locus-tag	class	description
RK51_RS00010	COG0070	glutamate synthase
RK51_RS00010	COG0067	glutamate synthase
RK51_RS00010	COG0069	glutamate synthase activity
RK51_RS00015	COG0493	'glutamate synthase
RK51_RS00025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RK51_RS00035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RK51_RS00040	COG2860	membrane
RK51_RS00045	COG0583	DNA-binding transcription factor activity
RK51_RS00050	COG0730	response to heat
RK51_RS00065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RK51_RS00070	COG0505	Belongs to the CarA family
RK51_RS00075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RK51_RS00080	COG0494	nUDIX hydrolase
RK51_RS00085	COG0653	protein targeting
RK51_RS00095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RK51_RS00100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RK51_RS00105	COG0849	cell division
RK51_RS00110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RK51_RS00115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RK51_RS00120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RK51_RS00125	COG0772	Belongs to the SEDS family
RK51_RS00130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RK51_RS00135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RK51_RS00140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RK51_RS00145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RK51_RS00150	COG0768	penicillin binding
RK51_RS00155	COG3116	cell division
RK51_RS00160	COG0275	rRNA processing
RK51_RS00175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RK51_RS00185	COG0792	nuclease activity
RK51_RS00190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RK51_RS00195	COG2823	Periplasmic or secreted lipoprotein
RK51_RS00200	COG2969	positive regulation of protein catabolic process
RK51_RS00205	COG0625	glutathione transferase activity
RK51_RS00210	COG2857	Cytochrome c1
RK51_RS00215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RK51_RS00220	COG0723	plastoquinol--plastocyanin reductase activity
RK51_RS00225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RK51_RS00230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RK51_RS00240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RK51_RS00250	COG3105	Protein conserved in bacteria
RK51_RS00260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RK51_RS00265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RK51_RS00275	COG3150	esterase
RK51_RS00285	COG3151	Protein conserved in bacteria
RK51_RS00290	COG0494	nUDIX hydrolase
RK51_RS00295	COG1538	Outer membrane efflux protein
RK51_RS00300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RK51_RS00300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RK51_RS00305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RK51_RS00320	COG3025	triphosphatase activity
RK51_RS00325	COG1392	Phosphate transport regulator
RK51_RS00330	COG0306	phosphate transporter
RK51_RS00335	COG4991	sh3 domain protein
RK51_RS00345	COG3409	Peptidoglycan-binding domain 1 protein
RK51_RS00345	COG3267	Type II secretory pathway component ExeA
RK51_RS00350	COG0617	tRNA 3'-terminal CCA addition
RK51_RS00355	COG1968	undecaprenyl-diphosphatase activity
RK51_RS00360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RK51_RS00365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RK51_RS00370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RK51_RS00375	COG0596	Alpha beta hydrolase
RK51_RS00380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RK51_RS00385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RK51_RS00390	COG1610	YqeY-like protein
RK51_RS00395	COG0358	DNA primase activity
RK51_RS00410	COG1464	Belongs to the NlpA lipoprotein family
RK51_RS00420	COG2207	Transcriptional regulator
RK51_RS00455	COG2213	PTS system mannitol-specific
RK51_RS00455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_RS00460	COG0246	Mannitol dehydrogenase
RK51_RS00465	COG3722	fumarate hydratase activity
RK51_RS00480	COG1461	Dihydroxyacetone kinase
RK51_RS00485	COG2376	Dihydroxyacetone kinase
RK51_RS00495	COG5002	protein histidine kinase activity
RK51_RS00510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RK51_RS00515	COG1349	DNA-binding transcription factor activity
RK51_RS00525	COG0469	pyruvate kinase activity
RK51_RS00540	COG0440	acetolactate synthase activity
RK51_RS00545	COG0028	Belongs to the TPP enzyme family
RK51_RS00550	COG1022	Amp-dependent synthetase and ligase
RK51_RS00555	COG0583	DNA-binding transcription factor activity
RK51_RS00575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RK51_RS00580	COG0473	3-isopropylmalate dehydrogenase activity
RK51_RS00585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RK51_RS00590	COG0066	3-isopropylmalate dehydratase activity
RK51_RS00600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RK51_RS00605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RK51_RS00610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK51_RS00615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RK51_RS00620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RK51_RS00625	COG2967	ApaG domain
RK51_RS00630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RK51_RS00645	COG2966	Psort location CytoplasmicMembrane, score
RK51_RS00650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RK51_RS00660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RK51_RS00665	COG0142	geranyltranstransferase activity
RK51_RS00675	COG0039	L-malate dehydrogenase activity
RK51_RS00690	COG2358	TRAP transporter, solute receptor (TAXI family
RK51_RS00710	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
RK51_RS00715	COG1178	ABC-type Fe3 transport system permease component
RK51_RS00720	COG4143	(ABC) transporter
RK51_RS00725	COG0163	prenyltransferase activity
RK51_RS00730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RK51_RS00740	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RK51_RS00745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RK51_RS00755	COG2105	PFAM AIG2 family protein
RK51_RS00760	COG2911	Protein conserved in bacteria
RK51_RS00765	COG0729	surface antigen
RK51_RS00770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK51_RS00780	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RK51_RS00795	COG4181	ATPase activity
RK51_RS00815	COG0529	Catalyzes the synthesis of activated sulfate
RK51_RS00820	COG3273	potassium ion transport
RK51_RS00820	COG0471	metal ion transport
RK51_RS00830	COG2895	sulfate adenylyltransferase (ATP) activity
RK51_RS00835	COG0175	sulfate reduction
RK51_RS00840	COG1648	precorrin-2 dehydrogenase activity
RK51_RS00840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RK51_RS00845	COG0737	Belongs to the 5'-nucleotidase family
RK51_RS00855	COG0513	Belongs to the DEAD box helicase family
RK51_RS00860	COG2153	protein acetylation
RK51_RS00870	COG0545	Peptidyl-prolyl cis-trans isomerase
RK51_RS00880	COG0203	ribosomal protein L17
RK51_RS00885	COG0202	RNA polymerase activity
RK51_RS00895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RK51_RS00900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RK51_RS00905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RK51_RS00910	COG0201	protein transport
RK51_RS00915	COG0200	Binds to the 23S rRNA
RK51_RS00920	COG1841	ribosomal large subunit assembly
RK51_RS00935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RK51_RS00940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RK51_RS00945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RK51_RS00950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RK51_RS00955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RK51_RS00960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RK51_RS00965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RK51_RS00970	COG0255	Belongs to the universal ribosomal protein uL29 family
RK51_RS00980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RK51_RS00985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RK51_RS00990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RK51_RS00995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RK51_RS01005	COG0088	Forms part of the polypeptide exit tunnel
RK51_RS01010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RK51_RS01020	COG0254	rRNA binding
RK51_RS01030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RK51_RS01035	COG1609	Transcriptional regulator
RK51_RS01045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RK51_RS01050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RK51_RS01055	COG1575	Belongs to the MenA family. Type 1 subfamily
RK51_RS01060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RK51_RS01065	COG3074	FtsZ-dependent cytokinesis
RK51_RS01075	COG1494	fructose-1,6-bisphosphatase
RK51_RS01100	COG0149	triose-phosphate isomerase activity
RK51_RS01105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RK51_RS01125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RK51_RS01140	COG1482	cell wall glycoprotein biosynthetic process
RK51_RS01160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RK51_RS01165	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RK51_RS01170	COG0438	transferase activity, transferring glycosyl groups
RK51_RS01260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK51_RS01270	COG1560	Kdo2-lipid A biosynthetic process
RK51_RS01290	COG1519	Transferase
RK51_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS01350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RK51_RS01360	COG3642	lipopolysaccharide core region biosynthetic process
RK51_RS01365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RK51_RS01370	COG0859	PFAM glycosyl transferase family 9
RK51_RS01375	COG0463	Glycosyl transferase, family 2
RK51_RS01390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RK51_RS01395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RK51_RS01405	COG2194	sulfuric ester hydrolase activity
RK51_RS01415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RK51_RS01420	COG2003	Belongs to the UPF0758 family
RK51_RS01435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RK51_RS01440	COG1309	transcriptional regulator
RK51_RS01445	COG1560	Kdo2-lipid A biosynthetic process
RK51_RS01450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RK51_RS01455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RK51_RS01460	COG1561	YicC-like family, N-terminal region
RK51_RS01480	COG2003	Belongs to the UPF0758 family
RK51_RS01545	COG0328	RNA-DNA hybrid ribonuclease activity
RK51_RS01590	COG4608	Belongs to the ABC transporter superfamily
RK51_RS01595	COG0444	Belongs to the ABC transporter superfamily
RK51_RS01600	COG0747	negative chemotaxis
RK51_RS01605	COG4239	(ABC) transporter, permease
RK51_RS01610	COG4174	ABC transporter (Permease)
RK51_RS01635	COG0811	peptide transport
RK51_RS01640	COG0848	biopolymer transport protein
RK51_RS01655	COG0194	GDP metabolic process
RK51_RS01660	COG1758	RNA polymerase activity
RK51_RS01665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RK51_RS01670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RK51_RS01675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RK51_RS01685	COG2233	PERMEase
RK51_RS01705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK51_RS01715	COG2183	response to ionizing radiation
RK51_RS01725	COG0596	Alpha beta hydrolase
RK51_RS01730	COG1040	competence protein
RK51_RS01735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RK51_RS01735	COG0316	Belongs to the HesB IscA family
RK51_RS01740	COG0494	nUDIX hydrolase
RK51_RS01745	COG1218	3'(2'),5'-bisphosphate nucleotidase
RK51_RS01755	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RK51_RS01760	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RK51_RS01765	COG3156	type II secretion system protein K
RK51_RS01770	COG4795	General secretion pathway protein
RK51_RS01775	COG2165	general secretion pathway protein
RK51_RS01780	COG2165	general secretion pathway protein
RK51_RS01785	COG2165	general secretion pathway protein
RK51_RS01790	COG1459	type II secretion system
RK51_RS01795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK51_RS01805	COG3031	protein transport across the cell outer membrane
RK51_RS01810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RK51_RS01815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RK51_RS01820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RK51_RS01830	COG0456	acetyltransferase
RK51_RS01835	COG1490	D-aminoacyl-tRNA deacylase activity
RK51_RS01840	COG1295	ribonuclease BN
RK51_RS01855	COG1217	gtp-binding protein TYPA
RK51_RS01860	COG0174	glutamine synthetase
RK51_RS01870	COG3852	Histidine kinase
RK51_RS01875	COG2204	response regulator
RK51_RS01885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RK51_RS01925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RK51_RS01935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK51_RS01935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK51_RS01960	COG0084	hydrolase, TatD family'
RK51_RS01970	COG0805	protein transport
RK51_RS01975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RK51_RS01980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RK51_RS01985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RK51_RS01990	COG3165	ubiquinone biosynthetic process from chorismate
RK51_RS01995	COG2226	methyltransferase
RK51_RS02000	COG1322	Protein conserved in bacteria
RK51_RS02015	COG0628	permease
RK51_RS02065	COG2823	Periplasmic or secreted lipoprotein
RK51_RS02075	COG2081	HI0933 family
RK51_RS02085	COG1528	Iron-storage protein
RK51_RS02090	COG0589	response to stress
RK51_RS02105	COG0742	ribosomal rna small subunit methyltransferase
RK51_RS02110	COG5001	Diguanylate cyclase
RK51_RS02110	COG5002	protein histidine kinase activity
RK51_RS02115	COG1522	sequence-specific DNA binding
RK51_RS02120	COG0339	signal peptide processing
RK51_RS02130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RK51_RS02135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK51_RS02140	COG0583	DNA-binding transcription factor activity
RK51_RS02145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RK51_RS02150	COG0800	Aldolase
RK51_RS02155	COG2610	gluconate transmembrane transporter activity
RK51_RS02160	COG3265	gluconokinase activity
RK51_RS02165	COG0129	dihydroxy-acid dehydratase activity
RK51_RS02180	COG0583	DNA-binding transcription factor activity
RK51_RS02185	COG1609	Transcriptional regulator
RK51_RS02225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_RS02230	COG0601	transmembrane transport
RK51_RS02235	COG0747	negative chemotaxis
RK51_RS02240	COG4172	Belongs to the ABC transporter superfamily
RK51_RS02305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_RS02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_RS02320	COG2960	long-chain fatty acid transporting porin activity
RK51_RS02325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RK51_RS02330	COG0583	DNA-binding transcription factor activity
RK51_RS02365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RK51_RS02375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RK51_RS02380	COG0408	coproporphyrinogen oxidase activity
RK51_RS02385	COG0009	L-threonylcarbamoyladenylate synthase
RK51_RS02390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RK51_RS02395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RK51_RS02400	COG0551	DNA topoisomerase type I activity
RK51_RS02405	COG2922	Belongs to the Smg family
RK51_RS02410	COG0758	DNA mediated transformation
RK51_RS02420	COG0242	peptide deformylase activity
RK51_RS02425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RK51_RS02430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RK51_RS02430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RK51_RS02435	COG0569	domain protein
RK51_RS02440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK51_RS02450	COG1272	protein, Hemolysin III
RK51_RS02455	COG4326	sporulation control protein
RK51_RS02465	COG3084	Protein conserved in bacteria
RK51_RS02475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RK51_RS02480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK51_RS02485	COG0204	Acyl-transferase
RK51_RS02495	COG0606	chelatase, subunit chli
RK51_RS02505	COG3978	acetolactate synthase activity
RK51_RS02510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RK51_RS02515	COG0129	dihydroxy-acid dehydratase activity
RK51_RS02525	COG0583	DNA-binding transcription factor activity
RK51_RS02530	COG2814	Major facilitator Superfamily
RK51_RS02535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_RS02540	COG0765	amino acid transport
RK51_RS02545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RK51_RS02550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RK51_RS02555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RK51_RS02560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RK51_RS02565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RK51_RS02570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RK51_RS02585	COG0356	it plays a direct role in the translocation of protons across the membrane
RK51_RS02590	COG3312	ion transport
RK51_RS02595	COG1475	DNA binding
RK51_RS02600	COG1192	Involved in chromosome partitioning
RK51_RS02605	COG0357	Ribosomal RNA small subunit methyltransferase G
RK51_RS02610	COG0445	tRNA wobble uridine modification
RK51_RS02615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RK51_RS02670	COG3645	SOS response
RK51_RS02675	COG3645	SOS response
RK51_RS02685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RK51_RS02725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RK51_RS02730	COG0706	membrane insertase activity
RK51_RS02740	COG0594	ribonuclease P activity
RK51_RS02750	COG1126	abc transporter atp-binding protein
RK51_RS02775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RK51_RS02780	COG0592	DNA-directed DNA polymerase activity
RK51_RS02785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RK51_RS02790	COG0187	DNA topoisomerase II activity
RK51_RS02810	COG0071	Belongs to the small heat shock protein (HSP20) family
RK51_RS02815	COG3977	Valine--pyruvate aminotransferase
RK51_RS02820	COG0366	Alpha amylase catalytic
RK51_RS02825	COG0751	glycine-tRNA ligase activity
RK51_RS02830	COG0752	glycyl-tRNA synthetase alpha subunit
RK51_RS02835	COG2119	membrane
RK51_RS02845	COG0425	Belongs to the sulfur carrier protein TusA family
RK51_RS02860	COG0604	alcohol dehydrogenase
RK51_RS02865	COG0183	Belongs to the thiolase family
RK51_RS02870	COG1024	Enoyl-CoA hydratase
RK51_RS02870	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK51_RS02875	COG1739	Uncharacterized protein family UPF0029
RK51_RS02880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK51_RS02935	COG3335	DDE superfamily endonuclease
RK51_RS02940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RK51_RS02945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RK51_RS02950	COG0352	thiamine-phosphate diphosphorylase activity
RK51_RS02955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RK51_RS02960	COG2104	thiamine diphosphate biosynthetic process
RK51_RS02965	COG2022	thiamine diphosphate biosynthetic process
RK51_RS02975	COG0006	proline dipeptidase activity
RK51_RS02975	COG0006	proline dipeptidase activity
RK51_RS03005	COG3220	belongs to the UPF0276 family
RK51_RS03015	COG0210	DNA helicase
RK51_RS03025	COG0405	Gamma-glutamyltransferase
RK51_RS03030	COG1280	lysine exporter protein (LysE YggA)
RK51_RS03040	COG2962	Rard protein
RK51_RS03045	COG0514	ATP-dependent DNA helicase (RecQ)
RK51_RS03060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RK51_RS03065	COG0248	Ppx GppA phosphatase
RK51_RS03070	COG0513	Belongs to the DEAD box helicase family
RK51_RS03075	COG3118	belongs to the thioredoxin family
RK51_RS03095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RK51_RS03100	COG0633	Ferredoxin
RK51_RS03150	COG3071	HemY protein
RK51_RS03155	COG2959	enzyme of heme biosynthesis
RK51_RS03160	COG1587	Uroporphyrinogen-III synthase
RK51_RS03165	COG0181	hydroxymethylbilane synthase activity
RK51_RS03170	COG3072	Adenylate cyclase
RK51_RS03175	COG1965	Belongs to the frataxin family
RK51_RS03185	COG0019	diaminopimelate decarboxylase activity
RK51_RS03190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RK51_RS03200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RK51_RS03205	COG1011	Hydrolase
RK51_RS03210	COG3287	FIST C domain
RK51_RS03210	COG2200	EAL domain
RK51_RS03210	COG2199	diguanylate cyclase activity
RK51_RS03215	COG3148	PFAM DTW domain containing protein
RK51_RS03230	COG0561	phosphatase activity
RK51_RS03240	COG2267	carboxylic ester hydrolase activity
RK51_RS03245	COG1280	lysine exporter protein (LysE YggA)
RK51_RS03250	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RK51_RS03255	COG0640	Transcriptional regulator
RK51_RS03260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RK51_RS03315	COG2095	MarC family integral membrane protein
RK51_RS03325	COG0742	ribosomal rna small subunit methyltransferase
RK51_RS03330	COG0552	protein localization to endoplasmic reticulum
RK51_RS03335	COG2884	Cell division ATP-binding protein ftsE
RK51_RS03340	COG2177	Part of the ABC transporter FtsEX involved in
RK51_RS03355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK51_RS03360	COG0705	Rhomboid family
RK51_RS03365	COG1580	Controls the rotational direction of flagella during chemotaxis
RK51_RS03370	COG3161	chorismate lyase activity
RK51_RS03375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RK51_RS03380	COG2937	Belongs to the GPAT DAPAT family
RK51_RS03390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RK51_RS03395	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RK51_RS03400	COG0534	Mate efflux family protein
RK51_RS03405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK51_RS03420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RK51_RS03425	COG4206	TonB-dependent receptor
RK51_RS03435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RK51_RS03465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK51_RS03475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RK51_RS03515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RK51_RS03525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RK51_RS03530	COG0250	Participates in transcription elongation, termination and antitermination
RK51_RS03535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RK51_RS03540	COG0081	regulation of translation
RK51_RS03545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RK51_RS03550	COG0222	ribosome binding
RK51_RS03555	COG0085	RNA polymerase activity
RK51_RS03560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RK51_RS03565	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
RK51_RS03570	COG2816	NAD+ diphosphatase activity
RK51_RS03585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RK51_RS03590	COG1573	uracil-dna glycosylase
RK51_RS03595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK51_RS03605	COG1253	flavin adenine dinucleotide binding
RK51_RS03620	COG0151	Belongs to the GarS family
RK51_RS03630	COG0138	bifunctional purine biosynthesis protein purh
RK51_RS03640	COG0789	Transcriptional regulator
RK51_RS03645	COG3710	Transcriptional regulator
RK51_RS03655	COG0531	amino acid
RK51_RS03660	COG1982	Orn Lys Arg decarboxylase major
RK51_RS03715	COG3706	GGDEF domain
RK51_RS03720	COG0488	(ABC) transporter
RK51_RS03725	COG2814	Major facilitator Superfamily
RK51_RS03730	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RK51_RS03735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK51_RS03740	COG2264	protein methyltransferase activity
RK51_RS03750	COG0439	Biotin carboxylase
RK51_RS03755	COG0511	ligase activity, forming carbon-carbon bonds
RK51_RS03760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RK51_RS03765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK51_RS03780	COG2814	Major facilitator Superfamily
RK51_RS03785	COG2205	protein histidine kinase activity
RK51_RS03785	COG0784	Response regulator, receiver
RK51_RS03810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK51_RS03820	COG3263	regulation of cellular component size
RK51_RS03830	COG4232	protein-disulfide reductase activity
RK51_RS03835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RK51_RS03840	COG1027	Aspartate ammonia-lyase
RK51_RS03845	COG3030	protein affecting phage T7 exclusion by the F plasmid
RK51_RS03850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RK51_RS03860	COG2205	protein histidine kinase activity
RK51_RS03865	COG0745	RESPONSE REGULATOR receiver
RK51_RS03875	COG3678	ATP-independent chaperone mediated protein folding
RK51_RS03885	COG0205	6-phosphofructokinase activity
RK51_RS03890	COG0534	Mate efflux family protein
RK51_RS03900	COG0459	protein refolding
RK51_RS03920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RK51_RS03935	COG1509	lysine 2,3-aminomutase activity
RK51_RS03940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RK51_RS03950	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
RK51_RS03955	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
RK51_RS03960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RK51_RS03965	COG1053	succinate dehydrogenase
RK51_RS03975	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
RK51_RS03995	COG4942	peptidase
RK51_RS04000	COG1045	serine acetyltransferase
RK51_RS04005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RK51_RS04010	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RK51_RS04015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK51_RS04020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RK51_RS04035	COG0471	metal ion transport
RK51_RS04040	COG0688	phosphatidylethanolamine metabolic process
RK51_RS04045	COG1162	GTPase activity
RK51_RS04050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RK51_RS04120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RK51_RS04125	COG0802	atpase or kinase
RK51_RS04130	COG0860	N-Acetylmuramoyl-L-alanine amidase
RK51_RS04135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RK51_RS04140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RK51_RS04150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RK51_RS04155	COG0330	HflC and HflK could
RK51_RS04160	COG0330	HflC and HflK could
RK51_RS04165	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
RK51_RS04170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RK51_RS04180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RK51_RS04185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK51_RS04185	COG1017	nitric oxide dioxygenase activity
RK51_RS04190	COG1959	2 iron, 2 sulfur cluster binding
RK51_RS04195	COG0557	exoribonuclease II activity
RK51_RS04200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RK51_RS04205	COG0546	phosphoglycolate phosphatase activity
RK51_RS04210	COG0180	Tryptophanyl-tRNA synthetase
RK51_RS04240	COG0512	Glutamine amidotransferase of anthranilate synthase
RK51_RS04245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RK51_RS04255	COG1012	belongs to the aldehyde dehydrogenase family
RK51_RS04265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK51_RS04270	COG3954	Phosphoribulokinase
RK51_RS04275	COG3089	Belongs to the UPF0270 family
RK51_RS04280	COG0429	hydrolase of the alpha beta-hydrolase fold
RK51_RS04290	COG0488	(ABC) transporter
RK51_RS04300	COG2249	NAD(P)H dehydrogenase (quinone) activity
RK51_RS04315	COG1047	Peptidyl-prolyl cis-trans
RK51_RS04325	COG1446	asparaginase
RK51_RS04330	COG2900	Belongs to the SlyX family
RK51_RS04340	COG0545	Peptidyl-prolyl cis-trans isomerase
RK51_RS04345	COG2964	Protein conserved in bacteria
RK51_RS04350	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RK51_RS04355	COG2923	Belongs to the DsrF TusC family
RK51_RS04360	COG2168	tRNA wobble position uridine thiolation
RK51_RS04370	COG0049	tRNA binding
RK51_RS04375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RK51_RS04380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RK51_RS04385	COG2906	2 iron, 2 sulfur cluster binding
RK51_RS04395	COG0281	malic enzyme
RK51_RS04405	COG0626	cystathionine gamma-synthase activity
RK51_RS04410	COG0460	homoserine dehydrogenase
RK51_RS04410	COG0527	aspartate kinase activity
RK51_RS04415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RK51_RS04420	COG1695	Transcriptional regulator
RK51_RS04425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RK51_RS04430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RK51_RS04435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RK51_RS04440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RK51_RS04445	COG0137	argininosuccinate synthase activity
RK51_RS04450	COG0165	Argininosuccinate lyase
RK51_RS04450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RK51_RS04465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RK51_RS04465	COG0678	peroxiredoxin activity
RK51_RS04475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RK51_RS04505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RK51_RS04510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RK51_RS04520	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RK51_RS04525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RK51_RS04530	COG0360	Binds together with S18 to 16S ribosomal RNA
RK51_RS04535	COG2965	DNA replication, synthesis of RNA primer
RK51_RS04545	COG0359	binds to the 23S rRNA
RK51_RS04560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RK51_RS04570	COG0432	Pfam Uncharacterised protein family UPF0047
RK51_RS04575	COG0166	Belongs to the GPI family
RK51_RS04585	COG0735	belongs to the Fur family
RK51_RS04595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK51_RS04620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RK51_RS04625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK51_RS04630	COG0175	sulfate reduction
RK51_RS04710	COG0646	methionine synthase
RK51_RS04710	COG1410	methionine synthase
RK51_RS04715	COG0527	aspartate kinase activity
RK51_RS04725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RK51_RS04735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RK51_RS04750	COG0629	single-stranded DNA binding
RK51_RS04755	COG2200	EAL domain
RK51_RS04755	COG2199	diguanylate cyclase activity
RK51_RS04780	COG3267	Type II secretory pathway component ExeA
RK51_RS04780	COG3409	Peptidoglycan-binding domain 1 protein
RK51_RS04790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK51_RS04795	COG1459	type II secretion system
RK51_RS04805	COG2165	general secretion pathway protein
RK51_RS04840	COG1077	Cell shape determining protein MreB Mrl
RK51_RS04845	COG1792	Involved in formation and maintenance of cell shape
RK51_RS04850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RK51_RS04855	COG0424	maF-like protein
RK51_RS04865	COG3164	Protein of unknown function
RK51_RS04870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK51_RS04875	COG0312	modulator of DNA gyrase
RK51_RS04880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RK51_RS04885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RK51_RS04900	COG0564	pseudouridine synthase activity
RK51_RS04905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RK51_RS04910	COG3028	Belongs to the UPF0307 family
RK51_RS04915	COG0312	modulator of DNA gyrase
RK51_RS04920	COG2239	Acts as a magnesium transporter
RK51_RS04925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_RS04930	COG1660	Displays ATPase and GTPase activities
RK51_RS04935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_RS04940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RK51_RS04950	COG1137	ATPase activity
RK51_RS04955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RK51_RS04965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RK51_RS04965	COG0517	IMP dehydrogenase activity
RK51_RS04975	COG1127	ABC transporter
RK51_RS04980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RK51_RS04985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RK51_RS04990	COG2854	intermembrane phospholipid transfer
RK51_RS05000	COG5007	Belongs to the BolA IbaG family
RK51_RS05005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RK51_RS05010	COG0204	Acyl-transferase
RK51_RS05015	COG0251	oxidation-reduction process
RK51_RS05020	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
RK51_RS05025	COG0540	Belongs to the ATCase OTCase family
RK51_RS05035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RK51_RS05040	COG2235	arginine
RK51_RS05070	COG0525	valine-tRNA ligase activity
RK51_RS05075	COG2927	DNA polymerase III (CHI subunit)
RK51_RS05080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RK51_RS05085	COG0795	lipopolysaccharide-transporting ATPase activity
RK51_RS05090	COG0795	lipopolysaccharide-transporting ATPase activity
RK51_RS05115	COG0726	polysaccharide deacetylase
RK51_RS05120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RK51_RS05125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RK51_RS05130	COG1447	Phosphotransferase system cellobiose-specific component IIA
RK51_RS05135	COG1486	melibiose metabolic process
RK51_RS05140	COG3394	polysaccharide catabolic process
RK51_RS05150	COG3437	response regulator, receiver
RK51_RS05200	COG1012	belongs to the aldehyde dehydrogenase family
RK51_RS05270	COG0741	lytic transglycosylase activity
RK51_RS05275	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RK51_RS05285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RK51_RS05295	COG2066	Belongs to the glutaminase family
RK51_RS05300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RK51_RS05305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RK51_RS05315	COG1872	DUF167
RK51_RS05320	COG0762	integral membrane protein
RK51_RS05325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RK51_RS05330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RK51_RS05345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RK51_RS05350	COG1678	Uncharacterized ACR, COG1678
RK51_RS05355	COG0189	ligase activity
RK51_RS05360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RK51_RS05365	COG2356	endonuclease I
RK51_RS05370	COG3091	SprT-like family
RK51_RS05380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RK51_RS05390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RK51_RS05395	COG0583	DNA-binding transcription factor activity
RK51_RS05400	COG4771	TonB-dependent receptor
RK51_RS05405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RK51_RS05410	COG0126	phosphoglycerate kinase activity
RK51_RS05415	COG0191	fructose-bisphosphate aldolase activity
RK51_RS05420	COG0668	transmembrane transport
RK51_RS05425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RK51_RS05435	COG0583	DNA-binding transcription factor activity
RK51_RS05445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK51_RS05450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RK51_RS05455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RK51_RS05465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
RK51_RS05475	COG3079	Belongs to the UPF0149 family
RK51_RS05480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RK51_RS05485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RK51_RS05500	COG0354	folic acid binding
RK51_RS05505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RK51_RS05515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RK51_RS05525	COG1595	DNA-templated transcription, initiation
RK51_RS05530	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
RK51_RS05540	COG3086	response to oxidative stress
RK51_RS05545	COG0481	GTPase activity
RK51_RS05555	COG0571	ribonuclease III activity
RK51_RS05560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RK51_RS05565	COG1381	Involved in DNA repair and RecF pathway recombination
RK51_RS05570	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RK51_RS05575	COG0736	holo-[acyl-carrier-protein] synthase activity
RK51_RS05590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RK51_RS05600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RK51_RS05605	COG3956	TIGRFAM MazG family protein
RK51_RS05610	COG0504	CTP synthase activity
RK51_RS05615	COG0148	phosphopyruvate hydratase activity
RK51_RS05620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RK51_RS05625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RK51_RS05630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RK51_RS05635	COG0585	pseudouridine synthase activity
RK51_RS05640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RK51_RS05645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RK51_RS05660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RK51_RS05665	COG1546	Belongs to the CinA family
RK51_RS05670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RK51_RS05675	COG2137	regulation of response to DNA damage stimulus
RK51_RS05680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RK51_RS05685	COG0527	aspartate kinase activity
RK51_RS05745	COG3630	sodium ion export across plasma membrane
RK51_RS05750	COG0511	ligase activity, forming carbon-carbon bonds
RK51_RS05750	COG5016	pyruvate
RK51_RS05755	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
RK51_RS05765	COG1238	metal cluster binding
RK51_RS05770	COG0612	Peptidase, M16
RK51_RS05775	COG2918	glutathione biosynthetic process
RK51_RS05785	COG1854	S-ribosylhomocysteine lyase activity
RK51_RS05790	COG4536	flavin adenine dinucleotide binding
RK51_RS05795	COG4137	Cytochrome C assembly protein
RK51_RS05800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RK51_RS05805	COG0228	four-way junction DNA binding
RK51_RS05810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RK51_RS05815	COG0336	Belongs to the RNA methyltransferase TrmD family
RK51_RS05820	COG0335	large ribosomal subunit rRNA binding
RK51_RS05825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RK51_RS05830	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RK51_RS05835	COG0237	dephospho-CoA kinase activity
RK51_RS05845	COG1459	type II secretion system
RK51_RS05850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK51_RS05855	COG4969	Belongs to the N-Me-Phe pilin family
RK51_RS05860	COG0157	Belongs to the NadC ModD family
RK51_RS05870	COG2186	Transcriptional regulator
RK51_RS05875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RK51_RS05880	COG0508	dehydrogenase complex catalyzes the overall conversion of
RK51_RS05885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK51_RS05900	COG0288	reversible hydration of carbon dioxide
RK51_RS05905	COG0659	secondary active sulfate transmembrane transporter activity
RK51_RS05915	COG1131	(ABC) transporter
RK51_RS05920	COG0842	Transport permease protein
RK51_RS05930	COG1560	Kdo2-lipid A biosynthetic process
RK51_RS05940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RK51_RS05945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RK51_RS05950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RK51_RS05965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK51_RS05980	COG1489	DNA binding
RK51_RS05985	COG1643	Atp-dependent helicase
RK51_RS05990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RK51_RS05995	COG1752	Esterase of the alpha-beta hydrolase superfamily
RK51_RS06000	COG1049	propionate catabolic process, 2-methylcitrate cycle
RK51_RS06005	COG3112	Uncharacterised protein family (UPF0231)
RK51_RS06015	COG0004	ammonium transporteR
RK51_RS06020	COG1840	ABC-type Fe3 transport system, periplasmic component
RK51_RS06030	COG3842	ATPase activity
RK51_RS06035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RK51_RS06050	COG2971	BadF BadG BcrA BcrD
RK51_RS06060	COG4608	Belongs to the ABC transporter superfamily
RK51_RS06065	COG0444	Belongs to the ABC transporter superfamily
RK51_RS06070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_RS06080	COG0747	negative chemotaxis
RK51_RS06085	COG0784	Response regulator, receiver
RK51_RS06085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_RS06085	COG2198	Histidine kinase
RK51_RS06085	COG2205	protein histidine kinase activity
RK51_RS06095	COG2813	Specifically methylates the guanine in position
RK51_RS06100	COG0628	permease
RK51_RS06105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RK51_RS06110	COG0316	Belongs to the HesB IscA family
RK51_RS06120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_RS06125	COG0739	heme binding
RK51_RS06130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RK51_RS06140	COG2027	D-alanyl-D-alanine carboxypeptidase
RK51_RS06145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RK51_RS06150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK51_RS06155	COG1534	Rna-binding protein
RK51_RS06160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RK51_RS06165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RK51_RS06170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RK51_RS06175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RK51_RS06185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RK51_RS06200	COG0779	Required for maturation of 30S ribosomal subunits
RK51_RS06205	COG0195	Participates in both transcription termination and antitermination
RK51_RS06210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RK51_RS06215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RK51_RS06220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RK51_RS06225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RK51_RS06230	COG1185	polyribonucleotide nucleotidyltransferase activity
RK51_RS06245	COG0534	Mate efflux family protein
RK51_RS06250	COG0826	peptidase U32
RK51_RS06255	COG0826	peptidase U32
RK51_RS06265	COG3154	lipid carrier protein
RK51_RS06270	COG3153	acetyltransferase
RK51_RS06290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RK51_RS06300	COG0084	hydrolase, TatD family'
RK51_RS06305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK51_RS06310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RK51_RS06315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RK51_RS06320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RK51_RS06325	COG0813	purine-nucleoside phosphorylase activity
RK51_RS06335	COG0560	Phosphoserine phosphatase
RK51_RS06345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RK51_RS06350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RK51_RS06355	COG0583	DNA-binding transcription factor activity
RK51_RS06365	COG1022	Amp-dependent synthetase and ligase
RK51_RS06370	COG2169	Transcriptional regulator
RK51_RS06395	COG4964	Belongs to the GSP D family
RK51_RS06455	COG0583	DNA-binding transcription factor activity
RK51_RS06460	COG0531	amino acid
RK51_RS06465	COG2731	YhcH YjgK YiaL family protein
RK51_RS06470	COG3250	beta-galactosidase activity
RK51_RS06475	COG1609	Transcriptional regulator
RK51_RS06485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RK51_RS06495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RK51_RS06500	COG2017	converts alpha-aldose to the beta-anomer
RK51_RS06515	COG2211	Major facilitator Superfamily
RK51_RS06520	COG1609	Transcriptional regulator
RK51_RS06525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK51_RS06540	COG0598	Magnesium transport protein CorA
RK51_RS06545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RK51_RS06550	COG1349	DNA-binding transcription factor activity
RK51_RS06555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RK51_RS06560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RK51_RS06575	COG2271	Major facilitator Superfamily
RK51_RS06580	COG0584	glycerophosphoryl diester phosphodiesterase
RK51_RS06585	COG2171	N-acyltransferase activity
RK51_RS06590	COG3141	response to X-ray
RK51_RS06610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RK51_RS06620	COG1074	ATP-dependent DNA helicase activity
RK51_RS06625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RK51_RS06650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RK51_RS06650	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RK51_RS06665	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RK51_RS06670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RK51_RS06675	COG2166	iron-sulfur cluster assembly
RK51_RS06680	COG3706	GGDEF domain
RK51_RS06685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RK51_RS06690	COG0693	protein deglycase activity
RK51_RS06695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RK51_RS06720	COG1595	DNA-templated transcription, initiation
RK51_RS06740	COG3056	Lipoprotein
RK51_RS06745	COG2813	Specifically methylates the guanine in position
RK51_RS06750	COG0271	Belongs to the BolA IbaG family
RK51_RS06760	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RK51_RS06765	COG1805	sodium ion transport
RK51_RS06770	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RK51_RS06775	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RK51_RS06780	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RK51_RS06785	COG2871	sodium ion transport
RK51_RS06790	COG1477	protein flavinylation
RK51_RS06805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RK51_RS06810	COG0514	ATP-dependent DNA helicase (RecQ)
RK51_RS06815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK51_RS06830	COG0733	neurotransmitter:sodium symporter activity
RK51_RS06850	COG0442	prolyl-tRNA aminoacylation
RK51_RS06855	COG1720	tRNA m6t6A37 methyltransferase activity
RK51_RS06860	COG0254	rRNA binding
RK51_RS06875	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RK51_RS06880	COG1671	Belongs to the UPF0178 family
RK51_RS06905	COG3098	single-species biofilm formation
RK51_RS06910	COG0564	pseudouridine synthase activity
RK51_RS06920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RK51_RS06925	COG0024	Methionine aminopeptidase
RK51_RS06930	COG0052	Belongs to the universal ribosomal protein uS2 family
RK51_RS06935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RK51_RS06940	COG0528	UMP kinase activity
RK51_RS06945	COG0233	cytoplasmic translational termination
RK51_RS06950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RK51_RS06955	COG0575	Belongs to the CDS family
RK51_RS06960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RK51_RS06965	COG0750	zinc metalloprotease
RK51_RS06975	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RK51_RS06980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK51_RS06985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK51_RS06990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK51_RS06995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK51_RS07000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RK51_RS07005	COG0587	DNA-directed DNA polymerase activity
RK51_RS07010	COG0825	malonyl-CoA metabolic process
RK51_RS07015	COG0037	tRNA processing
RK51_RS07025	COG0347	Belongs to the P(II) protein family
RK51_RS07030	COG3021	interspecies interaction between organisms
RK51_RS07040	COG0741	lytic transglycosylase activity
RK51_RS07040	COG1388	LysM domain
RK51_RS07045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK51_RS07050	COG2226	methyltransferase
RK51_RS07055	COG0328	RNA-DNA hybrid ribonuclease activity
RK51_RS07060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RK51_RS07075	COG1960	acyl-CoA dehydrogenase activity
RK51_RS07080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RK51_RS07085	COG0121	glutamine amidotransferase
RK51_RS07090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RK51_RS07095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RK51_RS07100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RK51_RS07105	COG2233	PERMEase
RK51_RS07125	COG1393	Belongs to the ArsC family
RK51_RS07130	COG4783	chaperone-mediated protein folding
RK51_RS07145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RK51_RS07150	COG2716	regulation of RNA biosynthetic process
RK51_RS07155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK51_RS07160	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RK51_RS07175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RK51_RS07180	COG1393	Belongs to the ArsC family
RK51_RS07210	COG2837	iron assimilation
RK51_RS07215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS07225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS07230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS07235	COG1334	flagellar protein FlaG
RK51_RS07240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RK51_RS07250	COG1516	flagellar protein fliS
RK51_RS07270	COG1677	Flagellar hook-basal body complex protein FliE
RK51_RS07280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RK51_RS07330	COG1987	bacterial-type flagellum assembly
RK51_RS07335	COG1684	flagellar biosynthetic protein fliR
RK51_RS07370	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RK51_RS07375	COG0784	Response regulator, receiver
RK51_RS07375	COG0643	Histidine kinase
RK51_RS07375	COG2198	Histidine kinase
RK51_RS07380	COG2201	protein-glutamate methylesterase activity
RK51_RS07385	COG1192	Involved in chromosome partitioning
RK51_RS07395	COG0835	chemotaxis
RK51_RS07405	COG4133	protoheme IX ABC transporter activity
RK51_RS07410	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RK51_RS07415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RK51_RS07420	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RK51_RS07425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RK51_RS07430	COG1138	Cytochrome C-type biogenesis protein
RK51_RS07435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RK51_RS07450	COG2853	Lipoprotein
RK51_RS07455	COG2067	long-chain fatty acid transport protein
RK51_RS07460	COG2067	long-chain fatty acid transport protein
RK51_RS07480	COG0183	Belongs to the thiolase family
RK51_RS07485	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK51_RS07485	COG1024	Enoyl-CoA hydratase
RK51_RS07500	COG2062	phosphohistidine phosphatase, SixA
RK51_RS07505	COG2840	Smr protein MutS2
RK51_RS07510	COG2890	protein-(glutamine-N5) methyltransferase activity
RK51_RS07515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RK51_RS07520	COG2860	membrane
RK51_RS07530	COG3101	peptidyl-lysine hydroxylation
RK51_RS07545	COG0431	NADPH-dependent FMN reductase
RK51_RS07550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RK51_RS07550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK51_RS07555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK51_RS07565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK51_RS07570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RK51_RS07580	COG0101	tRNA pseudouridine synthase activity
RK51_RS07585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RK51_RS07590	COG0285	dihydrofolate synthase activity
RK51_RS07595	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
RK51_RS07600	COG1286	toxin biosynthetic process
RK51_RS07605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RK51_RS07610	COG0583	DNA-binding transcription factor activity
RK51_RS07615	COG0745	RESPONSE REGULATOR receiver
RK51_RS07625	COG2832	Protein of unknown function (DUF454)
RK51_RS07630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RK51_RS07640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RK51_RS07645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RK51_RS07650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RK51_RS07655	COG0814	amino acid
RK51_RS07660	COG0251	oxidation-reduction process
RK51_RS07665	COG3681	Belongs to the UPF0597 family
RK51_RS07680	COG2261	transglycosylase associated protein
RK51_RS07685	COG2983	Belongs to the UPF0260 family
RK51_RS07690	COG0668	transmembrane transport
RK51_RS07695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RK51_RS07700	COG0346	lactoylglutathione lyase activity
RK51_RS07710	COG1785	Belongs to the alkaline phosphatase family
RK51_RS07730	COG2226	methyltransferase
RK51_RS07745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RK51_RS07750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK51_RS07760	COG3139	Protein of unknown function (DUF1315)
RK51_RS07765	COG0252	asparaginase activity
RK51_RS07770	COG0616	signal peptide processing
RK51_RS07775	COG1902	pentaerythritol trinitrate reductase activity
RK51_RS07775	COG0446	pyridine nucleotide-disulphide oxidoreductase
RK51_RS07780	COG0778	Nitroreductase
RK51_RS07785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RK51_RS07805	COG0123	including yeast histone deacetylase and acetoin utilization protein
RK51_RS07815	COG3083	sulfuric ester hydrolase activity
RK51_RS07820	COG3082	Protein of unknown function (DUF1414)
RK51_RS07825	COG3081	Nucleoid-associated protein
RK51_RS07840	COG1757	Na H antiporter
RK51_RS07845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RK51_RS07850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK51_RS07855	COG2095	MarC family integral membrane protein
RK51_RS07860	COG1454	alcohol dehydrogenase
RK51_RS07860	COG1012	belongs to the aldehyde dehydrogenase family
RK51_RS07880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RK51_RS07890	COG2056	Na+-H+ antiporter family
RK51_RS07895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RK51_RS07910	COG2885	chlorophyll binding
RK51_RS07920	COG0346	lactoylglutathione lyase activity
RK51_RS07925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RK51_RS07930	COG4660	Part of a membrane complex involved in electron transport
RK51_RS07935	COG4659	FMN binding
RK51_RS07940	COG4658	electron transport chain
RK51_RS07945	COG4656	Part of a membrane complex involved in electron transport
RK51_RS07950	COG2878	Part of a membrane complex involved in electron transport
RK51_RS07955	COG4657	Part of a membrane complex involved in electron transport
RK51_RS07970	COG0556	nucleotide-excision repair
RK51_RS07975	COG2204	response regulator
RK51_RS07980	COG2198	Histidine kinase
RK51_RS07985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RK51_RS07990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RK51_RS07995	COG0521	Mo-molybdopterin cofactor biosynthetic process
RK51_RS08000	COG0315	cyclic pyranopterin monophosphate synthase activity
RK51_RS08005	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RK51_RS08010	COG0314	molybdopterin synthase activity
RK51_RS08020	COG0601	transmembrane transport
RK51_RS08025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_RS08030	COG0444	Belongs to the ABC transporter superfamily
RK51_RS08040	COG0435	Glutathione S-transferase
RK51_RS08050	COG3174	membrane
RK51_RS08055	COG0280	phosphate acetyltransferase
RK51_RS08055	COG0857	belongs to the CobB CobQ family
RK51_RS08060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RK51_RS08065	COG3092	negative regulation of chromosome organization
RK51_RS08075	COG4120	Belongs to the binding-protein-dependent transport system permease family
RK51_RS08080	COG1122	ATPase activity
RK51_RS08085	COG0366	Alpha amylase catalytic
RK51_RS08095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK51_RS08100	COG0653	protein targeting
RK51_RS08105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RK51_RS08110	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK51_RS08115	COG2186	Transcriptional regulator
RK51_RS08125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK51_RS08125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK51_RS08130	COG0489	protein tyrosine kinase activity
RK51_RS08135	COG0572	uridine kinase
RK51_RS08145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RK51_RS08150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RK51_RS08155	COG0659	secondary active sulfate transmembrane transporter activity
RK51_RS08165	COG1530	ribonuclease E activity
RK51_RS08180	COG0564	pseudouridine synthase activity
RK51_RS08185	COG0424	maF-like protein
RK51_RS08190	COG1399	metal-binding, possibly nucleic acid-binding protein
RK51_RS08200	COG0416	fatty acid biosynthetic process
RK51_RS08205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RK51_RS08235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RK51_RS08240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RK51_RS08250	COG0084	hydrolase, TatD family'
RK51_RS08255	COG1263	PTS System
RK51_RS08255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_RS08275	COG0733	neurotransmitter:sodium symporter activity
RK51_RS08290	COG4667	esterase of the alpha-beta hydrolase superfamily
RK51_RS08295	COG0469	pyruvate kinase activity
RK51_RS08300	COG1940	carbohydrate kinase activity
RK51_RS08305	COG0835	chemotaxis
RK51_RS08305	COG0784	Response regulator, receiver
RK51_RS08310	COG0587	DNA-directed DNA polymerase activity
RK51_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS08330	COG0616	signal peptide processing
RK51_RS08335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RK51_RS08340	COG0539	negative regulation of cytoplasmic translation
RK51_RS08350	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
RK51_RS08355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RK51_RS08360	COG0284	orotidine-5'-phosphate decarboxylase activity
RK51_RS08365	COG4166	transmembrane transport
RK51_RS08380	COG0463	Glycosyl transferase, family 2
RK51_RS08390	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RK51_RS08400	COG3008	intermembrane lipid transfer
RK51_RS08400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RK51_RS08405	COG2995	paraquat-inducible protein a
RK51_RS08410	COG3258	Cytochrome c
RK51_RS08415	COG2863	cytochrome
RK51_RS08455	COG4232	protein-disulfide reductase activity
RK51_RS08460	COG3118	belongs to the thioredoxin family
RK51_RS08490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_RS08500	COG0577	efflux transmembrane transporter activity
RK51_RS08500	COG1136	(ABC) transporter
RK51_RS08505	COG0577	efflux transmembrane transporter activity
RK51_RS08505	COG1136	(ABC) transporter
RK51_RS08510	COG0577	efflux transmembrane transporter activity
RK51_RS08510	COG1136	(ABC) transporter
RK51_RS08515	COG1335	isochorismatase
RK51_RS08530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RK51_RS08565	COG5002	protein histidine kinase activity
RK51_RS08565	COG3850	Histidine kinase
RK51_RS08570	COG0745	RESPONSE REGULATOR receiver
RK51_RS08580	COG0840	transmembrane signaling receptor activity
RK51_RS08585	COG1032	radical SAM domain protein
RK51_RS08590	COG4251	negative regulation of phosphorylation
RK51_RS08590	COG5001	Diguanylate cyclase
RK51_RS08590	COG3706	GGDEF domain
RK51_RS08590	COG2203	Gaf domain
RK51_RS08605	COG0583	DNA-binding transcription factor activity
RK51_RS08615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RK51_RS08625	COG2350	Protein conserved in bacteria
RK51_RS08635	COG2917	probably involved in intracellular septation
RK51_RS08655	COG1301	dicarboxylic acid transport
RK51_RS08665	COG0318	PFAM AMP-dependent synthetase and ligase
RK51_RS08670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK51_RS08675	COG0159	tryptophan synthase activity
RK51_RS08680	COG0133	tryptophan synthase activity
RK51_RS08685	COG0134	indole-3-glycerol-phosphate synthase activity
RK51_RS08685	COG0135	phosphoribosylanthranilate isomerase activity
RK51_RS08690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RK51_RS08695	COG0512	Glutamine amidotransferase of anthranilate synthase
RK51_RS08700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RK51_RS08710	COG0613	PHP domain protein
RK51_RS08715	COG0009	L-threonylcarbamoyladenylate synthase
RK51_RS08725	COG1187	pseudouridine synthase activity
RK51_RS08735	COG3099	Belongs to the UPF0263 family
RK51_RS08740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RK51_RS08750	COG0417	DNA replication proofreading
RK51_RS08755	COG2197	response regulator
RK51_RS08760	COG0322	excinuclease ABC activity
RK51_RS08800	COG0019	diaminopimelate decarboxylase activity
RK51_RS08825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RK51_RS08830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RK51_RS08835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK51_RS08855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RK51_RS08865	COG0437	4 iron, 4 sulfur cluster binding
RK51_RS08870	COG3301	Polysulphide reductase, NrfD
RK51_RS08875	COG1138	Cytochrome C-type biogenesis protein
RK51_RS08885	COG4235	cytochrome complex assembly
RK51_RS08885	COG3088	subunit of a heme lyase
RK51_RS08895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK51_RS08920	COG2989	Protein conserved in bacteria
RK51_RS08925	COG3108	Peptidase M15
RK51_RS08930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK51_RS08945	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RK51_RS08970	COG1846	Transcriptional regulator
RK51_RS08975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK51_RS08980	COG0840	transmembrane signaling receptor activity
RK51_RS09000	COG1448	Aminotransferase
RK51_RS09025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_RS09035	COG0017	Asparaginyl-tRNA synthetase
RK51_RS09045	COG0720	synthase
RK51_RS09055	COG2200	EAL domain
RK51_RS09060	COG1760	l-serine dehydratase
RK51_RS09065	COG0814	amino acid
RK51_RS09070	COG0494	nUDIX hydrolase
RK51_RS09080	COG0784	Response regulator, receiver
RK51_RS09080	COG2205	protein histidine kinase activity
RK51_RS09085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RK51_RS09105	COG3106	COG3106 Predicted ATPase
RK51_RS09110	COG3768	UPF0283 membrane protein
RK51_RS09120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK51_RS09210	COG2026	Addiction module toxin, RelE StbE family
RK51_RS09255	COG1051	belongs to the nudix hydrolase family
RK51_RS09530	COG1192	Involved in chromosome partitioning
RK51_RS09610	COG0456	acetyltransferase
RK51_RS09625	COG0346	lactoylglutathione lyase activity
RK51_RS10050	COG1757	Na H antiporter
RK51_RS10055	COG0174	glutamine synthetase
RK51_RS10065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RK51_RS10070	COG1396	sequence-specific DNA binding
RK51_RS10070	COG1917	Cupin 2, conserved barrel domain protein
RK51_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
RK51_RS10080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK51_RS10090	COG2957	Belongs to the agmatine deiminase family
RK51_RS10095	COG1012	belongs to the aldehyde dehydrogenase family
RK51_RS10100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RK51_RS10105	COG1227	inorganic diphosphatase activity
RK51_RS10115	COG2200	EAL domain
RK51_RS10115	COG2771	luxR family
RK51_RS10130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RK51_RS10145	COG1846	Transcriptional regulator
RK51_RS10150	COG2315	Protein conserved in bacteria
RK51_RS10170	COG0110	maltose O-acetyltransferase activity
RK51_RS10200	COG3063	Type IV pilus biogenesis stability protein PilW
RK51_RS10205	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RK51_RS10220	COG0531	amino acid
RK51_RS10230	COG1560	Kdo2-lipid A biosynthetic process
RK51_RS10235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RK51_RS10240	COG1280	lysine exporter protein (LysE YggA)
RK51_RS10250	COG1115	amino acid carrier protein
RK51_RS10275	COG1368	sulfuric ester hydrolase activity
RK51_RS10280	COG0642	Histidine kinase
RK51_RS10285	COG0745	RESPONSE REGULATOR receiver
RK51_RS10295	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS10305	COG1022	Amp-dependent synthetase and ligase
RK51_RS10315	COG2113	Glycine betaine
RK51_RS10320	COG4176	ABC-type proline glycine betaine transport system permease component
RK51_RS10340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK51_RS10345	COG0456	acetyltransferase
RK51_RS10350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RK51_RS10355	COG0662	Cupin 2, conserved barrel domain protein
RK51_RS10360	COG0527	aspartate kinase activity
RK51_RS10365	COG1858	cytochrome C peroxidase
RK51_RS10380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_RS10395	COG3290	protein histidine kinase activity
RK51_RS10400	COG4565	transcriptional regulatory protein
RK51_RS10405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RK51_RS10410	COG0363	glucosamine-6-phosphate deaminase activity
RK51_RS10415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RK51_RS10440	COG3284	Transcriptional regulator
RK51_RS10445	COG1012	belongs to the aldehyde dehydrogenase family
RK51_RS10515	COG4669	(LipO)protein
RK51_RS10535	COG3177	Filamentation induced by cAMP protein fic
RK51_RS10585	COG4792	protein secretion
RK51_RS10590	COG4791	protein targeting
RK51_RS10595	COG4794	Type iii secretion
RK51_RS10600	COG4790	Type iii secretion
RK51_RS10670	COG0457	Tetratricopeptide repeat
RK51_RS10690	COG0730	response to heat
RK51_RS10720	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RK51_RS10725	COG0372	Belongs to the citrate synthase family
RK51_RS10735	COG2828	Protein conserved in bacteria
RK51_RS10760	COG0561	phosphatase activity
RK51_RS10765	COG0602	queuosine metabolic process
RK51_RS10770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RK51_RS10775	COG3706	GGDEF domain
RK51_RS10815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RK51_RS10820	COG0840	transmembrane signaling receptor activity
RK51_RS10825	COG1254	Belongs to the acylphosphatase family
RK51_RS10830	COG2920	part of a sulfur-relay system
RK51_RS10840	COG0670	Belongs to the BI1 family
RK51_RS10845	COG1126	abc transporter atp-binding protein
RK51_RS10850	COG0765	amino acid transport
RK51_RS10855	COG4597	amino acid ABC transporter
RK51_RS10860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_RS10880	COG1666	GTP binding
RK51_RS10885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RK51_RS10905	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
RK51_RS10905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RK51_RS10915	COG3008	intermembrane lipid transfer
RK51_RS10920	COG2995	paraquat-inducible protein a
RK51_RS10925	COG1132	(ABC) transporter
RK51_RS10930	COG1956	GAF domain-containing protein
RK51_RS10935	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
RK51_RS10950	COG0308	aminopeptidase N
RK51_RS10960	COG2902	Dehydrogenase
RK51_RS10965	COG0167	dihydroorotate dehydrogenase activity
RK51_RS10980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RK51_RS10980	COG0116	Belongs to the methyltransferase superfamily
RK51_RS10990	COG0488	(ABC) transporter
RK51_RS11005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK51_RS11010	COG1067	ATP-dependent peptidase activity
RK51_RS11015	COG3120	sequence-specific DNA binding
RK51_RS11120	COG2205	protein histidine kinase activity
RK51_RS11120	COG0784	Response regulator, receiver
RK51_RS11135	COG3278	Belongs to the heme-copper respiratory oxidase family
RK51_RS11150	COG2010	Cytochrome c
RK51_RS11160	COG2217	Heavy metal translocating P-type atpase
RK51_RS11175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK51_RS11180	COG0589	response to stress
RK51_RS11190	COG0037	tRNA processing
RK51_RS11210	COG3842	ATPase activity
RK51_RS11220	COG1177	transmembrane transport
RK51_RS11230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RK51_RS11235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RK51_RS11245	COG0004	ammonium transporteR
RK51_RS11285	COG0437	4 iron, 4 sulfur cluster binding
RK51_RS11290	COG3383	formate dehydrogenase (NAD+) activity
RK51_RS11290	COG0243	molybdopterin cofactor binding
RK51_RS11300	COG3381	protein complex oligomerization
RK51_RS11325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RK51_RS11330	COG0488	(ABC) transporter
RK51_RS11340	COG4191	Histidine kinase
RK51_RS11345	COG2204	response regulator
RK51_RS11365	COG3842	ATPase activity
RK51_RS11370	COG0746	molybdenum cofactor guanylyltransferase activity
RK51_RS11375	COG0303	'Molybdopterin
RK51_RS11385	COG1940	carbohydrate kinase activity
RK51_RS11390	COG3148	PFAM DTW domain containing protein
RK51_RS11425	COG3290	protein histidine kinase activity
RK51_RS11425	COG0840	transmembrane signaling receptor activity
RK51_RS11430	COG0791	NLP P60 protein
RK51_RS11440	COG3706	GGDEF domain
RK51_RS11445	COG2201	protein-glutamate methylesterase activity
RK51_RS11450	COG3001	Fructosamine kinase
RK51_RS11460	COG0307	riboflavin synthase, alpha
RK51_RS11465	COG0534	Mate efflux family protein
RK51_RS11475	COG1793	dna ligase
RK51_RS11510	COG2204	response regulator
RK51_RS11520	COG0438	transferase activity, transferring glycosyl groups
RK51_RS11555	COG0438	transferase activity, transferring glycosyl groups
RK51_RS11560	COG1215	transferase activity, transferring glycosyl groups
RK51_RS11565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RK51_RS11575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK51_RS11590	COG1643	Atp-dependent helicase
RK51_RS11595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RK51_RS11610	COG3302	dmso reductase anchor subunit
RK51_RS11615	COG0437	4 iron, 4 sulfur cluster binding
RK51_RS11620	COG0243	molybdopterin cofactor binding
RK51_RS11660	COG0443	Heat shock 70 kDa protein
RK51_RS11665	COG0443	Heat shock 70 kDa protein
RK51_RS11695	COG1132	(ABC) transporter
RK51_RS11700	COG1132	(ABC) transporter
RK51_RS11725	COG0814	amino acid
RK51_RS11740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RK51_RS11810	COG1522	sequence-specific DNA binding
RK51_RS11845	COG0515	serine threonine protein kinase
RK51_RS11870	COG3501	Rhs element vgr protein
RK51_RS11890	COG2885	chlorophyll binding
RK51_RS11910	COG0739	heme binding
RK51_RS11920	COG0861	Integral membrane protein TerC family
RK51_RS11930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RK51_RS11935	COG1328	CTP reductase activity
RK51_RS11940	COG1280	lysine exporter protein (LysE YggA)
RK51_RS11950	COG5001	Diguanylate cyclase
RK51_RS11950	COG3300	MHYT domain
RK51_RS11960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_RS11960	COG4191	Histidine kinase
RK51_RS11965	COG0471	metal ion transport
RK51_RS12000	COG0583	DNA-binding transcription factor activity
RK51_RS12005	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RK51_RS12235	COG1783	phage Terminase large subunit
RK51_RS12280	COG0557	exoribonuclease II activity
RK51_RS12285	COG1278	Cold shock
RK51_RS12395	COG0625	glutathione transferase activity
RK51_RS12405	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RK51_RS12420	COG2195	Cleaves the N-terminal amino acid of tripeptides
RK51_RS12430	COG0601	transmembrane transport
RK51_RS12435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_RS12440	COG0444	Belongs to the ABC transporter superfamily
RK51_RS12460	COG3291	Pkd domain containing protein
RK51_RS12475	COG1177	transmembrane transport
RK51_RS12480	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK51_RS12490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK51_RS12495	COG2423	ornithine cyclodeaminase activity
RK51_RS12515	COG3938	Belongs to the proline racemase family
RK51_RS12545	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
RK51_RS12550	COG1451	nucleotide metabolic process
RK51_RS12555	COG3475	LICD family
RK51_RS12560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RK51_RS12565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RK51_RS12585	COG0583	DNA-binding transcription factor activity
RK51_RS12605	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
RK51_RS12610	COG4139	cobalamin transport
RK51_RS12615	COG2988	succinylglutamate desuccinylase activity
RK51_RS12640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RK51_RS12645	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RK51_RS12650	COG0702	epimerase
RK51_RS12655	COG1823	symporter activity
RK51_RS12660	COG2925	Exonuclease
RK51_RS12665	COG1380	Effector of murein hydrolase LrgA
RK51_RS12670	COG1346	cytolysis
RK51_RS12675	COG0295	cytidine deaminase activity
RK51_RS12680	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RK51_RS12685	COG0500	methyltransferase
RK51_RS12695	COG0776	regulation of translation
RK51_RS12710	COG0072	phenylalanine-tRNA ligase activity
RK51_RS12710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK51_RS12715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RK51_RS12720	COG3706	GGDEF domain
RK51_RS12750	COG0393	Putative heavy-metal-binding
RK51_RS12760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RK51_RS12770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RK51_RS12785	COG2188	Transcriptional regulator
RK51_RS12790	COG1228	amidohydrolase
RK51_RS12795	COG0010	Belongs to the arginase family
RK51_RS12800	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RK51_RS12805	COG2986	histidine ammonia-lyase
RK51_RS12820	COG0247	lactate metabolic process
RK51_RS12820	COG0277	FAD linked oxidase domain protein
RK51_RS12855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RK51_RS12870	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RK51_RS12875	COG1643	Atp-dependent helicase
RK51_RS12880	COG0281	malic enzyme
RK51_RS12885	COG2949	membrane
RK51_RS12890	COG0471	metal ion transport
RK51_RS12915	COG0492	ferredoxin-NADP+ reductase activity
RK51_RS12920	COG4988	ABC transporter
RK51_RS12925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RK51_RS12930	COG3048	D-serine ammonia-lyase activity
RK51_RS12935	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RK51_RS12945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_RS12945	COG4191	Histidine kinase
RK51_RS12960	COG3070	regulator of competence-specific genes
RK51_RS12980	COG2431	L-lysine efflux transmembrane transporter activity
RK51_RS12990	COG0076	glutamate decarboxylase activity
RK51_RS12995	COG1737	Transcriptional regulator
RK51_RS13010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RK51_RS13015	COG3273	potassium ion transport
RK51_RS13015	COG2985	domain, Protein
RK51_RS13020	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RK51_RS13035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK51_RS13050	COG4181	ATPase activity
RK51_RS13055	COG0534	Mate efflux family protein
RK51_RS13060	COG0702	epimerase
RK51_RS13065	COG3005	denitrification pathway
RK51_RS13095	COG2814	Major facilitator Superfamily
RK51_RS13100	COG1187	pseudouridine synthase activity
RK51_RS13105	COG1061	Type III restriction enzyme res subunit
RK51_RS13125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RK51_RS13155	COG3313	Fe-S protein
RK51_RS13180	COG0493	'glutamate synthase
RK51_RS13190	COG0398	Pfam SNARE associated Golgi protein
RK51_RS13195	COG4134	Bacterial extracellular solute-binding protein
RK51_RS13200	COG4135	transport system, permease component
RK51_RS13205	COG4136	ATPase activity
RK51_RS13210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RK51_RS13225	COG3604	Transcriptional regulator
RK51_RS13230	COG1151	hydroxylamine reductase activity
RK51_RS13235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK51_RS13245	COG0564	pseudouridine synthase activity
RK51_RS13255	COG0733	neurotransmitter:sodium symporter activity
RK51_RS13265	COG0626	cystathionine gamma-synthase activity
RK51_RS13270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RK51_RS13275	COG5380	lipid catabolic process
RK51_RS13280	COG2818	Glycosylase
RK51_RS13295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_RS13300	COG1983	PspC domain protein
RK51_RS13310	COG1842	Phage shock protein A
RK51_RS13315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RK51_RS13330	COG4171	peptide transport system, permease
RK51_RS13340	COG4172	Belongs to the ABC transporter superfamily
RK51_RS13350	COG1227	inorganic diphosphatase activity
RK51_RS13365	COG0243	molybdopterin cofactor binding
RK51_RS13370	COG3005	denitrification pathway
RK51_RS13375	COG4459	periplasmic nitrate reductase
RK51_RS13380	COG0390	transport system, permease component
RK51_RS13390	COG2116	formate transmembrane transporter activity
RK51_RS13415	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RK51_RS13420	COG1435	thymidine kinase activity
RK51_RS13425	COG0215	cysteine-tRNA ligase activity
RK51_RS13430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RK51_RS13435	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK51_RS13440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RK51_RS13450	COG3012	SEC-C Motif Domain Protein
RK51_RS13455	COG0140	phosphoribosyl-ATP diphosphatase activity
RK51_RS13455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RK51_RS13460	COG0107	imidazoleglycerol-phosphate synthase activity
RK51_RS13465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RK51_RS13470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RK51_RS13475	COG0131	Imidazoleglycerol-phosphate dehydratase
RK51_RS13475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RK51_RS13480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RK51_RS13485	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RK51_RS13490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RK51_RS13505	COG1757	Na H antiporter
RK51_RS13515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_RS13525	COG0482	sulfurtransferase activity
RK51_RS13530	COG2915	High frequency lysogenization protein hflD homolog
RK51_RS13535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RK51_RS13560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RK51_RS13575	COG0300	oxidoreductase activity
RK51_RS13585	COG0501	Belongs to the peptidase M48B family
RK51_RS13595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RK51_RS13605	COG0156	8-amino-7-oxononanoate synthase activity
RK51_RS13610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RK51_RS13615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RK51_RS13620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RK51_RS13635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RK51_RS13640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RK51_RS13645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RK51_RS13650	COG1674	ftsk spoiiie
RK51_RS13660	COG0686	Belongs to the AlaDH PNT family
RK51_RS13670	COG0583	DNA-binding transcription factor activity
RK51_RS13685	COG3568	Endonuclease Exonuclease Phosphatase
RK51_RS13715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_RS13735	COG0840	transmembrane signaling receptor activity
RK51_RS13755	COG0328	RNA-DNA hybrid ribonuclease activity
RK51_RS13785	COG5002	protein histidine kinase activity
RK51_RS13785	COG0784	Response regulator, receiver
RK51_RS13795	COG0754	glutathionylspermidine amidase activity
RK51_RS13805	COG3766	membrane
RK51_RS13815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RK51_RS13820	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RK51_RS13825	COG2885	chlorophyll binding
RK51_RS13830	COG0823	Involved in the tonB-independent uptake of proteins
RK51_RS13845	COG0811	peptide transport
RK51_RS13850	COG0824	Thioesterase
RK51_RS13860	COG4890	Cyd operon protein YbgT
RK51_RS13865	COG1294	oxidase, subunit
RK51_RS13870	COG1271	oxidase subunit
RK51_RS13875	COG2255	four-way junction helicase activity
RK51_RS13880	COG0632	four-way junction helicase activity
RK51_RS13885	COG0840	transmembrane signaling receptor activity
RK51_RS13890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RK51_RS13895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RK51_RS13900	COG1801	Protein of unknown function DUF72
RK51_RS13905	COG4106	trans-aconitate 2-methyltransferase activity
RK51_RS13910	COG0500	methyltransferase
RK51_RS13920	COG0189	ligase activity
RK51_RS13920	COG4067	protein conserved in archaea
RK51_RS13940	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RK51_RS13945	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
RK51_RS13950	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
RK51_RS13955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK51_RS13960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RK51_RS13965	COG0745	RESPONSE REGULATOR receiver
RK51_RS13970	COG3381	protein complex oligomerization
RK51_RS13975	COG1609	Transcriptional regulator
RK51_RS13980	COG3070	regulator of competence-specific genes
RK51_RS14000	COG0297	glycogen (starch) synthase activity
RK51_RS14005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RK51_RS14010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RK51_RS14020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RK51_RS14030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RK51_RS14035	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RK51_RS14040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RK51_RS14050	COG0542	response to heat
RK51_RS14055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RK51_RS14060	COG1278	Cold shock
RK51_RS14070	COG1187	pseudouridine synthase activity
RK51_RS14075	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
RK51_RS14085	COG1199	ATP-dependent helicase activity
RK51_RS14090	COG0730	response to heat
RK51_RS14095	COG3923	Primosomal replication protein n
RK51_RS14105	COG0708	Exodeoxyribonuclease III
RK51_RS14150	COG1882	Formate acetyltransferase
RK51_RS14160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RK51_RS14170	COG3013	Belongs to the UPF0304 family
RK51_RS14180	COG2766	serine protein kinase
RK51_RS14185	COG2718	Belongs to the UPF0229 family
RK51_RS14190	COG2719	SpoVR family
RK51_RS14195	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RK51_RS14205	COG1663	tetraacyldisaccharide 4'-kinase activity
RK51_RS14210	COG1132	(ABC) transporter
RK51_RS14215	COG2333	competence protein COMEC
RK51_RS14215	COG0658	competence protein
RK51_RS14225	COG4591	ABC-type transport system involved in lipoprotein release permease component
RK51_RS14230	COG1136	(ABC) transporter
RK51_RS14235	COG4591	ABC-type transport system involved in lipoprotein release permease component
RK51_RS14245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RK51_RS14260	COG1252	NADH dehydrogenase
RK51_RS14270	COG3150	esterase
RK51_RS14295	COG0537	adenosine 5'-monophosphoramidase activity
RK51_RS14325	COG0516	GMP reductase activity
RK51_RS14325	COG0517	IMP dehydrogenase activity
RK51_RS14335	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RK51_RS14340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RK51_RS14345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RK51_RS14355	COG2199	diguanylate cyclase activity
RK51_RS14370	COG3126	Type III secretion system lipoprotein chaperone (YscW)
RK51_RS14375	COG1946	Acyl-CoA thioesterase
RK51_RS14385	COG1522	sequence-specific DNA binding
RK51_RS14415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_RS14465	COG0477	Major facilitator Superfamily
RK51_RS14470	COG2855	membrane
RK51_RS14495	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RK51_RS14500	COG0596	Alpha beta hydrolase
RK51_RS14505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RK51_RS14510	COG1169	isochorismate synthase
RK51_RS14515	COG0436	Aminotransferase
RK51_RS14520	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RK51_RS14525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RK51_RS14540	COG1555	photosystem II stabilization
RK51_RS14545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK51_RS14550	COG0776	regulation of translation
RK51_RS14555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RK51_RS14560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RK51_RS14570	COG0544	peptidyl-prolyl cis-trans isomerase activity
RK51_RS14580	COG2204	response regulator
RK51_RS14590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RK51_RS14595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RK51_RS14600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RK51_RS14605	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RK51_RS14625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK51_RS14630	COG0569	domain protein
RK51_RS14635	COG0513	Belongs to the DEAD box helicase family
RK51_RS14640	COG1253	flavin adenine dinucleotide binding
RK51_RS14670	COG0318	PFAM AMP-dependent synthetase and ligase
RK51_RS14670	COG0204	Acyl-transferase
RK51_RS14675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RK51_RS14680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RK51_RS14695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK51_RS14700	COG1216	Glycosyl transferase, family 2
RK51_RS14705	COG2986	histidine ammonia-lyase
RK51_RS14730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK51_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS14745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK51_RS14760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RK51_RS14765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK51_RS14770	COG0583	DNA-binding transcription factor activity
RK51_RS14775	COG2951	lytic endotransglycosylase activity
RK51_RS14780	COG3100	YcgL domain-containing protein
RK51_RS14785	COG0850	regulation of cytokinetic process
RK51_RS14790	COG2894	cell division
RK51_RS14795	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RK51_RS14800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RK51_RS14805	COG0318	PFAM AMP-dependent synthetase and ligase
RK51_RS14810	COG2267	carboxylic ester hydrolase activity
RK51_RS14825	COG1214	PFAM Peptidase M22, glycoprotease
RK51_RS14830	COG1199	ATP-dependent helicase activity
RK51_RS14835	COG0788	formyltetrahydrofolate deformylase activity
RK51_RS14840	COG3102	Protein conserved in bacteria
RK51_RS14850	COG0018	arginyl-trna synthetase
RK51_RS14870	COG1918	ferrous iron import across plasma membrane
RK51_RS14885	COG4977	sequence-specific DNA binding
RK51_RS14890	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RK51_RS14895	COG1121	(ABC) transporter
RK51_RS14900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RK51_RS14910	COG0045	succinate-CoA ligase (ADP-forming) activity
RK51_RS14915	COG0508	dehydrogenase complex catalyzes the overall conversion of
RK51_RS14920	COG0567	Dehydrogenase, E1 component
RK51_RS14925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RK51_RS14930	COG1053	succinate dehydrogenase
RK51_RS14935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RK51_RS14950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RK51_RS14960	COG0033	Phosphoglucomutase
RK51_RS14965	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
RK51_RS14970	COG0596	Alpha beta hydrolase
RK51_RS14990	COG0735	belongs to the Fur family
RK51_RS14995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK51_RS15000	COG2190	(PTS) system
RK51_RS15000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_RS15000	COG1263	PTS System
RK51_RS15010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RK51_RS15015	COG1846	Transcriptional regulator
RK51_RS15015	COG1940	carbohydrate kinase activity
RK51_RS15020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RK51_RS15020	COG4651	solute:proton antiporter activity
RK51_RS15025	COG0367	asparagine synthase
RK51_RS15030	COG0250	Participates in transcription elongation, termination and antitermination
RK51_RS15035	COG3104	oligopeptide transport
RK51_RS15040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RK51_RS15045	COG0563	adenylate kinase activity
RK51_RS15050	COG0326	Molecular chaperone. Has ATPase activity
RK51_RS15055	COG3710	Transcriptional regulator
RK51_RS15075	COG0622	Phosphoesterase
RK51_RS15105	COG1090	epimerase
RK51_RS15110	COG0300	oxidoreductase activity
RK51_RS15120	COG3118	belongs to the thioredoxin family
RK51_RS15125	COG0330	HflC and HflK could
RK51_RS15155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RK51_RS15160	COG3115	cell septum assembly
RK51_RS15165	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
RK51_RS15170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RK51_RS15180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_RS15185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RK51_RS15190	COG2190	(PTS) system
RK51_RS15200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS15205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS15215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS15225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS15235	COG3951	Flagellar rod assembly protein muramidase FlgJ
RK51_RS15235	COG1705	Flagellar rod assembly protein muramidase FlgJ
RK51_RS15240	COG1706	bacterial-type flagellum-dependent cell motility
RK51_RS15245	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RK51_RS15255	COG4787	bacterial-type flagellum-dependent cell motility
RK51_RS15265	COG1749	Flagellar hook protein flgE
RK51_RS15275	COG1558	bacterial-type flagellum-dependent cell motility
RK51_RS15280	COG1815	bacterial-type flagellum-dependent cell motility
RK51_RS15285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RK51_RS15290	COG0784	Response regulator, receiver
RK51_RS15290	COG0835	chemotaxis
RK51_RS15350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK51_RS15355	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
RK51_RS15370	COG2608	mercury ion transmembrane transporter activity
RK51_RS15370	COG2217	Heavy metal translocating P-type atpase
RK51_RS15415	COG2840	Smr protein MutS2
RK51_RS15420	COG1187	pseudouridine synthase activity
RK51_RS15430	COG0737	Belongs to the 5'-nucleotidase family
RK51_RS15435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RK51_RS15440	COG2912	Transglutaminase-like superfamily
RK51_RS15445	COG3094	Invasion gene expression up-regulator, SirB
RK51_RS15450	COG2890	protein-(glutamine-N5) methyltransferase activity
RK51_RS15455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RK51_RS15460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RK51_RS15475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RK51_RS15480	COG0193	aminoacyl-tRNA hydrolase activity
RK51_RS15485	COG0012	GTP binding
RK51_RS15590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RK51_RS15600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RK51_RS15605	COG1702	phosphate starvation-inducible protein PhoH
RK51_RS15610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RK51_RS15615	COG4535	Mg2 and Co2 transporter CorC
RK51_RS15620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RK51_RS15625	COG2888	peptidyl-tyrosine sulfation
RK51_RS15630	COG0495	leucyl-tRNA aminoacylation
RK51_RS15635	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
RK51_RS15640	COG1466	dna polymerase III delta subunit
RK51_RS15645	COG0799	negative regulation of ribosome biogenesis
RK51_RS15650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RK51_RS15655	COG0768	penicillin binding
RK51_RS15660	COG0772	Belongs to the SEDS family
RK51_RS15665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RK51_RS15670	COG1686	Belongs to the peptidase S11 family
RK51_RS15675	COG2921	Belongs to the UPF0250 family
RK51_RS15680	COG0321	lipoyl(octanoyl) transferase activity
RK51_RS15685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RK51_RS15690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RK51_RS15695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RK51_RS15710	COG0366	Alpha amylase catalytic
RK51_RS15715	COG1263	PTS System
RK51_RS15715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_RS15725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RK51_RS15735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RK51_RS15740	COG2011	ABC-type metal ion transport system permease component
RK51_RS15745	COG1464	Belongs to the NlpA lipoprotein family
RK51_RS15750	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
RK51_RS15760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RK51_RS15760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RK51_RS15775	COG1611	Belongs to the LOG family
RK51_RS15780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK51_RS15790	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
RK51_RS15795	COG2363	Small membrane protein
RK51_RS15810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK51_RS15810	COG0301	tRNA thio-modification
RK51_RS15815	COG2885	chlorophyll binding
RK51_RS15820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RK51_RS15825	COG1722	exodeoxyribonuclease VII activity
RK51_RS15830	COG0142	geranyltranstransferase activity
RK51_RS15835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RK51_RS15840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RK51_RS15845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RK51_RS15850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RK51_RS15870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK51_RS15870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK51_RS15875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RK51_RS15880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RK51_RS15885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RK51_RS15895	COG1073	alpha beta
RK51_RS15900	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RK51_RS15905	COG2252	PERMEase
RK51_RS15910	COG2195	Cleaves the N-terminal amino acid of tripeptides
RK51_RS15935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RK51_RS15935	COG0047	phosphoribosylformylglycinamidine synthase activity
RK51_RS15940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
RK51_RS15955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RK51_RS15980	COG4969	Belongs to the N-Me-Phe pilin family
RK51_RS15995	COG0484	heat shock protein binding
RK51_RS16000	COG0443	Heat shock 70 kDa protein
RK51_RS16005	COG1301	dicarboxylic acid transport
RK51_RS16010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RK51_RS16015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RK51_RS16025	COG0497	DNA recombination
RK51_RS16030	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK51_RS16035	COG2914	Belongs to the UPF0125 (RnfH) family
RK51_RS16040	COG2867	negative regulation of translational initiation
RK51_RS16045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RK51_RS16065	COG0583	DNA-binding transcription factor activity
RK51_RS16070	COG3153	acetyltransferase
RK51_RS16070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK51_RS16090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RK51_RS16095	COG2873	o-acetylhomoserine
RK51_RS16130	COG1115	amino acid carrier protein
RK51_RS16140	COG1584	GPR1 FUN34 yaaH family protein
RK51_RS16150	COG1757	Na H antiporter
RK51_RS16155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RK51_RS16155	COG0519	Catalyzes the synthesis of GMP from XMP
RK51_RS16160	COG0516	GMP reductase activity
RK51_RS16160	COG0517	IMP dehydrogenase activity
RK51_RS16165	COG1570	exodeoxyribonuclease VII activity
RK51_RS16180	COG1160	GTP binding
RK51_RS16185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK51_RS16190	COG2976	Protein conserved in bacteria
RK51_RS16195	COG0124	histidyl-tRNA synthetase
RK51_RS16200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RK51_RS16215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RK51_RS16220	COG0105	UTP biosynthetic process
RK51_RS16225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RK51_RS16230	COG2975	iron-sulfur cluster assembly
RK51_RS16235	COG0633	Ferredoxin
RK51_RS16240	COG0443	Heat shock 70 kDa protein
RK51_RS16245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RK51_RS16255	COG0822	iron-sulfur transferase activity
RK51_RS16260	COG1104	cysteine desulfurase activity
RK51_RS16265	COG1959	2 iron, 2 sulfur cluster binding
RK51_RS16275	COG0483	inositol monophosphate 1-phosphatase activity
RK51_RS16285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK51_RS16290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK51_RS16295	COG1862	Preprotein translocase
RK51_RS16300	COG0343	queuine tRNA-ribosyltransferase activity
RK51_RS16305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RK51_RS16320	COG0517	IMP dehydrogenase activity
RK51_RS16330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RK51_RS16340	COG0583	DNA-binding transcription factor activity
RK51_RS16345	COG0450	alkyl hydroperoxide reductase
RK51_RS16355	COG3142	Participates in the control of copper homeostasis
RK51_RS16365	COG0704	Plays a role in the regulation of phosphate uptake
RK51_RS16370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RK51_RS16375	COG0581	inorganic phosphate transmembrane transporter activity
RK51_RS16385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RK51_RS16390	COG0248	Ppx GppA phosphatase
RK51_RS16400	COG5002	protein histidine kinase activity
RK51_RS16405	COG0745	RESPONSE REGULATOR receiver
RK51_RS16415	COG2974	May be involved in recombination
RK51_RS16420	COG0826	peptidase U32
RK51_RS16425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RK51_RS16485	COG0542	response to heat
RK51_RS16495	COG0564	pseudouridine synthase activity
RK51_RS16500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK51_RS16505	COG0741	lytic transglycosylase activity
RK51_RS16510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RK51_RS16515	COG1605	Chorismate mutase
RK51_RS16515	COG0077	Prephenate dehydratase
RK51_RS16520	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
RK51_RS16525	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
RK51_RS16535	COG0488	(ABC) transporter
RK51_RS16550	COG0739	heme binding
RK51_RS16555	COG0287	Prephenate dehydrogenase
RK51_RS16555	COG1605	Chorismate mutase
RK51_RS16560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RK51_RS16565	COG1472	Belongs to the glycosyl hydrolase 3 family
RK51_RS16570	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RK51_RS16575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RK51_RS16590	COG1966	Carbon starvation protein
RK51_RS16595	COG3275	phosphorelay sensor kinase activity
RK51_RS16600	COG3279	Response regulator of the LytR AlgR family
RK51_RS16605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RK51_RS16610	COG1047	Peptidyl-prolyl cis-trans
RK51_RS16615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RK51_RS16620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RK51_RS16625	COG0196	riboflavin kinase activity
RK51_RS16630	COG0728	peptidoglycan biosynthetic process
RK51_RS16635	COG0268	Binds directly to 16S ribosomal RNA
RK51_RS16645	COG0640	Transcriptional regulator
RK51_RS16655	COG0583	DNA-binding transcription factor activity
RK51_RS16660	COG1283	sodium-dependent phosphate transmembrane transporter activity
RK51_RS16670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RK51_RS16675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RK51_RS16680	COG0730	response to heat
RK51_RS16690	COG0494	nUDIX hydrolase
RK51_RS16700	COG3066	DNA modification
RK51_RS16710	COG0667	Aldo Keto reductase
RK51_RS16725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RK51_RS16735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RK51_RS16740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK51_RS16745	COG4974	Belongs to the 'phage' integrase family
RK51_RS16750	COG0716	FMN binding
RK51_RS16760	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RK51_RS16765	COG0513	Belongs to the DEAD box helicase family
RK51_RS16770	COG3022	response to hydroperoxide
RK51_RS16775	COG1115	amino acid carrier protein
RK51_RS16790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RK51_RS16800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RK51_RS16805	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
RK51_RS16810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RK51_RS16815	COG0083	homoserine kinase activity
RK51_RS16830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RK51_RS16845	COG0745	RESPONSE REGULATOR receiver
RK51_RS16855	COG0784	Response regulator, receiver
RK51_RS16855	COG2198	Histidine kinase
RK51_RS16855	COG5002	protein histidine kinase activity
RK51_RS16860	COG5001	Diguanylate cyclase
RK51_RS16860	COG4251	negative regulation of phosphorylation
RK51_RS16860	COG3706	GGDEF domain
RK51_RS16860	COG2203	Gaf domain
RK51_RS16865	COG1242	4 iron, 4 sulfur cluster binding
RK51_RS16870	COG0070	glutamate synthase
RK51_RS16870	COG0069	glutamate synthase activity
RK51_RS16870	COG0067	glutamate synthase
RK51_RS16900	COG3842	ATPase activity
RK51_RS16910	COG1175	transmembrane transport
RK51_RS16915	COG3833	ABC-type maltose transport systems, permease component
RK51_RS17005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RK51_RS17060	COG2199	diguanylate cyclase activity
RK51_RS17060	COG2202	Pas domain
RK51_RS17060	COG2200	EAL domain
RK51_RS17165	COG4789	Type iii secretion
RK51_RS17170	COG4792	protein secretion
RK51_RS17200	COG3710	Transcriptional regulator
RK51_RS17215	COG4790	Type iii secretion
RK51_RS17315	COG2916	Histone family protein nucleoid-structuring protein H-NS
RK51_RS17335	COG2207	Transcriptional regulator
RK51_RS17345	COG4172	Belongs to the ABC transporter superfamily
RK51_RS17350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_RS17360	COG0747	negative chemotaxis
RK51_RS17380	COG0804	urea catabolic process
RK51_RS17465	COG0183	Belongs to the thiolase family
RK51_RS17485	COG3746	phosphate-selective porin O and P
RK51_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS17530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RK51_RS17540	COG0625	glutathione transferase activity
RK51_RS17555	COG1686	Belongs to the peptidase S11 family
RK51_RS17580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RK51_RS17600	COG1278	Cold shock
RK51_RS17605	COG1741	Belongs to the pirin family
RK51_RS17610	COG4667	esterase of the alpha-beta hydrolase superfamily
RK51_RS17645	COG0673	inositol 2-dehydrogenase activity
RK51_RS17650	COG2194	sulfuric ester hydrolase activity
RK51_RS17655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RK51_RS17665	COG2205	protein histidine kinase activity
RK51_RS17670	COG0745	RESPONSE REGULATOR receiver
RK51_RS17675	COG4221	oxidoreductase activity
RK51_RS17695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK51_RS17715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK51_RS17725	COG2814	Major facilitator Superfamily
RK51_RS17740	COG1418	mRNA catabolic process
RK51_RS17750	COG0402	S-adenosylhomocysteine deaminase activity
RK51_RS17755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RK51_RS17765	COG2239	Acts as a magnesium transporter
RK51_RS17770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RK51_RS17785	COG0531	amino acid
RK51_RS17795	COG1522	sequence-specific DNA binding
RK51_RS17820	COG2205	protein histidine kinase activity
RK51_RS17820	COG5002	protein histidine kinase activity
RK51_RS17820	COG0784	Response regulator, receiver
RK51_RS17825	COG0673	inositol 2-dehydrogenase activity
RK51_RS17830	COG0534	Mate efflux family protein
RK51_RS17835	COG2926	Belongs to the UPF0265 family
RK51_RS17850	COG3132	Protein of unknown function, DUF480
RK51_RS17855	COG2827	Endonuclease containing a URI domain
RK51_RS17860	COG1879	ABC-type sugar transport system periplasmic component
RK51_RS17865	COG0784	Response regulator, receiver
RK51_RS17865	COG2205	protein histidine kinase activity
RK51_RS17875	COG1566	PFAM secretion protein HlyD family protein
RK51_RS17895	COG1522	sequence-specific DNA binding
RK51_RS17925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK51_RS17930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK51_RS17950	COG0183	Belongs to the thiolase family
RK51_RS17970	COG3005	denitrification pathway
RK51_RS17980	COG0243	molybdopterin cofactor binding
RK51_RS17990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RK51_RS17995	COG3850	Histidine kinase
RK51_RS18000	COG2197	response regulator
RK51_RS18015	COG2195	Cleaves the N-terminal amino acid of tripeptides
RK51_RS18035	COG0840	transmembrane signaling receptor activity
RK51_RS18045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK51_RS18060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RK51_RS18065	COG2814	Major facilitator Superfamily
RK51_RS18075	COG0840	transmembrane signaling receptor activity
RK51_RS18080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RK51_RS18085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RK51_RS18115	COG2897	thiosulfate sulfurtransferase activity
RK51_RS18135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RK51_RS18145	COG0302	gtp cyclohydrolase
RK51_RS18150	COG1914	H( )-stimulated, divalent metal cation uptake system
RK51_RS18160	COG0038	chloride channel
RK51_RS18175	COG4989	oxidoreductase activity
RK51_RS18190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RK51_RS18190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RK51_RS18195	COG0516	GMP reductase activity
RK51_RS18200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK51_RS18270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RK51_RS18270	COG0674	pyruvate-flavodoxin oxidoreductase activity
RK51_RS18275	COG1013	pyruvate-flavodoxin oxidoreductase activity
RK51_RS18280	COG3474	cytochrome
RK51_RS18290	COG0789	Transcriptional regulator
RK51_RS18295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK51_RS18300	COG0384	phenazine biosynthesis protein PhzF
RK51_RS18310	COG1294	oxidase, subunit
RK51_RS18315	COG1271	oxidase subunit
RK51_RS18320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_RS18325	COG0110	maltose O-acetyltransferase activity
RK51_RS18335	COG3264	Mechanosensitive ion channel
RK51_RS18335	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RK51_RS18350	COG2205	protein histidine kinase activity
RK51_RS18350	COG3437	response regulator, receiver
RK51_RS18350	COG3850	Histidine kinase
RK51_RS18350	COG4999	Histidine kinase
RK51_RS18360	COG4770	biotin carboxylase activity
RK51_RS18370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RK51_RS18375	COG1960	acyl-CoA dehydrogenase activity
RK51_RS18385	COG0183	Belongs to the thiolase family
RK51_RS18395	COG1960	acyl-CoA dehydrogenase activity
RK51_RS18400	COG1024	Enoyl-CoA hydratase
RK51_RS18425	COG3706	GGDEF domain
RK51_RS18430	COG1309	transcriptional regulator
RK51_RS18435	COG1012	belongs to the aldehyde dehydrogenase family
RK51_RS18450	COG4176	ABC-type proline glycine betaine transport system permease component
RK51_RS18455	COG0517	IMP dehydrogenase activity
RK51_RS18455	COG4175	Glycine betaine
RK51_RS18470	COG0330	HflC and HflK could
RK51_RS18485	COG5001	Diguanylate cyclase
RK51_RS18485	COG3300	MHYT domain
RK51_RS18505	COG0784	Response regulator, receiver
RK51_RS18505	COG2205	protein histidine kinase activity
RK51_RS18565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RK51_RS18570	COG5001	Diguanylate cyclase
RK51_RS18575	COG1869	D-ribose catabolic process
RK51_RS18580	COG1129	ABC transporter
RK51_RS18585	COG1172	Belongs to the binding-protein-dependent transport system permease family
RK51_RS18590	COG1879	ABC-type sugar transport system periplasmic component
RK51_RS18595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_RS18600	COG1609	Transcriptional regulator
RK51_RS18615	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
RK51_RS18635	COG0745	RESPONSE REGULATOR receiver
RK51_RS18650	COG1785	Belongs to the alkaline phosphatase family
RK51_RS18680	COG0814	amino acid
RK51_RS18690	COG0243	molybdopterin cofactor binding
RK51_RS18695	COG1648	precorrin-2 dehydrogenase activity
RK51_RS18695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RK51_RS18715	COG3707	response regulator
RK51_RS18725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RK51_RS18730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK51_RS18735	COG1116	anion transmembrane transporter activity
RK51_RS18740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK51_RS18740	COG2146	nitrite reductase [NAD(P)H] activity
RK51_RS18795	COG2815	serine threonine protein kinase
RK51_RS18795	COG0515	serine threonine protein kinase
RK51_RS18835	COG0631	protein serine/threonine phosphatase activity
RK51_RS18905	COG0420	3'-5' exonuclease activity
RK51_RS18910	COG0419	ATPase involved in DNA repair
RK51_RS18930	COG3040	lipid binding
RK51_RS18940	COG2814	Major facilitator Superfamily
RK51_RS18950	COG1288	antiporter activity
RK51_RS18965	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RK51_RS18980	COG2425	protein containing a von Willebrand factor type A (vWA) domain
RK51_RS19000	COG0583	DNA-binding transcription factor activity
RK51_RS19005	COG0277	FAD linked oxidase domain protein
RK51_RS19025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RK51_RS19070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK51_RS19070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK51_RS19120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK51_RS19125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK51_RS19135	COG2116	formate transmembrane transporter activity
RK51_RS19155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RK51_RS19190	COG0534	Mate efflux family protein
RK51_RS19195	COG3292	Two component regulator propeller
RK51_RS19195	COG2205	protein histidine kinase activity
RK51_RS19195	COG0745	RESPONSE REGULATOR receiver
RK51_RS19205	COG3118	belongs to the thioredoxin family
RK51_RS19210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RK51_RS19235	COG2271	Major facilitator Superfamily
RK51_RS19240	COG3851	Histidine kinase
RK51_RS19245	COG2197	response regulator
RK51_RS19255	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RK51_RS19260	COG0583	DNA-binding transcription factor activity
RK51_RS19270	COG0243	molybdopterin cofactor binding
RK51_RS19300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_RS19315	COG1328	CTP reductase activity
RK51_RS19320	COG0602	queuosine metabolic process
RK51_RS19325	COG0534	Mate efflux family protein
RK51_RS19345	COG0189	ligase activity
RK51_RS19345	COG4067	protein conserved in archaea
RK51_RS19355	COG3111	PFAM Bacterial OB fold (BOF) protein
RK51_RS19360	COG1492	cobalamin metabolic process
RK51_RS19365	COG0725	ABC transporter, periplasmic molybdate-binding protein
RK51_RS19370	COG4149	molybdate abc transporter
RK51_RS19375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RK51_RS19385	COG5001	Diguanylate cyclase
RK51_RS19385	COG2203	Gaf domain
RK51_RS19385	COG3706	GGDEF domain
RK51_RS19385	COG4251	negative regulation of phosphorylation
RK51_RS19410	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RK51_RS19415	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RK51_RS19440	COG3140	Belongs to the UPF0181 family
RK51_RS19445	COG0589	response to stress
RK51_RS19460	COG0023	Translation Initiation Factor
RK51_RS19470	COG1181	Belongs to the D-alanine--D-alanine ligase family
RK51_RS19480	COG0045	succinate-CoA ligase (ADP-forming) activity
RK51_RS19480	COG1042	CoA-binding domain protein
RK51_RS19480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK51_RS19485	COG0583	DNA-binding transcription factor activity
RK51_RS19490	COG1629	transport
RK51_RS19490	COG4771	TonB-dependent receptor
RK51_RS19500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RK51_RS19505	COG5001	Diguanylate cyclase
RK51_RS19505	COG5002	protein histidine kinase activity
RK51_RS19505	COG3447	MASE1 domain protein
RK51_RS19510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RK51_RS19515	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RK51_RS19520	COG1984	allophanate hydrolase subunit 2
RK51_RS19530	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RK51_RS19535	COG4181	ATPase activity
RK51_RS19545	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RK51_RS19550	COG5001	Diguanylate cyclase
RK51_RS19550	COG3300	MHYT domain
RK51_RS19560	COG0484	heat shock protein binding
RK51_RS19585	COG4533	DNA binding
RK51_RS19595	COG2050	protein possibly involved in aromatic compounds catabolism
RK51_RS19610	COG2067	long-chain fatty acid transport protein
RK51_RS19615	COG2267	carboxylic ester hydrolase activity
RK51_RS19635	COG0861	Integral membrane protein TerC family
RK51_RS19640	COG0737	Belongs to the 5'-nucleotidase family
RK51_RS19645	COG3593	DNA synthesis involved in DNA repair
RK51_RS19655	COG0583	DNA-binding transcription factor activity
RK51_RS19660	COG2116	formate transmembrane transporter activity
RK51_RS19665	COG2353	YceI-like domain
RK51_RS19670	COG3038	cytochrome b561
RK51_RS19685	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RK51_RS19690	COG0513	Belongs to the DEAD box helicase family
RK51_RS19695	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
RK51_RS19705	COG0840	transmembrane signaling receptor activity
RK51_RS19715	COG0546	phosphoglycolate phosphatase activity
RK51_RS19725	COG0784	Response regulator, receiver
RK51_RS19725	COG3437	response regulator, receiver
RK51_RS19745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_RS19750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RK51_RS19755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RK51_RS19770	COG2207	Transcriptional regulator
RK51_RS19775	COG1979	alcohol dehydrogenase
RK51_RS19800	COG2271	Major facilitator Superfamily
RK51_RS19805	COG0469	pyruvate kinase activity
RK51_RS19810	COG1126	abc transporter atp-binding protein
RK51_RS19815	COG0765	amino acid transport
RK51_RS19820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_RS19825	COG0765	amino acid transport
RK51_RS19830	COG2199	diguanylate cyclase activity
RK51_RS19830	COG2203	Gaf domain
RK51_RS19830	COG2200	EAL domain
RK51_RS19850	COG1609	Transcriptional regulator
RK51_RS19855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_RS19855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_RS19860	COG1105	Belongs to the carbohydrate kinase PfkB family
RK51_RS19865	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RK51_RS19865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_RS19865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_RS19905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RK51_RS19910	COG0509	glycine decarboxylation via glycine cleavage system
RK51_RS19915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RK51_RS19915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RK51_RS19930	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RK51_RS19935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RK51_RS19940	COG0583	DNA-binding transcription factor activity
RK51_RS19945	COG2176	DNA-directed DNA polymerase activity
RK51_RS19990	COG0242	peptide deformylase activity
RK51_RS20020	COG2239	Acts as a magnesium transporter
RK51_RS20040	COG0346	lactoylglutathione lyase activity
RK51_RS20045	COG1902	pentaerythritol trinitrate reductase activity
RK51_RS20065	COG5642	Protein of unknown function (DUF2384)
RK51_RS20070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RK51_RS20090	COG4565	transcriptional regulatory protein
RK51_RS20095	COG3290	protein histidine kinase activity
RK51_RS20100	COG0471	metal ion transport
RK51_RS20130	COG2076	Multidrug Resistance protein
RK51_RS20145	COG0671	phosphoesterase, PA-phosphatase related
RK51_RS20160	COG2962	Rard protein
RK51_RS20180	COG0784	Response regulator, receiver
RK51_RS20180	COG0835	chemotaxis
RK51_RS20205	COG2197	response regulator
RK51_RS20215	COG3706	GGDEF domain
RK51_RS20220	COG2197	response regulator
RK51_RS20225	COG5001	Diguanylate cyclase
RK51_RS20225	COG3300	MHYT domain
RK51_RS20240	COG0583	DNA-binding transcription factor activity
RK51_RS20245	COG0583	DNA-binding transcription factor activity
RK51_RS20305	COG4964	Belongs to the GSP D family
RK51_RS20330	COG2207	Transcriptional regulator
RK51_RS20350	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RK51_RS20370	COG0456	acetyltransferase
RK51_RS20370	COG1214	PFAM Peptidase M22, glycoprotease
RK51_RS20380	COG3069	C4-dicarboxylate transmembrane transporter activity
RK51_RS20385	COG1704	LemA family
RK51_RS20390	COG0501	Belongs to the peptidase M48B family
RK51_RS20420	COG0641	radical SAM
RK51_RS20440	COG3111	PFAM Bacterial OB fold (BOF) protein
RK51_RS20445	COG1597	lipid kinase activity
RK51_RS20450	COG0583	DNA-binding transcription factor activity
RK51_RS20455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK51_RS20455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK51_RS20485	COG0714	Associated with various cellular activities
RK51_RS20490	COG0641	radical SAM
RK51_RS20495	COG3119	arylsulfatase activity
RK51_RS20510	COG3119	arylsulfatase activity
RK51_RS20515	COG3119	arylsulfatase activity
RK51_RS20520	COG0745	RESPONSE REGULATOR receiver
RK51_RS20535	COG0784	Response regulator, receiver
RK51_RS20535	COG2198	Histidine kinase
RK51_RS20535	COG2205	protein histidine kinase activity
RK51_RS20540	COG1879	ABC-type sugar transport system periplasmic component
RK51_RS20545	COG1803	Methylglyoxal synthase
RK51_RS20550	COG0210	DNA helicase
RK51_RS20555	COG1289	transmembrane transporter activity
RK51_RS20590	COG1629	transport
RK51_RS20590	COG4771	TonB-dependent receptor
RK51_RS20605	COG0789	Transcriptional regulator
RK51_RS20610	COG4604	ABC transporter, ATP-binding protein
RK51_RS20615	COG4605	iron ion homeostasis
RK51_RS20620	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK51_RS20625	COG4607	ABC-type enterochelin transport system periplasmic component
RK51_RS20650	COG2847	Copper chaperone PCu(A)C
RK51_RS20655	COG0443	Heat shock 70 kDa protein
RK51_RS20690	COG0625	glutathione transferase activity
RK51_RS20705	COG4160	amino acid transport
RK51_RS20710	COG4215	(ABC) transporter
RK51_RS20715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_RS20720	COG1126	abc transporter atp-binding protein
RK51_RS20730	COG1902	pentaerythritol trinitrate reductase activity
RK51_RS20735	COG0109	protoheme IX farnesyltransferase activity
RK51_RS20740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RK51_RS20745	COG1845	cytochrome c oxidase, subunit III
RK51_RS20750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RK51_RS20755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RK51_RS20760	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS20770	COG1024	Enoyl-CoA hydratase
RK51_RS20775	COG1024	Enoyl-CoA hydratase
RK51_RS20790	COG0183	Belongs to the thiolase family
RK51_RS20800	COG1960	acyl-CoA dehydrogenase activity
RK51_RS20805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RK51_RS20810	COG1024	Enoyl-CoA hydratase
RK51_RS20820	COG5413	integral membrane protein
RK51_RS20835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RK51_RS20845	COG5001	Diguanylate cyclase
RK51_RS20850	COG0513	Belongs to the DEAD box helicase family
RK51_RS20855	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
RK51_RS20870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RK51_RS20890	COG0641	radical SAM
RK51_RS20915	COG0840	transmembrane signaling receptor activity
RK51_RS20920	COG1119	ATPase activity
RK51_RS20925	COG2200	EAL domain
RK51_RS20945	COG0513	Belongs to the DEAD box helicase family
RK51_RS20950	COG0523	cobalamin synthesis protein
RK51_RS20960	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RK51_RS20970	COG0133	tryptophan synthase activity
RK51_RS20975	COG4628	conserved protein (DUF2132)
RK51_RS20980	COG0513	Belongs to the DEAD box helicase family
RK51_RS20985	COG3530	Putative quorum-sensing-regulated virulence factor
RK51_RS21010	COG2154	pterin-4-alpha-carbinolamine dehydratase
RK51_RS21015	COG3186	Phenylalanine-4-hydroxylase
RK51_RS21020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK51_RS21025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK51_RS21060	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RK51_RS21065	COG1454	alcohol dehydrogenase
RK51_RS21070	COG2133	pyrroloquinoline quinone binding
RK51_RS21080	COG0783	Belongs to the Dps family
RK51_RS21085	COG0840	transmembrane signaling receptor activity
RK51_RS21095	COG1136	(ABC) transporter
RK51_RS21095	COG0577	efflux transmembrane transporter activity
RK51_RS21115	COG2199	diguanylate cyclase activity
RK51_RS21130	COG3036	rescue of stalled ribosome
RK51_RS21135	COG1278	Cold shock
RK51_RS21170	COG0545	Peptidyl-prolyl cis-trans isomerase
RK51_RS21175	COG0109	protoheme IX farnesyltransferase activity
RK51_RS21180	COG1612	heme a metabolic process
RK51_RS21205	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RK51_RS21215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RK51_RS21220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RK51_RS21230	COG1280	lysine exporter protein (LysE YggA)
RK51_RS21235	COG2207	Transcriptional regulator
RK51_RS21265	COG0697	spore germination
RK51_RS21290	COG2814	Major facilitator Superfamily
RK51_RS21295	COG0583	DNA-binding transcription factor activity
RK51_RS21300	COG5001	Diguanylate cyclase
RK51_RS21305	COG0739	heme binding
RK51_RS21330	COG3314	Sporulation integral membrane protein YlbJ
RK51_RS21345	COG0814	amino acid
RK51_RS21365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RK51_RS21370	COG1072	(Pantothenic acid kinase))
RK51_RS21380	COG1063	alcohol dehydrogenase
RK51_RS21385	COG2213	PTS system mannitol-specific
RK51_RS21390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_RS21410	COG0798	PFAM Bile acid sodium symporter
RK51_RS21420	COG1881	PFAM PEBP family protein
RK51_RS21430	COG2706	6-phosphogluconolactonase activity
RK51_RS21450	COG1131	(ABC) transporter
RK51_RS21455	COG0842	Transport permease protein
RK51_RS21470	COG3383	formate dehydrogenase (NAD+) activity
RK51_RS21495	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_RS21525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK51_RS21535	COG2067	long-chain fatty acid transport protein
RK51_RS21545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_RS21555	COG1505	serine-type exopeptidase activity
RK51_RS21560	COG0488	(ABC) transporter
RK51_RS21565	COG0589	response to stress
RK51_RS21570	COG2249	NAD(P)H dehydrogenase (quinone) activity
RK51_RS21590	COG0366	Alpha amylase catalytic
RK51_RS21600	COG4934	collagen metabolic process
RK51_RS21615	COG0583	DNA-binding transcription factor activity
RK51_RS21625	COG0783	Belongs to the Dps family
RK51_RS21630	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RK51_RS21665	COG2814	Major facilitator Superfamily
RK51_RS21680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK51_RS21685	COG0835	chemotaxis
RK51_RS21685	COG0784	Response regulator, receiver
RK51_RS21695	COG0748	coenzyme F420 binding
RK51_RS21700	COG3721	Heme iron utilization protein
RK51_RS21710	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RK51_RS21715	COG0811	peptide transport
RK51_RS21720	COG0848	biopolymer transport protein
RK51_RS21730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK51_RS21735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RK51_RS21780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RK51_RS21785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RK51_RS21790	COG3217	Mosc domain protein beta barrel domain protein
RK51_RS21790	COG3217	Mosc domain protein beta barrel domain protein
RK51_RS21790	COG0633	Ferredoxin
RK51_RS21790	COG0633	Ferredoxin
RK51_RS21800	COG0401	homolog of Blt101
RK51_RS21810	COG0418	dihydroorotase activity
RK51_RS21815	COG2354	Protein conserved in bacteria
RK51_RS21845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RK51_RS21845	COG2207	Transcriptional regulator
RK51_RS21850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_RS21895	COG0513	Belongs to the DEAD box helicase family
RK51_RS21905	COG0583	DNA-binding transcription factor activity
RK51_RS21920	COG1902	pentaerythritol trinitrate reductase activity
RK51_RS21925	COG1063	alcohol dehydrogenase
RK51_RS21935	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS21950	COG3122	Protein conserved in bacteria
RK51_RS21970	COG0583	DNA-binding transcription factor activity
RK51_RS21975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RK51_RS21980	COG0252	asparaginase activity
RK51_RS21985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RK51_RS21990	COG0574	Belongs to the PEP-utilizing enzyme family
RK51_RS21990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RK51_RS22010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RK51_RS22030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_RS22050	COG3706	GGDEF domain
RK51_RS22070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK51_RS22100	COG3842	ATPase activity
RK51_RS22155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK51_RS22205	COG0583	DNA-binding transcription factor activity
RK51_RS22215	COG4948	Mandelate Racemase Muconate Lactonizing
RK51_RS22250	COG1342	Belongs to the UPF0251 family
RK51_RS22260	COG3015	lipoprotein NlpE involved in copper resistance
RK51_RS22270	COG3713	MltA-interacting MipA family protein
RK51_RS22285	COG0583	DNA-binding transcription factor activity
RK51_RS22310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RK51_RS22320	COG1335	isochorismatase
RK51_RS22330	COG0753	catalase activity
RK51_RS22340	COG1349	DNA-binding transcription factor activity
RK51_RS22345	COG0346	lactoylglutathione lyase activity
RK51_RS22360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_RS22365	COG2070	2-Nitropropane dioxygenase
RK51_RS22370	COG0737	Belongs to the 5'-nucleotidase family
RK51_RS22380	COG1309	transcriptional regulator
RK51_RS22400	COG1280	lysine exporter protein (LysE YggA)
RK51_RS22415	COG0459	protein refolding
RK51_RS22420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RK51_RS22430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK51_RS22455	COG1304	FMN binding
RK51_RS22475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS22490	COG1706	bacterial-type flagellum-dependent cell motility
RK51_RS22495	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RK51_RS22500	COG4786	Flagellar basal body rod
RK51_RS22505	COG4787	bacterial-type flagellum-dependent cell motility
RK51_RS22510	COG1749	Flagellar hook protein flgE
RK51_RS22515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RK51_RS22520	COG1558	bacterial-type flagellum-dependent cell motility
RK51_RS22525	COG1815	bacterial-type flagellum-dependent cell motility
RK51_RS22545	COG0741	lytic transglycosylase activity
RK51_RS22555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RK51_RS22575	COG1760	l-serine dehydratase
RK51_RS22580	COG3104	oligopeptide transport
RK51_RS22600	COG0583	DNA-binding transcription factor activity
RK51_RS22615	COG2866	Carboxypeptidase
RK51_RS22620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK51_RS22630	COG2990	Protein conserved in bacteria
RK51_RS22655	COG3842	ATPase activity
RK51_RS22665	COG1840	ABC-type Fe3 transport system, periplasmic component
RK51_RS22670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RK51_RS22675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RK51_RS22680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK51_RS22685	COG1609	Transcriptional regulator
RK51_RS22715	COG3240	lipase activity
RK51_RS22725	COG0577	efflux transmembrane transporter activity
RK51_RS22725	COG1136	(ABC) transporter
RK51_RS22730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_RS22735	COG2067	long-chain fatty acid transport protein
RK51_RS22745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RK51_RS22760	COG1011	Hydrolase
RK51_RS22800	COG0110	maltose O-acetyltransferase activity
RK51_RS22805	COG1765	OsmC-like protein
RK51_RS22810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK51_RS22810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK51_RS22825	COG3046	protein related to deoxyribodipyrimidine photolyase
RK51_RS22830	COG0415	Belongs to the DNA photolyase family
RK51_RS22835	COG3706	GGDEF domain
RK51_RS22850	COG0840	transmembrane signaling receptor activity
RK51_RS22855	COG3706	GGDEF domain
RK51_RS22870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK51_RS22890	COG3033	Beta-eliminating lyase
RK51_RS22900	COG0579	oxidoreductase
RK51_RS22925	COG1114	Component of the transport system for branched-chain amino acids
RK51_RS22930	COG3706	GGDEF domain
RK51_RS22975	COG0583	DNA-binding transcription factor activity
RK51_RS22980	COG0189	ligase activity
RK51_RS22985	COG4067	protein conserved in archaea
RK51_RS22985	COG0189	ligase activity
RK51_RS22995	COG1166	arginine decarboxylase activity
RK51_RS23000	COG0010	Belongs to the arginase family
RK51_RS23005	COG2814	Major facilitator Superfamily
RK51_RS23010	COG1770	oligopeptidase
RK51_RS23025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RK51_RS23030	COG1121	(ABC) transporter
RK51_RS23035	COG0803	Belongs to the bacterial solute-binding protein 9 family
RK51_RS23080	COG0848	biopolymer transport protein
RK51_RS23085	COG0811	peptide transport
RK51_RS23090	COG0811	peptide transport
RK51_RS23110	COG0745	RESPONSE REGULATOR receiver
RK51_RS23115	COG0039	L-malate dehydrogenase activity
RK51_RS23120	COG0584	glycerophosphoryl diester phosphodiesterase
RK51_RS23130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RK51_RS23190	COG1901	pseudouridine methyltransferase
RK51_RS23195	COG0312	modulator of DNA gyrase
RK51_RS23200	COG0312	modulator of DNA gyrase
RK51_RS23210	COG0351	phosphomethylpyrimidine kinase
RK51_RS23215	COG1116	anion transmembrane transporter activity
RK51_RS23220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK51_RS23225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RK51_RS23230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RK51_RS23235	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RK51_RS23240	COG0352	thiamine-phosphate diphosphorylase activity
RK51_RS23250	COG0243	molybdopterin cofactor binding
RK51_RS23255	COG3005	denitrification pathway
RK51_RS23265	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS23280	COG0454	-acetyltransferase
RK51_RS23280	COG0456	acetyltransferase
RK51_RS23300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_RS23305	COG1929	Belongs to the glycerate kinase type-1 family
RK51_RS23310	COG2610	gluconate transmembrane transporter activity
RK51_RS23315	COG3835	regulator
RK51_RS23340	COG0546	phosphoglycolate phosphatase activity
RK51_RS23355	COG0583	DNA-binding transcription factor activity
RK51_RS23365	COG0583	DNA-binding transcription factor activity
RK51_RS23375	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RK51_RS23380	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RK51_RS23380	COG3408	Glycogen debranching enzyme
RK51_RS23410	COG3047	cAMP biosynthetic process
RK51_RS23415	COG1357	PFAM Pentapeptide repeats (8 copies)
RK51_RS23445	COG2375	cellular response to nickel ion
RK51_RS23450	COG0823	Involved in the tonB-independent uptake of proteins
RK51_RS23455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK51_RS23475	COG0800	Aldolase
RK51_RS23480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_RS23495	COG1917	Cupin 2, conserved barrel domain protein
RK51_RS23505	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_RS23510	COG1414	Transcriptional regulator
RK51_RS23525	COG0583	DNA-binding transcription factor activity
RK51_RS23530	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RK51_RS23535	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RK51_RS23550	COG2199	diguanylate cyclase activity
RK51_RS23560	COG0561	phosphatase activity
RK51_RS23565	COG0583	DNA-binding transcription factor activity
RK51_RS23580	COG0564	pseudouridine synthase activity
RK51_RS23585	COG0534	Mate efflux family protein
RK51_RS23595	COG5001	Diguanylate cyclase
RK51_RS23605	COG3123	guanosine phosphorylase activity
RK51_RS23645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RK51_RS23655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RK51_RS23660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RK51_RS23675	COG2259	Doxx family
RK51_RS23680	COG1741	Belongs to the pirin family
RK51_RS23700	COG0363	glucosamine-6-phosphate deaminase activity
RK51_RS23715	COG0786	glutamate:sodium symporter activity
RK51_RS23720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_RS23725	COG1131	(ABC) transporter
RK51_RS23735	COG0786	glutamate:sodium symporter activity
RK51_RS23770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RK51_RS23780	COG3279	Response regulator of the LytR AlgR family
RK51_RS23785	COG3275	phosphorelay sensor kinase activity
RK51_RS23805	COG1136	(ABC) transporter
RK51_RS23820	COG0772	Belongs to the SEDS family
RK51_RS23825	COG0217	transcriptional regulatory protein
RK51_RS23850	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RK51_RS23850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK51_RS23860	COG0444	Belongs to the ABC transporter superfamily
RK51_RS23865	COG4608	Belongs to the ABC transporter superfamily
RK51_RS23895	COG1444	tRNA N-acetyltransferase activity
RK51_RS23915	COG3340	Belongs to the peptidase S51 family
RK51_RS23920	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RK51_RS23925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_RS23925	COG1263	PTS System
RK51_RS23930	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RK51_RS23950	COG4166	transmembrane transport
RK51_RS23995	COG0259	pyridoxamine-phosphate oxidase activity
RK51_RS24025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK51_RS24070	COG1132	(ABC) transporter
RK51_RS24080	COG2207	Transcriptional regulator
RK51_RS24105	COG0800	Aldolase
RK51_RS24110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_RS24115	COG1904	glucuronate isomerase
RK51_RS24120	COG0246	Mannitol dehydrogenase
RK51_RS24130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RK51_RS24140	COG2186	Transcriptional regulator
RK51_RS24150	COG0513	Belongs to the DEAD box helicase family
RK51_RS24155	COG2258	MOSC domain
RK51_RS24170	COG1486	melibiose metabolic process
RK51_RS24175	COG0583	DNA-binding transcription factor activity
RK51_RS24195	COG1595	DNA-templated transcription, initiation
RK51_RS24230	COG3634	alkyl hydroperoxide reductase activity
RK51_RS24240	COG1846	Transcriptional regulator
RK51_RS24245	COG1764	response to oxidative stress
RK51_RS24270	COG2160	L-arabinose isomerase activity
RK51_RS24280	COG1069	ribulokinase activity
RK51_RS24285	COG1879	ABC-type sugar transport system periplasmic component
RK51_RS24290	COG1129	ABC transporter
RK51_RS24295	COG1172	Belongs to the binding-protein-dependent transport system permease family
RK51_RS24300	COG0826	peptidase U32
RK51_RS24330	COG1653	transport
RK51_RS24335	COG0019	diaminopimelate decarboxylase activity
RK51_RS24340	COG4264	IucA IucC family
RK51_RS24365	COG4772	TonB-dependent receptor
RK51_RS24370	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RK51_RS24375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK51_RS24380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK51_RS24385	COG1120	ATPase activity
RK51_RS24390	COG0840	transmembrane signaling receptor activity
RK51_RS24395	COG0612	Peptidase, M16
RK51_RS24405	COG0739	heme binding
RK51_RS24430	COG4580	involved in the transport of maltose and maltodextrins
RK51_RS24455	COG2356	endonuclease I
RK51_RS24475	COG1982	Orn Lys Arg decarboxylase major
RK51_RS24480	COG0531	amino acid
RK51_RS24490	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RK51_RS24500	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RK51_RS24505	COG1162	GTPase activity
RK51_RS24510	COG1263	PTS System
RK51_RS24510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_RS24520	COG1999	signal sequence binding
RK51_RS24535	COG2909	trisaccharide binding
RK51_RS24550	COG0058	SHG alpha-glucan phosphorylase activity
RK51_RS24555	COG1640	4-alpha-glucanotransferase
RK51_RS24560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RK51_RS24565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RK51_RS24570	COG0366	Alpha amylase catalytic
RK51_RS24585	COG3366	ferrous iron transmembrane transporter activity
RK51_RS24590	COG0700	Nucleoside recognition
RK51_RS24595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RK51_RS24600	COG3339	Conserved Protein
RK51_RS24605	COG1301	dicarboxylic acid transport
RK51_RS24615	COG0583	DNA-binding transcription factor activity
RK51_RS24630	COG3206	protein involved in exopolysaccharide biosynthesis
RK51_RS24630	COG0489	protein tyrosine kinase activity
RK51_RS24650	COG2095	MarC family integral membrane protein
RK51_RS24655	COG4667	esterase of the alpha-beta hydrolase superfamily
RK51_RS24660	COG3397	chitin binding
RK51_RS24665	COG1054	Belongs to the UPF0176 family
RK51_RS24680	COG1686	Belongs to the peptidase S11 family
RK51_RS24705	COG0583	DNA-binding transcription factor activity
RK51_RS24710	COG4628	conserved protein (DUF2132)
RK51_RS24720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK51_RS24730	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
RK51_RS24735	COG0628	permease
RK51_RS24780	COG2814	Major facilitator Superfamily
RK51_RS24795	COG0454	-acetyltransferase
RK51_RS24805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RK51_RS24810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RK51_RS24815	COG1882	Formate acetyltransferase
RK51_RS24865	COG1360	Flagellar Motor Protein
RK51_RS24870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RK51_RS24875	COG1191	sigma factor activity
RK51_RS24880	COG1580	Controls the rotational direction of flagella during chemotaxis
RK51_RS24895	COG1516	flagellar protein fliS
RK51_RS24900	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RK51_RS24910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_RS24925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RK51_RS24935	COG1987	bacterial-type flagellum assembly
RK51_RS25015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RK51_RS25035	COG0346	lactoylglutathione lyase activity
RK51_RS25070	COG0745	RESPONSE REGULATOR receiver
RK51_RS25090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_RS25100	COG0156	8-amino-7-oxononanoate synthase activity
RK51_RS25105	COG1063	alcohol dehydrogenase
RK51_RS25140	COG0668	transmembrane transport
RK51_RS25150	COG1304	FMN binding
RK51_RS25155	COG1620	l-lactate permease
RK51_RS25160	COG0583	DNA-binding transcription factor activity
RK51_RS25165	COG1505	serine-type exopeptidase activity
RK51_RS25170	COG4172	Belongs to the ABC transporter superfamily
RK51_RS25180	COG1067	ATP-dependent peptidase activity
RK51_RS25210	COG1247	-acetyltransferase
RK51_RS25215	COG0437	4 iron, 4 sulfur cluster binding
RK51_RS25220	COG0348	domain, Protein
RK51_RS25235	COG1122	ATPase activity
RK51_RS25240	COG4720	Psort location CytoplasmicMembrane, score
RK51_RS25245	COG1566	PFAM secretion protein HlyD family protein
RK51_RS25255	COG3706	GGDEF domain
RK51_RS25270	COG0813	purine-nucleoside phosphorylase activity
RK51_RS25280	COG3272	Protein of unknown function (DUF1722)
RK51_RS25285	COG0789	Transcriptional regulator
RK51_RS25290	COG0415	Belongs to the DNA photolyase family
RK51_RS25295	COG1376	ErfK ybiS ycfS ynhG family protein
RK51_RS25295	COG1388	LysM domain
RK51_RS25305	COG0513	Belongs to the DEAD box helicase family
RK51_RS25310	COG1770	oligopeptidase
RK51_RS25315	COG4771	TonB-dependent receptor
RK51_RS25345	COG0573	inorganic phosphate transmembrane transporter activity
RK51_RS25350	COG0581	inorganic phosphate transmembrane transporter activity
RK51_RS25355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RK51_RS25370	COG2304	oxidoreductase activity
RK51_RS25390	COG0714	Associated with various cellular activities
RK51_RS25400	COG0840	transmembrane signaling receptor activity
RK51_RS25410	COG2197	response regulator
RK51_RS25460	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RK51_RS25465	COG1120	ATPase activity
RK51_RS25470	COG4774	siderophore transport
RK51_RS25475	COG1132	(ABC) transporter
RK51_RS25480	COG2205	protein histidine kinase activity
RK51_RS25490	COG0569	domain protein
RK51_RS25495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK51_RS25500	COG3300	MHYT domain
RK51_RS25500	COG5001	Diguanylate cyclase
RK51_RS25505	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
RK51_RS25510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK51_RS25525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_RS25525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_RS25525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_RS25530	COG2207	Transcriptional regulator
RK51_RS25540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_RS25545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_RS25550	COG2084	Dehydrogenase
RK51_RS25555	COG0753	catalase activity
RK51_RS25565	COG2130	NADP-dependent
RK51_RS25570	COG1309	transcriptional regulator
RK51_RS25575	COG3097	Belongs to the UPF0267 family