locus-tag	class	description
IHE41_RS00005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IHE41_RS00010	COG2137	regulation of response to DNA damage stimulus
IHE41_RS00015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IHE41_RS00020	COG0527	aspartate kinase activity
IHE41_RS00085	COG3630	sodium ion export across plasma membrane
IHE41_RS00090	COG0511	ligase activity, forming carbon-carbon bonds
IHE41_RS00090	COG5016	pyruvate
IHE41_RS00095	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IHE41_RS00105	COG1238	metal cluster binding
IHE41_RS00110	COG0612	Peptidase, M16
IHE41_RS00115	COG2918	glutathione biosynthetic process
IHE41_RS00125	COG1854	S-ribosylhomocysteine lyase activity
IHE41_RS00130	COG4536	flavin adenine dinucleotide binding
IHE41_RS00135	COG4137	Cytochrome C assembly protein
IHE41_RS00140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IHE41_RS00145	COG0228	four-way junction DNA binding
IHE41_RS00150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IHE41_RS00155	COG0336	Belongs to the RNA methyltransferase TrmD family
IHE41_RS00160	COG0335	large ribosomal subunit rRNA binding
IHE41_RS00165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IHE41_RS00170	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IHE41_RS00175	COG0237	dephospho-CoA kinase activity
IHE41_RS00185	COG1459	type II secretion system
IHE41_RS00190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IHE41_RS00200	COG0157	Belongs to the NadC ModD family
IHE41_RS00210	COG2186	Transcriptional regulator
IHE41_RS00215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IHE41_RS00220	COG0508	dehydrogenase complex catalyzes the overall conversion of
IHE41_RS00225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IHE41_RS00240	COG0288	reversible hydration of carbon dioxide
IHE41_RS00245	COG0659	secondary active sulfate transmembrane transporter activity
IHE41_RS00250	COG1131	(ABC) transporter
IHE41_RS00255	COG0842	Transport permease protein
IHE41_RS00260	COG1560	Kdo2-lipid A biosynthetic process
IHE41_RS00265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IHE41_RS00270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IHE41_RS00275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IHE41_RS00285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IHE41_RS00295	COG1489	DNA binding
IHE41_RS00300	COG1643	Atp-dependent helicase
IHE41_RS00305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IHE41_RS00310	COG1752	Esterase of the alpha-beta hydrolase superfamily
IHE41_RS00315	COG1049	propionate catabolic process, 2-methylcitrate cycle
IHE41_RS00320	COG3112	Uncharacterised protein family (UPF0231)
IHE41_RS00330	COG0004	ammonium transporteR
IHE41_RS00335	COG1840	ABC-type Fe3 transport system, periplasmic component
IHE41_RS00350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IHE41_RS00365	COG2971	BadF BadG BcrA BcrD
IHE41_RS00375	COG4608	Belongs to the ABC transporter superfamily
IHE41_RS00380	COG0444	Belongs to the ABC transporter superfamily
IHE41_RS00385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IHE41_RS00395	COG0747	negative chemotaxis
IHE41_RS00400	COG2205	protein histidine kinase activity
IHE41_RS00400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHE41_RS00400	COG0784	Response regulator, receiver
IHE41_RS00400	COG2198	Histidine kinase
IHE41_RS00405	COG2813	Specifically methylates the guanine in position
IHE41_RS00410	COG0628	permease
IHE41_RS00415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IHE41_RS00420	COG0316	Belongs to the HesB IscA family
IHE41_RS00430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IHE41_RS00435	COG0739	heme binding
IHE41_RS00440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IHE41_RS00450	COG2027	D-alanyl-D-alanine carboxypeptidase
IHE41_RS00455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IHE41_RS00460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IHE41_RS00465	COG1534	Rna-binding protein
IHE41_RS00470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IHE41_RS00475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IHE41_RS00480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IHE41_RS00485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IHE41_RS00490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IHE41_RS00505	COG0779	Required for maturation of 30S ribosomal subunits
IHE41_RS00510	COG0195	Participates in both transcription termination and antitermination
IHE41_RS00515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IHE41_RS00520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IHE41_RS00525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IHE41_RS00530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IHE41_RS00535	COG1185	polyribonucleotide nucleotidyltransferase activity
IHE41_RS00550	COG0534	Mate efflux family protein
IHE41_RS00555	COG0826	peptidase U32
IHE41_RS00560	COG0826	peptidase U32
IHE41_RS00570	COG3154	lipid carrier protein
IHE41_RS00575	COG3153	acetyltransferase
IHE41_RS00595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IHE41_RS00605	COG0084	hydrolase, TatD family'
IHE41_RS00610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IHE41_RS00615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IHE41_RS00620	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IHE41_RS00625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IHE41_RS00630	COG0813	purine-nucleoside phosphorylase activity
IHE41_RS00640	COG0560	Phosphoserine phosphatase
IHE41_RS00650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IHE41_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IHE41_RS00660	COG0583	DNA-binding transcription factor activity
IHE41_RS00670	COG1022	Amp-dependent synthetase and ligase
IHE41_RS00675	COG2169	Transcriptional regulator
IHE41_RS00700	COG4964	Belongs to the GSP D family
IHE41_RS00760	COG0583	DNA-binding transcription factor activity
IHE41_RS00765	COG0531	amino acid
IHE41_RS00770	COG2731	YhcH YjgK YiaL family protein
IHE41_RS00775	COG3250	beta-galactosidase activity
IHE41_RS00780	COG1609	Transcriptional regulator
IHE41_RS00785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IHE41_RS00795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IHE41_RS00800	COG2017	converts alpha-aldose to the beta-anomer
IHE41_RS00815	COG2211	Major facilitator Superfamily
IHE41_RS00820	COG1609	Transcriptional regulator
IHE41_RS00825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHE41_RS00845	COG0598	Magnesium transport protein CorA
IHE41_RS00850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IHE41_RS00855	COG1349	DNA-binding transcription factor activity
IHE41_RS00860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IHE41_RS00865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IHE41_RS00870	COG2271	Major facilitator Superfamily
IHE41_RS00875	COG0584	glycerophosphoryl diester phosphodiesterase
IHE41_RS00880	COG2171	N-acyltransferase activity
IHE41_RS00885	COG3141	response to X-ray
IHE41_RS00905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IHE41_RS00910	COG1074	ATP-dependent DNA helicase activity
IHE41_RS00915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IHE41_RS00925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IHE41_RS00925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IHE41_RS00935	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IHE41_RS00940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IHE41_RS00945	COG2166	iron-sulfur cluster assembly
IHE41_RS00950	COG3706	GGDEF domain
IHE41_RS00955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IHE41_RS00960	COG0693	protein deglycase activity
IHE41_RS00965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IHE41_RS00990	COG1595	DNA-templated transcription, initiation
IHE41_RS01010	COG3056	Lipoprotein
IHE41_RS01015	COG2813	Specifically methylates the guanine in position
IHE41_RS01020	COG0271	Belongs to the BolA IbaG family
IHE41_RS01025	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IHE41_RS01030	COG1805	sodium ion transport
IHE41_RS01035	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IHE41_RS01040	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IHE41_RS01045	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IHE41_RS01050	COG2871	sodium ion transport
IHE41_RS01055	COG1477	protein flavinylation
IHE41_RS01070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IHE41_RS01075	COG0514	ATP-dependent DNA helicase (RecQ)
IHE41_RS01080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IHE41_RS01095	COG0733	neurotransmitter:sodium symporter activity
IHE41_RS01115	COG0442	prolyl-tRNA aminoacylation
IHE41_RS01120	COG1720	tRNA m6t6A37 methyltransferase activity
IHE41_RS01125	COG0254	rRNA binding
IHE41_RS01135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IHE41_RS01140	COG1671	Belongs to the UPF0178 family
IHE41_RS01165	COG3098	single-species biofilm formation
IHE41_RS01170	COG0564	pseudouridine synthase activity
IHE41_RS01180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IHE41_RS01185	COG0024	Methionine aminopeptidase
IHE41_RS01190	COG0052	Belongs to the universal ribosomal protein uS2 family
IHE41_RS01195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IHE41_RS01200	COG0528	UMP kinase activity
IHE41_RS01205	COG0233	cytoplasmic translational termination
IHE41_RS01210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IHE41_RS01215	COG0575	Belongs to the CDS family
IHE41_RS01220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IHE41_RS01225	COG0750	zinc metalloprotease
IHE41_RS01235	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IHE41_RS01240	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IHE41_RS01245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IHE41_RS01250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IHE41_RS01255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IHE41_RS01260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IHE41_RS01265	COG0587	DNA-directed DNA polymerase activity
IHE41_RS01270	COG0825	malonyl-CoA metabolic process
IHE41_RS01275	COG0037	tRNA processing
IHE41_RS01285	COG0347	Belongs to the P(II) protein family
IHE41_RS01290	COG3021	interspecies interaction between organisms
IHE41_RS01300	COG1388	LysM domain
IHE41_RS01300	COG0741	lytic transglycosylase activity
IHE41_RS01305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHE41_RS01310	COG2226	methyltransferase
IHE41_RS01315	COG0328	RNA-DNA hybrid ribonuclease activity
IHE41_RS01320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IHE41_RS01335	COG0456	acetyltransferase
IHE41_RS01345	COG1960	acyl-CoA dehydrogenase activity
IHE41_RS01350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IHE41_RS01355	COG0121	glutamine amidotransferase
IHE41_RS01360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IHE41_RS01365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IHE41_RS01370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IHE41_RS01375	COG2233	PERMEase
IHE41_RS01395	COG1393	Belongs to the ArsC family
IHE41_RS01400	COG4783	chaperone-mediated protein folding
IHE41_RS01430	COG2199	diguanylate cyclase activity
IHE41_RS01430	COG2200	EAL domain
IHE41_RS01430	COG2202	Pas domain
IHE41_RS01535	COG4789	Type iii secretion
IHE41_RS01540	COG4792	protein secretion
IHE41_RS01570	COG3710	Transcriptional regulator
IHE41_RS01585	COG4790	Type iii secretion
IHE41_RS01675	COG2916	Histone family protein nucleoid-structuring protein H-NS
IHE41_RS01690	COG2207	Transcriptional regulator
IHE41_RS01705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IHE41_RS01715	COG0747	negative chemotaxis
IHE41_RS01735	COG0804	urea catabolic process
IHE41_RS01800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IHE41_RS01830	COG2716	regulation of RNA biosynthetic process
IHE41_RS01835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IHE41_RS01840	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IHE41_RS01855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IHE41_RS01860	COG1393	Belongs to the ArsC family
IHE41_RS01885	COG2837	iron assimilation
IHE41_RS01890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS01895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS01900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS01905	COG1334	flagellar protein FlaG
IHE41_RS01910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IHE41_RS01920	COG1516	flagellar protein fliS
IHE41_RS01940	COG1677	Flagellar hook-basal body complex protein FliE
IHE41_RS01950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IHE41_RS02000	COG1987	bacterial-type flagellum assembly
IHE41_RS02005	COG1684	flagellar biosynthetic protein fliR
IHE41_RS02040	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IHE41_RS02045	COG2198	Histidine kinase
IHE41_RS02045	COG0643	Histidine kinase
IHE41_RS02045	COG0784	Response regulator, receiver
IHE41_RS02050	COG2201	protein-glutamate methylesterase activity
IHE41_RS02055	COG1192	Involved in chromosome partitioning
IHE41_RS02065	COG0835	chemotaxis
IHE41_RS02075	COG4133	protoheme IX ABC transporter activity
IHE41_RS02080	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IHE41_RS02085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IHE41_RS02090	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IHE41_RS02095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IHE41_RS02100	COG1138	Cytochrome C-type biogenesis protein
IHE41_RS02105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHE41_RS02120	COG2853	Lipoprotein
IHE41_RS02130	COG2067	long-chain fatty acid transport protein
IHE41_RS02145	COG0183	Belongs to the thiolase family
IHE41_RS02150	COG1024	Enoyl-CoA hydratase
IHE41_RS02150	COG1250	3-hydroxyacyl-CoA dehydrogenase
IHE41_RS02165	COG2062	phosphohistidine phosphatase, SixA
IHE41_RS02170	COG2840	Smr protein MutS2
IHE41_RS02175	COG2890	protein-(glutamine-N5) methyltransferase activity
IHE41_RS02180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IHE41_RS02185	COG2860	membrane
IHE41_RS02190	COG3101	peptidyl-lysine hydroxylation
IHE41_RS02200	COG0431	NADPH-dependent FMN reductase
IHE41_RS02205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IHE41_RS02205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IHE41_RS02210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IHE41_RS02215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IHE41_RS02220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IHE41_RS02230	COG0101	tRNA pseudouridine synthase activity
IHE41_RS02235	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IHE41_RS02240	COG0285	dihydrofolate synthase activity
IHE41_RS02245	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IHE41_RS02250	COG1286	toxin biosynthetic process
IHE41_RS02255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IHE41_RS02260	COG0583	DNA-binding transcription factor activity
IHE41_RS02265	COG0745	RESPONSE REGULATOR receiver
IHE41_RS02275	COG2832	Protein of unknown function (DUF454)
IHE41_RS02280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IHE41_RS02290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IHE41_RS02295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IHE41_RS02300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IHE41_RS02305	COG0814	amino acid
IHE41_RS02310	COG0251	oxidation-reduction process
IHE41_RS02315	COG3681	Belongs to the UPF0597 family
IHE41_RS02330	COG2261	transglycosylase associated protein
IHE41_RS02335	COG2983	Belongs to the UPF0260 family
IHE41_RS02340	COG0668	transmembrane transport
IHE41_RS02345	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IHE41_RS02350	COG0346	lactoylglutathione lyase activity
IHE41_RS02360	COG1785	Belongs to the alkaline phosphatase family
IHE41_RS02375	COG2226	methyltransferase
IHE41_RS02390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IHE41_RS02395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IHE41_RS02405	COG3139	Protein of unknown function (DUF1315)
IHE41_RS02410	COG0252	asparaginase activity
IHE41_RS02415	COG0616	signal peptide processing
IHE41_RS02420	COG0446	pyridine nucleotide-disulphide oxidoreductase
IHE41_RS02420	COG1902	pentaerythritol trinitrate reductase activity
IHE41_RS02425	COG0778	Nitroreductase
IHE41_RS02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IHE41_RS02445	COG0123	including yeast histone deacetylase and acetoin utilization protein
IHE41_RS02455	COG3083	sulfuric ester hydrolase activity
IHE41_RS02460	COG3082	Protein of unknown function (DUF1414)
IHE41_RS02465	COG3081	Nucleoid-associated protein
IHE41_RS02480	COG1757	Na H antiporter
IHE41_RS02485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IHE41_RS02490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IHE41_RS02495	COG2095	MarC family integral membrane protein
IHE41_RS02500	COG1012	belongs to the aldehyde dehydrogenase family
IHE41_RS02500	COG1454	alcohol dehydrogenase
IHE41_RS02520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IHE41_RS02530	COG2056	Na+-H+ antiporter family
IHE41_RS02535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IHE41_RS02540	COG2885	chlorophyll binding
IHE41_RS02550	COG0346	lactoylglutathione lyase activity
IHE41_RS02555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IHE41_RS02560	COG4660	Part of a membrane complex involved in electron transport
IHE41_RS02565	COG4659	FMN binding
IHE41_RS02570	COG4658	electron transport chain
IHE41_RS02575	COG4656	Part of a membrane complex involved in electron transport
IHE41_RS02580	COG2878	Part of a membrane complex involved in electron transport
IHE41_RS02585	COG4657	Part of a membrane complex involved in electron transport
IHE41_RS02595	COG0556	nucleotide-excision repair
IHE41_RS02600	COG2204	response regulator
IHE41_RS02605	COG2198	Histidine kinase
IHE41_RS02610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IHE41_RS02615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IHE41_RS02620	COG0521	Mo-molybdopterin cofactor biosynthetic process
IHE41_RS02625	COG0315	cyclic pyranopterin monophosphate synthase activity
IHE41_RS02630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IHE41_RS02635	COG0314	molybdopterin synthase activity
IHE41_RS02645	COG0601	transmembrane transport
IHE41_RS02650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IHE41_RS02655	COG0444	Belongs to the ABC transporter superfamily
IHE41_RS02665	COG0435	Glutathione S-transferase
IHE41_RS02675	COG3174	membrane
IHE41_RS02680	COG0857	belongs to the CobB CobQ family
IHE41_RS02680	COG0280	phosphate acetyltransferase
IHE41_RS02685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IHE41_RS02690	COG3092	negative regulation of chromosome organization
IHE41_RS02700	COG4120	Belongs to the binding-protein-dependent transport system permease family
IHE41_RS02705	COG1122	ATPase activity
IHE41_RS02720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IHE41_RS02725	COG0653	protein targeting
IHE41_RS02730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IHE41_RS02735	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IHE41_RS02740	COG2186	Transcriptional regulator
IHE41_RS02750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHE41_RS02750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHE41_RS02755	COG0489	protein tyrosine kinase activity
IHE41_RS02760	COG0572	uridine kinase
IHE41_RS02770	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IHE41_RS02775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IHE41_RS02780	COG0659	secondary active sulfate transmembrane transporter activity
IHE41_RS02785	COG1530	ribonuclease E activity
IHE41_RS02790	COG0564	pseudouridine synthase activity
IHE41_RS02795	COG0424	maF-like protein
IHE41_RS02800	COG1399	metal-binding, possibly nucleic acid-binding protein
IHE41_RS02810	COG0416	fatty acid biosynthetic process
IHE41_RS02815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IHE41_RS02845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IHE41_RS02850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IHE41_RS02860	COG0084	hydrolase, TatD family'
IHE41_RS02865	COG1263	PTS System
IHE41_RS02865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHE41_RS02880	COG0733	neurotransmitter:sodium symporter activity
IHE41_RS02895	COG4667	esterase of the alpha-beta hydrolase superfamily
IHE41_RS02900	COG0469	pyruvate kinase activity
IHE41_RS02905	COG1940	carbohydrate kinase activity
IHE41_RS02910	COG0784	Response regulator, receiver
IHE41_RS02910	COG0835	chemotaxis
IHE41_RS02915	COG0587	DNA-directed DNA polymerase activity
IHE41_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS02935	COG0616	signal peptide processing
IHE41_RS02940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IHE41_RS02945	COG0539	negative regulation of cytoplasmic translation
IHE41_RS02955	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IHE41_RS02960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IHE41_RS02965	COG0284	orotidine-5'-phosphate decarboxylase activity
IHE41_RS02970	COG4166	transmembrane transport
IHE41_RS02995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IHE41_RS03005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IHE41_RS03005	COG3008	intermembrane lipid transfer
IHE41_RS03010	COG2995	paraquat-inducible protein a
IHE41_RS03015	COG3258	Cytochrome c
IHE41_RS03020	COG2863	cytochrome
IHE41_RS03060	COG4232	protein-disulfide reductase activity
IHE41_RS03065	COG3118	belongs to the thioredoxin family
IHE41_RS03095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS03105	COG0577	efflux transmembrane transporter activity
IHE41_RS03105	COG1136	(ABC) transporter
IHE41_RS03115	COG0577	efflux transmembrane transporter activity
IHE41_RS03115	COG1136	(ABC) transporter
IHE41_RS03150	COG0583	DNA-binding transcription factor activity
IHE41_RS03155	COG0583	DNA-binding transcription factor activity
IHE41_RS03200	COG3850	Histidine kinase
IHE41_RS03200	COG5002	protein histidine kinase activity
IHE41_RS03205	COG0745	RESPONSE REGULATOR receiver
IHE41_RS03210	COG0840	transmembrane signaling receptor activity
IHE41_RS03215	COG1032	radical SAM domain protein
IHE41_RS03220	COG2203	Gaf domain
IHE41_RS03220	COG3706	GGDEF domain
IHE41_RS03220	COG4251	negative regulation of phosphorylation
IHE41_RS03220	COG5001	Diguanylate cyclase
IHE41_RS03235	COG0583	DNA-binding transcription factor activity
IHE41_RS03240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IHE41_RS03250	COG2350	Protein conserved in bacteria
IHE41_RS03260	COG2917	probably involved in intracellular septation
IHE41_RS03280	COG1301	dicarboxylic acid transport
IHE41_RS03285	COG0318	PFAM AMP-dependent synthetase and ligase
IHE41_RS03290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IHE41_RS03295	COG0159	tryptophan synthase activity
IHE41_RS03300	COG0133	tryptophan synthase activity
IHE41_RS03305	COG0135	phosphoribosylanthranilate isomerase activity
IHE41_RS03305	COG0134	indole-3-glycerol-phosphate synthase activity
IHE41_RS03310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IHE41_RS03315	COG0512	Glutamine amidotransferase of anthranilate synthase
IHE41_RS03320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IHE41_RS03330	COG0613	PHP domain protein
IHE41_RS03335	COG0009	L-threonylcarbamoyladenylate synthase
IHE41_RS03345	COG1187	pseudouridine synthase activity
IHE41_RS03350	COG3099	Belongs to the UPF0263 family
IHE41_RS03355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IHE41_RS03365	COG0417	DNA replication proofreading
IHE41_RS03370	COG2197	response regulator
IHE41_RS03375	COG0322	excinuclease ABC activity
IHE41_RS03415	COG0019	diaminopimelate decarboxylase activity
IHE41_RS03440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IHE41_RS03445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IHE41_RS03450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IHE41_RS03470	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IHE41_RS03480	COG0437	4 iron, 4 sulfur cluster binding
IHE41_RS03485	COG3301	Polysulphide reductase, NrfD
IHE41_RS03490	COG1138	Cytochrome C-type biogenesis protein
IHE41_RS03500	COG4235	cytochrome complex assembly
IHE41_RS03500	COG3088	subunit of a heme lyase
IHE41_RS03510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IHE41_RS03535	COG2989	Protein conserved in bacteria
IHE41_RS03540	COG3108	Peptidase M15
IHE41_RS03545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHE41_RS03560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IHE41_RS03585	COG1846	Transcriptional regulator
IHE41_RS03590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IHE41_RS03595	COG0840	transmembrane signaling receptor activity
IHE41_RS03615	COG1448	Aminotransferase
IHE41_RS03630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHE41_RS03640	COG0017	Asparaginyl-tRNA synthetase
IHE41_RS03645	COG0840	transmembrane signaling receptor activity
IHE41_RS03650	COG0720	synthase
IHE41_RS03660	COG2200	EAL domain
IHE41_RS03665	COG1760	l-serine dehydratase
IHE41_RS03670	COG0814	amino acid
IHE41_RS03675	COG0494	nUDIX hydrolase
IHE41_RS03685	COG0784	Response regulator, receiver
IHE41_RS03685	COG2205	protein histidine kinase activity
IHE41_RS03690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IHE41_RS03705	COG3106	COG3106 Predicted ATPase
IHE41_RS03710	COG3768	UPF0283 membrane protein
IHE41_RS03720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHE41_RS03830	COG2801	Transposase and inactivated derivatives
IHE41_RS03875	COG2801	Transposase and inactivated derivatives
IHE41_RS03905	COG0456	acetyltransferase
IHE41_RS04000	COG1192	Involved in chromosome partitioning
IHE41_RS04080	COG2801	Transposase and inactivated derivatives
IHE41_RS04145	COG2801	Transposase and inactivated derivatives
IHE41_RS04180	COG1757	Na H antiporter
IHE41_RS04185	COG0174	glutamine synthetase
IHE41_RS04190	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IHE41_RS04195	COG1396	sequence-specific DNA binding
IHE41_RS04195	COG1917	Cupin 2, conserved barrel domain protein
IHE41_RS04200	COG1012	belongs to the aldehyde dehydrogenase family
IHE41_RS04205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IHE41_RS04215	COG2957	Belongs to the agmatine deiminase family
IHE41_RS04220	COG1012	belongs to the aldehyde dehydrogenase family
IHE41_RS04225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IHE41_RS04230	COG1227	inorganic diphosphatase activity
IHE41_RS04235	COG2771	luxR family
IHE41_RS04235	COG2200	EAL domain
IHE41_RS04245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IHE41_RS04260	COG1846	Transcriptional regulator
IHE41_RS04265	COG2315	Protein conserved in bacteria
IHE41_RS04285	COG0110	maltose O-acetyltransferase activity
IHE41_RS04315	COG3063	Type IV pilus biogenesis stability protein PilW
IHE41_RS04320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IHE41_RS04330	COG0531	amino acid
IHE41_RS04335	COG1560	Kdo2-lipid A biosynthetic process
IHE41_RS04340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IHE41_RS04345	COG1280	lysine exporter protein (LysE YggA)
IHE41_RS04355	COG1115	amino acid carrier protein
IHE41_RS04380	COG1368	sulfuric ester hydrolase activity
IHE41_RS04385	COG0642	Histidine kinase
IHE41_RS04390	COG0745	RESPONSE REGULATOR receiver
IHE41_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS04410	COG1022	Amp-dependent synthetase and ligase
IHE41_RS04420	COG2113	Glycine betaine
IHE41_RS04425	COG4176	ABC-type proline glycine betaine transport system permease component
IHE41_RS04445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IHE41_RS04450	COG0456	acetyltransferase
IHE41_RS04455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IHE41_RS04460	COG0662	Cupin 2, conserved barrel domain protein
IHE41_RS04465	COG0527	aspartate kinase activity
IHE41_RS04470	COG1858	cytochrome C peroxidase
IHE41_RS04485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS04500	COG3290	protein histidine kinase activity
IHE41_RS04505	COG4565	transcriptional regulatory protein
IHE41_RS04510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IHE41_RS04515	COG0363	glucosamine-6-phosphate deaminase activity
IHE41_RS04520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IHE41_RS04535	COG3284	Transcriptional regulator
IHE41_RS04540	COG1012	belongs to the aldehyde dehydrogenase family
IHE41_RS04610	COG4669	(LipO)protein
IHE41_RS04630	COG3177	Filamentation induced by cAMP protein fic
IHE41_RS04665	COG0583	DNA-binding transcription factor activity
IHE41_RS04675	COG1073	alpha beta
IHE41_RS04680	COG1073	alpha beta
IHE41_RS04690	COG4792	protein secretion
IHE41_RS04695	COG4791	protein targeting
IHE41_RS04700	COG4794	Type iii secretion
IHE41_RS04705	COG4790	Type iii secretion
IHE41_RS04775	COG0457	Tetratricopeptide repeat
IHE41_RS04795	COG0730	response to heat
IHE41_RS04825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IHE41_RS04830	COG0372	Belongs to the citrate synthase family
IHE41_RS04840	COG2828	Protein conserved in bacteria
IHE41_RS04865	COG0561	phosphatase activity
IHE41_RS04870	COG0602	queuosine metabolic process
IHE41_RS04875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IHE41_RS04880	COG3706	GGDEF domain
IHE41_RS04935	COG0840	transmembrane signaling receptor activity
IHE41_RS04940	COG1254	Belongs to the acylphosphatase family
IHE41_RS04945	COG2920	part of a sulfur-relay system
IHE41_RS04955	COG0670	Belongs to the BI1 family
IHE41_RS04960	COG1126	abc transporter atp-binding protein
IHE41_RS04965	COG0765	amino acid transport
IHE41_RS04970	COG4597	amino acid ABC transporter
IHE41_RS04975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHE41_RS04985	COG1666	GTP binding
IHE41_RS04990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IHE41_RS05010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IHE41_RS05010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IHE41_RS05015	COG3008	intermembrane lipid transfer
IHE41_RS05020	COG2995	paraquat-inducible protein a
IHE41_RS05025	COG1132	(ABC) transporter
IHE41_RS05030	COG1956	GAF domain-containing protein
IHE41_RS05035	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IHE41_RS05050	COG0308	aminopeptidase N
IHE41_RS05060	COG2902	Dehydrogenase
IHE41_RS05065	COG0167	dihydroorotate dehydrogenase activity
IHE41_RS05075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IHE41_RS05075	COG0116	Belongs to the methyltransferase superfamily
IHE41_RS05085	COG0488	(ABC) transporter
IHE41_RS05100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IHE41_RS05105	COG1067	ATP-dependent peptidase activity
IHE41_RS05110	COG3120	sequence-specific DNA binding
IHE41_RS05175	COG0784	Response regulator, receiver
IHE41_RS05175	COG2205	protein histidine kinase activity
IHE41_RS05190	COG3278	Belongs to the heme-copper respiratory oxidase family
IHE41_RS05205	COG2010	Cytochrome c
IHE41_RS05215	COG2217	Heavy metal translocating P-type atpase
IHE41_RS05230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IHE41_RS05235	COG0589	response to stress
IHE41_RS05240	COG0037	tRNA processing
IHE41_RS05260	COG3842	ATPase activity
IHE41_RS05270	COG1177	transmembrane transport
IHE41_RS05280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IHE41_RS05285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IHE41_RS05295	COG0004	ammonium transporteR
IHE41_RS05320	COG0437	4 iron, 4 sulfur cluster binding
IHE41_RS05325	COG0243	molybdopterin cofactor binding
IHE41_RS05325	COG3383	formate dehydrogenase (NAD+) activity
IHE41_RS05335	COG3381	protein complex oligomerization
IHE41_RS05355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IHE41_RS05360	COG0488	(ABC) transporter
IHE41_RS05365	COG4191	Histidine kinase
IHE41_RS05370	COG2204	response regulator
IHE41_RS05385	COG3842	ATPase activity
IHE41_RS05390	COG0746	molybdenum cofactor guanylyltransferase activity
IHE41_RS05395	COG0303	'Molybdopterin
IHE41_RS05405	COG1940	carbohydrate kinase activity
IHE41_RS05410	COG3148	PFAM DTW domain containing protein
IHE41_RS05440	COG3290	protein histidine kinase activity
IHE41_RS05440	COG0840	transmembrane signaling receptor activity
IHE41_RS05445	COG0791	NLP P60 protein
IHE41_RS05455	COG3706	GGDEF domain
IHE41_RS05460	COG2201	protein-glutamate methylesterase activity
IHE41_RS05465	COG3001	Fructosamine kinase
IHE41_RS05475	COG0307	riboflavin synthase, alpha
IHE41_RS05480	COG0534	Mate efflux family protein
IHE41_RS05490	COG1793	dna ligase
IHE41_RS05520	COG2204	response regulator
IHE41_RS05530	COG0438	transferase activity, transferring glycosyl groups
IHE41_RS05560	COG0438	transferase activity, transferring glycosyl groups
IHE41_RS05565	COG1215	transferase activity, transferring glycosyl groups
IHE41_RS05570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IHE41_RS05580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IHE41_RS05595	COG1643	Atp-dependent helicase
IHE41_RS05600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IHE41_RS05615	COG3302	dmso reductase anchor subunit
IHE41_RS05620	COG0437	4 iron, 4 sulfur cluster binding
IHE41_RS05625	COG0243	molybdopterin cofactor binding
IHE41_RS05665	COG0443	Heat shock 70 kDa protein
IHE41_RS05670	COG0443	Heat shock 70 kDa protein
IHE41_RS05695	COG1132	(ABC) transporter
IHE41_RS05700	COG1132	(ABC) transporter
IHE41_RS05720	COG0814	amino acid
IHE41_RS05730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IHE41_RS05810	COG1522	sequence-specific DNA binding
IHE41_RS05845	COG0515	serine threonine protein kinase
IHE41_RS05870	COG3501	Rhs element vgr protein
IHE41_RS05910	COG0739	heme binding
IHE41_RS05915	COG0861	Integral membrane protein TerC family
IHE41_RS05925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IHE41_RS05930	COG1328	CTP reductase activity
IHE41_RS05935	COG1280	lysine exporter protein (LysE YggA)
IHE41_RS05945	COG3300	MHYT domain
IHE41_RS05945	COG5001	Diguanylate cyclase
IHE41_RS05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHE41_RS05955	COG4191	Histidine kinase
IHE41_RS05960	COG0471	metal ion transport
IHE41_RS05995	COG0583	DNA-binding transcription factor activity
IHE41_RS06000	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IHE41_RS06070	COG0758	DNA mediated transformation
IHE41_RS06200	COG1783	phage Terminase large subunit
IHE41_RS06210	COG1475	DNA binding
IHE41_RS06255	COG0557	exoribonuclease II activity
IHE41_RS06260	COG1278	Cold shock
IHE41_RS06365	COG0625	glutathione transferase activity
IHE41_RS06375	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IHE41_RS06385	COG2195	Cleaves the N-terminal amino acid of tripeptides
IHE41_RS06395	COG0601	transmembrane transport
IHE41_RS06400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IHE41_RS06405	COG0444	Belongs to the ABC transporter superfamily
IHE41_RS06420	COG3291	Pkd domain containing protein
IHE41_RS06430	COG1177	transmembrane transport
IHE41_RS06435	COG1176	ABC-type spermidine putrescine transport system, permease component I
IHE41_RS06440	COG3842	ATPase activity
IHE41_RS06445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IHE41_RS06450	COG2423	ornithine cyclodeaminase activity
IHE41_RS06465	COG3938	Belongs to the proline racemase family
IHE41_RS06495	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IHE41_RS06500	COG1451	nucleotide metabolic process
IHE41_RS06505	COG3475	LICD family
IHE41_RS06510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IHE41_RS06515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IHE41_RS06535	COG0583	DNA-binding transcription factor activity
IHE41_RS06555	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
IHE41_RS06560	COG4139	cobalamin transport
IHE41_RS06565	COG2988	succinylglutamate desuccinylase activity
IHE41_RS06585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IHE41_RS06590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IHE41_RS06595	COG0702	epimerase
IHE41_RS06600	COG1823	symporter activity
IHE41_RS06605	COG2925	Exonuclease
IHE41_RS06610	COG1380	Effector of murein hydrolase LrgA
IHE41_RS06615	COG1346	cytolysis
IHE41_RS06620	COG0295	cytidine deaminase activity
IHE41_RS06625	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IHE41_RS06630	COG0500	methyltransferase
IHE41_RS06640	COG0776	regulation of translation
IHE41_RS06650	COG0072	phenylalanine-tRNA ligase activity
IHE41_RS06650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHE41_RS06655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IHE41_RS06660	COG3706	GGDEF domain
IHE41_RS06690	COG0393	Putative heavy-metal-binding
IHE41_RS06700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IHE41_RS06710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IHE41_RS06725	COG2188	Transcriptional regulator
IHE41_RS06730	COG1228	amidohydrolase
IHE41_RS06735	COG0010	Belongs to the arginase family
IHE41_RS06740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IHE41_RS06745	COG2986	histidine ammonia-lyase
IHE41_RS06760	COG0247	lactate metabolic process
IHE41_RS06760	COG0277	FAD linked oxidase domain protein
IHE41_RS06795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IHE41_RS06810	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
IHE41_RS06815	COG1643	Atp-dependent helicase
IHE41_RS06820	COG0281	malic enzyme
IHE41_RS06825	COG2949	membrane
IHE41_RS06830	COG0471	metal ion transport
IHE41_RS06855	COG0492	ferredoxin-NADP+ reductase activity
IHE41_RS06860	COG4988	ABC transporter
IHE41_RS06865	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IHE41_RS06870	COG3048	D-serine ammonia-lyase activity
IHE41_RS06875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IHE41_RS06885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHE41_RS06885	COG4191	Histidine kinase
IHE41_RS06900	COG3070	regulator of competence-specific genes
IHE41_RS06910	COG2431	L-lysine efflux transmembrane transporter activity
IHE41_RS06920	COG0076	glutamate decarboxylase activity
IHE41_RS06925	COG1737	Transcriptional regulator
IHE41_RS06935	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IHE41_RS06940	COG3273	potassium ion transport
IHE41_RS06940	COG2985	domain, Protein
IHE41_RS06945	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IHE41_RS06960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IHE41_RS06975	COG1136	(ABC) transporter
IHE41_RS06980	COG0534	Mate efflux family protein
IHE41_RS06985	COG0702	epimerase
IHE41_RS06990	COG3005	denitrification pathway
IHE41_RS07020	COG2814	Major facilitator Superfamily
IHE41_RS07025	COG1187	pseudouridine synthase activity
IHE41_RS07030	COG1061	Type III restriction enzyme res subunit
IHE41_RS07050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IHE41_RS07075	COG3313	Fe-S protein
IHE41_RS07100	COG0493	'glutamate synthase
IHE41_RS07110	COG0398	Pfam SNARE associated Golgi protein
IHE41_RS07115	COG4134	Bacterial extracellular solute-binding protein
IHE41_RS07120	COG4135	transport system, permease component
IHE41_RS07125	COG4136	ATPase activity
IHE41_RS07130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IHE41_RS07140	COG3604	Transcriptional regulator
IHE41_RS07145	COG1151	hydroxylamine reductase activity
IHE41_RS07150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IHE41_RS07160	COG0564	pseudouridine synthase activity
IHE41_RS07170	COG0733	neurotransmitter:sodium symporter activity
IHE41_RS07180	COG0626	cystathionine gamma-synthase activity
IHE41_RS07185	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IHE41_RS07190	COG5380	lipid catabolic process
IHE41_RS07195	COG0519	Catalyzes the synthesis of GMP from XMP
IHE41_RS07210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS07215	COG1983	PspC domain protein
IHE41_RS07225	COG1842	Phage shock protein A
IHE41_RS07230	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IHE41_RS07245	COG4171	peptide transport system, permease
IHE41_RS07255	COG4172	Belongs to the ABC transporter superfamily
IHE41_RS07265	COG1227	inorganic diphosphatase activity
IHE41_RS07280	COG0243	molybdopterin cofactor binding
IHE41_RS07285	COG3005	denitrification pathway
IHE41_RS07290	COG4459	periplasmic nitrate reductase
IHE41_RS07295	COG0390	transport system, permease component
IHE41_RS07305	COG2116	formate transmembrane transporter activity
IHE41_RS07330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IHE41_RS07335	COG1435	thymidine kinase activity
IHE41_RS07340	COG0215	cysteine-tRNA ligase activity
IHE41_RS07345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IHE41_RS07350	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IHE41_RS07355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IHE41_RS07360	COG3012	SEC-C Motif Domain Protein
IHE41_RS07365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IHE41_RS07365	COG0140	phosphoribosyl-ATP diphosphatase activity
IHE41_RS07370	COG0107	imidazoleglycerol-phosphate synthase activity
IHE41_RS07410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IHE41_RS07415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IHE41_RS07420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IHE41_RS07420	COG0131	Imidazoleglycerol-phosphate dehydratase
IHE41_RS07425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IHE41_RS07430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IHE41_RS07435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IHE41_RS07450	COG1757	Na H antiporter
IHE41_RS07460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHE41_RS07470	COG0482	sulfurtransferase activity
IHE41_RS07475	COG2915	High frequency lysogenization protein hflD homolog
IHE41_RS07480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IHE41_RS07500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IHE41_RS07515	COG0300	oxidoreductase activity
IHE41_RS07525	COG0501	Belongs to the peptidase M48B family
IHE41_RS07535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IHE41_RS07545	COG0156	8-amino-7-oxononanoate synthase activity
IHE41_RS07550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IHE41_RS07555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IHE41_RS07560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IHE41_RS07575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IHE41_RS07580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IHE41_RS07585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IHE41_RS07590	COG1674	ftsk spoiiie
IHE41_RS07600	COG0686	Belongs to the AlaDH PNT family
IHE41_RS07610	COG0583	DNA-binding transcription factor activity
IHE41_RS07625	COG3568	Endonuclease Exonuclease Phosphatase
IHE41_RS07650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IHE41_RS07655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS07660	COG0840	transmembrane signaling receptor activity
IHE41_RS07680	COG0328	RNA-DNA hybrid ribonuclease activity
IHE41_RS07715	COG5002	protein histidine kinase activity
IHE41_RS07715	COG0784	Response regulator, receiver
IHE41_RS07725	COG0754	glutathionylspermidine amidase activity
IHE41_RS07735	COG3766	membrane
IHE41_RS07745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IHE41_RS07750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IHE41_RS07755	COG2885	chlorophyll binding
IHE41_RS07760	COG0823	Involved in the tonB-independent uptake of proteins
IHE41_RS07775	COG0811	peptide transport
IHE41_RS07780	COG0824	Thioesterase
IHE41_RS07790	COG4890	Cyd operon protein YbgT
IHE41_RS07795	COG1294	oxidase, subunit
IHE41_RS07800	COG1271	oxidase subunit
IHE41_RS07805	COG2255	four-way junction helicase activity
IHE41_RS07810	COG0632	four-way junction helicase activity
IHE41_RS07815	COG0840	transmembrane signaling receptor activity
IHE41_RS07820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IHE41_RS07825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IHE41_RS07830	COG1801	Protein of unknown function DUF72
IHE41_RS07835	COG4106	trans-aconitate 2-methyltransferase activity
IHE41_RS07840	COG0500	methyltransferase
IHE41_RS07845	COG0189	ligase activity
IHE41_RS07845	COG4067	protein conserved in archaea
IHE41_RS07865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IHE41_RS07870	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IHE41_RS07875	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
IHE41_RS07880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IHE41_RS07885	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IHE41_RS07890	COG0745	RESPONSE REGULATOR receiver
IHE41_RS07895	COG3381	protein complex oligomerization
IHE41_RS07900	COG1609	Transcriptional regulator
IHE41_RS07905	COG3070	regulator of competence-specific genes
IHE41_RS07925	COG0297	glycogen (starch) synthase activity
IHE41_RS07930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IHE41_RS07935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IHE41_RS07945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IHE41_RS07955	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IHE41_RS07960	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IHE41_RS07965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IHE41_RS07975	COG0542	response to heat
IHE41_RS07980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IHE41_RS07985	COG1278	Cold shock
IHE41_RS07995	COG1187	pseudouridine synthase activity
IHE41_RS08000	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IHE41_RS08010	COG1199	ATP-dependent helicase activity
IHE41_RS08015	COG0730	response to heat
IHE41_RS08020	COG3923	Primosomal replication protein n
IHE41_RS08030	COG0708	Exodeoxyribonuclease III
IHE41_RS08070	COG1882	Formate acetyltransferase
IHE41_RS08080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IHE41_RS08090	COG3013	Belongs to the UPF0304 family
IHE41_RS08095	COG2766	serine protein kinase
IHE41_RS08100	COG2718	Belongs to the UPF0229 family
IHE41_RS08105	COG2719	SpoVR family
IHE41_RS08110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IHE41_RS08120	COG1663	tetraacyldisaccharide 4'-kinase activity
IHE41_RS08125	COG1132	(ABC) transporter
IHE41_RS08130	COG0658	competence protein
IHE41_RS08130	COG2333	competence protein COMEC
IHE41_RS08140	COG4591	ABC-type transport system involved in lipoprotein release permease component
IHE41_RS08145	COG1136	(ABC) transporter
IHE41_RS08150	COG4591	ABC-type transport system involved in lipoprotein release permease component
IHE41_RS08160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IHE41_RS08175	COG1252	NADH dehydrogenase
IHE41_RS08180	COG3150	esterase
IHE41_RS08205	COG0537	adenosine 5'-monophosphoramidase activity
IHE41_RS08230	COG0516	GMP reductase activity
IHE41_RS08230	COG0517	IMP dehydrogenase activity
IHE41_RS08235	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IHE41_RS08240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IHE41_RS08245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IHE41_RS08255	COG2199	diguanylate cyclase activity
IHE41_RS08270	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IHE41_RS08275	COG1946	Acyl-CoA thioesterase
IHE41_RS08305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IHE41_RS08310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS08355	COG0477	Major facilitator Superfamily
IHE41_RS08360	COG2855	membrane
IHE41_RS08380	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IHE41_RS08385	COG0596	Alpha beta hydrolase
IHE41_RS08390	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IHE41_RS08395	COG1169	isochorismate synthase
IHE41_RS08400	COG0436	Aminotransferase
IHE41_RS08405	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IHE41_RS08410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IHE41_RS08425	COG1555	photosystem II stabilization
IHE41_RS08430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IHE41_RS08435	COG0776	regulation of translation
IHE41_RS08440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IHE41_RS08445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IHE41_RS08455	COG0544	peptidyl-prolyl cis-trans isomerase activity
IHE41_RS08470	COG2204	response regulator
IHE41_RS08480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IHE41_RS08485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IHE41_RS08490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IHE41_RS08495	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IHE41_RS08510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IHE41_RS08515	COG0569	domain protein
IHE41_RS08520	COG0513	Belongs to the DEAD box helicase family
IHE41_RS08525	COG1253	flavin adenine dinucleotide binding
IHE41_RS08560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IHE41_RS08565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IHE41_RS08580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IHE41_RS08585	COG1216	Glycosyl transferase, family 2
IHE41_RS08590	COG2986	histidine ammonia-lyase
IHE41_RS08615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IHE41_RS08625	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS08675	COG0582	viral genome integration into host DNA
IHE41_RS08685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IHE41_RS08690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IHE41_RS08695	COG0583	DNA-binding transcription factor activity
IHE41_RS08700	COG2951	lytic endotransglycosylase activity
IHE41_RS08705	COG3100	YcgL domain-containing protein
IHE41_RS08710	COG0850	regulation of cytokinetic process
IHE41_RS08715	COG2894	cell division
IHE41_RS08720	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IHE41_RS08725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IHE41_RS08730	COG0318	PFAM AMP-dependent synthetase and ligase
IHE41_RS08735	COG2267	carboxylic ester hydrolase activity
IHE41_RS08750	COG1214	PFAM Peptidase M22, glycoprotease
IHE41_RS08755	COG1199	ATP-dependent helicase activity
IHE41_RS08760	COG0788	formyltetrahydrofolate deformylase activity
IHE41_RS08765	COG3102	Protein conserved in bacteria
IHE41_RS08770	COG0018	arginyl-trna synthetase
IHE41_RS08790	COG1918	ferrous iron import across plasma membrane
IHE41_RS08795	COG4977	sequence-specific DNA binding
IHE41_RS08800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IHE41_RS08805	COG1121	(ABC) transporter
IHE41_RS08810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IHE41_RS08820	COG0045	succinate-CoA ligase (ADP-forming) activity
IHE41_RS08825	COG0508	dehydrogenase complex catalyzes the overall conversion of
IHE41_RS08830	COG0567	Dehydrogenase, E1 component
IHE41_RS08835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IHE41_RS08840	COG1053	succinate dehydrogenase
IHE41_RS08845	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IHE41_RS08860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IHE41_RS08870	COG0033	Phosphoglucomutase
IHE41_RS08875	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IHE41_RS08880	COG0596	Alpha beta hydrolase
IHE41_RS08900	COG0735	belongs to the Fur family
IHE41_RS08905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IHE41_RS08910	COG1263	PTS System
IHE41_RS08910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHE41_RS08915	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IHE41_RS08920	COG1940	carbohydrate kinase activity
IHE41_RS08920	COG1846	Transcriptional regulator
IHE41_RS08925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IHE41_RS08925	COG4651	solute:proton antiporter activity
IHE41_RS08930	COG0367	asparagine synthase
IHE41_RS08935	COG0250	Participates in transcription elongation, termination and antitermination
IHE41_RS08940	COG3104	oligopeptide transport
IHE41_RS08945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IHE41_RS08950	COG0563	adenylate kinase activity
IHE41_RS08955	COG0326	Molecular chaperone. Has ATPase activity
IHE41_RS08960	COG3710	Transcriptional regulator
IHE41_RS08980	COG0622	Phosphoesterase
IHE41_RS09010	COG1090	epimerase
IHE41_RS09015	COG0300	oxidoreductase activity
IHE41_RS09020	COG3118	belongs to the thioredoxin family
IHE41_RS09025	COG0330	HflC and HflK could
IHE41_RS09045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IHE41_RS09050	COG3115	cell septum assembly
IHE41_RS09055	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IHE41_RS09060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IHE41_RS09065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHE41_RS09070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IHE41_RS09075	COG2190	(PTS) system
IHE41_RS09080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS09085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS09090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS09095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS09105	COG3951	Flagellar rod assembly protein muramidase FlgJ
IHE41_RS09105	COG1705	Flagellar rod assembly protein muramidase FlgJ
IHE41_RS09110	COG1706	bacterial-type flagellum-dependent cell motility
IHE41_RS09115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IHE41_RS09125	COG4787	bacterial-type flagellum-dependent cell motility
IHE41_RS09130	COG1749	Flagellar hook protein flgE
IHE41_RS09140	COG1558	bacterial-type flagellum-dependent cell motility
IHE41_RS09145	COG1815	bacterial-type flagellum-dependent cell motility
IHE41_RS09150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IHE41_RS09155	COG0835	chemotaxis
IHE41_RS09155	COG0784	Response regulator, receiver
IHE41_RS09205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IHE41_RS09210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IHE41_RS09220	COG2608	mercury ion transmembrane transporter activity
IHE41_RS09220	COG2217	Heavy metal translocating P-type atpase
IHE41_RS09255	COG2840	Smr protein MutS2
IHE41_RS09260	COG1187	pseudouridine synthase activity
IHE41_RS09270	COG0737	Belongs to the 5'-nucleotidase family
IHE41_RS09275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IHE41_RS09280	COG2912	Transglutaminase-like superfamily
IHE41_RS09285	COG3094	Invasion gene expression up-regulator, SirB
IHE41_RS09290	COG2890	protein-(glutamine-N5) methyltransferase activity
IHE41_RS09295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IHE41_RS09300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IHE41_RS09305	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IHE41_RS09310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IHE41_RS09315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IHE41_RS09320	COG0193	aminoacyl-tRNA hydrolase activity
IHE41_RS09325	COG0012	GTP binding
IHE41_RS09440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IHE41_RS09445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IHE41_RS09450	COG1702	phosphate starvation-inducible protein PhoH
IHE41_RS09455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IHE41_RS09460	COG4535	Mg2 and Co2 transporter CorC
IHE41_RS09465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IHE41_RS09470	COG2888	peptidyl-tyrosine sulfation
IHE41_RS09475	COG0495	leucyl-tRNA aminoacylation
IHE41_RS09480	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IHE41_RS09485	COG1466	dna polymerase III delta subunit
IHE41_RS09490	COG0799	negative regulation of ribosome biogenesis
IHE41_RS09495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IHE41_RS09500	COG0768	penicillin binding
IHE41_RS09505	COG0772	Belongs to the SEDS family
IHE41_RS09510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IHE41_RS09515	COG1686	Belongs to the peptidase S11 family
IHE41_RS09520	COG2921	Belongs to the UPF0250 family
IHE41_RS09525	COG0321	lipoyl(octanoyl) transferase activity
IHE41_RS09530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IHE41_RS09535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IHE41_RS09540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHE41_RS09555	COG0366	Alpha amylase catalytic
IHE41_RS09560	COG1263	PTS System
IHE41_RS09560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHE41_RS09570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IHE41_RS09575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IHE41_RS09580	COG2011	ABC-type metal ion transport system permease component
IHE41_RS09585	COG1464	Belongs to the NlpA lipoprotein family
IHE41_RS09590	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IHE41_RS09600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IHE41_RS09600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IHE41_RS09615	COG1611	Belongs to the LOG family
IHE41_RS09620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IHE41_RS09630	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IHE41_RS09635	COG2363	Small membrane protein
IHE41_RS09645	COG0583	DNA-binding transcription factor activity
IHE41_RS09650	COG0301	tRNA thio-modification
IHE41_RS09650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IHE41_RS09655	COG2885	chlorophyll binding
IHE41_RS09660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IHE41_RS09665	COG1722	exodeoxyribonuclease VII activity
IHE41_RS09670	COG0142	geranyltranstransferase activity
IHE41_RS09675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IHE41_RS09680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IHE41_RS09685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IHE41_RS09690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IHE41_RS09710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IHE41_RS09710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IHE41_RS09715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IHE41_RS09720	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IHE41_RS09725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IHE41_RS09735	COG1073	alpha beta
IHE41_RS09740	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IHE41_RS09745	COG2252	PERMEase
IHE41_RS09750	COG2195	Cleaves the N-terminal amino acid of tripeptides
IHE41_RS09775	COG0047	phosphoribosylformylglycinamidine synthase activity
IHE41_RS09775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IHE41_RS09780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IHE41_RS09795	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IHE41_RS09825	COG0484	heat shock protein binding
IHE41_RS09830	COG0443	Heat shock 70 kDa protein
IHE41_RS09840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IHE41_RS09845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IHE41_RS09855	COG0497	DNA recombination
IHE41_RS09860	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IHE41_RS09865	COG2914	Belongs to the UPF0125 (RnfH) family
IHE41_RS09870	COG2867	negative regulation of translational initiation
IHE41_RS09875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IHE41_RS09900	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IHE41_RS09935	COG0583	DNA-binding transcription factor activity
IHE41_RS09940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IHE41_RS09940	COG3153	acetyltransferase
IHE41_RS09960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IHE41_RS09965	COG2873	o-acetylhomoserine
IHE41_RS09995	COG1115	amino acid carrier protein
IHE41_RS10005	COG1584	GPR1 FUN34 yaaH family protein
IHE41_RS10015	COG1757	Na H antiporter
IHE41_RS10020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IHE41_RS10020	COG0519	Catalyzes the synthesis of GMP from XMP
IHE41_RS10025	COG0517	IMP dehydrogenase activity
IHE41_RS10025	COG0516	GMP reductase activity
IHE41_RS10030	COG1570	exodeoxyribonuclease VII activity
IHE41_RS10045	COG1160	GTP binding
IHE41_RS10050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IHE41_RS10055	COG2976	Protein conserved in bacteria
IHE41_RS10060	COG0124	histidyl-tRNA synthetase
IHE41_RS10065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IHE41_RS10075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IHE41_RS10080	COG0105	UTP biosynthetic process
IHE41_RS10085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IHE41_RS10090	COG2975	iron-sulfur cluster assembly
IHE41_RS10095	COG0633	Ferredoxin
IHE41_RS10100	COG0443	Heat shock 70 kDa protein
IHE41_RS10105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IHE41_RS10115	COG0822	iron-sulfur transferase activity
IHE41_RS10120	COG1104	cysteine desulfurase activity
IHE41_RS10135	COG0483	inositol monophosphate 1-phosphatase activity
IHE41_RS10140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IHE41_RS10145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IHE41_RS10150	COG1862	Preprotein translocase
IHE41_RS10155	COG0343	queuine tRNA-ribosyltransferase activity
IHE41_RS10160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IHE41_RS10170	COG0517	IMP dehydrogenase activity
IHE41_RS10180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IHE41_RS10185	COG0583	DNA-binding transcription factor activity
IHE41_RS10190	COG0450	alkyl hydroperoxide reductase
IHE41_RS10195	COG3142	Participates in the control of copper homeostasis
IHE41_RS10205	COG0704	Plays a role in the regulation of phosphate uptake
IHE41_RS10210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IHE41_RS10215	COG0581	inorganic phosphate transmembrane transporter activity
IHE41_RS10225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IHE41_RS10230	COG0248	Ppx GppA phosphatase
IHE41_RS10240	COG5002	protein histidine kinase activity
IHE41_RS10245	COG0745	RESPONSE REGULATOR receiver
IHE41_RS10250	COG2974	May be involved in recombination
IHE41_RS10255	COG0826	peptidase U32
IHE41_RS10260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IHE41_RS10315	COG0542	response to heat
IHE41_RS10325	COG0564	pseudouridine synthase activity
IHE41_RS10330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IHE41_RS10335	COG0741	lytic transglycosylase activity
IHE41_RS10340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IHE41_RS10345	COG1605	Chorismate mutase
IHE41_RS10345	COG0077	Prephenate dehydratase
IHE41_RS10350	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IHE41_RS10355	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IHE41_RS10365	COG0488	(ABC) transporter
IHE41_RS10375	COG0739	heme binding
IHE41_RS10380	COG0287	Prephenate dehydrogenase
IHE41_RS10380	COG1605	Chorismate mutase
IHE41_RS10385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IHE41_RS10390	COG1472	Belongs to the glycosyl hydrolase 3 family
IHE41_RS10395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IHE41_RS10400	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IHE41_RS10415	COG1966	Carbon starvation protein
IHE41_RS10420	COG3275	phosphorelay sensor kinase activity
IHE41_RS10425	COG3279	Response regulator of the LytR AlgR family
IHE41_RS10430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IHE41_RS10435	COG1047	Peptidyl-prolyl cis-trans
IHE41_RS10440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IHE41_RS10445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IHE41_RS10450	COG0196	riboflavin kinase activity
IHE41_RS10455	COG0728	peptidoglycan biosynthetic process
IHE41_RS10460	COG0268	Binds directly to 16S ribosomal RNA
IHE41_RS10465	COG0640	Transcriptional regulator
IHE41_RS10470	COG0583	DNA-binding transcription factor activity
IHE41_RS10475	COG1283	sodium-dependent phosphate transmembrane transporter activity
IHE41_RS10485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IHE41_RS10490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IHE41_RS10495	COG0730	response to heat
IHE41_RS10505	COG0494	nUDIX hydrolase
IHE41_RS10510	COG3066	DNA modification
IHE41_RS10520	COG0667	Aldo Keto reductase
IHE41_RS10535	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IHE41_RS10545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IHE41_RS10550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IHE41_RS10555	COG4974	Belongs to the 'phage' integrase family
IHE41_RS10560	COG0716	FMN binding
IHE41_RS10570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IHE41_RS10575	COG0513	Belongs to the DEAD box helicase family
IHE41_RS10580	COG3022	response to hydroperoxide
IHE41_RS10585	COG1115	amino acid carrier protein
IHE41_RS10600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IHE41_RS10605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IHE41_RS10610	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IHE41_RS10615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IHE41_RS10620	COG0083	homoserine kinase activity
IHE41_RS10635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IHE41_RS10645	COG0745	RESPONSE REGULATOR receiver
IHE41_RS10655	COG0784	Response regulator, receiver
IHE41_RS10655	COG2198	Histidine kinase
IHE41_RS10655	COG5002	protein histidine kinase activity
IHE41_RS10660	COG5001	Diguanylate cyclase
IHE41_RS10660	COG4251	negative regulation of phosphorylation
IHE41_RS10660	COG3706	GGDEF domain
IHE41_RS10660	COG2203	Gaf domain
IHE41_RS10665	COG1242	4 iron, 4 sulfur cluster binding
IHE41_RS10670	COG0067	glutamate synthase
IHE41_RS10670	COG0069	glutamate synthase activity
IHE41_RS10670	COG0070	glutamate synthase
IHE41_RS10680	COG0070	glutamate synthase
IHE41_RS10680	COG0067	glutamate synthase
IHE41_RS10680	COG0069	glutamate synthase activity
IHE41_RS10685	COG0493	'glutamate synthase
IHE41_RS10695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IHE41_RS10705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IHE41_RS10710	COG2860	membrane
IHE41_RS10715	COG0583	DNA-binding transcription factor activity
IHE41_RS10720	COG0730	response to heat
IHE41_RS10730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IHE41_RS10735	COG0505	Belongs to the CarA family
IHE41_RS10740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IHE41_RS10745	COG0494	nUDIX hydrolase
IHE41_RS10750	COG0653	protein targeting
IHE41_RS10760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IHE41_RS10765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IHE41_RS10770	COG0849	cell division
IHE41_RS10775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IHE41_RS10780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IHE41_RS10785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IHE41_RS10790	COG0772	Belongs to the SEDS family
IHE41_RS10795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IHE41_RS10800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IHE41_RS10805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IHE41_RS10810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IHE41_RS10815	COG0768	penicillin binding
IHE41_RS10820	COG3116	cell division
IHE41_RS10825	COG0275	rRNA processing
IHE41_RS10835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IHE41_RS10845	COG0792	nuclease activity
IHE41_RS10850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IHE41_RS10855	COG2823	Periplasmic or secreted lipoprotein
IHE41_RS10860	COG2969	positive regulation of protein catabolic process
IHE41_RS10865	COG0625	glutathione transferase activity
IHE41_RS10870	COG2857	Cytochrome c1
IHE41_RS10875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IHE41_RS10880	COG0723	plastoquinol--plastocyanin reductase activity
IHE41_RS10885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IHE41_RS10890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IHE41_RS10895	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IHE41_RS10900	COG3105	Protein conserved in bacteria
IHE41_RS10910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IHE41_RS10915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IHE41_RS10925	COG3150	esterase
IHE41_RS10935	COG3151	Protein conserved in bacteria
IHE41_RS10940	COG0494	nUDIX hydrolase
IHE41_RS10945	COG1538	Outer membrane efflux protein
IHE41_RS10950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IHE41_RS10950	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IHE41_RS10955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IHE41_RS10970	COG3025	triphosphatase activity
IHE41_RS10975	COG1392	Phosphate transport regulator
IHE41_RS10980	COG0306	phosphate transporter
IHE41_RS10985	COG4991	sh3 domain protein
IHE41_RS10995	COG3409	Peptidoglycan-binding domain 1 protein
IHE41_RS10995	COG3267	Type II secretory pathway component ExeA
IHE41_RS11000	COG0617	tRNA 3'-terminal CCA addition
IHE41_RS11005	COG1968	undecaprenyl-diphosphatase activity
IHE41_RS11010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IHE41_RS11015	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IHE41_RS11020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IHE41_RS11025	COG0596	Alpha beta hydrolase
IHE41_RS11030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IHE41_RS11035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IHE41_RS11040	COG1610	YqeY-like protein
IHE41_RS11045	COG0358	DNA primase activity
IHE41_RS11060	COG1464	Belongs to the NlpA lipoprotein family
IHE41_RS11090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHE41_RS11090	COG2213	PTS system mannitol-specific
IHE41_RS11095	COG0246	Mannitol dehydrogenase
IHE41_RS11100	COG3722	fumarate hydratase activity
IHE41_RS11105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IHE41_RS11110	COG5002	protein histidine kinase activity
IHE41_RS11125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IHE41_RS11130	COG1349	DNA-binding transcription factor activity
IHE41_RS11135	COG0469	pyruvate kinase activity
IHE41_RS11150	COG0440	acetolactate synthase activity
IHE41_RS11155	COG0028	Belongs to the TPP enzyme family
IHE41_RS11160	COG1022	Amp-dependent synthetase and ligase
IHE41_RS11165	COG0583	DNA-binding transcription factor activity
IHE41_RS11185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IHE41_RS11190	COG0473	3-isopropylmalate dehydrogenase activity
IHE41_RS11195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IHE41_RS11200	COG0066	3-isopropylmalate dehydratase activity
IHE41_RS11210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IHE41_RS11215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IHE41_RS11220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IHE41_RS11225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IHE41_RS11230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IHE41_RS11235	COG2967	ApaG domain
IHE41_RS11240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IHE41_RS11255	COG2966	Psort location CytoplasmicMembrane, score
IHE41_RS11260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IHE41_RS11270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IHE41_RS11275	COG0142	geranyltranstransferase activity
IHE41_RS11285	COG0039	L-malate dehydrogenase activity
IHE41_RS11295	COG2358	TRAP transporter, solute receptor (TAXI family
IHE41_RS11310	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IHE41_RS11315	COG1178	ABC-type Fe3 transport system permease component
IHE41_RS11320	COG4143	(ABC) transporter
IHE41_RS11325	COG0163	prenyltransferase activity
IHE41_RS11330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IHE41_RS11335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IHE41_RS11340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IHE41_RS11350	COG2105	PFAM AIG2 family protein
IHE41_RS11360	COG0729	surface antigen
IHE41_RS11365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IHE41_RS11375	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IHE41_RS11390	COG4181	ATPase activity
IHE41_RS11410	COG0529	Catalyzes the synthesis of activated sulfate
IHE41_RS11415	COG0471	metal ion transport
IHE41_RS11415	COG3273	potassium ion transport
IHE41_RS11420	COG2895	sulfate adenylyltransferase (ATP) activity
IHE41_RS11425	COG0175	sulfate reduction
IHE41_RS11430	COG1648	precorrin-2 dehydrogenase activity
IHE41_RS11430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IHE41_RS11435	COG0737	Belongs to the 5'-nucleotidase family
IHE41_RS11445	COG0513	Belongs to the DEAD box helicase family
IHE41_RS11450	COG2153	protein acetylation
IHE41_RS11460	COG0545	Peptidyl-prolyl cis-trans isomerase
IHE41_RS11470	COG0203	ribosomal protein L17
IHE41_RS11475	COG0202	RNA polymerase activity
IHE41_RS11485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IHE41_RS11490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IHE41_RS11495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IHE41_RS11500	COG0201	protein transport
IHE41_RS11505	COG0200	Binds to the 23S rRNA
IHE41_RS11510	COG1841	ribosomal large subunit assembly
IHE41_RS11525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IHE41_RS11530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IHE41_RS11535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IHE41_RS11540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IHE41_RS11545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IHE41_RS11550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IHE41_RS11555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IHE41_RS11560	COG0255	Belongs to the universal ribosomal protein uL29 family
IHE41_RS11570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IHE41_RS11575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IHE41_RS11580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IHE41_RS11585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IHE41_RS11595	COG0088	Forms part of the polypeptide exit tunnel
IHE41_RS11600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IHE41_RS11610	COG0254	rRNA binding
IHE41_RS11615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IHE41_RS11620	COG1609	Transcriptional regulator
IHE41_RS11630	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IHE41_RS11635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IHE41_RS11640	COG1575	Belongs to the MenA family. Type 1 subfamily
IHE41_RS11645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IHE41_RS11650	COG3074	FtsZ-dependent cytokinesis
IHE41_RS11655	COG1494	fructose-1,6-bisphosphatase
IHE41_RS11680	COG0149	triose-phosphate isomerase activity
IHE41_RS11700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IHE41_RS11705	COG1216	Glycosyl transferase, family 2
IHE41_RS11740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IHE41_RS11775	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IHE41_RS11785	COG1560	Kdo2-lipid A biosynthetic process
IHE41_RS11790	COG0859	PFAM glycosyl transferase family 9
IHE41_RS11795	COG1519	Transferase
IHE41_RS11820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IHE41_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS11835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IHE41_RS11865	COG3642	lipopolysaccharide core region biosynthetic process
IHE41_RS11870	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IHE41_RS11875	COG0859	PFAM glycosyl transferase family 9
IHE41_RS11880	COG0463	Glycosyl transferase, family 2
IHE41_RS11895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IHE41_RS11900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IHE41_RS11915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IHE41_RS11920	COG2003	Belongs to the UPF0758 family
IHE41_RS11930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IHE41_RS11935	COG1309	transcriptional regulator
IHE41_RS11940	COG1560	Kdo2-lipid A biosynthetic process
IHE41_RS11945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IHE41_RS11950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IHE41_RS11955	COG1561	YicC-like family, N-terminal region
IHE41_RS11965	COG4608	Belongs to the ABC transporter superfamily
IHE41_RS11970	COG0444	Belongs to the ABC transporter superfamily
IHE41_RS11975	COG0747	negative chemotaxis
IHE41_RS11980	COG4239	(ABC) transporter, permease
IHE41_RS11985	COG4174	ABC transporter (Permease)
IHE41_RS12005	COG0811	peptide transport
IHE41_RS12010	COG0848	biopolymer transport protein
IHE41_RS12025	COG0194	GDP metabolic process
IHE41_RS12030	COG1758	RNA polymerase activity
IHE41_RS12035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IHE41_RS12040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IHE41_RS12045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IHE41_RS12050	COG2233	PERMEase
IHE41_RS12070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IHE41_RS12080	COG2183	response to ionizing radiation
IHE41_RS12090	COG0596	Alpha beta hydrolase
IHE41_RS12095	COG1040	competence protein
IHE41_RS12100	COG0316	Belongs to the HesB IscA family
IHE41_RS12100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IHE41_RS12105	COG0494	nUDIX hydrolase
IHE41_RS12110	COG1218	3'(2'),5'-bisphosphate nucleotidase
IHE41_RS12120	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IHE41_RS12125	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IHE41_RS12130	COG3156	type II secretion system protein K
IHE41_RS12135	COG4795	General secretion pathway protein
IHE41_RS12140	COG2165	general secretion pathway protein
IHE41_RS12145	COG2165	general secretion pathway protein
IHE41_RS12150	COG2165	general secretion pathway protein
IHE41_RS12155	COG1459	type II secretion system
IHE41_RS12160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IHE41_RS12170	COG3031	protein transport across the cell outer membrane
IHE41_RS12175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IHE41_RS12180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IHE41_RS12185	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IHE41_RS12195	COG0456	acetyltransferase
IHE41_RS12200	COG1490	D-aminoacyl-tRNA deacylase activity
IHE41_RS12205	COG1295	ribonuclease BN
IHE41_RS12220	COG1217	gtp-binding protein TYPA
IHE41_RS12225	COG0174	glutamine synthetase
IHE41_RS12235	COG3852	Histidine kinase
IHE41_RS12240	COG2204	response regulator
IHE41_RS12250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IHE41_RS12280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IHE41_RS12285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IHE41_RS12285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IHE41_RS12300	COG0084	hydrolase, TatD family'
IHE41_RS12305	COG0805	protein transport
IHE41_RS12310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IHE41_RS12315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IHE41_RS12320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IHE41_RS12325	COG3165	ubiquinone biosynthetic process from chorismate
IHE41_RS12330	COG2226	methyltransferase
IHE41_RS12335	COG1322	Protein conserved in bacteria
IHE41_RS12350	COG0628	permease
IHE41_RS12400	COG2823	Periplasmic or secreted lipoprotein
IHE41_RS12410	COG2081	HI0933 family
IHE41_RS12420	COG1528	Iron-storage protein
IHE41_RS12425	COG0589	response to stress
IHE41_RS12440	COG0742	ribosomal rna small subunit methyltransferase
IHE41_RS12445	COG5001	Diguanylate cyclase
IHE41_RS12445	COG5002	protein histidine kinase activity
IHE41_RS12450	COG1522	sequence-specific DNA binding
IHE41_RS12455	COG0339	signal peptide processing
IHE41_RS12460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IHE41_RS12465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IHE41_RS12530	COG0583	DNA-binding transcription factor activity
IHE41_RS12535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IHE41_RS12540	COG0800	Aldolase
IHE41_RS12545	COG2610	gluconate transmembrane transporter activity
IHE41_RS12550	COG3265	gluconokinase activity
IHE41_RS12555	COG0129	dihydroxy-acid dehydratase activity
IHE41_RS12570	COG0583	DNA-binding transcription factor activity
IHE41_RS12575	COG1609	Transcriptional regulator
IHE41_RS12610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IHE41_RS12615	COG0601	transmembrane transport
IHE41_RS12620	COG0747	negative chemotaxis
IHE41_RS12625	COG4172	Belongs to the ABC transporter superfamily
IHE41_RS12675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS12680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IHE41_RS12685	COG2960	long-chain fatty acid transporting porin activity
IHE41_RS12690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IHE41_RS12695	COG0583	DNA-binding transcription factor activity
IHE41_RS12730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IHE41_RS12740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IHE41_RS12745	COG0408	coproporphyrinogen oxidase activity
IHE41_RS12750	COG0009	L-threonylcarbamoyladenylate synthase
IHE41_RS12755	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IHE41_RS12760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IHE41_RS12765	COG0551	DNA topoisomerase type I activity
IHE41_RS12770	COG2922	Belongs to the Smg family
IHE41_RS12775	COG0758	DNA mediated transformation
IHE41_RS12785	COG0242	peptide deformylase activity
IHE41_RS12790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IHE41_RS12795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IHE41_RS12795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IHE41_RS12800	COG0569	domain protein
IHE41_RS12805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IHE41_RS12815	COG1272	protein, Hemolysin III
IHE41_RS12820	COG4326	sporulation control protein
IHE41_RS12825	COG3084	Protein conserved in bacteria
IHE41_RS12835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IHE41_RS12840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IHE41_RS12845	COG0204	Acyl-transferase
IHE41_RS12880	COG1196	nuclear chromosome segregation
IHE41_RS12890	COG1278	Cold shock
IHE41_RS12915	COG1278	Cold shock
IHE41_RS12925	COG0330	HflC and HflK could
IHE41_RS12945	COG1278	Cold shock
IHE41_RS12980	COG0606	chelatase, subunit chli
IHE41_RS12990	COG3978	acetolactate synthase activity
IHE41_RS12995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IHE41_RS13000	COG0129	dihydroxy-acid dehydratase activity
IHE41_RS13010	COG0583	DNA-binding transcription factor activity
IHE41_RS13015	COG2814	Major facilitator Superfamily
IHE41_RS13020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHE41_RS13025	COG0765	amino acid transport
IHE41_RS13030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IHE41_RS13035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IHE41_RS13040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IHE41_RS13045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IHE41_RS13050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IHE41_RS13055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IHE41_RS13070	COG0356	it plays a direct role in the translocation of protons across the membrane
IHE41_RS13075	COG3312	ion transport
IHE41_RS13080	COG1475	DNA binding
IHE41_RS13085	COG1192	Involved in chromosome partitioning
IHE41_RS13090	COG0357	Ribosomal RNA small subunit methyltransferase G
IHE41_RS13095	COG0445	tRNA wobble uridine modification
IHE41_RS13100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IHE41_RS13105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IHE41_RS13110	COG0706	membrane insertase activity
IHE41_RS13120	COG0594	ribonuclease P activity
IHE41_RS13130	COG1126	abc transporter atp-binding protein
IHE41_RS13145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IHE41_RS13150	COG0592	DNA-directed DNA polymerase activity
IHE41_RS13155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IHE41_RS13160	COG0187	DNA topoisomerase II activity
IHE41_RS13170	COG0071	Belongs to the small heat shock protein (HSP20) family
IHE41_RS13175	COG3977	Valine--pyruvate aminotransferase
IHE41_RS13180	COG0366	Alpha amylase catalytic
IHE41_RS13185	COG0751	glycine-tRNA ligase activity
IHE41_RS13190	COG0752	glycyl-tRNA synthetase alpha subunit
IHE41_RS13195	COG2119	membrane
IHE41_RS13205	COG0425	Belongs to the sulfur carrier protein TusA family
IHE41_RS13220	COG0604	alcohol dehydrogenase
IHE41_RS13225	COG0183	Belongs to the thiolase family
IHE41_RS13230	COG1024	Enoyl-CoA hydratase
IHE41_RS13230	COG1250	3-hydroxyacyl-CoA dehydrogenase
IHE41_RS13235	COG1739	Uncharacterized protein family UPF0029
IHE41_RS13240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IHE41_RS13290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IHE41_RS13295	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IHE41_RS13300	COG0352	thiamine-phosphate diphosphorylase activity
IHE41_RS13305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IHE41_RS13310	COG2104	thiamine diphosphate biosynthetic process
IHE41_RS13315	COG2022	thiamine diphosphate biosynthetic process
IHE41_RS13325	COG0006	proline dipeptidase activity
IHE41_RS13325	COG0006	proline dipeptidase activity
IHE41_RS13355	COG3220	belongs to the UPF0276 family
IHE41_RS13365	COG0210	DNA helicase
IHE41_RS13370	COG0405	Gamma-glutamyltransferase
IHE41_RS13375	COG1280	lysine exporter protein (LysE YggA)
IHE41_RS13385	COG2962	Rard protein
IHE41_RS13390	COG0514	ATP-dependent DNA helicase (RecQ)
IHE41_RS13400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IHE41_RS13405	COG0248	Ppx GppA phosphatase
IHE41_RS13410	COG0513	Belongs to the DEAD box helicase family
IHE41_RS13415	COG3118	belongs to the thioredoxin family
IHE41_RS13430	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IHE41_RS13435	COG0633	Ferredoxin
IHE41_RS13480	COG3071	HemY protein
IHE41_RS13485	COG2959	enzyme of heme biosynthesis
IHE41_RS13490	COG1587	Uroporphyrinogen-III synthase
IHE41_RS13495	COG0181	hydroxymethylbilane synthase activity
IHE41_RS13500	COG3072	Adenylate cyclase
IHE41_RS13505	COG1965	Belongs to the frataxin family
IHE41_RS13515	COG0019	diaminopimelate decarboxylase activity
IHE41_RS13520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IHE41_RS13530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IHE41_RS13535	COG1011	Hydrolase
IHE41_RS13540	COG3287	FIST C domain
IHE41_RS13540	COG2199	diguanylate cyclase activity
IHE41_RS13540	COG2200	EAL domain
IHE41_RS13545	COG3148	PFAM DTW domain containing protein
IHE41_RS13560	COG0561	phosphatase activity
IHE41_RS13565	COG2267	carboxylic ester hydrolase activity
IHE41_RS13570	COG1280	lysine exporter protein (LysE YggA)
IHE41_RS13575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IHE41_RS13580	COG0640	Transcriptional regulator
IHE41_RS13585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IHE41_RS13635	COG2095	MarC family integral membrane protein
IHE41_RS13645	COG0742	ribosomal rna small subunit methyltransferase
IHE41_RS13650	COG0552	protein localization to endoplasmic reticulum
IHE41_RS13655	COG2884	Cell division ATP-binding protein ftsE
IHE41_RS13660	COG2177	Part of the ABC transporter FtsEX involved in
IHE41_RS13670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IHE41_RS13675	COG0705	Rhomboid family
IHE41_RS13680	COG1580	Controls the rotational direction of flagella during chemotaxis
IHE41_RS13685	COG3161	chorismate lyase activity
IHE41_RS13690	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IHE41_RS13695	COG2937	Belongs to the GPAT DAPAT family
IHE41_RS13700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IHE41_RS13705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IHE41_RS13710	COG0534	Mate efflux family protein
IHE41_RS13715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IHE41_RS13730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IHE41_RS13735	COG4206	TonB-dependent receptor
IHE41_RS13745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IHE41_RS13810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IHE41_RS13820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IHE41_RS13855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IHE41_RS13860	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IHE41_RS13865	COG0250	Participates in transcription elongation, termination and antitermination
IHE41_RS13870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IHE41_RS13875	COG0081	regulation of translation
IHE41_RS13880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IHE41_RS13885	COG0222	ribosome binding
IHE41_RS13890	COG0085	RNA polymerase activity
IHE41_RS13895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IHE41_RS13900	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IHE41_RS13905	COG2816	NAD+ diphosphatase activity
IHE41_RS13920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IHE41_RS13925	COG1573	uracil-dna glycosylase
IHE41_RS13930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IHE41_RS13940	COG1253	flavin adenine dinucleotide binding
IHE41_RS13955	COG0151	Belongs to the GarS family
IHE41_RS13960	COG0138	bifunctional purine biosynthesis protein purh
IHE41_RS13965	COG0789	Transcriptional regulator
IHE41_RS13970	COG3710	Transcriptional regulator
IHE41_RS13975	COG0531	amino acid
IHE41_RS13980	COG1982	Orn Lys Arg decarboxylase major
IHE41_RS14035	COG3706	GGDEF domain
IHE41_RS14040	COG0488	(ABC) transporter
IHE41_RS14045	COG2814	Major facilitator Superfamily
IHE41_RS14050	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IHE41_RS14055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IHE41_RS14060	COG2264	protein methyltransferase activity
IHE41_RS14065	COG0439	Biotin carboxylase
IHE41_RS14070	COG0511	ligase activity, forming carbon-carbon bonds
IHE41_RS14075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IHE41_RS14080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IHE41_RS14095	COG2814	Major facilitator Superfamily
IHE41_RS14100	COG2205	protein histidine kinase activity
IHE41_RS14100	COG2198	Histidine kinase
IHE41_RS14100	COG0784	Response regulator, receiver
IHE41_RS14120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IHE41_RS14130	COG3263	regulation of cellular component size
IHE41_RS14140	COG4232	protein-disulfide reductase activity
IHE41_RS14145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IHE41_RS14150	COG1027	Aspartate ammonia-lyase
IHE41_RS14155	COG3030	protein affecting phage T7 exclusion by the F plasmid
IHE41_RS14160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IHE41_RS14170	COG2205	protein histidine kinase activity
IHE41_RS14175	COG0745	RESPONSE REGULATOR receiver
IHE41_RS14180	COG3678	ATP-independent chaperone mediated protein folding
IHE41_RS14190	COG0205	6-phosphofructokinase activity
IHE41_RS14195	COG0534	Mate efflux family protein
IHE41_RS14205	COG0459	protein refolding
IHE41_RS14220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IHE41_RS14225	COG1509	lysine 2,3-aminomutase activity
IHE41_RS14230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IHE41_RS14240	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IHE41_RS14245	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IHE41_RS14250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IHE41_RS14255	COG1053	succinate dehydrogenase
IHE41_RS14260	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IHE41_RS14280	COG4942	peptidase
IHE41_RS14285	COG1045	serine acetyltransferase
IHE41_RS14290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IHE41_RS14295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IHE41_RS14300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IHE41_RS14305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IHE41_RS14320	COG0471	metal ion transport
IHE41_RS14325	COG0688	phosphatidylethanolamine metabolic process
IHE41_RS14330	COG1162	GTPase activity
IHE41_RS14335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IHE41_RS14405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IHE41_RS14410	COG0802	atpase or kinase
IHE41_RS14420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IHE41_RS14425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IHE41_RS14435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IHE41_RS14440	COG0330	HflC and HflK could
IHE41_RS14445	COG0330	HflC and HflK could
IHE41_RS14450	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IHE41_RS14455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IHE41_RS14460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IHE41_RS14465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IHE41_RS14465	COG1017	nitric oxide dioxygenase activity
IHE41_RS14470	COG1959	2 iron, 2 sulfur cluster binding
IHE41_RS14475	COG0557	exoribonuclease II activity
IHE41_RS14480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IHE41_RS14485	COG0546	phosphoglycolate phosphatase activity
IHE41_RS14490	COG0180	Tryptophanyl-tRNA synthetase
IHE41_RS14505	COG0512	Glutamine amidotransferase of anthranilate synthase
IHE41_RS14510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IHE41_RS14520	COG1012	belongs to the aldehyde dehydrogenase family
IHE41_RS14530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IHE41_RS14535	COG3954	Phosphoribulokinase
IHE41_RS14540	COG3089	Belongs to the UPF0270 family
IHE41_RS14545	COG0429	hydrolase of the alpha beta-hydrolase fold
IHE41_RS14555	COG0488	(ABC) transporter
IHE41_RS14560	COG2249	NAD(P)H dehydrogenase (quinone) activity
IHE41_RS14575	COG1047	Peptidyl-prolyl cis-trans
IHE41_RS14580	COG1446	asparaginase
IHE41_RS14585	COG2900	Belongs to the SlyX family
IHE41_RS14595	COG0545	Peptidyl-prolyl cis-trans isomerase
IHE41_RS14600	COG2964	Protein conserved in bacteria
IHE41_RS14605	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IHE41_RS14610	COG2923	Belongs to the DsrF TusC family
IHE41_RS14625	COG0049	tRNA binding
IHE41_RS14630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IHE41_RS14635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IHE41_RS14640	COG2906	2 iron, 2 sulfur cluster binding
IHE41_RS14650	COG0281	malic enzyme
IHE41_RS14660	COG0626	cystathionine gamma-synthase activity
IHE41_RS14665	COG0460	homoserine dehydrogenase
IHE41_RS14665	COG0527	aspartate kinase activity
IHE41_RS14670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IHE41_RS14680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IHE41_RS14685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IHE41_RS14690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IHE41_RS14695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IHE41_RS14700	COG0137	argininosuccinate synthase activity
IHE41_RS14705	COG0165	Argininosuccinate lyase
IHE41_RS14705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IHE41_RS14715	COG0678	peroxiredoxin activity
IHE41_RS14715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IHE41_RS14725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IHE41_RS14755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IHE41_RS14760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IHE41_RS14770	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IHE41_RS14775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IHE41_RS14780	COG0360	Binds together with S18 to 16S ribosomal RNA
IHE41_RS14785	COG2965	DNA replication, synthesis of RNA primer
IHE41_RS14795	COG0359	binds to the 23S rRNA
IHE41_RS14810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IHE41_RS14820	COG0432	Pfam Uncharacterised protein family UPF0047
IHE41_RS14825	COG0166	Belongs to the GPI family
IHE41_RS14835	COG0735	belongs to the Fur family
IHE41_RS14840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IHE41_RS14860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IHE41_RS14865	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IHE41_RS14870	COG0175	sulfate reduction
IHE41_RS14935	COG0646	methionine synthase
IHE41_RS14935	COG1410	methionine synthase
IHE41_RS14940	COG0527	aspartate kinase activity
IHE41_RS14945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IHE41_RS14955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IHE41_RS14970	COG0629	single-stranded DNA binding
IHE41_RS14975	COG2200	EAL domain
IHE41_RS14975	COG2199	diguanylate cyclase activity
IHE41_RS15000	COG3267	Type II secretory pathway component ExeA
IHE41_RS15000	COG3409	Peptidoglycan-binding domain 1 protein
IHE41_RS15010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IHE41_RS15015	COG1459	type II secretion system
IHE41_RS15060	COG1077	Cell shape determining protein MreB Mrl
IHE41_RS15065	COG1792	Involved in formation and maintenance of cell shape
IHE41_RS15070	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IHE41_RS15075	COG0424	maF-like protein
IHE41_RS15085	COG3164	Protein of unknown function
IHE41_RS15090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IHE41_RS15095	COG0312	modulator of DNA gyrase
IHE41_RS15100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IHE41_RS15105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IHE41_RS15115	COG0564	pseudouridine synthase activity
IHE41_RS15120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IHE41_RS15125	COG3028	Belongs to the UPF0307 family
IHE41_RS15130	COG0312	modulator of DNA gyrase
IHE41_RS15135	COG2239	Acts as a magnesium transporter
IHE41_RS15140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHE41_RS15145	COG1660	Displays ATPase and GTPase activities
IHE41_RS15150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHE41_RS15155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IHE41_RS15165	COG1137	ATPase activity
IHE41_RS15170	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IHE41_RS15180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IHE41_RS15180	COG0517	IMP dehydrogenase activity
IHE41_RS15190	COG1127	ABC transporter
IHE41_RS15195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IHE41_RS15200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IHE41_RS15205	COG2854	intermembrane phospholipid transfer
IHE41_RS15215	COG5007	Belongs to the BolA IbaG family
IHE41_RS15220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IHE41_RS15225	COG0204	Acyl-transferase
IHE41_RS15230	COG0251	oxidation-reduction process
IHE41_RS15235	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IHE41_RS15240	COG0540	Belongs to the ATCase OTCase family
IHE41_RS15250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IHE41_RS15255	COG2235	arginine
IHE41_RS15280	COG0525	valine-tRNA ligase activity
IHE41_RS15285	COG2927	DNA polymerase III (CHI subunit)
IHE41_RS15290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IHE41_RS15295	COG0795	lipopolysaccharide-transporting ATPase activity
IHE41_RS15300	COG0795	lipopolysaccharide-transporting ATPase activity
IHE41_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS15325	COG0726	polysaccharide deacetylase
IHE41_RS15330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IHE41_RS15335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IHE41_RS15340	COG1447	Phosphotransferase system cellobiose-specific component IIA
IHE41_RS15345	COG1486	melibiose metabolic process
IHE41_RS15350	COG3394	polysaccharide catabolic process
IHE41_RS15360	COG3437	response regulator, receiver
IHE41_RS15405	COG1012	belongs to the aldehyde dehydrogenase family
IHE41_RS15475	COG0741	lytic transglycosylase activity
IHE41_RS15480	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IHE41_RS15490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IHE41_RS15500	COG2066	Belongs to the glutaminase family
IHE41_RS15505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IHE41_RS15510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IHE41_RS15520	COG1872	DUF167
IHE41_RS15525	COG0762	integral membrane protein
IHE41_RS15530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IHE41_RS15535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IHE41_RS15550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IHE41_RS15555	COG1678	Uncharacterized ACR, COG1678
IHE41_RS15560	COG0189	ligase activity
IHE41_RS15565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IHE41_RS15570	COG2356	endonuclease I
IHE41_RS15575	COG3091	SprT-like family
IHE41_RS15585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IHE41_RS15590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IHE41_RS15595	COG0583	DNA-binding transcription factor activity
IHE41_RS15600	COG4771	TonB-dependent receptor
IHE41_RS15605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IHE41_RS15610	COG0126	phosphoglycerate kinase activity
IHE41_RS15615	COG0191	fructose-bisphosphate aldolase activity
IHE41_RS15620	COG0668	transmembrane transport
IHE41_RS15625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IHE41_RS15635	COG0583	DNA-binding transcription factor activity
IHE41_RS15645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IHE41_RS15650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IHE41_RS15655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IHE41_RS15665	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IHE41_RS15670	COG3079	Belongs to the UPF0149 family
IHE41_RS15675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IHE41_RS15680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IHE41_RS15695	COG0354	folic acid binding
IHE41_RS15700	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IHE41_RS15705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IHE41_RS15710	COG1595	DNA-templated transcription, initiation
IHE41_RS15715	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IHE41_RS15725	COG3086	response to oxidative stress
IHE41_RS15730	COG0481	GTPase activity
IHE41_RS15740	COG0571	ribonuclease III activity
IHE41_RS15745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IHE41_RS15750	COG1381	Involved in DNA repair and RecF pathway recombination
IHE41_RS15755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IHE41_RS15760	COG0736	holo-[acyl-carrier-protein] synthase activity
IHE41_RS15770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IHE41_RS15775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IHE41_RS15780	COG3956	TIGRFAM MazG family protein
IHE41_RS15785	COG0504	CTP synthase activity
IHE41_RS15790	COG0148	phosphopyruvate hydratase activity
IHE41_RS15795	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IHE41_RS15800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IHE41_RS15805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IHE41_RS15810	COG0585	pseudouridine synthase activity
IHE41_RS15815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IHE41_RS15820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IHE41_RS15830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IHE41_RS15835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IHE41_RS15840	COG1546	Belongs to the CinA family
IHE41_RS15890	COG1901	pseudouridine methyltransferase
IHE41_RS15895	COG0312	modulator of DNA gyrase
IHE41_RS15900	COG0312	modulator of DNA gyrase
IHE41_RS15905	COG0351	phosphomethylpyrimidine kinase
IHE41_RS15910	COG1116	anion transmembrane transporter activity
IHE41_RS15915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IHE41_RS15920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IHE41_RS15925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IHE41_RS15930	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IHE41_RS15935	COG0352	thiamine-phosphate diphosphorylase activity
IHE41_RS15945	COG0243	molybdopterin cofactor binding
IHE41_RS15950	COG3005	denitrification pathway
IHE41_RS15960	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS15975	COG0456	acetyltransferase
IHE41_RS15995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHE41_RS16000	COG1929	Belongs to the glycerate kinase type-1 family
IHE41_RS16005	COG2610	gluconate transmembrane transporter activity
IHE41_RS16010	COG3835	regulator
IHE41_RS16035	COG0546	phosphoglycolate phosphatase activity
IHE41_RS16050	COG0583	DNA-binding transcription factor activity
IHE41_RS16060	COG0583	DNA-binding transcription factor activity
IHE41_RS16070	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IHE41_RS16075	COG3408	Glycogen debranching enzyme
IHE41_RS16075	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IHE41_RS16105	COG3047	cAMP biosynthetic process
IHE41_RS16110	COG1357	PFAM Pentapeptide repeats (8 copies)
IHE41_RS16140	COG2375	cellular response to nickel ion
IHE41_RS16145	COG0823	Involved in the tonB-independent uptake of proteins
IHE41_RS16150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IHE41_RS16170	COG0800	Aldolase
IHE41_RS16175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHE41_RS16190	COG1917	Cupin 2, conserved barrel domain protein
IHE41_RS16200	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS16205	COG1414	Transcriptional regulator
IHE41_RS16220	COG0583	DNA-binding transcription factor activity
IHE41_RS16225	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IHE41_RS16230	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IHE41_RS16245	COG2199	diguanylate cyclase activity
IHE41_RS16255	COG0561	phosphatase activity
IHE41_RS16260	COG0583	DNA-binding transcription factor activity
IHE41_RS16275	COG0564	pseudouridine synthase activity
IHE41_RS16280	COG0534	Mate efflux family protein
IHE41_RS16285	COG5001	Diguanylate cyclase
IHE41_RS16295	COG3123	guanosine phosphorylase activity
IHE41_RS16335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHE41_RS16345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IHE41_RS16350	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IHE41_RS16360	COG2259	Doxx family
IHE41_RS16365	COG1741	Belongs to the pirin family
IHE41_RS16385	COG0363	glucosamine-6-phosphate deaminase activity
IHE41_RS16395	COG0786	glutamate:sodium symporter activity
IHE41_RS16400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHE41_RS16405	COG1131	(ABC) transporter
IHE41_RS16415	COG0786	glutamate:sodium symporter activity
IHE41_RS16440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IHE41_RS16450	COG3279	Response regulator of the LytR AlgR family
IHE41_RS16455	COG3275	phosphorelay sensor kinase activity
IHE41_RS16485	COG0772	Belongs to the SEDS family
IHE41_RS16490	COG0217	transcriptional regulatory protein
IHE41_RS16510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IHE41_RS16510	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
IHE41_RS16520	COG0444	Belongs to the ABC transporter superfamily
IHE41_RS16525	COG4608	Belongs to the ABC transporter superfamily
IHE41_RS16550	COG1444	tRNA N-acetyltransferase activity
IHE41_RS16570	COG3340	Belongs to the peptidase S51 family
IHE41_RS16575	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IHE41_RS16580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHE41_RS16580	COG1263	PTS System
IHE41_RS16585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IHE41_RS16600	COG4166	transmembrane transport
IHE41_RS16645	COG0259	pyridoxamine-phosphate oxidase activity
IHE41_RS16670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IHE41_RS16715	COG1132	(ABC) transporter
IHE41_RS16725	COG2207	Transcriptional regulator
IHE41_RS16745	COG0513	Belongs to the DEAD box helicase family
IHE41_RS16750	COG2258	MOSC domain
IHE41_RS16765	COG1486	melibiose metabolic process
IHE41_RS16770	COG0583	DNA-binding transcription factor activity
IHE41_RS16785	COG1595	DNA-templated transcription, initiation
IHE41_RS16810	COG3634	alkyl hydroperoxide reductase activity
IHE41_RS16820	COG1846	Transcriptional regulator
IHE41_RS16825	COG1764	response to oxidative stress
IHE41_RS16845	COG0463	Glycosyl transferase, family 2
IHE41_RS16865	COG0826	peptidase U32
IHE41_RS16890	COG1653	transport
IHE41_RS16895	COG0019	diaminopimelate decarboxylase activity
IHE41_RS16900	COG4264	IucA IucC family
IHE41_RS16925	COG4772	TonB-dependent receptor
IHE41_RS16930	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IHE41_RS16935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHE41_RS16940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHE41_RS16945	COG1120	ATPase activity
IHE41_RS16950	COG0840	transmembrane signaling receptor activity
IHE41_RS16955	COG0612	Peptidase, M16
IHE41_RS16965	COG0739	heme binding
IHE41_RS16975	COG2814	Major facilitator Superfamily
IHE41_RS16990	COG4580	involved in the transport of maltose and maltodextrins
IHE41_RS17010	COG2356	endonuclease I
IHE41_RS17030	COG1982	Orn Lys Arg decarboxylase major
IHE41_RS17035	COG0531	amino acid
IHE41_RS17045	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IHE41_RS17055	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IHE41_RS17060	COG1162	GTPase activity
IHE41_RS17065	COG1263	PTS System
IHE41_RS17065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHE41_RS17075	COG1999	signal sequence binding
IHE41_RS17090	COG2909	trisaccharide binding
IHE41_RS17095	COG0058	SHG alpha-glucan phosphorylase activity
IHE41_RS17100	COG1640	4-alpha-glucanotransferase
IHE41_RS17105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IHE41_RS17110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IHE41_RS17115	COG0366	Alpha amylase catalytic
IHE41_RS17130	COG3366	ferrous iron transmembrane transporter activity
IHE41_RS17135	COG0700	Nucleoside recognition
IHE41_RS17140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IHE41_RS17145	COG3339	Conserved Protein
IHE41_RS17150	COG1301	dicarboxylic acid transport
IHE41_RS17160	COG0583	DNA-binding transcription factor activity
IHE41_RS17175	COG0489	protein tyrosine kinase activity
IHE41_RS17175	COG3206	protein involved in exopolysaccharide biosynthesis
IHE41_RS17195	COG2095	MarC family integral membrane protein
IHE41_RS17200	COG4667	esterase of the alpha-beta hydrolase superfamily
IHE41_RS17205	COG3397	chitin binding
IHE41_RS17210	COG1054	Belongs to the UPF0176 family
IHE41_RS17225	COG1686	Belongs to the peptidase S11 family
IHE41_RS17250	COG0583	DNA-binding transcription factor activity
IHE41_RS17255	COG4628	conserved protein (DUF2132)
IHE41_RS17265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IHE41_RS17275	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IHE41_RS17280	COG0628	permease
IHE41_RS17335	COG0454	-acetyltransferase
IHE41_RS17345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IHE41_RS17350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IHE41_RS17355	COG1882	Formate acetyltransferase
IHE41_RS17385	COG1360	Flagellar Motor Protein
IHE41_RS17390	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IHE41_RS17395	COG1191	sigma factor activity
IHE41_RS17400	COG1580	Controls the rotational direction of flagella during chemotaxis
IHE41_RS17415	COG1516	flagellar protein fliS
IHE41_RS17420	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IHE41_RS17430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS17445	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IHE41_RS17455	COG1987	bacterial-type flagellum assembly
IHE41_RS17535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IHE41_RS17555	COG0346	lactoylglutathione lyase activity
IHE41_RS17580	COG0745	RESPONSE REGULATOR receiver
IHE41_RS17600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHE41_RS17610	COG0156	8-amino-7-oxononanoate synthase activity
IHE41_RS17615	COG1063	alcohol dehydrogenase
IHE41_RS17650	COG0668	transmembrane transport
IHE41_RS17660	COG1304	FMN binding
IHE41_RS17665	COG1620	l-lactate permease
IHE41_RS17670	COG0583	DNA-binding transcription factor activity
IHE41_RS17675	COG1505	serine-type exopeptidase activity
IHE41_RS17680	COG4172	Belongs to the ABC transporter superfamily
IHE41_RS17690	COG1067	ATP-dependent peptidase activity
IHE41_RS17715	COG1247	-acetyltransferase
IHE41_RS17720	COG0437	4 iron, 4 sulfur cluster binding
IHE41_RS17725	COG0348	domain, Protein
IHE41_RS17740	COG1122	ATPase activity
IHE41_RS17745	COG4720	Psort location CytoplasmicMembrane, score
IHE41_RS17750	COG1566	PFAM secretion protein HlyD family protein
IHE41_RS17760	COG3706	GGDEF domain
IHE41_RS17775	COG0813	purine-nucleoside phosphorylase activity
IHE41_RS17780	COG3272	Protein of unknown function (DUF1722)
IHE41_RS17785	COG0789	Transcriptional regulator
IHE41_RS17790	COG0415	Belongs to the DNA photolyase family
IHE41_RS17795	COG1376	ErfK ybiS ycfS ynhG family protein
IHE41_RS17795	COG1388	LysM domain
IHE41_RS17805	COG0513	Belongs to the DEAD box helicase family
IHE41_RS17810	COG1770	oligopeptidase
IHE41_RS17815	COG4771	TonB-dependent receptor
IHE41_RS17845	COG0573	inorganic phosphate transmembrane transporter activity
IHE41_RS17850	COG0581	inorganic phosphate transmembrane transporter activity
IHE41_RS17855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IHE41_RS17875	COG2304	oxidoreductase activity
IHE41_RS17895	COG0714	Associated with various cellular activities
IHE41_RS17900	COG0840	transmembrane signaling receptor activity
IHE41_RS17910	COG2197	response regulator
IHE41_RS17960	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IHE41_RS17965	COG1120	ATPase activity
IHE41_RS17970	COG4774	siderophore transport
IHE41_RS17975	COG1132	(ABC) transporter
IHE41_RS17980	COG2205	protein histidine kinase activity
IHE41_RS17980	COG2205	protein histidine kinase activity
IHE41_RS17985	COG0745	RESPONSE REGULATOR receiver
IHE41_RS17990	COG0569	domain protein
IHE41_RS17995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IHE41_RS18005	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IHE41_RS18010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IHE41_RS18025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHE41_RS18025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHE41_RS18025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHE41_RS18030	COG2207	Transcriptional regulator
IHE41_RS18040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHE41_RS18045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHE41_RS18050	COG2084	Dehydrogenase
IHE41_RS18055	COG0753	catalase activity
IHE41_RS18065	COG2130	NADP-dependent
IHE41_RS18070	COG1309	transcriptional regulator
IHE41_RS18075	COG3097	Belongs to the UPF0267 family
IHE41_RS18130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IHE41_RS18135	COG3842	ATPase activity
IHE41_RS18145	COG1175	transmembrane transport
IHE41_RS18150	COG3833	ABC-type maltose transport systems, permease component
IHE41_RS18170	COG3746	phosphate-selective porin O and P
IHE41_RS18185	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS18205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IHE41_RS18215	COG0625	glutathione transferase activity
IHE41_RS18220	COG1686	Belongs to the peptidase S11 family
IHE41_RS18235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IHE41_RS18250	COG1278	Cold shock
IHE41_RS18255	COG1741	Belongs to the pirin family
IHE41_RS18260	COG4667	esterase of the alpha-beta hydrolase superfamily
IHE41_RS18305	COG2194	sulfuric ester hydrolase activity
IHE41_RS18310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IHE41_RS18320	COG2205	protein histidine kinase activity
IHE41_RS18325	COG0745	RESPONSE REGULATOR receiver
IHE41_RS18330	COG4221	oxidoreductase activity
IHE41_RS18345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IHE41_RS18365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IHE41_RS18375	COG2814	Major facilitator Superfamily
IHE41_RS18385	COG1418	mRNA catabolic process
IHE41_RS18395	COG0402	S-adenosylhomocysteine deaminase activity
IHE41_RS18400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IHE41_RS18405	COG2239	Acts as a magnesium transporter
IHE41_RS18410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IHE41_RS18425	COG0531	amino acid
IHE41_RS18430	COG1522	sequence-specific DNA binding
IHE41_RS18455	COG5002	protein histidine kinase activity
IHE41_RS18455	COG0784	Response regulator, receiver
IHE41_RS18455	COG2205	protein histidine kinase activity
IHE41_RS18460	COG0673	inositol 2-dehydrogenase activity
IHE41_RS18465	COG0534	Mate efflux family protein
IHE41_RS18470	COG2926	Belongs to the UPF0265 family
IHE41_RS18480	COG3132	Protein of unknown function, DUF480
IHE41_RS18485	COG2827	Endonuclease containing a URI domain
IHE41_RS18490	COG1879	ABC-type sugar transport system periplasmic component
IHE41_RS18495	COG0784	Response regulator, receiver
IHE41_RS18495	COG2205	protein histidine kinase activity
IHE41_RS18505	COG1566	PFAM secretion protein HlyD family protein
IHE41_RS18525	COG1522	sequence-specific DNA binding
IHE41_RS18550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IHE41_RS18555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IHE41_RS18565	COG1280	lysine exporter protein (LysE YggA)
IHE41_RS18575	COG0183	Belongs to the thiolase family
IHE41_RS18585	COG3243	poly(R)-hydroxyalkanoic acid synthase
IHE41_RS18595	COG3005	denitrification pathway
IHE41_RS18605	COG0243	molybdopterin cofactor binding
IHE41_RS18615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IHE41_RS18620	COG3850	Histidine kinase
IHE41_RS18625	COG2197	response regulator
IHE41_RS18640	COG2195	Cleaves the N-terminal amino acid of tripeptides
IHE41_RS18660	COG0840	transmembrane signaling receptor activity
IHE41_RS18670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IHE41_RS18680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IHE41_RS18685	COG2814	Major facilitator Superfamily
IHE41_RS18690	COG0840	transmembrane signaling receptor activity
IHE41_RS18695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IHE41_RS18700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IHE41_RS18720	COG2897	thiosulfate sulfurtransferase activity
IHE41_RS18740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IHE41_RS18750	COG0302	gtp cyclohydrolase
IHE41_RS18755	COG1914	H( )-stimulated, divalent metal cation uptake system
IHE41_RS18765	COG0038	chloride channel
IHE41_RS18780	COG4989	oxidoreductase activity
IHE41_RS18795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IHE41_RS18795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IHE41_RS18800	COG0516	GMP reductase activity
IHE41_RS18845	COG2433	Pfam Transposase IS66
IHE41_RS18860	COG1061	Type III restriction enzyme res subunit
IHE41_RS18940	COG2977	Belongs to the P-Pant transferase superfamily
IHE41_RS18945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IHE41_RS18950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IHE41_RS19000	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IHE41_RS19015	COG3474	cytochrome
IHE41_RS19025	COG0789	Transcriptional regulator
IHE41_RS19030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IHE41_RS19035	COG0384	phenazine biosynthesis protein PhzF
IHE41_RS19045	COG1294	oxidase, subunit
IHE41_RS19050	COG1271	oxidase subunit
IHE41_RS19055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHE41_RS19060	COG0110	maltose O-acetyltransferase activity
IHE41_RS19065	COG3264	Mechanosensitive ion channel
IHE41_RS19065	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IHE41_RS19080	COG4999	Histidine kinase
IHE41_RS19080	COG3850	Histidine kinase
IHE41_RS19080	COG2205	protein histidine kinase activity
IHE41_RS19080	COG3437	response regulator, receiver
IHE41_RS19095	COG1024	Enoyl-CoA hydratase
IHE41_RS19100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IHE41_RS19105	COG1960	acyl-CoA dehydrogenase activity
IHE41_RS19115	COG0183	Belongs to the thiolase family
IHE41_RS19125	COG1960	acyl-CoA dehydrogenase activity
IHE41_RS19130	COG1024	Enoyl-CoA hydratase
IHE41_RS19145	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS19150	COG3706	GGDEF domain
IHE41_RS19155	COG1309	transcriptional regulator
IHE41_RS19160	COG1012	belongs to the aldehyde dehydrogenase family
IHE41_RS19175	COG4176	ABC-type proline glycine betaine transport system permease component
IHE41_RS19180	COG4175	Glycine betaine
IHE41_RS19180	COG0517	IMP dehydrogenase activity
IHE41_RS19195	COG0330	HflC and HflK could
IHE41_RS19205	COG3300	MHYT domain
IHE41_RS19205	COG5001	Diguanylate cyclase
IHE41_RS19220	COG2205	protein histidine kinase activity
IHE41_RS19220	COG0784	Response regulator, receiver
IHE41_RS19245	COG0582	viral genome integration into host DNA
IHE41_RS19335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IHE41_RS19340	COG5001	Diguanylate cyclase
IHE41_RS19345	COG1869	D-ribose catabolic process
IHE41_RS19350	COG1129	ABC transporter
IHE41_RS19355	COG1172	Belongs to the binding-protein-dependent transport system permease family
IHE41_RS19360	COG1879	ABC-type sugar transport system periplasmic component
IHE41_RS19365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHE41_RS19370	COG1609	Transcriptional regulator
IHE41_RS19385	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IHE41_RS19400	COG0745	RESPONSE REGULATOR receiver
IHE41_RS19415	COG1785	Belongs to the alkaline phosphatase family
IHE41_RS19440	COG0814	amino acid
IHE41_RS19450	COG0243	molybdopterin cofactor binding
IHE41_RS19455	COG1648	precorrin-2 dehydrogenase activity
IHE41_RS19455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IHE41_RS19470	COG3707	response regulator
IHE41_RS19475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IHE41_RS19480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IHE41_RS19485	COG1116	anion transmembrane transporter activity
IHE41_RS19490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IHE41_RS19490	COG2146	nitrite reductase [NAD(P)H] activity
IHE41_RS19545	COG0515	serine threonine protein kinase
IHE41_RS19545	COG2815	serine threonine protein kinase
IHE41_RS19580	COG0631	protein serine/threonine phosphatase activity
IHE41_RS19650	COG0420	3'-5' exonuclease activity
IHE41_RS19655	COG0419	ATPase involved in DNA repair
IHE41_RS19675	COG3040	lipid binding
IHE41_RS19685	COG2814	Major facilitator Superfamily
IHE41_RS19695	COG1288	antiporter activity
IHE41_RS19705	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IHE41_RS19720	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IHE41_RS19735	COG0583	DNA-binding transcription factor activity
IHE41_RS19740	COG0277	FAD linked oxidase domain protein
IHE41_RS19755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IHE41_RS19795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IHE41_RS19795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IHE41_RS19830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IHE41_RS19835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IHE41_RS19845	COG2116	formate transmembrane transporter activity
IHE41_RS19865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IHE41_RS19895	COG0534	Mate efflux family protein
IHE41_RS19900	COG0745	RESPONSE REGULATOR receiver
IHE41_RS19900	COG2205	protein histidine kinase activity
IHE41_RS19900	COG3292	Two component regulator propeller
IHE41_RS19910	COG3118	belongs to the thioredoxin family
IHE41_RS19915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IHE41_RS19940	COG2271	Major facilitator Superfamily
IHE41_RS19945	COG3851	Histidine kinase
IHE41_RS19950	COG2197	response regulator
IHE41_RS19960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IHE41_RS19965	COG0583	DNA-binding transcription factor activity
IHE41_RS19970	COG0243	molybdopterin cofactor binding
IHE41_RS19975	COG0446	pyridine nucleotide-disulphide oxidoreductase
IHE41_RS20000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IHE41_RS20015	COG1328	CTP reductase activity
IHE41_RS20020	COG0602	queuosine metabolic process
IHE41_RS20025	COG0534	Mate efflux family protein
IHE41_RS20040	COG0189	ligase activity
IHE41_RS20040	COG4067	protein conserved in archaea
IHE41_RS20050	COG3111	PFAM Bacterial OB fold (BOF) protein
IHE41_RS20055	COG1492	cobalamin metabolic process
IHE41_RS20060	COG0725	ABC transporter, periplasmic molybdate-binding protein
IHE41_RS20065	COG4149	molybdate abc transporter
IHE41_RS20070	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IHE41_RS20080	COG3706	GGDEF domain
IHE41_RS20080	COG4251	negative regulation of phosphorylation
IHE41_RS20080	COG5001	Diguanylate cyclase
IHE41_RS20080	COG2203	Gaf domain
IHE41_RS20105	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IHE41_RS20110	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IHE41_RS20135	COG3140	Belongs to the UPF0181 family
IHE41_RS20140	COG0589	response to stress
IHE41_RS20150	COG0583	DNA-binding transcription factor activity
IHE41_RS20275	COG4128	Pfam Zonular occludens toxin
IHE41_RS20325	COG4128	Pfam Zonular occludens toxin
IHE41_RS20335	COG0023	Translation Initiation Factor
IHE41_RS20345	COG1181	Belongs to the D-alanine--D-alanine ligase family
IHE41_RS20355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHE41_RS20355	COG0045	succinate-CoA ligase (ADP-forming) activity
IHE41_RS20355	COG1042	CoA-binding domain protein
IHE41_RS20360	COG0583	DNA-binding transcription factor activity
IHE41_RS20365	COG1629	transport
IHE41_RS20365	COG4771	TonB-dependent receptor
IHE41_RS20375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IHE41_RS20380	COG3447	MASE1 domain protein
IHE41_RS20380	COG5001	Diguanylate cyclase
IHE41_RS20380	COG5002	protein histidine kinase activity
IHE41_RS20385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IHE41_RS20390	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IHE41_RS20395	COG1984	allophanate hydrolase subunit 2
IHE41_RS20405	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IHE41_RS20410	COG4181	ATPase activity
IHE41_RS20420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IHE41_RS20425	COG5001	Diguanylate cyclase
IHE41_RS20425	COG3300	MHYT domain
IHE41_RS20435	COG0484	heat shock protein binding
IHE41_RS20460	COG4533	DNA binding
IHE41_RS20470	COG2050	protein possibly involved in aromatic compounds catabolism
IHE41_RS20485	COG2067	long-chain fatty acid transport protein
IHE41_RS20490	COG2267	carboxylic ester hydrolase activity
IHE41_RS20505	COG0861	Integral membrane protein TerC family
IHE41_RS20510	COG0737	Belongs to the 5'-nucleotidase family
IHE41_RS20515	COG3593	DNA synthesis involved in DNA repair
IHE41_RS20525	COG0583	DNA-binding transcription factor activity
IHE41_RS20530	COG2116	formate transmembrane transporter activity
IHE41_RS20535	COG2353	YceI-like domain
IHE41_RS20540	COG3038	cytochrome b561
IHE41_RS20555	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IHE41_RS20560	COG0513	Belongs to the DEAD box helicase family
IHE41_RS20565	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IHE41_RS20570	COG0840	transmembrane signaling receptor activity
IHE41_RS20575	COG0546	phosphoglycolate phosphatase activity
IHE41_RS20580	COG0784	Response regulator, receiver
IHE41_RS20580	COG3437	response regulator, receiver
IHE41_RS20595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHE41_RS20600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IHE41_RS20605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IHE41_RS20615	COG2207	Transcriptional regulator
IHE41_RS20620	COG1979	alcohol dehydrogenase
IHE41_RS20645	COG2271	Major facilitator Superfamily
IHE41_RS20650	COG0469	pyruvate kinase activity
IHE41_RS20655	COG1126	abc transporter atp-binding protein
IHE41_RS20660	COG0765	amino acid transport
IHE41_RS20665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHE41_RS20670	COG0765	amino acid transport
IHE41_RS20675	COG2203	Gaf domain
IHE41_RS20675	COG2200	EAL domain
IHE41_RS20675	COG2199	diguanylate cyclase activity
IHE41_RS20690	COG1609	Transcriptional regulator
IHE41_RS20695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHE41_RS20695	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHE41_RS20700	COG1105	Belongs to the carbohydrate kinase PfkB family
IHE41_RS20705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHE41_RS20705	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IHE41_RS20705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHE41_RS20745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IHE41_RS20750	COG0509	glycine decarboxylation via glycine cleavage system
IHE41_RS20755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IHE41_RS20755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IHE41_RS20785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IHE41_RS20790	COG0583	DNA-binding transcription factor activity
IHE41_RS20795	COG2176	DNA-directed DNA polymerase activity
IHE41_RS20835	COG0242	peptide deformylase activity
IHE41_RS20865	COG2239	Acts as a magnesium transporter
IHE41_RS20885	COG0346	lactoylglutathione lyase activity
IHE41_RS20890	COG1902	pentaerythritol trinitrate reductase activity
IHE41_RS20910	COG5642	Protein of unknown function (DUF2384)
IHE41_RS20915	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IHE41_RS20930	COG4565	transcriptional regulatory protein
IHE41_RS20935	COG3290	protein histidine kinase activity
IHE41_RS20940	COG0471	metal ion transport
IHE41_RS20970	COG2076	Multidrug Resistance protein
IHE41_RS20985	COG0671	phosphoesterase, PA-phosphatase related
IHE41_RS20995	COG2962	Rard protein
IHE41_RS21010	COG0835	chemotaxis
IHE41_RS21010	COG0784	Response regulator, receiver
IHE41_RS21025	COG2197	response regulator
IHE41_RS21035	COG3706	GGDEF domain
IHE41_RS21040	COG2197	response regulator
IHE41_RS21045	COG5001	Diguanylate cyclase
IHE41_RS21045	COG3300	MHYT domain
IHE41_RS21060	COG0583	DNA-binding transcription factor activity
IHE41_RS21065	COG0583	DNA-binding transcription factor activity
IHE41_RS21125	COG4964	Belongs to the GSP D family
IHE41_RS21150	COG2207	Transcriptional regulator
IHE41_RS21170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IHE41_RS21190	COG0456	acetyltransferase
IHE41_RS21190	COG1214	PFAM Peptidase M22, glycoprotease
IHE41_RS21200	COG3069	C4-dicarboxylate transmembrane transporter activity
IHE41_RS21205	COG1704	LemA family
IHE41_RS21210	COG0501	Belongs to the peptidase M48B family
IHE41_RS21235	COG0641	radical SAM
IHE41_RS21250	COG3111	PFAM Bacterial OB fold (BOF) protein
IHE41_RS21255	COG1597	lipid kinase activity
IHE41_RS21260	COG0583	DNA-binding transcription factor activity
IHE41_RS21265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IHE41_RS21295	COG0714	Associated with various cellular activities
IHE41_RS21300	COG0641	radical SAM
IHE41_RS21305	COG3119	arylsulfatase activity
IHE41_RS21320	COG3119	arylsulfatase activity
IHE41_RS21325	COG3119	arylsulfatase activity
IHE41_RS21330	COG0745	RESPONSE REGULATOR receiver
IHE41_RS21345	COG2205	protein histidine kinase activity
IHE41_RS21345	COG2198	Histidine kinase
IHE41_RS21345	COG0784	Response regulator, receiver
IHE41_RS21350	COG1879	ABC-type sugar transport system periplasmic component
IHE41_RS21355	COG1803	Methylglyoxal synthase
IHE41_RS21360	COG0210	DNA helicase
IHE41_RS21365	COG1289	transmembrane transporter activity
IHE41_RS21395	COG1629	transport
IHE41_RS21395	COG4771	TonB-dependent receptor
IHE41_RS21405	COG0789	Transcriptional regulator
IHE41_RS21410	COG4604	ABC transporter, ATP-binding protein
IHE41_RS21415	COG4605	iron ion homeostasis
IHE41_RS21420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHE41_RS21425	COG4607	ABC-type enterochelin transport system periplasmic component
IHE41_RS21445	COG2847	Copper chaperone PCu(A)C
IHE41_RS21450	COG0443	Heat shock 70 kDa protein
IHE41_RS21485	COG0625	glutathione transferase activity
IHE41_RS21500	COG4160	amino acid transport
IHE41_RS21505	COG4215	(ABC) transporter
IHE41_RS21510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHE41_RS21515	COG1126	abc transporter atp-binding protein
IHE41_RS21525	COG1902	pentaerythritol trinitrate reductase activity
IHE41_RS21535	COG0109	protoheme IX farnesyltransferase activity
IHE41_RS21540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IHE41_RS21545	COG1845	cytochrome c oxidase, subunit III
IHE41_RS21550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IHE41_RS21555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IHE41_RS21560	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS21570	COG1024	Enoyl-CoA hydratase
IHE41_RS21575	COG1024	Enoyl-CoA hydratase
IHE41_RS21590	COG0183	Belongs to the thiolase family
IHE41_RS21600	COG1960	acyl-CoA dehydrogenase activity
IHE41_RS21605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IHE41_RS21610	COG1024	Enoyl-CoA hydratase
IHE41_RS21620	COG5413	integral membrane protein
IHE41_RS21640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IHE41_RS21645	COG5001	Diguanylate cyclase
IHE41_RS21650	COG0513	Belongs to the DEAD box helicase family
IHE41_RS21655	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IHE41_RS21670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IHE41_RS21690	COG0641	radical SAM
IHE41_RS21710	COG0840	transmembrane signaling receptor activity
IHE41_RS21715	COG1119	ATPase activity
IHE41_RS21720	COG2200	EAL domain
IHE41_RS21740	COG0513	Belongs to the DEAD box helicase family
IHE41_RS21745	COG0523	cobalamin synthesis protein
IHE41_RS21755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IHE41_RS21765	COG0133	tryptophan synthase activity
IHE41_RS21770	COG4628	conserved protein (DUF2132)
IHE41_RS21775	COG0513	Belongs to the DEAD box helicase family
IHE41_RS21780	COG3530	Putative quorum-sensing-regulated virulence factor
IHE41_RS21800	COG2154	pterin-4-alpha-carbinolamine dehydratase
IHE41_RS21805	COG3186	Phenylalanine-4-hydroxylase
IHE41_RS21810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IHE41_RS21815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IHE41_RS21855	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IHE41_RS21860	COG1454	alcohol dehydrogenase
IHE41_RS21865	COG2133	pyrroloquinoline quinone binding
IHE41_RS21875	COG0783	Belongs to the Dps family
IHE41_RS21880	COG0840	transmembrane signaling receptor activity
IHE41_RS21890	COG0577	efflux transmembrane transporter activity
IHE41_RS21890	COG1136	(ABC) transporter
IHE41_RS21910	COG2199	diguanylate cyclase activity
IHE41_RS21925	COG3036	rescue of stalled ribosome
IHE41_RS21930	COG1278	Cold shock
IHE41_RS21960	COG0545	Peptidyl-prolyl cis-trans isomerase
IHE41_RS21965	COG0109	protoheme IX farnesyltransferase activity
IHE41_RS21970	COG1612	heme a metabolic process
IHE41_RS21995	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IHE41_RS22010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IHE41_RS22020	COG1280	lysine exporter protein (LysE YggA)
IHE41_RS22025	COG2207	Transcriptional regulator
IHE41_RS22050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IHE41_RS22055	COG0697	spore germination
IHE41_RS22075	COG2814	Major facilitator Superfamily
IHE41_RS22080	COG0583	DNA-binding transcription factor activity
IHE41_RS22085	COG5001	Diguanylate cyclase
IHE41_RS22090	COG0739	heme binding
IHE41_RS22110	COG3314	Sporulation integral membrane protein YlbJ
IHE41_RS22125	COG0814	amino acid
IHE41_RS22145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IHE41_RS22150	COG1072	(Pantothenic acid kinase))
IHE41_RS22160	COG1063	alcohol dehydrogenase
IHE41_RS22165	COG2213	PTS system mannitol-specific
IHE41_RS22170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHE41_RS22185	COG0798	PFAM Bile acid sodium symporter
IHE41_RS22195	COG1881	PFAM PEBP family protein
IHE41_RS22205	COG2706	6-phosphogluconolactonase activity
IHE41_RS22220	COG1131	(ABC) transporter
IHE41_RS22225	COG0842	Transport permease protein
IHE41_RS22240	COG3383	formate dehydrogenase (NAD+) activity
IHE41_RS22260	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IHE41_RS22290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHE41_RS22300	COG2067	long-chain fatty acid transport protein
IHE41_RS22310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS22320	COG1505	serine-type exopeptidase activity
IHE41_RS22325	COG0488	(ABC) transporter
IHE41_RS22330	COG0589	response to stress
IHE41_RS22335	COG2249	NAD(P)H dehydrogenase (quinone) activity
IHE41_RS22355	COG0366	Alpha amylase catalytic
IHE41_RS22365	COG4934	collagen metabolic process
IHE41_RS22380	COG0583	DNA-binding transcription factor activity
IHE41_RS22385	COG0783	Belongs to the Dps family
IHE41_RS22390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IHE41_RS22420	COG0210	DNA helicase
IHE41_RS22425	COG2814	Major facilitator Superfamily
IHE41_RS22460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IHE41_RS22465	COG0784	Response regulator, receiver
IHE41_RS22465	COG0835	chemotaxis
IHE41_RS22475	COG0748	coenzyme F420 binding
IHE41_RS22480	COG3721	Heme iron utilization protein
IHE41_RS22490	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IHE41_RS22495	COG0811	peptide transport
IHE41_RS22500	COG0848	biopolymer transport protein
IHE41_RS22510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHE41_RS22515	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IHE41_RS22555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IHE41_RS22560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IHE41_RS22565	COG0633	Ferredoxin
IHE41_RS22565	COG3217	Mosc domain protein beta barrel domain protein
IHE41_RS22565	COG0633	Ferredoxin
IHE41_RS22565	COG3217	Mosc domain protein beta barrel domain protein
IHE41_RS22570	COG0401	homolog of Blt101
IHE41_RS22575	COG0418	dihydroorotase activity
IHE41_RS22580	COG2354	Protein conserved in bacteria
IHE41_RS22610	COG2207	Transcriptional regulator
IHE41_RS22610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IHE41_RS22615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHE41_RS22655	COG0513	Belongs to the DEAD box helicase family
IHE41_RS22665	COG0583	DNA-binding transcription factor activity
IHE41_RS22680	COG1902	pentaerythritol trinitrate reductase activity
IHE41_RS22685	COG1063	alcohol dehydrogenase
IHE41_RS22695	COG1028	Short-chain dehydrogenase reductase Sdr
IHE41_RS22705	COG3122	Protein conserved in bacteria
IHE41_RS22720	COG0583	DNA-binding transcription factor activity
IHE41_RS22725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IHE41_RS22730	COG0252	asparaginase activity
IHE41_RS22735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IHE41_RS22740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IHE41_RS22740	COG0574	Belongs to the PEP-utilizing enzyme family
IHE41_RS22755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IHE41_RS22775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS22795	COG3706	GGDEF domain
IHE41_RS22815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IHE41_RS22845	COG3842	ATPase activity
IHE41_RS22880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IHE41_RS22915	COG0583	DNA-binding transcription factor activity
IHE41_RS22925	COG4948	Mandelate Racemase Muconate Lactonizing
IHE41_RS22955	COG1342	Belongs to the UPF0251 family
IHE41_RS22960	COG3015	lipoprotein NlpE involved in copper resistance
IHE41_RS22965	COG3713	MltA-interacting MipA family protein
IHE41_RS22980	COG0583	DNA-binding transcription factor activity
IHE41_RS23000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IHE41_RS23010	COG1335	isochorismatase
IHE41_RS23020	COG0753	catalase activity
IHE41_RS23030	COG1349	DNA-binding transcription factor activity
IHE41_RS23035	COG0346	lactoylglutathione lyase activity
IHE41_RS23050	COG0583	DNA-binding transcription factor activity
IHE41_RS23060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHE41_RS23070	COG0737	Belongs to the 5'-nucleotidase family
IHE41_RS23080	COG1309	transcriptional regulator
IHE41_RS23100	COG1280	lysine exporter protein (LysE YggA)
IHE41_RS23115	COG0459	protein refolding
IHE41_RS23120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IHE41_RS23125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IHE41_RS23150	COG1304	FMN binding
IHE41_RS23170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHE41_RS23175	COG1256	bacterial-type flagellum assembly
IHE41_RS23175	COG4786	Flagellar basal body rod
IHE41_RS23185	COG1706	bacterial-type flagellum-dependent cell motility
IHE41_RS23190	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IHE41_RS23195	COG4786	Flagellar basal body rod
IHE41_RS23200	COG4787	bacterial-type flagellum-dependent cell motility
IHE41_RS23205	COG1749	Flagellar hook protein flgE
IHE41_RS23210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IHE41_RS23215	COG1558	bacterial-type flagellum-dependent cell motility
IHE41_RS23220	COG1815	bacterial-type flagellum-dependent cell motility
IHE41_RS23240	COG0741	lytic transglycosylase activity
IHE41_RS23245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IHE41_RS23265	COG1760	l-serine dehydratase
IHE41_RS23270	COG3104	oligopeptide transport
IHE41_RS23290	COG0583	DNA-binding transcription factor activity
IHE41_RS23300	COG2866	Carboxypeptidase
IHE41_RS23305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IHE41_RS23310	COG2990	Protein conserved in bacteria
IHE41_RS23335	COG3842	ATPase activity
IHE41_RS23345	COG1840	ABC-type Fe3 transport system, periplasmic component
IHE41_RS23355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IHE41_RS23360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IHE41_RS23365	COG1609	Transcriptional regulator
IHE41_RS23395	COG3240	lipase activity
IHE41_RS23405	COG1136	(ABC) transporter
IHE41_RS23405	COG0577	efflux transmembrane transporter activity
IHE41_RS23410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHE41_RS23415	COG2067	long-chain fatty acid transport protein
IHE41_RS23425	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IHE41_RS23440	COG1011	Hydrolase
IHE41_RS23480	COG0110	maltose O-acetyltransferase activity
IHE41_RS23485	COG1765	OsmC-like protein
IHE41_RS23490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IHE41_RS23490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IHE41_RS23505	COG3046	protein related to deoxyribodipyrimidine photolyase
IHE41_RS23510	COG0415	Belongs to the DNA photolyase family
IHE41_RS23515	COG3706	GGDEF domain
IHE41_RS23530	COG0840	transmembrane signaling receptor activity
IHE41_RS23535	COG3706	GGDEF domain
IHE41_RS23550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IHE41_RS23565	COG3033	Beta-eliminating lyase
IHE41_RS23575	COG0579	oxidoreductase
IHE41_RS23595	COG2199	diguanylate cyclase activity
IHE41_RS23635	COG0583	DNA-binding transcription factor activity
IHE41_RS23640	COG0189	ligase activity
IHE41_RS23645	COG0189	ligase activity
IHE41_RS23645	COG4067	protein conserved in archaea
IHE41_RS23655	COG1166	arginine decarboxylase activity
IHE41_RS23660	COG0010	Belongs to the arginase family
IHE41_RS23665	COG2814	Major facilitator Superfamily
IHE41_RS23670	COG1770	oligopeptidase
IHE41_RS23685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IHE41_RS23690	COG1121	(ABC) transporter
IHE41_RS23695	COG0803	Belongs to the bacterial solute-binding protein 9 family
IHE41_RS23735	COG0848	biopolymer transport protein
IHE41_RS23740	COG0811	peptide transport
IHE41_RS23745	COG0811	peptide transport
IHE41_RS23765	COG0745	RESPONSE REGULATOR receiver
IHE41_RS23770	COG0039	L-malate dehydrogenase activity
IHE41_RS23775	COG0584	glycerophosphoryl diester phosphodiesterase
IHE41_RS23785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family