locus-tag	class	description
I5M77_RS00005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I5M77_RS00010	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M77_RS00015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M77_RS00030	COG0288	reversible hydration of carbon dioxide
I5M77_RS00035	COG0659	secondary active sulfate transmembrane transporter activity
I5M77_RS00040	COG1131	(ABC) transporter
I5M77_RS00045	COG0842	Transport permease protein
I5M77_RS00050	COG1560	Kdo2-lipid A biosynthetic process
I5M77_RS00055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5M77_RS00060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I5M77_RS00065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5M77_RS00075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5M77_RS00085	COG1489	DNA binding
I5M77_RS00090	COG1643	Atp-dependent helicase
I5M77_RS00095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M77_RS00100	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5M77_RS00105	COG1049	propionate catabolic process, 2-methylcitrate cycle
I5M77_RS00110	COG3112	Uncharacterised protein family (UPF0231)
I5M77_RS00120	COG0004	ammonium transporteR
I5M77_RS00125	COG1840	ABC-type Fe3 transport system, periplasmic component
I5M77_RS00135	COG3842	ATPase activity
I5M77_RS00140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5M77_RS00155	COG2971	BadF BadG BcrA BcrD
I5M77_RS00165	COG4608	Belongs to the ABC transporter superfamily
I5M77_RS00170	COG0444	Belongs to the ABC transporter superfamily
I5M77_RS00175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M77_RS00185	COG0747	negative chemotaxis
I5M77_RS00190	COG0784	Response regulator, receiver
I5M77_RS00190	COG2198	Histidine kinase
I5M77_RS00190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M77_RS00190	COG2205	protein histidine kinase activity
I5M77_RS00195	COG2813	Specifically methylates the guanine in position
I5M77_RS00200	COG0628	permease
I5M77_RS00205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5M77_RS00210	COG0316	Belongs to the HesB IscA family
I5M77_RS00225	COG0739	heme binding
I5M77_RS00230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5M77_RS00240	COG2027	D-alanyl-D-alanine carboxypeptidase
I5M77_RS00245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M77_RS00250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M77_RS00255	COG1534	Rna-binding protein
I5M77_RS00260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I5M77_RS00265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5M77_RS00270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5M77_RS00275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5M77_RS00280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5M77_RS00295	COG0779	Required for maturation of 30S ribosomal subunits
I5M77_RS00300	COG0195	Participates in both transcription termination and antitermination
I5M77_RS00305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I5M77_RS00310	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5M77_RS00315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5M77_RS00320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I5M77_RS00325	COG1185	polyribonucleotide nucleotidyltransferase activity
I5M77_RS00340	COG0534	Mate efflux family protein
I5M77_RS00345	COG0826	peptidase U32
I5M77_RS00350	COG0826	peptidase U32
I5M77_RS00360	COG3154	lipid carrier protein
I5M77_RS00365	COG3153	acetyltransferase
I5M77_RS00385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I5M77_RS00395	COG0084	hydrolase, TatD family'
I5M77_RS00400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M77_RS00405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I5M77_RS00410	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I5M77_RS00415	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I5M77_RS00420	COG0813	purine-nucleoside phosphorylase activity
I5M77_RS00430	COG0560	Phosphoserine phosphatase
I5M77_RS00440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5M77_RS00445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5M77_RS00450	COG0583	DNA-binding transcription factor activity
I5M77_RS00460	COG1022	Amp-dependent synthetase and ligase
I5M77_RS00465	COG2169	Transcriptional regulator
I5M77_RS00490	COG4964	Belongs to the GSP D family
I5M77_RS00550	COG0583	DNA-binding transcription factor activity
I5M77_RS00555	COG0531	amino acid
I5M77_RS00560	COG2731	YhcH YjgK YiaL family protein
I5M77_RS00565	COG3250	beta-galactosidase activity
I5M77_RS00570	COG1609	Transcriptional regulator
I5M77_RS00575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5M77_RS00585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I5M77_RS00590	COG2017	converts alpha-aldose to the beta-anomer
I5M77_RS00605	COG2211	Major facilitator Superfamily
I5M77_RS00610	COG1609	Transcriptional regulator
I5M77_RS00615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M77_RS00630	COG0598	Magnesium transport protein CorA
I5M77_RS00635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M77_RS00640	COG1349	DNA-binding transcription factor activity
I5M77_RS00645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5M77_RS00650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5M77_RS00655	COG2271	Major facilitator Superfamily
I5M77_RS00660	COG0584	glycerophosphoryl diester phosphodiesterase
I5M77_RS00665	COG2171	N-acyltransferase activity
I5M77_RS00670	COG3141	response to X-ray
I5M77_RS00690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5M77_RS00695	COG1074	ATP-dependent DNA helicase activity
I5M77_RS00700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5M77_RS00710	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5M77_RS00710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5M77_RS00720	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I5M77_RS00725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5M77_RS00730	COG2166	iron-sulfur cluster assembly
I5M77_RS00735	COG3706	GGDEF domain
I5M77_RS00740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5M77_RS00745	COG0693	protein deglycase activity
I5M77_RS00750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5M77_RS00775	COG1595	DNA-templated transcription, initiation
I5M77_RS00795	COG3056	Lipoprotein
I5M77_RS00800	COG2813	Specifically methylates the guanine in position
I5M77_RS00805	COG0271	Belongs to the BolA IbaG family
I5M77_RS00810	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M77_RS00815	COG1805	sodium ion transport
I5M77_RS00820	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M77_RS00825	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M77_RS00830	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M77_RS00835	COG2871	sodium ion transport
I5M77_RS00840	COG1477	protein flavinylation
I5M77_RS00855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5M77_RS00860	COG0514	ATP-dependent DNA helicase (RecQ)
I5M77_RS00865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M77_RS00880	COG0733	neurotransmitter:sodium symporter activity
I5M77_RS00900	COG0442	prolyl-tRNA aminoacylation
I5M77_RS00905	COG1720	tRNA m6t6A37 methyltransferase activity
I5M77_RS00910	COG0254	rRNA binding
I5M77_RS00920	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5M77_RS00925	COG1671	Belongs to the UPF0178 family
I5M77_RS00950	COG3098	single-species biofilm formation
I5M77_RS00955	COG0564	pseudouridine synthase activity
I5M77_RS00965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I5M77_RS00970	COG0024	Methionine aminopeptidase
I5M77_RS00975	COG0052	Belongs to the universal ribosomal protein uS2 family
I5M77_RS00980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I5M77_RS00985	COG0528	UMP kinase activity
I5M77_RS00990	COG0233	cytoplasmic translational termination
I5M77_RS00995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I5M77_RS01000	COG0575	Belongs to the CDS family
I5M77_RS01005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5M77_RS01010	COG0750	zinc metalloprotease
I5M77_RS01020	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I5M77_RS01025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5M77_RS01030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5M77_RS01035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5M77_RS01040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5M77_RS01045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I5M77_RS01050	COG0587	DNA-directed DNA polymerase activity
I5M77_RS01055	COG0825	malonyl-CoA metabolic process
I5M77_RS01060	COG0037	tRNA processing
I5M77_RS01070	COG0347	Belongs to the P(II) protein family
I5M77_RS01075	COG3021	interspecies interaction between organisms
I5M77_RS01085	COG0741	lytic transglycosylase activity
I5M77_RS01085	COG1388	LysM domain
I5M77_RS01090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M77_RS01095	COG2226	methyltransferase
I5M77_RS01100	COG0328	RNA-DNA hybrid ribonuclease activity
I5M77_RS01105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M77_RS01120	COG1960	acyl-CoA dehydrogenase activity
I5M77_RS01125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I5M77_RS01130	COG0121	glutamine amidotransferase
I5M77_RS01135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5M77_RS01140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I5M77_RS01145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5M77_RS01150	COG2233	PERMEase
I5M77_RS01170	COG1393	Belongs to the ArsC family
I5M77_RS01175	COG4783	chaperone-mediated protein folding
I5M77_RS01190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5M77_RS01240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5M77_RS01270	COG2716	regulation of RNA biosynthetic process
I5M77_RS01275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5M77_RS01280	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5M77_RS01295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5M77_RS01300	COG1393	Belongs to the ArsC family
I5M77_RS01325	COG2837	iron assimilation
I5M77_RS01330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS01335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS01340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS01345	COG1334	flagellar protein FlaG
I5M77_RS01350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5M77_RS01360	COG1516	flagellar protein fliS
I5M77_RS01380	COG1677	Flagellar hook-basal body complex protein FliE
I5M77_RS01390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5M77_RS01440	COG1987	bacterial-type flagellum assembly
I5M77_RS01480	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I5M77_RS01485	COG0643	Histidine kinase
I5M77_RS01485	COG0784	Response regulator, receiver
I5M77_RS01485	COG2198	Histidine kinase
I5M77_RS01490	COG2201	protein-glutamate methylesterase activity
I5M77_RS01495	COG1192	Involved in chromosome partitioning
I5M77_RS01505	COG0835	chemotaxis
I5M77_RS01515	COG4133	protoheme IX ABC transporter activity
I5M77_RS01520	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M77_RS01525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M77_RS01530	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M77_RS01535	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I5M77_RS01540	COG1138	Cytochrome C-type biogenesis protein
I5M77_RS01545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5M77_RS01560	COG2853	Lipoprotein
I5M77_RS01565	COG2067	long-chain fatty acid transport protein
I5M77_RS01570	COG2067	long-chain fatty acid transport protein
I5M77_RS01585	COG0183	Belongs to the thiolase family
I5M77_RS01590	COG1024	Enoyl-CoA hydratase
I5M77_RS01590	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M77_RS01605	COG2062	phosphohistidine phosphatase, SixA
I5M77_RS01610	COG2840	Smr protein MutS2
I5M77_RS01615	COG2890	protein-(glutamine-N5) methyltransferase activity
I5M77_RS01620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I5M77_RS01625	COG2860	membrane
I5M77_RS01630	COG3101	peptidyl-lysine hydroxylation
I5M77_RS01640	COG0431	NADPH-dependent FMN reductase
I5M77_RS01645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I5M77_RS01645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M77_RS01650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M77_RS01655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M77_RS01660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M77_RS01670	COG0101	tRNA pseudouridine synthase activity
I5M77_RS01675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I5M77_RS01680	COG0285	dihydrofolate synthase activity
I5M77_RS01685	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I5M77_RS01690	COG1286	toxin biosynthetic process
I5M77_RS01695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5M77_RS01700	COG0583	DNA-binding transcription factor activity
I5M77_RS01705	COG0745	RESPONSE REGULATOR receiver
I5M77_RS01710	COG2832	Protein of unknown function (DUF454)
I5M77_RS01715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5M77_RS01725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I5M77_RS01730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5M77_RS01735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5M77_RS01740	COG0814	amino acid
I5M77_RS01745	COG0251	oxidation-reduction process
I5M77_RS01750	COG3681	Belongs to the UPF0597 family
I5M77_RS01765	COG2261	transglycosylase associated protein
I5M77_RS01770	COG2983	Belongs to the UPF0260 family
I5M77_RS01775	COG0668	transmembrane transport
I5M77_RS01780	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I5M77_RS01785	COG0346	lactoylglutathione lyase activity
I5M77_RS01795	COG1785	Belongs to the alkaline phosphatase family
I5M77_RS01810	COG2226	methyltransferase
I5M77_RS01825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5M77_RS01830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5M77_RS01840	COG3139	Protein of unknown function (DUF1315)
I5M77_RS01845	COG0252	asparaginase activity
I5M77_RS01850	COG0616	signal peptide processing
I5M77_RS01855	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5M77_RS01855	COG1902	pentaerythritol trinitrate reductase activity
I5M77_RS01860	COG0778	Nitroreductase
I5M77_RS01865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M77_RS01880	COG0123	including yeast histone deacetylase and acetoin utilization protein
I5M77_RS01890	COG3083	sulfuric ester hydrolase activity
I5M77_RS01895	COG3082	Protein of unknown function (DUF1414)
I5M77_RS01900	COG3081	Nucleoid-associated protein
I5M77_RS01915	COG1757	Na H antiporter
I5M77_RS01920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M77_RS01925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M77_RS01930	COG2095	MarC family integral membrane protein
I5M77_RS01935	COG1454	alcohol dehydrogenase
I5M77_RS01935	COG1012	belongs to the aldehyde dehydrogenase family
I5M77_RS01955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5M77_RS01965	COG2056	Na+-H+ antiporter family
I5M77_RS01970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M77_RS01975	COG2885	chlorophyll binding
I5M77_RS01985	COG0346	lactoylglutathione lyase activity
I5M77_RS01990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5M77_RS01995	COG4660	Part of a membrane complex involved in electron transport
I5M77_RS02000	COG4659	FMN binding
I5M77_RS02005	COG4658	electron transport chain
I5M77_RS02010	COG4656	Part of a membrane complex involved in electron transport
I5M77_RS02015	COG2878	Part of a membrane complex involved in electron transport
I5M77_RS02020	COG4657	Part of a membrane complex involved in electron transport
I5M77_RS02030	COG0556	nucleotide-excision repair
I5M77_RS02035	COG2204	response regulator
I5M77_RS02040	COG2198	Histidine kinase
I5M77_RS02045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I5M77_RS02050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I5M77_RS02055	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M77_RS02060	COG0315	cyclic pyranopterin monophosphate synthase activity
I5M77_RS02065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5M77_RS02070	COG0314	molybdopterin synthase activity
I5M77_RS02080	COG0601	transmembrane transport
I5M77_RS02085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M77_RS02090	COG0444	Belongs to the ABC transporter superfamily
I5M77_RS02100	COG0435	Glutathione S-transferase
I5M77_RS02110	COG3174	membrane
I5M77_RS02115	COG0857	belongs to the CobB CobQ family
I5M77_RS02115	COG0280	phosphate acetyltransferase
I5M77_RS02120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I5M77_RS02125	COG3092	negative regulation of chromosome organization
I5M77_RS02135	COG4120	Belongs to the binding-protein-dependent transport system permease family
I5M77_RS02140	COG1122	ATPase activity
I5M77_RS02145	COG0366	Alpha amylase catalytic
I5M77_RS02155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M77_RS02160	COG3318	Belongs to the UPF0149 family
I5M77_RS02160	COG3012	SEC-C Motif Domain Protein
I5M77_RS02165	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I5M77_RS02170	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5M77_RS02175	COG2186	Transcriptional regulator
I5M77_RS02185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M77_RS02185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M77_RS02190	COG0489	protein tyrosine kinase activity
I5M77_RS02195	COG0572	uridine kinase
I5M77_RS02205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I5M77_RS02210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5M77_RS02215	COG0659	secondary active sulfate transmembrane transporter activity
I5M77_RS02220	COG1530	ribonuclease E activity
I5M77_RS02225	COG0564	pseudouridine synthase activity
I5M77_RS02230	COG0424	maF-like protein
I5M77_RS02235	COG1399	metal-binding, possibly nucleic acid-binding protein
I5M77_RS02245	COG0416	fatty acid biosynthetic process
I5M77_RS02250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5M77_RS02280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5M77_RS02285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I5M77_RS02295	COG0084	hydrolase, TatD family'
I5M77_RS02300	COG1263	PTS System
I5M77_RS02300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M77_RS02315	COG0733	neurotransmitter:sodium symporter activity
I5M77_RS02330	COG4667	esterase of the alpha-beta hydrolase superfamily
I5M77_RS02335	COG0469	pyruvate kinase activity
I5M77_RS02340	COG1940	carbohydrate kinase activity
I5M77_RS02345	COG0835	chemotaxis
I5M77_RS02345	COG0784	Response regulator, receiver
I5M77_RS02350	COG0587	DNA-directed DNA polymerase activity
I5M77_RS02365	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS02370	COG0616	signal peptide processing
I5M77_RS02375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I5M77_RS02380	COG0539	negative regulation of cytoplasmic translation
I5M77_RS02390	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I5M77_RS02395	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I5M77_RS02400	COG0284	orotidine-5'-phosphate decarboxylase activity
I5M77_RS02405	COG4166	transmembrane transport
I5M77_RS02430	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I5M77_RS02440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M77_RS02440	COG3008	intermembrane lipid transfer
I5M77_RS02445	COG2995	paraquat-inducible protein a
I5M77_RS02450	COG3258	Cytochrome c
I5M77_RS02455	COG2863	cytochrome
I5M77_RS02495	COG4232	protein-disulfide reductase activity
I5M77_RS02500	COG3118	belongs to the thioredoxin family
I5M77_RS02530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS02540	COG0577	efflux transmembrane transporter activity
I5M77_RS02540	COG1136	(ABC) transporter
I5M77_RS02550	COG1136	(ABC) transporter
I5M77_RS02550	COG0577	efflux transmembrane transporter activity
I5M77_RS02555	COG1335	isochorismatase
I5M77_RS02605	COG3850	Histidine kinase
I5M77_RS02605	COG5002	protein histidine kinase activity
I5M77_RS02610	COG0745	RESPONSE REGULATOR receiver
I5M77_RS02615	COG0840	transmembrane signaling receptor activity
I5M77_RS02620	COG1032	radical SAM domain protein
I5M77_RS02625	COG5001	Diguanylate cyclase
I5M77_RS02625	COG3706	GGDEF domain
I5M77_RS02625	COG4251	negative regulation of phosphorylation
I5M77_RS02625	COG2203	Gaf domain
I5M77_RS02640	COG0583	DNA-binding transcription factor activity
I5M77_RS02645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5M77_RS02655	COG2350	Protein conserved in bacteria
I5M77_RS02665	COG2917	probably involved in intracellular septation
I5M77_RS02685	COG1301	dicarboxylic acid transport
I5M77_RS02690	COG0318	PFAM AMP-dependent synthetase and ligase
I5M77_RS02695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M77_RS02700	COG0159	tryptophan synthase activity
I5M77_RS02705	COG0133	tryptophan synthase activity
I5M77_RS02710	COG0134	indole-3-glycerol-phosphate synthase activity
I5M77_RS02710	COG0135	phosphoribosylanthranilate isomerase activity
I5M77_RS02715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M77_RS02720	COG0512	Glutamine amidotransferase of anthranilate synthase
I5M77_RS02725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5M77_RS02735	COG0613	PHP domain protein
I5M77_RS02740	COG0009	L-threonylcarbamoyladenylate synthase
I5M77_RS02750	COG1187	pseudouridine synthase activity
I5M77_RS02755	COG3099	Belongs to the UPF0263 family
I5M77_RS02760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I5M77_RS02770	COG0417	DNA replication proofreading
I5M77_RS02775	COG2197	response regulator
I5M77_RS02780	COG0322	excinuclease ABC activity
I5M77_RS02820	COG0019	diaminopimelate decarboxylase activity
I5M77_RS02845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5M77_RS02850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5M77_RS02855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5M77_RS02875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I5M77_RS02885	COG0437	4 iron, 4 sulfur cluster binding
I5M77_RS02890	COG3301	Polysulphide reductase, NrfD
I5M77_RS02895	COG1138	Cytochrome C-type biogenesis protein
I5M77_RS02905	COG3088	subunit of a heme lyase
I5M77_RS02905	COG4235	cytochrome complex assembly
I5M77_RS02915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5M77_RS02940	COG2989	Protein conserved in bacteria
I5M77_RS02945	COG3108	Peptidase M15
I5M77_RS02950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M77_RS02965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I5M77_RS02990	COG1846	Transcriptional regulator
I5M77_RS02995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M77_RS03000	COG0840	transmembrane signaling receptor activity
I5M77_RS03020	COG1448	Aminotransferase
I5M77_RS03035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M77_RS03045	COG0017	Asparaginyl-tRNA synthetase
I5M77_RS03050	COG0840	transmembrane signaling receptor activity
I5M77_RS03055	COG0720	synthase
I5M77_RS03065	COG2200	EAL domain
I5M77_RS03070	COG1760	l-serine dehydratase
I5M77_RS03075	COG0814	amino acid
I5M77_RS03080	COG0494	nUDIX hydrolase
I5M77_RS03090	COG2205	protein histidine kinase activity
I5M77_RS03090	COG0784	Response regulator, receiver
I5M77_RS03095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5M77_RS03110	COG3106	COG3106 Predicted ATPase
I5M77_RS03115	COG3768	UPF0283 membrane protein
I5M77_RS03125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M77_RS03225	COG0251	oxidation-reduction process
I5M77_RS03310	COG2732	(Barnase) inhibitor
I5M77_RS03515	COG0251	oxidation-reduction process
I5M77_RS03705	COG1335	isochorismatase
I5M77_RS03710	COG0456	acetyltransferase
I5M77_RS03730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5M77_RS03795	COG1192	Involved in chromosome partitioning
I5M77_RS03885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5M77_RS04000	COG1280	lysine exporter protein (LysE YggA)
I5M77_RS04250	COG2801	Transposase and inactivated derivatives
I5M77_RS04295	COG1757	Na H antiporter
I5M77_RS04300	COG0174	glutamine synthetase
I5M77_RS04305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5M77_RS04310	COG1917	Cupin 2, conserved barrel domain protein
I5M77_RS04310	COG1396	sequence-specific DNA binding
I5M77_RS04315	COG1012	belongs to the aldehyde dehydrogenase family
I5M77_RS04320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M77_RS04330	COG2957	Belongs to the agmatine deiminase family
I5M77_RS04335	COG1012	belongs to the aldehyde dehydrogenase family
I5M77_RS04340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M77_RS04345	COG1227	inorganic diphosphatase activity
I5M77_RS04350	COG2771	luxR family
I5M77_RS04350	COG2200	EAL domain
I5M77_RS04360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5M77_RS04375	COG1846	Transcriptional regulator
I5M77_RS04380	COG2315	Protein conserved in bacteria
I5M77_RS04400	COG0110	maltose O-acetyltransferase activity
I5M77_RS04430	COG3063	Type IV pilus biogenesis stability protein PilW
I5M77_RS04435	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I5M77_RS04445	COG0531	amino acid
I5M77_RS04450	COG1560	Kdo2-lipid A biosynthetic process
I5M77_RS04455	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5M77_RS04460	COG1280	lysine exporter protein (LysE YggA)
I5M77_RS04470	COG1115	amino acid carrier protein
I5M77_RS04495	COG1368	sulfuric ester hydrolase activity
I5M77_RS04500	COG0642	Histidine kinase
I5M77_RS04505	COG0745	RESPONSE REGULATOR receiver
I5M77_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS04535	COG2113	Glycine betaine
I5M77_RS04540	COG4176	ABC-type proline glycine betaine transport system permease component
I5M77_RS04560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M77_RS04565	COG0456	acetyltransferase
I5M77_RS04570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M77_RS04575	COG0662	Cupin 2, conserved barrel domain protein
I5M77_RS04580	COG0527	aspartate kinase activity
I5M77_RS04585	COG1858	cytochrome C peroxidase
I5M77_RS04600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS04615	COG3290	protein histidine kinase activity
I5M77_RS04620	COG4565	transcriptional regulatory protein
I5M77_RS04755	COG1475	DNA binding
I5M77_RS04775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M77_RS04790	COG1783	phage Terminase large subunit
I5M77_RS04990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5M77_RS04995	COG0363	glucosamine-6-phosphate deaminase activity
I5M77_RS05000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I5M77_RS05030	COG3284	Transcriptional regulator
I5M77_RS05035	COG1012	belongs to the aldehyde dehydrogenase family
I5M77_RS05105	COG4669	(LipO)protein
I5M77_RS05135	COG3423	Transcriptional regulator
I5M77_RS05200	COG3012	SEC-C Motif Domain Protein
I5M77_RS05415	COG1073	alpha beta
I5M77_RS05420	COG1073	alpha beta
I5M77_RS05430	COG4792	protein secretion
I5M77_RS05435	COG4791	protein targeting
I5M77_RS05440	COG4794	Type iii secretion
I5M77_RS05445	COG4790	Type iii secretion
I5M77_RS05515	COG0457	Tetratricopeptide repeat
I5M77_RS05535	COG0730	response to heat
I5M77_RS05565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5M77_RS05570	COG0372	Belongs to the citrate synthase family
I5M77_RS05580	COG2828	Protein conserved in bacteria
I5M77_RS05605	COG0561	phosphatase activity
I5M77_RS05610	COG0602	queuosine metabolic process
I5M77_RS05615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I5M77_RS05620	COG3706	GGDEF domain
I5M77_RS05660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5M77_RS05665	COG0840	transmembrane signaling receptor activity
I5M77_RS05670	COG1254	Belongs to the acylphosphatase family
I5M77_RS05675	COG2920	part of a sulfur-relay system
I5M77_RS05685	COG0670	Belongs to the BI1 family
I5M77_RS05690	COG1126	abc transporter atp-binding protein
I5M77_RS05695	COG0765	amino acid transport
I5M77_RS05700	COG4597	amino acid ABC transporter
I5M77_RS05705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M77_RS05715	COG1666	GTP binding
I5M77_RS05720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M77_RS05740	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I5M77_RS05740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5M77_RS05745	COG3008	intermembrane lipid transfer
I5M77_RS05750	COG2995	paraquat-inducible protein a
I5M77_RS05755	COG1132	(ABC) transporter
I5M77_RS05760	COG1956	GAF domain-containing protein
I5M77_RS05765	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I5M77_RS05780	COG0308	aminopeptidase N
I5M77_RS05790	COG2902	Dehydrogenase
I5M77_RS05795	COG0167	dihydroorotate dehydrogenase activity
I5M77_RS05805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5M77_RS05805	COG0116	Belongs to the methyltransferase superfamily
I5M77_RS05815	COG0488	(ABC) transporter
I5M77_RS05830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5M77_RS05835	COG1067	ATP-dependent peptidase activity
I5M77_RS05840	COG3120	sequence-specific DNA binding
I5M77_RS05855	COG0784	Response regulator, receiver
I5M77_RS05855	COG2205	protein histidine kinase activity
I5M77_RS05870	COG3278	Belongs to the heme-copper respiratory oxidase family
I5M77_RS05885	COG2010	Cytochrome c
I5M77_RS05895	COG2217	Heavy metal translocating P-type atpase
I5M77_RS05910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M77_RS05915	COG0589	response to stress
I5M77_RS05920	COG0037	tRNA processing
I5M77_RS05940	COG3842	ATPase activity
I5M77_RS05950	COG1177	transmembrane transport
I5M77_RS05960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M77_RS05965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5M77_RS05975	COG0004	ammonium transporteR
I5M77_RS06000	COG0437	4 iron, 4 sulfur cluster binding
I5M77_RS06005	COG0243	molybdopterin cofactor binding
I5M77_RS06005	COG3383	formate dehydrogenase (NAD+) activity
I5M77_RS06015	COG3381	protein complex oligomerization
I5M77_RS06035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5M77_RS06040	COG0488	(ABC) transporter
I5M77_RS06045	COG4191	Histidine kinase
I5M77_RS06050	COG2204	response regulator
I5M77_RS06065	COG3842	ATPase activity
I5M77_RS06070	COG0746	molybdenum cofactor guanylyltransferase activity
I5M77_RS06075	COG0303	'Molybdopterin
I5M77_RS06085	COG1940	carbohydrate kinase activity
I5M77_RS06090	COG3148	PFAM DTW domain containing protein
I5M77_RS06130	COG0791	NLP P60 protein
I5M77_RS06140	COG3706	GGDEF domain
I5M77_RS06145	COG2201	protein-glutamate methylesterase activity
I5M77_RS06150	COG3001	Fructosamine kinase
I5M77_RS06160	COG0307	riboflavin synthase, alpha
I5M77_RS06165	COG0534	Mate efflux family protein
I5M77_RS06175	COG1793	dna ligase
I5M77_RS06205	COG2204	response regulator
I5M77_RS06245	COG0438	transferase activity, transferring glycosyl groups
I5M77_RS06250	COG1215	transferase activity, transferring glycosyl groups
I5M77_RS06255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5M77_RS06265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M77_RS06280	COG1643	Atp-dependent helicase
I5M77_RS06285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I5M77_RS06300	COG3302	dmso reductase anchor subunit
I5M77_RS06305	COG0437	4 iron, 4 sulfur cluster binding
I5M77_RS06310	COG0243	molybdopterin cofactor binding
I5M77_RS06350	COG0443	Heat shock 70 kDa protein
I5M77_RS06355	COG0443	Heat shock 70 kDa protein
I5M77_RS06380	COG1132	(ABC) transporter
I5M77_RS06385	COG1132	(ABC) transporter
I5M77_RS06405	COG0814	amino acid
I5M77_RS06415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5M77_RS06495	COG1522	sequence-specific DNA binding
I5M77_RS06530	COG0515	serine threonine protein kinase
I5M77_RS06555	COG3501	Rhs element vgr protein
I5M77_RS06575	COG2885	chlorophyll binding
I5M77_RS06595	COG0739	heme binding
I5M77_RS06600	COG0861	Integral membrane protein TerC family
I5M77_RS06610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M77_RS06615	COG1328	CTP reductase activity
I5M77_RS06620	COG1280	lysine exporter protein (LysE YggA)
I5M77_RS06630	COG5001	Diguanylate cyclase
I5M77_RS06630	COG3300	MHYT domain
I5M77_RS06640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M77_RS06640	COG4191	Histidine kinase
I5M77_RS06645	COG0471	metal ion transport
I5M77_RS06680	COG0583	DNA-binding transcription factor activity
I5M77_RS06685	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5M77_RS06745	COG0625	glutathione transferase activity
I5M77_RS06755	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I5M77_RS06765	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5M77_RS06775	COG0601	transmembrane transport
I5M77_RS06780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M77_RS06785	COG0444	Belongs to the ABC transporter superfamily
I5M77_RS06800	COG3291	Pkd domain containing protein
I5M77_RS06810	COG1177	transmembrane transport
I5M77_RS06815	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M77_RS06820	COG3842	ATPase activity
I5M77_RS06825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5M77_RS06830	COG2423	ornithine cyclodeaminase activity
I5M77_RS06845	COG3938	Belongs to the proline racemase family
I5M77_RS06875	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I5M77_RS06880	COG1451	nucleotide metabolic process
I5M77_RS06890	COG0583	DNA-binding transcription factor activity
I5M77_RS06910	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I5M77_RS06915	COG4139	cobalamin transport
I5M77_RS06920	COG2988	succinylglutamate desuccinylase activity
I5M77_RS06930	COG2062	phosphohistidine phosphatase, SixA
I5M77_RS06940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I5M77_RS06945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I5M77_RS06950	COG0702	epimerase
I5M77_RS06955	COG1823	symporter activity
I5M77_RS06960	COG2925	Exonuclease
I5M77_RS06965	COG1380	Effector of murein hydrolase LrgA
I5M77_RS06970	COG1346	cytolysis
I5M77_RS06975	COG0295	cytidine deaminase activity
I5M77_RS06980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I5M77_RS06985	COG0500	methyltransferase
I5M77_RS06995	COG0776	regulation of translation
I5M77_RS07005	COG0072	phenylalanine-tRNA ligase activity
I5M77_RS07005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M77_RS07010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I5M77_RS07015	COG3706	GGDEF domain
I5M77_RS07045	COG0393	Putative heavy-metal-binding
I5M77_RS07055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I5M77_RS07065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5M77_RS07080	COG2188	Transcriptional regulator
I5M77_RS07085	COG1228	amidohydrolase
I5M77_RS07090	COG0010	Belongs to the arginase family
I5M77_RS07095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I5M77_RS07100	COG2986	histidine ammonia-lyase
I5M77_RS07115	COG0247	lactate metabolic process
I5M77_RS07115	COG0277	FAD linked oxidase domain protein
I5M77_RS07150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I5M77_RS07165	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I5M77_RS07170	COG1643	Atp-dependent helicase
I5M77_RS07175	COG0281	malic enzyme
I5M77_RS07180	COG2949	membrane
I5M77_RS07185	COG0471	metal ion transport
I5M77_RS07210	COG0492	ferredoxin-NADP+ reductase activity
I5M77_RS07215	COG4988	ABC transporter
I5M77_RS07220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5M77_RS07225	COG3048	D-serine ammonia-lyase activity
I5M77_RS07230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I5M77_RS07240	COG4191	Histidine kinase
I5M77_RS07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M77_RS07255	COG3070	regulator of competence-specific genes
I5M77_RS07265	COG2431	L-lysine efflux transmembrane transporter activity
I5M77_RS07275	COG0076	glutamate decarboxylase activity
I5M77_RS07280	COG1737	Transcriptional regulator
I5M77_RS07290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M77_RS07295	COG3273	potassium ion transport
I5M77_RS07295	COG2985	domain, Protein
I5M77_RS07300	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5M77_RS07315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5M77_RS07330	COG4181	ATPase activity
I5M77_RS07335	COG0534	Mate efflux family protein
I5M77_RS07340	COG0702	epimerase
I5M77_RS07345	COG3005	denitrification pathway
I5M77_RS07375	COG2814	Major facilitator Superfamily
I5M77_RS07380	COG1187	pseudouridine synthase activity
I5M77_RS07385	COG1061	Type III restriction enzyme res subunit
I5M77_RS07405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I5M77_RS07430	COG3313	Fe-S protein
I5M77_RS07455	COG0493	'glutamate synthase
I5M77_RS07465	COG0398	Pfam SNARE associated Golgi protein
I5M77_RS07470	COG4134	Bacterial extracellular solute-binding protein
I5M77_RS07475	COG4135	transport system, permease component
I5M77_RS07480	COG4136	ATPase activity
I5M77_RS07485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5M77_RS07495	COG3604	Transcriptional regulator
I5M77_RS07500	COG1151	hydroxylamine reductase activity
I5M77_RS07505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M77_RS07515	COG0564	pseudouridine synthase activity
I5M77_RS07525	COG0733	neurotransmitter:sodium symporter activity
I5M77_RS07535	COG0626	cystathionine gamma-synthase activity
I5M77_RS07540	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I5M77_RS07545	COG5380	lipid catabolic process
I5M77_RS07550	COG2818	Glycosylase
I5M77_RS07565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS07570	COG1983	PspC domain protein
I5M77_RS07580	COG1842	Phage shock protein A
I5M77_RS07585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M77_RS07600	COG4171	peptide transport system, permease
I5M77_RS07610	COG4172	Belongs to the ABC transporter superfamily
I5M77_RS07620	COG1227	inorganic diphosphatase activity
I5M77_RS07635	COG0243	molybdopterin cofactor binding
I5M77_RS07640	COG3005	denitrification pathway
I5M77_RS07645	COG4459	periplasmic nitrate reductase
I5M77_RS07650	COG0390	transport system, permease component
I5M77_RS07660	COG2116	formate transmembrane transporter activity
I5M77_RS07685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M77_RS07690	COG1435	thymidine kinase activity
I5M77_RS07695	COG0215	cysteine-tRNA ligase activity
I5M77_RS07700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5M77_RS07705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5M77_RS07710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I5M77_RS07715	COG3012	SEC-C Motif Domain Protein
I5M77_RS07720	COG0140	phosphoribosyl-ATP diphosphatase activity
I5M77_RS07720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I5M77_RS07725	COG0107	imidazoleglycerol-phosphate synthase activity
I5M77_RS07730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I5M77_RS07735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5M77_RS07740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5M77_RS07740	COG0131	Imidazoleglycerol-phosphate dehydratase
I5M77_RS07745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5M77_RS07750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I5M77_RS07755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I5M77_RS07770	COG1757	Na H antiporter
I5M77_RS07780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M77_RS07790	COG0482	sulfurtransferase activity
I5M77_RS07795	COG2915	High frequency lysogenization protein hflD homolog
I5M77_RS07800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5M77_RS07820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M77_RS07835	COG0300	oxidoreductase activity
I5M77_RS07845	COG0501	Belongs to the peptidase M48B family
I5M77_RS07855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5M77_RS07865	COG0156	8-amino-7-oxononanoate synthase activity
I5M77_RS07870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I5M77_RS07875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M77_RS07880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5M77_RS07895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I5M77_RS07900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5M77_RS07905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I5M77_RS07910	COG1674	ftsk spoiiie
I5M77_RS07920	COG0686	Belongs to the AlaDH PNT family
I5M77_RS07930	COG0583	DNA-binding transcription factor activity
I5M77_RS07980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M77_RS07985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS07990	COG0840	transmembrane signaling receptor activity
I5M77_RS08065	COG5002	protein histidine kinase activity
I5M77_RS08065	COG0784	Response regulator, receiver
I5M77_RS08075	COG0754	glutathionylspermidine amidase activity
I5M77_RS08095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5M77_RS08100	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5M77_RS08105	COG2885	chlorophyll binding
I5M77_RS08110	COG0823	Involved in the tonB-independent uptake of proteins
I5M77_RS08125	COG0811	peptide transport
I5M77_RS08130	COG0824	Thioesterase
I5M77_RS08140	COG4890	Cyd operon protein YbgT
I5M77_RS08145	COG1294	oxidase, subunit
I5M77_RS08150	COG1271	oxidase subunit
I5M77_RS08155	COG2255	four-way junction helicase activity
I5M77_RS08160	COG0632	four-way junction helicase activity
I5M77_RS08165	COG0840	transmembrane signaling receptor activity
I5M77_RS08170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I5M77_RS08175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I5M77_RS08180	COG1801	Protein of unknown function DUF72
I5M77_RS08185	COG4106	trans-aconitate 2-methyltransferase activity
I5M77_RS08190	COG0500	methyltransferase
I5M77_RS08195	COG4067	protein conserved in archaea
I5M77_RS08195	COG0189	ligase activity
I5M77_RS08215	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I5M77_RS08220	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I5M77_RS08225	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I5M77_RS08230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5M77_RS08235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M77_RS08240	COG0745	RESPONSE REGULATOR receiver
I5M77_RS08245	COG3381	protein complex oligomerization
I5M77_RS08250	COG1609	Transcriptional regulator
I5M77_RS08255	COG3070	regulator of competence-specific genes
I5M77_RS08275	COG0297	glycogen (starch) synthase activity
I5M77_RS08280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I5M77_RS08285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M77_RS08295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5M77_RS08305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I5M77_RS08310	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I5M77_RS08315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5M77_RS08325	COG0542	response to heat
I5M77_RS08330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I5M77_RS08335	COG1278	Cold shock
I5M77_RS08345	COG1187	pseudouridine synthase activity
I5M77_RS08350	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I5M77_RS08360	COG1199	ATP-dependent helicase activity
I5M77_RS08365	COG0730	response to heat
I5M77_RS08370	COG3923	Primosomal replication protein n
I5M77_RS08380	COG0708	Exodeoxyribonuclease III
I5M77_RS08420	COG1882	Formate acetyltransferase
I5M77_RS08430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M77_RS08440	COG3013	Belongs to the UPF0304 family
I5M77_RS08445	COG2766	serine protein kinase
I5M77_RS08450	COG2718	Belongs to the UPF0229 family
I5M77_RS08455	COG2719	SpoVR family
I5M77_RS08460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I5M77_RS08470	COG1663	tetraacyldisaccharide 4'-kinase activity
I5M77_RS08475	COG1132	(ABC) transporter
I5M77_RS08480	COG2333	competence protein COMEC
I5M77_RS08480	COG0658	competence protein
I5M77_RS08490	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M77_RS08495	COG1136	(ABC) transporter
I5M77_RS08500	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M77_RS08510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5M77_RS08525	COG1252	NADH dehydrogenase
I5M77_RS08530	COG3150	esterase
I5M77_RS08555	COG0537	adenosine 5'-monophosphoramidase activity
I5M77_RS08580	COG0516	GMP reductase activity
I5M77_RS08580	COG0517	IMP dehydrogenase activity
I5M77_RS08585	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I5M77_RS08590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I5M77_RS08595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M77_RS08650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5M77_RS08715	COG2199	diguanylate cyclase activity
I5M77_RS08730	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I5M77_RS08735	COG1946	Acyl-CoA thioesterase
I5M77_RS08745	COG1522	sequence-specific DNA binding
I5M77_RS08770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M77_RS08820	COG0477	Major facilitator Superfamily
I5M77_RS08825	COG2855	membrane
I5M77_RS08845	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I5M77_RS08850	COG0596	Alpha beta hydrolase
I5M77_RS08855	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I5M77_RS08860	COG1169	isochorismate synthase
I5M77_RS08865	COG0436	Aminotransferase
I5M77_RS08870	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I5M77_RS08875	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I5M77_RS08890	COG1555	photosystem II stabilization
I5M77_RS08895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M77_RS08900	COG0776	regulation of translation
I5M77_RS08905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5M77_RS08910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5M77_RS08920	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5M77_RS08935	COG2204	response regulator
I5M77_RS08945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I5M77_RS08950	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I5M77_RS08955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I5M77_RS08960	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I5M77_RS08975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5M77_RS08980	COG0569	domain protein
I5M77_RS08985	COG0513	Belongs to the DEAD box helicase family
I5M77_RS08990	COG1253	flavin adenine dinucleotide binding
I5M77_RS09025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5M77_RS09030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5M77_RS09045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5M77_RS09050	COG1216	Glycosyl transferase, family 2
I5M77_RS09055	COG2986	histidine ammonia-lyase
I5M77_RS09080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M77_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS09110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5M77_RS09115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M77_RS09120	COG0583	DNA-binding transcription factor activity
I5M77_RS09125	COG2951	lytic endotransglycosylase activity
I5M77_RS09130	COG3100	YcgL domain-containing protein
I5M77_RS09135	COG0850	regulation of cytokinetic process
I5M77_RS09140	COG2894	cell division
I5M77_RS09145	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I5M77_RS09150	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I5M77_RS09155	COG0318	PFAM AMP-dependent synthetase and ligase
I5M77_RS09160	COG2267	carboxylic ester hydrolase activity
I5M77_RS09175	COG1214	PFAM Peptidase M22, glycoprotease
I5M77_RS09180	COG1199	ATP-dependent helicase activity
I5M77_RS09185	COG0788	formyltetrahydrofolate deformylase activity
I5M77_RS09190	COG3102	Protein conserved in bacteria
I5M77_RS09195	COG0018	arginyl-trna synthetase
I5M77_RS09215	COG1918	ferrous iron import across plasma membrane
I5M77_RS09220	COG4977	sequence-specific DNA binding
I5M77_RS09225	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5M77_RS09230	COG1121	(ABC) transporter
I5M77_RS09235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M77_RS09245	COG0045	succinate-CoA ligase (ADP-forming) activity
I5M77_RS09250	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M77_RS09255	COG0567	Dehydrogenase, E1 component
I5M77_RS09260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M77_RS09265	COG1053	succinate dehydrogenase
I5M77_RS09270	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5M77_RS09285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I5M77_RS09295	COG0033	Phosphoglucomutase
I5M77_RS09300	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I5M77_RS09305	COG0596	Alpha beta hydrolase
I5M77_RS09325	COG0735	belongs to the Fur family
I5M77_RS09330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5M77_RS09335	COG1263	PTS System
I5M77_RS09335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M77_RS09340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5M77_RS09345	COG1940	carbohydrate kinase activity
I5M77_RS09345	COG1846	Transcriptional regulator
I5M77_RS09350	COG4651	solute:proton antiporter activity
I5M77_RS09350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5M77_RS09355	COG0367	asparagine synthase
I5M77_RS09360	COG0250	Participates in transcription elongation, termination and antitermination
I5M77_RS09365	COG3104	oligopeptide transport
I5M77_RS09370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I5M77_RS09375	COG0563	adenylate kinase activity
I5M77_RS09380	COG0326	Molecular chaperone. Has ATPase activity
I5M77_RS09385	COG3710	Transcriptional regulator
I5M77_RS09405	COG0622	Phosphoesterase
I5M77_RS09430	COG1090	epimerase
I5M77_RS09435	COG0300	oxidoreductase activity
I5M77_RS09440	COG3118	belongs to the thioredoxin family
I5M77_RS09445	COG0330	HflC and HflK could
I5M77_RS09465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5M77_RS09470	COG3115	cell septum assembly
I5M77_RS09475	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I5M77_RS09480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5M77_RS09485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M77_RS09490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5M77_RS09495	COG2190	(PTS) system
I5M77_RS09500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS09505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS09510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS09515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS09525	COG1705	Flagellar rod assembly protein muramidase FlgJ
I5M77_RS09525	COG3951	Flagellar rod assembly protein muramidase FlgJ
I5M77_RS09530	COG1706	bacterial-type flagellum-dependent cell motility
I5M77_RS09535	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I5M77_RS09545	COG4787	bacterial-type flagellum-dependent cell motility
I5M77_RS09550	COG1749	Flagellar hook protein flgE
I5M77_RS09560	COG1558	bacterial-type flagellum-dependent cell motility
I5M77_RS09565	COG1815	bacterial-type flagellum-dependent cell motility
I5M77_RS09570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5M77_RS09575	COG0784	Response regulator, receiver
I5M77_RS09575	COG0835	chemotaxis
I5M77_RS09625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5M77_RS09630	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I5M77_RS09640	COG2217	Heavy metal translocating P-type atpase
I5M77_RS09640	COG2608	mercury ion transmembrane transporter activity
I5M77_RS09675	COG2840	Smr protein MutS2
I5M77_RS09680	COG1187	pseudouridine synthase activity
I5M77_RS09690	COG0737	Belongs to the 5'-nucleotidase family
I5M77_RS09695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I5M77_RS09700	COG2912	Transglutaminase-like superfamily
I5M77_RS09705	COG3094	Invasion gene expression up-regulator, SirB
I5M77_RS09710	COG2890	protein-(glutamine-N5) methyltransferase activity
I5M77_RS09715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I5M77_RS09720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I5M77_RS09725	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I5M77_RS09730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I5M77_RS09735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5M77_RS09740	COG0193	aminoacyl-tRNA hydrolase activity
I5M77_RS09745	COG0012	GTP binding
I5M77_RS09860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M77_RS09865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5M77_RS09870	COG1702	phosphate starvation-inducible protein PhoH
I5M77_RS09875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I5M77_RS09880	COG4535	Mg2 and Co2 transporter CorC
I5M77_RS09885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I5M77_RS09890	COG2888	peptidyl-tyrosine sulfation
I5M77_RS09895	COG0495	leucyl-tRNA aminoacylation
I5M77_RS09900	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I5M77_RS09905	COG1466	dna polymerase III delta subunit
I5M77_RS09910	COG0799	negative regulation of ribosome biogenesis
I5M77_RS09915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I5M77_RS09920	COG0768	penicillin binding
I5M77_RS09925	COG0772	Belongs to the SEDS family
I5M77_RS09930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M77_RS09935	COG1686	Belongs to the peptidase S11 family
I5M77_RS09940	COG2921	Belongs to the UPF0250 family
I5M77_RS09945	COG0321	lipoyl(octanoyl) transferase activity
I5M77_RS09950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5M77_RS09955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5M77_RS09960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5M77_RS09975	COG0366	Alpha amylase catalytic
I5M77_RS09980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M77_RS09980	COG1263	PTS System
I5M77_RS09990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5M77_RS09995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5M77_RS10000	COG2011	ABC-type metal ion transport system permease component
I5M77_RS10005	COG1464	Belongs to the NlpA lipoprotein family
I5M77_RS10010	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I5M77_RS10020	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I5M77_RS10020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I5M77_RS10035	COG1611	Belongs to the LOG family
I5M77_RS10040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5M77_RS10050	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I5M77_RS10055	COG2363	Small membrane protein
I5M77_RS10065	COG0583	DNA-binding transcription factor activity
I5M77_RS10070	COG0301	tRNA thio-modification
I5M77_RS10070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M77_RS10075	COG2885	chlorophyll binding
I5M77_RS10080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I5M77_RS10085	COG1722	exodeoxyribonuclease VII activity
I5M77_RS10090	COG0142	geranyltranstransferase activity
I5M77_RS10095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I5M77_RS10100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5M77_RS10105	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I5M77_RS10110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5M77_RS10130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M77_RS10130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M77_RS10135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5M77_RS10140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I5M77_RS10145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I5M77_RS10155	COG1073	alpha beta
I5M77_RS10160	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I5M77_RS10165	COG2252	PERMEase
I5M77_RS10170	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5M77_RS10195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5M77_RS10195	COG0047	phosphoribosylformylglycinamidine synthase activity
I5M77_RS10200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5M77_RS10210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5M77_RS10240	COG0484	heat shock protein binding
I5M77_RS10245	COG0443	Heat shock 70 kDa protein
I5M77_RS10255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5M77_RS10260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5M77_RS10270	COG0497	DNA recombination
I5M77_RS10275	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M77_RS10280	COG2914	Belongs to the UPF0125 (RnfH) family
I5M77_RS10285	COG2867	negative regulation of translational initiation
I5M77_RS10290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I5M77_RS10300	COG0582	viral genome integration into host DNA
I5M77_RS10345	COG3501	Rhs element vgr protein
I5M77_RS10365	COG0582	viral genome integration into host DNA
I5M77_RS10390	COG4580	involved in the transport of maltose and maltodextrins
I5M77_RS10395	COG1874	Beta-galactosidase
I5M77_RS10405	COG3833	ABC-type maltose transport systems, permease component
I5M77_RS10410	COG1175	transmembrane transport
I5M77_RS10415	COG2182	Extracellular solute-binding protein
I5M77_RS10425	COG1609	Transcriptional regulator
I5M77_RS10435	COG3293	Transposase
I5M77_RS10490	COG2003	Belongs to the UPF0758 family
I5M77_RS10530	COG0583	DNA-binding transcription factor activity
I5M77_RS10535	COG3153	acetyltransferase
I5M77_RS10535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M77_RS10555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M77_RS10560	COG2873	o-acetylhomoserine
I5M77_RS10590	COG1115	amino acid carrier protein
I5M77_RS10600	COG1584	GPR1 FUN34 yaaH family protein
I5M77_RS10610	COG1757	Na H antiporter
I5M77_RS10615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5M77_RS10615	COG0519	Catalyzes the synthesis of GMP from XMP
I5M77_RS10620	COG0517	IMP dehydrogenase activity
I5M77_RS10620	COG0516	GMP reductase activity
I5M77_RS10625	COG1570	exodeoxyribonuclease VII activity
I5M77_RS10640	COG1160	GTP binding
I5M77_RS10645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M77_RS10650	COG2976	Protein conserved in bacteria
I5M77_RS10655	COG0124	histidyl-tRNA synthetase
I5M77_RS10660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I5M77_RS10670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5M77_RS10675	COG0105	UTP biosynthetic process
I5M77_RS10680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5M77_RS10685	COG2975	iron-sulfur cluster assembly
I5M77_RS10690	COG0633	Ferredoxin
I5M77_RS10695	COG0443	Heat shock 70 kDa protein
I5M77_RS10700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5M77_RS10710	COG0822	iron-sulfur transferase activity
I5M77_RS10715	COG1104	cysteine desulfurase activity
I5M77_RS10730	COG0483	inositol monophosphate 1-phosphatase activity
I5M77_RS10735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M77_RS10740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M77_RS10745	COG1862	Preprotein translocase
I5M77_RS10750	COG0343	queuine tRNA-ribosyltransferase activity
I5M77_RS10755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5M77_RS10765	COG0517	IMP dehydrogenase activity
I5M77_RS10775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5M77_RS10780	COG0583	DNA-binding transcription factor activity
I5M77_RS10785	COG0450	alkyl hydroperoxide reductase
I5M77_RS10790	COG3142	Participates in the control of copper homeostasis
I5M77_RS10800	COG0704	Plays a role in the regulation of phosphate uptake
I5M77_RS10805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5M77_RS10810	COG0581	inorganic phosphate transmembrane transporter activity
I5M77_RS10820	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I5M77_RS10825	COG0248	Ppx GppA phosphatase
I5M77_RS10835	COG5002	protein histidine kinase activity
I5M77_RS10840	COG0745	RESPONSE REGULATOR receiver
I5M77_RS10845	COG2974	May be involved in recombination
I5M77_RS10850	COG0826	peptidase U32
I5M77_RS10855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M77_RS10910	COG0542	response to heat
I5M77_RS10920	COG0564	pseudouridine synthase activity
I5M77_RS10925	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M77_RS10930	COG1196	nuclear chromosome segregation
I5M77_RS10930	COG0741	lytic transglycosylase activity
I5M77_RS10930	COG0739	heme binding
I5M77_RS10935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M77_RS10940	COG0077	Prephenate dehydratase
I5M77_RS10940	COG1605	Chorismate mutase
I5M77_RS10945	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I5M77_RS10950	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I5M77_RS10960	COG0488	(ABC) transporter
I5M77_RS10970	COG0739	heme binding
I5M77_RS10975	COG0287	Prephenate dehydrogenase
I5M77_RS10975	COG1605	Chorismate mutase
I5M77_RS10980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M77_RS10985	COG1472	Belongs to the glycosyl hydrolase 3 family
I5M77_RS10990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I5M77_RS10995	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I5M77_RS11010	COG1966	Carbon starvation protein
I5M77_RS11015	COG3275	phosphorelay sensor kinase activity
I5M77_RS11020	COG3279	Response regulator of the LytR AlgR family
I5M77_RS11025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I5M77_RS11030	COG1047	Peptidyl-prolyl cis-trans
I5M77_RS11035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5M77_RS11040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I5M77_RS11045	COG0196	riboflavin kinase activity
I5M77_RS11050	COG0728	peptidoglycan biosynthetic process
I5M77_RS11055	COG0268	Binds directly to 16S ribosomal RNA
I5M77_RS11060	COG0640	Transcriptional regulator
I5M77_RS11065	COG0583	DNA-binding transcription factor activity
I5M77_RS11070	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5M77_RS11080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I5M77_RS11085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I5M77_RS11090	COG0730	response to heat
I5M77_RS11100	COG0494	nUDIX hydrolase
I5M77_RS11105	COG3066	DNA modification
I5M77_RS11115	COG0667	Aldo Keto reductase
I5M77_RS11130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I5M77_RS11140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5M77_RS11145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M77_RS11150	COG4974	Belongs to the 'phage' integrase family
I5M77_RS11155	COG0716	FMN binding
I5M77_RS11165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I5M77_RS11170	COG0513	Belongs to the DEAD box helicase family
I5M77_RS11175	COG3022	response to hydroperoxide
I5M77_RS11180	COG1115	amino acid carrier protein
I5M77_RS11195	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I5M77_RS11200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I5M77_RS11205	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I5M77_RS11210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5M77_RS11215	COG0083	homoserine kinase activity
I5M77_RS11230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5M77_RS11240	COG0745	RESPONSE REGULATOR receiver
I5M77_RS11250	COG5002	protein histidine kinase activity
I5M77_RS11250	COG0784	Response regulator, receiver
I5M77_RS11250	COG2198	Histidine kinase
I5M77_RS11255	COG2203	Gaf domain
I5M77_RS11255	COG4251	negative regulation of phosphorylation
I5M77_RS11255	COG5001	Diguanylate cyclase
I5M77_RS11255	COG3706	GGDEF domain
I5M77_RS11260	COG1242	4 iron, 4 sulfur cluster binding
I5M77_RS11265	COG0067	glutamate synthase
I5M77_RS11265	COG0070	glutamate synthase
I5M77_RS11265	COG0069	glutamate synthase activity
I5M77_RS11275	COG0070	glutamate synthase
I5M77_RS11275	COG0069	glutamate synthase activity
I5M77_RS11275	COG0067	glutamate synthase
I5M77_RS11280	COG0493	'glutamate synthase
I5M77_RS11290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5M77_RS11300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M77_RS11305	COG2860	membrane
I5M77_RS11310	COG0583	DNA-binding transcription factor activity
I5M77_RS11315	COG0730	response to heat
I5M77_RS11330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I5M77_RS11335	COG0505	Belongs to the CarA family
I5M77_RS11340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I5M77_RS11345	COG0494	nUDIX hydrolase
I5M77_RS11350	COG0653	protein targeting
I5M77_RS11360	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I5M77_RS11365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5M77_RS11370	COG0849	cell division
I5M77_RS11375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I5M77_RS11380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5M77_RS11385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5M77_RS11390	COG0772	Belongs to the SEDS family
I5M77_RS11395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I5M77_RS11400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5M77_RS11405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5M77_RS11410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5M77_RS11415	COG0768	penicillin binding
I5M77_RS11420	COG3116	cell division
I5M77_RS11425	COG0275	rRNA processing
I5M77_RS11435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5M77_RS11445	COG0792	nuclease activity
I5M77_RS11450	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I5M77_RS11455	COG2823	Periplasmic or secreted lipoprotein
I5M77_RS11460	COG2969	positive regulation of protein catabolic process
I5M77_RS11465	COG0625	glutathione transferase activity
I5M77_RS11470	COG2857	Cytochrome c1
I5M77_RS11475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I5M77_RS11480	COG0723	plastoquinol--plastocyanin reductase activity
I5M77_RS11485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I5M77_RS11490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I5M77_RS11495	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M77_RS11500	COG3105	Protein conserved in bacteria
I5M77_RS11510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M77_RS11515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5M77_RS11525	COG3150	esterase
I5M77_RS11535	COG3151	Protein conserved in bacteria
I5M77_RS11540	COG0494	nUDIX hydrolase
I5M77_RS11545	COG1538	Outer membrane efflux protein
I5M77_RS11550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5M77_RS11550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I5M77_RS11555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I5M77_RS11570	COG3025	triphosphatase activity
I5M77_RS11575	COG1392	Phosphate transport regulator
I5M77_RS11580	COG0306	phosphate transporter
I5M77_RS11585	COG4991	sh3 domain protein
I5M77_RS11595	COG3409	Peptidoglycan-binding domain 1 protein
I5M77_RS11595	COG3267	Type II secretory pathway component ExeA
I5M77_RS11600	COG0617	tRNA 3'-terminal CCA addition
I5M77_RS11605	COG1968	undecaprenyl-diphosphatase activity
I5M77_RS11610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5M77_RS11615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M77_RS11620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I5M77_RS11625	COG0596	Alpha beta hydrolase
I5M77_RS11630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I5M77_RS11635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5M77_RS11640	COG1610	YqeY-like protein
I5M77_RS11645	COG0358	DNA primase activity
I5M77_RS11745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5M77_RS11795	COG0732	type I restriction modification DNA specificity domain
I5M77_RS11840	COG1464	Belongs to the NlpA lipoprotein family
I5M77_RS11870	COG2213	PTS system mannitol-specific
I5M77_RS11870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M77_RS11875	COG0246	Mannitol dehydrogenase
I5M77_RS11880	COG3722	fumarate hydratase activity
I5M77_RS11885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M77_RS11890	COG5002	protein histidine kinase activity
I5M77_RS11905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M77_RS11910	COG1349	DNA-binding transcription factor activity
I5M77_RS11915	COG0469	pyruvate kinase activity
I5M77_RS11930	COG0440	acetolactate synthase activity
I5M77_RS11935	COG0028	Belongs to the TPP enzyme family
I5M77_RS11940	COG1022	Amp-dependent synthetase and ligase
I5M77_RS11945	COG0583	DNA-binding transcription factor activity
I5M77_RS11965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5M77_RS11970	COG0473	3-isopropylmalate dehydrogenase activity
I5M77_RS11975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5M77_RS11980	COG0066	3-isopropylmalate dehydratase activity
I5M77_RS11990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5M77_RS11995	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I5M77_RS12000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M77_RS12005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5M77_RS12010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5M77_RS12015	COG2967	ApaG domain
I5M77_RS12020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5M77_RS12035	COG2966	Psort location CytoplasmicMembrane, score
I5M77_RS12040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I5M77_RS12050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I5M77_RS12055	COG0142	geranyltranstransferase activity
I5M77_RS12065	COG0039	L-malate dehydrogenase activity
I5M77_RS12075	COG2358	TRAP transporter, solute receptor (TAXI family
I5M77_RS12090	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I5M77_RS12095	COG1178	ABC-type Fe3 transport system permease component
I5M77_RS12100	COG4143	(ABC) transporter
I5M77_RS12105	COG0163	prenyltransferase activity
I5M77_RS12110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5M77_RS12115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I5M77_RS12120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I5M77_RS12130	COG2105	PFAM AIG2 family protein
I5M77_RS12140	COG0729	surface antigen
I5M77_RS12145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5M77_RS12155	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I5M77_RS12170	COG4181	ATPase activity
I5M77_RS12190	COG0529	Catalyzes the synthesis of activated sulfate
I5M77_RS12195	COG3273	potassium ion transport
I5M77_RS12195	COG0471	metal ion transport
I5M77_RS12200	COG2895	sulfate adenylyltransferase (ATP) activity
I5M77_RS12205	COG0175	sulfate reduction
I5M77_RS12210	COG1648	precorrin-2 dehydrogenase activity
I5M77_RS12210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I5M77_RS12215	COG0737	Belongs to the 5'-nucleotidase family
I5M77_RS12225	COG0513	Belongs to the DEAD box helicase family
I5M77_RS12230	COG2153	protein acetylation
I5M77_RS12240	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M77_RS12250	COG0203	ribosomal protein L17
I5M77_RS12255	COG0202	RNA polymerase activity
I5M77_RS12265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I5M77_RS12270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I5M77_RS12275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I5M77_RS12280	COG0201	protein transport
I5M77_RS12285	COG0200	Binds to the 23S rRNA
I5M77_RS12290	COG1841	ribosomal large subunit assembly
I5M77_RS12305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I5M77_RS12310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I5M77_RS12315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5M77_RS12320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I5M77_RS12325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I5M77_RS12330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I5M77_RS12335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I5M77_RS12340	COG0255	Belongs to the universal ribosomal protein uL29 family
I5M77_RS12350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I5M77_RS12355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5M77_RS12360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5M77_RS12365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I5M77_RS12375	COG0088	Forms part of the polypeptide exit tunnel
I5M77_RS12380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I5M77_RS12390	COG0254	rRNA binding
I5M77_RS12395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5M77_RS12400	COG1609	Transcriptional regulator
I5M77_RS12410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I5M77_RS12415	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I5M77_RS12430	COG2003	Belongs to the UPF0758 family
I5M77_RS12460	COG1575	Belongs to the MenA family. Type 1 subfamily
I5M77_RS12465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5M77_RS12470	COG3074	FtsZ-dependent cytokinesis
I5M77_RS12475	COG1494	fructose-1,6-bisphosphatase
I5M77_RS12500	COG0149	triose-phosphate isomerase activity
I5M77_RS12510	COG2801	Transposase and inactivated derivatives
I5M77_RS12555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5M77_RS12575	COG0438	transferase activity, transferring glycosyl groups
I5M77_RS12595	COG1215	transferase activity, transferring glycosyl groups
I5M77_RS12600	COG0110	maltose O-acetyltransferase activity
I5M77_RS12610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5M77_RS12660	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M77_RS12670	COG1560	Kdo2-lipid A biosynthetic process
I5M77_RS12675	COG0859	PFAM glycosyl transferase family 9
I5M77_RS12680	COG1519	Transferase
I5M77_RS12690	COG0297	glycogen (starch) synthase activity
I5M77_RS12690	COG0438	transferase activity, transferring glycosyl groups
I5M77_RS12710	COG2030	dehydratase
I5M77_RS12715	COG0110	maltose O-acetyltransferase activity
I5M77_RS12735	COG3642	lipopolysaccharide core region biosynthetic process
I5M77_RS12740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5M77_RS12745	COG0859	PFAM glycosyl transferase family 9
I5M77_RS12750	COG0463	Glycosyl transferase, family 2
I5M77_RS12755	COG0438	transferase activity, transferring glycosyl groups
I5M77_RS12770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5M77_RS12785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5M77_RS12790	COG2003	Belongs to the UPF0758 family
I5M77_RS12800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5M77_RS12805	COG1309	transcriptional regulator
I5M77_RS12810	COG1560	Kdo2-lipid A biosynthetic process
I5M77_RS12815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I5M77_RS12820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I5M77_RS12825	COG1561	YicC-like family, N-terminal region
I5M77_RS12885	COG4608	Belongs to the ABC transporter superfamily
I5M77_RS12890	COG0444	Belongs to the ABC transporter superfamily
I5M77_RS12895	COG0747	negative chemotaxis
I5M77_RS12900	COG4239	(ABC) transporter, permease
I5M77_RS12905	COG4174	ABC transporter (Permease)
I5M77_RS12925	COG0811	peptide transport
I5M77_RS12930	COG0848	biopolymer transport protein
I5M77_RS12945	COG0194	GDP metabolic process
I5M77_RS12950	COG1758	RNA polymerase activity
I5M77_RS12955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M77_RS12960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M77_RS12965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5M77_RS12970	COG2233	PERMEase
I5M77_RS12990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M77_RS13000	COG2183	response to ionizing radiation
I5M77_RS13010	COG0596	Alpha beta hydrolase
I5M77_RS13015	COG1040	competence protein
I5M77_RS13020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I5M77_RS13020	COG0316	Belongs to the HesB IscA family
I5M77_RS13025	COG0494	nUDIX hydrolase
I5M77_RS13030	COG1218	3'(2'),5'-bisphosphate nucleotidase
I5M77_RS13040	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I5M77_RS13045	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I5M77_RS13050	COG3156	type II secretion system protein K
I5M77_RS13055	COG4795	General secretion pathway protein
I5M77_RS13060	COG2165	general secretion pathway protein
I5M77_RS13065	COG2165	general secretion pathway protein
I5M77_RS13070	COG2165	general secretion pathway protein
I5M77_RS13075	COG1459	type II secretion system
I5M77_RS13080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5M77_RS13090	COG3031	protein transport across the cell outer membrane
I5M77_RS13095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5M77_RS13100	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5M77_RS13105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I5M77_RS13115	COG0456	acetyltransferase
I5M77_RS13120	COG1490	D-aminoacyl-tRNA deacylase activity
I5M77_RS13125	COG1295	ribonuclease BN
I5M77_RS13140	COG1217	gtp-binding protein TYPA
I5M77_RS13145	COG0174	glutamine synthetase
I5M77_RS13155	COG3852	Histidine kinase
I5M77_RS13160	COG2204	response regulator
I5M77_RS13170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I5M77_RS13200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I5M77_RS13205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5M77_RS13205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5M77_RS13225	COG0084	hydrolase, TatD family'
I5M77_RS13230	COG0805	protein transport
I5M77_RS13235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5M77_RS13240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5M77_RS13245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I5M77_RS13250	COG3165	ubiquinone biosynthetic process from chorismate
I5M77_RS13255	COG2226	methyltransferase
I5M77_RS13260	COG1322	Protein conserved in bacteria
I5M77_RS13275	COG0628	permease
I5M77_RS13325	COG2823	Periplasmic or secreted lipoprotein
I5M77_RS13335	COG2081	HI0933 family
I5M77_RS13345	COG1528	Iron-storage protein
I5M77_RS13350	COG0589	response to stress
I5M77_RS13365	COG0742	ribosomal rna small subunit methyltransferase
I5M77_RS13370	COG5001	Diguanylate cyclase
I5M77_RS13370	COG5002	protein histidine kinase activity
I5M77_RS13375	COG1522	sequence-specific DNA binding
I5M77_RS13380	COG0339	signal peptide processing
I5M77_RS13385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5M77_RS13390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M77_RS13395	COG0583	DNA-binding transcription factor activity
I5M77_RS13400	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I5M77_RS13405	COG0800	Aldolase
I5M77_RS13410	COG2610	gluconate transmembrane transporter activity
I5M77_RS13415	COG3265	gluconokinase activity
I5M77_RS13420	COG0129	dihydroxy-acid dehydratase activity
I5M77_RS13435	COG0583	DNA-binding transcription factor activity
I5M77_RS13440	COG1609	Transcriptional regulator
I5M77_RS13475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M77_RS13480	COG0601	transmembrane transport
I5M77_RS13485	COG0747	negative chemotaxis
I5M77_RS13490	COG4172	Belongs to the ABC transporter superfamily
I5M77_RS13540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS13545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M77_RS13550	COG2960	long-chain fatty acid transporting porin activity
I5M77_RS13555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I5M77_RS13560	COG0583	DNA-binding transcription factor activity
I5M77_RS13600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5M77_RS13605	COG1739	Uncharacterized protein family UPF0029
I5M77_RS13610	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M77_RS13610	COG1024	Enoyl-CoA hydratase
I5M77_RS13615	COG0183	Belongs to the thiolase family
I5M77_RS13620	COG0604	alcohol dehydrogenase
I5M77_RS13635	COG0425	Belongs to the sulfur carrier protein TusA family
I5M77_RS13645	COG2119	membrane
I5M77_RS13650	COG0752	glycyl-tRNA synthetase alpha subunit
I5M77_RS13655	COG0751	glycine-tRNA ligase activity
I5M77_RS13660	COG0366	Alpha amylase catalytic
I5M77_RS13665	COG3977	Valine--pyruvate aminotransferase
I5M77_RS13670	COG0071	Belongs to the small heat shock protein (HSP20) family
I5M77_RS13680	COG0187	DNA topoisomerase II activity
I5M77_RS13685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5M77_RS13690	COG0592	DNA-directed DNA polymerase activity
I5M77_RS13695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5M77_RS13710	COG1126	abc transporter atp-binding protein
I5M77_RS13720	COG0594	ribonuclease P activity
I5M77_RS13730	COG0706	membrane insertase activity
I5M77_RS13735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5M77_RS13740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5M77_RS13745	COG0445	tRNA wobble uridine modification
I5M77_RS13750	COG0357	Ribosomal RNA small subunit methyltransferase G
I5M77_RS13755	COG1192	Involved in chromosome partitioning
I5M77_RS13760	COG1475	DNA binding
I5M77_RS13765	COG3312	ion transport
I5M77_RS13770	COG0356	it plays a direct role in the translocation of protons across the membrane
I5M77_RS13785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5M77_RS13790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I5M77_RS13795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I5M77_RS13800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I5M77_RS13805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I5M77_RS13810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5M77_RS13815	COG0765	amino acid transport
I5M77_RS13820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M77_RS13825	COG2814	Major facilitator Superfamily
I5M77_RS13830	COG0583	DNA-binding transcription factor activity
I5M77_RS13840	COG0129	dihydroxy-acid dehydratase activity
I5M77_RS13845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5M77_RS13850	COG3978	acetolactate synthase activity
I5M77_RS13860	COG0606	chelatase, subunit chli
I5M77_RS13870	COG0204	Acyl-transferase
I5M77_RS13875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M77_RS13880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5M77_RS13890	COG3084	Protein conserved in bacteria
I5M77_RS13900	COG4326	sporulation control protein
I5M77_RS13905	COG1272	protein, Hemolysin III
I5M77_RS13915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5M77_RS13920	COG0569	domain protein
I5M77_RS13925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5M77_RS13925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5M77_RS13930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5M77_RS13935	COG0242	peptide deformylase activity
I5M77_RS13945	COG0758	DNA mediated transformation
I5M77_RS13950	COG2922	Belongs to the Smg family
I5M77_RS13955	COG0551	DNA topoisomerase type I activity
I5M77_RS13960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5M77_RS13965	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5M77_RS13970	COG0009	L-threonylcarbamoyladenylate synthase
I5M77_RS13975	COG0408	coproporphyrinogen oxidase activity
I5M77_RS13980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M77_RS13990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M77_RS14030	COG0582	viral genome integration into host DNA
I5M77_RS14085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5M77_RS14140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5M77_RS14200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I5M77_RS14205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I5M77_RS14210	COG0352	thiamine-phosphate diphosphorylase activity
I5M77_RS14215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M77_RS14220	COG2104	thiamine diphosphate biosynthetic process
I5M77_RS14225	COG2022	thiamine diphosphate biosynthetic process
I5M77_RS14235	COG0006	proline dipeptidase activity
I5M77_RS14265	COG3220	belongs to the UPF0276 family
I5M77_RS14275	COG0210	DNA helicase
I5M77_RS14290	COG1280	lysine exporter protein (LysE YggA)
I5M77_RS14300	COG2962	Rard protein
I5M77_RS14305	COG0514	ATP-dependent DNA helicase (RecQ)
I5M77_RS14315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5M77_RS14320	COG0248	Ppx GppA phosphatase
I5M77_RS14325	COG0513	Belongs to the DEAD box helicase family
I5M77_RS14330	COG3118	belongs to the thioredoxin family
I5M77_RS14345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M77_RS14350	COG0633	Ferredoxin
I5M77_RS14395	COG3071	HemY protein
I5M77_RS14400	COG2959	enzyme of heme biosynthesis
I5M77_RS14405	COG1587	Uroporphyrinogen-III synthase
I5M77_RS14410	COG0181	hydroxymethylbilane synthase activity
I5M77_RS14415	COG3072	Adenylate cyclase
I5M77_RS14420	COG1965	Belongs to the frataxin family
I5M77_RS14430	COG0019	diaminopimelate decarboxylase activity
I5M77_RS14435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I5M77_RS14445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5M77_RS14450	COG1011	Hydrolase
I5M77_RS14455	COG3287	FIST C domain
I5M77_RS14455	COG2199	diguanylate cyclase activity
I5M77_RS14455	COG2200	EAL domain
I5M77_RS14460	COG3148	PFAM DTW domain containing protein
I5M77_RS14475	COG0561	phosphatase activity
I5M77_RS14480	COG2267	carboxylic ester hydrolase activity
I5M77_RS14485	COG1280	lysine exporter protein (LysE YggA)
I5M77_RS14490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I5M77_RS14495	COG0640	Transcriptional regulator
I5M77_RS14500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5M77_RS14550	COG2095	MarC family integral membrane protein
I5M77_RS14560	COG0742	ribosomal rna small subunit methyltransferase
I5M77_RS14565	COG0552	protein localization to endoplasmic reticulum
I5M77_RS14570	COG2884	Cell division ATP-binding protein ftsE
I5M77_RS14575	COG2177	Part of the ABC transporter FtsEX involved in
I5M77_RS14585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M77_RS14590	COG0705	Rhomboid family
I5M77_RS14595	COG1580	Controls the rotational direction of flagella during chemotaxis
I5M77_RS14600	COG3161	chorismate lyase activity
I5M77_RS14605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I5M77_RS14610	COG2937	Belongs to the GPAT DAPAT family
I5M77_RS14615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5M77_RS14620	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I5M77_RS14625	COG0534	Mate efflux family protein
I5M77_RS14630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M77_RS14645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5M77_RS14650	COG4206	TonB-dependent receptor
I5M77_RS14660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5M77_RS14715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M77_RS14725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5M77_RS14760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5M77_RS14765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5M77_RS14770	COG0250	Participates in transcription elongation, termination and antitermination
I5M77_RS14775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I5M77_RS14780	COG0081	regulation of translation
I5M77_RS14785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I5M77_RS14790	COG0222	ribosome binding
I5M77_RS14795	COG0085	RNA polymerase activity
I5M77_RS14800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I5M77_RS14805	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I5M77_RS14810	COG2816	NAD+ diphosphatase activity
I5M77_RS14825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I5M77_RS14830	COG1573	uracil-dna glycosylase
I5M77_RS14835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M77_RS14845	COG1253	flavin adenine dinucleotide binding
I5M77_RS14860	COG0151	Belongs to the GarS family
I5M77_RS14865	COG0138	bifunctional purine biosynthesis protein purh
I5M77_RS14870	COG0789	Transcriptional regulator
I5M77_RS14875	COG3710	Transcriptional regulator
I5M77_RS14880	COG0531	amino acid
I5M77_RS14885	COG1982	Orn Lys Arg decarboxylase major
I5M77_RS14955	COG3706	GGDEF domain
I5M77_RS14960	COG0488	(ABC) transporter
I5M77_RS14965	COG2814	Major facilitator Superfamily
I5M77_RS14970	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I5M77_RS14975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M77_RS14980	COG2264	protein methyltransferase activity
I5M77_RS14985	COG0439	Biotin carboxylase
I5M77_RS14990	COG0511	ligase activity, forming carbon-carbon bonds
I5M77_RS14995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5M77_RS15000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5M77_RS15015	COG2814	Major facilitator Superfamily
I5M77_RS15020	COG2205	protein histidine kinase activity
I5M77_RS15020	COG2198	Histidine kinase
I5M77_RS15020	COG0784	Response regulator, receiver
I5M77_RS15040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5M77_RS15050	COG3263	regulation of cellular component size
I5M77_RS15060	COG4232	protein-disulfide reductase activity
I5M77_RS15065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M77_RS15070	COG1027	Aspartate ammonia-lyase
I5M77_RS15075	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5M77_RS15080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5M77_RS15090	COG2205	protein histidine kinase activity
I5M77_RS15095	COG0745	RESPONSE REGULATOR receiver
I5M77_RS15100	COG3678	ATP-independent chaperone mediated protein folding
I5M77_RS15110	COG0205	6-phosphofructokinase activity
I5M77_RS15115	COG0534	Mate efflux family protein
I5M77_RS15125	COG0459	protein refolding
I5M77_RS15140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5M77_RS15145	COG1509	lysine 2,3-aminomutase activity
I5M77_RS15150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I5M77_RS15160	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I5M77_RS15165	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I5M77_RS15170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M77_RS15175	COG1053	succinate dehydrogenase
I5M77_RS15180	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I5M77_RS15200	COG4942	peptidase
I5M77_RS15205	COG1045	serine acetyltransferase
I5M77_RS15210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I5M77_RS15215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I5M77_RS15220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M77_RS15225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I5M77_RS15270	COG0471	metal ion transport
I5M77_RS15275	COG0688	phosphatidylethanolamine metabolic process
I5M77_RS15280	COG1162	GTPase activity
I5M77_RS15285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I5M77_RS15355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5M77_RS15360	COG0802	atpase or kinase
I5M77_RS15365	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M77_RS15370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5M77_RS15375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I5M77_RS15385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5M77_RS15390	COG0330	HflC and HflK could
I5M77_RS15395	COG0330	HflC and HflK could
I5M77_RS15400	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I5M77_RS15405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5M77_RS15410	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I5M77_RS15415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M77_RS15415	COG1017	nitric oxide dioxygenase activity
I5M77_RS15420	COG1959	2 iron, 2 sulfur cluster binding
I5M77_RS15425	COG0557	exoribonuclease II activity
I5M77_RS15430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M77_RS15435	COG0546	phosphoglycolate phosphatase activity
I5M77_RS15440	COG0180	Tryptophanyl-tRNA synthetase
I5M77_RS15455	COG0512	Glutamine amidotransferase of anthranilate synthase
I5M77_RS15460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M77_RS15470	COG1012	belongs to the aldehyde dehydrogenase family
I5M77_RS15480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M77_RS15485	COG3954	Phosphoribulokinase
I5M77_RS15490	COG3089	Belongs to the UPF0270 family
I5M77_RS15495	COG0429	hydrolase of the alpha beta-hydrolase fold
I5M77_RS15505	COG0488	(ABC) transporter
I5M77_RS15510	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M77_RS15525	COG1047	Peptidyl-prolyl cis-trans
I5M77_RS15530	COG1446	asparaginase
I5M77_RS15535	COG2900	Belongs to the SlyX family
I5M77_RS15545	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M77_RS15550	COG2964	Protein conserved in bacteria
I5M77_RS15555	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I5M77_RS15560	COG2923	Belongs to the DsrF TusC family
I5M77_RS15565	COG2168	tRNA wobble position uridine thiolation
I5M77_RS15575	COG0049	tRNA binding
I5M77_RS15580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5M77_RS15585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5M77_RS15590	COG2906	2 iron, 2 sulfur cluster binding
I5M77_RS15600	COG0281	malic enzyme
I5M77_RS15610	COG0626	cystathionine gamma-synthase activity
I5M77_RS15615	COG0460	homoserine dehydrogenase
I5M77_RS15615	COG0527	aspartate kinase activity
I5M77_RS15620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5M77_RS15630	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I5M77_RS15635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5M77_RS15640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5M77_RS15645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5M77_RS15650	COG0137	argininosuccinate synthase activity
I5M77_RS15655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5M77_RS15655	COG0165	Argininosuccinate lyase
I5M77_RS15665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M77_RS15665	COG0678	peroxiredoxin activity
I5M77_RS15675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I5M77_RS15705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M77_RS15710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5M77_RS15720	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I5M77_RS15725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M77_RS15730	COG0360	Binds together with S18 to 16S ribosomal RNA
I5M77_RS15735	COG2965	DNA replication, synthesis of RNA primer
I5M77_RS15745	COG0359	binds to the 23S rRNA
I5M77_RS15760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5M77_RS15770	COG0432	Pfam Uncharacterised protein family UPF0047
I5M77_RS15775	COG0166	Belongs to the GPI family
I5M77_RS15785	COG0735	belongs to the Fur family
I5M77_RS15790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M77_RS15810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5M77_RS15815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M77_RS15820	COG0175	sulfate reduction
I5M77_RS15875	COG3335	DDE superfamily endonuclease
I5M77_RS15890	COG0646	methionine synthase
I5M77_RS15890	COG1410	methionine synthase
I5M77_RS15895	COG0527	aspartate kinase activity
I5M77_RS15900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5M77_RS15910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5M77_RS15925	COG0629	single-stranded DNA binding
I5M77_RS15930	COG2200	EAL domain
I5M77_RS15930	COG2199	diguanylate cyclase activity
I5M77_RS15955	COG3409	Peptidoglycan-binding domain 1 protein
I5M77_RS15955	COG3267	Type II secretory pathway component ExeA
I5M77_RS15965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5M77_RS15970	COG1459	type II secretion system
I5M77_RS15980	COG2165	general secretion pathway protein
I5M77_RS16015	COG1077	Cell shape determining protein MreB Mrl
I5M77_RS16020	COG1792	Involved in formation and maintenance of cell shape
I5M77_RS16025	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5M77_RS16030	COG0424	maF-like protein
I5M77_RS16040	COG3164	Protein of unknown function
I5M77_RS16045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M77_RS16050	COG0312	modulator of DNA gyrase
I5M77_RS16055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I5M77_RS16060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5M77_RS16070	COG0564	pseudouridine synthase activity
I5M77_RS16075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5M77_RS16080	COG3028	Belongs to the UPF0307 family
I5M77_RS16085	COG0312	modulator of DNA gyrase
I5M77_RS16090	COG2239	Acts as a magnesium transporter
I5M77_RS16095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M77_RS16100	COG1660	Displays ATPase and GTPase activities
I5M77_RS16105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M77_RS16110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M77_RS16120	COG1137	ATPase activity
I5M77_RS16125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5M77_RS16135	COG0517	IMP dehydrogenase activity
I5M77_RS16135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I5M77_RS16145	COG1127	ABC transporter
I5M77_RS16150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5M77_RS16155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M77_RS16160	COG2854	intermembrane phospholipid transfer
I5M77_RS16170	COG5007	Belongs to the BolA IbaG family
I5M77_RS16175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5M77_RS16180	COG0204	Acyl-transferase
I5M77_RS16185	COG0251	oxidation-reduction process
I5M77_RS16190	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I5M77_RS16195	COG0540	Belongs to the ATCase OTCase family
I5M77_RS16205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5M77_RS16210	COG2235	arginine
I5M77_RS16295	COG3501	Rhs element vgr protein
I5M77_RS16350	COG0525	valine-tRNA ligase activity
I5M77_RS16355	COG2927	DNA polymerase III (CHI subunit)
I5M77_RS16360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5M77_RS16365	COG0795	lipopolysaccharide-transporting ATPase activity
I5M77_RS16370	COG0795	lipopolysaccharide-transporting ATPase activity
I5M77_RS16385	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS16515	COG0582	viral genome integration into host DNA
I5M77_RS16555	COG0726	polysaccharide deacetylase
I5M77_RS16560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M77_RS16565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M77_RS16570	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M77_RS16575	COG1486	melibiose metabolic process
I5M77_RS16580	COG3394	polysaccharide catabolic process
I5M77_RS16590	COG3437	response regulator, receiver
I5M77_RS16635	COG1012	belongs to the aldehyde dehydrogenase family
I5M77_RS16665	COG0840	transmembrane signaling receptor activity
I5M77_RS16705	COG0741	lytic transglycosylase activity
I5M77_RS16710	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I5M77_RS16720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5M77_RS16730	COG2066	Belongs to the glutaminase family
I5M77_RS16735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5M77_RS16740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I5M77_RS16750	COG1872	DUF167
I5M77_RS16755	COG0762	integral membrane protein
I5M77_RS16760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5M77_RS16765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5M77_RS16780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I5M77_RS16785	COG1678	Uncharacterized ACR, COG1678
I5M77_RS16790	COG0189	ligase activity
I5M77_RS16795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5M77_RS16800	COG2356	endonuclease I
I5M77_RS16805	COG3091	SprT-like family
I5M77_RS16815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5M77_RS16820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M77_RS16825	COG0583	DNA-binding transcription factor activity
I5M77_RS16830	COG4771	TonB-dependent receptor
I5M77_RS16835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5M77_RS16840	COG0126	phosphoglycerate kinase activity
I5M77_RS16845	COG0191	fructose-bisphosphate aldolase activity
I5M77_RS16850	COG0668	transmembrane transport
I5M77_RS16855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M77_RS16865	COG0583	DNA-binding transcription factor activity
I5M77_RS16875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M77_RS16880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I5M77_RS16885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5M77_RS16895	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I5M77_RS16900	COG3079	Belongs to the UPF0149 family
I5M77_RS16905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M77_RS16910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M77_RS16925	COG0354	folic acid binding
I5M77_RS16930	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5M77_RS16940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I5M77_RS16945	COG1595	DNA-templated transcription, initiation
I5M77_RS16950	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I5M77_RS16960	COG3086	response to oxidative stress
I5M77_RS16965	COG0481	GTPase activity
I5M77_RS16975	COG0571	ribonuclease III activity
I5M77_RS16980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5M77_RS16985	COG1381	Involved in DNA repair and RecF pathway recombination
I5M77_RS16990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5M77_RS16995	COG0736	holo-[acyl-carrier-protein] synthase activity
I5M77_RS17005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5M77_RS17010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M77_RS17015	COG3956	TIGRFAM MazG family protein
I5M77_RS17020	COG0504	CTP synthase activity
I5M77_RS17025	COG0148	phosphopyruvate hydratase activity
I5M77_RS17030	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I5M77_RS17035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I5M77_RS17040	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I5M77_RS17045	COG0585	pseudouridine synthase activity
I5M77_RS17050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I5M77_RS17055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I5M77_RS17065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M77_RS17070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5M77_RS17075	COG1546	Belongs to the CinA family
I5M77_RS17080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I5M77_RS17085	COG2137	regulation of response to DNA damage stimulus
I5M77_RS17090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5M77_RS17095	COG0527	aspartate kinase activity
I5M77_RS17150	COG3630	sodium ion export across plasma membrane
I5M77_RS17155	COG5016	pyruvate
I5M77_RS17155	COG0511	ligase activity, forming carbon-carbon bonds
I5M77_RS17160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I5M77_RS17170	COG1238	metal cluster binding
I5M77_RS17175	COG0612	Peptidase, M16
I5M77_RS17180	COG2918	glutathione biosynthetic process
I5M77_RS17190	COG1854	S-ribosylhomocysteine lyase activity
I5M77_RS17195	COG4536	flavin adenine dinucleotide binding
I5M77_RS17200	COG4137	Cytochrome C assembly protein
I5M77_RS17205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5M77_RS17210	COG0228	four-way junction DNA binding
I5M77_RS17215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5M77_RS17220	COG0336	Belongs to the RNA methyltransferase TrmD family
I5M77_RS17225	COG0335	large ribosomal subunit rRNA binding
I5M77_RS17230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I5M77_RS17235	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I5M77_RS17240	COG0237	dephospho-CoA kinase activity
I5M77_RS17250	COG1459	type II secretion system
I5M77_RS17255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5M77_RS17265	COG0157	Belongs to the NadC ModD family
I5M77_RS17275	COG2186	Transcriptional regulator
I5M77_RS17280	COG4771	TonB-dependent receptor
I5M77_RS17280	COG1629	transport
I5M77_RS17285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5M77_RS17290	COG5002	protein histidine kinase activity
I5M77_RS17290	COG5001	Diguanylate cyclase
I5M77_RS17290	COG3447	MASE1 domain protein
I5M77_RS17295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5M77_RS17300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5M77_RS17305	COG1984	allophanate hydrolase subunit 2
I5M77_RS17315	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5M77_RS17320	COG4181	ATPase activity
I5M77_RS17330	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5M77_RS17335	COG5001	Diguanylate cyclase
I5M77_RS17335	COG3300	MHYT domain
I5M77_RS17345	COG0484	heat shock protein binding
I5M77_RS17370	COG4533	DNA binding
I5M77_RS17380	COG2050	protein possibly involved in aromatic compounds catabolism
I5M77_RS17395	COG2067	long-chain fatty acid transport protein
I5M77_RS17400	COG2267	carboxylic ester hydrolase activity
I5M77_RS17415	COG0861	Integral membrane protein TerC family
I5M77_RS17420	COG0737	Belongs to the 5'-nucleotidase family
I5M77_RS17425	COG3593	DNA synthesis involved in DNA repair
I5M77_RS17435	COG0583	DNA-binding transcription factor activity
I5M77_RS17440	COG2116	formate transmembrane transporter activity
I5M77_RS17445	COG2353	YceI-like domain
I5M77_RS17450	COG3038	cytochrome b561
I5M77_RS17465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M77_RS17470	COG0513	Belongs to the DEAD box helicase family
I5M77_RS17475	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I5M77_RS17480	COG0840	transmembrane signaling receptor activity
I5M77_RS17485	COG0546	phosphoglycolate phosphatase activity
I5M77_RS17490	COG3437	response regulator, receiver
I5M77_RS17490	COG0784	Response regulator, receiver
I5M77_RS17505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M77_RS17510	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I5M77_RS17515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I5M77_RS17525	COG2207	Transcriptional regulator
I5M77_RS17530	COG1979	alcohol dehydrogenase
I5M77_RS17555	COG2271	Major facilitator Superfamily
I5M77_RS17560	COG0469	pyruvate kinase activity
I5M77_RS17565	COG1126	abc transporter atp-binding protein
I5M77_RS17570	COG0765	amino acid transport
I5M77_RS17575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M77_RS17580	COG0765	amino acid transport
I5M77_RS17585	COG2203	Gaf domain
I5M77_RS17585	COG2200	EAL domain
I5M77_RS17585	COG2199	diguanylate cyclase activity
I5M77_RS17600	COG1609	Transcriptional regulator
I5M77_RS17605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M77_RS17605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M77_RS17610	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M77_RS17615	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5M77_RS17615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M77_RS17615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M77_RS17655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5M77_RS17660	COG0509	glycine decarboxylation via glycine cleavage system
I5M77_RS17665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5M77_RS17665	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5M77_RS17715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I5M77_RS17720	COG0583	DNA-binding transcription factor activity
I5M77_RS17725	COG2176	DNA-directed DNA polymerase activity
I5M77_RS17770	COG0242	peptide deformylase activity
I5M77_RS17800	COG2239	Acts as a magnesium transporter
I5M77_RS17820	COG0346	lactoylglutathione lyase activity
I5M77_RS17825	COG1902	pentaerythritol trinitrate reductase activity
I5M77_RS17845	COG5642	Protein of unknown function (DUF2384)
I5M77_RS17850	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I5M77_RS17865	COG4565	transcriptional regulatory protein
I5M77_RS17870	COG3290	protein histidine kinase activity
I5M77_RS17875	COG0471	metal ion transport
I5M77_RS17920	COG0671	phosphoesterase, PA-phosphatase related
I5M77_RS17930	COG2962	Rard protein
I5M77_RS17945	COG0784	Response regulator, receiver
I5M77_RS17945	COG0835	chemotaxis
I5M77_RS17965	COG2197	response regulator
I5M77_RS17975	COG3706	GGDEF domain
I5M77_RS17980	COG2197	response regulator
I5M77_RS17985	COG5001	Diguanylate cyclase
I5M77_RS17985	COG3300	MHYT domain
I5M77_RS18000	COG0583	DNA-binding transcription factor activity
I5M77_RS18005	COG0583	DNA-binding transcription factor activity
I5M77_RS18065	COG4964	Belongs to the GSP D family
I5M77_RS18090	COG2207	Transcriptional regulator
I5M77_RS18110	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5M77_RS18130	COG1214	PFAM Peptidase M22, glycoprotease
I5M77_RS18130	COG0456	acetyltransferase
I5M77_RS18140	COG3069	C4-dicarboxylate transmembrane transporter activity
I5M77_RS18145	COG1704	LemA family
I5M77_RS18150	COG0501	Belongs to the peptidase M48B family
I5M77_RS18175	COG0641	radical SAM
I5M77_RS18190	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M77_RS18195	COG1597	lipid kinase activity
I5M77_RS18200	COG0583	DNA-binding transcription factor activity
I5M77_RS18205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M77_RS18235	COG0714	Associated with various cellular activities
I5M77_RS18240	COG0641	radical SAM
I5M77_RS18245	COG3119	arylsulfatase activity
I5M77_RS18260	COG3119	arylsulfatase activity
I5M77_RS18265	COG3119	arylsulfatase activity
I5M77_RS18270	COG0745	RESPONSE REGULATOR receiver
I5M77_RS18285	COG2198	Histidine kinase
I5M77_RS18285	COG2205	protein histidine kinase activity
I5M77_RS18285	COG0784	Response regulator, receiver
I5M77_RS18290	COG1879	ABC-type sugar transport system periplasmic component
I5M77_RS18295	COG1803	Methylglyoxal synthase
I5M77_RS18300	COG0210	DNA helicase
I5M77_RS18305	COG1289	transmembrane transporter activity
I5M77_RS18335	COG4771	TonB-dependent receptor
I5M77_RS18335	COG1629	transport
I5M77_RS18345	COG0789	Transcriptional regulator
I5M77_RS18350	COG4604	ABC transporter, ATP-binding protein
I5M77_RS18355	COG4605	iron ion homeostasis
I5M77_RS18360	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M77_RS18365	COG4607	ABC-type enterochelin transport system periplasmic component
I5M77_RS18385	COG2847	Copper chaperone PCu(A)C
I5M77_RS18390	COG0443	Heat shock 70 kDa protein
I5M77_RS18425	COG0625	glutathione transferase activity
I5M77_RS18440	COG4160	amino acid transport
I5M77_RS18445	COG4215	(ABC) transporter
I5M77_RS18450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M77_RS18455	COG1126	abc transporter atp-binding protein
I5M77_RS18485	COG1902	pentaerythritol trinitrate reductase activity
I5M77_RS18495	COG0109	protoheme IX farnesyltransferase activity
I5M77_RS18500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5M77_RS18505	COG1845	cytochrome c oxidase, subunit III
I5M77_RS18510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5M77_RS18515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5M77_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS18530	COG1024	Enoyl-CoA hydratase
I5M77_RS18535	COG1024	Enoyl-CoA hydratase
I5M77_RS18550	COG0183	Belongs to the thiolase family
I5M77_RS18560	COG1960	acyl-CoA dehydrogenase activity
I5M77_RS18565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5M77_RS18570	COG1024	Enoyl-CoA hydratase
I5M77_RS18580	COG5413	integral membrane protein
I5M77_RS18595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I5M77_RS18600	COG5001	Diguanylate cyclase
I5M77_RS18605	COG0513	Belongs to the DEAD box helicase family
I5M77_RS18610	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I5M77_RS18625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5M77_RS18645	COG0641	radical SAM
I5M77_RS18665	COG0840	transmembrane signaling receptor activity
I5M77_RS18670	COG1119	ATPase activity
I5M77_RS18675	COG2200	EAL domain
I5M77_RS18695	COG0513	Belongs to the DEAD box helicase family
I5M77_RS18700	COG0523	cobalamin synthesis protein
I5M77_RS18710	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I5M77_RS18720	COG0133	tryptophan synthase activity
I5M77_RS18725	COG4628	conserved protein (DUF2132)
I5M77_RS18730	COG0513	Belongs to the DEAD box helicase family
I5M77_RS18735	COG3530	Putative quorum-sensing-regulated virulence factor
I5M77_RS18755	COG2154	pterin-4-alpha-carbinolamine dehydratase
I5M77_RS18760	COG3186	Phenylalanine-4-hydroxylase
I5M77_RS18765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5M77_RS18770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5M77_RS18810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5M77_RS18815	COG1454	alcohol dehydrogenase
I5M77_RS18820	COG2133	pyrroloquinoline quinone binding
I5M77_RS18830	COG0783	Belongs to the Dps family
I5M77_RS18835	COG0840	transmembrane signaling receptor activity
I5M77_RS18845	COG1136	(ABC) transporter
I5M77_RS18845	COG0577	efflux transmembrane transporter activity
I5M77_RS18865	COG2199	diguanylate cyclase activity
I5M77_RS18875	COG3036	rescue of stalled ribosome
I5M77_RS18880	COG1278	Cold shock
I5M77_RS18910	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M77_RS18915	COG0109	protoheme IX farnesyltransferase activity
I5M77_RS18920	COG1612	heme a metabolic process
I5M77_RS18945	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I5M77_RS18955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5M77_RS18960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5M77_RS18970	COG1280	lysine exporter protein (LysE YggA)
I5M77_RS18975	COG2207	Transcriptional regulator
I5M77_RS19000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M77_RS19005	COG0697	spore germination
I5M77_RS19020	COG2814	Major facilitator Superfamily
I5M77_RS19025	COG0583	DNA-binding transcription factor activity
I5M77_RS19030	COG5001	Diguanylate cyclase
I5M77_RS19035	COG0739	heme binding
I5M77_RS19055	COG3314	Sporulation integral membrane protein YlbJ
I5M77_RS19070	COG0814	amino acid
I5M77_RS19090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I5M77_RS19095	COG1072	(Pantothenic acid kinase))
I5M77_RS19105	COG1063	alcohol dehydrogenase
I5M77_RS19110	COG2213	PTS system mannitol-specific
I5M77_RS19115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M77_RS19130	COG0798	PFAM Bile acid sodium symporter
I5M77_RS19140	COG1881	PFAM PEBP family protein
I5M77_RS19150	COG2706	6-phosphogluconolactonase activity
I5M77_RS19155	COG0840	transmembrane signaling receptor activity
I5M77_RS19165	COG1131	(ABC) transporter
I5M77_RS19170	COG0842	Transport permease protein
I5M77_RS19185	COG3383	formate dehydrogenase (NAD+) activity
I5M77_RS19205	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M77_RS19235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M77_RS19245	COG2067	long-chain fatty acid transport protein
I5M77_RS19255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS19265	COG1505	serine-type exopeptidase activity
I5M77_RS19270	COG0488	(ABC) transporter
I5M77_RS19275	COG0589	response to stress
I5M77_RS19280	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M77_RS19300	COG0366	Alpha amylase catalytic
I5M77_RS19310	COG4934	collagen metabolic process
I5M77_RS19325	COG0583	DNA-binding transcription factor activity
I5M77_RS19330	COG0783	Belongs to the Dps family
I5M77_RS19335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I5M77_RS19360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I5M77_RS19360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M77_RS19370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M77_RS19375	COG0784	Response regulator, receiver
I5M77_RS19375	COG0835	chemotaxis
I5M77_RS19385	COG0748	coenzyme F420 binding
I5M77_RS19390	COG3721	Heme iron utilization protein
I5M77_RS19400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I5M77_RS19405	COG0811	peptide transport
I5M77_RS19410	COG0848	biopolymer transport protein
I5M77_RS19420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M77_RS19425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I5M77_RS19465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5M77_RS19470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I5M77_RS19475	COG0633	Ferredoxin
I5M77_RS19475	COG3217	Mosc domain protein beta barrel domain protein
I5M77_RS19475	COG0633	Ferredoxin
I5M77_RS19475	COG3217	Mosc domain protein beta barrel domain protein
I5M77_RS19480	COG0401	homolog of Blt101
I5M77_RS19485	COG0418	dihydroorotase activity
I5M77_RS19490	COG2354	Protein conserved in bacteria
I5M77_RS19520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M77_RS19520	COG2207	Transcriptional regulator
I5M77_RS19525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M77_RS19565	COG0513	Belongs to the DEAD box helicase family
I5M77_RS19575	COG0583	DNA-binding transcription factor activity
I5M77_RS19590	COG1902	pentaerythritol trinitrate reductase activity
I5M77_RS19595	COG1063	alcohol dehydrogenase
I5M77_RS19605	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS19615	COG3122	Protein conserved in bacteria
I5M77_RS19630	COG0583	DNA-binding transcription factor activity
I5M77_RS19635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5M77_RS19640	COG0252	asparaginase activity
I5M77_RS19645	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I5M77_RS19650	COG0574	Belongs to the PEP-utilizing enzyme family
I5M77_RS19650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5M77_RS19665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5M77_RS19685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS19705	COG3706	GGDEF domain
I5M77_RS19725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M77_RS19755	COG3842	ATPase activity
I5M77_RS19790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M77_RS19825	COG0583	DNA-binding transcription factor activity
I5M77_RS19835	COG4948	Mandelate Racemase Muconate Lactonizing
I5M77_RS19865	COG1342	Belongs to the UPF0251 family
I5M77_RS19870	COG3015	lipoprotein NlpE involved in copper resistance
I5M77_RS19875	COG3713	MltA-interacting MipA family protein
I5M77_RS19890	COG0583	DNA-binding transcription factor activity
I5M77_RS19915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5M77_RS19925	COG1335	isochorismatase
I5M77_RS19935	COG0753	catalase activity
I5M77_RS19945	COG1349	DNA-binding transcription factor activity
I5M77_RS19970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M77_RS19975	COG3537	Alpha-1,2-mannosidase
I5M77_RS19980	COG3537	Alpha-1,2-mannosidase
I5M77_RS19990	COG3537	Alpha-1,2-mannosidase
I5M77_RS19995	COG2070	2-Nitropropane dioxygenase
I5M77_RS20000	COG0737	Belongs to the 5'-nucleotidase family
I5M77_RS20010	COG1309	transcriptional regulator
I5M77_RS20030	COG1280	lysine exporter protein (LysE YggA)
I5M77_RS20045	COG0459	protein refolding
I5M77_RS20050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I5M77_RS20055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M77_RS20080	COG1304	FMN binding
I5M77_RS20100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS20105	COG1256	bacterial-type flagellum assembly
I5M77_RS20105	COG4786	Flagellar basal body rod
I5M77_RS20115	COG1706	bacterial-type flagellum-dependent cell motility
I5M77_RS20120	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I5M77_RS20125	COG4786	Flagellar basal body rod
I5M77_RS20130	COG4787	bacterial-type flagellum-dependent cell motility
I5M77_RS20135	COG1749	Flagellar hook protein flgE
I5M77_RS20140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I5M77_RS20145	COG1558	bacterial-type flagellum-dependent cell motility
I5M77_RS20150	COG1815	bacterial-type flagellum-dependent cell motility
I5M77_RS20170	COG0741	lytic transglycosylase activity
I5M77_RS20175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I5M77_RS20195	COG1760	l-serine dehydratase
I5M77_RS20220	COG0583	DNA-binding transcription factor activity
I5M77_RS20230	COG2866	Carboxypeptidase
I5M77_RS20235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M77_RS20240	COG2990	Protein conserved in bacteria
I5M77_RS20455	COG3012	SEC-C Motif Domain Protein
I5M77_RS20480	COG3081	Nucleoid-associated protein
I5M77_RS20505	COG2842	Transposition protein
I5M77_RS20535	COG1840	ABC-type Fe3 transport system, periplasmic component
I5M77_RS20545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M77_RS20550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M77_RS20555	COG1609	Transcriptional regulator
I5M77_RS20585	COG3240	lipase activity
I5M77_RS20595	COG1136	(ABC) transporter
I5M77_RS20595	COG0577	efflux transmembrane transporter activity
I5M77_RS20600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS20605	COG2067	long-chain fatty acid transport protein
I5M77_RS20615	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I5M77_RS20630	COG1011	Hydrolase
I5M77_RS20670	COG0110	maltose O-acetyltransferase activity
I5M77_RS20675	COG1765	OsmC-like protein
I5M77_RS20680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5M77_RS20680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5M77_RS20695	COG3046	protein related to deoxyribodipyrimidine photolyase
I5M77_RS20700	COG0415	Belongs to the DNA photolyase family
I5M77_RS20705	COG3706	GGDEF domain
I5M77_RS20720	COG0840	transmembrane signaling receptor activity
I5M77_RS20725	COG3706	GGDEF domain
I5M77_RS20740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M77_RS20755	COG3033	Beta-eliminating lyase
I5M77_RS20765	COG0579	oxidoreductase
I5M77_RS20785	COG2199	diguanylate cyclase activity
I5M77_RS20825	COG0583	DNA-binding transcription factor activity
I5M77_RS20830	COG0189	ligase activity
I5M77_RS20835	COG0189	ligase activity
I5M77_RS20835	COG4067	protein conserved in archaea
I5M77_RS20845	COG1166	arginine decarboxylase activity
I5M77_RS20850	COG0010	Belongs to the arginase family
I5M77_RS20855	COG2814	Major facilitator Superfamily
I5M77_RS20860	COG1770	oligopeptidase
I5M77_RS20875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M77_RS20880	COG1121	(ABC) transporter
I5M77_RS20885	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5M77_RS20925	COG0848	biopolymer transport protein
I5M77_RS20930	COG0811	peptide transport
I5M77_RS20935	COG0811	peptide transport
I5M77_RS20955	COG0745	RESPONSE REGULATOR receiver
I5M77_RS20960	COG0039	L-malate dehydrogenase activity
I5M77_RS20965	COG0584	glycerophosphoryl diester phosphodiesterase
I5M77_RS20975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5M77_RS21030	COG1901	pseudouridine methyltransferase
I5M77_RS21035	COG0312	modulator of DNA gyrase
I5M77_RS21040	COG0312	modulator of DNA gyrase
I5M77_RS21045	COG0351	phosphomethylpyrimidine kinase
I5M77_RS21050	COG1116	anion transmembrane transporter activity
I5M77_RS21055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M77_RS21060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M77_RS21065	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5M77_RS21070	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I5M77_RS21075	COG0352	thiamine-phosphate diphosphorylase activity
I5M77_RS21085	COG0243	molybdopterin cofactor binding
I5M77_RS21090	COG3005	denitrification pathway
I5M77_RS21100	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS21115	COG0456	acetyltransferase
I5M77_RS21115	COG0454	-acetyltransferase
I5M77_RS21135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M77_RS21140	COG1929	Belongs to the glycerate kinase type-1 family
I5M77_RS21145	COG2610	gluconate transmembrane transporter activity
I5M77_RS21150	COG3835	regulator
I5M77_RS21175	COG0546	phosphoglycolate phosphatase activity
I5M77_RS21190	COG0583	DNA-binding transcription factor activity
I5M77_RS21200	COG0583	DNA-binding transcription factor activity
I5M77_RS21210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I5M77_RS21215	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I5M77_RS21215	COG3408	Glycogen debranching enzyme
I5M77_RS21245	COG3047	cAMP biosynthetic process
I5M77_RS21250	COG1357	PFAM Pentapeptide repeats (8 copies)
I5M77_RS21280	COG2375	cellular response to nickel ion
I5M77_RS21285	COG0823	Involved in the tonB-independent uptake of proteins
I5M77_RS21290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5M77_RS21310	COG0800	Aldolase
I5M77_RS21315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M77_RS21330	COG1917	Cupin 2, conserved barrel domain protein
I5M77_RS21340	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS21345	COG1414	Transcriptional regulator
I5M77_RS21360	COG0583	DNA-binding transcription factor activity
I5M77_RS21365	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I5M77_RS21370	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I5M77_RS21385	COG2199	diguanylate cyclase activity
I5M77_RS21395	COG0561	phosphatase activity
I5M77_RS21400	COG0583	DNA-binding transcription factor activity
I5M77_RS21415	COG0564	pseudouridine synthase activity
I5M77_RS21420	COG0534	Mate efflux family protein
I5M77_RS21425	COG5001	Diguanylate cyclase
I5M77_RS21435	COG3123	guanosine phosphorylase activity
I5M77_RS21475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5M77_RS21485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M77_RS21490	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5M77_RS21500	COG2259	Doxx family
I5M77_RS21505	COG1741	Belongs to the pirin family
I5M77_RS21525	COG0363	glucosamine-6-phosphate deaminase activity
I5M77_RS21535	COG0786	glutamate:sodium symporter activity
I5M77_RS21540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M77_RS21545	COG1131	(ABC) transporter
I5M77_RS21555	COG0786	glutamate:sodium symporter activity
I5M77_RS21580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5M77_RS21590	COG3279	Response regulator of the LytR AlgR family
I5M77_RS21595	COG3275	phosphorelay sensor kinase activity
I5M77_RS21625	COG0772	Belongs to the SEDS family
I5M77_RS21630	COG0217	transcriptional regulatory protein
I5M77_RS21650	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I5M77_RS21650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5M77_RS21660	COG0444	Belongs to the ABC transporter superfamily
I5M77_RS21665	COG4608	Belongs to the ABC transporter superfamily
I5M77_RS21690	COG1444	tRNA N-acetyltransferase activity
I5M77_RS21710	COG3340	Belongs to the peptidase S51 family
I5M77_RS21715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M77_RS21720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M77_RS21720	COG1263	PTS System
I5M77_RS21725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I5M77_RS21740	COG4166	transmembrane transport
I5M77_RS21785	COG0259	pyridoxamine-phosphate oxidase activity
I5M77_RS21810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5M77_RS21855	COG1132	(ABC) transporter
I5M77_RS21865	COG2207	Transcriptional regulator
I5M77_RS21885	COG0800	Aldolase
I5M77_RS21890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M77_RS21900	COG0246	Mannitol dehydrogenase
I5M77_RS21910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I5M77_RS21920	COG2186	Transcriptional regulator
I5M77_RS21930	COG0513	Belongs to the DEAD box helicase family
I5M77_RS21935	COG2258	MOSC domain
I5M77_RS21950	COG1486	melibiose metabolic process
I5M77_RS21955	COG0583	DNA-binding transcription factor activity
I5M77_RS21970	COG1595	DNA-templated transcription, initiation
I5M77_RS21995	COG3634	alkyl hydroperoxide reductase activity
I5M77_RS22005	COG1846	Transcriptional regulator
I5M77_RS22010	COG1764	response to oxidative stress
I5M77_RS22035	COG2160	L-arabinose isomerase activity
I5M77_RS22045	COG1069	ribulokinase activity
I5M77_RS22050	COG1879	ABC-type sugar transport system periplasmic component
I5M77_RS22055	COG1129	ABC transporter
I5M77_RS22060	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M77_RS22065	COG0826	peptidase U32
I5M77_RS22090	COG1653	transport
I5M77_RS22095	COG0019	diaminopimelate decarboxylase activity
I5M77_RS22100	COG4264	IucA IucC family
I5M77_RS22105	COG2814	Major facilitator Superfamily
I5M77_RS22125	COG4772	TonB-dependent receptor
I5M77_RS22130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5M77_RS22135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M77_RS22140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M77_RS22145	COG1120	ATPase activity
I5M77_RS22150	COG0840	transmembrane signaling receptor activity
I5M77_RS22155	COG0612	Peptidase, M16
I5M77_RS22165	COG0739	heme binding
I5M77_RS22190	COG4580	involved in the transport of maltose and maltodextrins
I5M77_RS22210	COG2356	endonuclease I
I5M77_RS22230	COG1982	Orn Lys Arg decarboxylase major
I5M77_RS22235	COG0531	amino acid
I5M77_RS22245	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5M77_RS22255	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I5M77_RS22260	COG1162	GTPase activity
I5M77_RS22265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M77_RS22265	COG1263	PTS System
I5M77_RS22275	COG1999	signal sequence binding
I5M77_RS22290	COG2909	trisaccharide binding
I5M77_RS22295	COG0058	SHG alpha-glucan phosphorylase activity
I5M77_RS22300	COG1640	4-alpha-glucanotransferase
I5M77_RS22305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5M77_RS22310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M77_RS22315	COG0366	Alpha amylase catalytic
I5M77_RS22325	COG3366	ferrous iron transmembrane transporter activity
I5M77_RS22330	COG0700	Nucleoside recognition
I5M77_RS22335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5M77_RS22340	COG3339	Conserved Protein
I5M77_RS22345	COG1301	dicarboxylic acid transport
I5M77_RS22355	COG0583	DNA-binding transcription factor activity
I5M77_RS22370	COG0489	protein tyrosine kinase activity
I5M77_RS22370	COG3206	protein involved in exopolysaccharide biosynthesis
I5M77_RS22390	COG2095	MarC family integral membrane protein
I5M77_RS22395	COG4667	esterase of the alpha-beta hydrolase superfamily
I5M77_RS22400	COG3397	chitin binding
I5M77_RS22405	COG1054	Belongs to the UPF0176 family
I5M77_RS22420	COG1686	Belongs to the peptidase S11 family
I5M77_RS22445	COG0583	DNA-binding transcription factor activity
I5M77_RS22450	COG4628	conserved protein (DUF2132)
I5M77_RS22460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M77_RS22470	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I5M77_RS22475	COG0628	permease
I5M77_RS22515	COG2814	Major facilitator Superfamily
I5M77_RS22525	COG0454	-acetyltransferase
I5M77_RS22535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M77_RS22540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M77_RS22545	COG1882	Formate acetyltransferase
I5M77_RS22575	COG1360	Flagellar Motor Protein
I5M77_RS22580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I5M77_RS22585	COG1191	sigma factor activity
I5M77_RS22590	COG1580	Controls the rotational direction of flagella during chemotaxis
I5M77_RS22605	COG1516	flagellar protein fliS
I5M77_RS22610	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5M77_RS22615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5M77_RS22630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5M77_RS22640	COG1987	bacterial-type flagellum assembly
I5M77_RS22720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I5M77_RS22740	COG0346	lactoylglutathione lyase activity
I5M77_RS22770	COG0745	RESPONSE REGULATOR receiver
I5M77_RS22790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M77_RS22800	COG0156	8-amino-7-oxononanoate synthase activity
I5M77_RS22805	COG1063	alcohol dehydrogenase
I5M77_RS22840	COG0668	transmembrane transport
I5M77_RS22850	COG1304	FMN binding
I5M77_RS22855	COG1620	l-lactate permease
I5M77_RS22860	COG0583	DNA-binding transcription factor activity
I5M77_RS22865	COG1505	serine-type exopeptidase activity
I5M77_RS22870	COG4172	Belongs to the ABC transporter superfamily
I5M77_RS22880	COG1067	ATP-dependent peptidase activity
I5M77_RS22905	COG1247	-acetyltransferase
I5M77_RS22910	COG0437	4 iron, 4 sulfur cluster binding
I5M77_RS22915	COG0348	domain, Protein
I5M77_RS22930	COG1122	ATPase activity
I5M77_RS22935	COG4720	Psort location CytoplasmicMembrane, score
I5M77_RS22940	COG1566	PFAM secretion protein HlyD family protein
I5M77_RS22950	COG3706	GGDEF domain
I5M77_RS22965	COG0813	purine-nucleoside phosphorylase activity
I5M77_RS22970	COG3272	Protein of unknown function (DUF1722)
I5M77_RS22975	COG0789	Transcriptional regulator
I5M77_RS22980	COG0415	Belongs to the DNA photolyase family
I5M77_RS22985	COG1376	ErfK ybiS ycfS ynhG family protein
I5M77_RS22985	COG1388	LysM domain
I5M77_RS22995	COG0513	Belongs to the DEAD box helicase family
I5M77_RS23000	COG1770	oligopeptidase
I5M77_RS23005	COG4771	TonB-dependent receptor
I5M77_RS23035	COG0573	inorganic phosphate transmembrane transporter activity
I5M77_RS23040	COG0581	inorganic phosphate transmembrane transporter activity
I5M77_RS23045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5M77_RS23065	COG2304	oxidoreductase activity
I5M77_RS23085	COG0714	Associated with various cellular activities
I5M77_RS23090	COG0840	transmembrane signaling receptor activity
I5M77_RS23100	COG2197	response regulator
I5M77_RS23120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M77_RS23150	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5M77_RS23155	COG1120	ATPase activity
I5M77_RS23160	COG4774	siderophore transport
I5M77_RS23165	COG1132	(ABC) transporter
I5M77_RS23170	COG2205	protein histidine kinase activity
I5M77_RS23170	COG2205	protein histidine kinase activity
I5M77_RS23180	COG0569	domain protein
I5M77_RS23185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5M77_RS23190	COG3300	MHYT domain
I5M77_RS23190	COG5001	Diguanylate cyclase
I5M77_RS23195	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I5M77_RS23200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M77_RS23215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M77_RS23215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M77_RS23215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M77_RS23220	COG2207	Transcriptional regulator
I5M77_RS23230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M77_RS23235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M77_RS23240	COG2084	Dehydrogenase
I5M77_RS23245	COG0753	catalase activity
I5M77_RS23255	COG2130	NADP-dependent
I5M77_RS23260	COG1309	transcriptional regulator
I5M77_RS23265	COG3097	Belongs to the UPF0267 family
I5M77_RS23295	COG0438	transferase activity, transferring glycosyl groups
I5M77_RS23320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5M77_RS23325	COG3842	ATPase activity
I5M77_RS23335	COG1175	transmembrane transport
I5M77_RS23340	COG3833	ABC-type maltose transport systems, permease component
I5M77_RS23360	COG3746	phosphate-selective porin O and P
I5M77_RS23375	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS23390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5M77_RS23400	COG0625	glutathione transferase activity
I5M77_RS23405	COG1686	Belongs to the peptidase S11 family
I5M77_RS23420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I5M77_RS23435	COG1278	Cold shock
I5M77_RS23440	COG1741	Belongs to the pirin family
I5M77_RS23445	COG4667	esterase of the alpha-beta hydrolase superfamily
I5M77_RS23480	COG0673	inositol 2-dehydrogenase activity
I5M77_RS23485	COG2194	sulfuric ester hydrolase activity
I5M77_RS23490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5M77_RS23500	COG2205	protein histidine kinase activity
I5M77_RS23505	COG0745	RESPONSE REGULATOR receiver
I5M77_RS23510	COG4221	oxidoreductase activity
I5M77_RS23525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M77_RS23545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5M77_RS23555	COG2814	Major facilitator Superfamily
I5M77_RS23565	COG1418	mRNA catabolic process
I5M77_RS23575	COG0402	S-adenosylhomocysteine deaminase activity
I5M77_RS23580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5M77_RS23585	COG2239	Acts as a magnesium transporter
I5M77_RS23590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I5M77_RS23605	COG0531	amino acid
I5M77_RS23610	COG1522	sequence-specific DNA binding
I5M77_RS23635	COG5002	protein histidine kinase activity
I5M77_RS23635	COG0784	Response regulator, receiver
I5M77_RS23635	COG2205	protein histidine kinase activity
I5M77_RS23640	COG0673	inositol 2-dehydrogenase activity
I5M77_RS23645	COG0534	Mate efflux family protein
I5M77_RS23650	COG2926	Belongs to the UPF0265 family
I5M77_RS23665	COG3132	Protein of unknown function, DUF480
I5M77_RS23670	COG2827	Endonuclease containing a URI domain
I5M77_RS23675	COG1879	ABC-type sugar transport system periplasmic component
I5M77_RS23680	COG0784	Response regulator, receiver
I5M77_RS23680	COG2205	protein histidine kinase activity
I5M77_RS23690	COG1566	PFAM secretion protein HlyD family protein
I5M77_RS23710	COG1522	sequence-specific DNA binding
I5M77_RS23735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M77_RS23740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M77_RS23760	COG0183	Belongs to the thiolase family
I5M77_RS23780	COG3005	denitrification pathway
I5M77_RS23790	COG0243	molybdopterin cofactor binding
I5M77_RS23800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M77_RS23805	COG3850	Histidine kinase
I5M77_RS23810	COG2197	response regulator
I5M77_RS23825	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5M77_RS23845	COG0840	transmembrane signaling receptor activity
I5M77_RS23855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M77_RS23865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M77_RS23870	COG2814	Major facilitator Superfamily
I5M77_RS23875	COG0840	transmembrane signaling receptor activity
I5M77_RS23880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M77_RS23885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M77_RS23905	COG2897	thiosulfate sulfurtransferase activity
I5M77_RS23925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M77_RS23935	COG0302	gtp cyclohydrolase
I5M77_RS23940	COG1914	H( )-stimulated, divalent metal cation uptake system
I5M77_RS23950	COG0038	chloride channel
I5M77_RS23965	COG4989	oxidoreductase activity
I5M77_RS23980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5M77_RS23980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5M77_RS23985	COG0516	GMP reductase activity
I5M77_RS23990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5M77_RS24055	COG3474	cytochrome
I5M77_RS24065	COG0789	Transcriptional regulator
I5M77_RS24070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M77_RS24075	COG0384	phenazine biosynthesis protein PhzF
I5M77_RS24085	COG1294	oxidase, subunit
I5M77_RS24090	COG1271	oxidase subunit
I5M77_RS24095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M77_RS24100	COG0110	maltose O-acetyltransferase activity
I5M77_RS24105	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I5M77_RS24105	COG3264	Mechanosensitive ion channel
I5M77_RS24120	COG4999	Histidine kinase
I5M77_RS24120	COG3850	Histidine kinase
I5M77_RS24120	COG3437	response regulator, receiver
I5M77_RS24120	COG2205	protein histidine kinase activity
I5M77_RS24130	COG4770	biotin carboxylase activity
I5M77_RS24135	COG1024	Enoyl-CoA hydratase
I5M77_RS24140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5M77_RS24145	COG1960	acyl-CoA dehydrogenase activity
I5M77_RS24155	COG0183	Belongs to the thiolase family
I5M77_RS24165	COG1960	acyl-CoA dehydrogenase activity
I5M77_RS24170	COG1024	Enoyl-CoA hydratase
I5M77_RS24185	COG1028	Short-chain dehydrogenase reductase Sdr
I5M77_RS24190	COG3706	GGDEF domain
I5M77_RS24195	COG1309	transcriptional regulator
I5M77_RS24200	COG1012	belongs to the aldehyde dehydrogenase family
I5M77_RS24215	COG4176	ABC-type proline glycine betaine transport system permease component
I5M77_RS24220	COG0517	IMP dehydrogenase activity
I5M77_RS24220	COG4175	Glycine betaine
I5M77_RS24235	COG0330	HflC and HflK could
I5M77_RS24245	COG3300	MHYT domain
I5M77_RS24245	COG5001	Diguanylate cyclase
I5M77_RS24255	COG2205	protein histidine kinase activity
I5M77_RS24255	COG0784	Response regulator, receiver
I5M77_RS24310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5M77_RS24315	COG5001	Diguanylate cyclase
I5M77_RS24320	COG1869	D-ribose catabolic process
I5M77_RS24325	COG1129	ABC transporter
I5M77_RS24330	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M77_RS24335	COG1879	ABC-type sugar transport system periplasmic component
I5M77_RS24340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M77_RS24345	COG1609	Transcriptional regulator
I5M77_RS24360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I5M77_RS24380	COG0745	RESPONSE REGULATOR receiver
I5M77_RS24395	COG1785	Belongs to the alkaline phosphatase family
I5M77_RS24420	COG0814	amino acid
I5M77_RS24430	COG0243	molybdopterin cofactor binding
I5M77_RS24450	COG3707	response regulator
I5M77_RS24455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M77_RS24455	COG1116	anion transmembrane transporter activity
I5M77_RS24460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M77_RS24465	COG1116	anion transmembrane transporter activity
I5M77_RS24470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M77_RS24470	COG2146	nitrite reductase [NAD(P)H] activity
I5M77_RS24525	COG0515	serine threonine protein kinase
I5M77_RS24525	COG2815	serine threonine protein kinase
I5M77_RS24560	COG0631	protein serine/threonine phosphatase activity
I5M77_RS24630	COG0420	3'-5' exonuclease activity
I5M77_RS24635	COG0419	ATPase involved in DNA repair
I5M77_RS24655	COG3040	lipid binding
I5M77_RS24665	COG2814	Major facilitator Superfamily
I5M77_RS24675	COG1288	antiporter activity
I5M77_RS24685	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5M77_RS24700	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I5M77_RS24715	COG0583	DNA-binding transcription factor activity
I5M77_RS24720	COG0277	FAD linked oxidase domain protein
I5M77_RS24735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5M77_RS24775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M77_RS24775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5M77_RS24810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M77_RS24815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M77_RS24825	COG2116	formate transmembrane transporter activity
I5M77_RS24845	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M77_RS24875	COG0534	Mate efflux family protein
I5M77_RS24880	COG0745	RESPONSE REGULATOR receiver
I5M77_RS24880	COG2205	protein histidine kinase activity
I5M77_RS24880	COG3292	Two component regulator propeller
I5M77_RS24890	COG3118	belongs to the thioredoxin family
I5M77_RS24895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5M77_RS24920	COG2271	Major facilitator Superfamily
I5M77_RS24925	COG3851	Histidine kinase
I5M77_RS24930	COG2197	response regulator
I5M77_RS24940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5M77_RS24945	COG0583	DNA-binding transcription factor activity
I5M77_RS24950	COG0243	molybdopterin cofactor binding
I5M77_RS24980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M77_RS24995	COG1328	CTP reductase activity
I5M77_RS25000	COG0602	queuosine metabolic process
I5M77_RS25005	COG0534	Mate efflux family protein
I5M77_RS25020	COG0189	ligase activity
I5M77_RS25020	COG4067	protein conserved in archaea
I5M77_RS25030	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M77_RS25035	COG1492	cobalamin metabolic process
I5M77_RS25040	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5M77_RS25045	COG4149	molybdate abc transporter
I5M77_RS25050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5M77_RS25060	COG5001	Diguanylate cyclase
I5M77_RS25060	COG2203	Gaf domain
I5M77_RS25060	COG3706	GGDEF domain
I5M77_RS25060	COG4251	negative regulation of phosphorylation
I5M77_RS25085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I5M77_RS25090	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I5M77_RS25115	COG3140	Belongs to the UPF0181 family
I5M77_RS25120	COG0589	response to stress
I5M77_RS25130	COG0583	DNA-binding transcription factor activity
I5M77_RS25300	COG4128	Pfam Zonular occludens toxin
I5M77_RS25345	COG4128	Pfam Zonular occludens toxin
I5M77_RS25350	COG0023	Translation Initiation Factor
I5M77_RS25360	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5M77_RS25370	COG1042	CoA-binding domain protein
I5M77_RS25370	COG0045	succinate-CoA ligase (ADP-forming) activity
I5M77_RS25370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M77_RS25375	COG0583	DNA-binding transcription factor activity
I5M77_RS25385	COG2337	Toxic component of a toxin-antitoxin (TA) module
I5M77_RS25395	COG4974	Belongs to the 'phage' integrase family
I5M77_RS25415	COG5492	domain, Protein
I5M77_RS25415	COG4932	domain protein
I5M77_RS25435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I5M77_RS25450	COG0739	heme binding
I5M77_RS25715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M77_RS25825	COG3504	Conjugal transfer protein
I5M77_RS25845	COG4962	Type ii secretion system protein e
I5M77_RS25860	COG5268	conjugation
I5M77_RS25895	COG1192	Involved in chromosome partitioning
I5M77_RS25930	COG5492	domain, Protein
I5M77_RS25930	COG4932	domain protein
I5M77_RS25970	COG2885	chlorophyll binding
I5M77_RS26025	COG1192	Involved in chromosome partitioning
I5M77_RS26050	COG0419	ATPase involved in DNA repair
I5M77_RS26295	COG4962	Type ii secretion system protein e
I5M77_RS26335	COG3504	Conjugal transfer protein
I5M77_RS26350	COG4962	Type ii secretion system protein e
I5M77_RS26360	COG3451	type IV secretory pathway VirB4
I5M77_RS26365	COG5268	conjugation