locus-tag	class	description
GZK95_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GZK95_RS00015	COG0706	membrane insertase activity
GZK95_RS00035	COG1126	abc transporter atp-binding protein
GZK95_RS00055	COG0592	DNA-directed DNA polymerase activity
GZK95_RS00060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZK95_RS00065	COG0187	DNA topoisomerase II activity
GZK95_RS00070	COG0071	Belongs to the small heat shock protein (HSP20) family
GZK95_RS00075	COG3977	Valine--pyruvate aminotransferase
GZK95_RS00080	COG0751	glycine-tRNA ligase activity
GZK95_RS00085	COG0752	glycyl-tRNA synthetase alpha subunit
GZK95_RS00090	COG2119	membrane
GZK95_RS00115	COG0604	alcohol dehydrogenase
GZK95_RS00125	COG0129	dihydroxy-acid dehydratase activity
GZK95_RS00130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZK95_RS00135	COG3978	acetolactate synthase activity
GZK95_RS00145	COG0606	chelatase, subunit chli
GZK95_RS00155	COG0204	Acyl-transferase
GZK95_RS00160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GZK95_RS00165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GZK95_RS00175	COG3084	Protein conserved in bacteria
GZK95_RS00180	COG4326	sporulation control protein
GZK95_RS00185	COG1272	protein, Hemolysin III
GZK95_RS00190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZK95_RS00195	COG0569	domain protein
GZK95_RS00200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZK95_RS00200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GZK95_RS00205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZK95_RS00210	COG0242	peptide deformylase activity
GZK95_RS00220	COG0758	DNA mediated transformation
GZK95_RS00230	COG0551	DNA topoisomerase type I activity
GZK95_RS00235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GZK95_RS00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZK95_RS00245	COG0009	L-threonylcarbamoyladenylate synthase
GZK95_RS00250	COG0408	coproporphyrinogen oxidase activity
GZK95_RS00255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZK95_RS00265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GZK95_RS00310	COG1368	sulfuric ester hydrolase activity
GZK95_RS00315	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GZK95_RS00320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZK95_RS00330	COG2204	response regulator
GZK95_RS00335	COG3852	Histidine kinase
GZK95_RS00340	COG0174	glutamine synthetase
GZK95_RS00365	COG1490	D-aminoacyl-tRNA deacylase activity
GZK95_RS00370	COG0456	acetyltransferase
GZK95_RS00385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GZK95_RS00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GZK95_RS00395	COG3031	protein transport across the cell outer membrane
GZK95_RS00405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GZK95_RS00410	COG1459	type II secretion system
GZK95_RS00415	COG2165	general secretion pathway protein
GZK95_RS00420	COG2165	general secretion pathway protein
GZK95_RS00425	COG2165	general secretion pathway protein
GZK95_RS00430	COG4795	General secretion pathway protein
GZK95_RS00435	COG3156	type II secretion system protein K
GZK95_RS00440	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GZK95_RS00445	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GZK95_RS00455	COG3829	transcription factor binding
GZK95_RS00460	COG0833	amino acid
GZK95_RS00465	COG3457	Alanine racemase
GZK95_RS00470	COG0531	amino acid
GZK95_RS00480	COG2205	protein histidine kinase activity
GZK95_RS00485	COG0745	RESPONSE REGULATOR receiver
GZK95_RS00490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GZK95_RS00495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZK95_RS00500	COG2183	response to ionizing radiation
GZK95_RS00510	COG0596	Alpha beta hydrolase
GZK95_RS00525	COG0494	nUDIX hydrolase
GZK95_RS00530	COG1218	3'(2'),5'-bisphosphate nucleotidase
GZK95_RS00540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GZK95_RS00545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZK95_RS00550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZK95_RS00555	COG1758	RNA polymerase activity
GZK95_RS00560	COG0194	GDP metabolic process
GZK95_RS00565	COG2252	PERMEase
GZK95_RS00580	COG2186	Transcriptional regulator
GZK95_RS00585	COG3250	beta-galactosidase activity
GZK95_RS00595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GZK95_RS00610	COG0246	Mannitol dehydrogenase
GZK95_RS00615	COG1904	glucuronate isomerase
GZK95_RS00620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZK95_RS00625	COG0800	Aldolase
GZK95_RS00645	COG2731	YhcH YjgK YiaL family protein
GZK95_RS00655	COG1561	YicC-like family, N-terminal region
GZK95_RS00660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GZK95_RS00665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZK95_RS00670	COG1560	Kdo2-lipid A biosynthetic process
GZK95_RS00675	COG1560	Kdo2-lipid A biosynthetic process
GZK95_RS00680	COG1309	transcriptional regulator
GZK95_RS00685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZK95_RS00690	COG2003	Belongs to the UPF0758 family
GZK95_RS00700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZK95_RS00720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GZK95_RS00725	COG0859	PFAM glycosyl transferase family 9
GZK95_RS00730	COG0463	Glycosyl transferase, family 2
GZK95_RS00735	COG0859	PFAM glycosyl transferase family 9
GZK95_RS00740	COG3642	lipopolysaccharide core region biosynthetic process
GZK95_RS00745	COG1519	Transferase
GZK95_RS00755	COG0859	PFAM glycosyl transferase family 9
GZK95_RS00785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZK95_RS00795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GZK95_RS00810	COG1088	dTDP-glucose 4,6-dehydratase activity
GZK95_RS00840	COG1215	transferase activity, transferring glycosyl groups
GZK95_RS00850	COG0438	transferase activity, transferring glycosyl groups
GZK95_RS00890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZK95_RS00900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GZK95_RS00910	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GZK95_RS00910	COG0662	Cupin 2, conserved barrel domain protein
GZK95_RS00940	COG1494	fructose-1,6-bisphosphatase
GZK95_RS00950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GZK95_RS00955	COG0460	homoserine dehydrogenase
GZK95_RS00955	COG0527	aspartate kinase activity
GZK95_RS00960	COG0626	cystathionine gamma-synthase activity
GZK95_RS00970	COG0281	malic enzyme
GZK95_RS00975	COG0254	rRNA binding
GZK95_RS00980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GZK95_RS00985	COG1609	Transcriptional regulator
GZK95_RS00990	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GZK95_RS00995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GZK95_RS01000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GZK95_RS01010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZK95_RS01025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZK95_RS01030	COG1053	succinate dehydrogenase
GZK95_RS01040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZK95_RS01045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GZK95_RS01050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZK95_RS01055	COG1045	serine acetyltransferase
GZK95_RS01065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GZK95_RS01075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GZK95_RS01080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GZK95_RS01085	COG0137	argininosuccinate synthase activity
GZK95_RS01090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GZK95_RS01090	COG0165	Argininosuccinate lyase
GZK95_RS01100	COG3634	alkyl hydroperoxide reductase activity
GZK95_RS01110	COG0678	peroxiredoxin activity
GZK95_RS01110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GZK95_RS01120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GZK95_RS01165	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GZK95_RS01170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZK95_RS01175	COG0546	phosphoglycolate phosphatase activity
GZK95_RS01180	COG0180	Tryptophanyl-tRNA synthetase
GZK95_RS01190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZK95_RS01200	COG1012	belongs to the aldehyde dehydrogenase family
GZK95_RS01215	COG3954	Phosphoribulokinase
GZK95_RS01225	COG0429	hydrolase of the alpha beta-hydrolase fold
GZK95_RS01235	COG0488	(ABC) transporter
GZK95_RS01240	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZK95_RS01255	COG1047	Peptidyl-prolyl cis-trans
GZK95_RS01260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZK95_RS01265	COG0698	ribose 5-phosphate isomerase
GZK95_RS01280	COG1737	Transcriptional regulator
GZK95_RS01285	COG1446	asparaginase
GZK95_RS01290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZK95_RS01295	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GZK95_RS01300	COG0402	S-adenosylhomocysteine deaminase activity
GZK95_RS01305	COG0557	exoribonuclease II activity
GZK95_RS01310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZK95_RS01315	COG0051	transcription antitermination factor activity, RNA binding
GZK95_RS01320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZK95_RS01340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZK95_RS01345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZK95_RS01350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZK95_RS01375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZK95_RS01380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GZK95_RS01395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZK95_RS01410	COG1841	ribosomal large subunit assembly
GZK95_RS01415	COG0200	Binds to the 23S rRNA
GZK95_RS01420	COG0201	protein transport
GZK95_RS01425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GZK95_RS01430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZK95_RS01435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GZK95_RS01450	COG0203	ribosomal protein L17
GZK95_RS01460	COG0545	Peptidyl-prolyl cis-trans isomerase
GZK95_RS01475	COG2153	protein acetylation
GZK95_RS01490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZK95_RS01490	COG1648	precorrin-2 dehydrogenase activity
GZK95_RS01495	COG0175	sulfate reduction
GZK95_RS01505	COG3273	potassium ion transport
GZK95_RS01505	COG0471	metal ion transport
GZK95_RS01510	COG0529	Catalyzes the synthesis of activated sulfate
GZK95_RS01520	COG0735	belongs to the Fur family
GZK95_RS01525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZK95_RS01540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GZK95_RS01545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZK95_RS01630	COG1410	methionine synthase
GZK95_RS01630	COG0646	methionine synthase
GZK95_RS01635	COG2239	Acts as a magnesium transporter
GZK95_RS01640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS01645	COG1660	Displays ATPase and GTPase activities
GZK95_RS01650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS01655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZK95_RS01665	COG1137	ATPase activity
GZK95_RS01670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GZK95_RS01680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GZK95_RS01685	COG0517	IMP dehydrogenase activity
GZK95_RS01685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GZK95_RS01695	COG1127	ABC transporter
GZK95_RS01700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GZK95_RS01705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GZK95_RS01710	COG2854	intermembrane phospholipid transfer
GZK95_RS01720	COG5007	Belongs to the BolA IbaG family
GZK95_RS01730	COG0204	Acyl-transferase
GZK95_RS01765	COG0840	transmembrane signaling receptor activity
GZK95_RS01790	COG0741	lytic transglycosylase activity
GZK95_RS01795	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GZK95_RS01815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GZK95_RS01820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GZK95_RS01835	COG0762	integral membrane protein
GZK95_RS01840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZK95_RS01845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GZK95_RS01860	COG0527	aspartate kinase activity
GZK95_RS01865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GZK95_RS01875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZK95_RS01890	COG0629	single-stranded DNA binding
GZK95_RS01895	COG2200	EAL domain
GZK95_RS01895	COG2199	diguanylate cyclase activity
GZK95_RS01920	COG3409	Peptidoglycan-binding domain 1 protein
GZK95_RS01920	COG3267	Type II secretory pathway component ExeA
GZK95_RS01930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GZK95_RS01935	COG1459	type II secretion system
GZK95_RS01980	COG1077	Cell shape determining protein MreB Mrl
GZK95_RS01985	COG1792	Involved in formation and maintenance of cell shape
GZK95_RS01990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GZK95_RS01995	COG0424	maF-like protein
GZK95_RS02000	COG1530	ribonuclease E activity
GZK95_RS02005	COG3164	Protein of unknown function
GZK95_RS02010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZK95_RS02015	COG0312	modulator of DNA gyrase
GZK95_RS02050	COG2358	TRAP transporter, solute receptor (TAXI family
GZK95_RS02055	COG1438	arginine binding
GZK95_RS02070	COG0142	geranyltranstransferase activity
GZK95_RS02075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZK95_RS02080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZK95_RS02085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZK95_RS02090	COG3610	response to peptide
GZK95_RS02095	COG3610	response to peptide
GZK95_RS02105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZK95_RS02115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GZK95_RS02120	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GZK95_RS02125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZK95_RS02130	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GZK95_RS02135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GZK95_RS02140	COG0251	oxidation-reduction process
GZK95_RS02145	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GZK95_RS02155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GZK95_RS02160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GZK95_RS02165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZK95_RS02170	COG0564	pseudouridine synthase activity
GZK95_RS02175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZK95_RS02180	COG0525	valine-tRNA ligase activity
GZK95_RS02185	COG2927	DNA polymerase III (CHI subunit)
GZK95_RS02195	COG0795	lipopolysaccharide-transporting ATPase activity
GZK95_RS02200	COG0795	lipopolysaccharide-transporting ATPase activity
GZK95_RS02210	COG0157	Belongs to the NadC ModD family
GZK95_RS02225	COG4974	Belongs to the 'phage' integrase family
GZK95_RS02230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GZK95_RS02235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GZK95_RS02240	COG2186	Transcriptional regulator
GZK95_RS02245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GZK95_RS02250	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZK95_RS02255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZK95_RS02270	COG0288	reversible hydration of carbon dioxide
GZK95_RS02275	COG0659	secondary active sulfate transmembrane transporter activity
GZK95_RS02280	COG1131	(ABC) transporter
GZK95_RS02285	COG0842	Transport permease protein
GZK95_RS02295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GZK95_RS02300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZK95_RS02310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZK95_RS02315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GZK95_RS02325	COG1643	Atp-dependent helicase
GZK95_RS02330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZK95_RS02335	COG1752	Esterase of the alpha-beta hydrolase superfamily
GZK95_RS02340	COG1049	propionate catabolic process, 2-methylcitrate cycle
GZK95_RS02345	COG1929	Belongs to the glycerate kinase type-1 family
GZK95_RS02350	COG2610	gluconate transmembrane transporter activity
GZK95_RS02355	COG3835	regulator
GZK95_RS02370	COG0004	ammonium transporteR
GZK95_RS02375	COG1840	ABC-type Fe3 transport system, periplasmic component
GZK95_RS02380	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GZK95_RS02390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZK95_RS02405	COG2971	BadF BadG BcrA BcrD
GZK95_RS02415	COG4608	Belongs to the ABC transporter superfamily
GZK95_RS02420	COG0444	Belongs to the ABC transporter superfamily
GZK95_RS02425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZK95_RS02435	COG0747	negative chemotaxis
GZK95_RS02440	COG0784	Response regulator, receiver
GZK95_RS02440	COG2205	protein histidine kinase activity
GZK95_RS02450	COG0628	permease
GZK95_RS02455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GZK95_RS02465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS02475	COG0739	heme binding
GZK95_RS02480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZK95_RS02490	COG2027	D-alanyl-D-alanine carboxypeptidase
GZK95_RS02500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZK95_RS02505	COG1534	Rna-binding protein
GZK95_RS02515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZK95_RS02520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GZK95_RS02530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZK95_RS02550	COG0195	Participates in both transcription termination and antitermination
GZK95_RS02555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZK95_RS02560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZK95_RS02570	COG1538	Outer membrane efflux protein
GZK95_RS02575	COG0494	nUDIX hydrolase
GZK95_RS02580	COG3151	Protein conserved in bacteria
GZK95_RS02590	COG3150	esterase
GZK95_RS02595	COG0187	DNA topoisomerase II activity
GZK95_RS02600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZK95_RS02605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZK95_RS02610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZK95_RS02615	COG3105	Protein conserved in bacteria
GZK95_RS02620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GZK95_RS02625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZK95_RS02630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GZK95_RS02635	COG0723	plastoquinol--plastocyanin reductase activity
GZK95_RS02640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GZK95_RS02645	COG2857	Cytochrome c1
GZK95_RS02650	COG0625	glutathione transferase activity
GZK95_RS02655	COG2969	positive regulation of protein catabolic process
GZK95_RS02665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GZK95_RS02670	COG0792	nuclease activity
GZK95_RS02675	COG3107	peptidoglycan biosynthetic process
GZK95_RS02680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GZK95_RS02695	COG3116	cell division
GZK95_RS02700	COG0768	penicillin binding
GZK95_RS02710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZK95_RS02725	COG0772	Belongs to the SEDS family
GZK95_RS02730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZK95_RS02740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GZK95_RS02745	COG0849	cell division
GZK95_RS02750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GZK95_RS02755	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GZK95_RS02765	COG0653	protein targeting
GZK95_RS02770	COG0494	nUDIX hydrolase
GZK95_RS02780	COG0505	Belongs to the CarA family
GZK95_RS02785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZK95_RS02790	COG0730	response to heat
GZK95_RS02795	COG0583	DNA-binding transcription factor activity
GZK95_RS02800	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GZK95_RS02810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GZK95_RS02825	COG1115	amino acid carrier protein
GZK95_RS02830	COG3022	response to hydroperoxide
GZK95_RS02860	COG0084	hydrolase, TatD family'
GZK95_RS02865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZK95_RS02875	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GZK95_RS02880	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GZK95_RS02885	COG0813	purine-nucleoside phosphorylase activity
GZK95_RS02895	COG0560	Phosphoserine phosphatase
GZK95_RS02905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GZK95_RS02910	COG5001	Diguanylate cyclase
GZK95_RS02915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZK95_RS02920	COG0583	DNA-binding transcription factor activity
GZK95_RS02955	COG4964	Belongs to the GSP D family
GZK95_RS03010	COG0583	DNA-binding transcription factor activity
GZK95_RS03020	COG0534	Mate efflux family protein
GZK95_RS03040	COG2171	N-acyltransferase activity
GZK95_RS03055	COG0450	alkyl hydroperoxide reductase
GZK95_RS03060	COG0583	DNA-binding transcription factor activity
GZK95_RS03065	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GZK95_RS03075	COG0517	IMP dehydrogenase activity
GZK95_RS03080	COG0840	transmembrane signaling receptor activity
GZK95_RS03085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GZK95_RS03090	COG0343	queuine tRNA-ribosyltransferase activity
GZK95_RS03095	COG1862	Preprotein translocase
GZK95_RS03100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZK95_RS03105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZK95_RS03115	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GZK95_RS03125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GZK95_RS03135	COG2974	May be involved in recombination
GZK95_RS03140	COG0745	RESPONSE REGULATOR receiver
GZK95_RS03145	COG5002	protein histidine kinase activity
GZK95_RS03155	COG0248	Ppx GppA phosphatase
GZK95_RS03160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GZK95_RS03170	COG0581	inorganic phosphate transmembrane transporter activity
GZK95_RS03175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZK95_RS03180	COG0704	Plays a role in the regulation of phosphate uptake
GZK95_RS03185	COG3142	Participates in the control of copper homeostasis
GZK95_RS03200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS03200	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS03210	COG3715	PTS system
GZK95_RS03215	COG3716	PTS system mannose fructose sorbose family IID component
GZK95_RS03225	COG2188	Transcriptional regulator
GZK95_RS03230	COG1566	PFAM secretion protein HlyD family protein
GZK95_RS03235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZK95_RS03240	COG3141	response to X-ray
GZK95_RS03245	COG0583	DNA-binding transcription factor activity
GZK95_RS03265	COG1132	(ABC) transporter
GZK95_RS03275	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GZK95_RS03280	COG1074	ATP-dependent DNA helicase activity
GZK95_RS03285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GZK95_RS03305	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GZK95_RS03310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GZK95_RS03315	COG2166	iron-sulfur cluster assembly
GZK95_RS03325	COG1426	Protein conserved in bacteria
GZK95_RS03330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZK95_RS03335	COG0124	histidyl-tRNA synthetase
GZK95_RS03340	COG2976	Protein conserved in bacteria
GZK95_RS03345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZK95_RS03350	COG1160	GTP binding
GZK95_RS03370	COG0516	GMP reductase activity
GZK95_RS03370	COG0517	IMP dehydrogenase activity
GZK95_RS03375	COG0519	Catalyzes the synthesis of GMP from XMP
GZK95_RS03375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GZK95_RS03380	COG1584	GPR1 FUN34 yaaH family protein
GZK95_RS03385	COG1115	amino acid carrier protein
GZK95_RS03390	COG2873	o-acetylhomoserine
GZK95_RS03395	COG2354	Protein conserved in bacteria
GZK95_RS03400	COG1263	PTS System
GZK95_RS03400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS03400	COG2190	(PTS) system
GZK95_RS03405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GZK95_RS03410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZK95_RS03410	COG3153	acetyltransferase
GZK95_RS03425	COG4676	Protein conserved in bacteria
GZK95_RS03435	COG1121	(ABC) transporter
GZK95_RS03440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZK95_RS03445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZK95_RS03495	COG0582	viral genome integration into host DNA
GZK95_RS03510	COG2867	negative regulation of translational initiation
GZK95_RS03515	COG2914	Belongs to the UPF0125 (RnfH) family
GZK95_RS03520	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZK95_RS03525	COG0497	DNA recombination
GZK95_RS03530	COG0583	DNA-binding transcription factor activity
GZK95_RS03550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GZK95_RS03590	COG0484	heat shock protein binding
GZK95_RS03620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GZK95_RS03625	COG1253	flavin adenine dinucleotide binding
GZK95_RS03635	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GZK95_RS03665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GZK95_RS03670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZK95_RS03675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GZK95_RS03680	COG1187	pseudouridine synthase activity
GZK95_RS03685	COG2840	Smr protein MutS2
GZK95_RS03705	COG3104	oligopeptide transport
GZK95_RS03710	COG0367	asparagine synthase
GZK95_RS03715	COG4651	solute:proton antiporter activity
GZK95_RS03715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GZK95_RS03720	COG1940	carbohydrate kinase activity
GZK95_RS03720	COG1846	Transcriptional regulator
GZK95_RS03725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZK95_RS03730	COG2190	(PTS) system
GZK95_RS03730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS03730	COG1263	PTS System
GZK95_RS03735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZK95_RS03740	COG0735	belongs to the Fur family
GZK95_RS03750	COG0716	FMN binding
GZK95_RS03760	COG0596	Alpha beta hydrolase
GZK95_RS03765	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GZK95_RS03770	COG0033	Phosphoglucomutase
GZK95_RS03780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZK95_RS03795	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GZK95_RS03800	COG1053	succinate dehydrogenase
GZK95_RS03810	COG0567	Dehydrogenase, E1 component
GZK95_RS03815	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZK95_RS03850	COG3098	single-species biofilm formation
GZK95_RS03855	COG0564	pseudouridine synthase activity
GZK95_RS03860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GZK95_RS03865	COG0142	geranyltranstransferase activity
GZK95_RS03875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GZK95_RS03880	COG2885	chlorophyll binding
GZK95_RS03885	COG0301	tRNA thio-modification
GZK95_RS03885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZK95_RS03890	COG0583	DNA-binding transcription factor activity
GZK95_RS03900	COG2363	Small membrane protein
GZK95_RS03905	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GZK95_RS03915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZK95_RS03920	COG1611	Belongs to the LOG family
GZK95_RS03925	COG3706	GGDEF domain
GZK95_RS03935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GZK95_RS03935	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GZK95_RS03945	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GZK95_RS03955	COG1876	peptidase activity
GZK95_RS03965	COG1393	Belongs to the ArsC family
GZK95_RS03985	COG4235	cytochrome complex assembly
GZK95_RS03995	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GZK95_RS04000	COG0437	4 iron, 4 sulfur cluster binding
GZK95_RS04005	COG3301	Polysulphide reductase, NrfD
GZK95_RS04010	COG1138	Cytochrome C-type biogenesis protein
GZK95_RS04020	COG4235	cytochrome complex assembly
GZK95_RS04020	COG3088	subunit of a heme lyase
GZK95_RS04030	COG2837	iron assimilation
GZK95_RS04045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZK95_RS04050	COG1334	flagellar protein FlaG
GZK95_RS04055	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GZK95_RS04065	COG1516	flagellar protein fliS
GZK95_RS04075	COG4191	Histidine kinase
GZK95_RS04085	COG1677	Flagellar hook-basal body complex protein FliE
GZK95_RS04095	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZK95_RS04145	COG1987	bacterial-type flagellum assembly
GZK95_RS04150	COG1684	flagellar biosynthetic protein fliR
GZK95_RS04160	COG2840	Smr protein MutS2
GZK95_RS04165	COG2890	protein-(glutamine-N5) methyltransferase activity
GZK95_RS04170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZK95_RS04175	COG2860	membrane
GZK95_RS04180	COG3101	peptidyl-lysine hydroxylation
GZK95_RS04210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZK95_RS04215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZK95_RS04220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZK95_RS04235	COG0101	tRNA pseudouridine synthase activity
GZK95_RS04240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GZK95_RS04245	COG0285	dihydrofolate synthase activity
GZK95_RS04250	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GZK95_RS04255	COG1286	toxin biosynthetic process
GZK95_RS04260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GZK95_RS04265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZK95_RS04270	COG1121	(ABC) transporter
GZK95_RS04275	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GZK95_RS04280	COG4977	sequence-specific DNA binding
GZK95_RS04285	COG1918	ferrous iron import across plasma membrane
GZK95_RS04315	COG0018	arginyl-trna synthetase
GZK95_RS04320	COG3102	Protein conserved in bacteria
GZK95_RS04325	COG1025	Belongs to the peptidase M16 family
GZK95_RS04330	COG2062	phosphohistidine phosphatase, SixA
GZK95_RS04360	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GZK95_RS04365	COG2198	Histidine kinase
GZK95_RS04365	COG0784	Response regulator, receiver
GZK95_RS04365	COG0643	Histidine kinase
GZK95_RS04375	COG1192	Involved in chromosome partitioning
GZK95_RS04385	COG0835	chemotaxis
GZK95_RS04395	COG4133	protoheme IX ABC transporter activity
GZK95_RS04400	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZK95_RS04405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZK95_RS04410	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZK95_RS04415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GZK95_RS04420	COG1138	Cytochrome C-type biogenesis protein
GZK95_RS04425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZK95_RS04440	COG2853	Lipoprotein
GZK95_RS04445	COG2067	long-chain fatty acid transport protein
GZK95_RS04460	COG1595	DNA-templated transcription, initiation
GZK95_RS04465	COG0183	Belongs to the thiolase family
GZK95_RS04470	COG1024	Enoyl-CoA hydratase
GZK95_RS04470	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZK95_RS04475	COG0133	tryptophan synthase activity
GZK95_RS04480	COG0778	Nitroreductase
GZK95_RS04485	COG0583	DNA-binding transcription factor activity
GZK95_RS04490	COG0745	RESPONSE REGULATOR receiver
GZK95_RS04495	COG2832	Protein of unknown function (DUF454)
GZK95_RS04500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZK95_RS04505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GZK95_RS04515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZK95_RS04525	COG0251	oxidation-reduction process
GZK95_RS04535	COG2188	Transcriptional regulator
GZK95_RS04560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS04560	COG1263	PTS System
GZK95_RS04565	COG2188	Transcriptional regulator
GZK95_RS04575	COG0667	Aldo Keto reductase
GZK95_RS04580	COG0800	Aldolase
GZK95_RS04585	COG3734	2-keto-3-deoxy-galactonokinase
GZK95_RS04590	COG4948	Mandelate Racemase Muconate Lactonizing
GZK95_RS04605	COG2271	Major facilitator Superfamily
GZK95_RS04620	COG2261	transglycosylase associated protein
GZK95_RS04625	COG2983	Belongs to the UPF0260 family
GZK95_RS04635	COG3501	Rhs element vgr protein
GZK95_RS04655	COG0668	transmembrane transport
GZK95_RS04675	COG2226	methyltransferase
GZK95_RS04690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZK95_RS04700	COG3139	Protein of unknown function (DUF1315)
GZK95_RS04705	COG3012	SEC-C Motif Domain Protein
GZK95_RS04710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GZK95_RS04720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZK95_RS04725	COG0215	cysteine-tRNA ligase activity
GZK95_RS04730	COG1435	thymidine kinase activity
GZK95_RS04735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GZK95_RS04740	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GZK95_RS04765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZK95_RS04770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZK95_RS04780	COG0596	Alpha beta hydrolase
GZK95_RS04795	COG3070	regulator of competence-specific genes
GZK95_RS04810	COG0745	RESPONSE REGULATOR receiver
GZK95_RS04815	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GZK95_RS04820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZK95_RS04825	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GZK95_RS04830	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GZK95_RS04835	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GZK95_RS04840	COG0745	RESPONSE REGULATOR receiver
GZK95_RS04875	COG3655	Transcriptional regulator
GZK95_RS04900	COG0189	ligase activity
GZK95_RS04900	COG4067	protein conserved in archaea
GZK95_RS04910	COG4106	trans-aconitate 2-methyltransferase activity
GZK95_RS04915	COG1801	Protein of unknown function DUF72
GZK95_RS04920	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZK95_RS04930	COG3706	GGDEF domain
GZK95_RS04935	COG1187	pseudouridine synthase activity
GZK95_RS04945	COG1278	Cold shock
GZK95_RS04950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GZK95_RS04955	COG0542	response to heat
GZK95_RS04965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZK95_RS04985	COG2116	formate transmembrane transporter activity
GZK95_RS04990	COG0390	transport system, permease component
GZK95_RS04995	COG4459	periplasmic nitrate reductase
GZK95_RS05000	COG3005	denitrification pathway
GZK95_RS05005	COG0243	molybdopterin cofactor binding
GZK95_RS05020	COG0632	four-way junction helicase activity
GZK95_RS05025	COG2255	four-way junction helicase activity
GZK95_RS05030	COG1271	oxidase subunit
GZK95_RS05035	COG1294	oxidase, subunit
GZK95_RS05040	COG4890	Cyd operon protein YbgT
GZK95_RS05050	COG0824	Thioesterase
GZK95_RS05055	COG0811	peptide transport
GZK95_RS05075	COG2885	chlorophyll binding
GZK95_RS05080	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GZK95_RS05085	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GZK95_RS05110	COG2205	protein histidine kinase activity
GZK95_RS05110	COG0784	Response regulator, receiver
GZK95_RS05195	COG0840	transmembrane signaling receptor activity
GZK95_RS05200	COG0589	response to stress
GZK95_RS05220	COG0583	DNA-binding transcription factor activity
GZK95_RS05225	COG2610	gluconate transmembrane transporter activity
GZK95_RS05235	COG1620	l-lactate permease
GZK95_RS05240	COG0247	lactate metabolic process
GZK95_RS05245	COG1139	Iron-sulfur cluster binding protein
GZK95_RS05250	COG1556	Lactate utilization protein
GZK95_RS05255	COG0583	DNA-binding transcription factor activity
GZK95_RS05280	COG3302	dmso reductase anchor subunit
GZK95_RS05285	COG0437	4 iron, 4 sulfur cluster binding
GZK95_RS05290	COG0243	molybdopterin cofactor binding
GZK95_RS05295	COG0784	Response regulator, receiver
GZK95_RS05295	COG2205	protein histidine kinase activity
GZK95_RS05320	COG5002	protein histidine kinase activity
GZK95_RS05325	COG0745	RESPONSE REGULATOR receiver
GZK95_RS05330	COG0463	Glycosyl transferase, family 2
GZK95_RS05335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GZK95_RS05350	COG1960	acyl-CoA dehydrogenase activity
GZK95_RS05355	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZK95_RS05365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS05375	COG0708	Exodeoxyribonuclease III
GZK95_RS05385	COG3923	Primosomal replication protein n
GZK95_RS05390	COG0730	response to heat
GZK95_RS05395	COG1199	ATP-dependent helicase activity
GZK95_RS05400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GZK95_RS05415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GZK95_RS05425	COG2226	methyltransferase
GZK95_RS05430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GZK95_RS05445	COG0300	oxidoreductase activity
GZK95_RS05460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GZK95_RS05480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZK95_RS05490	COG0482	sulfurtransferase activity
GZK95_RS05500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZK95_RS05505	COG2916	Histone family protein nucleoid-structuring protein H-NS
GZK95_RS05510	COG1757	Na H antiporter
GZK95_RS05515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GZK95_RS05520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GZK95_RS05525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZK95_RS05530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GZK95_RS05530	COG0131	Imidazoleglycerol-phosphate dehydratase
GZK95_RS05535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GZK95_RS05540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GZK95_RS05550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GZK95_RS05550	COG0140	phosphoribosyl-ATP diphosphatase activity
GZK95_RS05560	COG1227	inorganic diphosphatase activity
GZK95_RS05570	COG4172	Belongs to the ABC transporter superfamily
GZK95_RS05580	COG4171	peptide transport system, permease
GZK95_RS05585	COG4168	peptide transport system, permease
GZK95_RS05595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GZK95_RS05600	COG1842	Phage shock protein A
GZK95_RS05610	COG1983	PspC domain protein
GZK95_RS05630	COG2818	Glycosylase
GZK95_RS05635	COG0626	cystathionine gamma-synthase activity
GZK95_RS05645	COG0733	neurotransmitter:sodium symporter activity
GZK95_RS05655	COG0564	pseudouridine synthase activity
GZK95_RS05665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZK95_RS05670	COG4136	ATPase activity
GZK95_RS05675	COG4135	transport system, permease component
GZK95_RS05680	COG4134	Bacterial extracellular solute-binding protein
GZK95_RS05690	COG3313	Fe-S protein
GZK95_RS05705	COG2350	Protein conserved in bacteria
GZK95_RS05710	COG1607	acyl-coa hydrolase
GZK95_RS05740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZK95_RS05750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZK95_RS05755	COG0417	DNA replication proofreading
GZK95_RS05770	COG2197	response regulator
GZK95_RS05775	COG0322	excinuclease ABC activity
GZK95_RS05805	COG2133	pyrroloquinoline quinone binding
GZK95_RS05820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GZK95_RS05835	COG0456	acetyltransferase
GZK95_RS05840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZK95_RS05845	COG0072	phenylalanine-tRNA ligase activity
GZK95_RS05845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZK95_RS05850	COG0840	transmembrane signaling receptor activity
GZK95_RS05855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS05855	COG1263	PTS System
GZK95_RS05865	COG1621	beta-fructofuranosidase activity
GZK95_RS05870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZK95_RS05895	COG0583	DNA-binding transcription factor activity
GZK95_RS05910	COG0110	maltose O-acetyltransferase activity
GZK95_RS05915	COG0583	DNA-binding transcription factor activity
GZK95_RS05920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS05935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZK95_RS05940	COG1940	carbohydrate kinase activity
GZK95_RS05950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZK95_RS05955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GZK95_RS05960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GZK95_RS05965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZK95_RS05970	COG1737	Transcriptional regulator
GZK95_RS05975	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GZK95_RS05980	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GZK95_RS06005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZK95_RS06010	COG0583	DNA-binding transcription factor activity
GZK95_RS06015	COG1840	ABC-type Fe3 transport system, periplasmic component
GZK95_RS06020	COG3842	ATPase activity
GZK95_RS06060	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GZK95_RS06060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GZK95_RS06065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZK95_RS06065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS06070	COG3775	system Galactitol-specific IIC component
GZK95_RS06075	COG3414	Phosphotransferase system galactitol-specific IIB component
GZK95_RS06115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GZK95_RS06120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GZK95_RS06130	COG1902	pentaerythritol trinitrate reductase activity
GZK95_RS06130	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZK95_RS06135	COG0596	Alpha beta hydrolase
GZK95_RS06145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZK95_RS06160	COG3383	formate dehydrogenase (NAD+) activity
GZK95_RS06170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZK95_RS06180	COG3852	Histidine kinase
GZK95_RS06195	COG0659	secondary active sulfate transmembrane transporter activity
GZK95_RS06200	COG0318	PFAM AMP-dependent synthetase and ligase
GZK95_RS06235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GZK95_RS06240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GZK95_RS06245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZK95_RS06250	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GZK95_RS06265	COG1136	(ABC) transporter
GZK95_RS06275	COG1136	(ABC) transporter
GZK95_RS06275	COG0577	efflux transmembrane transporter activity
GZK95_RS06290	COG0672	)-iron permease
GZK95_RS06310	COG0583	DNA-binding transcription factor activity
GZK95_RS06335	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GZK95_RS06350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GZK95_RS06360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GZK95_RS06365	COG1280	lysine exporter protein (LysE YggA)
GZK95_RS06370	COG1115	amino acid carrier protein
GZK95_RS06390	COG2204	response regulator
GZK95_RS06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZK95_RS06395	COG4191	Histidine kinase
GZK95_RS06395	COG4191	Histidine kinase
GZK95_RS06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZK95_RS06405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GZK95_RS06415	COG1032	radical SAM domain protein
GZK95_RS06430	COG0583	DNA-binding transcription factor activity
GZK95_RS06435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GZK95_RS06445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GZK95_RS06450	COG1012	belongs to the aldehyde dehydrogenase family
GZK95_RS06450	COG1454	alcohol dehydrogenase
GZK95_RS06455	COG1737	Transcriptional regulator
GZK95_RS06460	COG0076	glutamate decarboxylase activity
GZK95_RS06470	COG2431	L-lysine efflux transmembrane transporter activity
GZK95_RS06480	COG3070	regulator of competence-specific genes
GZK95_RS06485	COG1280	lysine exporter protein (LysE YggA)
GZK95_RS06495	COG0840	transmembrane signaling receptor activity
GZK95_RS06500	COG1328	CTP reductase activity
GZK95_RS06505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GZK95_RS06640	COG0406	alpha-ribazole phosphatase activity
GZK95_RS06645	COG1280	lysine exporter protein (LysE YggA)
GZK95_RS06660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZK95_RS06670	COG0584	glycerophosphoryl diester phosphodiesterase
GZK95_RS06685	COG0745	RESPONSE REGULATOR receiver
GZK95_RS06690	COG2205	protein histidine kinase activity
GZK95_RS06695	COG4774	siderophore transport
GZK95_RS06705	COG0811	peptide transport
GZK95_RS06710	COG0811	peptide transport
GZK95_RS06715	COG0848	biopolymer transport protein
GZK95_RS06730	COG0765	amino acid transport
GZK95_RS06735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZK95_RS06745	COG1126	abc transporter atp-binding protein
GZK95_RS06750	COG3290	protein histidine kinase activity
GZK95_RS06755	COG4565	transcriptional regulatory protein
GZK95_RS06770	COG1741	Belongs to the pirin family
GZK95_RS06780	COG2390	Transcriptional regulator
GZK95_RS06790	COG1129	ABC transporter
GZK95_RS06795	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZK95_RS06805	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GZK95_RS06815	COG0235	Class ii aldolase
GZK95_RS06820	COG4160	amino acid transport
GZK95_RS06825	COG4215	(ABC) transporter
GZK95_RS06830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZK95_RS06835	COG1126	abc transporter atp-binding protein
GZK95_RS06850	COG2986	histidine ammonia-lyase
GZK95_RS06855	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GZK95_RS06860	COG0010	Belongs to the arginase family
GZK95_RS06875	COG4326	sporulation control protein
GZK95_RS06885	COG0500	methyltransferase
GZK95_RS06890	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GZK95_RS06895	COG0471	metal ion transport
GZK95_RS06915	COG0295	cytidine deaminase activity
GZK95_RS06920	COG1346	cytolysis
GZK95_RS06925	COG1380	Effector of murein hydrolase LrgA
GZK95_RS06930	COG2925	Exonuclease
GZK95_RS06935	COG2723	6-phospho-beta-galactosidase activity
GZK95_RS06940	COG2188	Transcriptional regulator
GZK95_RS06945	COG1278	Cold shock
GZK95_RS06965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GZK95_RS06985	COG2988	succinylglutamate desuccinylase activity
GZK95_RS06990	COG4139	cobalamin transport
GZK95_RS07020	COG0583	DNA-binding transcription factor activity
GZK95_RS07025	COG1914	H( )-stimulated, divalent metal cation uptake system
GZK95_RS07040	COG1451	nucleotide metabolic process
GZK95_RS07075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS07085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GZK95_RS07120	COG0602	queuosine metabolic process
GZK95_RS07125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GZK95_RS07130	COG3706	GGDEF domain
GZK95_RS07155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GZK95_RS07160	COG1254	Belongs to the acylphosphatase family
GZK95_RS07165	COG2920	part of a sulfur-relay system
GZK95_RS07170	COG0670	Belongs to the BI1 family
GZK95_RS07175	COG1126	abc transporter atp-binding protein
GZK95_RS07180	COG0765	amino acid transport
GZK95_RS07185	COG4597	amino acid ABC transporter
GZK95_RS07190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZK95_RS07200	COG1666	GTP binding
GZK95_RS07205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GZK95_RS07230	COG3008	intermembrane lipid transfer
GZK95_RS07235	COG2995	paraquat-inducible protein a
GZK95_RS07240	COG1132	(ABC) transporter
GZK95_RS07245	COG1956	GAF domain-containing protein
GZK95_RS07250	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GZK95_RS07255	COG0793	Belongs to the peptidase S41A family
GZK95_RS07265	COG0308	aminopeptidase N
GZK95_RS07275	COG2902	Dehydrogenase
GZK95_RS07300	COG0488	(ABC) transporter
GZK95_RS07315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZK95_RS07320	COG1067	ATP-dependent peptidase activity
GZK95_RS07345	COG3278	Belongs to the heme-copper respiratory oxidase family
GZK95_RS07360	COG2010	Cytochrome c
GZK95_RS07370	COG2217	Heavy metal translocating P-type atpase
GZK95_RS07385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZK95_RS07390	COG0589	response to stress
GZK95_RS07415	COG3842	ATPase activity
GZK95_RS07425	COG1177	transmembrane transport
GZK95_RS07430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZK95_RS07440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GZK95_RS07460	COG0437	4 iron, 4 sulfur cluster binding
GZK95_RS07465	COG3383	formate dehydrogenase (NAD+) activity
GZK95_RS07465	COG0243	molybdopterin cofactor binding
GZK95_RS07475	COG3381	protein complex oligomerization
GZK95_RS07495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GZK95_RS07505	COG0488	(ABC) transporter
GZK95_RS07520	COG4191	Histidine kinase
GZK95_RS07525	COG2204	response regulator
GZK95_RS07535	COG4662	Binding-protein-dependent transport system inner membrane component
GZK95_RS07540	COG3842	ATPase activity
GZK95_RS07545	COG0746	molybdenum cofactor guanylyltransferase activity
GZK95_RS07550	COG0303	'Molybdopterin
GZK95_RS07560	COG1940	carbohydrate kinase activity
GZK95_RS07575	COG1028	Short-chain dehydrogenase reductase Sdr
GZK95_RS07595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GZK95_RS07610	COG0840	transmembrane signaling receptor activity
GZK95_RS07610	COG3290	protein histidine kinase activity
GZK95_RS07615	COG0791	NLP P60 protein
GZK95_RS07625	COG3001	Fructosamine kinase
GZK95_RS07635	COG0307	riboflavin synthase, alpha
GZK95_RS07640	COG0534	Mate efflux family protein
GZK95_RS07650	COG1793	dna ligase
GZK95_RS07725	COG3501	Rhs element vgr protein
GZK95_RS07755	COG2204	response regulator
GZK95_RS07765	COG0438	transferase activity, transferring glycosyl groups
GZK95_RS07800	COG0297	glycogen (starch) synthase activity
GZK95_RS07810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZK95_RS07820	COG0247	lactate metabolic process
GZK95_RS07820	COG0277	FAD linked oxidase domain protein
GZK95_RS07850	COG0625	glutathione transferase activity
GZK95_RS07860	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GZK95_RS07870	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZK95_RS07890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS07895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZK95_RS07915	COG0840	transmembrane signaling receptor activity
GZK95_RS07930	COG2376	Dihydroxyacetone kinase
GZK95_RS07935	COG2376	Dihydroxyacetone kinase
GZK95_RS07960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZK95_RS07965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZK95_RS07970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZK95_RS07995	COG0019	diaminopimelate decarboxylase activity
GZK95_RS08020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GZK95_RS08040	COG0534	Mate efflux family protein
GZK95_RS08045	COG0702	epimerase
GZK95_RS08050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZK95_RS08060	COG1742	UPF0060 membrane protein
GZK95_RS08070	COG2207	Transcriptional regulator
GZK95_RS08085	COG2814	Major facilitator Superfamily
GZK95_RS08095	COG1061	Type III restriction enzyme res subunit
GZK95_RS08110	COG2205	protein histidine kinase activity
GZK95_RS08125	COG0586	Pfam SNARE associated Golgi protein
GZK95_RS08150	COG5001	Diguanylate cyclase
GZK95_RS08150	COG3300	MHYT domain
GZK95_RS08155	COG3046	protein related to deoxyribodipyrimidine photolyase
GZK95_RS08160	COG0415	Belongs to the DNA photolyase family
GZK95_RS08165	COG0783	Belongs to the Dps family
GZK95_RS08180	COG1609	Transcriptional regulator
GZK95_RS08190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZK95_RS08195	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZK95_RS08225	COG2390	Transcriptional regulator
GZK95_RS08240	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZK95_RS08250	COG1830	Aldolase
GZK95_RS08255	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GZK95_RS08275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GZK95_RS08290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZK95_RS08295	COG3108	Peptidase M15
GZK95_RS08300	COG2989	Protein conserved in bacteria
GZK95_RS08325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZK95_RS08340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZK95_RS08355	COG3106	COG3106 Predicted ATPase
GZK95_RS08375	COG0384	phenazine biosynthesis protein PhzF
GZK95_RS08390	COG5507	3-demethylubiquinone-9 3-methyltransferase
GZK95_RS08400	COG4115	mRNA cleavage
GZK95_RS08405	COG2161	toxin-antitoxin pair type II binding
GZK95_RS08475	COG0494	nUDIX hydrolase
GZK95_RS08480	COG0814	amino acid
GZK95_RS08485	COG1760	l-serine dehydratase
GZK95_RS08495	COG0720	synthase
GZK95_RS08505	COG0017	Asparaginyl-tRNA synthetase
GZK95_RS08520	COG1448	Aminotransferase
GZK95_RS08530	COG1643	Atp-dependent helicase
GZK95_RS08535	COG0281	malic enzyme
GZK95_RS08545	COG2949	membrane
GZK95_RS08570	COG0492	ferredoxin-NADP+ reductase activity
GZK95_RS08575	COG4988	ABC transporter
GZK95_RS08580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GZK95_RS08585	COG0006	proline dipeptidase activity
GZK95_RS08590	COG1522	sequence-specific DNA binding
GZK95_RS08595	COG1012	belongs to the aldehyde dehydrogenase family
GZK95_RS08600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZK95_RS08625	COG0583	DNA-binding transcription factor activity
GZK95_RS08635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZK95_RS08640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GZK95_RS08645	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GZK95_RS08660	COG3706	GGDEF domain
GZK95_RS08665	COG0733	neurotransmitter:sodium symporter activity
GZK95_RS08670	COG3033	Beta-eliminating lyase
GZK95_RS08675	COG3437	response regulator, receiver
GZK95_RS08680	COG3437	response regulator, receiver
GZK95_RS08680	COG3850	Histidine kinase
GZK95_RS08680	COG4999	Histidine kinase
GZK95_RS08680	COG2205	protein histidine kinase activity
GZK95_RS08685	COG1187	pseudouridine synthase activity
GZK95_RS08690	COG0009	L-threonylcarbamoyladenylate synthase
GZK95_RS08695	COG0613	PHP domain protein
GZK95_RS08705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZK95_RS08710	COG0512	Glutamine amidotransferase of anthranilate synthase
GZK95_RS08715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZK95_RS08720	COG0135	phosphoribosylanthranilate isomerase activity
GZK95_RS08720	COG0134	indole-3-glycerol-phosphate synthase activity
GZK95_RS08725	COG0133	tryptophan synthase activity
GZK95_RS08740	COG1643	Atp-dependent helicase
GZK95_RS08780	COG0443	Heat shock 70 kDa protein
GZK95_RS08785	COG0443	Heat shock 70 kDa protein
GZK95_RS08795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GZK95_RS08820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GZK95_RS08835	COG2313	pseudouridylate synthase activity
GZK95_RS08840	COG1522	sequence-specific DNA binding
GZK95_RS08840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZK95_RS08850	COG1136	(ABC) transporter
GZK95_RS08870	COG3275	phosphorelay sensor kinase activity
GZK95_RS08895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZK95_RS08910	COG1882	Formate acetyltransferase
GZK95_RS08920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GZK95_RS08925	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GZK95_RS08945	COG2766	serine protein kinase
GZK95_RS08950	COG2718	Belongs to the UPF0229 family
GZK95_RS08955	COG2719	SpoVR family
GZK95_RS08960	COG2197	response regulator
GZK95_RS08965	COG3850	Histidine kinase
GZK95_RS08970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GZK95_RS08970	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GZK95_RS08980	COG0243	molybdopterin cofactor binding
GZK95_RS08990	COG3005	denitrification pathway
GZK95_RS09000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GZK95_RS09010	COG1663	tetraacyldisaccharide 4'-kinase activity
GZK95_RS09015	COG1132	(ABC) transporter
GZK95_RS09020	COG2333	competence protein COMEC
GZK95_RS09020	COG0658	competence protein
GZK95_RS09030	COG4591	ABC-type transport system involved in lipoprotein release permease component
GZK95_RS09035	COG1136	(ABC) transporter
GZK95_RS09040	COG4591	ABC-type transport system involved in lipoprotein release permease component
GZK95_RS09050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GZK95_RS09065	COG1252	NADH dehydrogenase
GZK95_RS09095	COG0537	adenosine 5'-monophosphoramidase activity
GZK95_RS09110	COG3604	Transcriptional regulator
GZK95_RS09115	COG1151	hydroxylamine reductase activity
GZK95_RS09120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZK95_RS09125	COG2186	Transcriptional regulator
GZK95_RS09130	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GZK95_RS09155	COG0814	amino acid
GZK95_RS09170	COG1882	Formate acetyltransferase
GZK95_RS09175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZK95_RS09185	COG1522	sequence-specific DNA binding
GZK95_RS09190	COG0686	Belongs to the AlaDH PNT family
GZK95_RS09195	COG3092	negative regulation of chromosome organization
GZK95_RS09200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZK95_RS09205	COG0280	phosphate acetyltransferase
GZK95_RS09205	COG0857	belongs to the CobB CobQ family
GZK95_RS09210	COG3174	membrane
GZK95_RS09220	COG3302	dmso reductase anchor subunit
GZK95_RS09225	COG0437	4 iron, 4 sulfur cluster binding
GZK95_RS09230	COG0243	molybdopterin cofactor binding
GZK95_RS09235	COG3381	protein complex oligomerization
GZK95_RS09240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GZK95_RS09240	COG2221	Nitrite and sulphite reductase 4Fe-4S
GZK95_RS09250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS09255	COG1309	transcriptional regulator
GZK95_RS09260	COG0435	Glutathione S-transferase
GZK95_RS09270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZK95_RS09280	COG0444	Belongs to the ABC transporter superfamily
GZK95_RS09285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZK95_RS09290	COG0601	transmembrane transport
GZK95_RS09300	COG4221	oxidoreductase activity
GZK95_RS09310	COG3300	MHYT domain
GZK95_RS09310	COG5001	Diguanylate cyclase
GZK95_RS09320	COG3064	Membrane
GZK95_RS09325	COG1418	mRNA catabolic process
GZK95_RS09330	COG0456	acetyltransferase
GZK95_RS09335	COG0814	amino acid
GZK95_RS09340	COG3681	Belongs to the UPF0597 family
GZK95_RS09345	COG1522	sequence-specific DNA binding
GZK95_RS09360	COG5001	Diguanylate cyclase
GZK95_RS09360	COG3300	MHYT domain
GZK95_RS09380	COG1946	Acyl-CoA thioesterase
GZK95_RS09385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZK95_RS09390	COG0406	alpha-ribazole phosphatase activity
GZK95_RS09405	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GZK95_RS09460	COG0310	cobalt ion transport
GZK95_RS09465	COG0310	cobalt ion transport
GZK95_RS09485	COG0477	Major facilitator Superfamily
GZK95_RS09490	COG2855	membrane
GZK95_RS09505	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GZK95_RS09510	COG2267	carboxylic ester hydrolase activity
GZK95_RS09515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GZK95_RS09520	COG1169	isochorismate synthase
GZK95_RS09525	COG0436	Aminotransferase
GZK95_RS09530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GZK95_RS09550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GZK95_RS09555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZK95_RS09570	COG1349	DNA-binding transcription factor activity
GZK95_RS09590	COG3153	acetyltransferase
GZK95_RS09595	COG3811	Belongs to the UPF0386 family
GZK95_RS09610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZK95_RS09615	COG1349	DNA-binding transcription factor activity
GZK95_RS09625	COG2222	sugar isomerase
GZK95_RS09630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS09635	COG3715	PTS system
GZK95_RS09640	COG3716	PTS system mannose fructose sorbose family IID component
GZK95_RS09645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS09660	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GZK95_RS09665	COG0616	signal peptide processing
GZK95_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
GZK95_RS09685	COG0587	DNA-directed DNA polymerase activity
GZK95_RS09690	COG0835	chemotaxis
GZK95_RS09690	COG0784	Response regulator, receiver
GZK95_RS09695	COG1940	carbohydrate kinase activity
GZK95_RS09700	COG4667	esterase of the alpha-beta hydrolase superfamily
GZK95_RS09710	COG0733	neurotransmitter:sodium symporter activity
GZK95_RS09725	COG1263	PTS System
GZK95_RS09725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS09730	COG0084	hydrolase, TatD family'
GZK95_RS09735	COG0470	DNA polymerase III
GZK95_RS09740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZK95_RS09745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GZK95_RS09775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZK95_RS09790	COG1399	metal-binding, possibly nucleic acid-binding protein
GZK95_RS09795	COG0424	maF-like protein
GZK95_RS09800	COG0564	pseudouridine synthase activity
GZK95_RS09805	COG1530	ribonuclease E activity
GZK95_RS09810	COG0659	secondary active sulfate transmembrane transporter activity
GZK95_RS09815	COG0513	Belongs to the DEAD box helicase family
GZK95_RS09820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GZK95_RS09825	COG0318	PFAM AMP-dependent synthetase and ligase
GZK95_RS09830	COG0596	Alpha beta hydrolase
GZK95_RS09845	COG1214	PFAM Peptidase M22, glycoprotease
GZK95_RS09850	COG1199	ATP-dependent helicase activity
GZK95_RS09860	COG0788	formyltetrahydrofolate deformylase activity
GZK95_RS09870	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZK95_RS09870	COG1902	pentaerythritol trinitrate reductase activity
GZK95_RS09875	COG0616	signal peptide processing
GZK95_RS09880	COG0252	asparaginase activity
GZK95_RS09885	COG3047	cAMP biosynthetic process
GZK95_RS09905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GZK95_RS09915	COG3012	SEC-C Motif Domain Protein
GZK95_RS09915	COG3318	Belongs to the UPF0149 family
GZK95_RS09925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZK95_RS09935	COG4120	Belongs to the binding-protein-dependent transport system permease family
GZK95_RS09950	COG0583	DNA-binding transcription factor activity
GZK95_RS09970	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GZK95_RS09975	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GZK95_RS10010	COG0539	negative regulation of cytoplasmic translation
GZK95_RS10015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GZK95_RS10020	COG1555	photosystem II stabilization
GZK95_RS10025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZK95_RS10030	COG0776	regulation of translation
GZK95_RS10035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GZK95_RS10040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZK95_RS10050	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZK95_RS10060	COG2204	response regulator
GZK95_RS10065	COG0748	coenzyme F420 binding
GZK95_RS10075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GZK95_RS10080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GZK95_RS10085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZK95_RS10090	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GZK95_RS10095	COG2382	esterase
GZK95_RS10105	COG0167	dihydroorotate dehydrogenase activity
GZK95_RS10115	COG2815	serine threonine protein kinase
GZK95_RS10115	COG0515	serine threonine protein kinase
GZK95_RS10130	COG0625	glutathione transferase activity
GZK95_RS10135	COG0443	Heat shock 70 kDa protein
GZK95_RS10140	COG3706	GGDEF domain
GZK95_RS10150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GZK95_RS10155	COG0784	Response regulator, receiver
GZK95_RS10155	COG5002	protein histidine kinase activity
GZK95_RS10165	COG1363	Peptidase, m42
GZK95_RS10170	COG0006	proline dipeptidase activity
GZK95_RS10175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZK95_RS10180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZK95_RS10185	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZK95_RS10190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GZK95_RS10195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GZK95_RS10205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GZK95_RS10215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZK95_RS10220	COG1012	belongs to the aldehyde dehydrogenase family
GZK95_RS10230	COG0579	oxidoreductase
GZK95_RS10245	COG0191	fructose-bisphosphate aldolase activity
GZK95_RS10265	COG1263	PTS System
GZK95_RS10265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS10265	COG2190	(PTS) system
GZK95_RS10270	COG1609	Transcriptional regulator
GZK95_RS10275	COG1114	Component of the transport system for branched-chain amino acids
GZK95_RS10290	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZK95_RS10295	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GZK95_RS10300	COG1263	PTS System
GZK95_RS10300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS10310	COG0583	DNA-binding transcription factor activity
GZK95_RS10335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZK95_RS10340	COG0583	DNA-binding transcription factor activity
GZK95_RS10345	COG2951	lytic endotransglycosylase activity
GZK95_RS10350	COG3100	YcgL domain-containing protein
GZK95_RS10355	COG0850	regulation of cytokinetic process
GZK95_RS10360	COG2894	cell division
GZK95_RS10365	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GZK95_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
GZK95_RS10370	COG1454	alcohol dehydrogenase
GZK95_RS10375	COG2095	MarC family integral membrane protein
GZK95_RS10380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZK95_RS10390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZK95_RS10395	COG1757	Na H antiporter
GZK95_RS10430	COG2204	response regulator
GZK95_RS10495	COG3082	Protein of unknown function (DUF1414)
GZK95_RS10500	COG3083	sulfuric ester hydrolase activity
GZK95_RS10520	COG0123	including yeast histone deacetylase and acetoin utilization protein
GZK95_RS10530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZK95_RS10535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GZK95_RS10555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZK95_RS10560	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GZK95_RS10570	COG2982	Protein involved in outer membrane biogenesis
GZK95_RS10575	COG0572	uridine kinase
GZK95_RS10585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZK95_RS10585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZK95_RS10615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GZK95_RS10615	COG0617	tRNA 3'-terminal CCA addition
GZK95_RS10615	COG0517	IMP dehydrogenase activity
GZK95_RS10620	COG0314	molybdopterin synthase activity
GZK95_RS10625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GZK95_RS10630	COG0315	cyclic pyranopterin monophosphate synthase activity
GZK95_RS10635	COG0521	Mo-molybdopterin cofactor biosynthetic process
GZK95_RS10640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GZK95_RS10645	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZK95_RS10650	COG2198	Histidine kinase
GZK95_RS10655	COG2204	response regulator
GZK95_RS10660	COG0556	nucleotide-excision repair
GZK95_RS10670	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GZK95_RS10675	COG4657	Part of a membrane complex involved in electron transport
GZK95_RS10685	COG4656	Part of a membrane complex involved in electron transport
GZK95_RS10700	COG4660	Part of a membrane complex involved in electron transport
GZK95_RS10705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GZK95_RS10715	COG0346	lactoylglutathione lyase activity
GZK95_RS10735	COG2056	Na+-H+ antiporter family
GZK95_RS10745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZK95_RS10755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GZK95_RS10780	COG4783	chaperone-mediated protein folding
GZK95_RS10785	COG1393	Belongs to the ArsC family
GZK95_RS10805	COG2233	PERMEase
GZK95_RS10810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZK95_RS10820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GZK95_RS10825	COG2912	Transglutaminase-like superfamily
GZK95_RS10830	COG3094	Invasion gene expression up-regulator, SirB
GZK95_RS10835	COG2890	protein-(glutamine-N5) methyltransferase activity
GZK95_RS10850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GZK95_RS10860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZK95_RS10865	COG0193	aminoacyl-tRNA hydrolase activity
GZK95_RS10975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZK95_RS10985	COG3951	Flagellar rod assembly protein muramidase FlgJ
GZK95_RS10985	COG1705	Flagellar rod assembly protein muramidase FlgJ
GZK95_RS10990	COG1706	bacterial-type flagellum-dependent cell motility
GZK95_RS10995	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GZK95_RS11005	COG4787	bacterial-type flagellum-dependent cell motility
GZK95_RS11010	COG1749	Flagellar hook protein flgE
GZK95_RS11025	COG1815	bacterial-type flagellum-dependent cell motility
GZK95_RS11030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GZK95_RS11035	COG0835	chemotaxis
GZK95_RS11035	COG0784	Response regulator, receiver
GZK95_RS11045	COG2747	anti-sigma28 factor FlgM
GZK95_RS11075	COG5002	protein histidine kinase activity
GZK95_RS11080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS11080	COG1263	PTS System
GZK95_RS11095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZK95_RS11100	COG2608	mercury ion transmembrane transporter activity
GZK95_RS11100	COG2217	Heavy metal translocating P-type atpase
GZK95_RS11115	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GZK95_RS11115	COG5479	isomerase activity
GZK95_RS11125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GZK95_RS11135	COG0326	Molecular chaperone. Has ATPase activity
GZK95_RS11140	COG3710	Transcriptional regulator
GZK95_RS11160	COG0622	Phosphoesterase
GZK95_RS11185	COG1090	epimerase
GZK95_RS11195	COG3118	belongs to the thioredoxin family
GZK95_RS11200	COG0330	HflC and HflK could
GZK95_RS11205	COG1585	Membrane protein implicated in regulation of membrane protease activity
GZK95_RS11225	COG3115	cell septum assembly
GZK95_RS11230	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GZK95_RS11235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZK95_RS11240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS11250	COG2190	(PTS) system
GZK95_RS11255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZK95_RS11265	COG1702	phosphate starvation-inducible protein PhoH
GZK95_RS11270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZK95_RS11275	COG4535	Mg2 and Co2 transporter CorC
GZK95_RS11280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GZK95_RS11285	COG2888	peptidyl-tyrosine sulfation
GZK95_RS11290	COG0495	leucyl-tRNA aminoacylation
GZK95_RS11295	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GZK95_RS11300	COG1466	dna polymerase III delta subunit
GZK95_RS11305	COG0799	negative regulation of ribosome biogenesis
GZK95_RS11310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GZK95_RS11315	COG0768	penicillin binding
GZK95_RS11320	COG0772	Belongs to the SEDS family
GZK95_RS11325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GZK95_RS11330	COG1686	Belongs to the peptidase S11 family
GZK95_RS11335	COG2921	Belongs to the UPF0250 family
GZK95_RS11345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GZK95_RS11355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZK95_RS11365	COG0366	Alpha amylase catalytic
GZK95_RS11370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS11370	COG1263	PTS System
GZK95_RS11375	COG1609	Transcriptional regulator
GZK95_RS11385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GZK95_RS11395	COG2011	ABC-type metal ion transport system permease component
GZK95_RS11400	COG1464	Belongs to the NlpA lipoprotein family
GZK95_RS11405	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GZK95_RS11415	COG0254	rRNA binding
GZK95_RS11420	COG1720	tRNA m6t6A37 methyltransferase activity
GZK95_RS11430	COG0121	glutamine amidotransferase
GZK95_RS11435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GZK95_RS11440	COG1960	acyl-CoA dehydrogenase activity
GZK95_RS11450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZK95_RS11455	COG0328	RNA-DNA hybrid ribonuclease activity
GZK95_RS11460	COG2226	methyltransferase
GZK95_RS11470	COG1388	LysM domain
GZK95_RS11470	COG0741	lytic transglycosylase activity
GZK95_RS11485	COG0347	Belongs to the P(II) protein family
GZK95_RS11500	COG0825	malonyl-CoA metabolic process
GZK95_RS11505	COG0587	DNA-directed DNA polymerase activity
GZK95_RS11515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GZK95_RS11525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZK95_RS11530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GZK95_RS11535	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GZK95_RS11540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZK95_RS11545	COG0750	zinc metalloprotease
GZK95_RS11550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZK95_RS11555	COG0575	Belongs to the CDS family
GZK95_RS11560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GZK95_RS11570	COG0528	UMP kinase activity
GZK95_RS11575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZK95_RS11585	COG0024	Methionine aminopeptidase
GZK95_RS11600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZK95_RS11630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZK95_RS11630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZK95_RS11640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GZK95_RS11660	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GZK95_RS11665	COG2252	PERMEase
GZK95_RS11670	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZK95_RS11675	COG0189	ligase activity
GZK95_RS11675	COG4067	protein conserved in archaea
GZK95_RS11680	COG0189	ligase activity
GZK95_RS11690	COG0733	neurotransmitter:sodium symporter activity
GZK95_RS11700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZK95_RS11705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZK95_RS11710	COG3706	GGDEF domain
GZK95_RS11720	COG1477	protein flavinylation
GZK95_RS11730	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GZK95_RS11745	COG1805	sodium ion transport
GZK95_RS11750	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GZK95_RS11755	COG0271	Belongs to the BolA IbaG family
GZK95_RS11760	COG2813	Specifically methylates the guanine in position
GZK95_RS11770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZK95_RS11775	COG2211	Major facilitator Superfamily
GZK95_RS11785	COG1595	DNA-templated transcription, initiation
GZK95_RS11800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GZK95_RS11805	COG0693	protein deglycase activity
GZK95_RS11810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZK95_RS11825	COG2975	iron-sulfur cluster assembly
GZK95_RS11830	COG0633	Ferredoxin
GZK95_RS11835	COG0443	Heat shock 70 kDa protein
GZK95_RS11845	COG0316	Belongs to the HesB IscA family
GZK95_RS11850	COG0822	iron-sulfur transferase activity
GZK95_RS11855	COG1104	cysteine desulfurase activity
GZK95_RS11870	COG0483	inositol monophosphate 1-phosphatase activity
GZK95_RS11915	COG0542	response to heat
GZK95_RS11925	COG0564	pseudouridine synthase activity
GZK95_RS11930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZK95_RS11940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GZK95_RS11945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZK95_RS11950	COG1605	Chorismate mutase
GZK95_RS11950	COG0077	Prephenate dehydratase
GZK95_RS11955	COG5001	Diguanylate cyclase
GZK95_RS11960	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GZK95_RS11965	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GZK95_RS11975	COG0488	(ABC) transporter
GZK95_RS11985	COG0739	heme binding
GZK95_RS11990	COG1605	Chorismate mutase
GZK95_RS11990	COG0287	Prephenate dehydrogenase
GZK95_RS12000	COG3275	phosphorelay sensor kinase activity
GZK95_RS12005	COG3279	Response regulator of the LytR AlgR family
GZK95_RS12015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GZK95_RS12020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GZK95_RS12030	COG1966	Carbon starvation protein
GZK95_RS12035	COG0612	Peptidase, M16
GZK95_RS12040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZK95_RS12045	COG1047	Peptidyl-prolyl cis-trans
GZK95_RS12055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GZK95_RS12060	COG0196	riboflavin kinase activity
GZK95_RS12065	COG0728	peptidoglycan biosynthetic process
GZK95_RS12070	COG0268	Binds directly to 16S ribosomal RNA
GZK95_RS12075	COG0640	Transcriptional regulator
GZK95_RS12080	COG0583	DNA-binding transcription factor activity
GZK95_RS12085	COG1283	sodium-dependent phosphate transmembrane transporter activity
GZK95_RS12090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GZK95_RS12100	COG0730	response to heat
GZK95_RS12115	COG3066	DNA modification
GZK95_RS12125	COG0667	Aldo Keto reductase
GZK95_RS12140	COG0784	Response regulator, receiver
GZK95_RS12140	COG2198	Histidine kinase
GZK95_RS12140	COG5002	protein histidine kinase activity
GZK95_RS12145	COG5001	Diguanylate cyclase
GZK95_RS12145	COG4251	negative regulation of phosphorylation
GZK95_RS12145	COG2203	Gaf domain
GZK95_RS12145	COG3706	GGDEF domain
GZK95_RS12150	COG1242	4 iron, 4 sulfur cluster binding
GZK95_RS12155	COG0067	glutamate synthase
GZK95_RS12155	COG0069	glutamate synthase activity
GZK95_RS12155	COG0070	glutamate synthase
GZK95_RS12170	COG0067	glutamate synthase
GZK95_RS12170	COG0069	glutamate synthase activity
GZK95_RS12170	COG0070	glutamate synthase
GZK95_RS12175	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GZK95_RS12180	COG2204	response regulator
GZK95_RS12200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GZK95_RS12205	COG0513	Belongs to the DEAD box helicase family
GZK95_RS12210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GZK95_RS12225	COG3153	acetyltransferase
GZK95_RS12230	COG3154	lipid carrier protein
GZK95_RS12240	COG0826	peptidase U32
GZK95_RS12245	COG0826	peptidase U32
GZK95_RS12250	COG0534	Mate efflux family protein
GZK95_RS12270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZK95_RS12285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZK95_RS12290	COG2860	membrane
GZK95_RS12295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GZK95_RS12300	COG0083	homoserine kinase activity
GZK95_RS12315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GZK95_RS12325	COG0745	RESPONSE REGULATOR receiver
GZK95_RS12345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZK95_RS12350	COG3025	triphosphatase activity
GZK95_RS12355	COG1392	Phosphate transport regulator
GZK95_RS12360	COG0306	phosphate transporter
GZK95_RS12365	COG4991	sh3 domain protein
GZK95_RS12375	COG3267	Type II secretory pathway component ExeA
GZK95_RS12375	COG3409	Peptidoglycan-binding domain 1 protein
GZK95_RS12385	COG0148	phosphopyruvate hydratase activity
GZK95_RS12390	COG0504	CTP synthase activity
GZK95_RS12395	COG3956	TIGRFAM MazG family protein
GZK95_RS12400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZK95_RS12420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GZK95_RS12425	COG1381	Involved in DNA repair and RecF pathway recombination
GZK95_RS12430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZK95_RS12450	COG3086	response to oxidative stress
GZK95_RS12465	COG1595	DNA-templated transcription, initiation
GZK95_RS12470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GZK95_RS12480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GZK95_RS12500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZK95_RS12505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZK95_RS12525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GZK95_RS12530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GZK95_RS12535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZK95_RS12545	COG0028	Belongs to the TPP enzyme family
GZK95_RS12550	COG1022	Amp-dependent synthetase and ligase
GZK95_RS12555	COG0583	DNA-binding transcription factor activity
GZK95_RS12570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZK95_RS12575	COG0473	3-isopropylmalate dehydrogenase activity
GZK95_RS12630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GZK95_RS12640	COG1609	Transcriptional regulator
GZK95_RS12650	COG1486	melibiose metabolic process
GZK95_RS12655	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZK95_RS12660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZK95_RS12685	COG1301	dicarboxylic acid transport
GZK95_RS12690	COG0626	cystathionine gamma-synthase activity
GZK95_RS12705	COG1854	S-ribosylhomocysteine lyase activity
GZK95_RS12720	COG0612	Peptidase, M16
GZK95_RS12725	COG1238	metal cluster binding
GZK95_RS12735	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GZK95_RS12740	COG5016	pyruvate
GZK95_RS12740	COG0511	ligase activity, forming carbon-carbon bonds
GZK95_RS12745	COG3630	sodium ion export across plasma membrane
GZK95_RS12800	COG0527	aspartate kinase activity
GZK95_RS12805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZK95_RS12815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZK95_RS12820	COG1546	Belongs to the CinA family
GZK95_RS12825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GZK95_RS12830	COG4969	Belongs to the N-Me-Phe pilin family
GZK95_RS12835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GZK95_RS12840	COG1459	type II secretion system
GZK95_RS12845	COG1459	type II secretion system
GZK95_RS12855	COG0237	dephospho-CoA kinase activity
GZK95_RS12860	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GZK95_RS12865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GZK95_RS12870	COG0335	large ribosomal subunit rRNA binding
GZK95_RS12890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZK95_RS12895	COG4137	Cytochrome C assembly protein
GZK95_RS12900	COG4536	flavin adenine dinucleotide binding
GZK95_RS12905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZK95_RS12925	COG0585	pseudouridine synthase activity
GZK95_RS12935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZK95_RS12940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GZK95_RS12950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZK95_RS12955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GZK95_RS12960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZK95_RS12970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZK95_RS12975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GZK95_RS12980	COG1610	YqeY-like protein
GZK95_RS12985	COG0358	DNA primase activity
GZK95_RS13075	COG2252	PERMEase
GZK95_RS13085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GZK95_RS13090	COG2213	PTS system mannitol-specific
GZK95_RS13090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS13100	COG3722	fumarate hydratase activity
GZK95_RS13105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZK95_RS13115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GZK95_RS13120	COG1349	DNA-binding transcription factor activity
GZK95_RS13125	COG0469	pyruvate kinase activity
GZK95_RS13145	COG1279	arginine transmembrane transporter activity
GZK95_RS13150	COG0668	transmembrane transport
GZK95_RS13155	COG0191	fructose-bisphosphate aldolase activity
GZK95_RS13160	COG0126	phosphoglycerate kinase activity
GZK95_RS13165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZK95_RS13175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GZK95_RS13180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZK95_RS13195	COG2356	endonuclease I
GZK95_RS13200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZK95_RS13205	COG0189	ligase activity
GZK95_RS13210	COG1678	Uncharacterized ACR, COG1678
GZK95_RS13215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GZK95_RS13220	COG0312	modulator of DNA gyrase
GZK95_RS13225	COG3028	Belongs to the UPF0307 family
GZK95_RS13230	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GZK95_RS13235	COG1178	ABC-type Fe3 transport system permease component
GZK95_RS13240	COG4143	(ABC) transporter
GZK95_RS13245	COG0163	prenyltransferase activity
GZK95_RS13250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZK95_RS13255	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GZK95_RS13260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GZK95_RS13270	COG2105	PFAM AIG2 family protein
GZK95_RS13275	COG2911	Protein conserved in bacteria
GZK95_RS13280	COG0729	surface antigen
GZK95_RS13285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZK95_RS13290	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GZK95_RS13330	COG0432	Pfam Uncharacterised protein family UPF0047
GZK95_RS13340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GZK95_RS13345	COG0305	Participates in initiation and elongation during chromosome replication
GZK95_RS13365	COG2965	DNA replication, synthesis of RNA primer
GZK95_RS13375	COG2194	sulfuric ester hydrolase activity
GZK95_RS13380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GZK95_RS13390	COG2906	2 iron, 2 sulfur cluster binding
GZK95_RS13400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZK95_RS13405	COG0049	tRNA binding
GZK95_RS13420	COG2923	Belongs to the DsrF TusC family
GZK95_RS13425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GZK95_RS13430	COG2964	Protein conserved in bacteria
GZK95_RS13435	COG0545	Peptidyl-prolyl cis-trans isomerase
GZK95_RS13450	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GZK95_RS13455	COG0330	HflC and HflK could
GZK95_RS13460	COG0330	HflC and HflK could
GZK95_RS13465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZK95_RS13480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZK95_RS13490	COG0802	atpase or kinase
GZK95_RS13495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GZK95_RS13560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GZK95_RS13565	COG1162	GTPase activity
GZK95_RS13570	COG0688	phosphatidylethanolamine metabolic process
GZK95_RS13575	COG3273	potassium ion transport
GZK95_RS13575	COG0471	metal ion transport
GZK95_RS13590	COG4942	peptidase
GZK95_RS13615	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GZK95_RS13620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZK95_RS13625	COG0085	RNA polymerase activity
GZK95_RS13640	COG0081	regulation of translation
GZK95_RS13650	COG0250	Participates in transcription elongation, termination and antitermination
GZK95_RS13655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZK95_RS13685	COG1072	(Pantothenic acid kinase))
GZK95_RS13700	COG0149	triose-phosphate isomerase activity
GZK95_RS13705	COG0534	Mate efflux family protein
GZK95_RS13710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GZK95_RS13715	COG1575	Belongs to the MenA family. Type 1 subfamily
GZK95_RS13725	COG1509	lysine 2,3-aminomutase activity
GZK95_RS13750	COG0745	RESPONSE REGULATOR receiver
GZK95_RS13755	COG2205	protein histidine kinase activity
GZK95_RS13765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GZK95_RS13775	COG3706	GGDEF domain
GZK95_RS13780	COG1027	Aspartate ammonia-lyase
GZK95_RS13785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GZK95_RS13790	COG4232	protein-disulfide reductase activity
GZK95_RS13800	COG2095	MarC family integral membrane protein
GZK95_RS13810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZK95_RS13820	COG2205	protein histidine kinase activity
GZK95_RS13820	COG2198	Histidine kinase
GZK95_RS13820	COG0784	Response regulator, receiver
GZK95_RS13825	COG2814	Major facilitator Superfamily
GZK95_RS13840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZK95_RS13845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GZK95_RS13850	COG0511	ligase activity, forming carbon-carbon bonds
GZK95_RS13855	COG0439	Biotin carboxylase
GZK95_RS13860	COG2264	protein methyltransferase activity
GZK95_RS13870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GZK95_RS13880	COG3706	GGDEF domain
GZK95_RS13885	COG0789	Transcriptional regulator
GZK95_RS13890	COG0138	bifunctional purine biosynthesis protein purh
GZK95_RS13895	COG0151	Belongs to the GarS family
GZK95_RS13910	COG1253	flavin adenine dinucleotide binding
GZK95_RS13920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZK95_RS13925	COG1573	uracil-dna glycosylase
GZK95_RS13990	COG4206	TonB-dependent receptor
GZK95_RS14010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZK95_RS14020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZK95_RS14025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GZK95_RS14030	COG2937	Belongs to the GPAT DAPAT family
GZK95_RS14040	COG3161	chorismate lyase activity
GZK95_RS14045	COG1580	Controls the rotational direction of flagella during chemotaxis
GZK95_RS14050	COG0705	Rhomboid family
GZK95_RS14065	COG2177	Part of the ABC transporter FtsEX involved in
GZK95_RS14070	COG2884	Cell division ATP-binding protein ftsE
GZK95_RS14075	COG0552	protein localization to endoplasmic reticulum
GZK95_RS14080	COG0742	ribosomal rna small subunit methyltransferase
GZK95_RS14090	COG2095	MarC family integral membrane protein
GZK95_RS14130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZK95_RS14135	COG0640	Transcriptional regulator
GZK95_RS14140	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GZK95_RS14145	COG1280	lysine exporter protein (LysE YggA)
GZK95_RS14150	COG2267	carboxylic ester hydrolase activity
GZK95_RS14155	COG0561	phosphatase activity
GZK95_RS14175	COG1011	Hydrolase
GZK95_RS14180	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GZK95_RS14190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GZK95_RS14195	COG0019	diaminopimelate decarboxylase activity
GZK95_RS14205	COG1965	Belongs to the frataxin family
GZK95_RS14215	COG0181	hydroxymethylbilane synthase activity
GZK95_RS14220	COG1587	Uroporphyrinogen-III synthase
GZK95_RS14225	COG2959	enzyme of heme biosynthesis
GZK95_RS14230	COG3071	HemY protein
GZK95_RS14325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GZK95_RS14340	COG3118	belongs to the thioredoxin family
GZK95_RS14350	COG0248	Ppx GppA phosphatase
GZK95_RS14355	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GZK95_RS14365	COG0514	ATP-dependent DNA helicase (RecQ)
GZK95_RS14370	COG2962	Rard protein
GZK95_RS14380	COG1280	lysine exporter protein (LysE YggA)
GZK95_RS14385	COG0210	DNA helicase
GZK95_RS14395	COG3220	belongs to the UPF0276 family
GZK95_RS14410	COG0339	signal peptide processing
GZK95_RS14415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GZK95_RS14420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZK95_RS14425	COG0840	transmembrane signaling receptor activity
GZK95_RS14445	COG2194	sulfuric ester hydrolase activity
GZK95_RS14450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZK95_RS14460	COG0747	negative chemotaxis
GZK95_RS14505	COG1309	transcriptional regulator
GZK95_RS14510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS14515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZK95_RS14520	COG2960	long-chain fatty acid transporting porin activity
GZK95_RS14525	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GZK95_RS14530	COG0583	DNA-binding transcription factor activity
GZK95_RS14565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZK95_RS14565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZK95_RS14575	COG0084	hydrolase, TatD family'
GZK95_RS14580	COG0805	protein transport
GZK95_RS14585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZK95_RS14595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZK95_RS14605	COG2226	methyltransferase
GZK95_RS14610	COG1322	Protein conserved in bacteria
GZK95_RS14620	COG3265	gluconokinase activity
GZK95_RS14625	COG0129	dihydroxy-acid dehydratase activity
GZK95_RS14630	COG1609	Transcriptional regulator
GZK95_RS14635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GZK95_RS14645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GZK95_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
GZK95_RS14660	COG0800	Aldolase
GZK95_RS14665	COG2081	HI0933 family
GZK95_RS14675	COG1528	Iron-storage protein
GZK95_RS14680	COG0589	response to stress
GZK95_RS14695	COG0742	ribosomal rna small subunit methyltransferase
GZK95_RS14700	COG5001	Diguanylate cyclase
GZK95_RS14700	COG5002	protein histidine kinase activity
GZK95_RS14705	COG1522	sequence-specific DNA binding
GZK95_RS14715	COG2814	Major facilitator Superfamily
GZK95_RS14725	COG0006	proline dipeptidase activity
GZK95_RS14725	COG0006	proline dipeptidase activity
GZK95_RS14730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GZK95_RS14735	COG2022	thiamine diphosphate biosynthetic process
GZK95_RS14745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GZK95_RS14750	COG0352	thiamine-phosphate diphosphorylase activity
GZK95_RS14815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZK95_RS14820	COG1739	Uncharacterized protein family UPF0029
GZK95_RS14830	COG0183	Belongs to the thiolase family
GZK95_RS14835	COG0583	DNA-binding transcription factor activity
GZK95_RS14840	COG2814	Major facilitator Superfamily
GZK95_RS14845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZK95_RS14850	COG0765	amino acid transport
GZK95_RS14860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZK95_RS14865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZK95_RS14870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZK95_RS14880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZK95_RS14885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GZK95_RS14900	COG3312	ion transport
GZK95_RS14905	COG1475	DNA binding
GZK95_RS14910	COG1192	Involved in chromosome partitioning
GZK95_RS14915	COG0357	Ribosomal RNA small subunit methyltransferase G
GZK95_RS14920	COG0445	tRNA wobble uridine modification
GZK95_RS14940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZK95_RS14945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZK95_RS14950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZK95_RS14955	COG1116	anion transmembrane transporter activity
GZK95_RS14960	COG0351	phosphomethylpyrimidine kinase
GZK95_RS14970	COG4608	Belongs to the ABC transporter superfamily
GZK95_RS14975	COG0444	Belongs to the ABC transporter superfamily
GZK95_RS14990	COG0217	transcriptional regulatory protein
GZK95_RS15000	COG1566	PFAM secretion protein HlyD family protein
GZK95_RS15035	COG2197	response regulator
GZK95_RS15065	COG0814	amino acid
GZK95_RS15070	COG0753	catalase activity
GZK95_RS15075	COG0434	BtpA family
GZK95_RS15080	COG1879	ABC-type sugar transport system periplasmic component
GZK95_RS15085	COG1129	ABC transporter
GZK95_RS15090	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZK95_RS15105	COG1070	Carbohydrate kinase
GZK95_RS15110	COG1349	DNA-binding transcription factor activity
GZK95_RS15115	COG0583	DNA-binding transcription factor activity
GZK95_RS15135	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GZK95_RS15140	COG0372	Belongs to the citrate synthase family
GZK95_RS15150	COG2828	Protein conserved in bacteria
GZK95_RS15160	COG2186	Transcriptional regulator
GZK95_RS15175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GZK95_RS15180	COG4948	Mandelate Racemase Muconate Lactonizing
GZK95_RS15185	COG0246	Mannitol dehydrogenase
GZK95_RS15190	COG1904	glucuronate isomerase
GZK95_RS15195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS15210	COG2130	NADP-dependent
GZK95_RS15215	COG1309	transcriptional regulator
GZK95_RS15255	COG0561	phosphatase activity
GZK95_RS15265	COG1280	lysine exporter protein (LysE YggA)
GZK95_RS15305	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZK95_RS15315	COG2226	methyltransferase
GZK95_RS15325	COG1858	cytochrome C peroxidase
GZK95_RS15330	COG2871	sodium ion transport
GZK95_RS15340	COG1129	ABC transporter
GZK95_RS15345	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZK95_RS15355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GZK95_RS15360	COG0612	Peptidase, M16
GZK95_RS15365	COG4178	(ABC) transporter
GZK95_RS15370	COG4771	TonB-dependent receptor
GZK95_RS15380	COG0811	peptide transport
GZK95_RS15385	COG0811	peptide transport
GZK95_RS15390	COG0848	biopolymer transport protein
GZK95_RS15405	COG2723	6-phospho-beta-galactosidase activity
GZK95_RS15410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS15410	COG1263	PTS System
GZK95_RS15440	COG0840	transmembrane signaling receptor activity
GZK95_RS15455	COG2909	trisaccharide binding
GZK95_RS15460	COG0058	SHG alpha-glucan phosphorylase activity
GZK95_RS15465	COG1640	4-alpha-glucanotransferase
GZK95_RS15470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GZK95_RS15475	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GZK95_RS15495	COG0596	Alpha beta hydrolase
GZK95_RS15500	COG0471	metal ion transport
GZK95_RS15510	COG0251	oxidation-reduction process
GZK95_RS15515	COG0010	Belongs to the arginase family
GZK95_RS15520	COG1166	arginine decarboxylase activity
GZK95_RS15535	COG1882	Formate acetyltransferase
GZK95_RS15560	COG0513	Belongs to the DEAD box helicase family
GZK95_RS15565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZK95_RS15570	COG3366	ferrous iron transmembrane transporter activity
GZK95_RS15575	COG0700	Nucleoside recognition
GZK95_RS15585	COG4565	transcriptional regulatory protein
GZK95_RS15590	COG3290	protein histidine kinase activity
GZK95_RS15595	COG0471	metal ion transport
GZK95_RS15600	COG3706	GGDEF domain
GZK95_RS15605	COG3339	Conserved Protein
GZK95_RS15610	COG1301	dicarboxylic acid transport
GZK95_RS15615	COG1671	Belongs to the UPF0178 family
GZK95_RS15635	COG0318	PFAM AMP-dependent synthetase and ligase
GZK95_RS15670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZK95_RS15685	COG0363	glucosamine-6-phosphate deaminase activity
GZK95_RS15695	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GZK95_RS15700	COG1162	GTPase activity
GZK95_RS15710	COG1999	signal sequence binding
GZK95_RS15725	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GZK95_RS15730	COG2274	protein secretion by the type I secretion system
GZK95_RS15750	COG0259	pyridoxamine-phosphate oxidase activity
GZK95_RS15760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GZK95_RS15785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZK95_RS15800	COG1051	belongs to the nudix hydrolase family
GZK95_RS15810	COG1132	(ABC) transporter
GZK95_RS15835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZK95_RS15850	COG1122	ATPase activity
GZK95_RS15855	COG4720	Psort location CytoplasmicMembrane, score
GZK95_RS15860	COG1566	PFAM secretion protein HlyD family protein
GZK95_RS15870	COG3706	GGDEF domain
GZK95_RS15885	COG0813	purine-nucleoside phosphorylase activity
GZK95_RS15890	COG3272	Protein of unknown function (DUF1722)
GZK95_RS15895	COG0789	Transcriptional regulator
GZK95_RS15900	COG0415	Belongs to the DNA photolyase family
GZK95_RS15905	COG1376	ErfK ybiS ycfS ynhG family protein
GZK95_RS15905	COG1388	LysM domain
GZK95_RS15910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZK95_RS15925	COG0583	DNA-binding transcription factor activity
GZK95_RS15935	COG0842	Transport permease protein
GZK95_RS15940	COG1131	(ABC) transporter
GZK95_RS15970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZK95_RS15975	COG2084	Dehydrogenase
GZK95_RS15985	COG0513	Belongs to the DEAD box helicase family
GZK95_RS15995	COG4948	Mandelate Racemase Muconate Lactonizing
GZK95_RS16000	COG1053	succinate dehydrogenase
GZK95_RS16000	COG3976	FMN-binding domain protein
GZK95_RS16005	COG1802	Transcriptional regulator
GZK95_RS16035	COG0739	heme binding
GZK95_RS16040	COG1304	FMN binding
GZK95_RS16060	COG0625	glutathione transferase activity
GZK95_RS16080	COG1881	PFAM PEBP family protein
GZK95_RS16090	COG1902	pentaerythritol trinitrate reductase activity
GZK95_RS16095	COG0346	lactoylglutathione lyase activity
GZK95_RS16105	COG0772	Belongs to the SEDS family
GZK95_RS16110	COG3842	ATPase activity
GZK95_RS16120	COG1840	ABC-type Fe3 transport system, periplasmic component
GZK95_RS16125	COG2271	Major facilitator Superfamily
GZK95_RS16130	COG3851	Histidine kinase
GZK95_RS16135	COG2197	response regulator
GZK95_RS16140	COG2814	Major facilitator Superfamily
GZK95_RS16155	COG0840	transmembrane signaling receptor activity
GZK95_RS16165	COG0814	amino acid
GZK95_RS16185	COG1522	sequence-specific DNA binding
GZK95_RS16190	COG2423	ornithine cyclodeaminase activity
GZK95_RS16195	COG0667	Aldo Keto reductase
GZK95_RS16205	COG1522	sequence-specific DNA binding
GZK95_RS16215	COG3976	FMN-binding domain protein
GZK95_RS16215	COG1053	succinate dehydrogenase
GZK95_RS16215	COG0431	NADPH-dependent FMN reductase
GZK95_RS16225	COG1335	isochorismatase
GZK95_RS16285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZK95_RS16290	COG1917	Cupin 2, conserved barrel domain protein
GZK95_RS16290	COG4977	sequence-specific DNA binding
GZK95_RS16310	COG0509	glycine decarboxylation via glycine cleavage system
GZK95_RS16315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZK95_RS16325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GZK95_RS16340	COG3710	Transcriptional regulator
GZK95_RS16350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZK95_RS16375	COG0697	spore germination
GZK95_RS16395	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZK95_RS16410	COG3604	Transcriptional regulator
GZK95_RS16415	COG1017	nitric oxide dioxygenase activity
GZK95_RS16415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZK95_RS16420	COG0418	dihydroorotase activity
GZK95_RS16425	COG3217	Mosc domain protein beta barrel domain protein
GZK95_RS16425	COG0633	Ferredoxin
GZK95_RS16445	COG1757	Na H antiporter
GZK95_RS16465	COG1744	ABC transporter substrate-binding protein PnrA-like
GZK95_RS16475	COG1121	(ABC) transporter
GZK95_RS16480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZK95_RS16490	COG0523	cobalamin synthesis protein
GZK95_RS16495	COG3683	transport system, periplasmic component
GZK95_RS16500	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GZK95_RS16555	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GZK95_RS16555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GZK95_RS16560	COG0516	GMP reductase activity
GZK95_RS16570	COG1473	amidohydrolase
GZK95_RS16580	COG0006	proline dipeptidase activity
GZK95_RS16585	COG2964	Protein conserved in bacteria
GZK95_RS16590	COG0251	oxidation-reduction process
GZK95_RS16595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GZK95_RS16625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS16635	COG3437	response regulator, receiver
GZK95_RS16660	COG1902	pentaerythritol trinitrate reductase activity
GZK95_RS16675	COG0640	Transcriptional regulator
GZK95_RS16705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZK95_RS16710	COG1979	alcohol dehydrogenase
GZK95_RS16715	COG0697	spore germination
GZK95_RS16720	COG2176	DNA-directed DNA polymerase activity
GZK95_RS16725	COG0517	IMP dehydrogenase activity
GZK95_RS16730	COG2186	Transcriptional regulator
GZK95_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
GZK95_RS16740	COG2186	Transcriptional regulator
GZK95_RS16760	COG3181	Tripartite tricarboxylate transporter family receptor
GZK95_RS16780	COG1917	Cupin 2, conserved barrel domain protein
GZK95_RS16785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZK95_RS16790	COG0800	Aldolase
GZK95_RS16795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZK95_RS16800	COG1609	Transcriptional regulator
GZK95_RS16805	COG4948	Mandelate Racemase Muconate Lactonizing
GZK95_RS16820	COG2207	Transcriptional regulator
GZK95_RS16825	COG1979	alcohol dehydrogenase
GZK95_RS16845	COG2376	Dihydroxyacetone kinase
GZK95_RS16850	COG1461	Dihydroxyacetone kinase
GZK95_RS16855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZK95_RS16860	COG3284	Transcriptional regulator
GZK95_RS16885	COG3706	GGDEF domain
GZK95_RS16905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZK95_RS16930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZK95_RS16950	COG2208	phosphoserine phosphatase activity
GZK95_RS16955	COG1366	Belongs to the anti-sigma-factor antagonist family
GZK95_RS16960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GZK95_RS16995	COG1879	ABC-type sugar transport system periplasmic component
GZK95_RS17000	COG1129	ABC transporter
GZK95_RS17005	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZK95_RS17010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZK95_RS17015	COG1940	carbohydrate kinase activity
GZK95_RS17020	COG1737	Transcriptional regulator
GZK95_RS17060	COG3186	Phenylalanine-4-hydroxylase
GZK95_RS17075	COG1011	Hydrolase
GZK95_RS17080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZK95_RS17100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GZK95_RS17100	COG2199	diguanylate cyclase activity
GZK95_RS17120	COG3104	oligopeptide transport
GZK95_RS17125	COG1760	l-serine dehydratase
GZK95_RS17140	COG3706	GGDEF domain
GZK95_RS17145	COG0835	chemotaxis
GZK95_RS17145	COG0784	Response regulator, receiver
GZK95_RS17150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZK95_RS17160	COG1560	Kdo2-lipid A biosynthetic process
GZK95_RS17170	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GZK95_RS17190	COG0697	spore germination
GZK95_RS17195	COG1846	Transcriptional regulator
GZK95_RS17200	COG2315	Protein conserved in bacteria
GZK95_RS17250	COG2995	paraquat-inducible protein a
GZK95_RS17255	COG3008	intermembrane lipid transfer
GZK95_RS17255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GZK95_RS17280	COG3118	belongs to the thioredoxin family
GZK95_RS17285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZK95_RS17290	COG0420	3'-5' exonuclease activity
GZK95_RS17295	COG0419	ATPase involved in DNA repair
GZK95_RS17300	COG0784	Response regulator, receiver
GZK95_RS17300	COG2205	protein histidine kinase activity
GZK95_RS17315	COG0523	cobalamin synthesis protein
GZK95_RS17410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GZK95_RS17415	COG0363	glucosamine-6-phosphate deaminase activity
GZK95_RS17420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GZK95_RS17440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZK95_RS17440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZK95_RS17445	COG2226	methyltransferase
GZK95_RS17450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GZK95_RS17455	COG0469	pyruvate kinase activity
GZK95_RS17460	COG2271	Major facilitator Superfamily
GZK95_RS17470	COG4191	Histidine kinase
GZK95_RS17490	COG4607	ABC-type enterochelin transport system periplasmic component
GZK95_RS17510	COG3119	arylsulfatase activity
GZK95_RS17515	COG3119	arylsulfatase activity
GZK95_RS17525	COG0714	Associated with various cellular activities
GZK95_RS17555	COG0583	DNA-binding transcription factor activity
GZK95_RS17560	COG3111	PFAM Bacterial OB fold (BOF) protein
GZK95_RS17575	COG0641	radical SAM
GZK95_RS17600	COG3706	GGDEF domain
GZK95_RS17605	COG2814	Major facilitator Superfamily
GZK95_RS17610	COG0583	DNA-binding transcription factor activity
GZK95_RS17650	COG0438	transferase activity, transferring glycosyl groups
GZK95_RS17660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GZK95_RS17675	COG0463	Glycosyl transferase, family 2
GZK95_RS17695	COG0519	Catalyzes the synthesis of GMP from XMP
GZK95_RS17820	COG5492	domain, Protein
GZK95_RS17820	COG4932	domain protein
GZK95_RS17830	COG5492	domain, Protein
GZK95_RS17850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GZK95_RS17925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZK95_RS17935	COG0745	RESPONSE REGULATOR receiver
GZK95_RS17960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZK95_RS17985	COG1022	Amp-dependent synthetase and ligase
GZK95_RS18025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GZK95_RS18030	COG1263	PTS System
GZK95_RS18030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZK95_RS18065	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GZK95_RS18070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GZK95_RS18075	COG1960	acyl-CoA dehydrogenase activity
GZK95_RS18085	COG0183	Belongs to the thiolase family
GZK95_RS18095	COG1960	acyl-CoA dehydrogenase activity
GZK95_RS18100	COG1024	Enoyl-CoA hydratase
GZK95_RS18115	COG1028	Short-chain dehydrogenase reductase Sdr
GZK95_RS18125	COG0494	nUDIX hydrolase
GZK95_RS18140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZK95_RS18145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZK95_RS18150	COG1780	Probably involved in ribonucleotide reductase function
GZK95_RS18160	COG0316	Belongs to the HesB IscA family
GZK95_RS18165	COG0719	Fe-S assembly protein
GZK95_RS18170	COG0396	ATPase activity
GZK95_RS18175	COG0719	Fe-S assembly protein
GZK95_RS18185	COG2166	iron-sulfur cluster assembly
GZK95_RS18200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZK95_RS18205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZK95_RS18220	COG3437	response regulator, receiver
GZK95_RS18220	COG0784	Response regulator, receiver
GZK95_RS18225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZK95_RS18245	COG0484	heat shock protein binding
GZK95_RS18255	COG3300	MHYT domain
GZK95_RS18255	COG5001	Diguanylate cyclase
GZK95_RS18260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZK95_RS18270	COG4181	ATPase activity
GZK95_RS18275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GZK95_RS18285	COG1984	allophanate hydrolase subunit 2
GZK95_RS18290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GZK95_RS18295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GZK95_RS18300	COG3069	C4-dicarboxylate transmembrane transporter activity
GZK95_RS18320	COG3038	cytochrome b561
GZK95_RS18325	COG2353	YceI-like domain
GZK95_RS18330	COG2116	formate transmembrane transporter activity
GZK95_RS18335	COG0583	DNA-binding transcription factor activity
GZK95_RS18345	COG3593	DNA synthesis involved in DNA repair
GZK95_RS18350	COG0737	Belongs to the 5'-nucleotidase family
GZK95_RS18375	COG0840	transmembrane signaling receptor activity
GZK95_RS18380	COG2824	Alkylphosphonate utilization operon protein PhnA
GZK95_RS18395	COG2050	protein possibly involved in aromatic compounds catabolism
GZK95_RS18405	COG4533	DNA binding
GZK95_RS18415	COG0583	DNA-binding transcription factor activity
GZK95_RS18420	COG0045	succinate-CoA ligase (ADP-forming) activity
GZK95_RS18420	COG1042	CoA-binding domain protein
GZK95_RS18420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZK95_RS18430	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZK95_RS18445	COG0023	Translation Initiation Factor
GZK95_RS18450	COG1454	alcohol dehydrogenase
GZK95_RS18570	COG2801	Transposase and inactivated derivatives
GZK95_RS18595	COG3140	Belongs to the UPF0181 family
GZK95_RS18610	COG0745	RESPONSE REGULATOR receiver
GZK95_RS18620	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GZK95_RS18625	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GZK95_RS18640	COG2199	diguanylate cyclase activity
GZK95_RS18650	COG3706	GGDEF domain
GZK95_RS18650	COG5001	Diguanylate cyclase
GZK95_RS18650	COG2203	Gaf domain
GZK95_RS18650	COG4251	negative regulation of phosphorylation
GZK95_RS18660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GZK95_RS18665	COG4149	molybdate abc transporter
GZK95_RS18670	COG0725	ABC transporter, periplasmic molybdate-binding protein
GZK95_RS18675	COG1492	cobalamin metabolic process
GZK95_RS18700	COG1609	Transcriptional regulator
GZK95_RS18705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS18705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS18710	COG1105	Belongs to the carbohydrate kinase PfkB family
GZK95_RS18715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS18715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS18715	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GZK95_RS18720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZK95_RS18725	COG1979	alcohol dehydrogenase
GZK95_RS18735	COG2205	protein histidine kinase activity
GZK95_RS18735	COG0784	Response regulator, receiver
GZK95_RS18735	COG2198	Histidine kinase
GZK95_RS18740	COG1879	ABC-type sugar transport system periplasmic component
GZK95_RS18745	COG1803	Methylglyoxal synthase
GZK95_RS18750	COG0210	DNA helicase
GZK95_RS18755	COG1289	transmembrane transporter activity
GZK95_RS18775	COG5002	protein histidine kinase activity
GZK95_RS18775	COG0784	Response regulator, receiver
GZK95_RS18780	COG1879	ABC-type sugar transport system periplasmic component
GZK95_RS18810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GZK95_RS18830	COG0545	Peptidyl-prolyl cis-trans isomerase
GZK95_RS18835	COG0189	ligase activity
GZK95_RS18835	COG4067	protein conserved in archaea
GZK95_RS18850	COG0602	queuosine metabolic process
GZK95_RS18855	COG1328	CTP reductase activity
GZK95_RS18880	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZK95_RS18895	COG3040	lipid binding
GZK95_RS18910	COG0183	Belongs to the thiolase family
GZK95_RS18935	COG1309	transcriptional regulator
GZK95_RS18940	COG0513	Belongs to the DEAD box helicase family
GZK95_RS18950	COG0814	amino acid
GZK95_RS18960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZK95_RS18965	COG1846	Transcriptional regulator
GZK95_RS18975	COG2814	Major facilitator Superfamily
GZK95_RS19005	COG0277	FAD linked oxidase domain protein
GZK95_RS19010	COG0513	Belongs to the DEAD box helicase family
GZK95_RS19015	COG0302	gtp cyclohydrolase
GZK95_RS19025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GZK95_RS19035	COG2897	thiosulfate sulfurtransferase activity
GZK95_RS19045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GZK95_RS19050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GZK95_RS19060	COG3850	Histidine kinase
GZK95_RS19060	COG4999	Histidine kinase
GZK95_RS19060	COG3437	response regulator, receiver
GZK95_RS19060	COG2205	protein histidine kinase activity
GZK95_RS19075	COG2824	Alkylphosphonate utilization operon protein PhnA
GZK95_RS19105	COG2301	Belongs to the HpcH HpaI aldolase family
GZK95_RS19115	COG4565	transcriptional regulatory protein
GZK95_RS19120	COG3290	protein histidine kinase activity
GZK95_RS19125	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GZK95_RS19130	COG0511	ligase activity, forming carbon-carbon bonds
GZK95_RS19130	COG5016	pyruvate
GZK95_RS19145	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GZK95_RS19190	COG1012	belongs to the aldehyde dehydrogenase family
GZK95_RS19200	COG0784	Response regulator, receiver
GZK95_RS19200	COG2205	protein histidine kinase activity
GZK95_RS19235	COG5001	Diguanylate cyclase
GZK95_RS19235	COG3300	MHYT domain
GZK95_RS19240	COG3122	Protein conserved in bacteria
GZK95_RS19245	COG0513	Belongs to the DEAD box helicase family
GZK95_RS19250	COG2885	chlorophyll binding
GZK95_RS19300	COG4964	Belongs to the GSP D family
GZK95_RS19330	COG0583	DNA-binding transcription factor activity
GZK95_RS19335	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZK95_RS19345	COG2207	Transcriptional regulator
GZK95_RS19365	COG1805	sodium ion transport
GZK95_RS19370	COG1271	oxidase subunit
GZK95_RS19375	COG1294	oxidase, subunit
GZK95_RS19405	COG0330	HflC and HflK could
GZK95_RS19415	COG1288	antiporter activity
GZK95_RS19420	COG0527	aspartate kinase activity
GZK95_RS19425	COG0662	Cupin 2, conserved barrel domain protein
GZK95_RS19430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GZK95_RS19435	COG0456	acetyltransferase
GZK95_RS19440	COG3706	GGDEF domain
GZK95_RS19445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZK95_RS19450	COG0789	Transcriptional regulator
GZK95_RS19455	COG4604	ABC transporter, ATP-binding protein
GZK95_RS19460	COG4605	iron ion homeostasis
GZK95_RS19465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZK95_RS19470	COG4607	ABC-type enterochelin transport system periplasmic component
GZK95_RS19480	COG2203	Gaf domain
GZK95_RS19480	COG3706	GGDEF domain
GZK95_RS19480	COG4251	negative regulation of phosphorylation
GZK95_RS19480	COG5001	Diguanylate cyclase
GZK95_RS19485	COG4172	Belongs to the ABC transporter superfamily
GZK95_RS19490	COG4239	(ABC) transporter, permease
GZK95_RS19495	COG4174	ABC transporter (Permease)
GZK95_RS19500	COG4166	transmembrane transport
GZK95_RS19510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZK95_RS19515	COG1067	ATP-dependent peptidase activity
GZK95_RS19525	COG4172	Belongs to the ABC transporter superfamily
GZK95_RS19530	COG0583	DNA-binding transcription factor activity
GZK95_RS19535	COG1620	l-lactate permease
GZK95_RS19555	COG0798	PFAM Bile acid sodium symporter
GZK95_RS19560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZK95_RS19580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZK95_RS19595	COG1683	Conserved Protein
GZK95_RS19610	COG2197	response regulator
GZK95_RS19615	COG3851	Histidine kinase
GZK95_RS19620	COG2271	Major facilitator Superfamily
GZK95_RS19650	COG0156	8-amino-7-oxononanoate synthase activity
GZK95_RS19660	COG1794	racemase activity, acting on amino acids and derivatives
GZK95_RS19695	COG0367	asparagine synthase
GZK95_RS19700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZK95_RS19705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZK95_RS19710	COG0581	inorganic phosphate transmembrane transporter activity
GZK95_RS19715	COG0573	inorganic phosphate transmembrane transporter activity
GZK95_RS19725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS19730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS19740	COG2207	Transcriptional regulator
GZK95_RS19745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS19745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS19745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS19750	COG1482	cell wall glycoprotein biosynthetic process
GZK95_RS19765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS19810	COG0714	Associated with various cellular activities
GZK95_RS19830	COG2304	oxidoreductase activity
GZK95_RS19850	COG1765	OsmC-like protein
GZK95_RS19855	COG0673	inositol 2-dehydrogenase activity
GZK95_RS19870	COG1522	sequence-specific DNA binding
GZK95_RS19875	COG0531	amino acid
GZK95_RS19905	COG2205	protein histidine kinase activity
GZK95_RS19905	COG0784	Response regulator, receiver
GZK95_RS19910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZK95_RS19920	COG1846	Transcriptional regulator
GZK95_RS19930	COG1119	ATPase activity
GZK95_RS19935	COG0583	DNA-binding transcription factor activity
GZK95_RS19945	COG2207	Transcriptional regulator
GZK95_RS19945	COG3708	Transcriptional regulator
GZK95_RS19955	COG4592	Periplasmic binding protein
GZK95_RS19960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZK95_RS19965	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZK95_RS19970	COG1120	ATPase activity
GZK95_RS19975	COG1629	transport
GZK95_RS19975	COG4774	siderophore transport
GZK95_RS19985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZK95_RS20050	COG3313	Fe-S protein
GZK95_RS20075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GZK95_RS20085	COG1309	transcriptional regulator
GZK95_RS20095	COG3706	GGDEF domain
GZK95_RS20095	COG4251	negative regulation of phosphorylation
GZK95_RS20095	COG5001	Diguanylate cyclase
GZK95_RS20095	COG2203	Gaf domain
GZK95_RS20100	COG4989	oxidoreductase activity
GZK95_RS20105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GZK95_RS20115	COG0109	protoheme IX farnesyltransferase activity
GZK95_RS20120	COG1612	heme a metabolic process
GZK95_RS20150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZK95_RS20160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZK95_RS20170	COG1280	lysine exporter protein (LysE YggA)
GZK95_RS20190	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZK95_RS20210	COG4667	esterase of the alpha-beta hydrolase superfamily
GZK95_RS20230	COG0513	Belongs to the DEAD box helicase family
GZK95_RS20235	COG1940	carbohydrate kinase activity
GZK95_RS20240	COG2199	diguanylate cyclase activity
GZK95_RS20245	COG1914	H( )-stimulated, divalent metal cation uptake system
GZK95_RS20250	COG0814	amino acid
GZK95_RS20255	COG2384	SAM-dependent methyltransferase
GZK95_RS20260	COG2814	Major facilitator Superfamily
GZK95_RS20275	COG3530	Putative quorum-sensing-regulated virulence factor
GZK95_RS20290	COG1686	Belongs to the peptidase S11 family
GZK95_RS20300	COG1278	Cold shock
GZK95_RS20315	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GZK95_RS20420	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GZK95_RS20425	COG0513	Belongs to the DEAD box helicase family
GZK95_RS20440	COG1609	Transcriptional regulator
GZK95_RS20445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZK95_RS20450	COG1879	ABC-type sugar transport system periplasmic component
GZK95_RS20455	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZK95_RS20460	COG1129	ABC transporter
GZK95_RS20465	COG1869	D-ribose catabolic process
GZK95_RS20535	COG0583	DNA-binding transcription factor activity
GZK95_RS20550	COG3123	guanosine phosphorylase activity
GZK95_RS20555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZK95_RS20565	COG0668	transmembrane transport
GZK95_RS20570	COG2211	Major facilitator Superfamily
GZK95_RS20580	COG1309	transcriptional regulator
GZK95_RS20585	COG0346	lactoylglutathione lyase activity
GZK95_RS20590	COG4628	conserved protein (DUF2132)
GZK95_RS20595	COG0737	Belongs to the 5'-nucleotidase family
GZK95_RS20605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZK95_RS20615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZK95_RS20620	COG0840	transmembrane signaling receptor activity
GZK95_RS20625	COG0840	transmembrane signaling receptor activity
GZK95_RS20650	COG0583	DNA-binding transcription factor activity
GZK95_RS20655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GZK95_RS20670	COG0564	pseudouridine synthase activity
GZK95_RS20675	COG3706	GGDEF domain
GZK95_RS20680	COG0110	maltose O-acetyltransferase activity
GZK95_RS20685	COG0589	response to stress
GZK95_RS20700	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GZK95_RS20725	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZK95_RS20750	COG0745	RESPONSE REGULATOR receiver
GZK95_RS20760	COG1653	transport
GZK95_RS20810	COG0561	phosphatase activity
GZK95_RS20825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZK95_RS20830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZK95_RS20845	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GZK95_RS20850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZK95_RS20850	COG0574	Belongs to the PEP-utilizing enzyme family
GZK95_RS20880	COG0242	peptide deformylase activity
GZK95_RS20900	COG0786	glutamate:sodium symporter activity
GZK95_RS20905	COG4628	conserved protein (DUF2132)
GZK95_RS20910	COG0488	(ABC) transporter
GZK95_RS20925	COG1301	dicarboxylic acid transport
GZK95_RS20930	COG1252	NADH dehydrogenase
GZK95_RS20940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZK95_RS20955	COG4968	Prepilin-type N-terminal cleavage methylation domain
GZK95_RS20970	COG2814	Major facilitator Superfamily
GZK95_RS20985	COG1349	DNA-binding transcription factor activity
GZK95_RS20990	COG1882	Formate acetyltransferase
GZK95_RS20995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GZK95_RS21005	COG4774	siderophore transport
GZK95_RS21005	COG1629	transport
GZK95_RS21025	COG0583	DNA-binding transcription factor activity
GZK95_RS21035	COG2885	chlorophyll binding
GZK95_RS21055	COG0583	DNA-binding transcription factor activity
GZK95_RS21065	COG2860	membrane
GZK95_RS21070	COG0076	glutamate decarboxylase activity
GZK95_RS21075	COG2066	Belongs to the glutaminase family
GZK95_RS21080	COG0531	amino acid
GZK95_RS21100	COG4176	ABC-type proline glycine betaine transport system permease component
GZK95_RS21105	COG4175	Glycine betaine
GZK95_RS21105	COG3448	diguanylate cyclase activity
GZK95_RS21165	COG2226	methyltransferase
GZK95_RS21175	COG0840	transmembrane signaling receptor activity
GZK95_RS21180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZK95_RS21185	COG1482	cell wall glycoprotein biosynthetic process
GZK95_RS21190	COG0383	alpha-mannosidase activity
GZK95_RS21195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS21195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZK95_RS21195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZK95_RS21200	COG2188	Transcriptional regulator
GZK95_RS21215	COG2188	Transcriptional regulator
GZK95_RS21225	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GZK95_RS21240	COG3457	Alanine racemase
GZK95_RS21245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GZK95_RS21255	COG0346	lactoylglutathione lyase activity
GZK95_RS21265	COG2258	MOSC domain
GZK95_RS21275	COG1342	Belongs to the UPF0251 family
GZK95_RS21300	COG0840	transmembrane signaling receptor activity
GZK95_RS21315	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GZK95_RS21315	COG1918	ferrous iron import across plasma membrane
GZK95_RS21340	COG1131	(ABC) transporter
GZK95_RS21365	COG1595	DNA-templated transcription, initiation
GZK95_RS21415	COG0583	DNA-binding transcription factor activity
GZK95_RS21475	COG0739	heme binding
GZK95_RS21520	COG3501	Rhs element vgr protein
GZK95_RS21560	COG0583	DNA-binding transcription factor activity
GZK95_RS21565	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GZK95_RS21575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZK95_RS21580	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZK95_RS21605	COG2076	Multidrug Resistance protein
GZK95_RS21615	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GZK95_RS21625	COG2217	Heavy metal translocating P-type atpase
GZK95_RS21660	COG0583	DNA-binding transcription factor activity
GZK95_RS21685	COG0604	alcohol dehydrogenase
GZK95_RS21705	COG0183	Belongs to the thiolase family
GZK95_RS21710	COG1028	Short-chain dehydrogenase reductase Sdr
GZK95_RS21715	COG0583	DNA-binding transcription factor activity
GZK95_RS21720	COG4670	ketone body catabolic process
GZK95_RS21725	COG2030	dehydratase
GZK95_RS21730	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZK95_RS21755	COG1846	Transcriptional regulator
GZK95_RS21780	COG1444	tRNA N-acetyltransferase activity
GZK95_RS21910	COG1486	melibiose metabolic process
GZK95_RS21950	COG4974	Belongs to the 'phage' integrase family
GZK95_RS22015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily