locus-tag	class	description
DR996_RS00005	COG4397	Mu-like prophage major head subunit gpT
DR996_RS00020	COG3941	tape measure
DR996_RS00030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DR996_RS00040	COG3064	Membrane
DR996_RS00065	COG3300	MHYT domain
DR996_RS00065	COG5001	Diguanylate cyclase
DR996_RS00070	COG4999	Histidine kinase
DR996_RS00070	COG3850	Histidine kinase
DR996_RS00070	COG3437	response regulator, receiver
DR996_RS00070	COG2205	protein histidine kinase activity
DR996_RS00090	COG0110	maltose O-acetyltransferase activity
DR996_RS00095	COG2205	protein histidine kinase activity
DR996_RS00095	COG0784	Response regulator, receiver
DR996_RS00120	COG2315	Protein conserved in bacteria
DR996_RS00125	COG1846	Transcriptional regulator
DR996_RS00135	COG1482	cell wall glycoprotein biosynthetic process
DR996_RS00150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_RS00170	COG0383	alpha-mannosidase activity
DR996_RS00180	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DR996_RS00210	COG3247	response to pH
DR996_RS00215	COG0668	transmembrane transport
DR996_RS00230	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DR996_RS00245	COG0745	RESPONSE REGULATOR receiver
DR996_RS00295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_RS00295	COG2199	diguanylate cyclase activity
DR996_RS00300	COG0519	Catalyzes the synthesis of GMP from XMP
DR996_RS00305	COG0589	response to stress
DR996_RS00320	COG0583	DNA-binding transcription factor activity
DR996_RS00335	COG3083	sulfuric ester hydrolase activity
DR996_RS00345	COG0583	DNA-binding transcription factor activity
DR996_RS00350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS00360	COG0583	DNA-binding transcription factor activity
DR996_RS00365	COG0668	transmembrane transport
DR996_RS00370	COG0668	transmembrane transport
DR996_RS00390	COG5001	Diguanylate cyclase
DR996_RS00390	COG2203	Gaf domain
DR996_RS00390	COG4251	negative regulation of phosphorylation
DR996_RS00390	COG3706	GGDEF domain
DR996_RS00500	COG0657	acetylesterase activity
DR996_RS00510	COG0625	glutathione transferase activity
DR996_RS00520	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DR996_RS00535	COG2195	Cleaves the N-terminal amino acid of tripeptides
DR996_RS00545	COG0601	transmembrane transport
DR996_RS00550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_RS00555	COG0444	Belongs to the ABC transporter superfamily
DR996_RS00575	COG3291	Pkd domain containing protein
DR996_RS00595	COG0813	purine-nucleoside phosphorylase activity
DR996_RS00600	COG1177	transmembrane transport
DR996_RS00610	COG3842	ATPase activity
DR996_RS00615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DR996_RS00620	COG2423	ornithine cyclodeaminase activity
DR996_RS00630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR996_RS00635	COG3938	Belongs to the proline racemase family
DR996_RS00665	COG1451	nucleotide metabolic process
DR996_RS00670	COG5492	domain, Protein
DR996_RS00670	COG4932	domain protein
DR996_RS00685	COG2201	protein-glutamate methylesterase activity
DR996_RS00695	COG2205	protein histidine kinase activity
DR996_RS00695	COG0784	Response regulator, receiver
DR996_RS00755	COG4968	Prepilin-type N-terminal cleavage methylation domain
DR996_RS00765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS00780	COG0583	DNA-binding transcription factor activity
DR996_RS00810	COG4139	cobalamin transport
DR996_RS00825	COG2062	phosphohistidine phosphatase, SixA
DR996_RS00835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DR996_RS00845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DR996_RS00850	COG0702	epimerase
DR996_RS00865	COG2925	Exonuclease
DR996_RS00875	COG1346	cytolysis
DR996_RS00920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS00925	COG1621	beta-fructofuranosidase activity
DR996_RS00935	COG0072	phenylalanine-tRNA ligase activity
DR996_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR996_RS00945	COG3706	GGDEF domain
DR996_RS00985	COG0251	oxidation-reduction process
DR996_RS01005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DR996_RS01030	COG2188	Transcriptional regulator
DR996_RS01040	COG0010	Belongs to the arginase family
DR996_RS01050	COG2986	histidine ammonia-lyase
DR996_RS01065	COG0277	FAD linked oxidase domain protein
DR996_RS01065	COG0247	lactate metabolic process
DR996_RS01120	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
DR996_RS01125	COG1643	Atp-dependent helicase
DR996_RS01135	COG2949	membrane
DR996_RS01140	COG0471	metal ion transport
DR996_RS01145	COG3706	GGDEF domain
DR996_RS01165	COG0492	ferredoxin-NADP+ reductase activity
DR996_RS01170	COG4988	ABC transporter
DR996_RS01175	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DR996_RS01185	COG0583	DNA-binding transcription factor activity
DR996_RS01190	COG2200	EAL domain
DR996_RS01230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DR996_RS01240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_RS01240	COG4191	Histidine kinase
DR996_RS01255	COG3070	regulator of competence-specific genes
DR996_RS01265	COG2431	L-lysine efflux transmembrane transporter activity
DR996_RS01275	COG0076	glutamate decarboxylase activity
DR996_RS01280	COG1737	Transcriptional regulator
DR996_RS01290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DR996_RS01300	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DR996_RS01335	COG4181	ATPase activity
DR996_RS01340	COG0534	Mate efflux family protein
DR996_RS01345	COG0702	epimerase
DR996_RS01350	COG4667	esterase of the alpha-beta hydrolase superfamily
DR996_RS01360	COG2814	Major facilitator Superfamily
DR996_RS01365	COG1187	pseudouridine synthase activity
DR996_RS01370	COG1061	Type III restriction enzyme res subunit
DR996_RS01375	COG2199	diguanylate cyclase activity
DR996_RS01385	COG0745	RESPONSE REGULATOR receiver
DR996_RS01390	COG2205	protein histidine kinase activity
DR996_RS01430	COG3313	Fe-S protein
DR996_RS01440	COG0659	secondary active sulfate transmembrane transporter activity
DR996_RS01465	COG0493	'glutamate synthase
DR996_RS01475	COG0398	Pfam SNARE associated Golgi protein
DR996_RS01480	COG4134	Bacterial extracellular solute-binding protein
DR996_RS01485	COG4135	transport system, permease component
DR996_RS01490	COG4136	ATPase activity
DR996_RS01495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DR996_RS01505	COG3604	Transcriptional regulator
DR996_RS01510	COG1151	hydroxylamine reductase activity
DR996_RS01515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR996_RS01525	COG0564	pseudouridine synthase activity
DR996_RS01535	COG0733	neurotransmitter:sodium symporter activity
DR996_RS01545	COG0626	cystathionine gamma-synthase activity
DR996_RS01550	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DR996_RS01555	COG5380	lipid catabolic process
DR996_RS01560	COG2818	Glycosylase
DR996_RS01580	COG1983	PspC domain protein
DR996_RS01590	COG1842	Phage shock protein A
DR996_RS01595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DR996_RS01605	COG4168	peptide transport system, permease
DR996_RS01610	COG4171	peptide transport system, permease
DR996_RS01620	COG4172	Belongs to the ABC transporter superfamily
DR996_RS01630	COG1227	inorganic diphosphatase activity
DR996_RS01645	COG0243	molybdopterin cofactor binding
DR996_RS01650	COG3005	denitrification pathway
DR996_RS01655	COG4459	periplasmic nitrate reductase
DR996_RS01660	COG0390	transport system, permease component
DR996_RS01670	COG2116	formate transmembrane transporter activity
DR996_RS01695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DR996_RS01700	COG1435	thymidine kinase activity
DR996_RS01705	COG0215	cysteine-tRNA ligase activity
DR996_RS01710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DR996_RS01715	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DR996_RS01720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DR996_RS01725	COG3012	SEC-C Motif Domain Protein
DR996_RS01730	COG0140	phosphoribosyl-ATP diphosphatase activity
DR996_RS01730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DR996_RS01740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DR996_RS01745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DR996_RS01750	COG0131	Imidazoleglycerol-phosphate dehydratase
DR996_RS01750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DR996_RS01760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DR996_RS01770	COG1757	Na H antiporter
DR996_RS01780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS01800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DR996_RS01810	COG2268	Band 7 protein
DR996_RS01820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DR996_RS01835	COG0300	oxidoreductase activity
DR996_RS01860	COG2226	methyltransferase
DR996_RS01880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DR996_RS01900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DR996_RS01910	COG1674	ftsk spoiiie
DR996_RS01920	COG0686	Belongs to the AlaDH PNT family
DR996_RS01930	COG0583	DNA-binding transcription factor activity
DR996_RS01950	COG0800	Aldolase
DR996_RS01955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS01960	COG1917	Cupin 2, conserved barrel domain protein
DR996_RS01990	COG0402	S-adenosylhomocysteine deaminase activity
DR996_RS01995	COG4934	collagen metabolic process
DR996_RS02020	COG3568	Endonuclease Exonuclease Phosphatase
DR996_RS02075	COG2186	Transcriptional regulator
DR996_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS02085	COG2186	Transcriptional regulator
DR996_RS02090	COG0517	IMP dehydrogenase activity
DR996_RS02095	COG2176	DNA-directed DNA polymerase activity
DR996_RS02100	COG0697	spore germination
DR996_RS02105	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DR996_RS02120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR996_RS02145	COG1120	ATPase activity
DR996_RS02150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_RS02155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_RS02175	COG1288	antiporter activity
DR996_RS02185	COG2186	Transcriptional regulator
DR996_RS02195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_RS02200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS02225	COG0747	negative chemotaxis
DR996_RS02230	COG4608	Belongs to the ABC transporter superfamily
DR996_RS02235	COG0444	Belongs to the ABC transporter superfamily
DR996_RS02240	COG0534	Mate efflux family protein
DR996_RS02265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR996_RS02270	COG2824	Alkylphosphonate utilization operon protein PhnA
DR996_RS02275	COG2723	6-phospho-beta-galactosidase activity
DR996_RS02280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS02280	COG1263	PTS System
DR996_RS02295	COG3119	arylsulfatase activity
DR996_RS02335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DR996_RS02375	COG2003	Belongs to the UPF0758 family
DR996_RS02390	COG3778	Protein conserved in bacteria
DR996_RS02425	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
DR996_RS02435	COG4386	tail sheath protein
DR996_RS02465	COG4397	Mu-like prophage major head subunit gpT
DR996_RS02485	COG2369	cell adhesion
DR996_RS02490	COG4383	Mu-like prophage protein gp29
DR996_RS02495	COG4373	Mu-like prophage FluMu protein gp28
DR996_RS02525	COG4382	Mu-like prophage protein Gp16
DR996_RS02605	COG3423	Transcriptional regulator
DR996_RS02640	COG4983	Phage plasmid primase, P4 family domain protein
DR996_RS02645	COG3311	Transcriptional regulator
DR996_RS02665	COG0582	viral genome integration into host DNA
DR996_RS02680	COG5002	protein histidine kinase activity
DR996_RS02680	COG0784	Response regulator, receiver
DR996_RS02690	COG0754	glutathionylspermidine amidase activity
DR996_RS02700	COG3766	membrane
DR996_RS02715	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DR996_RS02720	COG2885	chlorophyll binding
DR996_RS02725	COG0823	Involved in the tonB-independent uptake of proteins
DR996_RS02740	COG0811	peptide transport
DR996_RS02745	COG0824	Thioesterase
DR996_RS02755	COG4890	Cyd operon protein YbgT
DR996_RS02760	COG1294	oxidase, subunit
DR996_RS02765	COG1271	oxidase subunit
DR996_RS02775	COG0632	four-way junction helicase activity
DR996_RS02780	COG0840	transmembrane signaling receptor activity
DR996_RS02795	COG1801	Protein of unknown function DUF72
DR996_RS02810	COG4067	protein conserved in archaea
DR996_RS02810	COG0189	ligase activity
DR996_RS02835	COG0318	PFAM AMP-dependent synthetase and ligase
DR996_RS02850	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DR996_RS02855	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
DR996_RS02865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR996_RS02870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DR996_RS02875	COG0745	RESPONSE REGULATOR receiver
DR996_RS02890	COG3070	regulator of competence-specific genes
DR996_RS02910	COG0297	glycogen (starch) synthase activity
DR996_RS02915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DR996_RS02920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR996_RS02950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DR996_RS02955	COG0542	response to heat
DR996_RS02965	COG1278	Cold shock
DR996_RS02975	COG1187	pseudouridine synthase activity
DR996_RS02980	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DR996_RS02990	COG1199	ATP-dependent helicase activity
DR996_RS02995	COG0730	response to heat
DR996_RS03000	COG3923	Primosomal replication protein n
DR996_RS03010	COG0840	transmembrane signaling receptor activity
DR996_RS03015	COG0708	Exodeoxyribonuclease III
DR996_RS03025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS03065	COG1882	Formate acetyltransferase
DR996_RS03075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DR996_RS03090	COG2766	serine protein kinase
DR996_RS03095	COG2718	Belongs to the UPF0229 family
DR996_RS03100	COG2719	SpoVR family
DR996_RS03120	COG1132	(ABC) transporter
DR996_RS03125	COG2333	competence protein COMEC
DR996_RS03125	COG0658	competence protein
DR996_RS03135	COG4591	ABC-type transport system involved in lipoprotein release permease component
DR996_RS03140	COG1136	(ABC) transporter
DR996_RS03145	COG4591	ABC-type transport system involved in lipoprotein release permease component
DR996_RS03155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DR996_RS03170	COG1252	NADH dehydrogenase
DR996_RS03200	COG0537	adenosine 5'-monophosphoramidase activity
DR996_RS03205	COG0840	transmembrane signaling receptor activity
DR996_RS03220	COG2217	Heavy metal translocating P-type atpase
DR996_RS03230	COG0517	IMP dehydrogenase activity
DR996_RS03230	COG0516	GMP reductase activity
DR996_RS03235	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DR996_RS03240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DR996_RS03245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR996_RS03250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DR996_RS03260	COG2199	diguanylate cyclase activity
DR996_RS03275	COG3126	Type III secretion system lipoprotein chaperone (YscW)
DR996_RS03280	COG1946	Acyl-CoA thioesterase
DR996_RS03290	COG1522	sequence-specific DNA binding
DR996_RS03310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_RS03365	COG2855	membrane
DR996_RS03375	COG0583	DNA-binding transcription factor activity
DR996_RS03380	COG1263	PTS System
DR996_RS03380	COG2190	(PTS) system
DR996_RS03380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS03395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DR996_RS03400	COG0596	Alpha beta hydrolase
DR996_RS03410	COG1169	isochorismate synthase
DR996_RS03415	COG0436	Aminotransferase
DR996_RS03420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DR996_RS03440	COG1555	photosystem II stabilization
DR996_RS03445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR996_RS03450	COG0776	regulation of translation
DR996_RS03455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DR996_RS03485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DR996_RS03490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DR996_RS03495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DR996_RS03515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR996_RS03520	COG0569	domain protein
DR996_RS03525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_RS03530	COG0513	Belongs to the DEAD box helicase family
DR996_RS03535	COG1253	flavin adenine dinucleotide binding
DR996_RS03540	COG4771	TonB-dependent receptor
DR996_RS03555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DR996_RS03555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DR996_RS03560	COG1535	isochorismatase
DR996_RS03560	COG3433	isochorismatase activity
DR996_RS03565	COG1021	2,3-dihydroxybenzoate-AMP ligase
DR996_RS03570	COG1169	isochorismate synthase
DR996_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS03590	COG2226	methyltransferase
DR996_RS03605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_RS03615	COG2951	lytic endotransglycosylase activity
DR996_RS03630	COG2894	cell division
DR996_RS03635	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DR996_RS03640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DR996_RS03645	COG0318	PFAM AMP-dependent synthetase and ligase
DR996_RS03650	COG2267	carboxylic ester hydrolase activity
DR996_RS03655	COG3065	identical protein binding
DR996_RS03665	COG1214	PFAM Peptidase M22, glycoprotease
DR996_RS03670	COG1199	ATP-dependent helicase activity
DR996_RS03675	COG0788	formyltetrahydrofolate deformylase activity
DR996_RS03690	COG3102	Protein conserved in bacteria
DR996_RS03715	COG1918	ferrous iron import across plasma membrane
DR996_RS03720	COG4977	sequence-specific DNA binding
DR996_RS03725	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DR996_RS03730	COG1121	(ABC) transporter
DR996_RS03735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DR996_RS03750	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR996_RS03755	COG0567	Dehydrogenase, E1 component
DR996_RS03765	COG1053	succinate dehydrogenase
DR996_RS03770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DR996_RS03785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DR996_RS03795	COG0033	Phosphoglucomutase
DR996_RS03805	COG0596	Alpha beta hydrolase
DR996_RS03825	COG0735	belongs to the Fur family
DR996_RS03830	COG2165	general secretion pathway protein
DR996_RS03840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS03840	COG1263	PTS System
DR996_RS03840	COG2190	(PTS) system
DR996_RS03845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DR996_RS03850	COG1846	Transcriptional regulator
DR996_RS03850	COG1940	carbohydrate kinase activity
DR996_RS03855	COG4651	solute:proton antiporter activity
DR996_RS03855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DR996_RS03860	COG0367	asparagine synthase
DR996_RS03865	COG0250	Participates in transcription elongation, termination and antitermination
DR996_RS03870	COG3104	oligopeptide transport
DR996_RS03875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DR996_RS03890	COG3710	Transcriptional regulator
DR996_RS03910	COG0622	Phosphoesterase
DR996_RS03940	COG1090	epimerase
DR996_RS03945	COG0300	oxidoreductase activity
DR996_RS03955	COG3118	belongs to the thioredoxin family
DR996_RS03965	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DR996_RS03970	COG1215	transferase activity, transferring glycosyl groups
DR996_RS03975	COG1215	transferase activity, transferring glycosyl groups
DR996_RS04000	COG2194	sulfuric ester hydrolase activity
DR996_RS04005	COG0330	HflC and HflK could
DR996_RS04045	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
DR996_RS04050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DR996_RS04055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS04060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DR996_RS04065	COG2190	(PTS) system
DR996_RS04070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_RS04075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_RS04080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_RS04095	COG1705	Flagellar rod assembly protein muramidase FlgJ
DR996_RS04095	COG3951	Flagellar rod assembly protein muramidase FlgJ
DR996_RS04100	COG1706	bacterial-type flagellum-dependent cell motility
DR996_RS04105	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DR996_RS04115	COG4787	bacterial-type flagellum-dependent cell motility
DR996_RS04120	COG1749	Flagellar hook protein flgE
DR996_RS04130	COG1558	bacterial-type flagellum-dependent cell motility
DR996_RS04135	COG1815	bacterial-type flagellum-dependent cell motility
DR996_RS04140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DR996_RS04145	COG0784	Response regulator, receiver
DR996_RS04145	COG0835	chemotaxis
DR996_RS04200	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DR996_RS04210	COG2608	mercury ion transmembrane transporter activity
DR996_RS04210	COG2217	Heavy metal translocating P-type atpase
DR996_RS04245	COG2840	Smr protein MutS2
DR996_RS04250	COG1187	pseudouridine synthase activity
DR996_RS04255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DR996_RS04260	COG0737	Belongs to the 5'-nucleotidase family
DR996_RS04270	COG2912	Transglutaminase-like superfamily
DR996_RS04275	COG3094	Invasion gene expression up-regulator, SirB
DR996_RS04280	COG2890	protein-(glutamine-N5) methyltransferase activity
DR996_RS04305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DR996_RS04430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_RS04440	COG1702	phosphate starvation-inducible protein PhoH
DR996_RS04450	COG4535	Mg2 and Co2 transporter CorC
DR996_RS04455	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DR996_RS04460	COG2888	peptidyl-tyrosine sulfation
DR996_RS04465	COG0495	leucyl-tRNA aminoacylation
DR996_RS04470	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DR996_RS04475	COG1466	dna polymerase III delta subunit
DR996_RS04480	COG0799	negative regulation of ribosome biogenesis
DR996_RS04490	COG0768	penicillin binding
DR996_RS04495	COG0772	Belongs to the SEDS family
DR996_RS04500	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DR996_RS04505	COG1686	Belongs to the peptidase S11 family
DR996_RS04525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DR996_RS04530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DR996_RS04545	COG0366	Alpha amylase catalytic
DR996_RS04550	COG1263	PTS System
DR996_RS04550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS04560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DR996_RS04565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DR996_RS04570	COG2011	ABC-type metal ion transport system permease component
DR996_RS04575	COG1464	Belongs to the NlpA lipoprotein family
DR996_RS04585	COG0737	Belongs to the 5'-nucleotidase family
DR996_RS04590	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
DR996_RS04615	COG1611	Belongs to the LOG family
DR996_RS04630	COG2363	Small membrane protein
DR996_RS04640	COG0583	DNA-binding transcription factor activity
DR996_RS04655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DR996_RS04665	COG0142	geranyltranstransferase activity
DR996_RS04675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DR996_RS04680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DR996_RS04705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DR996_RS04705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DR996_RS04710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DR996_RS04715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DR996_RS04740	COG2252	PERMEase
DR996_RS04745	COG2195	Cleaves the N-terminal amino acid of tripeptides
DR996_RS04775	COG0047	phosphoribosylformylglycinamidine synthase activity
DR996_RS04775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DR996_RS04785	COG0590	tRNA wobble adenosine to inosine editing
DR996_RS04790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DR996_RS04810	COG4969	Belongs to the N-Me-Phe pilin family
DR996_RS04840	COG1301	dicarboxylic acid transport
DR996_RS04860	COG0497	DNA recombination
DR996_RS04865	COG0456	acetyltransferase
DR996_RS04870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR996_RS04880	COG2914	Belongs to the UPF0125 (RnfH) family
DR996_RS04885	COG2867	negative regulation of translational initiation
DR996_RS04900	COG0583	DNA-binding transcription factor activity
DR996_RS04905	COG1289	transmembrane transporter activity
DR996_RS04925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DR996_RS04930	COG2873	o-acetylhomoserine
DR996_RS04945	COG0583	DNA-binding transcription factor activity
DR996_RS04955	COG1115	amino acid carrier protein
DR996_RS04960	COG1584	GPR1 FUN34 yaaH family protein
DR996_RS04970	COG1757	Na H antiporter
DR996_RS04980	COG0517	IMP dehydrogenase activity
DR996_RS04980	COG0516	GMP reductase activity
DR996_RS04995	COG2199	diguanylate cyclase activity
DR996_RS04995	COG2203	Gaf domain
DR996_RS05005	COG1160	GTP binding
DR996_RS05010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR996_RS05015	COG2976	Protein conserved in bacteria
DR996_RS05050	COG2975	iron-sulfur cluster assembly
DR996_RS05055	COG0633	Ferredoxin
DR996_RS05070	COG0316	Belongs to the HesB IscA family
DR996_RS05075	COG0822	iron-sulfur transferase activity
DR996_RS05090	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DR996_RS05095	COG0483	inositol monophosphate 1-phosphatase activity
DR996_RS05100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR996_RS05105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR996_RS05110	COG1862	Preprotein translocase
DR996_RS05135	COG0517	IMP dehydrogenase activity
DR996_RS05145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DR996_RS05150	COG0583	DNA-binding transcription factor activity
DR996_RS05155	COG0450	alkyl hydroperoxide reductase
DR996_RS05185	COG0704	Plays a role in the regulation of phosphate uptake
DR996_RS05190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DR996_RS05195	COG0581	inorganic phosphate transmembrane transporter activity
DR996_RS05205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DR996_RS05210	COG0248	Ppx GppA phosphatase
DR996_RS05220	COG5002	protein histidine kinase activity
DR996_RS05225	COG0745	RESPONSE REGULATOR receiver
DR996_RS05240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DR996_RS05265	COG3069	C4-dicarboxylate transmembrane transporter activity
DR996_RS05270	COG2195	Cleaves the N-terminal amino acid of tripeptides
DR996_RS05305	COG0328	RNA-DNA hybrid ribonuclease activity
DR996_RS05385	COG3501	Rhs element vgr protein
DR996_RS05540	COG2003	Belongs to the UPF0758 family
DR996_RS05545	COG4735	regulation of single-species biofilm formation
DR996_RS05555	COG0582	viral genome integration into host DNA
DR996_RS05590	COG0542	response to heat
DR996_RS05600	COG0564	pseudouridine synthase activity
DR996_RS05605	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR996_RS05610	COG0741	lytic transglycosylase activity
DR996_RS05615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DR996_RS05620	COG0077	Prephenate dehydratase
DR996_RS05620	COG1605	Chorismate mutase
DR996_RS05625	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DR996_RS05640	COG0488	(ABC) transporter
DR996_RS05650	COG0739	heme binding
DR996_RS05655	COG0287	Prephenate dehydrogenase
DR996_RS05655	COG1605	Chorismate mutase
DR996_RS05660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR996_RS05670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DR996_RS05690	COG1966	Carbon starvation protein
DR996_RS05695	COG3275	phosphorelay sensor kinase activity
DR996_RS05700	COG3279	Response regulator of the LytR AlgR family
DR996_RS05705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DR996_RS05710	COG1047	Peptidyl-prolyl cis-trans
DR996_RS05725	COG0196	riboflavin kinase activity
DR996_RS05730	COG0728	peptidoglycan biosynthetic process
DR996_RS05735	COG0268	Binds directly to 16S ribosomal RNA
DR996_RS05740	COG0640	Transcriptional regulator
DR996_RS05745	COG0583	DNA-binding transcription factor activity
DR996_RS05750	COG1283	sodium-dependent phosphate transmembrane transporter activity
DR996_RS05765	COG0730	response to heat
DR996_RS05790	COG0667	Aldo Keto reductase
DR996_RS05815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DR996_RS05820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_RS05825	COG4974	Belongs to the 'phage' integrase family
DR996_RS05830	COG0716	FMN binding
DR996_RS05845	COG0513	Belongs to the DEAD box helicase family
DR996_RS05855	COG3022	response to hydroperoxide
DR996_RS05860	COG1115	amino acid carrier protein
DR996_RS05890	COG0431	NADPH-dependent FMN reductase
DR996_RS05895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DR996_RS05900	COG0083	homoserine kinase activity
DR996_RS05915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DR996_RS05925	COG0745	RESPONSE REGULATOR receiver
DR996_RS05935	COG5002	protein histidine kinase activity
DR996_RS05935	COG2198	Histidine kinase
DR996_RS05935	COG0784	Response regulator, receiver
DR996_RS05940	COG2203	Gaf domain
DR996_RS05940	COG3706	GGDEF domain
DR996_RS05940	COG4251	negative regulation of phosphorylation
DR996_RS05940	COG5001	Diguanylate cyclase
DR996_RS05945	COG1242	4 iron, 4 sulfur cluster binding
DR996_RS05950	COG0067	glutamate synthase
DR996_RS05950	COG0069	glutamate synthase activity
DR996_RS05950	COG0070	glutamate synthase
DR996_RS05960	COG0070	glutamate synthase
DR996_RS05960	COG0069	glutamate synthase activity
DR996_RS05960	COG0067	glutamate synthase
DR996_RS05965	COG0493	'glutamate synthase
DR996_RS05990	COG2860	membrane
DR996_RS05995	COG0583	DNA-binding transcription factor activity
DR996_RS06000	COG0730	response to heat
DR996_RS06015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DR996_RS06020	COG0505	Belongs to the CarA family
DR996_RS06030	COG0494	nUDIX hydrolase
DR996_RS06050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DR996_RS06055	COG0849	cell division
DR996_RS06060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DR996_RS06075	COG0772	Belongs to the SEDS family
DR996_RS06090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DR996_RS06095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DR996_RS06100	COG0768	penicillin binding
DR996_RS06105	COG3116	cell division
DR996_RS06120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DR996_RS06135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DR996_RS06140	COG2823	Periplasmic or secreted lipoprotein
DR996_RS06145	COG2969	positive regulation of protein catabolic process
DR996_RS06150	COG0625	glutathione transferase activity
DR996_RS06155	COG2857	Cytochrome c1
DR996_RS06160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DR996_RS06165	COG0723	plastoquinol--plastocyanin reductase activity
DR996_RS06180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DR996_RS06185	COG3105	Protein conserved in bacteria
DR996_RS06190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR996_RS06195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR996_RS06200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DR996_RS06210	COG3150	esterase
DR996_RS06220	COG3151	Protein conserved in bacteria
DR996_RS06225	COG0494	nUDIX hydrolase
DR996_RS06230	COG1538	Outer membrane efflux protein
DR996_RS06240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DR996_RS06250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DR996_RS06255	COG3025	triphosphatase activity
DR996_RS06260	COG1392	Phosphate transport regulator
DR996_RS06265	COG0306	phosphate transporter
DR996_RS06270	COG4991	sh3 domain protein
DR996_RS06275	COG0405	Gamma-glutamyltransferase
DR996_RS06285	COG3267	Type II secretory pathway component ExeA
DR996_RS06285	COG3409	Peptidoglycan-binding domain 1 protein
DR996_RS06300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DR996_RS06305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DR996_RS06315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DR996_RS06320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DR996_RS06325	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DR996_RS06330	COG1610	YqeY-like protein
DR996_RS06335	COG0358	DNA primase activity
DR996_RS06370	COG2213	PTS system mannitol-specific
DR996_RS06370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS06380	COG3722	fumarate hydratase activity
DR996_RS06385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR996_RS06390	COG5002	protein histidine kinase activity
DR996_RS06410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DR996_RS06415	COG1349	DNA-binding transcription factor activity
DR996_RS06420	COG0469	pyruvate kinase activity
DR996_RS06430	COG3706	GGDEF domain
DR996_RS06440	COG0028	Belongs to the TPP enzyme family
DR996_RS06445	COG1022	Amp-dependent synthetase and ligase
DR996_RS06450	COG0583	DNA-binding transcription factor activity
DR996_RS06475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DR996_RS06480	COG0473	3-isopropylmalate dehydrogenase activity
DR996_RS06500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DR996_RS06505	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DR996_RS06510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR996_RS06515	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DR996_RS06545	COG3610	response to peptide
DR996_RS06550	COG2966	Psort location CytoplasmicMembrane, score
DR996_RS06565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DR996_RS06570	COG0142	geranyltranstransferase activity
DR996_RS06590	COG2358	TRAP transporter, solute receptor (TAXI family
DR996_RS06605	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DR996_RS06610	COG1178	ABC-type Fe3 transport system permease component
DR996_RS06615	COG4143	(ABC) transporter
DR996_RS06620	COG0163	prenyltransferase activity
DR996_RS06625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DR996_RS06635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DR996_RS06650	COG2105	PFAM AIG2 family protein
DR996_RS06655	COG2911	Protein conserved in bacteria
DR996_RS06660	COG0729	surface antigen
DR996_RS06665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR996_RS06675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
DR996_RS06690	COG1136	(ABC) transporter
DR996_RS06710	COG0529	Catalyzes the synthesis of activated sulfate
DR996_RS06715	COG3273	potassium ion transport
DR996_RS06715	COG0471	metal ion transport
DR996_RS06730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DR996_RS06730	COG1648	precorrin-2 dehydrogenase activity
DR996_RS06735	COG0737	Belongs to the 5'-nucleotidase family
DR996_RS06750	COG0513	Belongs to the DEAD box helicase family
DR996_RS06755	COG2153	protein acetylation
DR996_RS06770	COG0545	Peptidyl-prolyl cis-trans isomerase
DR996_RS06780	COG0203	ribosomal protein L17
DR996_RS06785	COG0202	RNA polymerase activity
DR996_RS06795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DR996_RS06800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DR996_RS06805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DR996_RS06810	COG0201	protein transport
DR996_RS06820	COG1841	ribosomal large subunit assembly
DR996_RS06840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DR996_RS06850	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DR996_RS06885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DR996_RS06890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DR996_RS06905	COG0088	Forms part of the polypeptide exit tunnel
DR996_RS06920	COG0254	rRNA binding
DR996_RS06925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DR996_RS06930	COG1609	Transcriptional regulator
DR996_RS06950	COG1575	Belongs to the MenA family. Type 1 subfamily
DR996_RS06955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DR996_RS06965	COG1494	fructose-1,6-bisphosphatase
DR996_RS06990	COG0149	triose-phosphate isomerase activity
DR996_RS07025	COG1216	Glycosyl transferase, family 2
DR996_RS07040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DR996_RS07045	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DR996_RS07065	COG1215	transferase activity, transferring glycosyl groups
DR996_RS07070	COG1216	Glycosyl transferase, family 2
DR996_RS07070	COG1442	glycosyl transferase family 8
DR996_RS07085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DR996_RS07095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DR996_RS07100	COG1215	transferase activity, transferring glycosyl groups
DR996_RS07105	COG2755	lipolytic protein G-D-S-L family
DR996_RS07105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DR996_RS07150	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DR996_RS07190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR996_RS07200	COG1560	Kdo2-lipid A biosynthetic process
DR996_RS07210	COG0438	transferase activity, transferring glycosyl groups
DR996_RS07215	COG1519	Transferase
DR996_RS07220	COG1442	glycosyl transferase family 8
DR996_RS07220	COG1216	Glycosyl transferase, family 2
DR996_RS07225	COG3955	Domain of unknown function (DUF1919)
DR996_RS07235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DR996_RS07265	COG3642	lipopolysaccharide core region biosynthetic process
DR996_RS07270	COG0859	PFAM glycosyl transferase family 9
DR996_RS07275	COG0463	Glycosyl transferase, family 2
DR996_RS07295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DR996_RS07330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DR996_RS07340	COG1560	Kdo2-lipid A biosynthetic process
DR996_RS07350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DR996_RS07355	COG1561	YicC-like family, N-terminal region
DR996_RS07360	COG3710	Transcriptional regulator
DR996_RS07385	COG4608	Belongs to the ABC transporter superfamily
DR996_RS07390	COG0444	Belongs to the ABC transporter superfamily
DR996_RS07395	COG0747	negative chemotaxis
DR996_RS07400	COG4239	(ABC) transporter, permease
DR996_RS07405	COG4174	ABC transporter (Permease)
DR996_RS07425	COG0811	peptide transport
DR996_RS07430	COG0848	biopolymer transport protein
DR996_RS07445	COG0194	GDP metabolic process
DR996_RS07450	COG1758	RNA polymerase activity
DR996_RS07455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DR996_RS07460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR996_RS07465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DR996_RS07470	COG0823	Involved in the tonB-independent uptake of proteins
DR996_RS07470	COG4946	Tricorn protease homolog
DR996_RS07470	COG1506	peptidase
DR996_RS07475	COG2233	PERMEase
DR996_RS07485	COG0745	RESPONSE REGULATOR receiver
DR996_RS07490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_RS07500	COG2183	response to ionizing radiation
DR996_RS07515	COG1040	competence protein
DR996_RS07525	COG0494	nUDIX hydrolase
DR996_RS07530	COG1218	3'(2'),5'-bisphosphate nucleotidase
DR996_RS07540	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DR996_RS07545	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DR996_RS07550	COG3156	type II secretion system protein K
DR996_RS07555	COG4795	General secretion pathway protein
DR996_RS07560	COG2165	general secretion pathway protein
DR996_RS07565	COG2165	general secretion pathway protein
DR996_RS07570	COG2165	general secretion pathway protein
DR996_RS07575	COG1459	type II secretion system
DR996_RS07580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_RS07590	COG3031	protein transport across the cell outer membrane
DR996_RS07595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DR996_RS07615	COG0456	acetyltransferase
DR996_RS07620	COG1490	D-aminoacyl-tRNA deacylase activity
DR996_RS07645	COG0174	glutamine synthetase
DR996_RS07655	COG3852	Histidine kinase
DR996_RS07660	COG2204	response regulator
DR996_RS07670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DR996_RS07700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DR996_RS07705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR996_RS07705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR996_RS07720	COG0084	hydrolase, TatD family'
DR996_RS07725	COG0805	protein transport
DR996_RS07730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DR996_RS07745	COG3165	ubiquinone biosynthetic process from chorismate
DR996_RS07755	COG1322	Protein conserved in bacteria
DR996_RS07855	COG4584	PFAM Integrase catalytic
DR996_RS07860	COG1484	DNA-dependent DNA replication
DR996_RS07875	COG2081	HI0933 family
DR996_RS07910	COG1528	Iron-storage protein
DR996_RS07915	COG0589	response to stress
DR996_RS07935	COG5002	protein histidine kinase activity
DR996_RS07935	COG5001	Diguanylate cyclase
DR996_RS07940	COG1522	sequence-specific DNA binding
DR996_RS07950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DR996_RS07960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_RS08005	COG3501	Rhs element vgr protein
DR996_RS08040	COG0800	Aldolase
DR996_RS08045	COG2610	gluconate transmembrane transporter activity
DR996_RS08050	COG3265	gluconokinase activity
DR996_RS08055	COG0129	dihydroxy-acid dehydratase activity
DR996_RS08065	COG2076	Multidrug Resistance protein
DR996_RS08070	COG0583	DNA-binding transcription factor activity
DR996_RS08075	COG1609	Transcriptional regulator
DR996_RS08110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_RS08125	COG4172	Belongs to the ABC transporter superfamily
DR996_RS08130	COG0546	phosphoglycolate phosphatase activity
DR996_RS08155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_RS08160	COG3344	reverse transcriptase
DR996_RS08165	COG0402	S-adenosylhomocysteine deaminase activity
DR996_RS08295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DR996_RS08300	COG0732	type I restriction modification DNA specificity domain
DR996_RS08315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DR996_RS08355	COG1309	transcriptional regulator
DR996_RS08360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS08365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_RS08370	COG2960	long-chain fatty acid transporting porin activity
DR996_RS08375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DR996_RS08380	COG0583	DNA-binding transcription factor activity
DR996_RS08420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DR996_RS08445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DR996_RS08450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DR996_RS08455	COG0551	DNA topoisomerase type I activity
DR996_RS08465	COG0758	DNA mediated transformation
DR996_RS08475	COG0242	peptide deformylase activity
DR996_RS08485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DR996_RS08485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DR996_RS08490	COG0569	domain protein
DR996_RS08495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR996_RS08505	COG1272	protein, Hemolysin III
DR996_RS08510	COG4326	sporulation control protein
DR996_RS08520	COG3084	Protein conserved in bacteria
DR996_RS08530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DR996_RS08535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_RS08540	COG0204	Acyl-transferase
DR996_RS08610	COG4974	Belongs to the 'phage' integrase family
DR996_RS08615	COG0606	chelatase, subunit chli
DR996_RS08625	COG3978	acetolactate synthase activity
DR996_RS08630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DR996_RS08635	COG0129	dihydroxy-acid dehydratase activity
DR996_RS08645	COG3706	GGDEF domain
DR996_RS08650	COG0583	DNA-binding transcription factor activity
DR996_RS08655	COG2814	Major facilitator Superfamily
DR996_RS08660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_RS08665	COG0765	amino acid transport
DR996_RS08675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DR996_RS08685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DR996_RS08715	COG3312	ion transport
DR996_RS08720	COG1475	DNA binding
DR996_RS08725	COG1192	Involved in chromosome partitioning
DR996_RS08740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DR996_RS08770	COG1126	abc transporter atp-binding protein
DR996_RS08790	COG0592	DNA-directed DNA polymerase activity
DR996_RS08800	COG0187	DNA topoisomerase II activity
DR996_RS08805	COG0071	Belongs to the small heat shock protein (HSP20) family
DR996_RS08810	COG3977	Valine--pyruvate aminotransferase
DR996_RS08815	COG0366	Alpha amylase catalytic
DR996_RS08830	COG2119	membrane
DR996_RS08840	COG0425	Belongs to the sulfur carrier protein TusA family
DR996_RS08855	COG0604	alcohol dehydrogenase
DR996_RS08860	COG0183	Belongs to the thiolase family
DR996_RS08870	COG1739	Uncharacterized protein family UPF0029
DR996_RS08875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR996_RS08925	COG2132	Multicopper oxidase
DR996_RS08945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DR996_RS08950	COG2104	thiamine diphosphate biosynthetic process
DR996_RS08965	COG0006	proline dipeptidase activity
DR996_RS08965	COG0006	proline dipeptidase activity
DR996_RS08975	COG2814	Major facilitator Superfamily
DR996_RS08995	COG3220	belongs to the UPF0276 family
DR996_RS09005	COG0210	DNA helicase
DR996_RS09010	COG0405	Gamma-glutamyltransferase
DR996_RS09015	COG1280	lysine exporter protein (LysE YggA)
DR996_RS09025	COG2962	Rard protein
DR996_RS09030	COG0514	ATP-dependent DNA helicase (RecQ)
DR996_RS09040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DR996_RS09060	COG3118	belongs to the thioredoxin family
DR996_RS09075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DR996_RS09080	COG0633	Ferredoxin
DR996_RS09125	COG2959	enzyme of heme biosynthesis
DR996_RS09130	COG1587	Uroporphyrinogen-III synthase
DR996_RS09140	COG3072	Adenylate cyclase
DR996_RS09155	COG0019	diaminopimelate decarboxylase activity
DR996_RS09175	COG1011	Hydrolase
DR996_RS09180	COG3287	FIST C domain
DR996_RS09180	COG2199	diguanylate cyclase activity
DR996_RS09180	COG2200	EAL domain
DR996_RS09200	COG0561	phosphatase activity
DR996_RS09205	COG2267	carboxylic ester hydrolase activity
DR996_RS09210	COG1280	lysine exporter protein (LysE YggA)
DR996_RS09220	COG3941	tape measure
DR996_RS09235	COG4397	Mu-like prophage major head subunit gpT
DR996_RS09265	COG0488	(ABC) transporter
DR996_RS09305	COG0640	Transcriptional regulator
DR996_RS09310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DR996_RS09355	COG2095	MarC family integral membrane protein
DR996_RS09365	COG0742	ribosomal rna small subunit methyltransferase
DR996_RS09375	COG2884	Cell division ATP-binding protein ftsE
DR996_RS09380	COG2177	Part of the ABC transporter FtsEX involved in
DR996_RS09395	COG0705	Rhomboid family
DR996_RS09400	COG1580	Controls the rotational direction of flagella during chemotaxis
DR996_RS09405	COG3161	chorismate lyase activity
DR996_RS09415	COG2937	Belongs to the GPAT DAPAT family
DR996_RS09430	COG0534	Mate efflux family protein
DR996_RS09435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_RS09535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DR996_RS09545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DR996_RS09590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_RS09610	COG4974	Belongs to the 'phage' integrase family
DR996_RS09625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DR996_RS09630	COG0250	Participates in transcription elongation, termination and antitermination
DR996_RS09635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DR996_RS09645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DR996_RS09650	COG0222	ribosome binding
DR996_RS09665	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
DR996_RS09670	COG2816	NAD+ diphosphatase activity
DR996_RS09680	COG1573	uracil-dna glycosylase
DR996_RS09690	COG3068	Protein conserved in bacteria
DR996_RS09695	COG1253	flavin adenine dinucleotide binding
DR996_RS09710	COG0151	Belongs to the GarS family
DR996_RS09720	COG0789	Transcriptional regulator
DR996_RS09725	COG3710	Transcriptional regulator
DR996_RS09730	COG0531	amino acid
DR996_RS09735	COG1982	Orn Lys Arg decarboxylase major
DR996_RS09780	COG3300	MHYT domain
DR996_RS09780	COG5001	Diguanylate cyclase
DR996_RS09785	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DR996_RS09790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DR996_RS09800	COG0439	Biotin carboxylase
DR996_RS09805	COG0511	ligase activity, forming carbon-carbon bonds
DR996_RS09810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DR996_RS09815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DR996_RS09830	COG2814	Major facilitator Superfamily
DR996_RS09835	COG2205	protein histidine kinase activity
DR996_RS09835	COG2198	Histidine kinase
DR996_RS09835	COG0784	Response regulator, receiver
DR996_RS09855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR996_RS09865	COG2095	MarC family integral membrane protein
DR996_RS09875	COG4232	protein-disulfide reductase activity
DR996_RS09880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DR996_RS09885	COG1027	Aspartate ammonia-lyase
DR996_RS09890	COG3030	protein affecting phage T7 exclusion by the F plasmid
DR996_RS09895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DR996_RS09905	COG2205	protein histidine kinase activity
DR996_RS09910	COG0745	RESPONSE REGULATOR receiver
DR996_RS09915	COG3678	ATP-independent chaperone mediated protein folding
DR996_RS09920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DR996_RS09930	COG0534	Mate efflux family protein
DR996_RS09955	COG1509	lysine 2,3-aminomutase activity
DR996_RS09960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DR996_RS09985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DR996_RS09990	COG1053	succinate dehydrogenase
DR996_RS10015	COG4942	peptidase
DR996_RS10020	COG1045	serine acetyltransferase
DR996_RS10030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DR996_RS10035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DR996_RS10040	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DR996_RS10055	COG0471	metal ion transport
DR996_RS10060	COG3344	reverse transcriptase
DR996_RS10075	COG1162	GTPase activity
DR996_RS10080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DR996_RS10155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DR996_RS10160	COG0802	atpase or kinase
DR996_RS10170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DR996_RS10185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DR996_RS10190	COG0330	HflC and HflK could
DR996_RS10195	COG0330	HflC and HflK could
DR996_RS10200	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DR996_RS10205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DR996_RS10210	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DR996_RS10215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR996_RS10215	COG1017	nitric oxide dioxygenase activity
DR996_RS10225	COG0557	exoribonuclease II activity
DR996_RS10230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR996_RS10235	COG0546	phosphoglycolate phosphatase activity
DR996_RS10255	COG0512	Glutamine amidotransferase of anthranilate synthase
DR996_RS10260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DR996_RS10280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR996_RS10285	COG3954	Phosphoribulokinase
DR996_RS10295	COG0429	hydrolase of the alpha beta-hydrolase fold
DR996_RS10305	COG0488	(ABC) transporter
DR996_RS10310	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_RS10325	COG1047	Peptidyl-prolyl cis-trans
DR996_RS10330	COG1446	asparaginase
DR996_RS10345	COG0545	Peptidyl-prolyl cis-trans isomerase
DR996_RS10350	COG2964	Protein conserved in bacteria
DR996_RS10355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DR996_RS10360	COG2923	Belongs to the DsrF TusC family
DR996_RS10365	COG2168	tRNA wobble position uridine thiolation
DR996_RS10380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR996_RS10390	COG2906	2 iron, 2 sulfur cluster binding
DR996_RS10400	COG0281	malic enzyme
DR996_RS10410	COG0626	cystathionine gamma-synthase activity
DR996_RS10415	COG0527	aspartate kinase activity
DR996_RS10415	COG0460	homoserine dehydrogenase
DR996_RS10420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DR996_RS10430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DR996_RS10440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DR996_RS10455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DR996_RS10455	COG0165	Argininosuccinate lyase
DR996_RS10465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_RS10470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DR996_RS10470	COG0678	peroxiredoxin activity
DR996_RS10480	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DR996_RS10525	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DR996_RS10530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DR996_RS10540	COG2965	DNA replication, synthesis of RNA primer
DR996_RS10560	COG0305	Participates in initiation and elongation during chromosome replication
DR996_RS10565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DR996_RS10575	COG0432	Pfam Uncharacterised protein family UPF0047
DR996_RS10590	COG0735	belongs to the Fur family
DR996_RS10595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DR996_RS10615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DR996_RS10685	COG1410	methionine synthase
DR996_RS10685	COG0646	methionine synthase
DR996_RS10690	COG0527	aspartate kinase activity
DR996_RS10695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DR996_RS10705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DR996_RS10720	COG0629	single-stranded DNA binding
DR996_RS10725	COG2199	diguanylate cyclase activity
DR996_RS10725	COG2200	EAL domain
DR996_RS10750	COG3409	Peptidoglycan-binding domain 1 protein
DR996_RS10750	COG3267	Type II secretory pathway component ExeA
DR996_RS10760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_RS10765	COG1459	type II secretion system
DR996_RS10810	COG1077	Cell shape determining protein MreB Mrl
DR996_RS10815	COG1792	Involved in formation and maintenance of cell shape
DR996_RS10820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DR996_RS10825	COG0424	maF-like protein
DR996_RS10830	COG1530	ribonuclease E activity
DR996_RS10835	COG3164	Protein of unknown function
DR996_RS10840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DR996_RS10845	COG0312	modulator of DNA gyrase
DR996_RS10850	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DR996_RS10875	COG3028	Belongs to the UPF0307 family
DR996_RS10880	COG0312	modulator of DNA gyrase
DR996_RS10885	COG2239	Acts as a magnesium transporter
DR996_RS10890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS10900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS10905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DR996_RS10915	COG1137	ATPase activity
DR996_RS10920	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DR996_RS10930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DR996_RS10930	COG0517	IMP dehydrogenase activity
DR996_RS10940	COG1127	ABC transporter
DR996_RS10945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DR996_RS10950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DR996_RS10955	COG2854	intermembrane phospholipid transfer
DR996_RS10965	COG5007	Belongs to the BolA IbaG family
DR996_RS10975	COG0204	Acyl-transferase
DR996_RS10980	COG0251	oxidation-reduction process
DR996_RS11015	COG0456	acetyltransferase
DR996_RS11025	COG0525	valine-tRNA ligase activity
DR996_RS11030	COG2927	DNA polymerase III (CHI subunit)
DR996_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS11160	COG0726	polysaccharide deacetylase
DR996_RS11165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DR996_RS11175	COG1447	Phosphotransferase system cellobiose-specific component IIA
DR996_RS11330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DR996_RS11335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DR996_RS11350	COG0762	integral membrane protein
DR996_RS11355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DR996_RS11360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DR996_RS11375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DR996_RS11380	COG1678	Uncharacterized ACR, COG1678
DR996_RS11385	COG0189	ligase activity
DR996_RS11390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DR996_RS11395	COG2356	endonuclease I
DR996_RS11415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DR996_RS11435	COG0191	fructose-bisphosphate aldolase activity
DR996_RS11440	COG0668	transmembrane transport
DR996_RS11455	COG0583	DNA-binding transcription factor activity
DR996_RS11465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR996_RS11475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DR996_RS11485	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DR996_RS11495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_RS11500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_RS11520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DR996_RS11530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DR996_RS11535	COG1595	DNA-templated transcription, initiation
DR996_RS11550	COG3086	response to oxidative stress
DR996_RS11570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DR996_RS11575	COG1381	Involved in DNA repair and RecF pathway recombination
DR996_RS11580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DR996_RS11600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DR996_RS11605	COG3956	TIGRFAM MazG family protein
DR996_RS11615	COG0148	phosphopyruvate hydratase activity
DR996_RS11625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DR996_RS11655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DR996_RS11665	COG1546	Belongs to the CinA family
DR996_RS11670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DR996_RS11685	COG0527	aspartate kinase activity
DR996_RS11775	COG3630	sodium ion export across plasma membrane
DR996_RS11780	COG5016	pyruvate
DR996_RS11780	COG0511	ligase activity, forming carbon-carbon bonds
DR996_RS11785	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DR996_RS11795	COG1238	metal cluster binding
DR996_RS11800	COG0612	Peptidase, M16
DR996_RS11820	COG4536	flavin adenine dinucleotide binding
DR996_RS11825	COG4137	Cytochrome C assembly protein
DR996_RS11830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DR996_RS11835	COG0228	four-way junction DNA binding
DR996_RS11850	COG0335	large ribosomal subunit rRNA binding
DR996_RS11855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DR996_RS11860	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DR996_RS11865	COG0237	dephospho-CoA kinase activity
DR996_RS11875	COG1459	type II secretion system
DR996_RS11880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_RS11885	COG4969	Belongs to the N-Me-Phe pilin family
DR996_RS11890	COG0157	Belongs to the NadC ModD family
DR996_RS11900	COG2186	Transcriptional regulator
DR996_RS11905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DR996_RS11910	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR996_RS11915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_RS11935	COG0288	reversible hydration of carbon dioxide
DR996_RS11940	COG0659	secondary active sulfate transmembrane transporter activity
DR996_RS11945	COG1131	(ABC) transporter
DR996_RS11950	COG0842	Transport permease protein
DR996_RS11955	COG1560	Kdo2-lipid A biosynthetic process
DR996_RS11970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DR996_RS11980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR996_RS11995	COG1643	Atp-dependent helicase
DR996_RS12000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR996_RS12005	COG1752	Esterase of the alpha-beta hydrolase superfamily
DR996_RS12010	COG1049	propionate catabolic process, 2-methylcitrate cycle
DR996_RS12025	COG0004	ammonium transporteR
DR996_RS12030	COG1840	ABC-type Fe3 transport system, periplasmic component
DR996_RS12040	COG3842	ATPase activity
DR996_RS12045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR996_RS12060	COG2971	BadF BadG BcrA BcrD
DR996_RS12070	COG4608	Belongs to the ABC transporter superfamily
DR996_RS12075	COG0444	Belongs to the ABC transporter superfamily
DR996_RS12080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_RS12090	COG0747	negative chemotaxis
DR996_RS12095	COG2205	protein histidine kinase activity
DR996_RS12095	COG0784	Response regulator, receiver
DR996_RS12105	COG0628	permease
DR996_RS12125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_RS12130	COG0739	heme binding
DR996_RS12135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DR996_RS12145	COG2027	D-alanyl-D-alanine carboxypeptidase
DR996_RS12150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DR996_RS12155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_RS12160	COG1534	Rna-binding protein
DR996_RS12170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DR996_RS12175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DR996_RS12185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DR996_RS12205	COG0195	Participates in both transcription termination and antitermination
DR996_RS12225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DR996_RS12245	COG0534	Mate efflux family protein
DR996_RS12250	COG0826	peptidase U32
DR996_RS12255	COG0826	peptidase U32
DR996_RS12265	COG3154	lipid carrier protein
DR996_RS12270	COG3153	acetyltransferase
DR996_RS12290	COG3706	GGDEF domain
DR996_RS12335	COG3344	reverse transcriptase
DR996_RS12405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DR996_RS12425	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DR996_RS12555	COG2204	response regulator
DR996_RS12560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_RS12575	COG0681	Belongs to the peptidase S26 family
DR996_RS12615	COG0629	single-stranded DNA binding
DR996_RS12765	COG0084	hydrolase, TatD family'
DR996_RS12770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_RS12780	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DR996_RS12790	COG0813	purine-nucleoside phosphorylase activity
DR996_RS12800	COG0560	Phosphoserine phosphatase
DR996_RS12810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DR996_RS12815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR996_RS12820	COG0583	DNA-binding transcription factor activity
DR996_RS12855	COG1022	Amp-dependent synthetase and ligase
DR996_RS12860	COG0741	lytic transglycosylase activity
DR996_RS12945	COG0583	DNA-binding transcription factor activity
DR996_RS12950	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DR996_RS12950	COG3408	Glycogen debranching enzyme
DR996_RS12960	COG0531	amino acid
DR996_RS12965	COG2731	YhcH YjgK YiaL family protein
DR996_RS12970	COG3250	beta-galactosidase activity
DR996_RS12975	COG1609	Transcriptional regulator
DR996_RS12980	COG0768	penicillin binding
DR996_RS12985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR996_RS12990	COG1085	galactose-1-phosphate uridylyltransferase
DR996_RS13000	COG2017	converts alpha-aldose to the beta-anomer
DR996_RS13005	COG1609	Transcriptional regulator
DR996_RS13010	COG1263	PTS System
DR996_RS13010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS13020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR996_RS13040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DR996_RS13055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_RS13075	COG1757	Na H antiporter
DR996_RS13095	COG2376	Dihydroxyacetone kinase
DR996_RS13100	COG1461	Dihydroxyacetone kinase
DR996_RS13110	COG3284	Transcriptional regulator
DR996_RS13115	COG3960	tartronate-semialdehyde synthase activity
DR996_RS13120	COG3622	Belongs to the hyi family
DR996_RS13125	COG2084	Dehydrogenase
DR996_RS13130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DR996_RS13135	COG1349	DNA-binding transcription factor activity
DR996_RS13145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DR996_RS13150	COG2271	Major facilitator Superfamily
DR996_RS13155	COG0584	glycerophosphoryl diester phosphodiesterase
DR996_RS13160	COG2171	N-acyltransferase activity
DR996_RS13175	COG3141	response to X-ray
DR996_RS13190	COG3083	sulfuric ester hydrolase activity
DR996_RS13195	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DR996_RS13200	COG1074	ATP-dependent DNA helicase activity
DR996_RS13205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_RS13220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DR996_RS13220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DR996_RS13230	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DR996_RS13235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DR996_RS13240	COG2166	iron-sulfur cluster assembly
DR996_RS13245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DR996_RS13250	COG0693	protein deglycase activity
DR996_RS13255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DR996_RS13275	COG1595	DNA-templated transcription, initiation
DR996_RS13305	COG0271	Belongs to the BolA IbaG family
DR996_RS13330	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DR996_RS13340	COG1477	protein flavinylation
DR996_RS13355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DR996_RS13360	COG0514	ATP-dependent DNA helicase (RecQ)
DR996_RS13365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_RS13380	COG0733	neurotransmitter:sodium symporter activity
DR996_RS13405	COG1720	tRNA m6t6A37 methyltransferase activity
DR996_RS13420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DR996_RS13455	COG3098	single-species biofilm formation
DR996_RS13460	COG0564	pseudouridine synthase activity
DR996_RS13475	COG0024	Methionine aminopeptidase
DR996_RS13500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DR996_RS13505	COG0575	Belongs to the CDS family
DR996_RS13515	COG0750	zinc metalloprotease
DR996_RS13525	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DR996_RS13530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DR996_RS13555	COG0587	DNA-directed DNA polymerase activity
DR996_RS13575	COG0347	Belongs to the P(II) protein family
DR996_RS13590	COG0741	lytic transglycosylase activity
DR996_RS13590	COG1388	LysM domain
DR996_RS13600	COG2226	methyltransferase
DR996_RS13610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DR996_RS13635	COG1960	acyl-CoA dehydrogenase activity
DR996_RS13640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DR996_RS13645	COG0121	glutamine amidotransferase
DR996_RS13650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DR996_RS13655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DR996_RS13660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DR996_RS13665	COG2233	PERMEase
DR996_RS13685	COG1393	Belongs to the ArsC family
DR996_RS13690	COG4783	chaperone-mediated protein folding
DR996_RS13705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DR996_RS13780	COG1917	Cupin 2, conserved barrel domain protein
DR996_RS13790	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS13800	COG0517	IMP dehydrogenase activity
DR996_RS13800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DR996_RS13820	COG1904	glucuronate isomerase
DR996_RS13830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DR996_RS13860	COG2716	regulation of RNA biosynthetic process
DR996_RS13865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DR996_RS13890	COG1393	Belongs to the ArsC family
DR996_RS13915	COG2837	iron assimilation
DR996_RS13920	COG2169	Transcriptional regulator
DR996_RS13925	COG1486	melibiose metabolic process
DR996_RS13930	COG2211	Major facilitator Superfamily
DR996_RS13940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_RS13945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_RS13950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_RS13955	COG1334	flagellar protein FlaG
DR996_RS13960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DR996_RS13970	COG1516	flagellar protein fliS
DR996_RS13980	COG4191	Histidine kinase
DR996_RS13990	COG1677	Flagellar hook-basal body complex protein FliE
DR996_RS14000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DR996_RS14055	COG1987	bacterial-type flagellum assembly
DR996_RS14060	COG1684	flagellar biosynthetic protein fliR
DR996_RS14095	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DR996_RS14100	COG0643	Histidine kinase
DR996_RS14100	COG2198	Histidine kinase
DR996_RS14100	COG0784	Response regulator, receiver
DR996_RS14105	COG2201	protein-glutamate methylesterase activity
DR996_RS14110	COG1192	Involved in chromosome partitioning
DR996_RS14120	COG0835	chemotaxis
DR996_RS14130	COG4133	protoheme IX ABC transporter activity
DR996_RS14135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DR996_RS14140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DR996_RS14155	COG1138	Cytochrome C-type biogenesis protein
DR996_RS14160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DR996_RS14170	COG4235	cytochrome complex assembly
DR996_RS14170	COG3088	subunit of a heme lyase
DR996_RS14175	COG2853	Lipoprotein
DR996_RS14180	COG2067	long-chain fatty acid transport protein
DR996_RS14200	COG0183	Belongs to the thiolase family
DR996_RS14220	COG2062	phosphohistidine phosphatase, SixA
DR996_RS14230	COG2890	protein-(glutamine-N5) methyltransferase activity
DR996_RS14240	COG2860	membrane
DR996_RS14245	COG3101	peptidyl-lysine hydroxylation
DR996_RS14265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DR996_RS14270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR996_RS14275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DR996_RS14295	COG0285	dihydrofolate synthase activity
DR996_RS14300	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DR996_RS14305	COG1286	toxin biosynthetic process
DR996_RS14310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DR996_RS14315	COG0583	DNA-binding transcription factor activity
DR996_RS14320	COG0745	RESPONSE REGULATOR receiver
DR996_RS14325	COG2832	Protein of unknown function (DUF454)
DR996_RS14335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DR996_RS14345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DR996_RS14365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DR996_RS14370	COG0814	amino acid
DR996_RS14375	COG0251	oxidation-reduction process
DR996_RS14385	COG2964	Protein conserved in bacteria
DR996_RS14400	COG2983	Belongs to the UPF0260 family
DR996_RS14405	COG2261	transglycosylase associated protein
DR996_RS14410	COG2985	domain, Protein
DR996_RS14415	COG0076	glutamate decarboxylase activity
DR996_RS14420	COG0668	transmembrane transport
DR996_RS14430	COG0346	lactoylglutathione lyase activity
DR996_RS14440	COG1785	Belongs to the alkaline phosphatase family
DR996_RS14455	COG2226	methyltransferase
DR996_RS14480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DR996_RS14485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR996_RS14495	COG3139	Protein of unknown function (DUF1315)
DR996_RS14500	COG0252	asparaginase activity
DR996_RS14505	COG0616	signal peptide processing
DR996_RS14510	COG0446	pyridine nucleotide-disulphide oxidoreductase
DR996_RS14510	COG1902	pentaerythritol trinitrate reductase activity
DR996_RS14515	COG0778	Nitroreductase
DR996_RS14520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR996_RS14535	COG0123	including yeast histone deacetylase and acetoin utilization protein
DR996_RS14540	COG4269	membrane
DR996_RS14555	COG3083	sulfuric ester hydrolase activity
DR996_RS14580	COG1757	Na H antiporter
DR996_RS14585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DR996_RS14595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR996_RS14600	COG2095	MarC family integral membrane protein
DR996_RS14605	COG1454	alcohol dehydrogenase
DR996_RS14605	COG1012	belongs to the aldehyde dehydrogenase family
DR996_RS14625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DR996_RS14635	COG2056	Na+-H+ antiporter family
DR996_RS14645	COG2885	chlorophyll binding
DR996_RS14655	COG0346	lactoylglutathione lyase activity
DR996_RS14660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DR996_RS14665	COG4660	Part of a membrane complex involved in electron transport
DR996_RS14670	COG4659	FMN binding
DR996_RS14675	COG4658	electron transport chain
DR996_RS14680	COG4656	Part of a membrane complex involved in electron transport
DR996_RS14690	COG4657	Part of a membrane complex involved in electron transport
DR996_RS14695	COG1882	Formate acetyltransferase
DR996_RS14705	COG0556	nucleotide-excision repair
DR996_RS14720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DR996_RS14725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DR996_RS14730	COG0521	Mo-molybdopterin cofactor biosynthetic process
DR996_RS14740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DR996_RS14745	COG0314	molybdopterin synthase activity
DR996_RS14755	COG0601	transmembrane transport
DR996_RS14760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_RS14765	COG0444	Belongs to the ABC transporter superfamily
DR996_RS14775	COG0435	Glutathione S-transferase
DR996_RS14780	COG3174	membrane
DR996_RS14790	COG0857	belongs to the CobB CobQ family
DR996_RS14790	COG0280	phosphate acetyltransferase
DR996_RS14810	COG4120	Belongs to the binding-protein-dependent transport system permease family
DR996_RS14815	COG1122	ATPase activity
DR996_RS14820	COG0366	Alpha amylase catalytic
DR996_RS14825	COG3706	GGDEF domain
DR996_RS14830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DR996_RS14835	COG3012	SEC-C Motif Domain Protein
DR996_RS14835	COG3318	Belongs to the UPF0149 family
DR996_RS14840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DR996_RS14850	COG2186	Transcriptional regulator
DR996_RS14890	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DR996_RS14895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DR996_RS14900	COG0659	secondary active sulfate transmembrane transporter activity
DR996_RS14910	COG1530	ribonuclease E activity
DR996_RS14915	COG0564	pseudouridine synthase activity
DR996_RS14920	COG0424	maF-like protein
DR996_RS14925	COG1399	metal-binding, possibly nucleic acid-binding protein
DR996_RS14940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DR996_RS14970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DR996_RS14985	COG0084	hydrolase, TatD family'
DR996_RS14990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS14990	COG1263	PTS System
DR996_RS15005	COG0733	neurotransmitter:sodium symporter activity
DR996_RS15020	COG4667	esterase of the alpha-beta hydrolase superfamily
DR996_RS15030	COG1940	carbohydrate kinase activity
DR996_RS15035	COG0835	chemotaxis
DR996_RS15035	COG0784	Response regulator, receiver
DR996_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS15060	COG0616	signal peptide processing
DR996_RS15070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DR996_RS15075	COG0539	negative regulation of cytoplasmic translation
DR996_RS15085	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DR996_RS15090	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DR996_RS15100	COG4166	transmembrane transport
DR996_RS15160	COG3119	arylsulfatase activity
DR996_RS15165	COG1309	transcriptional regulator
DR996_RS15170	COG3009	Protein conserved in bacteria
DR996_RS15175	COG3008	intermembrane lipid transfer
DR996_RS15175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DR996_RS15180	COG2995	paraquat-inducible protein a
DR996_RS15190	COG3258	Cytochrome c
DR996_RS15195	COG2863	cytochrome
DR996_RS15225	COG3250	beta-galactosidase activity
DR996_RS15235	COG4580	involved in the transport of maltose and maltodextrins
DR996_RS15245	COG2211	Major facilitator Superfamily
DR996_RS15250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_RS15265	COG4232	protein-disulfide reductase activity
DR996_RS15270	COG3118	belongs to the thioredoxin family
DR996_RS15290	COG3153	acetyltransferase
DR996_RS15330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS15340	COG0577	efflux transmembrane transporter activity
DR996_RS15340	COG1136	(ABC) transporter
DR996_RS15345	COG1136	(ABC) transporter
DR996_RS15345	COG0577	efflux transmembrane transporter activity
DR996_RS15350	COG0577	efflux transmembrane transporter activity
DR996_RS15350	COG1136	(ABC) transporter
DR996_RS15355	COG2176	DNA-directed DNA polymerase activity
DR996_RS15370	COG0583	DNA-binding transcription factor activity
DR996_RS15380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DR996_RS15440	COG3850	Histidine kinase
DR996_RS15440	COG5002	protein histidine kinase activity
DR996_RS15445	COG0745	RESPONSE REGULATOR receiver
DR996_RS15450	COG0463	Glycosyl transferase, family 2
DR996_RS15455	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DR996_RS15465	COG0840	transmembrane signaling receptor activity
DR996_RS15470	COG2964	Protein conserved in bacteria
DR996_RS15485	COG0446	pyridine nucleotide-disulphide oxidoreductase
DR996_RS15515	COG1032	radical SAM domain protein
DR996_RS15520	COG3706	GGDEF domain
DR996_RS15520	COG2203	Gaf domain
DR996_RS15520	COG4251	negative regulation of phosphorylation
DR996_RS15520	COG5001	Diguanylate cyclase
DR996_RS15550	COG2350	Protein conserved in bacteria
DR996_RS15585	COG0159	tryptophan synthase activity
DR996_RS15595	COG0134	indole-3-glycerol-phosphate synthase activity
DR996_RS15595	COG0135	phosphoribosylanthranilate isomerase activity
DR996_RS15605	COG0512	Glutamine amidotransferase of anthranilate synthase
DR996_RS15610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR996_RS15620	COG0613	PHP domain protein
DR996_RS15625	COG0009	L-threonylcarbamoyladenylate synthase
DR996_RS15635	COG1187	pseudouridine synthase activity
DR996_RS15655	COG0417	DNA replication proofreading
DR996_RS15660	COG2197	response regulator
DR996_RS15665	COG0322	excinuclease ABC activity
DR996_RS15705	COG0019	diaminopimelate decarboxylase activity
DR996_RS15730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR996_RS15735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR996_RS15740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR996_RS15760	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DR996_RS15770	COG0437	4 iron, 4 sulfur cluster binding
DR996_RS15775	COG3301	Polysulphide reductase, NrfD
DR996_RS15780	COG1138	Cytochrome C-type biogenesis protein
DR996_RS15790	COG4235	cytochrome complex assembly
DR996_RS15790	COG3088	subunit of a heme lyase
DR996_RS15800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DR996_RS15825	COG2989	Protein conserved in bacteria
DR996_RS15830	COG3108	Peptidase M15
DR996_RS15835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DR996_RS15850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DR996_RS15875	COG1846	Transcriptional regulator
DR996_RS15880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_RS15885	COG0840	transmembrane signaling receptor activity
DR996_RS15905	COG1448	Aminotransferase
DR996_RS15910	COG2770	Histidine kinase
DR996_RS15910	COG3437	response regulator, receiver
DR996_RS15915	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR996_RS15925	COG1609	Transcriptional regulator
DR996_RS15940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR996_RS15955	COG0017	Asparaginyl-tRNA synthetase
DR996_RS15965	COG0720	synthase
DR996_RS15970	COG2197	response regulator
DR996_RS15985	COG5001	Diguanylate cyclase
DR996_RS15985	COG3300	MHYT domain
DR996_RS15990	COG1760	l-serine dehydratase
DR996_RS15995	COG0814	amino acid
DR996_RS16010	COG0784	Response regulator, receiver
DR996_RS16010	COG2205	protein histidine kinase activity
DR996_RS16015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR996_RS16030	COG3106	COG3106 Predicted ATPase
DR996_RS16045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR996_RS16210	COG0515	serine threonine protein kinase
DR996_RS16210	COG2815	serine threonine protein kinase
DR996_RS16300	COG0582	viral genome integration into host DNA
DR996_RS16480	COG1335	isochorismatase
DR996_RS16685	COG1683	Conserved Protein
DR996_RS16805	COG1733	regulation of RNA biosynthetic process
DR996_RS16815	COG3340	Belongs to the peptidase S51 family
DR996_RS16825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR996_RS16850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DR996_RS16855	COG1609	Transcriptional regulator
DR996_RS16865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DR996_RS16880	COG0596	Alpha beta hydrolase
DR996_RS16895	COG0456	acetyltransferase
DR996_RS16900	COG0471	metal ion transport
DR996_RS16905	COG4191	Histidine kinase
DR996_RS16905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_RS16915	COG3300	MHYT domain
DR996_RS16915	COG5001	Diguanylate cyclase
DR996_RS16925	COG1280	lysine exporter protein (LysE YggA)
DR996_RS16930	COG1328	CTP reductase activity
DR996_RS16935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DR996_RS16945	COG0861	Integral membrane protein TerC family
DR996_RS16955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_RS16965	COG3706	GGDEF domain
DR996_RS16980	COG0814	amino acid
DR996_RS17000	COG1132	(ABC) transporter
DR996_RS17005	COG1132	(ABC) transporter
DR996_RS17025	COG0583	DNA-binding transcription factor activity
DR996_RS17035	COG0673	inositol 2-dehydrogenase activity
DR996_RS17050	COG0443	Heat shock 70 kDa protein
DR996_RS17055	COG0443	Heat shock 70 kDa protein
DR996_RS17065	COG3706	GGDEF domain
DR996_RS17090	COG3227	Zinc metalloprotease (Elastase)
DR996_RS17110	COG3842	ATPase activity
DR996_RS17115	COG3459	Glycosyltransferase 36 associated
DR996_RS17135	COG0395	ABC-type sugar transport system, permease component
DR996_RS17150	COG0243	molybdopterin cofactor binding
DR996_RS17155	COG0437	4 iron, 4 sulfur cluster binding
DR996_RS17160	COG3302	dmso reductase anchor subunit
DR996_RS17175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DR996_RS17180	COG1643	Atp-dependent helicase
DR996_RS17205	COG3063	Type IV pilus biogenesis stability protein PilW
DR996_RS17245	COG0531	amino acid
DR996_RS17255	COG1280	lysine exporter protein (LysE YggA)
DR996_RS17260	COG0583	DNA-binding transcription factor activity
DR996_RS17265	COG0702	epimerase
DR996_RS17270	COG0583	DNA-binding transcription factor activity
DR996_RS17275	COG1560	Kdo2-lipid A biosynthetic process
DR996_RS17290	COG1846	Transcriptional regulator
DR996_RS17305	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DR996_RS17310	COG1280	lysine exporter protein (LysE YggA)
DR996_RS17340	COG1115	amino acid carrier protein
DR996_RS17395	COG0583	DNA-binding transcription factor activity
DR996_RS17400	COG1368	sulfuric ester hydrolase activity
DR996_RS17405	COG0215	cysteine-tRNA ligase activity
DR996_RS17410	COG0534	Mate efflux family protein
DR996_RS17415	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DR996_RS17425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_RS17430	COG0456	acetyltransferase
DR996_RS17435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DR996_RS17440	COG0662	Cupin 2, conserved barrel domain protein
DR996_RS17445	COG0527	aspartate kinase activity
DR996_RS17460	COG0583	DNA-binding transcription factor activity
DR996_RS17465	COG1858	cytochrome C peroxidase
DR996_RS17475	COG2022	thiamine diphosphate biosynthetic process
DR996_RS17475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR996_RS17485	COG2814	Major facilitator Superfamily
DR996_RS17490	COG1404	Belongs to the peptidase S8 family
DR996_RS17495	COG0583	DNA-binding transcription factor activity
DR996_RS17500	COG0702	epimerase
DR996_RS17515	COG2207	Transcriptional regulator
DR996_RS17520	COG0697	spore germination
DR996_RS17525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DR996_RS17540	COG0583	DNA-binding transcription factor activity
DR996_RS17545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR996_RS17550	COG0653	protein targeting
DR996_RS17565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS17580	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR996_RS17585	COG3290	protein histidine kinase activity
DR996_RS17590	COG4565	transcriptional regulatory protein
DR996_RS17595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DR996_RS17600	COG0363	glucosamine-6-phosphate deaminase activity
DR996_RS17605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DR996_RS17640	COG3284	Transcriptional regulator
DR996_RS17645	COG1012	belongs to the aldehyde dehydrogenase family
DR996_RS17650	COG1902	pentaerythritol trinitrate reductase activity
DR996_RS17660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_RS17665	COG2358	TRAP transporter, solute receptor (TAXI family
DR996_RS17670	COG0840	transmembrane signaling receptor activity
DR996_RS17675	COG0730	response to heat
DR996_RS17700	COG0456	acetyltransferase
DR996_RS17710	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_RS17715	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_RS17800	COG3209	COG3209 Rhs family protein
DR996_RS17810	COG3501	Rhs element vgr protein
DR996_RS17825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DR996_RS17830	COG0372	Belongs to the citrate synthase family
DR996_RS17840	COG2828	Protein conserved in bacteria
DR996_RS17865	COG0561	phosphatase activity
DR996_RS17870	COG0602	queuosine metabolic process
DR996_RS17880	COG3706	GGDEF domain
DR996_RS17930	COG1254	Belongs to the acylphosphatase family
DR996_RS17935	COG2920	part of a sulfur-relay system
DR996_RS17945	COG0670	Belongs to the BI1 family
DR996_RS17950	COG1126	abc transporter atp-binding protein
DR996_RS17955	COG0765	amino acid transport
DR996_RS17960	COG4597	amino acid ABC transporter
DR996_RS17965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_RS17980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR996_RS18005	COG3008	intermembrane lipid transfer
DR996_RS18010	COG2995	paraquat-inducible protein a
DR996_RS18015	COG1132	(ABC) transporter
DR996_RS18020	COG1956	GAF domain-containing protein
DR996_RS18025	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DR996_RS18030	COG0793	Belongs to the peptidase S41A family
DR996_RS18040	COG0308	aminopeptidase N
DR996_RS18050	COG2902	Dehydrogenase
DR996_RS18095	COG1067	ATP-dependent peptidase activity
DR996_RS18140	COG3278	Belongs to the heme-copper respiratory oxidase family
DR996_RS18155	COG2010	Cytochrome c
DR996_RS18165	COG2217	Heavy metal translocating P-type atpase
DR996_RS18180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR996_RS18185	COG0589	response to stress
DR996_RS18210	COG3842	ATPase activity
DR996_RS18220	COG1177	transmembrane transport
DR996_RS18230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DR996_RS18235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DR996_RS18250	COG0437	4 iron, 4 sulfur cluster binding
DR996_RS18255	COG3383	formate dehydrogenase (NAD+) activity
DR996_RS18255	COG0243	molybdopterin cofactor binding
DR996_RS18265	COG3381	protein complex oligomerization
DR996_RS18285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DR996_RS18290	COG0488	(ABC) transporter
DR996_RS18305	COG4191	Histidine kinase
DR996_RS18310	COG2204	response regulator
DR996_RS18320	COG4662	Binding-protein-dependent transport system inner membrane component
DR996_RS18325	COG3842	ATPase activity
DR996_RS18335	COG0303	'Molybdopterin
DR996_RS18350	COG1940	carbohydrate kinase activity
DR996_RS18410	COG0791	NLP P60 protein
DR996_RS18420	COG3706	GGDEF domain
DR996_RS18425	COG2201	protein-glutamate methylesterase activity
DR996_RS18430	COG3001	Fructosamine kinase
DR996_RS18440	COG0307	riboflavin synthase, alpha
DR996_RS18445	COG0534	Mate efflux family protein
DR996_RS18455	COG1793	dna ligase
DR996_RS18465	COG2885	chlorophyll binding
DR996_RS18485	COG2204	response regulator
DR996_RS18495	COG0438	transferase activity, transferring glycosyl groups
DR996_RS18535	COG0297	glycogen (starch) synthase activity
DR996_RS18570	COG0488	(ABC) transporter
DR996_RS18715	COG1022	Amp-dependent synthetase and ligase
DR996_RS18750	COG0583	DNA-binding transcription factor activity
DR996_RS18755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR996_RS18760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DR996_RS18770	COG0560	Phosphoserine phosphatase
DR996_RS18780	COG0813	purine-nucleoside phosphorylase activity
DR996_RS18790	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DR996_RS18800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_RS18805	COG0084	hydrolase, TatD family'
DR996_RS18920	COG2003	Belongs to the UPF0758 family
DR996_RS18945	COG0714	Associated with various cellular activities
DR996_RS18965	COG0629	single-stranded DNA binding
DR996_RS19150	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DR996_RS19170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DR996_RS19240	COG3344	reverse transcriptase
DR996_RS19295	COG3153	acetyltransferase
DR996_RS19300	COG3154	lipid carrier protein
DR996_RS19310	COG0826	peptidase U32
DR996_RS19315	COG0826	peptidase U32
DR996_RS19320	COG0534	Mate efflux family protein
DR996_RS19340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DR996_RS19360	COG0195	Participates in both transcription termination and antitermination
DR996_RS19380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DR996_RS19390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DR996_RS19405	COG1534	Rna-binding protein
DR996_RS19410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_RS19415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DR996_RS19420	COG2027	D-alanyl-D-alanine carboxypeptidase
DR996_RS19460	COG0628	permease
DR996_RS19470	COG2205	protein histidine kinase activity
DR996_RS19470	COG0784	Response regulator, receiver
DR996_RS19475	COG0747	negative chemotaxis
DR996_RS19485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_RS19490	COG0444	Belongs to the ABC transporter superfamily
DR996_RS19495	COG4608	Belongs to the ABC transporter superfamily
DR996_RS19505	COG2971	BadF BadG BcrA BcrD
DR996_RS19520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR996_RS19525	COG3842	ATPase activity
DR996_RS19535	COG1840	ABC-type Fe3 transport system, periplasmic component
DR996_RS19540	COG0004	ammonium transporteR
DR996_RS19555	COG1049	propionate catabolic process, 2-methylcitrate cycle
DR996_RS19560	COG1752	Esterase of the alpha-beta hydrolase superfamily
DR996_RS19565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR996_RS19570	COG1643	Atp-dependent helicase
DR996_RS19585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR996_RS19595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DR996_RS19610	COG1560	Kdo2-lipid A biosynthetic process
DR996_RS19615	COG0842	Transport permease protein
DR996_RS19620	COG1131	(ABC) transporter
DR996_RS19625	COG0659	secondary active sulfate transmembrane transporter activity
DR996_RS19630	COG0288	reversible hydration of carbon dioxide
DR996_RS19650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_RS19655	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR996_RS19660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DR996_RS19665	COG2186	Transcriptional regulator
DR996_RS19675	COG0157	Belongs to the NadC ModD family
DR996_RS19680	COG4969	Belongs to the N-Me-Phe pilin family
DR996_RS19685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_RS19690	COG1459	type II secretion system
DR996_RS19700	COG0237	dephospho-CoA kinase activity
DR996_RS19705	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DR996_RS19710	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DR996_RS19715	COG0335	large ribosomal subunit rRNA binding
DR996_RS19730	COG0228	four-way junction DNA binding
DR996_RS19735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DR996_RS19740	COG4137	Cytochrome C assembly protein
DR996_RS19745	COG4536	flavin adenine dinucleotide binding
DR996_RS19770	COG1238	metal cluster binding
DR996_RS19790	COG3630	sodium ion export across plasma membrane
DR996_RS19880	COG0527	aspartate kinase activity
DR996_RS19895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DR996_RS19900	COG1546	Belongs to the CinA family
DR996_RS19910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DR996_RS19940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DR996_RS19950	COG0148	phosphopyruvate hydratase activity
DR996_RS19960	COG3956	TIGRFAM MazG family protein
DR996_RS19965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DR996_RS19985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DR996_RS19990	COG1381	Involved in DNA repair and RecF pathway recombination
DR996_RS19995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DR996_RS20015	COG3086	response to oxidative stress
DR996_RS20030	COG1595	DNA-templated transcription, initiation
DR996_RS20035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DR996_RS20045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DR996_RS20065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_RS20070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_RS20080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DR996_RS20090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DR996_RS20100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR996_RS20110	COG0583	DNA-binding transcription factor activity
DR996_RS20125	COG0668	transmembrane transport
DR996_RS20130	COG0191	fructose-bisphosphate aldolase activity
DR996_RS20150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DR996_RS20170	COG2356	endonuclease I
DR996_RS20175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DR996_RS20180	COG0189	ligase activity
DR996_RS20185	COG1678	Uncharacterized ACR, COG1678
DR996_RS20190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DR996_RS20205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DR996_RS20210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DR996_RS20215	COG0762	integral membrane protein
DR996_RS20230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DR996_RS20325	COG1012	belongs to the aldehyde dehydrogenase family
DR996_RS20370	COG3437	response regulator, receiver
DR996_RS20390	COG1447	Phosphotransferase system cellobiose-specific component IIA
DR996_RS20460	COG2378	regulation of single-species biofilm formation
DR996_RS20480	COG4974	Belongs to the 'phage' integrase family
DR996_RS20505	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS20515	COG0795	lipopolysaccharide-transporting ATPase activity
DR996_RS20520	COG0795	lipopolysaccharide-transporting ATPase activity
DR996_RS20530	COG2927	DNA polymerase III (CHI subunit)
DR996_RS20535	COG0525	valine-tRNA ligase activity
DR996_RS20595	COG5007	Belongs to the BolA IbaG family
DR996_RS20640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DR996_RS20655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DR996_RS20670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS20685	COG3028	Belongs to the UPF0307 family
DR996_RS20690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DR996_RS20695	COG0564	pseudouridine synthase activity
DR996_RS20710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DR996_RS20715	COG0312	modulator of DNA gyrase
DR996_RS20720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DR996_RS20725	COG3164	Protein of unknown function
DR996_RS20730	COG1530	ribonuclease E activity
DR996_RS20750	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DR996_RS20755	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DR996_RS20770	COG3152	Membrane
DR996_RS20780	COG2199	diguanylate cyclase activity
DR996_RS20790	COG0561	phosphatase activity
DR996_RS20805	COG0564	pseudouridine synthase activity
DR996_RS20810	COG0534	Mate efflux family protein
DR996_RS20815	COG1609	Transcriptional regulator
DR996_RS20820	COG3842	ATPase activity
DR996_RS20825	COG2723	6-phospho-beta-galactosidase activity
DR996_RS20830	COG0395	ABC-type sugar transport system, permease component
DR996_RS20845	COG1609	Transcriptional regulator
DR996_RS20850	COG4580	involved in the transport of maltose and maltodextrins
DR996_RS20855	COG5001	Diguanylate cyclase
DR996_RS20905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DR996_RS20915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DR996_RS20920	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DR996_RS20930	COG2259	Doxx family
DR996_RS20935	COG1741	Belongs to the pirin family
DR996_RS20970	COG3623	hexulose-6-phosphate isomerase
DR996_RS20975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DR996_RS20980	COG0561	phosphatase activity
DR996_RS21030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_RS21035	COG0251	oxidation-reduction process
DR996_RS21055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_RS21065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DR996_RS21070	COG2207	Transcriptional regulator
DR996_RS21080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DR996_RS21125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR996_RS21130	COG2207	Transcriptional regulator
DR996_RS21145	COG0786	glutamate:sodium symporter activity
DR996_RS21150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR996_RS21155	COG1131	(ABC) transporter
DR996_RS21170	COG0786	glutamate:sodium symporter activity
DR996_RS21195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DR996_RS21205	COG3279	Response regulator of the LytR AlgR family
DR996_RS21225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_RS21230	COG3344	reverse transcriptase
DR996_RS21245	COG1444	tRNA N-acetyltransferase activity
DR996_RS21270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DR996_RS21275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS21275	COG1263	PTS System
DR996_RS21280	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DR996_RS21295	COG4166	transmembrane transport
DR996_RS21330	COG2409	Drug exporters of the RND superfamily
DR996_RS21335	COG2197	response regulator
DR996_RS21390	COG0406	alpha-ribazole phosphatase activity
DR996_RS21425	COG4232	protein-disulfide reductase activity
DR996_RS21435	COG1132	(ABC) transporter
DR996_RS21465	COG0800	Aldolase
DR996_RS21470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS21475	COG1904	glucuronate isomerase
DR996_RS21500	COG0800	Aldolase
DR996_RS21505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS21510	COG1904	glucuronate isomerase
DR996_RS21515	COG0246	Mannitol dehydrogenase
DR996_RS21525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DR996_RS21535	COG2186	Transcriptional regulator
DR996_RS21540	COG1312	Catalyzes the dehydration of D-mannonate
DR996_RS21545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR996_RS21555	COG1595	DNA-templated transcription, initiation
DR996_RS21575	COG0513	Belongs to the DEAD box helicase family
DR996_RS21580	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR996_RS21585	COG1757	Na H antiporter
DR996_RS21590	COG1609	Transcriptional regulator
DR996_RS21595	COG2258	MOSC domain
DR996_RS21615	COG1522	sequence-specific DNA binding
DR996_RS21625	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DR996_RS21635	COG0840	transmembrane signaling receptor activity
DR996_RS21640	COG0346	lactoylglutathione lyase activity
DR996_RS21660	COG1349	DNA-binding transcription factor activity
DR996_RS21665	COG2084	Dehydrogenase
DR996_RS21670	COG3395	kinase activity
DR996_RS21675	COG0235	Class ii aldolase
DR996_RS21680	COG3622	Belongs to the hyi family
DR996_RS21685	COG2610	gluconate transmembrane transporter activity
DR996_RS21710	COG3634	alkyl hydroperoxide reductase activity
DR996_RS21720	COG1846	Transcriptional regulator
DR996_RS21725	COG1764	response to oxidative stress
DR996_RS21775	COG1136	(ABC) transporter
DR996_RS21785	COG0583	DNA-binding transcription factor activity
DR996_RS21795	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_RS21805	COG0667	Aldo Keto reductase
DR996_RS21835	COG0840	transmembrane signaling receptor activity
DR996_RS21840	COG0612	Peptidase, M16
DR996_RS21875	COG3121	Chaperone
DR996_RS21890	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DR996_RS21905	COG0732	type I restriction modification DNA specificity domain
DR996_RS21910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DR996_RS22045	COG0402	S-adenosylhomocysteine deaminase activity
DR996_RS22055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_RS22060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_RS22095	COG1760	l-serine dehydratase
DR996_RS22100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS22100	COG1263	PTS System
DR996_RS22120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DR996_RS22150	COG2199	diguanylate cyclase activity
DR996_RS22150	COG2203	Gaf domain
DR996_RS22160	COG4580	involved in the transport of maltose and maltodextrins
DR996_RS22180	COG2356	endonuclease I
DR996_RS22200	COG1982	Orn Lys Arg decarboxylase major
DR996_RS22205	COG0531	amino acid
DR996_RS22230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DR996_RS22235	COG0183	Belongs to the thiolase family
DR996_RS22255	COG2814	Major facilitator Superfamily
DR996_RS22255	COG0477	Major facilitator Superfamily
DR996_RS22265	COG3962	Belongs to the TPP enzyme family
DR996_RS22270	COG0673	inositol 2-dehydrogenase activity
DR996_RS22275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS22300	COG0673	inositol 2-dehydrogenase activity
DR996_RS22305	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DR996_RS22310	COG1162	GTPase activity
DR996_RS22345	COG0058	SHG alpha-glucan phosphorylase activity
DR996_RS22350	COG1640	4-alpha-glucanotransferase
DR996_RS22355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DR996_RS22360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR996_RS22365	COG0366	Alpha amylase catalytic
DR996_RS22380	COG3366	ferrous iron transmembrane transporter activity
DR996_RS22385	COG0700	Nucleoside recognition
DR996_RS22390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DR996_RS22395	COG3339	Conserved Protein
DR996_RS22400	COG1301	dicarboxylic acid transport
DR996_RS22430	COG2814	Major facilitator Superfamily
DR996_RS22435	COG0583	DNA-binding transcription factor activity
DR996_RS22455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DR996_RS22475	COG2095	MarC family integral membrane protein
DR996_RS22480	COG4667	esterase of the alpha-beta hydrolase superfamily
DR996_RS22490	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DR996_RS22495	COG0415	Belongs to the DNA photolyase family
DR996_RS22520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR996_RS22545	COG1686	Belongs to the peptidase S11 family
DR996_RS22570	COG0583	DNA-binding transcription factor activity
DR996_RS22575	COG4628	conserved protein (DUF2132)
DR996_RS22585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR996_RS22600	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DR996_RS22605	COG0628	permease
DR996_RS22645	COG2988	succinylglutamate desuccinylase activity
DR996_RS22650	COG0583	DNA-binding transcription factor activity
DR996_RS22675	COG2814	Major facilitator Superfamily
DR996_RS22685	COG0148	phosphopyruvate hydratase activity
DR996_RS22690	COG0454	-acetyltransferase
DR996_RS22700	COG0745	RESPONSE REGULATOR receiver
DR996_RS22705	COG2205	protein histidine kinase activity
DR996_RS22720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DR996_RS22725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DR996_RS22730	COG1882	Formate acetyltransferase
DR996_RS22740	COG2207	Transcriptional regulator
DR996_RS22775	COG1294	oxidase, subunit
DR996_RS22780	COG1271	oxidase subunit
DR996_RS22795	COG3220	belongs to the UPF0276 family
DR996_RS22810	COG0384	phenazine biosynthesis protein PhzF
DR996_RS22815	COG0346	lactoylglutathione lyase activity
DR996_RS22830	COG0488	(ABC) transporter
DR996_RS22835	COG4628	conserved protein (DUF2132)
DR996_RS22840	COG0583	DNA-binding transcription factor activity
DR996_RS22845	COG0431	NADPH-dependent FMN reductase
DR996_RS22850	COG0435	Glutathione S-transferase
DR996_RS22855	COG0488	(ABC) transporter
DR996_RS22870	COG0583	DNA-binding transcription factor activity
DR996_RS22885	COG3226	Transcriptional regulator
DR996_RS22900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DR996_RS22905	COG1280	lysine exporter protein (LysE YggA)
DR996_RS22935	COG3226	Transcriptional regulator
DR996_RS22950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DR996_RS22955	COG1280	lysine exporter protein (LysE YggA)
DR996_RS22985	COG0737	Belongs to the 5'-nucleotidase family
DR996_RS22995	COG3537	Alpha-1,2-mannosidase
DR996_RS23005	COG3537	Alpha-1,2-mannosidase
DR996_RS23010	COG3537	Alpha-1,2-mannosidase
DR996_RS23015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_RS23025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR996_RS23025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR996_RS23030	COG0346	lactoylglutathione lyase activity
DR996_RS23035	COG1349	DNA-binding transcription factor activity
DR996_RS23040	COG1609	Transcriptional regulator
DR996_RS23045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS23045	COG1263	PTS System
DR996_RS23050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR996_RS23075	COG0753	catalase activity
DR996_RS23090	COG1335	isochorismatase
DR996_RS23115	COG3136	membrane protein required for alginate biosynthesis
DR996_RS23140	COG0583	DNA-binding transcription factor activity
DR996_RS23145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DR996_RS23160	COG4175	Glycine betaine
DR996_RS23160	COG3448	diguanylate cyclase activity
DR996_RS23165	COG4176	ABC-type proline glycine betaine transport system permease component
DR996_RS23175	COG1342	Belongs to the UPF0251 family
DR996_RS23215	COG4948	Mandelate Racemase Muconate Lactonizing
DR996_RS23230	COG2188	Transcriptional regulator
DR996_RS23235	COG1263	PTS System
DR996_RS23235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_RS23240	COG1621	beta-fructofuranosidase activity
DR996_RS23285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DR996_RS23295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_RS23305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_RS23355	COG4964	Belongs to the GSP D family
DR996_RS23420	COG0318	PFAM AMP-dependent synthetase and ligase
DR996_RS23430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_RS23460	COG0786	glutamate:sodium symporter activity
DR996_RS23465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DR996_RS23485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS23490	COG0583	DNA-binding transcription factor activity
DR996_RS23540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DR996_RS23545	COG2197	response regulator
DR996_RS23555	COG0574	Belongs to the PEP-utilizing enzyme family
DR996_RS23555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DR996_RS23565	COG0252	asparaginase activity
DR996_RS23585	COG0583	DNA-binding transcription factor activity
DR996_RS23605	COG0583	DNA-binding transcription factor activity
DR996_RS23610	COG3122	Protein conserved in bacteria
DR996_RS23625	COG1902	pentaerythritol trinitrate reductase activity
DR996_RS23635	COG2814	Major facilitator Superfamily
DR996_RS23640	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS23660	COG0583	DNA-binding transcription factor activity
DR996_RS23690	COG2814	Major facilitator Superfamily
DR996_RS23695	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS23715	COG0583	DNA-binding transcription factor activity
DR996_RS23725	COG0513	Belongs to the DEAD box helicase family
DR996_RS23755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR996_RS23760	COG2207	Transcriptional regulator
DR996_RS23760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DR996_RS23765	COG0583	DNA-binding transcription factor activity
DR996_RS23775	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS23790	COG3746	phosphate-selective porin O and P
DR996_RS23815	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS23825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DR996_RS23835	COG0625	glutathione transferase activity
DR996_RS23845	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_RS23850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_RS23855	COG1686	Belongs to the peptidase S11 family
DR996_RS23860	COG3706	GGDEF domain
DR996_RS23870	COG2226	methyltransferase
DR996_RS23900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DR996_RS23910	COG1278	Cold shock
DR996_RS23920	COG1278	Cold shock
DR996_RS23925	COG1741	Belongs to the pirin family
DR996_RS23930	COG4667	esterase of the alpha-beta hydrolase superfamily
DR996_RS23940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DR996_RS23950	COG0523	cobalamin synthesis protein
DR996_RS23990	COG3842	ATPase activity
DR996_RS23995	COG0395	ABC-type sugar transport system, permease component
DR996_RS24025	COG0589	response to stress
DR996_RS24045	COG1720	tRNA m6t6A37 methyltransferase activity
DR996_RS24050	COG0488	(ABC) transporter
DR996_RS24055	COG1505	serine-type exopeptidase activity
DR996_RS24075	COG2067	long-chain fatty acid transport protein
DR996_RS24085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR996_RS24095	COG1858	cytochrome C peroxidase
DR996_RS24110	COG0494	nUDIX hydrolase
DR996_RS24125	COG0456	acetyltransferase
DR996_RS24130	COG0604	alcohol dehydrogenase
DR996_RS24130	COG3321	synthase
DR996_RS24130	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS24170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_RS24190	COG3383	formate dehydrogenase (NAD+) activity
DR996_RS24205	COG0842	Transport permease protein
DR996_RS24210	COG1131	(ABC) transporter
DR996_RS24220	COG0840	transmembrane signaling receptor activity
DR996_RS24235	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DR996_RS24245	COG4145	pantothenate transmembrane transporter activity
DR996_RS24250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS24255	COG0800	Aldolase
DR996_RS24270	COG0251	oxidation-reduction process
DR996_RS24280	COG1881	PFAM PEBP family protein
DR996_RS24295	COG0798	PFAM Bile acid sodium symporter
DR996_RS24310	COG1733	regulation of RNA biosynthetic process
DR996_RS24330	COG4989	oxidoreductase activity
DR996_RS24340	COG1482	cell wall glycoprotein biosynthetic process
DR996_RS24345	COG0383	alpha-mannosidase activity
DR996_RS24350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS24350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_RS24350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_RS24355	COG2188	Transcriptional regulator
DR996_RS24360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS24365	COG2213	PTS system mannitol-specific
DR996_RS24370	COG1063	alcohol dehydrogenase
DR996_RS24380	COG1072	(Pantothenic acid kinase))
DR996_RS24385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DR996_RS24405	COG0814	amino acid
DR996_RS24440	COG0739	heme binding
DR996_RS24445	COG5001	Diguanylate cyclase
DR996_RS24450	COG1120	ATPase activity
DR996_RS24465	COG4774	siderophore transport
DR996_RS24480	COG0583	DNA-binding transcription factor activity
DR996_RS24485	COG2814	Major facilitator Superfamily
DR996_RS24500	COG0697	spore germination
DR996_RS24515	COG0179	Fumarylacetoacetate (FAA) hydrolase
DR996_RS24535	COG1280	lysine exporter protein (LysE YggA)
DR996_RS24545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR996_RS24560	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DR996_RS24565	COG1845	cytochrome c oxidase, subunit III
DR996_RS24585	COG1612	heme a metabolic process
DR996_RS24600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR996_RS24605	COG2814	Major facilitator Superfamily
DR996_RS24610	COG0840	transmembrane signaling receptor activity
DR996_RS24615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DR996_RS24640	COG2897	thiosulfate sulfurtransferase activity
DR996_RS24675	COG1914	H( )-stimulated, divalent metal cation uptake system
DR996_RS24700	COG4989	oxidoreductase activity
DR996_RS24715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DR996_RS24715	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DR996_RS24745	COG0402	S-adenosylhomocysteine deaminase activity
DR996_RS24760	COG3706	GGDEF domain
DR996_RS24795	COG4176	ABC-type proline glycine betaine transport system permease component
DR996_RS24800	COG4175	Glycine betaine
DR996_RS24800	COG0517	IMP dehydrogenase activity
DR996_RS24815	COG0778	Nitroreductase
DR996_RS24825	COG1960	acyl-CoA dehydrogenase activity
DR996_RS24845	COG3284	Transcriptional regulator
DR996_RS24855	COG0330	HflC and HflK could
DR996_RS24910	COG4974	Belongs to the 'phage' integrase family
DR996_RS24940	COG0745	RESPONSE REGULATOR receiver
DR996_RS24960	COG0586	Pfam SNARE associated Golgi protein
DR996_RS24980	COG0494	nUDIX hydrolase
DR996_RS24985	COG1051	belongs to the nudix hydrolase family
DR996_RS24990	COG1794	racemase activity, acting on amino acids and derivatives
DR996_RS24995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DR996_RS25000	COG5001	Diguanylate cyclase
DR996_RS25010	COG1129	ABC transporter
DR996_RS25015	COG1172	Belongs to the binding-protein-dependent transport system permease family
DR996_RS25025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS25030	COG1609	Transcriptional regulator
DR996_RS25040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DR996_RS25055	COG4607	ABC-type enterochelin transport system periplasmic component
DR996_RS25060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_RS25065	COG4605	iron ion homeostasis
DR996_RS25070	COG4604	ABC transporter, ATP-binding protein
DR996_RS25075	COG0789	Transcriptional regulator
DR996_RS25085	COG4206	TonB-dependent receptor
DR996_RS25125	COG2801	Transposase and inactivated derivatives
DR996_RS25130	COG2842	Transposition protein
DR996_RS25255	COG1289	transmembrane transporter activity
DR996_RS25260	COG0210	DNA helicase
DR996_RS25270	COG1879	ABC-type sugar transport system periplasmic component
DR996_RS25275	COG2205	protein histidine kinase activity
DR996_RS25275	COG0784	Response regulator, receiver
DR996_RS25275	COG2198	Histidine kinase
DR996_RS25305	COG3119	arylsulfatase activity
DR996_RS25310	COG3119	arylsulfatase activity
DR996_RS25315	COG3119	arylsulfatase activity
DR996_RS25320	COG3063	Type IV pilus biogenesis stability protein PilW
DR996_RS25325	COG0583	DNA-binding transcription factor activity
DR996_RS25330	COG3119	arylsulfatase activity
DR996_RS25335	COG0641	radical SAM
DR996_RS25340	COG0714	Associated with various cellular activities
DR996_RS25400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DR996_RS25410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DR996_RS25420	COG0583	DNA-binding transcription factor activity
DR996_RS25425	COG1597	lipid kinase activity
DR996_RS25430	COG3111	PFAM Bacterial OB fold (BOF) protein
DR996_RS25450	COG0641	radical SAM
DR996_RS25475	COG0501	Belongs to the peptidase M48B family
DR996_RS25480	COG1704	LemA family
DR996_RS25485	COG3069	C4-dicarboxylate transmembrane transporter activity
DR996_RS25515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DR996_RS25520	COG0739	heme binding
DR996_RS25540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_RS25545	COG3344	reverse transcriptase
DR996_RS25560	COG2204	response regulator
DR996_RS25575	COG3501	Rhs element vgr protein
DR996_RS25600	COG0515	serine threonine protein kinase
DR996_RS25635	COG1522	sequence-specific DNA binding
DR996_RS25715	COG0784	Response regulator, receiver
DR996_RS25715	COG2205	protein histidine kinase activity
DR996_RS25720	COG5001	Diguanylate cyclase
DR996_RS25720	COG3300	MHYT domain
DR996_RS25725	COG2197	response regulator
DR996_RS25730	COG3706	GGDEF domain
DR996_RS25740	COG2197	response regulator
DR996_RS25750	COG0778	Nitroreductase
DR996_RS25755	COG0784	Response regulator, receiver
DR996_RS25755	COG0835	chemotaxis
DR996_RS25785	COG0671	phosphoesterase, PA-phosphatase related
DR996_RS25830	COG2067	long-chain fatty acid transport protein
DR996_RS25835	COG1234	tRNA 3'-trailer cleavage
DR996_RS25850	COG5642	Protein of unknown function (DUF2384)
DR996_RS25860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DR996_RS25860	COG2755	lipolytic protein G-D-S-L family
DR996_RS25870	COG1902	pentaerythritol trinitrate reductase activity
DR996_RS25875	COG0346	lactoylglutathione lyase activity
DR996_RS25915	COG0515	serine threonine protein kinase
DR996_RS25915	COG2815	serine threonine protein kinase
DR996_RS25950	COG0631	protein serine/threonine phosphatase activity
DR996_RS26005	COG3501	Rhs element vgr protein
DR996_RS26035	COG0420	3'-5' exonuclease activity
DR996_RS26040	COG0419	ATPase involved in DNA repair
DR996_RS26050	COG3469	chitinase activity
DR996_RS26080	COG3040	lipid binding
DR996_RS26090	COG2814	Major facilitator Superfamily
DR996_RS26100	COG1288	antiporter activity
DR996_RS26110	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DR996_RS26125	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DR996_RS26135	COG1472	Belongs to the glycosyl hydrolase 3 family
DR996_RS26140	COG0583	DNA-binding transcription factor activity
DR996_RS26145	COG0277	FAD linked oxidase domain protein
DR996_RS26220	COG2199	diguanylate cyclase activity
DR996_RS26230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DR996_RS26240	COG2116	formate transmembrane transporter activity
DR996_RS26260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DR996_RS26280	COG0534	Mate efflux family protein
DR996_RS26285	COG3292	Two component regulator propeller
DR996_RS26285	COG2205	protein histidine kinase activity
DR996_RS26285	COG0745	RESPONSE REGULATOR receiver
DR996_RS26295	COG3118	belongs to the thioredoxin family
DR996_RS26300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DR996_RS26330	COG1566	PFAM secretion protein HlyD family protein
DR996_RS26340	COG0628	permease
DR996_RS26350	COG1482	cell wall glycoprotein biosynthetic process
DR996_RS26355	COG2271	Major facilitator Superfamily
DR996_RS26360	COG3851	Histidine kinase
DR996_RS26365	COG2197	response regulator
DR996_RS26440	COG1328	CTP reductase activity
DR996_RS26445	COG0602	queuosine metabolic process
DR996_RS26450	COG0534	Mate efflux family protein
DR996_RS26475	COG3111	PFAM Bacterial OB fold (BOF) protein
DR996_RS26485	COG0725	ABC transporter, periplasmic molybdate-binding protein
DR996_RS26490	COG4149	molybdate abc transporter
DR996_RS26495	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DR996_RS26505	COG3706	GGDEF domain
DR996_RS26505	COG5001	Diguanylate cyclase
DR996_RS26505	COG4251	negative regulation of phosphorylation
DR996_RS26505	COG2203	Gaf domain
DR996_RS26515	COG3706	GGDEF domain
DR996_RS26530	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DR996_RS26535	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DR996_RS26560	COG3140	Belongs to the UPF0181 family
DR996_RS26570	COG0023	Translation Initiation Factor
DR996_RS26590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR996_RS26590	COG1042	CoA-binding domain protein
DR996_RS26590	COG0045	succinate-CoA ligase (ADP-forming) activity
DR996_RS26595	COG0583	DNA-binding transcription factor activity
DR996_RS26605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR996_RS26610	COG3447	MASE1 domain protein
DR996_RS26610	COG5002	protein histidine kinase activity
DR996_RS26610	COG5001	Diguanylate cyclase
DR996_RS26620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DR996_RS26625	COG1984	allophanate hydrolase subunit 2
DR996_RS26635	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DR996_RS26640	COG4181	ATPase activity
DR996_RS26650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DR996_RS26655	COG5001	Diguanylate cyclase
DR996_RS26655	COG3300	MHYT domain
DR996_RS26665	COG0484	heat shock protein binding
DR996_RS26700	COG2050	protein possibly involved in aromatic compounds catabolism
DR996_RS26720	COG2267	carboxylic ester hydrolase activity
DR996_RS26735	COG0646	methionine synthase
DR996_RS26735	COG1410	methionine synthase
DR996_RS26755	COG0737	Belongs to the 5'-nucleotidase family
DR996_RS26760	COG3593	DNA synthesis involved in DNA repair
DR996_RS26770	COG0583	DNA-binding transcription factor activity
DR996_RS26775	COG2116	formate transmembrane transporter activity
DR996_RS26785	COG3038	cytochrome b561
DR996_RS26800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DR996_RS26805	COG0513	Belongs to the DEAD box helicase family
DR996_RS26810	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
DR996_RS26815	COG0840	transmembrane signaling receptor activity
DR996_RS26820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR996_RS26825	COG0784	Response regulator, receiver
DR996_RS26825	COG3437	response regulator, receiver
DR996_RS26840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_RS26850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DR996_RS26860	COG2207	Transcriptional regulator
DR996_RS26865	COG1979	alcohol dehydrogenase
DR996_RS26875	COG1126	abc transporter atp-binding protein
DR996_RS26880	COG0765	amino acid transport
DR996_RS26885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_RS26890	COG0765	amino acid transport
DR996_RS26895	COG2200	EAL domain
DR996_RS26895	COG2203	Gaf domain
DR996_RS26895	COG2199	diguanylate cyclase activity
DR996_RS26910	COG1609	Transcriptional regulator
DR996_RS26915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS26915	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS26920	COG1105	Belongs to the carbohydrate kinase PfkB family
DR996_RS26925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_RS26925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_RS26925	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DR996_RS26955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS26970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DR996_RS26980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DR996_RS26985	COG0509	glycine decarboxylation via glycine cleavage system
DR996_RS26995	COG0497	DNA recombination
DR996_RS27030	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS27040	COG2814	Major facilitator Superfamily
DR996_RS27080	COG1132	(ABC) transporter
DR996_RS27155	COG0662	Cupin 2, conserved barrel domain protein
DR996_RS27155	COG2207	Transcriptional regulator
DR996_RS27170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_RS27190	COG0523	cobalamin synthesis protein
DR996_RS27205	COG1024	Enoyl-CoA hydratase
DR996_RS27235	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_RS27260	COG0628	permease
DR996_RS27295	COG0739	heme binding
DR996_RS27305	COG0583	DNA-binding transcription factor activity
DR996_RS27315	COG1271	oxidase subunit
DR996_RS27320	COG1294	oxidase, subunit
DR996_RS27325	COG1320	monovalent cation:proton antiporter activity
DR996_RS27330	COG2212	antiporter activity
DR996_RS27345	COG1006	Multisubunit Na H antiporter MnhC subunit
DR996_RS27350	COG2111	Na H antiporter
DR996_RS27350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DR996_RS27360	COG0589	response to stress
DR996_RS27370	COG1414	Transcriptional regulator
DR996_RS27385	COG0814	amino acid
DR996_RS27405	COG1475	DNA binding
DR996_RS27415	COG1902	pentaerythritol trinitrate reductase activity
DR996_RS27435	COG4968	Prepilin-type N-terminal cleavage methylation domain
DR996_RS27440	COG2770	Histidine kinase
DR996_RS27440	COG2205	protein histidine kinase activity
DR996_RS27445	COG0745	RESPONSE REGULATOR receiver
DR996_RS27465	COG2205	protein histidine kinase activity
DR996_RS27465	COG2770	Histidine kinase
DR996_RS27470	COG0745	RESPONSE REGULATOR receiver
DR996_RS27520	COG2146	nitrite reductase [NAD(P)H] activity
DR996_RS27520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DR996_RS27525	COG1116	anion transmembrane transporter activity
DR996_RS27530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DR996_RS27535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DR996_RS27535	COG1116	anion transmembrane transporter activity
DR996_RS27555	COG1648	precorrin-2 dehydrogenase activity
DR996_RS27555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DR996_RS27560	COG0243	molybdopterin cofactor binding
DR996_RS27570	COG5002	protein histidine kinase activity
DR996_RS27570	COG5001	Diguanylate cyclase
DR996_RS27575	COG0814	amino acid
DR996_RS27580	COG3706	GGDEF domain
DR996_RS27605	COG1785	Belongs to the alkaline phosphatase family
DR996_RS27620	COG0745	RESPONSE REGULATOR receiver
DR996_RS27650	COG2847	Copper chaperone PCu(A)C
DR996_RS27655	COG0443	Heat shock 70 kDa protein
DR996_RS27725	COG3976	FMN-binding domain protein
DR996_RS27725	COG0431	NADPH-dependent FMN reductase
DR996_RS27725	COG1053	succinate dehydrogenase
DR996_RS27730	COG3119	arylsulfatase activity
DR996_RS27740	COG0583	DNA-binding transcription factor activity
DR996_RS27750	COG0840	transmembrane signaling receptor activity
DR996_RS27755	COG4160	amino acid transport
DR996_RS27830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_RS27840	COG1012	belongs to the aldehyde dehydrogenase family
DR996_RS27855	COG0446	pyridine nucleotide-disulphide oxidoreductase
DR996_RS27855	COG1902	pentaerythritol trinitrate reductase activity
DR996_RS27865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DR996_RS27870	COG1845	cytochrome c oxidase, subunit III
DR996_RS27875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DR996_RS27880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DR996_RS27885	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS27895	COG1024	Enoyl-CoA hydratase
DR996_RS27900	COG1024	Enoyl-CoA hydratase
DR996_RS27915	COG0183	Belongs to the thiolase family
DR996_RS27925	COG1960	acyl-CoA dehydrogenase activity
DR996_RS27930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DR996_RS27935	COG1024	Enoyl-CoA hydratase
DR996_RS27965	COG3278	Belongs to the heme-copper respiratory oxidase family
DR996_RS27980	COG3344	reverse transcriptase
DR996_RS27985	COG1752	Esterase of the alpha-beta hydrolase superfamily
DR996_RS27995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DR996_RS28000	COG3344	reverse transcriptase
DR996_RS28020	COG3550	peptidyl-serine autophosphorylation
DR996_RS28030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DR996_RS28060	COG1119	ATPase activity
DR996_RS28065	COG5001	Diguanylate cyclase
DR996_RS28065	COG3300	MHYT domain
DR996_RS28085	COG0513	Belongs to the DEAD box helicase family
DR996_RS28095	COG0523	cobalamin synthesis protein
DR996_RS28125	COG3530	Putative quorum-sensing-regulated virulence factor
DR996_RS28155	COG3186	Phenylalanine-4-hydroxylase
DR996_RS28160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DR996_RS28165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR996_RS28190	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DR996_RS28210	COG2133	pyrroloquinoline quinone binding
DR996_RS28215	COG1619	proteins homologs of microcin C7 resistance protein MccF
DR996_RS28225	COG0783	Belongs to the Dps family
DR996_RS28230	COG0840	transmembrane signaling receptor activity
DR996_RS28255	COG0784	Response regulator, receiver
DR996_RS28255	COG2205	protein histidine kinase activity
DR996_RS28260	COG1538	Outer membrane efflux protein
DR996_RS28290	COG1136	(ABC) transporter
DR996_RS28290	COG0577	efflux transmembrane transporter activity
DR996_RS28295	COG1136	(ABC) transporter
DR996_RS28295	COG0577	efflux transmembrane transporter activity
DR996_RS28310	COG2199	diguanylate cyclase activity
DR996_RS28320	COG3036	rescue of stalled ribosome
DR996_RS28325	COG1278	Cold shock
DR996_RS28355	COG0545	Peptidyl-prolyl cis-trans isomerase
DR996_RS28360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR996_RS28370	COG0840	transmembrane signaling receptor activity
DR996_RS28390	COG2195	Cleaves the N-terminal amino acid of tripeptides
DR996_RS28405	COG2197	response regulator
DR996_RS28410	COG3850	Histidine kinase
DR996_RS28415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DR996_RS28435	COG3005	denitrification pathway
DR996_RS28465	COG3005	denitrification pathway
DR996_RS28485	COG0183	Belongs to the thiolase family
DR996_RS28495	COG1280	lysine exporter protein (LysE YggA)
DR996_RS28505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR996_RS28510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR996_RS28585	COG0673	inositol 2-dehydrogenase activity
DR996_RS28625	COG1522	sequence-specific DNA binding
DR996_RS28630	COG0531	amino acid
DR996_RS28640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_RS28660	COG2205	protein histidine kinase activity
DR996_RS28665	COG0745	RESPONSE REGULATOR receiver
DR996_RS28690	COG1566	PFAM secretion protein HlyD family protein
DR996_RS28695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DR996_RS28700	COG2239	Acts as a magnesium transporter
DR996_RS28705	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DR996_RS28710	COG0402	S-adenosylhomocysteine deaminase activity
DR996_RS28725	COG1418	mRNA catabolic process
DR996_RS28750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DR996_RS28770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_RS28785	COG4221	oxidoreductase activity
DR996_RS28795	COG0745	RESPONSE REGULATOR receiver
DR996_RS28800	COG2205	protein histidine kinase activity
DR996_RS28810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DR996_RS28815	COG2194	sulfuric ester hydrolase activity
DR996_RS28835	COG1335	isochorismatase
DR996_RS28855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DR996_RS28860	COG2194	sulfuric ester hydrolase activity
DR996_RS28880	COG1335	isochorismatase
DR996_RS28895	COG2814	Major facilitator Superfamily
DR996_RS28915	COG0583	DNA-binding transcription factor activity
DR996_RS28920	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_RS28935	COG0583	DNA-binding transcription factor activity
DR996_RS29010	COG0583	DNA-binding transcription factor activity
DR996_RS29015	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_RS29030	COG0583	DNA-binding transcription factor activity
DR996_RS29085	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS29085	COG0604	alcohol dehydrogenase
DR996_RS29085	COG3321	synthase
DR996_RS29090	COG0366	Alpha amylase catalytic
DR996_RS29095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR996_RS29100	COG0835	chemotaxis
DR996_RS29100	COG0784	Response regulator, receiver
DR996_RS29115	COG0748	coenzyme F420 binding
DR996_RS29120	COG3721	Heme iron utilization protein
DR996_RS29130	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DR996_RS29135	COG0811	peptide transport
DR996_RS29140	COG0848	biopolymer transport protein
DR996_RS29150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_RS29155	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DR996_RS29195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DR996_RS29205	COG3217	Mosc domain protein beta barrel domain protein
DR996_RS29205	COG3217	Mosc domain protein beta barrel domain protein
DR996_RS29205	COG0633	Ferredoxin
DR996_RS29205	COG0633	Ferredoxin
DR996_RS29210	COG0401	homolog of Blt101
DR996_RS29220	COG2354	Protein conserved in bacteria
DR996_RS29250	COG3833	ABC-type maltose transport systems, permease component
DR996_RS29255	COG1175	transmembrane transport
DR996_RS29265	COG3842	ATPase activity
DR996_RS29340	COG1309	transcriptional regulator
DR996_RS29345	COG2130	NADP-dependent
DR996_RS29355	COG0753	catalase activity
DR996_RS29360	COG2084	Dehydrogenase
DR996_RS29380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_RS29390	COG2207	Transcriptional regulator
DR996_RS29395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_RS29395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_RS29395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_RS29410	COG0583	DNA-binding transcription factor activity
DR996_RS29415	COG1566	PFAM secretion protein HlyD family protein
DR996_RS29450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR996_RS29460	COG1301	dicarboxylic acid transport
DR996_RS29465	COG1252	NADH dehydrogenase
DR996_RS29475	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DR996_RS29480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DR996_RS29550	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS29555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DR996_RS29565	COG0573	inorganic phosphate transmembrane transporter activity
DR996_RS29575	COG4191	Histidine kinase
DR996_RS29580	COG2204	response regulator
DR996_RS29585	COG0110	maltose O-acetyltransferase activity
DR996_RS29625	COG0840	transmembrane signaling receptor activity
DR996_RS29645	COG0714	Associated with various cellular activities
DR996_RS29665	COG2304	oxidoreductase activity
DR996_RS29680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DR996_RS29685	COG0581	inorganic phosphate transmembrane transporter activity
DR996_RS29690	COG0573	inorganic phosphate transmembrane transporter activity
DR996_RS29700	COG0840	transmembrane signaling receptor activity
DR996_RS29720	COG4771	TonB-dependent receptor
DR996_RS29725	COG1770	oligopeptidase
DR996_RS29735	COG0513	Belongs to the DEAD box helicase family
DR996_RS29745	COG1376	ErfK ybiS ycfS ynhG family protein
DR996_RS29745	COG1388	LysM domain
DR996_RS29750	COG0415	Belongs to the DNA photolyase family
DR996_RS29755	COG0789	Transcriptional regulator
DR996_RS29760	COG3272	Protein of unknown function (DUF1722)
DR996_RS29765	COG0813	purine-nucleoside phosphorylase activity
DR996_RS29780	COG3706	GGDEF domain
DR996_RS29795	COG1566	PFAM secretion protein HlyD family protein
DR996_RS29805	COG1122	ATPase activity
DR996_RS29820	COG2731	YhcH YjgK YiaL family protein
DR996_RS29830	COG0640	Transcriptional regulator
DR996_RS29845	COG0348	domain, Protein
DR996_RS29850	COG0437	4 iron, 4 sulfur cluster binding
DR996_RS29855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR996_RS29875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DR996_RS29885	COG1067	ATP-dependent peptidase activity
DR996_RS29895	COG4172	Belongs to the ABC transporter superfamily
DR996_RS29900	COG1505	serine-type exopeptidase activity
DR996_RS29905	COG0583	DNA-binding transcription factor activity
DR996_RS29910	COG1620	l-lactate permease
DR996_RS29915	COG1304	FMN binding
DR996_RS29930	COG0668	transmembrane transport
DR996_RS29950	COG1063	alcohol dehydrogenase
DR996_RS29995	COG0745	RESPONSE REGULATOR receiver
DR996_RS30020	COG0346	lactoylglutathione lyase activity
DR996_RS30075	COG3188	usher protein
DR996_RS30105	COG5002	protein histidine kinase activity
DR996_RS30105	COG5001	Diguanylate cyclase
DR996_RS30165	COG1987	bacterial-type flagellum assembly
DR996_RS30175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DR996_RS30190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_RS30200	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DR996_RS30205	COG1516	flagellar protein fliS
DR996_RS30220	COG1580	Controls the rotational direction of flagella during chemotaxis
DR996_RS30225	COG1191	sigma factor activity
DR996_RS30250	COG2226	methyltransferase
DR996_RS30265	COG3710	Transcriptional regulator
DR996_RS30270	COG1253	flavin adenine dinucleotide binding
DR996_RS30290	COG0583	DNA-binding transcription factor activity
DR996_RS30315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_RS30320	COG4786	Flagellar basal body rod
DR996_RS30320	COG1256	bacterial-type flagellum assembly
DR996_RS30330	COG1706	bacterial-type flagellum-dependent cell motility
DR996_RS30335	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DR996_RS30340	COG4786	Flagellar basal body rod
DR996_RS30345	COG4787	bacterial-type flagellum-dependent cell motility
DR996_RS30350	COG1749	Flagellar hook protein flgE
DR996_RS30355	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DR996_RS30360	COG1558	bacterial-type flagellum-dependent cell motility
DR996_RS30365	COG1815	bacterial-type flagellum-dependent cell motility
DR996_RS30385	COG0741	lytic transglycosylase activity
DR996_RS30385	COG1388	LysM domain
DR996_RS30410	COG1760	l-serine dehydratase
DR996_RS30415	COG3104	oligopeptide transport
DR996_RS30440	COG0583	DNA-binding transcription factor activity
DR996_RS30450	COG2866	Carboxypeptidase
DR996_RS30455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR996_RS30465	COG2990	Protein conserved in bacteria
DR996_RS30500	COG1840	ABC-type Fe3 transport system, periplasmic component
DR996_RS30520	COG1609	Transcriptional regulator
DR996_RS30550	COG3240	lipase activity
DR996_RS30555	COG1737	Transcriptional regulator
DR996_RS30570	COG0698	ribose 5-phosphate isomerase
DR996_RS30575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DR996_RS30580	COG1511	domain protein
DR996_RS30580	COG3264	Mechanosensitive ion channel
DR996_RS30615	COG1011	Hydrolase
DR996_RS30630	COG0439	Biotin carboxylase
DR996_RS30645	COG3842	ATPase activity
DR996_RS30660	COG3706	GGDEF domain
DR996_RS30675	COG3706	GGDEF domain
DR996_RS30695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DR996_RS30700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_RS30715	COG3033	Beta-eliminating lyase
DR996_RS30730	COG0579	oxidoreductase
DR996_RS30745	COG1114	Component of the transport system for branched-chain amino acids
DR996_RS30750	COG3706	GGDEF domain
DR996_RS30790	COG0583	DNA-binding transcription factor activity
DR996_RS30810	COG0189	ligase activity
DR996_RS30815	COG0189	ligase activity
DR996_RS30815	COG4067	protein conserved in archaea
DR996_RS30825	COG1166	arginine decarboxylase activity
DR996_RS30830	COG0010	Belongs to the arginase family
DR996_RS30835	COG2814	Major facilitator Superfamily
DR996_RS30840	COG1770	oligopeptidase
DR996_RS30855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DR996_RS30860	COG1121	(ABC) transporter
DR996_RS30865	COG0803	Belongs to the bacterial solute-binding protein 9 family
DR996_RS30910	COG0848	biopolymer transport protein
DR996_RS30915	COG0811	peptide transport
DR996_RS30920	COG0811	peptide transport
DR996_RS30940	COG0745	RESPONSE REGULATOR receiver
DR996_RS30945	COG0039	L-malate dehydrogenase activity
DR996_RS30950	COG0584	glycerophosphoryl diester phosphodiesterase
DR996_RS30960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DR996_RS31020	COG0312	modulator of DNA gyrase
DR996_RS31025	COG0312	modulator of DNA gyrase
DR996_RS31030	COG0351	phosphomethylpyrimidine kinase
DR996_RS31035	COG1116	anion transmembrane transporter activity
DR996_RS31040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DR996_RS31045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DR996_RS31050	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DR996_RS31065	COG0671	phosphoesterase, PA-phosphatase related
DR996_RS31075	COG5002	protein histidine kinase activity
DR996_RS31080	COG0243	molybdopterin cofactor binding
DR996_RS31085	COG3005	denitrification pathway
DR996_RS31095	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_RS31115	COG0456	acetyltransferase
DR996_RS31160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR996_RS31165	COG1929	Belongs to the glycerate kinase type-1 family
DR996_RS31170	COG3835	regulator
DR996_RS31180	COG1228	amidohydrolase
DR996_RS31205	COG0546	phosphoglycolate phosphatase activity
DR996_RS31215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_RS31250	COG0583	DNA-binding transcription factor activity
DR996_RS31280	COG3408	Glycogen debranching enzyme
DR996_RS31280	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DR996_RS31300	COG2814	Major facilitator Superfamily
DR996_RS31315	COG2358	TRAP transporter, solute receptor (TAXI family
DR996_RS31320	COG3047	cAMP biosynthetic process
DR996_RS31325	COG1357	PFAM Pentapeptide repeats (8 copies)
DR996_RS31340	COG2076	Multidrug Resistance protein
DR996_RS31385	COG0583	DNA-binding transcription factor activity
DR996_RS31400	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DR996_RS31405	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DR996_RS31420	COG3152	Membrane
DR996_RS31455	COG2067	long-chain fatty acid transport protein
DR996_RS31475	COG3549	Plasmid maintenance system killer
DR996_RS31480	COG3093	addiction module antidote protein HigA
DR996_RS31645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_RS31740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR996_RS31865	COG2885	chlorophyll binding
DR996_RS32030	COG2003	Belongs to the UPF0758 family
DR996_RS32155	COG2003	Belongs to the UPF0758 family
DR996_RS32225	COG0640	Transcriptional regulator
DR996_RS32245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR996_RS32415	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DR996_RS32505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR996_RS32575	COG0714	Associated with various cellular activities
DR996_RS32625	COG0681	Belongs to the peptidase S26 family
DR996_RS32640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_RS32730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR996_RS32815	COG1192	Involved in chromosome partitioning
DR996_RS32855	COG1357	PFAM Pentapeptide repeats (8 copies)
DR996_RS32930	COG3209	COG3209 Rhs family protein
DR996_RS33095	COG3423	Transcriptional regulator
DR996_RS33255	COG0419	ATPase involved in DNA repair
DR996_RS33280	COG1192	Involved in chromosome partitioning
DR996_RS33325	COG5268	conjugation
DR996_RS33330	COG3451	type IV secretory pathway VirB4
DR996_RS33340	COG4962	Type ii secretion system protein e
DR996_RS33355	COG3504	Conjugal transfer protein
DR996_RS33390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB