locus-tag	class	description
D3H41_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3H41_RS00010	COG0592	DNA-directed DNA polymerase activity
D3H41_RS00020	COG0187	DNA topoisomerase II activity
D3H41_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
D3H41_RS00040	COG3977	Valine--pyruvate aminotransferase
D3H41_RS00045	COG0366	Alpha amylase catalytic
D3H41_RS00060	COG2119	membrane
D3H41_RS00070	COG0425	Belongs to the sulfur carrier protein TusA family
D3H41_RS00085	COG0604	alcohol dehydrogenase
D3H41_RS00090	COG0183	Belongs to the thiolase family
D3H41_RS00100	COG1739	Uncharacterized protein family UPF0029
D3H41_RS00105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3H41_RS00145	COG0583	DNA-binding transcription factor activity
D3H41_RS00150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D3H41_RS00155	COG2960	long-chain fatty acid transporting porin activity
D3H41_RS00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_RS00225	COG4166	transmembrane transport
D3H41_RS00230	COG0601	transmembrane transport
D3H41_RS00235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H41_RS00275	COG1609	Transcriptional regulator
D3H41_RS00280	COG0583	DNA-binding transcription factor activity
D3H41_RS00295	COG0129	dihydroxy-acid dehydratase activity
D3H41_RS00300	COG3265	gluconokinase activity
D3H41_RS00305	COG2610	gluconate transmembrane transporter activity
D3H41_RS00310	COG0800	Aldolase
D3H41_RS00315	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3H41_RS00320	COG0583	DNA-binding transcription factor activity
D3H41_RS00325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H41_RS00330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3H41_RS00340	COG1522	sequence-specific DNA binding
D3H41_RS00345	COG5001	Diguanylate cyclase
D3H41_RS00345	COG5002	protein histidine kinase activity
D3H41_RS00350	COG0742	ribosomal rna small subunit methyltransferase
D3H41_RS00365	COG0589	response to stress
D3H41_RS00370	COG1528	Iron-storage protein
D3H41_RS00380	COG2081	HI0933 family
D3H41_RS00410	COG1597	lipid kinase activity
D3H41_RS00440	COG0628	permease
D3H41_RS00455	COG1322	Protein conserved in bacteria
D3H41_RS00460	COG2226	methyltransferase
D3H41_RS00465	COG3165	ubiquinone biosynthetic process from chorismate
D3H41_RS00470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3H41_RS00480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3H41_RS00485	COG0805	protein transport
D3H41_RS00495	COG0084	hydrolase, TatD family'
D3H41_RS00510	COG0456	acetyltransferase
D3H41_RS00520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3H41_RS00520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3H41_RS00525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3H41_RS00560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3H41_RS00570	COG2204	response regulator
D3H41_RS00575	COG3852	Histidine kinase
D3H41_RS00585	COG0174	glutamine synthetase
D3H41_RS00590	COG1217	gtp-binding protein TYPA
D3H41_RS00595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3H41_RS00605	COG1295	ribonuclease BN
D3H41_RS00610	COG1490	D-aminoacyl-tRNA deacylase activity
D3H41_RS00615	COG0456	acetyltransferase
D3H41_RS00625	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D3H41_RS00630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D3H41_RS00635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3H41_RS00640	COG3031	protein transport across the cell outer membrane
D3H41_RS00650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3H41_RS00655	COG1459	type II secretion system
D3H41_RS00660	COG2165	general secretion pathway protein
D3H41_RS00665	COG2165	general secretion pathway protein
D3H41_RS00670	COG2165	general secretion pathway protein
D3H41_RS00675	COG4795	General secretion pathway protein
D3H41_RS00680	COG3156	type II secretion system protein K
D3H41_RS00685	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D3H41_RS00690	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D3H41_RS00700	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3H41_RS00705	COG0494	nUDIX hydrolase
D3H41_RS00715	COG1040	competence protein
D3H41_RS00730	COG2183	response to ionizing radiation
D3H41_RS00740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H41_RS00760	COG2233	PERMEase
D3H41_RS00765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3H41_RS00770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H41_RS00775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3H41_RS00780	COG1758	RNA polymerase activity
D3H41_RS00785	COG0194	GDP metabolic process
D3H41_RS00805	COG0848	biopolymer transport protein
D3H41_RS00810	COG0811	peptide transport
D3H41_RS00835	COG4174	ABC transporter (Permease)
D3H41_RS00840	COG4239	(ABC) transporter, permease
D3H41_RS00845	COG0747	negative chemotaxis
D3H41_RS00850	COG0444	Belongs to the ABC transporter superfamily
D3H41_RS00855	COG4608	Belongs to the ABC transporter superfamily
D3H41_RS00865	COG5001	Diguanylate cyclase
D3H41_RS00900	COG1561	YicC-like family, N-terminal region
D3H41_RS00910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3H41_RS00915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3H41_RS00920	COG1560	Kdo2-lipid A biosynthetic process
D3H41_RS00925	COG1309	transcriptional regulator
D3H41_RS00930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3H41_RS00940	COG0840	transmembrane signaling receptor activity
D3H41_RS00945	COG2003	Belongs to the UPF0758 family
D3H41_RS00970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3H41_RS00985	COG0463	Glycosyl transferase, family 2
D3H41_RS00990	COG0859	PFAM glycosyl transferase family 9
D3H41_RS00995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D3H41_RS01000	COG3642	lipopolysaccharide core region biosynthetic process
D3H41_RS01030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H41_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS01045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3H41_RS01060	COG1519	Transferase
D3H41_RS01065	COG0859	PFAM glycosyl transferase family 9
D3H41_RS01075	COG1560	Kdo2-lipid A biosynthetic process
D3H41_RS01085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3H41_RS01125	COG2089	acid synthase
D3H41_RS01140	COG2244	polysaccharide biosynthetic process
D3H41_RS01155	COG1215	transferase activity, transferring glycosyl groups
D3H41_RS01165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H41_RS01185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3H41_RS01190	COG0149	triose-phosphate isomerase activity
D3H41_RS01220	COG1494	fructose-1,6-bisphosphatase
D3H41_RS01230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3H41_RS01235	COG1575	Belongs to the MenA family. Type 1 subfamily
D3H41_RS01240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D3H41_RS01245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D3H41_RS01255	COG1609	Transcriptional regulator
D3H41_RS01260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3H41_RS01270	COG0254	rRNA binding
D3H41_RS01280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D3H41_RS01285	COG0088	Forms part of the polypeptide exit tunnel
D3H41_RS01295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3H41_RS01300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3H41_RS01305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3H41_RS01310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3H41_RS01320	COG0255	Belongs to the universal ribosomal protein uL29 family
D3H41_RS01325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3H41_RS01335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3H41_RS01340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D3H41_RS01350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3H41_RS01355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3H41_RS01370	COG1841	ribosomal large subunit assembly
D3H41_RS01375	COG0200	Binds to the 23S rRNA
D3H41_RS01380	COG0201	protein transport
D3H41_RS01385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3H41_RS01390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3H41_RS01395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D3H41_RS01405	COG0202	RNA polymerase activity
D3H41_RS01410	COG0203	ribosomal protein L17
D3H41_RS01420	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H41_RS01430	COG2153	protein acetylation
D3H41_RS01435	COG0513	Belongs to the DEAD box helicase family
D3H41_RS01450	COG1648	precorrin-2 dehydrogenase activity
D3H41_RS01450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3H41_RS01455	COG0175	sulfate reduction
D3H41_RS01460	COG2895	sulfate adenylyltransferase (ATP) activity
D3H41_RS01465	COG3273	potassium ion transport
D3H41_RS01465	COG0471	metal ion transport
D3H41_RS01470	COG0529	Catalyzes the synthesis of activated sulfate
D3H41_RS01490	COG4181	ATPase activity
D3H41_RS01505	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D3H41_RS01515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_RS01520	COG0729	surface antigen
D3H41_RS01525	COG2911	Protein conserved in bacteria
D3H41_RS01530	COG2105	PFAM AIG2 family protein
D3H41_RS01540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3H41_RS01545	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D3H41_RS01555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3H41_RS01560	COG0163	prenyltransferase activity
D3H41_RS01565	COG4143	(ABC) transporter
D3H41_RS01570	COG1178	ABC-type Fe3 transport system permease component
D3H41_RS01575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D3H41_RS01580	COG0583	DNA-binding transcription factor activity
D3H41_RS01585	COG1902	pentaerythritol trinitrate reductase activity
D3H41_RS01605	COG2358	TRAP transporter, solute receptor (TAXI family
D3H41_RS01630	COG0142	geranyltranstransferase activity
D3H41_RS01635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3H41_RS01645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3H41_RS01650	COG2966	Psort location CytoplasmicMembrane, score
D3H41_RS01665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3H41_RS01670	COG2967	ApaG domain
D3H41_RS01675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3H41_RS01680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3H41_RS01685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3H41_RS01690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3H41_RS01695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3H41_RS01715	COG0473	3-isopropylmalate dehydrogenase activity
D3H41_RS01720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3H41_RS01745	COG0583	DNA-binding transcription factor activity
D3H41_RS01750	COG1022	Amp-dependent synthetase and ligase
D3H41_RS01755	COG0028	Belongs to the TPP enzyme family
D3H41_RS01760	COG0440	acetolactate synthase activity
D3H41_RS01775	COG0469	pyruvate kinase activity
D3H41_RS01780	COG1349	DNA-binding transcription factor activity
D3H41_RS01785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3H41_RS01795	COG2376	Dihydroxyacetone kinase
D3H41_RS01800	COG1461	Dihydroxyacetone kinase
D3H41_RS01815	COG3722	fumarate hydratase activity
D3H41_RS01825	COG2213	PTS system mannitol-specific
D3H41_RS01825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_RS01865	COG0358	DNA primase activity
D3H41_RS01870	COG1610	YqeY-like protein
D3H41_RS01875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3H41_RS01880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3H41_RS01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3H41_RS01890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D3H41_RS01895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3H41_RS01900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3H41_RS01905	COG1968	undecaprenyl-diphosphatase activity
D3H41_RS01915	COG3267	Type II secretory pathway component ExeA
D3H41_RS01915	COG3409	Peptidoglycan-binding domain 1 protein
D3H41_RS01925	COG0405	Gamma-glutamyltransferase
D3H41_RS01930	COG4991	sh3 domain protein
D3H41_RS01935	COG0306	phosphate transporter
D3H41_RS01940	COG1392	Phosphate transport regulator
D3H41_RS01945	COG3025	triphosphatase activity
D3H41_RS01960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3H41_RS01965	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3H41_RS01965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3H41_RS01970	COG1538	Outer membrane efflux protein
D3H41_RS01975	COG0494	nUDIX hydrolase
D3H41_RS01980	COG3151	Protein conserved in bacteria
D3H41_RS01990	COG3150	esterase
D3H41_RS02000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3H41_RS02005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3H41_RS02015	COG3105	Protein conserved in bacteria
D3H41_RS02025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3H41_RS02040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3H41_RS02045	COG0723	plastoquinol--plastocyanin reductase activity
D3H41_RS02050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3H41_RS02055	COG2857	Cytochrome c1
D3H41_RS02060	COG0625	glutathione transferase activity
D3H41_RS02065	COG2969	positive regulation of protein catabolic process
D3H41_RS02070	COG2823	Periplasmic or secreted lipoprotein
D3H41_RS02075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3H41_RS02090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3H41_RS02110	COG3116	cell division
D3H41_RS02115	COG0768	penicillin binding
D3H41_RS02120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3H41_RS02125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D3H41_RS02130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3H41_RS02135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D3H41_RS02140	COG0772	Belongs to the SEDS family
D3H41_RS02155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3H41_RS02160	COG0849	cell division
D3H41_RS02165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3H41_RS02170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D3H41_RS02180	COG0653	protein targeting
D3H41_RS02185	COG0494	nUDIX hydrolase
D3H41_RS02195	COG0505	Belongs to the CarA family
D3H41_RS02200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3H41_RS02215	COG0730	response to heat
D3H41_RS02220	COG0583	DNA-binding transcription factor activity
D3H41_RS02225	COG2860	membrane
D3H41_RS02240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3H41_RS02250	COG0493	'glutamate synthase
D3H41_RS02255	COG0069	glutamate synthase activity
D3H41_RS02255	COG0070	glutamate synthase
D3H41_RS02255	COG0067	glutamate synthase
D3H41_RS02265	COG0069	glutamate synthase activity
D3H41_RS02265	COG0067	glutamate synthase
D3H41_RS02265	COG0070	glutamate synthase
D3H41_RS02270	COG1242	4 iron, 4 sulfur cluster binding
D3H41_RS02275	COG2203	Gaf domain
D3H41_RS02275	COG3706	GGDEF domain
D3H41_RS02275	COG4251	negative regulation of phosphorylation
D3H41_RS02275	COG5001	Diguanylate cyclase
D3H41_RS02280	COG0784	Response regulator, receiver
D3H41_RS02280	COG2198	Histidine kinase
D3H41_RS02280	COG5002	protein histidine kinase activity
D3H41_RS02290	COG0745	RESPONSE REGULATOR receiver
D3H41_RS02305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3H41_RS02325	COG0083	homoserine kinase activity
D3H41_RS02330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3H41_RS02340	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D3H41_RS02345	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D3H41_RS02355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D3H41_RS02370	COG1115	amino acid carrier protein
D3H41_RS02375	COG3022	response to hydroperoxide
D3H41_RS02380	COG0513	Belongs to the DEAD box helicase family
D3H41_RS02385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D3H41_RS02395	COG0716	FMN binding
D3H41_RS02400	COG4974	Belongs to the 'phage' integrase family
D3H41_RS02405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3H41_RS02410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3H41_RS02425	COG2204	response regulator
D3H41_RS02435	COG0667	Aldo Keto reductase
D3H41_RS02460	COG0730	response to heat
D3H41_RS02465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D3H41_RS02470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D3H41_RS02480	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3H41_RS02485	COG0583	DNA-binding transcription factor activity
D3H41_RS02490	COG0640	Transcriptional regulator
D3H41_RS02495	COG0268	Binds directly to 16S ribosomal RNA
D3H41_RS02500	COG0728	peptidoglycan biosynthetic process
D3H41_RS02505	COG0196	riboflavin kinase activity
D3H41_RS02520	COG1047	Peptidyl-prolyl cis-trans
D3H41_RS02525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3H41_RS02535	COG3279	Response regulator of the LytR AlgR family
D3H41_RS02540	COG3275	phosphorelay sensor kinase activity
D3H41_RS02545	COG1966	Carbon starvation protein
D3H41_RS02565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3H41_RS02570	COG1472	Belongs to the glycosyl hydrolase 3 family
D3H41_RS02575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3H41_RS02580	COG0287	Prephenate dehydrogenase
D3H41_RS02580	COG1605	Chorismate mutase
D3H41_RS02585	COG0739	heme binding
D3H41_RS02595	COG0488	(ABC) transporter
D3H41_RS02605	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
D3H41_RS02610	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D3H41_RS02615	COG1605	Chorismate mutase
D3H41_RS02615	COG0077	Prephenate dehydratase
D3H41_RS02620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3H41_RS02625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D3H41_RS02630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3H41_RS02635	COG0564	pseudouridine synthase activity
D3H41_RS02645	COG0542	response to heat
D3H41_RS02705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3H41_RS02710	COG0826	peptidase U32
D3H41_RS02715	COG2974	May be involved in recombination
D3H41_RS02725	COG0745	RESPONSE REGULATOR receiver
D3H41_RS02730	COG5002	protein histidine kinase activity
D3H41_RS02745	COG0248	Ppx GppA phosphatase
D3H41_RS02750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3H41_RS02755	COG0573	inorganic phosphate transmembrane transporter activity
D3H41_RS02760	COG0581	inorganic phosphate transmembrane transporter activity
D3H41_RS02765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3H41_RS02770	COG0704	Plays a role in the regulation of phosphate uptake
D3H41_RS02780	COG3142	Participates in the control of copper homeostasis
D3H41_RS02790	COG0450	alkyl hydroperoxide reductase
D3H41_RS02795	COG0583	DNA-binding transcription factor activity
D3H41_RS02800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3H41_RS02810	COG0517	IMP dehydrogenase activity
D3H41_RS02820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3H41_RS02830	COG1862	Preprotein translocase
D3H41_RS02835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H41_RS02840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H41_RS02855	COG0483	inositol monophosphate 1-phosphatase activity
D3H41_RS02860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D3H41_RS02870	COG1104	cysteine desulfurase activity
D3H41_RS02875	COG0822	iron-sulfur transferase activity
D3H41_RS02890	COG0443	Heat shock 70 kDa protein
D3H41_RS02895	COG0633	Ferredoxin
D3H41_RS02900	COG2975	iron-sulfur cluster assembly
D3H41_RS02910	COG0105	UTP biosynthetic process
D3H41_RS02925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3H41_RS02930	COG0124	histidyl-tRNA synthetase
D3H41_RS02935	COG2976	Protein conserved in bacteria
D3H41_RS02940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3H41_RS02945	COG1160	GTP binding
D3H41_RS02965	COG0517	IMP dehydrogenase activity
D3H41_RS02965	COG0516	GMP reductase activity
D3H41_RS02970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3H41_RS02970	COG0519	Catalyzes the synthesis of GMP from XMP
D3H41_RS02975	COG0582	viral genome integration into host DNA
D3H41_RS03135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H41_RS03150	COG1757	Na H antiporter
D3H41_RS03160	COG1584	GPR1 FUN34 yaaH family protein
D3H41_RS03165	COG1115	amino acid carrier protein
D3H41_RS03180	COG2873	o-acetylhomoserine
D3H41_RS03185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3H41_RS03205	COG3153	acetyltransferase
D3H41_RS03205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3H41_RS03210	COG0583	DNA-binding transcription factor activity
D3H41_RS03235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3H41_RS03240	COG2867	negative regulation of translational initiation
D3H41_RS03245	COG2914	Belongs to the UPF0125 (RnfH) family
D3H41_RS03250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3H41_RS03260	COG0497	DNA recombination
D3H41_RS03270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D3H41_RS03275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3H41_RS03280	COG1301	dicarboxylic acid transport
D3H41_RS03290	COG0484	heat shock protein binding
D3H41_RS03320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D3H41_RS03335	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D3H41_RS03340	COG0047	phosphoribosylformylglycinamidine synthase activity
D3H41_RS03340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3H41_RS03355	COG1629	transport
D3H41_RS03370	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3H41_RS03375	COG2252	PERMEase
D3H41_RS03380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3H41_RS03385	COG1073	alpha beta
D3H41_RS03395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D3H41_RS03400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3H41_RS03405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3H41_RS03410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3H41_RS03410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3H41_RS03425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3H41_RS03435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3H41_RS03440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D3H41_RS03445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3H41_RS03450	COG0142	geranyltranstransferase activity
D3H41_RS03455	COG1722	exodeoxyribonuclease VII activity
D3H41_RS03460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3H41_RS03470	COG0301	tRNA thio-modification
D3H41_RS03470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H41_RS03475	COG0583	DNA-binding transcription factor activity
D3H41_RS03485	COG2363	Small membrane protein
D3H41_RS03495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3H41_RS03500	COG1611	Belongs to the LOG family
D3H41_RS03515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3H41_RS03515	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3H41_RS03525	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D3H41_RS03530	COG1464	Belongs to the NlpA lipoprotein family
D3H41_RS03535	COG2011	ABC-type metal ion transport system permease component
D3H41_RS03540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3H41_RS03545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3H41_RS03555	COG1263	PTS System
D3H41_RS03555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_RS03560	COG0366	Alpha amylase catalytic
D3H41_RS03575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D3H41_RS03580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3H41_RS03585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3H41_RS03590	COG0321	lipoyl(octanoyl) transferase activity
D3H41_RS03600	COG1686	Belongs to the peptidase S11 family
D3H41_RS03605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3H41_RS03610	COG0772	Belongs to the SEDS family
D3H41_RS03615	COG0768	penicillin binding
D3H41_RS03620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3H41_RS03625	COG0799	negative regulation of ribosome biogenesis
D3H41_RS03630	COG1466	dna polymerase III delta subunit
D3H41_RS03635	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D3H41_RS03640	COG0495	leucyl-tRNA aminoacylation
D3H41_RS03645	COG2888	peptidyl-tyrosine sulfation
D3H41_RS03650	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3H41_RS03655	COG4535	Mg2 and Co2 transporter CorC
D3H41_RS03660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3H41_RS03665	COG1702	phosphate starvation-inducible protein PhoH
D3H41_RS03670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3H41_RS03680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3H41_RS03790	COG0012	GTP binding
D3H41_RS03795	COG0193	aminoacyl-tRNA hydrolase activity
D3H41_RS03800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3H41_RS03805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3H41_RS03810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D3H41_RS03815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3H41_RS03825	COG2890	protein-(glutamine-N5) methyltransferase activity
D3H41_RS03830	COG3094	Invasion gene expression up-regulator, SirB
D3H41_RS03835	COG2912	Transglutaminase-like superfamily
D3H41_RS03840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D3H41_RS03845	COG0737	Belongs to the 5'-nucleotidase family
D3H41_RS03850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3H41_RS03855	COG1187	pseudouridine synthase activity
D3H41_RS03860	COG2840	Smr protein MutS2
D3H41_RS03900	COG2608	mercury ion transmembrane transporter activity
D3H41_RS03900	COG2217	Heavy metal translocating P-type atpase
D3H41_RS03920	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D3H41_RS03975	COG0784	Response regulator, receiver
D3H41_RS03975	COG0835	chemotaxis
D3H41_RS03980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3H41_RS03985	COG1815	bacterial-type flagellum-dependent cell motility
D3H41_RS03990	COG1558	bacterial-type flagellum-dependent cell motility
D3H41_RS04000	COG1749	Flagellar hook protein flgE
D3H41_RS04005	COG4787	bacterial-type flagellum-dependent cell motility
D3H41_RS04015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3H41_RS04020	COG1706	bacterial-type flagellum-dependent cell motility
D3H41_RS04025	COG3951	Flagellar rod assembly protein muramidase FlgJ
D3H41_RS04025	COG1705	Flagellar rod assembly protein muramidase FlgJ
D3H41_RS04035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_RS04040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_RS04050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_RS04055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_RS04065	COG2190	(PTS) system
D3H41_RS04070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3H41_RS04075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_RS04085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3H41_RS04090	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D3H41_RS04095	COG3115	cell septum assembly
D3H41_RS04100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3H41_RS04125	COG0330	HflC and HflK could
D3H41_RS04130	COG3118	belongs to the thioredoxin family
D3H41_RS04140	COG0300	oxidoreductase activity
D3H41_RS04145	COG1090	epimerase
D3H41_RS04175	COG0622	Phosphoesterase
D3H41_RS04195	COG3710	Transcriptional regulator
D3H41_RS04200	COG0326	Molecular chaperone. Has ATPase activity
D3H41_RS04210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3H41_RS04215	COG3104	oligopeptide transport
D3H41_RS04220	COG0250	Participates in transcription elongation, termination and antitermination
D3H41_RS04225	COG0367	asparagine synthase
D3H41_RS04230	COG4651	solute:proton antiporter activity
D3H41_RS04230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3H41_RS04235	COG1846	Transcriptional regulator
D3H41_RS04235	COG1940	carbohydrate kinase activity
D3H41_RS04240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3H41_RS04250	COG2190	(PTS) system
D3H41_RS04250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_RS04250	COG1263	PTS System
D3H41_RS04255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3H41_RS04260	COG0735	belongs to the Fur family
D3H41_RS04270	COG0716	FMN binding
D3H41_RS04280	COG0596	Alpha beta hydrolase
D3H41_RS04285	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D3H41_RS04290	COG0033	Phosphoglucomutase
D3H41_RS04300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D3H41_RS04315	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D3H41_RS04320	COG1053	succinate dehydrogenase
D3H41_RS04325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3H41_RS04330	COG0567	Dehydrogenase, E1 component
D3H41_RS04335	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3H41_RS04340	COG0045	succinate-CoA ligase (ADP-forming) activity
D3H41_RS04350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3H41_RS04355	COG1121	(ABC) transporter
D3H41_RS04360	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D3H41_RS04365	COG4977	sequence-specific DNA binding
D3H41_RS04370	COG1918	ferrous iron import across plasma membrane
D3H41_RS04395	COG0018	arginyl-trna synthetase
D3H41_RS04405	COG3102	Protein conserved in bacteria
D3H41_RS04420	COG0788	formyltetrahydrofolate deformylase activity
D3H41_RS04425	COG1199	ATP-dependent helicase activity
D3H41_RS04430	COG1214	PFAM Peptidase M22, glycoprotease
D3H41_RS04440	COG3065	identical protein binding
D3H41_RS04445	COG2267	carboxylic ester hydrolase activity
D3H41_RS04450	COG0318	PFAM AMP-dependent synthetase and ligase
D3H41_RS04455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3H41_RS04460	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D3H41_RS04465	COG2894	cell division
D3H41_RS04470	COG0850	regulation of cytokinetic process
D3H41_RS04475	COG3100	YcgL domain-containing protein
D3H41_RS04480	COG2951	lytic endotransglycosylase activity
D3H41_RS04490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3H41_RS04495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3H41_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS04520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3H41_RS04545	COG2986	histidine ammonia-lyase
D3H41_RS04550	COG1216	Glycosyl transferase, family 2
D3H41_RS04555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3H41_RS04570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3H41_RS04575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3H41_RS04610	COG0513	Belongs to the DEAD box helicase family
D3H41_RS04615	COG0569	domain protein
D3H41_RS04620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3H41_RS04635	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D3H41_RS04640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3H41_RS04645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3H41_RS04650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3H41_RS04675	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3H41_RS04685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D3H41_RS04690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3H41_RS04695	COG0776	regulation of translation
D3H41_RS04700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3H41_RS04705	COG1555	photosystem II stabilization
D3H41_RS04720	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3H41_RS04725	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D3H41_RS04730	COG0436	Aminotransferase
D3H41_RS04735	COG1169	isochorismate synthase
D3H41_RS04740	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D3H41_RS04750	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3H41_RS04770	COG2855	membrane
D3H41_RS04775	COG0477	Major facilitator Superfamily
D3H41_RS04820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_RS04825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_RS04845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3H41_RS04850	COG1522	sequence-specific DNA binding
D3H41_RS04860	COG1946	Acyl-CoA thioesterase
D3H41_RS04865	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D3H41_RS04890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H41_RS04895	COG0517	IMP dehydrogenase activity
D3H41_RS04895	COG0516	GMP reductase activity
D3H41_RS04920	COG0537	adenosine 5'-monophosphoramidase activity
D3H41_RS04945	COG3150	esterase
D3H41_RS04950	COG1252	NADH dehydrogenase
D3H41_RS04965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3H41_RS04975	COG4591	ABC-type transport system involved in lipoprotein release permease component
D3H41_RS04980	COG1136	(ABC) transporter
D3H41_RS04985	COG4591	ABC-type transport system involved in lipoprotein release permease component
D3H41_RS04995	COG0658	competence protein
D3H41_RS04995	COG2333	competence protein COMEC
D3H41_RS05005	COG1132	(ABC) transporter
D3H41_RS05025	COG2719	SpoVR family
D3H41_RS05030	COG2718	Belongs to the UPF0229 family
D3H41_RS05035	COG2766	serine protein kinase
D3H41_RS05045	COG3013	Belongs to the UPF0304 family
D3H41_RS05055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3H41_RS05065	COG1882	Formate acetyltransferase
D3H41_RS05110	COG0708	Exodeoxyribonuclease III
D3H41_RS05120	COG3923	Primosomal replication protein n
D3H41_RS05125	COG0730	response to heat
D3H41_RS05130	COG1199	ATP-dependent helicase activity
D3H41_RS05135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3H41_RS05140	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D3H41_RS05145	COG1187	pseudouridine synthase activity
D3H41_RS05155	COG1278	Cold shock
D3H41_RS05160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3H41_RS05165	COG0542	response to heat
D3H41_RS05170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3H41_RS05175	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D3H41_RS05180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D3H41_RS05200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3H41_RS05205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3H41_RS05210	COG0297	glycogen (starch) synthase activity
D3H41_RS05230	COG3070	regulator of competence-specific genes
D3H41_RS05235	COG1609	Transcriptional regulator
D3H41_RS05240	COG3381	protein complex oligomerization
D3H41_RS05245	COG0745	RESPONSE REGULATOR receiver
D3H41_RS05250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D3H41_RS05255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H41_RS05260	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D3H41_RS05265	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D3H41_RS05270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3H41_RS05290	COG0189	ligase activity
D3H41_RS05290	COG4067	protein conserved in archaea
D3H41_RS05300	COG0500	methyltransferase
D3H41_RS05310	COG1801	Protein of unknown function DUF72
D3H41_RS05320	COG0217	transcriptional regulatory protein
D3H41_RS05325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D3H41_RS05330	COG0632	four-way junction helicase activity
D3H41_RS05335	COG2255	four-way junction helicase activity
D3H41_RS05340	COG1271	oxidase subunit
D3H41_RS05345	COG1294	oxidase, subunit
D3H41_RS05350	COG4890	Cyd operon protein YbgT
D3H41_RS05360	COG0824	Thioesterase
D3H41_RS05365	COG0811	peptide transport
D3H41_RS05380	COG0823	Involved in the tonB-independent uptake of proteins
D3H41_RS05385	COG2885	chlorophyll binding
D3H41_RS05390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D3H41_RS05395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D3H41_RS05405	COG3766	membrane
D3H41_RS05415	COG0754	glutathionylspermidine amidase activity
D3H41_RS05425	COG0784	Response regulator, receiver
D3H41_RS05425	COG5002	protein histidine kinase activity
D3H41_RS05455	COG0328	RNA-DNA hybrid ribonuclease activity
D3H41_RS05470	COG1294	oxidase, subunit
D3H41_RS05475	COG1271	oxidase subunit
D3H41_RS05495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_RS05500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_RS05525	COG3568	Endonuclease Exonuclease Phosphatase
D3H41_RS05550	COG0583	DNA-binding transcription factor activity
D3H41_RS05560	COG0686	Belongs to the AlaDH PNT family
D3H41_RS05570	COG1674	ftsk spoiiie
D3H41_RS05580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3H41_RS05600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3H41_RS05625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3H41_RS05645	COG0300	oxidoreductase activity
D3H41_RS05660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3H41_RS05670	COG2268	Band 7 protein
D3H41_RS05680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3H41_RS05685	COG2915	High frequency lysogenization protein hflD homolog
D3H41_RS05700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_RS05710	COG1757	Na H antiporter
D3H41_RS05725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3H41_RS05735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3H41_RS05735	COG0131	Imidazoleglycerol-phosphate dehydratase
D3H41_RS05740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D3H41_RS05745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D3H41_RS05755	COG0140	phosphoribosyl-ATP diphosphatase activity
D3H41_RS05755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3H41_RS05760	COG3012	SEC-C Motif Domain Protein
D3H41_RS05765	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D3H41_RS05770	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H41_RS05775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3H41_RS05780	COG0215	cysteine-tRNA ligase activity
D3H41_RS05785	COG1435	thymidine kinase activity
D3H41_RS05790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D3H41_RS05815	COG2116	formate transmembrane transporter activity
D3H41_RS05825	COG0390	transport system, permease component
D3H41_RS05830	COG4459	periplasmic nitrate reductase
D3H41_RS05835	COG3005	denitrification pathway
D3H41_RS05840	COG0243	molybdopterin cofactor binding
D3H41_RS05855	COG1227	inorganic diphosphatase activity
D3H41_RS05865	COG4172	Belongs to the ABC transporter superfamily
D3H41_RS05875	COG4171	peptide transport system, permease
D3H41_RS05890	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D3H41_RS05895	COG1842	Phage shock protein A
D3H41_RS05905	COG1983	PspC domain protein
D3H41_RS05925	COG2818	Glycosylase
D3H41_RS05930	COG5380	lipid catabolic process
D3H41_RS05935	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D3H41_RS05940	COG0626	cystathionine gamma-synthase activity
D3H41_RS05950	COG0733	neurotransmitter:sodium symporter activity
D3H41_RS05955	COG0564	pseudouridine synthase activity
D3H41_RS05965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3H41_RS05970	COG1151	hydroxylamine reductase activity
D3H41_RS05975	COG3604	Transcriptional regulator
D3H41_RS05990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3H41_RS05995	COG4136	ATPase activity
D3H41_RS06000	COG4135	transport system, permease component
D3H41_RS06005	COG4134	Bacterial extracellular solute-binding protein
D3H41_RS06015	COG3313	Fe-S protein
D3H41_RS06040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3H41_RS06060	COG1061	Type III restriction enzyme res subunit
D3H41_RS06065	COG1187	pseudouridine synthase activity
D3H41_RS06075	COG2814	Major facilitator Superfamily
D3H41_RS06085	COG0702	epimerase
D3H41_RS06090	COG0534	Mate efflux family protein
D3H41_RS06110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H41_RS06120	COG1960	acyl-CoA dehydrogenase activity
D3H41_RS06125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3H41_RS06130	COG2985	domain, Protein
D3H41_RS06130	COG3273	potassium ion transport
D3H41_RS06135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3H41_RS06150	COG1737	Transcriptional regulator
D3H41_RS06155	COG0076	glutamate decarboxylase activity
D3H41_RS06165	COG2431	L-lysine efflux transmembrane transporter activity
D3H41_RS06185	COG3070	regulator of competence-specific genes
D3H41_RS06200	COG4191	Histidine kinase
D3H41_RS06200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_RS06210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D3H41_RS06220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D3H41_RS06225	COG4988	ABC transporter
D3H41_RS06230	COG0492	ferredoxin-NADP+ reductase activity
D3H41_RS06255	COG0471	metal ion transport
D3H41_RS06260	COG2949	membrane
D3H41_RS06265	COG0281	malic enzyme
D3H41_RS06270	COG1643	Atp-dependent helicase
D3H41_RS06285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3H41_RS06320	COG0277	FAD linked oxidase domain protein
D3H41_RS06320	COG0247	lactate metabolic process
D3H41_RS06335	COG2986	histidine ammonia-lyase
D3H41_RS06340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3H41_RS06345	COG0010	Belongs to the arginase family
D3H41_RS06350	COG1228	amidohydrolase
D3H41_RS06355	COG2188	Transcriptional regulator
D3H41_RS06370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3H41_RS06380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3H41_RS06390	COG0393	Putative heavy-metal-binding
D3H41_RS06425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3H41_RS06430	COG0072	phenylalanine-tRNA ligase activity
D3H41_RS06430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H41_RS06440	COG0776	regulation of translation
D3H41_RS06450	COG0500	methyltransferase
D3H41_RS06455	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3H41_RS06465	COG0295	cytidine deaminase activity
D3H41_RS06470	COG1346	cytolysis
D3H41_RS06475	COG1380	Effector of murein hydrolase LrgA
D3H41_RS06480	COG2925	Exonuclease
D3H41_RS06485	COG1823	symporter activity
D3H41_RS06490	COG0702	epimerase
D3H41_RS06495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D3H41_RS06500	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3H41_RS06520	COG2988	succinylglutamate desuccinylase activity
D3H41_RS06525	COG4139	cobalamin transport
D3H41_RS06530	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
D3H41_RS06550	COG0583	DNA-binding transcription factor activity
D3H41_RS06560	COG1451	nucleotide metabolic process
D3H41_RS06565	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D3H41_RS06595	COG3938	Belongs to the proline racemase family
D3H41_RS06610	COG2423	ornithine cyclodeaminase activity
D3H41_RS06615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H41_RS06620	COG3842	ATPase activity
D3H41_RS06625	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3H41_RS06630	COG1177	transmembrane transport
D3H41_RS06640	COG3291	Pkd domain containing protein
D3H41_RS06660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H41_RS06665	COG0601	transmembrane transport
D3H41_RS06675	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3H41_RS06685	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D3H41_RS06695	COG0625	glutathione transferase activity
D3H41_RS06745	COG3755	Protein conserved in bacteria
D3H41_RS06770	COG1742	UPF0060 membrane protein
D3H41_RS06785	COG1757	Na H antiporter
D3H41_RS06790	COG0174	glutamine synthetase
D3H41_RS06800	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3H41_RS06805	COG1917	Cupin 2, conserved barrel domain protein
D3H41_RS06805	COG1396	sequence-specific DNA binding
D3H41_RS06810	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_RS06815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H41_RS06825	COG2957	Belongs to the agmatine deiminase family
D3H41_RS06830	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_RS06835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3H41_RS06840	COG2200	EAL domain
D3H41_RS06850	COG1846	Transcriptional regulator
D3H41_RS06855	COG2315	Protein conserved in bacteria
D3H41_RS06895	COG3063	Type IV pilus biogenesis stability protein PilW
D3H41_RS06900	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D3H41_RS06915	COG1560	Kdo2-lipid A biosynthetic process
D3H41_RS06920	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D3H41_RS06925	COG1280	lysine exporter protein (LysE YggA)
D3H41_RS06935	COG1115	amino acid carrier protein
D3H41_RS06960	COG1368	sulfuric ester hydrolase activity
D3H41_RS06965	COG2113	Glycine betaine
D3H41_RS06970	COG4176	ABC-type proline glycine betaine transport system permease component
D3H41_RS06975	COG4175	Glycine betaine
D3H41_RS06990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_RS07000	COG0456	acetyltransferase
D3H41_RS07005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3H41_RS07010	COG0662	Cupin 2, conserved barrel domain protein
D3H41_RS07015	COG0527	aspartate kinase activity
D3H41_RS07020	COG3119	arylsulfatase activity
D3H41_RS07035	COG0641	radical SAM
D3H41_RS07050	COG3119	arylsulfatase activity
D3H41_RS07075	COG1538	Outer membrane efflux protein
D3H41_RS07090	COG1349	DNA-binding transcription factor activity
D3H41_RS07095	COG0673	inositol 2-dehydrogenase activity
D3H41_RS07100	COG4702	Belongs to the UPF0303 family
D3H41_RS07125	COG0471	metal ion transport
D3H41_RS07140	COG3300	MHYT domain
D3H41_RS07140	COG5001	Diguanylate cyclase
D3H41_RS07155	COG1328	CTP reductase activity
D3H41_RS07160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3H41_RS07170	COG0861	Integral membrane protein TerC family
D3H41_RS07180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D3H41_RS07190	COG0814	amino acid
D3H41_RS07205	COG1120	ATPase activity
D3H41_RS07210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3H41_RS07220	COG4774	siderophore transport
D3H41_RS07230	COG1132	(ABC) transporter
D3H41_RS07235	COG1132	(ABC) transporter
D3H41_RS07250	COG0583	DNA-binding transcription factor activity
D3H41_RS07275	COG0443	Heat shock 70 kDa protein
D3H41_RS07280	COG0443	Heat shock 70 kDa protein
D3H41_RS07325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3H41_RS07330	COG1643	Atp-dependent helicase
D3H41_RS07345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_RS07355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H41_RS07360	COG1215	transferase activity, transferring glycosyl groups
D3H41_RS07365	COG0438	transferase activity, transferring glycosyl groups
D3H41_RS07395	COG0438	transferase activity, transferring glycosyl groups
D3H41_RS07400	COG0297	glycogen (starch) synthase activity
D3H41_RS07405	COG2204	response regulator
D3H41_RS07435	COG1793	dna ligase
D3H41_RS07445	COG0534	Mate efflux family protein
D3H41_RS07450	COG0307	riboflavin synthase, alpha
D3H41_RS07460	COG3001	Fructosamine kinase
D3H41_RS07470	COG3706	GGDEF domain
D3H41_RS07480	COG0791	NLP P60 protein
D3H41_RS07510	COG3148	PFAM DTW domain containing protein
D3H41_RS07515	COG1940	carbohydrate kinase activity
D3H41_RS07530	COG0746	molybdenum cofactor guanylyltransferase activity
D3H41_RS07535	COG3842	ATPase activity
D3H41_RS07550	COG2204	response regulator
D3H41_RS07555	COG4191	Histidine kinase
D3H41_RS07565	COG0488	(ABC) transporter
D3H41_RS07570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3H41_RS07600	COG3383	formate dehydrogenase (NAD+) activity
D3H41_RS07600	COG0243	molybdopterin cofactor binding
D3H41_RS07605	COG0437	4 iron, 4 sulfur cluster binding
D3H41_RS07720	COG0004	ammonium transporteR
D3H41_RS07725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3H41_RS07730	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3H41_RS07740	COG1177	transmembrane transport
D3H41_RS07750	COG3842	ATPase activity
D3H41_RS07775	COG0589	response to stress
D3H41_RS07780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H41_RS07795	COG2217	Heavy metal translocating P-type atpase
D3H41_RS07805	COG2010	Cytochrome c
D3H41_RS07820	COG3278	Belongs to the heme-copper respiratory oxidase family
D3H41_RS07835	COG2205	protein histidine kinase activity
D3H41_RS07835	COG0784	Response regulator, receiver
D3H41_RS08235	COG3120	sequence-specific DNA binding
D3H41_RS08240	COG1067	ATP-dependent peptidase activity
D3H41_RS08245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3H41_RS08260	COG0488	(ABC) transporter
D3H41_RS08270	COG0116	Belongs to the methyltransferase superfamily
D3H41_RS08270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D3H41_RS08280	COG0167	dihydroorotate dehydrogenase activity
D3H41_RS08290	COG2902	Dehydrogenase
D3H41_RS08300	COG0308	aminopeptidase N
D3H41_RS08315	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D3H41_RS08320	COG1956	GAF domain-containing protein
D3H41_RS08325	COG1132	(ABC) transporter
D3H41_RS08330	COG2995	paraquat-inducible protein a
D3H41_RS08335	COG3008	intermembrane lipid transfer
D3H41_RS08360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3H41_RS08365	COG1666	GTP binding
D3H41_RS08380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_RS08385	COG4597	amino acid ABC transporter
D3H41_RS08390	COG0765	amino acid transport
D3H41_RS08395	COG1126	abc transporter atp-binding protein
D3H41_RS08400	COG0670	Belongs to the BI1 family
D3H41_RS08410	COG2920	part of a sulfur-relay system
D3H41_RS08415	COG1254	Belongs to the acylphosphatase family
D3H41_RS08470	COG1414	Transcriptional regulator
D3H41_RS08480	COG0656	L-ascorbic acid biosynthetic process
D3H41_RS08485	COG0583	DNA-binding transcription factor activity
D3H41_RS08495	COG0583	DNA-binding transcription factor activity
D3H41_RS08500	COG2814	Major facilitator Superfamily
D3H41_RS08520	COG1335	isochorismatase
D3H41_RS08540	COG1410	methionine synthase
D3H41_RS08540	COG0646	methionine synthase
D3H41_RS08545	COG1126	abc transporter atp-binding protein
D3H41_RS08550	COG0765	amino acid transport
D3H41_RS08555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_RS08570	COG0583	DNA-binding transcription factor activity
D3H41_RS08585	COG0583	DNA-binding transcription factor activity
D3H41_RS08595	COG0583	DNA-binding transcription factor activity
D3H41_RS08610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3H41_RS08615	COG0602	queuosine metabolic process
D3H41_RS08620	COG0561	phosphatase activity
D3H41_RS08645	COG2828	Protein conserved in bacteria
D3H41_RS08655	COG0372	Belongs to the citrate synthase family
D3H41_RS08660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3H41_RS08695	COG0730	response to heat
D3H41_RS08700	COG2358	TRAP transporter, solute receptor (TAXI family
D3H41_RS08715	COG0457	Tetratricopeptide repeat
D3H41_RS08785	COG4790	Type iii secretion
D3H41_RS08790	COG4794	Type iii secretion
D3H41_RS08795	COG4791	protein targeting
D3H41_RS08800	COG4792	protein secretion
D3H41_RS08805	COG2207	Transcriptional regulator
D3H41_RS08835	COG3177	Filamentation induced by cAMP protein fic
D3H41_RS08855	COG4669	(LipO)protein
D3H41_RS08925	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_RS08930	COG3284	Transcriptional regulator
D3H41_RS08945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3H41_RS08950	COG0363	glucosamine-6-phosphate deaminase activity
D3H41_RS08955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D3H41_RS08960	COG2207	Transcriptional regulator
D3H41_RS08970	COG4565	transcriptional regulatory protein
D3H41_RS08975	COG3290	protein histidine kinase activity
D3H41_RS08990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_RS09005	COG0583	DNA-binding transcription factor activity
D3H41_RS09020	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3H41_RS09030	COG2985	domain, Protein
D3H41_RS09060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3H41_RS09065	COG0729	surface antigen
D3H41_RS09075	COG1280	lysine exporter protein (LysE YggA)
D3H41_RS09080	COG1280	lysine exporter protein (LysE YggA)
D3H41_RS09085	COG5507	3-demethylubiquinone-9 3-methyltransferase
D3H41_RS09105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3H41_RS09110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_RS09115	COG0110	maltose O-acetyltransferase activity
D3H41_RS09180	COG2801	Transposase and inactivated derivatives
D3H41_RS09190	COG2824	Alkylphosphonate utilization operon protein PhnA
D3H41_RS09640	COG2226	methyltransferase
D3H41_RS09790	COG1683	Conserved Protein
D3H41_RS09795	COG0456	acetyltransferase
D3H41_RS10095	COG1030	water channel activity
D3H41_RS10125	COG3772	lysozyme
D3H41_RS10160	COG1403	HNH endonuclease
D3H41_RS10180	COG1802	Transcriptional regulator
D3H41_RS10180	COG4626	Terminase
D3H41_RS10230	COG5532	Uncharacterized conserved protein (DUF2303)
D3H41_RS10250	COG0582	viral genome integration into host DNA
D3H41_RS10270	COG0653	protein targeting
D3H41_RS10285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_RS10295	COG3768	UPF0283 membrane protein
D3H41_RS10300	COG3106	COG3106 Predicted ATPase
D3H41_RS10320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3H41_RS10325	COG0784	Response regulator, receiver
D3H41_RS10325	COG2205	protein histidine kinase activity
D3H41_RS10335	COG0494	nUDIX hydrolase
D3H41_RS10340	COG0814	amino acid
D3H41_RS10345	COG1760	l-serine dehydratase
D3H41_RS10350	COG2200	EAL domain
D3H41_RS10360	COG0720	synthase
D3H41_RS10365	COG0840	transmembrane signaling receptor activity
D3H41_RS10370	COG0017	Asparaginyl-tRNA synthetase
D3H41_RS10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_RS10395	COG1448	Aminotransferase
D3H41_RS10415	COG0840	transmembrane signaling receptor activity
D3H41_RS10420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_RS10450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3H41_RS10465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H41_RS10470	COG3108	Peptidase M15
D3H41_RS10475	COG2989	Protein conserved in bacteria
D3H41_RS10500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3H41_RS10510	COG4235	cytochrome complex assembly
D3H41_RS10510	COG3088	subunit of a heme lyase
D3H41_RS10520	COG1138	Cytochrome C-type biogenesis protein
D3H41_RS10525	COG3301	Polysulphide reductase, NrfD
D3H41_RS10530	COG0437	4 iron, 4 sulfur cluster binding
D3H41_RS10540	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D3H41_RS10560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H41_RS10565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3H41_RS10595	COG0019	diaminopimelate decarboxylase activity
D3H41_RS10635	COG0322	excinuclease ABC activity
D3H41_RS10640	COG2197	response regulator
D3H41_RS10645	COG0417	DNA replication proofreading
D3H41_RS10665	COG1187	pseudouridine synthase activity
D3H41_RS10675	COG0009	L-threonylcarbamoyladenylate synthase
D3H41_RS10680	COG0613	PHP domain protein
D3H41_RS10690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3H41_RS10695	COG0512	Glutamine amidotransferase of anthranilate synthase
D3H41_RS10705	COG0134	indole-3-glycerol-phosphate synthase activity
D3H41_RS10705	COG0135	phosphoribosylanthranilate isomerase activity
D3H41_RS10715	COG0159	tryptophan synthase activity
D3H41_RS10720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H41_RS10725	COG0318	PFAM AMP-dependent synthetase and ligase
D3H41_RS10735	COG1301	dicarboxylic acid transport
D3H41_RS10755	COG2917	probably involved in intracellular septation
D3H41_RS10765	COG2350	Protein conserved in bacteria
D3H41_RS10775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D3H41_RS10780	COG0583	DNA-binding transcription factor activity
D3H41_RS10795	COG5001	Diguanylate cyclase
D3H41_RS10800	COG1032	radical SAM domain protein
D3H41_RS10820	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D3H41_RS10825	COG0463	Glycosyl transferase, family 2
D3H41_RS10830	COG0745	RESPONSE REGULATOR receiver
D3H41_RS10835	COG3850	Histidine kinase
D3H41_RS10835	COG5002	protein histidine kinase activity
D3H41_RS10890	COG0577	efflux transmembrane transporter activity
D3H41_RS10890	COG1136	(ABC) transporter
D3H41_RS10895	COG0577	efflux transmembrane transporter activity
D3H41_RS10895	COG1136	(ABC) transporter
D3H41_RS10900	COG0577	efflux transmembrane transporter activity
D3H41_RS10900	COG1136	(ABC) transporter
D3H41_RS10910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_RS10930	COG3118	belongs to the thioredoxin family
D3H41_RS10990	COG4232	protein-disulfide reductase activity
D3H41_RS10995	COG3118	belongs to the thioredoxin family
D3H41_RS11040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_RS11060	COG3118	belongs to the thioredoxin family
D3H41_RS11065	COG4232	protein-disulfide reductase activity
D3H41_RS11100	COG2863	cytochrome
D3H41_RS11105	COG3258	Cytochrome c
D3H41_RS11110	COG2995	paraquat-inducible protein a
D3H41_RS11115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3H41_RS11115	COG3008	intermembrane lipid transfer
D3H41_RS11135	COG4166	transmembrane transport
D3H41_RS11145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D3H41_RS11150	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D3H41_RS11160	COG0539	negative regulation of cytoplasmic translation
D3H41_RS11165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D3H41_RS11170	COG0616	signal peptide processing
D3H41_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS11190	COG0587	DNA-directed DNA polymerase activity
D3H41_RS11195	COG0835	chemotaxis
D3H41_RS11195	COG0784	Response regulator, receiver
D3H41_RS11200	COG1940	carbohydrate kinase activity
D3H41_RS11205	COG0469	pyruvate kinase activity
D3H41_RS11210	COG4667	esterase of the alpha-beta hydrolase superfamily
D3H41_RS11225	COG0733	neurotransmitter:sodium symporter activity
D3H41_RS11240	COG1263	PTS System
D3H41_RS11240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_RS11245	COG0084	hydrolase, TatD family'
D3H41_RS11250	COG0470	DNA polymerase III
D3H41_RS11255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3H41_RS11260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3H41_RS11290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H41_RS11295	COG0416	fatty acid biosynthetic process
D3H41_RS11305	COG1399	metal-binding, possibly nucleic acid-binding protein
D3H41_RS11310	COG0424	maF-like protein
D3H41_RS11315	COG0564	pseudouridine synthase activity
D3H41_RS11325	COG1530	ribonuclease E activity
D3H41_RS11335	COG0659	secondary active sulfate transmembrane transporter activity
D3H41_RS11340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3H41_RS11345	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D3H41_RS11355	COG0572	uridine kinase
D3H41_RS11365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H41_RS11365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H41_RS11385	COG2186	Transcriptional regulator
D3H41_RS11390	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H41_RS11395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D3H41_RS11400	COG3012	SEC-C Motif Domain Protein
D3H41_RS11400	COG3318	Belongs to the UPF0149 family
D3H41_RS11405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3H41_RS11410	COG3706	GGDEF domain
D3H41_RS11415	COG0366	Alpha amylase catalytic
D3H41_RS11420	COG1122	ATPase activity
D3H41_RS11425	COG4120	Belongs to the binding-protein-dependent transport system permease family
D3H41_RS11435	COG3092	negative regulation of chromosome organization
D3H41_RS11440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3H41_RS11445	COG0280	phosphate acetyltransferase
D3H41_RS11445	COG0857	belongs to the CobB CobQ family
D3H41_RS11455	COG0435	Glutathione S-transferase
D3H41_RS11465	COG0444	Belongs to the ABC transporter superfamily
D3H41_RS11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H41_RS11475	COG0601	transmembrane transport
D3H41_RS11485	COG0314	molybdopterin synthase activity
D3H41_RS11490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3H41_RS11495	COG0315	cyclic pyranopterin monophosphate synthase activity
D3H41_RS11500	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3H41_RS11505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3H41_RS11510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D3H41_RS11515	COG2198	Histidine kinase
D3H41_RS11520	COG2204	response regulator
D3H41_RS11525	COG0556	nucleotide-excision repair
D3H41_RS11535	COG1882	Formate acetyltransferase
D3H41_RS11540	COG4657	Part of a membrane complex involved in electron transport
D3H41_RS11545	COG2878	Part of a membrane complex involved in electron transport
D3H41_RS11550	COG4656	Part of a membrane complex involved in electron transport
D3H41_RS11555	COG4658	electron transport chain
D3H41_RS11560	COG4659	FMN binding
D3H41_RS11565	COG4660	Part of a membrane complex involved in electron transport
D3H41_RS11570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3H41_RS11575	COG0346	lactoylglutathione lyase activity
D3H41_RS11585	COG2885	chlorophyll binding
D3H41_RS11595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3H41_RS11600	COG2056	Na+-H+ antiporter family
D3H41_RS11620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3H41_RS11640	COG1454	alcohol dehydrogenase
D3H41_RS11640	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_RS11645	COG2095	MarC family integral membrane protein
D3H41_RS11650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H41_RS11655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3H41_RS11660	COG1757	Na H antiporter
D3H41_RS11675	COG3081	Nucleoid-associated protein
D3H41_RS11680	COG3082	Protein of unknown function (DUF1414)
D3H41_RS11695	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3H41_RS11710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3H41_RS11715	COG0778	Nitroreductase
D3H41_RS11725	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3H41_RS11725	COG1902	pentaerythritol trinitrate reductase activity
D3H41_RS11730	COG0616	signal peptide processing
D3H41_RS11735	COG0252	asparaginase activity
D3H41_RS11740	COG3139	Protein of unknown function (DUF1315)
D3H41_RS11750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_RS11755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3H41_RS11770	COG2226	methyltransferase
D3H41_RS11790	COG1785	Belongs to the alkaline phosphatase family
D3H41_RS11800	COG0346	lactoylglutathione lyase activity
D3H41_RS11805	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D3H41_RS11810	COG0668	transmembrane transport
D3H41_RS11815	COG2983	Belongs to the UPF0260 family
D3H41_RS11820	COG2261	transglycosylase associated protein
D3H41_RS11830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3H41_RS11835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D3H41_RS11850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3H41_RS11855	COG2832	Protein of unknown function (DUF454)
D3H41_RS11865	COG0745	RESPONSE REGULATOR receiver
D3H41_RS11870	COG0583	DNA-binding transcription factor activity
D3H41_RS11875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3H41_RS11880	COG1286	toxin biosynthetic process
D3H41_RS11885	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D3H41_RS11890	COG0285	dihydrofolate synthase activity
D3H41_RS11895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3H41_RS11905	COG0101	tRNA pseudouridine synthase activity
D3H41_RS11915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3H41_RS11920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H41_RS11930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3H41_RS11935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H41_RS11935	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D3H41_RS11940	COG0431	NADPH-dependent FMN reductase
D3H41_RS11955	COG3101	peptidyl-lysine hydroxylation
D3H41_RS11965	COG2860	membrane
D3H41_RS11970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3H41_RS11975	COG2890	protein-(glutamine-N5) methyltransferase activity
D3H41_RS11980	COG2840	Smr protein MutS2
D3H41_RS11985	COG2062	phosphohistidine phosphatase, SixA
D3H41_RS12000	COG1024	Enoyl-CoA hydratase
D3H41_RS12000	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3H41_RS12005	COG0183	Belongs to the thiolase family
D3H41_RS12030	COG2067	long-chain fatty acid transport protein
D3H41_RS12040	COG3088	subunit of a heme lyase
D3H41_RS12040	COG4235	cytochrome complex assembly
D3H41_RS12050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H41_RS12055	COG1138	Cytochrome C-type biogenesis protein
D3H41_RS12060	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D3H41_RS12065	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3H41_RS12070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3H41_RS12075	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3H41_RS12080	COG4133	protoheme IX ABC transporter activity
D3H41_RS12090	COG0835	chemotaxis
D3H41_RS12100	COG1192	Involved in chromosome partitioning
D3H41_RS12105	COG2201	protein-glutamate methylesterase activity
D3H41_RS12110	COG0784	Response regulator, receiver
D3H41_RS12110	COG0643	Histidine kinase
D3H41_RS12110	COG2198	Histidine kinase
D3H41_RS12115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D3H41_RS12150	COG1684	flagellar biosynthetic protein fliR
D3H41_RS12155	COG1987	bacterial-type flagellum assembly
D3H41_RS12210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3H41_RS12220	COG1677	Flagellar hook-basal body complex protein FliE
D3H41_RS12240	COG1516	flagellar protein fliS
D3H41_RS12250	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D3H41_RS12255	COG1334	flagellar protein FlaG
D3H41_RS12260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_RS12265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_RS12275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_RS12280	COG2837	iron assimilation
D3H41_RS12305	COG1393	Belongs to the ArsC family
D3H41_RS12310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3H41_RS12325	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D3H41_RS12330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H41_RS12340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3H41_RS12355	COG4783	chaperone-mediated protein folding
D3H41_RS12360	COG1393	Belongs to the ArsC family
D3H41_RS12380	COG2233	PERMEase
D3H41_RS12385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3H41_RS12390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3H41_RS12395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3H41_RS12400	COG0121	glutamine amidotransferase
D3H41_RS12405	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3H41_RS12410	COG1960	acyl-CoA dehydrogenase activity
D3H41_RS12445	COG0328	RNA-DNA hybrid ribonuclease activity
D3H41_RS12450	COG2226	methyltransferase
D3H41_RS12455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H41_RS12460	COG1388	LysM domain
D3H41_RS12460	COG0741	lytic transglycosylase activity
D3H41_RS12470	COG3021	interspecies interaction between organisms
D3H41_RS12475	COG0347	Belongs to the P(II) protein family
D3H41_RS12490	COG0825	malonyl-CoA metabolic process
D3H41_RS12495	COG0587	DNA-directed DNA polymerase activity
D3H41_RS12505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H41_RS12510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H41_RS12520	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H41_RS12525	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D3H41_RS12535	COG0750	zinc metalloprotease
D3H41_RS12540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3H41_RS12545	COG0575	Belongs to the CDS family
D3H41_RS12550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3H41_RS12555	COG0233	cytoplasmic translational termination
D3H41_RS12560	COG0528	UMP kinase activity
D3H41_RS12565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3H41_RS12570	COG0052	Belongs to the universal ribosomal protein uS2 family
D3H41_RS12575	COG0024	Methionine aminopeptidase
D3H41_RS12580	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D3H41_RS12590	COG0564	pseudouridine synthase activity
D3H41_RS12595	COG3098	single-species biofilm formation
D3H41_RS12630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H41_RS12635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3H41_RS12660	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D3H41_RS12670	COG0254	rRNA binding
D3H41_RS12675	COG1720	tRNA m6t6A37 methyltransferase activity
D3H41_RS12680	COG0442	prolyl-tRNA aminoacylation
D3H41_RS12700	COG0733	neurotransmitter:sodium symporter activity
D3H41_RS12715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H41_RS12720	COG0514	ATP-dependent DNA helicase (RecQ)
D3H41_RS12725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3H41_RS12745	COG1477	protein flavinylation
D3H41_RS12750	COG2871	sodium ion transport
D3H41_RS12755	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D3H41_RS12760	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D3H41_RS12765	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D3H41_RS12770	COG1805	sodium ion transport
D3H41_RS12775	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D3H41_RS12780	COG0271	Belongs to the BolA IbaG family
D3H41_RS12785	COG2813	Specifically methylates the guanine in position
D3H41_RS12790	COG3056	Lipoprotein
D3H41_RS12810	COG1595	DNA-templated transcription, initiation
D3H41_RS12830	COG3248	Nucleoside-binding outer membrane protein
D3H41_RS12835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3H41_RS12840	COG0693	protein deglycase activity
D3H41_RS12845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3H41_RS12850	COG3706	GGDEF domain
D3H41_RS12855	COG2166	iron-sulfur cluster assembly
D3H41_RS12860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D3H41_RS12865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3H41_RS12880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3H41_RS12880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3H41_RS12900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3H41_RS12905	COG1074	ATP-dependent DNA helicase activity
D3H41_RS12910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D3H41_RS12930	COG3141	response to X-ray
D3H41_RS12945	COG2171	N-acyltransferase activity
D3H41_RS12950	COG0584	glycerophosphoryl diester phosphodiesterase
D3H41_RS12955	COG2271	Major facilitator Superfamily
D3H41_RS12965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3H41_RS12970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3H41_RS12975	COG1349	DNA-binding transcription factor activity
D3H41_RS12980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3H41_RS12985	COG0598	Magnesium transport protein CorA
D3H41_RS13005	COG1609	Transcriptional regulator
D3H41_RS13010	COG0583	DNA-binding transcription factor activity
D3H41_RS13070	COG4964	Belongs to the GSP D family
D3H41_RS13095	COG2169	Transcriptional regulator
D3H41_RS13100	COG1022	Amp-dependent synthetase and ligase
D3H41_RS13110	COG0583	DNA-binding transcription factor activity
D3H41_RS13115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3H41_RS13120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D3H41_RS13130	COG0560	Phosphoserine phosphatase
D3H41_RS13140	COG0813	purine-nucleoside phosphorylase activity
D3H41_RS13145	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D3H41_RS13150	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D3H41_RS13155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3H41_RS13160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3H41_RS13165	COG0084	hydrolase, TatD family'
D3H41_RS13195	COG3153	acetyltransferase
D3H41_RS13200	COG3154	lipid carrier protein
D3H41_RS13215	COG0826	peptidase U32
D3H41_RS13220	COG0826	peptidase U32
D3H41_RS13225	COG0534	Mate efflux family protein
D3H41_RS13240	COG1185	polyribonucleotide nucleotidyltransferase activity
D3H41_RS13245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D3H41_RS13250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3H41_RS13255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D3H41_RS13260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D3H41_RS13265	COG0195	Participates in both transcription termination and antitermination
D3H41_RS13270	COG0779	Required for maturation of 30S ribosomal subunits
D3H41_RS13285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3H41_RS13295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H41_RS13300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3H41_RS13305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3H41_RS13310	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D3H41_RS13315	COG1534	Rna-binding protein
D3H41_RS13320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H41_RS13325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3H41_RS13330	COG2027	D-alanyl-D-alanine carboxypeptidase
D3H41_RS13340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3H41_RS13345	COG0739	heme binding
D3H41_RS13370	COG0628	permease
D3H41_RS13380	COG2205	protein histidine kinase activity
D3H41_RS13380	COG0784	Response regulator, receiver
D3H41_RS13385	COG0747	negative chemotaxis
D3H41_RS13395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H41_RS13400	COG0444	Belongs to the ABC transporter superfamily
D3H41_RS13405	COG4608	Belongs to the ABC transporter superfamily
D3H41_RS13415	COG2971	BadF BadG BcrA BcrD
D3H41_RS13430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H41_RS13435	COG3842	ATPase activity
D3H41_RS13445	COG1840	ABC-type Fe3 transport system, periplasmic component
D3H41_RS13450	COG0004	ammonium transporteR
D3H41_RS13460	COG3112	Uncharacterised protein family (UPF0231)
D3H41_RS13465	COG1049	propionate catabolic process, 2-methylcitrate cycle
D3H41_RS13470	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3H41_RS13475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3H41_RS13480	COG1643	Atp-dependent helicase
D3H41_RS13485	COG1489	DNA binding
D3H41_RS13495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3H41_RS13505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3H41_RS13510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3H41_RS13515	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D3H41_RS13520	COG1560	Kdo2-lipid A biosynthetic process
D3H41_RS13530	COG0842	Transport permease protein
D3H41_RS13535	COG1131	(ABC) transporter
D3H41_RS13540	COG0659	secondary active sulfate transmembrane transporter activity
D3H41_RS13545	COG0288	reversible hydration of carbon dioxide
D3H41_RS13560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H41_RS13565	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3H41_RS13570	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D3H41_RS13575	COG2186	Transcriptional regulator
D3H41_RS13585	COG0157	Belongs to the NadC ModD family
D3H41_RS13595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3H41_RS13600	COG1459	type II secretion system
D3H41_RS13610	COG0237	dephospho-CoA kinase activity
D3H41_RS13615	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D3H41_RS13620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D3H41_RS13635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3H41_RS13640	COG0228	four-way junction DNA binding
D3H41_RS13645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3H41_RS13650	COG4137	Cytochrome C assembly protein
D3H41_RS13655	COG4536	flavin adenine dinucleotide binding
D3H41_RS13660	COG1854	S-ribosylhomocysteine lyase activity
D3H41_RS13675	COG0612	Peptidase, M16
D3H41_RS13680	COG1238	metal cluster binding
D3H41_RS13690	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D3H41_RS13695	COG5016	pyruvate
D3H41_RS13695	COG0511	ligase activity, forming carbon-carbon bonds
D3H41_RS13700	COG3630	sodium ion export across plasma membrane
D3H41_RS13760	COG0527	aspartate kinase activity
D3H41_RS13765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3H41_RS13770	COG2137	regulation of response to DNA damage stimulus
D3H41_RS13780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D3H41_RS13785	COG1546	Belongs to the CinA family
D3H41_RS13790	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3H41_RS13795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3H41_RS13805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3H41_RS13810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D3H41_RS13820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D3H41_RS13825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D3H41_RS13830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D3H41_RS13835	COG0148	phosphopyruvate hydratase activity
D3H41_RS13840	COG0504	CTP synthase activity
D3H41_RS13845	COG3956	TIGRFAM MazG family protein
D3H41_RS13850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3H41_RS13860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3H41_RS13875	COG0736	holo-[acyl-carrier-protein] synthase activity
D3H41_RS13880	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3H41_RS13885	COG1381	Involved in DNA repair and RecF pathway recombination
D3H41_RS13890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3H41_RS13900	COG0681	Belongs to the peptidase S26 family
D3H41_RS13905	COG0481	GTPase activity
D3H41_RS13910	COG3086	response to oxidative stress
D3H41_RS13925	COG1595	DNA-templated transcription, initiation
D3H41_RS13935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3H41_RS13945	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D3H41_RS13965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3H41_RS13970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3H41_RS13975	COG3079	Belongs to the UPF0149 family
D3H41_RS13985	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D3H41_RS13995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3H41_RS14000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D3H41_RS14005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H41_RS14015	COG0583	DNA-binding transcription factor activity
D3H41_RS14030	COG0668	transmembrane transport
D3H41_RS14035	COG0191	fructose-bisphosphate aldolase activity
D3H41_RS14050	COG4771	TonB-dependent receptor
D3H41_RS14055	COG0583	DNA-binding transcription factor activity
D3H41_RS14060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3H41_RS14070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3H41_RS14085	COG2356	endonuclease I
D3H41_RS14090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3H41_RS14095	COG0189	ligase activity
D3H41_RS14100	COG1678	Uncharacterized ACR, COG1678
D3H41_RS14105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3H41_RS14120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D3H41_RS14125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3H41_RS14130	COG0762	integral membrane protein
D3H41_RS14135	COG1872	DUF167
D3H41_RS14145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3H41_RS14150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3H41_RS14155	COG2066	Belongs to the glutaminase family
D3H41_RS14165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3H41_RS14175	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D3H41_RS14220	COG0840	transmembrane signaling receptor activity
D3H41_RS14295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D3H41_RS14300	COG1609	Transcriptional regulator
D3H41_RS14305	COG3394	polysaccharide catabolic process
D3H41_RS14310	COG1486	melibiose metabolic process
D3H41_RS14315	COG1447	Phosphotransferase system cellobiose-specific component IIA
D3H41_RS14320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D3H41_RS14325	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D3H41_RS14330	COG0726	polysaccharide deacetylase
D3H41_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS14355	COG0795	lipopolysaccharide-transporting ATPase activity
D3H41_RS14360	COG0795	lipopolysaccharide-transporting ATPase activity
D3H41_RS14365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3H41_RS14370	COG2927	DNA polymerase III (CHI subunit)
D3H41_RS14375	COG0525	valine-tRNA ligase activity
D3H41_RS14385	COG0456	acetyltransferase
D3H41_RS14415	COG0540	Belongs to the ATCase OTCase family
D3H41_RS14420	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D3H41_RS14425	COG0251	oxidation-reduction process
D3H41_RS14430	COG0204	Acyl-transferase
D3H41_RS14435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3H41_RS14440	COG5007	Belongs to the BolA IbaG family
D3H41_RS14450	COG2854	intermembrane phospholipid transfer
D3H41_RS14455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3H41_RS14460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3H41_RS14465	COG1127	ABC transporter
D3H41_RS14475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D3H41_RS14475	COG0517	IMP dehydrogenase activity
D3H41_RS14485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D3H41_RS14490	COG1137	ATPase activity
D3H41_RS14500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3H41_RS14505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_RS14510	COG1660	Displays ATPase and GTPase activities
D3H41_RS14515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_RS14520	COG2239	Acts as a magnesium transporter
D3H41_RS14525	COG0312	modulator of DNA gyrase
D3H41_RS14530	COG3028	Belongs to the UPF0307 family
D3H41_RS14535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3H41_RS14540	COG0564	pseudouridine synthase activity
D3H41_RS14550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3H41_RS14555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D3H41_RS14560	COG0312	modulator of DNA gyrase
D3H41_RS14565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3H41_RS14570	COG3164	Protein of unknown function
D3H41_RS14580	COG0424	maF-like protein
D3H41_RS14585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D3H41_RS14590	COG1792	Involved in formation and maintenance of cell shape
D3H41_RS14595	COG1077	Cell shape determining protein MreB Mrl
D3H41_RS14630	COG2165	general secretion pathway protein
D3H41_RS14640	COG1459	type II secretion system
D3H41_RS14645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3H41_RS14655	COG3267	Type II secretory pathway component ExeA
D3H41_RS14655	COG3409	Peptidoglycan-binding domain 1 protein
D3H41_RS14660	COG1450	Type ii and iii secretion system protein
D3H41_RS14680	COG2199	diguanylate cyclase activity
D3H41_RS14680	COG2200	EAL domain
D3H41_RS14685	COG0629	single-stranded DNA binding
D3H41_RS14700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3H41_RS14710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D3H41_RS14720	COG0527	aspartate kinase activity
D3H41_RS14725	COG0646	methionine synthase
D3H41_RS14725	COG1410	methionine synthase
D3H41_RS14790	COG0175	sulfate reduction
D3H41_RS14795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H41_RS14800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3H41_RS14820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3H41_RS14825	COG0735	belongs to the Fur family
D3H41_RS14835	COG0166	Belongs to the GPI family
D3H41_RS14840	COG0432	Pfam Uncharacterised protein family UPF0047
D3H41_RS14845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3H41_RS14870	COG2965	DNA replication, synthesis of RNA primer
D3H41_RS14875	COG0360	Binds together with S18 to 16S ribosomal RNA
D3H41_RS14880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3H41_RS14885	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D3H41_RS14895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3H41_RS14900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D3H41_RS14930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3H41_RS14940	COG0678	peroxiredoxin activity
D3H41_RS14940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3H41_RS14945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H41_RS14955	COG0165	Argininosuccinate lyase
D3H41_RS14955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3H41_RS14960	COG0137	argininosuccinate synthase activity
D3H41_RS14970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3H41_RS14980	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3H41_RS14990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D3H41_RS14995	COG0527	aspartate kinase activity
D3H41_RS14995	COG0460	homoserine dehydrogenase
D3H41_RS15000	COG0626	cystathionine gamma-synthase activity
D3H41_RS15005	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D3H41_RS15010	COG0281	malic enzyme
D3H41_RS15025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3H41_RS15030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3H41_RS15050	COG2923	Belongs to the DsrF TusC family
D3H41_RS15055	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D3H41_RS15060	COG2964	Protein conserved in bacteria
D3H41_RS15065	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H41_RS15080	COG1446	asparaginase
D3H41_RS15090	COG1047	Peptidyl-prolyl cis-trans
D3H41_RS15105	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3H41_RS15110	COG0488	(ABC) transporter
D3H41_RS15120	COG0429	hydrolase of the alpha beta-hydrolase fold
D3H41_RS15130	COG3954	Phosphoribulokinase
D3H41_RS15135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H41_RS15155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3H41_RS15160	COG0512	Glutamine amidotransferase of anthranilate synthase
D3H41_RS15175	COG0180	Tryptophanyl-tRNA synthetase
D3H41_RS15180	COG0546	phosphoglycolate phosphatase activity
D3H41_RS15185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H41_RS15190	COG0557	exoribonuclease II activity
D3H41_RS15195	COG1959	2 iron, 2 sulfur cluster binding
D3H41_RS15200	COG1017	nitric oxide dioxygenase activity
D3H41_RS15200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3H41_RS15205	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D3H41_RS15215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3H41_RS15220	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D3H41_RS15225	COG0330	HflC and HflK could
D3H41_RS15230	COG0330	HflC and HflK could
D3H41_RS15235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3H41_RS15245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3H41_RS15250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3H41_RS15260	COG0802	atpase or kinase
D3H41_RS15270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3H41_RS15335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D3H41_RS15340	COG1162	GTPase activity
D3H41_RS15345	COG0688	phosphatidylethanolamine metabolic process
D3H41_RS15350	COG3273	potassium ion transport
D3H41_RS15350	COG0471	metal ion transport
D3H41_RS15360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3H41_RS15365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H41_RS15370	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D3H41_RS15375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3H41_RS15380	COG1045	serine acetyltransferase
D3H41_RS15385	COG4942	peptidase
D3H41_RS15405	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D3H41_RS15410	COG1053	succinate dehydrogenase
D3H41_RS15415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3H41_RS15420	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D3H41_RS15425	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D3H41_RS15440	COG1509	lysine 2,3-aminomutase activity
D3H41_RS15445	COG1285	pathogenesis
D3H41_RS15455	COG0459	protein refolding
D3H41_RS15465	COG0534	Mate efflux family protein
D3H41_RS15470	COG0205	6-phosphofructokinase activity
D3H41_RS15480	COG3678	ATP-independent chaperone mediated protein folding
D3H41_RS15485	COG0745	RESPONSE REGULATOR receiver
D3H41_RS15490	COG2205	protein histidine kinase activity
D3H41_RS15500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3H41_RS15510	COG1027	Aspartate ammonia-lyase
D3H41_RS15515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3H41_RS15520	COG4232	protein-disulfide reductase activity
D3H41_RS15530	COG3263	regulation of cellular component size
D3H41_RS15540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H41_RS15560	COG2205	protein histidine kinase activity
D3H41_RS15560	COG2198	Histidine kinase
D3H41_RS15560	COG0784	Response regulator, receiver
D3H41_RS15565	COG2814	Major facilitator Superfamily
D3H41_RS15580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3H41_RS15585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3H41_RS15590	COG0511	ligase activity, forming carbon-carbon bonds
D3H41_RS15595	COG0439	Biotin carboxylase
D3H41_RS15605	COG2264	protein methyltransferase activity
D3H41_RS15610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3H41_RS15615	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D3H41_RS15625	COG0488	(ABC) transporter
D3H41_RS15690	COG1982	Orn Lys Arg decarboxylase major
D3H41_RS15695	COG0531	amino acid
D3H41_RS15705	COG3710	Transcriptional regulator
D3H41_RS15720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3H41_RS15725	COG0222	ribosome binding
D3H41_RS15745	COG2816	NAD+ diphosphatase activity
D3H41_RS15750	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D3H41_RS15760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3H41_RS15765	COG0085	RNA polymerase activity
D3H41_RS15770	COG0222	ribosome binding
D3H41_RS15775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3H41_RS15790	COG0250	Participates in transcription elongation, termination and antitermination
D3H41_RS15795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3H41_RS15805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3H41_RS15840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D3H41_RS15840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D3H41_RS15845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3H41_RS15855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3H41_RS15920	COG4206	TonB-dependent receptor
D3H41_RS15940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H41_RS15945	COG0534	Mate efflux family protein
D3H41_RS15950	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D3H41_RS15960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3H41_RS15970	COG2937	Belongs to the GPAT DAPAT family
D3H41_RS15975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3H41_RS15980	COG3161	chorismate lyase activity
D3H41_RS15985	COG1580	Controls the rotational direction of flagella during chemotaxis
D3H41_RS15990	COG0705	Rhomboid family
D3H41_RS15995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H41_RS16010	COG2177	Part of the ABC transporter FtsEX involved in
D3H41_RS16015	COG2884	Cell division ATP-binding protein ftsE
D3H41_RS16020	COG0552	protein localization to endoplasmic reticulum
D3H41_RS16025	COG0742	ribosomal rna small subunit methyltransferase
D3H41_RS16035	COG2095	MarC family integral membrane protein
D3H41_RS16080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3H41_RS16085	COG0640	Transcriptional regulator
D3H41_RS16090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D3H41_RS16095	COG1280	lysine exporter protein (LysE YggA)
D3H41_RS16100	COG2267	carboxylic ester hydrolase activity
D3H41_RS16105	COG0561	phosphatase activity
D3H41_RS16120	COG3148	PFAM DTW domain containing protein
D3H41_RS16125	COG2200	EAL domain
D3H41_RS16125	COG3287	FIST C domain
D3H41_RS16125	COG2199	diguanylate cyclase activity
D3H41_RS16130	COG1011	Hydrolase
D3H41_RS16135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D3H41_RS16150	COG0019	diaminopimelate decarboxylase activity
D3H41_RS16160	COG1965	Belongs to the frataxin family
D3H41_RS16165	COG3072	Adenylate cyclase
D3H41_RS16170	COG0181	hydroxymethylbilane synthase activity
D3H41_RS16175	COG1587	Uroporphyrinogen-III synthase
D3H41_RS16180	COG2959	enzyme of heme biosynthesis
D3H41_RS16185	COG3071	HemY protein
D3H41_RS16230	COG0633	Ferredoxin
D3H41_RS16235	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3H41_RS16250	COG3118	belongs to the thioredoxin family
D3H41_RS16255	COG0513	Belongs to the DEAD box helicase family
D3H41_RS16260	COG0248	Ppx GppA phosphatase
D3H41_RS16270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D3H41_RS16285	COG0514	ATP-dependent DNA helicase (RecQ)
D3H41_RS16290	COG2962	Rard protein
D3H41_RS16300	COG1280	lysine exporter protein (LysE YggA)
D3H41_RS16305	COG0405	Gamma-glutamyltransferase
D3H41_RS16315	COG0210	DNA helicase
D3H41_RS16325	COG3220	belongs to the UPF0276 family
D3H41_RS16355	COG0006	proline dipeptidase activity
D3H41_RS16355	COG0006	proline dipeptidase activity
D3H41_RS16370	COG2104	thiamine diphosphate biosynthetic process
D3H41_RS16375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3H41_RS16395	COG2132	Multicopper oxidase
D3H41_RS16440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3H41_RS16455	COG0408	coproporphyrinogen oxidase activity
D3H41_RS16460	COG0009	L-threonylcarbamoyladenylate synthase
D3H41_RS16465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3H41_RS16470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3H41_RS16480	COG0551	DNA topoisomerase type I activity
D3H41_RS16490	COG2922	Belongs to the Smg family
D3H41_RS16495	COG0758	DNA mediated transformation
D3H41_RS16505	COG0242	peptide deformylase activity
D3H41_RS16510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3H41_RS16515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3H41_RS16515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3H41_RS16520	COG0569	domain protein
D3H41_RS16525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3H41_RS16535	COG1272	protein, Hemolysin III
D3H41_RS16540	COG4326	sporulation control protein
D3H41_RS16550	COG3084	Protein conserved in bacteria
D3H41_RS16560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D3H41_RS16565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3H41_RS16570	COG0204	Acyl-transferase
D3H41_RS16580	COG0606	chelatase, subunit chli
D3H41_RS16590	COG3978	acetolactate synthase activity
D3H41_RS16595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3H41_RS16600	COG0129	dihydroxy-acid dehydratase activity
D3H41_RS16610	COG0583	DNA-binding transcription factor activity
D3H41_RS16615	COG2814	Major facilitator Superfamily
D3H41_RS16625	COG0765	amino acid transport
D3H41_RS16635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D3H41_RS16640	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D3H41_RS16645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3H41_RS16650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3H41_RS16655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3H41_RS16660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3H41_RS16670	COG0356	it plays a direct role in the translocation of protons across the membrane
D3H41_RS16675	COG3312	ion transport
D3H41_RS16680	COG1475	DNA binding
D3H41_RS16685	COG1192	Involved in chromosome partitioning
D3H41_RS16690	COG0357	Ribosomal RNA small subunit methyltransferase G
D3H41_RS16695	COG0445	tRNA wobble uridine modification
D3H41_RS16700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3H41_RS16715	COG1395	domain, Protein
D3H41_RS16750	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D3H41_RS16785	COG4974	Belongs to the 'phage' integrase family
D3H41_RS16795	COG0706	membrane insertase activity
D3H41_RS16805	COG0594	ribonuclease P activity
D3H41_RS16815	COG1126	abc transporter atp-binding protein
D3H41_RS16840	COG0730	response to heat
D3H41_RS16850	COG0513	Belongs to the DEAD box helicase family
D3H41_RS16855	COG4628	conserved protein (DUF2132)
D3H41_RS16865	COG0133	tryptophan synthase activity
D3H41_RS16875	COG1278	Cold shock
D3H41_RS16885	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D3H41_RS16895	COG0523	cobalamin synthesis protein
D3H41_RS16900	COG0513	Belongs to the DEAD box helicase family
D3H41_RS16920	COG2200	EAL domain
D3H41_RS16925	COG1119	ATPase activity
D3H41_RS16965	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D3H41_RS16970	COG0513	Belongs to the DEAD box helicase family
D3H41_RS16990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3H41_RS17000	COG1073	alpha beta
D3H41_RS17005	COG1073	alpha beta
D3H41_RS17020	COG0436	Aminotransferase
D3H41_RS17090	COG0277	FAD linked oxidase domain protein
D3H41_RS17090	COG0247	lactate metabolic process
D3H41_RS17105	COG1024	Enoyl-CoA hydratase
D3H41_RS17110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3H41_RS17115	COG1960	acyl-CoA dehydrogenase activity
D3H41_RS17125	COG0183	Belongs to the thiolase family
D3H41_RS17140	COG1024	Enoyl-CoA hydratase
D3H41_RS17145	COG1024	Enoyl-CoA hydratase
D3H41_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS17160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3H41_RS17165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3H41_RS17170	COG1845	cytochrome c oxidase, subunit III
D3H41_RS17175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D3H41_RS17180	COG0109	protoheme IX farnesyltransferase activity
D3H41_RS17185	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3H41_RS17185	COG1902	pentaerythritol trinitrate reductase activity
D3H41_RS17200	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_RS17210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_RS17240	COG1126	abc transporter atp-binding protein
D3H41_RS17245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_RS17250	COG4215	(ABC) transporter
D3H41_RS17255	COG4160	amino acid transport
D3H41_RS17325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H41_RS17330	COG2176	DNA-directed DNA polymerase activity
D3H41_RS17335	COG0517	IMP dehydrogenase activity
D3H41_RS17340	COG2186	Transcriptional regulator
D3H41_RS17345	COG2186	Transcriptional regulator
D3H41_RS17390	COG1917	Cupin 2, conserved barrel domain protein
D3H41_RS17395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_RS17400	COG0800	Aldolase
D3H41_RS17410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3H41_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS17420	COG2847	Copper chaperone PCu(A)C
D3H41_RS17495	COG0814	amino acid
D3H41_RS17505	COG0243	molybdopterin cofactor binding
D3H41_RS17525	COG3707	response regulator
D3H41_RS17535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3H41_RS17535	COG1116	anion transmembrane transporter activity
D3H41_RS17540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3H41_RS17545	COG1116	anion transmembrane transporter activity
D3H41_RS17550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H41_RS17550	COG2146	nitrite reductase [NAD(P)H] activity
D3H41_RS17600	COG2815	serine threonine protein kinase
D3H41_RS17600	COG0515	serine threonine protein kinase
D3H41_RS17635	COG0631	protein serine/threonine phosphatase activity
D3H41_RS17705	COG0420	3'-5' exonuclease activity
D3H41_RS17710	COG0419	ATPase involved in DNA repair
D3H41_RS17720	COG3040	lipid binding
D3H41_RS17730	COG1288	antiporter activity
D3H41_RS17740	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D3H41_RS17755	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D3H41_RS17770	COG0583	DNA-binding transcription factor activity
D3H41_RS17775	COG0277	FAD linked oxidase domain protein
D3H41_RS17790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3H41_RS17870	COG5001	Diguanylate cyclase
D3H41_RS17880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H41_RS17885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H41_RS17895	COG2116	formate transmembrane transporter activity
D3H41_RS17915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3H41_RS17955	COG3118	belongs to the thioredoxin family
D3H41_RS17960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H41_RS17985	COG2271	Major facilitator Superfamily
D3H41_RS17990	COG3851	Histidine kinase
D3H41_RS17995	COG2197	response regulator
D3H41_RS18005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3H41_RS18010	COG0583	DNA-binding transcription factor activity
D3H41_RS18020	COG0243	molybdopterin cofactor binding
D3H41_RS18035	COG0384	phenazine biosynthesis protein PhzF
D3H41_RS18040	COG1794	racemase activity, acting on amino acids and derivatives
D3H41_RS18070	COG1328	CTP reductase activity
D3H41_RS18075	COG0602	queuosine metabolic process
D3H41_RS18080	COG0534	Mate efflux family protein
D3H41_RS18085	COG2207	Transcriptional regulator
D3H41_RS18095	COG4067	protein conserved in archaea
D3H41_RS18095	COG0189	ligase activity
D3H41_RS18105	COG3111	PFAM Bacterial OB fold (BOF) protein
D3H41_RS18115	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3H41_RS18120	COG4149	molybdate abc transporter
D3H41_RS18125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3H41_RS18135	COG3706	GGDEF domain
D3H41_RS18135	COG4251	negative regulation of phosphorylation
D3H41_RS18135	COG5001	Diguanylate cyclase
D3H41_RS18135	COG2203	Gaf domain
D3H41_RS18155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3H41_RS18160	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3H41_RS18185	COG3140	Belongs to the UPF0181 family
D3H41_RS18200	COG0583	DNA-binding transcription factor activity
D3H41_RS18240	COG4128	Pfam Zonular occludens toxin
D3H41_RS18290	COG0023	Translation Initiation Factor
D3H41_RS18300	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3H41_RS18310	COG1042	CoA-binding domain protein
D3H41_RS18310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_RS18310	COG0045	succinate-CoA ligase (ADP-forming) activity
D3H41_RS18315	COG0583	DNA-binding transcription factor activity
D3H41_RS18335	COG5001	Diguanylate cyclase
D3H41_RS18335	COG5002	protein histidine kinase activity
D3H41_RS18335	COG3447	MASE1 domain protein
D3H41_RS18340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3H41_RS18345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3H41_RS18350	COG1984	allophanate hydrolase subunit 2
D3H41_RS18360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D3H41_RS18365	COG4181	ATPase activity
D3H41_RS18375	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3H41_RS18380	COG3300	MHYT domain
D3H41_RS18380	COG5001	Diguanylate cyclase
D3H41_RS18390	COG0484	heat shock protein binding
D3H41_RS18415	COG4533	DNA binding
D3H41_RS18425	COG2050	protein possibly involved in aromatic compounds catabolism
D3H41_RS18440	COG2067	long-chain fatty acid transport protein
D3H41_RS18445	COG2267	carboxylic ester hydrolase activity
D3H41_RS18470	COG0737	Belongs to the 5'-nucleotidase family
D3H41_RS18475	COG3593	DNA synthesis involved in DNA repair
D3H41_RS18485	COG0583	DNA-binding transcription factor activity
D3H41_RS18490	COG2116	formate transmembrane transporter activity
D3H41_RS18495	COG2353	YceI-like domain
D3H41_RS18500	COG3038	cytochrome b561
D3H41_RS18520	COG0513	Belongs to the DEAD box helicase family
D3H41_RS18525	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D3H41_RS18535	COG0840	transmembrane signaling receptor activity
D3H41_RS18545	COG0546	phosphoglycolate phosphatase activity
D3H41_RS18560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_RS18565	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D3H41_RS18570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3H41_RS18585	COG2207	Transcriptional regulator
D3H41_RS18590	COG1979	alcohol dehydrogenase
D3H41_RS18600	COG1126	abc transporter atp-binding protein
D3H41_RS18605	COG0765	amino acid transport
D3H41_RS18610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_RS18615	COG0765	amino acid transport
D3H41_RS18620	COG2200	EAL domain
D3H41_RS18620	COG2203	Gaf domain
D3H41_RS18620	COG2199	diguanylate cyclase activity
D3H41_RS18635	COG1609	Transcriptional regulator
D3H41_RS18640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_RS18640	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_RS18645	COG1105	Belongs to the carbohydrate kinase PfkB family
D3H41_RS18650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3H41_RS18650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3H41_RS18650	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D3H41_RS18680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3H41_RS18690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3H41_RS18695	COG0509	glycine decarboxylation via glycine cleavage system
D3H41_RS18705	COG0346	lactoylglutathione lyase activity
D3H41_RS18715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H41_RS18720	COG0583	DNA-binding transcription factor activity
D3H41_RS18725	COG0697	spore germination
D3H41_RS18730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3H41_RS18785	COG2176	DNA-directed DNA polymerase activity
D3H41_RS18830	COG0242	peptide deformylase activity
D3H41_RS18865	COG2239	Acts as a magnesium transporter
D3H41_RS18885	COG0346	lactoylglutathione lyase activity
D3H41_RS18890	COG1902	pentaerythritol trinitrate reductase activity
D3H41_RS18910	COG5642	Protein of unknown function (DUF2384)
D3H41_RS18915	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D3H41_RS18950	COG2076	Multidrug Resistance protein
D3H41_RS18970	COG2962	Rard protein
D3H41_RS18985	COG0835	chemotaxis
D3H41_RS18985	COG0784	Response regulator, receiver
D3H41_RS18995	COG2197	response regulator
D3H41_RS19005	COG3706	GGDEF domain
D3H41_RS19010	COG2197	response regulator
D3H41_RS19015	COG3300	MHYT domain
D3H41_RS19015	COG5001	Diguanylate cyclase
D3H41_RS19020	COG2205	protein histidine kinase activity
D3H41_RS19020	COG0784	Response regulator, receiver
D3H41_RS19025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D3H41_RS19045	COG1214	PFAM Peptidase M22, glycoprotease
D3H41_RS19045	COG0456	acetyltransferase
D3H41_RS19055	COG3069	C4-dicarboxylate transmembrane transporter activity
D3H41_RS19080	COG3111	PFAM Bacterial OB fold (BOF) protein
D3H41_RS19085	COG1597	lipid kinase activity
D3H41_RS19090	COG0583	DNA-binding transcription factor activity
D3H41_RS19125	COG0714	Associated with various cellular activities
D3H41_RS19130	COG0641	radical SAM
D3H41_RS19135	COG3119	arylsulfatase activity
D3H41_RS19145	COG3119	arylsulfatase activity
D3H41_RS19150	COG0745	RESPONSE REGULATOR receiver
D3H41_RS19165	COG2198	Histidine kinase
D3H41_RS19165	COG0784	Response regulator, receiver
D3H41_RS19165	COG2205	protein histidine kinase activity
D3H41_RS19170	COG1879	ABC-type sugar transport system periplasmic component
D3H41_RS19175	COG1803	Methylglyoxal synthase
D3H41_RS19180	COG0210	DNA helicase
D3H41_RS19185	COG1289	transmembrane transporter activity
D3H41_RS19220	COG4771	TonB-dependent receptor
D3H41_RS19220	COG1629	transport
D3H41_RS19230	COG0789	Transcriptional regulator
D3H41_RS19235	COG4604	ABC transporter, ATP-binding protein
D3H41_RS19240	COG4605	iron ion homeostasis
D3H41_RS19245	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H41_RS19250	COG4607	ABC-type enterochelin transport system periplasmic component
D3H41_RS19260	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D3H41_RS19275	COG1609	Transcriptional regulator
D3H41_RS19280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_RS19285	COG1879	ABC-type sugar transport system periplasmic component
D3H41_RS19290	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3H41_RS19295	COG1129	ABC transporter
D3H41_RS19300	COG1869	D-ribose catabolic process
D3H41_RS19305	COG5001	Diguanylate cyclase
D3H41_RS19365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3H41_RS19375	COG0784	Response regulator, receiver
D3H41_RS19375	COG2205	protein histidine kinase activity
D3H41_RS19390	COG0330	HflC and HflK could
D3H41_RS19405	COG0517	IMP dehydrogenase activity
D3H41_RS19405	COG4175	Glycine betaine
D3H41_RS19410	COG4176	ABC-type proline glycine betaine transport system permease component
D3H41_RS19425	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_RS19430	COG1309	transcriptional regulator
D3H41_RS19440	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS19455	COG1024	Enoyl-CoA hydratase
D3H41_RS19460	COG1960	acyl-CoA dehydrogenase activity
D3H41_RS19470	COG0183	Belongs to the thiolase family
D3H41_RS19480	COG1960	acyl-CoA dehydrogenase activity
D3H41_RS19485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3H41_RS19495	COG4770	biotin carboxylase activity
D3H41_RS19510	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3H41_RS19510	COG3264	Mechanosensitive ion channel
D3H41_RS19520	COG0110	maltose O-acetyltransferase activity
D3H41_RS19525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_RS19530	COG1271	oxidase subunit
D3H41_RS19535	COG1294	oxidase, subunit
D3H41_RS19550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H41_RS19560	COG3527	Alpha-acetolactate decarboxylase
D3H41_RS19575	COG0500	methyltransferase
D3H41_RS19605	COG1022	Amp-dependent synthetase and ligase
D3H41_RS19635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3H41_RS19640	COG1263	PTS System
D3H41_RS19640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_RS19645	COG1486	melibiose metabolic process
D3H41_RS19650	COG2188	Transcriptional regulator
D3H41_RS19655	COG1320	monovalent cation:proton antiporter activity
D3H41_RS19660	COG2212	antiporter activity
D3H41_RS19665	COG1863	multisubunit Na H antiporter MnhE subunit
D3H41_RS19670	COG0651	ATP synthesis coupled electron transport
D3H41_RS19675	COG1006	Multisubunit Na H antiporter MnhC subunit
D3H41_RS19680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3H41_RS19680	COG2111	Na H antiporter
D3H41_RS19690	COG0589	response to stress
D3H41_RS19695	COG4221	oxidoreductase activity
D3H41_RS19700	COG0583	DNA-binding transcription factor activity
D3H41_RS19710	COG2814	Major facilitator Superfamily
D3H41_RS19765	COG1522	sequence-specific DNA binding
D3H41_RS19800	COG0515	serine threonine protein kinase
D3H41_RS19825	COG3501	Rhs element vgr protein
D3H41_RS19865	COG0739	heme binding
D3H41_RS19880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_RS19925	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D3H41_RS19935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3H41_RS19935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3H41_RS19950	COG4989	oxidoreductase activity
D3H41_RS19965	COG0038	chloride channel
D3H41_RS20000	COG2897	thiosulfate sulfurtransferase activity
D3H41_RS20020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3H41_RS20025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3H41_RS20030	COG0840	transmembrane signaling receptor activity
D3H41_RS20035	COG2814	Major facilitator Superfamily
D3H41_RS20040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3H41_RS20055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H41_RS20065	COG0840	transmembrane signaling receptor activity
D3H41_RS20085	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3H41_RS20100	COG2197	response regulator
D3H41_RS20105	COG3850	Histidine kinase
D3H41_RS20110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3H41_RS20120	COG0243	molybdopterin cofactor binding
D3H41_RS20130	COG3005	denitrification pathway
D3H41_RS20140	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3H41_RS20150	COG0183	Belongs to the thiolase family
D3H41_RS20160	COG1280	lysine exporter protein (LysE YggA)
D3H41_RS20170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H41_RS20175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H41_RS20230	COG1846	Transcriptional regulator
D3H41_RS20235	COG2205	protein histidine kinase activity
D3H41_RS20235	COG0784	Response regulator, receiver
D3H41_RS20240	COG1879	ABC-type sugar transport system periplasmic component
D3H41_RS20250	COG2827	Endonuclease containing a URI domain
D3H41_RS20255	COG3132	Protein of unknown function, DUF480
D3H41_RS20275	COG2205	protein histidine kinase activity
D3H41_RS20275	COG0784	Response regulator, receiver
D3H41_RS20275	COG5002	protein histidine kinase activity
D3H41_RS20315	COG0531	amino acid
D3H41_RS20330	COG2205	protein histidine kinase activity
D3H41_RS20335	COG0745	RESPONSE REGULATOR receiver
D3H41_RS20360	COG1566	PFAM secretion protein HlyD family protein
D3H41_RS20365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3H41_RS20370	COG2239	Acts as a magnesium transporter
D3H41_RS20375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D3H41_RS20380	COG0402	S-adenosylhomocysteine deaminase activity
D3H41_RS20385	COG1418	mRNA catabolic process
D3H41_RS20400	COG2814	Major facilitator Superfamily
D3H41_RS20410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3H41_RS20430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3H41_RS20445	COG0745	RESPONSE REGULATOR receiver
D3H41_RS20450	COG2205	protein histidine kinase activity
D3H41_RS20460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D3H41_RS20465	COG2194	sulfuric ester hydrolase activity
D3H41_RS20485	COG4667	esterase of the alpha-beta hydrolase superfamily
D3H41_RS20490	COG1741	Belongs to the pirin family
D3H41_RS20495	COG1278	Cold shock
D3H41_RS20510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3H41_RS20515	COG0678	peroxiredoxin activity
D3H41_RS20515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3H41_RS20525	COG1686	Belongs to the peptidase S11 family
D3H41_RS20535	COG0625	glutathione transferase activity
D3H41_RS20545	COG1621	beta-fructofuranosidase activity
D3H41_RS20550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_RS20555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_RS20555	COG1263	PTS System
D3H41_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS20595	COG3746	phosphate-selective porin O and P
D3H41_RS20615	COG0583	DNA-binding transcription factor activity
D3H41_RS20620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3H41_RS20620	COG2207	Transcriptional regulator
D3H41_RS20625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_RS20650	COG0513	Belongs to the DEAD box helicase family
D3H41_RS20660	COG0583	DNA-binding transcription factor activity
D3H41_RS20675	COG1902	pentaerythritol trinitrate reductase activity
D3H41_RS20680	COG1063	alcohol dehydrogenase
D3H41_RS20690	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS20700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_RS20705	COG0006	proline dipeptidase activity
D3H41_RS20710	COG3608	succinylglutamate desuccinylase aspartoacylase
D3H41_RS20715	COG1522	sequence-specific DNA binding
D3H41_RS20720	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_RS20725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3H41_RS20730	COG3122	Protein conserved in bacteria
D3H41_RS20745	COG0583	DNA-binding transcription factor activity
D3H41_RS20750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3H41_RS20755	COG0252	asparaginase activity
D3H41_RS20760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D3H41_RS20775	COG2197	response regulator
D3H41_RS20780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3H41_RS20805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_RS20835	COG3842	ATPase activity
D3H41_RS20855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_RS20885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3H41_RS20890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3H41_RS20925	COG0583	DNA-binding transcription factor activity
D3H41_RS20935	COG4948	Mandelate Racemase Muconate Lactonizing
D3H41_RS20970	COG1342	Belongs to the UPF0251 family
D3H41_RS20980	COG4176	ABC-type proline glycine betaine transport system permease component
D3H41_RS20985	COG3448	diguanylate cyclase activity
D3H41_RS20985	COG4175	Glycine betaine
D3H41_RS20990	COG3015	lipoprotein NlpE involved in copper resistance
D3H41_RS20995	COG3713	MltA-interacting MipA family protein
D3H41_RS21010	COG0583	DNA-binding transcription factor activity
D3H41_RS21035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D3H41_RS21045	COG1335	isochorismatase
D3H41_RS21060	COG1349	DNA-binding transcription factor activity
D3H41_RS21065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_RS21065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_RS21070	COG2070	2-Nitropropane dioxygenase
D3H41_RS21075	COG0531	amino acid
D3H41_RS21080	COG4302	ethanolamine ammonia-lyase activity
D3H41_RS21085	COG4303	Ethanolamine ammonia lyase large subunit
D3H41_RS21095	COG1309	transcriptional regulator
D3H41_RS21115	COG1280	lysine exporter protein (LysE YggA)
D3H41_RS21125	COG0459	protein refolding
D3H41_RS21130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3H41_RS21140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H41_RS21155	COG1304	FMN binding
D3H41_RS21180	COG4786	Flagellar basal body rod
D3H41_RS21180	COG1256	bacterial-type flagellum assembly
D3H41_RS21190	COG1706	bacterial-type flagellum-dependent cell motility
D3H41_RS21195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3H41_RS21200	COG4786	Flagellar basal body rod
D3H41_RS21205	COG4787	bacterial-type flagellum-dependent cell motility
D3H41_RS21220	COG1558	bacterial-type flagellum-dependent cell motility
D3H41_RS21225	COG1815	bacterial-type flagellum-dependent cell motility
D3H41_RS21245	COG0741	lytic transglycosylase activity
D3H41_RS21250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3H41_RS21270	COG1760	l-serine dehydratase
D3H41_RS21285	COG0583	DNA-binding transcription factor activity
D3H41_RS21295	COG2866	Carboxypeptidase
D3H41_RS21300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H41_RS21310	COG2990	Protein conserved in bacteria
D3H41_RS21335	COG3842	ATPase activity
D3H41_RS21340	COG1840	ABC-type Fe3 transport system, periplasmic component
D3H41_RS21350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3H41_RS21360	COG1609	Transcriptional regulator
D3H41_RS21390	COG3240	lipase activity
D3H41_RS21395	COG1309	transcriptional regulator
D3H41_RS21410	COG0577	efflux transmembrane transporter activity
D3H41_RS21410	COG1136	(ABC) transporter
D3H41_RS21415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_RS21420	COG2067	long-chain fatty acid transport protein
D3H41_RS21430	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D3H41_RS21445	COG1011	Hydrolase
D3H41_RS21485	COG0110	maltose O-acetyltransferase activity
D3H41_RS21490	COG1765	OsmC-like protein
D3H41_RS21535	COG1765	OsmC-like protein
D3H41_RS21540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_RS21540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_RS21555	COG3046	protein related to deoxyribodipyrimidine photolyase
D3H41_RS21560	COG0415	Belongs to the DNA photolyase family
D3H41_RS21565	COG3706	GGDEF domain
D3H41_RS21580	COG3706	GGDEF domain
D3H41_RS21595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3H41_RS21615	COG3033	Beta-eliminating lyase
D3H41_RS21625	COG1271	oxidase subunit
D3H41_RS21630	COG1294	oxidase, subunit
D3H41_RS21655	COG0579	oxidoreductase
D3H41_RS21680	COG3706	GGDEF domain
D3H41_RS21710	COG0583	DNA-binding transcription factor activity
D3H41_RS21735	COG0189	ligase activity
D3H41_RS21740	COG0189	ligase activity
D3H41_RS21740	COG4067	protein conserved in archaea
D3H41_RS21750	COG1166	arginine decarboxylase activity
D3H41_RS21755	COG0010	Belongs to the arginase family
D3H41_RS21760	COG2814	Major facilitator Superfamily
D3H41_RS21765	COG1770	oligopeptidase
D3H41_RS21780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3H41_RS21785	COG1121	(ABC) transporter
D3H41_RS21790	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3H41_RS21835	COG0848	biopolymer transport protein
D3H41_RS21840	COG0811	peptide transport
D3H41_RS21845	COG0811	peptide transport
D3H41_RS21865	COG0745	RESPONSE REGULATOR receiver
D3H41_RS21870	COG0584	glycerophosphoryl diester phosphodiesterase
D3H41_RS21880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3H41_RS21945	COG0312	modulator of DNA gyrase
D3H41_RS21950	COG0312	modulator of DNA gyrase
D3H41_RS21955	COG0351	phosphomethylpyrimidine kinase
D3H41_RS21960	COG1116	anion transmembrane transporter activity
D3H41_RS21965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3H41_RS21970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3H41_RS21975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D3H41_RS21995	COG0243	molybdopterin cofactor binding
D3H41_RS22000	COG3005	denitrification pathway
D3H41_RS22005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_RS22010	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_RS22025	COG0456	acetyltransferase
D3H41_RS22045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_RS22050	COG1929	Belongs to the glycerate kinase type-1 family
D3H41_RS22055	COG2610	gluconate transmembrane transporter activity
D3H41_RS22060	COG3835	regulator
D3H41_RS22120	COG3047	cAMP biosynthetic process
D3H41_RS22125	COG1357	PFAM Pentapeptide repeats (8 copies)
D3H41_RS22155	COG2375	cellular response to nickel ion
D3H41_RS22160	COG0583	DNA-binding transcription factor activity
D3H41_RS22165	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D3H41_RS22170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D3H41_RS22185	COG2199	diguanylate cyclase activity
D3H41_RS22195	COG0561	phosphatase activity
D3H41_RS22200	COG0583	DNA-binding transcription factor activity
D3H41_RS22215	COG0564	pseudouridine synthase activity
D3H41_RS22220	COG0534	Mate efflux family protein
D3H41_RS22225	COG5001	Diguanylate cyclase
D3H41_RS22235	COG3123	guanosine phosphorylase activity
D3H41_RS22250	COG0596	Alpha beta hydrolase
D3H41_RS22275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D3H41_RS22285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3H41_RS22290	COG2169	Transcriptional regulator
D3H41_RS22290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3H41_RS22300	COG2259	Doxx family
D3H41_RS22305	COG1741	Belongs to the pirin family
D3H41_RS22325	COG0363	glucosamine-6-phosphate deaminase activity
D3H41_RS22335	COG0786	glutamate:sodium symporter activity
D3H41_RS22340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_RS22345	COG1131	(ABC) transporter
D3H41_RS22355	COG0786	glutamate:sodium symporter activity
D3H41_RS22380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3H41_RS22385	COG3279	Response regulator of the LytR AlgR family
D3H41_RS22390	COG3275	phosphorelay sensor kinase activity
D3H41_RS22420	COG0772	Belongs to the SEDS family
D3H41_RS22445	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D3H41_RS22445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3H41_RS22455	COG0444	Belongs to the ABC transporter superfamily
D3H41_RS22460	COG4608	Belongs to the ABC transporter superfamily
D3H41_RS22485	COG1444	tRNA N-acetyltransferase activity
D3H41_RS22505	COG3340	Belongs to the peptidase S51 family
D3H41_RS22510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3H41_RS22515	COG1263	PTS System
D3H41_RS22515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_RS22520	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D3H41_RS22530	COG1737	Transcriptional regulator
D3H41_RS22540	COG4166	transmembrane transport
D3H41_RS22585	COG0259	pyridoxamine-phosphate oxidase activity
D3H41_RS22610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H41_RS22650	COG1132	(ABC) transporter
D3H41_RS22660	COG0513	Belongs to the DEAD box helicase family
D3H41_RS22665	COG2258	MOSC domain
D3H41_RS22730	COG3634	alkyl hydroperoxide reductase activity
D3H41_RS22740	COG1846	Transcriptional regulator
D3H41_RS22745	COG1764	response to oxidative stress
D3H41_RS22775	COG0577	efflux transmembrane transporter activity
D3H41_RS22780	COG1136	(ABC) transporter
D3H41_RS22795	COG0463	Glycosyl transferase, family 2
D3H41_RS22815	COG0826	peptidase U32
D3H41_RS22845	COG1653	transport
D3H41_RS22850	COG0019	diaminopimelate decarboxylase activity
D3H41_RS22855	COG4264	IucA IucC family
D3H41_RS22880	COG4772	TonB-dependent receptor
D3H41_RS22885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D3H41_RS22890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H41_RS22895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H41_RS22900	COG1120	ATPase activity
D3H41_RS22905	COG0840	transmembrane signaling receptor activity
D3H41_RS22910	COG0612	Peptidase, M16
D3H41_RS22920	COG0739	heme binding
D3H41_RS22935	COG2814	Major facilitator Superfamily
D3H41_RS22945	COG1609	Transcriptional regulator
D3H41_RS22950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H41_RS22965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3H41_RS22965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3H41_RS22975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3H41_RS22980	COG1609	Transcriptional regulator
D3H41_RS22990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3H41_RS23030	COG1760	l-serine dehydratase
D3H41_RS23040	COG4580	involved in the transport of maltose and maltodextrins
D3H41_RS23065	COG2356	endonuclease I
D3H41_RS23085	COG1982	Orn Lys Arg decarboxylase major
D3H41_RS23090	COG0531	amino acid
D3H41_RS23100	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3H41_RS23105	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D3H41_RS23110	COG1162	GTPase activity
D3H41_RS23115	COG1263	PTS System
D3H41_RS23115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_RS23120	COG1999	signal sequence binding
D3H41_RS23135	COG2909	trisaccharide binding
D3H41_RS23140	COG0058	SHG alpha-glucan phosphorylase activity
D3H41_RS23145	COG1640	4-alpha-glucanotransferase
D3H41_RS23150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3H41_RS23155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3H41_RS23160	COG0366	Alpha amylase catalytic
D3H41_RS23175	COG3366	ferrous iron transmembrane transporter activity
D3H41_RS23180	COG0700	Nucleoside recognition
D3H41_RS23185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3H41_RS23190	COG3339	Conserved Protein
D3H41_RS23205	COG1301	dicarboxylic acid transport
D3H41_RS23215	COG0583	DNA-binding transcription factor activity
D3H41_RS23250	COG2095	MarC family integral membrane protein
D3H41_RS23255	COG4667	esterase of the alpha-beta hydrolase superfamily
D3H41_RS23260	COG3397	chitin binding
D3H41_RS23265	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D3H41_RS23270	COG0415	Belongs to the DNA photolyase family
D3H41_RS23280	COG1054	Belongs to the UPF0176 family
D3H41_RS23290	COG1686	Belongs to the peptidase S11 family
D3H41_RS23315	COG0583	DNA-binding transcription factor activity
D3H41_RS23320	COG4628	conserved protein (DUF2132)
D3H41_RS23340	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D3H41_RS23345	COG0628	permease
D3H41_RS23390	COG2814	Major facilitator Superfamily
D3H41_RS23405	COG0454	-acetyltransferase
D3H41_RS23415	COG0745	RESPONSE REGULATOR receiver
D3H41_RS23420	COG2205	protein histidine kinase activity
D3H41_RS23440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3H41_RS23445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3H41_RS23450	COG1882	Formate acetyltransferase
D3H41_RS23485	COG1360	Flagellar Motor Protein
D3H41_RS23490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3H41_RS23495	COG1191	sigma factor activity
D3H41_RS23500	COG1580	Controls the rotational direction of flagella during chemotaxis
D3H41_RS23520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D3H41_RS23530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_RS23545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3H41_RS23555	COG1987	bacterial-type flagellum assembly
D3H41_RS23595	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3H41_RS23655	COG0346	lactoylglutathione lyase activity
D3H41_RS23680	COG0745	RESPONSE REGULATOR receiver
D3H41_RS23705	COG3300	MHYT domain
D3H41_RS23705	COG5001	Diguanylate cyclase
D3H41_RS23710	COG0156	8-amino-7-oxononanoate synthase activity
D3H41_RS23715	COG1063	alcohol dehydrogenase
D3H41_RS23750	COG0668	transmembrane transport
D3H41_RS23760	COG1304	FMN binding
D3H41_RS23765	COG1620	l-lactate permease
D3H41_RS23770	COG0583	DNA-binding transcription factor activity
D3H41_RS23775	COG1505	serine-type exopeptidase activity
D3H41_RS23780	COG4172	Belongs to the ABC transporter superfamily
D3H41_RS23790	COG1067	ATP-dependent peptidase activity
D3H41_RS23800	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3H41_RS23820	COG1247	-acetyltransferase
D3H41_RS23825	COG0437	4 iron, 4 sulfur cluster binding
D3H41_RS23830	COG0348	domain, Protein
D3H41_RS23850	COG1122	ATPase activity
D3H41_RS23855	COG4720	Psort location CytoplasmicMembrane, score
D3H41_RS23860	COG1566	PFAM secretion protein HlyD family protein
D3H41_RS23885	COG0813	purine-nucleoside phosphorylase activity
D3H41_RS23890	COG3272	Protein of unknown function (DUF1722)
D3H41_RS23895	COG0789	Transcriptional regulator
D3H41_RS23900	COG0415	Belongs to the DNA photolyase family
D3H41_RS23905	COG1376	ErfK ybiS ycfS ynhG family protein
D3H41_RS23905	COG1388	LysM domain
D3H41_RS23915	COG0513	Belongs to the DEAD box helicase family
D3H41_RS23920	COG1770	oligopeptidase
D3H41_RS23925	COG4771	TonB-dependent receptor
D3H41_RS23955	COG0573	inorganic phosphate transmembrane transporter activity
D3H41_RS23960	COG0581	inorganic phosphate transmembrane transporter activity
D3H41_RS23965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3H41_RS23985	COG2304	oxidoreductase activity
D3H41_RS24005	COG0714	Associated with various cellular activities
D3H41_RS24020	COG2197	response regulator
D3H41_RS24055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D3H41_RS24060	COG1120	ATPase activity
D3H41_RS24065	COG4774	siderophore transport
D3H41_RS24070	COG1132	(ABC) transporter
D3H41_RS24075	COG2205	protein histidine kinase activity
D3H41_RS24085	COG0569	domain protein
D3H41_RS24090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3H41_RS24095	COG0583	DNA-binding transcription factor activity
D3H41_RS24110	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_RS24115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H41_RS24120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H41_RS24130	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D3H41_RS24135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H41_RS24165	COG2084	Dehydrogenase
D3H41_RS24170	COG0753	catalase activity
D3H41_RS24180	COG2130	NADP-dependent
D3H41_RS24185	COG1309	transcriptional regulator
D3H41_RS24190	COG3097	Belongs to the UPF0267 family
D3H41_RS24230	COG3206	protein involved in exopolysaccharide biosynthesis
D3H41_RS24230	COG0489	protein tyrosine kinase activity
D3H41_RS24245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H41_RS24250	COG3842	ATPase activity
D3H41_RS24260	COG1175	transmembrane transport
D3H41_RS24265	COG3833	ABC-type maltose transport systems, permease component
D3H41_RS24295	COG2354	Protein conserved in bacteria
D3H41_RS24300	COG0418	dihydroorotase activity
D3H41_RS24310	COG0401	homolog of Blt101
D3H41_RS24315	COG0633	Ferredoxin
D3H41_RS24315	COG3217	Mosc domain protein beta barrel domain protein
D3H41_RS24315	COG0633	Ferredoxin
D3H41_RS24315	COG3217	Mosc domain protein beta barrel domain protein
D3H41_RS24325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3H41_RS24365	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D3H41_RS24370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H41_RS24380	COG0848	biopolymer transport protein
D3H41_RS24385	COG0811	peptide transport
D3H41_RS24390	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D3H41_RS24400	COG3721	Heme iron utilization protein
D3H41_RS24405	COG0748	coenzyme F420 binding
D3H41_RS24415	COG0784	Response regulator, receiver
D3H41_RS24415	COG0835	chemotaxis
D3H41_RS24420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3H41_RS24425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3H41_RS24455	COG0534	Mate efflux family protein
D3H41_RS24460	COG0444	Belongs to the ABC transporter superfamily
D3H41_RS24465	COG4608	Belongs to the ABC transporter superfamily
D3H41_RS24470	COG0747	negative chemotaxis
D3H41_RS24480	COG1349	DNA-binding transcription factor activity
D3H41_RS24485	COG2084	Dehydrogenase
D3H41_RS24490	COG3395	kinase activity
D3H41_RS24495	COG0235	Class ii aldolase
D3H41_RS24500	COG3622	Belongs to the hyi family
D3H41_RS24505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3H41_RS24510	COG2610	gluconate transmembrane transporter activity
D3H41_RS24530	COG0583	DNA-binding transcription factor activity
D3H41_RS24535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3H41_RS24545	COG4934	collagen metabolic process
D3H41_RS24555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3H41_RS24560	COG0789	Transcriptional regulator
D3H41_RS24565	COG0366	Alpha amylase catalytic
D3H41_RS24585	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3H41_RS24590	COG0589	response to stress
D3H41_RS24595	COG0488	(ABC) transporter
D3H41_RS24600	COG1505	serine-type exopeptidase activity
D3H41_RS24610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_RS24630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_RS24655	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_RS24675	COG3383	formate dehydrogenase (NAD+) activity
D3H41_RS24685	COG0842	Transport permease protein
D3H41_RS24690	COG1131	(ABC) transporter
D3H41_RS24705	COG1881	PFAM PEBP family protein
D3H41_RS24715	COG0798	PFAM Bile acid sodium symporter
D3H41_RS24730	COG1733	regulation of RNA biosynthetic process
D3H41_RS24755	COG4989	oxidoreductase activity
D3H41_RS24780	COG0814	amino acid
D3H41_RS24795	COG3314	Sporulation integral membrane protein YlbJ
D3H41_RS24820	COG0739	heme binding
D3H41_RS24825	COG5001	Diguanylate cyclase
D3H41_RS24830	COG0583	DNA-binding transcription factor activity
D3H41_RS24835	COG2814	Major facilitator Superfamily
D3H41_RS24855	COG0697	spore germination
D3H41_RS24870	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3H41_RS24890	COG1280	lysine exporter protein (LysE YggA)
D3H41_RS24900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H41_RS24905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3H41_RS24910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3H41_RS24915	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D3H41_RS24920	COG1845	cytochrome c oxidase, subunit III
D3H41_RS24940	COG1612	heme a metabolic process
D3H41_RS24945	COG0109	protoheme IX farnesyltransferase activity
D3H41_RS24950	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H41_RS24980	COG1278	Cold shock
D3H41_RS24985	COG3036	rescue of stalled ribosome
D3H41_RS24990	COG2199	diguanylate cyclase activity
D3H41_RS25005	COG1132	(ABC) transporter
D3H41_RS25005	COG2375	cellular response to nickel ion
D3H41_RS25015	COG1538	Outer membrane efflux protein
D3H41_RS25020	COG2205	protein histidine kinase activity
D3H41_RS25020	COG0784	Response regulator, receiver
D3H41_RS25045	COG0840	transmembrane signaling receptor activity
D3H41_RS25050	COG0783	Belongs to the Dps family
D3H41_RS25060	COG2133	pyrroloquinoline quinone binding
D3H41_RS25065	COG1454	alcohol dehydrogenase
D3H41_RS25070	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D3H41_RS25090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H41_RS25095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3H41_RS25100	COG3186	Phenylalanine-4-hydroxylase
D3H41_RS25125	COG3530	Putative quorum-sensing-regulated virulence factor
D3H41_RS25140	COG2186	Transcriptional regulator
D3H41_RS25155	COG1279	arginine transmembrane transporter activity