locus-tag	class	description
APZ19_RS00015	COG0592	DNA-directed DNA polymerase activity
APZ19_RS00025	COG0187	DNA topoisomerase II activity
APZ19_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
APZ19_RS00035	COG3977	Valine--pyruvate aminotransferase
APZ19_RS00055	COG4964	Belongs to the GSP D family
APZ19_RS00120	COG0366	Alpha amylase catalytic
APZ19_RS00135	COG2119	membrane
APZ19_RS00145	COG0425	Belongs to the sulfur carrier protein TusA family
APZ19_RS00160	COG0604	alcohol dehydrogenase
APZ19_RS00165	COG0183	Belongs to the thiolase family
APZ19_RS00175	COG1739	Uncharacterized protein family UPF0029
APZ19_RS00180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APZ19_RS00225	COG2132	Multicopper oxidase
APZ19_RS00245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APZ19_RS00250	COG2104	thiamine diphosphate biosynthetic process
APZ19_RS00265	COG0006	proline dipeptidase activity
APZ19_RS00265	COG0006	proline dipeptidase activity
APZ19_RS00275	COG2814	Major facilitator Superfamily
APZ19_RS00295	COG3220	belongs to the UPF0276 family
APZ19_RS00305	COG0210	DNA helicase
APZ19_RS00315	COG0405	Gamma-glutamyltransferase
APZ19_RS00320	COG1280	lysine exporter protein (LysE YggA)
APZ19_RS00330	COG2962	Rard protein
APZ19_RS00335	COG0514	ATP-dependent DNA helicase (RecQ)
APZ19_RS00345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APZ19_RS00365	COG3118	belongs to the thioredoxin family
APZ19_RS00380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APZ19_RS00385	COG0633	Ferredoxin
APZ19_RS00435	COG2959	enzyme of heme biosynthesis
APZ19_RS00440	COG1587	Uroporphyrinogen-III synthase
APZ19_RS00450	COG3072	Adenylate cyclase
APZ19_RS00465	COG0019	diaminopimelate decarboxylase activity
APZ19_RS00485	COG1011	Hydrolase
APZ19_RS00490	COG2200	EAL domain
APZ19_RS00490	COG2199	diguanylate cyclase activity
APZ19_RS00490	COG3287	FIST C domain
APZ19_RS00495	COG3148	PFAM DTW domain containing protein
APZ19_RS00510	COG0561	phosphatase activity
APZ19_RS00515	COG2267	carboxylic ester hydrolase activity
APZ19_RS00520	COG1280	lysine exporter protein (LysE YggA)
APZ19_RS00525	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
APZ19_RS00530	COG0640	Transcriptional regulator
APZ19_RS00535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APZ19_RS00585	COG2095	MarC family integral membrane protein
APZ19_RS00595	COG0742	ribosomal rna small subunit methyltransferase
APZ19_RS00600	COG0552	protein localization to endoplasmic reticulum
APZ19_RS00600	COG0552	protein localization to endoplasmic reticulum
APZ19_RS00605	COG2884	Cell division ATP-binding protein ftsE
APZ19_RS00610	COG2177	Part of the ABC transporter FtsEX involved in
APZ19_RS00625	COG0705	Rhomboid family
APZ19_RS00630	COG1580	Controls the rotational direction of flagella during chemotaxis
APZ19_RS00635	COG3161	chorismate lyase activity
APZ19_RS00645	COG2937	Belongs to the GPAT DAPAT family
APZ19_RS00660	COG0534	Mate efflux family protein
APZ19_RS00665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APZ19_RS00765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APZ19_RS00775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APZ19_RS00825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APZ19_RS00830	COG0250	Participates in transcription elongation, termination and antitermination
APZ19_RS00835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APZ19_RS00845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APZ19_RS00850	COG0222	ribosome binding
APZ19_RS00865	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
APZ19_RS00870	COG2816	NAD+ diphosphatase activity
APZ19_RS00880	COG1573	uracil-dna glycosylase
APZ19_RS00890	COG3068	Protein conserved in bacteria
APZ19_RS00895	COG1253	flavin adenine dinucleotide binding
APZ19_RS00910	COG0151	Belongs to the GarS family
APZ19_RS00920	COG0789	Transcriptional regulator
APZ19_RS00925	COG3710	Transcriptional regulator
APZ19_RS00930	COG0531	amino acid
APZ19_RS00935	COG1982	Orn Lys Arg decarboxylase major
APZ19_RS00980	COG2199	diguanylate cyclase activity
APZ19_RS00985	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APZ19_RS00990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APZ19_RS01005	COG0439	Biotin carboxylase
APZ19_RS01010	COG0511	ligase activity, forming carbon-carbon bonds
APZ19_RS01015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APZ19_RS01020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APZ19_RS01035	COG2814	Major facilitator Superfamily
APZ19_RS01040	COG2205	protein histidine kinase activity
APZ19_RS01040	COG2198	Histidine kinase
APZ19_RS01040	COG0784	Response regulator, receiver
APZ19_RS01060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APZ19_RS01070	COG2095	MarC family integral membrane protein
APZ19_RS01080	COG4232	protein-disulfide reductase activity
APZ19_RS01085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APZ19_RS01090	COG1027	Aspartate ammonia-lyase
APZ19_RS01095	COG3030	protein affecting phage T7 exclusion by the F plasmid
APZ19_RS01100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APZ19_RS01110	COG2205	protein histidine kinase activity
APZ19_RS01115	COG0745	RESPONSE REGULATOR receiver
APZ19_RS01120	COG3678	ATP-independent chaperone mediated protein folding
APZ19_RS01125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APZ19_RS01135	COG0534	Mate efflux family protein
APZ19_RS01160	COG1509	lysine 2,3-aminomutase activity
APZ19_RS01165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APZ19_RS01190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APZ19_RS01195	COG1053	succinate dehydrogenase
APZ19_RS01220	COG4942	peptidase
APZ19_RS01225	COG1045	serine acetyltransferase
APZ19_RS01235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APZ19_RS01240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APZ19_RS01245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APZ19_RS01255	COG0840	transmembrane signaling receptor activity
APZ19_RS01260	COG0471	metal ion transport
APZ19_RS01275	COG1162	GTPase activity
APZ19_RS01280	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APZ19_RS01355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APZ19_RS01360	COG0802	atpase or kinase
APZ19_RS01365	COG0860	N-Acetylmuramoyl-L-alanine amidase
APZ19_RS01370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APZ19_RS01385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APZ19_RS01390	COG0330	HflC and HflK could
APZ19_RS01395	COG0330	HflC and HflK could
APZ19_RS01400	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
APZ19_RS01405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APZ19_RS01415	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APZ19_RS01420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APZ19_RS01420	COG1017	nitric oxide dioxygenase activity
APZ19_RS01430	COG0557	exoribonuclease II activity
APZ19_RS01435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APZ19_RS01440	COG0546	phosphoglycolate phosphatase activity
APZ19_RS01455	COG0512	Glutamine amidotransferase of anthranilate synthase
APZ19_RS01460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APZ19_RS01480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APZ19_RS01485	COG3954	Phosphoribulokinase
APZ19_RS01495	COG0429	hydrolase of the alpha beta-hydrolase fold
APZ19_RS01505	COG0488	(ABC) transporter
APZ19_RS01515	COG2249	NAD(P)H dehydrogenase (quinone) activity
APZ19_RS01530	COG1047	Peptidyl-prolyl cis-trans
APZ19_RS01540	COG1446	asparaginase
APZ19_RS01555	COG0545	Peptidyl-prolyl cis-trans isomerase
APZ19_RS01560	COG2964	Protein conserved in bacteria
APZ19_RS01565	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APZ19_RS01570	COG2923	Belongs to the DsrF TusC family
APZ19_RS01575	COG2168	tRNA wobble position uridine thiolation
APZ19_RS01590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APZ19_RS01600	COG2906	2 iron, 2 sulfur cluster binding
APZ19_RS01610	COG0281	malic enzyme
APZ19_RS01620	COG0626	cystathionine gamma-synthase activity
APZ19_RS01625	COG0460	homoserine dehydrogenase
APZ19_RS01625	COG0527	aspartate kinase activity
APZ19_RS01630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APZ19_RS01640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APZ19_RS01650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APZ19_RS01665	COG0165	Argininosuccinate lyase
APZ19_RS01665	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APZ19_RS01680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APZ19_RS01685	COG0678	peroxiredoxin activity
APZ19_RS01685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APZ19_RS01695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APZ19_RS01740	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APZ19_RS01745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APZ19_RS01755	COG2965	DNA replication, synthesis of RNA primer
APZ19_RS01775	COG0305	Participates in initiation and elongation during chromosome replication
APZ19_RS01780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APZ19_RS01790	COG0432	Pfam Uncharacterised protein family UPF0047
APZ19_RS01805	COG0735	belongs to the Fur family
APZ19_RS01810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APZ19_RS01830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APZ19_RS01895	COG0646	methionine synthase
APZ19_RS01895	COG1410	methionine synthase
APZ19_RS01900	COG0527	aspartate kinase activity
APZ19_RS01905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APZ19_RS01915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APZ19_RS01930	COG0629	single-stranded DNA binding
APZ19_RS01935	COG2200	EAL domain
APZ19_RS01935	COG2199	diguanylate cyclase activity
APZ19_RS01960	COG3409	Peptidoglycan-binding domain 1 protein
APZ19_RS01960	COG3267	Type II secretory pathway component ExeA
APZ19_RS01970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ19_RS01975	COG1459	type II secretion system
APZ19_RS01985	COG2165	general secretion pathway protein
APZ19_RS02020	COG1077	Cell shape determining protein MreB Mrl
APZ19_RS02025	COG1792	Involved in formation and maintenance of cell shape
APZ19_RS02030	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APZ19_RS02035	COG0424	maF-like protein
APZ19_RS02045	COG3164	Protein of unknown function
APZ19_RS02050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APZ19_RS02055	COG0312	modulator of DNA gyrase
APZ19_RS02060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APZ19_RS02075	COG0564	pseudouridine synthase activity
APZ19_RS02080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APZ19_RS02085	COG3028	Belongs to the UPF0307 family
APZ19_RS02090	COG0312	modulator of DNA gyrase
APZ19_RS02095	COG2239	Acts as a magnesium transporter
APZ19_RS02100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS02110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS02115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APZ19_RS02125	COG1137	ATPase activity
APZ19_RS02130	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APZ19_RS02140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APZ19_RS02140	COG0517	IMP dehydrogenase activity
APZ19_RS02150	COG1127	ABC transporter
APZ19_RS02155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APZ19_RS02160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APZ19_RS02165	COG2854	intermembrane phospholipid transfer
APZ19_RS02175	COG5007	Belongs to the BolA IbaG family
APZ19_RS02185	COG0204	Acyl-transferase
APZ19_RS02190	COG0251	oxidation-reduction process
APZ19_RS02240	COG0525	valine-tRNA ligase activity
APZ19_RS02245	COG2927	DNA polymerase III (CHI subunit)
APZ19_RS02255	COG0795	lipopolysaccharide-transporting ATPase activity
APZ19_RS02260	COG0795	lipopolysaccharide-transporting ATPase activity
APZ19_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS02280	COG0726	polysaccharide deacetylase
APZ19_RS02285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APZ19_RS02295	COG1447	Phosphotransferase system cellobiose-specific component IIA
APZ19_RS02300	COG1486	melibiose metabolic process
APZ19_RS02310	COG1609	Transcriptional regulator
APZ19_RS02315	COG3437	response regulator, receiver
APZ19_RS02370	COG1012	belongs to the aldehyde dehydrogenase family
APZ19_RS02470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APZ19_RS02475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APZ19_RS02490	COG0762	integral membrane protein
APZ19_RS02495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APZ19_RS02500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APZ19_RS02515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APZ19_RS02520	COG1678	Uncharacterized ACR, COG1678
APZ19_RS02525	COG0189	ligase activity
APZ19_RS02530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APZ19_RS02535	COG2356	endonuclease I
APZ19_RS02555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APZ19_RS02575	COG0191	fructose-bisphosphate aldolase activity
APZ19_RS02580	COG0668	transmembrane transport
APZ19_RS02595	COG0583	DNA-binding transcription factor activity
APZ19_RS02605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APZ19_RS02615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APZ19_RS02625	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APZ19_RS02640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APZ19_RS02645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APZ19_RS02665	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APZ19_RS02675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APZ19_RS02685	COG1595	DNA-templated transcription, initiation
APZ19_RS02700	COG3086	response to oxidative stress
APZ19_RS02720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APZ19_RS02725	COG1381	Involved in DNA repair and RecF pathway recombination
APZ19_RS02730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APZ19_RS02750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APZ19_RS02755	COG3956	TIGRFAM MazG family protein
APZ19_RS02765	COG0148	phosphopyruvate hydratase activity
APZ19_RS02775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APZ19_RS02805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APZ19_RS02815	COG1546	Belongs to the CinA family
APZ19_RS02820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APZ19_RS02835	COG0527	aspartate kinase activity
APZ19_RS02910	COG3630	sodium ion export across plasma membrane
APZ19_RS02915	COG5016	pyruvate
APZ19_RS02915	COG0511	ligase activity, forming carbon-carbon bonds
APZ19_RS02920	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APZ19_RS02930	COG1238	metal cluster binding
APZ19_RS02935	COG0612	Peptidase, M16
APZ19_RS02955	COG4536	flavin adenine dinucleotide binding
APZ19_RS02960	COG4137	Cytochrome C assembly protein
APZ19_RS02965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APZ19_RS02970	COG0228	four-way junction DNA binding
APZ19_RS02985	COG0335	large ribosomal subunit rRNA binding
APZ19_RS02990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APZ19_RS02995	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
APZ19_RS03000	COG0237	dephospho-CoA kinase activity
APZ19_RS03010	COG1459	type II secretion system
APZ19_RS03015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ19_RS03035	COG2186	Transcriptional regulator
APZ19_RS03040	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APZ19_RS03045	COG0508	dehydrogenase complex catalyzes the overall conversion of
APZ19_RS03050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APZ19_RS03065	COG0288	reversible hydration of carbon dioxide
APZ19_RS03070	COG0659	secondary active sulfate transmembrane transporter activity
APZ19_RS03075	COG1131	(ABC) transporter
APZ19_RS03080	COG0842	Transport permease protein
APZ19_RS03085	COG1560	Kdo2-lipid A biosynthetic process
APZ19_RS03100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APZ19_RS03110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APZ19_RS03125	COG1643	Atp-dependent helicase
APZ19_RS03130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APZ19_RS03135	COG1752	Esterase of the alpha-beta hydrolase superfamily
APZ19_RS03140	COG1049	propionate catabolic process, 2-methylcitrate cycle
APZ19_RS03155	COG0004	ammonium transporteR
APZ19_RS03160	COG1840	ABC-type Fe3 transport system, periplasmic component
APZ19_RS03170	COG3842	ATPase activity
APZ19_RS03175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APZ19_RS03190	COG2971	BadF BadG BcrA BcrD
APZ19_RS03200	COG4608	Belongs to the ABC transporter superfamily
APZ19_RS03205	COG0444	Belongs to the ABC transporter superfamily
APZ19_RS03210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APZ19_RS03220	COG0747	negative chemotaxis
APZ19_RS03225	COG0784	Response regulator, receiver
APZ19_RS03225	COG2205	protein histidine kinase activity
APZ19_RS03235	COG0628	permease
APZ19_RS03255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ19_RS03260	COG0739	heme binding
APZ19_RS03265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APZ19_RS03275	COG2027	D-alanyl-D-alanine carboxypeptidase
APZ19_RS03280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APZ19_RS03285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ19_RS03290	COG1534	Rna-binding protein
APZ19_RS03300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APZ19_RS03305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APZ19_RS03315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APZ19_RS03335	COG0195	Participates in both transcription termination and antitermination
APZ19_RS03355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APZ19_RS03375	COG0534	Mate efflux family protein
APZ19_RS03380	COG0826	peptidase U32
APZ19_RS03385	COG0826	peptidase U32
APZ19_RS03395	COG3154	lipid carrier protein
APZ19_RS03400	COG3153	acetyltransferase
APZ19_RS03420	COG3706	GGDEF domain
APZ19_RS03430	COG0084	hydrolase, TatD family'
APZ19_RS03435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APZ19_RS03445	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
APZ19_RS03455	COG0813	purine-nucleoside phosphorylase activity
APZ19_RS03465	COG0560	Phosphoserine phosphatase
APZ19_RS03475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APZ19_RS03480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APZ19_RS03485	COG0583	DNA-binding transcription factor activity
APZ19_RS03520	COG1022	Amp-dependent synthetase and ligase
APZ19_RS03525	COG0741	lytic transglycosylase activity
APZ19_RS03550	COG4964	Belongs to the GSP D family
APZ19_RS03610	COG0583	DNA-binding transcription factor activity
APZ19_RS03615	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
APZ19_RS03615	COG3408	Glycogen debranching enzyme
APZ19_RS03625	COG0531	amino acid
APZ19_RS03630	COG2731	YhcH YjgK YiaL family protein
APZ19_RS03635	COG3250	beta-galactosidase activity
APZ19_RS03640	COG1609	Transcriptional regulator
APZ19_RS03645	COG0768	penicillin binding
APZ19_RS03650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APZ19_RS03655	COG1085	galactose-1-phosphate uridylyltransferase
APZ19_RS03665	COG2017	converts alpha-aldose to the beta-anomer
APZ19_RS03670	COG1609	Transcriptional regulator
APZ19_RS03675	COG1263	PTS System
APZ19_RS03675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS03685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APZ19_RS03705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APZ19_RS03710	COG1349	DNA-binding transcription factor activity
APZ19_RS03720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APZ19_RS03730	COG2271	Major facilitator Superfamily
APZ19_RS03735	COG0584	glycerophosphoryl diester phosphodiesterase
APZ19_RS03750	COG2171	N-acyltransferase activity
APZ19_RS03765	COG3141	response to X-ray
APZ19_RS03785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APZ19_RS03790	COG1074	ATP-dependent DNA helicase activity
APZ19_RS03795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APZ19_RS03810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APZ19_RS03810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APZ19_RS03820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APZ19_RS03825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APZ19_RS03830	COG2166	iron-sulfur cluster assembly
APZ19_RS03835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APZ19_RS03840	COG0693	protein deglycase activity
APZ19_RS03845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APZ19_RS03850	COG3248	Nucleoside-binding outer membrane protein
APZ19_RS03870	COG1595	DNA-templated transcription, initiation
APZ19_RS03900	COG0271	Belongs to the BolA IbaG family
APZ19_RS03925	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APZ19_RS03935	COG1477	protein flavinylation
APZ19_RS03950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APZ19_RS03955	COG0514	ATP-dependent DNA helicase (RecQ)
APZ19_RS03960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ19_RS03975	COG0733	neurotransmitter:sodium symporter activity
APZ19_RS04000	COG1720	tRNA m6t6A37 methyltransferase activity
APZ19_RS04015	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
APZ19_RS04050	COG3098	single-species biofilm formation
APZ19_RS04055	COG0564	pseudouridine synthase activity
APZ19_RS04070	COG0024	Methionine aminopeptidase
APZ19_RS04095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APZ19_RS04100	COG0575	Belongs to the CDS family
APZ19_RS04110	COG0750	zinc metalloprotease
APZ19_RS04120	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
APZ19_RS04125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APZ19_RS04150	COG0587	DNA-directed DNA polymerase activity
APZ19_RS04170	COG0347	Belongs to the P(II) protein family
APZ19_RS04185	COG0741	lytic transglycosylase activity
APZ19_RS04185	COG1388	LysM domain
APZ19_RS04195	COG2226	methyltransferase
APZ19_RS04205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APZ19_RS04225	COG1960	acyl-CoA dehydrogenase activity
APZ19_RS04230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APZ19_RS04235	COG0121	glutamine amidotransferase
APZ19_RS04240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APZ19_RS04245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APZ19_RS04250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APZ19_RS04255	COG2233	PERMEase
APZ19_RS04275	COG1393	Belongs to the ArsC family
APZ19_RS04280	COG4783	chaperone-mediated protein folding
APZ19_RS04295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APZ19_RS04300	COG2716	regulation of RNA biosynthetic process
APZ19_RS04305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APZ19_RS04310	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
APZ19_RS04330	COG1393	Belongs to the ArsC family
APZ19_RS04355	COG2837	iron assimilation
APZ19_RS04360	COG2169	Transcriptional regulator
APZ19_RS04365	COG1486	melibiose metabolic process
APZ19_RS04380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ19_RS04390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ19_RS04395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ19_RS04400	COG1334	flagellar protein FlaG
APZ19_RS04405	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APZ19_RS04415	COG1516	flagellar protein fliS
APZ19_RS04435	COG1677	Flagellar hook-basal body complex protein FliE
APZ19_RS04445	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APZ19_RS04500	COG1987	bacterial-type flagellum assembly
APZ19_RS04505	COG1684	flagellar biosynthetic protein fliR
APZ19_RS04540	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
APZ19_RS04545	COG2198	Histidine kinase
APZ19_RS04545	COG0784	Response regulator, receiver
APZ19_RS04545	COG0643	Histidine kinase
APZ19_RS04550	COG2201	protein-glutamate methylesterase activity
APZ19_RS04555	COG1192	Involved in chromosome partitioning
APZ19_RS04565	COG0835	chemotaxis
APZ19_RS04575	COG4133	protoheme IX ABC transporter activity
APZ19_RS04580	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APZ19_RS04585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APZ19_RS04600	COG1138	Cytochrome C-type biogenesis protein
APZ19_RS04605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APZ19_RS04615	COG3088	subunit of a heme lyase
APZ19_RS04615	COG4235	cytochrome complex assembly
APZ19_RS04620	COG2853	Lipoprotein
APZ19_RS04625	COG2067	long-chain fatty acid transport protein
APZ19_RS04630	COG2067	long-chain fatty acid transport protein
APZ19_RS04645	COG0183	Belongs to the thiolase family
APZ19_RS04660	COG2062	phosphohistidine phosphatase, SixA
APZ19_RS04665	COG2840	Smr protein MutS2
APZ19_RS04670	COG2890	protein-(glutamine-N5) methyltransferase activity
APZ19_RS04680	COG2860	membrane
APZ19_RS04685	COG3101	peptidyl-lysine hydroxylation
APZ19_RS04705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APZ19_RS04710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APZ19_RS04715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APZ19_RS04735	COG0285	dihydrofolate synthase activity
APZ19_RS04740	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
APZ19_RS04745	COG1286	toxin biosynthetic process
APZ19_RS04750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APZ19_RS04755	COG0583	DNA-binding transcription factor activity
APZ19_RS04760	COG0745	RESPONSE REGULATOR receiver
APZ19_RS04770	COG2832	Protein of unknown function (DUF454)
APZ19_RS04780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APZ19_RS04790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APZ19_RS04795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APZ19_RS04800	COG0814	amino acid
APZ19_RS04805	COG0251	oxidation-reduction process
APZ19_RS04815	COG2964	Protein conserved in bacteria
APZ19_RS04830	COG2983	Belongs to the UPF0260 family
APZ19_RS04835	COG2261	transglycosylase associated protein
APZ19_RS04840	COG2985	domain, Protein
APZ19_RS04845	COG0076	glutamate decarboxylase activity
APZ19_RS04850	COG0668	transmembrane transport
APZ19_RS04860	COG0346	lactoylglutathione lyase activity
APZ19_RS04870	COG1785	Belongs to the alkaline phosphatase family
APZ19_RS04885	COG2226	methyltransferase
APZ19_RS04910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APZ19_RS04915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APZ19_RS04925	COG3139	Protein of unknown function (DUF1315)
APZ19_RS04930	COG0252	asparaginase activity
APZ19_RS04935	COG0616	signal peptide processing
APZ19_RS04940	COG0446	pyridine nucleotide-disulphide oxidoreductase
APZ19_RS04940	COG1902	pentaerythritol trinitrate reductase activity
APZ19_RS04945	COG0778	Nitroreductase
APZ19_RS04950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APZ19_RS04965	COG0123	including yeast histone deacetylase and acetoin utilization protein
APZ19_RS04970	COG4269	membrane
APZ19_RS04985	COG3083	sulfuric ester hydrolase activity
APZ19_RS05010	COG1757	Na H antiporter
APZ19_RS05015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APZ19_RS05020	COG2165	general secretion pathway protein
APZ19_RS05025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APZ19_RS05030	COG2095	MarC family integral membrane protein
APZ19_RS05035	COG1454	alcohol dehydrogenase
APZ19_RS05035	COG1012	belongs to the aldehyde dehydrogenase family
APZ19_RS05055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APZ19_RS05060	COG4974	Belongs to the 'phage' integrase family
APZ19_RS05115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APZ19_RS05115	COG2885	chlorophyll binding
APZ19_RS05170	COG2003	Belongs to the UPF0758 family
APZ19_RS05245	COG3504	Conjugal transfer protein
APZ19_RS05270	COG3451	type IV secretory pathway VirB4
APZ19_RS05305	COG2056	Na+-H+ antiporter family
APZ19_RS05315	COG2885	chlorophyll binding
APZ19_RS05325	COG0346	lactoylglutathione lyase activity
APZ19_RS05330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APZ19_RS05335	COG4660	Part of a membrane complex involved in electron transport
APZ19_RS05340	COG4659	FMN binding
APZ19_RS05345	COG4658	electron transport chain
APZ19_RS05350	COG4656	Part of a membrane complex involved in electron transport
APZ19_RS05360	COG4657	Part of a membrane complex involved in electron transport
APZ19_RS05365	COG1882	Formate acetyltransferase
APZ19_RS05380	COG0556	nucleotide-excision repair
APZ19_RS05395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
APZ19_RS05400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APZ19_RS05405	COG0521	Mo-molybdopterin cofactor biosynthetic process
APZ19_RS05415	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APZ19_RS05420	COG0314	molybdopterin synthase activity
APZ19_RS05430	COG0601	transmembrane transport
APZ19_RS05435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APZ19_RS05440	COG0444	Belongs to the ABC transporter superfamily
APZ19_RS05450	COG0435	Glutathione S-transferase
APZ19_RS05455	COG3174	membrane
APZ19_RS05465	COG0857	belongs to the CobB CobQ family
APZ19_RS05465	COG0280	phosphate acetyltransferase
APZ19_RS05485	COG4120	Belongs to the binding-protein-dependent transport system permease family
APZ19_RS05490	COG1122	ATPase activity
APZ19_RS05495	COG0366	Alpha amylase catalytic
APZ19_RS05505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APZ19_RS05510	COG3318	Belongs to the UPF0149 family
APZ19_RS05510	COG3012	SEC-C Motif Domain Protein
APZ19_RS05515	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APZ19_RS05525	COG2186	Transcriptional regulator
APZ19_RS05570	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
APZ19_RS05575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APZ19_RS05580	COG0659	secondary active sulfate transmembrane transporter activity
APZ19_RS05585	COG1530	ribonuclease E activity
APZ19_RS05590	COG0564	pseudouridine synthase activity
APZ19_RS05595	COG0424	maF-like protein
APZ19_RS05600	COG1399	metal-binding, possibly nucleic acid-binding protein
APZ19_RS05615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APZ19_RS05645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APZ19_RS05660	COG0084	hydrolase, TatD family'
APZ19_RS05665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS05665	COG1263	PTS System
APZ19_RS05680	COG0733	neurotransmitter:sodium symporter activity
APZ19_RS05695	COG4667	esterase of the alpha-beta hydrolase superfamily
APZ19_RS05705	COG1940	carbohydrate kinase activity
APZ19_RS05710	COG0784	Response regulator, receiver
APZ19_RS05710	COG0835	chemotaxis
APZ19_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS05735	COG0616	signal peptide processing
APZ19_RS05745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APZ19_RS05750	COG0539	negative regulation of cytoplasmic translation
APZ19_RS05760	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APZ19_RS05765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APZ19_RS05775	COG4166	transmembrane transport
APZ19_RS05835	COG3119	arylsulfatase activity
APZ19_RS05840	COG1309	transcriptional regulator
APZ19_RS05845	COG3009	Protein conserved in bacteria
APZ19_RS05850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APZ19_RS05850	COG3008	intermembrane lipid transfer
APZ19_RS05855	COG2995	paraquat-inducible protein a
APZ19_RS05865	COG3258	Cytochrome c
APZ19_RS05870	COG2863	cytochrome
APZ19_RS05900	COG3250	beta-galactosidase activity
APZ19_RS05910	COG4580	involved in the transport of maltose and maltodextrins
APZ19_RS05920	COG2211	Major facilitator Superfamily
APZ19_RS05925	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
APZ19_RS05940	COG4232	protein-disulfide reductase activity
APZ19_RS05945	COG3118	belongs to the thioredoxin family
APZ19_RS05955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APZ19_RS05965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APZ19_RS05975	COG3153	acetyltransferase
APZ19_RS06015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS06025	COG0577	efflux transmembrane transporter activity
APZ19_RS06025	COG1136	(ABC) transporter
APZ19_RS06030	COG0577	efflux transmembrane transporter activity
APZ19_RS06030	COG1136	(ABC) transporter
APZ19_RS06035	COG1136	(ABC) transporter
APZ19_RS06035	COG0577	efflux transmembrane transporter activity
APZ19_RS06045	COG2176	DNA-directed DNA polymerase activity
APZ19_RS06115	COG5002	protein histidine kinase activity
APZ19_RS06115	COG3850	Histidine kinase
APZ19_RS06120	COG0745	RESPONSE REGULATOR receiver
APZ19_RS06125	COG0463	Glycosyl transferase, family 2
APZ19_RS06130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APZ19_RS06140	COG0840	transmembrane signaling receptor activity
APZ19_RS06145	COG2964	Protein conserved in bacteria
APZ19_RS06160	COG0446	pyridine nucleotide-disulphide oxidoreductase
APZ19_RS06180	COG1032	radical SAM domain protein
APZ19_RS06185	COG5001	Diguanylate cyclase
APZ19_RS06185	COG4251	negative regulation of phosphorylation
APZ19_RS06185	COG3706	GGDEF domain
APZ19_RS06185	COG2203	Gaf domain
APZ19_RS06215	COG2350	Protein conserved in bacteria
APZ19_RS06245	COG1301	dicarboxylic acid transport
APZ19_RS06250	COG0159	tryptophan synthase activity
APZ19_RS06260	COG0135	phosphoribosylanthranilate isomerase activity
APZ19_RS06260	COG0134	indole-3-glycerol-phosphate synthase activity
APZ19_RS06270	COG0512	Glutamine amidotransferase of anthranilate synthase
APZ19_RS06275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APZ19_RS06285	COG0613	PHP domain protein
APZ19_RS06290	COG0009	L-threonylcarbamoyladenylate synthase
APZ19_RS06300	COG1187	pseudouridine synthase activity
APZ19_RS06320	COG0417	DNA replication proofreading
APZ19_RS06325	COG2197	response regulator
APZ19_RS06330	COG0322	excinuclease ABC activity
APZ19_RS06370	COG0019	diaminopimelate decarboxylase activity
APZ19_RS06395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APZ19_RS06400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APZ19_RS06405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APZ19_RS06425	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APZ19_RS06435	COG0437	4 iron, 4 sulfur cluster binding
APZ19_RS06440	COG3301	Polysulphide reductase, NrfD
APZ19_RS06445	COG1138	Cytochrome C-type biogenesis protein
APZ19_RS06455	COG3088	subunit of a heme lyase
APZ19_RS06455	COG4235	cytochrome complex assembly
APZ19_RS06465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APZ19_RS06490	COG2989	Protein conserved in bacteria
APZ19_RS06495	COG3108	Peptidase M15
APZ19_RS06500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APZ19_RS06515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APZ19_RS06540	COG1846	Transcriptional regulator
APZ19_RS06545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ19_RS06550	COG0840	transmembrane signaling receptor activity
APZ19_RS06570	COG1448	Aminotransferase
APZ19_RS06575	COG2770	Histidine kinase
APZ19_RS06575	COG3437	response regulator, receiver
APZ19_RS06580	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APZ19_RS06590	COG1609	Transcriptional regulator
APZ19_RS06605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APZ19_RS06620	COG0017	Asparaginyl-tRNA synthetase
APZ19_RS06630	COG0720	synthase
APZ19_RS06635	COG2197	response regulator
APZ19_RS06645	COG5001	Diguanylate cyclase
APZ19_RS06645	COG3300	MHYT domain
APZ19_RS06650	COG1760	l-serine dehydratase
APZ19_RS06655	COG0814	amino acid
APZ19_RS06670	COG0784	Response regulator, receiver
APZ19_RS06670	COG2205	protein histidine kinase activity
APZ19_RS06675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APZ19_RS06690	COG3106	COG3106 Predicted ATPase
APZ19_RS06705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APZ19_RS06910	COG2801	Transposase and inactivated derivatives
APZ19_RS07290	COG1403	HNH endonuclease
APZ19_RS07380	COG2801	Transposase and inactivated derivatives
APZ19_RS07440	COG1733	regulation of RNA biosynthetic process
APZ19_RS07450	COG3340	Belongs to the peptidase S51 family
APZ19_RS07465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APZ19_RS07480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APZ19_RS07480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APZ19_RS07490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APZ19_RS07495	COG1609	Transcriptional regulator
APZ19_RS07505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APZ19_RS07535	COG0456	acetyltransferase
APZ19_RS07540	COG0471	metal ion transport
APZ19_RS07545	COG4191	Histidine kinase
APZ19_RS07545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APZ19_RS07555	COG5001	Diguanylate cyclase
APZ19_RS07555	COG3300	MHYT domain
APZ19_RS07565	COG1280	lysine exporter protein (LysE YggA)
APZ19_RS07570	COG1328	CTP reductase activity
APZ19_RS07575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APZ19_RS07585	COG0861	Integral membrane protein TerC family
APZ19_RS07595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
APZ19_RS07605	COG3706	GGDEF domain
APZ19_RS07620	COG0814	amino acid
APZ19_RS07640	COG1132	(ABC) transporter
APZ19_RS07645	COG1132	(ABC) transporter
APZ19_RS07650	COG2165	general secretion pathway protein
APZ19_RS07660	COG0583	DNA-binding transcription factor activity
APZ19_RS07685	COG0443	Heat shock 70 kDa protein
APZ19_RS07690	COG0443	Heat shock 70 kDa protein
APZ19_RS07700	COG3706	GGDEF domain
APZ19_RS07725	COG3227	Zinc metalloprotease (Elastase)
APZ19_RS07735	COG0243	molybdopterin cofactor binding
APZ19_RS07740	COG0437	4 iron, 4 sulfur cluster binding
APZ19_RS07745	COG3302	dmso reductase anchor subunit
APZ19_RS07760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APZ19_RS07765	COG1643	Atp-dependent helicase
APZ19_RS07790	COG3063	Type IV pilus biogenesis stability protein PilW
APZ19_RS07825	COG0531	amino acid
APZ19_RS07830	COG1280	lysine exporter protein (LysE YggA)
APZ19_RS07835	COG0583	DNA-binding transcription factor activity
APZ19_RS07840	COG0702	epimerase
APZ19_RS07845	COG0583	DNA-binding transcription factor activity
APZ19_RS07850	COG1560	Kdo2-lipid A biosynthetic process
APZ19_RS07865	COG1846	Transcriptional regulator
APZ19_RS07880	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
APZ19_RS07885	COG1280	lysine exporter protein (LysE YggA)
APZ19_RS07915	COG1115	amino acid carrier protein
APZ19_RS07970	COG0583	DNA-binding transcription factor activity
APZ19_RS07975	COG1368	sulfuric ester hydrolase activity
APZ19_RS07980	COG0215	cysteine-tRNA ligase activity
APZ19_RS07985	COG0534	Mate efflux family protein
APZ19_RS07990	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
APZ19_RS08000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ19_RS08005	COG0456	acetyltransferase
APZ19_RS08010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APZ19_RS08015	COG0662	Cupin 2, conserved barrel domain protein
APZ19_RS08020	COG0527	aspartate kinase activity
APZ19_RS08035	COG0583	DNA-binding transcription factor activity
APZ19_RS08040	COG1858	cytochrome C peroxidase
APZ19_RS08045	COG1404	Belongs to the peptidase S8 family
APZ19_RS08050	COG0583	DNA-binding transcription factor activity
APZ19_RS08070	COG2169	Transcriptional regulator
APZ19_RS08075	COG0697	spore germination
APZ19_RS08080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APZ19_RS08085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
APZ19_RS08095	COG0583	DNA-binding transcription factor activity
APZ19_RS08100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APZ19_RS08120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS08135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APZ19_RS08140	COG3290	protein histidine kinase activity
APZ19_RS08145	COG4565	transcriptional regulatory protein
APZ19_RS08150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APZ19_RS08155	COG0363	glucosamine-6-phosphate deaminase activity
APZ19_RS08160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APZ19_RS08190	COG3284	Transcriptional regulator
APZ19_RS08195	COG1012	belongs to the aldehyde dehydrogenase family
APZ19_RS08200	COG1902	pentaerythritol trinitrate reductase activity
APZ19_RS08210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ19_RS08215	COG2358	TRAP transporter, solute receptor (TAXI family
APZ19_RS08225	COG0730	response to heat
APZ19_RS08260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
APZ19_RS08265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
APZ19_RS08375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APZ19_RS08380	COG0372	Belongs to the citrate synthase family
APZ19_RS08385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APZ19_RS08390	COG2828	Protein conserved in bacteria
APZ19_RS08415	COG0561	phosphatase activity
APZ19_RS08420	COG0602	queuosine metabolic process
APZ19_RS08430	COG3706	GGDEF domain
APZ19_RS08480	COG1254	Belongs to the acylphosphatase family
APZ19_RS08485	COG2920	part of a sulfur-relay system
APZ19_RS08495	COG0670	Belongs to the BI1 family
APZ19_RS08500	COG1126	abc transporter atp-binding protein
APZ19_RS08505	COG0765	amino acid transport
APZ19_RS08510	COG4597	amino acid ABC transporter
APZ19_RS08515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APZ19_RS08530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APZ19_RS08555	COG3008	intermembrane lipid transfer
APZ19_RS08560	COG2995	paraquat-inducible protein a
APZ19_RS08565	COG1132	(ABC) transporter
APZ19_RS08570	COG1956	GAF domain-containing protein
APZ19_RS08575	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
APZ19_RS08580	COG0793	Belongs to the peptidase S41A family
APZ19_RS08590	COG0308	aminopeptidase N
APZ19_RS08600	COG2902	Dehydrogenase
APZ19_RS08625	COG0488	(ABC) transporter
APZ19_RS08645	COG1067	ATP-dependent peptidase activity
APZ19_RS08675	COG2205	protein histidine kinase activity
APZ19_RS08675	COG0784	Response regulator, receiver
APZ19_RS08690	COG3278	Belongs to the heme-copper respiratory oxidase family
APZ19_RS08705	COG2010	Cytochrome c
APZ19_RS08715	COG2217	Heavy metal translocating P-type atpase
APZ19_RS08730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APZ19_RS08735	COG0589	response to stress
APZ19_RS08760	COG3842	ATPase activity
APZ19_RS08770	COG1177	transmembrane transport
APZ19_RS08780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APZ19_RS08785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APZ19_RS08800	COG0437	4 iron, 4 sulfur cluster binding
APZ19_RS08805	COG0243	molybdopterin cofactor binding
APZ19_RS08805	COG3383	formate dehydrogenase (NAD+) activity
APZ19_RS08815	COG3381	protein complex oligomerization
APZ19_RS08835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APZ19_RS08840	COG0488	(ABC) transporter
APZ19_RS08860	COG4191	Histidine kinase
APZ19_RS08865	COG2204	response regulator
APZ19_RS08875	COG4662	Binding-protein-dependent transport system inner membrane component
APZ19_RS08880	COG3842	ATPase activity
APZ19_RS08890	COG0303	'Molybdopterin
APZ19_RS08905	COG1940	carbohydrate kinase activity
APZ19_RS08910	COG3148	PFAM DTW domain containing protein
APZ19_RS08955	COG0840	transmembrane signaling receptor activity
APZ19_RS08960	COG0791	NLP P60 protein
APZ19_RS08970	COG3706	GGDEF domain
APZ19_RS08975	COG2201	protein-glutamate methylesterase activity
APZ19_RS08980	COG3001	Fructosamine kinase
APZ19_RS08990	COG0307	riboflavin synthase, alpha
APZ19_RS08995	COG0534	Mate efflux family protein
APZ19_RS09005	COG1793	dna ligase
APZ19_RS09015	COG2885	chlorophyll binding
APZ19_RS09035	COG2204	response regulator
APZ19_RS09045	COG0438	transferase activity, transferring glycosyl groups
APZ19_RS09085	COG0297	glycogen (starch) synthase activity
APZ19_RS09090	COG1215	transferase activity, transferring glycosyl groups
APZ19_RS09095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APZ19_RS09105	COG3064	Membrane
APZ19_RS09130	COG5001	Diguanylate cyclase
APZ19_RS09130	COG3300	MHYT domain
APZ19_RS09135	COG2205	protein histidine kinase activity
APZ19_RS09135	COG3437	response regulator, receiver
APZ19_RS09135	COG3850	Histidine kinase
APZ19_RS09135	COG4999	Histidine kinase
APZ19_RS09155	COG0110	maltose O-acetyltransferase activity
APZ19_RS09160	COG2205	protein histidine kinase activity
APZ19_RS09160	COG0784	Response regulator, receiver
APZ19_RS09325	COG0860	N-Acetylmuramoyl-L-alanine amidase
APZ19_RS09325	COG3409	Peptidoglycan-binding domain 1 protein
APZ19_RS09385	COG3081	Nucleoid-associated protein
APZ19_RS09415	COG2842	Transposition protein
APZ19_RS09440	COG1846	Transcriptional regulator
APZ19_RS09455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APZ19_RS09460	COG3247	response to pH
APZ19_RS09465	COG0668	transmembrane transport
APZ19_RS09480	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
APZ19_RS09495	COG0745	RESPONSE REGULATOR receiver
APZ19_RS09560	COG0519	Catalyzes the synthesis of GMP from XMP
APZ19_RS09565	COG0589	response to stress
APZ19_RS09580	COG1454	alcohol dehydrogenase
APZ19_RS09585	COG0235	Class ii aldolase
APZ19_RS09590	COG4154	Belongs to the RbsD FucU family
APZ19_RS09595	COG1070	Carbohydrate kinase
APZ19_RS09600	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
APZ19_RS09605	COG0738	Major facilitator superfamily
APZ19_RS09610	COG1349	DNA-binding transcription factor activity
APZ19_RS09625	COG2197	response regulator
APZ19_RS09640	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
APZ19_RS09655	COG2301	Belongs to the HpcH HpaI aldolase family
APZ19_RS09665	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
APZ19_RS09675	COG3630	sodium ion export across plasma membrane
APZ19_RS09680	COG5016	pyruvate
APZ19_RS09680	COG0511	ligase activity, forming carbon-carbon bonds
APZ19_RS09685	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APZ19_RS09695	COG4565	transcriptional regulatory protein
APZ19_RS09720	COG0657	acetylesterase activity
APZ19_RS09730	COG0625	glutathione transferase activity
APZ19_RS09740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
APZ19_RS09755	COG2195	Cleaves the N-terminal amino acid of tripeptides
APZ19_RS09775	COG1451	nucleotide metabolic process
APZ19_RS09780	COG2165	general secretion pathway protein
APZ19_RS09805	COG0583	DNA-binding transcription factor activity
APZ19_RS09835	COG4139	cobalamin transport
APZ19_RS09860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APZ19_RS09870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APZ19_RS09875	COG0702	epimerase
APZ19_RS09880	COG1823	symporter activity
APZ19_RS09890	COG2925	Exonuclease
APZ19_RS09900	COG1346	cytolysis
APZ19_RS09945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS09950	COG1621	beta-fructofuranosidase activity
APZ19_RS09960	COG0072	phenylalanine-tRNA ligase activity
APZ19_RS09960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APZ19_RS09970	COG2199	diguanylate cyclase activity
APZ19_RS10010	COG0251	oxidation-reduction process
APZ19_RS10030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APZ19_RS10055	COG2188	Transcriptional regulator
APZ19_RS10065	COG0010	Belongs to the arginase family
APZ19_RS10075	COG2986	histidine ammonia-lyase
APZ19_RS10090	COG0247	lactate metabolic process
APZ19_RS10090	COG0277	FAD linked oxidase domain protein
APZ19_RS10145	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
APZ19_RS10150	COG1643	Atp-dependent helicase
APZ19_RS10160	COG2949	membrane
APZ19_RS10165	COG0471	metal ion transport
APZ19_RS10170	COG3706	GGDEF domain
APZ19_RS10190	COG0492	ferredoxin-NADP+ reductase activity
APZ19_RS10195	COG4988	ABC transporter
APZ19_RS10200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APZ19_RS10210	COG0583	DNA-binding transcription factor activity
APZ19_RS10215	COG2200	EAL domain
APZ19_RS10255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APZ19_RS10265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APZ19_RS10265	COG4191	Histidine kinase
APZ19_RS10280	COG3070	regulator of competence-specific genes
APZ19_RS10295	COG2431	L-lysine efflux transmembrane transporter activity
APZ19_RS10305	COG0076	glutamate decarboxylase activity
APZ19_RS10310	COG1737	Transcriptional regulator
APZ19_RS10320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APZ19_RS10330	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APZ19_RS10360	COG4181	ATPase activity
APZ19_RS10365	COG0534	Mate efflux family protein
APZ19_RS10370	COG0702	epimerase
APZ19_RS10375	COG4667	esterase of the alpha-beta hydrolase superfamily
APZ19_RS10385	COG2814	Major facilitator Superfamily
APZ19_RS10390	COG1187	pseudouridine synthase activity
APZ19_RS10395	COG1061	Type III restriction enzyme res subunit
APZ19_RS10400	COG2199	diguanylate cyclase activity
APZ19_RS10455	COG3313	Fe-S protein
APZ19_RS10465	COG0659	secondary active sulfate transmembrane transporter activity
APZ19_RS10490	COG0493	'glutamate synthase
APZ19_RS10500	COG0398	Pfam SNARE associated Golgi protein
APZ19_RS10505	COG4134	Bacterial extracellular solute-binding protein
APZ19_RS10510	COG4135	transport system, permease component
APZ19_RS10515	COG4136	ATPase activity
APZ19_RS10520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APZ19_RS10525	COG3604	Transcriptional regulator
APZ19_RS10530	COG1151	hydroxylamine reductase activity
APZ19_RS10535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APZ19_RS10550	COG0564	pseudouridine synthase activity
APZ19_RS10560	COG0733	neurotransmitter:sodium symporter activity
APZ19_RS10570	COG0626	cystathionine gamma-synthase activity
APZ19_RS10575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
APZ19_RS10580	COG5380	lipid catabolic process
APZ19_RS10585	COG2818	Glycosylase
APZ19_RS10605	COG1983	PspC domain protein
APZ19_RS10615	COG1842	Phage shock protein A
APZ19_RS10620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
APZ19_RS10630	COG4168	peptide transport system, permease
APZ19_RS10635	COG4171	peptide transport system, permease
APZ19_RS10645	COG4172	Belongs to the ABC transporter superfamily
APZ19_RS10655	COG1227	inorganic diphosphatase activity
APZ19_RS10670	COG0243	molybdopterin cofactor binding
APZ19_RS10675	COG3005	denitrification pathway
APZ19_RS10680	COG4459	periplasmic nitrate reductase
APZ19_RS10685	COG0390	transport system, permease component
APZ19_RS10690	COG2116	formate transmembrane transporter activity
APZ19_RS10715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APZ19_RS10720	COG1435	thymidine kinase activity
APZ19_RS10725	COG0215	cysteine-tRNA ligase activity
APZ19_RS10730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APZ19_RS10735	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APZ19_RS10740	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
APZ19_RS10745	COG3012	SEC-C Motif Domain Protein
APZ19_RS10750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APZ19_RS10750	COG0140	phosphoribosyl-ATP diphosphatase activity
APZ19_RS10760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APZ19_RS10765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APZ19_RS10770	COG0131	Imidazoleglycerol-phosphate dehydratase
APZ19_RS10770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APZ19_RS10780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APZ19_RS10790	COG1757	Na H antiporter
APZ19_RS10800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS10820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APZ19_RS10830	COG2268	Band 7 protein
APZ19_RS10840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APZ19_RS10855	COG0300	oxidoreductase activity
APZ19_RS10895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APZ19_RS10900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APZ19_RS10915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APZ19_RS10925	COG1674	ftsk spoiiie
APZ19_RS10935	COG0686	Belongs to the AlaDH PNT family
APZ19_RS10945	COG0583	DNA-binding transcription factor activity
APZ19_RS10965	COG0800	Aldolase
APZ19_RS10970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS10975	COG1917	Cupin 2, conserved barrel domain protein
APZ19_RS11005	COG0402	S-adenosylhomocysteine deaminase activity
APZ19_RS11015	COG3181	Tripartite tricarboxylate transporter family receptor
APZ19_RS11030	COG4934	collagen metabolic process
APZ19_RS11040	COG3568	Endonuclease Exonuclease Phosphatase
APZ19_RS11065	COG0701	Predicted permease
APZ19_RS11085	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS11090	COG1917	Cupin 2, conserved barrel domain protein
APZ19_RS11100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APZ19_RS11105	COG1904	glucuronate isomerase
APZ19_RS11130	COG2186	Transcriptional regulator
APZ19_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS11140	COG2186	Transcriptional regulator
APZ19_RS11145	COG0517	IMP dehydrogenase activity
APZ19_RS11150	COG2176	DNA-directed DNA polymerase activity
APZ19_RS11160	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
APZ19_RS11175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APZ19_RS11195	COG1120	ATPase activity
APZ19_RS11200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APZ19_RS11205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APZ19_RS11225	COG1288	antiporter activity
APZ19_RS11235	COG2186	Transcriptional regulator
APZ19_RS11245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ19_RS11250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS11275	COG0747	negative chemotaxis
APZ19_RS11280	COG4608	Belongs to the ABC transporter superfamily
APZ19_RS11285	COG0444	Belongs to the ABC transporter superfamily
APZ19_RS11290	COG0534	Mate efflux family protein
APZ19_RS11315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APZ19_RS11320	COG2824	Alkylphosphonate utilization operon protein PhnA
APZ19_RS11325	COG2723	6-phospho-beta-galactosidase activity
APZ19_RS11330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS11330	COG1263	PTS System
APZ19_RS11345	COG3119	arylsulfatase activity
APZ19_RS11365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APZ19_RS11405	COG0514	ATP-dependent DNA helicase (RecQ)
APZ19_RS11410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APZ19_RS11415	COG0302	gtp cyclohydrolase
APZ19_RS11420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APZ19_RS11425	COG0602	queuosine metabolic process
APZ19_RS11470	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
APZ19_RS11500	COG5002	protein histidine kinase activity
APZ19_RS11500	COG0784	Response regulator, receiver
APZ19_RS11510	COG0754	glutathionylspermidine amidase activity
APZ19_RS11520	COG3766	membrane
APZ19_RS11535	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
APZ19_RS11540	COG2885	chlorophyll binding
APZ19_RS11545	COG0823	Involved in the tonB-independent uptake of proteins
APZ19_RS11560	COG0811	peptide transport
APZ19_RS11565	COG0824	Thioesterase
APZ19_RS11575	COG4890	Cyd operon protein YbgT
APZ19_RS11580	COG1294	oxidase, subunit
APZ19_RS11585	COG1271	oxidase subunit
APZ19_RS11595	COG0632	four-way junction helicase activity
APZ19_RS11600	COG0840	transmembrane signaling receptor activity
APZ19_RS11615	COG1801	Protein of unknown function DUF72
APZ19_RS11635	COG4067	protein conserved in archaea
APZ19_RS11635	COG0189	ligase activity
APZ19_RS11660	COG0318	PFAM AMP-dependent synthetase and ligase
APZ19_RS11675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APZ19_RS11680	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APZ19_RS11690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APZ19_RS11695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APZ19_RS11700	COG0745	RESPONSE REGULATOR receiver
APZ19_RS11720	COG3070	regulator of competence-specific genes
APZ19_RS11740	COG0297	glycogen (starch) synthase activity
APZ19_RS11745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APZ19_RS11750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APZ19_RS11780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APZ19_RS11785	COG0542	response to heat
APZ19_RS11795	COG1278	Cold shock
APZ19_RS11805	COG1187	pseudouridine synthase activity
APZ19_RS11810	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
APZ19_RS11820	COG1199	ATP-dependent helicase activity
APZ19_RS11825	COG0730	response to heat
APZ19_RS11830	COG3923	Primosomal replication protein n
APZ19_RS11840	COG0840	transmembrane signaling receptor activity
APZ19_RS11845	COG0708	Exodeoxyribonuclease III
APZ19_RS11855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS11895	COG1882	Formate acetyltransferase
APZ19_RS11905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APZ19_RS11920	COG2766	serine protein kinase
APZ19_RS11925	COG2718	Belongs to the UPF0229 family
APZ19_RS11930	COG2719	SpoVR family
APZ19_RS11950	COG1132	(ABC) transporter
APZ19_RS11965	COG4591	ABC-type transport system involved in lipoprotein release permease component
APZ19_RS11970	COG1136	(ABC) transporter
APZ19_RS11975	COG4591	ABC-type transport system involved in lipoprotein release permease component
APZ19_RS11985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APZ19_RS12000	COG1252	NADH dehydrogenase
APZ19_RS12030	COG0537	adenosine 5'-monophosphoramidase activity
APZ19_RS12035	COG0840	transmembrane signaling receptor activity
APZ19_RS12060	COG0516	GMP reductase activity
APZ19_RS12060	COG0517	IMP dehydrogenase activity
APZ19_RS12065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APZ19_RS12070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APZ19_RS12075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APZ19_RS12080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APZ19_RS12100	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APZ19_RS12130	COG2199	diguanylate cyclase activity
APZ19_RS12145	COG3126	Type III secretion system lipoprotein chaperone (YscW)
APZ19_RS12150	COG1946	Acyl-CoA thioesterase
APZ19_RS12160	COG1522	sequence-specific DNA binding
APZ19_RS12180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ19_RS12225	COG2855	membrane
APZ19_RS12235	COG0583	DNA-binding transcription factor activity
APZ19_RS12240	COG1263	PTS System
APZ19_RS12240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS12240	COG2190	(PTS) system
APZ19_RS12255	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APZ19_RS12260	COG0596	Alpha beta hydrolase
APZ19_RS12270	COG1169	isochorismate synthase
APZ19_RS12275	COG0436	Aminotransferase
APZ19_RS12280	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APZ19_RS12300	COG1555	photosystem II stabilization
APZ19_RS12305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APZ19_RS12310	COG0776	regulation of translation
APZ19_RS12315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APZ19_RS12345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APZ19_RS12350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APZ19_RS12355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APZ19_RS12375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APZ19_RS12380	COG0569	domain protein
APZ19_RS12385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ19_RS12390	COG0513	Belongs to the DEAD box helicase family
APZ19_RS12395	COG1253	flavin adenine dinucleotide binding
APZ19_RS12400	COG4771	TonB-dependent receptor
APZ19_RS12415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APZ19_RS12415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APZ19_RS12420	COG3433	isochorismatase activity
APZ19_RS12420	COG1535	isochorismatase
APZ19_RS12425	COG1021	2,3-dihydroxybenzoate-AMP ligase
APZ19_RS12430	COG1169	isochorismate synthase
APZ19_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS12485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APZ19_RS12490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APZ19_RS12510	COG1216	Glycosyl transferase, family 2
APZ19_RS12515	COG2986	histidine ammonia-lyase
APZ19_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS12575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APZ19_RS12585	COG2951	lytic endotransglycosylase activity
APZ19_RS12600	COG2894	cell division
APZ19_RS12605	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APZ19_RS12610	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APZ19_RS12615	COG0318	PFAM AMP-dependent synthetase and ligase
APZ19_RS12620	COG2267	carboxylic ester hydrolase activity
APZ19_RS12625	COG3065	identical protein binding
APZ19_RS12635	COG1214	PFAM Peptidase M22, glycoprotease
APZ19_RS12640	COG1199	ATP-dependent helicase activity
APZ19_RS12645	COG0788	formyltetrahydrofolate deformylase activity
APZ19_RS12650	COG3102	Protein conserved in bacteria
APZ19_RS12680	COG1918	ferrous iron import across plasma membrane
APZ19_RS12685	COG4977	sequence-specific DNA binding
APZ19_RS12690	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APZ19_RS12695	COG1121	(ABC) transporter
APZ19_RS12700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APZ19_RS12715	COG0508	dehydrogenase complex catalyzes the overall conversion of
APZ19_RS12720	COG0567	Dehydrogenase, E1 component
APZ19_RS12730	COG1053	succinate dehydrogenase
APZ19_RS12735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APZ19_RS12750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APZ19_RS12760	COG0033	Phosphoglucomutase
APZ19_RS12765	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APZ19_RS12770	COG0596	Alpha beta hydrolase
APZ19_RS12790	COG0735	belongs to the Fur family
APZ19_RS12795	COG2165	general secretion pathway protein
APZ19_RS12805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS12805	COG1263	PTS System
APZ19_RS12805	COG2190	(PTS) system
APZ19_RS12815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APZ19_RS12820	COG1940	carbohydrate kinase activity
APZ19_RS12820	COG1846	Transcriptional regulator
APZ19_RS12825	COG4651	solute:proton antiporter activity
APZ19_RS12825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APZ19_RS12830	COG0367	asparagine synthase
APZ19_RS12835	COG0250	Participates in transcription elongation, termination and antitermination
APZ19_RS12840	COG3104	oligopeptide transport
APZ19_RS12845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APZ19_RS12860	COG3710	Transcriptional regulator
APZ19_RS12880	COG0622	Phosphoesterase
APZ19_RS12910	COG1090	epimerase
APZ19_RS12915	COG0300	oxidoreductase activity
APZ19_RS12925	COG3118	belongs to the thioredoxin family
APZ19_RS12935	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
APZ19_RS12940	COG1215	transferase activity, transferring glycosyl groups
APZ19_RS12945	COG1215	transferase activity, transferring glycosyl groups
APZ19_RS12965	COG2194	sulfuric ester hydrolase activity
APZ19_RS12970	COG0330	HflC and HflK could
APZ19_RS13005	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
APZ19_RS13010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APZ19_RS13020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS13025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APZ19_RS13030	COG2190	(PTS) system
APZ19_RS13035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ19_RS13040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ19_RS13045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ19_RS13060	COG1705	Flagellar rod assembly protein muramidase FlgJ
APZ19_RS13060	COG3951	Flagellar rod assembly protein muramidase FlgJ
APZ19_RS13065	COG1706	bacterial-type flagellum-dependent cell motility
APZ19_RS13070	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APZ19_RS13080	COG4787	bacterial-type flagellum-dependent cell motility
APZ19_RS13085	COG1749	Flagellar hook protein flgE
APZ19_RS13095	COG1558	bacterial-type flagellum-dependent cell motility
APZ19_RS13100	COG1815	bacterial-type flagellum-dependent cell motility
APZ19_RS13105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APZ19_RS13110	COG0835	chemotaxis
APZ19_RS13110	COG0784	Response regulator, receiver
APZ19_RS13165	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
APZ19_RS13180	COG2608	mercury ion transmembrane transporter activity
APZ19_RS13180	COG2217	Heavy metal translocating P-type atpase
APZ19_RS13215	COG2840	Smr protein MutS2
APZ19_RS13220	COG1187	pseudouridine synthase activity
APZ19_RS13225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APZ19_RS13230	COG0737	Belongs to the 5'-nucleotidase family
APZ19_RS13240	COG2912	Transglutaminase-like superfamily
APZ19_RS13245	COG3094	Invasion gene expression up-regulator, SirB
APZ19_RS13250	COG2890	protein-(glutamine-N5) methyltransferase activity
APZ19_RS13275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APZ19_RS13395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APZ19_RS13410	COG1702	phosphate starvation-inducible protein PhoH
APZ19_RS13420	COG4535	Mg2 and Co2 transporter CorC
APZ19_RS13425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APZ19_RS13430	COG2888	peptidyl-tyrosine sulfation
APZ19_RS13435	COG0495	leucyl-tRNA aminoacylation
APZ19_RS13440	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
APZ19_RS13445	COG1466	dna polymerase III delta subunit
APZ19_RS13450	COG0799	negative regulation of ribosome biogenesis
APZ19_RS13460	COG0768	penicillin binding
APZ19_RS13465	COG0772	Belongs to the SEDS family
APZ19_RS13470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APZ19_RS13475	COG1686	Belongs to the peptidase S11 family
APZ19_RS13495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APZ19_RS13500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APZ19_RS13515	COG0366	Alpha amylase catalytic
APZ19_RS13520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS13520	COG1263	PTS System
APZ19_RS13530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APZ19_RS13535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APZ19_RS13540	COG2011	ABC-type metal ion transport system permease component
APZ19_RS13545	COG1464	Belongs to the NlpA lipoprotein family
APZ19_RS13555	COG0737	Belongs to the 5'-nucleotidase family
APZ19_RS13560	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
APZ19_RS13585	COG1611	Belongs to the LOG family
APZ19_RS13600	COG2363	Small membrane protein
APZ19_RS13610	COG0583	DNA-binding transcription factor activity
APZ19_RS13625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APZ19_RS13635	COG0142	geranyltranstransferase activity
APZ19_RS13645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APZ19_RS13650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APZ19_RS13675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APZ19_RS13675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APZ19_RS13680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APZ19_RS13685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APZ19_RS13700	COG1073	alpha beta
APZ19_RS13710	COG2252	PERMEase
APZ19_RS13715	COG2195	Cleaves the N-terminal amino acid of tripeptides
APZ19_RS13745	COG0047	phosphoribosylformylglycinamidine synthase activity
APZ19_RS13745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APZ19_RS13765	COG0590	tRNA wobble adenosine to inosine editing
APZ19_RS13770	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
APZ19_RS13790	COG4969	Belongs to the N-Me-Phe pilin family
APZ19_RS13815	COG1301	dicarboxylic acid transport
APZ19_RS13835	COG0497	DNA recombination
APZ19_RS13840	COG0456	acetyltransferase
APZ19_RS13845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ19_RS13855	COG2914	Belongs to the UPF0125 (RnfH) family
APZ19_RS13860	COG2867	negative regulation of translational initiation
APZ19_RS13875	COG0583	DNA-binding transcription factor activity
APZ19_RS13880	COG1289	transmembrane transporter activity
APZ19_RS13900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APZ19_RS13905	COG2873	o-acetylhomoserine
APZ19_RS13910	COG0668	transmembrane transport
APZ19_RS13925	COG0583	DNA-binding transcription factor activity
APZ19_RS13935	COG1115	amino acid carrier protein
APZ19_RS13940	COG1584	GPR1 FUN34 yaaH family protein
APZ19_RS13950	COG1757	Na H antiporter
APZ19_RS13960	COG0516	GMP reductase activity
APZ19_RS13960	COG0517	IMP dehydrogenase activity
APZ19_RS13975	COG2199	diguanylate cyclase activity
APZ19_RS13975	COG2203	Gaf domain
APZ19_RS13990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ19_RS13995	COG2976	Protein conserved in bacteria
APZ19_RS14030	COG2975	iron-sulfur cluster assembly
APZ19_RS14035	COG0633	Ferredoxin
APZ19_RS14050	COG0316	Belongs to the HesB IscA family
APZ19_RS14055	COG0822	iron-sulfur transferase activity
APZ19_RS14070	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APZ19_RS14075	COG0483	inositol monophosphate 1-phosphatase activity
APZ19_RS14080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APZ19_RS14085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APZ19_RS14090	COG1862	Preprotein translocase
APZ19_RS14115	COG0517	IMP dehydrogenase activity
APZ19_RS14125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APZ19_RS14130	COG0583	DNA-binding transcription factor activity
APZ19_RS14135	COG0450	alkyl hydroperoxide reductase
APZ19_RS14165	COG0704	Plays a role in the regulation of phosphate uptake
APZ19_RS14170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APZ19_RS14175	COG0581	inorganic phosphate transmembrane transporter activity
APZ19_RS14180	COG0573	inorganic phosphate transmembrane transporter activity
APZ19_RS14185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APZ19_RS14190	COG0248	Ppx GppA phosphatase
APZ19_RS14200	COG5002	protein histidine kinase activity
APZ19_RS14205	COG0745	RESPONSE REGULATOR receiver
APZ19_RS14215	COG0826	peptidase U32
APZ19_RS14220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APZ19_RS14280	COG0542	response to heat
APZ19_RS14285	COG1496	oxidoreductase activity
APZ19_RS14290	COG0564	pseudouridine synthase activity
APZ19_RS14295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ19_RS14300	COG0741	lytic transglycosylase activity
APZ19_RS14305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APZ19_RS14310	COG0077	Prephenate dehydratase
APZ19_RS14310	COG1605	Chorismate mutase
APZ19_RS14315	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
APZ19_RS14330	COG0488	(ABC) transporter
APZ19_RS14340	COG0739	heme binding
APZ19_RS14345	COG1605	Chorismate mutase
APZ19_RS14345	COG0287	Prephenate dehydrogenase
APZ19_RS14350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APZ19_RS14360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APZ19_RS14380	COG1966	Carbon starvation protein
APZ19_RS14385	COG3275	phosphorelay sensor kinase activity
APZ19_RS14390	COG3279	Response regulator of the LytR AlgR family
APZ19_RS14395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APZ19_RS14400	COG1047	Peptidyl-prolyl cis-trans
APZ19_RS14415	COG0196	riboflavin kinase activity
APZ19_RS14420	COG0728	peptidoglycan biosynthetic process
APZ19_RS14425	COG0268	Binds directly to 16S ribosomal RNA
APZ19_RS14430	COG0640	Transcriptional regulator
APZ19_RS14435	COG0583	DNA-binding transcription factor activity
APZ19_RS14440	COG1283	sodium-dependent phosphate transmembrane transporter activity
APZ19_RS14455	COG0730	response to heat
APZ19_RS14480	COG0667	Aldo Keto reductase
APZ19_RS14505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APZ19_RS14510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APZ19_RS14515	COG4974	Belongs to the 'phage' integrase family
APZ19_RS14520	COG0716	FMN binding
APZ19_RS14535	COG0513	Belongs to the DEAD box helicase family
APZ19_RS14545	COG3022	response to hydroperoxide
APZ19_RS14550	COG1115	amino acid carrier protein
APZ19_RS14590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APZ19_RS14595	COG0083	homoserine kinase activity
APZ19_RS14610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APZ19_RS14625	COG0745	RESPONSE REGULATOR receiver
APZ19_RS14635	COG2198	Histidine kinase
APZ19_RS14635	COG0784	Response regulator, receiver
APZ19_RS14635	COG5002	protein histidine kinase activity
APZ19_RS14640	COG5001	Diguanylate cyclase
APZ19_RS14640	COG4251	negative regulation of phosphorylation
APZ19_RS14640	COG3706	GGDEF domain
APZ19_RS14640	COG2203	Gaf domain
APZ19_RS14645	COG1242	4 iron, 4 sulfur cluster binding
APZ19_RS14650	COG0070	glutamate synthase
APZ19_RS14650	COG0069	glutamate synthase activity
APZ19_RS14650	COG0067	glutamate synthase
APZ19_RS14660	COG0070	glutamate synthase
APZ19_RS14660	COG0067	glutamate synthase
APZ19_RS14660	COG0069	glutamate synthase activity
APZ19_RS14665	COG0493	'glutamate synthase
APZ19_RS14690	COG2860	membrane
APZ19_RS14695	COG0583	DNA-binding transcription factor activity
APZ19_RS14700	COG0730	response to heat
APZ19_RS14715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APZ19_RS14720	COG0505	Belongs to the CarA family
APZ19_RS14730	COG0494	nUDIX hydrolase
APZ19_RS14750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APZ19_RS14755	COG0849	cell division
APZ19_RS14760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APZ19_RS14775	COG0772	Belongs to the SEDS family
APZ19_RS14790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APZ19_RS14795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APZ19_RS14800	COG0768	penicillin binding
APZ19_RS14805	COG3116	cell division
APZ19_RS14825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APZ19_RS14840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APZ19_RS14845	COG2823	Periplasmic or secreted lipoprotein
APZ19_RS14850	COG2969	positive regulation of protein catabolic process
APZ19_RS14855	COG0625	glutathione transferase activity
APZ19_RS14860	COG2857	Cytochrome c1
APZ19_RS14865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APZ19_RS14870	COG0723	plastoquinol--plastocyanin reductase activity
APZ19_RS14890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APZ19_RS14900	COG3105	Protein conserved in bacteria
APZ19_RS14905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APZ19_RS14910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APZ19_RS14915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APZ19_RS14925	COG3150	esterase
APZ19_RS14935	COG3151	Protein conserved in bacteria
APZ19_RS14940	COG0494	nUDIX hydrolase
APZ19_RS14945	COG1538	Outer membrane efflux protein
APZ19_RS14955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
APZ19_RS14965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APZ19_RS14970	COG3025	triphosphatase activity
APZ19_RS14975	COG1392	Phosphate transport regulator
APZ19_RS14980	COG0306	phosphate transporter
APZ19_RS14985	COG4991	sh3 domain protein
APZ19_RS14990	COG0405	Gamma-glutamyltransferase
APZ19_RS15000	COG3267	Type II secretory pathway component ExeA
APZ19_RS15000	COG3409	Peptidoglycan-binding domain 1 protein
APZ19_RS15015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APZ19_RS15020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APZ19_RS15030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APZ19_RS15035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APZ19_RS15040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APZ19_RS15045	COG1610	YqeY-like protein
APZ19_RS15050	COG0358	DNA primase activity
APZ19_RS15085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS15085	COG2213	PTS system mannitol-specific
APZ19_RS15095	COG3722	fumarate hydratase activity
APZ19_RS15100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APZ19_RS15105	COG5002	protein histidine kinase activity
APZ19_RS15125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APZ19_RS15130	COG1349	DNA-binding transcription factor activity
APZ19_RS15140	COG0469	pyruvate kinase activity
APZ19_RS15160	COG0028	Belongs to the TPP enzyme family
APZ19_RS15165	COG1022	Amp-dependent synthetase and ligase
APZ19_RS15170	COG0583	DNA-binding transcription factor activity
APZ19_RS15200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APZ19_RS15205	COG0473	3-isopropylmalate dehydrogenase activity
APZ19_RS15225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APZ19_RS15230	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APZ19_RS15235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APZ19_RS15240	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APZ19_RS15265	COG3610	response to peptide
APZ19_RS15270	COG2966	Psort location CytoplasmicMembrane, score
APZ19_RS15285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APZ19_RS15290	COG0142	geranyltranstransferase activity
APZ19_RS15315	COG2358	TRAP transporter, solute receptor (TAXI family
APZ19_RS15330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APZ19_RS15335	COG1178	ABC-type Fe3 transport system permease component
APZ19_RS15340	COG4143	(ABC) transporter
APZ19_RS15345	COG0163	prenyltransferase activity
APZ19_RS15350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APZ19_RS15360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APZ19_RS15375	COG2105	PFAM AIG2 family protein
APZ19_RS15385	COG0729	surface antigen
APZ19_RS15390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APZ19_RS15465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APZ19_RS15495	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APZ19_RS15510	COG1136	(ABC) transporter
APZ19_RS15530	COG0529	Catalyzes the synthesis of activated sulfate
APZ19_RS15535	COG0471	metal ion transport
APZ19_RS15535	COG3273	potassium ion transport
APZ19_RS15550	COG1648	precorrin-2 dehydrogenase activity
APZ19_RS15550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APZ19_RS15555	COG0737	Belongs to the 5'-nucleotidase family
APZ19_RS15570	COG0513	Belongs to the DEAD box helicase family
APZ19_RS15575	COG2153	protein acetylation
APZ19_RS15590	COG0545	Peptidyl-prolyl cis-trans isomerase
APZ19_RS15600	COG0203	ribosomal protein L17
APZ19_RS15605	COG0202	RNA polymerase activity
APZ19_RS15615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APZ19_RS15620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APZ19_RS15625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APZ19_RS15630	COG0201	protein transport
APZ19_RS15640	COG1841	ribosomal large subunit assembly
APZ19_RS15660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APZ19_RS15670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APZ19_RS15705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APZ19_RS15710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APZ19_RS15725	COG0088	Forms part of the polypeptide exit tunnel
APZ19_RS15740	COG0254	rRNA binding
APZ19_RS15750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APZ19_RS15755	COG1609	Transcriptional regulator
APZ19_RS15775	COG1575	Belongs to the MenA family. Type 1 subfamily
APZ19_RS15780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APZ19_RS15790	COG1494	fructose-1,6-bisphosphatase
APZ19_RS15820	COG0149	triose-phosphate isomerase activity
APZ19_RS15835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APZ19_RS15840	COG0517	IMP dehydrogenase activity
APZ19_RS15840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APZ19_RS15845	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APZ19_RS15850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APZ19_RS15855	COG1215	transferase activity, transferring glycosyl groups
APZ19_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS15965	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APZ19_RS15975	COG1560	Kdo2-lipid A biosynthetic process
APZ19_RS15990	COG1519	Transferase
APZ19_RS16005	COG0367	asparagine synthase
APZ19_RS16030	COG1083	cytidylyl-transferase
APZ19_RS16035	COG3642	lipopolysaccharide core region biosynthetic process
APZ19_RS16040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APZ19_RS16045	COG0859	PFAM glycosyl transferase family 9
APZ19_RS16050	COG0463	Glycosyl transferase, family 2
APZ19_RS16065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APZ19_RS16100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APZ19_RS16110	COG1560	Kdo2-lipid A biosynthetic process
APZ19_RS16115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APZ19_RS16120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APZ19_RS16125	COG1561	YicC-like family, N-terminal region
APZ19_RS16175	COG3645	SOS response
APZ19_RS16180	COG3645	SOS response
APZ19_RS16190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APZ19_RS16215	COG0745	RESPONSE REGULATOR receiver
APZ19_RS16240	COG4608	Belongs to the ABC transporter superfamily
APZ19_RS16245	COG0444	Belongs to the ABC transporter superfamily
APZ19_RS16250	COG0747	negative chemotaxis
APZ19_RS16255	COG4239	(ABC) transporter, permease
APZ19_RS16260	COG4174	ABC transporter (Permease)
APZ19_RS16285	COG0811	peptide transport
APZ19_RS16290	COG0848	biopolymer transport protein
APZ19_RS16305	COG0194	GDP metabolic process
APZ19_RS16310	COG1758	RNA polymerase activity
APZ19_RS16315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APZ19_RS16320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APZ19_RS16325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APZ19_RS16335	COG2233	PERMEase
APZ19_RS16350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ19_RS16360	COG2183	response to ionizing radiation
APZ19_RS16385	COG0494	nUDIX hydrolase
APZ19_RS16390	COG1218	3'(2'),5'-bisphosphate nucleotidase
APZ19_RS16400	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
APZ19_RS16405	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
APZ19_RS16410	COG3156	type II secretion system protein K
APZ19_RS16415	COG4795	General secretion pathway protein
APZ19_RS16420	COG2165	general secretion pathway protein
APZ19_RS16425	COG2165	general secretion pathway protein
APZ19_RS16430	COG2165	general secretion pathway protein
APZ19_RS16435	COG1459	type II secretion system
APZ19_RS16440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ19_RS16450	COG3031	protein transport across the cell outer membrane
APZ19_RS16455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APZ19_RS16475	COG0456	acetyltransferase
APZ19_RS16480	COG1490	D-aminoacyl-tRNA deacylase activity
APZ19_RS16500	COG1217	gtp-binding protein TYPA
APZ19_RS16505	COG0174	glutamine synthetase
APZ19_RS16515	COG3852	Histidine kinase
APZ19_RS16520	COG2204	response regulator
APZ19_RS16530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APZ19_RS16560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APZ19_RS16570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APZ19_RS16570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APZ19_RS16590	COG0084	hydrolase, TatD family'
APZ19_RS16595	COG0805	protein transport
APZ19_RS16600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APZ19_RS16615	COG3165	ubiquinone biosynthetic process from chorismate
APZ19_RS16625	COG1322	Protein conserved in bacteria
APZ19_RS16660	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APZ19_RS16705	COG2205	protein histidine kinase activity
APZ19_RS16705	COG0784	Response regulator, receiver
APZ19_RS16730	COG2081	HI0933 family
APZ19_RS16765	COG1528	Iron-storage protein
APZ19_RS16770	COG0589	response to stress
APZ19_RS16790	COG5002	protein histidine kinase activity
APZ19_RS16790	COG5001	Diguanylate cyclase
APZ19_RS16795	COG1522	sequence-specific DNA binding
APZ19_RS16805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APZ19_RS16815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APZ19_RS16820	COG0800	Aldolase
APZ19_RS16825	COG2610	gluconate transmembrane transporter activity
APZ19_RS16830	COG3265	gluconokinase activity
APZ19_RS16835	COG0129	dihydroxy-acid dehydratase activity
APZ19_RS16845	COG2076	Multidrug Resistance protein
APZ19_RS16850	COG0583	DNA-binding transcription factor activity
APZ19_RS16855	COG1609	Transcriptional regulator
APZ19_RS16890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APZ19_RS16895	COG0601	transmembrane transport
APZ19_RS16905	COG4172	Belongs to the ABC transporter superfamily
APZ19_RS16910	COG0546	phosphoglycolate phosphatase activity
APZ19_RS16950	COG1309	transcriptional regulator
APZ19_RS16955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS16960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ19_RS16970	COG2960	long-chain fatty acid transporting porin activity
APZ19_RS16975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APZ19_RS16980	COG0583	DNA-binding transcription factor activity
APZ19_RS17025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APZ19_RS17050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APZ19_RS17055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APZ19_RS17060	COG0551	DNA topoisomerase type I activity
APZ19_RS17070	COG0758	DNA mediated transformation
APZ19_RS17080	COG0242	peptide deformylase activity
APZ19_RS17090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APZ19_RS17090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APZ19_RS17095	COG0569	domain protein
APZ19_RS17100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APZ19_RS17110	COG1272	protein, Hemolysin III
APZ19_RS17115	COG4326	sporulation control protein
APZ19_RS17125	COG3084	Protein conserved in bacteria
APZ19_RS17135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APZ19_RS17140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APZ19_RS17145	COG0204	Acyl-transferase
APZ19_RS17155	COG0606	chelatase, subunit chli
APZ19_RS17165	COG3978	acetolactate synthase activity
APZ19_RS17170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APZ19_RS17175	COG0129	dihydroxy-acid dehydratase activity
APZ19_RS17185	COG3706	GGDEF domain
APZ19_RS17190	COG0583	DNA-binding transcription factor activity
APZ19_RS17195	COG2814	Major facilitator Superfamily
APZ19_RS17200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APZ19_RS17205	COG0765	amino acid transport
APZ19_RS17215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APZ19_RS17225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APZ19_RS17255	COG3312	ion transport
APZ19_RS17260	COG1475	DNA binding
APZ19_RS17265	COG1192	Involved in chromosome partitioning
APZ19_RS17280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APZ19_RS17310	COG1126	abc transporter atp-binding protein
APZ19_RS17390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APZ19_RS17395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APZ19_RS17405	COG1280	lysine exporter protein (LysE YggA)
APZ19_RS17415	COG0183	Belongs to the thiolase family
APZ19_RS17435	COG3005	denitrification pathway
APZ19_RS17455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APZ19_RS17460	COG3850	Histidine kinase
APZ19_RS17465	COG2197	response regulator
APZ19_RS17480	COG2195	Cleaves the N-terminal amino acid of tripeptides
APZ19_RS17500	COG0840	transmembrane signaling receptor activity
APZ19_RS17510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APZ19_RS17540	COG0545	Peptidyl-prolyl cis-trans isomerase
APZ19_RS17570	COG1278	Cold shock
APZ19_RS17575	COG3036	rescue of stalled ribosome
APZ19_RS17605	COG0577	efflux transmembrane transporter activity
APZ19_RS17605	COG1136	(ABC) transporter
APZ19_RS17635	COG1538	Outer membrane efflux protein
APZ19_RS17640	COG0784	Response regulator, receiver
APZ19_RS17640	COG2205	protein histidine kinase activity
APZ19_RS17670	COG0783	Belongs to the Dps family
APZ19_RS17680	COG1619	proteins homologs of microcin C7 resistance protein MccF
APZ19_RS17685	COG2133	pyrroloquinoline quinone binding
APZ19_RS17690	COG1454	alcohol dehydrogenase
APZ19_RS17695	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
APZ19_RS17715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APZ19_RS17720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APZ19_RS17725	COG3186	Phenylalanine-4-hydroxylase
APZ19_RS17760	COG3530	Putative quorum-sensing-regulated virulence factor
APZ19_RS17790	COG0523	cobalamin synthesis protein
APZ19_RS17800	COG0513	Belongs to the DEAD box helicase family
APZ19_RS17820	COG2200	EAL domain
APZ19_RS17825	COG1119	ATPase activity
APZ19_RS17880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APZ19_RS17895	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
APZ19_RS17900	COG0513	Belongs to the DEAD box helicase family
APZ19_RS17910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APZ19_RS17925	COG3278	Belongs to the heme-copper respiratory oxidase family
APZ19_RS17950	COG1024	Enoyl-CoA hydratase
APZ19_RS17955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APZ19_RS17960	COG1960	acyl-CoA dehydrogenase activity
APZ19_RS17970	COG0183	Belongs to the thiolase family
APZ19_RS17985	COG1024	Enoyl-CoA hydratase
APZ19_RS17990	COG1024	Enoyl-CoA hydratase
APZ19_RS18000	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS18005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APZ19_RS18010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APZ19_RS18015	COG1845	cytochrome c oxidase, subunit III
APZ19_RS18020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APZ19_RS18030	COG0446	pyridine nucleotide-disulphide oxidoreductase
APZ19_RS18030	COG1902	pentaerythritol trinitrate reductase activity
APZ19_RS18045	COG1012	belongs to the aldehyde dehydrogenase family
APZ19_RS18055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ19_RS18120	COG1126	abc transporter atp-binding protein
APZ19_RS18125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APZ19_RS18130	COG4215	(ABC) transporter
APZ19_RS18135	COG4160	amino acid transport
APZ19_RS18140	COG0840	transmembrane signaling receptor activity
APZ19_RS18160	COG3119	arylsulfatase activity
APZ19_RS18165	COG1053	succinate dehydrogenase
APZ19_RS18165	COG0431	NADPH-dependent FMN reductase
APZ19_RS18165	COG3976	FMN-binding domain protein
APZ19_RS18220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APZ19_RS18235	COG0443	Heat shock 70 kDa protein
APZ19_RS18240	COG2847	Copper chaperone PCu(A)C
APZ19_RS18270	COG0745	RESPONSE REGULATOR receiver
APZ19_RS18285	COG1785	Belongs to the alkaline phosphatase family
APZ19_RS18320	COG0814	amino acid
APZ19_RS18325	COG5002	protein histidine kinase activity
APZ19_RS18325	COG5001	Diguanylate cyclase
APZ19_RS18335	COG0243	molybdopterin cofactor binding
APZ19_RS18365	COG1116	anion transmembrane transporter activity
APZ19_RS18365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APZ19_RS18370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APZ19_RS18375	COG1116	anion transmembrane transporter activity
APZ19_RS18380	COG2146	nitrite reductase [NAD(P)H] activity
APZ19_RS18380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APZ19_RS18415	COG2165	general secretion pathway protein
APZ19_RS18425	COG2165	general secretion pathway protein
APZ19_RS18430	COG0745	RESPONSE REGULATOR receiver
APZ19_RS18435	COG2770	Histidine kinase
APZ19_RS18435	COG2205	protein histidine kinase activity
APZ19_RS18440	COG2165	general secretion pathway protein
APZ19_RS18460	COG1902	pentaerythritol trinitrate reductase activity
APZ19_RS18470	COG1475	DNA binding
APZ19_RS18525	COG2212	antiporter activity
APZ19_RS18530	COG1320	monovalent cation:proton antiporter activity
APZ19_RS18535	COG1294	oxidase, subunit
APZ19_RS18550	COG0583	DNA-binding transcription factor activity
APZ19_RS18560	COG0739	heme binding
APZ19_RS18595	COG0628	permease
APZ19_RS18630	COG3321	synthase
APZ19_RS18630	COG0604	alcohol dehydrogenase
APZ19_RS18635	COG1024	Enoyl-CoA hydratase
APZ19_RS18650	COG0662	Cupin 2, conserved barrel domain protein
APZ19_RS18650	COG2207	Transcriptional regulator
APZ19_RS18720	COG1132	(ABC) transporter
APZ19_RS18745	COG0583	DNA-binding transcription factor activity
APZ19_RS18750	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APZ19_RS18765	COG2814	Major facilitator Superfamily
APZ19_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS18790	COG1196	nuclear chromosome segregation
APZ19_RS18805	COG0509	glycine decarboxylation via glycine cleavage system
APZ19_RS18810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APZ19_RS18820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APZ19_RS18830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS18835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS18865	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APZ19_RS18865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS18865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS18870	COG1105	Belongs to the carbohydrate kinase PfkB family
APZ19_RS18875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS18875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS18880	COG1609	Transcriptional regulator
APZ19_RS18895	COG2199	diguanylate cyclase activity
APZ19_RS18895	COG2203	Gaf domain
APZ19_RS18895	COG2200	EAL domain
APZ19_RS18900	COG0765	amino acid transport
APZ19_RS18905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APZ19_RS18965	COG5532	Uncharacterized conserved protein (DUF2303)
APZ19_RS18990	COG1484	DNA-dependent DNA replication
APZ19_RS19250	COG0765	amino acid transport
APZ19_RS19255	COG1126	abc transporter atp-binding protein
APZ19_RS19265	COG1979	alcohol dehydrogenase
APZ19_RS19270	COG2207	Transcriptional regulator
APZ19_RS19280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APZ19_RS19290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS19305	COG3437	response regulator, receiver
APZ19_RS19305	COG0784	Response regulator, receiver
APZ19_RS19310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APZ19_RS19315	COG0840	transmembrane signaling receptor activity
APZ19_RS19325	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
APZ19_RS19330	COG0513	Belongs to the DEAD box helicase family
APZ19_RS19335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APZ19_RS19350	COG3038	cytochrome b561
APZ19_RS19360	COG2116	formate transmembrane transporter activity
APZ19_RS19365	COG0583	DNA-binding transcription factor activity
APZ19_RS19375	COG3593	DNA synthesis involved in DNA repair
APZ19_RS19380	COG0737	Belongs to the 5'-nucleotidase family
APZ19_RS19400	COG0646	methionine synthase
APZ19_RS19400	COG1410	methionine synthase
APZ19_RS19415	COG2267	carboxylic ester hydrolase activity
APZ19_RS19435	COG2050	protein possibly involved in aromatic compounds catabolism
APZ19_RS19470	COG0484	heat shock protein binding
APZ19_RS19480	COG5001	Diguanylate cyclase
APZ19_RS19480	COG3300	MHYT domain
APZ19_RS19485	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APZ19_RS19495	COG4181	ATPase activity
APZ19_RS19500	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APZ19_RS19510	COG1984	allophanate hydrolase subunit 2
APZ19_RS19515	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APZ19_RS19525	COG5002	protein histidine kinase activity
APZ19_RS19525	COG3447	MASE1 domain protein
APZ19_RS19525	COG5001	Diguanylate cyclase
APZ19_RS19530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APZ19_RS19545	COG0583	DNA-binding transcription factor activity
APZ19_RS19550	COG0045	succinate-CoA ligase (ADP-forming) activity
APZ19_RS19550	COG1042	CoA-binding domain protein
APZ19_RS19550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APZ19_RS19570	COG0023	Translation Initiation Factor
APZ19_RS19590	COG3140	Belongs to the UPF0181 family
APZ19_RS19615	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APZ19_RS19620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APZ19_RS19660	COG4251	negative regulation of phosphorylation
APZ19_RS19660	COG2203	Gaf domain
APZ19_RS19660	COG5001	Diguanylate cyclase
APZ19_RS19660	COG3706	GGDEF domain
APZ19_RS19670	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APZ19_RS19675	COG4149	molybdate abc transporter
APZ19_RS19680	COG0725	ABC transporter, periplasmic molybdate-binding protein
APZ19_RS19690	COG3111	PFAM Bacterial OB fold (BOF) protein
APZ19_RS19715	COG0534	Mate efflux family protein
APZ19_RS19720	COG0602	queuosine metabolic process
APZ19_RS19725	COG1328	CTP reductase activity
APZ19_RS19800	COG2197	response regulator
APZ19_RS19805	COG3851	Histidine kinase
APZ19_RS19810	COG2271	Major facilitator Superfamily
APZ19_RS19815	COG1482	cell wall glycoprotein biosynthetic process
APZ19_RS19825	COG0628	permease
APZ19_RS19835	COG1566	PFAM secretion protein HlyD family protein
APZ19_RS19865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APZ19_RS19870	COG3118	belongs to the thioredoxin family
APZ19_RS19880	COG0745	RESPONSE REGULATOR receiver
APZ19_RS19880	COG2205	protein histidine kinase activity
APZ19_RS19880	COG3292	Two component regulator propeller
APZ19_RS19885	COG0534	Mate efflux family protein
APZ19_RS19905	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APZ19_RS19925	COG2116	formate transmembrane transporter activity
APZ19_RS19935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APZ19_RS19945	COG2199	diguanylate cyclase activity
APZ19_RS20020	COG0277	FAD linked oxidase domain protein
APZ19_RS20025	COG0583	DNA-binding transcription factor activity
APZ19_RS20030	COG1472	Belongs to the glycosyl hydrolase 3 family
APZ19_RS20040	COG2425	protein containing a von Willebrand factor type A (vWA) domain
APZ19_RS20055	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APZ19_RS20065	COG1288	antiporter activity
APZ19_RS20075	COG2814	Major facilitator Superfamily
APZ19_RS20085	COG3040	lipid binding
APZ19_RS20115	COG3469	chitinase activity
APZ19_RS20125	COG0419	ATPase involved in DNA repair
APZ19_RS20130	COG0420	3'-5' exonuclease activity
APZ19_RS20210	COG0631	protein serine/threonine phosphatase activity
APZ19_RS20245	COG0515	serine threonine protein kinase
APZ19_RS20245	COG2815	serine threonine protein kinase
APZ19_RS20285	COG0346	lactoylglutathione lyase activity
APZ19_RS20290	COG1902	pentaerythritol trinitrate reductase activity
APZ19_RS20300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APZ19_RS20300	COG2755	lipolytic protein G-D-S-L family
APZ19_RS20310	COG5642	Protein of unknown function (DUF2384)
APZ19_RS20325	COG1234	tRNA 3'-trailer cleavage
APZ19_RS20330	COG2067	long-chain fatty acid transport protein
APZ19_RS20375	COG0671	phosphoesterase, PA-phosphatase related
APZ19_RS20390	COG2962	Rard protein
APZ19_RS20400	COG2165	general secretion pathway protein
APZ19_RS20405	COG0784	Response regulator, receiver
APZ19_RS20405	COG0835	chemotaxis
APZ19_RS20410	COG0778	Nitroreductase
APZ19_RS20420	COG2197	response regulator
APZ19_RS20430	COG3706	GGDEF domain
APZ19_RS20435	COG2197	response regulator
APZ19_RS20440	COG3300	MHYT domain
APZ19_RS20440	COG5001	Diguanylate cyclase
APZ19_RS20445	COG0784	Response regulator, receiver
APZ19_RS20445	COG2205	protein histidine kinase activity
APZ19_RS20460	COG4771	TonB-dependent receptor
APZ19_RS20515	COG1522	sequence-specific DNA binding
APZ19_RS20550	COG0515	serine threonine protein kinase
APZ19_RS20575	COG3501	Rhs element vgr protein
APZ19_RS20590	COG2204	response regulator
APZ19_RS20595	COG2885	chlorophyll binding
APZ19_RS20630	COG0739	heme binding
APZ19_RS20635	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
APZ19_RS20665	COG3069	C4-dicarboxylate transmembrane transporter activity
APZ19_RS20670	COG1704	LemA family
APZ19_RS20675	COG0501	Belongs to the peptidase M48B family
APZ19_RS20705	COG0641	radical SAM
APZ19_RS20725	COG3111	PFAM Bacterial OB fold (BOF) protein
APZ19_RS20730	COG1597	lipid kinase activity
APZ19_RS20745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APZ19_RS20755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APZ19_RS20815	COG0714	Associated with various cellular activities
APZ19_RS20820	COG0641	radical SAM
APZ19_RS20825	COG3119	arylsulfatase activity
APZ19_RS20830	COG0583	DNA-binding transcription factor activity
APZ19_RS20840	COG3119	arylsulfatase activity
APZ19_RS20845	COG3119	arylsulfatase activity
APZ19_RS20850	COG3119	arylsulfatase activity
APZ19_RS20880	COG0784	Response regulator, receiver
APZ19_RS20880	COG2198	Histidine kinase
APZ19_RS20880	COG2205	protein histidine kinase activity
APZ19_RS20885	COG1879	ABC-type sugar transport system periplasmic component
APZ19_RS20895	COG0210	DNA helicase
APZ19_RS20900	COG1289	transmembrane transporter activity
APZ19_RS20930	COG4206	TonB-dependent receptor
APZ19_RS20940	COG0789	Transcriptional regulator
APZ19_RS20945	COG4604	ABC transporter, ATP-binding protein
APZ19_RS20950	COG4605	iron ion homeostasis
APZ19_RS20955	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APZ19_RS20960	COG4607	ABC-type enterochelin transport system periplasmic component
APZ19_RS20975	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APZ19_RS20990	COG1609	Transcriptional regulator
APZ19_RS20995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS21005	COG1172	Belongs to the binding-protein-dependent transport system permease family
APZ19_RS21010	COG1129	ABC transporter
APZ19_RS21020	COG5001	Diguanylate cyclase
APZ19_RS21025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APZ19_RS21030	COG1794	racemase activity, acting on amino acids and derivatives
APZ19_RS21035	COG1051	belongs to the nudix hydrolase family
APZ19_RS21060	COG0586	Pfam SNARE associated Golgi protein
APZ19_RS21080	COG0745	RESPONSE REGULATOR receiver
APZ19_RS21125	COG0583	DNA-binding transcription factor activity
APZ19_RS21135	COG2205	protein histidine kinase activity
APZ19_RS21135	COG0784	Response regulator, receiver
APZ19_RS21145	COG2205	protein histidine kinase activity
APZ19_RS21145	COG0784	Response regulator, receiver
APZ19_RS21150	COG2199	diguanylate cyclase activity
APZ19_RS21150	COG2200	EAL domain
APZ19_RS21150	COG2203	Gaf domain
APZ19_RS21180	COG0330	HflC and HflK could
APZ19_RS21245	COG0529	Catalyzes the synthesis of activated sulfate
APZ19_RS21250	COG3273	potassium ion transport
APZ19_RS21250	COG0471	metal ion transport
APZ19_RS21260	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APZ19_RS21275	COG0438	transferase activity, transferring glycosyl groups
APZ19_RS21295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APZ19_RS21300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APZ19_RS21305	COG2895	sulfate adenylyltransferase (ATP) activity
APZ19_RS21310	COG0175	sulfate reduction
APZ19_RS21320	COG1596	polysaccharide export
APZ19_RS21325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APZ19_RS21330	COG4175	Glycine betaine
APZ19_RS21330	COG0517	IMP dehydrogenase activity
APZ19_RS21335	COG4176	ABC-type proline glycine betaine transport system permease component
APZ19_RS21370	COG3706	GGDEF domain
APZ19_RS21380	COG0402	S-adenosylhomocysteine deaminase activity
APZ19_RS21415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APZ19_RS21415	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APZ19_RS21430	COG4989	oxidoreductase activity
APZ19_RS21455	COG1914	H( )-stimulated, divalent metal cation uptake system
APZ19_RS21490	COG2897	thiosulfate sulfurtransferase activity
APZ19_RS21515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APZ19_RS21520	COG0840	transmembrane signaling receptor activity
APZ19_RS21525	COG2814	Major facilitator Superfamily
APZ19_RS21530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APZ19_RS21545	COG1612	heme a metabolic process
APZ19_RS21565	COG1845	cytochrome c oxidase, subunit III
APZ19_RS21570	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
APZ19_RS21585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APZ19_RS21595	COG1280	lysine exporter protein (LysE YggA)
APZ19_RS21615	COG0179	Fumarylacetoacetate (FAA) hydrolase
APZ19_RS21630	COG0697	spore germination
APZ19_RS21650	COG2814	Major facilitator Superfamily
APZ19_RS21655	COG0583	DNA-binding transcription factor activity
APZ19_RS21670	COG4774	siderophore transport
APZ19_RS21685	COG1120	ATPase activity
APZ19_RS21690	COG5001	Diguanylate cyclase
APZ19_RS21695	COG0739	heme binding
APZ19_RS21720	COG3314	Sporulation integral membrane protein YlbJ
APZ19_RS21735	COG0814	amino acid
APZ19_RS21750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
APZ19_RS21755	COG1072	(Pantothenic acid kinase))
APZ19_RS21765	COG1063	alcohol dehydrogenase
APZ19_RS21770	COG2213	PTS system mannitol-specific
APZ19_RS21775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS21780	COG2188	Transcriptional regulator
APZ19_RS21785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS21785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS21785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS21790	COG0383	alpha-mannosidase activity
APZ19_RS21795	COG1482	cell wall glycoprotein biosynthetic process
APZ19_RS21805	COG4989	oxidoreductase activity
APZ19_RS21825	COG1733	regulation of RNA biosynthetic process
APZ19_RS21840	COG0798	PFAM Bile acid sodium symporter
APZ19_RS21855	COG1881	PFAM PEBP family protein
APZ19_RS21865	COG0251	oxidation-reduction process
APZ19_RS21870	COG2706	6-phosphogluconolactonase activity
APZ19_RS21880	COG0800	Aldolase
APZ19_RS21885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS21890	COG4145	pantothenate transmembrane transporter activity
APZ19_RS21900	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APZ19_RS21925	COG1131	(ABC) transporter
APZ19_RS21930	COG0842	Transport permease protein
APZ19_RS21945	COG3383	formate dehydrogenase (NAD+) activity
APZ19_RS21965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ19_RS21990	COG3321	synthase
APZ19_RS21990	COG0604	alcohol dehydrogenase
APZ19_RS21990	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS22010	COG0494	nUDIX hydrolase
APZ19_RS22025	COG1858	cytochrome C peroxidase
APZ19_RS22035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APZ19_RS22045	COG2067	long-chain fatty acid transport protein
APZ19_RS22055	COG1505	serine-type exopeptidase activity
APZ19_RS22060	COG0488	(ABC) transporter
APZ19_RS22065	COG1720	tRNA m6t6A37 methyltransferase activity
APZ19_RS22085	COG0589	response to stress
APZ19_RS22110	COG1175	transmembrane transport
APZ19_RS22115	COG0395	ABC-type sugar transport system, permease component
APZ19_RS22120	COG3842	ATPase activity
APZ19_RS22160	COG0523	cobalamin synthesis protein
APZ19_RS22170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APZ19_RS22180	COG4667	esterase of the alpha-beta hydrolase superfamily
APZ19_RS22185	COG1741	Belongs to the pirin family
APZ19_RS22190	COG1278	Cold shock
APZ19_RS22205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APZ19_RS22210	COG3706	GGDEF domain
APZ19_RS22235	COG2226	methyltransferase
APZ19_RS22245	COG3706	GGDEF domain
APZ19_RS22250	COG1686	Belongs to the peptidase S11 family
APZ19_RS22255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ19_RS22260	COG2249	NAD(P)H dehydrogenase (quinone) activity
APZ19_RS22270	COG0625	glutathione transferase activity
APZ19_RS22280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APZ19_RS22290	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS22315	COG3746	phosphate-selective porin O and P
APZ19_RS22330	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS22340	COG0583	DNA-binding transcription factor activity
APZ19_RS22345	COG2207	Transcriptional regulator
APZ19_RS22345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APZ19_RS22350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APZ19_RS22380	COG0513	Belongs to the DEAD box helicase family
APZ19_RS22390	COG0583	DNA-binding transcription factor activity
APZ19_RS22410	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS22415	COG2814	Major facilitator Superfamily
APZ19_RS22425	COG1902	pentaerythritol trinitrate reductase activity
APZ19_RS22440	COG3122	Protein conserved in bacteria
APZ19_RS22445	COG0583	DNA-binding transcription factor activity
APZ19_RS22465	COG0583	DNA-binding transcription factor activity
APZ19_RS22470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APZ19_RS22485	COG0252	asparaginase activity
APZ19_RS22495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APZ19_RS22495	COG0574	Belongs to the PEP-utilizing enzyme family
APZ19_RS22505	COG2197	response regulator
APZ19_RS22510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APZ19_RS22560	COG0583	DNA-binding transcription factor activity
APZ19_RS22565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS22580	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APZ19_RS22585	COG0786	glutamate:sodium symporter activity
APZ19_RS22615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ19_RS22620	COG0318	PFAM AMP-dependent synthetase and ligase
APZ19_RS22640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ19_RS22650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APZ19_RS22660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APZ19_RS22705	COG1621	beta-fructofuranosidase activity
APZ19_RS22710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS22710	COG1263	PTS System
APZ19_RS22715	COG2188	Transcriptional regulator
APZ19_RS22730	COG4948	Mandelate Racemase Muconate Lactonizing
APZ19_RS22770	COG1342	Belongs to the UPF0251 family
APZ19_RS22780	COG4176	ABC-type proline glycine betaine transport system permease component
APZ19_RS22785	COG3448	diguanylate cyclase activity
APZ19_RS22785	COG4175	Glycine betaine
APZ19_RS22800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APZ19_RS22805	COG0583	DNA-binding transcription factor activity
APZ19_RS22855	COG1335	isochorismatase
APZ19_RS22870	COG0753	catalase activity
APZ19_RS22890	COG1482	cell wall glycoprotein biosynthetic process
APZ19_RS22895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APZ19_RS22900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS22900	COG1263	PTS System
APZ19_RS22905	COG1609	Transcriptional regulator
APZ19_RS22910	COG1349	DNA-binding transcription factor activity
APZ19_RS22915	COG0346	lactoylglutathione lyase activity
APZ19_RS22920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APZ19_RS22920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APZ19_RS22930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS22935	COG3537	Alpha-1,2-mannosidase
APZ19_RS22940	COG3537	Alpha-1,2-mannosidase
APZ19_RS22950	COG3537	Alpha-1,2-mannosidase
APZ19_RS22955	COG3537	Alpha-1,2-mannosidase
APZ19_RS22960	COG0737	Belongs to the 5'-nucleotidase family
APZ19_RS22990	COG1280	lysine exporter protein (LysE YggA)
APZ19_RS22995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APZ19_RS23010	COG3226	Transcriptional regulator
APZ19_RS23025	COG0583	DNA-binding transcription factor activity
APZ19_RS23055	COG0431	NADPH-dependent FMN reductase
APZ19_RS23060	COG0583	DNA-binding transcription factor activity
APZ19_RS23065	COG4628	conserved protein (DUF2132)
APZ19_RS23070	COG0488	(ABC) transporter
APZ19_RS23085	COG0346	lactoylglutathione lyase activity
APZ19_RS23090	COG0384	phenazine biosynthesis protein PhzF
APZ19_RS23105	COG3220	belongs to the UPF0276 family
APZ19_RS23120	COG1271	oxidase subunit
APZ19_RS23125	COG1294	oxidase, subunit
APZ19_RS23170	COG2207	Transcriptional regulator
APZ19_RS23180	COG1882	Formate acetyltransferase
APZ19_RS23185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APZ19_RS23190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APZ19_RS23205	COG2205	protein histidine kinase activity
APZ19_RS23210	COG0745	RESPONSE REGULATOR receiver
APZ19_RS23220	COG0454	-acetyltransferase
APZ19_RS23225	COG0148	phosphopyruvate hydratase activity
APZ19_RS23235	COG2814	Major facilitator Superfamily
APZ19_RS23250	COG2988	succinylglutamate desuccinylase activity
APZ19_RS23290	COG0628	permease
APZ19_RS23295	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
APZ19_RS23310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APZ19_RS23320	COG4628	conserved protein (DUF2132)
APZ19_RS23325	COG0583	DNA-binding transcription factor activity
APZ19_RS23350	COG1686	Belongs to the peptidase S11 family
APZ19_RS23370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APZ19_RS23375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APZ19_RS23400	COG0415	Belongs to the DNA photolyase family
APZ19_RS23405	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APZ19_RS23415	COG4667	esterase of the alpha-beta hydrolase superfamily
APZ19_RS23420	COG2095	MarC family integral membrane protein
APZ19_RS23455	COG0583	DNA-binding transcription factor activity
APZ19_RS23460	COG2814	Major facilitator Superfamily
APZ19_RS23490	COG1301	dicarboxylic acid transport
APZ19_RS23495	COG3339	Conserved Protein
APZ19_RS23500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APZ19_RS23505	COG0700	Nucleoside recognition
APZ19_RS23510	COG3366	ferrous iron transmembrane transporter activity
APZ19_RS23525	COG0366	Alpha amylase catalytic
APZ19_RS23535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APZ19_RS23540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APZ19_RS23545	COG1640	4-alpha-glucanotransferase
APZ19_RS23550	COG0058	SHG alpha-glucan phosphorylase activity
APZ19_RS23570	COG1999	signal sequence binding
APZ19_RS23585	COG1162	GTPase activity
APZ19_RS23590	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APZ19_RS23595	COG0673	inositol 2-dehydrogenase activity
APZ19_RS23620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS23625	COG0673	inositol 2-dehydrogenase activity
APZ19_RS23630	COG3962	Belongs to the TPP enzyme family
APZ19_RS23640	COG2814	Major facilitator Superfamily
APZ19_RS23640	COG0477	Major facilitator Superfamily
APZ19_RS23660	COG0183	Belongs to the thiolase family
APZ19_RS23665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APZ19_RS23690	COG0531	amino acid
APZ19_RS23695	COG1982	Orn Lys Arg decarboxylase major
APZ19_RS23715	COG2356	endonuclease I
APZ19_RS23745	COG2199	diguanylate cyclase activity
APZ19_RS23745	COG2203	Gaf domain
APZ19_RS23770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APZ19_RS23785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS23785	COG1263	PTS System
APZ19_RS23790	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS23795	COG1760	l-serine dehydratase
APZ19_RS23820	COG1609	Transcriptional regulator
APZ19_RS23830	COG2814	Major facilitator Superfamily
APZ19_RS23835	COG3214	Protein conserved in bacteria
APZ19_RS23845	COG4771	TonB-dependent receptor
APZ19_RS23850	COG0583	DNA-binding transcription factor activity
APZ19_RS23855	COG4607	ABC-type enterochelin transport system periplasmic component
APZ19_RS23860	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APZ19_RS23865	COG4605	iron ion homeostasis
APZ19_RS23870	COG4604	ABC transporter, ATP-binding protein
APZ19_RS23895	COG0739	heme binding
APZ19_RS23910	COG0800	Aldolase
APZ19_RS23915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS23920	COG2190	(PTS) system
APZ19_RS23920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS23920	COG1263	PTS System
APZ19_RS23930	COG2188	Transcriptional regulator
APZ19_RS23940	COG1621	beta-fructofuranosidase activity
APZ19_RS23950	COG3842	ATPase activity
APZ19_RS23955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APZ19_RS23960	COG1554	hydrolase, family 65, central catalytic
APZ19_RS23965	COG0395	ABC-type sugar transport system, permease component
APZ19_RS23970	COG1175	transmembrane transport
APZ19_RS24000	COG3121	Chaperone
APZ19_RS24005	COG3188	usher protein
APZ19_RS24035	COG0612	Peptidase, M16
APZ19_RS24040	COG0840	transmembrane signaling receptor activity
APZ19_RS24055	COG0826	peptidase U32
APZ19_RS24070	COG0667	Aldo Keto reductase
APZ19_RS24080	COG2249	NAD(P)H dehydrogenase (quinone) activity
APZ19_RS24085	COG0666	response to abiotic stimulus
APZ19_RS24090	COG0583	DNA-binding transcription factor activity
APZ19_RS24100	COG1136	(ABC) transporter
APZ19_RS24105	COG0577	efflux transmembrane transporter activity
APZ19_RS24150	COG1764	response to oxidative stress
APZ19_RS24155	COG1846	Transcriptional regulator
APZ19_RS24165	COG3634	alkyl hydroperoxide reductase activity
APZ19_RS24185	COG2188	Transcriptional regulator
APZ19_RS24190	COG2271	Major facilitator Superfamily
APZ19_RS24195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS24200	COG1397	ADP-ribosylglycohydrolase
APZ19_RS24205	COG2211	Major facilitator Superfamily
APZ19_RS24225	COG0346	lactoylglutathione lyase activity
APZ19_RS24230	COG0840	transmembrane signaling receptor activity
APZ19_RS24240	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APZ19_RS24250	COG1522	sequence-specific DNA binding
APZ19_RS24265	COG2258	MOSC domain
APZ19_RS24270	COG1609	Transcriptional regulator
APZ19_RS24275	COG1757	Na H antiporter
APZ19_RS24280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APZ19_RS24285	COG0513	Belongs to the DEAD box helicase family
APZ19_RS24305	COG1595	DNA-templated transcription, initiation
APZ19_RS24315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APZ19_RS24320	COG1312	Catalyzes the dehydration of D-mannonate
APZ19_RS24325	COG2186	Transcriptional regulator
APZ19_RS24335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APZ19_RS24345	COG0246	Mannitol dehydrogenase
APZ19_RS24350	COG1904	glucuronate isomerase
APZ19_RS24355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APZ19_RS24360	COG0800	Aldolase
APZ19_RS24375	COG0549	Belongs to the carbamate kinase family
APZ19_RS24380	COG0531	amino acid
APZ19_RS24385	COG2957	Belongs to the agmatine deiminase family
APZ19_RS24410	COG1132	(ABC) transporter
APZ19_RS24435	COG0406	alpha-ribazole phosphatase activity
APZ19_RS24530	COG4166	transmembrane transport
APZ19_RS24545	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APZ19_RS24550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APZ19_RS24550	COG1263	PTS System
APZ19_RS24555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APZ19_RS24580	COG1444	tRNA N-acetyltransferase activity
APZ19_RS24605	COG4608	Belongs to the ABC transporter superfamily
APZ19_RS24610	COG0444	Belongs to the ABC transporter superfamily
APZ19_RS24620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APZ19_RS24620	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
APZ19_RS24645	COG0772	Belongs to the SEDS family
APZ19_RS24655	COG1566	PFAM secretion protein HlyD family protein
APZ19_RS24660	COG0583	DNA-binding transcription factor activity
APZ19_RS24670	COG1136	(ABC) transporter
APZ19_RS24690	COG3275	phosphorelay sensor kinase activity
APZ19_RS24695	COG3279	Response regulator of the LytR AlgR family
APZ19_RS24705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APZ19_RS24730	COG0786	glutamate:sodium symporter activity
APZ19_RS24745	COG1131	(ABC) transporter
APZ19_RS24750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APZ19_RS24755	COG0786	glutamate:sodium symporter activity
APZ19_RS24775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APZ19_RS24790	COG0829	nickel cation binding
APZ19_RS24795	COG0831	urea catabolic process
APZ19_RS24800	COG0832	Belongs to the urease beta subunit family
APZ19_RS24805	COG0804	urea catabolic process
APZ19_RS24810	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APZ19_RS24815	COG0830	nickel cation binding
APZ19_RS24820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APZ19_RS24830	COG2207	Transcriptional regulator
APZ19_RS24835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APZ19_RS24845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APZ19_RS24855	COG0251	oxidation-reduction process
APZ19_RS24860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APZ19_RS24905	COG0561	phosphatase activity
APZ19_RS24910	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APZ19_RS24915	COG3623	hexulose-6-phosphate isomerase
APZ19_RS24955	COG1741	Belongs to the pirin family
APZ19_RS24960	COG2259	Doxx family
APZ19_RS24970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APZ19_RS24975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APZ19_RS24985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APZ19_RS25105	COG5001	Diguanylate cyclase
APZ19_RS25110	COG4580	involved in the transport of maltose and maltodextrins
APZ19_RS25115	COG1609	Transcriptional regulator
APZ19_RS25130	COG0395	ABC-type sugar transport system, permease component
APZ19_RS25135	COG2723	6-phospho-beta-galactosidase activity
APZ19_RS25140	COG3842	ATPase activity
APZ19_RS25145	COG1609	Transcriptional regulator
APZ19_RS25150	COG0534	Mate efflux family protein
APZ19_RS25155	COG0564	pseudouridine synthase activity
APZ19_RS25170	COG0561	phosphatase activity
APZ19_RS25180	COG2199	diguanylate cyclase activity
APZ19_RS25190	COG3152	Membrane
APZ19_RS25205	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APZ19_RS25210	COG2162	N-hydroxyarylamine O-acetyltransferase activity
APZ19_RS25225	COG0583	DNA-binding transcription factor activity
APZ19_RS25270	COG2076	Multidrug Resistance protein
APZ19_RS25285	COG1357	PFAM Pentapeptide repeats (8 copies)
APZ19_RS25290	COG3047	cAMP biosynthetic process
APZ19_RS25295	COG2358	TRAP transporter, solute receptor (TAXI family
APZ19_RS25310	COG2814	Major facilitator Superfamily
APZ19_RS25330	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
APZ19_RS25330	COG3408	Glycogen debranching enzyme
APZ19_RS25360	COG0583	DNA-binding transcription factor activity
APZ19_RS25400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APZ19_RS25435	COG1228	amidohydrolase
APZ19_RS25445	COG3835	regulator
APZ19_RS25450	COG1929	Belongs to the glycerate kinase type-1 family
APZ19_RS25455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APZ19_RS25500	COG0456	acetyltransferase
APZ19_RS25520	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS25530	COG3005	denitrification pathway
APZ19_RS25535	COG0243	molybdopterin cofactor binding
APZ19_RS25540	COG5002	protein histidine kinase activity
APZ19_RS25550	COG0671	phosphoesterase, PA-phosphatase related
APZ19_RS25575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APZ19_RS25580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APZ19_RS25585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APZ19_RS25590	COG1116	anion transmembrane transporter activity
APZ19_RS25595	COG0351	phosphomethylpyrimidine kinase
APZ19_RS25600	COG0312	modulator of DNA gyrase
APZ19_RS25605	COG0312	modulator of DNA gyrase
APZ19_RS25670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APZ19_RS25680	COG0584	glycerophosphoryl diester phosphodiesterase
APZ19_RS25685	COG0039	L-malate dehydrogenase activity
APZ19_RS25690	COG0745	RESPONSE REGULATOR receiver
APZ19_RS25710	COG0811	peptide transport
APZ19_RS25715	COG0811	peptide transport
APZ19_RS25720	COG0848	biopolymer transport protein
APZ19_RS25765	COG0803	Belongs to the bacterial solute-binding protein 9 family
APZ19_RS25770	COG1121	(ABC) transporter
APZ19_RS25775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APZ19_RS25790	COG1770	oligopeptidase
APZ19_RS25795	COG2814	Major facilitator Superfamily
APZ19_RS25800	COG0010	Belongs to the arginase family
APZ19_RS25805	COG1166	arginine decarboxylase activity
APZ19_RS25815	COG4067	protein conserved in archaea
APZ19_RS25815	COG0189	ligase activity
APZ19_RS25820	COG0189	ligase activity
APZ19_RS25840	COG0583	DNA-binding transcription factor activity
APZ19_RS25880	COG3706	GGDEF domain
APZ19_RS25905	COG0579	oxidoreductase
APZ19_RS25910	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APZ19_RS25925	COG3033	Beta-eliminating lyase
APZ19_RS25940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APZ19_RS25945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APZ19_RS25965	COG3706	GGDEF domain
APZ19_RS25980	COG3706	GGDEF domain
APZ19_RS25985	COG0415	Belongs to the DNA photolyase family
APZ19_RS25990	COG3046	protein related to deoxyribodipyrimidine photolyase
APZ19_RS26005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APZ19_RS26005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APZ19_RS26010	COG1765	OsmC-like protein
APZ19_RS26050	COG1011	Hydrolase
APZ19_RS26085	COG3240	lipase activity
APZ19_RS26115	COG1609	Transcriptional regulator
APZ19_RS26125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APZ19_RS26135	COG1840	ABC-type Fe3 transport system, periplasmic component
APZ19_RS26140	COG3842	ATPase activity
APZ19_RS26165	COG2990	Protein conserved in bacteria
APZ19_RS26175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APZ19_RS26180	COG2866	Carboxypeptidase
APZ19_RS26190	COG0583	DNA-binding transcription factor activity
APZ19_RS26215	COG3104	oligopeptide transport
APZ19_RS26220	COG1760	l-serine dehydratase
APZ19_RS26245	COG1388	LysM domain
APZ19_RS26245	COG0741	lytic transglycosylase activity
APZ19_RS26265	COG1815	bacterial-type flagellum-dependent cell motility
APZ19_RS26270	COG1558	bacterial-type flagellum-dependent cell motility
APZ19_RS26275	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APZ19_RS26280	COG1749	Flagellar hook protein flgE
APZ19_RS26285	COG4787	bacterial-type flagellum-dependent cell motility
APZ19_RS26290	COG4786	Flagellar basal body rod
APZ19_RS26295	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APZ19_RS26300	COG1706	bacterial-type flagellum-dependent cell motility
APZ19_RS26310	COG1256	bacterial-type flagellum assembly
APZ19_RS26310	COG4786	Flagellar basal body rod
APZ19_RS26315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ19_RS26340	COG0583	DNA-binding transcription factor activity
APZ19_RS26360	COG1253	flavin adenine dinucleotide binding
APZ19_RS26365	COG3710	Transcriptional regulator
APZ19_RS26380	COG2226	methyltransferase
APZ19_RS26435	COG1360	Flagellar Motor Protein
APZ19_RS26440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APZ19_RS26445	COG1191	sigma factor activity
APZ19_RS26450	COG1580	Controls the rotational direction of flagella during chemotaxis
APZ19_RS26465	COG1516	flagellar protein fliS
APZ19_RS26470	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APZ19_RS26480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APZ19_RS26495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APZ19_RS26505	COG1987	bacterial-type flagellum assembly
APZ19_RS26565	COG5001	Diguanylate cyclase
APZ19_RS26565	COG5002	protein histidine kinase activity
APZ19_RS26580	COG0697	spore germination
APZ19_RS26625	COG0346	lactoylglutathione lyase activity
APZ19_RS26650	COG0745	RESPONSE REGULATOR receiver
APZ19_RS26675	COG0156	8-amino-7-oxononanoate synthase activity
APZ19_RS26680	COG1063	alcohol dehydrogenase
APZ19_RS26740	COG0668	transmembrane transport
APZ19_RS26755	COG1304	FMN binding
APZ19_RS26760	COG1620	l-lactate permease
APZ19_RS26765	COG0583	DNA-binding transcription factor activity
APZ19_RS26770	COG1505	serine-type exopeptidase activity
APZ19_RS26775	COG4172	Belongs to the ABC transporter superfamily
APZ19_RS26785	COG1067	ATP-dependent peptidase activity
APZ19_RS26795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APZ19_RS26815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APZ19_RS26820	COG0437	4 iron, 4 sulfur cluster binding
APZ19_RS26825	COG0348	domain, Protein
APZ19_RS26840	COG0640	Transcriptional regulator
APZ19_RS26850	COG2731	YhcH YjgK YiaL family protein
APZ19_RS26865	COG1122	ATPase activity
APZ19_RS26875	COG1566	PFAM secretion protein HlyD family protein
APZ19_RS26905	COG0813	purine-nucleoside phosphorylase activity
APZ19_RS26915	COG3272	Protein of unknown function (DUF1722)
APZ19_RS26920	COG0789	Transcriptional regulator
APZ19_RS26925	COG0415	Belongs to the DNA photolyase family
APZ19_RS26930	COG1388	LysM domain
APZ19_RS26930	COG1376	ErfK ybiS ycfS ynhG family protein
APZ19_RS26940	COG0513	Belongs to the DEAD box helicase family
APZ19_RS26945	COG1770	oligopeptidase
APZ19_RS26950	COG4771	TonB-dependent receptor
APZ19_RS26970	COG0840	transmembrane signaling receptor activity
APZ19_RS26980	COG0573	inorganic phosphate transmembrane transporter activity
APZ19_RS26985	COG0581	inorganic phosphate transmembrane transporter activity
APZ19_RS26990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APZ19_RS27005	COG2304	oxidoreductase activity
APZ19_RS27025	COG0714	Associated with various cellular activities
APZ19_RS27045	COG0840	transmembrane signaling receptor activity
APZ19_RS27080	COG0110	maltose O-acetyltransferase activity
APZ19_RS27085	COG2204	response regulator
APZ19_RS27100	COG0573	inorganic phosphate transmembrane transporter activity
APZ19_RS27110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APZ19_RS27115	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS27165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APZ19_RS27170	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
APZ19_RS27380	COG3012	SEC-C Motif Domain Protein
APZ19_RS27405	COG3081	Nucleoid-associated protein
APZ19_RS27430	COG2842	Transposition protein
APZ19_RS27455	COG1301	dicarboxylic acid transport
APZ19_RS27465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APZ19_RS27500	COG1566	PFAM secretion protein HlyD family protein
APZ19_RS27505	COG0583	DNA-binding transcription factor activity
APZ19_RS27520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS27520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS27520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APZ19_RS27525	COG2207	Transcriptional regulator
APZ19_RS27535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS27540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APZ19_RS27545	COG0583	DNA-binding transcription factor activity
APZ19_RS27555	COG2084	Dehydrogenase
APZ19_RS27560	COG0753	catalase activity
APZ19_RS27570	COG2130	NADP-dependent
APZ19_RS27575	COG1309	transcriptional regulator
APZ19_RS27615	COG0438	transferase activity, transferring glycosyl groups
APZ19_RS27640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APZ19_RS27645	COG3842	ATPase activity
APZ19_RS27655	COG1175	transmembrane transport
APZ19_RS27660	COG3833	ABC-type maltose transport systems, permease component
APZ19_RS27690	COG2354	Protein conserved in bacteria
APZ19_RS27705	COG0401	homolog of Blt101
APZ19_RS27710	COG3217	Mosc domain protein beta barrel domain protein
APZ19_RS27710	COG0633	Ferredoxin
APZ19_RS27710	COG0633	Ferredoxin
APZ19_RS27710	COG3217	Mosc domain protein beta barrel domain protein
APZ19_RS27720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APZ19_RS27760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APZ19_RS27765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APZ19_RS27775	COG0848	biopolymer transport protein
APZ19_RS27780	COG0811	peptide transport
APZ19_RS27785	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APZ19_RS27795	COG3721	Heme iron utilization protein
APZ19_RS27800	COG0748	coenzyme F420 binding
APZ19_RS27815	COG0835	chemotaxis
APZ19_RS27815	COG0784	Response regulator, receiver
APZ19_RS27820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APZ19_RS27825	COG0366	Alpha amylase catalytic
APZ19_RS27830	COG0604	alcohol dehydrogenase
APZ19_RS27830	COG3321	synthase
APZ19_RS27830	COG1028	Short-chain dehydrogenase reductase Sdr
APZ19_RS27885	COG0583	DNA-binding transcription factor activity
APZ19_RS27900	COG2249	NAD(P)H dehydrogenase (quinone) activity
APZ19_RS27905	COG0583	DNA-binding transcription factor activity
APZ19_RS27925	COG2814	Major facilitator Superfamily
APZ19_RS27940	COG1335	isochorismatase
APZ19_RS27955	COG2194	sulfuric ester hydrolase activity
APZ19_RS27960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APZ19_RS27970	COG2205	protein histidine kinase activity
APZ19_RS27975	COG0745	RESPONSE REGULATOR receiver
APZ19_RS27980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APZ19_RS27985	COG4948	Mandelate Racemase Muconate Lactonizing
APZ19_RS27990	COG1053	succinate dehydrogenase
APZ19_RS27990	COG3976	FMN-binding domain protein
APZ19_RS28000	COG4221	oxidoreductase activity
APZ19_RS28015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APZ19_RS28035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APZ19_RS28045	COG2814	Major facilitator Superfamily
APZ19_RS28060	COG1418	mRNA catabolic process
APZ19_RS28075	COG0402	S-adenosylhomocysteine deaminase activity
APZ19_RS28080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APZ19_RS28085	COG2239	Acts as a magnesium transporter
APZ19_RS28090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APZ19_RS28095	COG1566	PFAM secretion protein HlyD family protein
APZ19_RS28120	COG0745	RESPONSE REGULATOR receiver
APZ19_RS28125	COG2205	protein histidine kinase activity
APZ19_RS28145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APZ19_RS28155	COG0531	amino acid
APZ19_RS28160	COG1522	sequence-specific DNA binding
APZ19_RS28195	COG0673	inositol 2-dehydrogenase activity
APZ19_RS28370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ19_RS28405	COG3504	Conjugal transfer protein
APZ19_RS28420	COG4962	Type ii secretion system protein e
APZ19_RS28430	COG3451	type IV secretory pathway VirB4
APZ19_RS28435	COG5268	conjugation
APZ19_RS28460	COG1192	Involved in chromosome partitioning
APZ19_RS28485	COG0419	ATPase involved in DNA repair
APZ19_RS28595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APZ19_RS28710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APZ19_RS28745	COG3504	Conjugal transfer protein
APZ19_RS28765	COG4962	Type ii secretion system protein e
APZ19_RS28775	COG3451	type IV secretory pathway VirB4
APZ19_RS28780	COG5268	conjugation
APZ19_RS28810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
APZ19_RS28855	COG1192	Involved in chromosome partitioning
APZ19_RS28915	COG2885	chlorophyll binding