locus-tag	class	description
vm_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
vm_RS00010	COG0592	DNA-directed DNA polymerase activity
vm_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
vm_RS00020	COG0187	DNA topoisomerase II activity
vm_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
vm_RS00040	COG3977	Valine--pyruvate aminotransferase
vm_RS00045	COG0751	glycine-tRNA ligase activity
vm_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
vm_RS00055	COG2119	membrane
vm_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
vm_RS00080	COG0604	alcohol dehydrogenase
vm_RS00090	COG0129	dihydroxy-acid dehydratase activity
vm_RS00095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
vm_RS00110	COG0606	chelatase, subunit chli
vm_RS00115	COG0204	Acyl-transferase
vm_RS00120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
vm_RS00125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
vm_RS00135	COG3084	Protein conserved in bacteria
vm_RS00145	COG4326	sporulation control protein
vm_RS00150	COG1272	protein, Hemolysin III
vm_RS00160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
vm_RS00165	COG0569	domain protein
vm_RS00170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
vm_RS00170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
vm_RS00180	COG0242	peptide deformylase activity
vm_RS00185	COG1652	LysM domain
vm_RS00190	COG0758	DNA mediated transformation
vm_RS00195	COG2922	Belongs to the Smg family
vm_RS00200	COG0551	DNA topoisomerase type I activity
vm_RS00205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
vm_RS00210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
vm_RS00215	COG0009	L-threonylcarbamoyladenylate synthase
vm_RS00225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
vm_RS00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
vm_RS00280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
vm_RS00285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
vm_RS00295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
vm_RS00300	COG2104	thiamine diphosphate biosynthetic process
vm_RS00305	COG2022	thiamine diphosphate biosynthetic process
vm_RS00310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
vm_RS00315	COG0006	proline dipeptidase activity
vm_RS00315	COG0006	proline dipeptidase activity
vm_RS00335	COG1522	sequence-specific DNA binding
vm_RS00340	COG5002	protein histidine kinase activity
vm_RS00340	COG5001	Diguanylate cyclase
vm_RS00360	COG0589	response to stress
vm_RS00370	COG1528	Iron-storage protein
vm_RS00380	COG2081	HI0933 family
vm_RS00385	COG0840	transmembrane signaling receptor activity
vm_RS00395	COG1322	Protein conserved in bacteria
vm_RS00400	COG2226	methyltransferase
vm_RS00415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
vm_RS00420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
vm_RS00425	COG0805	protein transport
vm_RS00430	COG0534	Mate efflux family protein
vm_RS00440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
vm_RS00445	COG2937	Belongs to the GPAT DAPAT family
vm_RS00450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
vm_RS00455	COG3161	chorismate lyase activity
vm_RS00465	COG1580	Controls the rotational direction of flagella during chemotaxis
vm_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vm_RS00485	COG0084	hydrolase, TatD family'
vm_RS00500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vm_RS00500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vm_RS00525	COG3078	GTPase activator activity
vm_RS00540	COG3071	HemY protein
vm_RS00545	COG2959	enzyme of heme biosynthesis
vm_RS00550	COG1587	Uroporphyrinogen-III synthase
vm_RS00555	COG0181	hydroxymethylbilane synthase activity
vm_RS00565	COG3072	Adenylate cyclase
vm_RS00570	COG1965	Belongs to the frataxin family
vm_RS00580	COG0019	diaminopimelate decarboxylase activity
vm_RS00585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
vm_RS00595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
vm_RS00600	COG1011	Hydrolase
vm_RS00605	COG3287	FIST C domain
vm_RS00605	COG2200	EAL domain
vm_RS00605	COG2199	diguanylate cyclase activity
vm_RS00620	COG0561	phosphatase activity
vm_RS00625	COG2267	carboxylic ester hydrolase activity
vm_RS00630	COG1280	lysine exporter protein (LysE YggA)
vm_RS00635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
vm_RS00640	COG0783	Belongs to the Dps family
vm_RS00675	COG0742	ribosomal rna small subunit methyltransferase
vm_RS00680	COG0552	protein localization to endoplasmic reticulum
vm_RS00685	COG2884	Cell division ATP-binding protein ftsE
vm_RS00690	COG2177	Part of the ABC transporter FtsEX involved in
vm_RS00695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
vm_RS00705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vm_RS00720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
vm_RS00725	COG4206	TonB-dependent receptor
vm_RS00735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
vm_RS00800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
vm_RS00805	COG3300	MHYT domain
vm_RS00805	COG5001	Diguanylate cyclase
vm_RS00815	COG3852	Histidine kinase
vm_RS00825	COG0174	glutamine synthetase
vm_RS00835	COG1217	gtp-binding protein TYPA
vm_RS00845	COG1295	ribonuclease BN
vm_RS00850	COG1490	D-aminoacyl-tRNA deacylase activity
vm_RS00855	COG0456	acetyltransferase
vm_RS00865	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
vm_RS00870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
vm_RS00875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
vm_RS00880	COG3031	protein transport across the cell outer membrane
vm_RS00890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vm_RS00895	COG1459	type II secretion system
vm_RS00900	COG2165	general secretion pathway protein
vm_RS00905	COG2165	general secretion pathway protein
vm_RS00910	COG2165	general secretion pathway protein
vm_RS00915	COG4795	General secretion pathway protein
vm_RS00920	COG3156	type II secretion system protein K
vm_RS00925	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
vm_RS00930	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
vm_RS00940	COG1218	3'(2'),5'-bisphosphate nucleotidase
vm_RS00945	COG0494	nUDIX hydrolase
vm_RS00955	COG1040	competence protein
vm_RS00960	COG0596	Alpha beta hydrolase
vm_RS00970	COG2183	response to ionizing radiation
vm_RS01000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
vm_RS01070	COG1061	Type III restriction enzyme res subunit
vm_RS01080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vm_RS01100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vm_RS01115	COG1129	ABC transporter
vm_RS01120	COG1172	Belongs to the binding-protein-dependent transport system permease family
vm_RS01125	COG1472	Belongs to the glycosyl hydrolase 3 family
vm_RS01145	COG2233	PERMEase
vm_RS01150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
vm_RS01155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
vm_RS01160	COG1758	RNA polymerase activity
vm_RS01165	COG0194	GDP metabolic process
vm_RS01170	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
vm_RS01175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
vm_RS01190	COG3423	Transcriptional regulator
vm_RS01195	COG2801	Transposase and inactivated derivatives
vm_RS01200	COG2842	Transposition protein
vm_RS01375	COG4397	Mu-like prophage major head subunit gpT
vm_RS01385	COG4387	Mu-like prophage protein GP36
vm_RS01415	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
vm_RS01435	COG4384	Bacteriophage Mu Gp45 protein
vm_RS01445	COG3299	homolog of phage Mu protein gp47
vm_RS01450	COG3778	Protein conserved in bacteria
vm_RS01475	COG4232	protein-disulfide reductase activity
vm_RS01480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
vm_RS01485	COG1027	Aspartate ammonia-lyase
vm_RS01495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
vm_RS01505	COG2205	protein histidine kinase activity
vm_RS01510	COG0745	RESPONSE REGULATOR receiver
vm_RS01520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
vm_RS01525	COG0205	6-phosphofructokinase activity
vm_RS01530	COG1494	fructose-1,6-bisphosphatase
vm_RS01535	COG3074	FtsZ-dependent cytokinesis
vm_RS01540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
vm_RS01545	COG0460	homoserine dehydrogenase
vm_RS01545	COG0527	aspartate kinase activity
vm_RS01550	COG0626	cystathionine gamma-synthase activity
vm_RS01555	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
vm_RS01560	COG0281	malic enzyme
vm_RS01565	COG0254	rRNA binding
vm_RS01570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
vm_RS01575	COG1609	Transcriptional regulator
vm_RS01585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
vm_RS01590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
vm_RS01595	COG1575	Belongs to the MenA family. Type 1 subfamily
vm_RS01600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
vm_RS01605	COG0534	Mate efflux family protein
vm_RS01610	COG0149	triose-phosphate isomerase activity
vm_RS01635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
vm_RS01640	COG0459	protein refolding
vm_RS01650	COG1509	lysine 2,3-aminomutase activity
vm_RS01655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
vm_RS01665	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
vm_RS01670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
vm_RS01675	COG1053	succinate dehydrogenase
vm_RS01680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
vm_RS01685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vm_RS01690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
vm_RS01695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
vm_RS01700	COG1045	serine acetyltransferase
vm_RS01710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
vm_RS01715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
vm_RS01720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
vm_RS01725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
vm_RS01730	COG0137	argininosuccinate synthase activity
vm_RS01735	COG0165	Argininosuccinate lyase
vm_RS01750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
vm_RS01750	COG0678	peroxiredoxin activity
vm_RS01760	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
vm_RS01790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
vm_RS01795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
vm_RS01805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
vm_RS01810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
vm_RS01815	COG0546	phosphoglycolate phosphatase activity
vm_RS01820	COG0180	Tryptophanyl-tRNA synthetase
vm_RS01835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
vm_RS01840	COG0446	pyridine nucleotide-disulphide oxidoreductase
vm_RS01850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
vm_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
vm_RS01875	COG3954	Phosphoribulokinase
vm_RS01885	COG0429	hydrolase of the alpha beta-hydrolase fold
vm_RS01895	COG0488	(ABC) transporter
vm_RS01900	COG2249	NAD(P)H dehydrogenase (quinone) activity
vm_RS01915	COG1047	Peptidyl-prolyl cis-trans
vm_RS01930	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
vm_RS01935	COG3083	sulfuric ester hydrolase activity
vm_RS01940	COG0557	exoribonuclease II activity
vm_RS01945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
vm_RS01950	COG0051	transcription antitermination factor activity, RNA binding
vm_RS01955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
vm_RS01960	COG0088	Forms part of the polypeptide exit tunnel
vm_RS01965	COG0089	rRNA binding
vm_RS01970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
vm_RS01975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
vm_RS01980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
vm_RS01985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
vm_RS01990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
vm_RS01995	COG0255	Belongs to the universal ribosomal protein uL29 family
vm_RS02000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
vm_RS02005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
vm_RS02010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
vm_RS02015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
vm_RS02020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
vm_RS02025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
vm_RS02035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
vm_RS02040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
vm_RS02045	COG1841	ribosomal large subunit assembly
vm_RS02055	COG0201	protein transport
vm_RS02060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
vm_RS02065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
vm_RS02070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
vm_RS02075	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
vm_RS02080	COG0202	RNA polymerase activity
vm_RS02085	COG0203	ribosomal protein L17
vm_RS02095	COG0545	Peptidyl-prolyl cis-trans isomerase
vm_RS02100	COG3061	Opacity-associated protein A
vm_RS02100	COG3266	domain, Protein
vm_RS02105	COG0697	spore germination
vm_RS02110	COG2153	protein acetylation
vm_RS02115	COG0513	Belongs to the DEAD box helicase family
vm_RS02130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
vm_RS02130	COG1648	precorrin-2 dehydrogenase activity
vm_RS02135	COG0175	sulfate reduction
vm_RS02140	COG2895	sulfate adenylyltransferase (ATP) activity
vm_RS02145	COG0529	Catalyzes the synthesis of activated sulfate
vm_RS02165	COG1136	(ABC) transporter
vm_RS02180	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
vm_RS02185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vm_RS02190	COG0729	surface antigen
vm_RS02195	COG2911	Protein conserved in bacteria
vm_RS02200	COG2105	PFAM AIG2 family protein
vm_RS02210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
vm_RS02215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
vm_RS02225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
vm_RS02230	COG0163	prenyltransferase activity
vm_RS02245	COG1178	ABC-type Fe3 transport system permease component
vm_RS02250	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
vm_RS02255	COG3028	Belongs to the UPF0307 family
vm_RS02260	COG0312	modulator of DNA gyrase
vm_RS02265	COG2239	Acts as a magnesium transporter
vm_RS02270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
vm_RS02275	COG1660	Displays ATPase and GTPase activities
vm_RS02280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
vm_RS02285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
vm_RS02295	COG1137	ATPase activity
vm_RS02300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
vm_RS02315	COG0517	IMP dehydrogenase activity
vm_RS02315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
vm_RS02330	COG1127	ABC transporter
vm_RS02335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
vm_RS02340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
vm_RS02345	COG2854	intermembrane phospholipid transfer
vm_RS02355	COG5007	Belongs to the BolA IbaG family
vm_RS02360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
vm_RS02365	COG0204	Acyl-transferase
vm_RS02370	COG0251	oxidation-reduction process
vm_RS02380	COG0540	Belongs to the ATCase OTCase family
vm_RS02390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
vm_RS02400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
vm_RS02405	COG0564	pseudouridine synthase activity
vm_RS02410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
vm_RS02415	COG4269	membrane
vm_RS02425	COG0525	valine-tRNA ligase activity
vm_RS02430	COG2927	DNA polymerase III (CHI subunit)
vm_RS02435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
vm_RS02440	COG0795	lipopolysaccharide-transporting ATPase activity
vm_RS02445	COG0795	lipopolysaccharide-transporting ATPase activity
vm_RS02460	COG3437	response regulator, receiver
vm_RS02500	COG0066	3-isopropylmalate dehydratase activity
vm_RS02505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
vm_RS02510	COG0473	3-isopropylmalate dehydrogenase activity
vm_RS02525	COG0671	phosphoesterase, PA-phosphatase related
vm_RS02535	COG0583	DNA-binding transcription factor activity
vm_RS02540	COG1022	Amp-dependent synthetase and ligase
vm_RS02545	COG0028	Belongs to the TPP enzyme family
vm_RS02550	COG0440	acetolactate synthase activity
vm_RS02555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
vm_RS02560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
vm_RS02565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
vm_RS02575	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
vm_RS02580	COG3079	Belongs to the UPF0149 family
vm_RS02585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vm_RS02590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vm_RS02605	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
vm_RS02615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
vm_RS02625	COG1595	DNA-templated transcription, initiation
vm_RS02640	COG3086	response to oxidative stress
vm_RS02645	COG0481	GTPase activity
vm_RS02655	COG0571	ribonuclease III activity
vm_RS02660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
vm_RS02665	COG1381	Involved in DNA repair and RecF pathway recombination
vm_RS02670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
vm_RS02675	COG0736	holo-[acyl-carrier-protein] synthase activity
vm_RS02695	COG2205	protein histidine kinase activity
vm_RS02695	COG3437	response regulator, receiver
vm_RS02695	COG3850	Histidine kinase
vm_RS02695	COG4999	Histidine kinase
vm_RS02705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
vm_RS02710	COG3956	TIGRFAM MazG family protein
vm_RS02720	COG0504	CTP synthase activity
vm_RS02725	COG0148	phosphopyruvate hydratase activity
vm_RS02735	COG0814	amino acid
vm_RS02745	COG0617	tRNA 3'-terminal CCA addition
vm_RS02750	COG3267	Type II secretory pathway component ExeA
vm_RS02750	COG3409	Peptidoglycan-binding domain 1 protein
vm_RS02760	COG4991	sh3 domain protein
vm_RS02765	COG0306	phosphate transporter
vm_RS02770	COG1392	Phosphate transport regulator
vm_RS02775	COG3025	triphosphatase activity
vm_RS02780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vm_RS02790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
vm_RS02800	COG1538	Outer membrane efflux protein
vm_RS02805	COG0494	nUDIX hydrolase
vm_RS02810	COG3151	Protein conserved in bacteria
vm_RS02820	COG3150	esterase
vm_RS02825	COG0187	DNA topoisomerase II activity
vm_RS02830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
vm_RS02840	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
vm_RS02845	COG0237	dephospho-CoA kinase activity
vm_RS02855	COG1459	type II secretion system
vm_RS02860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vm_RS02880	COG0716	FMN binding
vm_RS02885	COG4974	Belongs to the 'phage' integrase family
vm_RS02890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
vm_RS02895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
vm_RS02900	COG1227	inorganic diphosphatase activity
vm_RS02905	COG0737	Belongs to the 5'-nucleotidase family
vm_RS02915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
vm_RS02920	COG0508	dehydrogenase complex catalyzes the overall conversion of
vm_RS02925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vm_RS02940	COG3116	cell division
vm_RS02945	COG0768	penicillin binding
vm_RS02950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
vm_RS02955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
vm_RS02965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
vm_RS02970	COG0772	Belongs to the SEDS family
vm_RS02975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
vm_RS02980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
vm_RS02985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
vm_RS02990	COG0849	cell division
vm_RS02995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
vm_RS03000	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
vm_RS03010	COG0653	protein targeting
vm_RS03015	COG0494	nUDIX hydrolase
vm_RS03020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
vm_RS03025	COG0505	Belongs to the CarA family
vm_RS03030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
vm_RS03035	COG0730	response to heat
vm_RS03040	COG0583	DNA-binding transcription factor activity
vm_RS03045	COG2860	membrane
vm_RS03050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
vm_RS03060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
vm_RS03070	COG0493	'glutamate synthase
vm_RS03075	COG0070	glutamate synthase
vm_RS03075	COG0069	glutamate synthase activity
vm_RS03075	COG0067	glutamate synthase
vm_RS03085	COG0070	glutamate synthase
vm_RS03085	COG0069	glutamate synthase activity
vm_RS03085	COG0067	glutamate synthase
vm_RS03090	COG1242	4 iron, 4 sulfur cluster binding
vm_RS03095	COG3706	GGDEF domain
vm_RS03095	COG2203	Gaf domain
vm_RS03095	COG4251	negative regulation of phosphorylation
vm_RS03095	COG5001	Diguanylate cyclase
vm_RS03100	COG5002	protein histidine kinase activity
vm_RS03100	COG2198	Histidine kinase
vm_RS03100	COG0784	Response regulator, receiver
vm_RS03105	COG0745	RESPONSE REGULATOR receiver
vm_RS03115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
vm_RS03130	COG0083	homoserine kinase activity
vm_RS03135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
vm_RS03140	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
vm_RS03145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
vm_RS03150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
vm_RS03160	COG2801	Transposase and inactivated derivatives
vm_RS03170	COG1115	amino acid carrier protein
vm_RS03175	COG3022	response to hydroperoxide
vm_RS03180	COG0084	hydrolase, TatD family'
vm_RS03185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
vm_RS03195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
vm_RS03200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
vm_RS03205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
vm_RS03210	COG0813	purine-nucleoside phosphorylase activity
vm_RS03220	COG0560	Phosphoserine phosphatase
vm_RS03230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
vm_RS03235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
vm_RS03240	COG0583	DNA-binding transcription factor activity
vm_RS03250	COG1022	Amp-dependent synthetase and ligase
vm_RS03265	COG3250	beta-galactosidase activity
vm_RS03270	COG1609	Transcriptional regulator
vm_RS03275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vm_RS03290	COG0189	ligase activity
vm_RS03290	COG0569	domain protein
vm_RS03305	COG2171	N-acyltransferase activity
vm_RS03315	COG3141	response to X-ray
vm_RS03330	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
vm_RS03335	COG1074	ATP-dependent DNA helicase activity
vm_RS03340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
vm_RS03355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
vm_RS03355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
vm_RS03365	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
vm_RS03370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
vm_RS03375	COG2166	iron-sulfur cluster assembly
vm_RS03380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
vm_RS03385	COG0693	protein deglycase activity
vm_RS03390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
vm_RS03405	COG1595	DNA-templated transcription, initiation
vm_RS03415	COG2211	Major facilitator Superfamily
vm_RS03420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
vm_RS03430	COG2813	Specifically methylates the guanine in position
vm_RS03435	COG0271	Belongs to the BolA IbaG family
vm_RS03440	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vm_RS03445	COG1805	sodium ion transport
vm_RS03450	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vm_RS03455	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vm_RS03460	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
vm_RS03465	COG2871	sodium ion transport
vm_RS03470	COG1477	protein flavinylation
vm_RS03495	COG0733	neurotransmitter:sodium symporter activity
vm_RS03505	COG0189	ligase activity
vm_RS03510	COG4067	protein conserved in archaea
vm_RS03510	COG0189	ligase activity
vm_RS03515	COG2195	Cleaves the N-terminal amino acid of tripeptides
vm_RS03520	COG2252	PERMEase
vm_RS03525	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
vm_RS03530	COG1073	alpha beta
vm_RS03540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
vm_RS03545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
vm_RS03550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
vm_RS03555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
vm_RS03555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
vm_RS03570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
vm_RS03575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
vm_RS03580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
vm_RS03585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
vm_RS03595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
vm_RS03600	COG0024	Methionine aminopeptidase
vm_RS03605	COG0052	Belongs to the universal ribosomal protein uS2 family
vm_RS03610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
vm_RS03615	COG0528	UMP kinase activity
vm_RS03620	COG0233	cytoplasmic translational termination
vm_RS03625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
vm_RS03630	COG0575	Belongs to the CDS family
vm_RS03635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
vm_RS03640	COG0750	zinc metalloprotease
vm_RS03650	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
vm_RS03655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vm_RS03660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
vm_RS03665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vm_RS03670	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vm_RS03675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
vm_RS03680	COG0587	DNA-directed DNA polymerase activity
vm_RS03685	COG0825	malonyl-CoA metabolic process
vm_RS03690	COG0037	tRNA processing
vm_RS03700	COG0347	Belongs to the P(II) protein family
vm_RS03705	COG3021	interspecies interaction between organisms
vm_RS03710	COG0741	lytic transglycosylase activity
vm_RS03710	COG1388	LysM domain
vm_RS03715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
vm_RS03720	COG2226	methyltransferase
vm_RS03725	COG0328	RNA-DNA hybrid ribonuclease activity
vm_RS03740	COG1960	acyl-CoA dehydrogenase activity
vm_RS03745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
vm_RS03750	COG0121	glutamine amidotransferase
vm_RS03755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
vm_RS03760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
vm_RS03765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
vm_RS03770	COG1187	pseudouridine synthase activity
vm_RS03775	COG2840	Smr protein MutS2
vm_RS03805	COG2217	Heavy metal translocating P-type atpase
vm_RS03805	COG2608	mercury ion transmembrane transporter activity
vm_RS03810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
vm_RS03860	COG0835	chemotaxis
vm_RS03860	COG0784	Response regulator, receiver
vm_RS03865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
vm_RS03870	COG1815	bacterial-type flagellum-dependent cell motility
vm_RS03885	COG1749	Flagellar hook protein flgE
vm_RS03890	COG4787	bacterial-type flagellum-dependent cell motility
vm_RS03900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
vm_RS03905	COG1706	bacterial-type flagellum-dependent cell motility
vm_RS03910	COG3951	Flagellar rod assembly protein muramidase FlgJ
vm_RS03910	COG1705	Flagellar rod assembly protein muramidase FlgJ
vm_RS03925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vm_RS03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vm_RS04015	COG0012	GTP binding
vm_RS04020	COG0193	aminoacyl-tRNA hydrolase activity
vm_RS04025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
vm_RS04030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
vm_RS04035	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
vm_RS04040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
vm_RS04045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
vm_RS04050	COG2890	protein-(glutamine-N5) methyltransferase activity
vm_RS04060	COG2912	Transglutaminase-like superfamily
vm_RS04065	COG2877	3-deoxy-8-phosphooctulonate synthase activity
vm_RS04070	COG0737	Belongs to the 5'-nucleotidase family
vm_RS04075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
vm_RS04080	COG2233	PERMEase
vm_RS04100	COG1393	Belongs to the ArsC family
vm_RS04105	COG4783	chaperone-mediated protein folding
vm_RS04145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
vm_RS04170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
vm_RS04185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
vm_RS04195	COG1876	peptidase activity
vm_RS04205	COG1393	Belongs to the ArsC family
vm_RS04225	COG2837	iron assimilation
vm_RS04230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vm_RS04235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vm_RS04240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vm_RS04245	COG1334	flagellar protein FlaG
vm_RS04250	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
vm_RS04260	COG1516	flagellar protein fliS
vm_RS04280	COG1677	Flagellar hook-basal body complex protein FliE
vm_RS04290	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
vm_RS04295	COG1317	bacterial-type flagellum organization
vm_RS04340	COG1987	bacterial-type flagellum assembly
vm_RS04355	COG2840	Smr protein MutS2
vm_RS04360	COG2890	protein-(glutamine-N5) methyltransferase activity
vm_RS04370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
vm_RS04375	COG2860	membrane
vm_RS04380	COG3101	peptidyl-lysine hydroxylation
vm_RS04390	COG0431	NADPH-dependent FMN reductase
vm_RS04395	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
vm_RS04395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vm_RS04400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
vm_RS04405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
vm_RS04410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
vm_RS04420	COG0735	belongs to the Fur family
vm_RS04430	COG0583	DNA-binding transcription factor activity
vm_RS04440	COG1346	cytolysis
vm_RS04455	COG0596	Alpha beta hydrolase
vm_RS04460	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
vm_RS04465	COG0033	Phosphoglucomutase
vm_RS04475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
vm_RS04480	COG0372	Belongs to the citrate synthase family
vm_RS04490	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
vm_RS04495	COG1053	succinate dehydrogenase
vm_RS04505	COG0567	Dehydrogenase, E1 component
vm_RS04510	COG0508	dehydrogenase complex catalyzes the overall conversion of
vm_RS04515	COG0045	succinate-CoA ligase (ADP-forming) activity
vm_RS04525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
vm_RS04530	COG1121	(ABC) transporter
vm_RS04535	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
vm_RS04540	COG4977	sequence-specific DNA binding
vm_RS04545	COG1918	ferrous iron import across plasma membrane
vm_RS04570	COG0018	arginyl-trna synthetase
vm_RS04580	COG1025	Belongs to the peptidase M16 family
vm_RS04585	COG2062	phosphohistidine phosphatase, SixA
vm_RS04615	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
vm_RS04620	COG2198	Histidine kinase
vm_RS04620	COG0784	Response regulator, receiver
vm_RS04620	COG0643	Histidine kinase
vm_RS04625	COG2201	protein-glutamate methylesterase activity
vm_RS04630	COG1192	Involved in chromosome partitioning
vm_RS04640	COG0835	chemotaxis
vm_RS04650	COG4133	protoheme IX ABC transporter activity
vm_RS04655	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
vm_RS04660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
vm_RS04670	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
vm_RS04675	COG1138	Cytochrome C-type biogenesis protein
vm_RS04680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
vm_RS04685	COG3088	subunit of a heme lyase
vm_RS04685	COG4235	cytochrome complex assembly
vm_RS04695	COG2853	Lipoprotein
vm_RS04715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
vm_RS04720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
vm_RS04725	COG0123	including yeast histone deacetylase and acetoin utilization protein
vm_RS04740	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
vm_RS04760	COG3083	sulfuric ester hydrolase activity
vm_RS04765	COG3082	Protein of unknown function (DUF1414)
vm_RS04770	COG3081	Nucleoid-associated protein
vm_RS04780	COG1757	Na H antiporter
vm_RS04785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
vm_RS04790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vm_RS04795	COG2095	MarC family integral membrane protein
vm_RS04800	COG1012	belongs to the aldehyde dehydrogenase family
vm_RS04800	COG1454	alcohol dehydrogenase
vm_RS04810	COG0659	secondary active sulfate transmembrane transporter activity
vm_RS04815	COG1530	ribonuclease E activity
vm_RS04825	COG0564	pseudouridine synthase activity
vm_RS04830	COG0424	maF-like protein
vm_RS04835	COG1399	metal-binding, possibly nucleic acid-binding protein
vm_RS04840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
vm_RS04845	COG0416	fatty acid biosynthetic process
vm_RS04850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
vm_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
vm_RS04865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
vm_RS04870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
vm_RS04875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
vm_RS04880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
vm_RS04885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
vm_RS04890	COG0470	DNA polymerase III
vm_RS04895	COG0084	hydrolase, TatD family'
vm_RS04900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vm_RS04900	COG1263	PTS System
vm_RS04910	COG0733	neurotransmitter:sodium symporter activity
vm_RS04920	COG4667	esterase of the alpha-beta hydrolase superfamily
vm_RS04930	COG1940	carbohydrate kinase activity
vm_RS04935	COG0784	Response regulator, receiver
vm_RS04935	COG0835	chemotaxis
vm_RS04965	COG2226	methyltransferase
vm_RS04980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
vm_RS04985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vm_RS04995	COG3139	Protein of unknown function (DUF1315)
vm_RS05000	COG0252	asparaginase activity
vm_RS05005	COG0616	signal peptide processing
vm_RS05010	COG0446	pyridine nucleotide-disulphide oxidoreductase
vm_RS05010	COG1902	pentaerythritol trinitrate reductase activity
vm_RS05015	COG0788	formyltetrahydrofolate deformylase activity
vm_RS05025	COG1199	ATP-dependent helicase activity
vm_RS05030	COG1214	PFAM Peptidase M22, glycoprotease
vm_RS05045	COG0596	Alpha beta hydrolase
vm_RS05050	COG0318	PFAM AMP-dependent synthetase and ligase
vm_RS05055	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
vm_RS05065	COG0705	Rhomboid family
vm_RS05075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
vm_RS05080	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
vm_RS05085	COG0436	Aminotransferase
vm_RS05090	COG1169	isochorismate synthase
vm_RS05095	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
vm_RS05100	COG0596	Alpha beta hydrolase
vm_RS05120	COG3135	benzoate transporter
vm_RS05125	COG1396	sequence-specific DNA binding
vm_RS05130	COG0840	transmembrane signaling receptor activity
vm_RS05135	COG0477	Major facilitator Superfamily
vm_RS05155	COG3015	lipoprotein NlpE involved in copper resistance
vm_RS05160	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
vm_RS05165	COG2894	cell division
vm_RS05170	COG0850	regulation of cytokinetic process
vm_RS05175	COG3100	YcgL domain-containing protein
vm_RS05180	COG2951	lytic endotransglycosylase activity
vm_RS05190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
vm_RS05195	COG3469	chitinase activity
vm_RS05195	COG3325	Belongs to the glycosyl hydrolase 18 family
vm_RS05205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
vm_RS05225	COG0671	phosphoesterase, PA-phosphatase related
vm_RS05245	COG4589	Belongs to the CDS family
vm_RS05255	COG3300	MHYT domain
vm_RS05255	COG5001	Diguanylate cyclase
vm_RS05270	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
vm_RS05275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
vm_RS05280	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
vm_RS05285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
vm_RS05295	COG4191	Histidine kinase
vm_RS05305	COG0544	peptidyl-prolyl cis-trans isomerase activity
vm_RS05315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
vm_RS05320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
vm_RS05325	COG0776	regulation of translation
vm_RS05330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
vm_RS05335	COG1555	photosystem II stabilization
vm_RS05345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
vm_RS05350	COG0539	negative regulation of cytoplasmic translation
vm_RS05355	COG0776	regulation of translation
vm_RS05360	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
vm_RS05365	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
vm_RS05385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
vm_RS05390	COG1215	transferase activity, transferring glycosyl groups
vm_RS05395	COG0438	transferase activity, transferring glycosyl groups
vm_RS05430	COG0438	transferase activity, transferring glycosyl groups
vm_RS05440	COG2204	response regulator
vm_RS05485	COG0601	transmembrane transport
vm_RS05490	COG4239	(ABC) transporter, permease
vm_RS05495	COG4166	transmembrane transport
vm_RS05500	COG0444	Belongs to the ABC transporter superfamily
vm_RS05505	COG4608	Belongs to the ABC transporter superfamily
vm_RS05530	COG0583	DNA-binding transcription factor activity
vm_RS05540	COG0686	Belongs to the AlaDH PNT family
vm_RS05545	COG1522	sequence-specific DNA binding
vm_RS05550	COG1674	ftsk spoiiie
vm_RS05555	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
vm_RS05560	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
vm_RS05565	COG2186	Transcriptional regulator
vm_RS05580	COG0537	adenosine 5'-monophosphoramidase activity
vm_RS05605	COG3150	esterase
vm_RS05610	COG1252	NADH dehydrogenase
vm_RS05625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
vm_RS05635	COG4591	ABC-type transport system involved in lipoprotein release permease component
vm_RS05640	COG1136	(ABC) transporter
vm_RS05645	COG4591	ABC-type transport system involved in lipoprotein release permease component
vm_RS05655	COG0658	competence protein
vm_RS05655	COG2333	competence protein COMEC
vm_RS05660	COG1132	(ABC) transporter
vm_RS05665	COG1663	tetraacyldisaccharide 4'-kinase activity
vm_RS05670	COG2835	tetraacyldisaccharide 4'-kinase activity
vm_RS05675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
vm_RS05700	COG2719	SpoVR family
vm_RS05705	COG2718	Belongs to the UPF0229 family
vm_RS05710	COG2766	serine protein kinase
vm_RS05715	COG3013	Belongs to the UPF0304 family
vm_RS05725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
vm_RS05730	COG0840	transmembrane signaling receptor activity
vm_RS05740	COG1882	Formate acetyltransferase
vm_RS05765	COG4160	amino acid transport
vm_RS05770	COG0708	Exodeoxyribonuclease III
vm_RS05775	COG0840	transmembrane signaling receptor activity
vm_RS05785	COG3923	Primosomal replication protein n
vm_RS05790	COG0730	response to heat
vm_RS05795	COG1199	ATP-dependent helicase activity
vm_RS05805	COG3012	SEC-C Motif Domain Protein
vm_RS05810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
vm_RS05815	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
vm_RS05820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
vm_RS05825	COG0215	cysteine-tRNA ligase activity
vm_RS05830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
vm_RS05835	COG0632	four-way junction helicase activity
vm_RS05845	COG1271	oxidase subunit
vm_RS05850	COG1294	oxidase, subunit
vm_RS05855	COG4890	Cyd operon protein YbgT
vm_RS05865	COG0824	Thioesterase
vm_RS05870	COG0811	peptide transport
vm_RS05885	COG0823	Involved in the tonB-independent uptake of proteins
vm_RS05890	COG2885	chlorophyll binding
vm_RS05900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
vm_RS05910	COG0784	Response regulator, receiver
vm_RS05910	COG5002	protein histidine kinase activity
vm_RS05925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vm_RS05925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vm_RS05925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
vm_RS05930	COG2207	Transcriptional regulator
vm_RS05940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vm_RS05945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vm_RS05950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
vm_RS05960	COG3537	Alpha-1,2-mannosidase
vm_RS05965	COG3537	Alpha-1,2-mannosidase
vm_RS05975	COG3537	Alpha-1,2-mannosidase
vm_RS05980	COG3537	Alpha-1,2-mannosidase
vm_RS05985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
vm_RS06005	COG2801	Transposase and inactivated derivatives
vm_RS06050	COG1475	DNA binding
vm_RS06055	COG3969	phosphoadenosine phosphosulfate
vm_RS06060	COG4932	domain protein
vm_RS06060	COG5492	domain, Protein
vm_RS06085	COG0583	DNA-binding transcription factor activity
vm_RS06190	COG3250	beta-galactosidase activity
vm_RS06205	COG3069	C4-dicarboxylate transmembrane transporter activity
vm_RS06210	COG2195	Cleaves the N-terminal amino acid of tripeptides
vm_RS06220	COG2771	luxR family
vm_RS06220	COG2200	EAL domain
vm_RS06230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vm_RS06235	COG1309	transcriptional regulator
vm_RS06240	COG1012	belongs to the aldehyde dehydrogenase family
vm_RS06260	COG1960	acyl-CoA dehydrogenase activity
vm_RS06265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
vm_RS06270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
vm_RS06275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
vm_RS06280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
vm_RS06300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
vm_RS06310	COG0297	glycogen (starch) synthase activity
vm_RS06335	COG1609	Transcriptional regulator
vm_RS06340	COG3381	protein complex oligomerization
vm_RS06345	COG0745	RESPONSE REGULATOR receiver
vm_RS06355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
vm_RS06360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
vm_RS06365	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
vm_RS06370	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
vm_RS06390	COG1032	radical SAM domain protein
vm_RS06395	COG2200	EAL domain
vm_RS06395	COG2199	diguanylate cyclase activity
vm_RS06395	COG2203	Gaf domain
vm_RS06400	COG0612	Peptidase, M16
vm_RS06415	COG0583	DNA-binding transcription factor activity
vm_RS06420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
vm_RS06430	COG2350	Protein conserved in bacteria
vm_RS06435	COG1607	acyl-coa hydrolase
vm_RS06455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
vm_RS06460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
vm_RS06470	COG2116	formate transmembrane transporter activity
vm_RS06480	COG4459	periplasmic nitrate reductase
vm_RS06485	COG3005	denitrification pathway
vm_RS06490	COG0243	molybdopterin cofactor binding
vm_RS06495	COG2801	Transposase and inactivated derivatives
vm_RS06505	COG1162	GTPase activity
vm_RS06515	COG1227	inorganic diphosphatase activity
vm_RS06530	COG4172	Belongs to the ABC transporter superfamily
vm_RS06545	COG4168	peptide transport system, permease
vm_RS06555	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
vm_RS06560	COG1842	Phage shock protein A
vm_RS06575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
vm_RS06580	COG0519	Catalyzes the synthesis of GMP from XMP
vm_RS06595	COG0733	neurotransmitter:sodium symporter activity
vm_RS06600	COG0564	pseudouridine synthase activity
vm_RS06605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
vm_RS06610	COG4136	ATPase activity
vm_RS06615	COG4135	transport system, permease component
vm_RS06620	COG4134	Bacterial extracellular solute-binding protein
vm_RS06630	COG3313	Fe-S protein
vm_RS06640	COG0842	Transport permease protein
vm_RS06645	COG1131	(ABC) transporter
vm_RS06650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vm_RS06655	COG0814	amino acid
vm_RS06665	COG2239	Acts as a magnesium transporter
vm_RS06670	COG2205	protein histidine kinase activity
vm_RS06670	COG0784	Response regulator, receiver
vm_RS06685	COG4934	collagen metabolic process
vm_RS06705	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
vm_RS06715	COG0840	transmembrane signaling receptor activity
vm_RS06735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vm_RS06750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
vm_RS06770	COG1061	Type III restriction enzyme res subunit
vm_RS06775	COG1187	pseudouridine synthase activity
vm_RS06790	COG0702	epimerase
vm_RS06795	COG0534	Mate efflux family protein
vm_RS06800	COG4181	ATPase activity
vm_RS06805	COG0577	efflux transmembrane transporter activity
vm_RS06815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
vm_RS06830	COG1748	Saccharopine dehydrogenase
vm_RS06845	COG1538	Outer membrane efflux protein
vm_RS06870	COG0583	DNA-binding transcription factor activity
vm_RS06880	COG1451	nucleotide metabolic process
vm_RS06895	COG3063	Type IV pilus biogenesis stability protein PilW
vm_RS06900	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
vm_RS06920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vm_RS06935	COG3290	protein histidine kinase activity
vm_RS06940	COG4565	transcriptional regulatory protein
vm_RS06950	COG0835	chemotaxis
vm_RS06950	COG0784	Response regulator, receiver
vm_RS06985	COG1085	galactose-1-phosphate uridylyltransferase
vm_RS06990	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
vm_RS06995	COG2017	converts alpha-aldose to the beta-anomer
vm_RS07005	COG3064	Membrane
vm_RS07010	COG3059	membrane
vm_RS07015	COG0753	catalase activity
vm_RS07030	COG3097	Belongs to the UPF0267 family
vm_RS07060	COG0316	Belongs to the HesB IscA family
vm_RS07065	COG0719	Fe-S assembly protein
vm_RS07070	COG0396	ATPase activity
vm_RS07075	COG0719	Fe-S assembly protein
vm_RS07080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
vm_RS07085	COG2166	iron-sulfur cluster assembly
vm_RS07095	COG1780	Probably involved in ribonucleotide reductase function
vm_RS07100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
vm_RS07110	COG0577	efflux transmembrane transporter activity
vm_RS07110	COG1136	(ABC) transporter
vm_RS07115	COG1136	(ABC) transporter
vm_RS07115	COG0577	efflux transmembrane transporter activity
vm_RS07120	COG0577	efflux transmembrane transporter activity
vm_RS07150	COG2723	6-phospho-beta-galactosidase activity
vm_RS07155	COG1609	Transcriptional regulator
vm_RS07160	COG0251	oxidation-reduction process
vm_RS07165	COG2731	YhcH YjgK YiaL family protein
vm_RS07170	COG0584	glycerophosphoryl diester phosphodiesterase
vm_RS07180	COG3842	ATPase activity
vm_RS07185	COG0395	ABC-type sugar transport system, permease component
vm_RS07190	COG1175	transmembrane transport
vm_RS07210	COG0811	peptide transport
vm_RS07215	COG0811	peptide transport
vm_RS07220	COG0848	biopolymer transport protein
vm_RS07235	COG1793	dna ligase
vm_RS07245	COG0534	Mate efflux family protein
vm_RS07255	COG3001	Fructosamine kinase
vm_RS07265	COG0791	NLP P60 protein
vm_RS07270	COG0840	transmembrane signaling receptor activity
vm_RS07280	COG3148	PFAM DTW domain containing protein
vm_RS07285	COG1940	carbohydrate kinase activity
vm_RS07300	COG0746	molybdenum cofactor guanylyltransferase activity
vm_RS07305	COG3842	ATPase activity
vm_RS07310	COG4662	Binding-protein-dependent transport system inner membrane component
vm_RS07325	COG3852	Histidine kinase
vm_RS07330	COG0488	(ABC) transporter
vm_RS07340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
vm_RS07370	COG3383	formate dehydrogenase (NAD+) activity
vm_RS07370	COG0243	molybdopterin cofactor binding
vm_RS07375	COG0437	4 iron, 4 sulfur cluster binding
vm_RS07390	COG0004	ammonium transporteR
vm_RS07395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
vm_RS07400	COG1666	GTP binding
vm_RS07405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
vm_RS07420	COG2996	Protein conserved in bacteria
vm_RS07430	COG3008	intermembrane lipid transfer
vm_RS07435	COG2995	paraquat-inducible protein a
vm_RS07440	COG1132	(ABC) transporter
vm_RS07445	COG1956	GAF domain-containing protein
vm_RS07450	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
vm_RS07465	COG0308	aminopeptidase N
vm_RS07480	COG0167	dihydroorotate dehydrogenase activity
vm_RS07490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
vm_RS07490	COG0116	Belongs to the methyltransferase superfamily
vm_RS07500	COG0488	(ABC) transporter
vm_RS07515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
vm_RS07520	COG1067	ATP-dependent peptidase activity
vm_RS07525	COG3120	sequence-specific DNA binding
vm_RS07540	COG5002	protein histidine kinase activity
vm_RS07540	COG0784	Response regulator, receiver
vm_RS07555	COG3278	Belongs to the heme-copper respiratory oxidase family
vm_RS07570	COG2010	Cytochrome c
vm_RS07580	COG2217	Heavy metal translocating P-type atpase
vm_RS07595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
vm_RS07600	COG0589	response to stress
vm_RS07605	COG0037	tRNA processing
vm_RS07625	COG3842	ATPase activity
vm_RS07635	COG1177	transmembrane transport
vm_RS07665	COG2202	Pas domain
vm_RS07665	COG2205	protein histidine kinase activity
vm_RS07670	COG2199	diguanylate cyclase activity
vm_RS07685	COG1115	amino acid carrier protein
vm_RS07690	COG1280	lysine exporter protein (LysE YggA)
vm_RS07710	COG3501	Rhs element vgr protein
vm_RS07720	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
vm_RS07725	COG1960	acyl-CoA dehydrogenase activity
vm_RS07735	COG1012	belongs to the aldehyde dehydrogenase family
vm_RS07740	COG3384	dioxygenase
vm_RS07755	COG1012	belongs to the aldehyde dehydrogenase family
vm_RS07775	COG3971	2-oxopent-4-enoate hydratase activity
vm_RS07795	COG1846	Transcriptional regulator
vm_RS07835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
vm_RS07855	COG0513	Belongs to the DEAD box helicase family
vm_RS07865	COG0840	transmembrane signaling receptor activity
vm_RS07875	COG0477	Major facilitator Superfamily
vm_RS07880	COG0583	DNA-binding transcription factor activity
vm_RS07885	COG0443	Heat shock 70 kDa protein
vm_RS07890	COG0402	S-adenosylhomocysteine deaminase activity
vm_RS07905	COG3766	membrane
vm_RS07915	COG0754	glutathionylspermidine amidase activity
vm_RS07925	COG1643	Atp-dependent helicase
vm_RS07955	COG3300	MHYT domain
vm_RS07955	COG5001	Diguanylate cyclase
vm_RS07970	COG0443	Heat shock 70 kDa protein
vm_RS07975	COG3706	GGDEF domain
vm_RS08005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
vm_RS08010	COG0602	queuosine metabolic process
vm_RS08015	COG0561	phosphatase activity
vm_RS08025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vm_RS08030	COG4597	amino acid ABC transporter
vm_RS08035	COG0765	amino acid transport
vm_RS08040	COG1126	abc transporter atp-binding protein
vm_RS08045	COG0670	Belongs to the BI1 family
vm_RS08050	COG2920	part of a sulfur-relay system
vm_RS08055	COG1254	Belongs to the acylphosphatase family
vm_RS08065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
vm_RS08070	COG3706	GGDEF domain
vm_RS08085	COG3437	response regulator, receiver
vm_RS08090	COG0625	glutathione transferase activity
vm_RS08100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
vm_RS08110	COG2195	Cleaves the N-terminal amino acid of tripeptides
vm_RS08140	COG0372	Belongs to the citrate synthase family
vm_RS08145	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
vm_RS08155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
vm_RS08185	COG1129	ABC transporter
vm_RS08215	COG0745	RESPONSE REGULATOR receiver
vm_RS08220	COG5002	protein histidine kinase activity
vm_RS08225	COG3713	MltA-interacting MipA family protein
vm_RS08240	COG4191	Histidine kinase
vm_RS08240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
vm_RS08245	COG0471	metal ion transport
vm_RS08250	COG0840	transmembrane signaling receptor activity
vm_RS08255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
vm_RS08280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
vm_RS08290	COG3768	UPF0283 membrane protein
vm_RS08295	COG3106	COG3106 Predicted ATPase
vm_RS08310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
vm_RS08315	COG0494	nUDIX hydrolase
vm_RS08320	COG0814	amino acid
vm_RS08325	COG1760	l-serine dehydratase
vm_RS08330	COG0720	synthase
vm_RS08340	COG0017	Asparaginyl-tRNA synthetase
vm_RS08345	COG0351	phosphomethylpyrimidine kinase
vm_RS08350	COG0110	maltose O-acetyltransferase activity
vm_RS08355	COG2770	Histidine kinase
vm_RS08355	COG3437	response regulator, receiver
vm_RS08360	COG1448	Aminotransferase
vm_RS08375	COG0840	transmembrane signaling receptor activity
vm_RS08380	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
vm_RS08385	COG2943	transferase activity, transferring hexosyl groups
vm_RS08390	COG1609	Transcriptional regulator
vm_RS08395	COG3394	polysaccharide catabolic process
vm_RS08400	COG1486	melibiose metabolic process
vm_RS08405	COG1447	Phosphotransferase system cellobiose-specific component IIA
vm_RS08415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
vm_RS08420	COG0726	polysaccharide deacetylase
vm_RS08425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
vm_RS08430	COG1846	Transcriptional regulator
vm_RS08455	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
vm_RS08470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
vm_RS08475	COG3108	Peptidase M15
vm_RS08510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
vm_RS08520	COG2814	Major facilitator Superfamily
vm_RS08530	COG1054	Belongs to the UPF0176 family
vm_RS08535	COG1278	Cold shock
vm_RS08545	COG3088	subunit of a heme lyase
vm_RS08545	COG4235	cytochrome complex assembly
vm_RS08555	COG1138	Cytochrome C-type biogenesis protein
vm_RS08560	COG3301	Polysulphide reductase, NrfD
vm_RS08565	COG0437	4 iron, 4 sulfur cluster binding
vm_RS08570	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
vm_RS08575	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
vm_RS08590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
vm_RS08595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
vm_RS08630	COG0840	transmembrane signaling receptor activity
vm_RS08650	COG4139	cobalamin transport
vm_RS08655	COG2988	succinylglutamate desuccinylase activity
vm_RS08670	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
vm_RS08675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
vm_RS08680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
vm_RS08685	COG1823	symporter activity
vm_RS08690	COG2925	Exonuclease
vm_RS08695	COG1380	Effector of murein hydrolase LrgA
vm_RS08700	COG1346	cytolysis
vm_RS08720	COG0500	methyltransferase
vm_RS08735	COG0776	regulation of translation
vm_RS08740	COG0072	phenylalanine-tRNA ligase activity
vm_RS08740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vm_RS08745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
vm_RS08750	COG0456	acetyltransferase
vm_RS08785	COG0322	excinuclease ABC activity
vm_RS08790	COG2197	response regulator
vm_RS08795	COG0417	DNA replication proofreading
vm_RS08800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
vm_RS08810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
vm_RS08815	COG3099	Belongs to the UPF0263 family
vm_RS08830	COG1228	amidohydrolase
vm_RS08835	COG0010	Belongs to the arginase family
vm_RS08840	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
vm_RS08845	COG2986	histidine ammonia-lyase
vm_RS08865	COG0247	lactate metabolic process
vm_RS08865	COG0277	FAD linked oxidase domain protein
vm_RS08880	COG2885	chlorophyll binding
vm_RS08900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
vm_RS08910	COG0281	malic enzyme
vm_RS08920	COG2949	membrane
vm_RS08925	COG3706	GGDEF domain
vm_RS08940	COG0492	ferredoxin-NADP+ reductase activity
vm_RS08945	COG4988	ABC transporter
vm_RS08950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
vm_RS08955	COG1187	pseudouridine synthase activity
vm_RS08960	COG0009	L-threonylcarbamoyladenylate synthase
vm_RS08965	COG0613	PHP domain protein
vm_RS08975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
vm_RS08980	COG0512	Glutamine amidotransferase of anthranilate synthase
vm_RS08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
vm_RS08990	COG0134	indole-3-glycerol-phosphate synthase activity
vm_RS08990	COG0135	phosphoribosylanthranilate isomerase activity
vm_RS08995	COG0133	tryptophan synthase activity
vm_RS09000	COG0159	tryptophan synthase activity
vm_RS09015	COG1435	thymidine kinase activity
vm_RS09020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
vm_RS09025	COG1801	Protein of unknown function DUF72
vm_RS09030	COG4106	trans-aconitate 2-methyltransferase activity
vm_RS09035	COG0500	methyltransferase
vm_RS09040	COG4067	protein conserved in archaea
vm_RS09040	COG0189	ligase activity
vm_RS09055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
vm_RS09065	COG3852	Histidine kinase
vm_RS09085	COG3070	regulator of competence-specific genes
vm_RS09095	COG2431	L-lysine efflux transmembrane transporter activity
vm_RS09105	COG0076	glutamate decarboxylase activity
vm_RS09110	COG1737	Transcriptional regulator
vm_RS09115	COG1979	alcohol dehydrogenase
vm_RS09125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
vm_RS09130	COG2985	domain, Protein
vm_RS09130	COG3273	potassium ion transport
vm_RS09135	COG0542	response to heat
vm_RS09140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
vm_RS09145	COG1278	Cold shock
vm_RS09160	COG1187	pseudouridine synthase activity
vm_RS09165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
vm_RS09165	COG0140	phosphoribosyl-ATP diphosphatase activity
vm_RS09170	COG0107	imidazoleglycerol-phosphate synthase activity
vm_RS09175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
vm_RS09180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
vm_RS09185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
vm_RS09185	COG0131	Imidazoleglycerol-phosphate dehydratase
vm_RS09190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
vm_RS09195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
vm_RS09200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
vm_RS09205	COG1757	Na H antiporter
vm_RS09210	COG2916	Histone family protein nucleoid-structuring protein H-NS
vm_RS09215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
vm_RS09220	COG0482	sulfurtransferase activity
vm_RS09225	COG2915	High frequency lysogenization protein hflD homolog
vm_RS09230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
vm_RS09235	COG2268	Band 7 protein
vm_RS09245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
vm_RS09260	COG0300	oxidoreductase activity
vm_RS09270	COG0501	Belongs to the peptidase M48B family
vm_RS09280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
vm_RS09285	COG2226	methyltransferase
vm_RS09290	COG0156	8-amino-7-oxononanoate synthase activity
vm_RS09295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
vm_RS09300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
vm_RS09305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
vm_RS09310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
vm_RS09315	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
vm_RS09325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
vm_RS09330	COG3706	GGDEF domain
vm_RS09340	COG4120	Belongs to the binding-protein-dependent transport system permease family
vm_RS09350	COG4628	conserved protein (DUF2132)
vm_RS09355	COG3092	negative regulation of chromosome organization
vm_RS09360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
vm_RS09365	COG0280	phosphate acetyltransferase
vm_RS09365	COG0857	belongs to the CobB CobQ family
vm_RS09370	COG0435	Glutathione S-transferase
vm_RS09375	COG4608	Belongs to the ABC transporter superfamily
vm_RS09385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vm_RS09390	COG0601	transmembrane transport
vm_RS09410	COG2204	response regulator
vm_RS09415	COG3300	MHYT domain
vm_RS09415	COG5001	Diguanylate cyclase
vm_RS09420	COG4191	Histidine kinase
vm_RS09425	COG5002	protein histidine kinase activity
vm_RS09435	COG2201	protein-glutamate methylesterase activity
vm_RS09450	COG0009	L-threonylcarbamoyladenylate synthase
vm_RS09470	COG1881	PFAM PEBP family protein
vm_RS09495	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
vm_RS09500	COG3716	PTS system mannose fructose sorbose family IID component
vm_RS09510	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vm_RS09515	COG2222	sugar isomerase
vm_RS09525	COG1349	DNA-binding transcription factor activity
vm_RS09530	COG1349	DNA-binding transcription factor activity
vm_RS09545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
vm_RS09550	COG0640	Transcriptional regulator
vm_RS09555	COG0590	tRNA wobble adenosine to inosine editing
vm_RS09560	COG2076	Multidrug Resistance protein
vm_RS09565	COG2076	Multidrug Resistance protein
vm_RS09570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
vm_RS09590	COG1120	ATPase activity
vm_RS09595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
vm_RS09605	COG4264	IucA IucC family
vm_RS09630	COG2801	Transposase and inactivated derivatives
vm_RS09660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
vm_RS09665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
vm_RS09750	COG1396	sequence-specific DNA binding
vm_RS09775	COG3300	MHYT domain
vm_RS09775	COG5001	Diguanylate cyclase
vm_RS09795	COG1946	Acyl-CoA thioesterase
vm_RS09800	COG1522	sequence-specific DNA binding
vm_RS09810	COG0616	signal peptide processing
vm_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
vm_RS09820	COG2983	Belongs to the UPF0260 family
vm_RS09830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
vm_RS09835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
vm_RS09840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
vm_RS09845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
vm_RS09850	COG2832	Protein of unknown function (DUF454)
vm_RS09860	COG0745	RESPONSE REGULATOR receiver
vm_RS09865	COG0583	DNA-binding transcription factor activity
vm_RS09870	COG0778	Nitroreductase
vm_RS09875	COG1024	Enoyl-CoA hydratase
vm_RS09875	COG1250	3-hydroxyacyl-CoA dehydrogenase
vm_RS09880	COG0183	Belongs to the thiolase family
vm_RS09895	COG2067	long-chain fatty acid transport protein
vm_RS09900	COG2067	long-chain fatty acid transport protein
vm_RS09905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
vm_RS09910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
vm_RS09915	COG2982	Protein involved in outer membrane biogenesis
vm_RS09920	COG0572	uridine kinase
vm_RS09930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vm_RS09930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
vm_RS09940	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
vm_RS09950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
vm_RS09950	COG0617	tRNA 3'-terminal CCA addition
vm_RS09950	COG0517	IMP dehydrogenase activity
vm_RS09955	COG3706	GGDEF domain
vm_RS09960	COG0314	molybdopterin synthase activity
vm_RS09965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
vm_RS09970	COG0315	cyclic pyranopterin monophosphate synthase activity
vm_RS09975	COG0521	Mo-molybdopterin cofactor biosynthetic process
vm_RS09980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
vm_RS09985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
vm_RS09990	COG2198	Histidine kinase
vm_RS09995	COG2204	response regulator
vm_RS10000	COG0556	nucleotide-excision repair
vm_RS10015	COG3119	arylsulfatase activity
vm_RS10020	COG0641	radical SAM
vm_RS10025	COG0714	Associated with various cellular activities
vm_RS10060	COG4657	Part of a membrane complex involved in electron transport
vm_RS10065	COG2878	Part of a membrane complex involved in electron transport
vm_RS10070	COG4656	Part of a membrane complex involved in electron transport
vm_RS10075	COG4658	electron transport chain
vm_RS10085	COG4660	Part of a membrane complex involved in electron transport
vm_RS10090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
vm_RS10095	COG0346	lactoylglutathione lyase activity
vm_RS10115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
vm_RS10120	COG2056	Na+-H+ antiporter family
vm_RS10125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
vm_RS10130	COG1286	toxin biosynthetic process
vm_RS10135	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
vm_RS10140	COG0285	dihydrofolate synthase activity
vm_RS10145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
vm_RS10150	COG0101	tRNA pseudouridine synthase activity
vm_RS10165	COG1263	PTS System
vm_RS10165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vm_RS10165	COG2190	(PTS) system
vm_RS10170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
vm_RS10175	COG1846	Transcriptional regulator
vm_RS10175	COG1940	carbohydrate kinase activity
vm_RS10180	COG4651	solute:proton antiporter activity
vm_RS10180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
vm_RS10185	COG0367	asparagine synthase
vm_RS10190	COG0250	Participates in transcription elongation, termination and antitermination
vm_RS10195	COG3104	oligopeptide transport
vm_RS10200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
vm_RS10205	COG0563	adenylate kinase activity
vm_RS10210	COG0326	Molecular chaperone. Has ATPase activity
vm_RS10215	COG3710	Transcriptional regulator
vm_RS10230	COG0622	Phosphoesterase
vm_RS10235	COG1090	epimerase
vm_RS10240	COG0300	oxidoreductase activity
vm_RS10245	COG3118	belongs to the thioredoxin family
vm_RS10250	COG0330	HflC and HflK could
vm_RS10255	COG1585	Membrane protein implicated in regulation of membrane protease activity
vm_RS10260	COG0789	Transcriptional regulator
vm_RS10275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
vm_RS10280	COG3115	cell septum assembly
vm_RS10285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
vm_RS10290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
vm_RS10300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
vm_RS10310	COG2190	(PTS) system
vm_RS10315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
vm_RS10320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
vm_RS10325	COG1702	phosphate starvation-inducible protein PhoH
vm_RS10330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
vm_RS10335	COG4535	Mg2 and Co2 transporter CorC
vm_RS10340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
vm_RS10345	COG2888	peptidyl-tyrosine sulfation
vm_RS10350	COG0495	leucyl-tRNA aminoacylation
vm_RS10355	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
vm_RS10360	COG1466	dna polymerase III delta subunit
vm_RS10365	COG0799	negative regulation of ribosome biogenesis
vm_RS10370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
vm_RS10375	COG0768	penicillin binding
vm_RS10380	COG0772	Belongs to the SEDS family
vm_RS10385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
vm_RS10390	COG1686	Belongs to the peptidase S11 family
vm_RS10395	COG2921	Belongs to the UPF0250 family
vm_RS10400	COG0321	lipoyl(octanoyl) transferase activity
vm_RS10405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
vm_RS10415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
vm_RS10440	COG1596	polysaccharide export
vm_RS10450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
vm_RS10480	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
vm_RS10500	COG1045	serine acetyltransferase
vm_RS10525	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
vm_RS10530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
vm_RS10540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vm_RS10580	COG2205	protein histidine kinase activity
vm_RS10585	COG0745	RESPONSE REGULATOR receiver
vm_RS10590	COG0366	Alpha amylase catalytic
vm_RS10595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vm_RS10595	COG1263	PTS System
vm_RS10600	COG1609	Transcriptional regulator
vm_RS10605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
vm_RS10610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
vm_RS10615	COG2011	ABC-type metal ion transport system permease component
vm_RS10620	COG1464	Belongs to the NlpA lipoprotein family
vm_RS10625	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
vm_RS10635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
vm_RS10635	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
vm_RS10650	COG1611	Belongs to the LOG family
vm_RS10655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
vm_RS10660	COG2363	Small membrane protein
vm_RS10665	COG0583	DNA-binding transcription factor activity
vm_RS10675	COG0301	tRNA thio-modification
vm_RS10675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
vm_RS10685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
vm_RS10690	COG1722	exodeoxyribonuclease VII activity
vm_RS10695	COG0142	geranyltranstransferase activity
vm_RS10700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
vm_RS10705	COG0564	pseudouridine synthase activity
vm_RS10735	COG1671	Belongs to the UPF0178 family
vm_RS10740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
vm_RS10745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
vm_RS10750	COG0254	rRNA binding
vm_RS10755	COG1720	tRNA m6t6A37 methyltransferase activity
vm_RS10760	COG0442	prolyl-tRNA aminoacylation
vm_RS10780	COG0047	phosphoribosylformylglycinamidine synthase activity
vm_RS10780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
vm_RS10790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
vm_RS10805	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
vm_RS10840	COG0484	heat shock protein binding
vm_RS10845	COG0443	Heat shock 70 kDa protein
vm_RS10850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
vm_RS10855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
vm_RS10860	COG0497	DNA recombination
vm_RS10865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vm_RS10870	COG2914	Belongs to the UPF0125 (RnfH) family
vm_RS10875	COG2867	negative regulation of translational initiation
vm_RS10880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
vm_RS10890	COG0582	viral genome integration into host DNA
vm_RS10900	COG3423	Transcriptional regulator
vm_RS10905	COG2801	Transposase and inactivated derivatives
vm_RS10910	COG2842	Transposition protein
vm_RS11030	COG0640	Transcriptional regulator
vm_RS11040	COG4373	Mu-like prophage FluMu protein gp28
vm_RS11045	COG4383	Mu-like prophage protein gp29
vm_RS11075	COG4397	Mu-like prophage major head subunit gpT
vm_RS11085	COG4387	Mu-like prophage protein GP36
vm_RS11115	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
vm_RS11135	COG4384	Bacteriophage Mu Gp45 protein
vm_RS11145	COG3299	homolog of phage Mu protein gp47
vm_RS11150	COG3778	Protein conserved in bacteria
vm_RS11165	COG0582	viral genome integration into host DNA
vm_RS11170	COG2801	Transposase and inactivated derivatives
vm_RS11175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
vm_RS11180	COG0732	type I restriction modification DNA specificity domain
vm_RS11185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
vm_RS11200	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
vm_RS11205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
vm_RS11210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
vm_RS11230	COG3051	citrate lyase alpha subunit
vm_RS11235	COG2301	Belongs to the HpcH HpaI aldolase family
vm_RS11240	COG3052	prosthetic group binding
vm_RS11245	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
vm_RS11255	COG3630	sodium ion export across plasma membrane
vm_RS11260	COG0511	ligase activity, forming carbon-carbon bonds
vm_RS11260	COG5016	pyruvate
vm_RS11265	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
vm_RS11275	COG4565	transcriptional regulatory protein
vm_RS11285	COG2200	EAL domain
vm_RS11300	COG0583	DNA-binding transcription factor activity
vm_RS11310	COG1115	amino acid carrier protein
vm_RS11315	COG2015	COG2015, Alkyl sulfatase and related hydrolases
vm_RS11320	COG0583	DNA-binding transcription factor activity
vm_RS11325	COG1584	GPR1 FUN34 yaaH family protein
vm_RS11335	COG0519	Catalyzes the synthesis of GMP from XMP
vm_RS11335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
vm_RS11340	COG0517	IMP dehydrogenase activity
vm_RS11340	COG0516	GMP reductase activity
vm_RS11345	COG1570	exodeoxyribonuclease VII activity
vm_RS11360	COG1160	GTP binding
vm_RS11365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vm_RS11370	COG2976	Protein conserved in bacteria
vm_RS11375	COG0124	histidyl-tRNA synthetase
vm_RS11380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
vm_RS11385	COG1426	Protein conserved in bacteria
vm_RS11390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
vm_RS11395	COG0105	UTP biosynthetic process
vm_RS11400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
vm_RS11405	COG2975	iron-sulfur cluster assembly
vm_RS11410	COG0633	Ferredoxin
vm_RS11420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
vm_RS11430	COG0822	iron-sulfur transferase activity
vm_RS11440	COG1959	2 iron, 2 sulfur cluster binding
vm_RS11450	COG0483	inositol monophosphate 1-phosphatase activity
vm_RS11455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
vm_RS11460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
vm_RS11465	COG1862	Preprotein translocase
vm_RS11480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
vm_RS11485	COG0517	IMP dehydrogenase activity
vm_RS11490	COG0840	transmembrane signaling receptor activity
vm_RS11500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
vm_RS11505	COG0583	DNA-binding transcription factor activity
vm_RS11510	COG0450	alkyl hydroperoxide reductase
vm_RS11515	COG3142	Participates in the control of copper homeostasis
vm_RS11530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
vm_RS11535	COG0581	inorganic phosphate transmembrane transporter activity
vm_RS11545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
vm_RS11550	COG0248	Ppx GppA phosphatase
vm_RS11560	COG5002	protein histidine kinase activity
vm_RS11565	COG0745	RESPONSE REGULATOR receiver
vm_RS11575	COG0826	peptidase U32
vm_RS11580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
vm_RS11635	COG0542	response to heat
vm_RS11640	COG1496	oxidoreductase activity
vm_RS11645	COG0564	pseudouridine synthase activity
vm_RS11650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
vm_RS11655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
vm_RS11660	COG1605	Chorismate mutase
vm_RS11660	COG0077	Prephenate dehydratase
vm_RS11665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
vm_RS11670	COG5001	Diguanylate cyclase
vm_RS11680	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
vm_RS11690	COG0488	(ABC) transporter
vm_RS11700	COG1605	Chorismate mutase
vm_RS11700	COG0287	Prephenate dehydrogenase
vm_RS11705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
vm_RS11710	COG3275	phosphorelay sensor kinase activity
vm_RS11715	COG3279	Response regulator of the LytR AlgR family
vm_RS11725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
vm_RS11730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
vm_RS11745	COG1966	Carbon starvation protein
vm_RS11750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
vm_RS11755	COG1047	Peptidyl-prolyl cis-trans
vm_RS11760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
vm_RS11770	COG0196	riboflavin kinase activity
vm_RS11775	COG0728	peptidoglycan biosynthetic process
vm_RS11780	COG0268	Binds directly to 16S ribosomal RNA
vm_RS11785	COG0640	Transcriptional regulator
vm_RS11795	COG0583	DNA-binding transcription factor activity
vm_RS11800	COG1283	sodium-dependent phosphate transmembrane transporter activity
vm_RS11805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
vm_RS11810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
vm_RS11815	COG0730	response to heat
vm_RS11820	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
vm_RS11825	COG0494	nUDIX hydrolase
vm_RS11830	COG3066	DNA modification
vm_RS11835	COG0667	Aldo Keto reductase
vm_RS11850	COG2204	response regulator
vm_RS11855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
vm_RS11860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
vm_RS11875	COG0513	Belongs to the DEAD box helicase family
vm_RS11900	COG3153	acetyltransferase
vm_RS11905	COG3154	lipid carrier protein
vm_RS11915	COG0826	peptidase U32
vm_RS11920	COG0826	peptidase U32
vm_RS11930	COG1846	Transcriptional regulator
vm_RS11950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
vm_RS11960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
vm_RS11965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
vm_RS11970	COG0195	Participates in both transcription termination and antitermination
vm_RS11975	COG0779	Required for maturation of 30S ribosomal subunits
vm_RS11990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
vm_RS12005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
vm_RS12010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
vm_RS12015	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
vm_RS12020	COG1534	Rna-binding protein
vm_RS12025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
vm_RS12030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
vm_RS12035	COG2027	D-alanyl-D-alanine carboxypeptidase
vm_RS12040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
vm_RS12045	COG0739	heme binding
vm_RS12060	COG0316	Belongs to the HesB IscA family
vm_RS12070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
vm_RS12080	COG0628	permease
vm_RS12085	COG2813	Specifically methylates the guanine in position
vm_RS12095	COG0747	negative chemotaxis
vm_RS12105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vm_RS12110	COG0444	Belongs to the ABC transporter superfamily
vm_RS12115	COG4608	Belongs to the ABC transporter superfamily
vm_RS12125	COG2971	BadF BadG BcrA BcrD
vm_RS12140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
vm_RS12145	COG3842	ATPase activity
vm_RS12155	COG1840	ABC-type Fe3 transport system, periplasmic component
vm_RS12160	COG0004	ammonium transporteR
vm_RS12165	COG0347	Belongs to the P(II) protein family
vm_RS12170	COG3112	Uncharacterised protein family (UPF0231)
vm_RS12180	COG1752	Esterase of the alpha-beta hydrolase superfamily
vm_RS12185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
vm_RS12190	COG1643	Atp-dependent helicase
vm_RS12195	COG1489	DNA binding
vm_RS12205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
vm_RS12215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
vm_RS12220	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
vm_RS12225	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
vm_RS12230	COG0842	Transport permease protein
vm_RS12235	COG1131	(ABC) transporter
vm_RS12240	COG0659	secondary active sulfate transmembrane transporter activity
vm_RS12245	COG0288	reversible hydration of carbon dioxide
vm_RS12260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
vm_RS12265	COG3107	peptidoglycan biosynthetic process
vm_RS12270	COG0792	nuclease activity
vm_RS12275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
vm_RS12280	COG2823	Periplasmic or secreted lipoprotein
vm_RS12285	COG2969	positive regulation of protein catabolic process
vm_RS12290	COG0625	glutathione transferase activity
vm_RS12295	COG2857	Cytochrome c1
vm_RS12300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
vm_RS12305	COG0723	plastoquinol--plastocyanin reductase activity
vm_RS12310	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
vm_RS12315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
vm_RS12325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
vm_RS12335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
vm_RS12340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
vm_RS12345	COG0335	large ribosomal subunit rRNA binding
vm_RS12350	COG0336	Belongs to the RNA methyltransferase TrmD family
vm_RS12355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
vm_RS12360	COG0228	four-way junction DNA binding
vm_RS12365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
vm_RS12370	COG4137	Cytochrome C assembly protein
vm_RS12375	COG4536	flavin adenine dinucleotide binding
vm_RS12380	COG1854	S-ribosylhomocysteine lyase activity
vm_RS12385	COG2918	glutathione biosynthetic process
vm_RS12390	COG0612	Peptidase, M16
vm_RS12395	COG1238	metal cluster binding
vm_RS12405	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
vm_RS12410	COG5016	pyruvate
vm_RS12410	COG0511	ligase activity, forming carbon-carbon bonds
vm_RS12415	COG3630	sodium ion export across plasma membrane
vm_RS12460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
vm_RS12465	COG0527	aspartate kinase activity
vm_RS12470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
vm_RS12475	COG2137	regulation of response to DNA damage stimulus
vm_RS12480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
vm_RS12485	COG1546	Belongs to the CinA family
vm_RS12490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
vm_RS12495	COG4208	sulfate ABC transporter
vm_RS12515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
vm_RS12520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
vm_RS12530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
vm_RS12535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
vm_RS12540	COG0585	pseudouridine synthase activity
vm_RS12545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
vm_RS12550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
vm_RS12555	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
vm_RS12560	COG1968	undecaprenyl-diphosphatase activity
vm_RS12565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
vm_RS12570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
vm_RS12580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
vm_RS12585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
vm_RS12590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
vm_RS12595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
vm_RS12600	COG1610	YqeY-like protein
vm_RS12605	COG0358	DNA primase activity
vm_RS12620	COG0582	viral genome integration into host DNA
vm_RS12675	COG3339	Conserved Protein
vm_RS12690	COG2003	Belongs to the UPF0758 family
vm_RS12695	COG3547	Transposase (IS116 IS110 IS902 family)
vm_RS12765	COG1181	Belongs to the D-alanine--D-alanine ligase family
vm_RS12835	COG2207	Transcriptional regulator
vm_RS12910	COG2378	regulation of single-species biofilm formation
vm_RS12925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
vm_RS12930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
vm_RS12935	COG1349	DNA-binding transcription factor activity
vm_RS12955	COG1279	arginine transmembrane transporter activity
vm_RS12960	COG0668	transmembrane transport
vm_RS12965	COG0191	fructose-bisphosphate aldolase activity
vm_RS12970	COG0126	phosphoglycerate kinase activity
vm_RS12975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
vm_RS12980	COG4771	TonB-dependent receptor
vm_RS12985	COG0583	DNA-binding transcription factor activity
vm_RS12990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
vm_RS13000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
vm_RS13005	COG3091	SprT-like family
vm_RS13010	COG2356	endonuclease I
vm_RS13015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
vm_RS13020	COG0189	ligase activity
vm_RS13025	COG1678	Uncharacterized ACR, COG1678
vm_RS13030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
vm_RS13035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
vm_RS13055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
vm_RS13060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
vm_RS13065	COG0762	integral membrane protein
vm_RS13080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
vm_RS13085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
vm_RS13095	COG2066	Belongs to the glutaminase family
vm_RS13100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
vm_RS13105	COG1194	a g-specific adenine glycosylase
vm_RS13110	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
vm_RS13115	COG0741	lytic transglycosylase activity
vm_RS13140	COG0840	transmembrane signaling receptor activity
vm_RS13170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
vm_RS13175	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
vm_RS13180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
vm_RS13185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
vm_RS13190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
vm_RS13195	COG2967	ApaG domain
vm_RS13200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
vm_RS13210	COG3610	response to peptide
vm_RS13215	COG2966	Psort location CytoplasmicMembrane, score
vm_RS13220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
vm_RS13225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
vm_RS13230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
vm_RS13235	COG0142	geranyltranstransferase activity
vm_RS13240	COG0531	amino acid
vm_RS13245	COG0039	L-malate dehydrogenase activity
vm_RS13250	COG1438	arginine binding
vm_RS13255	COG2358	TRAP transporter, solute receptor (TAXI family
vm_RS13265	COG0589	response to stress
vm_RS13280	COG2706	6-phosphogluconolactonase activity
vm_RS13290	COG4145	pantothenate transmembrane transporter activity
vm_RS13300	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
vm_RS13310	COG1737	Transcriptional regulator
vm_RS13310	COG0837	glucose binding
vm_RS13325	COG3550	peptidyl-serine autophosphorylation
vm_RS13355	COG2801	Transposase and inactivated derivatives
vm_RS13385	COG2801	Transposase and inactivated derivatives
vm_RS13400	COG2235	arginine
vm_RS13405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
vm_RS13415	COG0312	modulator of DNA gyrase
vm_RS13420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
vm_RS13425	COG3164	Protein of unknown function
vm_RS13435	COG0424	maF-like protein
vm_RS13440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
vm_RS13445	COG1792	Involved in formation and maintenance of cell shape
vm_RS13450	COG1077	Cell shape determining protein MreB Mrl
vm_RS13485	COG2165	general secretion pathway protein
vm_RS13495	COG1459	type II secretion system
vm_RS13500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
vm_RS13510	COG3267	Type II secretory pathway component ExeA
vm_RS13510	COG3409	Peptidoglycan-binding domain 1 protein
vm_RS13535	COG2199	diguanylate cyclase activity
vm_RS13535	COG2200	EAL domain
vm_RS13555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
vm_RS13565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
vm_RS13570	COG0527	aspartate kinase activity
vm_RS13575	COG0646	methionine synthase
vm_RS13575	COG1410	methionine synthase
vm_RS13650	COG0175	sulfate reduction
vm_RS13655	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
vm_RS13660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
vm_RS13685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
vm_RS13690	COG0735	belongs to the Fur family
vm_RS13700	COG0166	Belongs to the GPI family
vm_RS13710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
vm_RS13725	COG0359	binds to the 23S rRNA
vm_RS13730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
vm_RS13735	COG2965	DNA replication, synthesis of RNA primer
vm_RS13740	COG0360	Binds together with S18 to 16S ribosomal RNA
vm_RS13750	COG2906	2 iron, 2 sulfur cluster binding
vm_RS13755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
vm_RS13760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
vm_RS13765	COG0049	tRNA binding
vm_RS13780	COG2923	Belongs to the DsrF TusC family
vm_RS13785	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
vm_RS13790	COG2964	Protein conserved in bacteria
vm_RS13795	COG0545	Peptidyl-prolyl cis-trans isomerase
vm_RS13805	COG2900	Belongs to the SlyX family
vm_RS13810	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
vm_RS13815	COG0330	HflC and HflK could
vm_RS13820	COG0330	HflC and HflK could
vm_RS13825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
vm_RS13830	COG1923	regulation of RNA biosynthetic process
vm_RS13835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
vm_RS13840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
vm_RS13845	COG0860	N-Acetylmuramoyl-L-alanine amidase
vm_RS13850	COG0802	atpase or kinase
vm_RS13855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
vm_RS13905	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
vm_RS13910	COG1162	GTPase activity
vm_RS13915	COG0688	phosphatidylethanolamine metabolic process
vm_RS13920	COG0471	metal ion transport
vm_RS13930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
vm_RS13935	COG4942	peptidase
vm_RS13950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
vm_RS13955	COG2816	NAD+ diphosphatase activity
vm_RS13960	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
vm_RS13965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
vm_RS13970	COG0085	RNA polymerase activity
vm_RS13975	COG0222	ribosome binding
vm_RS13980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
vm_RS13990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
vm_RS13995	COG0250	Participates in transcription elongation, termination and antitermination
vm_RS14000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
vm_RS14005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
vm_RS14030	COG1072	(Pantothenic acid kinase))
vm_RS14040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
vm_RS14055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
vm_RS14095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
vm_RS14110	COG3118	belongs to the thioredoxin family
vm_RS14115	COG0513	Belongs to the DEAD box helicase family
vm_RS14120	COG0248	Ppx GppA phosphatase
vm_RS14130	COG2814	Major facilitator Superfamily
vm_RS14150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
vm_RS14155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
vm_RS14160	COG0511	ligase activity, forming carbon-carbon bonds
vm_RS14165	COG0439	Biotin carboxylase
vm_RS14175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
vm_RS14180	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
vm_RS14185	COG1609	Transcriptional regulator
vm_RS14190	COG0129	dihydroxy-acid dehydratase activity
vm_RS14195	COG3265	gluconokinase activity
vm_RS14200	COG2610	gluconate transmembrane transporter activity
vm_RS14205	COG0800	Aldolase
vm_RS14220	COG0840	transmembrane signaling receptor activity
vm_RS14225	COG1982	Orn Lys Arg decarboxylase major
vm_RS14230	COG0531	amino acid
vm_RS14235	COG3710	Transcriptional regulator
vm_RS14240	COG0789	Transcriptional regulator
vm_RS14250	COG0151	Belongs to the GarS family
vm_RS14260	COG0776	regulation of translation
vm_RS14265	COG1253	flavin adenine dinucleotide binding
vm_RS14270	COG3068	Protein conserved in bacteria
vm_RS14280	COG1573	uracil-dna glycosylase
vm_RS14285	COG0668	transmembrane transport
vm_RS14290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
vm_RS14300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
vm_RS14310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
vm_RS14355	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
vm_RS14370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
vm_RS14405	COG1519	Transferase
vm_RS14430	COG3642	lipopolysaccharide core region biosynthetic process
vm_RS14435	COG0859	PFAM glycosyl transferase family 9
vm_RS14440	COG0463	Glycosyl transferase, family 2
vm_RS14445	COG0859	PFAM glycosyl transferase family 9
vm_RS14450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
vm_RS14455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
vm_RS14465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
vm_RS14470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
vm_RS14475	COG2003	Belongs to the UPF0758 family
vm_RS14480	COG0840	transmembrane signaling receptor activity
vm_RS14485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
vm_RS14490	COG1309	transcriptional regulator
vm_RS14495	COG1560	Kdo2-lipid A biosynthetic process
vm_RS14500	COG1560	Kdo2-lipid A biosynthetic process
vm_RS14505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
vm_RS14510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
vm_RS14515	COG1561	YicC-like family, N-terminal region
vm_RS14520	COG2862	Uncharacterized protein family, UPF0114
vm_RS14525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
vm_RS14525	COG1263	PTS System
vm_RS14530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
vm_RS14550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
vm_RS14555	COG1120	ATPase activity
vm_RS14560	COG4774	siderophore transport
vm_RS14575	COG0514	ATP-dependent DNA helicase (RecQ)
vm_RS14580	COG2962	Rard protein
vm_RS14585	COG0405	Gamma-glutamyltransferase
vm_RS14595	COG1280	lysine exporter protein (LysE YggA)
vm_RS14605	COG0210	DNA helicase
vm_RS14615	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
vm_RS14620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
vm_RS14630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
vm_RS14635	COG0601	transmembrane transport
vm_RS14640	COG0747	negative chemotaxis
vm_RS14690	COG1309	transcriptional regulator
vm_RS14695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
vm_RS14700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
vm_RS14705	COG2960	long-chain fatty acid transporting porin activity
vm_RS14710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
vm_RS14715	COG0583	DNA-binding transcription factor activity
vm_RS14790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
vm_RS14795	COG1739	Uncharacterized protein family UPF0029
vm_RS14800	COG1024	Enoyl-CoA hydratase
vm_RS14800	COG1250	3-hydroxyacyl-CoA dehydrogenase
vm_RS14805	COG0183	Belongs to the thiolase family
vm_RS14810	COG0583	DNA-binding transcription factor activity
vm_RS14815	COG2814	Major facilitator Superfamily
vm_RS14825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
vm_RS14830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
vm_RS14835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
vm_RS14840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
vm_RS14845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
vm_RS14850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
vm_RS14860	COG0356	it plays a direct role in the translocation of protons across the membrane
vm_RS14865	COG3312	ion transport
vm_RS14870	COG1475	DNA binding
vm_RS14875	COG1192	Involved in chromosome partitioning
vm_RS14880	COG0357	Ribosomal RNA small subunit methyltransferase G
vm_RS14885	COG0445	tRNA wobble uridine modification
vm_RS14890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
vm_RS14940	COG1074	ATP-dependent DNA helicase activity
vm_RS15035	COG4974	Belongs to the 'phage' integrase family
vm_RS15040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
vm_RS15045	COG0706	membrane insertase activity
vm_RS15055	COG0594	ribonuclease P activity
vm_RS15060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
vm_RS15065	COG1126	abc transporter atp-binding protein
vm_RS15090	COG0592	DNA-directed DNA polymerase activity
vm_RS15105	COG0187	DNA topoisomerase II activity
vm_RS15120	COG0187	DNA topoisomerase II activity
vm_RS15285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
vm_RS15475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
vm_RS15495	COG0352	thiamine-phosphate diphosphorylase activity
vm_RS15720	COG3072	Adenylate cyclase
vm_RS15725	COG3072	Adenylate cyclase
vm_RS15790	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
vm_RS16260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
vm_RS16570	COG0527	aspartate kinase activity
vm_RS16570	COG0460	homoserine dehydrogenase
vm_RS16650	COG0459	protein refolding
vm_RS16715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
vm_RS16930	COG0557	exoribonuclease II activity
vm_RS17160	COG1178	ABC-type Fe3 transport system permease component
vm_RS17280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
vm_RS17725	COG0737	Belongs to the 5'-nucleotidase family
vm_RS17790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
vm_RS17815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
vm_RS17990	COG2198	Histidine kinase
vm_RS17990	COG0784	Response regulator, receiver
vm_RS17990	COG5002	protein histidine kinase activity
vm_RS18120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
vm_RS18430	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
vm_RS18540	COG0587	DNA-directed DNA polymerase activity
vm_RS18630	COG0121	glutamine amidotransferase
vm_RS18650	COG1187	pseudouridine synthase activity
vm_RS18800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
vm_RS19170	COG0033	Phosphoglucomutase
vm_RS19305	COG2198	Histidine kinase
vm_RS19305	COG0784	Response regulator, receiver
vm_RS19305	COG0643	Histidine kinase
vm_RS19390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
vm_RS19555	COG0733	neurotransmitter:sodium symporter activity
vm_RS19645	COG1902	pentaerythritol trinitrate reductase activity
vm_RS19645	COG0446	pyridine nucleotide-disulphide oxidoreductase
vm_RS19855	COG0850	regulation of cytokinetic process
vm_RS20480	COG1199	ATP-dependent helicase activity