locus-tag	class	description
D0812_RS00015	COG0592	DNA-directed DNA polymerase activity
D0812_RS00025	COG0187	DNA topoisomerase II activity
D0812_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
D0812_RS00035	COG3977	Valine--pyruvate aminotransferase
D0812_RS00055	COG4964	Belongs to the GSP D family
D0812_RS00120	COG0366	Alpha amylase catalytic
D0812_RS00135	COG2119	membrane
D0812_RS00145	COG0425	Belongs to the sulfur carrier protein TusA family
D0812_RS00160	COG0604	alcohol dehydrogenase
D0812_RS00165	COG0183	Belongs to the thiolase family
D0812_RS00175	COG1739	Uncharacterized protein family UPF0029
D0812_RS00180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0812_RS00225	COG2132	Multicopper oxidase
D0812_RS00245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0812_RS00250	COG2104	thiamine diphosphate biosynthetic process
D0812_RS00265	COG0006	proline dipeptidase activity
D0812_RS00265	COG0006	proline dipeptidase activity
D0812_RS00275	COG2814	Major facilitator Superfamily
D0812_RS00295	COG3220	belongs to the UPF0276 family
D0812_RS00305	COG0210	DNA helicase
D0812_RS00315	COG0405	Gamma-glutamyltransferase
D0812_RS00320	COG1280	lysine exporter protein (LysE YggA)
D0812_RS00330	COG2962	Rard protein
D0812_RS00335	COG0514	ATP-dependent DNA helicase (RecQ)
D0812_RS00350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0812_RS00370	COG3118	belongs to the thioredoxin family
D0812_RS00385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0812_RS00390	COG0633	Ferredoxin
D0812_RS00440	COG2959	enzyme of heme biosynthesis
D0812_RS00445	COG1587	Uroporphyrinogen-III synthase
D0812_RS00455	COG3072	Adenylate cyclase
D0812_RS00470	COG0019	diaminopimelate decarboxylase activity
D0812_RS00490	COG1011	Hydrolase
D0812_RS00495	COG3287	FIST C domain
D0812_RS00495	COG2200	EAL domain
D0812_RS00495	COG2199	diguanylate cyclase activity
D0812_RS00500	COG3148	PFAM DTW domain containing protein
D0812_RS00515	COG0561	phosphatase activity
D0812_RS00520	COG2267	carboxylic ester hydrolase activity
D0812_RS00525	COG1280	lysine exporter protein (LysE YggA)
D0812_RS00530	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0812_RS00535	COG0640	Transcriptional regulator
D0812_RS00540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0812_RS00595	COG2095	MarC family integral membrane protein
D0812_RS00605	COG0742	ribosomal rna small subunit methyltransferase
D0812_RS00610	COG0552	protein localization to endoplasmic reticulum
D0812_RS00610	COG0552	protein localization to endoplasmic reticulum
D0812_RS00615	COG2884	Cell division ATP-binding protein ftsE
D0812_RS00620	COG2177	Part of the ABC transporter FtsEX involved in
D0812_RS00635	COG0705	Rhomboid family
D0812_RS00640	COG1580	Controls the rotational direction of flagella during chemotaxis
D0812_RS00645	COG3161	chorismate lyase activity
D0812_RS00655	COG2937	Belongs to the GPAT DAPAT family
D0812_RS00675	COG0534	Mate efflux family protein
D0812_RS00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0812_RS00780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0812_RS00790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0812_RS00835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0812_RS00840	COG0250	Participates in transcription elongation, termination and antitermination
D0812_RS00845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0812_RS00855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0812_RS00860	COG0222	ribosome binding
D0812_RS00880	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D0812_RS00885	COG2816	NAD+ diphosphatase activity
D0812_RS00895	COG1573	uracil-dna glycosylase
D0812_RS00905	COG3068	Protein conserved in bacteria
D0812_RS00910	COG1253	flavin adenine dinucleotide binding
D0812_RS00925	COG0151	Belongs to the GarS family
D0812_RS00935	COG0789	Transcriptional regulator
D0812_RS00940	COG3710	Transcriptional regulator
D0812_RS00950	COG0531	amino acid
D0812_RS00955	COG1982	Orn Lys Arg decarboxylase major
D0812_RS01000	COG2199	diguanylate cyclase activity
D0812_RS01005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D0812_RS01010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0812_RS01025	COG0439	Biotin carboxylase
D0812_RS01030	COG0511	ligase activity, forming carbon-carbon bonds
D0812_RS01035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0812_RS01040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0812_RS01055	COG2814	Major facilitator Superfamily
D0812_RS01060	COG0784	Response regulator, receiver
D0812_RS01060	COG2205	protein histidine kinase activity
D0812_RS01060	COG2198	Histidine kinase
D0812_RS01080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_RS01090	COG2095	MarC family integral membrane protein
D0812_RS01100	COG4232	protein-disulfide reductase activity
D0812_RS01105	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0812_RS01110	COG1027	Aspartate ammonia-lyase
D0812_RS01115	COG3030	protein affecting phage T7 exclusion by the F plasmid
D0812_RS01120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0812_RS01130	COG2205	protein histidine kinase activity
D0812_RS01135	COG0745	RESPONSE REGULATOR receiver
D0812_RS01140	COG3678	ATP-independent chaperone mediated protein folding
D0812_RS01145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D0812_RS01155	COG0534	Mate efflux family protein
D0812_RS01180	COG1509	lysine 2,3-aminomutase activity
D0812_RS01185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0812_RS01210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0812_RS01215	COG1053	succinate dehydrogenase
D0812_RS01240	COG4942	peptidase
D0812_RS01245	COG1045	serine acetyltransferase
D0812_RS01255	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D0812_RS01260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0812_RS01265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D0812_RS01275	COG0840	transmembrane signaling receptor activity
D0812_RS01280	COG0471	metal ion transport
D0812_RS01295	COG1162	GTPase activity
D0812_RS01300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D0812_RS01375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0812_RS01380	COG0802	atpase or kinase
D0812_RS01385	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0812_RS01390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D0812_RS01405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0812_RS01410	COG0330	HflC and HflK could
D0812_RS01415	COG0330	HflC and HflK could
D0812_RS01420	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D0812_RS01425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0812_RS01435	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0812_RS01440	COG1017	nitric oxide dioxygenase activity
D0812_RS01440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0812_RS01450	COG0557	exoribonuclease II activity
D0812_RS01455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0812_RS01460	COG0546	phosphoglycolate phosphatase activity
D0812_RS01475	COG0512	Glutamine amidotransferase of anthranilate synthase
D0812_RS01480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0812_RS01500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0812_RS01505	COG3954	Phosphoribulokinase
D0812_RS01515	COG0429	hydrolase of the alpha beta-hydrolase fold
D0812_RS01525	COG0488	(ABC) transporter
D0812_RS01535	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0812_RS01550	COG1047	Peptidyl-prolyl cis-trans
D0812_RS01560	COG1446	asparaginase
D0812_RS01575	COG0545	Peptidyl-prolyl cis-trans isomerase
D0812_RS01580	COG2964	Protein conserved in bacteria
D0812_RS01585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D0812_RS01590	COG2923	Belongs to the DsrF TusC family
D0812_RS01595	COG2168	tRNA wobble position uridine thiolation
D0812_RS01610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0812_RS01620	COG2906	2 iron, 2 sulfur cluster binding
D0812_RS01630	COG0281	malic enzyme
D0812_RS01640	COG0626	cystathionine gamma-synthase activity
D0812_RS01645	COG0460	homoserine dehydrogenase
D0812_RS01645	COG0527	aspartate kinase activity
D0812_RS01650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0812_RS01660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0812_RS01670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0812_RS01685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0812_RS01685	COG0165	Argininosuccinate lyase
D0812_RS01700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0812_RS01705	COG0678	peroxiredoxin activity
D0812_RS01705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0812_RS01715	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D0812_RS01760	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0812_RS01765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0812_RS01775	COG2965	DNA replication, synthesis of RNA primer
D0812_RS01795	COG0305	Participates in initiation and elongation during chromosome replication
D0812_RS01800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0812_RS01810	COG0432	Pfam Uncharacterised protein family UPF0047
D0812_RS01825	COG0735	belongs to the Fur family
D0812_RS01830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0812_RS01850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0812_RS01920	COG0646	methionine synthase
D0812_RS01920	COG1410	methionine synthase
D0812_RS01925	COG0527	aspartate kinase activity
D0812_RS01935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0812_RS01945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0812_RS01960	COG0629	single-stranded DNA binding
D0812_RS01965	COG2199	diguanylate cyclase activity
D0812_RS01965	COG2200	EAL domain
D0812_RS01990	COG3409	Peptidoglycan-binding domain 1 protein
D0812_RS01990	COG3267	Type II secretory pathway component ExeA
D0812_RS02000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0812_RS02005	COG1459	type II secretion system
D0812_RS02015	COG2165	general secretion pathway protein
D0812_RS02055	COG1077	Cell shape determining protein MreB Mrl
D0812_RS02060	COG1792	Involved in formation and maintenance of cell shape
D0812_RS02065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D0812_RS02070	COG0424	maF-like protein
D0812_RS02080	COG3164	Protein of unknown function
D0812_RS02085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0812_RS02090	COG0312	modulator of DNA gyrase
D0812_RS02095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0812_RS02110	COG0564	pseudouridine synthase activity
D0812_RS02115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0812_RS02120	COG3028	Belongs to the UPF0307 family
D0812_RS02125	COG0312	modulator of DNA gyrase
D0812_RS02130	COG2239	Acts as a magnesium transporter
D0812_RS02135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS02145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS02150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0812_RS02160	COG1137	ATPase activity
D0812_RS02165	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D0812_RS02175	COG0517	IMP dehydrogenase activity
D0812_RS02175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0812_RS02185	COG1127	ABC transporter
D0812_RS02190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0812_RS02195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0812_RS02200	COG2854	intermembrane phospholipid transfer
D0812_RS02210	COG5007	Belongs to the BolA IbaG family
D0812_RS02220	COG0204	Acyl-transferase
D0812_RS02225	COG0251	oxidation-reduction process
D0812_RS02275	COG0525	valine-tRNA ligase activity
D0812_RS02280	COG2927	DNA polymerase III (CHI subunit)
D0812_RS02290	COG0795	lipopolysaccharide-transporting ATPase activity
D0812_RS02295	COG0795	lipopolysaccharide-transporting ATPase activity
D0812_RS02305	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS02315	COG0726	polysaccharide deacetylase
D0812_RS02320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0812_RS02330	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0812_RS02335	COG1486	melibiose metabolic process
D0812_RS02345	COG1609	Transcriptional regulator
D0812_RS02350	COG3437	response regulator, receiver
D0812_RS02400	COG1012	belongs to the aldehyde dehydrogenase family
D0812_RS02500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0812_RS02505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0812_RS02520	COG0762	integral membrane protein
D0812_RS02525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0812_RS02530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0812_RS02545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0812_RS02550	COG1678	Uncharacterized ACR, COG1678
D0812_RS02555	COG0189	ligase activity
D0812_RS02560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0812_RS02565	COG2356	endonuclease I
D0812_RS02585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0812_RS02605	COG0191	fructose-bisphosphate aldolase activity
D0812_RS02610	COG0668	transmembrane transport
D0812_RS02625	COG0583	DNA-binding transcription factor activity
D0812_RS02635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0812_RS02645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0812_RS02655	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D0812_RS02670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0812_RS02675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0812_RS02695	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D0812_RS02705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0812_RS02715	COG1595	DNA-templated transcription, initiation
D0812_RS02730	COG3086	response to oxidative stress
D0812_RS02750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0812_RS02755	COG1381	Involved in DNA repair and RecF pathway recombination
D0812_RS02760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D0812_RS02785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0812_RS02790	COG3956	TIGRFAM MazG family protein
D0812_RS02800	COG0148	phosphopyruvate hydratase activity
D0812_RS02810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0812_RS02840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0812_RS02850	COG1546	Belongs to the CinA family
D0812_RS02855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0812_RS02870	COG0527	aspartate kinase activity
D0812_RS02960	COG3630	sodium ion export across plasma membrane
D0812_RS02965	COG5016	pyruvate
D0812_RS02965	COG0511	ligase activity, forming carbon-carbon bonds
D0812_RS02970	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D0812_RS02980	COG1238	metal cluster binding
D0812_RS02985	COG0612	Peptidase, M16
D0812_RS03005	COG4536	flavin adenine dinucleotide binding
D0812_RS03010	COG4137	Cytochrome C assembly protein
D0812_RS03015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0812_RS03020	COG0228	four-way junction DNA binding
D0812_RS03035	COG0335	large ribosomal subunit rRNA binding
D0812_RS03040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D0812_RS03045	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D0812_RS03050	COG0237	dephospho-CoA kinase activity
D0812_RS03060	COG1459	type II secretion system
D0812_RS03065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0812_RS03090	COG2186	Transcriptional regulator
D0812_RS03095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0812_RS03100	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0812_RS03105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0812_RS03120	COG0288	reversible hydration of carbon dioxide
D0812_RS03125	COG0659	secondary active sulfate transmembrane transporter activity
D0812_RS03130	COG1131	(ABC) transporter
D0812_RS03135	COG0842	Transport permease protein
D0812_RS03140	COG1560	Kdo2-lipid A biosynthetic process
D0812_RS03155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0812_RS03165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0812_RS03180	COG1643	Atp-dependent helicase
D0812_RS03185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0812_RS03190	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0812_RS03195	COG1049	propionate catabolic process, 2-methylcitrate cycle
D0812_RS03210	COG0004	ammonium transporteR
D0812_RS03215	COG1840	ABC-type Fe3 transport system, periplasmic component
D0812_RS03225	COG3842	ATPase activity
D0812_RS03230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0812_RS03245	COG2971	BadF BadG BcrA BcrD
D0812_RS03255	COG4608	Belongs to the ABC transporter superfamily
D0812_RS03260	COG0444	Belongs to the ABC transporter superfamily
D0812_RS03265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0812_RS03275	COG0747	negative chemotaxis
D0812_RS03280	COG0784	Response regulator, receiver
D0812_RS03280	COG2205	protein histidine kinase activity
D0812_RS03295	COG0628	permease
D0812_RS03320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_RS03325	COG0739	heme binding
D0812_RS03330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0812_RS03340	COG2027	D-alanyl-D-alanine carboxypeptidase
D0812_RS03345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0812_RS03350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0812_RS03355	COG1534	Rna-binding protein
D0812_RS03365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0812_RS03370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0812_RS03380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0812_RS03400	COG0195	Participates in both transcription termination and antitermination
D0812_RS03420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0812_RS03440	COG0534	Mate efflux family protein
D0812_RS03445	COG0826	peptidase U32
D0812_RS03450	COG0826	peptidase U32
D0812_RS03460	COG3154	lipid carrier protein
D0812_RS03465	COG3153	acetyltransferase
D0812_RS03485	COG3706	GGDEF domain
D0812_RS03495	COG0084	hydrolase, TatD family'
D0812_RS03500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0812_RS03510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D0812_RS03520	COG0813	purine-nucleoside phosphorylase activity
D0812_RS03530	COG0560	Phosphoserine phosphatase
D0812_RS03540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D0812_RS03545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0812_RS03550	COG0583	DNA-binding transcription factor activity
D0812_RS03585	COG1022	Amp-dependent synthetase and ligase
D0812_RS03590	COG0741	lytic transglycosylase activity
D0812_RS03615	COG4964	Belongs to the GSP D family
D0812_RS03675	COG0583	DNA-binding transcription factor activity
D0812_RS03680	COG3408	Glycogen debranching enzyme
D0812_RS03680	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0812_RS03690	COG0531	amino acid
D0812_RS03695	COG2731	YhcH YjgK YiaL family protein
D0812_RS03700	COG3250	beta-galactosidase activity
D0812_RS03705	COG1609	Transcriptional regulator
D0812_RS03710	COG0768	penicillin binding
D0812_RS03715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0812_RS03720	COG1085	galactose-1-phosphate uridylyltransferase
D0812_RS03730	COG2017	converts alpha-aldose to the beta-anomer
D0812_RS03740	COG1609	Transcriptional regulator
D0812_RS03745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS03745	COG1263	PTS System
D0812_RS03755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0812_RS03775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0812_RS03780	COG1349	DNA-binding transcription factor activity
D0812_RS03790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0812_RS03800	COG2271	Major facilitator Superfamily
D0812_RS03805	COG0584	glycerophosphoryl diester phosphodiesterase
D0812_RS03820	COG2171	N-acyltransferase activity
D0812_RS03835	COG3141	response to X-ray
D0812_RS03855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D0812_RS03860	COG1074	ATP-dependent DNA helicase activity
D0812_RS03865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0812_RS03880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0812_RS03880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0812_RS03895	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D0812_RS03900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0812_RS03905	COG2166	iron-sulfur cluster assembly
D0812_RS03910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0812_RS03915	COG0693	protein deglycase activity
D0812_RS03920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0812_RS03925	COG3248	Nucleoside-binding outer membrane protein
D0812_RS03945	COG1595	DNA-templated transcription, initiation
D0812_RS03975	COG0271	Belongs to the BolA IbaG family
D0812_RS04000	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0812_RS04010	COG1477	protein flavinylation
D0812_RS04025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0812_RS04030	COG0514	ATP-dependent DNA helicase (RecQ)
D0812_RS04035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0812_RS04050	COG0733	neurotransmitter:sodium symporter activity
D0812_RS04075	COG1720	tRNA m6t6A37 methyltransferase activity
D0812_RS04090	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0812_RS04125	COG3098	single-species biofilm formation
D0812_RS04130	COG0564	pseudouridine synthase activity
D0812_RS04145	COG0024	Methionine aminopeptidase
D0812_RS04170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0812_RS04175	COG0575	Belongs to the CDS family
D0812_RS04185	COG0750	zinc metalloprotease
D0812_RS04195	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D0812_RS04200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0812_RS04225	COG0587	DNA-directed DNA polymerase activity
D0812_RS04245	COG0347	Belongs to the P(II) protein family
D0812_RS04260	COG0741	lytic transglycosylase activity
D0812_RS04260	COG1388	LysM domain
D0812_RS04270	COG2226	methyltransferase
D0812_RS04280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0812_RS04300	COG1960	acyl-CoA dehydrogenase activity
D0812_RS04305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D0812_RS04310	COG0121	glutamine amidotransferase
D0812_RS04315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0812_RS04320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0812_RS04325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0812_RS04330	COG2233	PERMEase
D0812_RS04350	COG1393	Belongs to the ArsC family
D0812_RS04355	COG4783	chaperone-mediated protein folding
D0812_RS04370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0812_RS04375	COG2716	regulation of RNA biosynthetic process
D0812_RS04380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0812_RS04385	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D0812_RS04405	COG1393	Belongs to the ArsC family
D0812_RS04430	COG2837	iron assimilation
D0812_RS04435	COG2169	Transcriptional regulator
D0812_RS04440	COG1486	melibiose metabolic process
D0812_RS04455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_RS04465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_RS04470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_RS04475	COG1334	flagellar protein FlaG
D0812_RS04480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0812_RS04490	COG1516	flagellar protein fliS
D0812_RS04510	COG1677	Flagellar hook-basal body complex protein FliE
D0812_RS04520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0812_RS04575	COG1987	bacterial-type flagellum assembly
D0812_RS04580	COG1684	flagellar biosynthetic protein fliR
D0812_RS04615	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D0812_RS04620	COG0643	Histidine kinase
D0812_RS04620	COG2198	Histidine kinase
D0812_RS04620	COG0784	Response regulator, receiver
D0812_RS04625	COG2201	protein-glutamate methylesterase activity
D0812_RS04630	COG1192	Involved in chromosome partitioning
D0812_RS04640	COG0835	chemotaxis
D0812_RS04650	COG4133	protoheme IX ABC transporter activity
D0812_RS04655	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0812_RS04660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0812_RS04675	COG1138	Cytochrome C-type biogenesis protein
D0812_RS04680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0812_RS04690	COG3088	subunit of a heme lyase
D0812_RS04690	COG4235	cytochrome complex assembly
D0812_RS04695	COG2853	Lipoprotein
D0812_RS04700	COG2067	long-chain fatty acid transport protein
D0812_RS04705	COG2067	long-chain fatty acid transport protein
D0812_RS04720	COG0183	Belongs to the thiolase family
D0812_RS04735	COG2062	phosphohistidine phosphatase, SixA
D0812_RS04740	COG2840	Smr protein MutS2
D0812_RS04745	COG2890	protein-(glutamine-N5) methyltransferase activity
D0812_RS04755	COG2860	membrane
D0812_RS04760	COG3101	peptidyl-lysine hydroxylation
D0812_RS04785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0812_RS04795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0812_RS04800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0812_RS04825	COG0285	dihydrofolate synthase activity
D0812_RS04830	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D0812_RS04835	COG1286	toxin biosynthetic process
D0812_RS04840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D0812_RS04845	COG0583	DNA-binding transcription factor activity
D0812_RS04850	COG0745	RESPONSE REGULATOR receiver
D0812_RS04860	COG2832	Protein of unknown function (DUF454)
D0812_RS04870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0812_RS04880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0812_RS04885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0812_RS04890	COG0814	amino acid
D0812_RS04895	COG0251	oxidation-reduction process
D0812_RS04905	COG2964	Protein conserved in bacteria
D0812_RS04920	COG2983	Belongs to the UPF0260 family
D0812_RS04925	COG2261	transglycosylase associated protein
D0812_RS04930	COG2985	domain, Protein
D0812_RS04935	COG0076	glutamate decarboxylase activity
D0812_RS04940	COG0668	transmembrane transport
D0812_RS04950	COG0346	lactoylglutathione lyase activity
D0812_RS04960	COG1785	Belongs to the alkaline phosphatase family
D0812_RS04975	COG2226	methyltransferase
D0812_RS05000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0812_RS05005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_RS05015	COG3139	Protein of unknown function (DUF1315)
D0812_RS05020	COG0252	asparaginase activity
D0812_RS05025	COG0616	signal peptide processing
D0812_RS05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0812_RS05030	COG1902	pentaerythritol trinitrate reductase activity
D0812_RS05035	COG0778	Nitroreductase
D0812_RS05040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0812_RS05055	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0812_RS05060	COG4269	membrane
D0812_RS05075	COG3083	sulfuric ester hydrolase activity
D0812_RS05100	COG1757	Na H antiporter
D0812_RS05105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0812_RS05110	COG2165	general secretion pathway protein
D0812_RS05115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0812_RS05120	COG2095	MarC family integral membrane protein
D0812_RS05125	COG1012	belongs to the aldehyde dehydrogenase family
D0812_RS05125	COG1454	alcohol dehydrogenase
D0812_RS05145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0812_RS05150	COG4974	Belongs to the 'phage' integrase family
D0812_RS05205	COG2885	chlorophyll binding
D0812_RS05205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0812_RS05215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0812_RS05215	COG2885	chlorophyll binding
D0812_RS05260	COG2003	Belongs to the UPF0758 family
D0812_RS05330	COG3504	Conjugal transfer protein
D0812_RS05355	COG3451	type IV secretory pathway VirB4
D0812_RS05390	COG2056	Na+-H+ antiporter family
D0812_RS05400	COG2885	chlorophyll binding
D0812_RS05410	COG0346	lactoylglutathione lyase activity
D0812_RS05470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0812_RS05470	COG0515	serine threonine protein kinase
D0812_RS05485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0812_RS05515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0812_RS05520	COG4660	Part of a membrane complex involved in electron transport
D0812_RS05525	COG4659	FMN binding
D0812_RS05530	COG4658	electron transport chain
D0812_RS05535	COG4656	Part of a membrane complex involved in electron transport
D0812_RS05545	COG4657	Part of a membrane complex involved in electron transport
D0812_RS05550	COG1882	Formate acetyltransferase
D0812_RS05565	COG0556	nucleotide-excision repair
D0812_RS05580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0812_RS05585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0812_RS05590	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0812_RS05600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D0812_RS05605	COG0314	molybdopterin synthase activity
D0812_RS05615	COG0601	transmembrane transport
D0812_RS05620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0812_RS05625	COG0444	Belongs to the ABC transporter superfamily
D0812_RS05635	COG0435	Glutathione S-transferase
D0812_RS05640	COG3174	membrane
D0812_RS05650	COG0280	phosphate acetyltransferase
D0812_RS05650	COG0857	belongs to the CobB CobQ family
D0812_RS05675	COG4120	Belongs to the binding-protein-dependent transport system permease family
D0812_RS05680	COG1122	ATPase activity
D0812_RS05685	COG0366	Alpha amylase catalytic
D0812_RS05695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0812_RS05700	COG3012	SEC-C Motif Domain Protein
D0812_RS05700	COG3318	Belongs to the UPF0149 family
D0812_RS05705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0812_RS05715	COG2186	Transcriptional regulator
D0812_RS05760	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D0812_RS05765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0812_RS05770	COG0659	secondary active sulfate transmembrane transporter activity
D0812_RS05780	COG1530	ribonuclease E activity
D0812_RS05785	COG0564	pseudouridine synthase activity
D0812_RS05790	COG0424	maF-like protein
D0812_RS05795	COG1399	metal-binding, possibly nucleic acid-binding protein
D0812_RS05810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0812_RS05840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0812_RS05855	COG0084	hydrolase, TatD family'
D0812_RS05860	COG1263	PTS System
D0812_RS05860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS05875	COG0733	neurotransmitter:sodium symporter activity
D0812_RS05890	COG4667	esterase of the alpha-beta hydrolase superfamily
D0812_RS05900	COG1940	carbohydrate kinase activity
D0812_RS05905	COG0784	Response regulator, receiver
D0812_RS05905	COG0835	chemotaxis
D0812_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS05930	COG0616	signal peptide processing
D0812_RS05940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0812_RS05945	COG0539	negative regulation of cytoplasmic translation
D0812_RS05955	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D0812_RS05960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0812_RS05970	COG4166	transmembrane transport
D0812_RS06030	COG3119	arylsulfatase activity
D0812_RS06035	COG1309	transcriptional regulator
D0812_RS06040	COG3009	Protein conserved in bacteria
D0812_RS06045	COG3008	intermembrane lipid transfer
D0812_RS06045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0812_RS06050	COG2995	paraquat-inducible protein a
D0812_RS06060	COG3258	Cytochrome c
D0812_RS06065	COG2863	cytochrome
D0812_RS06095	COG3250	beta-galactosidase activity
D0812_RS06105	COG4580	involved in the transport of maltose and maltodextrins
D0812_RS06115	COG2211	Major facilitator Superfamily
D0812_RS06120	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0812_RS06135	COG4232	protein-disulfide reductase activity
D0812_RS06140	COG3118	belongs to the thioredoxin family
D0812_RS06150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0812_RS06160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_RS06170	COG3153	acetyltransferase
D0812_RS06210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS06220	COG0577	efflux transmembrane transporter activity
D0812_RS06220	COG1136	(ABC) transporter
D0812_RS06225	COG1136	(ABC) transporter
D0812_RS06225	COG0577	efflux transmembrane transporter activity
D0812_RS06230	COG0577	efflux transmembrane transporter activity
D0812_RS06230	COG1136	(ABC) transporter
D0812_RS06240	COG2176	DNA-directed DNA polymerase activity
D0812_RS06310	COG3850	Histidine kinase
D0812_RS06310	COG5002	protein histidine kinase activity
D0812_RS06315	COG0745	RESPONSE REGULATOR receiver
D0812_RS06320	COG0463	Glycosyl transferase, family 2
D0812_RS06325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0812_RS06335	COG0840	transmembrane signaling receptor activity
D0812_RS06340	COG2964	Protein conserved in bacteria
D0812_RS06355	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0812_RS06375	COG1032	radical SAM domain protein
D0812_RS06380	COG2203	Gaf domain
D0812_RS06380	COG3706	GGDEF domain
D0812_RS06380	COG4251	negative regulation of phosphorylation
D0812_RS06380	COG5001	Diguanylate cyclase
D0812_RS06410	COG2350	Protein conserved in bacteria
D0812_RS06440	COG1301	dicarboxylic acid transport
D0812_RS06445	COG0159	tryptophan synthase activity
D0812_RS06455	COG0135	phosphoribosylanthranilate isomerase activity
D0812_RS06455	COG0134	indole-3-glycerol-phosphate synthase activity
D0812_RS06465	COG0512	Glutamine amidotransferase of anthranilate synthase
D0812_RS06470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0812_RS06480	COG0613	PHP domain protein
D0812_RS06485	COG0009	L-threonylcarbamoyladenylate synthase
D0812_RS06495	COG1187	pseudouridine synthase activity
D0812_RS06515	COG0417	DNA replication proofreading
D0812_RS06520	COG2197	response regulator
D0812_RS06525	COG0322	excinuclease ABC activity
D0812_RS06565	COG0019	diaminopimelate decarboxylase activity
D0812_RS06590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0812_RS06595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0812_RS06605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0812_RS06625	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D0812_RS06635	COG0437	4 iron, 4 sulfur cluster binding
D0812_RS06640	COG3301	Polysulphide reductase, NrfD
D0812_RS06645	COG1138	Cytochrome C-type biogenesis protein
D0812_RS06655	COG3088	subunit of a heme lyase
D0812_RS06655	COG4235	cytochrome complex assembly
D0812_RS06665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0812_RS06690	COG2989	Protein conserved in bacteria
D0812_RS06695	COG3108	Peptidase M15
D0812_RS06700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0812_RS06715	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0812_RS06740	COG1846	Transcriptional regulator
D0812_RS06745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_RS06750	COG0840	transmembrane signaling receptor activity
D0812_RS06770	COG1448	Aminotransferase
D0812_RS06775	COG3437	response regulator, receiver
D0812_RS06775	COG2770	Histidine kinase
D0812_RS06780	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_RS06790	COG1609	Transcriptional regulator
D0812_RS06805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0812_RS06820	COG0017	Asparaginyl-tRNA synthetase
D0812_RS06830	COG0720	synthase
D0812_RS06835	COG2197	response regulator
D0812_RS06845	COG5001	Diguanylate cyclase
D0812_RS06845	COG3300	MHYT domain
D0812_RS06850	COG1760	l-serine dehydratase
D0812_RS06855	COG0814	amino acid
D0812_RS06870	COG2205	protein histidine kinase activity
D0812_RS06870	COG0784	Response regulator, receiver
D0812_RS06875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0812_RS06890	COG3106	COG3106 Predicted ATPase
D0812_RS06905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_RS07115	COG2801	Transposase and inactivated derivatives
D0812_RS07325	COG1403	HNH endonuclease
D0812_RS07425	COG2801	Transposase and inactivated derivatives
D0812_RS07500	COG1733	regulation of RNA biosynthetic process
D0812_RS07510	COG3340	Belongs to the peptidase S51 family
D0812_RS07530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_RS07545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0812_RS07545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0812_RS07555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0812_RS07560	COG1609	Transcriptional regulator
D0812_RS07570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0812_RS07600	COG0456	acetyltransferase
D0812_RS07605	COG0471	metal ion transport
D0812_RS07610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_RS07610	COG4191	Histidine kinase
D0812_RS07620	COG5001	Diguanylate cyclase
D0812_RS07620	COG3300	MHYT domain
D0812_RS07630	COG1280	lysine exporter protein (LysE YggA)
D0812_RS07635	COG1328	CTP reductase activity
D0812_RS07640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0812_RS07650	COG0861	Integral membrane protein TerC family
D0812_RS07660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0812_RS07670	COG3706	GGDEF domain
D0812_RS07685	COG0814	amino acid
D0812_RS07705	COG1132	(ABC) transporter
D0812_RS07710	COG1132	(ABC) transporter
D0812_RS07715	COG2165	general secretion pathway protein
D0812_RS07725	COG0583	DNA-binding transcription factor activity
D0812_RS07750	COG0443	Heat shock 70 kDa protein
D0812_RS07755	COG0443	Heat shock 70 kDa protein
D0812_RS07765	COG3706	GGDEF domain
D0812_RS07790	COG3227	Zinc metalloprotease (Elastase)
D0812_RS07800	COG0243	molybdopterin cofactor binding
D0812_RS07805	COG0437	4 iron, 4 sulfur cluster binding
D0812_RS07810	COG3302	dmso reductase anchor subunit
D0812_RS07825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0812_RS07830	COG1643	Atp-dependent helicase
D0812_RS07855	COG3063	Type IV pilus biogenesis stability protein PilW
D0812_RS07890	COG0531	amino acid
D0812_RS07895	COG1280	lysine exporter protein (LysE YggA)
D0812_RS07900	COG0583	DNA-binding transcription factor activity
D0812_RS07905	COG0702	epimerase
D0812_RS07910	COG0583	DNA-binding transcription factor activity
D0812_RS07915	COG1560	Kdo2-lipid A biosynthetic process
D0812_RS07930	COG1846	Transcriptional regulator
D0812_RS07945	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D0812_RS07950	COG1280	lysine exporter protein (LysE YggA)
D0812_RS07980	COG1115	amino acid carrier protein
D0812_RS08035	COG0583	DNA-binding transcription factor activity
D0812_RS08040	COG1368	sulfuric ester hydrolase activity
D0812_RS08045	COG0215	cysteine-tRNA ligase activity
D0812_RS08050	COG0534	Mate efflux family protein
D0812_RS08055	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D0812_RS08065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_RS08070	COG0456	acetyltransferase
D0812_RS08075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0812_RS08080	COG0662	Cupin 2, conserved barrel domain protein
D0812_RS08085	COG0527	aspartate kinase activity
D0812_RS08100	COG0583	DNA-binding transcription factor activity
D0812_RS08105	COG1858	cytochrome C peroxidase
D0812_RS08110	COG1404	Belongs to the peptidase S8 family
D0812_RS08115	COG0583	DNA-binding transcription factor activity
D0812_RS08135	COG2169	Transcriptional regulator
D0812_RS08140	COG0697	spore germination
D0812_RS08145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0812_RS08150	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D0812_RS08160	COG0583	DNA-binding transcription factor activity
D0812_RS08165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0812_RS08185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS08200	COG3423	Transcriptional regulator
D0812_RS08210	COG2842	Transposition protein
D0812_RS08265	COG3012	SEC-C Motif Domain Protein
D0812_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS08515	COG2986	histidine ammonia-lyase
D0812_RS08520	COG1216	Glycosyl transferase, family 2
D0812_RS08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0812_RS08545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0812_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS08600	COG1169	isochorismate synthase
D0812_RS08605	COG1021	2,3-dihydroxybenzoate-AMP ligase
D0812_RS08610	COG3433	isochorismatase activity
D0812_RS08610	COG1535	isochorismatase
D0812_RS08615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0812_RS08615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0812_RS08630	COG4771	TonB-dependent receptor
D0812_RS08635	COG1253	flavin adenine dinucleotide binding
D0812_RS08640	COG0513	Belongs to the DEAD box helicase family
D0812_RS08645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_RS08650	COG0569	domain protein
D0812_RS08655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0812_RS08675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0812_RS08680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0812_RS08685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0812_RS08720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0812_RS08725	COG0776	regulation of translation
D0812_RS08730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0812_RS08735	COG1555	photosystem II stabilization
D0812_RS08755	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D0812_RS08760	COG0436	Aminotransferase
D0812_RS08765	COG1169	isochorismate synthase
D0812_RS08775	COG0596	Alpha beta hydrolase
D0812_RS08780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D0812_RS08795	COG2190	(PTS) system
D0812_RS08795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS08795	COG1263	PTS System
D0812_RS08800	COG0583	DNA-binding transcription factor activity
D0812_RS08810	COG2855	membrane
D0812_RS08865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_RS08885	COG1522	sequence-specific DNA binding
D0812_RS08895	COG1946	Acyl-CoA thioesterase
D0812_RS08900	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D0812_RS08915	COG2199	diguanylate cyclase activity
D0812_RS08945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D0812_RS08965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0812_RS08970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0812_RS08975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0812_RS08980	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D0812_RS08985	COG0516	GMP reductase activity
D0812_RS08985	COG0517	IMP dehydrogenase activity
D0812_RS09010	COG0840	transmembrane signaling receptor activity
D0812_RS09015	COG0537	adenosine 5'-monophosphoramidase activity
D0812_RS09045	COG1252	NADH dehydrogenase
D0812_RS09060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0812_RS09070	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0812_RS09075	COG1136	(ABC) transporter
D0812_RS09080	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0812_RS09095	COG1132	(ABC) transporter
D0812_RS09115	COG2719	SpoVR family
D0812_RS09120	COG2718	Belongs to the UPF0229 family
D0812_RS09125	COG2766	serine protein kinase
D0812_RS09145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0812_RS09155	COG1882	Formate acetyltransferase
D0812_RS09195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS09205	COG0708	Exodeoxyribonuclease III
D0812_RS09210	COG0840	transmembrane signaling receptor activity
D0812_RS09220	COG3923	Primosomal replication protein n
D0812_RS09225	COG0730	response to heat
D0812_RS09230	COG1199	ATP-dependent helicase activity
D0812_RS09240	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0812_RS09245	COG1187	pseudouridine synthase activity
D0812_RS09255	COG1278	Cold shock
D0812_RS09265	COG0542	response to heat
D0812_RS09270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0812_RS09300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0812_RS09305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0812_RS09310	COG0297	glycogen (starch) synthase activity
D0812_RS09330	COG3070	regulator of competence-specific genes
D0812_RS09345	COG0745	RESPONSE REGULATOR receiver
D0812_RS09350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0812_RS09355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0812_RS09365	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D0812_RS09370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D0812_RS09385	COG0318	PFAM AMP-dependent synthetase and ligase
D0812_RS09410	COG4067	protein conserved in archaea
D0812_RS09410	COG0189	ligase activity
D0812_RS09430	COG1801	Protein of unknown function DUF72
D0812_RS09445	COG0840	transmembrane signaling receptor activity
D0812_RS09450	COG0632	four-way junction helicase activity
D0812_RS09460	COG1271	oxidase subunit
D0812_RS09465	COG1294	oxidase, subunit
D0812_RS09470	COG4890	Cyd operon protein YbgT
D0812_RS09480	COG0824	Thioesterase
D0812_RS09485	COG0811	peptide transport
D0812_RS09500	COG0823	Involved in the tonB-independent uptake of proteins
D0812_RS09505	COG2885	chlorophyll binding
D0812_RS09510	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D0812_RS09525	COG3766	membrane
D0812_RS09535	COG0754	glutathionylspermidine amidase activity
D0812_RS09545	COG5002	protein histidine kinase activity
D0812_RS09545	COG0784	Response regulator, receiver
D0812_RS09575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D0812_RS09620	COG0602	queuosine metabolic process
D0812_RS09625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D0812_RS09630	COG0302	gtp cyclohydrolase
D0812_RS09635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0812_RS09640	COG0514	ATP-dependent DNA helicase (RecQ)
D0812_RS09680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0812_RS09700	COG3119	arylsulfatase activity
D0812_RS09715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS09715	COG1263	PTS System
D0812_RS09720	COG2723	6-phospho-beta-galactosidase activity
D0812_RS09725	COG2824	Alkylphosphonate utilization operon protein PhnA
D0812_RS09730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0812_RS09755	COG0534	Mate efflux family protein
D0812_RS09760	COG0444	Belongs to the ABC transporter superfamily
D0812_RS09765	COG4608	Belongs to the ABC transporter superfamily
D0812_RS09770	COG0747	negative chemotaxis
D0812_RS09800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS09805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_RS09815	COG2186	Transcriptional regulator
D0812_RS09830	COG1288	antiporter activity
D0812_RS09850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_RS09855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_RS09860	COG1120	ATPase activity
D0812_RS09880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_RS09895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D0812_RS09905	COG2176	DNA-directed DNA polymerase activity
D0812_RS09910	COG0517	IMP dehydrogenase activity
D0812_RS09915	COG2186	Transcriptional regulator
D0812_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS09925	COG2186	Transcriptional regulator
D0812_RS09950	COG1904	glucuronate isomerase
D0812_RS09955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_RS09970	COG1917	Cupin 2, conserved barrel domain protein
D0812_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS09995	COG0701	Predicted permease
D0812_RS10020	COG3568	Endonuclease Exonuclease Phosphatase
D0812_RS10030	COG4934	collagen metabolic process
D0812_RS10045	COG3181	Tripartite tricarboxylate transporter family receptor
D0812_RS10055	COG0402	S-adenosylhomocysteine deaminase activity
D0812_RS10085	COG1917	Cupin 2, conserved barrel domain protein
D0812_RS10090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS10095	COG0800	Aldolase
D0812_RS10120	COG0583	DNA-binding transcription factor activity
D0812_RS10130	COG0686	Belongs to the AlaDH PNT family
D0812_RS10140	COG1674	ftsk spoiiie
D0812_RS10150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0812_RS10165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0812_RS10170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0812_RS10210	COG0300	oxidoreductase activity
D0812_RS10225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0812_RS10235	COG2268	Band 7 protein
D0812_RS10245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0812_RS10265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS10275	COG1757	Na H antiporter
D0812_RS10285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0812_RS10295	COG0131	Imidazoleglycerol-phosphate dehydratase
D0812_RS10295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0812_RS10300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0812_RS10305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0812_RS10315	COG0140	phosphoribosyl-ATP diphosphatase activity
D0812_RS10315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0812_RS10320	COG3012	SEC-C Motif Domain Protein
D0812_RS10325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0812_RS10330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0812_RS10335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0812_RS10340	COG0215	cysteine-tRNA ligase activity
D0812_RS10345	COG1435	thymidine kinase activity
D0812_RS10350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0812_RS10375	COG2116	formate transmembrane transporter activity
D0812_RS10380	COG0390	transport system, permease component
D0812_RS10385	COG4459	periplasmic nitrate reductase
D0812_RS10390	COG3005	denitrification pathway
D0812_RS10395	COG0243	molybdopterin cofactor binding
D0812_RS10410	COG1227	inorganic diphosphatase activity
D0812_RS10420	COG4172	Belongs to the ABC transporter superfamily
D0812_RS10430	COG4171	peptide transport system, permease
D0812_RS10435	COG4168	peptide transport system, permease
D0812_RS10445	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0812_RS10450	COG1842	Phage shock protein A
D0812_RS10460	COG1983	PspC domain protein
D0812_RS10480	COG2818	Glycosylase
D0812_RS10485	COG5380	lipid catabolic process
D0812_RS10490	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D0812_RS10495	COG0626	cystathionine gamma-synthase activity
D0812_RS10505	COG0733	neurotransmitter:sodium symporter activity
D0812_RS10515	COG0564	pseudouridine synthase activity
D0812_RS10530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0812_RS10535	COG1151	hydroxylamine reductase activity
D0812_RS10540	COG3604	Transcriptional regulator
D0812_RS10545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0812_RS10550	COG4136	ATPase activity
D0812_RS10555	COG4135	transport system, permease component
D0812_RS10560	COG4134	Bacterial extracellular solute-binding protein
D0812_RS10565	COG0398	Pfam SNARE associated Golgi protein
D0812_RS10575	COG0493	'glutamate synthase
D0812_RS10600	COG0659	secondary active sulfate transmembrane transporter activity
D0812_RS10610	COG3313	Fe-S protein
D0812_RS10675	COG2199	diguanylate cyclase activity
D0812_RS10680	COG1061	Type III restriction enzyme res subunit
D0812_RS10685	COG1187	pseudouridine synthase activity
D0812_RS10690	COG2814	Major facilitator Superfamily
D0812_RS10700	COG4667	esterase of the alpha-beta hydrolase superfamily
D0812_RS10705	COG0702	epimerase
D0812_RS10710	COG0534	Mate efflux family protein
D0812_RS10715	COG4181	ATPase activity
D0812_RS10745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0812_RS10755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0812_RS10765	COG1737	Transcriptional regulator
D0812_RS10770	COG0076	glutamate decarboxylase activity
D0812_RS10780	COG2431	L-lysine efflux transmembrane transporter activity
D0812_RS10795	COG3070	regulator of competence-specific genes
D0812_RS10810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_RS10810	COG4191	Histidine kinase
D0812_RS10820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0812_RS10860	COG2200	EAL domain
D0812_RS10865	COG0583	DNA-binding transcription factor activity
D0812_RS10875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0812_RS10880	COG4988	ABC transporter
D0812_RS10885	COG0492	ferredoxin-NADP+ reductase activity
D0812_RS10905	COG3706	GGDEF domain
D0812_RS10910	COG0471	metal ion transport
D0812_RS10915	COG2949	membrane
D0812_RS10925	COG1643	Atp-dependent helicase
D0812_RS10930	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D0812_RS10990	COG0277	FAD linked oxidase domain protein
D0812_RS10990	COG0247	lactate metabolic process
D0812_RS11005	COG2986	histidine ammonia-lyase
D0812_RS11015	COG0010	Belongs to the arginase family
D0812_RS11025	COG2188	Transcriptional regulator
D0812_RS11050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0812_RS11070	COG0251	oxidation-reduction process
D0812_RS11110	COG2199	diguanylate cyclase activity
D0812_RS11120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0812_RS11120	COG0072	phenylalanine-tRNA ligase activity
D0812_RS11130	COG1621	beta-fructofuranosidase activity
D0812_RS11135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS11180	COG1346	cytolysis
D0812_RS11190	COG2925	Exonuclease
D0812_RS11200	COG1823	symporter activity
D0812_RS11205	COG0702	epimerase
D0812_RS11210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0812_RS11220	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D0812_RS11245	COG4139	cobalamin transport
D0812_RS11275	COG0583	DNA-binding transcription factor activity
D0812_RS11300	COG2165	general secretion pathway protein
D0812_RS11305	COG1451	nucleotide metabolic process
D0812_RS11325	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0812_RS11340	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D0812_RS11350	COG0625	glutathione transferase activity
D0812_RS11360	COG0657	acetylesterase activity
D0812_RS11390	COG4565	transcriptional regulatory protein
D0812_RS11400	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D0812_RS11405	COG5016	pyruvate
D0812_RS11405	COG0511	ligase activity, forming carbon-carbon bonds
D0812_RS11410	COG3630	sodium ion export across plasma membrane
D0812_RS11420	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D0812_RS11430	COG2301	Belongs to the HpcH HpaI aldolase family
D0812_RS11445	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D0812_RS11460	COG2197	response regulator
D0812_RS11475	COG1349	DNA-binding transcription factor activity
D0812_RS11480	COG0738	Major facilitator superfamily
D0812_RS11485	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
D0812_RS11490	COG1070	Carbohydrate kinase
D0812_RS11495	COG4154	Belongs to the RbsD FucU family
D0812_RS11500	COG0235	Class ii aldolase
D0812_RS11505	COG1454	alcohol dehydrogenase
D0812_RS11520	COG0589	response to stress
D0812_RS11525	COG0519	Catalyzes the synthesis of GMP from XMP
D0812_RS11590	COG0745	RESPONSE REGULATOR receiver
D0812_RS11605	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D0812_RS11620	COG0668	transmembrane transport
D0812_RS11625	COG3247	response to pH
D0812_RS11630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0812_RS11645	COG1846	Transcriptional regulator
D0812_RS11685	COG0784	Response regulator, receiver
D0812_RS11685	COG2205	protein histidine kinase activity
D0812_RS11690	COG0110	maltose O-acetyltransferase activity
D0812_RS11710	COG3850	Histidine kinase
D0812_RS11710	COG4999	Histidine kinase
D0812_RS11710	COG3437	response regulator, receiver
D0812_RS11710	COG2205	protein histidine kinase activity
D0812_RS11715	COG5001	Diguanylate cyclase
D0812_RS11715	COG3300	MHYT domain
D0812_RS11740	COG3064	Membrane
D0812_RS11750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0812_RS11755	COG1215	transferase activity, transferring glycosyl groups
D0812_RS11760	COG0297	glycogen (starch) synthase activity
D0812_RS11800	COG0438	transferase activity, transferring glycosyl groups
D0812_RS11810	COG2204	response regulator
D0812_RS11830	COG2885	chlorophyll binding
D0812_RS11840	COG1793	dna ligase
D0812_RS11850	COG0534	Mate efflux family protein
D0812_RS11855	COG0307	riboflavin synthase, alpha
D0812_RS11865	COG3001	Fructosamine kinase
D0812_RS11870	COG2201	protein-glutamate methylesterase activity
D0812_RS11875	COG3706	GGDEF domain
D0812_RS11885	COG0791	NLP P60 protein
D0812_RS11890	COG0840	transmembrane signaling receptor activity
D0812_RS11940	COG3148	PFAM DTW domain containing protein
D0812_RS11945	COG1940	carbohydrate kinase activity
D0812_RS11960	COG0303	'Molybdopterin
D0812_RS11970	COG3842	ATPase activity
D0812_RS11975	COG4662	Binding-protein-dependent transport system inner membrane component
D0812_RS11985	COG2204	response regulator
D0812_RS11990	COG4191	Histidine kinase
D0812_RS12010	COG0488	(ABC) transporter
D0812_RS12015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0812_RS12035	COG3381	protein complex oligomerization
D0812_RS12045	COG0243	molybdopterin cofactor binding
D0812_RS12045	COG3383	formate dehydrogenase (NAD+) activity
D0812_RS12050	COG0437	4 iron, 4 sulfur cluster binding
D0812_RS12065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0812_RS12070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0812_RS12080	COG1177	transmembrane transport
D0812_RS12090	COG3842	ATPase activity
D0812_RS12115	COG0589	response to stress
D0812_RS12120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0812_RS12135	COG2217	Heavy metal translocating P-type atpase
D0812_RS12145	COG2010	Cytochrome c
D0812_RS12160	COG3278	Belongs to the heme-copper respiratory oxidase family
D0812_RS12175	COG2205	protein histidine kinase activity
D0812_RS12175	COG0784	Response regulator, receiver
D0812_RS12205	COG1067	ATP-dependent peptidase activity
D0812_RS12225	COG0488	(ABC) transporter
D0812_RS12250	COG2902	Dehydrogenase
D0812_RS12260	COG0308	aminopeptidase N
D0812_RS12270	COG0793	Belongs to the peptidase S41A family
D0812_RS12275	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D0812_RS12280	COG1956	GAF domain-containing protein
D0812_RS12285	COG1132	(ABC) transporter
D0812_RS12290	COG2995	paraquat-inducible protein a
D0812_RS12295	COG3008	intermembrane lipid transfer
D0812_RS12320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0812_RS12340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_RS12345	COG4597	amino acid ABC transporter
D0812_RS12350	COG0765	amino acid transport
D0812_RS12355	COG1126	abc transporter atp-binding protein
D0812_RS12360	COG0670	Belongs to the BI1 family
D0812_RS12370	COG2920	part of a sulfur-relay system
D0812_RS12375	COG1254	Belongs to the acylphosphatase family
D0812_RS12425	COG3706	GGDEF domain
D0812_RS12435	COG0602	queuosine metabolic process
D0812_RS12440	COG0561	phosphatase activity
D0812_RS12465	COG2828	Protein conserved in bacteria
D0812_RS12470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0812_RS12475	COG0372	Belongs to the citrate synthase family
D0812_RS12480	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0812_RS12590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0812_RS12595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0812_RS12630	COG0730	response to heat
D0812_RS12640	COG2358	TRAP transporter, solute receptor (TAXI family
D0812_RS12645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_RS12655	COG1902	pentaerythritol trinitrate reductase activity
D0812_RS12660	COG1012	belongs to the aldehyde dehydrogenase family
D0812_RS12665	COG3284	Transcriptional regulator
D0812_RS12695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0812_RS12700	COG0363	glucosamine-6-phosphate deaminase activity
D0812_RS12705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0812_RS12710	COG4565	transcriptional regulatory protein
D0812_RS12715	COG3290	protein histidine kinase activity
D0812_RS12720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0812_RS12840	COG3012	SEC-C Motif Domain Protein
D0812_RS12895	COG2842	Transposition protein
D0812_RS12905	COG3423	Transcriptional regulator
D0812_RS12925	COG2951	lytic endotransglycosylase activity
D0812_RS12940	COG2894	cell division
D0812_RS12945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D0812_RS12950	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D0812_RS12955	COG0318	PFAM AMP-dependent synthetase and ligase
D0812_RS12960	COG2267	carboxylic ester hydrolase activity
D0812_RS12965	COG3065	identical protein binding
D0812_RS12975	COG1214	PFAM Peptidase M22, glycoprotease
D0812_RS12980	COG1199	ATP-dependent helicase activity
D0812_RS12985	COG0788	formyltetrahydrofolate deformylase activity
D0812_RS12990	COG3102	Protein conserved in bacteria
D0812_RS13020	COG1918	ferrous iron import across plasma membrane
D0812_RS13025	COG4977	sequence-specific DNA binding
D0812_RS13030	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D0812_RS13035	COG1121	(ABC) transporter
D0812_RS13040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0812_RS13055	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0812_RS13060	COG0567	Dehydrogenase, E1 component
D0812_RS13070	COG1053	succinate dehydrogenase
D0812_RS13075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0812_RS13090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0812_RS13100	COG0033	Phosphoglucomutase
D0812_RS13105	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D0812_RS13110	COG0596	Alpha beta hydrolase
D0812_RS13130	COG0735	belongs to the Fur family
D0812_RS13135	COG2165	general secretion pathway protein
D0812_RS13145	COG2190	(PTS) system
D0812_RS13145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS13145	COG1263	PTS System
D0812_RS13155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0812_RS13160	COG1846	Transcriptional regulator
D0812_RS13160	COG1940	carbohydrate kinase activity
D0812_RS13165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0812_RS13165	COG4651	solute:proton antiporter activity
D0812_RS13170	COG0367	asparagine synthase
D0812_RS13175	COG0250	Participates in transcription elongation, termination and antitermination
D0812_RS13180	COG3104	oligopeptide transport
D0812_RS13185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0812_RS13200	COG3710	Transcriptional regulator
D0812_RS13220	COG0622	Phosphoesterase
D0812_RS13250	COG1090	epimerase
D0812_RS13255	COG0300	oxidoreductase activity
D0812_RS13265	COG3118	belongs to the thioredoxin family
D0812_RS13275	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D0812_RS13280	COG1215	transferase activity, transferring glycosyl groups
D0812_RS13285	COG1215	transferase activity, transferring glycosyl groups
D0812_RS13305	COG2194	sulfuric ester hydrolase activity
D0812_RS13310	COG0330	HflC and HflK could
D0812_RS13350	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D0812_RS13355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0812_RS13365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS13370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0812_RS13375	COG2190	(PTS) system
D0812_RS13380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_RS13385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_RS13390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_RS13405	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0812_RS13405	COG3951	Flagellar rod assembly protein muramidase FlgJ
D0812_RS13410	COG1706	bacterial-type flagellum-dependent cell motility
D0812_RS13415	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0812_RS13425	COG4787	bacterial-type flagellum-dependent cell motility
D0812_RS13430	COG1749	Flagellar hook protein flgE
D0812_RS13440	COG1558	bacterial-type flagellum-dependent cell motility
D0812_RS13445	COG1815	bacterial-type flagellum-dependent cell motility
D0812_RS13450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D0812_RS13455	COG0835	chemotaxis
D0812_RS13455	COG0784	Response regulator, receiver
D0812_RS13510	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0812_RS13525	COG2217	Heavy metal translocating P-type atpase
D0812_RS13525	COG2608	mercury ion transmembrane transporter activity
D0812_RS13560	COG2840	Smr protein MutS2
D0812_RS13565	COG1187	pseudouridine synthase activity
D0812_RS13570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0812_RS13575	COG0737	Belongs to the 5'-nucleotidase family
D0812_RS13585	COG2912	Transglutaminase-like superfamily
D0812_RS13590	COG3094	Invasion gene expression up-regulator, SirB
D0812_RS13595	COG2890	protein-(glutamine-N5) methyltransferase activity
D0812_RS13620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0812_RS13740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0812_RS13755	COG1702	phosphate starvation-inducible protein PhoH
D0812_RS13765	COG4535	Mg2 and Co2 transporter CorC
D0812_RS13770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D0812_RS13775	COG2888	peptidyl-tyrosine sulfation
D0812_RS13780	COG0495	leucyl-tRNA aminoacylation
D0812_RS13785	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D0812_RS13790	COG1466	dna polymerase III delta subunit
D0812_RS13795	COG0799	negative regulation of ribosome biogenesis
D0812_RS13805	COG0768	penicillin binding
D0812_RS13810	COG0772	Belongs to the SEDS family
D0812_RS13815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0812_RS13820	COG1686	Belongs to the peptidase S11 family
D0812_RS13840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0812_RS13845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0812_RS13860	COG0366	Alpha amylase catalytic
D0812_RS13865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS13865	COG1263	PTS System
D0812_RS13875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0812_RS13880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0812_RS13885	COG2011	ABC-type metal ion transport system permease component
D0812_RS13890	COG1464	Belongs to the NlpA lipoprotein family
D0812_RS13900	COG0737	Belongs to the 5'-nucleotidase family
D0812_RS13905	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D0812_RS13930	COG1611	Belongs to the LOG family
D0812_RS13945	COG2363	Small membrane protein
D0812_RS13955	COG0583	DNA-binding transcription factor activity
D0812_RS13970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0812_RS13980	COG0142	geranyltranstransferase activity
D0812_RS13990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0812_RS13995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D0812_RS14020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0812_RS14020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0812_RS14025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0812_RS14030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0812_RS14045	COG1073	alpha beta
D0812_RS14055	COG2252	PERMEase
D0812_RS14060	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0812_RS14095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0812_RS14095	COG0047	phosphoribosylformylglycinamidine synthase activity
D0812_RS14110	COG0590	tRNA wobble adenosine to inosine editing
D0812_RS14120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0812_RS14140	COG4969	Belongs to the N-Me-Phe pilin family
D0812_RS14165	COG1301	dicarboxylic acid transport
D0812_RS14185	COG0497	DNA recombination
D0812_RS14190	COG0456	acetyltransferase
D0812_RS14195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0812_RS14205	COG2914	Belongs to the UPF0125 (RnfH) family
D0812_RS14210	COG2867	negative regulation of translational initiation
D0812_RS14225	COG0583	DNA-binding transcription factor activity
D0812_RS14230	COG1289	transmembrane transporter activity
D0812_RS14250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0812_RS14255	COG2873	o-acetylhomoserine
D0812_RS14260	COG0668	transmembrane transport
D0812_RS14275	COG0583	DNA-binding transcription factor activity
D0812_RS14285	COG1115	amino acid carrier protein
D0812_RS14290	COG1584	GPR1 FUN34 yaaH family protein
D0812_RS14300	COG1757	Na H antiporter
D0812_RS14310	COG0516	GMP reductase activity
D0812_RS14310	COG0517	IMP dehydrogenase activity
D0812_RS14325	COG2199	diguanylate cyclase activity
D0812_RS14325	COG2203	Gaf domain
D0812_RS14340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0812_RS14345	COG2976	Protein conserved in bacteria
D0812_RS14380	COG2975	iron-sulfur cluster assembly
D0812_RS14385	COG0633	Ferredoxin
D0812_RS14400	COG0316	Belongs to the HesB IscA family
D0812_RS14405	COG0822	iron-sulfur transferase activity
D0812_RS14420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D0812_RS14430	COG0483	inositol monophosphate 1-phosphatase activity
D0812_RS14435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0812_RS14440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0812_RS14445	COG1862	Preprotein translocase
D0812_RS14470	COG0517	IMP dehydrogenase activity
D0812_RS14480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0812_RS14485	COG0583	DNA-binding transcription factor activity
D0812_RS14490	COG0450	alkyl hydroperoxide reductase
D0812_RS14520	COG0704	Plays a role in the regulation of phosphate uptake
D0812_RS14525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0812_RS14530	COG0581	inorganic phosphate transmembrane transporter activity
D0812_RS14535	COG0573	inorganic phosphate transmembrane transporter activity
D0812_RS14540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0812_RS14545	COG0248	Ppx GppA phosphatase
D0812_RS14555	COG5002	protein histidine kinase activity
D0812_RS14560	COG0745	RESPONSE REGULATOR receiver
D0812_RS14570	COG0826	peptidase U32
D0812_RS14575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0812_RS14635	COG0542	response to heat
D0812_RS14640	COG1496	oxidoreductase activity
D0812_RS14645	COG0564	pseudouridine synthase activity
D0812_RS14650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0812_RS14655	COG0741	lytic transglycosylase activity
D0812_RS14660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0812_RS14665	COG0077	Prephenate dehydratase
D0812_RS14665	COG1605	Chorismate mutase
D0812_RS14670	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D0812_RS14685	COG0488	(ABC) transporter
D0812_RS14695	COG0739	heme binding
D0812_RS14700	COG0287	Prephenate dehydrogenase
D0812_RS14700	COG1605	Chorismate mutase
D0812_RS14705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0812_RS14715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D0812_RS14735	COG1966	Carbon starvation protein
D0812_RS14740	COG3275	phosphorelay sensor kinase activity
D0812_RS14745	COG3279	Response regulator of the LytR AlgR family
D0812_RS14750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0812_RS14755	COG1047	Peptidyl-prolyl cis-trans
D0812_RS14770	COG0196	riboflavin kinase activity
D0812_RS14775	COG0728	peptidoglycan biosynthetic process
D0812_RS14780	COG0268	Binds directly to 16S ribosomal RNA
D0812_RS14785	COG0640	Transcriptional regulator
D0812_RS14790	COG0583	DNA-binding transcription factor activity
D0812_RS14795	COG1283	sodium-dependent phosphate transmembrane transporter activity
D0812_RS14815	COG0730	response to heat
D0812_RS14840	COG0667	Aldo Keto reductase
D0812_RS14865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0812_RS14870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0812_RS14875	COG4974	Belongs to the 'phage' integrase family
D0812_RS14880	COG0716	FMN binding
D0812_RS14895	COG0513	Belongs to the DEAD box helicase family
D0812_RS14905	COG3022	response to hydroperoxide
D0812_RS14910	COG1115	amino acid carrier protein
D0812_RS14950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0812_RS14955	COG0083	homoserine kinase activity
D0812_RS14970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0812_RS14985	COG0745	RESPONSE REGULATOR receiver
D0812_RS14995	COG0784	Response regulator, receiver
D0812_RS14995	COG5002	protein histidine kinase activity
D0812_RS14995	COG2198	Histidine kinase
D0812_RS15000	COG5001	Diguanylate cyclase
D0812_RS15000	COG3706	GGDEF domain
D0812_RS15000	COG2203	Gaf domain
D0812_RS15000	COG4251	negative regulation of phosphorylation
D0812_RS15005	COG1242	4 iron, 4 sulfur cluster binding
D0812_RS15010	COG0067	glutamate synthase
D0812_RS15010	COG0069	glutamate synthase activity
D0812_RS15010	COG0070	glutamate synthase
D0812_RS15020	COG0069	glutamate synthase activity
D0812_RS15020	COG0067	glutamate synthase
D0812_RS15020	COG0070	glutamate synthase
D0812_RS15025	COG0493	'glutamate synthase
D0812_RS15050	COG2860	membrane
D0812_RS15055	COG0583	DNA-binding transcription factor activity
D0812_RS15060	COG0730	response to heat
D0812_RS15075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0812_RS15080	COG0505	Belongs to the CarA family
D0812_RS15090	COG0494	nUDIX hydrolase
D0812_RS15110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0812_RS15115	COG0849	cell division
D0812_RS15120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0812_RS15135	COG0772	Belongs to the SEDS family
D0812_RS15150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0812_RS15155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0812_RS15160	COG0768	penicillin binding
D0812_RS15165	COG3116	cell division
D0812_RS15185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D0812_RS15200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D0812_RS15205	COG2823	Periplasmic or secreted lipoprotein
D0812_RS15210	COG2969	positive regulation of protein catabolic process
D0812_RS15215	COG0625	glutathione transferase activity
D0812_RS15220	COG2857	Cytochrome c1
D0812_RS15225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0812_RS15230	COG0723	plastoquinol--plastocyanin reductase activity
D0812_RS15250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0812_RS15260	COG3105	Protein conserved in bacteria
D0812_RS15265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0812_RS15270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0812_RS15275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0812_RS15285	COG3150	esterase
D0812_RS15295	COG3151	Protein conserved in bacteria
D0812_RS15300	COG0494	nUDIX hydrolase
D0812_RS15305	COG1538	Outer membrane efflux protein
D0812_RS15315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D0812_RS15325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0812_RS15330	COG3025	triphosphatase activity
D0812_RS15335	COG1392	Phosphate transport regulator
D0812_RS15340	COG0306	phosphate transporter
D0812_RS15345	COG4991	sh3 domain protein
D0812_RS15350	COG0405	Gamma-glutamyltransferase
D0812_RS15365	COG3409	Peptidoglycan-binding domain 1 protein
D0812_RS15365	COG3267	Type II secretory pathway component ExeA
D0812_RS15380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0812_RS15385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0812_RS15395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0812_RS15400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0812_RS15405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0812_RS15410	COG1610	YqeY-like protein
D0812_RS15415	COG0358	DNA primase activity
D0812_RS15450	COG2213	PTS system mannitol-specific
D0812_RS15450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS15460	COG3722	fumarate hydratase activity
D0812_RS15465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_RS15470	COG5002	protein histidine kinase activity
D0812_RS15490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0812_RS15495	COG1349	DNA-binding transcription factor activity
D0812_RS15505	COG0469	pyruvate kinase activity
D0812_RS15525	COG0028	Belongs to the TPP enzyme family
D0812_RS15530	COG1022	Amp-dependent synthetase and ligase
D0812_RS15535	COG0583	DNA-binding transcription factor activity
D0812_RS15565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0812_RS15570	COG0473	3-isopropylmalate dehydrogenase activity
D0812_RS15590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0812_RS15595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0812_RS15600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0812_RS15605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0812_RS15630	COG3610	response to peptide
D0812_RS15635	COG2966	Psort location CytoplasmicMembrane, score
D0812_RS15650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0812_RS15655	COG0142	geranyltranstransferase activity
D0812_RS15680	COG2358	TRAP transporter, solute receptor (TAXI family
D0812_RS15695	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D0812_RS15700	COG1178	ABC-type Fe3 transport system permease component
D0812_RS15705	COG4143	(ABC) transporter
D0812_RS15710	COG0163	prenyltransferase activity
D0812_RS15715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0812_RS15725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0812_RS15740	COG2105	PFAM AIG2 family protein
D0812_RS15750	COG0729	surface antigen
D0812_RS15755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_RS15785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0812_RS15815	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0812_RS15830	COG1136	(ABC) transporter
D0812_RS15850	COG0529	Catalyzes the synthesis of activated sulfate
D0812_RS15855	COG3273	potassium ion transport
D0812_RS15855	COG0471	metal ion transport
D0812_RS15870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0812_RS15870	COG1648	precorrin-2 dehydrogenase activity
D0812_RS15875	COG0737	Belongs to the 5'-nucleotidase family
D0812_RS15890	COG0513	Belongs to the DEAD box helicase family
D0812_RS15895	COG2153	protein acetylation
D0812_RS15910	COG0545	Peptidyl-prolyl cis-trans isomerase
D0812_RS15920	COG0203	ribosomal protein L17
D0812_RS15925	COG0202	RNA polymerase activity
D0812_RS15935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0812_RS15940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0812_RS15945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0812_RS15950	COG0201	protein transport
D0812_RS15960	COG1841	ribosomal large subunit assembly
D0812_RS15980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0812_RS15990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0812_RS16025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0812_RS16030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0812_RS16045	COG0088	Forms part of the polypeptide exit tunnel
D0812_RS16060	COG0254	rRNA binding
D0812_RS16070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0812_RS16075	COG1609	Transcriptional regulator
D0812_RS16095	COG1575	Belongs to the MenA family. Type 1 subfamily
D0812_RS16100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0812_RS16110	COG1494	fructose-1,6-bisphosphatase
D0812_RS16140	COG0149	triose-phosphate isomerase activity
D0812_RS16155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0812_RS16160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0812_RS16160	COG0517	IMP dehydrogenase activity
D0812_RS16165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D0812_RS16170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D0812_RS16175	COG1215	transferase activity, transferring glycosyl groups
D0812_RS16210	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS16285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0812_RS16295	COG1560	Kdo2-lipid A biosynthetic process
D0812_RS16310	COG1519	Transferase
D0812_RS16325	COG0367	asparagine synthase
D0812_RS16350	COG1083	cytidylyl-transferase
D0812_RS16355	COG3642	lipopolysaccharide core region biosynthetic process
D0812_RS16360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0812_RS16365	COG0859	PFAM glycosyl transferase family 9
D0812_RS16370	COG0463	Glycosyl transferase, family 2
D0812_RS16385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0812_RS16425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0812_RS16435	COG1560	Kdo2-lipid A biosynthetic process
D0812_RS16440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0812_RS16445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0812_RS16450	COG1561	YicC-like family, N-terminal region
D0812_RS16455	COG0745	RESPONSE REGULATOR receiver
D0812_RS16480	COG4608	Belongs to the ABC transporter superfamily
D0812_RS16485	COG0444	Belongs to the ABC transporter superfamily
D0812_RS16490	COG0747	negative chemotaxis
D0812_RS16495	COG4239	(ABC) transporter, permease
D0812_RS16500	COG4174	ABC transporter (Permease)
D0812_RS16525	COG0811	peptide transport
D0812_RS16530	COG0848	biopolymer transport protein
D0812_RS16545	COG0194	GDP metabolic process
D0812_RS16550	COG1758	RNA polymerase activity
D0812_RS16555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0812_RS16560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0812_RS16565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0812_RS16575	COG2233	PERMEase
D0812_RS16590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0812_RS16600	COG2183	response to ionizing radiation
D0812_RS16625	COG0494	nUDIX hydrolase
D0812_RS16630	COG1218	3'(2'),5'-bisphosphate nucleotidase
D0812_RS16640	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0812_RS16645	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0812_RS16650	COG3156	type II secretion system protein K
D0812_RS16655	COG4795	General secretion pathway protein
D0812_RS16660	COG2165	general secretion pathway protein
D0812_RS16665	COG2165	general secretion pathway protein
D0812_RS16670	COG2165	general secretion pathway protein
D0812_RS16675	COG1459	type II secretion system
D0812_RS16680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0812_RS16690	COG3031	protein transport across the cell outer membrane
D0812_RS16695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D0812_RS16715	COG0456	acetyltransferase
D0812_RS16720	COG1490	D-aminoacyl-tRNA deacylase activity
D0812_RS16740	COG1217	gtp-binding protein TYPA
D0812_RS16750	COG0174	glutamine synthetase
D0812_RS16760	COG3852	Histidine kinase
D0812_RS16765	COG2204	response regulator
D0812_RS16775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0812_RS16810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D0812_RS16820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0812_RS16820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0812_RS16840	COG0084	hydrolase, TatD family'
D0812_RS16845	COG0805	protein transport
D0812_RS16850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0812_RS16865	COG3165	ubiquinone biosynthetic process from chorismate
D0812_RS16875	COG1322	Protein conserved in bacteria
D0812_RS16910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D0812_RS16985	COG2081	HI0933 family
D0812_RS17020	COG1528	Iron-storage protein
D0812_RS17025	COG0589	response to stress
D0812_RS17045	COG5002	protein histidine kinase activity
D0812_RS17045	COG5001	Diguanylate cyclase
D0812_RS17050	COG1522	sequence-specific DNA binding
D0812_RS17065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0812_RS17075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0812_RS17120	COG3501	Rhs element vgr protein
D0812_RS17150	COG0800	Aldolase
D0812_RS17155	COG2610	gluconate transmembrane transporter activity
D0812_RS17160	COG3265	gluconokinase activity
D0812_RS17165	COG0129	dihydroxy-acid dehydratase activity
D0812_RS17175	COG2076	Multidrug Resistance protein
D0812_RS17180	COG0583	DNA-binding transcription factor activity
D0812_RS17185	COG1609	Transcriptional regulator
D0812_RS17220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0812_RS17225	COG0601	transmembrane transport
D0812_RS17235	COG4172	Belongs to the ABC transporter superfamily
D0812_RS17245	COG0546	phosphoglycolate phosphatase activity
D0812_RS17285	COG1309	transcriptional regulator
D0812_RS17290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS17295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_RS17305	COG2960	long-chain fatty acid transporting porin activity
D0812_RS17310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0812_RS17315	COG0583	DNA-binding transcription factor activity
D0812_RS17360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0812_RS17385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0812_RS17390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0812_RS17395	COG0551	DNA topoisomerase type I activity
D0812_RS17405	COG0758	DNA mediated transformation
D0812_RS17415	COG0242	peptide deformylase activity
D0812_RS17425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0812_RS17425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0812_RS17430	COG0569	domain protein
D0812_RS17435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0812_RS17445	COG1272	protein, Hemolysin III
D0812_RS17450	COG4326	sporulation control protein
D0812_RS17460	COG3084	Protein conserved in bacteria
D0812_RS17470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0812_RS17475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0812_RS17480	COG0204	Acyl-transferase
D0812_RS17490	COG0606	chelatase, subunit chli
D0812_RS17500	COG3978	acetolactate synthase activity
D0812_RS17505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0812_RS17510	COG0129	dihydroxy-acid dehydratase activity
D0812_RS17520	COG3706	GGDEF domain
D0812_RS17525	COG0583	DNA-binding transcription factor activity
D0812_RS17530	COG2814	Major facilitator Superfamily
D0812_RS17535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_RS17540	COG0765	amino acid transport
D0812_RS17550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0812_RS17560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0812_RS17590	COG3312	ion transport
D0812_RS17595	COG1475	DNA binding
D0812_RS17600	COG1192	Involved in chromosome partitioning
D0812_RS17615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0812_RS17645	COG1126	abc transporter atp-binding protein
D0812_RS17660	COG3835	regulator
D0812_RS17665	COG1929	Belongs to the glycerate kinase type-1 family
D0812_RS17670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0812_RS17715	COG0456	acetyltransferase
D0812_RS17735	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS17745	COG3005	denitrification pathway
D0812_RS17750	COG0243	molybdopterin cofactor binding
D0812_RS17755	COG5002	protein histidine kinase activity
D0812_RS17765	COG0671	phosphoesterase, PA-phosphatase related
D0812_RS17790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D0812_RS17795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0812_RS17800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0812_RS17805	COG1116	anion transmembrane transporter activity
D0812_RS17810	COG0351	phosphomethylpyrimidine kinase
D0812_RS17815	COG0312	modulator of DNA gyrase
D0812_RS17820	COG0312	modulator of DNA gyrase
D0812_RS17885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0812_RS17895	COG0584	glycerophosphoryl diester phosphodiesterase
D0812_RS17900	COG0039	L-malate dehydrogenase activity
D0812_RS17905	COG0745	RESPONSE REGULATOR receiver
D0812_RS17925	COG0811	peptide transport
D0812_RS17930	COG0811	peptide transport
D0812_RS17935	COG0848	biopolymer transport protein
D0812_RS17980	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0812_RS17985	COG1121	(ABC) transporter
D0812_RS17990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0812_RS18005	COG1770	oligopeptidase
D0812_RS18010	COG2814	Major facilitator Superfamily
D0812_RS18015	COG0010	Belongs to the arginase family
D0812_RS18020	COG1166	arginine decarboxylase activity
D0812_RS18030	COG4067	protein conserved in archaea
D0812_RS18030	COG0189	ligase activity
D0812_RS18035	COG0189	ligase activity
D0812_RS18060	COG0583	DNA-binding transcription factor activity
D0812_RS18100	COG3706	GGDEF domain
D0812_RS18125	COG0579	oxidoreductase
D0812_RS18130	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D0812_RS18145	COG3033	Beta-eliminating lyase
D0812_RS18165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0812_RS18170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0812_RS18190	COG3706	GGDEF domain
D0812_RS18205	COG3706	GGDEF domain
D0812_RS18210	COG0415	Belongs to the DNA photolyase family
D0812_RS18215	COG3046	protein related to deoxyribodipyrimidine photolyase
D0812_RS18230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_RS18230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_RS18235	COG1765	OsmC-like protein
D0812_RS18275	COG1011	Hydrolase
D0812_RS18310	COG3240	lipase activity
D0812_RS18340	COG1609	Transcriptional regulator
D0812_RS18350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0812_RS18360	COG1840	ABC-type Fe3 transport system, periplasmic component
D0812_RS18370	COG3842	ATPase activity
D0812_RS18395	COG2990	Protein conserved in bacteria
D0812_RS18405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0812_RS18410	COG2866	Carboxypeptidase
D0812_RS18420	COG0583	DNA-binding transcription factor activity
D0812_RS18445	COG3104	oligopeptide transport
D0812_RS18450	COG1760	l-serine dehydratase
D0812_RS18475	COG1388	LysM domain
D0812_RS18475	COG0741	lytic transglycosylase activity
D0812_RS18495	COG1815	bacterial-type flagellum-dependent cell motility
D0812_RS18500	COG1558	bacterial-type flagellum-dependent cell motility
D0812_RS18505	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0812_RS18510	COG1749	Flagellar hook protein flgE
D0812_RS18515	COG4787	bacterial-type flagellum-dependent cell motility
D0812_RS18520	COG4786	Flagellar basal body rod
D0812_RS18525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0812_RS18530	COG1706	bacterial-type flagellum-dependent cell motility
D0812_RS18540	COG1256	bacterial-type flagellum assembly
D0812_RS18540	COG4786	Flagellar basal body rod
D0812_RS18545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_RS18570	COG0583	DNA-binding transcription factor activity
D0812_RS18590	COG1253	flavin adenine dinucleotide binding
D0812_RS18595	COG3710	Transcriptional regulator
D0812_RS18610	COG2226	methyltransferase
D0812_RS18665	COG1360	Flagellar Motor Protein
D0812_RS18670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0812_RS18675	COG1191	sigma factor activity
D0812_RS18680	COG1580	Controls the rotational direction of flagella during chemotaxis
D0812_RS18695	COG1516	flagellar protein fliS
D0812_RS18700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0812_RS18710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_RS18725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0812_RS18735	COG1987	bacterial-type flagellum assembly
D0812_RS18795	COG5002	protein histidine kinase activity
D0812_RS18795	COG5001	Diguanylate cyclase
D0812_RS18810	COG0697	spore germination
D0812_RS18855	COG0346	lactoylglutathione lyase activity
D0812_RS18880	COG0745	RESPONSE REGULATOR receiver
D0812_RS18905	COG0156	8-amino-7-oxononanoate synthase activity
D0812_RS18910	COG1063	alcohol dehydrogenase
D0812_RS18970	COG0668	transmembrane transport
D0812_RS18985	COG1304	FMN binding
D0812_RS18990	COG1620	l-lactate permease
D0812_RS18995	COG0583	DNA-binding transcription factor activity
D0812_RS19000	COG1505	serine-type exopeptidase activity
D0812_RS19005	COG4172	Belongs to the ABC transporter superfamily
D0812_RS19015	COG1067	ATP-dependent peptidase activity
D0812_RS19025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0812_RS19045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_RS19050	COG0437	4 iron, 4 sulfur cluster binding
D0812_RS19055	COG0348	domain, Protein
D0812_RS19070	COG0640	Transcriptional regulator
D0812_RS19080	COG2731	YhcH YjgK YiaL family protein
D0812_RS19095	COG1122	ATPase activity
D0812_RS19105	COG1566	PFAM secretion protein HlyD family protein
D0812_RS19135	COG0813	purine-nucleoside phosphorylase activity
D0812_RS19145	COG3272	Protein of unknown function (DUF1722)
D0812_RS19150	COG0789	Transcriptional regulator
D0812_RS19155	COG0415	Belongs to the DNA photolyase family
D0812_RS19160	COG1388	LysM domain
D0812_RS19160	COG1376	ErfK ybiS ycfS ynhG family protein
D0812_RS19170	COG0513	Belongs to the DEAD box helicase family
D0812_RS19230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D0812_RS19240	COG4974	Belongs to the 'phage' integrase family
D0812_RS19260	COG1770	oligopeptidase
D0812_RS19265	COG4771	TonB-dependent receptor
D0812_RS19295	COG0573	inorganic phosphate transmembrane transporter activity
D0812_RS19300	COG0581	inorganic phosphate transmembrane transporter activity
D0812_RS19305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0812_RS19320	COG2304	oxidoreductase activity
D0812_RS19340	COG0714	Associated with various cellular activities
D0812_RS19360	COG0840	transmembrane signaling receptor activity
D0812_RS19395	COG0110	maltose O-acetyltransferase activity
D0812_RS19400	COG2204	response regulator
D0812_RS19415	COG0573	inorganic phosphate transmembrane transporter activity
D0812_RS19425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0812_RS19430	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS19480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0812_RS19485	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D0812_RS19495	COG1252	NADH dehydrogenase
D0812_RS19500	COG1301	dicarboxylic acid transport
D0812_RS19510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_RS19545	COG1566	PFAM secretion protein HlyD family protein
D0812_RS19550	COG0583	DNA-binding transcription factor activity
D0812_RS19565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS19565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS19565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS19570	COG2207	Transcriptional regulator
D0812_RS19580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS19585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS19590	COG0583	DNA-binding transcription factor activity
D0812_RS19600	COG2084	Dehydrogenase
D0812_RS19605	COG0753	catalase activity
D0812_RS19615	COG2130	NADP-dependent
D0812_RS19620	COG1309	transcriptional regulator
D0812_RS19660	COG0438	transferase activity, transferring glycosyl groups
D0812_RS19685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0812_RS19690	COG3842	ATPase activity
D0812_RS19705	COG1175	transmembrane transport
D0812_RS19710	COG3833	ABC-type maltose transport systems, permease component
D0812_RS19740	COG2354	Protein conserved in bacteria
D0812_RS19750	COG0401	homolog of Blt101
D0812_RS19755	COG3217	Mosc domain protein beta barrel domain protein
D0812_RS19755	COG0633	Ferredoxin
D0812_RS19755	COG3217	Mosc domain protein beta barrel domain protein
D0812_RS19755	COG0633	Ferredoxin
D0812_RS19765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0812_RS19805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D0812_RS19810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_RS19820	COG0848	biopolymer transport protein
D0812_RS19825	COG0811	peptide transport
D0812_RS19830	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D0812_RS19840	COG3721	Heme iron utilization protein
D0812_RS19845	COG0748	coenzyme F420 binding
D0812_RS19860	COG0835	chemotaxis
D0812_RS19860	COG0784	Response regulator, receiver
D0812_RS19865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0812_RS19870	COG0366	Alpha amylase catalytic
D0812_RS19875	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS19875	COG3321	synthase
D0812_RS19875	COG0604	alcohol dehydrogenase
D0812_RS19930	COG0583	DNA-binding transcription factor activity
D0812_RS19950	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0812_RS19955	COG0583	DNA-binding transcription factor activity
D0812_RS19975	COG2814	Major facilitator Superfamily
D0812_RS19990	COG1335	isochorismatase
D0812_RS20005	COG2194	sulfuric ester hydrolase activity
D0812_RS20010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0812_RS20020	COG2205	protein histidine kinase activity
D0812_RS20025	COG0745	RESPONSE REGULATOR receiver
D0812_RS20030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_RS20035	COG4948	Mandelate Racemase Muconate Lactonizing
D0812_RS20040	COG1053	succinate dehydrogenase
D0812_RS20040	COG3976	FMN-binding domain protein
D0812_RS20050	COG4221	oxidoreductase activity
D0812_RS20065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0812_RS20085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0812_RS20095	COG2814	Major facilitator Superfamily
D0812_RS20110	COG1418	mRNA catabolic process
D0812_RS20125	COG0402	S-adenosylhomocysteine deaminase activity
D0812_RS20130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0812_RS20135	COG2239	Acts as a magnesium transporter
D0812_RS20140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0812_RS20145	COG1566	PFAM secretion protein HlyD family protein
D0812_RS20170	COG0745	RESPONSE REGULATOR receiver
D0812_RS20175	COG2205	protein histidine kinase activity
D0812_RS20195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS20205	COG0531	amino acid
D0812_RS20210	COG1522	sequence-specific DNA binding
D0812_RS20245	COG0673	inositol 2-dehydrogenase activity
D0812_RS20325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0812_RS20330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0812_RS20340	COG1280	lysine exporter protein (LysE YggA)
D0812_RS20350	COG0183	Belongs to the thiolase family
D0812_RS20370	COG3005	denitrification pathway
D0812_RS20390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0812_RS20395	COG3850	Histidine kinase
D0812_RS20400	COG2197	response regulator
D0812_RS20415	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0812_RS20435	COG0840	transmembrane signaling receptor activity
D0812_RS20445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_RS20475	COG0545	Peptidyl-prolyl cis-trans isomerase
D0812_RS20505	COG1278	Cold shock
D0812_RS20510	COG3036	rescue of stalled ribosome
D0812_RS20540	COG0577	efflux transmembrane transporter activity
D0812_RS20540	COG1136	(ABC) transporter
D0812_RS20570	COG1538	Outer membrane efflux protein
D0812_RS20575	COG2205	protein histidine kinase activity
D0812_RS20575	COG0784	Response regulator, receiver
D0812_RS20605	COG0783	Belongs to the Dps family
D0812_RS20615	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0812_RS20620	COG2133	pyrroloquinoline quinone binding
D0812_RS20625	COG1454	alcohol dehydrogenase
D0812_RS20630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D0812_RS20650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0812_RS20655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0812_RS20665	COG3186	Phenylalanine-4-hydroxylase
D0812_RS20700	COG3530	Putative quorum-sensing-regulated virulence factor
D0812_RS20730	COG0523	cobalamin synthesis protein
D0812_RS20740	COG0513	Belongs to the DEAD box helicase family
D0812_RS20760	COG2200	EAL domain
D0812_RS20765	COG1119	ATPase activity
D0812_RS20825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0812_RS20840	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D0812_RS20845	COG0513	Belongs to the DEAD box helicase family
D0812_RS20855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0812_RS20870	COG3278	Belongs to the heme-copper respiratory oxidase family
D0812_RS20895	COG1024	Enoyl-CoA hydratase
D0812_RS20900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0812_RS20905	COG1960	acyl-CoA dehydrogenase activity
D0812_RS20915	COG0183	Belongs to the thiolase family
D0812_RS20930	COG1024	Enoyl-CoA hydratase
D0812_RS20935	COG1024	Enoyl-CoA hydratase
D0812_RS20945	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS20955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0812_RS20960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0812_RS20965	COG1845	cytochrome c oxidase, subunit III
D0812_RS20970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0812_RS20980	COG1902	pentaerythritol trinitrate reductase activity
D0812_RS20980	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0812_RS20995	COG1012	belongs to the aldehyde dehydrogenase family
D0812_RS21005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_RS21070	COG1126	abc transporter atp-binding protein
D0812_RS21075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_RS21080	COG4215	(ABC) transporter
D0812_RS21085	COG4160	amino acid transport
D0812_RS21090	COG0840	transmembrane signaling receptor activity
D0812_RS21110	COG3119	arylsulfatase activity
D0812_RS21115	COG1053	succinate dehydrogenase
D0812_RS21115	COG0431	NADPH-dependent FMN reductase
D0812_RS21115	COG3976	FMN-binding domain protein
D0812_RS21165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0812_RS21180	COG0443	Heat shock 70 kDa protein
D0812_RS21185	COG2847	Copper chaperone PCu(A)C
D0812_RS21215	COG0745	RESPONSE REGULATOR receiver
D0812_RS21230	COG1785	Belongs to the alkaline phosphatase family
D0812_RS21265	COG0814	amino acid
D0812_RS21270	COG5001	Diguanylate cyclase
D0812_RS21270	COG5002	protein histidine kinase activity
D0812_RS21280	COG0243	molybdopterin cofactor binding
D0812_RS21310	COG1116	anion transmembrane transporter activity
D0812_RS21310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0812_RS21315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0812_RS21320	COG1116	anion transmembrane transporter activity
D0812_RS21325	COG2146	nitrite reductase [NAD(P)H] activity
D0812_RS21325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0812_RS21360	COG2165	general secretion pathway protein
D0812_RS21370	COG2165	general secretion pathway protein
D0812_RS21375	COG0745	RESPONSE REGULATOR receiver
D0812_RS21380	COG2770	Histidine kinase
D0812_RS21380	COG2205	protein histidine kinase activity
D0812_RS21385	COG2165	general secretion pathway protein
D0812_RS21405	COG1902	pentaerythritol trinitrate reductase activity
D0812_RS21415	COG1475	DNA binding
D0812_RS21435	COG0814	amino acid
D0812_RS21450	COG1414	Transcriptional regulator
D0812_RS21460	COG0589	response to stress
D0812_RS21470	COG2111	Na H antiporter
D0812_RS21470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0812_RS21475	COG1006	Multisubunit Na H antiporter MnhC subunit
D0812_RS21480	COG0651	ATP synthesis coupled electron transport
D0812_RS21485	COG1863	multisubunit Na H antiporter MnhE subunit
D0812_RS21490	COG2212	antiporter activity
D0812_RS21495	COG1320	monovalent cation:proton antiporter activity
D0812_RS21500	COG1294	oxidase, subunit
D0812_RS21505	COG1271	oxidase subunit
D0812_RS21515	COG0583	DNA-binding transcription factor activity
D0812_RS21525	COG0739	heme binding
D0812_RS21560	COG0628	permease
D0812_RS21595	COG3321	synthase
D0812_RS21595	COG0604	alcohol dehydrogenase
D0812_RS21600	COG1024	Enoyl-CoA hydratase
D0812_RS21620	COG2207	Transcriptional regulator
D0812_RS21620	COG0662	Cupin 2, conserved barrel domain protein
D0812_RS21690	COG1132	(ABC) transporter
D0812_RS21715	COG0583	DNA-binding transcription factor activity
D0812_RS21720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0812_RS21735	COG2814	Major facilitator Superfamily
D0812_RS21745	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS21760	COG1196	nuclear chromosome segregation
D0812_RS21775	COG0509	glycine decarboxylation via glycine cleavage system
D0812_RS21780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0812_RS21795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D0812_RS21805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS21810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS21840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D0812_RS21840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS21840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS21845	COG1105	Belongs to the carbohydrate kinase PfkB family
D0812_RS21850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS21850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS21855	COG1609	Transcriptional regulator
D0812_RS21870	COG2200	EAL domain
D0812_RS21870	COG2203	Gaf domain
D0812_RS21870	COG2199	diguanylate cyclase activity
D0812_RS21875	COG0765	amino acid transport
D0812_RS21880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_RS21940	COG5532	Uncharacterized conserved protein (DUF2303)
D0812_RS21965	COG1484	DNA-dependent DNA replication
D0812_RS22230	COG0765	amino acid transport
D0812_RS22235	COG1126	abc transporter atp-binding protein
D0812_RS22245	COG1979	alcohol dehydrogenase
D0812_RS22250	COG2207	Transcriptional regulator
D0812_RS22260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0812_RS22270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS22285	COG3437	response regulator, receiver
D0812_RS22285	COG0784	Response regulator, receiver
D0812_RS22290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_RS22300	COG0840	transmembrane signaling receptor activity
D0812_RS22310	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D0812_RS22315	COG0513	Belongs to the DEAD box helicase family
D0812_RS22320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0812_RS22335	COG3038	cytochrome b561
D0812_RS22345	COG2116	formate transmembrane transporter activity
D0812_RS22355	COG0583	DNA-binding transcription factor activity
D0812_RS22365	COG3593	DNA synthesis involved in DNA repair
D0812_RS22370	COG0737	Belongs to the 5'-nucleotidase family
D0812_RS22390	COG1410	methionine synthase
D0812_RS22390	COG0646	methionine synthase
D0812_RS22405	COG2267	carboxylic ester hydrolase activity
D0812_RS22425	COG2050	protein possibly involved in aromatic compounds catabolism
D0812_RS22460	COG0484	heat shock protein binding
D0812_RS22470	COG5001	Diguanylate cyclase
D0812_RS22470	COG3300	MHYT domain
D0812_RS22475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0812_RS22485	COG4181	ATPase activity
D0812_RS22490	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D0812_RS22500	COG1984	allophanate hydrolase subunit 2
D0812_RS22505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0812_RS22515	COG3447	MASE1 domain protein
D0812_RS22515	COG5001	Diguanylate cyclase
D0812_RS22515	COG5002	protein histidine kinase activity
D0812_RS22520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0812_RS22535	COG0583	DNA-binding transcription factor activity
D0812_RS22540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_RS22540	COG0045	succinate-CoA ligase (ADP-forming) activity
D0812_RS22540	COG1042	CoA-binding domain protein
D0812_RS22560	COG0023	Translation Initiation Factor
D0812_RS22580	COG3140	Belongs to the UPF0181 family
D0812_RS22605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D0812_RS22610	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D0812_RS22650	COG3706	GGDEF domain
D0812_RS22650	COG4251	negative regulation of phosphorylation
D0812_RS22650	COG5001	Diguanylate cyclase
D0812_RS22650	COG2203	Gaf domain
D0812_RS22660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D0812_RS22665	COG4149	molybdate abc transporter
D0812_RS22670	COG0725	ABC transporter, periplasmic molybdate-binding protein
D0812_RS22680	COG3111	PFAM Bacterial OB fold (BOF) protein
D0812_RS22705	COG0534	Mate efflux family protein
D0812_RS22710	COG0602	queuosine metabolic process
D0812_RS22715	COG1328	CTP reductase activity
D0812_RS22800	COG2197	response regulator
D0812_RS22805	COG3851	Histidine kinase
D0812_RS22810	COG2271	Major facilitator Superfamily
D0812_RS22815	COG1482	cell wall glycoprotein biosynthetic process
D0812_RS22825	COG0628	permease
D0812_RS22835	COG1566	PFAM secretion protein HlyD family protein
D0812_RS22865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0812_RS22870	COG3118	belongs to the thioredoxin family
D0812_RS22880	COG3292	Two component regulator propeller
D0812_RS22880	COG0745	RESPONSE REGULATOR receiver
D0812_RS22880	COG2205	protein histidine kinase activity
D0812_RS22885	COG0534	Mate efflux family protein
D0812_RS22905	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0812_RS22925	COG2116	formate transmembrane transporter activity
D0812_RS22935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0812_RS22945	COG2199	diguanylate cyclase activity
D0812_RS23020	COG0277	FAD linked oxidase domain protein
D0812_RS23025	COG0583	DNA-binding transcription factor activity
D0812_RS23030	COG1472	Belongs to the glycosyl hydrolase 3 family
D0812_RS23045	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D0812_RS23060	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0812_RS23070	COG1288	antiporter activity
D0812_RS23080	COG2814	Major facilitator Superfamily
D0812_RS23090	COG3040	lipid binding
D0812_RS23130	COG3469	chitinase activity
D0812_RS23140	COG0419	ATPase involved in DNA repair
D0812_RS23145	COG0420	3'-5' exonuclease activity
D0812_RS23225	COG0631	protein serine/threonine phosphatase activity
D0812_RS23260	COG0515	serine threonine protein kinase
D0812_RS23260	COG2815	serine threonine protein kinase
D0812_RS23300	COG0346	lactoylglutathione lyase activity
D0812_RS23305	COG1902	pentaerythritol trinitrate reductase activity
D0812_RS23315	COG2755	lipolytic protein G-D-S-L family
D0812_RS23315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0812_RS23325	COG5642	Protein of unknown function (DUF2384)
D0812_RS23340	COG1234	tRNA 3'-trailer cleavage
D0812_RS23345	COG2067	long-chain fatty acid transport protein
D0812_RS23395	COG0671	phosphoesterase, PA-phosphatase related
D0812_RS23410	COG2962	Rard protein
D0812_RS23420	COG2165	general secretion pathway protein
D0812_RS23425	COG0835	chemotaxis
D0812_RS23425	COG0784	Response regulator, receiver
D0812_RS23430	COG0778	Nitroreductase
D0812_RS23440	COG2197	response regulator
D0812_RS23450	COG3706	GGDEF domain
D0812_RS23455	COG2197	response regulator
D0812_RS23460	COG5001	Diguanylate cyclase
D0812_RS23460	COG3300	MHYT domain
D0812_RS23465	COG0784	Response regulator, receiver
D0812_RS23465	COG2205	protein histidine kinase activity
D0812_RS23480	COG4771	TonB-dependent receptor
D0812_RS23535	COG1522	sequence-specific DNA binding
D0812_RS23570	COG0515	serine threonine protein kinase
D0812_RS23595	COG3501	Rhs element vgr protein
D0812_RS23610	COG2204	response regulator
D0812_RS23615	COG2885	chlorophyll binding
D0812_RS23635	COG0739	heme binding
D0812_RS23640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0812_RS23670	COG3069	C4-dicarboxylate transmembrane transporter activity
D0812_RS23675	COG1704	LemA family
D0812_RS23680	COG0501	Belongs to the peptidase M48B family
D0812_RS23710	COG0641	radical SAM
D0812_RS23730	COG3111	PFAM Bacterial OB fold (BOF) protein
D0812_RS23735	COG1597	lipid kinase activity
D0812_RS23750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0812_RS23760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0812_RS23820	COG0714	Associated with various cellular activities
D0812_RS23830	COG3119	arylsulfatase activity
D0812_RS23835	COG0583	DNA-binding transcription factor activity
D0812_RS23845	COG3119	arylsulfatase activity
D0812_RS23850	COG3119	arylsulfatase activity
D0812_RS23855	COG3119	arylsulfatase activity
D0812_RS23885	COG2198	Histidine kinase
D0812_RS23885	COG0784	Response regulator, receiver
D0812_RS23885	COG2205	protein histidine kinase activity
D0812_RS23890	COG1879	ABC-type sugar transport system periplasmic component
D0812_RS23900	COG0210	DNA helicase
D0812_RS23905	COG1289	transmembrane transporter activity
D0812_RS23940	COG4206	TonB-dependent receptor
D0812_RS23950	COG0789	Transcriptional regulator
D0812_RS23955	COG4604	ABC transporter, ATP-binding protein
D0812_RS23960	COG4605	iron ion homeostasis
D0812_RS23965	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_RS23970	COG4607	ABC-type enterochelin transport system periplasmic component
D0812_RS23985	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D0812_RS24000	COG1609	Transcriptional regulator
D0812_RS24005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS24015	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0812_RS24020	COG1129	ABC transporter
D0812_RS24030	COG5001	Diguanylate cyclase
D0812_RS24035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0812_RS24040	COG1794	racemase activity, acting on amino acids and derivatives
D0812_RS24045	COG1051	belongs to the nudix hydrolase family
D0812_RS24070	COG0586	Pfam SNARE associated Golgi protein
D0812_RS24090	COG0745	RESPONSE REGULATOR receiver
D0812_RS24135	COG0583	DNA-binding transcription factor activity
D0812_RS24145	COG2205	protein histidine kinase activity
D0812_RS24145	COG0784	Response regulator, receiver
D0812_RS24155	COG2205	protein histidine kinase activity
D0812_RS24155	COG0784	Response regulator, receiver
D0812_RS24160	COG2203	Gaf domain
D0812_RS24160	COG2200	EAL domain
D0812_RS24160	COG2199	diguanylate cyclase activity
D0812_RS24190	COG0330	HflC and HflK could
D0812_RS24255	COG0529	Catalyzes the synthesis of activated sulfate
D0812_RS24260	COG0471	metal ion transport
D0812_RS24260	COG3273	potassium ion transport
D0812_RS24270	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D0812_RS24285	COG0438	transferase activity, transferring glycosyl groups
D0812_RS24305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D0812_RS24310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D0812_RS24315	COG2895	sulfate adenylyltransferase (ATP) activity
D0812_RS24320	COG0175	sulfate reduction
D0812_RS24330	COG1596	polysaccharide export
D0812_RS24335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0812_RS24340	COG0517	IMP dehydrogenase activity
D0812_RS24340	COG4175	Glycine betaine
D0812_RS24345	COG4176	ABC-type proline glycine betaine transport system permease component
D0812_RS24380	COG3706	GGDEF domain
D0812_RS24390	COG0402	S-adenosylhomocysteine deaminase activity
D0812_RS24425	COG4580	involved in the transport of maltose and maltodextrins
D0812_RS24430	COG1874	Beta-galactosidase
D0812_RS24440	COG3833	ABC-type maltose transport systems, permease component
D0812_RS24445	COG1175	transmembrane transport
D0812_RS24450	COG2182	Extracellular solute-binding protein
D0812_RS24465	COG1609	Transcriptional regulator
D0812_RS24475	COG1609	Transcriptional regulator
D0812_RS24480	COG2017	converts alpha-aldose to the beta-anomer
D0812_RS24495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0812_RS24520	COG0640	Transcriptional regulator
D0812_RS24550	COG0840	transmembrane signaling receptor activity
D0812_RS24570	COG0732	type I restriction modification DNA specificity domain
D0812_RS24575	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D0812_RS24620	COG1061	Type III restriction enzyme res subunit
D0812_RS24645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0812_RS24645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D0812_RS24660	COG4989	oxidoreductase activity
D0812_RS24685	COG1914	H( )-stimulated, divalent metal cation uptake system
D0812_RS24725	COG2897	thiosulfate sulfurtransferase activity
D0812_RS24755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0812_RS24760	COG0840	transmembrane signaling receptor activity
D0812_RS24765	COG2814	Major facilitator Superfamily
D0812_RS24770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0812_RS24785	COG1612	heme a metabolic process
D0812_RS24805	COG1845	cytochrome c oxidase, subunit III
D0812_RS24810	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D0812_RS24825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0812_RS24835	COG1280	lysine exporter protein (LysE YggA)
D0812_RS24855	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0812_RS24870	COG0697	spore germination
D0812_RS24890	COG2814	Major facilitator Superfamily
D0812_RS24895	COG0583	DNA-binding transcription factor activity
D0812_RS24910	COG4774	siderophore transport
D0812_RS24925	COG1120	ATPase activity
D0812_RS24930	COG5001	Diguanylate cyclase
D0812_RS24935	COG0739	heme binding
D0812_RS24960	COG3314	Sporulation integral membrane protein YlbJ
D0812_RS24975	COG0814	amino acid
D0812_RS24995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0812_RS25000	COG1072	(Pantothenic acid kinase))
D0812_RS25010	COG1063	alcohol dehydrogenase
D0812_RS25015	COG2213	PTS system mannitol-specific
D0812_RS25020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS25025	COG2188	Transcriptional regulator
D0812_RS25030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_RS25030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS25030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS25035	COG0383	alpha-mannosidase activity
D0812_RS25040	COG1482	cell wall glycoprotein biosynthetic process
D0812_RS25050	COG4989	oxidoreductase activity
D0812_RS25070	COG1733	regulation of RNA biosynthetic process
D0812_RS25085	COG0798	PFAM Bile acid sodium symporter
D0812_RS25100	COG1881	PFAM PEBP family protein
D0812_RS25110	COG0251	oxidation-reduction process
D0812_RS25115	COG2706	6-phosphogluconolactonase activity
D0812_RS25130	COG0800	Aldolase
D0812_RS25135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS25140	COG4145	pantothenate transmembrane transporter activity
D0812_RS25150	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D0812_RS25175	COG1131	(ABC) transporter
D0812_RS25180	COG0842	Transport permease protein
D0812_RS25195	COG3383	formate dehydrogenase (NAD+) activity
D0812_RS25215	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_RS25240	COG3321	synthase
D0812_RS25240	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS25240	COG0604	alcohol dehydrogenase
D0812_RS25260	COG0494	nUDIX hydrolase
D0812_RS25275	COG1858	cytochrome C peroxidase
D0812_RS25285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_RS25295	COG2067	long-chain fatty acid transport protein
D0812_RS25305	COG1505	serine-type exopeptidase activity
D0812_RS25310	COG0488	(ABC) transporter
D0812_RS25315	COG1720	tRNA m6t6A37 methyltransferase activity
D0812_RS25335	COG0589	response to stress
D0812_RS25360	COG1175	transmembrane transport
D0812_RS25365	COG0395	ABC-type sugar transport system, permease component
D0812_RS25370	COG3842	ATPase activity
D0812_RS25410	COG0523	cobalamin synthesis protein
D0812_RS25420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0812_RS25430	COG4667	esterase of the alpha-beta hydrolase superfamily
D0812_RS25440	COG1741	Belongs to the pirin family
D0812_RS25445	COG1278	Cold shock
D0812_RS25460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0812_RS25465	COG3706	GGDEF domain
D0812_RS25490	COG2226	methyltransferase
D0812_RS25500	COG3706	GGDEF domain
D0812_RS25505	COG1686	Belongs to the peptidase S11 family
D0812_RS25510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_RS25515	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0812_RS25525	COG0625	glutathione transferase activity
D0812_RS25535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0812_RS25545	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS25570	COG3746	phosphate-selective porin O and P
D0812_RS25585	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS25595	COG0583	DNA-binding transcription factor activity
D0812_RS25600	COG2207	Transcriptional regulator
D0812_RS25600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0812_RS25605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0812_RS25635	COG0513	Belongs to the DEAD box helicase family
D0812_RS25645	COG0583	DNA-binding transcription factor activity
D0812_RS25670	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS25675	COG2814	Major facilitator Superfamily
D0812_RS25685	COG1902	pentaerythritol trinitrate reductase activity
D0812_RS25700	COG3122	Protein conserved in bacteria
D0812_RS25705	COG0583	DNA-binding transcription factor activity
D0812_RS25725	COG0583	DNA-binding transcription factor activity
D0812_RS25730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0812_RS25745	COG0252	asparaginase activity
D0812_RS25755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0812_RS25755	COG0574	Belongs to the PEP-utilizing enzyme family
D0812_RS25765	COG2197	response regulator
D0812_RS25770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0812_RS25820	COG0583	DNA-binding transcription factor activity
D0812_RS25825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_RS25840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0812_RS25845	COG0786	glutamate:sodium symporter activity
D0812_RS25880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_RS25885	COG0318	PFAM AMP-dependent synthetase and ligase
D0812_RS25905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_RS25920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_RS25930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0812_RS25975	COG1621	beta-fructofuranosidase activity
D0812_RS25980	COG1263	PTS System
D0812_RS25980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS25985	COG2188	Transcriptional regulator
D0812_RS26000	COG4948	Mandelate Racemase Muconate Lactonizing
D0812_RS26045	COG1342	Belongs to the UPF0251 family
D0812_RS26055	COG4176	ABC-type proline glycine betaine transport system permease component
D0812_RS26060	COG4175	Glycine betaine
D0812_RS26060	COG3448	diguanylate cyclase activity
D0812_RS26075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0812_RS26080	COG0583	DNA-binding transcription factor activity
D0812_RS26130	COG1335	isochorismatase
D0812_RS26145	COG0753	catalase activity
D0812_RS26165	COG1482	cell wall glycoprotein biosynthetic process
D0812_RS26170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0812_RS26175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS26175	COG1263	PTS System
D0812_RS26180	COG1609	Transcriptional regulator
D0812_RS26185	COG1349	DNA-binding transcription factor activity
D0812_RS26190	COG0346	lactoylglutathione lyase activity
D0812_RS26195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_RS26195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_RS26210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_RS26215	COG3537	Alpha-1,2-mannosidase
D0812_RS26220	COG3537	Alpha-1,2-mannosidase
D0812_RS26230	COG3537	Alpha-1,2-mannosidase
D0812_RS26235	COG3537	Alpha-1,2-mannosidase
D0812_RS26240	COG0737	Belongs to the 5'-nucleotidase family
D0812_RS26270	COG1280	lysine exporter protein (LysE YggA)
D0812_RS26275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0812_RS26290	COG3226	Transcriptional regulator
D0812_RS26305	COG0583	DNA-binding transcription factor activity
D0812_RS26320	COG0488	(ABC) transporter
D0812_RS26335	COG0431	NADPH-dependent FMN reductase
D0812_RS26340	COG0583	DNA-binding transcription factor activity
D0812_RS26345	COG4628	conserved protein (DUF2132)
D0812_RS26350	COG0488	(ABC) transporter
D0812_RS26365	COG0346	lactoylglutathione lyase activity
D0812_RS26370	COG0384	phenazine biosynthesis protein PhzF
D0812_RS26385	COG3220	belongs to the UPF0276 family
D0812_RS26400	COG1271	oxidase subunit
D0812_RS26405	COG1294	oxidase, subunit
D0812_RS26450	COG2207	Transcriptional regulator
D0812_RS26460	COG1882	Formate acetyltransferase
D0812_RS26465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0812_RS26470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0812_RS26485	COG2205	protein histidine kinase activity
D0812_RS26490	COG0745	RESPONSE REGULATOR receiver
D0812_RS26500	COG0454	-acetyltransferase
D0812_RS26505	COG0148	phosphopyruvate hydratase activity
D0812_RS26515	COG2814	Major facilitator Superfamily
D0812_RS26530	COG2988	succinylglutamate desuccinylase activity
D0812_RS26570	COG0628	permease
D0812_RS26575	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0812_RS26590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0812_RS26600	COG4628	conserved protein (DUF2132)
D0812_RS26605	COG0583	DNA-binding transcription factor activity
D0812_RS26630	COG1686	Belongs to the peptidase S11 family
D0812_RS26650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0812_RS26655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0812_RS26680	COG0415	Belongs to the DNA photolyase family
D0812_RS26685	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D0812_RS26695	COG4667	esterase of the alpha-beta hydrolase superfamily
D0812_RS26700	COG2095	MarC family integral membrane protein
D0812_RS26735	COG0583	DNA-binding transcription factor activity
D0812_RS26740	COG2814	Major facilitator Superfamily
D0812_RS26770	COG1301	dicarboxylic acid transport
D0812_RS26775	COG3339	Conserved Protein
D0812_RS26780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0812_RS26785	COG0700	Nucleoside recognition
D0812_RS26790	COG3366	ferrous iron transmembrane transporter activity
D0812_RS26805	COG0366	Alpha amylase catalytic
D0812_RS26815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0812_RS26820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0812_RS26825	COG1640	4-alpha-glucanotransferase
D0812_RS26830	COG0058	SHG alpha-glucan phosphorylase activity
D0812_RS26850	COG1999	signal sequence binding
D0812_RS26865	COG1162	GTPase activity
D0812_RS26870	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D0812_RS26875	COG0673	inositol 2-dehydrogenase activity
D0812_RS26900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS26905	COG0673	inositol 2-dehydrogenase activity
D0812_RS26910	COG3962	Belongs to the TPP enzyme family
D0812_RS26920	COG0477	Major facilitator Superfamily
D0812_RS26920	COG2814	Major facilitator Superfamily
D0812_RS26940	COG0183	Belongs to the thiolase family
D0812_RS26945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D0812_RS26970	COG0531	amino acid
D0812_RS26975	COG1982	Orn Lys Arg decarboxylase major
D0812_RS26995	COG2356	endonuclease I
D0812_RS27030	COG2203	Gaf domain
D0812_RS27030	COG2199	diguanylate cyclase activity
D0812_RS27055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0812_RS27070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS27070	COG1263	PTS System
D0812_RS27075	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_RS27080	COG1760	l-serine dehydratase
D0812_RS27105	COG1609	Transcriptional regulator
D0812_RS27115	COG2814	Major facilitator Superfamily
D0812_RS27120	COG3214	Protein conserved in bacteria
D0812_RS27130	COG4771	TonB-dependent receptor
D0812_RS27135	COG0583	DNA-binding transcription factor activity
D0812_RS27140	COG4607	ABC-type enterochelin transport system periplasmic component
D0812_RS27150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_RS27155	COG4605	iron ion homeostasis
D0812_RS27160	COG4604	ABC transporter, ATP-binding protein
D0812_RS27190	COG0739	heme binding
D0812_RS27205	COG0800	Aldolase
D0812_RS27210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS27215	COG2190	(PTS) system
D0812_RS27215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS27215	COG1263	PTS System
D0812_RS27225	COG2188	Transcriptional regulator
D0812_RS27235	COG1621	beta-fructofuranosidase activity
D0812_RS27245	COG3842	ATPase activity
D0812_RS27250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_RS27255	COG1554	hydrolase, family 65, central catalytic
D0812_RS27260	COG0395	ABC-type sugar transport system, permease component
D0812_RS27265	COG1175	transmembrane transport
D0812_RS27295	COG3121	Chaperone
D0812_RS27300	COG3188	usher protein
D0812_RS27330	COG0612	Peptidase, M16
D0812_RS27335	COG0840	transmembrane signaling receptor activity
D0812_RS27350	COG0826	peptidase U32
D0812_RS27380	COG2842	Transposition protein
D0812_RS27410	COG3081	Nucleoid-associated protein
D0812_RS27465	COG3409	Peptidoglycan-binding domain 1 protein
D0812_RS27465	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0812_RS27610	COG0667	Aldo Keto reductase
D0812_RS27620	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0812_RS27625	COG0666	response to abiotic stimulus
D0812_RS27630	COG0583	DNA-binding transcription factor activity
D0812_RS27640	COG1136	(ABC) transporter
D0812_RS27645	COG0577	efflux transmembrane transporter activity
D0812_RS27690	COG1764	response to oxidative stress
D0812_RS27695	COG1846	Transcriptional regulator
D0812_RS27705	COG3634	alkyl hydroperoxide reductase activity
D0812_RS27725	COG2188	Transcriptional regulator
D0812_RS27730	COG2271	Major facilitator Superfamily
D0812_RS27735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS27740	COG1397	ADP-ribosylglycohydrolase
D0812_RS27745	COG2211	Major facilitator Superfamily
D0812_RS27765	COG0346	lactoylglutathione lyase activity
D0812_RS27770	COG0840	transmembrane signaling receptor activity
D0812_RS27780	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D0812_RS27790	COG1522	sequence-specific DNA binding
D0812_RS27805	COG2258	MOSC domain
D0812_RS27810	COG1609	Transcriptional regulator
D0812_RS27815	COG1757	Na H antiporter
D0812_RS27820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0812_RS27825	COG0513	Belongs to the DEAD box helicase family
D0812_RS27845	COG1595	DNA-templated transcription, initiation
D0812_RS27855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0812_RS27860	COG1312	Catalyzes the dehydration of D-mannonate
D0812_RS27865	COG2186	Transcriptional regulator
D0812_RS27875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0812_RS27885	COG0246	Mannitol dehydrogenase
D0812_RS27890	COG1904	glucuronate isomerase
D0812_RS27895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_RS27900	COG0800	Aldolase
D0812_RS27915	COG0549	Belongs to the carbamate kinase family
D0812_RS27920	COG0531	amino acid
D0812_RS27925	COG2957	Belongs to the agmatine deiminase family
D0812_RS27950	COG1132	(ABC) transporter
D0812_RS27975	COG0406	alpha-ribazole phosphatase activity
D0812_RS28070	COG4166	transmembrane transport
D0812_RS28085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0812_RS28090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_RS28090	COG1263	PTS System
D0812_RS28095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0812_RS28120	COG1444	tRNA N-acetyltransferase activity
D0812_RS28155	COG4608	Belongs to the ABC transporter superfamily
D0812_RS28160	COG0444	Belongs to the ABC transporter superfamily
D0812_RS28170	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D0812_RS28170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0812_RS28195	COG0772	Belongs to the SEDS family
D0812_RS28210	COG1566	PFAM secretion protein HlyD family protein
D0812_RS28215	COG0583	DNA-binding transcription factor activity
D0812_RS28225	COG1136	(ABC) transporter
D0812_RS28245	COG3275	phosphorelay sensor kinase activity
D0812_RS28250	COG3279	Response regulator of the LytR AlgR family
D0812_RS28260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0812_RS28285	COG0786	glutamate:sodium symporter activity
D0812_RS28300	COG1131	(ABC) transporter
D0812_RS28305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0812_RS28310	COG0786	glutamate:sodium symporter activity
D0812_RS28335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0812_RS28350	COG0829	nickel cation binding
D0812_RS28355	COG0831	urea catabolic process
D0812_RS28360	COG0832	Belongs to the urease beta subunit family
D0812_RS28365	COG0804	urea catabolic process
D0812_RS28370	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D0812_RS28375	COG0830	nickel cation binding
D0812_RS28380	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0812_RS28390	COG2207	Transcriptional regulator
D0812_RS28395	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D0812_RS28405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_RS28425	COG0251	oxidation-reduction process
D0812_RS28430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0812_RS28480	COG0561	phosphatase activity
D0812_RS28485	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D0812_RS28490	COG3623	hexulose-6-phosphate isomerase
D0812_RS28530	COG1741	Belongs to the pirin family
D0812_RS28535	COG2259	Doxx family
D0812_RS28545	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D0812_RS28550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0812_RS28560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0812_RS28695	COG5001	Diguanylate cyclase
D0812_RS28700	COG4580	involved in the transport of maltose and maltodextrins
D0812_RS28705	COG1609	Transcriptional regulator
D0812_RS28720	COG0395	ABC-type sugar transport system, permease component
D0812_RS28725	COG2723	6-phospho-beta-galactosidase activity
D0812_RS28730	COG3842	ATPase activity
D0812_RS28735	COG1609	Transcriptional regulator
D0812_RS28740	COG0534	Mate efflux family protein
D0812_RS28745	COG0564	pseudouridine synthase activity
D0812_RS28760	COG0561	phosphatase activity
D0812_RS28770	COG2199	diguanylate cyclase activity
D0812_RS28780	COG3152	Membrane
D0812_RS28795	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D0812_RS28800	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D0812_RS28815	COG0583	DNA-binding transcription factor activity
D0812_RS28860	COG2076	Multidrug Resistance protein
D0812_RS28875	COG1357	PFAM Pentapeptide repeats (8 copies)
D0812_RS28880	COG3047	cAMP biosynthetic process
D0812_RS28885	COG2358	TRAP transporter, solute receptor (TAXI family
D0812_RS28900	COG2814	Major facilitator Superfamily
D0812_RS28920	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0812_RS28920	COG3408	Glycogen debranching enzyme
D0812_RS28950	COG0583	DNA-binding transcription factor activity
D0812_RS28990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0812_RS29025	COG1228	amidohydrolase
D0812_RS29055	COG1192	Involved in chromosome partitioning
D0812_RS29085	COG5268	conjugation
D0812_RS29090	COG3451	type IV secretory pathway VirB4
D0812_RS29100	COG4962	Type ii secretion system protein e
D0812_RS29120	COG3504	Conjugal transfer protein
D0812_RS29130	COG2948	multi-organism process
D0812_RS29155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0812_RS29230	COG2801	Transposase and inactivated derivatives
D0812_RS29255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0812_RS29335	COG0768	penicillin binding
D0812_RS29370	COG1192	Involved in chromosome partitioning
D0812_RS29400	COG1396	sequence-specific DNA binding
D0812_RS29410	COG5268	conjugation
D0812_RS29415	COG3451	type IV secretory pathway VirB4
D0812_RS29425	COG4962	Type ii secretion system protein e
D0812_RS29485	COG0739	heme binding
D0812_RS29500	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D0812_RS29520	COG4932	domain protein
D0812_RS29520	COG5492	domain, Protein
D0812_RS29545	COG4974	Belongs to the 'phage' integrase family
D0812_RS29555	COG2337	Toxic component of a toxin-antitoxin (TA) module
D0812_RS29610	COG2885	chlorophyll binding
D0812_RS29645	COG4932	domain protein
D0812_RS29645	COG5492	domain, Protein
D0812_RS29785	COG4962	Type ii secretion system protein e
D0812_RS29820	COG3504	Conjugal transfer protein
D0812_RS29835	COG4962	Type ii secretion system protein e
D0812_RS29845	COG3451	type IV secretory pathway VirB4
D0812_RS29850	COG5268	conjugation
D0812_RS29880	COG1192	Involved in chromosome partitioning
D0812_RS29905	COG0419	ATPase involved in DNA repair