locus-tag	class	description
M5598_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5598_RS00010	COG0592	DNA-directed DNA polymerase activity
M5598_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5598_RS00020	COG0187	DNA topoisomerase II activity
M5598_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
M5598_RS00035	COG3977	Valine--pyruvate aminotransferase
M5598_RS00040	COG0366	Alpha amylase catalytic
M5598_RS00045	COG0751	glycine-tRNA ligase activity
M5598_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
M5598_RS00055	COG2119	membrane
M5598_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
M5598_RS00080	COG0604	alcohol dehydrogenase
M5598_RS00085	COG0183	Belongs to the thiolase family
M5598_RS00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5598_RS00090	COG1024	Enoyl-CoA hydratase
M5598_RS00095	COG1739	Uncharacterized protein family UPF0029
M5598_RS00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5598_RS00165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5598_RS00170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M5598_RS00180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5598_RS00185	COG2104	thiamine diphosphate biosynthetic process
M5598_RS00190	COG2022	thiamine diphosphate biosynthetic process
M5598_RS00200	COG0006	proline dipeptidase activity
M5598_RS00200	COG0006	proline dipeptidase activity
M5598_RS00230	COG3220	belongs to the UPF0276 family
M5598_RS00240	COG0210	DNA helicase
M5598_RS00245	COG0405	Gamma-glutamyltransferase
M5598_RS00250	COG1280	lysine exporter protein (LysE YggA)
M5598_RS00260	COG2962	Rard protein
M5598_RS00265	COG0514	ATP-dependent DNA helicase (RecQ)
M5598_RS00275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M5598_RS00280	COG0248	Ppx GppA phosphatase
M5598_RS00285	COG0513	Belongs to the DEAD box helicase family
M5598_RS00290	COG3118	belongs to the thioredoxin family
M5598_RS00305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M5598_RS00310	COG0633	Ferredoxin
M5598_RS00350	COG3071	HemY protein
M5598_RS00355	COG2959	enzyme of heme biosynthesis
M5598_RS00360	COG1587	Uroporphyrinogen-III synthase
M5598_RS00365	COG0181	hydroxymethylbilane synthase activity
M5598_RS00370	COG3072	Adenylate cyclase
M5598_RS00375	COG1965	Belongs to the frataxin family
M5598_RS00385	COG0019	diaminopimelate decarboxylase activity
M5598_RS00390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M5598_RS00400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M5598_RS00405	COG1011	Hydrolase
M5598_RS00410	COG2200	EAL domain
M5598_RS00410	COG3287	FIST C domain
M5598_RS00410	COG2199	diguanylate cyclase activity
M5598_RS00415	COG3148	PFAM DTW domain containing protein
M5598_RS00430	COG0561	phosphatase activity
M5598_RS00435	COG2267	carboxylic ester hydrolase activity
M5598_RS00440	COG1280	lysine exporter protein (LysE YggA)
M5598_RS00445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5598_RS00450	COG0640	Transcriptional regulator
M5598_RS00455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5598_RS00505	COG2095	MarC family integral membrane protein
M5598_RS00515	COG0742	ribosomal rna small subunit methyltransferase
M5598_RS00520	COG0552	protein localization to endoplasmic reticulum
M5598_RS00525	COG2884	Cell division ATP-binding protein ftsE
M5598_RS00530	COG2177	Part of the ABC transporter FtsEX involved in
M5598_RS00540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5598_RS00545	COG0705	Rhomboid family
M5598_RS00550	COG1580	Controls the rotational direction of flagella during chemotaxis
M5598_RS00555	COG3161	chorismate lyase activity
M5598_RS00560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M5598_RS00565	COG2937	Belongs to the GPAT DAPAT family
M5598_RS00570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M5598_RS00575	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M5598_RS00580	COG0534	Mate efflux family protein
M5598_RS00585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5598_RS00600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5598_RS00605	COG4206	TonB-dependent receptor
M5598_RS00615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5598_RS00680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5598_RS00690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M5598_RS00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5598_RS00730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5598_RS00735	COG0250	Participates in transcription elongation, termination and antitermination
M5598_RS00740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M5598_RS00745	COG0081	regulation of translation
M5598_RS00750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M5598_RS00755	COG0222	ribosome binding
M5598_RS00760	COG0085	RNA polymerase activity
M5598_RS00765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M5598_RS00770	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
M5598_RS00775	COG2816	NAD+ diphosphatase activity
M5598_RS00790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5598_RS00795	COG1573	uracil-dna glycosylase
M5598_RS00800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5598_RS00810	COG1253	flavin adenine dinucleotide binding
M5598_RS00825	COG0151	Belongs to the GarS family
M5598_RS00830	COG0138	bifunctional purine biosynthesis protein purh
M5598_RS00835	COG0789	Transcriptional regulator
M5598_RS00845	COG3710	Transcriptional regulator
M5598_RS00850	COG0531	amino acid
M5598_RS00855	COG1982	Orn Lys Arg decarboxylase major
M5598_RS00910	COG3706	GGDEF domain
M5598_RS00915	COG0488	(ABC) transporter
M5598_RS00920	COG2814	Major facilitator Superfamily
M5598_RS00925	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M5598_RS00930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5598_RS00935	COG2264	protein methyltransferase activity
M5598_RS00940	COG0439	Biotin carboxylase
M5598_RS00945	COG0511	ligase activity, forming carbon-carbon bonds
M5598_RS00950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M5598_RS00955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5598_RS00970	COG2814	Major facilitator Superfamily
M5598_RS00975	COG2205	protein histidine kinase activity
M5598_RS00975	COG0784	Response regulator, receiver
M5598_RS00995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5598_RS01005	COG3263	regulation of cellular component size
M5598_RS01015	COG4232	protein-disulfide reductase activity
M5598_RS01020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M5598_RS01025	COG1027	Aspartate ammonia-lyase
M5598_RS01030	COG3030	protein affecting phage T7 exclusion by the F plasmid
M5598_RS01035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M5598_RS01045	COG2205	protein histidine kinase activity
M5598_RS01050	COG0745	RESPONSE REGULATOR receiver
M5598_RS01055	COG3678	ATP-independent chaperone mediated protein folding
M5598_RS01065	COG0205	6-phosphofructokinase activity
M5598_RS01070	COG0534	Mate efflux family protein
M5598_RS01080	COG0459	protein refolding
M5598_RS01095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5598_RS01100	COG1509	lysine 2,3-aminomutase activity
M5598_RS01105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5598_RS01115	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M5598_RS01120	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M5598_RS01125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5598_RS01130	COG1053	succinate dehydrogenase
M5598_RS01135	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M5598_RS01155	COG4942	peptidase
M5598_RS01160	COG1045	serine acetyltransferase
M5598_RS01165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M5598_RS01170	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M5598_RS01175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5598_RS01180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M5598_RS01195	COG0471	metal ion transport
M5598_RS01200	COG0688	phosphatidylethanolamine metabolic process
M5598_RS01205	COG1162	GTPase activity
M5598_RS01210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M5598_RS01280	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M5598_RS01285	COG0802	atpase or kinase
M5598_RS01295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M5598_RS01300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M5598_RS01310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5598_RS01315	COG0330	HflC and HflK could
M5598_RS01320	COG0330	HflC and HflK could
M5598_RS01325	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M5598_RS01330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5598_RS01335	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M5598_RS01340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5598_RS01340	COG1017	nitric oxide dioxygenase activity
M5598_RS01345	COG1959	2 iron, 2 sulfur cluster binding
M5598_RS01350	COG0557	exoribonuclease II activity
M5598_RS01355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5598_RS01360	COG0546	phosphoglycolate phosphatase activity
M5598_RS01365	COG0180	Tryptophanyl-tRNA synthetase
M5598_RS01380	COG0512	Glutamine amidotransferase of anthranilate synthase
M5598_RS01385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5598_RS01395	COG1012	belongs to the aldehyde dehydrogenase family
M5598_RS01405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5598_RS01410	COG3954	Phosphoribulokinase
M5598_RS01415	COG3089	Belongs to the UPF0270 family
M5598_RS01420	COG0429	hydrolase of the alpha beta-hydrolase fold
M5598_RS01430	COG0488	(ABC) transporter
M5598_RS01435	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5598_RS01450	COG1047	Peptidyl-prolyl cis-trans
M5598_RS01455	COG1446	asparaginase
M5598_RS01460	COG2900	Belongs to the SlyX family
M5598_RS01470	COG0545	Peptidyl-prolyl cis-trans isomerase
M5598_RS01475	COG2964	Protein conserved in bacteria
M5598_RS01480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M5598_RS01485	COG2923	Belongs to the DsrF TusC family
M5598_RS01490	COG2168	tRNA wobble position uridine thiolation
M5598_RS01500	COG0049	tRNA binding
M5598_RS01505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5598_RS01510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5598_RS01515	COG2906	2 iron, 2 sulfur cluster binding
M5598_RS01525	COG0281	malic enzyme
M5598_RS01535	COG0626	cystathionine gamma-synthase activity
M5598_RS01540	COG0527	aspartate kinase activity
M5598_RS01540	COG0460	homoserine dehydrogenase
M5598_RS01545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M5598_RS01555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M5598_RS01560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5598_RS01565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M5598_RS01570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5598_RS01575	COG0137	argininosuccinate synthase activity
M5598_RS01580	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5598_RS01580	COG0165	Argininosuccinate lyase
M5598_RS01590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5598_RS01590	COG0678	peroxiredoxin activity
M5598_RS01600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M5598_RS01630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M5598_RS01635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M5598_RS01645	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5598_RS01650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5598_RS01655	COG0360	Binds together with S18 to 16S ribosomal RNA
M5598_RS01660	COG2965	DNA replication, synthesis of RNA primer
M5598_RS01670	COG0359	binds to the 23S rRNA
M5598_RS01685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5598_RS01695	COG0432	Pfam Uncharacterised protein family UPF0047
M5598_RS01700	COG0166	Belongs to the GPI family
M5598_RS01710	COG0735	belongs to the Fur family
M5598_RS01715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5598_RS01735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5598_RS01740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5598_RS01745	COG0175	sulfate reduction
M5598_RS01810	COG0646	methionine synthase
M5598_RS01810	COG1410	methionine synthase
M5598_RS01815	COG0527	aspartate kinase activity
M5598_RS01820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M5598_RS01830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5598_RS01845	COG0629	single-stranded DNA binding
M5598_RS01850	COG2199	diguanylate cyclase activity
M5598_RS01850	COG2200	EAL domain
M5598_RS01875	COG3267	Type II secretory pathway component ExeA
M5598_RS01875	COG3409	Peptidoglycan-binding domain 1 protein
M5598_RS01885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_RS01890	COG1459	type II secretion system
M5598_RS01900	COG2165	general secretion pathway protein
M5598_RS01935	COG1077	Cell shape determining protein MreB Mrl
M5598_RS01940	COG1792	Involved in formation and maintenance of cell shape
M5598_RS01945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M5598_RS01950	COG0424	maF-like protein
M5598_RS01960	COG3164	Protein of unknown function
M5598_RS01965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5598_RS01970	COG0312	modulator of DNA gyrase
M5598_RS01975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M5598_RS01980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5598_RS01990	COG0564	pseudouridine synthase activity
M5598_RS01995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5598_RS02000	COG3028	Belongs to the UPF0307 family
M5598_RS02005	COG0312	modulator of DNA gyrase
M5598_RS02010	COG2239	Acts as a magnesium transporter
M5598_RS02015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS02020	COG1660	Displays ATPase and GTPase activities
M5598_RS02025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS02030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5598_RS02040	COG1137	ATPase activity
M5598_RS02045	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M5598_RS02055	COG0517	IMP dehydrogenase activity
M5598_RS02055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M5598_RS02065	COG1127	ABC transporter
M5598_RS02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M5598_RS02075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M5598_RS02080	COG2854	intermembrane phospholipid transfer
M5598_RS02090	COG5007	Belongs to the BolA IbaG family
M5598_RS02095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5598_RS02100	COG0204	Acyl-transferase
M5598_RS02105	COG0251	oxidation-reduction process
M5598_RS02110	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M5598_RS02115	COG0540	Belongs to the ATCase OTCase family
M5598_RS02125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M5598_RS02130	COG2235	arginine
M5598_RS02155	COG0525	valine-tRNA ligase activity
M5598_RS02160	COG2927	DNA polymerase III (CHI subunit)
M5598_RS02165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M5598_RS02170	COG0795	lipopolysaccharide-transporting ATPase activity
M5598_RS02175	COG0795	lipopolysaccharide-transporting ATPase activity
M5598_RS02280	COG0726	polysaccharide deacetylase
M5598_RS02285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5598_RS02290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5598_RS02295	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5598_RS02300	COG1486	melibiose metabolic process
M5598_RS02305	COG3394	polysaccharide catabolic process
M5598_RS02315	COG3437	response regulator, receiver
M5598_RS02360	COG1012	belongs to the aldehyde dehydrogenase family
M5598_RS02430	COG0741	lytic transglycosylase activity
M5598_RS02435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M5598_RS02445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5598_RS02455	COG2066	Belongs to the glutaminase family
M5598_RS02460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5598_RS02465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5598_RS02475	COG1872	DUF167
M5598_RS02480	COG0762	integral membrane protein
M5598_RS02485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5598_RS02490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M5598_RS02505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M5598_RS02510	COG1678	Uncharacterized ACR, COG1678
M5598_RS02515	COG0189	ligase activity
M5598_RS02520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5598_RS02525	COG2356	endonuclease I
M5598_RS02530	COG3091	SprT-like family
M5598_RS02540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M5598_RS02545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5598_RS02550	COG0583	DNA-binding transcription factor activity
M5598_RS02555	COG4771	TonB-dependent receptor
M5598_RS02560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5598_RS02565	COG0126	phosphoglycerate kinase activity
M5598_RS02570	COG0191	fructose-bisphosphate aldolase activity
M5598_RS02575	COG0668	transmembrane transport
M5598_RS02580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M5598_RS02590	COG0583	DNA-binding transcription factor activity
M5598_RS02600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5598_RS02605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M5598_RS02610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M5598_RS02620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M5598_RS02625	COG3079	Belongs to the UPF0149 family
M5598_RS02630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5598_RS02635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5598_RS02650	COG0354	folic acid binding
M5598_RS02655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M5598_RS02660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M5598_RS02665	COG1595	DNA-templated transcription, initiation
M5598_RS02670	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M5598_RS02680	COG3086	response to oxidative stress
M5598_RS02685	COG0481	GTPase activity
M5598_RS02695	COG0571	ribonuclease III activity
M5598_RS02700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5598_RS02705	COG1381	Involved in DNA repair and RecF pathway recombination
M5598_RS02710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M5598_RS02715	COG0736	holo-[acyl-carrier-protein] synthase activity
M5598_RS02725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5598_RS02730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5598_RS02735	COG3956	TIGRFAM MazG family protein
M5598_RS02740	COG0504	CTP synthase activity
M5598_RS02745	COG0148	phosphopyruvate hydratase activity
M5598_RS02750	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M5598_RS02755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M5598_RS02760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M5598_RS02765	COG0585	pseudouridine synthase activity
M5598_RS02770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M5598_RS02775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M5598_RS02785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M5598_RS02790	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M5598_RS02795	COG1546	Belongs to the CinA family
M5598_RS02800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M5598_RS02805	COG2137	regulation of response to DNA damage stimulus
M5598_RS02810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M5598_RS02815	COG0527	aspartate kinase activity
M5598_RS02880	COG3630	sodium ion export across plasma membrane
M5598_RS02885	COG0511	ligase activity, forming carbon-carbon bonds
M5598_RS02885	COG5016	pyruvate
M5598_RS02890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M5598_RS02900	COG1238	metal cluster binding
M5598_RS02905	COG0612	Peptidase, M16
M5598_RS02910	COG2918	glutathione biosynthetic process
M5598_RS02920	COG1854	S-ribosylhomocysteine lyase activity
M5598_RS02925	COG4536	flavin adenine dinucleotide binding
M5598_RS02930	COG4137	Cytochrome C assembly protein
M5598_RS02935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M5598_RS02940	COG0228	four-way junction DNA binding
M5598_RS02945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M5598_RS02950	COG0336	Belongs to the RNA methyltransferase TrmD family
M5598_RS02955	COG0335	large ribosomal subunit rRNA binding
M5598_RS02960	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M5598_RS02965	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M5598_RS02970	COG0237	dephospho-CoA kinase activity
M5598_RS02980	COG1459	type II secretion system
M5598_RS02985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_RS02995	COG0157	Belongs to the NadC ModD family
M5598_RS03005	COG2186	Transcriptional regulator
M5598_RS03010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M5598_RS03015	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5598_RS03020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5598_RS03035	COG0288	reversible hydration of carbon dioxide
M5598_RS03040	COG0659	secondary active sulfate transmembrane transporter activity
M5598_RS03045	COG1131	(ABC) transporter
M5598_RS03050	COG0842	Transport permease protein
M5598_RS03055	COG1560	Kdo2-lipid A biosynthetic process
M5598_RS03060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M5598_RS03065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M5598_RS03070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5598_RS03080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5598_RS03090	COG1489	DNA binding
M5598_RS03095	COG1643	Atp-dependent helicase
M5598_RS03100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5598_RS03105	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5598_RS03110	COG1049	propionate catabolic process, 2-methylcitrate cycle
M5598_RS03115	COG3112	Uncharacterised protein family (UPF0231)
M5598_RS03125	COG0004	ammonium transporteR
M5598_RS03130	COG1840	ABC-type Fe3 transport system, periplasmic component
M5598_RS03140	COG3842	ATPase activity
M5598_RS03145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5598_RS03160	COG2971	BadF BadG BcrA BcrD
M5598_RS03170	COG4608	Belongs to the ABC transporter superfamily
M5598_RS03175	COG0444	Belongs to the ABC transporter superfamily
M5598_RS03180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5598_RS03190	COG0747	negative chemotaxis
M5598_RS03195	COG0784	Response regulator, receiver
M5598_RS03195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_RS03195	COG2198	Histidine kinase
M5598_RS03195	COG2205	protein histidine kinase activity
M5598_RS03200	COG2813	Specifically methylates the guanine in position
M5598_RS03205	COG0628	permease
M5598_RS03210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5598_RS03215	COG0316	Belongs to the HesB IscA family
M5598_RS03225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_RS03230	COG0739	heme binding
M5598_RS03235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5598_RS03240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M5598_RS03245	COG0047	phosphoribosylformylglycinamidine synthase activity
M5598_RS03245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5598_RS03270	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5598_RS03275	COG2252	PERMEase
M5598_RS03280	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M5598_RS03285	COG1073	alpha beta
M5598_RS03295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5598_RS03300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M5598_RS03305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M5598_RS03310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5598_RS03310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5598_RS03330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5598_RS03335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M5598_RS03340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5598_RS03345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M5598_RS03350	COG0142	geranyltranstransferase activity
M5598_RS03355	COG1722	exodeoxyribonuclease VII activity
M5598_RS03360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5598_RS03365	COG2885	chlorophyll binding
M5598_RS03370	COG0301	tRNA thio-modification
M5598_RS03370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5598_RS03375	COG0583	DNA-binding transcription factor activity
M5598_RS03385	COG2363	Small membrane protein
M5598_RS03390	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M5598_RS03400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_RS03405	COG1611	Belongs to the LOG family
M5598_RS03420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M5598_RS03420	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M5598_RS03430	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M5598_RS03435	COG1464	Belongs to the NlpA lipoprotein family
M5598_RS03440	COG2011	ABC-type metal ion transport system permease component
M5598_RS03445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5598_RS03450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M5598_RS03460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_RS03460	COG1263	PTS System
M5598_RS03465	COG0366	Alpha amylase catalytic
M5598_RS03475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5598_RS03480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5598_RS03485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5598_RS03490	COG0321	lipoyl(octanoyl) transferase activity
M5598_RS03495	COG2921	Belongs to the UPF0250 family
M5598_RS03500	COG1686	Belongs to the peptidase S11 family
M5598_RS03505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M5598_RS03510	COG0772	Belongs to the SEDS family
M5598_RS03515	COG0768	penicillin binding
M5598_RS03520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M5598_RS03525	COG0799	negative regulation of ribosome biogenesis
M5598_RS03530	COG1466	dna polymerase III delta subunit
M5598_RS03535	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M5598_RS03540	COG0495	leucyl-tRNA aminoacylation
M5598_RS03545	COG2888	peptidyl-tyrosine sulfation
M5598_RS03550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M5598_RS03555	COG4535	Mg2 and Co2 transporter CorC
M5598_RS03560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M5598_RS03565	COG1702	phosphate starvation-inducible protein PhoH
M5598_RS03570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5598_RS03575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5598_RS03685	COG0012	GTP binding
M5598_RS03690	COG0193	aminoacyl-tRNA hydrolase activity
M5598_RS03695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M5598_RS03700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M5598_RS03705	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M5598_RS03710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M5598_RS03715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5598_RS03720	COG2890	protein-(glutamine-N5) methyltransferase activity
M5598_RS03725	COG3094	Invasion gene expression up-regulator, SirB
M5598_RS03730	COG2912	Transglutaminase-like superfamily
M5598_RS03735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M5598_RS03740	COG0737	Belongs to the 5'-nucleotidase family
M5598_RS03750	COG1187	pseudouridine synthase activity
M5598_RS03755	COG2840	Smr protein MutS2
M5598_RS03790	COG2217	Heavy metal translocating P-type atpase
M5598_RS03790	COG2608	mercury ion transmembrane transporter activity
M5598_RS03800	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M5598_RS03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5598_RS03855	COG0784	Response regulator, receiver
M5598_RS03855	COG0835	chemotaxis
M5598_RS03860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M5598_RS03865	COG1815	bacterial-type flagellum-dependent cell motility
M5598_RS03870	COG1558	bacterial-type flagellum-dependent cell motility
M5598_RS03880	COG1749	Flagellar hook protein flgE
M5598_RS03885	COG4787	bacterial-type flagellum-dependent cell motility
M5598_RS03895	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M5598_RS03900	COG1706	bacterial-type flagellum-dependent cell motility
M5598_RS03905	COG1705	Flagellar rod assembly protein muramidase FlgJ
M5598_RS03905	COG3951	Flagellar rod assembly protein muramidase FlgJ
M5598_RS03915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS03920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS03925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS03935	COG2190	(PTS) system
M5598_RS03940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5598_RS03945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS03950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5598_RS03955	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M5598_RS03960	COG3115	cell septum assembly
M5598_RS03965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5598_RS03985	COG0330	HflC and HflK could
M5598_RS03990	COG2194	sulfuric ester hydrolase activity
M5598_RS04015	COG1215	transferase activity, transferring glycosyl groups
M5598_RS04020	COG1215	transferase activity, transferring glycosyl groups
M5598_RS04025	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M5598_RS04030	COG0457	Tetratricopeptide repeat
M5598_RS04030	COG3118	belongs to the thioredoxin family
M5598_RS04035	COG3118	belongs to the thioredoxin family
M5598_RS04040	COG0300	oxidoreductase activity
M5598_RS04045	COG1090	epimerase
M5598_RS04075	COG0622	Phosphoesterase
M5598_RS04095	COG3710	Transcriptional regulator
M5598_RS04100	COG0326	Molecular chaperone. Has ATPase activity
M5598_RS04105	COG0563	adenylate kinase activity
M5598_RS04110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M5598_RS04115	COG3104	oligopeptide transport
M5598_RS04120	COG0250	Participates in transcription elongation, termination and antitermination
M5598_RS04125	COG0367	asparagine synthase
M5598_RS04130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5598_RS04130	COG4651	solute:proton antiporter activity
M5598_RS04135	COG1846	Transcriptional regulator
M5598_RS04135	COG1940	carbohydrate kinase activity
M5598_RS04140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M5598_RS04145	COG1263	PTS System
M5598_RS04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_RS04150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5598_RS04155	COG0735	belongs to the Fur family
M5598_RS04175	COG0596	Alpha beta hydrolase
M5598_RS04180	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M5598_RS04185	COG0033	Phosphoglucomutase
M5598_RS04195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5598_RS04210	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M5598_RS04215	COG1053	succinate dehydrogenase
M5598_RS04220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5598_RS04225	COG0567	Dehydrogenase, E1 component
M5598_RS04230	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5598_RS04235	COG0045	succinate-CoA ligase (ADP-forming) activity
M5598_RS04250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5598_RS04255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M5598_RS04260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M5598_RS04265	COG2233	PERMEase
M5598_RS04285	COG1393	Belongs to the ArsC family
M5598_RS04290	COG4783	chaperone-mediated protein folding
M5598_RS04305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5598_RS04310	COG2716	regulation of RNA biosynthetic process
M5598_RS04315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5598_RS04320	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M5598_RS04335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5598_RS04340	COG1393	Belongs to the ArsC family
M5598_RS04365	COG2837	iron assimilation
M5598_RS04370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS04375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS04380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS04385	COG1334	flagellar protein FlaG
M5598_RS04390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M5598_RS04400	COG1516	flagellar protein fliS
M5598_RS04420	COG1677	Flagellar hook-basal body complex protein FliE
M5598_RS04430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5598_RS04480	COG1987	bacterial-type flagellum assembly
M5598_RS04485	COG1684	flagellar biosynthetic protein fliR
M5598_RS04520	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M5598_RS04525	COG0784	Response regulator, receiver
M5598_RS04525	COG0643	Histidine kinase
M5598_RS04525	COG2198	Histidine kinase
M5598_RS04530	COG2201	protein-glutamate methylesterase activity
M5598_RS04535	COG1192	Involved in chromosome partitioning
M5598_RS04545	COG0835	chemotaxis
M5598_RS04555	COG4133	protoheme IX ABC transporter activity
M5598_RS04560	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5598_RS04565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5598_RS04570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5598_RS04575	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M5598_RS04580	COG1138	Cytochrome C-type biogenesis protein
M5598_RS04585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5598_RS04600	COG2853	Lipoprotein
M5598_RS04610	COG2067	long-chain fatty acid transport protein
M5598_RS04625	COG0183	Belongs to the thiolase family
M5598_RS04630	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5598_RS04630	COG1024	Enoyl-CoA hydratase
M5598_RS04645	COG2062	phosphohistidine phosphatase, SixA
M5598_RS04650	COG2840	Smr protein MutS2
M5598_RS04655	COG2890	protein-(glutamine-N5) methyltransferase activity
M5598_RS04660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M5598_RS04665	COG2860	membrane
M5598_RS04670	COG3101	peptidyl-lysine hydroxylation
M5598_RS04680	COG0431	NADPH-dependent FMN reductase
M5598_RS04685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5598_RS04685	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M5598_RS04690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5598_RS04695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5598_RS04700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M5598_RS04710	COG0101	tRNA pseudouridine synthase activity
M5598_RS04715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5598_RS04720	COG0285	dihydrofolate synthase activity
M5598_RS04725	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M5598_RS04730	COG1286	toxin biosynthetic process
M5598_RS04735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M5598_RS04740	COG0583	DNA-binding transcription factor activity
M5598_RS04745	COG0745	RESPONSE REGULATOR receiver
M5598_RS04755	COG2832	Protein of unknown function (DUF454)
M5598_RS04760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5598_RS04770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M5598_RS04775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M5598_RS04780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5598_RS04785	COG0814	amino acid
M5598_RS04790	COG0251	oxidation-reduction process
M5598_RS04795	COG3681	Belongs to the UPF0597 family
M5598_RS04810	COG2261	transglycosylase associated protein
M5598_RS04815	COG2983	Belongs to the UPF0260 family
M5598_RS04820	COG0668	transmembrane transport
M5598_RS04825	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5598_RS04830	COG0346	lactoylglutathione lyase activity
M5598_RS04840	COG1785	Belongs to the alkaline phosphatase family
M5598_RS04855	COG2226	methyltransferase
M5598_RS04870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5598_RS04875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_RS04885	COG3139	Protein of unknown function (DUF1315)
M5598_RS04890	COG0252	asparaginase activity
M5598_RS04895	COG0616	signal peptide processing
M5598_RS04900	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5598_RS04900	COG1902	pentaerythritol trinitrate reductase activity
M5598_RS04905	COG0778	Nitroreductase
M5598_RS04910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5598_RS04925	COG0123	including yeast histone deacetylase and acetoin utilization protein
M5598_RS04935	COG3083	sulfuric ester hydrolase activity
M5598_RS04940	COG3082	Protein of unknown function (DUF1414)
M5598_RS04945	COG3081	Nucleoid-associated protein
M5598_RS04960	COG1757	Na H antiporter
M5598_RS04965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M5598_RS04970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5598_RS04975	COG2095	MarC family integral membrane protein
M5598_RS04980	COG1012	belongs to the aldehyde dehydrogenase family
M5598_RS04980	COG1454	alcohol dehydrogenase
M5598_RS05000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M5598_RS05010	COG2056	Na+-H+ antiporter family
M5598_RS05015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5598_RS05020	COG2885	chlorophyll binding
M5598_RS05030	COG0346	lactoylglutathione lyase activity
M5598_RS05035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M5598_RS05040	COG4660	Part of a membrane complex involved in electron transport
M5598_RS05045	COG4659	FMN binding
M5598_RS05050	COG4658	electron transport chain
M5598_RS05055	COG4656	Part of a membrane complex involved in electron transport
M5598_RS05060	COG2878	Part of a membrane complex involved in electron transport
M5598_RS05065	COG4657	Part of a membrane complex involved in electron transport
M5598_RS05080	COG0708	Exodeoxyribonuclease III
M5598_RS05090	COG3923	Primosomal replication protein n
M5598_RS05095	COG0730	response to heat
M5598_RS05100	COG1199	ATP-dependent helicase activity
M5598_RS05105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M5598_RS05110	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M5598_RS05115	COG1187	pseudouridine synthase activity
M5598_RS05125	COG1278	Cold shock
M5598_RS05130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M5598_RS05135	COG0542	response to heat
M5598_RS05145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M5598_RS05150	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M5598_RS05155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M5598_RS05165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M5598_RS05175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5598_RS05180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M5598_RS05185	COG0297	glycogen (starch) synthase activity
M5598_RS05205	COG3070	regulator of competence-specific genes
M5598_RS05210	COG1609	Transcriptional regulator
M5598_RS05215	COG3381	protein complex oligomerization
M5598_RS05220	COG0745	RESPONSE REGULATOR receiver
M5598_RS05225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M5598_RS05230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5598_RS05235	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M5598_RS05240	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M5598_RS05245	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M5598_RS05265	COG4067	protein conserved in archaea
M5598_RS05265	COG0189	ligase activity
M5598_RS05270	COG0500	methyltransferase
M5598_RS05275	COG4106	trans-aconitate 2-methyltransferase activity
M5598_RS05280	COG1801	Protein of unknown function DUF72
M5598_RS05285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M5598_RS05290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M5598_RS05295	COG0840	transmembrane signaling receptor activity
M5598_RS05300	COG0632	four-way junction helicase activity
M5598_RS05305	COG2255	four-way junction helicase activity
M5598_RS05310	COG1271	oxidase subunit
M5598_RS05315	COG1294	oxidase, subunit
M5598_RS05320	COG4890	Cyd operon protein YbgT
M5598_RS05330	COG0824	Thioesterase
M5598_RS05335	COG0811	peptide transport
M5598_RS05350	COG0823	Involved in the tonB-independent uptake of proteins
M5598_RS05355	COG2885	chlorophyll binding
M5598_RS05360	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M5598_RS05365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5598_RS05370	COG3012	SEC-C Motif Domain Protein
M5598_RS05370	COG3318	Belongs to the UPF0149 family
M5598_RS05375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M5598_RS05380	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5598_RS05385	COG2186	Transcriptional regulator
M5598_RS05395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5598_RS05395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5598_RS05400	COG0489	protein tyrosine kinase activity
M5598_RS05405	COG0572	uridine kinase
M5598_RS05415	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M5598_RS05420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5598_RS05425	COG0659	secondary active sulfate transmembrane transporter activity
M5598_RS05430	COG1530	ribonuclease E activity
M5598_RS05435	COG0564	pseudouridine synthase activity
M5598_RS05440	COG0424	maF-like protein
M5598_RS05445	COG1399	metal-binding, possibly nucleic acid-binding protein
M5598_RS05455	COG0416	fatty acid biosynthetic process
M5598_RS05460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5598_RS05490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5598_RS05495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M5598_RS05505	COG0084	hydrolase, TatD family'
M5598_RS05510	COG1263	PTS System
M5598_RS05510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_RS05525	COG0733	neurotransmitter:sodium symporter activity
M5598_RS05540	COG4667	esterase of the alpha-beta hydrolase superfamily
M5598_RS05545	COG0469	pyruvate kinase activity
M5598_RS05550	COG1940	carbohydrate kinase activity
M5598_RS05555	COG0784	Response regulator, receiver
M5598_RS05555	COG0835	chemotaxis
M5598_RS05560	COG0587	DNA-directed DNA polymerase activity
M5598_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_RS05580	COG0616	signal peptide processing
M5598_RS05585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M5598_RS05590	COG0539	negative regulation of cytoplasmic translation
M5598_RS05600	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M5598_RS05605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M5598_RS05610	COG0284	orotidine-5'-phosphate decarboxylase activity
M5598_RS05615	COG4166	transmembrane transport
M5598_RS05640	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M5598_RS05650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M5598_RS05650	COG3008	intermembrane lipid transfer
M5598_RS05655	COG2995	paraquat-inducible protein a
M5598_RS05660	COG3258	Cytochrome c
M5598_RS05665	COG2863	cytochrome
M5598_RS05705	COG4232	protein-disulfide reductase activity
M5598_RS05710	COG3118	belongs to the thioredoxin family
M5598_RS05730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS05740	COG1136	(ABC) transporter
M5598_RS05740	COG0577	efflux transmembrane transporter activity
M5598_RS05745	COG1136	(ABC) transporter
M5598_RS05745	COG0577	efflux transmembrane transporter activity
M5598_RS05750	COG1136	(ABC) transporter
M5598_RS05750	COG0577	efflux transmembrane transporter activity
M5598_RS05755	COG1335	isochorismatase
M5598_RS05775	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M5598_RS05800	COG2116	formate transmembrane transporter activity
M5598_RS05810	COG0390	transport system, permease component
M5598_RS05815	COG4459	periplasmic nitrate reductase
M5598_RS05820	COG3005	denitrification pathway
M5598_RS05825	COG0243	molybdopterin cofactor binding
M5598_RS05840	COG1227	inorganic diphosphatase activity
M5598_RS05850	COG4172	Belongs to the ABC transporter superfamily
M5598_RS05860	COG4171	peptide transport system, permease
M5598_RS05875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M5598_RS05880	COG1842	Phage shock protein A
M5598_RS05890	COG1983	PspC domain protein
M5598_RS05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS05910	COG2818	Glycosylase
M5598_RS05915	COG5380	lipid catabolic process
M5598_RS05920	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5598_RS05925	COG0626	cystathionine gamma-synthase activity
M5598_RS05935	COG0733	neurotransmitter:sodium symporter activity
M5598_RS05945	COG0564	pseudouridine synthase activity
M5598_RS05955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5598_RS05960	COG1151	hydroxylamine reductase activity
M5598_RS05965	COG3604	Transcriptional regulator
M5598_RS05975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5598_RS05980	COG4136	ATPase activity
M5598_RS05985	COG4135	transport system, permease component
M5598_RS05990	COG4134	Bacterial extracellular solute-binding protein
M5598_RS05995	COG0398	Pfam SNARE associated Golgi protein
M5598_RS06005	COG0493	'glutamate synthase
M5598_RS06030	COG3313	Fe-S protein
M5598_RS06060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M5598_RS06080	COG1061	Type III restriction enzyme res subunit
M5598_RS06085	COG1187	pseudouridine synthase activity
M5598_RS06090	COG2814	Major facilitator Superfamily
M5598_RS06120	COG3005	denitrification pathway
M5598_RS06125	COG0702	epimerase
M5598_RS06130	COG0534	Mate efflux family protein
M5598_RS06135	COG4181	ATPase activity
M5598_RS06150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5598_RS06165	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M5598_RS06170	COG3273	potassium ion transport
M5598_RS06170	COG2985	domain, Protein
M5598_RS06175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5598_RS06185	COG1737	Transcriptional regulator
M5598_RS06190	COG0076	glutamate decarboxylase activity
M5598_RS06200	COG2431	L-lysine efflux transmembrane transporter activity
M5598_RS06210	COG3070	regulator of competence-specific genes
M5598_RS06225	COG4191	Histidine kinase
M5598_RS06225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_RS06235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M5598_RS06240	COG3048	D-serine ammonia-lyase activity
M5598_RS06245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M5598_RS06250	COG4988	ABC transporter
M5598_RS06255	COG0492	ferredoxin-NADP+ reductase activity
M5598_RS06280	COG0471	metal ion transport
M5598_RS06285	COG2949	membrane
M5598_RS06290	COG0281	malic enzyme
M5598_RS06295	COG1643	Atp-dependent helicase
M5598_RS06300	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M5598_RS06315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5598_RS06350	COG0277	FAD linked oxidase domain protein
M5598_RS06350	COG0247	lactate metabolic process
M5598_RS06365	COG2986	histidine ammonia-lyase
M5598_RS06370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M5598_RS06375	COG0010	Belongs to the arginase family
M5598_RS06380	COG1228	amidohydrolase
M5598_RS06385	COG2188	Transcriptional regulator
M5598_RS06400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5598_RS06410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M5598_RS06420	COG0393	Putative heavy-metal-binding
M5598_RS06450	COG3706	GGDEF domain
M5598_RS06455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M5598_RS06460	COG0072	phenylalanine-tRNA ligase activity
M5598_RS06460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5598_RS06470	COG0776	regulation of translation
M5598_RS06480	COG0500	methyltransferase
M5598_RS06485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M5598_RS06490	COG0295	cytidine deaminase activity
M5598_RS06495	COG1346	cytolysis
M5598_RS06500	COG1380	Effector of murein hydrolase LrgA
M5598_RS06505	COG2925	Exonuclease
M5598_RS06510	COG1823	symporter activity
M5598_RS06515	COG0702	epimerase
M5598_RS06520	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M5598_RS06525	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M5598_RS06535	COG2062	phosphohistidine phosphatase, SixA
M5598_RS06545	COG2988	succinylglutamate desuccinylase activity
M5598_RS06550	COG4139	cobalamin transport
M5598_RS06555	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M5598_RS06575	COG0583	DNA-binding transcription factor activity
M5598_RS06595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M5598_RS06600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5598_RS06605	COG3475	LICD family
M5598_RS06610	COG1451	nucleotide metabolic process
M5598_RS06615	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M5598_RS06645	COG3938	Belongs to the proline racemase family
M5598_RS06660	COG2423	ornithine cyclodeaminase activity
M5598_RS06665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5598_RS06670	COG3842	ATPase activity
M5598_RS06675	COG1176	ABC-type spermidine putrescine transport system, permease component I
M5598_RS06680	COG1177	transmembrane transport
M5598_RS06690	COG3291	Pkd domain containing protein
M5598_RS06705	COG0444	Belongs to the ABC transporter superfamily
M5598_RS06710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5598_RS06715	COG0601	transmembrane transport
M5598_RS06725	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5598_RS06735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M5598_RS06745	COG0625	glutathione transferase activity
M5598_RS06785	COG1280	lysine exporter protein (LysE YggA)
M5598_RS06790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5598_RS06810	COG1757	Na H antiporter
M5598_RS06815	COG0174	glutamine synthetase
M5598_RS06820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M5598_RS06825	COG1917	Cupin 2, conserved barrel domain protein
M5598_RS06825	COG1396	sequence-specific DNA binding
M5598_RS06830	COG1012	belongs to the aldehyde dehydrogenase family
M5598_RS06835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5598_RS06845	COG2957	Belongs to the agmatine deiminase family
M5598_RS06850	COG1012	belongs to the aldehyde dehydrogenase family
M5598_RS06855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5598_RS06860	COG1227	inorganic diphosphatase activity
M5598_RS06865	COG2771	luxR family
M5598_RS06865	COG2200	EAL domain
M5598_RS06880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS06885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_RS06920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M5598_RS06935	COG1846	Transcriptional regulator
M5598_RS06940	COG2315	Protein conserved in bacteria
M5598_RS06960	COG0110	maltose O-acetyltransferase activity
M5598_RS06990	COG3063	Type IV pilus biogenesis stability protein PilW
M5598_RS06995	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M5598_RS07005	COG0531	amino acid
M5598_RS07010	COG1560	Kdo2-lipid A biosynthetic process
M5598_RS07015	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M5598_RS07020	COG1280	lysine exporter protein (LysE YggA)
M5598_RS07030	COG1115	amino acid carrier protein
M5598_RS07055	COG1368	sulfuric ester hydrolase activity
M5598_RS07060	COG0642	Histidine kinase
M5598_RS07065	COG0745	RESPONSE REGULATOR receiver
M5598_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_RS07095	COG2113	Glycine betaine
M5598_RS07100	COG4176	ABC-type proline glycine betaine transport system permease component
M5598_RS07120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5598_RS07125	COG0456	acetyltransferase
M5598_RS07130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5598_RS07135	COG0662	Cupin 2, conserved barrel domain protein
M5598_RS07140	COG0527	aspartate kinase activity
M5598_RS07160	COG1858	cytochrome C peroxidase
M5598_RS07175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS07190	COG3290	protein histidine kinase activity
M5598_RS07195	COG4565	transcriptional regulatory protein
M5598_RS07200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M5598_RS07205	COG0363	glucosamine-6-phosphate deaminase activity
M5598_RS07210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M5598_RS07230	COG3284	Transcriptional regulator
M5598_RS07235	COG1012	belongs to the aldehyde dehydrogenase family
M5598_RS07305	COG4669	(LipO)protein
M5598_RS07325	COG3177	Filamentation induced by cAMP protein fic
M5598_RS07350	COG4792	protein secretion
M5598_RS07355	COG4791	protein targeting
M5598_RS07360	COG4794	Type iii secretion
M5598_RS07365	COG4790	Type iii secretion
M5598_RS07435	COG0457	Tetratricopeptide repeat
M5598_RS07455	COG0730	response to heat
M5598_RS07485	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M5598_RS07490	COG0372	Belongs to the citrate synthase family
M5598_RS07500	COG2828	Protein conserved in bacteria
M5598_RS07525	COG0561	phosphatase activity
M5598_RS07530	COG0602	queuosine metabolic process
M5598_RS07535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M5598_RS07540	COG3706	GGDEF domain
M5598_RS07585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5598_RS07590	COG0840	transmembrane signaling receptor activity
M5598_RS07595	COG1254	Belongs to the acylphosphatase family
M5598_RS07600	COG2920	part of a sulfur-relay system
M5598_RS07610	COG0670	Belongs to the BI1 family
M5598_RS07615	COG1126	abc transporter atp-binding protein
M5598_RS07620	COG0765	amino acid transport
M5598_RS07625	COG4597	amino acid ABC transporter
M5598_RS07630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_RS07640	COG1666	GTP binding
M5598_RS07645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M5598_RS07665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5598_RS07665	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M5598_RS07670	COG3008	intermembrane lipid transfer
M5598_RS07675	COG2995	paraquat-inducible protein a
M5598_RS07680	COG1132	(ABC) transporter
M5598_RS07685	COG1956	GAF domain-containing protein
M5598_RS07690	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M5598_RS07705	COG0308	aminopeptidase N
M5598_RS07715	COG2902	Dehydrogenase
M5598_RS07720	COG0167	dihydroorotate dehydrogenase activity
M5598_RS07730	COG0116	Belongs to the methyltransferase superfamily
M5598_RS07730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5598_RS07740	COG0488	(ABC) transporter
M5598_RS07755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5598_RS07760	COG1067	ATP-dependent peptidase activity
M5598_RS07765	COG3120	sequence-specific DNA binding
M5598_RS07785	COG0784	Response regulator, receiver
M5598_RS07785	COG2205	protein histidine kinase activity
M5598_RS07800	COG3278	Belongs to the heme-copper respiratory oxidase family
M5598_RS07815	COG2010	Cytochrome c
M5598_RS07825	COG2217	Heavy metal translocating P-type atpase
M5598_RS07840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5598_RS07845	COG0589	response to stress
M5598_RS07850	COG0037	tRNA processing
M5598_RS07870	COG3842	ATPase activity
M5598_RS07880	COG1177	transmembrane transport
M5598_RS07890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M5598_RS07895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5598_RS07905	COG0004	ammonium transporteR
M5598_RS07960	COG0437	4 iron, 4 sulfur cluster binding
M5598_RS07965	COG0243	molybdopterin cofactor binding
M5598_RS07965	COG3383	formate dehydrogenase (NAD+) activity
M5598_RS07975	COG3381	protein complex oligomerization
M5598_RS07995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M5598_RS08000	COG0488	(ABC) transporter
M5598_RS08005	COG4191	Histidine kinase
M5598_RS08010	COG2204	response regulator
M5598_RS08025	COG3842	ATPase activity
M5598_RS08030	COG0746	molybdenum cofactor guanylyltransferase activity
M5598_RS08035	COG0303	'Molybdopterin
M5598_RS08045	COG0438	transferase activity, transferring glycosyl groups
M5598_RS08050	COG1215	transferase activity, transferring glycosyl groups
M5598_RS08055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5598_RS08065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5598_RS08080	COG1643	Atp-dependent helicase
M5598_RS08085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5598_RS08100	COG3302	dmso reductase anchor subunit
M5598_RS08105	COG0437	4 iron, 4 sulfur cluster binding
M5598_RS08110	COG0243	molybdopterin cofactor binding
M5598_RS08140	COG3706	GGDEF domain
M5598_RS08150	COG0443	Heat shock 70 kDa protein
M5598_RS08155	COG0443	Heat shock 70 kDa protein
M5598_RS08180	COG1132	(ABC) transporter
M5598_RS08185	COG1132	(ABC) transporter
M5598_RS08205	COG0814	amino acid
M5598_RS08210	COG1454	alcohol dehydrogenase
M5598_RS08215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M5598_RS08225	COG0861	Integral membrane protein TerC family
M5598_RS08235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M5598_RS08240	COG1328	CTP reductase activity
M5598_RS08245	COG1280	lysine exporter protein (LysE YggA)
M5598_RS08255	COG5001	Diguanylate cyclase
M5598_RS08255	COG3300	MHYT domain
M5598_RS08265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_RS08265	COG4191	Histidine kinase
M5598_RS08270	COG0471	metal ion transport
M5598_RS08300	COG1940	carbohydrate kinase activity
M5598_RS08305	COG3148	PFAM DTW domain containing protein
M5598_RS08340	COG0840	transmembrane signaling receptor activity
M5598_RS08340	COG3290	protein histidine kinase activity
M5598_RS08345	COG0791	NLP P60 protein
M5598_RS08355	COG3706	GGDEF domain
M5598_RS08360	COG2201	protein-glutamate methylesterase activity
M5598_RS08365	COG3001	Fructosamine kinase
M5598_RS08375	COG0307	riboflavin synthase, alpha
M5598_RS08380	COG0534	Mate efflux family protein
M5598_RS08390	COG1793	dna ligase
M5598_RS08420	COG2204	response regulator
M5598_RS08430	COG0438	transferase activity, transferring glycosyl groups
M5598_RS08475	COG0006	proline dipeptidase activity
M5598_RS08485	COG0583	DNA-binding transcription factor activity
M5598_RS08500	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M5598_RS08510	COG2985	domain, Protein
M5598_RS08535	COG2272	Belongs to the type-B carboxylesterase lipase family
M5598_RS08540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5598_RS08545	COG0729	surface antigen
M5598_RS08645	COG0371	Dehydrogenase
M5598_RS08665	COG2188	Transcriptional regulator
M5598_RS08670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS08670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS08670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS08675	COG0383	alpha-mannosidase activity
M5598_RS08680	COG1929	Belongs to the glycerate kinase type-1 family
M5598_RS08685	COG1482	cell wall glycoprotein biosynthetic process
M5598_RS08690	COG1609	Transcriptional regulator
M5598_RS08695	COG2211	Major facilitator Superfamily
M5598_RS08705	COG4580	involved in the transport of maltose and maltodextrins
M5598_RS08715	COG3250	beta-galactosidase activity
M5598_RS08720	COG1609	Transcriptional regulator
M5598_RS08725	COG1609	Transcriptional regulator
M5598_RS08730	COG2017	converts alpha-aldose to the beta-anomer
M5598_RS08785	COG3153	acetyltransferase
M5598_RS08855	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5598_RS09015	COG1683	Conserved Protein
M5598_RS09235	COG1280	lysine exporter protein (LysE YggA)
M5598_RS09605	COG0346	lactoylglutathione lyase activity
M5598_RS09725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5598_RS09735	COG3768	UPF0283 membrane protein
M5598_RS09740	COG3106	COG3106 Predicted ATPase
M5598_RS09755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5598_RS09760	COG2205	protein histidine kinase activity
M5598_RS09760	COG0784	Response regulator, receiver
M5598_RS09770	COG0494	nUDIX hydrolase
M5598_RS09775	COG0814	amino acid
M5598_RS09780	COG1760	l-serine dehydratase
M5598_RS09785	COG2200	EAL domain
M5598_RS09795	COG0720	synthase
M5598_RS09805	COG1278	Cold shock
M5598_RS09810	COG0557	exoribonuclease II activity
M5598_RS09835	COG0017	Asparaginyl-tRNA synthetase
M5598_RS09845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_RS09860	COG1448	Aminotransferase
M5598_RS09880	COG0840	transmembrane signaling receptor activity
M5598_RS09885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5598_RS09890	COG1846	Transcriptional regulator
M5598_RS09915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M5598_RS09930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5598_RS09935	COG3108	Peptidase M15
M5598_RS09940	COG2989	Protein conserved in bacteria
M5598_RS09965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5598_RS09975	COG3088	subunit of a heme lyase
M5598_RS09975	COG4235	cytochrome complex assembly
M5598_RS09985	COG1138	Cytochrome C-type biogenesis protein
M5598_RS09990	COG3301	Polysulphide reductase, NrfD
M5598_RS09995	COG0437	4 iron, 4 sulfur cluster binding
M5598_RS10005	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M5598_RS10025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5598_RS10030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5598_RS10035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5598_RS10060	COG0019	diaminopimelate decarboxylase activity
M5598_RS10100	COG0322	excinuclease ABC activity
M5598_RS10105	COG2197	response regulator
M5598_RS10110	COG0417	DNA replication proofreading
M5598_RS10120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5598_RS10125	COG3099	Belongs to the UPF0263 family
M5598_RS10130	COG1187	pseudouridine synthase activity
M5598_RS10140	COG0009	L-threonylcarbamoyladenylate synthase
M5598_RS10145	COG0613	PHP domain protein
M5598_RS10155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5598_RS10160	COG0512	Glutamine amidotransferase of anthranilate synthase
M5598_RS10165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M5598_RS10170	COG0134	indole-3-glycerol-phosphate synthase activity
M5598_RS10170	COG0135	phosphoribosylanthranilate isomerase activity
M5598_RS10175	COG0133	tryptophan synthase activity
M5598_RS10180	COG0159	tryptophan synthase activity
M5598_RS10185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5598_RS10190	COG0318	PFAM AMP-dependent synthetase and ligase
M5598_RS10195	COG1301	dicarboxylic acid transport
M5598_RS10215	COG2917	probably involved in intracellular septation
M5598_RS10225	COG2350	Protein conserved in bacteria
M5598_RS10235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5598_RS10240	COG0583	DNA-binding transcription factor activity
M5598_RS10255	COG2199	diguanylate cyclase activity
M5598_RS10255	COG2203	Gaf domain
M5598_RS10255	COG2200	EAL domain
M5598_RS10260	COG1032	radical SAM domain protein
M5598_RS10265	COG0840	transmembrane signaling receptor activity
M5598_RS10270	COG0745	RESPONSE REGULATOR receiver
M5598_RS10275	COG3850	Histidine kinase
M5598_RS10275	COG5002	protein histidine kinase activity
M5598_RS10320	COG1435	thymidine kinase activity
M5598_RS10325	COG0215	cysteine-tRNA ligase activity
M5598_RS10330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5598_RS10335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5598_RS10340	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5598_RS10345	COG3012	SEC-C Motif Domain Protein
M5598_RS10350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M5598_RS10350	COG0140	phosphoribosyl-ATP diphosphatase activity
M5598_RS10355	COG0107	imidazoleglycerol-phosphate synthase activity
M5598_RS10360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M5598_RS10365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M5598_RS10370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M5598_RS10370	COG0131	Imidazoleglycerol-phosphate dehydratase
M5598_RS10375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M5598_RS10380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5598_RS10385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M5598_RS10400	COG1757	Na H antiporter
M5598_RS10410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_RS10420	COG0482	sulfurtransferase activity
M5598_RS10425	COG2915	High frequency lysogenization protein hflD homolog
M5598_RS10430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5598_RS10450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M5598_RS10465	COG0300	oxidoreductase activity
M5598_RS10475	COG0501	Belongs to the peptidase M48B family
M5598_RS10485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M5598_RS10495	COG0156	8-amino-7-oxononanoate synthase activity
M5598_RS10500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M5598_RS10505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5598_RS10510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5598_RS10525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M5598_RS10530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M5598_RS10535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M5598_RS10540	COG1674	ftsk spoiiie
M5598_RS10550	COG0686	Belongs to the AlaDH PNT family
M5598_RS10560	COG0583	DNA-binding transcription factor activity
M5598_RS10575	COG3568	Endonuclease Exonuclease Phosphatase
M5598_RS10600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_RS10605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS10610	COG0840	transmembrane signaling receptor activity
M5598_RS10625	COG5002	protein histidine kinase activity
M5598_RS10625	COG0784	Response regulator, receiver
M5598_RS10635	COG0754	glutathionylspermidine amidase activity
M5598_RS10645	COG3766	membrane
M5598_RS10655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M5598_RS10665	COG0366	Alpha amylase catalytic
M5598_RS10670	COG1122	ATPase activity
M5598_RS10675	COG4120	Belongs to the binding-protein-dependent transport system permease family
M5598_RS10685	COG3092	negative regulation of chromosome organization
M5598_RS10690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5598_RS10695	COG0280	phosphate acetyltransferase
M5598_RS10695	COG0857	belongs to the CobB CobQ family
M5598_RS10700	COG3174	membrane
M5598_RS10710	COG0435	Glutathione S-transferase
M5598_RS10720	COG0444	Belongs to the ABC transporter superfamily
M5598_RS10725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5598_RS10730	COG0601	transmembrane transport
M5598_RS10740	COG0314	molybdopterin synthase activity
M5598_RS10745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M5598_RS10750	COG0315	cyclic pyranopterin monophosphate synthase activity
M5598_RS10755	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5598_RS10760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5598_RS10765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M5598_RS10770	COG2198	Histidine kinase
M5598_RS10775	COG2204	response regulator
M5598_RS10780	COG0556	nucleotide-excision repair
M5598_RS10825	COG1882	Formate acetyltransferase
M5598_RS10835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M5598_RS10845	COG3013	Belongs to the UPF0304 family
M5598_RS10850	COG2766	serine protein kinase
M5598_RS10855	COG2718	Belongs to the UPF0229 family
M5598_RS10860	COG2719	SpoVR family
M5598_RS10865	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M5598_RS10875	COG1663	tetraacyldisaccharide 4'-kinase activity
M5598_RS10880	COG1132	(ABC) transporter
M5598_RS10885	COG2333	competence protein COMEC
M5598_RS10885	COG0658	competence protein
M5598_RS10895	COG4591	ABC-type transport system involved in lipoprotein release permease component
M5598_RS10900	COG1136	(ABC) transporter
M5598_RS10905	COG4591	ABC-type transport system involved in lipoprotein release permease component
M5598_RS10915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5598_RS10935	COG1252	NADH dehydrogenase
M5598_RS10940	COG3150	esterase
M5598_RS10965	COG0537	adenosine 5'-monophosphoramidase activity
M5598_RS10990	COG0517	IMP dehydrogenase activity
M5598_RS10990	COG0516	GMP reductase activity
M5598_RS10995	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M5598_RS11000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M5598_RS11005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5598_RS11015	COG2199	diguanylate cyclase activity
M5598_RS11030	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M5598_RS11035	COG1946	Acyl-CoA thioesterase
M5598_RS11045	COG1522	sequence-specific DNA binding
M5598_RS11070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_RS11120	COG0477	Major facilitator Superfamily
M5598_RS11125	COG2855	membrane
M5598_RS11145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5598_RS11150	COG0596	Alpha beta hydrolase
M5598_RS11155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M5598_RS11160	COG1169	isochorismate synthase
M5598_RS11165	COG0436	Aminotransferase
M5598_RS11170	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M5598_RS11175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M5598_RS11190	COG1555	photosystem II stabilization
M5598_RS11195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5598_RS11200	COG0776	regulation of translation
M5598_RS11205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M5598_RS11210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M5598_RS11220	COG0544	peptidyl-prolyl cis-trans isomerase activity
M5598_RS11235	COG2204	response regulator
M5598_RS11245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M5598_RS11250	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M5598_RS11255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M5598_RS11260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M5598_RS11275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5598_RS11280	COG0569	domain protein
M5598_RS11285	COG0513	Belongs to the DEAD box helicase family
M5598_RS11290	COG1253	flavin adenine dinucleotide binding
M5598_RS11325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5598_RS11330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5598_RS11345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5598_RS11350	COG1216	Glycosyl transferase, family 2
M5598_RS11355	COG2986	histidine ammonia-lyase
M5598_RS11380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5598_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_RS11410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M5598_RS11415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5598_RS11420	COG0583	DNA-binding transcription factor activity
M5598_RS11425	COG2951	lytic endotransglycosylase activity
M5598_RS11430	COG3100	YcgL domain-containing protein
M5598_RS11435	COG0850	regulation of cytokinetic process
M5598_RS11440	COG2894	cell division
M5598_RS11445	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M5598_RS11450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M5598_RS11455	COG0318	PFAM AMP-dependent synthetase and ligase
M5598_RS11460	COG2267	carboxylic ester hydrolase activity
M5598_RS11475	COG1214	PFAM Peptidase M22, glycoprotease
M5598_RS11480	COG1199	ATP-dependent helicase activity
M5598_RS11485	COG0788	formyltetrahydrofolate deformylase activity
M5598_RS11490	COG3102	Protein conserved in bacteria
M5598_RS11495	COG0018	arginyl-trna synthetase
M5598_RS11515	COG1918	ferrous iron import across plasma membrane
M5598_RS11520	COG4977	sequence-specific DNA binding
M5598_RS11525	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M5598_RS11530	COG1121	(ABC) transporter
M5598_RS11535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5598_RS11540	COG0121	glutamine amidotransferase
M5598_RS11545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M5598_RS11550	COG1960	acyl-CoA dehydrogenase activity
M5598_RS11565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5598_RS11570	COG0328	RNA-DNA hybrid ribonuclease activity
M5598_RS11575	COG2226	methyltransferase
M5598_RS11580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5598_RS11585	COG1388	LysM domain
M5598_RS11585	COG0741	lytic transglycosylase activity
M5598_RS11595	COG3021	interspecies interaction between organisms
M5598_RS11600	COG0347	Belongs to the P(II) protein family
M5598_RS11610	COG0037	tRNA processing
M5598_RS11615	COG0825	malonyl-CoA metabolic process
M5598_RS11620	COG0587	DNA-directed DNA polymerase activity
M5598_RS11625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5598_RS11630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5598_RS11635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5598_RS11640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5598_RS11645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5598_RS11650	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M5598_RS11660	COG0750	zinc metalloprotease
M5598_RS11665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M5598_RS11670	COG0575	Belongs to the CDS family
M5598_RS11675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5598_RS11680	COG0233	cytoplasmic translational termination
M5598_RS11685	COG0528	UMP kinase activity
M5598_RS11690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M5598_RS11695	COG0052	Belongs to the universal ribosomal protein uS2 family
M5598_RS11700	COG0024	Methionine aminopeptidase
M5598_RS11705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M5598_RS11715	COG0564	pseudouridine synthase activity
M5598_RS11720	COG3098	single-species biofilm formation
M5598_RS11745	COG1671	Belongs to the UPF0178 family
M5598_RS11750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M5598_RS11760	COG0254	rRNA binding
M5598_RS11765	COG1720	tRNA m6t6A37 methyltransferase activity
M5598_RS11770	COG0442	prolyl-tRNA aminoacylation
M5598_RS11790	COG0733	neurotransmitter:sodium symporter activity
M5598_RS11805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5598_RS11810	COG0514	ATP-dependent DNA helicase (RecQ)
M5598_RS11815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5598_RS11830	COG1477	protein flavinylation
M5598_RS11835	COG2871	sodium ion transport
M5598_RS11840	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M5598_RS11845	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M5598_RS11850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M5598_RS11855	COG1805	sodium ion transport
M5598_RS11860	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M5598_RS11865	COG0271	Belongs to the BolA IbaG family
M5598_RS11870	COG2813	Specifically methylates the guanine in position
M5598_RS11875	COG3056	Lipoprotein
M5598_RS11895	COG1595	DNA-templated transcription, initiation
M5598_RS11915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M5598_RS11920	COG0693	protein deglycase activity
M5598_RS11925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M5598_RS11930	COG3706	GGDEF domain
M5598_RS11940	COG2166	iron-sulfur cluster assembly
M5598_RS11945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5598_RS11950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M5598_RS11960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5598_RS11960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5598_RS11970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5598_RS11975	COG1074	ATP-dependent DNA helicase activity
M5598_RS11980	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M5598_RS12000	COG3141	response to X-ray
M5598_RS12005	COG2171	N-acyltransferase activity
M5598_RS12010	COG0584	glycerophosphoryl diester phosphodiesterase
M5598_RS12015	COG2271	Major facilitator Superfamily
M5598_RS12020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5598_RS12025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5598_RS12030	COG1349	DNA-binding transcription factor activity
M5598_RS12035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M5598_RS12040	COG0598	Magnesium transport protein CorA
M5598_RS12055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5598_RS12060	COG1609	Transcriptional regulator
M5598_RS12065	COG2211	Major facilitator Superfamily
M5598_RS12080	COG2017	converts alpha-aldose to the beta-anomer
M5598_RS12085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M5598_RS12095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5598_RS12100	COG1609	Transcriptional regulator
M5598_RS12105	COG3250	beta-galactosidase activity
M5598_RS12110	COG2731	YhcH YjgK YiaL family protein
M5598_RS12115	COG0531	amino acid
M5598_RS12120	COG0583	DNA-binding transcription factor activity
M5598_RS12180	COG4964	Belongs to the GSP D family
M5598_RS12205	COG2169	Transcriptional regulator
M5598_RS12210	COG1022	Amp-dependent synthetase and ligase
M5598_RS12220	COG0583	DNA-binding transcription factor activity
M5598_RS12225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5598_RS12230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5598_RS12240	COG0560	Phosphoserine phosphatase
M5598_RS12250	COG0813	purine-nucleoside phosphorylase activity
M5598_RS12255	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M5598_RS12260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M5598_RS12265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M5598_RS12270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5598_RS12275	COG0084	hydrolase, TatD family'
M5598_RS12285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M5598_RS12305	COG3153	acetyltransferase
M5598_RS12310	COG3154	lipid carrier protein
M5598_RS12320	COG0826	peptidase U32
M5598_RS12325	COG0826	peptidase U32
M5598_RS12330	COG0534	Mate efflux family protein
M5598_RS12345	COG1185	polyribonucleotide nucleotidyltransferase activity
M5598_RS12350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M5598_RS12355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M5598_RS12360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M5598_RS12365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M5598_RS12370	COG0195	Participates in both transcription termination and antitermination
M5598_RS12375	COG0779	Required for maturation of 30S ribosomal subunits
M5598_RS12390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5598_RS12395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5598_RS12400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M5598_RS12405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5598_RS12410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M5598_RS12415	COG1534	Rna-binding protein
M5598_RS12420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5598_RS12425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M5598_RS12430	COG2027	D-alanyl-D-alanine carboxypeptidase
M5598_RS12450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M5598_RS12480	COG0484	heat shock protein binding
M5598_RS12485	COG0443	Heat shock 70 kDa protein
M5598_RS12495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M5598_RS12500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5598_RS12510	COG0497	DNA recombination
M5598_RS12515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5598_RS12520	COG2914	Belongs to the UPF0125 (RnfH) family
M5598_RS12525	COG2867	negative regulation of translational initiation
M5598_RS12530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M5598_RS12610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M5598_RS12635	COG0583	DNA-binding transcription factor activity
M5598_RS12640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5598_RS12640	COG3153	acetyltransferase
M5598_RS12660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5598_RS12665	COG2873	o-acetylhomoserine
M5598_RS12695	COG1115	amino acid carrier protein
M5598_RS12705	COG1584	GPR1 FUN34 yaaH family protein
M5598_RS12715	COG1757	Na H antiporter
M5598_RS12720	COG0519	Catalyzes the synthesis of GMP from XMP
M5598_RS12720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5598_RS12725	COG0516	GMP reductase activity
M5598_RS12725	COG0517	IMP dehydrogenase activity
M5598_RS12730	COG1570	exodeoxyribonuclease VII activity
M5598_RS12745	COG1160	GTP binding
M5598_RS12750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5598_RS12755	COG2976	Protein conserved in bacteria
M5598_RS12760	COG0124	histidyl-tRNA synthetase
M5598_RS12765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M5598_RS12775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M5598_RS12780	COG0105	UTP biosynthetic process
M5598_RS12785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M5598_RS12790	COG2975	iron-sulfur cluster assembly
M5598_RS12795	COG0633	Ferredoxin
M5598_RS12800	COG0443	Heat shock 70 kDa protein
M5598_RS12805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M5598_RS12815	COG0822	iron-sulfur transferase activity
M5598_RS12820	COG1104	cysteine desulfurase activity
M5598_RS12835	COG0483	inositol monophosphate 1-phosphatase activity
M5598_RS12840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5598_RS12845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5598_RS12850	COG1862	Preprotein translocase
M5598_RS12855	COG0343	queuine tRNA-ribosyltransferase activity
M5598_RS12860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M5598_RS12870	COG0517	IMP dehydrogenase activity
M5598_RS12880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M5598_RS12885	COG0583	DNA-binding transcription factor activity
M5598_RS12890	COG0450	alkyl hydroperoxide reductase
M5598_RS12895	COG3142	Participates in the control of copper homeostasis
M5598_RS12905	COG0704	Plays a role in the regulation of phosphate uptake
M5598_RS12910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5598_RS12915	COG0581	inorganic phosphate transmembrane transporter activity
M5598_RS12925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M5598_RS12930	COG0248	Ppx GppA phosphatase
M5598_RS12940	COG5002	protein histidine kinase activity
M5598_RS12945	COG0745	RESPONSE REGULATOR receiver
M5598_RS12950	COG2974	May be involved in recombination
M5598_RS12955	COG0826	peptidase U32
M5598_RS12960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5598_RS13015	COG0542	response to heat
M5598_RS13020	COG1496	oxidoreductase activity
M5598_RS13025	COG0564	pseudouridine synthase activity
M5598_RS13030	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5598_RS13035	COG0741	lytic transglycosylase activity
M5598_RS13040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5598_RS13045	COG1605	Chorismate mutase
M5598_RS13045	COG0077	Prephenate dehydratase
M5598_RS13050	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M5598_RS13055	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M5598_RS13065	COG0488	(ABC) transporter
M5598_RS13075	COG0739	heme binding
M5598_RS13080	COG1605	Chorismate mutase
M5598_RS13080	COG0287	Prephenate dehydrogenase
M5598_RS13085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M5598_RS13090	COG1472	Belongs to the glycosyl hydrolase 3 family
M5598_RS13095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M5598_RS13100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M5598_RS13115	COG1966	Carbon starvation protein
M5598_RS13120	COG3275	phosphorelay sensor kinase activity
M5598_RS13125	COG3279	Response regulator of the LytR AlgR family
M5598_RS13130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M5598_RS13135	COG1047	Peptidyl-prolyl cis-trans
M5598_RS13140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M5598_RS13145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5598_RS13150	COG0196	riboflavin kinase activity
M5598_RS13155	COG0728	peptidoglycan biosynthetic process
M5598_RS13160	COG0268	Binds directly to 16S ribosomal RNA
M5598_RS13165	COG0640	Transcriptional regulator
M5598_RS13170	COG0583	DNA-binding transcription factor activity
M5598_RS13175	COG1283	sodium-dependent phosphate transmembrane transporter activity
M5598_RS13185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M5598_RS13190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M5598_RS13195	COG0730	response to heat
M5598_RS13205	COG0494	nUDIX hydrolase
M5598_RS13210	COG3066	DNA modification
M5598_RS13220	COG0667	Aldo Keto reductase
M5598_RS13235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M5598_RS13245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5598_RS13250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5598_RS13255	COG4974	Belongs to the 'phage' integrase family
M5598_RS13260	COG0716	FMN binding
M5598_RS13270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M5598_RS13275	COG0513	Belongs to the DEAD box helicase family
M5598_RS13280	COG3022	response to hydroperoxide
M5598_RS13315	COG1115	amino acid carrier protein
M5598_RS13330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M5598_RS13335	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M5598_RS13340	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M5598_RS13345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5598_RS13350	COG0083	homoserine kinase activity
M5598_RS13365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5598_RS13375	COG0745	RESPONSE REGULATOR receiver
M5598_RS13385	COG0784	Response regulator, receiver
M5598_RS13385	COG2198	Histidine kinase
M5598_RS13385	COG5002	protein histidine kinase activity
M5598_RS13390	COG5001	Diguanylate cyclase
M5598_RS13390	COG4251	negative regulation of phosphorylation
M5598_RS13390	COG3706	GGDEF domain
M5598_RS13390	COG2203	Gaf domain
M5598_RS13395	COG1242	4 iron, 4 sulfur cluster binding
M5598_RS13400	COG0067	glutamate synthase
M5598_RS13400	COG0069	glutamate synthase activity
M5598_RS13400	COG0070	glutamate synthase
M5598_RS13410	COG0067	glutamate synthase
M5598_RS13410	COG0069	glutamate synthase activity
M5598_RS13410	COG0070	glutamate synthase
M5598_RS13415	COG0493	'glutamate synthase
M5598_RS13425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5598_RS13435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5598_RS13440	COG2860	membrane
M5598_RS13445	COG0583	DNA-binding transcription factor activity
M5598_RS13450	COG0730	response to heat
M5598_RS13465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5598_RS13470	COG0505	Belongs to the CarA family
M5598_RS13475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M5598_RS13480	COG0494	nUDIX hydrolase
M5598_RS13485	COG0653	protein targeting
M5598_RS13495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M5598_RS13500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5598_RS13505	COG0849	cell division
M5598_RS13510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M5598_RS13515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5598_RS13520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5598_RS13525	COG0772	Belongs to the SEDS family
M5598_RS13530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M5598_RS13535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5598_RS13540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5598_RS13545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M5598_RS13550	COG0768	penicillin binding
M5598_RS13555	COG3116	cell division
M5598_RS13560	COG0275	rRNA processing
M5598_RS13570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M5598_RS13580	COG0792	nuclease activity
M5598_RS13585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M5598_RS13590	COG2823	Periplasmic or secreted lipoprotein
M5598_RS13595	COG2969	positive regulation of protein catabolic process
M5598_RS13600	COG0625	glutathione transferase activity
M5598_RS13605	COG2857	Cytochrome c1
M5598_RS13610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5598_RS13615	COG0723	plastoquinol--plastocyanin reductase activity
M5598_RS13620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M5598_RS13625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M5598_RS13630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M5598_RS13635	COG3105	Protein conserved in bacteria
M5598_RS13645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5598_RS13650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5598_RS13660	COG3150	esterase
M5598_RS13670	COG3151	Protein conserved in bacteria
M5598_RS13675	COG0494	nUDIX hydrolase
M5598_RS13680	COG1538	Outer membrane efflux protein
M5598_RS13685	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M5598_RS13685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M5598_RS13690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M5598_RS13705	COG3025	triphosphatase activity
M5598_RS13710	COG1392	Phosphate transport regulator
M5598_RS13715	COG0306	phosphate transporter
M5598_RS13720	COG4991	sh3 domain protein
M5598_RS13730	COG3267	Type II secretory pathway component ExeA
M5598_RS13730	COG3409	Peptidoglycan-binding domain 1 protein
M5598_RS13735	COG0617	tRNA 3'-terminal CCA addition
M5598_RS13740	COG1968	undecaprenyl-diphosphatase activity
M5598_RS13745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5598_RS13750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M5598_RS13755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M5598_RS13760	COG0596	Alpha beta hydrolase
M5598_RS13765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5598_RS13770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M5598_RS13775	COG1610	YqeY-like protein
M5598_RS13780	COG0358	DNA primase activity
M5598_RS13795	COG1464	Belongs to the NlpA lipoprotein family
M5598_RS13825	COG2213	PTS system mannitol-specific
M5598_RS13825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS13830	COG0246	Mannitol dehydrogenase
M5598_RS13835	COG3722	fumarate hydratase activity
M5598_RS13850	COG1461	Dihydroxyacetone kinase
M5598_RS13855	COG2376	Dihydroxyacetone kinase
M5598_RS13865	COG5002	protein histidine kinase activity
M5598_RS13880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M5598_RS13885	COG1349	DNA-binding transcription factor activity
M5598_RS13890	COG0469	pyruvate kinase activity
M5598_RS13905	COG0440	acetolactate synthase activity
M5598_RS13910	COG0028	Belongs to the TPP enzyme family
M5598_RS13915	COG1022	Amp-dependent synthetase and ligase
M5598_RS13920	COG0583	DNA-binding transcription factor activity
M5598_RS13940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5598_RS13945	COG0473	3-isopropylmalate dehydrogenase activity
M5598_RS13950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M5598_RS13955	COG0066	3-isopropylmalate dehydratase activity
M5598_RS13965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M5598_RS13970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M5598_RS13975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5598_RS13980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M5598_RS13985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5598_RS13990	COG2967	ApaG domain
M5598_RS13995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M5598_RS14010	COG2966	Psort location CytoplasmicMembrane, score
M5598_RS14015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M5598_RS14025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M5598_RS14030	COG0142	geranyltranstransferase activity
M5598_RS14040	COG0039	L-malate dehydrogenase activity
M5598_RS14050	COG2358	TRAP transporter, solute receptor (TAXI family
M5598_RS14065	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M5598_RS14070	COG1178	ABC-type Fe3 transport system permease component
M5598_RS14075	COG4143	(ABC) transporter
M5598_RS14080	COG0163	prenyltransferase activity
M5598_RS14085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5598_RS14090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M5598_RS14095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M5598_RS14105	COG2105	PFAM AIG2 family protein
M5598_RS14110	COG2911	Protein conserved in bacteria
M5598_RS14115	COG0729	surface antigen
M5598_RS14120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_RS14130	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M5598_RS14145	COG1136	(ABC) transporter
M5598_RS14165	COG0529	Catalyzes the synthesis of activated sulfate
M5598_RS14170	COG0471	metal ion transport
M5598_RS14170	COG3273	potassium ion transport
M5598_RS14175	COG2895	sulfate adenylyltransferase (ATP) activity
M5598_RS14180	COG0175	sulfate reduction
M5598_RS14185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5598_RS14185	COG1648	precorrin-2 dehydrogenase activity
M5598_RS14190	COG0737	Belongs to the 5'-nucleotidase family
M5598_RS14205	COG0513	Belongs to the DEAD box helicase family
M5598_RS14210	COG2153	protein acetylation
M5598_RS14220	COG0545	Peptidyl-prolyl cis-trans isomerase
M5598_RS14230	COG0203	ribosomal protein L17
M5598_RS14235	COG0202	RNA polymerase activity
M5598_RS14245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M5598_RS14250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M5598_RS14255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M5598_RS14260	COG0201	protein transport
M5598_RS14265	COG0200	Binds to the 23S rRNA
M5598_RS14270	COG1841	ribosomal large subunit assembly
M5598_RS14285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M5598_RS14290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M5598_RS14295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5598_RS14300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M5598_RS14305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M5598_RS14310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M5598_RS14315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M5598_RS14320	COG0255	Belongs to the universal ribosomal protein uL29 family
M5598_RS14330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M5598_RS14335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M5598_RS14340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M5598_RS14345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M5598_RS14355	COG0088	Forms part of the polypeptide exit tunnel
M5598_RS14360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M5598_RS14370	COG0254	rRNA binding
M5598_RS14375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5598_RS14380	COG1609	Transcriptional regulator
M5598_RS14390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M5598_RS14395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M5598_RS14400	COG1575	Belongs to the MenA family. Type 1 subfamily
M5598_RS14405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5598_RS14410	COG3074	FtsZ-dependent cytokinesis
M5598_RS14415	COG1494	fructose-1,6-bisphosphatase
M5598_RS14440	COG0149	triose-phosphate isomerase activity
M5598_RS14465	COG0438	transferase activity, transferring glycosyl groups
M5598_RS14465	COG1216	Glycosyl transferase, family 2
M5598_RS14475	COG3273	potassium ion transport
M5598_RS14475	COG0471	metal ion transport
M5598_RS14505	COG0438	transferase activity, transferring glycosyl groups
M5598_RS14505	COG1216	Glycosyl transferase, family 2
M5598_RS14530	COG1088	dTDP-glucose 4,6-dehydratase activity
M5598_RS14570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5598_RS14605	COG3156	type II secretion system protein K
M5598_RS14620	COG0175	sulfate reduction
M5598_RS14625	COG0529	Catalyzes the synthesis of activated sulfate
M5598_RS14635	COG2895	sulfate adenylyltransferase (ATP) activity
M5598_RS14640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5598_RS14665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5598_RS14675	COG1560	Kdo2-lipid A biosynthetic process
M5598_RS14680	COG0859	PFAM glycosyl transferase family 9
M5598_RS14685	COG1519	Transferase
M5598_RS14695	COG1083	cytidylyl-transferase
M5598_RS14700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M5598_RS14710	COG2089	acid synthase
M5598_RS14715	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M5598_RS14720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5598_RS14735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5598_RS14755	COG3642	lipopolysaccharide core region biosynthetic process
M5598_RS14760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5598_RS14765	COG0859	PFAM glycosyl transferase family 9
M5598_RS14770	COG0463	Glycosyl transferase, family 2
M5598_RS14795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M5598_RS14810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M5598_RS14815	COG2003	Belongs to the UPF0758 family
M5598_RS14825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5598_RS14830	COG1309	transcriptional regulator
M5598_RS14835	COG1560	Kdo2-lipid A biosynthetic process
M5598_RS14840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5598_RS14845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M5598_RS14850	COG1561	YicC-like family, N-terminal region
M5598_RS14860	COG4608	Belongs to the ABC transporter superfamily
M5598_RS14865	COG0444	Belongs to the ABC transporter superfamily
M5598_RS14870	COG0747	negative chemotaxis
M5598_RS14875	COG4239	(ABC) transporter, permease
M5598_RS14880	COG4174	ABC transporter (Permease)
M5598_RS14900	COG0811	peptide transport
M5598_RS14905	COG0848	biopolymer transport protein
M5598_RS14920	COG0194	GDP metabolic process
M5598_RS14925	COG1758	RNA polymerase activity
M5598_RS14930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5598_RS14935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5598_RS14940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5598_RS14945	COG2233	PERMEase
M5598_RS14965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5598_RS14975	COG2183	response to ionizing radiation
M5598_RS14985	COG0596	Alpha beta hydrolase
M5598_RS14990	COG1040	competence protein
M5598_RS14995	COG0316	Belongs to the HesB IscA family
M5598_RS14995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M5598_RS15000	COG0494	nUDIX hydrolase
M5598_RS15005	COG1218	3'(2'),5'-bisphosphate nucleotidase
M5598_RS15015	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M5598_RS15020	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M5598_RS15025	COG3156	type II secretion system protein K
M5598_RS15030	COG4795	General secretion pathway protein
M5598_RS15035	COG2165	general secretion pathway protein
M5598_RS15040	COG2165	general secretion pathway protein
M5598_RS15045	COG2165	general secretion pathway protein
M5598_RS15050	COG1459	type II secretion system
M5598_RS15055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_RS15065	COG3031	protein transport across the cell outer membrane
M5598_RS15070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M5598_RS15075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M5598_RS15080	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M5598_RS15090	COG0456	acetyltransferase
M5598_RS15095	COG1490	D-aminoacyl-tRNA deacylase activity
M5598_RS15100	COG1295	ribonuclease BN
M5598_RS15115	COG1217	gtp-binding protein TYPA
M5598_RS15120	COG0174	glutamine synthetase
M5598_RS15130	COG3852	Histidine kinase
M5598_RS15135	COG2204	response regulator
M5598_RS15145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M5598_RS15175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M5598_RS15180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_RS15180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_RS15195	COG0084	hydrolase, TatD family'
M5598_RS15205	COG0805	protein transport
M5598_RS15210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5598_RS15215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5598_RS15220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M5598_RS15225	COG3165	ubiquinone biosynthetic process from chorismate
M5598_RS15230	COG2226	methyltransferase
M5598_RS15235	COG1322	Protein conserved in bacteria
M5598_RS15250	COG0628	permease
M5598_RS15300	COG2823	Periplasmic or secreted lipoprotein
M5598_RS15310	COG2081	HI0933 family
M5598_RS15320	COG1528	Iron-storage protein
M5598_RS15325	COG0589	response to stress
M5598_RS15340	COG0742	ribosomal rna small subunit methyltransferase
M5598_RS15345	COG5001	Diguanylate cyclase
M5598_RS15345	COG5002	protein histidine kinase activity
M5598_RS15350	COG1522	sequence-specific DNA binding
M5598_RS15355	COG0339	signal peptide processing
M5598_RS15360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M5598_RS15365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5598_RS15370	COG0583	DNA-binding transcription factor activity
M5598_RS15375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M5598_RS15380	COG0800	Aldolase
M5598_RS15385	COG2610	gluconate transmembrane transporter activity
M5598_RS15390	COG3265	gluconokinase activity
M5598_RS15395	COG0129	dihydroxy-acid dehydratase activity
M5598_RS15410	COG0583	DNA-binding transcription factor activity
M5598_RS15415	COG1609	Transcriptional regulator
M5598_RS15450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5598_RS15455	COG0601	transmembrane transport
M5598_RS15460	COG0747	negative chemotaxis
M5598_RS15465	COG4172	Belongs to the ABC transporter superfamily
M5598_RS15515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS15520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_RS15525	COG2960	long-chain fatty acid transporting porin activity
M5598_RS15530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M5598_RS15535	COG0583	DNA-binding transcription factor activity
M5598_RS15570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M5598_RS15580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M5598_RS15585	COG0408	coproporphyrinogen oxidase activity
M5598_RS15590	COG0009	L-threonylcarbamoyladenylate synthase
M5598_RS15595	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M5598_RS15600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M5598_RS15605	COG0551	DNA topoisomerase type I activity
M5598_RS15610	COG2922	Belongs to the Smg family
M5598_RS15615	COG0758	DNA mediated transformation
M5598_RS15625	COG0242	peptide deformylase activity
M5598_RS15630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M5598_RS15635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5598_RS15635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5598_RS15640	COG0569	domain protein
M5598_RS15645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5598_RS15655	COG1272	protein, Hemolysin III
M5598_RS15660	COG4326	sporulation control protein
M5598_RS15670	COG3084	Protein conserved in bacteria
M5598_RS15680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5598_RS15685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5598_RS15690	COG0204	Acyl-transferase
M5598_RS15700	COG0606	chelatase, subunit chli
M5598_RS15710	COG3978	acetolactate synthase activity
M5598_RS15715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5598_RS15720	COG0129	dihydroxy-acid dehydratase activity
M5598_RS15730	COG0583	DNA-binding transcription factor activity
M5598_RS15735	COG2814	Major facilitator Superfamily
M5598_RS15740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_RS15745	COG0765	amino acid transport
M5598_RS15750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M5598_RS15755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M5598_RS15760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M5598_RS15765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M5598_RS15770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M5598_RS15775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5598_RS15790	COG0356	it plays a direct role in the translocation of protons across the membrane
M5598_RS15795	COG3312	ion transport
M5598_RS15800	COG1475	DNA binding
M5598_RS15805	COG1192	Involved in chromosome partitioning
M5598_RS15810	COG0357	Ribosomal RNA small subunit methyltransferase G
M5598_RS15815	COG0445	tRNA wobble uridine modification
M5598_RS15820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5598_RS15825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M5598_RS15830	COG0706	membrane insertase activity
M5598_RS15840	COG0594	ribonuclease P activity
M5598_RS15850	COG1126	abc transporter atp-binding protein
M5598_RS15865	COG0469	pyruvate kinase activity
M5598_RS15870	COG1126	abc transporter atp-binding protein
M5598_RS15875	COG0765	amino acid transport
M5598_RS15880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_RS15885	COG0765	amino acid transport
M5598_RS15890	COG2203	Gaf domain
M5598_RS15890	COG2200	EAL domain
M5598_RS15890	COG2199	diguanylate cyclase activity
M5598_RS15905	COG1609	Transcriptional regulator
M5598_RS15910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS15910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS15915	COG1105	Belongs to the carbohydrate kinase PfkB family
M5598_RS15920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS15920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS15920	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M5598_RS15960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5598_RS15965	COG0509	glycine decarboxylation via glycine cleavage system
M5598_RS15970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5598_RS15970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5598_RS16005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5598_RS16010	COG0583	DNA-binding transcription factor activity
M5598_RS16015	COG2176	DNA-directed DNA polymerase activity
M5598_RS16055	COG0242	peptide deformylase activity
M5598_RS16085	COG2239	Acts as a magnesium transporter
M5598_RS16105	COG0346	lactoylglutathione lyase activity
M5598_RS16110	COG1902	pentaerythritol trinitrate reductase activity
M5598_RS16130	COG5642	Protein of unknown function (DUF2384)
M5598_RS16135	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M5598_RS16150	COG4565	transcriptional regulatory protein
M5598_RS16155	COG3290	protein histidine kinase activity
M5598_RS16160	COG0471	metal ion transport
M5598_RS16190	COG2076	Multidrug Resistance protein
M5598_RS16205	COG0456	acetyltransferase
M5598_RS16205	COG1214	PFAM Peptidase M22, glycoprotease
M5598_RS16215	COG3069	C4-dicarboxylate transmembrane transporter activity
M5598_RS16225	COG1704	LemA family
M5598_RS16230	COG0501	Belongs to the peptidase M48B family
M5598_RS16255	COG0641	radical SAM
M5598_RS16270	COG3111	PFAM Bacterial OB fold (BOF) protein
M5598_RS16275	COG1597	lipid kinase activity
M5598_RS16280	COG0583	DNA-binding transcription factor activity
M5598_RS16285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5598_RS16315	COG0714	Associated with various cellular activities
M5598_RS16320	COG0641	radical SAM
M5598_RS16325	COG3119	arylsulfatase activity
M5598_RS16340	COG3119	arylsulfatase activity
M5598_RS16345	COG3119	arylsulfatase activity
M5598_RS16350	COG0745	RESPONSE REGULATOR receiver
M5598_RS16365	COG0784	Response regulator, receiver
M5598_RS16365	COG2205	protein histidine kinase activity
M5598_RS16365	COG2198	Histidine kinase
M5598_RS16370	COG1879	ABC-type sugar transport system periplasmic component
M5598_RS16375	COG1803	Methylglyoxal synthase
M5598_RS16380	COG0210	DNA helicase
M5598_RS16385	COG1289	transmembrane transporter activity
M5598_RS16415	COG4771	TonB-dependent receptor
M5598_RS16415	COG1629	transport
M5598_RS16425	COG0789	Transcriptional regulator
M5598_RS16430	COG4604	ABC transporter, ATP-binding protein
M5598_RS16435	COG4605	iron ion homeostasis
M5598_RS16440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5598_RS16445	COG4607	ABC-type enterochelin transport system periplasmic component
M5598_RS16455	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M5598_RS16470	COG1609	Transcriptional regulator
M5598_RS16475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_RS16480	COG1879	ABC-type sugar transport system periplasmic component
M5598_RS16485	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5598_RS16490	COG1129	ABC transporter
M5598_RS16495	COG1869	D-ribose catabolic process
M5598_RS16500	COG5001	Diguanylate cyclase
M5598_RS16505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5598_RS16560	COG0784	Response regulator, receiver
M5598_RS16560	COG2205	protein histidine kinase activity
M5598_RS16575	COG3300	MHYT domain
M5598_RS16575	COG5001	Diguanylate cyclase
M5598_RS16585	COG0330	HflC and HflK could
M5598_RS16600	COG0517	IMP dehydrogenase activity
M5598_RS16600	COG4175	Glycine betaine
M5598_RS16605	COG4176	ABC-type proline glycine betaine transport system permease component
M5598_RS16620	COG1012	belongs to the aldehyde dehydrogenase family
M5598_RS16625	COG1309	transcriptional regulator
M5598_RS16630	COG3706	GGDEF domain
M5598_RS16635	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_RS16650	COG1024	Enoyl-CoA hydratase
M5598_RS16655	COG1960	acyl-CoA dehydrogenase activity
M5598_RS16665	COG0183	Belongs to the thiolase family
M5598_RS16675	COG1960	acyl-CoA dehydrogenase activity
M5598_RS16680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5598_RS16700	COG3437	response regulator, receiver
M5598_RS16700	COG3850	Histidine kinase
M5598_RS16700	COG4999	Histidine kinase
M5598_RS16700	COG2205	protein histidine kinase activity
M5598_RS16715	COG0110	maltose O-acetyltransferase activity
M5598_RS16720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_RS16725	COG1271	oxidase subunit
M5598_RS16730	COG1294	oxidase, subunit
M5598_RS16745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5598_RS16750	COG0789	Transcriptional regulator
M5598_RS16760	COG3474	cytochrome
M5598_RS16825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5598_RS16965	COG4695	Portal protein
M5598_RS17060	COG4974	Belongs to the 'phage' integrase family
M5598_RS17065	COG0516	GMP reductase activity
M5598_RS17070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M5598_RS17070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M5598_RS17085	COG4989	oxidoreductase activity
M5598_RS17100	COG0038	chloride channel
M5598_RS17110	COG1914	H( )-stimulated, divalent metal cation uptake system
M5598_RS17115	COG0302	gtp cyclohydrolase
M5598_RS17125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5598_RS17145	COG2897	thiosulfate sulfurtransferase activity
M5598_RS17165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5598_RS17170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5598_RS17175	COG0840	transmembrane signaling receptor activity
M5598_RS17180	COG2814	Major facilitator Superfamily
M5598_RS17185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M5598_RS17195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5598_RS17205	COG0840	transmembrane signaling receptor activity
M5598_RS17225	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5598_RS17240	COG2197	response regulator
M5598_RS17245	COG3850	Histidine kinase
M5598_RS17250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5598_RS17250	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5598_RS17260	COG0243	molybdopterin cofactor binding
M5598_RS17270	COG3005	denitrification pathway
M5598_RS17290	COG0183	Belongs to the thiolase family
M5598_RS17300	COG1280	lysine exporter protein (LysE YggA)
M5598_RS17310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5598_RS17315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5598_RS17340	COG1522	sequence-specific DNA binding
M5598_RS17360	COG1566	PFAM secretion protein HlyD family protein
M5598_RS17370	COG2205	protein histidine kinase activity
M5598_RS17370	COG0784	Response regulator, receiver
M5598_RS17375	COG1879	ABC-type sugar transport system periplasmic component
M5598_RS17380	COG2827	Endonuclease containing a URI domain
M5598_RS17385	COG3132	Protein of unknown function, DUF480
M5598_RS17395	COG2926	Belongs to the UPF0265 family
M5598_RS17400	COG0534	Mate efflux family protein
M5598_RS17405	COG0673	inositol 2-dehydrogenase activity
M5598_RS17410	COG5002	protein histidine kinase activity
M5598_RS17410	COG0784	Response regulator, receiver
M5598_RS17410	COG2205	protein histidine kinase activity
M5598_RS17430	COG0583	DNA-binding transcription factor activity
M5598_RS17435	COG1522	sequence-specific DNA binding
M5598_RS17440	COG0531	amino acid
M5598_RS17455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M5598_RS17460	COG2239	Acts as a magnesium transporter
M5598_RS17465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M5598_RS17470	COG0402	S-adenosylhomocysteine deaminase activity
M5598_RS17480	COG1418	mRNA catabolic process
M5598_RS17490	COG2814	Major facilitator Superfamily
M5598_RS17500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5598_RS17520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5598_RS17535	COG4221	oxidoreductase activity
M5598_RS17540	COG0745	RESPONSE REGULATOR receiver
M5598_RS17545	COG2205	protein histidine kinase activity
M5598_RS17555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5598_RS17560	COG2194	sulfuric ester hydrolase activity
M5598_RS17565	COG0673	inositol 2-dehydrogenase activity
M5598_RS17605	COG4667	esterase of the alpha-beta hydrolase superfamily
M5598_RS17610	COG1741	Belongs to the pirin family
M5598_RS17615	COG1278	Cold shock
M5598_RS17630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M5598_RS17645	COG1686	Belongs to the peptidase S11 family
M5598_RS17650	COG0625	glutathione transferase activity
M5598_RS17655	COG1621	beta-fructofuranosidase activity
M5598_RS17660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_RS17665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_RS17665	COG1263	PTS System
M5598_RS17685	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_RS17700	COG3746	phosphate-selective porin O and P
M5598_RS17720	COG2207	Transcriptional regulator
M5598_RS17720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5598_RS17725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_RS17745	COG0513	Belongs to the DEAD box helicase family
M5598_RS17755	COG0583	DNA-binding transcription factor activity
M5598_RS17770	COG1902	pentaerythritol trinitrate reductase activity
M5598_RS17775	COG1063	alcohol dehydrogenase
M5598_RS17785	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_RS17795	COG3122	Protein conserved in bacteria
M5598_RS17810	COG0583	DNA-binding transcription factor activity
M5598_RS17815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5598_RS17825	COG0252	asparaginase activity
M5598_RS17830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M5598_RS17835	COG0574	Belongs to the PEP-utilizing enzyme family
M5598_RS17835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5598_RS17850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5598_RS17870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS17890	COG3706	GGDEF domain
M5598_RS17910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5598_RS17940	COG3842	ATPase activity
M5598_RS17990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5598_RS18025	COG0583	DNA-binding transcription factor activity
M5598_RS18035	COG4948	Mandelate Racemase Muconate Lactonizing
M5598_RS18065	COG1342	Belongs to the UPF0251 family
M5598_RS18070	COG3015	lipoprotein NlpE involved in copper resistance
M5598_RS18075	COG3713	MltA-interacting MipA family protein
M5598_RS18090	COG0583	DNA-binding transcription factor activity
M5598_RS18110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M5598_RS18120	COG1335	isochorismatase
M5598_RS18130	COG0753	catalase activity
M5598_RS18140	COG1349	DNA-binding transcription factor activity
M5598_RS18145	COG0346	lactoylglutathione lyase activity
M5598_RS18150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_RS18150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_RS18160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS18165	COG3537	Alpha-1,2-mannosidase
M5598_RS18170	COG3537	Alpha-1,2-mannosidase
M5598_RS18180	COG3537	Alpha-1,2-mannosidase
M5598_RS18185	COG3537	Alpha-1,2-mannosidase
M5598_RS18190	COG2070	2-Nitropropane dioxygenase
M5598_RS18195	COG0737	Belongs to the 5'-nucleotidase family
M5598_RS18205	COG1309	transcriptional regulator
M5598_RS18225	COG1280	lysine exporter protein (LysE YggA)
M5598_RS18240	COG0459	protein refolding
M5598_RS18245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M5598_RS18250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5598_RS18265	COG1304	FMN binding
M5598_RS18285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS18300	COG1706	bacterial-type flagellum-dependent cell motility
M5598_RS18305	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M5598_RS18310	COG4786	Flagellar basal body rod
M5598_RS18315	COG4787	bacterial-type flagellum-dependent cell motility
M5598_RS18320	COG1749	Flagellar hook protein flgE
M5598_RS18325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M5598_RS18330	COG1558	bacterial-type flagellum-dependent cell motility
M5598_RS18335	COG1815	bacterial-type flagellum-dependent cell motility
M5598_RS18355	COG0741	lytic transglycosylase activity
M5598_RS18360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5598_RS18380	COG1760	l-serine dehydratase
M5598_RS18385	COG3104	oligopeptide transport
M5598_RS18405	COG0583	DNA-binding transcription factor activity
M5598_RS18415	COG2866	Carboxypeptidase
M5598_RS18420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5598_RS18455	COG3842	ATPase activity
M5598_RS18465	COG1840	ABC-type Fe3 transport system, periplasmic component
M5598_RS18475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5598_RS18480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5598_RS18485	COG1609	Transcriptional regulator
M5598_RS18515	COG3240	lipase activity
M5598_RS18525	COG1136	(ABC) transporter
M5598_RS18525	COG0577	efflux transmembrane transporter activity
M5598_RS18530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS18535	COG2067	long-chain fatty acid transport protein
M5598_RS18540	COG3338	carbonate dehydratase activity
M5598_RS18545	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M5598_RS18560	COG1011	Hydrolase
M5598_RS18600	COG0110	maltose O-acetyltransferase activity
M5598_RS18605	COG1765	OsmC-like protein
M5598_RS18610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_RS18610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_RS18625	COG3046	protein related to deoxyribodipyrimidine photolyase
M5598_RS18630	COG0415	Belongs to the DNA photolyase family
M5598_RS18635	COG3706	GGDEF domain
M5598_RS18650	COG0840	transmembrane signaling receptor activity
M5598_RS18655	COG3706	GGDEF domain
M5598_RS18670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5598_RS18685	COG3033	Beta-eliminating lyase
M5598_RS18695	COG0579	oxidoreductase
M5598_RS18715	COG2199	diguanylate cyclase activity
M5598_RS18725	COG4191	Histidine kinase
M5598_RS18765	COG0583	DNA-binding transcription factor activity
M5598_RS18770	COG0189	ligase activity
M5598_RS18775	COG0189	ligase activity
M5598_RS18775	COG4067	protein conserved in archaea
M5598_RS18785	COG1166	arginine decarboxylase activity
M5598_RS18790	COG0010	Belongs to the arginase family
M5598_RS18795	COG2814	Major facilitator Superfamily
M5598_RS18800	COG1770	oligopeptidase
M5598_RS18815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5598_RS18820	COG1121	(ABC) transporter
M5598_RS18825	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5598_RS18865	COG0848	biopolymer transport protein
M5598_RS18870	COG0811	peptide transport
M5598_RS18875	COG0811	peptide transport
M5598_RS18895	COG0745	RESPONSE REGULATOR receiver
M5598_RS18900	COG0039	L-malate dehydrogenase activity
M5598_RS18905	COG0584	glycerophosphoryl diester phosphodiesterase
M5598_RS18915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5598_RS18925	COG2207	Transcriptional regulator
M5598_RS18930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5598_RS18935	COG4974	Belongs to the 'phage' integrase family
M5598_RS19005	COG1901	pseudouridine methyltransferase
M5598_RS19010	COG0312	modulator of DNA gyrase
M5598_RS19015	COG0312	modulator of DNA gyrase
M5598_RS19020	COG0351	phosphomethylpyrimidine kinase
M5598_RS19025	COG1116	anion transmembrane transporter activity
M5598_RS19030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5598_RS19035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5598_RS19040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5598_RS19045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M5598_RS19050	COG0352	thiamine-phosphate diphosphorylase activity
M5598_RS19060	COG0243	molybdopterin cofactor binding
M5598_RS19065	COG3005	denitrification pathway
M5598_RS19075	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_RS19090	COG0456	acetyltransferase
M5598_RS19110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_RS19115	COG1929	Belongs to the glycerate kinase type-1 family
M5598_RS19120	COG2610	gluconate transmembrane transporter activity
M5598_RS19125	COG3835	regulator
M5598_RS19165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M5598_RS19170	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M5598_RS19170	COG3408	Glycogen debranching enzyme
M5598_RS19200	COG3047	cAMP biosynthetic process
M5598_RS19205	COG1357	PFAM Pentapeptide repeats (8 copies)
M5598_RS19240	COG2375	cellular response to nickel ion
M5598_RS19245	COG0583	DNA-binding transcription factor activity
M5598_RS19250	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M5598_RS19255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M5598_RS19270	COG2199	diguanylate cyclase activity
M5598_RS19280	COG0561	phosphatase activity
M5598_RS19285	COG0583	DNA-binding transcription factor activity
M5598_RS19300	COG0564	pseudouridine synthase activity
M5598_RS19305	COG0534	Mate efflux family protein
M5598_RS19310	COG5001	Diguanylate cyclase
M5598_RS19320	COG3123	guanosine phosphorylase activity
M5598_RS19360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5598_RS19370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5598_RS19375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M5598_RS19385	COG2259	Doxx family
M5598_RS19390	COG1741	Belongs to the pirin family
M5598_RS19410	COG0363	glucosamine-6-phosphate deaminase activity
M5598_RS19420	COG0786	glutamate:sodium symporter activity
M5598_RS19425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_RS19430	COG1131	(ABC) transporter
M5598_RS19440	COG0786	glutamate:sodium symporter activity
M5598_RS19465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5598_RS19475	COG3279	Response regulator of the LytR AlgR family
M5598_RS19480	COG3275	phosphorelay sensor kinase activity
M5598_RS19500	COG1136	(ABC) transporter
M5598_RS19510	COG0772	Belongs to the SEDS family
M5598_RS19515	COG0217	transcriptional regulatory protein
M5598_RS19535	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
M5598_RS19535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5598_RS19545	COG0444	Belongs to the ABC transporter superfamily
M5598_RS19550	COG4608	Belongs to the ABC transporter superfamily
M5598_RS19580	COG1444	tRNA N-acetyltransferase activity
M5598_RS19600	COG3340	Belongs to the peptidase S51 family
M5598_RS19605	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M5598_RS19610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_RS19610	COG1263	PTS System
M5598_RS19615	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M5598_RS19630	COG4166	transmembrane transport
M5598_RS19675	COG0259	pyridoxamine-phosphate oxidase activity
M5598_RS19700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5598_RS19745	COG1132	(ABC) transporter
M5598_RS19780	COG0800	Aldolase
M5598_RS19785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_RS19790	COG1904	glucuronate isomerase
M5598_RS19795	COG0246	Mannitol dehydrogenase
M5598_RS19805	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M5598_RS19815	COG2186	Transcriptional regulator
M5598_RS19820	COG1312	Catalyzes the dehydration of D-mannonate
M5598_RS19825	COG0513	Belongs to the DEAD box helicase family
M5598_RS19830	COG2258	MOSC domain
M5598_RS19845	COG1486	melibiose metabolic process
M5598_RS19850	COG0583	DNA-binding transcription factor activity
M5598_RS19865	COG1595	DNA-templated transcription, initiation
M5598_RS19900	COG3634	alkyl hydroperoxide reductase activity
M5598_RS19910	COG1846	Transcriptional regulator
M5598_RS19915	COG1764	response to oxidative stress
M5598_RS19940	COG2160	L-arabinose isomerase activity
M5598_RS19950	COG1069	ribulokinase activity
M5598_RS19955	COG1879	ABC-type sugar transport system periplasmic component
M5598_RS19960	COG1129	ABC transporter
M5598_RS19965	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5598_RS19970	COG0826	peptidase U32
M5598_RS19995	COG1653	transport
M5598_RS20000	COG0019	diaminopimelate decarboxylase activity
M5598_RS20005	COG4264	IucA IucC family
M5598_RS20025	COG4774	siderophore transport
M5598_RS20030	COG4772	TonB-dependent receptor
M5598_RS20035	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M5598_RS20040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5598_RS20045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5598_RS20050	COG1120	ATPase activity
M5598_RS20055	COG0840	transmembrane signaling receptor activity
M5598_RS20060	COG0612	Peptidase, M16
M5598_RS20070	COG0739	heme binding
M5598_RS20095	COG4580	involved in the transport of maltose and maltodextrins
M5598_RS20115	COG2356	endonuclease I
M5598_RS20135	COG1982	Orn Lys Arg decarboxylase major
M5598_RS20140	COG0531	amino acid
M5598_RS20150	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M5598_RS20160	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M5598_RS20165	COG1162	GTPase activity
M5598_RS20170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_RS20170	COG1263	PTS System
M5598_RS20180	COG1999	signal sequence binding
M5598_RS20195	COG2909	trisaccharide binding
M5598_RS20205	COG0058	SHG alpha-glucan phosphorylase activity
M5598_RS20210	COG1640	4-alpha-glucanotransferase
M5598_RS20215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M5598_RS20220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5598_RS20225	COG0366	Alpha amylase catalytic
M5598_RS20240	COG3366	ferrous iron transmembrane transporter activity
M5598_RS20245	COG0700	Nucleoside recognition
M5598_RS20250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5598_RS20255	COG3339	Conserved Protein
M5598_RS20260	COG1301	dicarboxylic acid transport
M5598_RS20270	COG0583	DNA-binding transcription factor activity
M5598_RS20295	COG2095	MarC family integral membrane protein
M5598_RS20300	COG4667	esterase of the alpha-beta hydrolase superfamily
M5598_RS20305	COG3397	chitin binding
M5598_RS20310	COG1054	Belongs to the UPF0176 family
M5598_RS20325	COG1686	Belongs to the peptidase S11 family
M5598_RS20350	COG0583	DNA-binding transcription factor activity
M5598_RS20355	COG4628	conserved protein (DUF2132)
M5598_RS20365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5598_RS20375	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M5598_RS20380	COG0628	permease
M5598_RS20420	COG2814	Major facilitator Superfamily
M5598_RS20430	COG0454	-acetyltransferase
M5598_RS20440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5598_RS20445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M5598_RS20450	COG1882	Formate acetyltransferase
M5598_RS20480	COG1360	Flagellar Motor Protein
M5598_RS20485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5598_RS20490	COG1191	sigma factor activity
M5598_RS20495	COG1580	Controls the rotational direction of flagella during chemotaxis
M5598_RS20510	COG1516	flagellar protein fliS
M5598_RS20515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M5598_RS20530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_RS20545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5598_RS20555	COG1987	bacterial-type flagellum assembly
M5598_RS20635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5598_RS20655	COG0346	lactoylglutathione lyase activity
M5598_RS20680	COG0745	RESPONSE REGULATOR receiver
M5598_RS20700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_RS20710	COG0156	8-amino-7-oxononanoate synthase activity
M5598_RS20715	COG1063	alcohol dehydrogenase
M5598_RS20745	COG3338	carbonate dehydratase activity
M5598_RS20750	COG0668	transmembrane transport
M5598_RS20760	COG1304	FMN binding
M5598_RS20765	COG1620	l-lactate permease
M5598_RS20770	COG0583	DNA-binding transcription factor activity
M5598_RS20775	COG1505	serine-type exopeptidase activity
M5598_RS20780	COG4172	Belongs to the ABC transporter superfamily
M5598_RS20790	COG1067	ATP-dependent peptidase activity
M5598_RS20815	COG1247	-acetyltransferase
M5598_RS20820	COG0437	4 iron, 4 sulfur cluster binding
M5598_RS20825	COG0348	domain, Protein
M5598_RS20840	COG1122	ATPase activity
M5598_RS20845	COG4720	Psort location CytoplasmicMembrane, score
M5598_RS20850	COG1566	PFAM secretion protein HlyD family protein
M5598_RS20860	COG3706	GGDEF domain
M5598_RS20875	COG0813	purine-nucleoside phosphorylase activity
M5598_RS20880	COG3272	Protein of unknown function (DUF1722)
M5598_RS20885	COG0789	Transcriptional regulator
M5598_RS20890	COG0415	Belongs to the DNA photolyase family
M5598_RS20895	COG1388	LysM domain
M5598_RS20895	COG1376	ErfK ybiS ycfS ynhG family protein
M5598_RS20905	COG0513	Belongs to the DEAD box helicase family
M5598_RS20910	COG1770	oligopeptidase
M5598_RS20915	COG4771	TonB-dependent receptor
M5598_RS20945	COG0573	inorganic phosphate transmembrane transporter activity
M5598_RS20950	COG0581	inorganic phosphate transmembrane transporter activity
M5598_RS20955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5598_RS20970	COG2304	oxidoreductase activity
M5598_RS20990	COG0714	Associated with various cellular activities
M5598_RS20995	COG0840	transmembrane signaling receptor activity
M5598_RS21005	COG2197	response regulator
M5598_RS21040	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M5598_RS21045	COG1120	ATPase activity
M5598_RS21050	COG4774	siderophore transport
M5598_RS21055	COG1132	(ABC) transporter
M5598_RS21060	COG2205	protein histidine kinase activity
M5598_RS21060	COG2205	protein histidine kinase activity
M5598_RS21070	COG0569	domain protein
M5598_RS21075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5598_RS21085	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M5598_RS21090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5598_RS21105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS21105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS21105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS21110	COG2207	Transcriptional regulator
M5598_RS21120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS21125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_RS21130	COG2084	Dehydrogenase
M5598_RS21135	COG0753	catalase activity
M5598_RS21145	COG2130	NADP-dependent
M5598_RS21150	COG1309	transcriptional regulator
M5598_RS21155	COG3097	Belongs to the UPF0267 family
M5598_RS21215	COG3842	ATPase activity
M5598_RS21225	COG1175	transmembrane transport
M5598_RS21230	COG3833	ABC-type maltose transport systems, permease component
M5598_RS21260	COG2354	Protein conserved in bacteria
M5598_RS21265	COG0418	dihydroorotase activity
M5598_RS21270	COG0401	homolog of Blt101
M5598_RS21275	COG3217	Mosc domain protein beta barrel domain protein
M5598_RS21275	COG0633	Ferredoxin
M5598_RS21275	COG0633	Ferredoxin
M5598_RS21275	COG3217	Mosc domain protein beta barrel domain protein
M5598_RS21280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M5598_RS21285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M5598_RS21325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M5598_RS21330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5598_RS21340	COG0848	biopolymer transport protein
M5598_RS21345	COG0811	peptide transport
M5598_RS21350	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M5598_RS21360	COG3721	Heme iron utilization protein
M5598_RS21365	COG0748	coenzyme F420 binding
M5598_RS21375	COG0784	Response regulator, receiver
M5598_RS21375	COG0835	chemotaxis
M5598_RS21380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5598_RS21390	COG0596	Alpha beta hydrolase
M5598_RS21400	COG0583	DNA-binding transcription factor activity
M5598_RS21425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M5598_RS21430	COG0783	Belongs to the Dps family
M5598_RS21435	COG0583	DNA-binding transcription factor activity
M5598_RS21450	COG4934	collagen metabolic process
M5598_RS21460	COG0366	Alpha amylase catalytic
M5598_RS21480	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5598_RS21485	COG0589	response to stress
M5598_RS21490	COG0488	(ABC) transporter
M5598_RS21495	COG1505	serine-type exopeptidase activity
M5598_RS21505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_RS21515	COG2067	long-chain fatty acid transport protein
M5598_RS21525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5598_RS21555	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_RS21575	COG3383	formate dehydrogenase (NAD+) activity
M5598_RS21590	COG0842	Transport permease protein
M5598_RS21595	COG1131	(ABC) transporter
M5598_RS21610	COG2706	6-phosphogluconolactonase activity
M5598_RS21620	COG1881	PFAM PEBP family protein
M5598_RS21630	COG0798	PFAM Bile acid sodium symporter
M5598_RS21645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_RS21650	COG2213	PTS system mannitol-specific
M5598_RS21655	COG1063	alcohol dehydrogenase
M5598_RS21665	COG1072	(Pantothenic acid kinase))
M5598_RS21670	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5598_RS21690	COG0814	amino acid
M5598_RS21705	COG3314	Sporulation integral membrane protein YlbJ
M5598_RS21725	COG0739	heme binding
M5598_RS21730	COG5001	Diguanylate cyclase
M5598_RS21735	COG0583	DNA-binding transcription factor activity
M5598_RS21740	COG2814	Major facilitator Superfamily
M5598_RS21760	COG0697	spore germination
M5598_RS21765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M5598_RS21790	COG2207	Transcriptional regulator
M5598_RS21795	COG1280	lysine exporter protein (LysE YggA)
M5598_RS21805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5598_RS21810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5598_RS21820	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M5598_RS21845	COG1612	heme a metabolic process
M5598_RS21850	COG0109	protoheme IX farnesyltransferase activity
M5598_RS21855	COG0545	Peptidyl-prolyl cis-trans isomerase
M5598_RS21885	COG1278	Cold shock
M5598_RS21890	COG3036	rescue of stalled ribosome
M5598_RS21900	COG0840	transmembrane signaling receptor activity
M5598_RS21910	COG2199	diguanylate cyclase activity
M5598_RS21930	COG0577	efflux transmembrane transporter activity
M5598_RS21930	COG1136	(ABC) transporter
M5598_RS21940	COG0840	transmembrane signaling receptor activity
M5598_RS21945	COG0783	Belongs to the Dps family
M5598_RS21955	COG2133	pyrroloquinoline quinone binding
M5598_RS21960	COG1454	alcohol dehydrogenase
M5598_RS21965	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M5598_RS21995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5598_RS22000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5598_RS22005	COG3186	Phenylalanine-4-hydroxylase
M5598_RS22010	COG2154	pterin-4-alpha-carbinolamine dehydratase
M5598_RS22030	COG3530	Putative quorum-sensing-regulated virulence factor
M5598_RS22035	COG0513	Belongs to the DEAD box helicase family
M5598_RS22040	COG4628	conserved protein (DUF2132)
M5598_RS22045	COG0133	tryptophan synthase activity
M5598_RS22055	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M5598_RS22065	COG0523	cobalamin synthesis protein
M5598_RS22070	COG0513	Belongs to the DEAD box helicase family
M5598_RS22090	COG2200	EAL domain
M5598_RS22095	COG1119	ATPase activity
M5598_RS22100	COG0840	transmembrane signaling receptor activity
M5598_RS22120	COG0641	radical SAM
M5598_RS22140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M5598_RS22155	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M5598_RS22160	COG0513	Belongs to the DEAD box helicase family
M5598_RS22165	COG5001	Diguanylate cyclase
M5598_RS22170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5598_RS22185	COG5413	integral membrane protein
M5598_RS22195	COG1024	Enoyl-CoA hydratase
M5598_RS22200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5598_RS22205	COG1960	acyl-CoA dehydrogenase activity
M5598_RS22215	COG0183	Belongs to the thiolase family
M5598_RS22230	COG1024	Enoyl-CoA hydratase
M5598_RS22235	COG1024	Enoyl-CoA hydratase
M5598_RS22245	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_RS22250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5598_RS22255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5598_RS22260	COG1845	cytochrome c oxidase, subunit III
M5598_RS22265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5598_RS22270	COG0109	protoheme IX farnesyltransferase activity
M5598_RS22280	COG1902	pentaerythritol trinitrate reductase activity
M5598_RS22290	COG1126	abc transporter atp-binding protein
M5598_RS22295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_RS22300	COG4215	(ABC) transporter
M5598_RS22305	COG4160	amino acid transport
M5598_RS22320	COG0625	glutathione transferase activity
M5598_RS22355	COG0443	Heat shock 70 kDa protein
M5598_RS22360	COG2847	Copper chaperone PCu(A)C
M5598_RS22385	COG0745	RESPONSE REGULATOR receiver
M5598_RS22400	COG1785	Belongs to the alkaline phosphatase family
M5598_RS22425	COG0814	amino acid
M5598_RS22435	COG0243	molybdopterin cofactor binding
M5598_RS22455	COG3707	response regulator
M5598_RS22460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5598_RS22465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5598_RS22470	COG1116	anion transmembrane transporter activity
M5598_RS22475	COG2146	nitrite reductase [NAD(P)H] activity
M5598_RS22475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5598_RS22530	COG2815	serine threonine protein kinase
M5598_RS22530	COG0515	serine threonine protein kinase
M5598_RS22565	COG0631	protein serine/threonine phosphatase activity
M5598_RS22635	COG0420	3'-5' exonuclease activity
M5598_RS22640	COG0419	ATPase involved in DNA repair
M5598_RS22660	COG3040	lipid binding
M5598_RS22670	COG2814	Major facilitator Superfamily
M5598_RS22690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5598_RS22740	COG3300	MHYT domain
M5598_RS22740	COG5001	Diguanylate cyclase
M5598_RS22745	COG2197	response regulator
M5598_RS22750	COG3706	GGDEF domain
M5598_RS22760	COG2197	response regulator
M5598_RS22780	COG0784	Response regulator, receiver
M5598_RS22780	COG0835	chemotaxis
M5598_RS22795	COG2962	Rard protein
M5598_RS22805	COG0671	phosphoesterase, PA-phosphatase related
M5598_RS22815	COG1288	antiporter activity
M5598_RS22825	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M5598_RS22840	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M5598_RS22855	COG0583	DNA-binding transcription factor activity
M5598_RS22860	COG0277	FAD linked oxidase domain protein
M5598_RS22875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5598_RS22915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5598_RS22915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5598_RS22950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5598_RS22955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5598_RS22965	COG2116	formate transmembrane transporter activity
M5598_RS22985	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M5598_RS23015	COG0534	Mate efflux family protein
M5598_RS23020	COG0745	RESPONSE REGULATOR receiver
M5598_RS23020	COG2205	protein histidine kinase activity
M5598_RS23020	COG3292	Two component regulator propeller
M5598_RS23030	COG3118	belongs to the thioredoxin family
M5598_RS23035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5598_RS23060	COG2271	Major facilitator Superfamily
M5598_RS23065	COG3851	Histidine kinase
M5598_RS23070	COG2197	response regulator
M5598_RS23080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M5598_RS23085	COG0583	DNA-binding transcription factor activity
M5598_RS23090	COG0243	molybdopterin cofactor binding
M5598_RS23120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_RS23135	COG1328	CTP reductase activity
M5598_RS23140	COG0602	queuosine metabolic process
M5598_RS23145	COG0534	Mate efflux family protein
M5598_RS23160	COG4067	protein conserved in archaea
M5598_RS23160	COG0189	ligase activity
M5598_RS23170	COG3111	PFAM Bacterial OB fold (BOF) protein
M5598_RS23175	COG1492	cobalamin metabolic process
M5598_RS23180	COG0725	ABC transporter, periplasmic molybdate-binding protein
M5598_RS23185	COG4149	molybdate abc transporter
M5598_RS23190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M5598_RS23200	COG5001	Diguanylate cyclase
M5598_RS23200	COG4251	negative regulation of phosphorylation
M5598_RS23200	COG3706	GGDEF domain
M5598_RS23200	COG2203	Gaf domain
M5598_RS23225	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M5598_RS23230	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M5598_RS23255	COG3140	Belongs to the UPF0181 family
M5598_RS23260	COG0589	response to stress
M5598_RS23305	COG4128	Pfam Zonular occludens toxin
M5598_RS23350	COG0023	Translation Initiation Factor
M5598_RS23360	COG1181	Belongs to the D-alanine--D-alanine ligase family
M5598_RS23370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5598_RS23370	COG1042	CoA-binding domain protein
M5598_RS23370	COG0045	succinate-CoA ligase (ADP-forming) activity
M5598_RS23375	COG0583	DNA-binding transcription factor activity
M5598_RS23390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5598_RS23395	COG5002	protein histidine kinase activity
M5598_RS23395	COG5001	Diguanylate cyclase
M5598_RS23395	COG3447	MASE1 domain protein
M5598_RS23400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M5598_RS23405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M5598_RS23410	COG1984	allophanate hydrolase subunit 2
M5598_RS23420	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M5598_RS23425	COG4181	ATPase activity
M5598_RS23435	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M5598_RS23440	COG5001	Diguanylate cyclase
M5598_RS23440	COG3300	MHYT domain
M5598_RS23450	COG0484	heat shock protein binding
M5598_RS23475	COG4533	DNA binding
M5598_RS23485	COG2050	protein possibly involved in aromatic compounds catabolism
M5598_RS23500	COG2067	long-chain fatty acid transport protein
M5598_RS23505	COG2267	carboxylic ester hydrolase activity
M5598_RS23520	COG0861	Integral membrane protein TerC family
M5598_RS23525	COG0737	Belongs to the 5'-nucleotidase family
M5598_RS23530	COG3593	DNA synthesis involved in DNA repair
M5598_RS23540	COG0583	DNA-binding transcription factor activity
M5598_RS23545	COG2116	formate transmembrane transporter activity
M5598_RS23550	COG2353	YceI-like domain
M5598_RS23555	COG3038	cytochrome b561
M5598_RS23570	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M5598_RS23575	COG0513	Belongs to the DEAD box helicase family
M5598_RS23580	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M5598_RS23590	COG0546	phosphoglycolate phosphatase activity
M5598_RS23595	COG3437	response regulator, receiver
M5598_RS23595	COG0784	Response regulator, receiver
M5598_RS23610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_RS23615	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M5598_RS23620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M5598_RS23630	COG2207	Transcriptional regulator
M5598_RS23635	COG1979	alcohol dehydrogenase
M5598_RS23660	COG2271	Major facilitator Superfamily
M5598_RS23810	COG1160	GTP binding
M5598_RS23865	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
M5598_RS23885	COG0628	permease
M5598_RS24000	COG0629	single-stranded DNA binding
M5598_RS24100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5598_RS24200	COG3341	Caulimovirus viroplasmin
M5598_RS24200	COG0328	RNA-DNA hybrid ribonuclease activity
M5598_RS24255	COG1058	Belongs to the CinA family
M5598_RS24255	COG1546	Belongs to the CinA family
M5598_RS24285	COG2137	regulation of response to DNA damage stimulus
M5598_RS24320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5598_RS24325	COG1358	cellular component organization or biogenesis
M5598_RS24450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5598_RS24455	COG2194	sulfuric ester hydrolase activity
M5598_RS24465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5598_RS24525	COG0105	UTP biosynthetic process
M5598_RS24670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_RS24670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_RS24710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M5598_RS24780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5598_RS24810	COG0602	queuosine metabolic process
M5598_RS24815	COG0776	regulation of translation
M5598_RS24910	COG2304	oxidoreductase activity
M5598_RS24915	COG1570	exodeoxyribonuclease VII activity
M5598_RS24930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5598_RS25180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M5598_RS25270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5598_RS25295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5598_RS25305	COG0822	iron-sulfur transferase activity
M5598_RS25325	COG1435	thymidine kinase activity
M5598_RS25350	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M5598_RS25370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M5598_RS25375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M5598_RS25415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5598_RS25435	COG2353	YceI-like domain
M5598_RS25440	COG3038	cytochrome b561
M5598_RS25465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5598_RS25470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5598_RS25505	COG1358	cellular component organization or biogenesis
M5598_RS25520	COG2310	stress, protein
M5598_RS25535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5598_RS25560	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5598_RS25575	COG3706	GGDEF domain
M5598_RS25890	COG0210	DNA helicase
M5598_RS26005	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M5598_RS26085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5598_RS26105	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M5598_RS26150	COG0653	protein targeting
M5598_RS26160	COG1078	dGTPase activity
M5598_RS26180	COG0497	DNA recombination
M5598_RS26215	COG2974	May be involved in recombination
M5598_RS26285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_RS26320	COG0514	ATP-dependent DNA helicase (RecQ)
M5598_RS26330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5598_RS26340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5598_RS26360	COG0750	zinc metalloprotease
M5598_RS26370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5598_RS26375	COG0305	Participates in initiation and elongation during chromosome replication
M5598_RS26380	COG0587	DNA-directed DNA polymerase activity
M5598_RS26395	COG0316	Belongs to the HesB IscA family
M5598_RS26400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5598_RS26420	COG2200	EAL domain
M5598_RS26435	COG0210	DNA helicase
M5598_RS26445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5598_RS26485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_RS26485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_RS26490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M5598_RS26550	COG2925	Exonuclease
M5598_RS26610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_RS26625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_RS26715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M5598_RS26900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5598_RS26900	COG0678	peroxiredoxin activity
M5598_RS27155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M5598_RS27235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_RS27250	COG3550	peptidyl-serine autophosphorylation
M5598_RS27380	COG2137	regulation of response to DNA damage stimulus
M5598_RS27450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5598_RS27455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5598_RS27465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5598_RS27520	COG1199	ATP-dependent helicase activity
M5598_RS27560	COG3093	addiction module antidote protein HigA
M5598_RS27685	COG0494	nUDIX hydrolase
M5598_RS27820	COG2916	Histone family protein nucleoid-structuring protein H-NS
M5598_RS27875	COG0671	phosphoesterase, PA-phosphatase related
M5598_RS27880	COG0671	phosphoesterase, PA-phosphatase related
M5598_RS27915	COG0629	single-stranded DNA binding
M5598_RS28090	COG0148	phosphopyruvate hydratase activity
M5598_RS28270	COG4682	membrane
M5598_RS28425	COG1129	ABC transporter
M5598_RS28665	COG1328	CTP reductase activity
M5598_RS28915	COG0194	GDP metabolic process
M5598_RS29080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5598_RS29180	COG1253	flavin adenine dinucleotide binding
M5598_RS29225	COG0776	regulation of translation
M5598_RS29230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5598_RS29235	COG1192	Involved in chromosome partitioning
M5598_RS29265	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M5598_RS29330	COG1278	Cold shock