locus-tag	class	description
OFO16_RS00010	COG0592	DNA-directed DNA polymerase activity
OFO16_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OFO16_RS00020	COG0187	DNA topoisomerase II activity
OFO16_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
OFO16_RS00030	COG3977	Valine--pyruvate aminotransferase
OFO16_RS00035	COG0366	Alpha amylase catalytic
OFO16_RS00040	COG0751	glycine-tRNA ligase activity
OFO16_RS00050	COG2119	membrane
OFO16_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
OFO16_RS00075	COG0604	alcohol dehydrogenase
OFO16_RS00080	COG0183	Belongs to the thiolase family
OFO16_RS00085	COG1024	Enoyl-CoA hydratase
OFO16_RS00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
OFO16_RS00090	COG1739	Uncharacterized protein family UPF0029
OFO16_RS00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFO16_RS00135	COG1263	PTS System
OFO16_RS00135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_RS00140	COG2205	protein histidine kinase activity
OFO16_RS00150	COG0583	DNA-binding transcription factor activity
OFO16_RS00155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OFO16_RS00160	COG2960	long-chain fatty acid transporting porin activity
OFO16_RS00165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_RS00175	COG1309	transcriptional regulator
OFO16_RS00225	COG4166	transmembrane transport
OFO16_RS00230	COG0601	transmembrane transport
OFO16_RS00235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_RS00245	COG1609	Transcriptional regulator
OFO16_RS00250	COG0129	dihydroxy-acid dehydratase activity
OFO16_RS00255	COG3265	gluconokinase activity
OFO16_RS00260	COG2610	gluconate transmembrane transporter activity
OFO16_RS00265	COG0800	Aldolase
OFO16_RS00285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFO16_RS00290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OFO16_RS00300	COG1522	sequence-specific DNA binding
OFO16_RS00305	COG0742	ribosomal rna small subunit methyltransferase
OFO16_RS00320	COG0589	response to stress
OFO16_RS00325	COG1528	Iron-storage protein
OFO16_RS00335	COG2081	HI0933 family
OFO16_RS00350	COG1322	Protein conserved in bacteria
OFO16_RS00355	COG2226	methyltransferase
OFO16_RS00360	COG3165	ubiquinone biosynthetic process from chorismate
OFO16_RS00365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OFO16_RS00375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OFO16_RS00380	COG0805	protein transport
OFO16_RS00385	COG3263	regulation of cellular component size
OFO16_RS00390	COG0084	hydrolase, TatD family'
OFO16_RS00405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFO16_RS00405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFO16_RS00410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OFO16_RS00440	COG3385	transposase activity
OFO16_RS00445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OFO16_RS00450	COG2204	response regulator
OFO16_RS00455	COG3852	Histidine kinase
OFO16_RS00470	COG0174	glutamine synthetase
OFO16_RS00475	COG1217	gtp-binding protein TYPA
OFO16_RS00490	COG1295	ribonuclease BN
OFO16_RS00495	COG1490	D-aminoacyl-tRNA deacylase activity
OFO16_RS00500	COG0456	acetyltransferase
OFO16_RS00510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OFO16_RS00515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OFO16_RS00520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OFO16_RS00525	COG3031	protein transport across the cell outer membrane
OFO16_RS00535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFO16_RS00540	COG1459	type II secretion system
OFO16_RS00545	COG2165	general secretion pathway protein
OFO16_RS00550	COG2165	general secretion pathway protein
OFO16_RS00555	COG2165	general secretion pathway protein
OFO16_RS00560	COG4795	General secretion pathway protein
OFO16_RS00565	COG3156	type II secretion system protein K
OFO16_RS00570	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
OFO16_RS00575	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
OFO16_RS00585	COG1218	3'(2'),5'-bisphosphate nucleotidase
OFO16_RS00590	COG0494	nUDIX hydrolase
OFO16_RS00600	COG1040	competence protein
OFO16_RS00605	COG0596	Alpha beta hydrolase
OFO16_RS00615	COG2183	response to ionizing radiation
OFO16_RS00625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFO16_RS00645	COG2233	PERMEase
OFO16_RS00650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OFO16_RS00655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OFO16_RS00660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OFO16_RS00665	COG1758	RNA polymerase activity
OFO16_RS00670	COG0194	GDP metabolic process
OFO16_RS00685	COG0848	biopolymer transport protein
OFO16_RS00690	COG0811	peptide transport
OFO16_RS00710	COG4174	ABC transporter (Permease)
OFO16_RS00715	COG4239	(ABC) transporter, permease
OFO16_RS00720	COG0747	negative chemotaxis
OFO16_RS00725	COG0444	Belongs to the ABC transporter superfamily
OFO16_RS00730	COG4608	Belongs to the ABC transporter superfamily
OFO16_RS00745	COG3033	Beta-eliminating lyase
OFO16_RS00785	COG1561	YicC-like family, N-terminal region
OFO16_RS00790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OFO16_RS00795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OFO16_RS00800	COG1560	Kdo2-lipid A biosynthetic process
OFO16_RS00805	COG1309	transcriptional regulator
OFO16_RS00810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OFO16_RS00815	COG2003	Belongs to the UPF0758 family
OFO16_RS00835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OFO16_RS00840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OFO16_RS00845	COG0438	transferase activity, transferring glycosyl groups
OFO16_RS00850	COG0859	PFAM glycosyl transferase family 9
OFO16_RS00860	COG0438	transferase activity, transferring glycosyl groups
OFO16_RS00865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OFO16_RS00870	COG3642	lipopolysaccharide core region biosynthetic process
OFO16_RS00910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OFO16_RS00915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OFO16_RS00930	COG1519	Transferase
OFO16_RS00935	COG0859	PFAM glycosyl transferase family 9
OFO16_RS00940	COG1560	Kdo2-lipid A biosynthetic process
OFO16_RS00950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFO16_RS00995	COG0175	sulfate reduction
OFO16_RS01000	COG3273	potassium ion transport
OFO16_RS01000	COG0471	metal ion transport
OFO16_RS01005	COG0529	Catalyzes the synthesis of activated sulfate
OFO16_RS01010	COG2895	sulfate adenylyltransferase (ATP) activity
OFO16_RS01030	COG0438	transferase activity, transferring glycosyl groups
OFO16_RS01040	COG1216	Glycosyl transferase, family 2
OFO16_RS01050	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
OFO16_RS01055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OFO16_RS01075	COG1482	cell wall glycoprotein biosynthetic process
OFO16_RS01090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OFO16_RS01110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
OFO16_RS01120	COG0149	triose-phosphate isomerase activity
OFO16_RS01135	COG3152	Membrane
OFO16_RS01150	COG1494	fructose-1,6-bisphosphatase
OFO16_RS01160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OFO16_RS01165	COG1575	Belongs to the MenA family. Type 1 subfamily
OFO16_RS01170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OFO16_RS01185	COG1609	Transcriptional regulator
OFO16_RS01190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OFO16_RS01195	COG0254	rRNA binding
OFO16_RS01205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OFO16_RS01210	COG0088	Forms part of the polypeptide exit tunnel
OFO16_RS01220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OFO16_RS01225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OFO16_RS01230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OFO16_RS01235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OFO16_RS01245	COG0255	Belongs to the universal ribosomal protein uL29 family
OFO16_RS01250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OFO16_RS01260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OFO16_RS01265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OFO16_RS01280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OFO16_RS01295	COG1841	ribosomal large subunit assembly
OFO16_RS01300	COG0200	Binds to the 23S rRNA
OFO16_RS01305	COG0201	protein transport
OFO16_RS01310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OFO16_RS01315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OFO16_RS01320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OFO16_RS01330	COG0202	RNA polymerase activity
OFO16_RS01335	COG0203	ribosomal protein L17
OFO16_RS01345	COG0545	Peptidyl-prolyl cis-trans isomerase
OFO16_RS01355	COG2153	protein acetylation
OFO16_RS01360	COG0513	Belongs to the DEAD box helicase family
OFO16_RS01370	COG0737	Belongs to the 5'-nucleotidase family
OFO16_RS01375	COG1648	precorrin-2 dehydrogenase activity
OFO16_RS01375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OFO16_RS01380	COG0175	sulfate reduction
OFO16_RS01385	COG2895	sulfate adenylyltransferase (ATP) activity
OFO16_RS01390	COG0471	metal ion transport
OFO16_RS01390	COG3273	potassium ion transport
OFO16_RS01395	COG0529	Catalyzes the synthesis of activated sulfate
OFO16_RS01415	COG1136	(ABC) transporter
OFO16_RS01430	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
OFO16_RS01440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFO16_RS01450	COG2911	Protein conserved in bacteria
OFO16_RS01455	COG2105	PFAM AIG2 family protein
OFO16_RS01460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OFO16_RS01465	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
OFO16_RS01470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OFO16_RS01475	COG0163	prenyltransferase activity
OFO16_RS01485	COG1178	ABC-type Fe3 transport system permease component
OFO16_RS01490	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
OFO16_RS01515	COG0039	L-malate dehydrogenase activity
OFO16_RS01525	COG3385	transposase activity
OFO16_RS01530	COG0142	geranyltranstransferase activity
OFO16_RS01535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OFO16_RS01545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OFO16_RS01550	COG2966	Psort location CytoplasmicMembrane, score
OFO16_RS01570	COG2967	ApaG domain
OFO16_RS01575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OFO16_RS01580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OFO16_RS01585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFO16_RS01590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OFO16_RS01595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OFO16_RS01605	COG0066	3-isopropylmalate dehydratase activity
OFO16_RS01615	COG0473	3-isopropylmalate dehydrogenase activity
OFO16_RS01620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OFO16_RS01630	COG0671	phosphoesterase, PA-phosphatase related
OFO16_RS01640	COG0583	DNA-binding transcription factor activity
OFO16_RS01645	COG1022	Amp-dependent synthetase and ligase
OFO16_RS01650	COG0028	Belongs to the TPP enzyme family
OFO16_RS01655	COG0440	acetolactate synthase activity
OFO16_RS01660	COG3385	transposase activity
OFO16_RS01665	COG0469	pyruvate kinase activity
OFO16_RS01670	COG1349	DNA-binding transcription factor activity
OFO16_RS01675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OFO16_RS01685	COG2213	PTS system mannitol-specific
OFO16_RS01685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_RS01690	COG0246	Mannitol dehydrogenase
OFO16_RS01695	COG3722	fumarate hydratase activity
OFO16_RS01755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_RS01785	COG3293	Transposase
OFO16_RS01795	COG2378	regulation of single-species biofilm formation
OFO16_RS01825	COG3550	peptidyl-serine autophosphorylation
OFO16_RS01840	COG3339	Conserved Protein
OFO16_RS01920	COG0358	DNA primase activity
OFO16_RS01925	COG1610	YqeY-like protein
OFO16_RS01930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OFO16_RS01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OFO16_RS01940	COG3293	Transposase
OFO16_RS01945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OFO16_RS01950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OFO16_RS01955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OFO16_RS01960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OFO16_RS01965	COG1968	undecaprenyl-diphosphatase activity
OFO16_RS01970	COG0617	tRNA 3'-terminal CCA addition
OFO16_RS01975	COG3267	Type II secretory pathway component ExeA
OFO16_RS01975	COG3409	Peptidoglycan-binding domain 1 protein
OFO16_RS01985	COG4991	sh3 domain protein
OFO16_RS01990	COG0306	phosphate transporter
OFO16_RS01995	COG1392	Phosphate transport regulator
OFO16_RS02000	COG3025	triphosphatase activity
OFO16_RS02015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OFO16_RS02025	COG1538	Outer membrane efflux protein
OFO16_RS02030	COG0494	nUDIX hydrolase
OFO16_RS02035	COG3151	Protein conserved in bacteria
OFO16_RS02045	COG3150	esterase
OFO16_RS02055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OFO16_RS02060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OFO16_RS02070	COG3105	Protein conserved in bacteria
OFO16_RS02075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OFO16_RS02080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OFO16_RS02085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OFO16_RS02090	COG0723	plastoquinol--plastocyanin reductase activity
OFO16_RS02095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OFO16_RS02100	COG2857	Cytochrome c1
OFO16_RS02105	COG0625	glutathione transferase activity
OFO16_RS02110	COG2969	positive regulation of protein catabolic process
OFO16_RS02115	COG2823	Periplasmic or secreted lipoprotein
OFO16_RS02120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OFO16_RS02135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OFO16_RS02145	COG0275	rRNA processing
OFO16_RS02150	COG3116	cell division
OFO16_RS02155	COG0768	penicillin binding
OFO16_RS02160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OFO16_RS02165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OFO16_RS02170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OFO16_RS02175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OFO16_RS02180	COG0772	Belongs to the SEDS family
OFO16_RS02185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OFO16_RS02190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OFO16_RS02195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OFO16_RS02200	COG0849	cell division
OFO16_RS02205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OFO16_RS02210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
OFO16_RS02220	COG0653	protein targeting
OFO16_RS02225	COG0494	nUDIX hydrolase
OFO16_RS02235	COG0505	Belongs to the CarA family
OFO16_RS02240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OFO16_RS02245	COG0730	response to heat
OFO16_RS02250	COG0583	DNA-binding transcription factor activity
OFO16_RS02255	COG2860	membrane
OFO16_RS02260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OFO16_RS02270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OFO16_RS02280	COG0493	'glutamate synthase
OFO16_RS02285	COG0067	glutamate synthase
OFO16_RS02285	COG0070	glutamate synthase
OFO16_RS02285	COG0069	glutamate synthase activity
OFO16_RS02295	COG0067	glutamate synthase
OFO16_RS02295	COG0070	glutamate synthase
OFO16_RS02295	COG0069	glutamate synthase activity
OFO16_RS02300	COG1242	4 iron, 4 sulfur cluster binding
OFO16_RS02305	COG2198	Histidine kinase
OFO16_RS02305	COG5002	protein histidine kinase activity
OFO16_RS02305	COG0784	Response regulator, receiver
OFO16_RS02315	COG0745	RESPONSE REGULATOR receiver
OFO16_RS02325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OFO16_RS02340	COG0083	homoserine kinase activity
OFO16_RS02345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OFO16_RS02350	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
OFO16_RS02355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OFO16_RS02360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OFO16_RS02375	COG1115	amino acid carrier protein
OFO16_RS02380	COG3022	response to hydroperoxide
OFO16_RS02385	COG0513	Belongs to the DEAD box helicase family
OFO16_RS02390	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OFO16_RS02405	COG4974	Belongs to the 'phage' integrase family
OFO16_RS02410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFO16_RS02415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OFO16_RS02425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OFO16_RS02430	COG3829	transcription factor binding
OFO16_RS02430	COG3290	protein histidine kinase activity
OFO16_RS02440	COG0667	Aldo Keto reductase
OFO16_RS02450	COG3066	DNA modification
OFO16_RS02465	COG0730	response to heat
OFO16_RS02470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OFO16_RS02475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OFO16_RS02485	COG1283	sodium-dependent phosphate transmembrane transporter activity
OFO16_RS02490	COG0583	DNA-binding transcription factor activity
OFO16_RS02495	COG0640	Transcriptional regulator
OFO16_RS02500	COG0268	Binds directly to 16S ribosomal RNA
OFO16_RS02505	COG0728	peptidoglycan biosynthetic process
OFO16_RS02510	COG0196	riboflavin kinase activity
OFO16_RS02515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OFO16_RS02520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OFO16_RS02525	COG1047	Peptidyl-prolyl cis-trans
OFO16_RS02530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OFO16_RS02535	COG3279	Response regulator of the LytR AlgR family
OFO16_RS02540	COG3275	phosphorelay sensor kinase activity
OFO16_RS02545	COG1966	Carbon starvation protein
OFO16_RS02565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OFO16_RS02570	COG1472	Belongs to the glycosyl hydrolase 3 family
OFO16_RS02575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFO16_RS02580	COG0287	Prephenate dehydrogenase
OFO16_RS02580	COG1605	Chorismate mutase
OFO16_RS02585	COG0739	heme binding
OFO16_RS02590	COG0488	(ABC) transporter
OFO16_RS02600	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
OFO16_RS02605	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
OFO16_RS02610	COG0077	Prephenate dehydratase
OFO16_RS02610	COG1605	Chorismate mutase
OFO16_RS02615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OFO16_RS02620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OFO16_RS02625	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFO16_RS02630	COG0564	pseudouridine synthase activity
OFO16_RS02640	COG0542	response to heat
OFO16_RS02655	COG1116	anion transmembrane transporter activity
OFO16_RS02710	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
OFO16_RS02720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OFO16_RS02725	COG0826	peptidase U32
OFO16_RS02730	COG2974	May be involved in recombination
OFO16_RS02735	COG0745	RESPONSE REGULATOR receiver
OFO16_RS02740	COG5002	protein histidine kinase activity
OFO16_RS02750	COG0248	Ppx GppA phosphatase
OFO16_RS02755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OFO16_RS02765	COG0581	inorganic phosphate transmembrane transporter activity
OFO16_RS02770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OFO16_RS02775	COG0704	Plays a role in the regulation of phosphate uptake
OFO16_RS02785	COG3142	Participates in the control of copper homeostasis
OFO16_RS02790	COG0450	alkyl hydroperoxide reductase
OFO16_RS02795	COG0583	DNA-binding transcription factor activity
OFO16_RS02800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OFO16_RS02810	COG0517	IMP dehydrogenase activity
OFO16_RS02820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OFO16_RS02825	COG0343	queuine tRNA-ribosyltransferase activity
OFO16_RS02830	COG1862	Preprotein translocase
OFO16_RS02835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFO16_RS02840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFO16_RS02845	COG0483	inositol monophosphate 1-phosphatase activity
OFO16_RS02850	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
OFO16_RS02860	COG1104	cysteine desulfurase activity
OFO16_RS02865	COG0822	iron-sulfur transferase activity
OFO16_RS02870	COG0316	Belongs to the HesB IscA family
OFO16_RS02880	COG0443	Heat shock 70 kDa protein
OFO16_RS02885	COG0633	Ferredoxin
OFO16_RS02890	COG2975	iron-sulfur cluster assembly
OFO16_RS02895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OFO16_RS02900	COG0105	UTP biosynthetic process
OFO16_RS02915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OFO16_RS02920	COG0124	histidyl-tRNA synthetase
OFO16_RS02925	COG2976	Protein conserved in bacteria
OFO16_RS02930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFO16_RS02935	COG1160	GTP binding
OFO16_RS02940	COG3293	Transposase
OFO16_RS02960	COG0516	GMP reductase activity
OFO16_RS02960	COG0517	IMP dehydrogenase activity
OFO16_RS02965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OFO16_RS02965	COG0519	Catalyzes the synthesis of GMP from XMP
OFO16_RS02970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OFO16_RS02975	COG0235	Class ii aldolase
OFO16_RS02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OFO16_RS02990	COG0235	Class ii aldolase
OFO16_RS02995	COG1620	l-lactate permease
OFO16_RS03000	COG1620	l-lactate permease
OFO16_RS03020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFO16_RS03025	COG2169	Transcriptional regulator
OFO16_RS03025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OFO16_RS03035	COG3093	addiction module antidote protein HigA
OFO16_RS03045	COG1757	Na H antiporter
OFO16_RS03050	COG1584	GPR1 FUN34 yaaH family protein
OFO16_RS03065	COG1473	amidohydrolase
OFO16_RS03075	COG1115	amino acid carrier protein
OFO16_RS03080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_RS03090	COG2873	o-acetylhomoserine
OFO16_RS03095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFO16_RS03115	COG3153	acetyltransferase
OFO16_RS03115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OFO16_RS03120	COG0583	DNA-binding transcription factor activity
OFO16_RS03125	COG0235	Class ii aldolase
OFO16_RS03130	COG4806	L-rhamnose isomerase
OFO16_RS03135	COG1070	Carbohydrate kinase
OFO16_RS03140	COG3254	rhamnose metabolic process
OFO16_RS03225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OFO16_RS03230	COG2867	negative regulation of translational initiation
OFO16_RS03235	COG2914	Belongs to the UPF0125 (RnfH) family
OFO16_RS03240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFO16_RS03245	COG0497	DNA recombination
OFO16_RS03250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OFO16_RS03255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OFO16_RS03260	COG1301	dicarboxylic acid transport
OFO16_RS03270	COG0484	heat shock protein binding
OFO16_RS03300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OFO16_RS03315	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OFO16_RS03320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OFO16_RS03320	COG0047	phosphoribosylformylglycinamidine synthase activity
OFO16_RS03350	COG3385	transposase activity
OFO16_RS03355	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFO16_RS03360	COG2252	PERMEase
OFO16_RS03365	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
OFO16_RS03370	COG1073	alpha beta
OFO16_RS03380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OFO16_RS03385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OFO16_RS03390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OFO16_RS03395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OFO16_RS03395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OFO16_RS03410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OFO16_RS03420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OFO16_RS03425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OFO16_RS03430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OFO16_RS03435	COG0142	geranyltranstransferase activity
OFO16_RS03445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OFO16_RS03450	COG2885	chlorophyll binding
OFO16_RS03455	COG0301	tRNA thio-modification
OFO16_RS03455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFO16_RS03460	COG0583	DNA-binding transcription factor activity
OFO16_RS03470	COG2363	Small membrane protein
OFO16_RS03475	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
OFO16_RS03480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFO16_RS03485	COG1611	Belongs to the LOG family
OFO16_RS03510	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
OFO16_RS03515	COG1464	Belongs to the NlpA lipoprotein family
OFO16_RS03520	COG2011	ABC-type metal ion transport system permease component
OFO16_RS03525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OFO16_RS03530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OFO16_RS03540	COG1263	PTS System
OFO16_RS03540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_RS03545	COG0366	Alpha amylase catalytic
OFO16_RS03555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OFO16_RS03560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OFO16_RS03575	COG1686	Belongs to the peptidase S11 family
OFO16_RS03580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OFO16_RS03585	COG0772	Belongs to the SEDS family
OFO16_RS03590	COG0768	penicillin binding
OFO16_RS03600	COG0799	negative regulation of ribosome biogenesis
OFO16_RS03605	COG1466	dna polymerase III delta subunit
OFO16_RS03610	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
OFO16_RS03615	COG0495	leucyl-tRNA aminoacylation
OFO16_RS03620	COG2888	peptidyl-tyrosine sulfation
OFO16_RS03625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
OFO16_RS03630	COG4535	Mg2 and Co2 transporter CorC
OFO16_RS03640	COG1702	phosphate starvation-inducible protein PhoH
OFO16_RS03645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OFO16_RS03650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFO16_RS03760	COG0012	GTP binding
OFO16_RS03770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OFO16_RS03775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OFO16_RS03780	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OFO16_RS03785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OFO16_RS03795	COG2890	protein-(glutamine-N5) methyltransferase activity
OFO16_RS03800	COG3094	Invasion gene expression up-regulator, SirB
OFO16_RS03805	COG2912	Transglutaminase-like superfamily
OFO16_RS03810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OFO16_RS03815	COG0737	Belongs to the 5'-nucleotidase family
OFO16_RS03820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OFO16_RS03825	COG3385	transposase activity
OFO16_RS03830	COG1187	pseudouridine synthase activity
OFO16_RS03835	COG2840	Smr protein MutS2
OFO16_RS03865	COG2217	Heavy metal translocating P-type atpase
OFO16_RS03865	COG2608	mercury ion transmembrane transporter activity
OFO16_RS03920	COG0835	chemotaxis
OFO16_RS03920	COG0784	Response regulator, receiver
OFO16_RS03925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OFO16_RS03930	COG1815	bacterial-type flagellum-dependent cell motility
OFO16_RS03945	COG1749	Flagellar hook protein flgE
OFO16_RS03950	COG4787	bacterial-type flagellum-dependent cell motility
OFO16_RS03960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
OFO16_RS03965	COG1706	bacterial-type flagellum-dependent cell motility
OFO16_RS03970	COG1705	Flagellar rod assembly protein muramidase FlgJ
OFO16_RS03970	COG3951	Flagellar rod assembly protein muramidase FlgJ
OFO16_RS03980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_RS03985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_RS03990	COG2190	(PTS) system
OFO16_RS03995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OFO16_RS04000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_RS04005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OFO16_RS04010	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
OFO16_RS04015	COG3115	cell septum assembly
OFO16_RS04020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OFO16_RS04050	COG0330	HflC and HflK could
OFO16_RS04055	COG3118	belongs to the thioredoxin family
OFO16_RS04060	COG0300	oxidoreductase activity
OFO16_RS04065	COG1090	epimerase
OFO16_RS04095	COG0622	Phosphoesterase
OFO16_RS04115	COG3710	Transcriptional regulator
OFO16_RS04120	COG0326	Molecular chaperone. Has ATPase activity
OFO16_RS04130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OFO16_RS04140	COG3104	oligopeptide transport
OFO16_RS04150	COG0367	asparagine synthase
OFO16_RS04155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OFO16_RS04155	COG4651	solute:proton antiporter activity
OFO16_RS04160	COG1846	Transcriptional regulator
OFO16_RS04160	COG1940	carbohydrate kinase activity
OFO16_RS04165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OFO16_RS04170	COG1263	PTS System
OFO16_RS04170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_RS04170	COG2190	(PTS) system
OFO16_RS04175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OFO16_RS04180	COG0735	belongs to the Fur family
OFO16_RS04190	COG0716	FMN binding
OFO16_RS04200	COG0596	Alpha beta hydrolase
OFO16_RS04205	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
OFO16_RS04210	COG0033	Phosphoglucomutase
OFO16_RS04220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OFO16_RS04235	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OFO16_RS04240	COG1053	succinate dehydrogenase
OFO16_RS04250	COG0567	Dehydrogenase, E1 component
OFO16_RS04255	COG0508	dehydrogenase complex catalyzes the overall conversion of
OFO16_RS04260	COG0045	succinate-CoA ligase (ADP-forming) activity
OFO16_RS04270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OFO16_RS04275	COG1121	(ABC) transporter
OFO16_RS04280	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
OFO16_RS04285	COG4977	sequence-specific DNA binding
OFO16_RS04290	COG1918	ferrous iron import across plasma membrane
OFO16_RS04310	COG0018	arginyl-trna synthetase
OFO16_RS04315	COG3102	Protein conserved in bacteria
OFO16_RS04330	COG3385	transposase activity
OFO16_RS04335	COG0788	formyltetrahydrofolate deformylase activity
OFO16_RS04340	COG1199	ATP-dependent helicase activity
OFO16_RS04345	COG1214	PFAM Peptidase M22, glycoprotease
OFO16_RS04360	COG2267	carboxylic ester hydrolase activity
OFO16_RS04365	COG0318	PFAM AMP-dependent synthetase and ligase
OFO16_RS04370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
OFO16_RS04375	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
OFO16_RS04380	COG2894	cell division
OFO16_RS04390	COG3100	YcgL domain-containing protein
OFO16_RS04395	COG2951	lytic endotransglycosylase activity
OFO16_RS04400	COG0583	DNA-binding transcription factor activity
OFO16_RS04405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFO16_RS04410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OFO16_RS04425	COG0583	DNA-binding transcription factor activity
OFO16_RS04430	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OFO16_RS04435	COG1301	dicarboxylic acid transport
OFO16_RS04440	COG2855	membrane
OFO16_RS04460	COG0402	S-adenosylhomocysteine deaminase activity
OFO16_RS04545	COG0732	type I restriction modification DNA specificity domain
OFO16_RS04615	COG1396	sequence-specific DNA binding
OFO16_RS04620	COG3550	peptidyl-serine autophosphorylation
OFO16_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS04640	COG1169	isochorismate synthase
OFO16_RS04645	COG1021	2,3-dihydroxybenzoate-AMP ligase
OFO16_RS04650	COG1535	isochorismatase
OFO16_RS04650	COG3433	isochorismatase activity
OFO16_RS04655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OFO16_RS04655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OFO16_RS04670	COG4771	TonB-dependent receptor
OFO16_RS04675	COG1253	flavin adenine dinucleotide binding
OFO16_RS04680	COG0513	Belongs to the DEAD box helicase family
OFO16_RS04685	COG0569	domain protein
OFO16_RS04690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFO16_RS04695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OFO16_RS04715	COG1175	transmembrane transport
OFO16_RS04725	COG3842	ATPase activity
OFO16_RS04730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFO16_RS04735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OFO16_RS04740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OFO16_RS04760	COG3293	Transposase
OFO16_RS04775	COG0544	peptidyl-prolyl cis-trans isomerase activity
OFO16_RS04785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OFO16_RS04790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OFO16_RS04795	COG0776	regulation of translation
OFO16_RS04800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFO16_RS04805	COG1555	photosystem II stabilization
OFO16_RS04820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
OFO16_RS04825	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
OFO16_RS04830	COG0436	Aminotransferase
OFO16_RS04835	COG1169	isochorismate synthase
OFO16_RS04840	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OFO16_RS04845	COG0596	Alpha beta hydrolase
OFO16_RS04850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OFO16_RS04870	COG2855	membrane
OFO16_RS04875	COG0477	Major facilitator Superfamily
OFO16_RS04915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_RS04920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_RS04935	COG1522	sequence-specific DNA binding
OFO16_RS04940	COG1946	Acyl-CoA thioesterase
OFO16_RS04945	COG3126	Type III secretion system lipoprotein chaperone (YscW)
OFO16_RS04965	COG0583	DNA-binding transcription factor activity
OFO16_RS04980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OFO16_RS04985	COG3842	ATPase activity
OFO16_RS05000	COG0439	Biotin carboxylase
OFO16_RS05010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_RS05015	COG0174	glutamine synthetase
OFO16_RS05020	COG0174	glutamine synthetase
OFO16_RS05030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFO16_RS05035	COG3842	ATPase activity
OFO16_RS05040	COG1176	ABC-type spermidine putrescine transport system, permease component I
OFO16_RS05045	COG1177	transmembrane transport
OFO16_RS05055	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS05060	COG0519	Catalyzes the synthesis of GMP from XMP
OFO16_RS05065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OFO16_RS05070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OFO16_RS05075	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
OFO16_RS05080	COG0516	GMP reductase activity
OFO16_RS05080	COG0517	IMP dehydrogenase activity
OFO16_RS05085	COG2217	Heavy metal translocating P-type atpase
OFO16_RS05105	COG0537	adenosine 5'-monophosphoramidase activity
OFO16_RS05130	COG3150	esterase
OFO16_RS05135	COG1252	NADH dehydrogenase
OFO16_RS05150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OFO16_RS05160	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFO16_RS05165	COG1136	(ABC) transporter
OFO16_RS05170	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFO16_RS05180	COG2333	competence protein COMEC
OFO16_RS05180	COG0658	competence protein
OFO16_RS05185	COG1132	(ABC) transporter
OFO16_RS05200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OFO16_RS05205	COG2719	SpoVR family
OFO16_RS05210	COG2718	Belongs to the UPF0229 family
OFO16_RS05215	COG2766	serine protein kinase
OFO16_RS05220	COG3013	Belongs to the UPF0304 family
OFO16_RS05230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OFO16_RS05240	COG1882	Formate acetyltransferase
OFO16_RS05275	COG0708	Exodeoxyribonuclease III
OFO16_RS05285	COG3923	Primosomal replication protein n
OFO16_RS05290	COG0730	response to heat
OFO16_RS05295	COG1199	ATP-dependent helicase activity
OFO16_RS05305	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OFO16_RS05310	COG1187	pseudouridine synthase activity
OFO16_RS05320	COG1278	Cold shock
OFO16_RS05325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OFO16_RS05330	COG0542	response to heat
OFO16_RS05335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OFO16_RS05340	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
OFO16_RS05345	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OFO16_RS05355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OFO16_RS05365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OFO16_RS05370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OFO16_RS05375	COG0297	glycogen (starch) synthase activity
OFO16_RS05395	COG3070	regulator of competence-specific genes
OFO16_RS05400	COG1609	Transcriptional regulator
OFO16_RS05405	COG3381	protein complex oligomerization
OFO16_RS05410	COG0745	RESPONSE REGULATOR receiver
OFO16_RS05415	COG1434	Gram-negative-bacterium-type cell wall biogenesis
OFO16_RS05420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OFO16_RS05425	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
OFO16_RS05430	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
OFO16_RS05435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
OFO16_RS05470	COG4067	protein conserved in archaea
OFO16_RS05470	COG0189	ligase activity
OFO16_RS05475	COG0500	methyltransferase
OFO16_RS05480	COG4106	trans-aconitate 2-methyltransferase activity
OFO16_RS05485	COG1801	Protein of unknown function DUF72
OFO16_RS05495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OFO16_RS05500	COG0632	four-way junction helicase activity
OFO16_RS05505	COG2255	four-way junction helicase activity
OFO16_RS05510	COG1271	oxidase subunit
OFO16_RS05515	COG1294	oxidase, subunit
OFO16_RS05520	COG4890	Cyd operon protein YbgT
OFO16_RS05530	COG0824	Thioesterase
OFO16_RS05535	COG0811	peptide transport
OFO16_RS05550	COG0823	Involved in the tonB-independent uptake of proteins
OFO16_RS05555	COG2885	chlorophyll binding
OFO16_RS05560	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
OFO16_RS05575	COG3766	membrane
OFO16_RS05585	COG0754	glutathionylspermidine amidase activity
OFO16_RS05600	COG1858	cytochrome C peroxidase
OFO16_RS05620	COG2205	protein histidine kinase activity
OFO16_RS05620	COG0784	Response regulator, receiver
OFO16_RS05645	COG2194	sulfuric ester hydrolase activity
OFO16_RS05675	COG1215	transferase activity, transferring glycosyl groups
OFO16_RS05680	COG1215	transferase activity, transferring glycosyl groups
OFO16_RS05685	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
OFO16_RS05765	COG3052	prosthetic group binding
OFO16_RS05780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OFO16_RS05785	COG1396	sequence-specific DNA binding
OFO16_RS05790	COG3135	benzoate transporter
OFO16_RS05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_RS05800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_RS05835	COG0686	Belongs to the AlaDH PNT family
OFO16_RS05845	COG1674	ftsk spoiiie
OFO16_RS05850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OFO16_RS05855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OFO16_RS05865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFO16_RS05875	COG0156	8-amino-7-oxononanoate synthase activity
OFO16_RS05885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OFO16_RS05895	COG0501	Belongs to the peptidase M48B family
OFO16_RS05905	COG4221	oxidoreductase activity
OFO16_RS05920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OFO16_RS05940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OFO16_RS05950	COG0482	sulfurtransferase activity
OFO16_RS05960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_RS05970	COG1757	Na H antiporter
OFO16_RS05985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OFO16_RS05990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OFO16_RS05995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OFO16_RS06000	COG0131	Imidazoleglycerol-phosphate dehydratase
OFO16_RS06000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OFO16_RS06005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OFO16_RS06010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OFO16_RS06020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OFO16_RS06020	COG0140	phosphoribosyl-ATP diphosphatase activity
OFO16_RS06025	COG3012	SEC-C Motif Domain Protein
OFO16_RS06030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
OFO16_RS06035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFO16_RS06040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OFO16_RS06045	COG0215	cysteine-tRNA ligase activity
OFO16_RS06050	COG1435	thymidine kinase activity
OFO16_RS06055	COG3385	transposase activity
OFO16_RS06060	COG1434	Gram-negative-bacterium-type cell wall biogenesis
OFO16_RS06075	COG2116	formate transmembrane transporter activity
OFO16_RS06085	COG0390	transport system, permease component
OFO16_RS06090	COG4459	periplasmic nitrate reductase
OFO16_RS06095	COG3005	denitrification pathway
OFO16_RS06100	COG0243	molybdopterin cofactor binding
OFO16_RS06115	COG1227	inorganic diphosphatase activity
OFO16_RS06125	COG4172	Belongs to the ABC transporter superfamily
OFO16_RS06150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OFO16_RS06155	COG1842	Phage shock protein A
OFO16_RS06165	COG1983	PspC domain protein
OFO16_RS06185	COG2818	Glycosylase
OFO16_RS06190	COG0626	cystathionine gamma-synthase activity
OFO16_RS06200	COG0733	neurotransmitter:sodium symporter activity
OFO16_RS06205	COG0564	pseudouridine synthase activity
OFO16_RS06210	COG0116	Belongs to the methyltransferase superfamily
OFO16_RS06210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OFO16_RS06215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFO16_RS06220	COG1151	hydroxylamine reductase activity
OFO16_RS06225	COG3604	Transcriptional regulator
OFO16_RS06235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OFO16_RS06240	COG4136	ATPase activity
OFO16_RS06245	COG4135	transport system, permease component
OFO16_RS06250	COG4134	Bacterial extracellular solute-binding protein
OFO16_RS06260	COG3313	Fe-S protein
OFO16_RS06275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OFO16_RS06280	COG0642	Histidine kinase
OFO16_RS06295	COG1061	Type III restriction enzyme res subunit
OFO16_RS06300	COG1187	pseudouridine synthase activity
OFO16_RS06305	COG2814	Major facilitator Superfamily
OFO16_RS06335	COG3005	denitrification pathway
OFO16_RS06340	COG0702	epimerase
OFO16_RS06345	COG0534	Mate efflux family protein
OFO16_RS06350	COG1136	(ABC) transporter
OFO16_RS06365	COG3385	transposase activity
OFO16_RS06370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OFO16_RS06380	COG1960	acyl-CoA dehydrogenase activity
OFO16_RS06385	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OFO16_RS06390	COG2985	domain, Protein
OFO16_RS06390	COG3273	potassium ion transport
OFO16_RS06395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OFO16_RS06400	COG1454	alcohol dehydrogenase
OFO16_RS06400	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS06405	COG3385	transposase activity
OFO16_RS06410	COG1737	Transcriptional regulator
OFO16_RS06415	COG0076	glutamate decarboxylase activity
OFO16_RS06425	COG2431	L-lysine efflux transmembrane transporter activity
OFO16_RS06435	COG3070	regulator of competence-specific genes
OFO16_RS06450	COG4191	Histidine kinase
OFO16_RS06450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS06460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
OFO16_RS06470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OFO16_RS06475	COG4988	ABC transporter
OFO16_RS06480	COG0492	ferredoxin-NADP+ reductase activity
OFO16_RS06500	COG0471	metal ion transport
OFO16_RS06505	COG2949	membrane
OFO16_RS06510	COG0281	malic enzyme
OFO16_RS06515	COG1643	Atp-dependent helicase
OFO16_RS06530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OFO16_RS06565	COG0247	lactate metabolic process
OFO16_RS06565	COG0277	FAD linked oxidase domain protein
OFO16_RS06570	COG2020	methyltransferase activity
OFO16_RS06575	COG0583	DNA-binding transcription factor activity
OFO16_RS06580	COG3384	dioxygenase
OFO16_RS06585	COG0435	Glutathione S-transferase
OFO16_RS06595	COG0010	Belongs to the arginase family
OFO16_RS06600	COG1228	amidohydrolase
OFO16_RS06620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OFO16_RS06630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OFO16_RS06645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OFO16_RS06650	COG0072	phenylalanine-tRNA ligase activity
OFO16_RS06650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFO16_RS06655	COG1621	beta-fructofuranosidase activity
OFO16_RS06660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_RS06675	COG0776	regulation of translation
OFO16_RS06685	COG0500	methyltransferase
OFO16_RS06690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
OFO16_RS06695	COG0295	cytidine deaminase activity
OFO16_RS06700	COG1346	cytolysis
OFO16_RS06705	COG1380	Effector of murein hydrolase LrgA
OFO16_RS06710	COG2925	Exonuclease
OFO16_RS06735	COG1823	symporter activity
OFO16_RS06740	COG0702	epimerase
OFO16_RS06745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OFO16_RS06755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
OFO16_RS06775	COG2988	succinylglutamate desuccinylase activity
OFO16_RS06780	COG4139	cobalamin transport
OFO16_RS06805	COG0583	DNA-binding transcription factor activity
OFO16_RS06815	COG1451	nucleotide metabolic process
OFO16_RS06820	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
OFO16_RS06850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OFO16_RS06855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFO16_RS06870	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFO16_RS06880	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
OFO16_RS06890	COG0625	glutathione transferase activity
OFO16_RS06915	COG4145	pantothenate transmembrane transporter activity
OFO16_RS06930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OFO16_RS06950	COG0579	oxidoreductase
OFO16_RS07080	COG1953	Uracil, thiamine, allantoin
OFO16_RS07095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OFO16_RS07110	COG2059	Chromate
OFO16_RS07115	COG2059	Chromate
OFO16_RS07145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OFO16_RS07155	COG1414	Transcriptional regulator
OFO16_RS07160	COG0400	carboxylic ester hydrolase activity
OFO16_RS07170	COG5002	protein histidine kinase activity
OFO16_RS07170	COG0784	Response regulator, receiver
OFO16_RS07170	COG2198	Histidine kinase
OFO16_RS07180	COG0559	Belongs to the binding-protein-dependent transport system permease family
OFO16_RS07200	COG0829	nickel cation binding
OFO16_RS07205	COG0831	urea catabolic process
OFO16_RS07210	COG0832	Belongs to the urease beta subunit family
OFO16_RS07215	COG0804	urea catabolic process
OFO16_RS07225	COG0830	nickel cation binding
OFO16_RS07230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OFO16_RS07240	COG0471	metal ion transport
OFO16_RS07245	COG4191	Histidine kinase
OFO16_RS07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS07265	COG0814	amino acid
OFO16_RS07285	COG1132	(ABC) transporter
OFO16_RS07290	COG1132	(ABC) transporter
OFO16_RS07310	COG0443	Heat shock 70 kDa protein
OFO16_RS07360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OFO16_RS07365	COG1643	Atp-dependent helicase
OFO16_RS07380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_RS07390	COG1793	dna ligase
OFO16_RS07400	COG0534	Mate efflux family protein
OFO16_RS07405	COG0307	riboflavin synthase, alpha
OFO16_RS07415	COG3001	Fructosamine kinase
OFO16_RS07420	COG2201	protein-glutamate methylesterase activity
OFO16_RS07425	COG3706	GGDEF domain
OFO16_RS07435	COG0791	NLP P60 protein
OFO16_RS07440	COG0840	transmembrane signaling receptor activity
OFO16_RS07455	COG3148	PFAM DTW domain containing protein
OFO16_RS07465	COG3293	Transposase
OFO16_RS07485	COG0303	'Molybdopterin
OFO16_RS07495	COG3842	ATPase activity
OFO16_RS07510	COG2204	response regulator
OFO16_RS07515	COG4191	Histidine kinase
OFO16_RS07520	COG0488	(ABC) transporter
OFO16_RS07525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OFO16_RS07555	COG0243	molybdopterin cofactor binding
OFO16_RS07555	COG3383	formate dehydrogenase (NAD+) activity
OFO16_RS07560	COG0437	4 iron, 4 sulfur cluster binding
OFO16_RS07575	COG0004	ammonium transporteR
OFO16_RS07585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OFO16_RS07590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFO16_RS07600	COG1177	transmembrane transport
OFO16_RS07610	COG3842	ATPase activity
OFO16_RS07625	COG0037	tRNA processing
OFO16_RS07630	COG0589	response to stress
OFO16_RS07635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFO16_RS07650	COG2217	Heavy metal translocating P-type atpase
OFO16_RS07660	COG2010	Cytochrome c
OFO16_RS07675	COG3278	Belongs to the heme-copper respiratory oxidase family
OFO16_RS07690	COG2205	protein histidine kinase activity
OFO16_RS07690	COG0784	Response regulator, receiver
OFO16_RS07775	COG3120	sequence-specific DNA binding
OFO16_RS07780	COG1067	ATP-dependent peptidase activity
OFO16_RS07785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OFO16_RS07800	COG0488	(ABC) transporter
OFO16_RS07810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OFO16_RS07810	COG0116	Belongs to the methyltransferase superfamily
OFO16_RS07820	COG0167	dihydroorotate dehydrogenase activity
OFO16_RS07830	COG2902	Dehydrogenase
OFO16_RS07840	COG0308	aminopeptidase N
OFO16_RS07855	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
OFO16_RS07860	COG1956	GAF domain-containing protein
OFO16_RS07865	COG1132	(ABC) transporter
OFO16_RS07870	COG2995	paraquat-inducible protein a
OFO16_RS07875	COG3008	intermembrane lipid transfer
OFO16_RS07880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OFO16_RS07880	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
OFO16_RS07900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFO16_RS07905	COG1666	GTP binding
OFO16_RS07915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS07925	COG4597	amino acid ABC transporter
OFO16_RS07930	COG0765	amino acid transport
OFO16_RS07935	COG1126	abc transporter atp-binding protein
OFO16_RS07940	COG0670	Belongs to the BI1 family
OFO16_RS07950	COG2920	part of a sulfur-relay system
OFO16_RS07955	COG1254	Belongs to the acylphosphatase family
OFO16_RS07960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OFO16_RS07980	COG2885	chlorophyll binding
OFO16_RS07990	COG3706	GGDEF domain
OFO16_RS08000	COG0602	queuosine metabolic process
OFO16_RS08005	COG0561	phosphatase activity
OFO16_RS08010	COG0110	maltose O-acetyltransferase activity
OFO16_RS08030	COG3300	MHYT domain
OFO16_RS08030	COG5001	Diguanylate cyclase
OFO16_RS08070	COG2828	Protein conserved in bacteria
OFO16_RS08080	COG0372	Belongs to the citrate synthase family
OFO16_RS08085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OFO16_RS08115	COG0730	response to heat
OFO16_RS08120	COG2358	TRAP transporter, solute receptor (TAXI family
OFO16_RS08125	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS08130	COG3284	Transcriptional regulator
OFO16_RS08145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OFO16_RS08150	COG0363	glucosamine-6-phosphate deaminase activity
OFO16_RS08155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OFO16_RS08160	COG2207	Transcriptional regulator
OFO16_RS08165	COG4774	siderophore transport
OFO16_RS08170	COG4565	transcriptional regulatory protein
OFO16_RS08175	COG3290	protein histidine kinase activity
OFO16_RS08190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_RS08205	COG0527	aspartate kinase activity
OFO16_RS08215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_RS08220	COG0456	acetyltransferase
OFO16_RS08230	COG4176	ABC-type proline glycine betaine transport system permease component
OFO16_RS08235	COG2113	Glycine betaine
OFO16_RS08255	COG4221	oxidoreductase activity
OFO16_RS08265	COG0745	RESPONSE REGULATOR receiver
OFO16_RS08270	COG0642	Histidine kinase
OFO16_RS08275	COG1368	sulfuric ester hydrolase activity
OFO16_RS08310	COG1115	amino acid carrier protein
OFO16_RS08325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OFO16_RS08330	COG1280	lysine exporter protein (LysE YggA)
OFO16_RS08335	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OFO16_RS08355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OFO16_RS08360	COG1289	transmembrane transporter activity
OFO16_RS08365	COG1566	PFAM secretion protein HlyD family protein
OFO16_RS08390	COG1472	Belongs to the glycosyl hydrolase 3 family
OFO16_RS08395	COG1560	Kdo2-lipid A biosynthetic process
OFO16_RS08405	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
OFO16_RS08410	COG3063	Type IV pilus biogenesis stability protein PilW
OFO16_RS08440	COG2315	Protein conserved in bacteria
OFO16_RS08445	COG1846	Transcriptional regulator
OFO16_RS08450	COG0697	spore germination
OFO16_RS08455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_RS08460	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS08465	COG2957	Belongs to the agmatine deiminase family
OFO16_RS08475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_RS08480	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS08485	COG1396	sequence-specific DNA binding
OFO16_RS08485	COG1917	Cupin 2, conserved barrel domain protein
OFO16_RS08495	COG0174	glutamine synthetase
OFO16_RS08500	COG1757	Na H antiporter
OFO16_RS08525	COG3121	Chaperone
OFO16_RS08550	COG2824	Alkylphosphonate utilization operon protein PhnA
OFO16_RS08585	COG0346	lactoylglutathione lyase activity
OFO16_RS08615	COG1794	racemase activity, acting on amino acids and derivatives
OFO16_RS08620	COG4977	sequence-specific DNA binding
OFO16_RS08640	COG0724	RNA recognition motif
OFO16_RS08650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OFO16_RS08655	COG1882	Formate acetyltransferase
OFO16_RS08680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
OFO16_RS08685	COG4656	Part of a membrane complex involved in electron transport
OFO16_RS08690	COG3550	peptidyl-serine autophosphorylation
OFO16_RS08770	COG3706	GGDEF domain
OFO16_RS08795	COG2188	Transcriptional regulator
OFO16_RS08800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFO16_RS08800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFO16_RS08800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_RS08805	COG0383	alpha-mannosidase activity
OFO16_RS08810	COG1929	Belongs to the glycerate kinase type-1 family
OFO16_RS08820	COG3293	Transposase
OFO16_RS08825	COG1609	Transcriptional regulator
OFO16_RS08835	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_RS08845	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS08850	COG0583	DNA-binding transcription factor activity
OFO16_RS08855	COG0604	alcohol dehydrogenase
OFO16_RS08860	COG0583	DNA-binding transcription factor activity
OFO16_RS08880	COG0583	DNA-binding transcription factor activity
OFO16_RS08930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OFO16_RS08940	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
OFO16_RS08950	COG4820	ethanolamine utilization protein (EutJ)
OFO16_RS08955	COG4869	propanediol catabolic process
OFO16_RS09000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFO16_RS09010	COG3768	UPF0283 membrane protein
OFO16_RS09015	COG3106	COG3106 Predicted ATPase
OFO16_RS09030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OFO16_RS09040	COG0814	amino acid
OFO16_RS09045	COG1760	l-serine dehydratase
OFO16_RS09055	COG0720	synthase
OFO16_RS09060	COG0017	Asparaginyl-tRNA synthetase
OFO16_RS09070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OFO16_RS09080	COG1448	Aminotransferase
OFO16_RS09095	COG2176	DNA-directed DNA polymerase activity
OFO16_RS09105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_RS09115	COG1846	Transcriptional regulator
OFO16_RS09140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OFO16_RS09155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OFO16_RS09160	COG3108	Peptidase M15
OFO16_RS09165	COG2989	Protein conserved in bacteria
OFO16_RS09190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OFO16_RS09205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OFO16_RS09210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OFO16_RS09240	COG0019	diaminopimelate decarboxylase activity
OFO16_RS09280	COG0322	excinuclease ABC activity
OFO16_RS09285	COG2197	response regulator
OFO16_RS09290	COG0417	DNA replication proofreading
OFO16_RS09300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OFO16_RS09305	COG3099	Belongs to the UPF0263 family
OFO16_RS09310	COG1187	pseudouridine synthase activity
OFO16_RS09320	COG0009	L-threonylcarbamoyladenylate synthase
OFO16_RS09325	COG0613	PHP domain protein
OFO16_RS09335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OFO16_RS09340	COG0512	Glutamine amidotransferase of anthranilate synthase
OFO16_RS09345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OFO16_RS09350	COG0134	indole-3-glycerol-phosphate synthase activity
OFO16_RS09350	COG0135	phosphoribosylanthranilate isomerase activity
OFO16_RS09355	COG0133	tryptophan synthase activity
OFO16_RS09360	COG0159	tryptophan synthase activity
OFO16_RS09365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFO16_RS09370	COG0318	PFAM AMP-dependent synthetase and ligase
OFO16_RS09375	COG1301	dicarboxylic acid transport
OFO16_RS09400	COG2350	Protein conserved in bacteria
OFO16_RS09410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OFO16_RS09415	COG0583	DNA-binding transcription factor activity
OFO16_RS09430	COG5001	Diguanylate cyclase
OFO16_RS09435	COG1032	radical SAM domain protein
OFO16_RS09440	COG0745	RESPONSE REGULATOR receiver
OFO16_RS09445	COG3850	Histidine kinase
OFO16_RS09445	COG5002	protein histidine kinase activity
OFO16_RS09480	COG3118	belongs to the thioredoxin family
OFO16_RS09485	COG4232	protein-disulfide reductase activity
OFO16_RS09495	COG1902	pentaerythritol trinitrate reductase activity
OFO16_RS09500	COG3302	dmso reductase anchor subunit
OFO16_RS09505	COG0437	4 iron, 4 sulfur cluster binding
OFO16_RS09510	COG0243	molybdopterin cofactor binding
OFO16_RS09525	COG0189	ligase activity
OFO16_RS09530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OFO16_RS09540	COG2308	Evidence 4 Homologs of previously reported genes of
OFO16_RS09555	COG2308	Evidence 4 Homologs of previously reported genes of
OFO16_RS09555	COG2307	Protein conserved in bacteria
OFO16_RS09605	COG3258	Cytochrome c
OFO16_RS09610	COG2995	paraquat-inducible protein a
OFO16_RS09615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OFO16_RS09615	COG3008	intermembrane lipid transfer
OFO16_RS09620	COG3009	Protein conserved in bacteria
OFO16_RS09625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OFO16_RS09635	COG0463	Glycosyl transferase, family 2
OFO16_RS09660	COG4166	transmembrane transport
OFO16_RS09670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OFO16_RS09675	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
OFO16_RS09685	COG0539	negative regulation of cytoplasmic translation
OFO16_RS09690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OFO16_RS09695	COG0616	signal peptide processing
OFO16_RS09700	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS09715	COG0587	DNA-directed DNA polymerase activity
OFO16_RS09720	COG1940	carbohydrate kinase activity
OFO16_RS09725	COG0469	pyruvate kinase activity
OFO16_RS09730	COG4667	esterase of the alpha-beta hydrolase superfamily
OFO16_RS09745	COG0733	neurotransmitter:sodium symporter activity
OFO16_RS09760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_RS09760	COG1263	PTS System
OFO16_RS09770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_RS09770	COG1263	PTS System
OFO16_RS09770	COG2190	(PTS) system
OFO16_RS09775	COG0084	hydrolase, TatD family'
OFO16_RS09780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OFO16_RS09785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OFO16_RS09790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OFO16_RS09820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OFO16_RS09825	COG0416	fatty acid biosynthetic process
OFO16_RS09835	COG1399	metal-binding, possibly nucleic acid-binding protein
OFO16_RS09840	COG0424	maF-like protein
OFO16_RS09845	COG0564	pseudouridine synthase activity
OFO16_RS09850	COG1530	ribonuclease E activity
OFO16_RS09855	COG0659	secondary active sulfate transmembrane transporter activity
OFO16_RS09860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OFO16_RS09865	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
OFO16_RS09875	COG0572	uridine kinase
OFO16_RS09880	COG0489	protein tyrosine kinase activity
OFO16_RS09885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFO16_RS09885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFO16_RS09895	COG2186	Transcriptional regulator
OFO16_RS09900	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OFO16_RS09905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OFO16_RS09910	COG0653	protein targeting
OFO16_RS09915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFO16_RS09920	COG2199	diguanylate cyclase activity
OFO16_RS09925	COG0366	Alpha amylase catalytic
OFO16_RS09930	COG1122	ATPase activity
OFO16_RS09935	COG4120	Belongs to the binding-protein-dependent transport system permease family
OFO16_RS09945	COG3092	negative regulation of chromosome organization
OFO16_RS09950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OFO16_RS09955	COG0857	belongs to the CobB CobQ family
OFO16_RS09955	COG0280	phosphate acetyltransferase
OFO16_RS09965	COG3174	membrane
OFO16_RS09970	COG0435	Glutathione S-transferase
OFO16_RS09980	COG0444	Belongs to the ABC transporter superfamily
OFO16_RS09985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_RS09990	COG0601	transmembrane transport
OFO16_RS10000	COG3293	Transposase
OFO16_RS10005	COG0314	molybdopterin synthase activity
OFO16_RS10010	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OFO16_RS10015	COG0315	cyclic pyranopterin monophosphate synthase activity
OFO16_RS10020	COG0521	Mo-molybdopterin cofactor biosynthetic process
OFO16_RS10025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OFO16_RS10030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OFO16_RS10035	COG2198	Histidine kinase
OFO16_RS10040	COG2204	response regulator
OFO16_RS10045	COG0556	nucleotide-excision repair
OFO16_RS10055	COG4657	Part of a membrane complex involved in electron transport
OFO16_RS10060	COG2878	Part of a membrane complex involved in electron transport
OFO16_RS10065	COG4656	Part of a membrane complex involved in electron transport
OFO16_RS10070	COG4658	electron transport chain
OFO16_RS10075	COG4659	FMN binding
OFO16_RS10080	COG4660	Part of a membrane complex involved in electron transport
OFO16_RS10085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OFO16_RS10095	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OFO16_RS10110	COG0346	lactoylglutathione lyase activity
OFO16_RS10120	COG2885	chlorophyll binding
OFO16_RS10125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OFO16_RS10130	COG2056	Na+-H+ antiporter family
OFO16_RS10135	COG3385	transposase activity
OFO16_RS10145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OFO16_RS10160	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS10165	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS10165	COG1454	alcohol dehydrogenase
OFO16_RS10170	COG2095	MarC family integral membrane protein
OFO16_RS10175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFO16_RS10180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OFO16_RS10185	COG1757	Na H antiporter
OFO16_RS10205	COG3081	Nucleoid-associated protein
OFO16_RS10210	COG3082	Protein of unknown function (DUF1414)
OFO16_RS10240	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OFO16_RS10250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFO16_RS10255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFO16_RS10260	COG1120	ATPase activity
OFO16_RS10265	COG1522	sequence-specific DNA binding
OFO16_RS10270	COG0626	cystathionine gamma-synthase activity
OFO16_RS10275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS10280	COG0765	amino acid transport
OFO16_RS10290	COG0123	including yeast histone deacetylase and acetoin utilization protein
OFO16_RS10300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OFO16_RS10305	COG0778	Nitroreductase
OFO16_RS10310	COG3385	transposase activity
OFO16_RS10315	COG0446	pyridine nucleotide-disulphide oxidoreductase
OFO16_RS10315	COG1902	pentaerythritol trinitrate reductase activity
OFO16_RS10320	COG0616	signal peptide processing
OFO16_RS10325	COG0252	asparaginase activity
OFO16_RS10330	COG3139	Protein of unknown function (DUF1315)
OFO16_RS10340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFO16_RS10345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFO16_RS10355	COG2226	methyltransferase
OFO16_RS10370	COG1785	Belongs to the alkaline phosphatase family
OFO16_RS10380	COG0668	transmembrane transport
OFO16_RS10390	COG2261	transglycosylase associated protein
OFO16_RS10400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OFO16_RS10405	COG3385	transposase activity
OFO16_RS10410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OFO16_RS10425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OFO16_RS10430	COG2832	Protein of unknown function (DUF454)
OFO16_RS10440	COG0745	RESPONSE REGULATOR receiver
OFO16_RS10445	COG0583	DNA-binding transcription factor activity
OFO16_RS10460	COG5492	domain, Protein
OFO16_RS10465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OFO16_RS10470	COG1286	toxin biosynthetic process
OFO16_RS10475	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
OFO16_RS10480	COG0285	dihydrofolate synthase activity
OFO16_RS10485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OFO16_RS10490	COG0101	tRNA pseudouridine synthase activity
OFO16_RS10500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OFO16_RS10505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OFO16_RS10510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OFO16_RS10520	COG0431	NADPH-dependent FMN reductase
OFO16_RS10530	COG3101	peptidyl-lysine hydroxylation
OFO16_RS10535	COG2860	membrane
OFO16_RS10540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OFO16_RS10545	COG2890	protein-(glutamine-N5) methyltransferase activity
OFO16_RS10550	COG2840	Smr protein MutS2
OFO16_RS10555	COG2062	phosphohistidine phosphatase, SixA
OFO16_RS10570	COG1024	Enoyl-CoA hydratase
OFO16_RS10570	COG1250	3-hydroxyacyl-CoA dehydrogenase
OFO16_RS10575	COG0183	Belongs to the thiolase family
OFO16_RS10615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OFO16_RS10620	COG1138	Cytochrome C-type biogenesis protein
OFO16_RS10625	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OFO16_RS10630	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OFO16_RS10635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OFO16_RS10640	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OFO16_RS10645	COG4133	protoheme IX ABC transporter activity
OFO16_RS10655	COG0835	chemotaxis
OFO16_RS10665	COG1192	Involved in chromosome partitioning
OFO16_RS10670	COG2201	protein-glutamate methylesterase activity
OFO16_RS10675	COG0643	Histidine kinase
OFO16_RS10675	COG0784	Response regulator, receiver
OFO16_RS10675	COG2198	Histidine kinase
OFO16_RS10680	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
OFO16_RS10720	COG1987	bacterial-type flagellum assembly
OFO16_RS10770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OFO16_RS10780	COG1677	Flagellar hook-basal body complex protein FliE
OFO16_RS10800	COG1516	flagellar protein fliS
OFO16_RS10810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OFO16_RS10815	COG1334	flagellar protein FlaG
OFO16_RS10820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_RS10825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_RS10830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_RS10835	COG2837	iron assimilation
OFO16_RS10865	COG1393	Belongs to the ArsC family
OFO16_RS10870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OFO16_RS10885	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
OFO16_RS10890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OFO16_RS10895	COG2716	regulation of RNA biosynthetic process
OFO16_RS10925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OFO16_RS10935	COG3547	Transposase (IS116 IS110 IS902 family)
OFO16_RS10945	COG3385	transposase activity
OFO16_RS10980	COG1462	curli production assembly transport component CsgG
OFO16_RS11010	COG3293	Transposase
OFO16_RS11015	COG3547	Transposase (IS116 IS110 IS902 family)
OFO16_RS11065	COG4783	chaperone-mediated protein folding
OFO16_RS11070	COG1393	Belongs to the ArsC family
OFO16_RS11090	COG2233	PERMEase
OFO16_RS11095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OFO16_RS11100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OFO16_RS11105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OFO16_RS11110	COG0121	glutamine amidotransferase
OFO16_RS11115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OFO16_RS11120	COG1960	acyl-CoA dehydrogenase activity
OFO16_RS11140	COG0328	RNA-DNA hybrid ribonuclease activity
OFO16_RS11145	COG2226	methyltransferase
OFO16_RS11150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OFO16_RS11155	COG0741	lytic transglycosylase activity
OFO16_RS11155	COG1388	LysM domain
OFO16_RS11165	COG3021	interspecies interaction between organisms
OFO16_RS11170	COG0347	Belongs to the P(II) protein family
OFO16_RS11180	COG0037	tRNA processing
OFO16_RS11185	COG0825	malonyl-CoA metabolic process
OFO16_RS11190	COG0587	DNA-directed DNA polymerase activity
OFO16_RS11200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFO16_RS11205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFO16_RS11215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFO16_RS11220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
OFO16_RS11230	COG0750	zinc metalloprotease
OFO16_RS11235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OFO16_RS11240	COG0575	Belongs to the CDS family
OFO16_RS11245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OFO16_RS11250	COG0233	cytoplasmic translational termination
OFO16_RS11255	COG0528	UMP kinase activity
OFO16_RS11260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OFO16_RS11270	COG0024	Methionine aminopeptidase
OFO16_RS11275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
OFO16_RS11285	COG0564	pseudouridine synthase activity
OFO16_RS11315	COG1671	Belongs to the UPF0178 family
OFO16_RS11320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OFO16_RS11330	COG0254	rRNA binding
OFO16_RS11335	COG1720	tRNA m6t6A37 methyltransferase activity
OFO16_RS11355	COG0733	neurotransmitter:sodium symporter activity
OFO16_RS11365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFO16_RS11370	COG0514	ATP-dependent DNA helicase (RecQ)
OFO16_RS11375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OFO16_RS11385	COG2991	Protein conserved in bacteria
OFO16_RS11390	COG1477	protein flavinylation
OFO16_RS11395	COG2871	sodium ion transport
OFO16_RS11400	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFO16_RS11405	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFO16_RS11410	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFO16_RS11415	COG1805	sodium ion transport
OFO16_RS11420	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFO16_RS11430	COG0271	Belongs to the BolA IbaG family
OFO16_RS11435	COG2813	Specifically methylates the guanine in position
OFO16_RS11460	COG1595	DNA-templated transcription, initiation
OFO16_RS11475	COG3248	Nucleoside-binding outer membrane protein
OFO16_RS11480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OFO16_RS11485	COG0693	protein deglycase activity
OFO16_RS11490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OFO16_RS11495	COG3706	GGDEF domain
OFO16_RS11500	COG2166	iron-sulfur cluster assembly
OFO16_RS11505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OFO16_RS11510	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
OFO16_RS11520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OFO16_RS11520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OFO16_RS11525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OFO16_RS11530	COG1074	ATP-dependent DNA helicase activity
OFO16_RS11535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OFO16_RS11565	COG3141	response to X-ray
OFO16_RS11570	COG2171	N-acyltransferase activity
OFO16_RS11575	COG0584	glycerophosphoryl diester phosphodiesterase
OFO16_RS11580	COG2271	Major facilitator Superfamily
OFO16_RS11585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OFO16_RS11590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OFO16_RS11595	COG1349	DNA-binding transcription factor activity
OFO16_RS11600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OFO16_RS11620	COG1609	Transcriptional regulator
OFO16_RS11625	COG1609	Transcriptional regulator
OFO16_RS11630	COG0583	DNA-binding transcription factor activity
OFO16_RS11700	COG4964	Belongs to the GSP D family
OFO16_RS11730	COG2169	Transcriptional regulator
OFO16_RS11735	COG1022	Amp-dependent synthetase and ligase
OFO16_RS11750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OFO16_RS11755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OFO16_RS11765	COG0560	Phosphoserine phosphatase
OFO16_RS11775	COG0813	purine-nucleoside phosphorylase activity
OFO16_RS11780	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OFO16_RS11785	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OFO16_RS11790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OFO16_RS11795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFO16_RS11800	COG0084	hydrolase, TatD family'
OFO16_RS11810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OFO16_RS11825	COG3153	acetyltransferase
OFO16_RS11830	COG3154	lipid carrier protein
OFO16_RS11840	COG0826	peptidase U32
OFO16_RS11845	COG0826	peptidase U32
OFO16_RS11850	COG0534	Mate efflux family protein
OFO16_RS11860	COG1185	polyribonucleotide nucleotidyltransferase activity
OFO16_RS11865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OFO16_RS11870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OFO16_RS11875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OFO16_RS11880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OFO16_RS11885	COG0195	Participates in both transcription termination and antitermination
OFO16_RS11890	COG0779	Required for maturation of 30S ribosomal subunits
OFO16_RS11905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OFO16_RS11915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OFO16_RS11920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OFO16_RS11925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OFO16_RS11930	COG1534	Rna-binding protein
OFO16_RS11935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFO16_RS11940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
OFO16_RS11945	COG2027	D-alanyl-D-alanine carboxypeptidase
OFO16_RS11955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OFO16_RS11960	COG0739	heme binding
OFO16_RS11975	COG0316	Belongs to the HesB IscA family
OFO16_RS11980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OFO16_RS11985	COG0628	permease
OFO16_RS11990	COG2813	Specifically methylates the guanine in position
OFO16_RS11995	COG0784	Response regulator, receiver
OFO16_RS11995	COG2205	protein histidine kinase activity
OFO16_RS12000	COG0747	negative chemotaxis
OFO16_RS12010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_RS12015	COG0444	Belongs to the ABC transporter superfamily
OFO16_RS12020	COG4608	Belongs to the ABC transporter superfamily
OFO16_RS12030	COG2971	BadF BadG BcrA BcrD
OFO16_RS12045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OFO16_RS12050	COG3842	ATPase activity
OFO16_RS12060	COG1840	ABC-type Fe3 transport system, periplasmic component
OFO16_RS12065	COG0004	ammonium transporteR
OFO16_RS12075	COG3112	Uncharacterised protein family (UPF0231)
OFO16_RS12080	COG3835	regulator
OFO16_RS12085	COG2610	gluconate transmembrane transporter activity
OFO16_RS12090	COG1929	Belongs to the glycerate kinase type-1 family
OFO16_RS12095	COG1049	propionate catabolic process, 2-methylcitrate cycle
OFO16_RS12100	COG1752	Esterase of the alpha-beta hydrolase superfamily
OFO16_RS12105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OFO16_RS12110	COG1643	Atp-dependent helicase
OFO16_RS12115	COG1489	DNA binding
OFO16_RS12125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OFO16_RS12135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OFO16_RS12140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OFO16_RS12145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OFO16_RS12150	COG0842	Transport permease protein
OFO16_RS12155	COG1131	(ABC) transporter
OFO16_RS12160	COG0659	secondary active sulfate transmembrane transporter activity
OFO16_RS12165	COG0288	reversible hydration of carbon dioxide
OFO16_RS12170	COG3002	Belongs to the UPF0753 family
OFO16_RS12175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OFO16_RS12180	COG0583	DNA-binding transcription factor activity
OFO16_RS12195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFO16_RS12200	COG0508	dehydrogenase complex catalyzes the overall conversion of
OFO16_RS12205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
OFO16_RS12210	COG2186	Transcriptional regulator
OFO16_RS12220	COG0157	Belongs to the NadC ModD family
OFO16_RS12225	COG4969	Belongs to the N-Me-Phe pilin family
OFO16_RS12230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFO16_RS12235	COG1459	type II secretion system
OFO16_RS12245	COG0237	dephospho-CoA kinase activity
OFO16_RS12250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
OFO16_RS12255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OFO16_RS12265	COG0336	Belongs to the RNA methyltransferase TrmD family
OFO16_RS12270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OFO16_RS12275	COG0228	four-way junction DNA binding
OFO16_RS12280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OFO16_RS12285	COG4137	Cytochrome C assembly protein
OFO16_RS12290	COG4536	flavin adenine dinucleotide binding
OFO16_RS12295	COG1854	S-ribosylhomocysteine lyase activity
OFO16_RS12305	COG2918	glutathione biosynthetic process
OFO16_RS12310	COG0612	Peptidase, M16
OFO16_RS12315	COG1238	metal cluster binding
OFO16_RS12325	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
OFO16_RS12330	COG5016	pyruvate
OFO16_RS12330	COG0511	ligase activity, forming carbon-carbon bonds
OFO16_RS12335	COG3630	sodium ion export across plasma membrane
OFO16_RS12400	COG0527	aspartate kinase activity
OFO16_RS12405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OFO16_RS12420	COG1546	Belongs to the CinA family
OFO16_RS12425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OFO16_RS12430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OFO16_RS12440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OFO16_RS12445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OFO16_RS12460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OFO16_RS12465	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OFO16_RS12470	COG0148	phosphopyruvate hydratase activity
OFO16_RS12475	COG0504	CTP synthase activity
OFO16_RS12480	COG3956	TIGRFAM MazG family protein
OFO16_RS12485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OFO16_RS12490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OFO16_RS12500	COG0736	holo-[acyl-carrier-protein] synthase activity
OFO16_RS12505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OFO16_RS12510	COG1381	Involved in DNA repair and RecF pathway recombination
OFO16_RS12515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OFO16_RS12530	COG0481	GTPase activity
OFO16_RS12535	COG3086	response to oxidative stress
OFO16_RS12550	COG1595	DNA-templated transcription, initiation
OFO16_RS12555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OFO16_RS12565	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OFO16_RS12570	COG0354	folic acid binding
OFO16_RS12585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFO16_RS12590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFO16_RS12595	COG3079	Belongs to the UPF0149 family
OFO16_RS12600	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OFO16_RS12610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OFO16_RS12615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OFO16_RS12620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OFO16_RS12630	COG0583	DNA-binding transcription factor activity
OFO16_RS12635	COG1279	arginine transmembrane transporter activity
OFO16_RS12640	COG0668	transmembrane transport
OFO16_RS12645	COG0191	fructose-bisphosphate aldolase activity
OFO16_RS12650	COG0126	phosphoglycerate kinase activity
OFO16_RS12655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFO16_RS12660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OFO16_RS12665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OFO16_RS12680	COG2356	endonuclease I
OFO16_RS12685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OFO16_RS12690	COG0189	ligase activity
OFO16_RS12695	COG1678	Uncharacterized ACR, COG1678
OFO16_RS12700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OFO16_RS12715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OFO16_RS12720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OFO16_RS12725	COG0762	integral membrane protein
OFO16_RS12740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OFO16_RS12745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OFO16_RS12750	COG2066	Belongs to the glutaminase family
OFO16_RS12770	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
OFO16_RS12775	COG0741	lytic transglycosylase activity
OFO16_RS12885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OFO16_RS12890	COG0300	oxidoreductase activity
OFO16_RS12930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFO16_RS12935	COG0640	Transcriptional regulator
OFO16_RS12945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OFO16_RS12950	COG0573	inorganic phosphate transmembrane transporter activity
OFO16_RS12955	COG0581	inorganic phosphate transmembrane transporter activity
OFO16_RS12965	COG0704	Plays a role in the regulation of phosphate uptake
OFO16_RS12985	COG0798	PFAM Bile acid sodium symporter
OFO16_RS12990	COG0640	Transcriptional regulator
OFO16_RS13030	COG3293	Transposase
OFO16_RS13155	COG0300	oxidoreductase activity
OFO16_RS13170	COG0795	lipopolysaccharide-transporting ATPase activity
OFO16_RS13175	COG0795	lipopolysaccharide-transporting ATPase activity
OFO16_RS13180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OFO16_RS13185	COG2927	DNA polymerase III (CHI subunit)
OFO16_RS13190	COG0525	valine-tRNA ligase activity
OFO16_RS13215	COG2235	arginine
OFO16_RS13225	COG0540	Belongs to the ATCase OTCase family
OFO16_RS13230	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
OFO16_RS13235	COG0251	oxidation-reduction process
OFO16_RS13240	COG0204	Acyl-transferase
OFO16_RS13245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OFO16_RS13250	COG5007	Belongs to the BolA IbaG family
OFO16_RS13260	COG2854	intermembrane phospholipid transfer
OFO16_RS13265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OFO16_RS13270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OFO16_RS13275	COG1127	ABC transporter
OFO16_RS13285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OFO16_RS13285	COG0517	IMP dehydrogenase activity
OFO16_RS13295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OFO16_RS13300	COG1137	ATPase activity
OFO16_RS13310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OFO16_RS13315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_RS13320	COG1660	Displays ATPase and GTPase activities
OFO16_RS13325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_RS13330	COG2239	Acts as a magnesium transporter
OFO16_RS13335	COG0312	modulator of DNA gyrase
OFO16_RS13340	COG3028	Belongs to the UPF0307 family
OFO16_RS13345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OFO16_RS13350	COG0564	pseudouridine synthase activity
OFO16_RS13360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OFO16_RS13365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OFO16_RS13370	COG0312	modulator of DNA gyrase
OFO16_RS13375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OFO16_RS13380	COG3164	Protein of unknown function
OFO16_RS13390	COG0424	maF-like protein
OFO16_RS13395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OFO16_RS13400	COG1792	Involved in formation and maintenance of cell shape
OFO16_RS13405	COG1077	Cell shape determining protein MreB Mrl
OFO16_RS13440	COG2165	general secretion pathway protein
OFO16_RS13450	COG1459	type II secretion system
OFO16_RS13455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFO16_RS13465	COG3409	Peptidoglycan-binding domain 1 protein
OFO16_RS13465	COG3267	Type II secretory pathway component ExeA
OFO16_RS13490	COG2200	EAL domain
OFO16_RS13490	COG2199	diguanylate cyclase activity
OFO16_RS13495	COG0629	single-stranded DNA binding
OFO16_RS13510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OFO16_RS13520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OFO16_RS13525	COG0527	aspartate kinase activity
OFO16_RS13530	COG0646	methionine synthase
OFO16_RS13530	COG1410	methionine synthase
OFO16_RS13540	COG3385	transposase activity
OFO16_RS13565	COG0175	sulfate reduction
OFO16_RS13570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OFO16_RS13575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OFO16_RS13595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFO16_RS13600	COG0735	belongs to the Fur family
OFO16_RS13610	COG0166	Belongs to the GPI family
OFO16_RS13615	COG0432	Pfam Uncharacterised protein family UPF0047
OFO16_RS13620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OFO16_RS13645	COG2965	DNA replication, synthesis of RNA primer
OFO16_RS13650	COG0360	Binds together with S18 to 16S ribosomal RNA
OFO16_RS13655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OFO16_RS13660	COG0338	D12 class N6 adenine-specific DNA methyltransferase
OFO16_RS13670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OFO16_RS13675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OFO16_RS13705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OFO16_RS13715	COG0678	peroxiredoxin activity
OFO16_RS13715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OFO16_RS13720	COG0165	Argininosuccinate lyase
OFO16_RS13720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OFO16_RS13725	COG0137	argininosuccinate synthase activity
OFO16_RS13730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OFO16_RS13735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OFO16_RS13745	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OFO16_RS13755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OFO16_RS13760	COG0460	homoserine dehydrogenase
OFO16_RS13760	COG0527	aspartate kinase activity
OFO16_RS13765	COG0626	cystathionine gamma-synthase activity
OFO16_RS13775	COG0281	malic enzyme
OFO16_RS13795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OFO16_RS13815	COG2923	Belongs to the DsrF TusC family
OFO16_RS13820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OFO16_RS13825	COG2964	Protein conserved in bacteria
OFO16_RS13830	COG0545	Peptidyl-prolyl cis-trans isomerase
OFO16_RS13840	COG2900	Belongs to the SlyX family
OFO16_RS13850	COG1047	Peptidyl-prolyl cis-trans
OFO16_RS13865	COG2249	NAD(P)H dehydrogenase (quinone) activity
OFO16_RS13870	COG0488	(ABC) transporter
OFO16_RS13880	COG0429	hydrolase of the alpha beta-hydrolase fold
OFO16_RS13890	COG3954	Phosphoribulokinase
OFO16_RS13895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFO16_RS13905	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS13915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OFO16_RS13920	COG0512	Glutamine amidotransferase of anthranilate synthase
OFO16_RS13925	COG3385	transposase activity
OFO16_RS13930	COG0180	Tryptophanyl-tRNA synthetase
OFO16_RS13935	COG0546	phosphoglycolate phosphatase activity
OFO16_RS13940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OFO16_RS13945	COG0557	exoribonuclease II activity
OFO16_RS13950	COG1959	2 iron, 2 sulfur cluster binding
OFO16_RS13955	COG1017	nitric oxide dioxygenase activity
OFO16_RS13955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFO16_RS13960	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
OFO16_RS13970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OFO16_RS13975	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
OFO16_RS13980	COG0330	HflC and HflK could
OFO16_RS13985	COG0330	HflC and HflK could
OFO16_RS13990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OFO16_RS14000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OFO16_RS14005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OFO16_RS14010	COG0860	N-Acetylmuramoyl-L-alanine amidase
OFO16_RS14015	COG0802	atpase or kinase
OFO16_RS14020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OFO16_RS14085	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OFO16_RS14090	COG1162	GTPase activity
OFO16_RS14100	COG0471	metal ion transport
OFO16_RS14100	COG3273	potassium ion transport
OFO16_RS14110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OFO16_RS14115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFO16_RS14125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OFO16_RS14130	COG1045	serine acetyltransferase
OFO16_RS14135	COG4942	peptidase
OFO16_RS14155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OFO16_RS14160	COG1053	succinate dehydrogenase
OFO16_RS14165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OFO16_RS14180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OFO16_RS14185	COG1509	lysine 2,3-aminomutase activity
OFO16_RS14215	COG0534	Mate efflux family protein
OFO16_RS14220	COG0205	6-phosphofructokinase activity
OFO16_RS14230	COG3678	ATP-independent chaperone mediated protein folding
OFO16_RS14235	COG0745	RESPONSE REGULATOR receiver
OFO16_RS14240	COG2205	protein histidine kinase activity
OFO16_RS14245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OFO16_RS14255	COG1027	Aspartate ammonia-lyase
OFO16_RS14260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OFO16_RS14265	COG4232	protein-disulfide reductase activity
OFO16_RS14275	COG3263	regulation of cellular component size
OFO16_RS14285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_RS14300	COG0784	Response regulator, receiver
OFO16_RS14300	COG2198	Histidine kinase
OFO16_RS14300	COG2205	protein histidine kinase activity
OFO16_RS14305	COG2814	Major facilitator Superfamily
OFO16_RS14320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OFO16_RS14325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OFO16_RS14330	COG0511	ligase activity, forming carbon-carbon bonds
OFO16_RS14335	COG0439	Biotin carboxylase
OFO16_RS14340	COG2264	protein methyltransferase activity
OFO16_RS14345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFO16_RS14350	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OFO16_RS14435	COG3710	Transcriptional regulator
OFO16_RS14445	COG0138	bifunctional purine biosynthesis protein purh
OFO16_RS14450	COG0151	Belongs to the GarS family
OFO16_RS14465	COG1253	flavin adenine dinucleotide binding
OFO16_RS14470	COG3068	Protein conserved in bacteria
OFO16_RS14480	COG1573	uracil-dna glycosylase
OFO16_RS14485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OFO16_RS14490	COG2816	NAD+ diphosphatase activity
OFO16_RS14495	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
OFO16_RS14500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OFO16_RS14505	COG0085	RNA polymerase activity
OFO16_RS14510	COG0222	ribosome binding
OFO16_RS14515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OFO16_RS14530	COG0250	Participates in transcription elongation, termination and antitermination
OFO16_RS14535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OFO16_RS14575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OFO16_RS14585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OFO16_RS14660	COG4206	TonB-dependent receptor
OFO16_RS14680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFO16_RS14685	COG0534	Mate efflux family protein
OFO16_RS14690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
OFO16_RS14695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OFO16_RS14700	COG2937	Belongs to the GPAT DAPAT family
OFO16_RS14710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OFO16_RS14715	COG3161	chorismate lyase activity
OFO16_RS14720	COG1580	Controls the rotational direction of flagella during chemotaxis
OFO16_RS14725	COG0705	Rhomboid family
OFO16_RS14740	COG2177	Part of the ABC transporter FtsEX involved in
OFO16_RS14745	COG2884	Cell division ATP-binding protein ftsE
OFO16_RS14750	COG0552	protein localization to endoplasmic reticulum
OFO16_RS14755	COG0742	ribosomal rna small subunit methyltransferase
OFO16_RS14800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFO16_RS14805	COG0640	Transcriptional regulator
OFO16_RS14815	COG1280	lysine exporter protein (LysE YggA)
OFO16_RS14820	COG2267	carboxylic ester hydrolase activity
OFO16_RS14825	COG0561	phosphatase activity
OFO16_RS14840	COG3148	PFAM DTW domain containing protein
OFO16_RS14845	COG1011	Hydrolase
OFO16_RS14850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OFO16_RS14860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OFO16_RS14865	COG0019	diaminopimelate decarboxylase activity
OFO16_RS14875	COG1965	Belongs to the frataxin family
OFO16_RS14880	COG3072	Adenylate cyclase
OFO16_RS14885	COG0181	hydroxymethylbilane synthase activity
OFO16_RS14890	COG1587	Uroporphyrinogen-III synthase
OFO16_RS14895	COG2959	enzyme of heme biosynthesis
OFO16_RS14900	COG3071	HemY protein
OFO16_RS14945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
OFO16_RS14960	COG3118	belongs to the thioredoxin family
OFO16_RS14965	COG0513	Belongs to the DEAD box helicase family
OFO16_RS14970	COG0248	Ppx GppA phosphatase
OFO16_RS14975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OFO16_RS14985	COG0514	ATP-dependent DNA helicase (RecQ)
OFO16_RS14990	COG2962	Rard protein
OFO16_RS15000	COG1280	lysine exporter protein (LysE YggA)
OFO16_RS15005	COG0405	Gamma-glutamyltransferase
OFO16_RS15010	COG0210	DNA helicase
OFO16_RS15020	COG3220	belongs to the UPF0276 family
OFO16_RS15040	COG2814	Major facilitator Superfamily
OFO16_RS15050	COG0006	proline dipeptidase activity
OFO16_RS15050	COG0006	proline dipeptidase activity
OFO16_RS15055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OFO16_RS15060	COG2022	thiamine diphosphate biosynthetic process
OFO16_RS15065	COG2104	thiamine diphosphate biosynthetic process
OFO16_RS15070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OFO16_RS15080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OFO16_RS15085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OFO16_RS15090	COG2132	Multicopper oxidase
OFO16_RS15140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OFO16_RS15150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OFO16_RS15155	COG0408	coproporphyrinogen oxidase activity
OFO16_RS15160	COG0009	L-threonylcarbamoyladenylate synthase
OFO16_RS15165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OFO16_RS15170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OFO16_RS15175	COG0551	DNA topoisomerase type I activity
OFO16_RS15180	COG2922	Belongs to the Smg family
OFO16_RS15185	COG0758	DNA mediated transformation
OFO16_RS15205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OFO16_RS15205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OFO16_RS15210	COG0569	domain protein
OFO16_RS15215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFO16_RS15225	COG1272	protein, Hemolysin III
OFO16_RS15230	COG4326	sporulation control protein
OFO16_RS15240	COG3084	Protein conserved in bacteria
OFO16_RS15250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OFO16_RS15255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFO16_RS15260	COG0204	Acyl-transferase
OFO16_RS15285	COG0270	DNA (cytosine-5-)-methyltransferase activity
OFO16_RS15350	COG3978	acetolactate synthase activity
OFO16_RS15365	COG0583	DNA-binding transcription factor activity
OFO16_RS15370	COG2814	Major facilitator Superfamily
OFO16_RS15375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS15380	COG0765	amino acid transport
OFO16_RS15395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OFO16_RS15400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OFO16_RS15405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OFO16_RS15410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OFO16_RS15415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OFO16_RS15420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OFO16_RS15430	COG0356	it plays a direct role in the translocation of protons across the membrane
OFO16_RS15435	COG3312	ion transport
OFO16_RS15440	COG1475	DNA binding
OFO16_RS15445	COG1192	Involved in chromosome partitioning
OFO16_RS15455	COG0445	tRNA wobble uridine modification
OFO16_RS15460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OFO16_RS15470	COG0706	membrane insertase activity
OFO16_RS15480	COG0594	ribonuclease P activity
OFO16_RS15490	COG1126	abc transporter atp-binding protein
OFO16_RS15510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OFO16_RS15510	COG2111	Na H antiporter
OFO16_RS15515	COG1006	Multisubunit Na H antiporter MnhC subunit
OFO16_RS15520	COG0651	ATP synthesis coupled electron transport
OFO16_RS15525	COG1863	multisubunit Na H antiporter MnhE subunit
OFO16_RS15530	COG2212	antiporter activity
OFO16_RS15535	COG1320	monovalent cation:proton antiporter activity
OFO16_RS15550	COG0513	Belongs to the DEAD box helicase family
OFO16_RS15560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OFO16_RS15670	COG3706	GGDEF domain
OFO16_RS15690	COG3550	peptidyl-serine autophosphorylation
OFO16_RS15700	COG1733	regulation of RNA biosynthetic process
OFO16_RS15710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OFO16_RS15735	COG0697	spore germination
OFO16_RS15740	COG5413	integral membrane protein
OFO16_RS15755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OFO16_RS15760	COG1960	acyl-CoA dehydrogenase activity
OFO16_RS15770	COG0183	Belongs to the thiolase family
OFO16_RS15780	COG1960	acyl-CoA dehydrogenase activity
OFO16_RS15785	COG1024	Enoyl-CoA hydratase
OFO16_RS15790	COG1024	Enoyl-CoA hydratase
OFO16_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS15805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OFO16_RS15810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OFO16_RS15815	COG1845	cytochrome c oxidase, subunit III
OFO16_RS15820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OFO16_RS15825	COG0109	protoheme IX farnesyltransferase activity
OFO16_RS15830	COG1902	pentaerythritol trinitrate reductase activity
OFO16_RS15840	COG0531	amino acid
OFO16_RS15845	COG2040	homocysteine
OFO16_RS15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS15875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OFO16_RS15900	COG1126	abc transporter atp-binding protein
OFO16_RS15905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS15910	COG4215	(ABC) transporter
OFO16_RS15915	COG4160	amino acid transport
OFO16_RS15920	COG1115	amino acid carrier protein
OFO16_RS15955	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
OFO16_RS15965	COG0583	DNA-binding transcription factor activity
OFO16_RS15975	COG3344	reverse transcriptase
OFO16_RS15980	COG3344	reverse transcriptase
OFO16_RS15990	COG3293	Transposase
OFO16_RS16010	COG3383	formate dehydrogenase (NAD+) activity
OFO16_RS16020	COG0543	2 iron, 2 sulfur cluster binding
OFO16_RS16025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OFO16_RS16025	COG0574	Belongs to the PEP-utilizing enzyme family
OFO16_RS16040	COG0022	dehydrogenase e1 component
OFO16_RS16040	COG0508	dehydrogenase complex catalyzes the overall conversion of
OFO16_RS16045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OFO16_RS16060	COG4702	Belongs to the UPF0303 family
OFO16_RS16065	COG0673	inositol 2-dehydrogenase activity
OFO16_RS16070	COG1349	DNA-binding transcription factor activity
OFO16_RS16075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OFO16_RS16080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OFO16_RS16085	COG1882	Formate acetyltransferase
OFO16_RS16090	COG1349	DNA-binding transcription factor activity
OFO16_RS16130	COG0443	Heat shock 70 kDa protein
OFO16_RS16160	COG0814	amino acid
OFO16_RS16170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS16175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OFO16_RS16335	COG0509	glycine decarboxylation via glycine cleavage system
OFO16_RS16340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OFO16_RS16350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OFO16_RS16360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_RS16375	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OFO16_RS16375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFO16_RS16375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFO16_RS16380	COG1105	Belongs to the carbohydrate kinase PfkB family
OFO16_RS16385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_RS16385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_RS16390	COG1609	Transcriptional regulator
OFO16_RS16405	COG0765	amino acid transport
OFO16_RS16410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS16415	COG0765	amino acid transport
OFO16_RS16420	COG1126	abc transporter atp-binding protein
OFO16_RS16430	COG1979	alcohol dehydrogenase
OFO16_RS16435	COG2207	Transcriptional regulator
OFO16_RS16445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OFO16_RS16450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OFO16_RS16455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_RS16470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_RS16475	COG0840	transmembrane signaling receptor activity
OFO16_RS16480	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
OFO16_RS16485	COG0513	Belongs to the DEAD box helicase family
OFO16_RS16490	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OFO16_RS16505	COG3038	cytochrome b561
OFO16_RS16510	COG2353	YceI-like domain
OFO16_RS16515	COG2116	formate transmembrane transporter activity
OFO16_RS16520	COG0583	DNA-binding transcription factor activity
OFO16_RS16530	COG3593	DNA synthesis involved in DNA repair
OFO16_RS16535	COG0737	Belongs to the 5'-nucleotidase family
OFO16_RS16540	COG0861	Integral membrane protein TerC family
OFO16_RS16550	COG3293	Transposase
OFO16_RS16560	COG2267	carboxylic ester hydrolase activity
OFO16_RS16565	COG2067	long-chain fatty acid transport protein
OFO16_RS16580	COG2050	protein possibly involved in aromatic compounds catabolism
OFO16_RS16600	COG1324	tolerance protein
OFO16_RS16625	COG3300	MHYT domain
OFO16_RS16625	COG5001	Diguanylate cyclase
OFO16_RS16630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OFO16_RS16640	COG4181	ATPase activity
OFO16_RS16645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OFO16_RS16740	COG1984	allophanate hydrolase subunit 2
OFO16_RS16745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OFO16_RS16750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OFO16_RS16755	COG3447	MASE1 domain protein
OFO16_RS16755	COG5002	protein histidine kinase activity
OFO16_RS16755	COG5001	Diguanylate cyclase
OFO16_RS16765	COG0583	DNA-binding transcription factor activity
OFO16_RS16770	COG1042	CoA-binding domain protein
OFO16_RS16770	COG0045	succinate-CoA ligase (ADP-forming) activity
OFO16_RS16770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFO16_RS16780	COG3385	transposase activity
OFO16_RS16785	COG1181	Belongs to the D-alanine--D-alanine ligase family
OFO16_RS16795	COG0023	Translation Initiation Factor
OFO16_RS16800	COG2801	Transposase and inactivated derivatives
OFO16_RS16820	COG3293	Transposase
OFO16_RS16825	COG3140	Belongs to the UPF0181 family
OFO16_RS16840	COG0745	RESPONSE REGULATOR receiver
OFO16_RS16850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
OFO16_RS16855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
OFO16_RS16870	COG3706	GGDEF domain
OFO16_RS16875	COG5001	Diguanylate cyclase
OFO16_RS16875	COG2203	Gaf domain
OFO16_RS16875	COG3706	GGDEF domain
OFO16_RS16875	COG4251	negative regulation of phosphorylation
OFO16_RS16880	COG3335	DDE superfamily endonuclease
OFO16_RS16890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OFO16_RS16895	COG4149	molybdate abc transporter
OFO16_RS16900	COG0725	ABC transporter, periplasmic molybdate-binding protein
OFO16_RS16905	COG1492	cobalamin metabolic process
OFO16_RS16915	COG0189	ligase activity
OFO16_RS16915	COG4067	protein conserved in archaea
OFO16_RS16925	COG2207	Transcriptional regulator
OFO16_RS16930	COG0534	Mate efflux family protein
OFO16_RS16935	COG0602	queuosine metabolic process
OFO16_RS16940	COG1328	CTP reductase activity
OFO16_RS16990	COG0583	DNA-binding transcription factor activity
OFO16_RS16995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OFO16_RS17015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OFO16_RS17020	COG3118	belongs to the thioredoxin family
OFO16_RS17030	COG3385	transposase activity
OFO16_RS17050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OFO16_RS17070	COG2116	formate transmembrane transporter activity
OFO16_RS17080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OFO16_RS17085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFO16_RS17090	COG5001	Diguanylate cyclase
OFO16_RS17115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OFO16_RS17115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFO16_RS17165	COG0277	FAD linked oxidase domain protein
OFO16_RS17170	COG0583	DNA-binding transcription factor activity
OFO16_RS17180	COG2425	protein containing a von Willebrand factor type A (vWA) domain
OFO16_RS17195	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
OFO16_RS17210	COG3040	lipid binding
OFO16_RS17220	COG0702	epimerase
OFO16_RS17225	COG1733	regulation of RNA biosynthetic process
OFO16_RS17245	COG0419	ATPase involved in DNA repair
OFO16_RS17250	COG0420	3'-5' exonuclease activity
OFO16_RS17255	COG2130	NADP-dependent
OFO16_RS17260	COG1846	Transcriptional regulator
OFO16_RS17270	COG0745	RESPONSE REGULATOR receiver
OFO16_RS17275	COG2205	protein histidine kinase activity
OFO16_RS17305	COG3335	DDE superfamily endonuclease
OFO16_RS17310	COG3335	DDE superfamily endonuclease
OFO16_RS17315	COG4172	Belongs to the ABC transporter superfamily
OFO16_RS17320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_RS17325	COG0601	transmembrane transport
OFO16_RS17330	COG4166	transmembrane transport
OFO16_RS17345	COG0765	amino acid transport
OFO16_RS17350	COG0765	amino acid transport
OFO16_RS17360	COG1737	Transcriptional regulator
OFO16_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS17370	COG4670	ketone body catabolic process
OFO16_RS17390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OFO16_RS17425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
OFO16_RS17430	COG0069	glutamate synthase activity
OFO16_RS17445	COG3290	protein histidine kinase activity
OFO16_RS17455	COG0471	metal ion transport
OFO16_RS17460	COG3385	transposase activity
OFO16_RS17510	COG0589	response to stress
OFO16_RS17525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OFO16_RS17530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OFO16_RS17530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OFO16_RS17545	COG0356	it plays a direct role in the translocation of protons across the membrane
OFO16_RS17560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OFO16_RS17565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OFO16_RS17575	COG1214	PFAM Peptidase M22, glycoprotease
OFO16_RS17575	COG0456	acetyltransferase
OFO16_RS17590	COG3069	C4-dicarboxylate transmembrane transporter activity
OFO16_RS17595	COG1704	LemA family
OFO16_RS17600	COG0501	Belongs to the peptidase M48B family
OFO16_RS17610	COG2223	nitrite transmembrane transporter activity
OFO16_RS17620	COG1597	lipid kinase activity
OFO16_RS17650	COG0583	DNA-binding transcription factor activity
OFO16_RS17665	COG0784	Response regulator, receiver
OFO16_RS17665	COG2205	protein histidine kinase activity
OFO16_RS17665	COG2198	Histidine kinase
OFO16_RS17670	COG1879	ABC-type sugar transport system periplasmic component
OFO16_RS17675	COG1803	Methylglyoxal synthase
OFO16_RS17680	COG0210	DNA helicase
OFO16_RS17685	COG1289	transmembrane transporter activity
OFO16_RS17700	COG0789	Transcriptional regulator
OFO16_RS17705	COG1609	Transcriptional regulator
OFO16_RS17710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_RS17715	COG1879	ABC-type sugar transport system periplasmic component
OFO16_RS17720	COG1172	Belongs to the binding-protein-dependent transport system permease family
OFO16_RS17725	COG1129	ABC transporter
OFO16_RS17730	COG1869	D-ribose catabolic process
OFO16_RS17735	COG5001	Diguanylate cyclase
OFO16_RS17785	COG0583	DNA-binding transcription factor activity
OFO16_RS17790	COG5002	protein histidine kinase activity
OFO16_RS17795	COG0745	RESPONSE REGULATOR receiver
OFO16_RS17810	COG2916	Histone family protein nucleoid-structuring protein H-NS
OFO16_RS17835	COG2205	protein histidine kinase activity
OFO16_RS17850	COG0582	viral genome integration into host DNA
OFO16_RS17890	COG1278	Cold shock
OFO16_RS17895	COG4628	conserved protein (DUF2132)
OFO16_RS17905	COG3335	DDE superfamily endonuclease
OFO16_RS17915	COG1280	lysine exporter protein (LysE YggA)
OFO16_RS17920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OFO16_RS17935	COG3265	gluconokinase activity
OFO16_RS18065	COG0243	molybdopterin cofactor binding
OFO16_RS18070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OFO16_RS18070	COG1648	precorrin-2 dehydrogenase activity
OFO16_RS18075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OFO16_RS18085	COG2223	nitrite transmembrane transporter activity
OFO16_RS18090	COG0515	serine threonine protein kinase
OFO16_RS18090	COG2815	serine threonine protein kinase
OFO16_RS18095	COG2197	response regulator
OFO16_RS18100	COG2207	Transcriptional regulator
OFO16_RS18145	COG0330	HflC and HflK could
OFO16_RS18150	COG0517	IMP dehydrogenase activity
OFO16_RS18150	COG4175	Glycine betaine
OFO16_RS18155	COG4176	ABC-type proline glycine betaine transport system permease component
OFO16_RS18170	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS18175	COG1309	transcriptional regulator
OFO16_RS18180	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS18195	COG1024	Enoyl-CoA hydratase
OFO16_RS18200	COG1960	acyl-CoA dehydrogenase activity
OFO16_RS18210	COG0183	Belongs to the thiolase family
OFO16_RS18220	COG1960	acyl-CoA dehydrogenase activity
OFO16_RS18225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OFO16_RS18230	COG1024	Enoyl-CoA hydratase
OFO16_RS18235	COG4770	biotin carboxylase activity
OFO16_RS18270	COG4948	Mandelate Racemase Muconate Lactonizing
OFO16_RS18295	COG0583	DNA-binding transcription factor activity
OFO16_RS18305	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
OFO16_RS18305	COG3264	Mechanosensitive ion channel
OFO16_RS18315	COG3474	cytochrome
OFO16_RS18320	COG3293	Transposase
OFO16_RS18385	COG2205	protein histidine kinase activity
OFO16_RS18385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS18420	COG2814	Major facilitator Superfamily
OFO16_RS18430	COG0840	transmembrane signaling receptor activity
OFO16_RS18440	COG2814	Major facilitator Superfamily
OFO16_RS18450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OFO16_RS18465	COG1355	regulation of microtubule-based process
OFO16_RS18490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OFO16_RS18490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OFO16_RS18495	COG2610	gluconate transmembrane transporter activity
OFO16_RS18500	COG3622	Belongs to the hyi family
OFO16_RS18505	COG0235	Class ii aldolase
OFO16_RS18510	COG3395	kinase activity
OFO16_RS18515	COG2084	Dehydrogenase
OFO16_RS18520	COG1349	DNA-binding transcription factor activity
OFO16_RS18525	COG0656	L-ascorbic acid biosynthetic process
OFO16_RS18530	COG0402	S-adenosylhomocysteine deaminase activity
OFO16_RS18560	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS18595	COG0667	Aldo Keto reductase
OFO16_RS18600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OFO16_RS18610	COG0583	DNA-binding transcription factor activity
OFO16_RS18630	COG0579	oxidoreductase
OFO16_RS18645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OFO16_RS18655	COG4771	TonB-dependent receptor
OFO16_RS18665	COG0583	DNA-binding transcription factor activity
OFO16_RS18670	COG2814	Major facilitator Superfamily
OFO16_RS18675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_RS18715	COG1757	Na H antiporter
OFO16_RS18760	COG3706	GGDEF domain
OFO16_RS18785	COG3850	Histidine kinase
OFO16_RS18785	COG3437	response regulator, receiver
OFO16_RS18785	COG2205	protein histidine kinase activity
OFO16_RS18785	COG4999	Histidine kinase
OFO16_RS18810	COG0582	viral genome integration into host DNA
OFO16_RS18815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OFO16_RS18850	COG3293	Transposase
OFO16_RS18875	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
OFO16_RS18880	COG2731	YhcH YjgK YiaL family protein
OFO16_RS18885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OFO16_RS18895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_RS18900	COG1414	Transcriptional regulator
OFO16_RS18905	COG0800	Aldolase
OFO16_RS18910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_RS18915	COG1917	Cupin 2, conserved barrel domain protein
OFO16_RS18955	COG0246	Mannitol dehydrogenase
OFO16_RS18965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_RS18970	COG2186	Transcriptional regulator
OFO16_RS18980	COG3181	Tripartite tricarboxylate transporter family receptor
OFO16_RS19040	COG2186	Transcriptional regulator
OFO16_RS19045	COG2186	Transcriptional regulator
OFO16_RS19050	COG0517	IMP dehydrogenase activity
OFO16_RS19055	COG2176	DNA-directed DNA polymerase activity
OFO16_RS19060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_RS19085	COG0516	GMP reductase activity
OFO16_RS19090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OFO16_RS19090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OFO16_RS19095	COG4989	oxidoreductase activity
OFO16_RS19110	COG0038	chloride channel
OFO16_RS19130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OFO16_RS19140	COG2897	thiosulfate sulfurtransferase activity
OFO16_RS19150	COG2358	TRAP transporter, solute receptor (TAXI family
OFO16_RS19160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OFO16_RS19165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OFO16_RS19170	COG0840	transmembrane signaling receptor activity
OFO16_RS19175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFO16_RS19185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_RS19195	COG0840	transmembrane signaling receptor activity
OFO16_RS19215	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFO16_RS19230	COG2197	response regulator
OFO16_RS19235	COG3850	Histidine kinase
OFO16_RS19240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OFO16_RS19240	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
OFO16_RS19250	COG0243	molybdopterin cofactor binding
OFO16_RS19260	COG3005	denitrification pathway
OFO16_RS19280	COG0183	Belongs to the thiolase family
OFO16_RS19290	COG1280	lysine exporter protein (LysE YggA)
OFO16_RS19295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFO16_RS19300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFO16_RS19350	COG0784	Response regulator, receiver
OFO16_RS19350	COG2205	protein histidine kinase activity
OFO16_RS19355	COG1879	ABC-type sugar transport system periplasmic component
OFO16_RS19365	COG3132	Protein of unknown function, DUF480
OFO16_RS19385	COG0673	inositol 2-dehydrogenase activity
OFO16_RS19410	COG1522	sequence-specific DNA binding
OFO16_RS19415	COG0531	amino acid
OFO16_RS19430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OFO16_RS19435	COG2239	Acts as a magnesium transporter
OFO16_RS19440	COG1418	mRNA catabolic process
OFO16_RS19460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OFO16_RS19465	COG3385	transposase activity
OFO16_RS19480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFO16_RS19495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OFO16_RS19500	COG2194	sulfuric ester hydrolase activity
OFO16_RS19505	COG0673	inositol 2-dehydrogenase activity
OFO16_RS19510	COG3304	Inner membrane component domain
OFO16_RS19525	COG4667	esterase of the alpha-beta hydrolase superfamily
OFO16_RS19530	COG1741	Belongs to the pirin family
OFO16_RS19535	COG1278	Cold shock
OFO16_RS19550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OFO16_RS19570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OFO16_RS19590	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
OFO16_RS19650	COG0625	glutathione transferase activity
OFO16_RS19660	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS19695	COG0513	Belongs to the DEAD box helicase family
OFO16_RS19705	COG0583	DNA-binding transcription factor activity
OFO16_RS19720	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS19730	COG2723	6-phospho-beta-galactosidase activity
OFO16_RS19735	COG1263	PTS System
OFO16_RS19735	COG2190	(PTS) system
OFO16_RS19735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_RS19740	COG2723	6-phospho-beta-galactosidase activity
OFO16_RS19745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_RS19750	COG1609	Transcriptional regulator
OFO16_RS19755	COG0006	proline dipeptidase activity
OFO16_RS19760	COG3608	succinylglutamate desuccinylase aspartoacylase
OFO16_RS19765	COG1522	sequence-specific DNA binding
OFO16_RS19770	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS19775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFO16_RS19780	COG3122	Protein conserved in bacteria
OFO16_RS19785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OFO16_RS19790	COG2986	histidine ammonia-lyase
OFO16_RS19820	COG1309	transcriptional regulator
OFO16_RS19855	COG2233	PERMEase
OFO16_RS19865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_RS19885	COG1278	Cold shock
OFO16_RS19890	COG0557	exoribonuclease II activity
OFO16_RS19905	COG2188	Transcriptional regulator
OFO16_RS19915	COG0697	spore germination
OFO16_RS19925	COG0583	DNA-binding transcription factor activity
OFO16_RS19930	COG2814	Major facilitator Superfamily
OFO16_RS19935	COG4566	intracellular signal transduction
OFO16_RS19940	COG4191	Histidine kinase
OFO16_RS19945	COG0318	PFAM AMP-dependent synthetase and ligase
OFO16_RS19950	COG0659	secondary active sulfate transmembrane transporter activity
OFO16_RS19955	COG0583	DNA-binding transcription factor activity
OFO16_RS19960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OFO16_RS19965	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OFO16_RS19970	COG0574	Belongs to the PEP-utilizing enzyme family
OFO16_RS19970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OFO16_RS19985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OFO16_RS19990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFO16_RS20005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_RS20020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_RS20050	COG3842	ATPase activity
OFO16_RS20080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OFO16_RS20135	COG1342	Belongs to the UPF0251 family
OFO16_RS20140	COG3015	lipoprotein NlpE involved in copper resistance
OFO16_RS20145	COG0583	DNA-binding transcription factor activity
OFO16_RS20150	COG0697	spore germination
OFO16_RS20165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OFO16_RS20175	COG1335	isochorismatase
OFO16_RS20190	COG0531	amino acid
OFO16_RS20195	COG4302	ethanolamine ammonia-lyase activity
OFO16_RS20200	COG4303	Ethanolamine ammonia lyase large subunit
OFO16_RS20210	COG1309	transcriptional regulator
OFO16_RS20230	COG1280	lysine exporter protein (LysE YggA)
OFO16_RS20235	COG0459	protein refolding
OFO16_RS20240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OFO16_RS20245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFO16_RS20270	COG1304	FMN binding
OFO16_RS20285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OFO16_RS20305	COG1760	l-serine dehydratase
OFO16_RS20310	COG0583	DNA-binding transcription factor activity
OFO16_RS20320	COG2866	Carboxypeptidase
OFO16_RS20325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_RS20345	COG3842	ATPase activity
OFO16_RS20355	COG3385	transposase activity
OFO16_RS20360	COG1840	ABC-type Fe3 transport system, periplasmic component
OFO16_RS20370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_RS20390	COG3240	lipase activity
OFO16_RS20400	COG0577	efflux transmembrane transporter activity
OFO16_RS20400	COG1136	(ABC) transporter
OFO16_RS20405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_RS20420	COG1011	Hydrolase
OFO16_RS20430	COG3152	Membrane
OFO16_RS20440	COG1765	OsmC-like protein
OFO16_RS20445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFO16_RS20445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFO16_RS20460	COG3046	protein related to deoxyribodipyrimidine photolyase
OFO16_RS20465	COG3706	GGDEF domain
OFO16_RS20505	COG3385	transposase activity
OFO16_RS20510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFO16_RS20525	COG0579	oxidoreductase
OFO16_RS20540	COG3706	GGDEF domain
OFO16_RS20560	COG0189	ligase activity
OFO16_RS20565	COG4067	protein conserved in archaea
OFO16_RS20565	COG0189	ligase activity
OFO16_RS20575	COG1166	arginine decarboxylase activity
OFO16_RS20580	COG0010	Belongs to the arginase family
OFO16_RS20585	COG3293	Transposase
OFO16_RS20590	COG2814	Major facilitator Superfamily
OFO16_RS20595	COG1770	oligopeptidase
OFO16_RS20615	COG0848	biopolymer transport protein
OFO16_RS20620	COG0811	peptide transport
OFO16_RS20625	COG0811	peptide transport
OFO16_RS20640	COG2205	protein histidine kinase activity
OFO16_RS20645	COG0745	RESPONSE REGULATOR receiver
OFO16_RS20650	COG0039	L-malate dehydrogenase activity
OFO16_RS20655	COG0584	glycerophosphoryl diester phosphodiesterase
OFO16_RS20665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OFO16_RS20730	COG1901	pseudouridine methyltransferase
OFO16_RS20735	COG0312	modulator of DNA gyrase
OFO16_RS20740	COG0312	modulator of DNA gyrase
OFO16_RS20745	COG0351	phosphomethylpyrimidine kinase
OFO16_RS20750	COG1116	anion transmembrane transporter activity
OFO16_RS20755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OFO16_RS20760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OFO16_RS20765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OFO16_RS20785	COG0243	molybdopterin cofactor binding
OFO16_RS20790	COG3005	denitrification pathway
OFO16_RS20805	COG1929	Belongs to the glycerate kinase type-1 family
OFO16_RS20815	COG3835	regulator
OFO16_RS20855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OFO16_RS20870	COG3047	cAMP biosynthetic process
OFO16_RS20895	COG2375	cellular response to nickel ion
OFO16_RS20900	COG0800	Aldolase
OFO16_RS20905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_RS20920	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_RS20930	COG0583	DNA-binding transcription factor activity
OFO16_RS20945	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OFO16_RS20965	COG0561	phosphatase activity
OFO16_RS20970	COG0583	DNA-binding transcription factor activity
OFO16_RS20980	COG0564	pseudouridine synthase activity
OFO16_RS20985	COG0534	Mate efflux family protein
OFO16_RS20990	COG5001	Diguanylate cyclase
OFO16_RS21000	COG3123	guanosine phosphorylase activity
OFO16_RS21035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OFO16_RS21040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OFO16_RS21045	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OFO16_RS21055	COG2259	Doxx family
OFO16_RS21060	COG1741	Belongs to the pirin family
OFO16_RS21080	COG0363	glucosamine-6-phosphate deaminase activity
OFO16_RS21105	COG1131	(ABC) transporter
OFO16_RS21115	COG0786	glutamate:sodium symporter activity
OFO16_RS21125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OFO16_RS21130	COG3279	Response regulator of the LytR AlgR family
OFO16_RS21135	COG3275	phosphorelay sensor kinase activity
OFO16_RS21150	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFO16_RS21155	COG1136	(ABC) transporter
OFO16_RS21205	COG1444	tRNA N-acetyltransferase activity
OFO16_RS21260	COG0259	pyridoxamine-phosphate oxidase activity
OFO16_RS21285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_RS21305	COG3293	Transposase
OFO16_RS21320	COG3119	arylsulfatase activity
OFO16_RS21325	COG3119	arylsulfatase activity
OFO16_RS21330	COG3634	alkyl hydroperoxide reductase activity
OFO16_RS21340	COG1846	Transcriptional regulator
OFO16_RS21345	COG1764	response to oxidative stress
OFO16_RS21360	COG0577	efflux transmembrane transporter activity
OFO16_RS21365	COG1136	(ABC) transporter
OFO16_RS21370	COG4221	oxidoreductase activity
OFO16_RS21380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OFO16_RS21385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFO16_RS21390	COG4521	taurine ABC transporter
OFO16_RS21395	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OFO16_RS21400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OFO16_RS21410	COG2211	Major facilitator Superfamily
OFO16_RS21415	COG3940	Belongs to the glycosyl hydrolase 43 family
OFO16_RS21420	COG2017	converts alpha-aldose to the beta-anomer
OFO16_RS21430	COG3335	DDE superfamily endonuclease
OFO16_RS21435	COG2160	L-arabinose isomerase activity
OFO16_RS21445	COG1069	ribulokinase activity
OFO16_RS21450	COG1879	ABC-type sugar transport system periplasmic component
OFO16_RS21455	COG1129	ABC transporter
OFO16_RS21460	COG1172	Belongs to the binding-protein-dependent transport system permease family
OFO16_RS21470	COG4772	TonB-dependent receptor
OFO16_RS21475	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OFO16_RS21490	COG0642	Histidine kinase
OFO16_RS21495	COG1653	transport
OFO16_RS21500	COG3119	arylsulfatase activity
OFO16_RS21520	COG2423	ornithine cyclodeaminase activity
OFO16_RS21530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_RS21570	COG0583	DNA-binding transcription factor activity
OFO16_RS21590	COG3171	Protein conserved in bacteria
OFO16_RS21605	COG0814	amino acid
OFO16_RS21610	COG3033	Beta-eliminating lyase
OFO16_RS21640	COG4604	ABC transporter, ATP-binding protein
OFO16_RS21645	COG4605	iron ion homeostasis
OFO16_RS21650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFO16_RS21655	COG4607	ABC-type enterochelin transport system periplasmic component
OFO16_RS21660	COG0583	DNA-binding transcription factor activity
OFO16_RS21665	COG4771	TonB-dependent receptor
OFO16_RS21670	COG2814	Major facilitator Superfamily
OFO16_RS21680	COG1263	PTS System
OFO16_RS21680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_RS21710	COG0366	Alpha amylase catalytic
OFO16_RS21725	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
OFO16_RS21730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
OFO16_RS21735	COG1162	GTPase activity
OFO16_RS21740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_RS21740	COG1263	PTS System
OFO16_RS21745	COG1999	signal sequence binding
OFO16_RS21760	COG2909	trisaccharide binding
OFO16_RS21765	COG0058	SHG alpha-glucan phosphorylase activity
OFO16_RS21770	COG1640	4-alpha-glucanotransferase
OFO16_RS21775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OFO16_RS21780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OFO16_RS21785	COG0366	Alpha amylase catalytic
OFO16_RS21790	COG3339	Conserved Protein
OFO16_RS21795	COG1301	dicarboxylic acid transport
OFO16_RS21810	COG2095	MarC family integral membrane protein
OFO16_RS21815	COG4667	esterase of the alpha-beta hydrolase superfamily
OFO16_RS21820	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
OFO16_RS21825	COG1054	Belongs to the UPF0176 family
OFO16_RS21840	COG1686	Belongs to the peptidase S11 family
OFO16_RS21845	COG4628	conserved protein (DUF2132)
OFO16_RS21855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFO16_RS21860	COG3385	transposase activity
OFO16_RS21865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OFO16_RS21900	COG3293	Transposase
OFO16_RS21935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OFO16_RS21980	COG0745	RESPONSE REGULATOR receiver
OFO16_RS22005	COG3300	MHYT domain
OFO16_RS22005	COG5001	Diguanylate cyclase
OFO16_RS22010	COG0156	8-amino-7-oxononanoate synthase activity
OFO16_RS22015	COG1063	alcohol dehydrogenase
OFO16_RS22025	COG1278	Cold shock
OFO16_RS22040	COG0668	transmembrane transport
OFO16_RS22050	COG1304	FMN binding
OFO16_RS22055	COG1620	l-lactate permease
OFO16_RS22060	COG0583	DNA-binding transcription factor activity
OFO16_RS22065	COG1505	serine-type exopeptidase activity
OFO16_RS22075	COG1067	ATP-dependent peptidase activity
OFO16_RS22095	COG1247	-acetyltransferase
OFO16_RS22100	COG0437	4 iron, 4 sulfur cluster binding
OFO16_RS22105	COG0348	domain, Protein
OFO16_RS22115	COG4720	Psort location CytoplasmicMembrane, score
OFO16_RS22120	COG1566	PFAM secretion protein HlyD family protein
OFO16_RS22130	COG3706	GGDEF domain
OFO16_RS22145	COG0813	purine-nucleoside phosphorylase activity
OFO16_RS22150	COG3272	Protein of unknown function (DUF1722)
OFO16_RS22155	COG0789	Transcriptional regulator
OFO16_RS22160	COG0415	Belongs to the DNA photolyase family
OFO16_RS22165	COG1376	ErfK ybiS ycfS ynhG family protein
OFO16_RS22165	COG1388	LysM domain
OFO16_RS22175	COG0513	Belongs to the DEAD box helicase family
OFO16_RS22190	COG0573	inorganic phosphate transmembrane transporter activity
OFO16_RS22195	COG0581	inorganic phosphate transmembrane transporter activity
OFO16_RS22200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OFO16_RS22210	COG2304	oxidoreductase activity
OFO16_RS22230	COG0714	Associated with various cellular activities
OFO16_RS22240	COG3385	transposase activity
OFO16_RS22285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_RS22300	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OFO16_RS22305	COG1120	ATPase activity
OFO16_RS22310	COG4774	siderophore transport
OFO16_RS22315	COG1132	(ABC) transporter
OFO16_RS22320	COG0583	DNA-binding transcription factor activity
OFO16_RS22335	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS22350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_RS22360	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
OFO16_RS22365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_RS22370	COG2084	Dehydrogenase
OFO16_RS22380	COG2130	NADP-dependent
OFO16_RS22385	COG1309	transcriptional regulator
OFO16_RS22390	COG3097	Belongs to the UPF0267 family
OFO16_RS22420	COG0438	transferase activity, transferring glycosyl groups
OFO16_RS22445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OFO16_RS22450	COG3842	ATPase activity
OFO16_RS22460	COG1175	transmembrane transport
OFO16_RS22465	COG3833	ABC-type maltose transport systems, permease component
OFO16_RS22505	COG3344	reverse transcriptase
OFO16_RS22540	COG3344	reverse transcriptase
OFO16_RS22550	COG3344	reverse transcriptase
OFO16_RS22555	COG4999	Histidine kinase
OFO16_RS22555	COG3850	Histidine kinase
OFO16_RS22555	COG3437	response regulator, receiver
OFO16_RS22555	COG2205	protein histidine kinase activity
OFO16_RS22575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_RS22610	COG0741	lytic transglycosylase activity
OFO16_RS22620	COG1522	sequence-specific DNA binding
OFO16_RS22630	COG1448	Aminotransferase
OFO16_RS22640	COG3385	transposase activity
OFO16_RS22665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OFO16_RS22670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OFO16_RS22675	COG1984	allophanate hydrolase subunit 2
OFO16_RS22695	COG0071	Belongs to the small heat shock protein (HSP20) family
OFO16_RS22720	COG1609	Transcriptional regulator
OFO16_RS22735	COG0395	ABC-type sugar transport system, permease component
OFO16_RS22740	COG2723	6-phospho-beta-galactosidase activity
OFO16_RS22745	COG3842	ATPase activity
OFO16_RS22750	COG1609	Transcriptional regulator
OFO16_RS22760	COG0747	negative chemotaxis
OFO16_RS22770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_RS22775	COG0444	Belongs to the ABC transporter superfamily
OFO16_RS22780	COG4608	Belongs to the ABC transporter superfamily
OFO16_RS22790	COG1609	Transcriptional regulator
OFO16_RS22810	COG1472	Belongs to the glycosyl hydrolase 3 family
OFO16_RS22835	COG2176	DNA-directed DNA polymerase activity
OFO16_RS22845	COG2354	Protein conserved in bacteria
OFO16_RS22850	COG0418	dihydroorotase activity
OFO16_RS22860	COG3217	Mosc domain protein beta barrel domain protein
OFO16_RS22860	COG0633	Ferredoxin
OFO16_RS22860	COG3217	Mosc domain protein beta barrel domain protein
OFO16_RS22860	COG0633	Ferredoxin
OFO16_RS22865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OFO16_RS22870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OFO16_RS22905	COG0748	coenzyme F420 binding
OFO16_RS22910	COG0835	chemotaxis
OFO16_RS22910	COG0784	Response regulator, receiver
OFO16_RS22915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFO16_RS22935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OFO16_RS22950	COG1063	alcohol dehydrogenase
OFO16_RS22955	COG0583	DNA-binding transcription factor activity
OFO16_RS22970	COG1902	pentaerythritol trinitrate reductase activity
OFO16_RS22985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OFO16_RS22990	COG4948	Mandelate Racemase Muconate Lactonizing
OFO16_RS23000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OFO16_RS23025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OFO16_RS23035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFO16_RS23045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_RS23055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OFO16_RS23065	COG1979	alcohol dehydrogenase
OFO16_RS23070	COG0366	Alpha amylase catalytic
OFO16_RS23085	COG1472	Belongs to the glycosyl hydrolase 3 family
OFO16_RS23100	COG2249	NAD(P)H dehydrogenase (quinone) activity
OFO16_RS23105	COG0589	response to stress
OFO16_RS23110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFO16_RS23130	COG2871	sodium ion transport
OFO16_RS23140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_RS23160	COG3383	formate dehydrogenase (NAD+) activity
OFO16_RS23170	COG0842	Transport permease protein
OFO16_RS23175	COG1131	(ABC) transporter
OFO16_RS23190	COG0798	PFAM Bile acid sodium symporter
OFO16_RS23225	COG0814	amino acid
OFO16_RS23245	COG3314	Sporulation integral membrane protein YlbJ
OFO16_RS23265	COG0739	heme binding
OFO16_RS23270	COG5001	Diguanylate cyclase
OFO16_RS23275	COG0583	DNA-binding transcription factor activity
OFO16_RS23300	COG0179	Fumarylacetoacetate (FAA) hydrolase
OFO16_RS23320	COG1280	lysine exporter protein (LysE YggA)
OFO16_RS23325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OFO16_RS23340	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
OFO16_RS23345	COG1845	cytochrome c oxidase, subunit III
OFO16_RS23370	COG0109	protoheme IX farnesyltransferase activity
OFO16_RS23375	COG0545	Peptidyl-prolyl cis-trans isomerase
OFO16_RS23405	COG1278	Cold shock
OFO16_RS23435	COG0577	efflux transmembrane transporter activity
OFO16_RS23435	COG1136	(ABC) transporter
OFO16_RS23450	COG0783	Belongs to the Dps family
OFO16_RS23460	COG2133	pyrroloquinoline quinone binding
OFO16_RS23465	COG1454	alcohol dehydrogenase
OFO16_RS23470	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
OFO16_RS23490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OFO16_RS23495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OFO16_RS23500	COG3186	Phenylalanine-4-hydroxylase
OFO16_RS23525	COG3530	Putative quorum-sensing-regulated virulence factor
OFO16_RS23535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFO16_RS23560	COG0789	Transcriptional regulator
OFO16_RS23565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OFO16_RS23570	COG0133	tryptophan synthase activity
OFO16_RS23580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
OFO16_RS23585	COG0523	cobalamin synthesis protein
OFO16_RS23590	COG0513	Belongs to the DEAD box helicase family
OFO16_RS23605	COG2200	EAL domain
OFO16_RS23610	COG1119	ATPase activity
OFO16_RS23635	COG0446	pyridine nucleotide-disulphide oxidoreductase
OFO16_RS23635	COG1902	pentaerythritol trinitrate reductase activity
OFO16_RS23640	COG2181	nitrate reductase activity
OFO16_RS23640	COG0247	lactate metabolic process
OFO16_RS23645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OFO16_RS23655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_RS23665	COG0656	L-ascorbic acid biosynthetic process
OFO16_RS23675	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_RS23680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFO16_RS23700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_RS23710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFO16_RS23715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OFO16_RS23730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OFO16_RS23730	COG0446	pyridine nucleotide-disulphide oxidoreductase
OFO16_RS23745	COG1760	l-serine dehydratase
OFO16_RS23760	COG1064	alcohol dehydrogenase
OFO16_RS23765	COG1979	alcohol dehydrogenase
OFO16_RS23770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OFO16_RS23775	COG1085	galactose-1-phosphate uridylyltransferase
OFO16_RS23785	COG3385	transposase activity
OFO16_RS23830	COG1070	Carbohydrate kinase
OFO16_RS23840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_RS23860	COG2855	membrane
OFO16_RS23875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_RS23880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFO16_RS23885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OFO16_RS23890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OFO16_RS23890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OFO16_RS23900	COG1414	Transcriptional regulator
OFO16_RS23905	COG0280	phosphate acetyltransferase
OFO16_RS23910	COG0730	response to heat
OFO16_RS23935	COG0644	oxidoreductase
OFO16_RS23970	COG1953	Uracil, thiamine, allantoin
OFO16_RS23975	COG0590	tRNA wobble adenosine to inosine editing
OFO16_RS23990	COG3335	DDE superfamily endonuclease
OFO16_RS24010	COG0583	DNA-binding transcription factor activity
OFO16_RS24015	COG2807	transmembrane transport
OFO16_RS24030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OFO16_RS24035	COG1304	FMN binding
OFO16_RS24040	COG0549	Belongs to the carbamate kinase family
OFO16_RS24090	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
OFO16_RS24095	COG0589	response to stress