locus-tag	class	description
EPB54_RS00060	COG3209	COG3209 Rhs family protein
EPB54_RS00130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPB54_RS00175	COG1192	Involved in chromosome partitioning
EPB54_RS00350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB54_RS00440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB54_RS00455	COG0681	Belongs to the peptidase S26 family
EPB54_RS00505	COG0714	Associated with various cellular activities
EPB54_RS00570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB54_RS00645	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EPB54_RS00740	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EPB54_RS00770	COG2823	Periplasmic or secreted lipoprotein
EPB54_RS00820	COG0628	permease
EPB54_RS00835	COG1322	Protein conserved in bacteria
EPB54_RS00840	COG2226	methyltransferase
EPB54_RS00845	COG3165	ubiquinone biosynthetic process from chorismate
EPB54_RS00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPB54_RS00855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB54_RS00860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB54_RS00865	COG0805	protein transport
EPB54_RS00875	COG0084	hydrolase, TatD family'
EPB54_RS00900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB54_RS00900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB54_RS00910	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EPB54_RS00945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB54_RS00955	COG2204	response regulator
EPB54_RS00960	COG3852	Histidine kinase
EPB54_RS00970	COG0174	glutamine synthetase
EPB54_RS00975	COG1217	gtp-binding protein TYPA
EPB54_RS00990	COG1295	ribonuclease BN
EPB54_RS00995	COG1490	D-aminoacyl-tRNA deacylase activity
EPB54_RS01000	COG0456	acetyltransferase
EPB54_RS01010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EPB54_RS01015	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EPB54_RS01020	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPB54_RS01025	COG3031	protein transport across the cell outer membrane
EPB54_RS01035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB54_RS01040	COG1459	type II secretion system
EPB54_RS01045	COG2165	general secretion pathway protein
EPB54_RS01050	COG2165	general secretion pathway protein
EPB54_RS01055	COG2165	general secretion pathway protein
EPB54_RS01060	COG4795	General secretion pathway protein
EPB54_RS01065	COG3156	type II secretion system protein K
EPB54_RS01070	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB54_RS01075	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB54_RS01085	COG1218	3'(2'),5'-bisphosphate nucleotidase
EPB54_RS01090	COG0494	nUDIX hydrolase
EPB54_RS01095	COG0316	Belongs to the HesB IscA family
EPB54_RS01095	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EPB54_RS01100	COG1040	competence protein
EPB54_RS01105	COG0596	Alpha beta hydrolase
EPB54_RS01115	COG2183	response to ionizing radiation
EPB54_RS01125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB54_RS01145	COG2233	PERMEase
EPB54_RS01150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPB54_RS01155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB54_RS01160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB54_RS01165	COG1758	RNA polymerase activity
EPB54_RS01170	COG0194	GDP metabolic process
EPB54_RS01185	COG0848	biopolymer transport protein
EPB54_RS01190	COG0811	peptide transport
EPB54_RS01215	COG4174	ABC transporter (Permease)
EPB54_RS01220	COG4239	(ABC) transporter, permease
EPB54_RS01225	COG0747	negative chemotaxis
EPB54_RS01230	COG0444	Belongs to the ABC transporter superfamily
EPB54_RS01235	COG4608	Belongs to the ABC transporter superfamily
EPB54_RS01245	COG1561	YicC-like family, N-terminal region
EPB54_RS01250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EPB54_RS01255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPB54_RS01260	COG1560	Kdo2-lipid A biosynthetic process
EPB54_RS01265	COG1309	transcriptional regulator
EPB54_RS01270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPB54_RS01285	COG2003	Belongs to the UPF0758 family
EPB54_RS01290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPB54_RS01300	COG2194	sulfuric ester hydrolase activity
EPB54_RS01310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EPB54_RS01315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPB54_RS01330	COG0463	Glycosyl transferase, family 2
EPB54_RS01335	COG0859	PFAM glycosyl transferase family 9
EPB54_RS01340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB54_RS01345	COG3642	lipopolysaccharide core region biosynthetic process
EPB54_RS01355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPB54_RS01360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPB54_RS01365	COG2089	acid synthase
EPB54_RS01375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB54_RS01390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPB54_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS01420	COG1519	Transferase
EPB54_RS01425	COG0859	PFAM glycosyl transferase family 9
EPB54_RS01430	COG1560	Kdo2-lipid A biosynthetic process
EPB54_RS01440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB54_RS01480	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EPB54_RS01500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB54_RS01520	COG3594	Acyltransferase
EPB54_RS01525	COG0438	transferase activity, transferring glycosyl groups
EPB54_RS01530	COG0438	transferase activity, transferring glycosyl groups
EPB54_RS01550	COG1482	cell wall glycoprotein biosynthetic process
EPB54_RS01555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPB54_RS01570	COG0149	triose-phosphate isomerase activity
EPB54_RS01595	COG1494	fructose-1,6-bisphosphatase
EPB54_RS01605	COG3074	FtsZ-dependent cytokinesis
EPB54_RS01610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB54_RS01615	COG1575	Belongs to the MenA family. Type 1 subfamily
EPB54_RS01620	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EPB54_RS01625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EPB54_RS01635	COG1609	Transcriptional regulator
EPB54_RS01640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPB54_RS01650	COG0254	rRNA binding
EPB54_RS01660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPB54_RS01665	COG0088	Forms part of the polypeptide exit tunnel
EPB54_RS01675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPB54_RS01680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPB54_RS01685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPB54_RS01690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EPB54_RS01700	COG0255	Belongs to the universal ribosomal protein uL29 family
EPB54_RS01705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPB54_RS01710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EPB54_RS01715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPB54_RS01720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPB54_RS01725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPB54_RS01730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPB54_RS01735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPB54_RS01750	COG1841	ribosomal large subunit assembly
EPB54_RS01755	COG0200	Binds to the 23S rRNA
EPB54_RS01760	COG0201	protein transport
EPB54_RS01765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPB54_RS01770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPB54_RS01775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPB54_RS01785	COG0202	RNA polymerase activity
EPB54_RS01790	COG0203	ribosomal protein L17
EPB54_RS01800	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB54_RS01810	COG2153	protein acetylation
EPB54_RS01815	COG0513	Belongs to the DEAD box helicase family
EPB54_RS01830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPB54_RS01830	COG1648	precorrin-2 dehydrogenase activity
EPB54_RS01835	COG0175	sulfate reduction
EPB54_RS01840	COG2895	sulfate adenylyltransferase (ATP) activity
EPB54_RS01850	COG3273	potassium ion transport
EPB54_RS01850	COG0471	metal ion transport
EPB54_RS01855	COG0529	Catalyzes the synthesis of activated sulfate
EPB54_RS01875	COG4181	ATPase activity
EPB54_RS01890	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EPB54_RS01900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB54_RS01905	COG0729	surface antigen
EPB54_RS01910	COG2911	Protein conserved in bacteria
EPB54_RS01915	COG2105	PFAM AIG2 family protein
EPB54_RS01925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPB54_RS01930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPB54_RS01940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB54_RS01945	COG0163	prenyltransferase activity
EPB54_RS01950	COG4143	(ABC) transporter
EPB54_RS01955	COG1178	ABC-type Fe3 transport system permease component
EPB54_RS01960	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EPB54_RS01980	COG2358	TRAP transporter, solute receptor (TAXI family
EPB54_RS01995	COG0039	L-malate dehydrogenase activity
EPB54_RS02005	COG0142	geranyltranstransferase activity
EPB54_RS02010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPB54_RS02020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPB54_RS02025	COG2966	Psort location CytoplasmicMembrane, score
EPB54_RS02040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPB54_RS02045	COG2967	ApaG domain
EPB54_RS02050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPB54_RS02055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPB54_RS02060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB54_RS02065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EPB54_RS02070	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB54_RS02080	COG0066	3-isopropylmalate dehydratase activity
EPB54_RS02085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPB54_RS02090	COG0473	3-isopropylmalate dehydrogenase activity
EPB54_RS02095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPB54_RS02120	COG0583	DNA-binding transcription factor activity
EPB54_RS02125	COG1022	Amp-dependent synthetase and ligase
EPB54_RS02130	COG0028	Belongs to the TPP enzyme family
EPB54_RS02135	COG0440	acetolactate synthase activity
EPB54_RS02150	COG0469	pyruvate kinase activity
EPB54_RS02160	COG1349	DNA-binding transcription factor activity
EPB54_RS02165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPB54_RS02180	COG5002	protein histidine kinase activity
EPB54_RS02185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB54_RS02190	COG3722	fumarate hydratase activity
EPB54_RS02195	COG0246	Mannitol dehydrogenase
EPB54_RS02200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB54_RS02200	COG2213	PTS system mannitol-specific
EPB54_RS02235	COG1464	Belongs to the NlpA lipoprotein family
EPB54_RS02250	COG0358	DNA primase activity
EPB54_RS02255	COG1610	YqeY-like protein
EPB54_RS02260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPB54_RS02265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPB54_RS02270	COG0596	Alpha beta hydrolase
EPB54_RS02275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPB54_RS02280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPB54_RS02285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB54_RS02290	COG1968	undecaprenyl-diphosphatase activity
EPB54_RS02295	COG0617	tRNA 3'-terminal CCA addition
EPB54_RS02300	COG3267	Type II secretory pathway component ExeA
EPB54_RS02300	COG3409	Peptidoglycan-binding domain 1 protein
EPB54_RS02310	COG4991	sh3 domain protein
EPB54_RS02315	COG0306	phosphate transporter
EPB54_RS02320	COG1392	Phosphate transport regulator
EPB54_RS02325	COG3025	triphosphatase activity
EPB54_RS02340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EPB54_RS02345	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPB54_RS02345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPB54_RS02350	COG1538	Outer membrane efflux protein
EPB54_RS02355	COG0494	nUDIX hydrolase
EPB54_RS02360	COG3151	Protein conserved in bacteria
EPB54_RS02370	COG3150	esterase
EPB54_RS02380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EPB54_RS02385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPB54_RS02395	COG3105	Protein conserved in bacteria
EPB54_RS02405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPB54_RS02415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPB54_RS02420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPB54_RS02425	COG0723	plastoquinol--plastocyanin reductase activity
EPB54_RS02430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EPB54_RS02435	COG2857	Cytochrome c1
EPB54_RS02440	COG0625	glutathione transferase activity
EPB54_RS02445	COG2969	positive regulation of protein catabolic process
EPB54_RS02450	COG2823	Periplasmic or secreted lipoprotein
EPB54_RS02455	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB54_RS02460	COG0792	nuclease activity
EPB54_RS02470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPB54_RS02485	COG0275	rRNA processing
EPB54_RS02490	COG3116	cell division
EPB54_RS02495	COG0768	penicillin binding
EPB54_RS02500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPB54_RS02505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPB54_RS02510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPB54_RS02515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPB54_RS02520	COG0772	Belongs to the SEDS family
EPB54_RS02525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPB54_RS02530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB54_RS02535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPB54_RS02540	COG0849	cell division
EPB54_RS02545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPB54_RS02550	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPB54_RS02560	COG0653	protein targeting
EPB54_RS02565	COG0494	nUDIX hydrolase
EPB54_RS02570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EPB54_RS02575	COG0505	Belongs to the CarA family
EPB54_RS02580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPB54_RS02595	COG0730	response to heat
EPB54_RS02600	COG0583	DNA-binding transcription factor activity
EPB54_RS02605	COG2860	membrane
EPB54_RS02610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB54_RS02620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB54_RS02630	COG0493	'glutamate synthase
EPB54_RS02635	COG0067	glutamate synthase
EPB54_RS02635	COG0070	glutamate synthase
EPB54_RS02635	COG0069	glutamate synthase activity
EPB54_RS02645	COG0067	glutamate synthase
EPB54_RS02645	COG0069	glutamate synthase activity
EPB54_RS02645	COG0070	glutamate synthase
EPB54_RS02650	COG1242	4 iron, 4 sulfur cluster binding
EPB54_RS02655	COG4251	negative regulation of phosphorylation
EPB54_RS02655	COG3706	GGDEF domain
EPB54_RS02655	COG5001	Diguanylate cyclase
EPB54_RS02655	COG2203	Gaf domain
EPB54_RS02660	COG5002	protein histidine kinase activity
EPB54_RS02660	COG2198	Histidine kinase
EPB54_RS02660	COG0784	Response regulator, receiver
EPB54_RS02670	COG0745	RESPONSE REGULATOR receiver
EPB54_RS02685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB54_RS02700	COG0083	homoserine kinase activity
EPB54_RS02705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPB54_RS02710	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EPB54_RS02715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EPB54_RS02725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPB54_RS02740	COG1115	amino acid carrier protein
EPB54_RS02745	COG3022	response to hydroperoxide
EPB54_RS02750	COG0513	Belongs to the DEAD box helicase family
EPB54_RS02755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EPB54_RS02765	COG0716	FMN binding
EPB54_RS02770	COG4974	Belongs to the 'phage' integrase family
EPB54_RS02775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB54_RS02780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPB54_RS02790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPB54_RS02795	COG2204	response regulator
EPB54_RS02805	COG0667	Aldo Keto reductase
EPB54_RS02815	COG3066	DNA modification
EPB54_RS02825	COG0494	nUDIX hydrolase
EPB54_RS02835	COG0730	response to heat
EPB54_RS02840	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPB54_RS02845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPB54_RS02855	COG1283	sodium-dependent phosphate transmembrane transporter activity
EPB54_RS02860	COG0583	DNA-binding transcription factor activity
EPB54_RS02870	COG0640	Transcriptional regulator
EPB54_RS02880	COG0268	Binds directly to 16S ribosomal RNA
EPB54_RS02885	COG0728	peptidoglycan biosynthetic process
EPB54_RS02890	COG0196	riboflavin kinase activity
EPB54_RS02895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPB54_RS02900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EPB54_RS02905	COG1047	Peptidyl-prolyl cis-trans
EPB54_RS02910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPB54_RS02915	COG3279	Response regulator of the LytR AlgR family
EPB54_RS02920	COG3275	phosphorelay sensor kinase activity
EPB54_RS02925	COG1966	Carbon starvation protein
EPB54_RS02940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPB54_RS02945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPB54_RS02950	COG1472	Belongs to the glycosyl hydrolase 3 family
EPB54_RS02955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB54_RS02960	COG0287	Prephenate dehydrogenase
EPB54_RS02960	COG1605	Chorismate mutase
EPB54_RS02965	COG0739	heme binding
EPB54_RS02980	COG0488	(ABC) transporter
EPB54_RS02990	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EPB54_RS02995	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EPB54_RS03000	COG0077	Prephenate dehydratase
EPB54_RS03000	COG1605	Chorismate mutase
EPB54_RS03005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB54_RS03010	COG0741	lytic transglycosylase activity
EPB54_RS03015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB54_RS03020	COG0564	pseudouridine synthase activity
EPB54_RS03025	COG1496	oxidoreductase activity
EPB54_RS03030	COG0542	response to heat
EPB54_RS03090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB54_RS03095	COG0826	peptidase U32
EPB54_RS03100	COG2974	May be involved in recombination
EPB54_RS03105	COG0745	RESPONSE REGULATOR receiver
EPB54_RS03110	COG5002	protein histidine kinase activity
EPB54_RS03120	COG0248	Ppx GppA phosphatase
EPB54_RS03125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPB54_RS03135	COG0581	inorganic phosphate transmembrane transporter activity
EPB54_RS03140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB54_RS03145	COG0704	Plays a role in the regulation of phosphate uptake
EPB54_RS03155	COG3142	Participates in the control of copper homeostasis
EPB54_RS03160	COG0450	alkyl hydroperoxide reductase
EPB54_RS03165	COG0583	DNA-binding transcription factor activity
EPB54_RS03175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPB54_RS03185	COG0517	IMP dehydrogenase activity
EPB54_RS03195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPB54_RS03200	COG0343	queuine tRNA-ribosyltransferase activity
EPB54_RS03205	COG1862	Preprotein translocase
EPB54_RS03210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB54_RS03215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB54_RS03225	COG0483	inositol monophosphate 1-phosphatase activity
EPB54_RS03240	COG1104	cysteine desulfurase activity
EPB54_RS03245	COG0822	iron-sulfur transferase activity
EPB54_RS03255	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB54_RS03260	COG0443	Heat shock 70 kDa protein
EPB54_RS03265	COG0633	Ferredoxin
EPB54_RS03270	COG2975	iron-sulfur cluster assembly
EPB54_RS03275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB54_RS03280	COG0105	UTP biosynthetic process
EPB54_RS03285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EPB54_RS03300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPB54_RS03305	COG0124	histidyl-tRNA synthetase
EPB54_RS03310	COG2976	Protein conserved in bacteria
EPB54_RS03315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB54_RS03320	COG1160	GTP binding
EPB54_RS03335	COG1570	exodeoxyribonuclease VII activity
EPB54_RS03340	COG0517	IMP dehydrogenase activity
EPB54_RS03340	COG0516	GMP reductase activity
EPB54_RS03345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPB54_RS03345	COG0519	Catalyzes the synthesis of GMP from XMP
EPB54_RS03350	COG1757	Na H antiporter
EPB54_RS03360	COG1584	GPR1 FUN34 yaaH family protein
EPB54_RS03370	COG1115	amino acid carrier protein
EPB54_RS03405	COG2873	o-acetylhomoserine
EPB54_RS03410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPB54_RS03430	COG3153	acetyltransferase
EPB54_RS03430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB54_RS03435	COG0583	DNA-binding transcription factor activity
EPB54_RS03460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPB54_RS03495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EPB54_RS03500	COG2867	negative regulation of translational initiation
EPB54_RS03505	COG2914	Belongs to the UPF0125 (RnfH) family
EPB54_RS03510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB54_RS03515	COG0497	DNA recombination
EPB54_RS03525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPB54_RS03530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPB54_RS03540	COG0443	Heat shock 70 kDa protein
EPB54_RS03545	COG0484	heat shock protein binding
EPB54_RS03585	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB54_RS03600	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EPB54_RS03610	COG0047	phosphoribosylformylglycinamidine synthase activity
EPB54_RS03610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPB54_RS03635	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB54_RS03640	COG2252	PERMEase
EPB54_RS03645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EPB54_RS03650	COG1073	alpha beta
EPB54_RS03660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EPB54_RS03665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPB54_RS03670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPB54_RS03675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB54_RS03675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB54_RS03695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB54_RS03700	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPB54_RS03705	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EPB54_RS03710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPB54_RS03715	COG0142	geranyltranstransferase activity
EPB54_RS03720	COG1722	exodeoxyribonuclease VII activity
EPB54_RS03725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB54_RS03730	COG2885	chlorophyll binding
EPB54_RS03735	COG0301	tRNA thio-modification
EPB54_RS03735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB54_RS03740	COG0583	DNA-binding transcription factor activity
EPB54_RS03750	COG2363	Small membrane protein
EPB54_RS03755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EPB54_RS03765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB54_RS03770	COG1611	Belongs to the LOG family
EPB54_RS03785	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB54_RS03785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB54_RS03795	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EPB54_RS03800	COG1464	Belongs to the NlpA lipoprotein family
EPB54_RS03805	COG2011	ABC-type metal ion transport system permease component
EPB54_RS03810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPB54_RS03820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB54_RS03830	COG1263	PTS System
EPB54_RS03830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB54_RS03835	COG0366	Alpha amylase catalytic
EPB54_RS03850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EPB54_RS03855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB54_RS03860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPB54_RS03865	COG0321	lipoyl(octanoyl) transferase activity
EPB54_RS03870	COG2921	Belongs to the UPF0250 family
EPB54_RS03875	COG1686	Belongs to the peptidase S11 family
EPB54_RS03880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPB54_RS03885	COG0772	Belongs to the SEDS family
EPB54_RS03890	COG0768	penicillin binding
EPB54_RS03895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EPB54_RS03900	COG0799	negative regulation of ribosome biogenesis
EPB54_RS03905	COG1466	dna polymerase III delta subunit
EPB54_RS03910	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EPB54_RS03915	COG0495	leucyl-tRNA aminoacylation
EPB54_RS03920	COG2888	peptidyl-tyrosine sulfation
EPB54_RS03925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPB54_RS03930	COG4535	Mg2 and Co2 transporter CorC
EPB54_RS03935	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPB54_RS03940	COG1702	phosphate starvation-inducible protein PhoH
EPB54_RS03945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPB54_RS03955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB54_RS04070	COG0012	GTP binding
EPB54_RS04075	COG0193	aminoacyl-tRNA hydrolase activity
EPB54_RS04080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPB54_RS04085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EPB54_RS04090	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EPB54_RS04095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPB54_RS04100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPB54_RS04105	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB54_RS04110	COG3094	Invasion gene expression up-regulator, SirB
EPB54_RS04115	COG2912	Transglutaminase-like superfamily
EPB54_RS04120	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPB54_RS04125	COG0737	Belongs to the 5'-nucleotidase family
EPB54_RS04135	COG1187	pseudouridine synthase activity
EPB54_RS04140	COG2840	Smr protein MutS2
EPB54_RS04180	COG2217	Heavy metal translocating P-type atpase
EPB54_RS04180	COG2608	mercury ion transmembrane transporter activity
EPB54_RS04195	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB54_RS04200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB54_RS04260	COG0784	Response regulator, receiver
EPB54_RS04260	COG0835	chemotaxis
EPB54_RS04265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPB54_RS04270	COG1815	bacterial-type flagellum-dependent cell motility
EPB54_RS04275	COG1558	bacterial-type flagellum-dependent cell motility
EPB54_RS04285	COG1749	Flagellar hook protein flgE
EPB54_RS04295	COG4787	bacterial-type flagellum-dependent cell motility
EPB54_RS04305	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB54_RS04310	COG1706	bacterial-type flagellum-dependent cell motility
EPB54_RS04315	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPB54_RS04315	COG3951	Flagellar rod assembly protein muramidase FlgJ
EPB54_RS04325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS04335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS04345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS04350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS04360	COG2190	(PTS) system
EPB54_RS04365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB54_RS04370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB54_RS04380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPB54_RS04385	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EPB54_RS04390	COG3115	cell septum assembly
EPB54_RS04395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPB54_RS04420	COG0330	HflC and HflK could
EPB54_RS04425	COG3118	belongs to the thioredoxin family
EPB54_RS04435	COG0300	oxidoreductase activity
EPB54_RS04440	COG1090	epimerase
EPB54_RS04470	COG0622	Phosphoesterase
EPB54_RS04490	COG3710	Transcriptional regulator
EPB54_RS04495	COG0326	Molecular chaperone. Has ATPase activity
EPB54_RS04500	COG0563	adenylate kinase activity
EPB54_RS04505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPB54_RS04510	COG3104	oligopeptide transport
EPB54_RS04515	COG0250	Participates in transcription elongation, termination and antitermination
EPB54_RS04520	COG0367	asparagine synthase
EPB54_RS04525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB54_RS04525	COG4651	solute:proton antiporter activity
EPB54_RS04530	COG1940	carbohydrate kinase activity
EPB54_RS04530	COG1846	Transcriptional regulator
EPB54_RS04535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPB54_RS04545	COG1263	PTS System
EPB54_RS04545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB54_RS04550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB54_RS04555	COG0735	belongs to the Fur family
EPB54_RS04565	COG0716	FMN binding
EPB54_RS04575	COG0596	Alpha beta hydrolase
EPB54_RS04580	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EPB54_RS04585	COG0033	Phosphoglucomutase
EPB54_RS04595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPB54_RS04610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPB54_RS04615	COG1053	succinate dehydrogenase
EPB54_RS04620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB54_RS04625	COG0567	Dehydrogenase, E1 component
EPB54_RS04630	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB54_RS04635	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB54_RS04645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB54_RS04650	COG1121	(ABC) transporter
EPB54_RS04655	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EPB54_RS04660	COG4977	sequence-specific DNA binding
EPB54_RS04675	COG1918	ferrous iron import across plasma membrane
EPB54_RS04695	COG0018	arginyl-trna synthetase
EPB54_RS04705	COG3102	Protein conserved in bacteria
EPB54_RS04710	COG0788	formyltetrahydrofolate deformylase activity
EPB54_RS04715	COG1199	ATP-dependent helicase activity
EPB54_RS04720	COG1214	PFAM Peptidase M22, glycoprotease
EPB54_RS04735	COG2267	carboxylic ester hydrolase activity
EPB54_RS04740	COG0318	PFAM AMP-dependent synthetase and ligase
EPB54_RS04745	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EPB54_RS04750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EPB54_RS04755	COG2894	cell division
EPB54_RS04760	COG0850	regulation of cytokinetic process
EPB54_RS04765	COG3100	YcgL domain-containing protein
EPB54_RS04770	COG2951	lytic endotransglycosylase activity
EPB54_RS04775	COG0583	DNA-binding transcription factor activity
EPB54_RS04780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB54_RS04785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPB54_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS04815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB54_RS04840	COG2986	histidine ammonia-lyase
EPB54_RS04845	COG1216	Glycosyl transferase, family 2
EPB54_RS04850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB54_RS04865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB54_RS04870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB54_RS04905	COG1253	flavin adenine dinucleotide binding
EPB54_RS04910	COG0513	Belongs to the DEAD box helicase family
EPB54_RS04915	COG0569	domain protein
EPB54_RS04920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB54_RS04940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPB54_RS04945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB54_RS04950	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB54_RS04955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB54_RS04965	COG2204	response regulator
EPB54_RS04975	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPB54_RS04985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPB54_RS04990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPB54_RS04995	COG0776	regulation of translation
EPB54_RS05000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB54_RS05005	COG1555	photosystem II stabilization
EPB54_RS05020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EPB54_RS05025	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EPB54_RS05030	COG0436	Aminotransferase
EPB54_RS05035	COG1169	isochorismate synthase
EPB54_RS05040	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EPB54_RS05045	COG0596	Alpha beta hydrolase
EPB54_RS05050	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EPB54_RS05070	COG2855	membrane
EPB54_RS05075	COG0477	Major facilitator Superfamily
EPB54_RS05130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB54_RS05160	COG1522	sequence-specific DNA binding
EPB54_RS05170	COG1946	Acyl-CoA thioesterase
EPB54_RS05175	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EPB54_RS05190	COG2199	diguanylate cyclase activity
EPB54_RS05200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB54_RS05205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EPB54_RS05210	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EPB54_RS05220	COG0517	IMP dehydrogenase activity
EPB54_RS05220	COG0516	GMP reductase activity
EPB54_RS05250	COG0537	adenosine 5'-monophosphoramidase activity
EPB54_RS05275	COG3150	esterase
EPB54_RS05285	COG1252	NADH dehydrogenase
EPB54_RS05300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPB54_RS05310	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB54_RS05315	COG1136	(ABC) transporter
EPB54_RS05320	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB54_RS05330	COG2333	competence protein COMEC
EPB54_RS05330	COG0658	competence protein
EPB54_RS05335	COG1132	(ABC) transporter
EPB54_RS05340	COG1663	tetraacyldisaccharide 4'-kinase activity
EPB54_RS05350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPB54_RS05355	COG2719	SpoVR family
EPB54_RS05360	COG2718	Belongs to the UPF0229 family
EPB54_RS05365	COG2766	serine protein kinase
EPB54_RS05375	COG3013	Belongs to the UPF0304 family
EPB54_RS05385	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB54_RS05395	COG1882	Formate acetyltransferase
EPB54_RS05440	COG0708	Exodeoxyribonuclease III
EPB54_RS05450	COG3923	Primosomal replication protein n
EPB54_RS05455	COG0730	response to heat
EPB54_RS05460	COG1199	ATP-dependent helicase activity
EPB54_RS05470	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB54_RS05475	COG1187	pseudouridine synthase activity
EPB54_RS05485	COG1278	Cold shock
EPB54_RS05490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPB54_RS05495	COG0542	response to heat
EPB54_RS05505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPB54_RS05510	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EPB54_RS05515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPB54_RS05525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EPB54_RS05535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB54_RS05540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB54_RS05545	COG0297	glycogen (starch) synthase activity
EPB54_RS05565	COG3070	regulator of competence-specific genes
EPB54_RS05570	COG1609	Transcriptional regulator
EPB54_RS05575	COG3381	protein complex oligomerization
EPB54_RS05580	COG0745	RESPONSE REGULATOR receiver
EPB54_RS05585	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB54_RS05590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB54_RS05595	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EPB54_RS05600	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EPB54_RS05605	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EPB54_RS05625	COG4067	protein conserved in archaea
EPB54_RS05625	COG0189	ligase activity
EPB54_RS05635	COG0500	methyltransferase
EPB54_RS05640	COG4106	trans-aconitate 2-methyltransferase activity
EPB54_RS05645	COG1801	Protein of unknown function DUF72
EPB54_RS05650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EPB54_RS05655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EPB54_RS05660	COG0840	transmembrane signaling receptor activity
EPB54_RS05665	COG0632	four-way junction helicase activity
EPB54_RS05670	COG2255	four-way junction helicase activity
EPB54_RS05675	COG1271	oxidase subunit
EPB54_RS05680	COG1294	oxidase, subunit
EPB54_RS05685	COG4890	Cyd operon protein YbgT
EPB54_RS05695	COG0824	Thioesterase
EPB54_RS05700	COG0811	peptide transport
EPB54_RS05715	COG0823	Involved in the tonB-independent uptake of proteins
EPB54_RS05720	COG2885	chlorophyll binding
EPB54_RS05725	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EPB54_RS05730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPB54_RS05740	COG3766	membrane
EPB54_RS05750	COG0754	glutathionylspermidine amidase activity
EPB54_RS05760	COG5002	protein histidine kinase activity
EPB54_RS05760	COG0784	Response regulator, receiver
EPB54_RS05795	COG0840	transmembrane signaling receptor activity
EPB54_RS05810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB54_RS05815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB54_RS05845	COG3568	Endonuclease Exonuclease Phosphatase
EPB54_RS05860	COG0583	DNA-binding transcription factor activity
EPB54_RS05870	COG0686	Belongs to the AlaDH PNT family
EPB54_RS05880	COG1674	ftsk spoiiie
EPB54_RS05885	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EPB54_RS05890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPB54_RS05895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPB54_RS05910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPB54_RS05915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPB54_RS05920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPB54_RS05925	COG0156	8-amino-7-oxononanoate synthase activity
EPB54_RS05935	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EPB54_RS05945	COG0501	Belongs to the peptidase M48B family
EPB54_RS05955	COG0300	oxidoreductase activity
EPB54_RS05970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPB54_RS05995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPB54_RS06000	COG2915	High frequency lysogenization protein hflD homolog
EPB54_RS06005	COG0482	sulfurtransferase activity
EPB54_RS06015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB54_RS06025	COG1757	Na H antiporter
EPB54_RS06040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPB54_RS06045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPB54_RS06050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EPB54_RS06055	COG0131	Imidazoleglycerol-phosphate dehydratase
EPB54_RS06055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB54_RS06060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPB54_RS06065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPB54_RS06070	COG0107	imidazoleglycerol-phosphate synthase activity
EPB54_RS06075	COG0140	phosphoribosyl-ATP diphosphatase activity
EPB54_RS06075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPB54_RS06080	COG3012	SEC-C Motif Domain Protein
EPB54_RS06090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB54_RS06095	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB54_RS06100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB54_RS06105	COG0215	cysteine-tRNA ligase activity
EPB54_RS06110	COG1435	thymidine kinase activity
EPB54_RS06115	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB54_RS06140	COG2116	formate transmembrane transporter activity
EPB54_RS06150	COG0390	transport system, permease component
EPB54_RS06155	COG4459	periplasmic nitrate reductase
EPB54_RS06160	COG3005	denitrification pathway
EPB54_RS06165	COG0243	molybdopterin cofactor binding
EPB54_RS06180	COG1227	inorganic diphosphatase activity
EPB54_RS06190	COG4172	Belongs to the ABC transporter superfamily
EPB54_RS06200	COG4171	peptide transport system, permease
EPB54_RS06215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EPB54_RS06220	COG1842	Phage shock protein A
EPB54_RS06230	COG1983	PspC domain protein
EPB54_RS06235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB54_RS06250	COG2818	Glycosylase
EPB54_RS06255	COG5380	lipid catabolic process
EPB54_RS06260	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPB54_RS06265	COG0626	cystathionine gamma-synthase activity
EPB54_RS06275	COG0733	neurotransmitter:sodium symporter activity
EPB54_RS06285	COG0564	pseudouridine synthase activity
EPB54_RS06295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB54_RS06300	COG1151	hydroxylamine reductase activity
EPB54_RS06305	COG3604	Transcriptional regulator
EPB54_RS06320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPB54_RS06325	COG4136	ATPase activity
EPB54_RS06330	COG4135	transport system, permease component
EPB54_RS06335	COG4134	Bacterial extracellular solute-binding protein
EPB54_RS06340	COG0398	Pfam SNARE associated Golgi protein
EPB54_RS06350	COG0493	'glutamate synthase
EPB54_RS06375	COG3313	Fe-S protein
EPB54_RS06405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPB54_RS06425	COG1061	Type III restriction enzyme res subunit
EPB54_RS06430	COG1187	pseudouridine synthase activity
EPB54_RS06435	COG2814	Major facilitator Superfamily
EPB54_RS06465	COG3005	denitrification pathway
EPB54_RS06470	COG0702	epimerase
EPB54_RS06475	COG0534	Mate efflux family protein
EPB54_RS06480	COG4181	ATPase activity
EPB54_RS06495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB54_RS06510	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB54_RS06515	COG2985	domain, Protein
EPB54_RS06515	COG3273	potassium ion transport
EPB54_RS06520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB54_RS06535	COG1737	Transcriptional regulator
EPB54_RS06540	COG0076	glutamate decarboxylase activity
EPB54_RS06550	COG2431	L-lysine efflux transmembrane transporter activity
EPB54_RS06565	COG3070	regulator of competence-specific genes
EPB54_RS06580	COG4191	Histidine kinase
EPB54_RS06580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB54_RS06590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EPB54_RS06595	COG3048	D-serine ammonia-lyase activity
EPB54_RS06600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPB54_RS06605	COG4988	ABC transporter
EPB54_RS06610	COG0492	ferredoxin-NADP+ reductase activity
EPB54_RS06635	COG0471	metal ion transport
EPB54_RS06640	COG2949	membrane
EPB54_RS06645	COG0281	malic enzyme
EPB54_RS06655	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
EPB54_RS06670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPB54_RS06705	COG0277	FAD linked oxidase domain protein
EPB54_RS06705	COG0247	lactate metabolic process
EPB54_RS06720	COG2986	histidine ammonia-lyase
EPB54_RS06725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EPB54_RS06730	COG0010	Belongs to the arginase family
EPB54_RS06735	COG1228	amidohydrolase
EPB54_RS06740	COG2188	Transcriptional regulator
EPB54_RS06755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPB54_RS06765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPB54_RS06775	COG0393	Putative heavy-metal-binding
EPB54_RS06805	COG3706	GGDEF domain
EPB54_RS06810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPB54_RS06815	COG0072	phenylalanine-tRNA ligase activity
EPB54_RS06815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB54_RS06830	COG0776	regulation of translation
EPB54_RS06840	COG0500	methyltransferase
EPB54_RS06845	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EPB54_RS06850	COG0295	cytidine deaminase activity
EPB54_RS06855	COG1346	cytolysis
EPB54_RS06860	COG1380	Effector of murein hydrolase LrgA
EPB54_RS06865	COG2925	Exonuclease
EPB54_RS06870	COG1823	symporter activity
EPB54_RS06875	COG0702	epimerase
EPB54_RS06880	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EPB54_RS06885	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EPB54_RS06895	COG2062	phosphohistidine phosphatase, SixA
EPB54_RS06910	COG2988	succinylglutamate desuccinylase activity
EPB54_RS06915	COG4139	cobalamin transport
EPB54_RS06920	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EPB54_RS06940	COG0583	DNA-binding transcription factor activity
EPB54_RS06960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPB54_RS06965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB54_RS06970	COG3475	LICD family
EPB54_RS06975	COG1451	nucleotide metabolic process
EPB54_RS06980	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EPB54_RS07010	COG3938	Belongs to the proline racemase family
EPB54_RS07030	COG2423	ornithine cyclodeaminase activity
EPB54_RS07035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPB54_RS07040	COG3842	ATPase activity
EPB54_RS07045	COG1176	ABC-type spermidine putrescine transport system, permease component I
EPB54_RS07050	COG1177	transmembrane transport
EPB54_RS07060	COG3291	Pkd domain containing protein
EPB54_RS07080	COG0444	Belongs to the ABC transporter superfamily
EPB54_RS07085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB54_RS07090	COG0601	transmembrane transport
EPB54_RS07100	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB54_RS07110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EPB54_RS07120	COG0625	glutathione transferase activity
EPB54_RS07215	COG2732	(Barnase) inhibitor
EPB54_RS07315	COG1783	phage Terminase large subunit
EPB54_RS07485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPB54_RS07490	COG1127	ABC transporter
EPB54_RS07505	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EPB54_RS07505	COG3264	Mechanosensitive ion channel
EPB54_RS07535	COG0531	amino acid
EPB54_RS07545	COG0531	amino acid
EPB54_RS07555	COG1982	Orn Lys Arg decarboxylase major
EPB54_RS07560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EPB54_RS07575	COG0583	DNA-binding transcription factor activity
EPB54_RS07580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB54_RS07610	COG0471	metal ion transport
EPB54_RS07615	COG4191	Histidine kinase
EPB54_RS07615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB54_RS07625	COG5001	Diguanylate cyclase
EPB54_RS07625	COG3300	MHYT domain
EPB54_RS07635	COG1280	lysine exporter protein (LysE YggA)
EPB54_RS07640	COG1328	CTP reductase activity
EPB54_RS07645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB54_RS07655	COG0861	Integral membrane protein TerC family
EPB54_RS07665	COG0739	heme binding
EPB54_RS07705	COG3501	Rhs element vgr protein
EPB54_RS07730	COG0515	serine threonine protein kinase
EPB54_RS07765	COG1522	sequence-specific DNA binding
EPB54_RS07835	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB54_RS07850	COG0814	amino acid
EPB54_RS07875	COG1132	(ABC) transporter
EPB54_RS07880	COG1132	(ABC) transporter
EPB54_RS07910	COG0443	Heat shock 70 kDa protein
EPB54_RS07915	COG0443	Heat shock 70 kDa protein
EPB54_RS07925	COG3706	GGDEF domain
EPB54_RS07955	COG0243	molybdopterin cofactor binding
EPB54_RS07960	COG0437	4 iron, 4 sulfur cluster binding
EPB54_RS07965	COG3302	dmso reductase anchor subunit
EPB54_RS07980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPB54_RS07985	COG1643	Atp-dependent helicase
EPB54_RS08000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB54_RS08010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB54_RS08015	COG1215	transferase activity, transferring glycosyl groups
EPB54_RS08020	COG0438	transferase activity, transferring glycosyl groups
EPB54_RS08055	COG0438	transferase activity, transferring glycosyl groups
EPB54_RS08065	COG2204	response regulator
EPB54_RS08100	COG1793	dna ligase
EPB54_RS08110	COG0534	Mate efflux family protein
EPB54_RS08115	COG0307	riboflavin synthase, alpha
EPB54_RS08125	COG3001	Fructosamine kinase
EPB54_RS08130	COG2201	protein-glutamate methylesterase activity
EPB54_RS08135	COG3706	GGDEF domain
EPB54_RS08145	COG0791	NLP P60 protein
EPB54_RS08150	COG3290	protein histidine kinase activity
EPB54_RS08150	COG0840	transmembrane signaling receptor activity
EPB54_RS08185	COG3148	PFAM DTW domain containing protein
EPB54_RS08190	COG1940	carbohydrate kinase activity
EPB54_RS08200	COG0303	'Molybdopterin
EPB54_RS08205	COG0746	molybdenum cofactor guanylyltransferase activity
EPB54_RS08210	COG3842	ATPase activity
EPB54_RS08230	COG2204	response regulator
EPB54_RS08235	COG4191	Histidine kinase
EPB54_RS08245	COG0488	(ABC) transporter
EPB54_RS08250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPB54_RS08275	COG3381	protein complex oligomerization
EPB54_RS08285	COG3383	formate dehydrogenase (NAD+) activity
EPB54_RS08285	COG0243	molybdopterin cofactor binding
EPB54_RS08290	COG0437	4 iron, 4 sulfur cluster binding
EPB54_RS08330	COG0004	ammonium transporteR
EPB54_RS08340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPB54_RS08345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EPB54_RS08355	COG1177	transmembrane transport
EPB54_RS08365	COG3842	ATPase activity
EPB54_RS08385	COG0037	tRNA processing
EPB54_RS08395	COG0589	response to stress
EPB54_RS08400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB54_RS08415	COG2217	Heavy metal translocating P-type atpase
EPB54_RS08425	COG2010	Cytochrome c
EPB54_RS08440	COG3278	Belongs to the heme-copper respiratory oxidase family
EPB54_RS08455	COG0784	Response regulator, receiver
EPB54_RS08455	COG2205	protein histidine kinase activity
EPB54_RS08475	COG3120	sequence-specific DNA binding
EPB54_RS08480	COG1067	ATP-dependent peptidase activity
EPB54_RS08485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB54_RS08500	COG0488	(ABC) transporter
EPB54_RS08510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB54_RS08510	COG0116	Belongs to the methyltransferase superfamily
EPB54_RS08525	COG0167	dihydroorotate dehydrogenase activity
EPB54_RS08530	COG2902	Dehydrogenase
EPB54_RS08540	COG0308	aminopeptidase N
EPB54_RS08555	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EPB54_RS08560	COG1956	GAF domain-containing protein
EPB54_RS08565	COG1132	(ABC) transporter
EPB54_RS08570	COG2995	paraquat-inducible protein a
EPB54_RS08575	COG3008	intermembrane lipid transfer
EPB54_RS08580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPB54_RS08580	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EPB54_RS08600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB54_RS08605	COG1666	GTP binding
EPB54_RS08620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB54_RS08625	COG4597	amino acid ABC transporter
EPB54_RS08630	COG0765	amino acid transport
EPB54_RS08635	COG1126	abc transporter atp-binding protein
EPB54_RS08640	COG0670	Belongs to the BI1 family
EPB54_RS08650	COG2920	part of a sulfur-relay system
EPB54_RS08655	COG1254	Belongs to the acylphosphatase family
EPB54_RS08665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB54_RS08705	COG3706	GGDEF domain
EPB54_RS08710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPB54_RS08715	COG0602	queuosine metabolic process
EPB54_RS08720	COG0561	phosphatase activity
EPB54_RS08745	COG2828	Protein conserved in bacteria
EPB54_RS08755	COG0372	Belongs to the citrate synthase family
EPB54_RS08760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EPB54_RS08790	COG0730	response to heat
EPB54_RS08810	COG0457	Tetratricopeptide repeat
EPB54_RS08880	COG4790	Type iii secretion
EPB54_RS08885	COG4794	Type iii secretion
EPB54_RS08890	COG4791	protein targeting
EPB54_RS08895	COG4792	protein secretion
EPB54_RS08945	COG3177	Filamentation induced by cAMP protein fic
EPB54_RS08965	COG4669	(LipO)protein
EPB54_RS09035	COG1012	belongs to the aldehyde dehydrogenase family
EPB54_RS09040	COG3284	Transcriptional regulator
EPB54_RS09055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB54_RS09060	COG0363	glucosamine-6-phosphate deaminase activity
EPB54_RS09065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPB54_RS09070	COG4565	transcriptional regulatory protein
EPB54_RS09075	COG3290	protein histidine kinase activity
EPB54_RS09090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB54_RS09105	COG1858	cytochrome C peroxidase
EPB54_RS09110	COG0527	aspartate kinase activity
EPB54_RS09115	COG0662	Cupin 2, conserved barrel domain protein
EPB54_RS09120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB54_RS09125	COG0456	acetyltransferase
EPB54_RS09130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB54_RS09150	COG4176	ABC-type proline glycine betaine transport system permease component
EPB54_RS09155	COG2113	Glycine betaine
EPB54_RS09165	COG1022	Amp-dependent synthetase and ligase
EPB54_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS09185	COG0745	RESPONSE REGULATOR receiver
EPB54_RS09190	COG0642	Histidine kinase
EPB54_RS09195	COG1368	sulfuric ester hydrolase activity
EPB54_RS09220	COG1115	amino acid carrier protein
EPB54_RS09230	COG1280	lysine exporter protein (LysE YggA)
EPB54_RS09235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPB54_RS09240	COG1560	Kdo2-lipid A biosynthetic process
EPB54_RS09250	COG0531	amino acid
EPB54_RS09265	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EPB54_RS09270	COG3063	Type IV pilus biogenesis stability protein PilW
EPB54_RS09285	COG3850	Histidine kinase
EPB54_RS09285	COG4999	Histidine kinase
EPB54_RS09285	COG3437	response regulator, receiver
EPB54_RS09285	COG2205	protein histidine kinase activity
EPB54_RS09300	COG0110	maltose O-acetyltransferase activity
EPB54_RS09320	COG2315	Protein conserved in bacteria
EPB54_RS09325	COG1846	Transcriptional regulator
EPB54_RS09345	COG2200	EAL domain
EPB54_RS09355	COG1227	inorganic diphosphatase activity
EPB54_RS09360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB54_RS09365	COG1012	belongs to the aldehyde dehydrogenase family
EPB54_RS09370	COG2957	Belongs to the agmatine deiminase family
EPB54_RS09380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB54_RS09385	COG1012	belongs to the aldehyde dehydrogenase family
EPB54_RS09390	COG1917	Cupin 2, conserved barrel domain protein
EPB54_RS09390	COG1396	sequence-specific DNA binding
EPB54_RS09395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EPB54_RS09405	COG0174	glutamine synthetase
EPB54_RS09410	COG1757	Na H antiporter
EPB54_RS09475	COG4115	mRNA cleavage
EPB54_RS09480	COG2161	toxin-antitoxin pair type II binding
EPB54_RS09640	COG4735	regulation of single-species biofilm formation
EPB54_RS09650	COG2732	(Barnase) inhibitor
EPB54_RS09750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB54_RS09775	COG4735	regulation of single-species biofilm formation
EPB54_RS09790	COG1051	belongs to the nudix hydrolase family
EPB54_RS10070	COG1683	Conserved Protein
EPB54_RS10155	COG0519	Catalyzes the synthesis of GMP from XMP
EPB54_RS10220	COG0653	protein targeting
EPB54_RS10245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB54_RS10390	COG4628	conserved protein (DUF2132)
EPB54_RS10500	COG1444	tRNA N-acetyltransferase activity
EPB54_RS10585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB54_RS10595	COG3768	UPF0283 membrane protein
EPB54_RS10600	COG3106	COG3106 Predicted ATPase
EPB54_RS10620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB54_RS10625	COG2205	protein histidine kinase activity
EPB54_RS10625	COG0784	Response regulator, receiver
EPB54_RS10635	COG0494	nUDIX hydrolase
EPB54_RS10640	COG0814	amino acid
EPB54_RS10645	COG1760	l-serine dehydratase
EPB54_RS10650	COG2200	EAL domain
EPB54_RS10660	COG0720	synthase
EPB54_RS10680	COG2801	Transposase and inactivated derivatives
EPB54_RS10690	COG1278	Cold shock
EPB54_RS10695	COG0557	exoribonuclease II activity
EPB54_RS10715	COG0017	Asparaginyl-tRNA synthetase
EPB54_RS10725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB54_RS10750	COG1448	Aminotransferase
EPB54_RS10770	COG0840	transmembrane signaling receptor activity
EPB54_RS10775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB54_RS10780	COG1846	Transcriptional regulator
EPB54_RS10805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EPB54_RS10820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB54_RS10825	COG3108	Peptidase M15
EPB54_RS10830	COG2989	Protein conserved in bacteria
EPB54_RS10855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB54_RS10865	COG4235	cytochrome complex assembly
EPB54_RS10865	COG3088	subunit of a heme lyase
EPB54_RS10875	COG1138	Cytochrome C-type biogenesis protein
EPB54_RS10880	COG3301	Polysulphide reductase, NrfD
EPB54_RS10885	COG0437	4 iron, 4 sulfur cluster binding
EPB54_RS10895	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EPB54_RS10915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB54_RS10920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB54_RS10925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB54_RS10950	COG0019	diaminopimelate decarboxylase activity
EPB54_RS10990	COG0322	excinuclease ABC activity
EPB54_RS10995	COG2197	response regulator
EPB54_RS11000	COG0417	DNA replication proofreading
EPB54_RS11010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPB54_RS11015	COG3099	Belongs to the UPF0263 family
EPB54_RS11025	COG1187	pseudouridine synthase activity
EPB54_RS11035	COG0009	L-threonylcarbamoyladenylate synthase
EPB54_RS11040	COG0613	PHP domain protein
EPB54_RS11050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB54_RS11055	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB54_RS11060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPB54_RS11065	COG0135	phosphoribosylanthranilate isomerase activity
EPB54_RS11065	COG0134	indole-3-glycerol-phosphate synthase activity
EPB54_RS11070	COG0133	tryptophan synthase activity
EPB54_RS11075	COG0159	tryptophan synthase activity
EPB54_RS11085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB54_RS11090	COG0318	PFAM AMP-dependent synthetase and ligase
EPB54_RS11100	COG1301	dicarboxylic acid transport
EPB54_RS11120	COG2917	probably involved in intracellular septation
EPB54_RS11130	COG2350	Protein conserved in bacteria
EPB54_RS11140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPB54_RS11150	COG0583	DNA-binding transcription factor activity
EPB54_RS11165	COG3706	GGDEF domain
EPB54_RS11165	COG5001	Diguanylate cyclase
EPB54_RS11165	COG4251	negative regulation of phosphorylation
EPB54_RS11165	COG2203	Gaf domain
EPB54_RS11170	COG1032	radical SAM domain protein
EPB54_RS11175	COG0840	transmembrane signaling receptor activity
EPB54_RS11185	COG0745	RESPONSE REGULATOR receiver
EPB54_RS11190	COG3850	Histidine kinase
EPB54_RS11190	COG5002	protein histidine kinase activity
EPB54_RS11240	COG1335	isochorismatase
EPB54_RS11245	COG0577	efflux transmembrane transporter activity
EPB54_RS11245	COG1136	(ABC) transporter
EPB54_RS11255	COG1136	(ABC) transporter
EPB54_RS11255	COG0577	efflux transmembrane transporter activity
EPB54_RS11265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB54_RS11295	COG3118	belongs to the thioredoxin family
EPB54_RS11300	COG4232	protein-disulfide reductase activity
EPB54_RS11340	COG2863	cytochrome
EPB54_RS11345	COG3258	Cytochrome c
EPB54_RS11350	COG2995	paraquat-inducible protein a
EPB54_RS11355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB54_RS11355	COG3008	intermembrane lipid transfer
EPB54_RS11365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPB54_RS11390	COG4166	transmembrane transport
EPB54_RS11395	COG0284	orotidine-5'-phosphate decarboxylase activity
EPB54_RS11400	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EPB54_RS11405	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EPB54_RS11415	COG0539	negative regulation of cytoplasmic translation
EPB54_RS11420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPB54_RS11425	COG0616	signal peptide processing
EPB54_RS11430	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS11445	COG0587	DNA-directed DNA polymerase activity
EPB54_RS11450	COG0784	Response regulator, receiver
EPB54_RS11450	COG0835	chemotaxis
EPB54_RS11455	COG1940	carbohydrate kinase activity
EPB54_RS11460	COG0469	pyruvate kinase activity
EPB54_RS11465	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB54_RS11480	COG0733	neurotransmitter:sodium symporter activity
EPB54_RS11500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB54_RS11500	COG1263	PTS System
EPB54_RS11505	COG0084	hydrolase, TatD family'
EPB54_RS11515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPB54_RS11520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPB54_RS11550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB54_RS11555	COG0416	fatty acid biosynthetic process
EPB54_RS11565	COG1399	metal-binding, possibly nucleic acid-binding protein
EPB54_RS11570	COG0424	maF-like protein
EPB54_RS11575	COG0564	pseudouridine synthase activity
EPB54_RS11580	COG1530	ribonuclease E activity
EPB54_RS11585	COG0659	secondary active sulfate transmembrane transporter activity
EPB54_RS11590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPB54_RS11595	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EPB54_RS11605	COG0572	uridine kinase
EPB54_RS11610	COG0489	protein tyrosine kinase activity
EPB54_RS11615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB54_RS11615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB54_RS11625	COG2186	Transcriptional regulator
EPB54_RS11630	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB54_RS11635	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EPB54_RS11640	COG3318	Belongs to the UPF0149 family
EPB54_RS11640	COG3012	SEC-C Motif Domain Protein
EPB54_RS11645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB54_RS11655	COG0366	Alpha amylase catalytic
EPB54_RS11660	COG1122	ATPase activity
EPB54_RS11665	COG4120	Belongs to the binding-protein-dependent transport system permease family
EPB54_RS11675	COG3092	negative regulation of chromosome organization
EPB54_RS11680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB54_RS11685	COG0280	phosphate acetyltransferase
EPB54_RS11685	COG0857	belongs to the CobB CobQ family
EPB54_RS11690	COG3174	membrane
EPB54_RS11700	COG0435	Glutathione S-transferase
EPB54_RS11710	COG0444	Belongs to the ABC transporter superfamily
EPB54_RS11715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB54_RS11720	COG0601	transmembrane transport
EPB54_RS11730	COG0314	molybdopterin synthase activity
EPB54_RS11735	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EPB54_RS11740	COG0315	cyclic pyranopterin monophosphate synthase activity
EPB54_RS11745	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPB54_RS11750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPB54_RS11755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EPB54_RS11760	COG2198	Histidine kinase
EPB54_RS11765	COG2204	response regulator
EPB54_RS11770	COG0556	nucleotide-excision repair
EPB54_RS11785	COG4657	Part of a membrane complex involved in electron transport
EPB54_RS11790	COG2878	Part of a membrane complex involved in electron transport
EPB54_RS11795	COG4656	Part of a membrane complex involved in electron transport
EPB54_RS11800	COG4658	electron transport chain
EPB54_RS11805	COG4659	FMN binding
EPB54_RS11810	COG4660	Part of a membrane complex involved in electron transport
EPB54_RS11815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPB54_RS11820	COG0346	lactoylglutathione lyase activity
EPB54_RS11830	COG2885	chlorophyll binding
EPB54_RS11845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPB54_RS11850	COG2056	Na+-H+ antiporter family
EPB54_RS11860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPB54_RS11880	COG1012	belongs to the aldehyde dehydrogenase family
EPB54_RS11880	COG1454	alcohol dehydrogenase
EPB54_RS11885	COG2095	MarC family integral membrane protein
EPB54_RS11890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB54_RS11895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB54_RS11900	COG1757	Na H antiporter
EPB54_RS11915	COG3081	Nucleoid-associated protein
EPB54_RS11920	COG3082	Protein of unknown function (DUF1414)
EPB54_RS11925	COG3083	sulfuric ester hydrolase activity
EPB54_RS11935	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPB54_RS11955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB54_RS11960	COG0778	Nitroreductase
EPB54_RS11965	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB54_RS11965	COG1902	pentaerythritol trinitrate reductase activity
EPB54_RS11970	COG0616	signal peptide processing
EPB54_RS11975	COG0252	asparaginase activity
EPB54_RS11980	COG3139	Protein of unknown function (DUF1315)
EPB54_RS11990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB54_RS11995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB54_RS12010	COG2226	methyltransferase
EPB54_RS12030	COG1785	Belongs to the alkaline phosphatase family
EPB54_RS12040	COG0346	lactoylglutathione lyase activity
EPB54_RS12045	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPB54_RS12050	COG0668	transmembrane transport
EPB54_RS12055	COG2983	Belongs to the UPF0260 family
EPB54_RS12060	COG2261	transglycosylase associated protein
EPB54_RS12075	COG3681	Belongs to the UPF0597 family
EPB54_RS12080	COG0251	oxidation-reduction process
EPB54_RS12085	COG0814	amino acid
EPB54_RS12090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB54_RS12095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPB54_RS12100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EPB54_RS12110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPB54_RS12115	COG2832	Protein of unknown function (DUF454)
EPB54_RS12125	COG0745	RESPONSE REGULATOR receiver
EPB54_RS12130	COG0583	DNA-binding transcription factor activity
EPB54_RS12135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPB54_RS12140	COG1286	toxin biosynthetic process
EPB54_RS12145	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EPB54_RS12150	COG0285	dihydrofolate synthase activity
EPB54_RS12155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPB54_RS12160	COG0101	tRNA pseudouridine synthase activity
EPB54_RS12170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB54_RS12175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB54_RS12180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB54_RS12185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EPB54_RS12185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB54_RS12190	COG0431	NADPH-dependent FMN reductase
EPB54_RS12205	COG3101	peptidyl-lysine hydroxylation
EPB54_RS12215	COG2860	membrane
EPB54_RS12220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPB54_RS12225	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB54_RS12230	COG2840	Smr protein MutS2
EPB54_RS12235	COG2062	phosphohistidine phosphatase, SixA
EPB54_RS12250	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPB54_RS12250	COG1024	Enoyl-CoA hydratase
EPB54_RS12255	COG0183	Belongs to the thiolase family
EPB54_RS12270	COG2067	long-chain fatty acid transport protein
EPB54_RS12280	COG2853	Lipoprotein
EPB54_RS12295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPB54_RS12300	COG1138	Cytochrome C-type biogenesis protein
EPB54_RS12305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EPB54_RS12310	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB54_RS12315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB54_RS12320	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB54_RS12325	COG4133	protoheme IX ABC transporter activity
EPB54_RS12335	COG0835	chemotaxis
EPB54_RS12345	COG1192	Involved in chromosome partitioning
EPB54_RS12350	COG2201	protein-glutamate methylesterase activity
EPB54_RS12355	COG0643	Histidine kinase
EPB54_RS12355	COG0784	Response regulator, receiver
EPB54_RS12355	COG2198	Histidine kinase
EPB54_RS12360	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EPB54_RS12400	COG1987	bacterial-type flagellum assembly
EPB54_RS12450	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPB54_RS12460	COG1677	Flagellar hook-basal body complex protein FliE
EPB54_RS12480	COG1516	flagellar protein fliS
EPB54_RS12490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB54_RS12495	COG1334	flagellar protein FlaG
EPB54_RS12500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS12505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS12515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS12520	COG2837	iron assimilation
EPB54_RS12550	COG1393	Belongs to the ArsC family
EPB54_RS12555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB54_RS12570	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EPB54_RS12575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPB54_RS12580	COG2716	regulation of RNA biosynthetic process
EPB54_RS12610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPB54_RS12675	COG0804	urea catabolic process
EPB54_RS12695	COG0747	negative chemotaxis
EPB54_RS12705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB54_RS12720	COG2207	Transcriptional regulator
EPB54_RS12735	COG2916	Histone family protein nucleoid-structuring protein H-NS
EPB54_RS12825	COG4790	Type iii secretion
EPB54_RS12835	COG3710	Transcriptional regulator
EPB54_RS12865	COG4792	protein secretion
EPB54_RS12870	COG4789	Type iii secretion
EPB54_RS12980	COG2199	diguanylate cyclase activity
EPB54_RS12980	COG2200	EAL domain
EPB54_RS12980	COG2202	Pas domain
EPB54_RS12995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPB54_RS13010	COG4783	chaperone-mediated protein folding
EPB54_RS13015	COG1393	Belongs to the ArsC family
EPB54_RS13035	COG2233	PERMEase
EPB54_RS13040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPB54_RS13045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EPB54_RS13050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPB54_RS13055	COG0121	glutamine amidotransferase
EPB54_RS13060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB54_RS13065	COG1960	acyl-CoA dehydrogenase activity
EPB54_RS13080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPB54_RS13085	COG0328	RNA-DNA hybrid ribonuclease activity
EPB54_RS13090	COG2226	methyltransferase
EPB54_RS13095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB54_RS13100	COG0741	lytic transglycosylase activity
EPB54_RS13100	COG1388	LysM domain
EPB54_RS13110	COG3021	interspecies interaction between organisms
EPB54_RS13115	COG0347	Belongs to the P(II) protein family
EPB54_RS13125	COG0037	tRNA processing
EPB54_RS13130	COG0825	malonyl-CoA metabolic process
EPB54_RS13135	COG0587	DNA-directed DNA polymerase activity
EPB54_RS13145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB54_RS13150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB54_RS13155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB54_RS13160	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EPB54_RS13170	COG0750	zinc metalloprotease
EPB54_RS13175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPB54_RS13180	COG0575	Belongs to the CDS family
EPB54_RS13185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPB54_RS13190	COG0233	cytoplasmic translational termination
EPB54_RS13195	COG0528	UMP kinase activity
EPB54_RS13200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPB54_RS13205	COG0052	Belongs to the universal ribosomal protein uS2 family
EPB54_RS13210	COG0024	Methionine aminopeptidase
EPB54_RS13215	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EPB54_RS13225	COG0564	pseudouridine synthase activity
EPB54_RS13230	COG3098	single-species biofilm formation
EPB54_RS13255	COG1671	Belongs to the UPF0178 family
EPB54_RS13260	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB54_RS13275	COG0254	rRNA binding
EPB54_RS13280	COG1720	tRNA m6t6A37 methyltransferase activity
EPB54_RS13285	COG0442	prolyl-tRNA aminoacylation
EPB54_RS13305	COG0733	neurotransmitter:sodium symporter activity
EPB54_RS13320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB54_RS13325	COG0514	ATP-dependent DNA helicase (RecQ)
EPB54_RS13330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPB54_RS13345	COG1477	protein flavinylation
EPB54_RS13350	COG2871	sodium ion transport
EPB54_RS13355	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB54_RS13360	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB54_RS13365	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB54_RS13370	COG1805	sodium ion transport
EPB54_RS13375	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB54_RS13380	COG0271	Belongs to the BolA IbaG family
EPB54_RS13385	COG2813	Specifically methylates the guanine in position
EPB54_RS13390	COG3056	Lipoprotein
EPB54_RS13410	COG1595	DNA-templated transcription, initiation
EPB54_RS13435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EPB54_RS13440	COG0693	protein deglycase activity
EPB54_RS13445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPB54_RS13450	COG3706	GGDEF domain
EPB54_RS13455	COG2166	iron-sulfur cluster assembly
EPB54_RS13460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPB54_RS13465	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EPB54_RS13475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB54_RS13475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB54_RS13485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB54_RS13490	COG1074	ATP-dependent DNA helicase activity
EPB54_RS13495	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EPB54_RS13515	COG3141	response to X-ray
EPB54_RS13520	COG2171	N-acyltransferase activity
EPB54_RS13525	COG0584	glycerophosphoryl diester phosphodiesterase
EPB54_RS13530	COG2271	Major facilitator Superfamily
EPB54_RS13545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB54_RS13550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPB54_RS13555	COG1349	DNA-binding transcription factor activity
EPB54_RS13560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPB54_RS13565	COG0598	Magnesium transport protein CorA
EPB54_RS13580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB54_RS13585	COG1609	Transcriptional regulator
EPB54_RS13590	COG2211	Major facilitator Superfamily
EPB54_RS13605	COG2017	converts alpha-aldose to the beta-anomer
EPB54_RS13610	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EPB54_RS13620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPB54_RS13630	COG1609	Transcriptional regulator
EPB54_RS13635	COG3250	beta-galactosidase activity
EPB54_RS13640	COG2731	YhcH YjgK YiaL family protein
EPB54_RS13645	COG0531	amino acid
EPB54_RS13650	COG0583	DNA-binding transcription factor activity
EPB54_RS13710	COG4964	Belongs to the GSP D family
EPB54_RS13735	COG2169	Transcriptional regulator
EPB54_RS13740	COG1022	Amp-dependent synthetase and ligase
EPB54_RS13750	COG0583	DNA-binding transcription factor activity
EPB54_RS13755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB54_RS13760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPB54_RS13770	COG0560	Phosphoserine phosphatase
EPB54_RS13780	COG0813	purine-nucleoside phosphorylase activity
EPB54_RS13785	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EPB54_RS13790	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EPB54_RS13795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EPB54_RS13800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB54_RS13805	COG0084	hydrolase, TatD family'
EPB54_RS13815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EPB54_RS13835	COG3153	acetyltransferase
EPB54_RS13840	COG3154	lipid carrier protein
EPB54_RS13850	COG0826	peptidase U32
EPB54_RS13855	COG0826	peptidase U32
EPB54_RS13860	COG0534	Mate efflux family protein
EPB54_RS13875	COG1185	polyribonucleotide nucleotidyltransferase activity
EPB54_RS13880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPB54_RS13885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPB54_RS13890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPB54_RS13895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPB54_RS13900	COG0195	Participates in both transcription termination and antitermination
EPB54_RS13905	COG0779	Required for maturation of 30S ribosomal subunits
EPB54_RS13920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB54_RS13930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB54_RS13935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPB54_RS13940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPB54_RS13945	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EPB54_RS13950	COG1534	Rna-binding protein
EPB54_RS13955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB54_RS13960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB54_RS13965	COG2027	D-alanyl-D-alanine carboxypeptidase
EPB54_RS13975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB54_RS13980	COG0739	heme binding
EPB54_RS13985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB54_RS13995	COG0316	Belongs to the HesB IscA family
EPB54_RS14000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPB54_RS14005	COG0628	permease
EPB54_RS14010	COG2813	Specifically methylates the guanine in position
EPB54_RS14015	COG0784	Response regulator, receiver
EPB54_RS14015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB54_RS14015	COG2198	Histidine kinase
EPB54_RS14015	COG2205	protein histidine kinase activity
EPB54_RS14020	COG0747	negative chemotaxis
EPB54_RS14030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB54_RS14035	COG0444	Belongs to the ABC transporter superfamily
EPB54_RS14040	COG4608	Belongs to the ABC transporter superfamily
EPB54_RS14050	COG2971	BadF BadG BcrA BcrD
EPB54_RS14065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB54_RS14070	COG3842	ATPase activity
EPB54_RS14080	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB54_RS14085	COG0004	ammonium transporteR
EPB54_RS14095	COG3112	Uncharacterised protein family (UPF0231)
EPB54_RS14100	COG1049	propionate catabolic process, 2-methylcitrate cycle
EPB54_RS14105	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPB54_RS14110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB54_RS14115	COG1643	Atp-dependent helicase
EPB54_RS14120	COG1489	DNA binding
EPB54_RS14135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB54_RS14150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB54_RS14155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPB54_RS14160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPB54_RS14170	COG0842	Transport permease protein
EPB54_RS14175	COG1131	(ABC) transporter
EPB54_RS14185	COG0659	secondary active sulfate transmembrane transporter activity
EPB54_RS14190	COG0288	reversible hydration of carbon dioxide
EPB54_RS14205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB54_RS14210	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB54_RS14215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EPB54_RS14220	COG2186	Transcriptional regulator
EPB54_RS14230	COG0157	Belongs to the NadC ModD family
EPB54_RS14240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB54_RS14245	COG1459	type II secretion system
EPB54_RS14255	COG0237	dephospho-CoA kinase activity
EPB54_RS14260	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EPB54_RS14265	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EPB54_RS14270	COG0335	large ribosomal subunit rRNA binding
EPB54_RS14275	COG0336	Belongs to the RNA methyltransferase TrmD family
EPB54_RS14280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPB54_RS14285	COG0228	four-way junction DNA binding
EPB54_RS14290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPB54_RS14295	COG4137	Cytochrome C assembly protein
EPB54_RS14300	COG4536	flavin adenine dinucleotide binding
EPB54_RS14305	COG1854	S-ribosylhomocysteine lyase activity
EPB54_RS14315	COG2918	glutathione biosynthetic process
EPB54_RS14320	COG0612	Peptidase, M16
EPB54_RS14325	COG1238	metal cluster binding
EPB54_RS14335	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPB54_RS14340	COG5016	pyruvate
EPB54_RS14340	COG0511	ligase activity, forming carbon-carbon bonds
EPB54_RS14345	COG3630	sodium ion export across plasma membrane
EPB54_RS14405	COG0527	aspartate kinase activity
EPB54_RS14410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPB54_RS14415	COG2137	regulation of response to DNA damage stimulus
EPB54_RS14420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPB54_RS14425	COG1546	Belongs to the CinA family
EPB54_RS14430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPB54_RS14445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPB54_RS14450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPB54_RS14455	COG0585	pseudouridine synthase activity
EPB54_RS14460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EPB54_RS14465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPB54_RS14470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EPB54_RS14475	COG0148	phosphopyruvate hydratase activity
EPB54_RS14480	COG0504	CTP synthase activity
EPB54_RS14485	COG3956	TIGRFAM MazG family protein
EPB54_RS14490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB54_RS14500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB54_RS14510	COG0736	holo-[acyl-carrier-protein] synthase activity
EPB54_RS14515	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPB54_RS14520	COG1381	Involved in DNA repair and RecF pathway recombination
EPB54_RS14525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPB54_RS14530	COG0571	ribonuclease III activity
EPB54_RS14540	COG0481	GTPase activity
EPB54_RS14545	COG3086	response to oxidative stress
EPB54_RS14555	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
EPB54_RS14560	COG1595	DNA-templated transcription, initiation
EPB54_RS14570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPB54_RS14580	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EPB54_RS14585	COG0354	folic acid binding
EPB54_RS14600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB54_RS14605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB54_RS14610	COG3079	Belongs to the UPF0149 family
EPB54_RS14620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EPB54_RS14630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPB54_RS14635	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EPB54_RS14640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB54_RS14650	COG0583	DNA-binding transcription factor activity
EPB54_RS14660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPB54_RS14665	COG0668	transmembrane transport
EPB54_RS14670	COG0191	fructose-bisphosphate aldolase activity
EPB54_RS14675	COG0126	phosphoglycerate kinase activity
EPB54_RS14680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB54_RS14685	COG4771	TonB-dependent receptor
EPB54_RS14690	COG0583	DNA-binding transcription factor activity
EPB54_RS14695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB54_RS14705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPB54_RS14715	COG3091	SprT-like family
EPB54_RS14720	COG2356	endonuclease I
EPB54_RS14725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPB54_RS14730	COG0189	ligase activity
EPB54_RS14735	COG1678	Uncharacterized ACR, COG1678
EPB54_RS14740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPB54_RS14755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPB54_RS14760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EPB54_RS14765	COG0762	integral membrane protein
EPB54_RS14770	COG1872	DUF167
EPB54_RS14780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPB54_RS14785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPB54_RS14790	COG2066	Belongs to the glutaminase family
EPB54_RS14800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPB54_RS14810	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EPB54_RS14815	COG0741	lytic transglycosylase activity
EPB54_RS14885	COG1012	belongs to the aldehyde dehydrogenase family
EPB54_RS14935	COG3437	response regulator, receiver
EPB54_RS14945	COG3394	polysaccharide catabolic process
EPB54_RS14950	COG1486	melibiose metabolic process
EPB54_RS14955	COG1447	Phosphotransferase system cellobiose-specific component IIA
EPB54_RS14960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPB54_RS14965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPB54_RS14970	COG0726	polysaccharide deacetylase
EPB54_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS14995	COG0795	lipopolysaccharide-transporting ATPase activity
EPB54_RS15000	COG0795	lipopolysaccharide-transporting ATPase activity
EPB54_RS15005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB54_RS15010	COG2927	DNA polymerase III (CHI subunit)
EPB54_RS15015	COG0525	valine-tRNA ligase activity
EPB54_RS15120	COG2235	arginine
EPB54_RS15125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPB54_RS15135	COG0540	Belongs to the ATCase OTCase family
EPB54_RS15140	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EPB54_RS15145	COG0251	oxidation-reduction process
EPB54_RS15150	COG0204	Acyl-transferase
EPB54_RS15155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPB54_RS15160	COG5007	Belongs to the BolA IbaG family
EPB54_RS15170	COG2854	intermembrane phospholipid transfer
EPB54_RS15175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB54_RS15180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPB54_RS15185	COG1127	ABC transporter
EPB54_RS15195	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPB54_RS15195	COG0517	IMP dehydrogenase activity
EPB54_RS15205	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPB54_RS15210	COG1137	ATPase activity
EPB54_RS15220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB54_RS15225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB54_RS15230	COG1660	Displays ATPase and GTPase activities
EPB54_RS15235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB54_RS15240	COG2239	Acts as a magnesium transporter
EPB54_RS15245	COG0312	modulator of DNA gyrase
EPB54_RS15250	COG3028	Belongs to the UPF0307 family
EPB54_RS15255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB54_RS15260	COG0564	pseudouridine synthase activity
EPB54_RS15275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPB54_RS15280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EPB54_RS15285	COG0312	modulator of DNA gyrase
EPB54_RS15290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB54_RS15295	COG3164	Protein of unknown function
EPB54_RS15305	COG0424	maF-like protein
EPB54_RS15310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPB54_RS15315	COG1792	Involved in formation and maintenance of cell shape
EPB54_RS15320	COG1077	Cell shape determining protein MreB Mrl
EPB54_RS15355	COG2165	general secretion pathway protein
EPB54_RS15365	COG1459	type II secretion system
EPB54_RS15370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB54_RS15380	COG3267	Type II secretory pathway component ExeA
EPB54_RS15380	COG3409	Peptidoglycan-binding domain 1 protein
EPB54_RS15405	COG2199	diguanylate cyclase activity
EPB54_RS15405	COG2200	EAL domain
EPB54_RS15410	COG0629	single-stranded DNA binding
EPB54_RS15425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPB54_RS15435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPB54_RS15440	COG0527	aspartate kinase activity
EPB54_RS15445	COG1410	methionine synthase
EPB54_RS15445	COG0646	methionine synthase
EPB54_RS15460	COG3335	DDE superfamily endonuclease
EPB54_RS15515	COG0175	sulfate reduction
EPB54_RS15520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB54_RS15525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB54_RS15550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB54_RS15560	COG0735	belongs to the Fur family
EPB54_RS15570	COG0166	Belongs to the GPI family
EPB54_RS15575	COG0432	Pfam Uncharacterised protein family UPF0047
EPB54_RS15585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB54_RS15600	COG0359	binds to the 23S rRNA
EPB54_RS15610	COG2965	DNA replication, synthesis of RNA primer
EPB54_RS15615	COG0360	Binds together with S18 to 16S ribosomal RNA
EPB54_RS15620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPB54_RS15625	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EPB54_RS15635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPB54_RS15640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPB54_RS15670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPB54_RS15680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB54_RS15680	COG0678	peroxiredoxin activity
EPB54_RS15695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB54_RS15695	COG0165	Argininosuccinate lyase
EPB54_RS15700	COG0137	argininosuccinate synthase activity
EPB54_RS15705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB54_RS15710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPB54_RS15715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB54_RS15720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EPB54_RS15730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPB54_RS15735	COG0460	homoserine dehydrogenase
EPB54_RS15735	COG0527	aspartate kinase activity
EPB54_RS15740	COG0626	cystathionine gamma-synthase activity
EPB54_RS15750	COG0281	malic enzyme
EPB54_RS15760	COG2906	2 iron, 2 sulfur cluster binding
EPB54_RS15765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPB54_RS15770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB54_RS15775	COG0049	tRNA binding
EPB54_RS15790	COG2923	Belongs to the DsrF TusC family
EPB54_RS15795	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EPB54_RS15800	COG2964	Protein conserved in bacteria
EPB54_RS15805	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB54_RS15815	COG2900	Belongs to the SlyX family
EPB54_RS15820	COG1446	asparaginase
EPB54_RS15830	COG1047	Peptidyl-prolyl cis-trans
EPB54_RS15845	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB54_RS15855	COG0488	(ABC) transporter
EPB54_RS15865	COG0429	hydrolase of the alpha beta-hydrolase fold
EPB54_RS15870	COG3089	Belongs to the UPF0270 family
EPB54_RS15875	COG3954	Phosphoribulokinase
EPB54_RS15880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB54_RS15890	COG1012	belongs to the aldehyde dehydrogenase family
EPB54_RS15900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPB54_RS15905	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB54_RS15935	COG0180	Tryptophanyl-tRNA synthetase
EPB54_RS15940	COG0546	phosphoglycolate phosphatase activity
EPB54_RS15945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB54_RS15950	COG0557	exoribonuclease II activity
EPB54_RS15955	COG1959	2 iron, 2 sulfur cluster binding
EPB54_RS15960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB54_RS15960	COG1017	nitric oxide dioxygenase activity
EPB54_RS15965	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EPB54_RS15975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB54_RS15980	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EPB54_RS15985	COG0330	HflC and HflK could
EPB54_RS15990	COG0330	HflC and HflK could
EPB54_RS15995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPB54_RS16005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPB54_RS16010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPB54_RS16020	COG0802	atpase or kinase
EPB54_RS16025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPB54_RS16095	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EPB54_RS16100	COG1162	GTPase activity
EPB54_RS16105	COG0688	phosphatidylethanolamine metabolic process
EPB54_RS16110	COG0471	metal ion transport
EPB54_RS16125	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPB54_RS16130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB54_RS16135	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EPB54_RS16140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPB54_RS16145	COG1045	serine acetyltransferase
EPB54_RS16150	COG4942	peptidase
EPB54_RS16170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EPB54_RS16180	COG1053	succinate dehydrogenase
EPB54_RS16185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB54_RS16190	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EPB54_RS16195	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EPB54_RS16205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPB54_RS16210	COG1509	lysine 2,3-aminomutase activity
EPB54_RS16220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB54_RS16235	COG0459	protein refolding
EPB54_RS16245	COG0534	Mate efflux family protein
EPB54_RS16250	COG0205	6-phosphofructokinase activity
EPB54_RS16260	COG3678	ATP-independent chaperone mediated protein folding
EPB54_RS16265	COG0745	RESPONSE REGULATOR receiver
EPB54_RS16270	COG2205	protein histidine kinase activity
EPB54_RS16280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPB54_RS16285	COG3030	protein affecting phage T7 exclusion by the F plasmid
EPB54_RS16290	COG1027	Aspartate ammonia-lyase
EPB54_RS16295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB54_RS16300	COG4232	protein-disulfide reductase activity
EPB54_RS16310	COG3263	regulation of cellular component size
EPB54_RS16320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB54_RS16345	COG2198	Histidine kinase
EPB54_RS16345	COG2205	protein histidine kinase activity
EPB54_RS16345	COG0784	Response regulator, receiver
EPB54_RS16350	COG2814	Major facilitator Superfamily
EPB54_RS16365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB54_RS16370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPB54_RS16375	COG0511	ligase activity, forming carbon-carbon bonds
EPB54_RS16380	COG0439	Biotin carboxylase
EPB54_RS16390	COG2264	protein methyltransferase activity
EPB54_RS16395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB54_RS16400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EPB54_RS16405	COG2814	Major facilitator Superfamily
EPB54_RS16410	COG0488	(ABC) transporter
EPB54_RS16415	COG3706	GGDEF domain
EPB54_RS16480	COG1982	Orn Lys Arg decarboxylase major
EPB54_RS16485	COG0531	amino acid
EPB54_RS16495	COG3710	Transcriptional regulator
EPB54_RS16500	COG0789	Transcriptional regulator
EPB54_RS16510	COG0138	bifunctional purine biosynthesis protein purh
EPB54_RS16520	COG0151	Belongs to the GarS family
EPB54_RS16535	COG1253	flavin adenine dinucleotide binding
EPB54_RS16545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB54_RS16550	COG1573	uracil-dna glycosylase
EPB54_RS16555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPB54_RS16570	COG2816	NAD+ diphosphatase activity
EPB54_RS16575	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EPB54_RS16580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EPB54_RS16585	COG0085	RNA polymerase activity
EPB54_RS16590	COG0222	ribosome binding
EPB54_RS16595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPB54_RS16600	COG0081	regulation of translation
EPB54_RS16605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EPB54_RS16610	COG0250	Participates in transcription elongation, termination and antitermination
EPB54_RS16615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB54_RS16625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPB54_RS16660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPB54_RS16670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB54_RS16725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPB54_RS16735	COG4206	TonB-dependent receptor
EPB54_RS16740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB54_RS16755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB54_RS16760	COG0534	Mate efflux family protein
EPB54_RS16765	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EPB54_RS16770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPB54_RS16780	COG2937	Belongs to the GPAT DAPAT family
EPB54_RS16785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPB54_RS16790	COG3161	chorismate lyase activity
EPB54_RS16795	COG1580	Controls the rotational direction of flagella during chemotaxis
EPB54_RS16800	COG0705	Rhomboid family
EPB54_RS16805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB54_RS16815	COG2177	Part of the ABC transporter FtsEX involved in
EPB54_RS16820	COG2884	Cell division ATP-binding protein ftsE
EPB54_RS16825	COG0552	protein localization to endoplasmic reticulum
EPB54_RS16830	COG0742	ribosomal rna small subunit methyltransferase
EPB54_RS16840	COG2095	MarC family integral membrane protein
EPB54_RS16895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB54_RS16900	COG0640	Transcriptional regulator
EPB54_RS16905	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB54_RS16910	COG1280	lysine exporter protein (LysE YggA)
EPB54_RS16915	COG2267	carboxylic ester hydrolase activity
EPB54_RS16920	COG0561	phosphatase activity
EPB54_RS16935	COG3148	PFAM DTW domain containing protein
EPB54_RS16940	COG2199	diguanylate cyclase activity
EPB54_RS16940	COG3287	FIST C domain
EPB54_RS16940	COG2200	EAL domain
EPB54_RS16945	COG1011	Hydrolase
EPB54_RS16950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPB54_RS16960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EPB54_RS16965	COG0019	diaminopimelate decarboxylase activity
EPB54_RS16975	COG1965	Belongs to the frataxin family
EPB54_RS16980	COG3072	Adenylate cyclase
EPB54_RS16985	COG0181	hydroxymethylbilane synthase activity
EPB54_RS16990	COG1587	Uroporphyrinogen-III synthase
EPB54_RS16995	COG2959	enzyme of heme biosynthesis
EPB54_RS17000	COG3071	HemY protein
EPB54_RS17050	COG0633	Ferredoxin
EPB54_RS17055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EPB54_RS17075	COG3118	belongs to the thioredoxin family
EPB54_RS17080	COG0513	Belongs to the DEAD box helicase family
EPB54_RS17085	COG0248	Ppx GppA phosphatase
EPB54_RS17090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EPB54_RS17105	COG0514	ATP-dependent DNA helicase (RecQ)
EPB54_RS17110	COG2962	Rard protein
EPB54_RS17120	COG1280	lysine exporter protein (LysE YggA)
EPB54_RS17125	COG0405	Gamma-glutamyltransferase
EPB54_RS17135	COG0210	DNA helicase
EPB54_RS17145	COG3220	belongs to the UPF0276 family
EPB54_RS17175	COG0006	proline dipeptidase activity
EPB54_RS17175	COG0006	proline dipeptidase activity
EPB54_RS17185	COG2022	thiamine diphosphate biosynthetic process
EPB54_RS17190	COG2104	thiamine diphosphate biosynthetic process
EPB54_RS17195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB54_RS17200	COG0352	thiamine-phosphate diphosphorylase activity
EPB54_RS17205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EPB54_RS17210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EPB54_RS17270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB54_RS17275	COG1739	Uncharacterized protein family UPF0029
EPB54_RS17280	COG1024	Enoyl-CoA hydratase
EPB54_RS17280	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPB54_RS17285	COG0183	Belongs to the thiolase family
EPB54_RS17290	COG0604	alcohol dehydrogenase
EPB54_RS17305	COG0425	Belongs to the sulfur carrier protein TusA family
EPB54_RS17315	COG2119	membrane
EPB54_RS17320	COG0752	glycyl-tRNA synthetase alpha subunit
EPB54_RS17325	COG0751	glycine-tRNA ligase activity
EPB54_RS17330	COG0366	Alpha amylase catalytic
EPB54_RS17335	COG3977	Valine--pyruvate aminotransferase
EPB54_RS17340	COG0071	Belongs to the small heat shock protein (HSP20) family
EPB54_RS17360	COG0187	DNA topoisomerase II activity
EPB54_RS17365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPB54_RS17370	COG0592	DNA-directed DNA polymerase activity
EPB54_RS17375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPB54_RS17400	COG1126	abc transporter atp-binding protein
EPB54_RS17420	COG0706	membrane insertase activity
EPB54_RS17425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EPB54_RS17430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB54_RS17435	COG0445	tRNA wobble uridine modification
EPB54_RS17440	COG0357	Ribosomal RNA small subunit methyltransferase G
EPB54_RS17445	COG1192	Involved in chromosome partitioning
EPB54_RS17450	COG1475	DNA binding
EPB54_RS17455	COG3312	ion transport
EPB54_RS17460	COG0356	it plays a direct role in the translocation of protons across the membrane
EPB54_RS17475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPB54_RS17480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPB54_RS17485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPB54_RS17490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPB54_RS17495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPB54_RS17500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EPB54_RS17505	COG0765	amino acid transport
EPB54_RS17510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB54_RS17515	COG2814	Major facilitator Superfamily
EPB54_RS17520	COG0583	DNA-binding transcription factor activity
EPB54_RS17530	COG0129	dihydroxy-acid dehydratase activity
EPB54_RS17535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPB54_RS17540	COG3978	acetolactate synthase activity
EPB54_RS17550	COG0606	chelatase, subunit chli
EPB54_RS17580	COG1278	Cold shock
EPB54_RS17600	COG0330	HflC and HflK could
EPB54_RS17610	COG1278	Cold shock
EPB54_RS17625	COG1278	Cold shock
EPB54_RS17635	COG1196	nuclear chromosome segregation
EPB54_RS17670	COG0204	Acyl-transferase
EPB54_RS17675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB54_RS17680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPB54_RS17690	COG3084	Protein conserved in bacteria
EPB54_RS17700	COG4326	sporulation control protein
EPB54_RS17705	COG1272	protein, Hemolysin III
EPB54_RS17715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB54_RS17720	COG0569	domain protein
EPB54_RS17725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPB54_RS17725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB54_RS17730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPB54_RS17735	COG0242	peptide deformylase activity
EPB54_RS17745	COG0758	DNA mediated transformation
EPB54_RS17750	COG2922	Belongs to the Smg family
EPB54_RS17755	COG0551	DNA topoisomerase type I activity
EPB54_RS17760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPB54_RS17765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPB54_RS17770	COG0009	L-threonylcarbamoyladenylate synthase
EPB54_RS17775	COG0408	coproporphyrinogen oxidase activity
EPB54_RS17780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPB54_RS17790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPB54_RS17830	COG0583	DNA-binding transcription factor activity
EPB54_RS17835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPB54_RS17840	COG2960	long-chain fatty acid transporting porin activity
EPB54_RS17850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB54_RS17855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB54_RS17920	COG4172	Belongs to the ABC transporter superfamily
EPB54_RS17925	COG0747	negative chemotaxis
EPB54_RS17930	COG0601	transmembrane transport
EPB54_RS17935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB54_RS17975	COG1609	Transcriptional regulator
EPB54_RS17980	COG0583	DNA-binding transcription factor activity
EPB54_RS17995	COG0129	dihydroxy-acid dehydratase activity
EPB54_RS18000	COG3265	gluconokinase activity
EPB54_RS18005	COG2610	gluconate transmembrane transporter activity
EPB54_RS18010	COG0800	Aldolase
EPB54_RS18015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EPB54_RS18020	COG0583	DNA-binding transcription factor activity
EPB54_RS18025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB54_RS18030	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPB54_RS18035	COG0339	signal peptide processing
EPB54_RS18040	COG1522	sequence-specific DNA binding
EPB54_RS18045	COG5002	protein histidine kinase activity
EPB54_RS18045	COG5001	Diguanylate cyclase
EPB54_RS18050	COG0742	ribosomal rna small subunit methyltransferase
EPB54_RS18065	COG0589	response to stress
EPB54_RS18070	COG1528	Iron-storage protein
EPB54_RS18080	COG2081	HI0933 family
EPB54_RS18110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EPB54_RS18225	COG3423	Transcriptional regulator
EPB54_RS18315	COG0346	lactoylglutathione lyase activity
EPB54_RS18335	COG2239	Acts as a magnesium transporter
EPB54_RS18370	COG0242	peptide deformylase activity
EPB54_RS18420	COG2176	DNA-directed DNA polymerase activity
EPB54_RS18425	COG0583	DNA-binding transcription factor activity
EPB54_RS18430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPB54_RS18435	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EPB54_RS18460	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPB54_RS18460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPB54_RS18465	COG0509	glycine decarboxylation via glycine cleavage system
EPB54_RS18470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB54_RS18510	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPB54_RS18510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB54_RS18510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB54_RS18515	COG1105	Belongs to the carbohydrate kinase PfkB family
EPB54_RS18520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB54_RS18520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB54_RS18525	COG1609	Transcriptional regulator
EPB54_RS18545	COG2203	Gaf domain
EPB54_RS18545	COG2200	EAL domain
EPB54_RS18545	COG2199	diguanylate cyclase activity
EPB54_RS18550	COG0765	amino acid transport
EPB54_RS18555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB54_RS18560	COG0765	amino acid transport
EPB54_RS18565	COG1126	abc transporter atp-binding protein
EPB54_RS18570	COG0469	pyruvate kinase activity
EPB54_RS18575	COG2271	Major facilitator Superfamily
EPB54_RS18600	COG1979	alcohol dehydrogenase
EPB54_RS18605	COG2207	Transcriptional regulator
EPB54_RS18620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB54_RS18625	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EPB54_RS18630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB54_RS18650	COG0784	Response regulator, receiver
EPB54_RS18650	COG3437	response regulator, receiver
EPB54_RS18660	COG0546	phosphoglycolate phosphatase activity
EPB54_RS18665	COG0840	transmembrane signaling receptor activity
EPB54_RS18675	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EPB54_RS18680	COG0513	Belongs to the DEAD box helicase family
EPB54_RS18685	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EPB54_RS18700	COG3038	cytochrome b561
EPB54_RS18705	COG2353	YceI-like domain
EPB54_RS18710	COG2116	formate transmembrane transporter activity
EPB54_RS18715	COG0583	DNA-binding transcription factor activity
EPB54_RS18725	COG3593	DNA synthesis involved in DNA repair
EPB54_RS18730	COG0737	Belongs to the 5'-nucleotidase family
EPB54_RS18735	COG0861	Integral membrane protein TerC family
EPB54_RS18750	COG2267	carboxylic ester hydrolase activity
EPB54_RS18755	COG2067	long-chain fatty acid transport protein
EPB54_RS18770	COG2050	protein possibly involved in aromatic compounds catabolism
EPB54_RS18780	COG4533	DNA binding
EPB54_RS18805	COG0484	heat shock protein binding
EPB54_RS18815	COG5001	Diguanylate cyclase
EPB54_RS18815	COG3300	MHYT domain
EPB54_RS18820	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB54_RS18830	COG4181	ATPase activity
EPB54_RS18835	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EPB54_RS18845	COG1984	allophanate hydrolase subunit 2
EPB54_RS18850	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EPB54_RS18855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EPB54_RS18860	COG5002	protein histidine kinase activity
EPB54_RS18860	COG5001	Diguanylate cyclase
EPB54_RS18860	COG3447	MASE1 domain protein
EPB54_RS18865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPB54_RS18875	COG4771	TonB-dependent receptor
EPB54_RS18875	COG1629	transport
EPB54_RS18880	COG0583	DNA-binding transcription factor activity
EPB54_RS18885	COG1042	CoA-binding domain protein
EPB54_RS18885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB54_RS18885	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB54_RS18895	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPB54_RS18905	COG0023	Translation Initiation Factor
EPB54_RS18935	COG0589	response to stress
EPB54_RS18940	COG3140	Belongs to the UPF0181 family
EPB54_RS18965	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EPB54_RS18970	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPB54_RS18995	COG2203	Gaf domain
EPB54_RS18995	COG3706	GGDEF domain
EPB54_RS18995	COG4251	negative regulation of phosphorylation
EPB54_RS18995	COG5001	Diguanylate cyclase
EPB54_RS19005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EPB54_RS19010	COG4149	molybdate abc transporter
EPB54_RS19015	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPB54_RS19020	COG1492	cobalamin metabolic process
EPB54_RS19025	COG3111	PFAM Bacterial OB fold (BOF) protein
EPB54_RS19035	COG0189	ligase activity
EPB54_RS19035	COG4067	protein conserved in archaea
EPB54_RS19055	COG0534	Mate efflux family protein
EPB54_RS19060	COG0602	queuosine metabolic process
EPB54_RS19065	COG1328	CTP reductase activity
EPB54_RS19080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB54_RS19105	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB54_RS19110	COG0243	molybdopterin cofactor binding
EPB54_RS19120	COG0583	DNA-binding transcription factor activity
EPB54_RS19125	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPB54_RS19135	COG2197	response regulator
EPB54_RS19140	COG3851	Histidine kinase
EPB54_RS19145	COG2271	Major facilitator Superfamily
EPB54_RS19170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB54_RS19175	COG3118	belongs to the thioredoxin family
EPB54_RS19185	COG3292	Two component regulator propeller
EPB54_RS19185	COG2205	protein histidine kinase activity
EPB54_RS19185	COG0745	RESPONSE REGULATOR receiver
EPB54_RS19190	COG0534	Mate efflux family protein
EPB54_RS19220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB54_RS19240	COG2116	formate transmembrane transporter activity
EPB54_RS19250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB54_RS19255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB54_RS19295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB54_RS19295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB54_RS19340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB54_RS19360	COG0277	FAD linked oxidase domain protein
EPB54_RS19365	COG0583	DNA-binding transcription factor activity
EPB54_RS19385	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EPB54_RS19400	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EPB54_RS19415	COG1288	antiporter activity
EPB54_RS19425	COG2814	Major facilitator Superfamily
EPB54_RS19435	COG3040	lipid binding
EPB54_RS19455	COG0419	ATPase involved in DNA repair
EPB54_RS19460	COG0420	3'-5' exonuclease activity
EPB54_RS19530	COG0631	protein serine/threonine phosphatase activity
EPB54_RS19565	COG2815	serine threonine protein kinase
EPB54_RS19565	COG0515	serine threonine protein kinase
EPB54_RS19620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB54_RS19620	COG2146	nitrite reductase [NAD(P)H] activity
EPB54_RS19625	COG1116	anion transmembrane transporter activity
EPB54_RS19630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPB54_RS19635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPB54_RS19645	COG3707	response regulator
EPB54_RS19670	COG0243	molybdopterin cofactor binding
EPB54_RS19680	COG0814	amino acid
EPB54_RS19710	COG1785	Belongs to the alkaline phosphatase family
EPB54_RS19725	COG0745	RESPONSE REGULATOR receiver
EPB54_RS19745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EPB54_RS19760	COG1609	Transcriptional regulator
EPB54_RS19765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB54_RS19770	COG1879	ABC-type sugar transport system periplasmic component
EPB54_RS19775	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB54_RS19780	COG1129	ABC transporter
EPB54_RS19785	COG1869	D-ribose catabolic process
EPB54_RS19790	COG5001	Diguanylate cyclase
EPB54_RS19795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB54_RS19895	COG0582	viral genome integration into host DNA
EPB54_RS19920	COG0784	Response regulator, receiver
EPB54_RS19920	COG2205	protein histidine kinase activity
EPB54_RS19940	COG3300	MHYT domain
EPB54_RS19940	COG5001	Diguanylate cyclase
EPB54_RS19950	COG0330	HflC and HflK could
EPB54_RS19965	COG0517	IMP dehydrogenase activity
EPB54_RS19965	COG4175	Glycine betaine
EPB54_RS19970	COG4176	ABC-type proline glycine betaine transport system permease component
EPB54_RS19985	COG1012	belongs to the aldehyde dehydrogenase family
EPB54_RS19990	COG1309	transcriptional regulator
EPB54_RS19995	COG3706	GGDEF domain
EPB54_RS20020	COG1024	Enoyl-CoA hydratase
EPB54_RS20025	COG1960	acyl-CoA dehydrogenase activity
EPB54_RS20035	COG0183	Belongs to the thiolase family
EPB54_RS20045	COG1960	acyl-CoA dehydrogenase activity
EPB54_RS20050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPB54_RS20060	COG4770	biotin carboxylase activity
EPB54_RS20070	COG2205	protein histidine kinase activity
EPB54_RS20070	COG3437	response regulator, receiver
EPB54_RS20070	COG4999	Histidine kinase
EPB54_RS20070	COG3850	Histidine kinase
EPB54_RS20100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB54_RS20105	COG1271	oxidase subunit
EPB54_RS20110	COG1294	oxidase, subunit
EPB54_RS20120	COG0384	phenazine biosynthesis protein PhzF
EPB54_RS20125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPB54_RS20130	COG0789	Transcriptional regulator
EPB54_RS20140	COG3474	cytochrome
EPB54_RS20145	COG1013	pyruvate-flavodoxin oxidoreductase activity
EPB54_RS20220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB54_RS20225	COG0516	GMP reductase activity
EPB54_RS20230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPB54_RS20230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPB54_RS20245	COG4989	oxidoreductase activity
EPB54_RS20260	COG0038	chloride channel
EPB54_RS20270	COG1914	H( )-stimulated, divalent metal cation uptake system
EPB54_RS20275	COG0302	gtp cyclohydrolase
EPB54_RS20285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB54_RS20305	COG2897	thiosulfate sulfurtransferase activity
EPB54_RS20330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPB54_RS20335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB54_RS20340	COG0840	transmembrane signaling receptor activity
EPB54_RS20350	COG2814	Major facilitator Superfamily
EPB54_RS20355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB54_RS20365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB54_RS20375	COG0840	transmembrane signaling receptor activity
EPB54_RS20395	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB54_RS20410	COG2197	response regulator
EPB54_RS20415	COG3850	Histidine kinase
EPB54_RS20420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB54_RS20430	COG0243	molybdopterin cofactor binding
EPB54_RS20440	COG3005	denitrification pathway
EPB54_RS20460	COG0183	Belongs to the thiolase family
EPB54_RS20480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB54_RS20485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB54_RS20510	COG1522	sequence-specific DNA binding
EPB54_RS20530	COG1566	PFAM secretion protein HlyD family protein
EPB54_RS20540	COG2205	protein histidine kinase activity
EPB54_RS20540	COG0784	Response regulator, receiver
EPB54_RS20545	COG1879	ABC-type sugar transport system periplasmic component
EPB54_RS20550	COG2827	Endonuclease containing a URI domain
EPB54_RS20555	COG3132	Protein of unknown function, DUF480
EPB54_RS20570	COG2926	Belongs to the UPF0265 family
EPB54_RS20575	COG0534	Mate efflux family protein
EPB54_RS20580	COG0673	inositol 2-dehydrogenase activity
EPB54_RS20585	COG2205	protein histidine kinase activity
EPB54_RS20585	COG5002	protein histidine kinase activity
EPB54_RS20585	COG0784	Response regulator, receiver
EPB54_RS20610	COG1522	sequence-specific DNA binding
EPB54_RS20620	COG0531	amino acid
EPB54_RS20635	COG2205	protein histidine kinase activity
EPB54_RS20640	COG0745	RESPONSE REGULATOR receiver
EPB54_RS20665	COG1566	PFAM secretion protein HlyD family protein
EPB54_RS20670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPB54_RS20675	COG2239	Acts as a magnesium transporter
EPB54_RS20685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EPB54_RS20690	COG0402	S-adenosylhomocysteine deaminase activity
EPB54_RS20700	COG1418	mRNA catabolic process
EPB54_RS20715	COG2814	Major facilitator Superfamily
EPB54_RS20725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB54_RS20745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB54_RS20765	COG4221	oxidoreductase activity
EPB54_RS20770	COG0745	RESPONSE REGULATOR receiver
EPB54_RS20775	COG2205	protein histidine kinase activity
EPB54_RS20785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB54_RS20790	COG2194	sulfuric ester hydrolase activity
EPB54_RS20795	COG0673	inositol 2-dehydrogenase activity
EPB54_RS20805	COG2814	Major facilitator Superfamily
EPB54_RS20830	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB54_RS20835	COG1741	Belongs to the pirin family
EPB54_RS20840	COG1278	Cold shock
EPB54_RS20860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB54_RS20880	COG1686	Belongs to the peptidase S11 family
EPB54_RS20890	COG0625	glutathione transferase activity
EPB54_RS20900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPB54_RS20925	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS20945	COG3746	phosphate-selective porin O and P
EPB54_RS20965	COG3833	ABC-type maltose transport systems, permease component
EPB54_RS20970	COG1175	transmembrane transport
EPB54_RS20980	COG3842	ATPase activity
EPB54_RS20985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB54_RS21040	COG3097	Belongs to the UPF0267 family
EPB54_RS21045	COG1309	transcriptional regulator
EPB54_RS21050	COG2130	NADP-dependent
EPB54_RS21060	COG0753	catalase activity
EPB54_RS21065	COG2084	Dehydrogenase
EPB54_RS21070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB54_RS21075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB54_RS21085	COG2207	Transcriptional regulator
EPB54_RS21090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB54_RS21090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB54_RS21090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB54_RS21105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB54_RS21110	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
EPB54_RS21120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB54_RS21125	COG0569	domain protein
EPB54_RS21135	COG2205	protein histidine kinase activity
EPB54_RS21140	COG1132	(ABC) transporter
EPB54_RS21145	COG4774	siderophore transport
EPB54_RS21150	COG1120	ATPase activity
EPB54_RS21155	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EPB54_RS21215	COG0840	transmembrane signaling receptor activity
EPB54_RS21225	COG0714	Associated with various cellular activities
EPB54_RS21245	COG2304	oxidoreductase activity
EPB54_RS21260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB54_RS21265	COG0581	inorganic phosphate transmembrane transporter activity
EPB54_RS21270	COG0573	inorganic phosphate transmembrane transporter activity
EPB54_RS21300	COG4771	TonB-dependent receptor
EPB54_RS21305	COG1770	oligopeptidase
EPB54_RS21310	COG0513	Belongs to the DEAD box helicase family
EPB54_RS21320	COG1388	LysM domain
EPB54_RS21320	COG1376	ErfK ybiS ycfS ynhG family protein
EPB54_RS21325	COG0415	Belongs to the DNA photolyase family
EPB54_RS21330	COG0789	Transcriptional regulator
EPB54_RS21335	COG3272	Protein of unknown function (DUF1722)
EPB54_RS21345	COG0813	purine-nucleoside phosphorylase activity
EPB54_RS21360	COG3706	GGDEF domain
EPB54_RS21370	COG1566	PFAM secretion protein HlyD family protein
EPB54_RS21375	COG4720	Psort location CytoplasmicMembrane, score
EPB54_RS21380	COG1122	ATPase activity
EPB54_RS21395	COG0348	domain, Protein
EPB54_RS21400	COG0437	4 iron, 4 sulfur cluster binding
EPB54_RS21405	COG1247	-acetyltransferase
EPB54_RS21435	COG1067	ATP-dependent peptidase activity
EPB54_RS21445	COG4172	Belongs to the ABC transporter superfamily
EPB54_RS21450	COG1505	serine-type exopeptidase activity
EPB54_RS21455	COG0583	DNA-binding transcription factor activity
EPB54_RS21460	COG1620	l-lactate permease
EPB54_RS21465	COG1304	FMN binding
EPB54_RS21475	COG0668	transmembrane transport
EPB54_RS21515	COG1063	alcohol dehydrogenase
EPB54_RS21520	COG0156	8-amino-7-oxononanoate synthase activity
EPB54_RS21530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB54_RS21550	COG0745	RESPONSE REGULATOR receiver
EPB54_RS21585	COG0346	lactoylglutathione lyase activity
EPB54_RS21605	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPB54_RS21685	COG1987	bacterial-type flagellum assembly
EPB54_RS21695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EPB54_RS21710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS21720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB54_RS21725	COG1516	flagellar protein fliS
EPB54_RS21740	COG1580	Controls the rotational direction of flagella during chemotaxis
EPB54_RS21745	COG1191	sigma factor activity
EPB54_RS21750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB54_RS21755	COG1360	Flagellar Motor Protein
EPB54_RS21785	COG1882	Formate acetyltransferase
EPB54_RS21790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB54_RS21795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPB54_RS21805	COG0454	-acetyltransferase
EPB54_RS21815	COG2814	Major facilitator Superfamily
EPB54_RS21860	COG0628	permease
EPB54_RS21865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB54_RS21875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB54_RS21885	COG4628	conserved protein (DUF2132)
EPB54_RS21890	COG0583	DNA-binding transcription factor activity
EPB54_RS21915	COG1686	Belongs to the peptidase S11 family
EPB54_RS21930	COG1054	Belongs to the UPF0176 family
EPB54_RS21935	COG3397	chitin binding
EPB54_RS21940	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB54_RS21945	COG2095	MarC family integral membrane protein
EPB54_RS21965	COG0489	protein tyrosine kinase activity
EPB54_RS21965	COG3206	protein involved in exopolysaccharide biosynthesis
EPB54_RS21980	COG0583	DNA-binding transcription factor activity
EPB54_RS21990	COG1301	dicarboxylic acid transport
EPB54_RS21995	COG3339	Conserved Protein
EPB54_RS22000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB54_RS22005	COG0700	Nucleoside recognition
EPB54_RS22010	COG3366	ferrous iron transmembrane transporter activity
EPB54_RS22025	COG0366	Alpha amylase catalytic
EPB54_RS22030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB54_RS22035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPB54_RS22040	COG1640	4-alpha-glucanotransferase
EPB54_RS22045	COG0058	SHG alpha-glucan phosphorylase activity
EPB54_RS22060	COG2909	trisaccharide binding
EPB54_RS22075	COG1999	signal sequence binding
EPB54_RS22085	COG1263	PTS System
EPB54_RS22085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB54_RS22090	COG1162	GTPase activity
EPB54_RS22095	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EPB54_RS22105	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EPB54_RS22115	COG0531	amino acid
EPB54_RS22120	COG1982	Orn Lys Arg decarboxylase major
EPB54_RS22140	COG2356	endonuclease I
EPB54_RS22165	COG4580	involved in the transport of maltose and maltodextrins
EPB54_RS22190	COG0739	heme binding
EPB54_RS22200	COG0612	Peptidase, M16
EPB54_RS22205	COG0840	transmembrane signaling receptor activity
EPB54_RS22210	COG1120	ATPase activity
EPB54_RS22215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB54_RS22220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB54_RS22225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EPB54_RS22230	COG4772	TonB-dependent receptor
EPB54_RS22250	COG2814	Major facilitator Superfamily
EPB54_RS22255	COG4264	IucA IucC family
EPB54_RS22260	COG0019	diaminopimelate decarboxylase activity
EPB54_RS22265	COG1653	transport
EPB54_RS22295	COG0826	peptidase U32
EPB54_RS22315	COG0463	Glycosyl transferase, family 2
EPB54_RS22335	COG1764	response to oxidative stress
EPB54_RS22340	COG1846	Transcriptional regulator
EPB54_RS22350	COG3634	alkyl hydroperoxide reductase activity
EPB54_RS22390	COG1595	DNA-templated transcription, initiation
EPB54_RS22410	COG0583	DNA-binding transcription factor activity
EPB54_RS22415	COG1486	melibiose metabolic process
EPB54_RS22430	COG2258	MOSC domain
EPB54_RS22435	COG0513	Belongs to the DEAD box helicase family
EPB54_RS22440	COG1312	Catalyzes the dehydration of D-mannonate
EPB54_RS22445	COG2186	Transcriptional regulator
EPB54_RS22455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB54_RS22465	COG0246	Mannitol dehydrogenase
EPB54_RS22470	COG1904	glucuronate isomerase
EPB54_RS22475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB54_RS22480	COG0800	Aldolase
EPB54_RS22515	COG1132	(ABC) transporter
EPB54_RS22560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB54_RS22590	COG0259	pyridoxamine-phosphate oxidase activity
EPB54_RS22635	COG4166	transmembrane transport
EPB54_RS22655	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPB54_RS22660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB54_RS22660	COG1263	PTS System
EPB54_RS22665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB54_RS22670	COG3340	Belongs to the peptidase S51 family
EPB54_RS22690	COG1444	tRNA N-acetyltransferase activity
EPB54_RS22715	COG4608	Belongs to the ABC transporter superfamily
EPB54_RS22720	COG0444	Belongs to the ABC transporter superfamily
EPB54_RS22730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB54_RS22730	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
EPB54_RS22755	COG0217	transcriptional regulatory protein
EPB54_RS22760	COG0772	Belongs to the SEDS family
EPB54_RS22775	COG1136	(ABC) transporter
EPB54_RS22795	COG3275	phosphorelay sensor kinase activity
EPB54_RS22800	COG3279	Response regulator of the LytR AlgR family
EPB54_RS22810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB54_RS22845	COG0786	glutamate:sodium symporter activity
EPB54_RS22855	COG1131	(ABC) transporter
EPB54_RS22860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB54_RS22865	COG0786	glutamate:sodium symporter activity
EPB54_RS22880	COG0363	glucosamine-6-phosphate deaminase activity
EPB54_RS22900	COG1741	Belongs to the pirin family
EPB54_RS22905	COG2259	Doxx family
EPB54_RS22920	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EPB54_RS22925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPB54_RS22935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EPB54_RS22975	COG3123	guanosine phosphorylase activity
EPB54_RS22985	COG5001	Diguanylate cyclase
EPB54_RS22995	COG0534	Mate efflux family protein
EPB54_RS23000	COG0564	pseudouridine synthase activity
EPB54_RS23015	COG0583	DNA-binding transcription factor activity
EPB54_RS23020	COG0561	phosphatase activity
EPB54_RS23030	COG2199	diguanylate cyclase activity
EPB54_RS23045	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EPB54_RS23050	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EPB54_RS23055	COG0583	DNA-binding transcription factor activity
EPB54_RS23070	COG1414	Transcriptional regulator
EPB54_RS23075	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS23085	COG1917	Cupin 2, conserved barrel domain protein
EPB54_RS23100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB54_RS23105	COG0800	Aldolase
EPB54_RS23125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB54_RS23130	COG0823	Involved in the tonB-independent uptake of proteins
EPB54_RS23135	COG2375	cellular response to nickel ion
EPB54_RS23165	COG1357	PFAM Pentapeptide repeats (8 copies)
EPB54_RS23170	COG3047	cAMP biosynthetic process
EPB54_RS23180	COG2814	Major facilitator Superfamily
EPB54_RS23200	COG3408	Glycogen debranching enzyme
EPB54_RS23200	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EPB54_RS23205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EPB54_RS23215	COG0583	DNA-binding transcription factor activity
EPB54_RS23225	COG0583	DNA-binding transcription factor activity
EPB54_RS23260	COG3835	regulator
EPB54_RS23265	COG2610	gluconate transmembrane transporter activity
EPB54_RS23270	COG1929	Belongs to the glycerate kinase type-1 family
EPB54_RS23275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB54_RS23295	COG0456	acetyltransferase
EPB54_RS23310	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS23320	COG3005	denitrification pathway
EPB54_RS23325	COG0243	molybdopterin cofactor binding
EPB54_RS23335	COG0352	thiamine-phosphate diphosphorylase activity
EPB54_RS23340	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EPB54_RS23345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EPB54_RS23350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPB54_RS23355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPB54_RS23360	COG1116	anion transmembrane transporter activity
EPB54_RS23365	COG0351	phosphomethylpyrimidine kinase
EPB54_RS23375	COG0312	modulator of DNA gyrase
EPB54_RS23380	COG0312	modulator of DNA gyrase
EPB54_RS23385	COG1901	pseudouridine methyltransferase
EPB54_RS23445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB54_RS23455	COG0584	glycerophosphoryl diester phosphodiesterase
EPB54_RS23460	COG0039	L-malate dehydrogenase activity
EPB54_RS23465	COG0745	RESPONSE REGULATOR receiver
EPB54_RS23485	COG0811	peptide transport
EPB54_RS23490	COG0811	peptide transport
EPB54_RS23495	COG0848	biopolymer transport protein
EPB54_RS23535	COG0803	Belongs to the bacterial solute-binding protein 9 family
EPB54_RS23540	COG1121	(ABC) transporter
EPB54_RS23545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB54_RS23560	COG1770	oligopeptidase
EPB54_RS23565	COG2814	Major facilitator Superfamily
EPB54_RS23570	COG0010	Belongs to the arginase family
EPB54_RS23575	COG1166	arginine decarboxylase activity
EPB54_RS23585	COG4067	protein conserved in archaea
EPB54_RS23585	COG0189	ligase activity
EPB54_RS23590	COG0189	ligase activity
EPB54_RS23600	COG0583	DNA-binding transcription factor activity
EPB54_RS23635	COG4191	Histidine kinase
EPB54_RS23645	COG2199	diguanylate cyclase activity
EPB54_RS23675	COG0579	oxidoreductase
EPB54_RS23685	COG3033	Beta-eliminating lyase
EPB54_RS23705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB54_RS23720	COG3706	GGDEF domain
EPB54_RS23725	COG0840	transmembrane signaling receptor activity
EPB54_RS23740	COG3706	GGDEF domain
EPB54_RS23745	COG0415	Belongs to the DNA photolyase family
EPB54_RS23750	COG3046	protein related to deoxyribodipyrimidine photolyase
EPB54_RS23765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB54_RS23765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB54_RS23770	COG1765	OsmC-like protein
EPB54_RS23775	COG0110	maltose O-acetyltransferase activity
EPB54_RS23815	COG1011	Hydrolase
EPB54_RS23830	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EPB54_RS23835	COG3338	carbonate dehydratase activity
EPB54_RS23840	COG2067	long-chain fatty acid transport protein
EPB54_RS23845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB54_RS23850	COG0577	efflux transmembrane transporter activity
EPB54_RS23850	COG1136	(ABC) transporter
EPB54_RS23860	COG3240	lipase activity
EPB54_RS23890	COG1609	Transcriptional regulator
EPB54_RS23895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB54_RS23900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB54_RS23910	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB54_RS23920	COG3842	ATPase activity
EPB54_RS23945	COG2990	Protein conserved in bacteria
EPB54_RS23955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB54_RS23960	COG2866	Carboxypeptidase
EPB54_RS23975	COG0583	DNA-binding transcription factor activity
EPB54_RS23995	COG3104	oligopeptide transport
EPB54_RS24000	COG1760	l-serine dehydratase
EPB54_RS24020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPB54_RS24030	COG0741	lytic transglycosylase activity
EPB54_RS24050	COG1815	bacterial-type flagellum-dependent cell motility
EPB54_RS24055	COG1558	bacterial-type flagellum-dependent cell motility
EPB54_RS24060	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EPB54_RS24065	COG1749	Flagellar hook protein flgE
EPB54_RS24070	COG4787	bacterial-type flagellum-dependent cell motility
EPB54_RS24075	COG4786	Flagellar basal body rod
EPB54_RS24080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB54_RS24085	COG1706	bacterial-type flagellum-dependent cell motility
EPB54_RS24100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB54_RS24120	COG1304	FMN binding
EPB54_RS24150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB54_RS24160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPB54_RS24165	COG0459	protein refolding
EPB54_RS24180	COG1280	lysine exporter protein (LysE YggA)
EPB54_RS24200	COG1309	transcriptional regulator
EPB54_RS24210	COG0737	Belongs to the 5'-nucleotidase family
EPB54_RS24215	COG2070	2-Nitropropane dioxygenase
EPB54_RS24220	COG3537	Alpha-1,2-mannosidase
EPB54_RS24235	COG3537	Alpha-1,2-mannosidase
EPB54_RS24240	COG3537	Alpha-1,2-mannosidase
EPB54_RS24245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB54_RS24255	COG0583	DNA-binding transcription factor activity
EPB54_RS24270	COG0346	lactoylglutathione lyase activity
EPB54_RS24275	COG1349	DNA-binding transcription factor activity
EPB54_RS24285	COG0753	catalase activity
EPB54_RS24295	COG1335	isochorismatase
EPB54_RS24305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EPB54_RS24335	COG0583	DNA-binding transcription factor activity
EPB54_RS24350	COG3713	MltA-interacting MipA family protein
EPB54_RS24360	COG3015	lipoprotein NlpE involved in copper resistance
EPB54_RS24370	COG1342	Belongs to the UPF0251 family
EPB54_RS24405	COG4948	Mandelate Racemase Muconate Lactonizing
EPB54_RS24415	COG0583	DNA-binding transcription factor activity
EPB54_RS24465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB54_RS24510	COG3842	ATPase activity
EPB54_RS24540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB54_RS24550	COG2197	response regulator
EPB54_RS24560	COG3706	GGDEF domain
EPB54_RS24580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB54_RS24600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB54_RS24620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB54_RS24620	COG0574	Belongs to the PEP-utilizing enzyme family
EPB54_RS24625	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EPB54_RS24630	COG0252	asparaginase activity
EPB54_RS24635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB54_RS24640	COG0583	DNA-binding transcription factor activity
EPB54_RS24655	COG3122	Protein conserved in bacteria
EPB54_RS24670	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS24680	COG1063	alcohol dehydrogenase
EPB54_RS24685	COG1902	pentaerythritol trinitrate reductase activity
EPB54_RS24700	COG0583	DNA-binding transcription factor activity
EPB54_RS24710	COG0513	Belongs to the DEAD box helicase family
EPB54_RS24755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB54_RS24760	COG2207	Transcriptional regulator
EPB54_RS24760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB54_RS24790	COG2354	Protein conserved in bacteria
EPB54_RS24795	COG0418	dihydroorotase activity
EPB54_RS24805	COG0401	homolog of Blt101
EPB54_RS24815	COG0633	Ferredoxin
EPB54_RS24815	COG3217	Mosc domain protein beta barrel domain protein
EPB54_RS24815	COG0633	Ferredoxin
EPB54_RS24815	COG3217	Mosc domain protein beta barrel domain protein
EPB54_RS24820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPB54_RS24825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EPB54_RS24865	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EPB54_RS24870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB54_RS24880	COG0848	biopolymer transport protein
EPB54_RS24885	COG0811	peptide transport
EPB54_RS24890	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPB54_RS24900	COG3721	Heme iron utilization protein
EPB54_RS24905	COG0748	coenzyme F420 binding
EPB54_RS24915	COG0835	chemotaxis
EPB54_RS24915	COG0784	Response regulator, receiver
EPB54_RS24925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB54_RS24935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB54_RS24935	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EPB54_RS24960	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EPB54_RS24965	COG0783	Belongs to the Dps family
EPB54_RS24975	COG0583	DNA-binding transcription factor activity
EPB54_RS24990	COG4934	collagen metabolic process
EPB54_RS25000	COG0366	Alpha amylase catalytic
EPB54_RS25020	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB54_RS25025	COG0589	response to stress
EPB54_RS25030	COG0488	(ABC) transporter
EPB54_RS25035	COG1505	serine-type exopeptidase activity
EPB54_RS25045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB54_RS25055	COG2067	long-chain fatty acid transport protein
EPB54_RS25065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB54_RS25095	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB54_RS25120	COG3383	formate dehydrogenase (NAD+) activity
EPB54_RS25135	COG0842	Transport permease protein
EPB54_RS25140	COG1131	(ABC) transporter
EPB54_RS25155	COG2706	6-phosphogluconolactonase activity
EPB54_RS25165	COG1881	PFAM PEBP family protein
EPB54_RS25175	COG0798	PFAM Bile acid sodium symporter
EPB54_RS25195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB54_RS25200	COG2213	PTS system mannitol-specific
EPB54_RS25205	COG1063	alcohol dehydrogenase
EPB54_RS25215	COG1072	(Pantothenic acid kinase))
EPB54_RS25220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPB54_RS25240	COG0814	amino acid
EPB54_RS25255	COG3314	Sporulation integral membrane protein YlbJ
EPB54_RS25280	COG0739	heme binding
EPB54_RS25285	COG5001	Diguanylate cyclase
EPB54_RS25290	COG0583	DNA-binding transcription factor activity
EPB54_RS25295	COG2814	Major facilitator Superfamily
EPB54_RS25320	COG0697	spore germination
EPB54_RS25350	COG2207	Transcriptional regulator
EPB54_RS25355	COG1280	lysine exporter protein (LysE YggA)
EPB54_RS25365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB54_RS25370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB54_RS25380	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EPB54_RS25405	COG1612	heme a metabolic process
EPB54_RS25410	COG0109	protoheme IX farnesyltransferase activity
EPB54_RS25415	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB54_RS25450	COG1278	Cold shock
EPB54_RS25470	COG2199	diguanylate cyclase activity
EPB54_RS25490	COG0577	efflux transmembrane transporter activity
EPB54_RS25490	COG1136	(ABC) transporter
EPB54_RS25500	COG0840	transmembrane signaling receptor activity
EPB54_RS25505	COG0783	Belongs to the Dps family
EPB54_RS25515	COG2133	pyrroloquinoline quinone binding
EPB54_RS25520	COG1454	alcohol dehydrogenase
EPB54_RS25525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EPB54_RS25555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB54_RS25560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB54_RS25565	COG3186	Phenylalanine-4-hydroxylase
EPB54_RS25570	COG2154	pterin-4-alpha-carbinolamine dehydratase
EPB54_RS25595	COG3530	Putative quorum-sensing-regulated virulence factor
EPB54_RS25600	COG0513	Belongs to the DEAD box helicase family
EPB54_RS25605	COG4628	conserved protein (DUF2132)
EPB54_RS25610	COG0133	tryptophan synthase activity
EPB54_RS25620	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EPB54_RS25630	COG0523	cobalamin synthesis protein
EPB54_RS25635	COG0513	Belongs to the DEAD box helicase family
EPB54_RS25655	COG2200	EAL domain
EPB54_RS25660	COG1119	ATPase activity
EPB54_RS25665	COG0840	transmembrane signaling receptor activity
EPB54_RS25685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPB54_RS25700	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EPB54_RS25705	COG0513	Belongs to the DEAD box helicase family
EPB54_RS25720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB54_RS25735	COG5413	integral membrane protein
EPB54_RS25745	COG1024	Enoyl-CoA hydratase
EPB54_RS25750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPB54_RS25755	COG1960	acyl-CoA dehydrogenase activity
EPB54_RS25765	COG0183	Belongs to the thiolase family
EPB54_RS25780	COG1024	Enoyl-CoA hydratase
EPB54_RS25785	COG1024	Enoyl-CoA hydratase
EPB54_RS25795	COG1028	Short-chain dehydrogenase reductase Sdr
EPB54_RS25800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB54_RS25805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPB54_RS25810	COG1845	cytochrome c oxidase, subunit III
EPB54_RS25815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EPB54_RS25820	COG0109	protoheme IX farnesyltransferase activity
EPB54_RS25835	COG1902	pentaerythritol trinitrate reductase activity
EPB54_RS25845	COG1126	abc transporter atp-binding protein
EPB54_RS25850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB54_RS25855	COG4215	(ABC) transporter
EPB54_RS25860	COG4160	amino acid transport
EPB54_RS25875	COG0625	glutathione transferase activity
EPB54_RS25910	COG0443	Heat shock 70 kDa protein
EPB54_RS25915	COG2847	Copper chaperone PCu(A)C
EPB54_RS25940	COG4607	ABC-type enterochelin transport system periplasmic component
EPB54_RS25945	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB54_RS25950	COG4605	iron ion homeostasis
EPB54_RS25955	COG4604	ABC transporter, ATP-binding protein
EPB54_RS25960	COG0789	Transcriptional regulator
EPB54_RS25970	COG2207	Transcriptional regulator
EPB54_RS25975	COG1629	transport
EPB54_RS25975	COG4771	TonB-dependent receptor
EPB54_RS26010	COG1289	transmembrane transporter activity
EPB54_RS26015	COG0210	DNA helicase
EPB54_RS26020	COG1803	Methylglyoxal synthase
EPB54_RS26025	COG1879	ABC-type sugar transport system periplasmic component
EPB54_RS26030	COG2198	Histidine kinase
EPB54_RS26030	COG2205	protein histidine kinase activity
EPB54_RS26030	COG0784	Response regulator, receiver
EPB54_RS26045	COG0745	RESPONSE REGULATOR receiver
EPB54_RS26050	COG3119	arylsulfatase activity
EPB54_RS26055	COG3119	arylsulfatase activity
EPB54_RS26070	COG3119	arylsulfatase activity
EPB54_RS26075	COG0641	radical SAM
EPB54_RS26080	COG0714	Associated with various cellular activities
EPB54_RS26110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB54_RS26115	COG0583	DNA-binding transcription factor activity
EPB54_RS26120	COG1597	lipid kinase activity
EPB54_RS26125	COG3111	PFAM Bacterial OB fold (BOF) protein
EPB54_RS26145	COG0641	radical SAM
EPB54_RS26175	COG0501	Belongs to the peptidase M48B family
EPB54_RS26180	COG1704	LemA family
EPB54_RS26185	COG3069	C4-dicarboxylate transmembrane transporter activity
EPB54_RS26195	COG1214	PFAM Peptidase M22, glycoprotease
EPB54_RS26195	COG0456	acetyltransferase
EPB54_RS26215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EPB54_RS26235	COG2207	Transcriptional regulator
EPB54_RS26260	COG4964	Belongs to the GSP D family
EPB54_RS26320	COG0583	DNA-binding transcription factor activity
EPB54_RS26325	COG0583	DNA-binding transcription factor activity
EPB54_RS26340	COG5001	Diguanylate cyclase
EPB54_RS26340	COG3300	MHYT domain
EPB54_RS26345	COG2197	response regulator
EPB54_RS26350	COG3706	GGDEF domain
EPB54_RS26360	COG2197	response regulator
EPB54_RS26385	COG0835	chemotaxis
EPB54_RS26385	COG0784	Response regulator, receiver
EPB54_RS26405	COG2962	Rard protein
EPB54_RS26420	COG0671	phosphoesterase, PA-phosphatase related
EPB54_RS26435	COG2076	Multidrug Resistance protein
EPB54_RS26465	COG0471	metal ion transport
EPB54_RS26470	COG3290	protein histidine kinase activity
EPB54_RS26475	COG4565	transcriptional regulatory protein
EPB54_RS26495	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EPB54_RS26500	COG5642	Protein of unknown function (DUF2384)