locus-tag	class	description
EWA66_RS00025	COG2840	Smr protein MutS2
EWA66_RS00035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EWA66_RS00045	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EWA66_RS00050	COG2912	Transglutaminase-like superfamily
EWA66_RS00060	COG2890	protein-(glutamine-N5) methyltransferase activity
EWA66_RS00065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EWA66_RS00075	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EWA66_RS00080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EWA66_RS00085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EWA66_RS00090	COG0193	aminoacyl-tRNA hydrolase activity
EWA66_RS00185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWA66_RS00190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EWA66_RS00195	COG1702	phosphate starvation-inducible protein PhoH
EWA66_RS00200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EWA66_RS00205	COG4535	Mg2 and Co2 transporter CorC
EWA66_RS00215	COG2888	peptidyl-tyrosine sulfation
EWA66_RS00225	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EWA66_RS00230	COG1466	dna polymerase III delta subunit
EWA66_RS00235	COG0799	negative regulation of ribosome biogenesis
EWA66_RS00240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EWA66_RS00245	COG0768	penicillin binding
EWA66_RS00250	COG0772	Belongs to the SEDS family
EWA66_RS00255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EWA66_RS00260	COG1686	Belongs to the peptidase S11 family
EWA66_RS00265	COG2921	Belongs to the UPF0250 family
EWA66_RS00270	COG0321	lipoyl(octanoyl) transferase activity
EWA66_RS00275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EWA66_RS00285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EWA66_RS00310	COG0366	Alpha amylase catalytic
EWA66_RS00315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA66_RS00315	COG1263	PTS System
EWA66_RS00320	COG1609	Transcriptional regulator
EWA66_RS00325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EWA66_RS00330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EWA66_RS00335	COG2011	ABC-type metal ion transport system permease component
EWA66_RS00340	COG1464	Belongs to the NlpA lipoprotein family
EWA66_RS00345	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EWA66_RS00355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EWA66_RS00355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EWA66_RS00370	COG1611	Belongs to the LOG family
EWA66_RS00375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWA66_RS00390	COG2363	Small membrane protein
EWA66_RS00400	COG0583	DNA-binding transcription factor activity
EWA66_RS00405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EWA66_RS00405	COG0301	tRNA thio-modification
EWA66_RS00415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EWA66_RS00420	COG1722	exodeoxyribonuclease VII activity
EWA66_RS00425	COG0142	geranyltranstransferase activity
EWA66_RS00430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EWA66_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EWA66_RS00445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EWA66_RS00450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EWA66_RS00465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EWA66_RS00465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EWA66_RS00470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EWA66_RS00475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EWA66_RS00480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EWA66_RS00490	COG1073	alpha beta
EWA66_RS00495	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EWA66_RS00500	COG2252	PERMEase
EWA66_RS00505	COG2195	Cleaves the N-terminal amino acid of tripeptides
EWA66_RS00530	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EWA66_RS00540	COG0590	tRNA wobble adenosine to inosine editing
EWA66_RS00545	COG0583	DNA-binding transcription factor activity
EWA66_RS00550	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EWA66_RS00560	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EWA66_RS00590	COG0484	heat shock protein binding
EWA66_RS00595	COG0443	Heat shock 70 kDa protein
EWA66_RS00605	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EWA66_RS00625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EWA66_RS00635	COG0497	DNA recombination
EWA66_RS00640	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWA66_RS00645	COG2914	Belongs to the UPF0125 (RnfH) family
EWA66_RS00650	COG2867	negative regulation of translational initiation
EWA66_RS00655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EWA66_RS00670	COG0697	spore germination
EWA66_RS00685	COG0009	L-threonylcarbamoyladenylate synthase
EWA66_RS00705	COG0583	DNA-binding transcription factor activity
EWA66_RS00715	COG1115	amino acid carrier protein
EWA66_RS00720	COG1584	GPR1 FUN34 yaaH family protein
EWA66_RS00730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EWA66_RS00730	COG0519	Catalyzes the synthesis of GMP from XMP
EWA66_RS00735	COG0516	GMP reductase activity
EWA66_RS00735	COG0517	IMP dehydrogenase activity
EWA66_RS00750	COG2199	diguanylate cyclase activity
EWA66_RS00750	COG2203	Gaf domain
EWA66_RS00755	COG1160	GTP binding
EWA66_RS00760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWA66_RS00765	COG2976	Protein conserved in bacteria
EWA66_RS00770	COG0124	histidyl-tRNA synthetase
EWA66_RS00775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EWA66_RS00780	COG1426	Protein conserved in bacteria
EWA66_RS00790	COG0105	UTP biosynthetic process
EWA66_RS00795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EWA66_RS00800	COG2975	iron-sulfur cluster assembly
EWA66_RS00805	COG0633	Ferredoxin
EWA66_RS00810	COG0443	Heat shock 70 kDa protein
EWA66_RS00815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EWA66_RS00820	COG0316	Belongs to the HesB IscA family
EWA66_RS00825	COG0822	iron-sulfur transferase activity
EWA66_RS00830	COG1104	cysteine desulfurase activity
EWA66_RS00835	COG1959	2 iron, 2 sulfur cluster binding
EWA66_RS00840	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EWA66_RS00845	COG0483	inositol monophosphate 1-phosphatase activity
EWA66_RS00850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWA66_RS00855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWA66_RS00860	COG1862	Preprotein translocase
EWA66_RS00865	COG0343	queuine tRNA-ribosyltransferase activity
EWA66_RS00870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EWA66_RS00880	COG0517	IMP dehydrogenase activity
EWA66_RS00890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EWA66_RS00895	COG0583	DNA-binding transcription factor activity
EWA66_RS00900	COG0450	alkyl hydroperoxide reductase
EWA66_RS00915	COG0704	Plays a role in the regulation of phosphate uptake
EWA66_RS00925	COG0581	inorganic phosphate transmembrane transporter activity
EWA66_RS00940	COG0248	Ppx GppA phosphatase
EWA66_RS00950	COG5002	protein histidine kinase activity
EWA66_RS00955	COG0745	RESPONSE REGULATOR receiver
EWA66_RS00965	COG0826	peptidase U32
EWA66_RS00970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EWA66_RS01025	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWA66_RS01030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EWA66_RS01035	COG0077	Prephenate dehydratase
EWA66_RS01035	COG1605	Chorismate mutase
EWA66_RS01040	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EWA66_RS01045	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EWA66_RS01055	COG0488	(ABC) transporter
EWA66_RS01065	COG0739	heme binding
EWA66_RS01070	COG0287	Prephenate dehydrogenase
EWA66_RS01070	COG1605	Chorismate mutase
EWA66_RS01080	COG1472	Belongs to the glycosyl hydrolase 3 family
EWA66_RS01085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EWA66_RS01105	COG1966	Carbon starvation protein
EWA66_RS01110	COG3275	phosphorelay sensor kinase activity
EWA66_RS01120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EWA66_RS01125	COG1047	Peptidyl-prolyl cis-trans
EWA66_RS01130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EWA66_RS01135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EWA66_RS01140	COG0196	riboflavin kinase activity
EWA66_RS01145	COG0728	peptidoglycan biosynthetic process
EWA66_RS01150	COG0268	Binds directly to 16S ribosomal RNA
EWA66_RS01155	COG0640	Transcriptional regulator
EWA66_RS01160	COG0583	DNA-binding transcription factor activity
EWA66_RS01165	COG1283	sodium-dependent phosphate transmembrane transporter activity
EWA66_RS01185	COG0730	response to heat
EWA66_RS01195	COG0494	nUDIX hydrolase
EWA66_RS01200	COG3066	DNA modification
EWA66_RS01210	COG0667	Aldo Keto reductase
EWA66_RS01220	COG2204	response regulator
EWA66_RS01225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EWA66_RS01235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EWA66_RS01240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EWA66_RS01245	COG4974	Belongs to the 'phage' integrase family
EWA66_RS01260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EWA66_RS01265	COG0513	Belongs to the DEAD box helicase family
EWA66_RS01270	COG3022	response to hydroperoxide
EWA66_RS01275	COG1115	amino acid carrier protein
EWA66_RS01290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EWA66_RS01300	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EWA66_RS01305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EWA66_RS01310	COG0083	homoserine kinase activity
EWA66_RS01325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EWA66_RS01340	COG0745	RESPONSE REGULATOR receiver
EWA66_RS01350	COG0784	Response regulator, receiver
EWA66_RS01350	COG2198	Histidine kinase
EWA66_RS01350	COG5002	protein histidine kinase activity
EWA66_RS01355	COG5001	Diguanylate cyclase
EWA66_RS01355	COG4251	negative regulation of phosphorylation
EWA66_RS01355	COG2203	Gaf domain
EWA66_RS01355	COG3706	GGDEF domain
EWA66_RS01360	COG1242	4 iron, 4 sulfur cluster binding
EWA66_RS01375	COG0067	glutamate synthase
EWA66_RS01375	COG0070	glutamate synthase
EWA66_RS01375	COG0069	glutamate synthase activity
EWA66_RS01380	COG0493	'glutamate synthase
EWA66_RS01390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EWA66_RS01395	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EWA66_RS01400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EWA66_RS01405	COG2860	membrane
EWA66_RS01410	COG0583	DNA-binding transcription factor activity
EWA66_RS01415	COG0730	response to heat
EWA66_RS01420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EWA66_RS01425	COG0505	Belongs to the CarA family
EWA66_RS01435	COG0494	nUDIX hydrolase
EWA66_RS01440	COG0653	protein targeting
EWA66_RS01445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EWA66_RS01450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EWA66_RS01455	COG0849	cell division
EWA66_RS01460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EWA66_RS01475	COG0772	Belongs to the SEDS family
EWA66_RS01485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EWA66_RS01490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EWA66_RS01500	COG0768	penicillin binding
EWA66_RS01505	COG3116	cell division
EWA66_RS01510	COG0275	rRNA processing
EWA66_RS01520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EWA66_RS01525	COG3107	peptidoglycan biosynthetic process
EWA66_RS01530	COG0792	nuclease activity
EWA66_RS01535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EWA66_RS01540	COG2823	Periplasmic or secreted lipoprotein
EWA66_RS01545	COG2969	positive regulation of protein catabolic process
EWA66_RS01550	COG0625	glutathione transferase activity
EWA66_RS01555	COG2857	Cytochrome c1
EWA66_RS01560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EWA66_RS01565	COG0723	plastoquinol--plastocyanin reductase activity
EWA66_RS01570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EWA66_RS01575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EWA66_RS01585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EWA66_RS01590	COG3105	Protein conserved in bacteria
EWA66_RS01595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWA66_RS01600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWA66_RS01615	COG3150	esterase
EWA66_RS01625	COG3151	Protein conserved in bacteria
EWA66_RS01630	COG0494	nUDIX hydrolase
EWA66_RS01635	COG1538	Outer membrane efflux protein
EWA66_RS01645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EWA66_RS01655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EWA66_RS01660	COG3025	triphosphatase activity
EWA66_RS01665	COG1392	Phosphate transport regulator
EWA66_RS01670	COG0306	phosphate transporter
EWA66_RS01675	COG4991	sh3 domain protein
EWA66_RS01680	COG3409	Peptidoglycan-binding domain 1 protein
EWA66_RS01680	COG3267	Type II secretory pathway component ExeA
EWA66_RS01685	COG0617	tRNA 3'-terminal CCA addition
EWA66_RS01690	COG1968	undecaprenyl-diphosphatase activity
EWA66_RS01695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EWA66_RS01700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EWA66_RS01715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EWA66_RS01720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EWA66_RS01725	COG1610	YqeY-like protein
EWA66_RS01730	COG0358	DNA primase activity
EWA66_RS01835	COG2378	regulation of single-species biofilm formation
EWA66_RS01905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EWA66_RS01910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA66_RS01910	COG2213	PTS system mannitol-specific
EWA66_RS01920	COG3722	fumarate hydratase activity
EWA66_RS01930	COG1349	DNA-binding transcription factor activity
EWA66_RS01940	COG1802	Transcriptional regulator
EWA66_RS01945	COG3706	GGDEF domain
EWA66_RS01950	COG0440	acetolactate synthase activity
EWA66_RS01955	COG0028	Belongs to the TPP enzyme family
EWA66_RS01960	COG1022	Amp-dependent synthetase and ligase
EWA66_RS01980	COG1309	transcriptional regulator
EWA66_RS01985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EWA66_RS01990	COG0473	3-isopropylmalate dehydrogenase activity
EWA66_RS02000	COG0066	3-isopropylmalate dehydratase activity
EWA66_RS02025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EWA66_RS02030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EWA66_RS02035	COG2967	ApaG domain
EWA66_RS02050	COG3610	response to peptide
EWA66_RS02055	COG2966	Psort location CytoplasmicMembrane, score
EWA66_RS02060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EWA66_RS02065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EWA66_RS02070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EWA66_RS02075	COG0142	geranyltranstransferase activity
EWA66_RS02085	COG0039	L-malate dehydrogenase activity
EWA66_RS02090	COG1438	arginine binding
EWA66_RS02105	COG0589	response to stress
EWA66_RS02110	COG3335	DDE superfamily endonuclease
EWA66_RS02180	COG0175	sulfate reduction
EWA66_RS02215	COG0735	belongs to the Fur family
EWA66_RS02225	COG0166	Belongs to the GPI family
EWA66_RS02240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EWA66_RS02260	COG0359	binds to the 23S rRNA
EWA66_RS02270	COG0360	Binds together with S18 to 16S ribosomal RNA
EWA66_RS02275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EWA66_RS02280	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EWA66_RS02295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EWA66_RS02325	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EWA66_RS02340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EWA66_RS02340	COG0165	Argininosuccinate lyase
EWA66_RS02345	COG0137	argininosuccinate synthase activity
EWA66_RS02355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EWA66_RS02360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EWA66_RS02365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EWA66_RS02375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EWA66_RS02380	COG0460	homoserine dehydrogenase
EWA66_RS02380	COG0527	aspartate kinase activity
EWA66_RS02385	COG0626	cystathionine gamma-synthase activity
EWA66_RS02390	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EWA66_RS02395	COG0281	malic enzyme
EWA66_RS02400	COG0254	rRNA binding
EWA66_RS02410	COG1609	Transcriptional regulator
EWA66_RS02420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EWA66_RS02425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EWA66_RS02430	COG1575	Belongs to the MenA family. Type 1 subfamily
EWA66_RS02440	COG3074	FtsZ-dependent cytokinesis
EWA66_RS02450	COG1494	fructose-1,6-bisphosphatase
EWA66_RS02470	COG2801	Transposase and inactivated derivatives
EWA66_RS02475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EWA66_RS02495	COG3023	N-Acetylmuramoyl-L-alanine amidase
EWA66_RS02505	COG5433	transposase activity
EWA66_RS02535	COG0438	transferase activity, transferring glycosyl groups
EWA66_RS02575	COG0489	protein tyrosine kinase activity
EWA66_RS02575	COG3206	protein involved in exopolysaccharide biosynthesis
EWA66_RS02580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EWA66_RS02590	COG1596	polysaccharide export
EWA66_RS02605	COG1404	Belongs to the peptidase S8 family
EWA66_RS02630	COG1560	Kdo2-lipid A biosynthetic process
EWA66_RS02635	COG0859	PFAM glycosyl transferase family 9
EWA66_RS02650	COG0110	maltose O-acetyltransferase activity
EWA66_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
EWA66_RS02660	COG1083	cytidylyl-transferase
EWA66_RS02665	COG0673	inositol 2-dehydrogenase activity
EWA66_RS02670	COG0517	IMP dehydrogenase activity
EWA66_RS02670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EWA66_RS02680	COG2089	acid synthase
EWA66_RS02685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EWA66_RS02690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EWA66_RS02710	COG0463	Glycosyl transferase, family 2
EWA66_RS02715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EWA66_RS02720	COG0673	inositol 2-dehydrogenase activity
EWA66_RS02725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EWA66_RS02745	COG3083	sulfuric ester hydrolase activity
EWA66_RS02750	COG3642	lipopolysaccharide core region biosynthetic process
EWA66_RS02755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EWA66_RS02760	COG0859	PFAM glycosyl transferase family 9
EWA66_RS02765	COG0463	Glycosyl transferase, family 2
EWA66_RS02770	COG0859	PFAM glycosyl transferase family 9
EWA66_RS02775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EWA66_RS02785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EWA66_RS02795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EWA66_RS02805	COG0149	triose-phosphate isomerase activity
EWA66_RS02825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EWA66_RS02830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EWA66_RS02835	COG2003	Belongs to the UPF0758 family
EWA66_RS02845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EWA66_RS02850	COG1309	transcriptional regulator
EWA66_RS02855	COG1560	Kdo2-lipid A biosynthetic process
EWA66_RS02865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EWA66_RS02870	COG1561	YicC-like family, N-terminal region
EWA66_RS02875	COG1120	ATPase activity
EWA66_RS02880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWA66_RS02885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWA66_RS02890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EWA66_RS02895	COG4772	TonB-dependent receptor
EWA66_RS02900	COG4774	siderophore transport
EWA66_RS02915	COG2814	Major facilitator Superfamily
EWA66_RS02920	COG4264	IucA IucC family
EWA66_RS02940	COG4608	Belongs to the ABC transporter superfamily
EWA66_RS02945	COG0444	Belongs to the ABC transporter superfamily
EWA66_RS02950	COG0747	negative chemotaxis
EWA66_RS02955	COG4239	(ABC) transporter, permease
EWA66_RS02960	COG4174	ABC transporter (Permease)
EWA66_RS02975	COG0811	peptide transport
EWA66_RS02980	COG0811	peptide transport
EWA66_RS02985	COG0848	biopolymer transport protein
EWA66_RS03000	COG0194	GDP metabolic process
EWA66_RS03005	COG1758	RNA polymerase activity
EWA66_RS03010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EWA66_RS03015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EWA66_RS03025	COG2233	PERMEase
EWA66_RS03055	COG2183	response to ionizing radiation
EWA66_RS03070	COG1040	competence protein
EWA66_RS03075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EWA66_RS03075	COG0316	Belongs to the HesB IscA family
EWA66_RS03080	COG0494	nUDIX hydrolase
EWA66_RS03085	COG1218	3'(2'),5'-bisphosphate nucleotidase
EWA66_RS03095	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EWA66_RS03100	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EWA66_RS03105	COG3156	type II secretion system protein K
EWA66_RS03110	COG4795	General secretion pathway protein
EWA66_RS03115	COG2165	general secretion pathway protein
EWA66_RS03120	COG2165	general secretion pathway protein
EWA66_RS03125	COG2165	general secretion pathway protein
EWA66_RS03130	COG1459	type II secretion system
EWA66_RS03135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EWA66_RS03145	COG3031	protein transport across the cell outer membrane
EWA66_RS03150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EWA66_RS03155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EWA66_RS03170	COG0456	acetyltransferase
EWA66_RS03175	COG1490	D-aminoacyl-tRNA deacylase activity
EWA66_RS03180	COG1295	ribonuclease BN
EWA66_RS03185	COG1217	gtp-binding protein TYPA
EWA66_RS03190	COG0174	glutamine synthetase
EWA66_RS03200	COG3852	Histidine kinase
EWA66_RS03205	COG2204	response regulator
EWA66_RS03210	COG3706	GGDEF domain
EWA66_RS03210	COG4251	negative regulation of phosphorylation
EWA66_RS03210	COG5001	Diguanylate cyclase
EWA66_RS03210	COG2203	Gaf domain
EWA66_RS03225	COG3078	GTPase activator activity
EWA66_RS03250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWA66_RS03250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWA66_RS03265	COG0084	hydrolase, TatD family'
EWA66_RS03285	COG5002	protein histidine kinase activity
EWA66_RS03285	COG5001	Diguanylate cyclase
EWA66_RS03290	COG1522	sequence-specific DNA binding
EWA66_RS03300	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EWA66_RS03305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWA66_RS03320	COG2814	Major facilitator Superfamily
EWA66_RS03325	COG0800	Aldolase
EWA66_RS03330	COG2610	gluconate transmembrane transporter activity
EWA66_RS03335	COG3265	gluconokinase activity
EWA66_RS03340	COG0129	dihydroxy-acid dehydratase activity
EWA66_RS03345	COG1609	Transcriptional regulator
EWA66_RS03360	COG0515	serine threonine protein kinase
EWA66_RS03360	COG2815	serine threonine protein kinase
EWA66_RS03395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA66_RS03400	COG0601	transmembrane transport
EWA66_RS03405	COG4166	transmembrane transport
EWA66_RS03410	COG4172	Belongs to the ABC transporter superfamily
EWA66_RS03450	COG1309	transcriptional regulator
EWA66_RS03455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWA66_RS03460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWA66_RS03465	COG2960	long-chain fatty acid transporting porin activity
EWA66_RS03470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EWA66_RS03475	COG0583	DNA-binding transcription factor activity
EWA66_RS03515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EWA66_RS03525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EWA66_RS03530	COG0408	coproporphyrinogen oxidase activity
EWA66_RS03535	COG0009	L-threonylcarbamoyladenylate synthase
EWA66_RS03540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EWA66_RS03550	COG0551	DNA topoisomerase type I activity
EWA66_RS03555	COG2922	Belongs to the Smg family
EWA66_RS03560	COG0758	DNA mediated transformation
EWA66_RS03570	COG0242	peptide deformylase activity
EWA66_RS03575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EWA66_RS03580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EWA66_RS03580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EWA66_RS03590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EWA66_RS03600	COG1272	protein, Hemolysin III
EWA66_RS03605	COG4326	sporulation control protein
EWA66_RS03610	COG3084	Protein conserved in bacteria
EWA66_RS03620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EWA66_RS03625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EWA66_RS03635	COG3005	denitrification pathway
EWA66_RS03640	COG0243	molybdopterin cofactor binding
EWA66_RS03655	COG0204	Acyl-transferase
EWA66_RS03665	COG0606	chelatase, subunit chli
EWA66_RS03675	COG3978	acetolactate synthase activity
EWA66_RS03680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EWA66_RS03695	COG0583	DNA-binding transcription factor activity
EWA66_RS03700	COG2814	Major facilitator Superfamily
EWA66_RS03710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EWA66_RS03715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EWA66_RS03720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EWA66_RS03725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EWA66_RS03730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EWA66_RS03735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EWA66_RS03745	COG0356	it plays a direct role in the translocation of protons across the membrane
EWA66_RS03750	COG3312	ion transport
EWA66_RS03755	COG1475	DNA binding
EWA66_RS03760	COG1192	Involved in chromosome partitioning
EWA66_RS03765	COG0357	Ribosomal RNA small subunit methyltransferase G
EWA66_RS03770	COG0445	tRNA wobble uridine modification
EWA66_RS03775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EWA66_RS03790	COG3730	PTS system glucitol sorbitol-specific
EWA66_RS03795	COG1349	DNA-binding transcription factor activity
EWA66_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
EWA66_RS03820	COG3730	PTS system glucitol sorbitol-specific
EWA66_RS03825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EWA66_RS03825	COG0517	IMP dehydrogenase activity
EWA66_RS03835	COG0706	membrane insertase activity
EWA66_RS03845	COG0594	ribonuclease P activity
EWA66_RS03850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EWA66_RS03855	COG1126	abc transporter atp-binding protein
EWA66_RS03875	COG0592	DNA-directed DNA polymerase activity
EWA66_RS03885	COG0187	DNA topoisomerase II activity
EWA66_RS03890	COG0071	Belongs to the small heat shock protein (HSP20) family
EWA66_RS03895	COG3977	Valine--pyruvate aminotransferase
EWA66_RS03900	COG0751	glycine-tRNA ligase activity
EWA66_RS03905	COG0752	glycyl-tRNA synthetase alpha subunit
EWA66_RS03910	COG2119	membrane
EWA66_RS03920	COG4977	sequence-specific DNA binding
EWA66_RS03950	COG0604	alcohol dehydrogenase
EWA66_RS03955	COG0183	Belongs to the thiolase family
EWA66_RS03965	COG1739	Uncharacterized protein family UPF0029
EWA66_RS03970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EWA66_RS03975	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EWA66_RS04020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EWA66_RS04025	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EWA66_RS04035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EWA66_RS04045	COG2022	thiamine diphosphate biosynthetic process
EWA66_RS04050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EWA66_RS04055	COG0006	proline dipeptidase activity
EWA66_RS04055	COG0006	proline dipeptidase activity
EWA66_RS04085	COG3220	belongs to the UPF0276 family
EWA66_RS04095	COG0210	DNA helicase
EWA66_RS04100	COG1280	lysine exporter protein (LysE YggA)
EWA66_RS04110	COG2962	Rard protein
EWA66_RS04115	COG0514	ATP-dependent DNA helicase (RecQ)
EWA66_RS04125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EWA66_RS04130	COG0248	Ppx GppA phosphatase
EWA66_RS04135	COG0513	Belongs to the DEAD box helicase family
EWA66_RS04140	COG3118	belongs to the thioredoxin family
EWA66_RS04155	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EWA66_RS04215	COG2959	enzyme of heme biosynthesis
EWA66_RS04225	COG0181	hydroxymethylbilane synthase activity
EWA66_RS04230	COG3072	Adenylate cyclase
EWA66_RS04235	COG1965	Belongs to the frataxin family
EWA66_RS04245	COG0019	diaminopimelate decarboxylase activity
EWA66_RS04250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EWA66_RS04260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EWA66_RS04265	COG1011	Hydrolase
EWA66_RS04270	COG3287	FIST C domain
EWA66_RS04270	COG2200	EAL domain
EWA66_RS04270	COG2199	diguanylate cyclase activity
EWA66_RS04275	COG3148	PFAM DTW domain containing protein
EWA66_RS04290	COG0561	phosphatase activity
EWA66_RS04295	COG2267	carboxylic ester hydrolase activity
EWA66_RS04300	COG1280	lysine exporter protein (LysE YggA)
EWA66_RS04305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EWA66_RS04310	COG3274	enterobacterial common antigen metabolic process
EWA66_RS04335	COG2095	MarC family integral membrane protein
EWA66_RS04345	COG0742	ribosomal rna small subunit methyltransferase
EWA66_RS04350	COG0552	protein localization to endoplasmic reticulum
EWA66_RS04355	COG2884	Cell division ATP-binding protein ftsE
EWA66_RS04360	COG2177	Part of the ABC transporter FtsEX involved in
EWA66_RS04375	COG0705	Rhomboid family
EWA66_RS04380	COG1580	Controls the rotational direction of flagella during chemotaxis
EWA66_RS04390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EWA66_RS04395	COG2937	Belongs to the GPAT DAPAT family
EWA66_RS04400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EWA66_RS04410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWA66_RS04425	COG0805	protein transport
EWA66_RS04430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EWA66_RS04440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EWA66_RS04450	COG2226	methyltransferase
EWA66_RS04455	COG1322	Protein conserved in bacteria
EWA66_RS04475	COG2081	HI0933 family
EWA66_RS04485	COG1528	Iron-storage protein
EWA66_RS04490	COG0589	response to stress
EWA66_RS04505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EWA66_RS04520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EWA66_RS04525	COG0724	RNA recognition motif
EWA66_RS04615	COG3335	DDE superfamily endonuclease
EWA66_RS04620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EWA66_RS04630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EWA66_RS04635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EWA66_RS04635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EWA66_RS04665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EWA66_RS04670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EWA66_RS04675	COG0250	Participates in transcription elongation, termination and antitermination
EWA66_RS04680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EWA66_RS04685	COG0081	regulation of translation
EWA66_RS04690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EWA66_RS04695	COG0222	ribosome binding
EWA66_RS04700	COG0085	RNA polymerase activity
EWA66_RS04705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EWA66_RS04720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EWA66_RS04725	COG1573	uracil-dna glycosylase
EWA66_RS04730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EWA66_RS04735	COG3068	Protein conserved in bacteria
EWA66_RS04740	COG1253	flavin adenine dinucleotide binding
EWA66_RS04760	COG0138	bifunctional purine biosynthesis protein purh
EWA66_RS04770	COG0789	Transcriptional regulator
EWA66_RS04775	COG0840	transmembrane signaling receptor activity
EWA66_RS04785	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EWA66_RS04800	COG0439	Biotin carboxylase
EWA66_RS04805	COG0511	ligase activity, forming carbon-carbon bonds
EWA66_RS04810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EWA66_RS04820	COG1902	pentaerythritol trinitrate reductase activity
EWA66_RS04825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EWA66_RS04840	COG2814	Major facilitator Superfamily
EWA66_RS04845	COG0784	Response regulator, receiver
EWA66_RS04845	COG2198	Histidine kinase
EWA66_RS04845	COG2205	protein histidine kinase activity
EWA66_RS04850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWA66_RS04860	COG3263	regulation of cellular component size
EWA66_RS04870	COG4232	protein-disulfide reductase activity
EWA66_RS04875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EWA66_RS04880	COG1027	Aspartate ammonia-lyase
EWA66_RS04890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EWA66_RS04895	COG2205	protein histidine kinase activity
EWA66_RS04900	COG0745	RESPONSE REGULATOR receiver
EWA66_RS04915	COG0205	6-phosphofructokinase activity
EWA66_RS04920	COG0534	Mate efflux family protein
EWA66_RS04925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EWA66_RS04930	COG0459	protein refolding
EWA66_RS04945	COG1509	lysine 2,3-aminomutase activity
EWA66_RS04950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EWA66_RS04965	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EWA66_RS04970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EWA66_RS04975	COG1053	succinate dehydrogenase
EWA66_RS04980	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EWA66_RS05000	COG4942	peptidase
EWA66_RS05005	COG1045	serine acetyltransferase
EWA66_RS05010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EWA66_RS05015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EWA66_RS05020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EWA66_RS05035	COG0471	metal ion transport
EWA66_RS05040	COG0688	phosphatidylethanolamine metabolic process
EWA66_RS05045	COG1162	GTPase activity
EWA66_RS05050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EWA66_RS05105	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EWA66_RS05110	COG0802	atpase or kinase
EWA66_RS05115	COG0860	N-Acetylmuramoyl-L-alanine amidase
EWA66_RS05120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EWA66_RS05135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EWA66_RS05140	COG0330	HflC and HflK could
EWA66_RS05145	COG0330	HflC and HflK could
EWA66_RS05150	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EWA66_RS05155	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EWA66_RS05160	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EWA66_RS05165	COG1017	nitric oxide dioxygenase activity
EWA66_RS05165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EWA66_RS05170	COG1959	2 iron, 2 sulfur cluster binding
EWA66_RS05175	COG0557	exoribonuclease II activity
EWA66_RS05180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EWA66_RS05190	COG0180	Tryptophanyl-tRNA synthetase
EWA66_RS05210	COG2356	endonuclease I
EWA66_RS05215	COG0446	pyridine nucleotide-disulphide oxidoreductase
EWA66_RS05225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EWA66_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
EWA66_RS05245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWA66_RS05250	COG3954	Phosphoribulokinase
EWA66_RS05255	COG3089	Belongs to the UPF0270 family
EWA66_RS05260	COG0429	hydrolase of the alpha beta-hydrolase fold
EWA66_RS05270	COG0488	(ABC) transporter
EWA66_RS05275	COG2249	NAD(P)H dehydrogenase (quinone) activity
EWA66_RS05290	COG1047	Peptidyl-prolyl cis-trans
EWA66_RS05300	COG2900	Belongs to the SlyX family
EWA66_RS05310	COG0545	Peptidyl-prolyl cis-trans isomerase
EWA66_RS05315	COG2964	Protein conserved in bacteria
EWA66_RS05320	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EWA66_RS05325	COG2923	Belongs to the DsrF TusC family
EWA66_RS05335	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EWA66_RS05340	COG0049	tRNA binding
EWA66_RS05345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EWA66_RS05355	COG2906	2 iron, 2 sulfur cluster binding
EWA66_RS05370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EWA66_RS05375	COG0088	Forms part of the polypeptide exit tunnel
EWA66_RS05385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EWA66_RS05390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EWA66_RS05395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EWA66_RS05400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EWA66_RS05405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EWA66_RS05415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EWA66_RS05420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EWA66_RS05425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EWA66_RS05430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EWA66_RS05435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EWA66_RS05440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EWA66_RS05445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EWA66_RS05450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EWA66_RS05455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EWA66_RS05460	COG1841	ribosomal large subunit assembly
EWA66_RS05465	COG0200	Binds to the 23S rRNA
EWA66_RS05470	COG0201	protein transport
EWA66_RS05475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EWA66_RS05480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EWA66_RS05485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EWA66_RS05495	COG0202	RNA polymerase activity
EWA66_RS05500	COG0203	ribosomal protein L17
EWA66_RS05505	COG0545	Peptidyl-prolyl cis-trans isomerase
EWA66_RS05515	COG0697	spore germination
EWA66_RS05520	COG2153	protein acetylation
EWA66_RS05530	COG0737	Belongs to the 5'-nucleotidase family
EWA66_RS05535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EWA66_RS05535	COG1648	precorrin-2 dehydrogenase activity
EWA66_RS05545	COG2895	sulfate adenylyltransferase (ATP) activity
EWA66_RS05550	COG0471	metal ion transport
EWA66_RS05550	COG3273	potassium ion transport
EWA66_RS05555	COG0529	Catalyzes the synthesis of activated sulfate
EWA66_RS05575	COG1136	(ABC) transporter
EWA66_RS05575	COG0577	efflux transmembrane transporter activity
EWA66_RS05590	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EWA66_RS05605	COG0729	surface antigen
EWA66_RS05610	COG2911	Protein conserved in bacteria
EWA66_RS05615	COG2105	PFAM AIG2 family protein
EWA66_RS05620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EWA66_RS05625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EWA66_RS05630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EWA66_RS05635	COG0163	prenyltransferase activity
EWA66_RS05645	COG1178	ABC-type Fe3 transport system permease component
EWA66_RS05650	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EWA66_RS05660	COG0312	modulator of DNA gyrase
EWA66_RS05665	COG2239	Acts as a magnesium transporter
EWA66_RS05670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA66_RS05675	COG1660	Displays ATPase and GTPase activities
EWA66_RS05680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA66_RS05685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EWA66_RS05695	COG1137	ATPase activity
EWA66_RS05710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EWA66_RS05715	COG0517	IMP dehydrogenase activity
EWA66_RS05715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EWA66_RS05725	COG1127	ABC transporter
EWA66_RS05730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EWA66_RS05735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EWA66_RS05740	COG2854	intermembrane phospholipid transfer
EWA66_RS05750	COG5007	Belongs to the BolA IbaG family
EWA66_RS05755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EWA66_RS05760	COG0204	Acyl-transferase
EWA66_RS05770	COG1410	methionine synthase
EWA66_RS05770	COG0646	methionine synthase
EWA66_RS05775	COG0527	aspartate kinase activity
EWA66_RS05780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EWA66_RS05790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EWA66_RS05805	COG0629	single-stranded DNA binding
EWA66_RS05810	COG2200	EAL domain
EWA66_RS05810	COG2199	diguanylate cyclase activity
EWA66_RS05835	COG3409	Peptidoglycan-binding domain 1 protein
EWA66_RS05835	COG3267	Type II secretory pathway component ExeA
EWA66_RS05845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EWA66_RS05850	COG1459	type II secretion system
EWA66_RS05865	COG2165	general secretion pathway protein
EWA66_RS05895	COG1077	Cell shape determining protein MreB Mrl
EWA66_RS05900	COG1792	Involved in formation and maintenance of cell shape
EWA66_RS05905	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EWA66_RS05910	COG0424	maF-like protein
EWA66_RS05920	COG3164	Protein of unknown function
EWA66_RS05925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EWA66_RS05930	COG0312	modulator of DNA gyrase
EWA66_RS05935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EWA66_RS05950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EWA66_RS05955	COG0251	oxidation-reduction process
EWA66_RS05960	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EWA66_RS05990	COG0456	acetyltransferase
EWA66_RS06000	COG0525	valine-tRNA ligase activity
EWA66_RS06005	COG2927	DNA polymerase III (CHI subunit)
EWA66_RS06010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EWA66_RS06015	COG0795	lipopolysaccharide-transporting ATPase activity
EWA66_RS06020	COG0795	lipopolysaccharide-transporting ATPase activity
EWA66_RS06080	COG1012	belongs to the aldehyde dehydrogenase family
EWA66_RS06135	COG0741	lytic transglycosylase activity
EWA66_RS06140	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EWA66_RS06150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EWA66_RS06155	COG2066	Belongs to the glutaminase family
EWA66_RS06160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EWA66_RS06165	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EWA66_RS06180	COG0762	integral membrane protein
EWA66_RS06185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EWA66_RS06190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EWA66_RS06205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EWA66_RS06210	COG1678	Uncharacterized ACR, COG1678
EWA66_RS06220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EWA66_RS06230	COG2356	endonuclease I
EWA66_RS06240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EWA66_RS06250	COG0583	DNA-binding transcription factor activity
EWA66_RS06255	COG4771	TonB-dependent receptor
EWA66_RS06260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EWA66_RS06265	COG0126	phosphoglycerate kinase activity
EWA66_RS06270	COG0191	fructose-bisphosphate aldolase activity
EWA66_RS06275	COG0668	transmembrane transport
EWA66_RS06295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EWA66_RS06305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EWA66_RS06315	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EWA66_RS06320	COG3079	Belongs to the UPF0149 family
EWA66_RS06325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWA66_RS06330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWA66_RS06345	COG0354	folic acid binding
EWA66_RS06360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EWA66_RS06365	COG1595	DNA-templated transcription, initiation
EWA66_RS06380	COG3086	response to oxidative stress
EWA66_RS06385	COG0481	GTPase activity
EWA66_RS06390	COG0681	Belongs to the peptidase S26 family
EWA66_RS06400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EWA66_RS06410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EWA66_RS06430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EWA66_RS06435	COG3956	TIGRFAM MazG family protein
EWA66_RS06440	COG0504	CTP synthase activity
EWA66_RS06445	COG0148	phosphopyruvate hydratase activity
EWA66_RS06450	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EWA66_RS06455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EWA66_RS06475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EWA66_RS06485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EWA66_RS06490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EWA66_RS06495	COG1546	Belongs to the CinA family
EWA66_RS06500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EWA66_RS06510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EWA66_RS06515	COG0527	aspartate kinase activity
EWA66_RS06565	COG3630	sodium ion export across plasma membrane
EWA66_RS06570	COG5016	pyruvate
EWA66_RS06570	COG0511	ligase activity, forming carbon-carbon bonds
EWA66_RS06575	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EWA66_RS06585	COG1238	metal cluster binding
EWA66_RS06590	COG0612	Peptidase, M16
EWA66_RS06605	COG1854	S-ribosylhomocysteine lyase activity
EWA66_RS06610	COG4536	flavin adenine dinucleotide binding
EWA66_RS06615	COG4137	Cytochrome C assembly protein
EWA66_RS06620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EWA66_RS06625	COG0228	four-way junction DNA binding
EWA66_RS06630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EWA66_RS06635	COG0336	Belongs to the RNA methyltransferase TrmD family
EWA66_RS06640	COG0335	large ribosomal subunit rRNA binding
EWA66_RS06645	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EWA66_RS06655	COG0237	dephospho-CoA kinase activity
EWA66_RS06665	COG1459	type II secretion system
EWA66_RS06670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EWA66_RS06695	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EWA66_RS06700	COG0508	dehydrogenase complex catalyzes the overall conversion of
EWA66_RS06705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWA66_RS06720	COG0288	reversible hydration of carbon dioxide
EWA66_RS06725	COG0659	secondary active sulfate transmembrane transporter activity
EWA66_RS06730	COG1131	(ABC) transporter
EWA66_RS06735	COG0842	Transport permease protein
EWA66_RS06745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EWA66_RS06750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EWA66_RS06760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EWA66_RS06765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EWA66_RS06775	COG1643	Atp-dependent helicase
EWA66_RS06780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EWA66_RS06785	COG1752	Esterase of the alpha-beta hydrolase superfamily
EWA66_RS06790	COG1049	propionate catabolic process, 2-methylcitrate cycle
EWA66_RS06795	COG1929	Belongs to the glycerate kinase type-1 family
EWA66_RS06800	COG3112	Uncharacterised protein family (UPF0231)
EWA66_RS06835	COG1121	(ABC) transporter
EWA66_RS06840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EWA66_RS06850	COG0745	RESPONSE REGULATOR receiver
EWA66_RS06860	COG4771	TonB-dependent receptor
EWA66_RS06865	COG0347	Belongs to the P(II) protein family
EWA66_RS06870	COG0004	ammonium transporteR
EWA66_RS06875	COG1840	ABC-type Fe3 transport system, periplasmic component
EWA66_RS06885	COG3842	ATPase activity
EWA66_RS06890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EWA66_RS06905	COG2971	BadF BadG BcrA BcrD
EWA66_RS06915	COG4608	Belongs to the ABC transporter superfamily
EWA66_RS06920	COG0444	Belongs to the ABC transporter superfamily
EWA66_RS06925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA66_RS06930	COG0601	transmembrane transport
EWA66_RS06935	COG0747	negative chemotaxis
EWA66_RS06940	COG2205	protein histidine kinase activity
EWA66_RS06940	COG0784	Response regulator, receiver
EWA66_RS06950	COG0628	permease
EWA66_RS06955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EWA66_RS06975	COG0739	heme binding
EWA66_RS06980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EWA66_RS06985	COG2027	D-alanyl-D-alanine carboxypeptidase
EWA66_RS06990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EWA66_RS06995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EWA66_RS07000	COG1534	Rna-binding protein
EWA66_RS07010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EWA66_RS07020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EWA66_RS07025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EWA66_RS07040	COG0779	Required for maturation of 30S ribosomal subunits
EWA66_RS07045	COG0195	Participates in both transcription termination and antitermination
EWA66_RS07055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EWA66_RS07060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EWA66_RS07065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EWA66_RS07070	COG1185	polyribonucleotide nucleotidyltransferase activity
EWA66_RS07085	COG0534	Mate efflux family protein
EWA66_RS07090	COG0826	peptidase U32
EWA66_RS07095	COG0826	peptidase U32
EWA66_RS07105	COG3154	lipid carrier protein
EWA66_RS07110	COG3153	acetyltransferase
EWA66_RS07135	COG0084	hydrolase, TatD family'
EWA66_RS07140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EWA66_RS07145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EWA66_RS07150	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EWA66_RS07155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EWA66_RS07160	COG0813	purine-nucleoside phosphorylase activity
EWA66_RS07170	COG0560	Phosphoserine phosphatase
EWA66_RS07180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EWA66_RS07185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EWA66_RS07190	COG0583	DNA-binding transcription factor activity
EWA66_RS07205	COG2059	Chromate
EWA66_RS07210	COG0583	DNA-binding transcription factor activity
EWA66_RS07240	COG0456	acetyltransferase
EWA66_RS07250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EWA66_RS07255	COG1349	DNA-binding transcription factor activity
EWA66_RS07260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EWA66_RS07265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EWA66_RS07270	COG2171	N-acyltransferase activity
EWA66_RS07275	COG3141	response to X-ray
EWA66_RS07290	COG3083	sulfuric ester hydrolase activity
EWA66_RS07295	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EWA66_RS07300	COG1074	ATP-dependent DNA helicase activity
EWA66_RS07305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EWA66_RS07325	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EWA66_RS07330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EWA66_RS07335	COG2166	iron-sulfur cluster assembly
EWA66_RS07340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EWA66_RS07350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EWA66_RS07365	COG1595	DNA-templated transcription, initiation
EWA66_RS07390	COG2813	Specifically methylates the guanine in position
EWA66_RS07395	COG0271	Belongs to the BolA IbaG family
EWA66_RS07400	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EWA66_RS07405	COG1805	sodium ion transport
EWA66_RS07415	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EWA66_RS07420	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EWA66_RS07425	COG2871	sodium ion transport
EWA66_RS07430	COG1477	protein flavinylation
EWA66_RS07445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EWA66_RS07450	COG0514	ATP-dependent DNA helicase (RecQ)
EWA66_RS07485	COG1720	tRNA m6t6A37 methyltransferase activity
EWA66_RS07490	COG0254	rRNA binding
EWA66_RS07495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EWA66_RS07500	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EWA66_RS07530	COG3098	single-species biofilm formation
EWA66_RS07545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EWA66_RS07550	COG0024	Methionine aminopeptidase
EWA66_RS07555	COG0052	Belongs to the universal ribosomal protein uS2 family
EWA66_RS07560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EWA66_RS07570	COG0233	cytoplasmic translational termination
EWA66_RS07575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EWA66_RS07580	COG0575	Belongs to the CDS family
EWA66_RS07590	COG0750	zinc metalloprotease
EWA66_RS07600	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EWA66_RS07605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA66_RS07610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EWA66_RS07615	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA66_RS07620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA66_RS07630	COG0587	DNA-directed DNA polymerase activity
EWA66_RS07635	COG0825	malonyl-CoA metabolic process
EWA66_RS07650	COG0347	Belongs to the P(II) protein family
EWA66_RS07655	COG3021	interspecies interaction between organisms
EWA66_RS07665	COG1388	LysM domain
EWA66_RS07665	COG0741	lytic transglycosylase activity
EWA66_RS07670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWA66_RS07675	COG2226	methyltransferase
EWA66_RS07680	COG0328	RNA-DNA hybrid ribonuclease activity
EWA66_RS07695	COG1960	acyl-CoA dehydrogenase activity
EWA66_RS07705	COG0121	glutamine amidotransferase
EWA66_RS07710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EWA66_RS07715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EWA66_RS07720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EWA66_RS07725	COG2233	PERMEase
EWA66_RS07745	COG1393	Belongs to the ArsC family
EWA66_RS07750	COG4783	chaperone-mediated protein folding
EWA66_RS07765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EWA66_RS07770	COG2716	regulation of RNA biosynthetic process
EWA66_RS07775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EWA66_RS07780	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EWA66_RS07800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EWA66_RS07805	COG1393	Belongs to the ArsC family
EWA66_RS07835	COG2837	iron assimilation
EWA66_RS07840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA66_RS07845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA66_RS07850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA66_RS07855	COG1334	flagellar protein FlaG
EWA66_RS07860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EWA66_RS07870	COG1516	flagellar protein fliS
EWA66_RS07890	COG1677	Flagellar hook-basal body complex protein FliE
EWA66_RS07900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EWA66_RS07950	COG1987	bacterial-type flagellum assembly
EWA66_RS07955	COG1684	flagellar biosynthetic protein fliR
EWA66_RS07990	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EWA66_RS07995	COG0784	Response regulator, receiver
EWA66_RS07995	COG0643	Histidine kinase
EWA66_RS07995	COG2198	Histidine kinase
EWA66_RS08000	COG2201	protein-glutamate methylesterase activity
EWA66_RS08005	COG1192	Involved in chromosome partitioning
EWA66_RS08015	COG0835	chemotaxis
EWA66_RS08025	COG4133	protoheme IX ABC transporter activity
EWA66_RS08030	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EWA66_RS08040	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EWA66_RS08045	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EWA66_RS08050	COG1138	Cytochrome C-type biogenesis protein
EWA66_RS08055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EWA66_RS08070	COG2853	Lipoprotein
EWA66_RS08080	COG2067	long-chain fatty acid transport protein
EWA66_RS08090	COG1595	DNA-templated transcription, initiation
EWA66_RS08095	COG0183	Belongs to the thiolase family
EWA66_RS08100	COG1250	3-hydroxyacyl-CoA dehydrogenase
EWA66_RS08100	COG1024	Enoyl-CoA hydratase
EWA66_RS08105	COG1025	Belongs to the peptidase M16 family
EWA66_RS08110	COG2062	phosphohistidine phosphatase, SixA
EWA66_RS08115	COG2840	Smr protein MutS2
EWA66_RS08120	COG2890	protein-(glutamine-N5) methyltransferase activity
EWA66_RS08125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EWA66_RS08130	COG0583	DNA-binding transcription factor activity
EWA66_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
EWA66_RS08145	COG3101	peptidyl-lysine hydroxylation
EWA66_RS08160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EWA66_RS08160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EWA66_RS08165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EWA66_RS08175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EWA66_RS08185	COG0101	tRNA pseudouridine synthase activity
EWA66_RS08190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EWA66_RS08195	COG0285	dihydrofolate synthase activity
EWA66_RS08200	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EWA66_RS08205	COG1286	toxin biosynthetic process
EWA66_RS08210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EWA66_RS08215	COG0583	DNA-binding transcription factor activity
EWA66_RS08220	COG0745	RESPONSE REGULATOR receiver
EWA66_RS08230	COG2832	Protein of unknown function (DUF454)
EWA66_RS08235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EWA66_RS08245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EWA66_RS08250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EWA66_RS08265	COG2205	protein histidine kinase activity
EWA66_RS08270	COG0745	RESPONSE REGULATOR receiver
EWA66_RS08280	COG2983	Belongs to the UPF0260 family
EWA66_RS08285	COG1785	Belongs to the alkaline phosphatase family
EWA66_RS08300	COG2226	methyltransferase
EWA66_RS08305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EWA66_RS08330	COG2239	Acts as a magnesium transporter
EWA66_RS08335	COG1285	pathogenesis
EWA66_RS08340	COG2873	o-acetylhomoserine
EWA66_RS08350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EWA66_RS08370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EWA66_RS08385	COG3139	Protein of unknown function (DUF1315)
EWA66_RS08390	COG0252	asparaginase activity
EWA66_RS08395	COG0616	signal peptide processing
EWA66_RS08400	COG1902	pentaerythritol trinitrate reductase activity
EWA66_RS08400	COG0446	pyridine nucleotide-disulphide oxidoreductase
EWA66_RS08405	COG3344	reverse transcriptase
EWA66_RS08410	COG0778	Nitroreductase
EWA66_RS08415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EWA66_RS08435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWA66_RS08440	COG3083	sulfuric ester hydrolase activity
EWA66_RS08450	COG3081	Nucleoid-associated protein
EWA66_RS08460	COG1757	Na H antiporter
EWA66_RS08465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EWA66_RS08470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWA66_RS08475	COG2095	MarC family integral membrane protein
EWA66_RS08480	COG1454	alcohol dehydrogenase
EWA66_RS08480	COG1012	belongs to the aldehyde dehydrogenase family
EWA66_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
EWA66_RS08500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EWA66_RS08510	COG2056	Na+-H+ antiporter family
EWA66_RS08515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EWA66_RS08520	COG2885	chlorophyll binding
EWA66_RS08530	COG0346	lactoylglutathione lyase activity
EWA66_RS08535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EWA66_RS08540	COG4660	Part of a membrane complex involved in electron transport
EWA66_RS08545	COG4659	FMN binding
EWA66_RS08550	COG4658	electron transport chain
EWA66_RS08555	COG4656	Part of a membrane complex involved in electron transport
EWA66_RS08560	COG2878	Part of a membrane complex involved in electron transport
EWA66_RS08565	COG4657	Part of a membrane complex involved in electron transport
EWA66_RS08575	COG1566	PFAM secretion protein HlyD family protein
EWA66_RS08580	COG2814	Major facilitator Superfamily
EWA66_RS08590	COG0556	nucleotide-excision repair
EWA66_RS08595	COG2204	response regulator
EWA66_RS08600	COG2198	Histidine kinase
EWA66_RS08605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EWA66_RS08610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EWA66_RS08615	COG0521	Mo-molybdopterin cofactor biosynthetic process
EWA66_RS08625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EWA66_RS08630	COG0314	molybdopterin synthase activity
EWA66_RS08640	COG0601	transmembrane transport
EWA66_RS08645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA66_RS08650	COG0444	Belongs to the ABC transporter superfamily
EWA66_RS08665	COG3174	membrane
EWA66_RS08670	COG0280	phosphate acetyltransferase
EWA66_RS08670	COG0857	belongs to the CobB CobQ family
EWA66_RS08675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EWA66_RS08680	COG3092	negative regulation of chromosome organization
EWA66_RS08690	COG4120	Belongs to the binding-protein-dependent transport system permease family
EWA66_RS08700	COG0366	Alpha amylase catalytic
EWA66_RS08710	COG0653	protein targeting
EWA66_RS08720	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EWA66_RS08725	COG2186	Transcriptional regulator
EWA66_RS08735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWA66_RS08735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWA66_RS08740	COG0489	protein tyrosine kinase activity
EWA66_RS08745	COG0572	uridine kinase
EWA66_RS08755	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EWA66_RS08760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EWA66_RS08765	COG1530	ribonuclease E activity
EWA66_RS08775	COG0424	maF-like protein
EWA66_RS08780	COG1399	metal-binding, possibly nucleic acid-binding protein
EWA66_RS08785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EWA66_RS08790	COG0416	fatty acid biosynthetic process
EWA66_RS08795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EWA66_RS08810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EWA66_RS08825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EWA66_RS08830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EWA66_RS08840	COG0084	hydrolase, TatD family'
EWA66_RS08845	COG1263	PTS System
EWA66_RS08845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA66_RS08855	COG0733	neurotransmitter:sodium symporter activity
EWA66_RS08870	COG4667	esterase of the alpha-beta hydrolase superfamily
EWA66_RS08875	COG0469	pyruvate kinase activity
EWA66_RS08880	COG1940	carbohydrate kinase activity
EWA66_RS08885	COG0784	Response regulator, receiver
EWA66_RS08885	COG0835	chemotaxis
EWA66_RS08890	COG0587	DNA-directed DNA polymerase activity
EWA66_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
EWA66_RS08910	COG0616	signal peptide processing
EWA66_RS08920	COG0539	negative regulation of cytoplasmic translation
EWA66_RS08930	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EWA66_RS08935	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EWA66_RS08950	COG4239	(ABC) transporter, permease
EWA66_RS08955	COG4166	transmembrane transport
EWA66_RS08960	COG0444	Belongs to the ABC transporter superfamily
EWA66_RS08965	COG4608	Belongs to the ABC transporter superfamily
EWA66_RS08990	COG0583	DNA-binding transcription factor activity
EWA66_RS09000	COG0686	Belongs to the AlaDH PNT family
EWA66_RS09005	COG1522	sequence-specific DNA binding
EWA66_RS09020	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EWA66_RS09025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EWA66_RS09035	COG3344	reverse transcriptase
EWA66_RS09045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EWA66_RS09050	COG0156	8-amino-7-oxononanoate synthase activity
EWA66_RS09055	COG2226	methyltransferase
EWA66_RS09060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EWA66_RS09065	COG0501	Belongs to the peptidase M48B family
EWA66_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
EWA66_RS09090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EWA66_RS09100	COG2268	Band 7 protein
EWA66_RS09110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EWA66_RS09115	COG2915	High frequency lysogenization protein hflD homolog
EWA66_RS09120	COG0482	sulfurtransferase activity
EWA66_RS09130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA66_RS09140	COG1757	Na H antiporter
EWA66_RS09145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EWA66_RS09150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EWA66_RS09155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EWA66_RS09160	COG0131	Imidazoleglycerol-phosphate dehydratase
EWA66_RS09160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EWA66_RS09165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EWA66_RS09170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EWA66_RS09180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EWA66_RS09180	COG0140	phosphoribosyl-ATP diphosphatase activity
EWA66_RS09185	COG3012	SEC-C Motif Domain Protein
EWA66_RS09190	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EWA66_RS09195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA66_RS09200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EWA66_RS09205	COG0215	cysteine-tRNA ligase activity
EWA66_RS09210	COG1435	thymidine kinase activity
EWA66_RS09215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWA66_RS09235	COG2116	formate transmembrane transporter activity
EWA66_RS09240	COG3344	reverse transcriptase
EWA66_RS09245	COG4459	periplasmic nitrate reductase
EWA66_RS09250	COG3005	denitrification pathway
EWA66_RS09270	COG1227	inorganic diphosphatase activity
EWA66_RS09285	COG4172	Belongs to the ABC transporter superfamily
EWA66_RS09310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EWA66_RS09315	COG1842	Phage shock protein A
EWA66_RS09325	COG1983	PspC domain protein
EWA66_RS09330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWA66_RS09345	COG2818	Glycosylase
EWA66_RS09350	COG0626	cystathionine gamma-synthase activity
EWA66_RS09360	COG0733	neurotransmitter:sodium symporter activity
EWA66_RS09365	COG0564	pseudouridine synthase activity
EWA66_RS09380	COG3313	Fe-S protein
EWA66_RS09390	COG0737	Belongs to the 5'-nucleotidase family
EWA66_RS09395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EWA66_RS09400	COG5002	protein histidine kinase activity
EWA66_RS09415	COG1061	Type III restriction enzyme res subunit
EWA66_RS09425	COG2814	Major facilitator Superfamily
EWA66_RS09435	COG0702	epimerase
EWA66_RS09440	COG0534	Mate efflux family protein
EWA66_RS09460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EWA66_RS09480	COG3273	potassium ion transport
EWA66_RS09480	COG2985	domain, Protein
EWA66_RS09485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EWA66_RS09490	COG1012	belongs to the aldehyde dehydrogenase family
EWA66_RS09490	COG1454	alcohol dehydrogenase
EWA66_RS09495	COG1737	Transcriptional regulator
EWA66_RS09500	COG0076	glutamate decarboxylase activity
EWA66_RS09510	COG2431	L-lysine efflux transmembrane transporter activity
EWA66_RS09520	COG3070	regulator of competence-specific genes
EWA66_RS09535	COG5002	protein histidine kinase activity
EWA66_RS09535	COG5002	protein histidine kinase activity
EWA66_RS09545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EWA66_RS09550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EWA66_RS09555	COG4988	ABC transporter
EWA66_RS09560	COG0492	ferredoxin-NADP+ reductase activity
EWA66_RS09585	COG0471	metal ion transport
EWA66_RS09590	COG2949	membrane
EWA66_RS09595	COG0281	malic enzyme
EWA66_RS09600	COG1643	Atp-dependent helicase
EWA66_RS09615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EWA66_RS09635	COG2885	chlorophyll binding
EWA66_RS09645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EWA66_RS09650	COG4136	ATPase activity
EWA66_RS09655	COG4135	transport system, permease component
EWA66_RS09660	COG4134	Bacterial extracellular solute-binding protein
EWA66_RS09670	COG0277	FAD linked oxidase domain protein
EWA66_RS09670	COG0247	lactate metabolic process
EWA66_RS09690	COG2986	histidine ammonia-lyase
EWA66_RS09695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EWA66_RS09700	COG0010	Belongs to the arginase family
EWA66_RS09750	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EWA66_RS09755	COG1280	lysine exporter protein (LysE YggA)
EWA66_RS09765	COG1115	amino acid carrier protein
EWA66_RS09785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWA66_RS09800	COG3290	protein histidine kinase activity
EWA66_RS09805	COG4565	transcriptional regulatory protein
EWA66_RS09810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EWA66_RS09815	COG0363	glucosamine-6-phosphate deaminase activity
EWA66_RS09820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EWA66_RS09885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA66_RS09920	COG2161	toxin-antitoxin pair type II binding
EWA66_RS09925	COG4115	mRNA cleavage
EWA66_RS10135	COG4916	TIR domain
EWA66_RS10150	COG5433	transposase activity
EWA66_RS10175	COG5433	transposase activity
EWA66_RS10240	COG4916	TIR domain
EWA66_RS10315	COG2161	toxin-antitoxin pair type II binding
EWA66_RS10320	COG4115	mRNA cleavage
EWA66_RS10420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA66_RS10485	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EWA66_RS10490	COG2944	sequence-specific DNA binding
EWA66_RS10500	COG5433	transposase activity
EWA66_RS10585	COG2026	Addiction module toxin, RelE StbE family
EWA66_RS10605	COG2026	Addiction module toxin, RelE StbE family
EWA66_RS10640	COG2026	Addiction module toxin, RelE StbE family
EWA66_RS10870	COG5433	transposase activity
EWA66_RS10965	COG5433	transposase activity
EWA66_RS11115	COG0454	-acetyltransferase
EWA66_RS11365	COG5433	transposase activity
EWA66_RS11370	COG4628	conserved protein (DUF2132)
EWA66_RS11425	COG1609	Transcriptional regulator
EWA66_RS11435	COG2814	Major facilitator Superfamily
EWA66_RS11445	COG1760	l-serine dehydratase
EWA66_RS11460	COG2723	6-phospho-beta-galactosidase activity
EWA66_RS11465	COG1609	Transcriptional regulator
EWA66_RS11470	COG0584	glycerophosphoryl diester phosphodiesterase
EWA66_RS11490	COG1793	dna ligase
EWA66_RS11500	COG0534	Mate efflux family protein
EWA66_RS11505	COG0307	riboflavin synthase, alpha
EWA66_RS11525	COG3706	GGDEF domain
EWA66_RS11535	COG0791	NLP P60 protein
EWA66_RS11550	COG3148	PFAM DTW domain containing protein
EWA66_RS11555	COG1940	carbohydrate kinase activity
EWA66_RS11565	COG1763	Mo-molybdopterin cofactor biosynthetic process
EWA66_RS11570	COG0746	molybdenum cofactor guanylyltransferase activity
EWA66_RS11575	COG0488	(ABC) transporter
EWA66_RS11590	COG0004	ammonium transporteR
EWA66_RS11600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EWA66_RS11605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EWA66_RS11610	COG1177	transmembrane transport
EWA66_RS11620	COG3842	ATPase activity
EWA66_RS11630	COG2992	FlgJ-related protein
EWA66_RS11645	COG0589	response to stress
EWA66_RS11650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWA66_RS11665	COG2217	Heavy metal translocating P-type atpase
EWA66_RS11675	COG2010	Cytochrome c
EWA66_RS11690	COG3278	Belongs to the heme-copper respiratory oxidase family
EWA66_RS11705	COG0784	Response regulator, receiver
EWA66_RS11705	COG2205	protein histidine kinase activity
EWA66_RS11710	COG2801	Transposase and inactivated derivatives
EWA66_RS11730	COG3120	sequence-specific DNA binding
EWA66_RS11735	COG1067	ATP-dependent peptidase activity
EWA66_RS11740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EWA66_RS11755	COG0488	(ABC) transporter
EWA66_RS11765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EWA66_RS11765	COG0116	Belongs to the methyltransferase superfamily
EWA66_RS11775	COG0167	dihydroorotate dehydrogenase activity
EWA66_RS11790	COG0308	aminopeptidase N
EWA66_RS11805	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EWA66_RS11810	COG1956	GAF domain-containing protein
EWA66_RS11815	COG1132	(ABC) transporter
EWA66_RS11820	COG2995	paraquat-inducible protein a
EWA66_RS11830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EWA66_RS11830	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EWA66_RS11835	COG2996	Protein conserved in bacteria
EWA66_RS11860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EWA66_RS11875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA66_RS11880	COG4597	amino acid ABC transporter
EWA66_RS11885	COG0765	amino acid transport
EWA66_RS11890	COG1126	abc transporter atp-binding protein
EWA66_RS11895	COG0670	Belongs to the BI1 family
EWA66_RS11900	COG3344	reverse transcriptase
EWA66_RS11905	COG2920	part of a sulfur-relay system
EWA66_RS11910	COG1254	Belongs to the acylphosphatase family
EWA66_RS11920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EWA66_RS11950	COG3706	GGDEF domain
EWA66_RS11955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EWA66_RS11960	COG0602	queuosine metabolic process
EWA66_RS11965	COG0561	phosphatase activity
EWA66_RS11985	COG2828	Protein conserved in bacteria
EWA66_RS11990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EWA66_RS11995	COG0372	Belongs to the citrate synthase family
EWA66_RS12000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EWA66_RS12025	COG0730	response to heat
EWA66_RS12040	COG1278	Cold shock
EWA66_RS12060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EWA66_RS12090	COG0625	glutathione transferase activity
EWA66_RS12100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EWA66_RS12120	COG3063	Type IV pilus biogenesis stability protein PilW
EWA66_RS12135	COG1451	nucleotide metabolic process
EWA66_RS12165	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EWA66_RS12175	COG2988	succinylglutamate desuccinylase activity
EWA66_RS12185	COG0406	alpha-ribazole phosphatase activity
EWA66_RS12195	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EWA66_RS12205	COG0702	epimerase
EWA66_RS12210	COG2925	Exonuclease
EWA66_RS12215	COG1380	Effector of murein hydrolase LrgA
EWA66_RS12220	COG1346	cytolysis
EWA66_RS12225	COG0295	cytidine deaminase activity
EWA66_RS12230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EWA66_RS12235	COG0500	methyltransferase
EWA66_RS12245	COG0776	regulation of translation
EWA66_RS12265	COG2200	EAL domain
EWA66_RS12270	COG0072	phenylalanine-tRNA ligase activity
EWA66_RS12270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWA66_RS12275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EWA66_RS12325	COG1166	arginine decarboxylase activity
EWA66_RS12330	COG0010	Belongs to the arginase family
EWA66_RS12335	COG2814	Major facilitator Superfamily
EWA66_RS12345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EWA66_RS12370	COG1643	Atp-dependent helicase
EWA66_RS12375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EWA66_RS12415	COG0443	Heat shock 70 kDa protein
EWA66_RS12420	COG1280	lysine exporter protein (LysE YggA)
EWA66_RS12445	COG3568	Endonuclease Exonuclease Phosphatase
EWA66_RS12465	COG1132	(ABC) transporter
EWA66_RS12470	COG1132	(ABC) transporter
EWA66_RS12480	COG3344	reverse transcriptase
EWA66_RS12490	COG0783	Belongs to the Dps family
EWA66_RS12500	COG0814	amino acid
EWA66_RS12505	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EWA66_RS12520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EWA66_RS12525	COG1328	CTP reductase activity
EWA66_RS12530	COG3300	MHYT domain
EWA66_RS12530	COG5001	Diguanylate cyclase
EWA66_RS12545	COG5001	Diguanylate cyclase
EWA66_RS12545	COG3300	MHYT domain
EWA66_RS12550	COG3706	GGDEF domain
EWA66_RS12555	COG2204	response regulator
EWA66_RS12560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA66_RS12560	COG4191	Histidine kinase
EWA66_RS12565	COG0471	metal ion transport
EWA66_RS12580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA66_RS12590	COG3768	UPF0283 membrane protein
EWA66_RS12595	COG3106	COG3106 Predicted ATPase
EWA66_RS12615	COG0494	nUDIX hydrolase
EWA66_RS12620	COG0814	amino acid
EWA66_RS12625	COG1760	l-serine dehydratase
EWA66_RS12645	COG0720	synthase
EWA66_RS12655	COG0017	Asparaginyl-tRNA synthetase
EWA66_RS12665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EWA66_RS12675	COG2770	Histidine kinase
EWA66_RS12675	COG3437	response regulator, receiver
EWA66_RS12680	COG1448	Aminotransferase
EWA66_RS12700	COG0840	transmembrane signaling receptor activity
EWA66_RS12705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EWA66_RS12710	COG1846	Transcriptional regulator
EWA66_RS12735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EWA66_RS12750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWA66_RS12755	COG3108	Peptidase M15
EWA66_RS12760	COG2989	Protein conserved in bacteria
EWA66_RS12785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EWA66_RS12800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EWA66_RS12805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EWA66_RS12880	COG0322	excinuclease ABC activity
EWA66_RS12885	COG2197	response regulator
EWA66_RS12890	COG0417	DNA replication proofreading
EWA66_RS12905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EWA66_RS12920	COG0009	L-threonylcarbamoyladenylate synthase
EWA66_RS12925	COG0613	PHP domain protein
EWA66_RS12935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EWA66_RS12940	COG0512	Glutamine amidotransferase of anthranilate synthase
EWA66_RS12950	COG0135	phosphoribosylanthranilate isomerase activity
EWA66_RS12950	COG0134	indole-3-glycerol-phosphate synthase activity
EWA66_RS12955	COG0133	tryptophan synthase activity
EWA66_RS12960	COG0159	tryptophan synthase activity
EWA66_RS12965	COG1301	dicarboxylic acid transport
EWA66_RS12985	COG2350	Protein conserved in bacteria
EWA66_RS13000	COG0583	DNA-binding transcription factor activity
EWA66_RS13085	COG2199	diguanylate cyclase activity
EWA66_RS13085	COG2203	Gaf domain
EWA66_RS13095	COG0415	Belongs to the DNA photolyase family
EWA66_RS13105	COG0840	transmembrane signaling receptor activity
EWA66_RS13120	COG1858	cytochrome C peroxidase
EWA66_RS13130	COG2197	response regulator
EWA66_RS13135	COG3851	Histidine kinase
EWA66_RS13140	COG2271	Major facilitator Superfamily
EWA66_RS13145	COG1482	cell wall glycoprotein biosynthetic process
EWA66_RS13170	COG2801	Transposase and inactivated derivatives
EWA66_RS13175	COG0482	sulfurtransferase activity
EWA66_RS13190	COG1104	cysteine desulfurase activity
EWA66_RS13210	COG0784	Response regulator, receiver
EWA66_RS13210	COG5002	protein histidine kinase activity
EWA66_RS13230	COG1858	cytochrome C peroxidase
EWA66_RS13250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EWA66_RS13255	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EWA66_RS13260	COG2885	chlorophyll binding
EWA66_RS13265	COG0823	Involved in the tonB-independent uptake of proteins
EWA66_RS13280	COG0811	peptide transport
EWA66_RS13285	COG0824	Thioesterase
EWA66_RS13290	COG3344	reverse transcriptase
EWA66_RS13300	COG4890	Cyd operon protein YbgT
EWA66_RS13305	COG1294	oxidase, subunit
EWA66_RS13310	COG1271	oxidase subunit
EWA66_RS13315	COG2255	four-way junction helicase activity
EWA66_RS13320	COG0632	four-way junction helicase activity
EWA66_RS13325	COG0840	transmembrane signaling receptor activity
EWA66_RS13330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EWA66_RS13340	COG1801	Protein of unknown function DUF72
EWA66_RS13355	COG4067	protein conserved in archaea
EWA66_RS13355	COG0189	ligase activity
EWA66_RS13375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EWA66_RS13380	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EWA66_RS13390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EWA66_RS13395	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EWA66_RS13400	COG0745	RESPONSE REGULATOR receiver
EWA66_RS13405	COG3381	protein complex oligomerization
EWA66_RS13410	COG1609	Transcriptional regulator
EWA66_RS13415	COG3070	regulator of competence-specific genes
EWA66_RS13435	COG0297	glycogen (starch) synthase activity
EWA66_RS13440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EWA66_RS13445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EWA66_RS13455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EWA66_RS13470	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EWA66_RS13475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EWA66_RS13480	COG0542	response to heat
EWA66_RS13490	COG1278	Cold shock
EWA66_RS13505	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EWA66_RS13510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EWA66_RS13515	COG1199	ATP-dependent helicase activity
EWA66_RS13525	COG3923	Primosomal replication protein n
EWA66_RS13535	COG0840	transmembrane signaling receptor activity
EWA66_RS13540	COG0708	Exodeoxyribonuclease III
EWA66_RS13550	COG4160	amino acid transport
EWA66_RS13555	COG4215	(ABC) transporter
EWA66_RS13585	COG1882	Formate acetyltransferase
EWA66_RS13600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EWA66_RS13610	COG3013	Belongs to the UPF0304 family
EWA66_RS13615	COG2766	serine protein kinase
EWA66_RS13620	COG2718	Belongs to the UPF0229 family
EWA66_RS13625	COG2719	SpoVR family
EWA66_RS13630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EWA66_RS13635	COG2835	tetraacyldisaccharide 4'-kinase activity
EWA66_RS13640	COG1663	tetraacyldisaccharide 4'-kinase activity
EWA66_RS13645	COG1132	(ABC) transporter
EWA66_RS13650	COG2333	competence protein COMEC
EWA66_RS13650	COG0658	competence protein
EWA66_RS13660	COG4591	ABC-type transport system involved in lipoprotein release permease component
EWA66_RS13665	COG1136	(ABC) transporter
EWA66_RS13670	COG4591	ABC-type transport system involved in lipoprotein release permease component
EWA66_RS13680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EWA66_RS13695	COG1054	Belongs to the UPF0176 family
EWA66_RS13700	COG1252	NADH dehydrogenase
EWA66_RS13730	COG0537	adenosine 5'-monophosphoramidase activity
EWA66_RS13745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EWA66_RS13755	COG0517	IMP dehydrogenase activity
EWA66_RS13755	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EWA66_RS13755	COG0617	tRNA 3'-terminal CCA addition
EWA66_RS13825	COG2207	Transcriptional regulator
EWA66_RS13835	COG0861	Integral membrane protein TerC family
EWA66_RS13870	COG1946	Acyl-CoA thioesterase
EWA66_RS13875	COG1522	sequence-specific DNA binding
EWA66_RS13890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWA66_RS13930	COG0477	Major facilitator Superfamily
EWA66_RS13955	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EWA66_RS13960	COG0596	Alpha beta hydrolase
EWA66_RS13965	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EWA66_RS13970	COG1169	isochorismate synthase
EWA66_RS13975	COG0436	Aminotransferase
EWA66_RS13980	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EWA66_RS13985	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EWA66_RS14005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EWA66_RS14010	COG0776	regulation of translation
EWA66_RS14015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EWA66_RS14020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EWA66_RS14040	COG4191	Histidine kinase
EWA66_RS14050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EWA66_RS14055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EWA66_RS14060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EWA66_RS14065	COG3842	ATPase activity
EWA66_RS14070	COG0395	ABC-type sugar transport system, permease component
EWA66_RS14075	COG1175	transmembrane transport
EWA66_RS14110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EWA66_RS14115	COG0583	DNA-binding transcription factor activity
EWA66_RS14120	COG2951	lytic endotransglycosylase activity
EWA66_RS14125	COG3100	YcgL domain-containing protein
EWA66_RS14130	COG0850	regulation of cytokinetic process
EWA66_RS14135	COG2894	cell division
EWA66_RS14140	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EWA66_RS14145	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EWA66_RS14150	COG0318	PFAM AMP-dependent synthetase and ligase
EWA66_RS14155	COG2267	carboxylic ester hydrolase activity
EWA66_RS14160	COG3065	identical protein binding
EWA66_RS14170	COG1214	PFAM Peptidase M22, glycoprotease
EWA66_RS14175	COG1199	ATP-dependent helicase activity
EWA66_RS14185	COG0788	formyltetrahydrofolate deformylase activity
EWA66_RS14210	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EWA66_RS14215	COG1918	ferrous iron import across plasma membrane
EWA66_RS14225	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EWA66_RS14230	COG1121	(ABC) transporter
EWA66_RS14235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EWA66_RS14250	COG0508	dehydrogenase complex catalyzes the overall conversion of
EWA66_RS14255	COG0567	Dehydrogenase, E1 component
EWA66_RS14265	COG1053	succinate dehydrogenase
EWA66_RS14270	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EWA66_RS14285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EWA66_RS14295	COG0033	Phosphoglucomutase
EWA66_RS14300	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EWA66_RS14305	COG0596	Alpha beta hydrolase
EWA66_RS14315	COG0716	FMN binding
EWA66_RS14320	COG1346	cytolysis
EWA66_RS14325	COG1380	Effector of murein hydrolase LrgA
EWA66_RS14330	COG0583	DNA-binding transcription factor activity
EWA66_RS14345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EWA66_RS14350	COG1263	PTS System
EWA66_RS14350	COG2190	(PTS) system
EWA66_RS14350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA66_RS14355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EWA66_RS14360	COG1940	carbohydrate kinase activity
EWA66_RS14360	COG1846	Transcriptional regulator
EWA66_RS14370	COG0367	asparagine synthase
EWA66_RS14380	COG3104	oligopeptide transport
EWA66_RS14385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EWA66_RS14395	COG0326	Molecular chaperone. Has ATPase activity
EWA66_RS14400	COG3710	Transcriptional regulator
EWA66_RS14420	COG0622	Phosphoesterase
EWA66_RS14445	COG1090	epimerase
EWA66_RS14450	COG0300	oxidoreductase activity
EWA66_RS14460	COG3118	belongs to the thioredoxin family
EWA66_RS14465	COG0330	HflC and HflK could
EWA66_RS14490	COG3115	cell septum assembly
EWA66_RS14495	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EWA66_RS14500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EWA66_RS14505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA66_RS14510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EWA66_RS14515	COG2190	(PTS) system
EWA66_RS14520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA66_RS14525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA66_RS14530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA66_RS14535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EWA66_RS14545	COG3951	Flagellar rod assembly protein muramidase FlgJ
EWA66_RS14545	COG1705	Flagellar rod assembly protein muramidase FlgJ
EWA66_RS14550	COG1706	bacterial-type flagellum-dependent cell motility
EWA66_RS14565	COG4787	bacterial-type flagellum-dependent cell motility
EWA66_RS14585	COG1815	bacterial-type flagellum-dependent cell motility
EWA66_RS14590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EWA66_RS14595	COG0784	Response regulator, receiver
EWA66_RS14595	COG0835	chemotaxis
EWA66_RS14645	COG2608	mercury ion transmembrane transporter activity
EWA66_RS14645	COG2217	Heavy metal translocating P-type atpase
EWA66_RS14685	COG3772	lysozyme
EWA66_RS14800	COG1063	alcohol dehydrogenase
EWA66_RS14855	COG1278	Cold shock
EWA66_RS14870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EWA66_RS14885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EWA66_RS14890	COG0459	protein refolding
EWA66_RS14910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EWA66_RS14915	COG1263	PTS System
EWA66_RS14915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA66_RS14920	COG1472	Belongs to the glycosyl hydrolase 3 family
EWA66_RS14950	COG2207	Transcriptional regulator
EWA66_RS14955	COG0783	Belongs to the Dps family
EWA66_RS15005	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EWA66_RS15025	COG1917	Cupin 2, conserved barrel domain protein
EWA66_RS15025	COG4977	sequence-specific DNA binding
EWA66_RS15030	COG1335	isochorismatase
EWA66_RS15045	COG1301	dicarboxylic acid transport
EWA66_RS15075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EWA66_RS15090	COG2356	endonuclease I
EWA66_RS15105	COG2194	sulfuric ester hydrolase activity
EWA66_RS15110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EWA66_RS15115	COG2205	protein histidine kinase activity
EWA66_RS15120	COG0745	RESPONSE REGULATOR receiver
EWA66_RS15125	COG2910	NAD(P)H-binding
EWA66_RS15140	COG0076	glutamate decarboxylase activity
EWA66_RS15145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EWA66_RS15150	COG4533	DNA binding
EWA66_RS15160	COG0561	phosphatase activity
EWA66_RS15175	COG0671	phosphoesterase, PA-phosphatase related
EWA66_RS15180	COG0351	phosphomethylpyrimidine kinase
EWA66_RS15245	COG0668	transmembrane transport
EWA66_RS15260	COG2239	Acts as a magnesium transporter
EWA66_RS15265	COG2207	Transcriptional regulator
EWA66_RS15280	COG0121	glutamine amidotransferase
EWA66_RS15285	COG0531	amino acid
EWA66_RS15310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EWA66_RS15315	COG0583	DNA-binding transcription factor activity
EWA66_RS15335	COG0534	Mate efflux family protein
EWA66_RS15340	COG2926	Belongs to the UPF0265 family
EWA66_RS15350	COG3132	Protein of unknown function, DUF480
EWA66_RS15355	COG2827	Endonuclease containing a URI domain
EWA66_RS15385	COG1522	sequence-specific DNA binding
EWA66_RS15400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWA66_RS15405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWA66_RS15415	COG0183	Belongs to the thiolase family
EWA66_RS15455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EWA66_RS15460	COG3850	Histidine kinase
EWA66_RS15465	COG2197	response regulator
EWA66_RS15475	COG2201	protein-glutamate methylesterase activity
EWA66_RS15485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EWA66_RS15485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EWA66_RS15495	COG0516	GMP reductase activity
EWA66_RS15500	COG0270	DNA (cytosine-5-)-methyltransferase activity
EWA66_RS15535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EWA66_RS15540	COG0697	spore germination
EWA66_RS15545	COG3437	response regulator, receiver
EWA66_RS15545	COG0784	Response regulator, receiver
EWA66_RS15555	COG3706	GGDEF domain
EWA66_RS15560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EWA66_RS15565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EWA66_RS15570	COG1845	cytochrome c oxidase, subunit III
EWA66_RS15575	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EWA66_RS15590	COG0456	acetyltransferase
EWA66_RS15595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EWA66_RS15600	COG0662	Cupin 2, conserved barrel domain protein
EWA66_RS15605	COG0527	aspartate kinase activity
EWA66_RS15620	COG0640	Transcriptional regulator
EWA66_RS15625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EWA66_RS15640	COG0418	dihydroorotase activity
EWA66_RS15645	COG0633	Ferredoxin
EWA66_RS15645	COG0633	Ferredoxin
EWA66_RS15645	COG3217	Mosc domain protein beta barrel domain protein
EWA66_RS15645	COG3217	Mosc domain protein beta barrel domain protein
EWA66_RS15650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EWA66_RS15655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EWA66_RS15690	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EWA66_RS15695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWA66_RS15705	COG0848	biopolymer transport protein
EWA66_RS15710	COG0811	peptide transport
EWA66_RS15715	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EWA66_RS15725	COG3721	Heme iron utilization protein
EWA66_RS15730	COG0748	coenzyme F420 binding
EWA66_RS15740	COG0784	Response regulator, receiver
EWA66_RS15740	COG0835	chemotaxis
EWA66_RS15745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EWA66_RS15750	COG0625	glutathione transferase activity
EWA66_RS15755	COG0366	Alpha amylase catalytic
EWA66_RS15770	COG3314	Sporulation integral membrane protein YlbJ
EWA66_RS15785	COG0739	heme binding
EWA66_RS15790	COG5001	Diguanylate cyclase
EWA66_RS15795	COG0583	DNA-binding transcription factor activity
EWA66_RS15800	COG2814	Major facilitator Superfamily
EWA66_RS15815	COG0697	spore germination
EWA66_RS15825	COG1764	response to oxidative stress
EWA66_RS15830	COG1846	Transcriptional regulator
EWA66_RS15855	COG1280	lysine exporter protein (LysE YggA)
EWA66_RS15865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EWA66_RS15875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EWA66_RS15880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EWA66_RS15895	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EWA66_RS15900	COG0513	Belongs to the DEAD box helicase family
EWA66_RS15905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EWA66_RS15915	COG1396	sequence-specific DNA binding
EWA66_RS15920	COG3135	benzoate transporter
EWA66_RS15930	COG2113	Glycine betaine
EWA66_RS15935	COG4176	ABC-type proline glycine betaine transport system permease component
EWA66_RS15945	COG1309	transcriptional regulator
EWA66_RS15950	COG1012	belongs to the aldehyde dehydrogenase family
EWA66_RS15970	COG4175	Glycine betaine
EWA66_RS15975	COG1858	cytochrome C peroxidase
EWA66_RS15985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EWA66_RS15990	COG5001	Diguanylate cyclase
EWA66_RS15990	COG1716	ATPase activity
EWA66_RS16010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EWA66_RS16015	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EWA66_RS16020	COG0247	lactate metabolic process
EWA66_RS16035	COG1619	proteins homologs of microcin C7 resistance protein MccF
EWA66_RS16040	COG2133	pyrroloquinoline quinone binding
EWA66_RS16045	COG1454	alcohol dehydrogenase
EWA66_RS16050	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EWA66_RS16070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EWA66_RS16075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EWA66_RS16080	COG3186	Phenylalanine-4-hydroxylase
EWA66_RS16085	COG2154	pterin-4-alpha-carbinolamine dehydratase
EWA66_RS16100	COG0814	amino acid
EWA66_RS16105	COG5002	protein histidine kinase activity
EWA66_RS16105	COG5001	Diguanylate cyclase
EWA66_RS16110	COG0312	modulator of DNA gyrase
EWA66_RS16115	COG0312	modulator of DNA gyrase
EWA66_RS16120	COG0584	glycerophosphoryl diester phosphodiesterase
EWA66_RS16125	COG2271	Major facilitator Superfamily
EWA66_RS16140	COG0840	transmembrane signaling receptor activity
EWA66_RS16145	COG0840	transmembrane signaling receptor activity
EWA66_RS16150	COG0456	acetyltransferase
EWA66_RS16160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EWA66_RS16170	COG4597	amino acid ABC transporter
EWA66_RS16175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA66_RS16185	COG1126	abc transporter atp-binding protein
EWA66_RS16195	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EWA66_RS16215	COG2315	Protein conserved in bacteria
EWA66_RS16230	COG1869	D-ribose catabolic process
EWA66_RS16235	COG1129	ABC transporter
EWA66_RS16240	COG1172	Belongs to the binding-protein-dependent transport system permease family
EWA66_RS16245	COG1879	ABC-type sugar transport system periplasmic component
EWA66_RS16250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA66_RS16255	COG1609	Transcriptional regulator
EWA66_RS16260	COG0784	Response regulator, receiver
EWA66_RS16260	COG0835	chemotaxis
EWA66_RS16300	COG0420	3'-5' exonuclease activity
EWA66_RS16305	COG0419	ATPase involved in DNA repair
EWA66_RS16320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EWA66_RS16320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EWA66_RS16325	COG0509	glycine decarboxylation via glycine cleavage system
EWA66_RS16330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EWA66_RS16340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EWA66_RS16355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWA66_RS16375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA66_RS16375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EWA66_RS16375	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EWA66_RS16380	COG1105	Belongs to the carbohydrate kinase PfkB family
EWA66_RS16385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA66_RS16385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWA66_RS16390	COG1609	Transcriptional regulator
EWA66_RS16410	COG1979	alcohol dehydrogenase
EWA66_RS16415	COG2207	Transcriptional regulator
EWA66_RS16430	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EWA66_RS16435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA66_RS16450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EWA66_RS16455	COG0840	transmembrane signaling receptor activity
EWA66_RS16465	COG0513	Belongs to the DEAD box helicase family
EWA66_RS16480	COG3038	cytochrome b561
EWA66_RS16485	COG2353	YceI-like domain
EWA66_RS16490	COG2116	formate transmembrane transporter activity
EWA66_RS16495	COG0583	DNA-binding transcription factor activity
EWA66_RS16505	COG3593	DNA synthesis involved in DNA repair
EWA66_RS16510	COG0737	Belongs to the 5'-nucleotidase family
EWA66_RS16515	COG0861	Integral membrane protein TerC family
EWA66_RS16535	COG2267	carboxylic ester hydrolase activity
EWA66_RS16545	COG0750	zinc metalloprotease
EWA66_RS16555	COG2050	protein possibly involved in aromatic compounds catabolism
EWA66_RS16565	COG4533	DNA binding
EWA66_RS16570	COG0366	Alpha amylase catalytic
EWA66_RS16580	COG1324	tolerance protein
EWA66_RS16595	COG0484	heat shock protein binding
EWA66_RS16605	COG1716	ATPase activity
EWA66_RS16605	COG5001	Diguanylate cyclase
EWA66_RS16610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EWA66_RS16620	COG4181	ATPase activity
EWA66_RS16625	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EWA66_RS16630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EWA66_RS16630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EWA66_RS16635	COG1984	allophanate hydrolase subunit 2
EWA66_RS16645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EWA66_RS16670	COG0583	DNA-binding transcription factor activity
EWA66_RS16675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA66_RS16675	COG0045	succinate-CoA ligase (ADP-forming) activity
EWA66_RS16675	COG1042	CoA-binding domain protein
EWA66_RS16700	COG0023	Translation Initiation Factor
EWA66_RS16705	COG2801	Transposase and inactivated derivatives
EWA66_RS16710	COG3140	Belongs to the UPF0181 family
EWA66_RS16725	COG0745	RESPONSE REGULATOR receiver
EWA66_RS16735	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EWA66_RS16740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EWA66_RS16760	COG3706	GGDEF domain
EWA66_RS16770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EWA66_RS16775	COG4149	molybdate abc transporter
EWA66_RS16780	COG0725	ABC transporter, periplasmic molybdate-binding protein
EWA66_RS16800	COG4067	protein conserved in archaea
EWA66_RS16800	COG0189	ligase activity
EWA66_RS16810	COG0602	queuosine metabolic process
EWA66_RS16815	COG1328	CTP reductase activity
EWA66_RS16860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EWA66_RS16865	COG3118	belongs to the thioredoxin family
EWA66_RS16900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EWA66_RS16915	COG0848	biopolymer transport protein
EWA66_RS16920	COG0811	peptide transport
EWA66_RS16925	COG0811	peptide transport
EWA66_RS17005	COG1271	oxidase subunit
EWA66_RS17010	COG1294	oxidase, subunit
EWA66_RS17045	COG5642	Protein of unknown function (DUF2384)
EWA66_RS17105	COG4964	Belongs to the GSP D family
EWA66_RS17125	COG0583	DNA-binding transcription factor activity
EWA66_RS17145	COG3097	Belongs to the UPF0267 family
EWA66_RS17155	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EWA66_RS17180	COG3069	C4-dicarboxylate transmembrane transporter activity
EWA66_RS17200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EWA66_RS17220	COG2198	Histidine kinase
EWA66_RS17220	COG0784	Response regulator, receiver
EWA66_RS17220	COG2205	protein histidine kinase activity
EWA66_RS17225	COG1879	ABC-type sugar transport system periplasmic component
EWA66_RS17230	COG1803	Methylglyoxal synthase
EWA66_RS17235	COG1803	Methylglyoxal synthase
EWA66_RS17240	COG0210	DNA helicase
EWA66_RS17245	COG1289	transmembrane transporter activity
EWA66_RS17265	COG1629	transport
EWA66_RS17265	COG4771	TonB-dependent receptor
EWA66_RS17270	COG3708	Transcriptional regulator
EWA66_RS17270	COG2207	Transcriptional regulator
EWA66_RS17275	COG0789	Transcriptional regulator
EWA66_RS17280	COG4604	ABC transporter, ATP-binding protein
EWA66_RS17285	COG4605	iron ion homeostasis
EWA66_RS17290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWA66_RS17295	COG4607	ABC-type enterochelin transport system periplasmic component
EWA66_RS17305	COG0659	secondary active sulfate transmembrane transporter activity
EWA66_RS17310	COG0589	response to stress
EWA66_RS17315	COG0513	Belongs to the DEAD box helicase family
EWA66_RS17320	COG1309	transcriptional regulator
EWA66_RS17325	COG2130	NADP-dependent
EWA66_RS17360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EWA66_RS17365	COG0583	DNA-binding transcription factor activity
EWA66_RS17370	COG0534	Mate efflux family protein
EWA66_RS17375	COG1472	Belongs to the glycosyl hydrolase 3 family
EWA66_RS17385	COG4580	involved in the transport of maltose and maltodextrins
EWA66_RS17415	COG4580	involved in the transport of maltose and maltodextrins
EWA66_RS17420	COG1609	Transcriptional regulator
EWA66_RS17430	COG4608	Belongs to the ABC transporter superfamily
EWA66_RS17435	COG0444	Belongs to the ABC transporter superfamily
EWA66_RS17440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWA66_RS17450	COG0747	negative chemotaxis
EWA66_RS17465	COG0583	DNA-binding transcription factor activity
EWA66_RS17475	COG3706	GGDEF domain
EWA66_RS17480	COG0840	transmembrane signaling receptor activity
EWA66_RS17490	COG3036	rescue of stalled ribosome
EWA66_RS17495	COG1278	Cold shock
EWA66_RS17525	COG0545	Peptidyl-prolyl cis-trans isomerase
EWA66_RS17530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EWA66_RS17540	COG0840	transmembrane signaling receptor activity
EWA66_RS17550	COG2195	Cleaves the N-terminal amino acid of tripeptides
EWA66_RS17560	COG4989	oxidoreductase activity
EWA66_RS17575	COG0038	chloride channel
EWA66_RS17585	COG0302	gtp cyclohydrolase
EWA66_RS17595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EWA66_RS17600	COG2897	thiosulfate sulfurtransferase activity
EWA66_RS17605	COG5001	Diguanylate cyclase
EWA66_RS17645	COG0840	transmembrane signaling receptor activity
EWA66_RS17660	COG3437	response regulator, receiver
EWA66_RS17660	COG3850	Histidine kinase
EWA66_RS17660	COG4999	Histidine kinase
EWA66_RS17660	COG2205	protein histidine kinase activity
EWA66_RS17675	COG3706	GGDEF domain
EWA66_RS17690	COG0513	Belongs to the DEAD box helicase family
EWA66_RS17695	COG0523	cobalamin synthesis protein
EWA66_RS17700	COG2384	SAM-dependent methyltransferase
EWA66_RS17705	COG1902	pentaerythritol trinitrate reductase activity
EWA66_RS17720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWA66_RS17725	COG3530	Putative quorum-sensing-regulated virulence factor
EWA66_RS17750	COG0443	Heat shock 70 kDa protein
EWA66_RS17765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA66_RS17765	COG4191	Histidine kinase
EWA66_RS17770	COG3437	response regulator, receiver
EWA66_RS17770	COG0784	Response regulator, receiver
EWA66_RS17780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EWA66_RS17815	COG0519	Catalyzes the synthesis of GMP from XMP
EWA66_RS17815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EWA66_RS17820	COG2076	Multidrug Resistance protein
EWA66_RS17825	COG0415	Belongs to the DNA photolyase family
EWA66_RS17830	COG0477	Major facilitator Superfamily
EWA66_RS17835	COG0583	DNA-binding transcription factor activity
EWA66_RS17855	COG1028	Short-chain dehydrogenase reductase Sdr
EWA66_RS17870	COG1024	Enoyl-CoA hydratase
EWA66_RS17875	COG1960	acyl-CoA dehydrogenase activity
EWA66_RS17885	COG0183	Belongs to the thiolase family
EWA66_RS17895	COG1960	acyl-CoA dehydrogenase activity
EWA66_RS17900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EWA66_RS17905	COG1024	Enoyl-CoA hydratase
EWA66_RS17920	COG0450	alkyl hydroperoxide reductase
EWA66_RS17925	COG3634	alkyl hydroperoxide reductase activity
EWA66_RS17930	COG3706	GGDEF domain
EWA66_RS17935	COG2354	Protein conserved in bacteria
EWA66_RS17965	COG3833	ABC-type maltose transport systems, permease component
EWA66_RS17970	COG1175	transmembrane transport
EWA66_RS17980	COG3842	ATPase activity
EWA66_RS17995	COG0714	Associated with various cellular activities
EWA66_RS18015	COG2304	oxidoreductase activity
EWA66_RS18025	COG3706	GGDEF domain
EWA66_RS18030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EWA66_RS18035	COG0581	inorganic phosphate transmembrane transporter activity
EWA66_RS18040	COG0573	inorganic phosphate transmembrane transporter activity
EWA66_RS18075	COG1770	oligopeptidase
EWA66_RS18080	COG0513	Belongs to the DEAD box helicase family
EWA66_RS18090	COG1376	ErfK ybiS ycfS ynhG family protein
EWA66_RS18090	COG1388	LysM domain
EWA66_RS18095	COG0415	Belongs to the DNA photolyase family
EWA66_RS18100	COG0789	Transcriptional regulator
EWA66_RS18105	COG3272	Protein of unknown function (DUF1722)
EWA66_RS18110	COG0813	purine-nucleoside phosphorylase activity
EWA66_RS18130	COG4720	Psort location CytoplasmicMembrane, score
EWA66_RS18135	COG1122	ATPase activity
EWA66_RS18145	COG0243	molybdopterin cofactor binding
EWA66_RS18150	COG0583	DNA-binding transcription factor activity
EWA66_RS18155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EWA66_RS18175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA66_RS18190	COG1067	ATP-dependent peptidase activity
EWA66_RS18200	COG4172	Belongs to the ABC transporter superfamily
EWA66_RS18210	COG0583	DNA-binding transcription factor activity
EWA66_RS18215	COG1620	l-lactate permease
EWA66_RS18220	COG1304	FMN binding
EWA66_RS18235	COG2814	Major facilitator Superfamily
EWA66_RS18270	COG3015	lipoprotein NlpE involved in copper resistance
EWA66_RS18275	COG1126	abc transporter atp-binding protein
EWA66_RS18280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA66_RS18285	COG4215	(ABC) transporter
EWA66_RS18290	COG4160	amino acid transport
EWA66_RS18305	COG0840	transmembrane signaling receptor activity
EWA66_RS18310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWA66_RS18330	COG0189	ligase activity
EWA66_RS18335	COG4067	protein conserved in archaea
EWA66_RS18335	COG0189	ligase activity
EWA66_RS18350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EWA66_RS18360	COG5002	protein histidine kinase activity
EWA66_RS18365	COG0745	RESPONSE REGULATOR receiver
EWA66_RS18385	COG0488	(ABC) transporter
EWA66_RS18400	COG1017	nitric oxide dioxygenase activity
EWA66_RS18400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EWA66_RS18405	COG0242	peptide deformylase activity
EWA66_RS18410	COG0589	response to stress
EWA66_RS18420	COG2111	Na H antiporter
EWA66_RS18420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EWA66_RS18425	COG1006	Multisubunit Na H antiporter MnhC subunit
EWA66_RS18430	COG0651	ATP synthesis coupled electron transport
EWA66_RS18435	COG1863	multisubunit Na H antiporter MnhE subunit
EWA66_RS18440	COG2212	antiporter activity
EWA66_RS18445	COG1320	monovalent cation:proton antiporter activity
EWA66_RS18450	COG1253	flavin adenine dinucleotide binding
EWA66_RS18455	COG1686	Belongs to the peptidase S11 family
EWA66_RS18465	COG1629	transport
EWA66_RS18480	COG1760	l-serine dehydratase
EWA66_RS18485	COG3104	oligopeptide transport
EWA66_RS18505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EWA66_RS18505	COG2207	Transcriptional regulator
EWA66_RS18510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EWA66_RS18520	COG1011	Hydrolase
EWA66_RS18545	COG1765	OsmC-like protein
EWA66_RS18550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWA66_RS18550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWA66_RS18555	COG3706	GGDEF domain
EWA66_RS18590	COG2188	Transcriptional regulator
EWA66_RS18610	COG3852	Histidine kinase
EWA66_RS18615	COG2200	EAL domain
EWA66_RS18615	COG2199	diguanylate cyclase activity
EWA66_RS18615	COG2202	Pas domain
EWA66_RS18625	COG4191	Histidine kinase
EWA66_RS18655	COG3842	ATPase activity
EWA66_RS18665	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EWA66_RS18670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EWA66_RS18675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EWA66_RS18680	COG2375	cellular response to nickel ion
EWA66_RS18685	COG0488	(ABC) transporter
EWA66_RS18715	COG1881	PFAM PEBP family protein
EWA66_RS18720	COG2207	Transcriptional regulator
EWA66_RS18730	COG3046	protein related to deoxyribodipyrimidine photolyase
EWA66_RS18755	COG2205	protein histidine kinase activity
EWA66_RS18760	COG1653	transport
EWA66_RS18765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWA66_RS18770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EWA66_RS18785	COG1342	Belongs to the UPF0251 family
EWA66_RS18810	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EWA66_RS18825	COG0583	DNA-binding transcription factor activity
EWA66_RS18865	COG1283	sodium-dependent phosphate transmembrane transporter activity
EWA66_RS18870	COG0625	glutathione transferase activity
EWA66_RS18880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EWA66_RS18890	COG3047	cAMP biosynthetic process
EWA66_RS18895	COG0579	oxidoreductase
EWA66_RS18920	COG1271	oxidase subunit
EWA66_RS18925	COG1294	oxidase, subunit
EWA66_RS18930	COG0625	glutathione transferase activity
EWA66_RS18935	COG0583	DNA-binding transcription factor activity
EWA66_RS18940	COG0640	Transcriptional regulator
EWA66_RS18945	COG0798	PFAM Bile acid sodium symporter
EWA66_RS18955	COG0697	spore germination
EWA66_RS18960	COG1263	PTS System
EWA66_RS18960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EWA66_RS18970	COG1621	beta-fructofuranosidase activity
EWA66_RS18975	COG3706	GGDEF domain
EWA66_RS18975	COG4251	negative regulation of phosphorylation
EWA66_RS18975	COG5001	Diguanylate cyclase
EWA66_RS18975	COG2203	Gaf domain
EWA66_RS18980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWA66_RS19030	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EWA66_RS19050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EWA66_RS19055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EWA66_RS19060	COG1640	4-alpha-glucanotransferase
EWA66_RS19065	COG0058	SHG alpha-glucan phosphorylase activity
EWA66_RS19070	COG2909	trisaccharide binding
EWA66_RS19110	COG0561	phosphatase activity
EWA66_RS19115	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EWA66_RS19120	COG3623	hexulose-6-phosphate isomerase
EWA66_RS19135	COG1132	(ABC) transporter
EWA66_RS19150	COG1523	belongs to the glycosyl hydrolase 13 family
EWA66_RS19185	COG5001	Diguanylate cyclase
EWA66_RS19200	COG3123	guanosine phosphorylase activity
EWA66_RS19235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EWA66_RS19245	COG1917	Cupin 2, conserved barrel domain protein
EWA66_RS19245	COG2169	Transcriptional regulator
EWA66_RS19280	COG0363	glucosamine-6-phosphate deaminase activity
EWA66_RS19290	COG0786	glutamate:sodium symporter activity
EWA66_RS19295	COG0786	glutamate:sodium symporter activity
EWA66_RS19305	COG3279	Response regulator of the LytR AlgR family
EWA66_RS19310	COG3275	phosphorelay sensor kinase activity
EWA66_RS19330	COG1136	(ABC) transporter
EWA66_RS19340	COG0217	transcriptional regulatory protein
EWA66_RS19360	COG3227	Zinc metalloprotease (Elastase)
EWA66_RS19380	COG1444	tRNA N-acetyltransferase activity
EWA66_RS19390	COG0215	cysteine-tRNA ligase activity
EWA66_RS19425	COG0259	pyridoxamine-phosphate oxidase activity
EWA66_RS19450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWA66_RS19470	COG1999	signal sequence binding
EWA66_RS19480	COG1162	GTPase activity
EWA66_RS19485	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EWA66_RS19515	COG3833	ABC-type maltose transport systems, permease component
EWA66_RS19520	COG1175	transmembrane transport
EWA66_RS19525	COG2182	Extracellular solute-binding protein
EWA66_RS19535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWA66_RS19545	COG3842	ATPase activity
EWA66_RS19570	COG1022	Amp-dependent synthetase and ligase
EWA66_RS19575	COG0537	adenosine 5'-monophosphoramidase activity
EWA66_RS19590	COG2084	Dehydrogenase
EWA66_RS19595	COG0730	response to heat
EWA66_RS19620	COG0840	transmembrane signaling receptor activity
EWA66_RS19630	COG0840	transmembrane signaling receptor activity
EWA66_RS19655	COG0784	Response regulator, receiver
EWA66_RS19655	COG5002	protein histidine kinase activity
EWA66_RS19655	COG2205	protein histidine kinase activity
EWA66_RS19660	COG0840	transmembrane signaling receptor activity
EWA66_RS19685	COG0513	Belongs to the DEAD box helicase family
EWA66_RS19740	COG0642	Histidine kinase
EWA66_RS19745	COG0564	pseudouridine synthase activity
EWA66_RS19755	COG3220	belongs to the UPF0276 family
EWA66_RS19770	COG5001	Diguanylate cyclase
EWA66_RS19770	COG3300	MHYT domain
EWA66_RS19775	COG3437	response regulator, receiver
EWA66_RS19795	COG1741	Belongs to the pirin family
EWA66_RS19800	COG2259	Doxx family
EWA66_RS19810	COG0366	Alpha amylase catalytic
EWA66_RS19815	COG1349	DNA-binding transcription factor activity
EWA66_RS19820	COG0673	inositol 2-dehydrogenase activity
EWA66_RS19825	COG4702	Belongs to the UPF0303 family
EWA66_RS19845	COG0625	glutathione transferase activity
EWA66_RS19855	COG3284	Transcriptional regulator
EWA66_RS19860	COG1012	belongs to the aldehyde dehydrogenase family
EWA66_RS19880	COG0513	Belongs to the DEAD box helicase family
EWA66_RS19915	COG0842	Transport permease protein
EWA66_RS19920	COG1131	(ABC) transporter
EWA66_RS19930	COG1737	Transcriptional regulator
EWA66_RS19940	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EWA66_RS19965	COG0251	oxidation-reduction process
EWA66_RS19970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EWA66_RS19975	COG2084	Dehydrogenase
EWA66_RS19985	COG2201	protein-glutamate methylesterase activity
EWA66_RS19990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EWA66_RS20005	COG0840	transmembrane signaling receptor activity
EWA66_RS20010	COG0835	chemotaxis
EWA66_RS20015	COG2198	Histidine kinase
EWA66_RS20015	COG0643	Histidine kinase
EWA66_RS20025	COG0745	RESPONSE REGULATOR receiver
EWA66_RS20045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EWA66_RS20055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EWA66_RS20070	COG0039	L-malate dehydrogenase activity
EWA66_RS20095	COG0393	Putative heavy-metal-binding
EWA66_RS20100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EWA66_RS20110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EWA66_RS20130	COG2211	Major facilitator Superfamily
EWA66_RS20145	COG3240	lipase activity
EWA66_RS20150	COG0156	8-amino-7-oxononanoate synthase activity
EWA66_RS20170	COG3385	transposase activity
EWA66_RS20190	COG0582	viral genome integration into host DNA
EWA66_RS20250	COG4626	Terminase
EWA66_RS20250	COG1802	Transcriptional regulator
EWA66_RS20270	COG1403	HNH endonuclease