNA damage stimulus
AL543_RS12575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL543_RS12580	COG0527	aspartate kinase activity
AL543_RS12585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AL543_RS12630	COG3630	sodium ion export across plasma membrane
AL543_RS12635	COG0511	ligase activity, forming carbon-carbon bonds
AL543_RS12635	COG5016	pyruvate
AL543_RS12640	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL543_RS12650	COG1238	metal cluster binding
AL543_RS12655	COG0612	Peptidase, M16
AL543_RS12660	COG2918	glutathione biosynthetic process
AL543_RS12665	COG1854	S-ribosylhomocysteine lyase activity
AL543_RS12670	COG4536	flavin adenine dinucleotide binding
AL543_RS12675	COG4137	Cytochrome C assembly protein
AL543_RS12680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL543_RS12685	COG0228	four-way junction DNA binding
AL543_RS12690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL543_RS12695	COG0336	Belongs to the RNA methyltransferase TrmD family
AL543_RS12700	COG0335	large ribosomal subunit rRNA binding
AL543_RS12705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL543_RS12710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL543_RS12720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL543_RS12730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL543_RS12735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL543_RS12740	COG0723	plastoquinol--plastocyanin reductase activity
AL543_RS12745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL543_RS12750	COG2857	Cytochrome c1
AL543_RS12755	COG0625	glutathione transferase activity
AL543_RS12760	COG2969	positive regulation of protein catabolic process
AL543_RS12765	COG2823	Periplasmic or secreted lipoprotein
AL543_RS12770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL543_RS12775	COG0792	nuclease activity
AL543_RS12780	COG3107	peptidoglycan biosynthetic process
AL543_RS12785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL543_RS12800	COG0288	reversible hydration of carbon dioxide
AL543_RS12805	COG0659	secondary active sulfate transmembrane transporter activity
AL543_RS12810	COG1131	(ABC) transporter
AL543_RS12815	COG0842	Transport permease protein
AL543_RS12820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL543_RS12825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL543_RS12830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL543_RS12840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL543_RS12850	COG1489	DNA binding
AL543_RS12855	COG1643	Atp-dependent helicase
AL543_RS12860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL543_RS12865	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL543_RS12875	COG3112	Uncharacterised protein family (UPF0231)
AL543_RS12880	COG0347	Belongs to the P(II) protein family
AL543_RS12885	COG0004	ammonium transporteR
AL543_RS12890	COG1840	ABC-type Fe3 transport system, periplasmic component
AL543_RS12900	COG3842	ATPase activity
AL543_RS12905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL543_RS12925	COG2971	BadF BadG BcrA BcrD
AL543_RS12935	COG4608	Belongs to the ABC transporter superfamily
AL543_RS12940	COG0444	Belongs to the ABC transporter superfamily
AL543_RS12945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_RS12955	COG0747	negative chemotaxis
AL543_RS12965	COG2813	Specifically methylates the guanine in position
AL543_RS12970	COG0628	permease
AL543_RS12975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL543_RS12980	COG0316	Belongs to the HesB IscA family
AL543_RS12995	COG0739	heme binding
AL543_RS13000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL543_RS13005	COG2027	D-alanyl-D-alanine carboxypeptidase
AL543_RS13010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL543_RS13015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL543_RS13020	COG1534	Rna-binding protein
AL543_RS13025	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL543_RS13030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL543_RS13035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL543_RS13050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL543_RS13065	COG0779	Required for maturation of 30S ribosomal subunits
AL543_RS13070	COG0195	Participates in both transcription termination and antitermination
AL543_RS13075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL543_RS13080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL543_RS13090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL543_RS13105	COG1846	Transcriptional regulator
AL543_RS13115	COG0826	peptidase U32
AL543_RS13120	COG0826	peptidase U32
AL543_RS13130	COG3154	lipid carrier protein
AL543_RS13135	COG3153	acetyltransferase
AL543_RS13160	COG0513	Belongs to the DEAD box helicase family
AL543_RS13180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL543_RS13185	COG2204	response regulator
AL543_RS13200	COG0667	Aldo Keto reductase
AL543_RS13205	COG3066	DNA modification
AL543_RS13210	COG0494	nUDIX hydrolase
AL543_RS13215	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AL543_RS13220	COG0730	response to heat
AL543_RS13225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL543_RS13230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL543_RS13235	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL543_RS13240	COG3335	DDE superfamily endonuclease
AL543_RS13245	COG0583	DNA-binding transcription factor activity
AL543_RS13250	COG0640	Transcriptional regulator
AL543_RS13255	COG0268	Binds directly to 16S ribosomal RNA
AL543_RS13260	COG0728	peptidoglycan biosynthetic process
AL543_RS13265	COG0196	riboflavin kinase activity
AL543_RS13275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL543_RS13280	COG1047	Peptidyl-prolyl cis-trans
AL543_RS13285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL543_RS13290	COG1966	Carbon starvation protein
AL543_RS13305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL543_RS13310	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL543_RS13320	COG3279	Response regulator of the LytR AlgR family
AL543_RS13325	COG3275	phosphorelay sensor kinase activity
AL543_RS13330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL543_RS13335	COG0287	Prephenate dehydrogenase
AL543_RS13335	COG1605	Chorismate mutase
AL543_RS13345	COG0488	(ABC) transporter
AL543_RS13355	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL543_RS13365	COG5001	Diguanylate cyclase
AL543_RS13370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL543_RS13375	COG0077	Prephenate dehydratase
AL543_RS13375	COG1605	Chorismate mutase
AL543_RS13380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL543_RS13390	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL543_RS13395	COG0564	pseudouridine synthase activity
AL543_RS13400	COG1496	oxidoreductase activity
AL543_RS13405	COG0542	response to heat
AL543_RS13490	COG4771	TonB-dependent receptor
AL543_RS13500	COG4821	SIS domain
AL543_RS13550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL543_RS13555	COG0826	peptidase U32
AL543_RS13565	COG0745	RESPONSE REGULATOR receiver
AL543_RS13570	COG5002	protein histidine kinase activity
AL543_RS13580	COG0248	Ppx GppA phosphatase
AL543_RS13585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL543_RS13595	COG0581	inorganic phosphate transmembrane transporter activity
AL543_RS13600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL543_RS13615	COG3142	Participates in the control of copper homeostasis
AL543_RS13620	COG0450	alkyl hydroperoxide reductase
AL543_RS13625	COG0583	DNA-binding transcription factor activity
AL543_RS13630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL543_RS13640	COG0517	IMP dehydrogenase activity
AL543_RS13645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL543_RS13660	COG1862	Preprotein translocase
AL543_RS13665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL543_RS13670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL543_RS13675	COG0483	inositol monophosphate 1-phosphatase activity
AL543_RS13685	COG1959	2 iron, 2 sulfur cluster binding
AL543_RS13695	COG0822	iron-sulfur transferase activity
AL543_RS13705	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL543_RS13715	COG0633	Ferredoxin
AL543_RS13720	COG2975	iron-sulfur cluster assembly
AL543_RS13725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL543_RS13730	COG0105	UTP biosynthetic process
AL543_RS13735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL543_RS13740	COG1426	Protein conserved in bacteria
AL543_RS13745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL543_RS13750	COG0124	histidyl-tRNA synthetase
AL543_RS13755	COG2976	Protein conserved in bacteria
AL543_RS13760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL543_RS13765	COG1160	GTP binding
AL543_RS13780	COG1570	exodeoxyribonuclease VII activity
AL543_RS13785	COG0516	GMP reductase activity
AL543_RS13785	COG0517	IMP dehydrogenase activity
AL543_RS13790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL543_RS13790	COG0519	Catalyzes the synthesis of GMP from XMP
AL543_RS13795	COG0582	viral genome integration into host DNA
AL543_RS13805	COG0210	DNA helicase
AL543_RS13870	COG3335	DDE superfamily endonuclease
AL543_RS13915	COG1584	GPR1 FUN34 yaaH family protein
AL543_RS13925	COG0583	DNA-binding transcription factor activity
AL543_RS13935	COG1115	amino acid carrier protein
AL543_RS13945	COG0583	DNA-binding transcription factor activity
AL543_RS13960	COG2200	EAL domain
AL543_RS13970	COG4565	transcriptional regulatory protein
AL543_RS13980	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL543_RS13985	COG5016	pyruvate
AL543_RS13985	COG0511	ligase activity, forming carbon-carbon bonds
AL543_RS13990	COG3630	sodium ion export across plasma membrane
AL543_RS14000	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AL543_RS14005	COG3052	prosthetic group binding
AL543_RS14010	COG2301	Belongs to the HpcH HpaI aldolase family
AL543_RS14015	COG3051	citrate lyase alpha subunit
AL543_RS14035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL543_RS14040	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL543_RS14045	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AL543_RS14065	COG3335	DDE superfamily endonuclease
AL543_RS14085	COG3335	DDE superfamily endonuclease
AL543_RS14095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL543_RS14125	COG0582	viral genome integration into host DNA
AL543_RS14135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL543_RS14140	COG2867	negative regulation of translational initiation
AL543_RS14145	COG2914	Belongs to the UPF0125 (RnfH) family
AL543_RS14150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL543_RS14155	COG0497	DNA recombination
AL543_RS14160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL543_RS14165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL543_RS14170	COG0443	Heat shock 70 kDa protein
AL543_RS14175	COG0484	heat shock protein binding
AL543_RS14205	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL543_RS14215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL543_RS14225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL543_RS14225	COG0047	phosphoribosylformylglycinamidine synthase activity
AL543_RS14245	COG0442	prolyl-tRNA aminoacylation
AL543_RS14255	COG1720	tRNA m6t6A37 methyltransferase activity
AL543_RS14260	COG0254	rRNA binding
AL543_RS14265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL543_RS14270	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL543_RS14275	COG1671	Belongs to the UPF0178 family
AL543_RS14305	COG0564	pseudouridine synthase activity
AL543_RS14310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL543_RS14315	COG0142	geranyltranstransferase activity
AL543_RS14320	COG1722	exodeoxyribonuclease VII activity
AL543_RS14325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL543_RS14335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL543_RS14335	COG0301	tRNA thio-modification
AL543_RS14340	COG0583	DNA-binding transcription factor activity
AL543_RS14345	COG2363	Small membrane protein
AL543_RS14350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL543_RS14355	COG1611	Belongs to the LOG family
AL543_RS14370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL543_RS14370	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL543_RS14380	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL543_RS14385	COG1464	Belongs to the NlpA lipoprotein family
AL543_RS14390	COG2011	ABC-type metal ion transport system permease component
AL543_RS14395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL543_RS14400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL543_RS14405	COG1609	Transcriptional regulator
AL543_RS14410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_RS14410	COG1263	PTS System
AL543_RS14415	COG0366	Alpha amylase catalytic
AL543_RS14420	COG0745	RESPONSE REGULATOR receiver
AL543_RS14425	COG2205	protein histidine kinase activity
AL543_RS14460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL543_RS14475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL543_RS14480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL543_RS14485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL543_RS14510	COG1045	serine acetyltransferase
AL543_RS14530	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL543_RS14560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL543_RS14570	COG1596	polysaccharide export
AL543_RS14595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL543_RS14605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL543_RS14610	COG0321	lipoyl(octanoyl) transferase activity
AL543_RS14615	COG2921	Belongs to the UPF0250 family
AL543_RS14620	COG1686	Belongs to the peptidase S11 family
AL543_RS14625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL543_RS14630	COG0772	Belongs to the SEDS family
AL543_RS14635	COG0768	penicillin binding
AL543_RS14640	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL543_RS14645	COG0799	negative regulation of ribosome biogenesis
AL543_RS14650	COG1466	dna polymerase III delta subunit
AL543_RS14655	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL543_RS14660	COG0495	leucyl-tRNA aminoacylation
AL543_RS14665	COG2888	peptidyl-tyrosine sulfation
AL543_RS14670	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL543_RS14675	COG4535	Mg2 and Co2 transporter CorC
AL543_RS14680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL543_RS14685	COG1702	phosphate starvation-inducible protein PhoH
AL543_RS14690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL543_RS14695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL543_RS14700	COG2190	(PTS) system
AL543_RS14710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS14715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL543_RS14720	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL543_RS14725	COG3115	cell septum assembly
AL543_RS14730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL543_RS14745	COG0789	Transcriptional regulator
AL543_RS14750	COG3385	transposase activity
AL543_RS14755	COG1585	Membrane protein implicated in regulation of membrane protease activity
AL543_RS14760	COG0330	HflC and HflK could
AL543_RS14765	COG3118	belongs to the thioredoxin family
AL543_RS14775	COG0300	oxidoreductase activity
AL543_RS14780	COG1090	epimerase
AL543_RS14785	COG0622	Phosphoesterase
AL543_RS14800	COG3710	Transcriptional regulator
AL543_RS14805	COG0326	Molecular chaperone. Has ATPase activity
AL543_RS14810	COG0563	adenylate kinase activity
AL543_RS14815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL543_RS14820	COG3104	oligopeptide transport
AL543_RS14825	COG0250	Participates in transcription elongation, termination and antitermination
AL543_RS14830	COG0367	asparagine synthase
AL543_RS14835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL543_RS14835	COG4651	solute:proton antiporter activity
AL543_RS14840	COG1940	carbohydrate kinase activity
AL543_RS14840	COG1846	Transcriptional regulator
AL543_RS14845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL543_RS14850	COG2190	(PTS) system
AL543_RS14850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_RS14850	COG1263	PTS System
AL543_RS14865	COG0101	tRNA pseudouridine synthase activity
AL543_RS14870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL543_RS14875	COG0285	dihydrofolate synthase activity
AL543_RS14880	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL543_RS14885	COG1286	toxin biosynthetic process
AL543_RS14890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL543_RS14895	COG2056	Na+-H+ antiporter family
AL543_RS14900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL543_RS14915	COG0346	lactoylglutathione lyase activity
AL543_RS14920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL543_RS14925	COG4660	Part of a membrane complex involved in electron transport
AL543_RS14935	COG4658	electron transport chain
AL543_RS14940	COG4656	Part of a membrane complex involved in electron transport
AL543_RS14945	COG2878	Part of a membrane complex involved in electron transport
AL543_RS14950	COG4657	Part of a membrane complex involved in electron transport
AL543_RS14965	COG0556	nucleotide-excision repair
AL543_RS14970	COG2204	response regulator
AL543_RS14975	COG2198	Histidine kinase
AL543_RS14980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL543_RS14985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL543_RS14990	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL543_RS14995	COG0315	cyclic pyranopterin monophosphate synthase activity
AL543_RS15000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL543_RS15005	COG0314	molybdopterin synthase activity
AL543_RS15020	COG0517	IMP dehydrogenase activity
AL543_RS15020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL543_RS15020	COG0617	tRNA 3'-terminal CCA addition
AL543_RS15030	COG3335	DDE superfamily endonuclease
AL543_RS15035	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL543_RS15045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL543_RS15045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL543_RS15060	COG0572	uridine kinase
AL543_RS15065	COG2982	Protein involved in outer membrane biogenesis
AL543_RS15070	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL543_RS15075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL543_RS15080	COG2067	long-chain fatty acid transport protein
AL543_RS15085	COG2067	long-chain fatty acid transport protein
AL543_RS15105	COG0183	Belongs to the thiolase family
AL543_RS15110	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL543_RS15110	COG1024	Enoyl-CoA hydratase
AL543_RS15115	COG0778	Nitroreductase
AL543_RS15120	COG0583	DNA-binding transcription factor activity
AL543_RS15125	COG0745	RESPONSE REGULATOR receiver
AL543_RS15135	COG2832	Protein of unknown function (DUF454)
AL543_RS15140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL543_RS15150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL543_RS15155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL543_RS15165	COG2983	Belongs to the UPF0260 family
AL543_RS15170	COG1028	Short-chain dehydrogenase reductase Sdr
AL543_RS15175	COG0616	signal peptide processing
AL543_RS15185	COG1522	sequence-specific DNA binding
AL543_RS15190	COG1946	Acyl-CoA thioesterase
AL543_RS15210	COG5001	Diguanylate cyclase
AL543_RS15210	COG3300	MHYT domain
AL543_RS15265	COG4264	IucA IucC family
AL543_RS15275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL543_RS15280	COG1120	ATPase activity
AL543_RS15310	COG0662	Cupin 2, conserved barrel domain protein
AL543_RS15315	COG1960	acyl-CoA dehydrogenase activity
AL543_RS15320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL543_RS15325	COG2076	Multidrug Resistance protein
AL543_RS15330	COG2076	Multidrug Resistance protein
AL543_RS15335	COG0590	tRNA wobble adenosine to inosine editing
AL543_RS15350	COG0640	Transcriptional regulator
AL543_RS15355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL543_RS15370	COG1349	DNA-binding transcription factor activity
AL543_RS15380	COG1349	DNA-binding transcription factor activity
AL543_RS15390	COG2222	sugar isomerase
AL543_RS15395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_RS15400	COG3715	PTS system
AL543_RS15405	COG3716	PTS system mannose fructose sorbose family IID component
AL543_RS15410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS15435	COG3335	DDE superfamily endonuclease
AL543_RS15455	COG1881	PFAM PEBP family protein
AL543_RS15470	COG0009	L-threonylcarbamoyladenylate synthase
AL543_RS15485	COG2201	protein-glutamate methylesterase activity
AL543_RS15495	COG5002	protein histidine kinase activity
AL543_RS15500	COG4191	Histidine kinase
AL543_RS15505	COG3300	MHYT domain
AL543_RS15505	COG5001	Diguanylate cyclase
AL543_RS15510	COG2204	response regulator
AL543_RS15530	COG0601	transmembrane transport
AL543_RS15535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_RS15545	COG4608	Belongs to the ABC transporter superfamily
AL543_RS15550	COG0435	Glutathione S-transferase
AL543_RS15555	COG0280	phosphate acetyltransferase
AL543_RS15555	COG0857	belongs to the CobB CobQ family
AL543_RS15560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL543_RS15565	COG3092	negative regulation of chromosome organization
AL543_RS15570	COG4628	conserved protein (DUF2132)
AL543_RS15580	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL543_RS15590	COG3706	GGDEF domain
AL543_RS15595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL543_RS15605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL543_RS15610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL543_RS15615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL543_RS15620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL543_RS15625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL543_RS15630	COG0156	8-amino-7-oxononanoate synthase activity
AL543_RS15635	COG2226	methyltransferase
AL543_RS15640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL543_RS15650	COG0501	Belongs to the peptidase M48B family
AL543_RS15660	COG0300	oxidoreductase activity
AL543_RS15675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL543_RS15685	COG2268	Band 7 protein
AL543_RS15695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL543_RS15700	COG2915	High frequency lysogenization protein hflD homolog
AL543_RS15705	COG0482	sulfurtransferase activity
AL543_RS15710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_RS15715	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL543_RS15720	COG1757	Na H antiporter
AL543_RS15725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL543_RS15730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL543_RS15735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL543_RS15740	COG0131	Imidazoleglycerol-phosphate dehydratase
AL543_RS15740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL543_RS15745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL543_RS15750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL543_RS15755	COG0107	imidazoleglycerol-phosphate synthase activity
AL543_RS15760	COG0140	phosphoribosyl-ATP diphosphatase activity
AL543_RS15760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL543_RS15765	COG1187	pseudouridine synthase activity
AL543_RS15775	COG1278	Cold shock
AL543_RS15780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL543_RS15785	COG0542	response to heat
AL543_RS15790	COG3273	potassium ion transport
AL543_RS15790	COG2985	domain, Protein
AL543_RS15795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL543_RS15805	COG1979	alcohol dehydrogenase
AL543_RS15810	COG1737	Transcriptional regulator
AL543_RS15820	COG0076	glutamate decarboxylase activity
AL543_RS15830	COG2431	L-lysine efflux transmembrane transporter activity
AL543_RS15840	COG3070	regulator of competence-specific genes
AL543_RS15860	COG3852	Histidine kinase
AL543_RS15870	COG3385	transposase activity
AL543_RS15875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL543_RS15890	COG4067	protein conserved in archaea
AL543_RS15890	COG0189	ligase activity
AL543_RS15895	COG0500	methyltransferase
AL543_RS15900	COG4106	trans-aconitate 2-methyltransferase activity
AL543_RS15905	COG1801	Protein of unknown function DUF72
AL543_RS15910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL543_RS15915	COG1435	thymidine kinase activity
AL543_RS15925	COG0159	tryptophan synthase activity
AL543_RS15930	COG0133	tryptophan synthase activity
AL543_RS15935	COG0134	indole-3-glycerol-phosphate synthase activity
AL543_RS15935	COG0135	phosphoribosylanthranilate isomerase activity
AL543_RS15940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL543_RS15945	COG0512	Glutamine amidotransferase of anthranilate synthase
AL543_RS15950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL543_RS15960	COG0613	PHP domain protein
AL543_RS15965	COG0009	L-threonylcarbamoyladenylate synthase
AL543_RS15970	COG1187	pseudouridine synthase activity
AL543_RS15975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL543_RS15980	COG4988	ABC transporter
AL543_RS15985	COG0492	ferredoxin-NADP+ reductase activity
AL543_RS15995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL543_RS16000	COG3706	GGDEF domain
AL543_RS16005	COG2949	membrane
AL543_RS16015	COG0281	malic enzyme
AL543_RS16025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL543_RS16045	COG2885	chlorophyll binding
AL543_RS16060	COG0277	FAD linked oxidase domain protein
AL543_RS16060	COG0247	lactate metabolic process
AL543_RS16080	COG2986	histidine ammonia-lyase
AL543_RS16085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL543_RS16090	COG0010	Belongs to the arginase family
AL543_RS16095	COG1228	amidohydrolase
AL543_RS16110	COG3099	Belongs to the UPF0263 family
AL543_RS16115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL543_RS16125	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL543_RS16130	COG0417	DNA replication proofreading
AL543_RS16135	COG2197	response regulator
AL543_RS16140	COG0322	excinuclease ABC activity
AL543_RS16180	COG3335	DDE superfamily endonuclease
AL543_RS16190	COG0456	acetyltransferase
AL543_RS16195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL543_RS16200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL543_RS16200	COG0072	phenylalanine-tRNA ligase activity
AL543_RS16205	COG0776	regulation of translation
AL543_RS16220	COG0500	methyltransferase
AL543_RS16240	COG1346	cytolysis
AL543_RS16245	COG1380	Effector of murein hydrolase LrgA
AL543_RS16250	COG2925	Exonuclease
AL543_RS16255	COG1823	symporter activity
AL543_RS16260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_RS16265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL543_RS16270	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL543_RS16285	COG2988	succinylglutamate desuccinylase activity
AL543_RS16290	COG4139	cobalamin transport
AL543_RS16310	COG0840	transmembrane signaling receptor activity
AL543_RS16345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL543_RS16355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL543_RS16370	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL543_RS16380	COG0437	4 iron, 4 sulfur cluster binding
AL543_RS16385	COG3301	Polysulphide reductase, NrfD
AL543_RS16390	COG1138	Cytochrome C-type biogenesis protein
AL543_RS16400	COG4235	cytochrome complex assembly
AL543_RS16400	COG3088	subunit of a heme lyase
AL543_RS16410	COG1278	Cold shock
AL543_RS16415	COG1054	Belongs to the UPF0176 family
AL543_RS16450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL543_RS16480	COG3108	Peptidase M15
AL543_RS16485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL543_RS16500	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL543_RS16530	COG1846	Transcriptional regulator
AL543_RS16535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL543_RS16540	COG0726	polysaccharide deacetylase
AL543_RS16545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL543_RS16555	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL543_RS16560	COG1486	melibiose metabolic process
AL543_RS16565	COG3394	polysaccharide catabolic process
AL543_RS16570	COG1609	Transcriptional regulator
AL543_RS16575	COG2943	transferase activity, transferring hexosyl groups
AL543_RS16580	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AL543_RS16600	COG1448	Aminotransferase
AL543_RS16605	COG3437	response regulator, receiver
AL543_RS16605	COG2770	Histidine kinase
AL543_RS16610	COG0110	maltose O-acetyltransferase activity
AL543_RS16615	COG0351	phosphomethylpyrimidine kinase
AL543_RS16620	COG0017	Asparaginyl-tRNA synthetase
AL543_RS16625	COG0840	transmembrane signaling receptor activity
AL543_RS16630	COG0720	synthase
AL543_RS16635	COG1760	l-serine dehydratase
AL543_RS16640	COG0814	amino acid
AL543_RS16645	COG0494	nUDIX hydrolase
AL543_RS16665	COG3106	COG3106 Predicted ATPase
AL543_RS16670	COG3768	UPF0283 membrane protein
AL543_RS16680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_RS16700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL543_RS16705	COG0840	transmembrane signaling receptor activity
AL543_RS16710	COG0471	metal ion transport
AL543_RS16715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_RS16715	COG4191	Histidine kinase
AL543_RS16730	COG3713	MltA-interacting MipA family protein
AL543_RS16735	COG5002	protein histidine kinase activity
AL543_RS16740	COG0745	RESPONSE REGULATOR receiver
AL543_RS16760	COG3335	DDE superfamily endonuclease
AL543_RS16775	COG1129	ABC transporter
AL543_RS16815	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL543_RS16820	COG0372	Belongs to the citrate synthase family
AL543_RS16850	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL543_RS16860	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL543_RS16870	COG0625	glutathione transferase activity
AL543_RS16875	COG3437	response regulator, receiver
AL543_RS16890	COG3335	DDE superfamily endonuclease
AL543_RS16895	COG3706	GGDEF domain
AL543_RS16900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL543_RS16910	COG1254	Belongs to the acylphosphatase family
AL543_RS16915	COG2920	part of a sulfur-relay system
AL543_RS16920	COG0670	Belongs to the BI1 family
AL543_RS16925	COG1126	abc transporter atp-binding protein
AL543_RS16930	COG0765	amino acid transport
AL543_RS16935	COG4597	amino acid ABC transporter
AL543_RS16940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_RS16950	COG0561	phosphatase activity
AL543_RS16955	COG0602	queuosine metabolic process
AL543_RS16960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL543_RS16990	COG3706	GGDEF domain
AL543_RS16995	COG0443	Heat shock 70 kDa protein
AL543_RS17000	COG0443	Heat shock 70 kDa protein
AL543_RS17010	COG3300	MHYT domain
AL543_RS17010	COG5001	Diguanylate cyclase
AL543_RS17030	COG1643	Atp-dependent helicase
AL543_RS17040	COG0754	glutathionylspermidine amidase activity
AL543_RS17055	COG3335	DDE superfamily endonuclease
AL543_RS17085	COG0402	S-adenosylhomocysteine deaminase activity
AL543_RS17090	COG0443	Heat shock 70 kDa protein
AL543_RS17095	COG0583	DNA-binding transcription factor activity
AL543_RS17100	COG0477	Major facilitator Superfamily
AL543_RS17120	COG0513	Belongs to the DEAD box helicase family
AL543_RS17140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL543_RS17180	COG1846	Transcriptional regulator
AL543_RS17200	COG3971	2-oxopent-4-enoate hydratase activity
AL543_RS17220	COG1012	belongs to the aldehyde dehydrogenase family
AL543_RS17235	COG3384	dioxygenase
AL543_RS17240	COG1012	belongs to the aldehyde dehydrogenase family
AL543_RS17250	COG1960	acyl-CoA dehydrogenase activity
AL543_RS17255	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL543_RS17265	COG3501	Rhs element vgr protein
AL543_RS17285	COG1280	lysine exporter protein (LysE YggA)
AL543_RS17290	COG1115	amino acid carrier protein
AL543_RS17305	COG2199	diguanylate cyclase activity
AL543_RS17310	COG2205	protein histidine kinase activity
AL543_RS17310	COG2202	Pas domain
AL543_RS17340	COG1177	transmembrane transport
AL543_RS17350	COG3842	ATPase activity
AL543_RS17355	COG3335	DDE superfamily endonuclease
AL543_RS17375	COG0037	tRNA processing
AL543_RS17380	COG0589	response to stress
AL543_RS17385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL543_RS17400	COG2217	Heavy metal translocating P-type atpase
AL543_RS17410	COG2010	Cytochrome c
AL543_RS17425	COG3278	Belongs to the heme-copper respiratory oxidase family
AL543_RS17440	COG0784	Response regulator, receiver
AL543_RS17440	COG5002	protein histidine kinase activity
AL543_RS17475	COG3120	sequence-specific DNA binding
AL543_RS17480	COG1067	ATP-dependent peptidase activity
AL543_RS17485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL543_RS17500	COG0488	(ABC) transporter
AL543_RS17510	COG0116	Belongs to the methyltransferase superfamily
AL543_RS17510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL543_RS17520	COG0167	dihydroorotate dehydrogenase activity
AL543_RS17535	COG0308	aminopeptidase N
AL543_RS17550	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL543_RS17555	COG1956	GAF domain-containing protein
AL543_RS17565	COG2995	paraquat-inducible protein a
AL543_RS17570	COG3008	intermembrane lipid transfer
AL543_RS17580	COG2996	Protein conserved in bacteria
AL543_RS17595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL543_RS17600	COG1666	GTP binding
AL543_RS17605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL543_RS17610	COG0004	ammonium transporteR
AL543_RS17630	COG0437	4 iron, 4 sulfur cluster binding
AL543_RS17635	COG0243	molybdopterin cofactor binding
AL543_RS17635	COG3383	formate dehydrogenase (NAD+) activity
AL543_RS17665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL543_RS17675	COG0488	(ABC) transporter
AL543_RS17680	COG3852	Histidine kinase
AL543_RS17695	COG4662	Binding-protein-dependent transport system inner membrane component
AL543_RS17700	COG3842	ATPase activity
AL543_RS17705	COG0746	molybdenum cofactor guanylyltransferase activity
AL543_RS17710	COG0303	'Molybdopterin
AL543_RS17720	COG1940	carbohydrate kinase activity
AL543_RS17725	COG3148	PFAM DTW domain containing protein
AL543_RS17735	COG0840	transmembrane signaling receptor activity
AL543_RS17740	COG0791	NLP P60 protein
AL543_RS17750	COG3001	Fructosamine kinase
AL543_RS17760	COG0534	Mate efflux family protein
AL543_RS17770	COG1793	dna ligase
AL543_RS17785	COG0848	biopolymer transport protein
AL543_RS17790	COG0811	peptide transport
AL543_RS17795	COG0811	peptide transport
AL543_RS17810	COG1653	transport
AL543_RS17815	COG1175	transmembrane transport
AL543_RS17820	COG0395	ABC-type sugar transport system, permease component
AL543_RS17825	COG3842	ATPase activity
AL543_RS17835	COG0584	glycerophosphoryl diester phosphodiesterase
AL543_RS17840	COG2731	YhcH YjgK YiaL family protein
AL543_RS17850	COG1609	Transcriptional regulator
AL543_RS17855	COG2723	6-phospho-beta-galactosidase activity
AL543_RS17885	COG0577	efflux transmembrane transporter activity
AL543_RS17890	COG1136	(ABC) transporter
AL543_RS17890	COG0577	efflux transmembrane transporter activity
AL543_RS17895	COG0577	efflux transmembrane transporter activity
AL543_RS17895	COG1136	(ABC) transporter
AL543_RS17905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL543_RS17910	COG1780	Probably involved in ribonucleotide reductase function
AL543_RS17920	COG2166	iron-sulfur cluster assembly
AL543_RS17925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL543_RS17930	COG0719	Fe-S assembly protein
AL543_RS17935	COG0396	ATPase activity
AL543_RS17940	COG0719	Fe-S assembly protein
AL543_RS17945	COG0316	Belongs to the HesB IscA family
AL543_RS17975	COG3097	Belongs to the UPF0267 family
AL543_RS17990	COG0753	catalase activity
AL543_RS18000	COG3064	Membrane
AL543_RS18010	COG2017	converts alpha-aldose to the beta-anomer
AL543_RS18015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL543_RS18020	COG1085	galactose-1-phosphate uridylyltransferase
AL543_RS18055	COG0835	chemotaxis
AL543_RS18055	COG0784	Response regulator, receiver
AL543_RS18065	COG4565	transcriptional regulatory protein
AL543_RS18070	COG3290	protein histidine kinase activity
AL543_RS18085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL543_RS18105	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL543_RS18110	COG3063	Type IV pilus biogenesis stability protein PilW
AL543_RS18125	COG1451	nucleotide metabolic process
AL543_RS18135	COG0583	DNA-binding transcription factor activity
AL543_RS18160	COG1538	Outer membrane efflux protein
AL543_RS18175	COG1748	Saccharopine dehydrogenase
AL543_RS18190	COG3335	DDE superfamily endonuclease
AL543_RS18195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL543_RS18205	COG0577	efflux transmembrane transporter activity
AL543_RS18210	COG4181	ATPase activity
AL543_RS18215	COG0534	Mate efflux family protein
AL543_RS18220	COG0702	epimerase
AL543_RS18230	COG2814	Major facilitator Superfamily
AL543_RS18235	COG1187	pseudouridine synthase activity
AL543_RS18240	COG1061	Type III restriction enzyme res subunit
AL543_RS18260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL543_RS18310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL543_RS18335	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AL543_RS18355	COG4934	collagen metabolic process
AL543_RS18370	COG0784	Response regulator, receiver
AL543_RS18370	COG2205	protein histidine kinase activity
AL543_RS18375	COG2239	Acts as a magnesium transporter
AL543_RS18385	COG0814	amino acid
AL543_RS18390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL543_RS18395	COG1131	(ABC) transporter
AL543_RS18400	COG0842	Transport permease protein
AL543_RS18410	COG3313	Fe-S protein
AL543_RS18420	COG4134	Bacterial extracellular solute-binding protein
AL543_RS18425	COG4135	transport system, permease component
AL543_RS18430	COG4136	ATPase activity
AL543_RS18435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL543_RS18440	COG0564	pseudouridine synthase activity
AL543_RS18445	COG0733	neurotransmitter:sodium symporter activity
AL543_RS18460	COG2818	Glycosylase
AL543_RS18465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL543_RS18480	COG1842	Phage shock protein A
AL543_RS18485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL543_RS18495	COG4168	peptide transport system, permease
AL543_RS18510	COG4172	Belongs to the ABC transporter superfamily
AL543_RS18525	COG1227	inorganic diphosphatase activity
AL543_RS18540	COG1162	GTPase activity
AL543_RS18560	COG0243	molybdopterin cofactor binding
AL543_RS18565	COG3005	denitrification pathway
AL543_RS18570	COG4459	periplasmic nitrate reductase
AL543_RS18575	COG2116	formate transmembrane transporter activity
AL543_RS18590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL543_RS18595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL543_RS18615	COG1607	acyl-coa hydrolase
AL543_RS18620	COG2350	Protein conserved in bacteria
AL543_RS18630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL543_RS18635	COG0583	DNA-binding transcription factor activity
AL543_RS18650	COG0612	Peptidase, M16
AL543_RS18655	COG2203	Gaf domain
AL543_RS18655	COG2199	diguanylate cyclase activity
AL543_RS18655	COG2200	EAL domain
AL543_RS18660	COG1032	radical SAM domain protein
AL543_RS18680	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL543_RS18685	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL543_RS18690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL543_RS18695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL543_RS18700	COG0745	RESPONSE REGULATOR receiver
AL543_RS18705	COG3381	protein complex oligomerization
AL543_RS18715	COG1609	Transcriptional regulator
AL543_RS18720	COG3070	regulator of competence-specific genes
AL543_RS18740	COG0297	glycogen (starch) synthase activity
AL543_RS18745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL543_RS18755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL543_RS18775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL543_RS18780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL543_RS18785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL543_RS18790	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL543_RS18795	COG1960	acyl-CoA dehydrogenase activity
AL543_RS18815	COG1012	belongs to the aldehyde dehydrogenase family
AL543_RS18820	COG1309	transcriptional regulator
AL543_RS18825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL543_RS18835	COG3335	DDE superfamily endonuclease
AL543_RS18840	COG2200	EAL domain
AL543_RS18840	COG2771	luxR family
AL543_RS18850	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL543_RS18855	COG3069	C4-dicarboxylate transmembrane transporter activity
AL543_RS18920	COG4964	Belongs to the GSP D family
AL543_RS18965	COG0641	radical SAM
AL543_RS18970	COG0583	DNA-binding transcription factor activity
AL543_RS19005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_RS19010	COG3537	Alpha-1,2-mannosidase
AL543_RS19020	COG3537	Alpha-1,2-mannosidase
AL543_RS19025	COG3537	Alpha-1,2-mannosidase
AL543_RS19035	COG3537	Alpha-1,2-mannosidase
AL543_RS19045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL543_RS19050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_RS19055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_RS19065	COG2207	Transcriptional regulator
AL543_RS19070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_RS19070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_RS19070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_RS19085	COG5002	protein histidine kinase activity
AL543_RS19085	COG0784	Response regulator, receiver
AL543_RS19095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL543_RS19105	COG2885	chlorophyll binding
AL543_RS19110	COG0823	Involved in the tonB-independent uptake of proteins
AL543_RS19125	COG0811	peptide transport
AL543_RS19130	COG0824	Thioesterase
AL543_RS19140	COG4890	Cyd operon protein YbgT
AL543_RS19145	COG1294	oxidase, subunit
AL543_RS19150	COG1271	oxidase subunit
AL543_RS19160	COG0632	four-way junction helicase activity
AL543_RS19165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL543_RS19170	COG0215	cysteine-tRNA ligase activity
AL543_RS19175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL543_RS19180	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL543_RS19185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL543_RS19190	COG3012	SEC-C Motif Domain Protein
AL543_RS19210	COG1199	ATP-dependent helicase activity
AL543_RS19215	COG0730	response to heat
AL543_RS19220	COG3923	Primosomal replication protein n
AL543_RS19230	COG0840	transmembrane signaling receptor activity
AL543_RS19235	COG0708	Exodeoxyribonuclease III
AL543_RS19240	COG4160	amino acid transport
AL543_RS19265	COG1882	Formate acetyltransferase
AL543_RS19275	COG0840	transmembrane signaling receptor activity
AL543_RS19280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL543_RS19290	COG3013	Belongs to the UPF0304 family
AL543_RS19295	COG2766	serine protein kinase
AL543_RS19300	COG2718	Belongs to the UPF0229 family
AL543_RS19305	COG2719	SpoVR family
AL543_RS19330	COG3385	transposase activity
AL543_RS19335	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL543_RS19340	COG2835	tetraacyldisaccharide 4'-kinase activity
AL543_RS19345	COG1663	tetraacyldisaccharide 4'-kinase activity
AL543_RS19350	COG1132	(ABC) transporter
AL543_RS19355	COG2333	competence protein COMEC
AL543_RS19355	COG0658	competence protein
AL543_RS19365	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL543_RS19370	COG1136	(ABC) transporter
AL543_RS19375	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL543_RS19385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL543_RS19400	COG1252	NADH dehydrogenase
AL543_RS19405	COG3150	esterase
AL543_RS19430	COG0537	adenosine 5'-monophosphoramidase activity
AL543_RS19445	COG2186	Transcriptional regulator
AL543_RS19450	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL543_RS19455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL543_RS19460	COG1674	ftsk spoiiie
AL543_RS19465	COG1522	sequence-specific DNA binding
AL543_RS19470	COG0686	Belongs to the AlaDH PNT family
AL543_RS19480	COG0583	DNA-binding transcription factor activity
AL543_RS19510	COG4608	Belongs to the ABC transporter superfamily
AL543_RS19515	COG0444	Belongs to the ABC transporter superfamily
AL543_RS19520	COG4166	transmembrane transport
AL543_RS19525	COG4239	(ABC) transporter, permease
AL543_RS19530	COG4174	ABC transporter (Permease)
AL543_RS19575	COG2204	response regulator
AL543_RS19585	COG0438	transferase activity, transferring glycosyl groups
AL543_RS19620	COG0438	transferase activity, transferring glycosyl groups
AL543_RS19625	COG1215	transferase activity, transferring glycosyl groups
AL543_RS19630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL543_RS19650	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL543_RS19655	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL543_RS19660	COG0776	regulation of translation
AL543_RS19665	COG0539	negative regulation of cytoplasmic translation
AL543_RS19670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL543_RS19675	COG1555	photosystem II stabilization
AL543_RS19685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL543_RS19690	COG0776	regulation of translation
AL543_RS19695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL543_RS19700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL543_RS19710	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL543_RS19720	COG4191	Histidine kinase
AL543_RS19730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL543_RS19735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL543_RS19740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL543_RS19745	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL543_RS19760	COG3300	MHYT domain
AL543_RS19760	COG5001	Diguanylate cyclase
AL543_RS19770	COG4589	Belongs to the CDS family
AL543_RS19785	COG0671	phosphoesterase, PA-phosphatase related
AL543_RS19800	COG3842	ATPase activity
AL543_RS19830	COG3293	Transposase
AL543_RS19855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL543_RS19865	COG3469	chitinase activity
AL543_RS19865	COG3325	Belongs to the glycosyl hydrolase 18 family
AL543_RS19870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL543_RS19880	COG2951	lytic endotransglycosylase activity
AL543_RS19885	COG3100	YcgL domain-containing protein
AL543_RS19890	COG0850	regulation of cytokinetic process
AL543_RS19895	COG2894	cell division
AL543_RS19900	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL543_RS19905	COG3015	lipoprotein NlpE involved in copper resistance
AL543_RS19925	COG0477	Major facilitator Superfamily
AL543_RS19935	COG1396	sequence-specific DNA binding
AL543_RS19940	COG3135	benzoate transporter
AL543_RS19960	COG0596	Alpha beta hydrolase
AL543_RS19965	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL543_RS19970	COG1169	isochorismate synthase
AL543_RS19975	COG0436	Aminotransferase
AL543_RS19980	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL543_RS19985	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL543_RS19995	COG0705	Rhomboid family
AL543_RS20005	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL543_RS20010	COG0318	PFAM AMP-dependent synthetase and ligase
AL543_RS20015	COG0596	Alpha beta hydrolase
AL543_RS20030	COG1214	PFAM Peptidase M22, glycoprotease
AL543_RS20035	COG1199	ATP-dependent helicase activity
AL543_RS20045	COG0788	formyltetrahydrofolate deformylase activity
AL543_RS20050	COG1902	pentaerythritol trinitrate reductase activity
AL543_RS20050	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL543_RS20055	COG0616	signal peptide processing
AL543_RS20060	COG0252	asparaginase activity
AL543_RS20065	COG3139	Protein of unknown function (DUF1315)
AL543_RS20075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_RS20080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL543_RS20095	COG2226	methyltransferase
AL543_RS20125	COG0784	Response regulator, receiver
AL543_RS20125	COG0835	chemotaxis
AL543_RS20130	COG1940	carbohydrate kinase activity
AL543_RS20140	COG4667	esterase of the alpha-beta hydrolase superfamily
AL543_RS20155	COG0733	neurotransmitter:sodium symporter activity
AL543_RS20170	COG1263	PTS System
AL543_RS20170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_RS20175	COG0084	hydrolase, TatD family'
AL543_RS20180	COG0470	DNA polymerase III
AL543_RS20185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL543_RS20190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL543_RS20195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL543_RS20200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL543_RS20205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL543_RS20210	COG1028	Short-chain dehydrogenase reductase Sdr
AL543_RS20220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL543_RS20225	COG0416	fatty acid biosynthetic process
AL543_RS20230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL543_RS20235	COG1399	metal-binding, possibly nucleic acid-binding protein
AL543_RS20240	COG0424	maF-like protein
AL543_RS20245	COG0564	pseudouridine synthase activity
AL543_RS20260	COG1530	ribonuclease E activity
AL543_RS20265	COG0659	secondary active sulfate transmembrane transporter activity
AL543_RS20275	COG3385	transposase activity
AL543_RS20280	COG1012	belongs to the aldehyde dehydrogenase family
AL543_RS20280	COG1454	alcohol dehydrogenase
AL543_RS20285	COG2095	MarC family integral membrane protein
AL543_RS20290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL543_RS20295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL543_RS20300	COG1757	Na H antiporter
AL543_RS20310	COG3081	Nucleoid-associated protein
AL543_RS20315	COG3082	Protein of unknown function (DUF1414)
AL543_RS20320	COG3083	sulfuric ester hydrolase activity
AL543_RS20340	COG3335	DDE superfamily endonuclease
AL543_RS20350	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AL543_RS20365	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL543_RS20370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL543_RS20375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL543_RS20395	COG2853	Lipoprotein
AL543_RS20405	COG4235	cytochrome complex assembly
AL543_RS20405	COG3088	subunit of a heme lyase
AL543_RS20410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL543_RS20415	COG1138	Cytochrome C-type biogenesis protein
AL543_RS20420	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL543_RS20430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL543_RS20435	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL543_RS20440	COG4133	protoheme IX ABC transporter activity
AL543_RS20450	COG0835	chemotaxis
AL543_RS20460	COG1192	Involved in chromosome partitioning
AL543_RS20465	COG2201	protein-glutamate methylesterase activity
AL543_RS20470	COG2198	Histidine kinase
AL543_RS20470	COG0784	Response regulator, receiver
AL543_RS20470	COG0643	Histidine kinase
AL543_RS20475	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL543_RS20505	COG2062	phosphohistidine phosphatase, SixA
AL543_RS20510	COG1025	Belongs to the peptidase M16 family
AL543_RS20520	COG0018	arginyl-trna synthetase
AL543_RS20540	COG1918	ferrous iron import across plasma membrane
AL543_RS20545	COG4977	sequence-specific DNA binding
AL543_RS20550	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL543_RS20555	COG1121	(ABC) transporter
AL543_RS20560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL543_RS20570	COG0045	succinate-CoA ligase (ADP-forming) activity
AL543_RS20575	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL543_RS20580	COG0567	Dehydrogenase, E1 component
AL543_RS20590	COG1053	succinate dehydrogenase
AL543_RS20595	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL543_RS20605	COG0372	Belongs to the citrate synthase family
AL543_RS20610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL543_RS20620	COG0033	Phosphoglucomutase
AL543_RS20625	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL543_RS20630	COG0596	Alpha beta hydrolase
AL543_RS20645	COG1346	cytolysis
AL543_RS20655	COG0583	DNA-binding transcription factor activity
AL543_RS20665	COG0735	belongs to the Fur family
AL543_RS20670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL543_RS20675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL543_RS20680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL543_RS20690	COG0431	NADPH-dependent FMN reductase
AL543_RS20700	COG3101	peptidyl-lysine hydroxylation
AL543_RS20705	COG2860	membrane
AL543_RS20710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL543_RS20720	COG2890	protein-(glutamine-N5) methyltransferase activity
AL543_RS20725	COG2840	Smr protein MutS2
AL543_RS20740	COG1987	bacterial-type flagellum assembly
AL543_RS20785	COG1317	bacterial-type flagellum organization
AL543_RS20790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL543_RS20800	COG1677	Flagellar hook-basal body complex protein FliE
AL543_RS20820	COG1516	flagellar protein fliS
AL543_RS20830	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL543_RS20835	COG1334	flagellar protein FlaG
AL543_RS20840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_RS20845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_RS20850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_RS20855	COG2837	iron assimilation
AL543_RS20875	COG1393	Belongs to the ArsC family
AL543_RS20885	COG1876	peptidase activity
AL543_RS20895	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL543_RS20910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL543_RS20930	COG4783	chaperone-mediated protein folding
AL543_RS20935	COG1393	Belongs to the ArsC family
AL543_RS20955	COG2233	PERMEase
AL543_RS20960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL543_RS20965	COG0737	Belongs to the 5'-nucleotidase family
AL543_RS20970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL543_RS20975	COG2912	Transglutaminase-like superfamily
AL543_RS20985	COG2890	protein-(glutamine-N5) methyltransferase activity
AL543_RS20990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL543_RS20995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL543_RS21000	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL543_RS21010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL543_RS21015	COG0193	aminoacyl-tRNA hydrolase activity
AL543_RS21020	COG0012	GTP binding
AL543_RS21105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_RS21115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_RS21130	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL543_RS21130	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL543_RS21135	COG1706	bacterial-type flagellum-dependent cell motility
AL543_RS21140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL543_RS21150	COG4787	bacterial-type flagellum-dependent cell motility
AL543_RS21155	COG1749	Flagellar hook protein flgE
AL543_RS21170	COG1815	bacterial-type flagellum-dependent cell motility
AL543_RS21180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL543_RS21185	COG0784	Response regulator, receiver
AL543_RS21185	COG0835	chemotaxis
AL543_RS21235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL543_RS21240	COG2608	mercury ion transmembrane transporter activity
AL543_RS21240	COG2217	Heavy metal translocating P-type atpase
AL543_RS21270	COG2840	Smr protein MutS2
AL543_RS21275	COG1187	pseudouridine synthase activity
AL543_RS21280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL543_RS21285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL543_RS21290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL543_RS21295	COG0121	glutamine amidotransferase
AL543_RS21300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL543_RS21305	COG1960	acyl-CoA dehydrogenase activity
AL543_RS21315	COG1294	oxidase, subunit
AL543_RS21335	COG3220	belongs to the UPF0276 family
AL543_RS21360	COG0328	RNA-DNA hybrid ribonuclease activity
AL543_RS21365	COG2226	methyltransferase
AL543_RS21370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL543_RS21375	COG0741	lytic transglycosylase activity
AL543_RS21375	COG1388	LysM domain
AL543_RS21380	COG3021	interspecies interaction between organisms
AL543_RS21385	COG0347	Belongs to the P(II) protein family
AL543_RS21395	COG0037	tRNA processing
AL543_RS21400	COG0825	malonyl-CoA metabolic process