locus-tag	class	description
GPY55_RS00035	COG3833	ABC-type maltose transport systems, permease component
GPY55_RS00040	COG1175	transmembrane transport
GPY55_RS00050	COG3842	ATPase activity
GPY55_RS00115	COG1309	transcriptional regulator
GPY55_RS00120	COG2130	NADP-dependent
GPY55_RS00130	COG0753	catalase activity
GPY55_RS00135	COG2084	Dehydrogenase
GPY55_RS00140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY55_RS00145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY55_RS00155	COG2207	Transcriptional regulator
GPY55_RS00160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS00160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY55_RS00160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY55_RS00175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY55_RS00180	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY55_RS00190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY55_RS00195	COG0569	domain protein
GPY55_RS00200	COG0745	RESPONSE REGULATOR receiver
GPY55_RS00205	COG2205	protein histidine kinase activity
GPY55_RS00210	COG1132	(ABC) transporter
GPY55_RS00215	COG4774	siderophore transport
GPY55_RS00220	COG1120	ATPase activity
GPY55_RS00225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY55_RS00260	COG2197	response regulator
GPY55_RS00270	COG0840	transmembrane signaling receptor activity
GPY55_RS00280	COG0714	Associated with various cellular activities
GPY55_RS00300	COG2304	oxidoreductase activity
GPY55_RS00320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY55_RS00325	COG0581	inorganic phosphate transmembrane transporter activity
GPY55_RS00330	COG0573	inorganic phosphate transmembrane transporter activity
GPY55_RS00335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY55_RS00360	COG4771	TonB-dependent receptor
GPY55_RS00365	COG1770	oligopeptidase
GPY55_RS00370	COG0513	Belongs to the DEAD box helicase family
GPY55_RS00380	COG1376	ErfK ybiS ycfS ynhG family protein
GPY55_RS00380	COG1388	LysM domain
GPY55_RS00385	COG0415	Belongs to the DNA photolyase family
GPY55_RS00390	COG0789	Transcriptional regulator
GPY55_RS00395	COG3272	Protein of unknown function (DUF1722)
GPY55_RS00405	COG0813	purine-nucleoside phosphorylase activity
GPY55_RS00420	COG3706	GGDEF domain
GPY55_RS00430	COG1566	PFAM secretion protein HlyD family protein
GPY55_RS00435	COG4720	Psort location CytoplasmicMembrane, score
GPY55_RS00440	COG1122	ATPase activity
GPY55_RS00455	COG0348	domain, Protein
GPY55_RS00460	COG0437	4 iron, 4 sulfur cluster binding
GPY55_RS00465	COG1247	-acetyltransferase
GPY55_RS00495	COG1067	ATP-dependent peptidase activity
GPY55_RS00505	COG4172	Belongs to the ABC transporter superfamily
GPY55_RS00510	COG1505	serine-type exopeptidase activity
GPY55_RS00515	COG0583	DNA-binding transcription factor activity
GPY55_RS00520	COG1620	l-lactate permease
GPY55_RS00525	COG1304	FMN binding
GPY55_RS00535	COG0668	transmembrane transport
GPY55_RS00575	COG1063	alcohol dehydrogenase
GPY55_RS00580	COG0156	8-amino-7-oxononanoate synthase activity
GPY55_RS00590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY55_RS00610	COG0745	RESPONSE REGULATOR receiver
GPY55_RS00645	COG0346	lactoylglutathione lyase activity
GPY55_RS00665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY55_RS00705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY55_RS00720	COG2204	response regulator
GPY55_RS00745	COG1987	bacterial-type flagellum assembly
GPY55_RS00770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY55_RS00785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY55_RS00790	COG1516	flagellar protein fliS
GPY55_RS00805	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY55_RS00810	COG1191	sigma factor activity
GPY55_RS00815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY55_RS00820	COG1360	Flagellar Motor Protein
GPY55_RS00855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY55_RS00860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY55_RS00870	COG0454	-acetyltransferase
GPY55_RS00880	COG2814	Major facilitator Superfamily
GPY55_RS00925	COG0628	permease
GPY55_RS00930	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY55_RS00940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY55_RS00950	COG4628	conserved protein (DUF2132)
GPY55_RS00955	COG0583	DNA-binding transcription factor activity
GPY55_RS00980	COG1686	Belongs to the peptidase S11 family
GPY55_RS01000	COG3397	chitin binding
GPY55_RS01005	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY55_RS01010	COG2095	MarC family integral membrane protein
GPY55_RS01035	COG0583	DNA-binding transcription factor activity
GPY55_RS01045	COG1301	dicarboxylic acid transport
GPY55_RS01055	COG3339	Conserved Protein
GPY55_RS01060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY55_RS01065	COG0700	Nucleoside recognition
GPY55_RS01070	COG3366	ferrous iron transmembrane transporter activity
GPY55_RS01085	COG0366	Alpha amylase catalytic
GPY55_RS01090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY55_RS01095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY55_RS01100	COG1640	4-alpha-glucanotransferase
GPY55_RS01105	COG0058	SHG alpha-glucan phosphorylase activity
GPY55_RS01120	COG2909	trisaccharide binding
GPY55_RS01135	COG1999	signal sequence binding
GPY55_RS01145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY55_RS01145	COG1263	PTS System
GPY55_RS01150	COG1162	GTPase activity
GPY55_RS01155	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY55_RS01165	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY55_RS01175	COG0531	amino acid
GPY55_RS01180	COG1982	Orn Lys Arg decarboxylase major
GPY55_RS01200	COG2356	endonuclease I
GPY55_RS01225	COG4580	involved in the transport of maltose and maltodextrins
GPY55_RS01240	COG2814	Major facilitator Superfamily
GPY55_RS01250	COG0739	heme binding
GPY55_RS01260	COG0612	Peptidase, M16
GPY55_RS01265	COG0840	transmembrane signaling receptor activity
GPY55_RS01270	COG1120	ATPase activity
GPY55_RS01275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY55_RS01280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY55_RS01285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY55_RS01290	COG4772	TonB-dependent receptor
GPY55_RS01315	COG4264	IucA IucC family
GPY55_RS01320	COG0019	diaminopimelate decarboxylase activity
GPY55_RS01325	COG1653	transport
GPY55_RS01335	COG0745	RESPONSE REGULATOR receiver
GPY55_RS01360	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY55_RS01365	COG1129	ABC transporter
GPY55_RS01370	COG1879	ABC-type sugar transport system periplasmic component
GPY55_RS01375	COG1069	ribulokinase activity
GPY55_RS01385	COG2160	L-arabinose isomerase activity
GPY55_RS01410	COG1764	response to oxidative stress
GPY55_RS01415	COG1846	Transcriptional regulator
GPY55_RS01420	COG0450	alkyl hydroperoxide reductase
GPY55_RS01425	COG3634	alkyl hydroperoxide reductase activity
GPY55_RS01455	COG1595	DNA-templated transcription, initiation
GPY55_RS01470	COG0840	transmembrane signaling receptor activity
GPY55_RS01475	COG0583	DNA-binding transcription factor activity
GPY55_RS01480	COG1486	melibiose metabolic process
GPY55_RS01495	COG2258	MOSC domain
GPY55_RS01500	COG0513	Belongs to the DEAD box helicase family
GPY55_RS01515	COG2207	Transcriptional regulator
GPY55_RS01525	COG1132	(ABC) transporter
GPY55_RS01570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY55_RS01600	COG0259	pyridoxamine-phosphate oxidase activity
GPY55_RS01645	COG4166	transmembrane transport
GPY55_RS01665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY55_RS01670	COG1263	PTS System
GPY55_RS01670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY55_RS01675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY55_RS01680	COG3340	Belongs to the peptidase S51 family
GPY55_RS01700	COG1444	tRNA N-acetyltransferase activity
GPY55_RS01725	COG4608	Belongs to the ABC transporter superfamily
GPY55_RS01730	COG0444	Belongs to the ABC transporter superfamily
GPY55_RS01740	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY55_RS01740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY55_RS01765	COG0217	transcriptional regulatory protein
GPY55_RS01770	COG0772	Belongs to the SEDS family
GPY55_RS01785	COG1136	(ABC) transporter
GPY55_RS01805	COG3275	phosphorelay sensor kinase activity
GPY55_RS01810	COG3279	Response regulator of the LytR AlgR family
GPY55_RS01820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY55_RS01855	COG0786	glutamate:sodium symporter activity
GPY55_RS01865	COG1131	(ABC) transporter
GPY55_RS01870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY55_RS01875	COG0786	glutamate:sodium symporter activity
GPY55_RS01890	COG0363	glucosamine-6-phosphate deaminase activity
GPY55_RS01910	COG1741	Belongs to the pirin family
GPY55_RS01915	COG2259	Doxx family
GPY55_RS01930	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY55_RS01935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY55_RS01945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY55_RS01985	COG3123	guanosine phosphorylase activity
GPY55_RS01995	COG5001	Diguanylate cyclase
GPY55_RS02005	COG0534	Mate efflux family protein
GPY55_RS02010	COG0564	pseudouridine synthase activity
GPY55_RS02025	COG0583	DNA-binding transcription factor activity
GPY55_RS02030	COG0561	phosphatase activity
GPY55_RS02040	COG2199	diguanylate cyclase activity
GPY55_RS02055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY55_RS02060	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY55_RS02065	COG0583	DNA-binding transcription factor activity
GPY55_RS02080	COG1414	Transcriptional regulator
GPY55_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS02095	COG1917	Cupin 2, conserved barrel domain protein
GPY55_RS02110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY55_RS02115	COG0800	Aldolase
GPY55_RS02135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY55_RS02140	COG0823	Involved in the tonB-independent uptake of proteins
GPY55_RS02145	COG2375	cellular response to nickel ion
GPY55_RS02175	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY55_RS02180	COG3047	cAMP biosynthetic process
GPY55_RS02210	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY55_RS02210	COG3408	Glycogen debranching enzyme
GPY55_RS02215	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GPY55_RS02235	COG0583	DNA-binding transcription factor activity
GPY55_RS02250	COG0546	phosphoglycolate phosphatase activity
GPY55_RS02275	COG3835	regulator
GPY55_RS02280	COG2610	gluconate transmembrane transporter activity
GPY55_RS02285	COG1929	Belongs to the glycerate kinase type-1 family
GPY55_RS02290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY55_RS02310	COG0456	acetyltransferase
GPY55_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS02335	COG3005	denitrification pathway
GPY55_RS02340	COG0243	molybdopterin cofactor binding
GPY55_RS02350	COG0352	thiamine-phosphate diphosphorylase activity
GPY55_RS02355	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY55_RS02360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY55_RS02365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY55_RS02370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY55_RS02375	COG1116	anion transmembrane transporter activity
GPY55_RS02380	COG0351	phosphomethylpyrimidine kinase
GPY55_RS02390	COG0312	modulator of DNA gyrase
GPY55_RS02395	COG0312	modulator of DNA gyrase
GPY55_RS02400	COG1901	pseudouridine methyltransferase
GPY55_RS02460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY55_RS02470	COG0584	glycerophosphoryl diester phosphodiesterase
GPY55_RS02480	COG0745	RESPONSE REGULATOR receiver
GPY55_RS02500	COG0811	peptide transport
GPY55_RS02505	COG0811	peptide transport
GPY55_RS02510	COG0848	biopolymer transport protein
GPY55_RS02550	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY55_RS02555	COG1121	(ABC) transporter
GPY55_RS02560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY55_RS02575	COG1770	oligopeptidase
GPY55_RS02580	COG2814	Major facilitator Superfamily
GPY55_RS02585	COG0010	Belongs to the arginase family
GPY55_RS02590	COG1166	arginine decarboxylase activity
GPY55_RS02600	COG4067	protein conserved in archaea
GPY55_RS02600	COG0189	ligase activity
GPY55_RS02605	COG0189	ligase activity
GPY55_RS02615	COG0583	DNA-binding transcription factor activity
GPY55_RS02660	COG3706	GGDEF domain
GPY55_RS02665	COG1114	Component of the transport system for branched-chain amino acids
GPY55_RS02690	COG0579	oxidoreductase
GPY55_RS02700	COG3033	Beta-eliminating lyase
GPY55_RS02720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY55_RS02730	COG3145	DNA-N1-methyladenine dioxygenase activity
GPY55_RS02735	COG3706	GGDEF domain
GPY55_RS02740	COG0840	transmembrane signaling receptor activity
GPY55_RS02755	COG3706	GGDEF domain
GPY55_RS02760	COG0415	Belongs to the DNA photolyase family
GPY55_RS02765	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY55_RS02780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY55_RS02780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY55_RS02785	COG1765	OsmC-like protein
GPY55_RS02790	COG0110	maltose O-acetyltransferase activity
GPY55_RS02830	COG1011	Hydrolase
GPY55_RS02845	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY55_RS02850	COG3338	carbonate dehydratase activity
GPY55_RS02855	COG2067	long-chain fatty acid transport protein
GPY55_RS02860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS02865	COG1136	(ABC) transporter
GPY55_RS02865	COG0577	efflux transmembrane transporter activity
GPY55_RS02875	COG3240	lipase activity
GPY55_RS02905	COG1609	Transcriptional regulator
GPY55_RS02910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY55_RS02920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY55_RS02925	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY55_RS02935	COG3842	ATPase activity
GPY55_RS02960	COG2990	Protein conserved in bacteria
GPY55_RS02975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY55_RS02980	COG2866	Carboxypeptidase
GPY55_RS02995	COG0583	DNA-binding transcription factor activity
GPY55_RS03020	COG1760	l-serine dehydratase
GPY55_RS03040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY55_RS03050	COG0741	lytic transglycosylase activity
GPY55_RS03070	COG1815	bacterial-type flagellum-dependent cell motility
GPY55_RS03075	COG1558	bacterial-type flagellum-dependent cell motility
GPY55_RS03080	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY55_RS03085	COG1749	Flagellar hook protein flgE
GPY55_RS03090	COG4787	bacterial-type flagellum-dependent cell motility
GPY55_RS03095	COG4786	Flagellar basal body rod
GPY55_RS03100	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY55_RS03105	COG1706	bacterial-type flagellum-dependent cell motility
GPY55_RS03115	COG4786	Flagellar basal body rod
GPY55_RS03115	COG1256	bacterial-type flagellum assembly
GPY55_RS03120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY55_RS03140	COG1304	FMN binding
GPY55_RS03155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY55_RS03165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY55_RS03170	COG0459	protein refolding
GPY55_RS03185	COG1280	lysine exporter protein (LysE YggA)
GPY55_RS03205	COG1309	transcriptional regulator
GPY55_RS03215	COG0737	Belongs to the 5'-nucleotidase family
GPY55_RS03220	COG2070	2-Nitropropane dioxygenase
GPY55_RS03225	COG3537	Alpha-1,2-mannosidase
GPY55_RS03230	COG3537	Alpha-1,2-mannosidase
GPY55_RS03240	COG3537	Alpha-1,2-mannosidase
GPY55_RS03245	COG3537	Alpha-1,2-mannosidase
GPY55_RS03250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY55_RS03260	COG0583	DNA-binding transcription factor activity
GPY55_RS03275	COG0346	lactoylglutathione lyase activity
GPY55_RS03280	COG1349	DNA-binding transcription factor activity
GPY55_RS03290	COG0753	catalase activity
GPY55_RS03300	COG1335	isochorismatase
GPY55_RS03310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY55_RS03335	COG0583	DNA-binding transcription factor activity
GPY55_RS03350	COG3713	MltA-interacting MipA family protein
GPY55_RS03360	COG3015	lipoprotein NlpE involved in copper resistance
GPY55_RS03370	COG1342	Belongs to the UPF0251 family
GPY55_RS03395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY55_RS03405	COG4948	Mandelate Racemase Muconate Lactonizing
GPY55_RS03415	COG0583	DNA-binding transcription factor activity
GPY55_RS03465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY55_RS03525	COG3842	ATPase activity
GPY55_RS03555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY55_RS03575	COG3706	GGDEF domain
GPY55_RS03595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS03610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY55_RS03615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY55_RS03635	COG0574	Belongs to the PEP-utilizing enzyme family
GPY55_RS03635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY55_RS03640	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY55_RS03645	COG0252	asparaginase activity
GPY55_RS03655	COG0583	DNA-binding transcription factor activity
GPY55_RS03670	COG3122	Protein conserved in bacteria
GPY55_RS03685	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS03695	COG1063	alcohol dehydrogenase
GPY55_RS03700	COG1902	pentaerythritol trinitrate reductase activity
GPY55_RS03715	COG0583	DNA-binding transcription factor activity
GPY55_RS03725	COG0513	Belongs to the DEAD box helicase family
GPY55_RS03755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY55_RS03760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY55_RS03760	COG2207	Transcriptional regulator
GPY55_RS03780	COG3746	phosphate-selective porin O and P
GPY55_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS03840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY55_RS03850	COG0625	glutathione transferase activity
GPY55_RS03860	COG1686	Belongs to the peptidase S11 family
GPY55_RS03885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY55_RS03905	COG1278	Cold shock
GPY55_RS03910	COG1741	Belongs to the pirin family
GPY55_RS03915	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY55_RS03925	COG1846	Transcriptional regulator
GPY55_RS03940	COG2814	Major facilitator Superfamily
GPY55_RS03950	COG0673	inositol 2-dehydrogenase activity
GPY55_RS03955	COG2194	sulfuric ester hydrolase activity
GPY55_RS03960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY55_RS03970	COG2205	protein histidine kinase activity
GPY55_RS03975	COG0745	RESPONSE REGULATOR receiver
GPY55_RS03980	COG4221	oxidoreductase activity
GPY55_RS04000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY55_RS04020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY55_RS04030	COG2814	Major facilitator Superfamily
GPY55_RS04045	COG1418	mRNA catabolic process
GPY55_RS04055	COG0402	S-adenosylhomocysteine deaminase activity
GPY55_RS04060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY55_RS04070	COG2239	Acts as a magnesium transporter
GPY55_RS04075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY55_RS04090	COG0531	amino acid
GPY55_RS04100	COG1522	sequence-specific DNA binding
GPY55_RS04125	COG0784	Response regulator, receiver
GPY55_RS04125	COG2205	protein histidine kinase activity
GPY55_RS04125	COG5002	protein histidine kinase activity
GPY55_RS04130	COG0673	inositol 2-dehydrogenase activity
GPY55_RS04135	COG0534	Mate efflux family protein
GPY55_RS04140	COG2926	Belongs to the UPF0265 family
GPY55_RS04155	COG3132	Protein of unknown function, DUF480
GPY55_RS04160	COG2827	Endonuclease containing a URI domain
GPY55_RS04165	COG1879	ABC-type sugar transport system periplasmic component
GPY55_RS04170	COG2205	protein histidine kinase activity
GPY55_RS04170	COG0784	Response regulator, receiver
GPY55_RS04180	COG1566	PFAM secretion protein HlyD family protein
GPY55_RS04200	COG1522	sequence-specific DNA binding
GPY55_RS04225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY55_RS04230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY55_RS04250	COG0183	Belongs to the thiolase family
GPY55_RS04270	COG3005	denitrification pathway
GPY55_RS04280	COG0243	molybdopterin cofactor binding
GPY55_RS04290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY55_RS04295	COG3850	Histidine kinase
GPY55_RS04300	COG2197	response regulator
GPY55_RS04315	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY55_RS04335	COG0840	transmembrane signaling receptor activity
GPY55_RS04345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY55_RS04355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY55_RS04360	COG2814	Major facilitator Superfamily
GPY55_RS04370	COG0840	transmembrane signaling receptor activity
GPY55_RS04375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY55_RS04380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY55_RS04405	COG2897	thiosulfate sulfurtransferase activity
GPY55_RS04425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY55_RS04435	COG0302	gtp cyclohydrolase
GPY55_RS04440	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY55_RS04450	COG0038	chloride channel
GPY55_RS04465	COG4989	oxidoreductase activity
GPY55_RS04480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY55_RS04480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY55_RS04485	COG0516	GMP reductase activity
GPY55_RS04490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY55_RS04570	COG3474	cytochrome
GPY55_RS04580	COG0789	Transcriptional regulator
GPY55_RS04585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY55_RS04590	COG0384	phenazine biosynthesis protein PhzF
GPY55_RS04600	COG1294	oxidase, subunit
GPY55_RS04605	COG1271	oxidase subunit
GPY55_RS04610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY55_RS04625	COG3264	Mechanosensitive ion channel
GPY55_RS04625	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY55_RS04640	COG3850	Histidine kinase
GPY55_RS04640	COG4999	Histidine kinase
GPY55_RS04640	COG3437	response regulator, receiver
GPY55_RS04640	COG2205	protein histidine kinase activity
GPY55_RS04655	COG1024	Enoyl-CoA hydratase
GPY55_RS04660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY55_RS04665	COG1960	acyl-CoA dehydrogenase activity
GPY55_RS04675	COG0183	Belongs to the thiolase family
GPY55_RS04685	COG1960	acyl-CoA dehydrogenase activity
GPY55_RS04690	COG1024	Enoyl-CoA hydratase
GPY55_RS04715	COG3706	GGDEF domain
GPY55_RS04720	COG1309	transcriptional regulator
GPY55_RS04725	COG1012	belongs to the aldehyde dehydrogenase family
GPY55_RS04745	COG4175	Glycine betaine
GPY55_RS04745	COG0517	IMP dehydrogenase activity
GPY55_RS04760	COG0330	HflC and HflK could
GPY55_RS04770	COG3300	MHYT domain
GPY55_RS04770	COG5001	Diguanylate cyclase
GPY55_RS04790	COG0784	Response regulator, receiver
GPY55_RS04790	COG2205	protein histidine kinase activity
GPY55_RS04850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY55_RS04855	COG5001	Diguanylate cyclase
GPY55_RS04860	COG1869	D-ribose catabolic process
GPY55_RS04865	COG1129	ABC transporter
GPY55_RS04870	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY55_RS04875	COG1879	ABC-type sugar transport system periplasmic component
GPY55_RS04880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY55_RS04885	COG1609	Transcriptional regulator
GPY55_RS04900	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY55_RS04910	COG4607	ABC-type enterochelin transport system periplasmic component
GPY55_RS04915	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY55_RS04920	COG4605	iron ion homeostasis
GPY55_RS04925	COG4604	ABC transporter, ATP-binding protein
GPY55_RS04930	COG0789	Transcriptional regulator
GPY55_RS04945	COG4206	TonB-dependent receptor
GPY55_RS04980	COG1289	transmembrane transporter activity
GPY55_RS04985	COG0210	DNA helicase
GPY55_RS04990	COG1803	Methylglyoxal synthase
GPY55_RS04995	COG1879	ABC-type sugar transport system periplasmic component
GPY55_RS05000	COG0784	Response regulator, receiver
GPY55_RS05000	COG2198	Histidine kinase
GPY55_RS05000	COG2205	protein histidine kinase activity
GPY55_RS05015	COG0745	RESPONSE REGULATOR receiver
GPY55_RS05020	COG3119	arylsulfatase activity
GPY55_RS05025	COG3119	arylsulfatase activity
GPY55_RS05040	COG3119	arylsulfatase activity
GPY55_RS05045	COG0641	radical SAM
GPY55_RS05050	COG0714	Associated with various cellular activities
GPY55_RS05080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY55_RS05080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY55_RS05085	COG0583	DNA-binding transcription factor activity
GPY55_RS05090	COG1597	lipid kinase activity
GPY55_RS05095	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY55_RS05115	COG0641	radical SAM
GPY55_RS05145	COG0501	Belongs to the peptidase M48B family
GPY55_RS05150	COG1704	LemA family
GPY55_RS05155	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY55_RS05165	COG1214	PFAM Peptidase M22, glycoprotease
GPY55_RS05165	COG0456	acetyltransferase
GPY55_RS05185	COG2076	Multidrug Resistance protein
GPY55_RS05215	COG0471	metal ion transport
GPY55_RS05220	COG3290	protein histidine kinase activity
GPY55_RS05225	COG4565	transcriptional regulatory protein
GPY55_RS05235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY55_RS05235	COG0069	glutamate synthase activity
GPY55_RS05245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY55_RS05270	COG1902	pentaerythritol trinitrate reductase activity
GPY55_RS05275	COG0346	lactoylglutathione lyase activity
GPY55_RS05295	COG2239	Acts as a magnesium transporter
GPY55_RS05335	COG0242	peptide deformylase activity
GPY55_RS05385	COG2176	DNA-directed DNA polymerase activity
GPY55_RS05390	COG0583	DNA-binding transcription factor activity
GPY55_RS05395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY55_RS05435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY55_RS05435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY55_RS05440	COG0509	glycine decarboxylation via glycine cleavage system
GPY55_RS05445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY55_RS05485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY55_RS05485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY55_RS05485	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY55_RS05490	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY55_RS05495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS05495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS05500	COG1609	Transcriptional regulator
GPY55_RS05520	COG2200	EAL domain
GPY55_RS05520	COG2203	Gaf domain
GPY55_RS05520	COG2199	diguanylate cyclase activity
GPY55_RS05525	COG0765	amino acid transport
GPY55_RS05530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY55_RS05535	COG0765	amino acid transport
GPY55_RS05540	COG1126	abc transporter atp-binding protein
GPY55_RS05545	COG0469	pyruvate kinase activity
GPY55_RS05550	COG2271	Major facilitator Superfamily
GPY55_RS05555	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY55_RS05575	COG1979	alcohol dehydrogenase
GPY55_RS05580	COG2207	Transcriptional regulator
GPY55_RS05595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY55_RS05600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY55_RS05605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY55_RS05635	COG1196	nuclear chromosome segregation
GPY55_RS05650	COG3328	transposase activity
GPY55_RS05935	COG3421	Type III restriction
GPY55_RS05940	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GPY55_RS05955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY55_RS05990	COG0784	Response regulator, receiver
GPY55_RS05990	COG3437	response regulator, receiver
GPY55_RS06000	COG0546	phosphoglycolate phosphatase activity
GPY55_RS06005	COG0840	transmembrane signaling receptor activity
GPY55_RS06015	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY55_RS06020	COG0513	Belongs to the DEAD box helicase family
GPY55_RS06025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY55_RS06040	COG3038	cytochrome b561
GPY55_RS06045	COG2353	YceI-like domain
GPY55_RS06050	COG2116	formate transmembrane transporter activity
GPY55_RS06055	COG0583	DNA-binding transcription factor activity
GPY55_RS06065	COG3593	DNA synthesis involved in DNA repair
GPY55_RS06070	COG0737	Belongs to the 5'-nucleotidase family
GPY55_RS06075	COG0861	Integral membrane protein TerC family
GPY55_RS06090	COG2267	carboxylic ester hydrolase activity
GPY55_RS06095	COG2067	long-chain fatty acid transport protein
GPY55_RS06110	COG2050	protein possibly involved in aromatic compounds catabolism
GPY55_RS06120	COG4533	DNA binding
GPY55_RS06145	COG0484	heat shock protein binding
GPY55_RS06155	COG5001	Diguanylate cyclase
GPY55_RS06155	COG3300	MHYT domain
GPY55_RS06170	COG4181	ATPase activity
GPY55_RS06175	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY55_RS06185	COG1984	allophanate hydrolase subunit 2
GPY55_RS06190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY55_RS06195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY55_RS06200	COG5001	Diguanylate cyclase
GPY55_RS06200	COG3447	MASE1 domain protein
GPY55_RS06200	COG5002	protein histidine kinase activity
GPY55_RS06205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY55_RS06215	COG4771	TonB-dependent receptor
GPY55_RS06215	COG1629	transport
GPY55_RS06220	COG0583	DNA-binding transcription factor activity
GPY55_RS06225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY55_RS06225	COG1042	CoA-binding domain protein
GPY55_RS06225	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY55_RS06235	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY55_RS06245	COG0023	Translation Initiation Factor
GPY55_RS06265	COG0583	DNA-binding transcription factor activity
GPY55_RS06280	COG3140	Belongs to the UPF0181 family
GPY55_RS06305	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY55_RS06310	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY55_RS06325	COG0745	RESPONSE REGULATOR receiver
GPY55_RS06325	COG3706	GGDEF domain
GPY55_RS06335	COG5001	Diguanylate cyclase
GPY55_RS06335	COG3706	GGDEF domain
GPY55_RS06335	COG2203	Gaf domain
GPY55_RS06335	COG4251	negative regulation of phosphorylation
GPY55_RS06345	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY55_RS06350	COG4149	molybdate abc transporter
GPY55_RS06355	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY55_RS06360	COG1492	cobalamin metabolic process
GPY55_RS06365	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY55_RS06375	COG4067	protein conserved in archaea
GPY55_RS06375	COG0189	ligase activity
GPY55_RS06395	COG0534	Mate efflux family protein
GPY55_RS06400	COG0602	queuosine metabolic process
GPY55_RS06405	COG1328	CTP reductase activity
GPY55_RS06420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY55_RS06450	COG0243	molybdopterin cofactor binding
GPY55_RS06460	COG0583	DNA-binding transcription factor activity
GPY55_RS06465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY55_RS06475	COG2197	response regulator
GPY55_RS06480	COG3851	Histidine kinase
GPY55_RS06485	COG2271	Major facilitator Superfamily
GPY55_RS06510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY55_RS06515	COG3118	belongs to the thioredoxin family
GPY55_RS06520	COG2814	Major facilitator Superfamily
GPY55_RS06530	COG0534	Mate efflux family protein
GPY55_RS06560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY55_RS06580	COG2116	formate transmembrane transporter activity
GPY55_RS06585	COG2146	nitrite reductase [NAD(P)H] activity
GPY55_RS06590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY55_RS06595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY55_RS06645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY55_RS06645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY55_RS06685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY55_RS06705	COG0277	FAD linked oxidase domain protein
GPY55_RS06710	COG0583	DNA-binding transcription factor activity
GPY55_RS06730	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY55_RS06745	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY55_RS06760	COG1288	antiporter activity
GPY55_RS06770	COG0671	phosphoesterase, PA-phosphatase related
GPY55_RS06785	COG2962	Rard protein
GPY55_RS06805	COG0784	Response regulator, receiver
GPY55_RS06805	COG0835	chemotaxis
GPY55_RS06830	COG2197	response regulator
GPY55_RS06840	COG3706	GGDEF domain
GPY55_RS06860	COG3300	MHYT domain
GPY55_RS06860	COG5001	Diguanylate cyclase
GPY55_RS06875	COG0583	DNA-binding transcription factor activity
GPY55_RS06890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY55_RS06920	COG3328	transposase activity
GPY55_RS06925	COG2814	Major facilitator Superfamily
GPY55_RS06935	COG3040	lipid binding
GPY55_RS06945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY55_RS06960	COG0420	3'-5' exonuclease activity
GPY55_RS06975	COG3501	Rhs element vgr protein
GPY55_RS07030	COG0631	protein serine/threonine phosphatase activity
GPY55_RS07065	COG0515	serine threonine protein kinase
GPY55_RS07065	COG2815	serine threonine protein kinase
GPY55_RS07120	COG2146	nitrite reductase [NAD(P)H] activity
GPY55_RS07120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY55_RS07125	COG1116	anion transmembrane transporter activity
GPY55_RS07130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY55_RS07135	COG1116	anion transmembrane transporter activity
GPY55_RS07135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY55_RS07145	COG3707	response regulator
GPY55_RS07170	COG0243	molybdopterin cofactor binding
GPY55_RS07175	COG0456	acetyltransferase
GPY55_RS07180	COG0814	amino acid
GPY55_RS07190	COG0745	RESPONSE REGULATOR receiver
GPY55_RS07190	COG3706	GGDEF domain
GPY55_RS07210	COG1785	Belongs to the alkaline phosphatase family
GPY55_RS07225	COG0745	RESPONSE REGULATOR receiver
GPY55_RS07255	COG2847	Copper chaperone PCu(A)C
GPY55_RS07260	COG0443	Heat shock 70 kDa protein
GPY55_RS07295	COG0625	glutathione transferase activity
GPY55_RS07310	COG4160	amino acid transport
GPY55_RS07315	COG4215	(ABC) transporter
GPY55_RS07320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY55_RS07325	COG1126	abc transporter atp-binding protein
GPY55_RS07355	COG1902	pentaerythritol trinitrate reductase activity
GPY55_RS07370	COG0109	protoheme IX farnesyltransferase activity
GPY55_RS07375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY55_RS07380	COG1845	cytochrome c oxidase, subunit III
GPY55_RS07385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY55_RS07390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY55_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS07405	COG1024	Enoyl-CoA hydratase
GPY55_RS07410	COG1024	Enoyl-CoA hydratase
GPY55_RS07425	COG0183	Belongs to the thiolase family
GPY55_RS07435	COG1960	acyl-CoA dehydrogenase activity
GPY55_RS07440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY55_RS07445	COG1024	Enoyl-CoA hydratase
GPY55_RS07455	COG5413	integral membrane protein
GPY55_RS07470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY55_RS07480	COG5001	Diguanylate cyclase
GPY55_RS07485	COG0513	Belongs to the DEAD box helicase family
GPY55_RS07490	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY55_RS07505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY55_RS07520	COG0582	viral genome integration into host DNA
GPY55_RS07590	COG0641	radical SAM
GPY55_RS07615	COG0840	transmembrane signaling receptor activity
GPY55_RS07620	COG1119	ATPase activity
GPY55_RS07625	COG2200	EAL domain
GPY55_RS07645	COG0513	Belongs to the DEAD box helicase family
GPY55_RS07650	COG0523	cobalamin synthesis protein
GPY55_RS07660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY55_RS07670	COG0133	tryptophan synthase activity
GPY55_RS07675	COG4628	conserved protein (DUF2132)
GPY55_RS07680	COG0513	Belongs to the DEAD box helicase family
GPY55_RS07685	COG3530	Putative quorum-sensing-regulated virulence factor
GPY55_RS07710	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY55_RS07715	COG3186	Phenylalanine-4-hydroxylase
GPY55_RS07720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY55_RS07725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY55_RS07765	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY55_RS07770	COG1454	alcohol dehydrogenase
GPY55_RS07775	COG2133	pyrroloquinoline quinone binding
GPY55_RS07785	COG0783	Belongs to the Dps family
GPY55_RS07800	COG0577	efflux transmembrane transporter activity
GPY55_RS07800	COG1136	(ABC) transporter
GPY55_RS07820	COG2199	diguanylate cyclase activity
GPY55_RS07835	COG3036	rescue of stalled ribosome
GPY55_RS07840	COG1278	Cold shock
GPY55_RS07875	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY55_RS07880	COG0109	protoheme IX farnesyltransferase activity
GPY55_RS07885	COG1612	heme a metabolic process
GPY55_RS07910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY55_RS07920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY55_RS07925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY55_RS07935	COG1280	lysine exporter protein (LysE YggA)
GPY55_RS07940	COG2207	Transcriptional regulator
GPY55_RS07970	COG0697	spore germination
GPY55_RS07995	COG2814	Major facilitator Superfamily
GPY55_RS08000	COG0583	DNA-binding transcription factor activity
GPY55_RS08005	COG5001	Diguanylate cyclase
GPY55_RS08010	COG0739	heme binding
GPY55_RS08050	COG0814	amino acid
GPY55_RS08070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY55_RS08075	COG1072	(Pantothenic acid kinase))
GPY55_RS08085	COG1063	alcohol dehydrogenase
GPY55_RS08090	COG2213	PTS system mannitol-specific
GPY55_RS08095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS08115	COG0798	PFAM Bile acid sodium symporter
GPY55_RS08125	COG1881	PFAM PEBP family protein
GPY55_RS08135	COG2706	6-phosphogluconolactonase activity
GPY55_RS08150	COG1131	(ABC) transporter
GPY55_RS08155	COG0842	Transport permease protein
GPY55_RS08170	COG3383	formate dehydrogenase (NAD+) activity
GPY55_RS08215	COG2199	diguanylate cyclase activity
GPY55_RS08215	COG2203	Gaf domain
GPY55_RS08225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY55_RS08235	COG2067	long-chain fatty acid transport protein
GPY55_RS08245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS08260	COG1505	serine-type exopeptidase activity
GPY55_RS08265	COG0488	(ABC) transporter
GPY55_RS08270	COG0589	response to stress
GPY55_RS08275	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY55_RS08295	COG0366	Alpha amylase catalytic
GPY55_RS08305	COG4934	collagen metabolic process
GPY55_RS08320	COG0641	radical SAM
GPY55_RS08340	COG0583	DNA-binding transcription factor activity
GPY55_RS08350	COG0783	Belongs to the Dps family
GPY55_RS08355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY55_RS08380	COG3344	reverse transcriptase
GPY55_RS08385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY55_RS08385	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GPY55_RS08395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY55_RS08400	COG0784	Response regulator, receiver
GPY55_RS08400	COG0835	chemotaxis
GPY55_RS08410	COG0748	coenzyme F420 binding
GPY55_RS08415	COG3721	Heme iron utilization protein
GPY55_RS08425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY55_RS08430	COG0811	peptide transport
GPY55_RS08435	COG0848	biopolymer transport protein
GPY55_RS08445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY55_RS08450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY55_RS08490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY55_RS08495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY55_RS08500	COG3217	Mosc domain protein beta barrel domain protein
GPY55_RS08500	COG0633	Ferredoxin
GPY55_RS08500	COG0633	Ferredoxin
GPY55_RS08500	COG3217	Mosc domain protein beta barrel domain protein
GPY55_RS08510	COG0401	homolog of Blt101
GPY55_RS08520	COG0418	dihydroorotase activity
GPY55_RS09015	COG3263	regulation of cellular component size
GPY55_RS09025	COG4232	protein-disulfide reductase activity
GPY55_RS09030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY55_RS09035	COG1027	Aspartate ammonia-lyase
GPY55_RS09040	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY55_RS09045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY55_RS09055	COG2205	protein histidine kinase activity
GPY55_RS09060	COG0745	RESPONSE REGULATOR receiver
GPY55_RS09065	COG3678	ATP-independent chaperone mediated protein folding
GPY55_RS09075	COG0205	6-phosphofructokinase activity
GPY55_RS09080	COG0534	Mate efflux family protein
GPY55_RS09085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY55_RS09090	COG0459	protein refolding
GPY55_RS09105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY55_RS09120	COG1509	lysine 2,3-aminomutase activity
GPY55_RS09125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY55_RS09135	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY55_RS09140	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY55_RS09145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY55_RS09150	COG1053	succinate dehydrogenase
GPY55_RS09160	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY55_RS09180	COG4942	peptidase
GPY55_RS09185	COG1045	serine acetyltransferase
GPY55_RS09190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY55_RS09195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY55_RS09200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY55_RS09205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY55_RS09220	COG0471	metal ion transport
GPY55_RS09225	COG0688	phosphatidylethanolamine metabolic process
GPY55_RS09230	COG1162	GTPase activity
GPY55_RS09235	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY55_RS09305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY55_RS09310	COG0802	atpase or kinase
GPY55_RS09320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY55_RS09325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY55_RS09335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY55_RS09340	COG0330	HflC and HflK could
GPY55_RS09345	COG0330	HflC and HflK could
GPY55_RS09350	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY55_RS09355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY55_RS09365	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY55_RS09370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY55_RS09370	COG1017	nitric oxide dioxygenase activity
GPY55_RS09375	COG1959	2 iron, 2 sulfur cluster binding
GPY55_RS09380	COG0557	exoribonuclease II activity
GPY55_RS09385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY55_RS09390	COG0546	phosphoglycolate phosphatase activity
GPY55_RS09395	COG0180	Tryptophanyl-tRNA synthetase
GPY55_RS09425	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY55_RS09430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY55_RS09440	COG1012	belongs to the aldehyde dehydrogenase family
GPY55_RS09450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY55_RS09455	COG3954	Phosphoribulokinase
GPY55_RS09460	COG3089	Belongs to the UPF0270 family
GPY55_RS09465	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY55_RS09475	COG0488	(ABC) transporter
GPY55_RS09485	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY55_RS09500	COG1047	Peptidyl-prolyl cis-trans
GPY55_RS09510	COG1446	asparaginase
GPY55_RS09515	COG2900	Belongs to the SlyX family
GPY55_RS09525	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY55_RS09530	COG2964	Protein conserved in bacteria
GPY55_RS09535	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY55_RS09540	COG2923	Belongs to the DsrF TusC family
GPY55_RS09555	COG0049	tRNA binding
GPY55_RS09560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY55_RS09565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY55_RS09570	COG2906	2 iron, 2 sulfur cluster binding
GPY55_RS09580	COG0281	malic enzyme
GPY55_RS09590	COG0626	cystathionine gamma-synthase activity
GPY55_RS09595	COG0460	homoserine dehydrogenase
GPY55_RS09595	COG0527	aspartate kinase activity
GPY55_RS09600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY55_RS09610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY55_RS09615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY55_RS09620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY55_RS09625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY55_RS09630	COG0137	argininosuccinate synthase activity
GPY55_RS09635	COG0165	Argininosuccinate lyase
GPY55_RS09635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY55_RS09650	COG0678	peroxiredoxin activity
GPY55_RS09650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY55_RS09660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY55_RS09690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY55_RS09695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY55_RS09705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY55_RS09710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY55_RS09715	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY55_RS09720	COG2965	DNA replication, synthesis of RNA primer
GPY55_RS09730	COG0359	binds to the 23S rRNA
GPY55_RS09740	COG0305	Participates in initiation and elongation during chromosome replication
GPY55_RS09745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY55_RS09755	COG0432	Pfam Uncharacterised protein family UPF0047
GPY55_RS09760	COG0166	Belongs to the GPI family
GPY55_RS09770	COG0735	belongs to the Fur family
GPY55_RS09780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY55_RS09805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY55_RS09810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY55_RS09815	COG0175	sulfate reduction
GPY55_RS09870	COG3335	DDE superfamily endonuclease
GPY55_RS09885	COG0646	methionine synthase
GPY55_RS09885	COG1410	methionine synthase
GPY55_RS09890	COG0527	aspartate kinase activity
GPY55_RS09895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY55_RS09905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY55_RS09920	COG0629	single-stranded DNA binding
GPY55_RS09925	COG2200	EAL domain
GPY55_RS09925	COG2199	diguanylate cyclase activity
GPY55_RS09950	COG3409	Peptidoglycan-binding domain 1 protein
GPY55_RS09950	COG3267	Type II secretory pathway component ExeA
GPY55_RS09960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY55_RS09965	COG1459	type II secretion system
GPY55_RS10010	COG1077	Cell shape determining protein MreB Mrl
GPY55_RS10015	COG1792	Involved in formation and maintenance of cell shape
GPY55_RS10020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY55_RS10025	COG0424	maF-like protein
GPY55_RS10030	COG1530	ribonuclease E activity
GPY55_RS10035	COG3164	Protein of unknown function
GPY55_RS10040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY55_RS10045	COG0312	modulator of DNA gyrase
GPY55_RS10050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY55_RS10055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY55_RS10070	COG0564	pseudouridine synthase activity
GPY55_RS10075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY55_RS10080	COG3028	Belongs to the UPF0307 family
GPY55_RS10085	COG0312	modulator of DNA gyrase
GPY55_RS10090	COG2239	Acts as a magnesium transporter
GPY55_RS10095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS10100	COG1660	Displays ATPase and GTPase activities
GPY55_RS10105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS10110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY55_RS10120	COG1137	ATPase activity
GPY55_RS10125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY55_RS10135	COG0517	IMP dehydrogenase activity
GPY55_RS10135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY55_RS10145	COG1127	ABC transporter
GPY55_RS10150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY55_RS10155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY55_RS10160	COG2854	intermembrane phospholipid transfer
GPY55_RS10170	COG5007	Belongs to the BolA IbaG family
GPY55_RS10175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY55_RS10180	COG0204	Acyl-transferase
GPY55_RS10185	COG0251	oxidation-reduction process
GPY55_RS10190	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY55_RS10195	COG0540	Belongs to the ATCase OTCase family
GPY55_RS10205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY55_RS10210	COG2235	arginine
GPY55_RS10240	COG0525	valine-tRNA ligase activity
GPY55_RS10245	COG2927	DNA polymerase III (CHI subunit)
GPY55_RS10250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY55_RS10255	COG0795	lipopolysaccharide-transporting ATPase activity
GPY55_RS10260	COG0795	lipopolysaccharide-transporting ATPase activity
GPY55_RS10270	COG4325	translation initiation factor activity
GPY55_RS10275	COG4221	oxidoreductase activity
GPY55_RS10285	COG0726	polysaccharide deacetylase
GPY55_RS10290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY55_RS10295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY55_RS10300	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY55_RS10305	COG1486	melibiose metabolic process
GPY55_RS10310	COG3394	polysaccharide catabolic process
GPY55_RS10320	COG3437	response regulator, receiver
GPY55_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
GPY55_RS10440	COG0741	lytic transglycosylase activity
GPY55_RS10445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY55_RS10455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY55_RS10465	COG2066	Belongs to the glutaminase family
GPY55_RS10470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY55_RS10475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY55_RS10485	COG1872	DUF167
GPY55_RS10490	COG0762	integral membrane protein
GPY55_RS10495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY55_RS10500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY55_RS10515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY55_RS10520	COG1678	Uncharacterized ACR, COG1678
GPY55_RS10525	COG0189	ligase activity
GPY55_RS10530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY55_RS10535	COG2356	endonuclease I
GPY55_RS10540	COG3091	SprT-like family
GPY55_RS10550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY55_RS10560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY55_RS10565	COG0583	DNA-binding transcription factor activity
GPY55_RS10570	COG4771	TonB-dependent receptor
GPY55_RS10575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY55_RS10580	COG0126	phosphoglycerate kinase activity
GPY55_RS10585	COG0191	fructose-bisphosphate aldolase activity
GPY55_RS10590	COG0668	transmembrane transport
GPY55_RS10595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY55_RS10605	COG0583	DNA-binding transcription factor activity
GPY55_RS10615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY55_RS10620	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY55_RS10625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY55_RS10635	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY55_RS10645	COG3079	Belongs to the UPF0149 family
GPY55_RS10650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY55_RS10655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY55_RS10670	COG0354	folic acid binding
GPY55_RS10675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY55_RS10685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY55_RS10695	COG1595	DNA-templated transcription, initiation
GPY55_RS10700	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY55_RS10710	COG3086	response to oxidative stress
GPY55_RS10715	COG0481	GTPase activity
GPY55_RS10720	COG0681	Belongs to the peptidase S26 family
GPY55_RS10725	COG0571	ribonuclease III activity
GPY55_RS10730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY55_RS10735	COG1381	Involved in DNA repair and RecF pathway recombination
GPY55_RS10740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY55_RS10745	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY55_RS10755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY55_RS10765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY55_RS10770	COG3956	TIGRFAM MazG family protein
GPY55_RS10775	COG0504	CTP synthase activity
GPY55_RS10780	COG0148	phosphopyruvate hydratase activity
GPY55_RS10785	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY55_RS10790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY55_RS10795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY55_RS10800	COG0585	pseudouridine synthase activity
GPY55_RS10805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY55_RS10810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY55_RS10825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY55_RS10830	COG1546	Belongs to the CinA family
GPY55_RS10835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY55_RS10840	COG2137	regulation of response to DNA damage stimulus
GPY55_RS10845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY55_RS10850	COG0527	aspartate kinase activity
GPY55_RS10910	COG3630	sodium ion export across plasma membrane
GPY55_RS10915	COG0511	ligase activity, forming carbon-carbon bonds
GPY55_RS10915	COG5016	pyruvate
GPY55_RS10920	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY55_RS10925	COG1063	alcohol dehydrogenase
GPY55_RS10930	COG1238	metal cluster binding
GPY55_RS10935	COG0612	Peptidase, M16
GPY55_RS10940	COG2918	glutathione biosynthetic process
GPY55_RS10950	COG1854	S-ribosylhomocysteine lyase activity
GPY55_RS10955	COG4536	flavin adenine dinucleotide binding
GPY55_RS10960	COG4137	Cytochrome C assembly protein
GPY55_RS10965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY55_RS10970	COG0228	four-way junction DNA binding
GPY55_RS10975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY55_RS10980	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY55_RS10985	COG0335	large ribosomal subunit rRNA binding
GPY55_RS10990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY55_RS10995	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY55_RS11000	COG0237	dephospho-CoA kinase activity
GPY55_RS11010	COG1459	type II secretion system
GPY55_RS11015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY55_RS11020	COG4969	Belongs to the N-Me-Phe pilin family
GPY55_RS11025	COG0157	Belongs to the NadC ModD family
GPY55_RS11035	COG2186	Transcriptional regulator
GPY55_RS11040	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY55_RS11045	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY55_RS11050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY55_RS11065	COG0288	reversible hydration of carbon dioxide
GPY55_RS11070	COG0659	secondary active sulfate transmembrane transporter activity
GPY55_RS11080	COG1131	(ABC) transporter
GPY55_RS11085	COG0842	Transport permease protein
GPY55_RS11090	COG1560	Kdo2-lipid A biosynthetic process
GPY55_RS11100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY55_RS11105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY55_RS11110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY55_RS11125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY55_RS11135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY55_RS11140	COG1489	DNA binding
GPY55_RS11145	COG1643	Atp-dependent helicase
GPY55_RS11150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY55_RS11155	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY55_RS11160	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY55_RS11165	COG3112	Uncharacterised protein family (UPF0231)
GPY55_RS11175	COG0004	ammonium transporteR
GPY55_RS11180	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY55_RS11190	COG3842	ATPase activity
GPY55_RS11195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY55_RS11210	COG2971	BadF BadG BcrA BcrD
GPY55_RS11220	COG4608	Belongs to the ABC transporter superfamily
GPY55_RS11225	COG0444	Belongs to the ABC transporter superfamily
GPY55_RS11230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY55_RS11240	COG0747	negative chemotaxis
GPY55_RS11245	COG2205	protein histidine kinase activity
GPY55_RS11245	COG2198	Histidine kinase
GPY55_RS11245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY55_RS11245	COG0784	Response regulator, receiver
GPY55_RS11250	COG2813	Specifically methylates the guanine in position
GPY55_RS11255	COG0628	permease
GPY55_RS11260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY55_RS11265	COG0316	Belongs to the HesB IscA family
GPY55_RS11275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY55_RS11280	COG0739	heme binding
GPY55_RS11285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY55_RS11290	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY55_RS11295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY55_RS11295	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY55_RS11320	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY55_RS11325	COG2252	PERMEase
GPY55_RS11330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY55_RS11345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY55_RS11350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY55_RS11355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY55_RS11360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY55_RS11360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY55_RS11380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY55_RS11385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY55_RS11390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY55_RS11395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY55_RS11400	COG0142	geranyltranstransferase activity
GPY55_RS11405	COG1722	exodeoxyribonuclease VII activity
GPY55_RS11410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY55_RS11415	COG2885	chlorophyll binding
GPY55_RS11420	COG0301	tRNA thio-modification
GPY55_RS11420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY55_RS11425	COG0583	DNA-binding transcription factor activity
GPY55_RS11435	COG2363	Small membrane protein
GPY55_RS11440	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GPY55_RS11450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY55_RS11455	COG1611	Belongs to the LOG family
GPY55_RS11460	COG3706	GGDEF domain
GPY55_RS11470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY55_RS11470	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY55_RS11480	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY55_RS11485	COG1464	Belongs to the NlpA lipoprotein family
GPY55_RS11490	COG2011	ABC-type metal ion transport system permease component
GPY55_RS11495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY55_RS11505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY55_RS11515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY55_RS11515	COG1263	PTS System
GPY55_RS11520	COG0366	Alpha amylase catalytic
GPY55_RS11535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY55_RS11540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY55_RS11545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY55_RS11550	COG0321	lipoyl(octanoyl) transferase activity
GPY55_RS11555	COG2921	Belongs to the UPF0250 family
GPY55_RS11560	COG1686	Belongs to the peptidase S11 family
GPY55_RS11565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY55_RS11570	COG0772	Belongs to the SEDS family
GPY55_RS11575	COG0768	penicillin binding
GPY55_RS11580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY55_RS11585	COG0799	negative regulation of ribosome biogenesis
GPY55_RS11590	COG1466	dna polymerase III delta subunit
GPY55_RS11595	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY55_RS11600	COG0495	leucyl-tRNA aminoacylation
GPY55_RS11605	COG2888	peptidyl-tyrosine sulfation
GPY55_RS11610	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY55_RS11615	COG4535	Mg2 and Co2 transporter CorC
GPY55_RS11620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY55_RS11625	COG1702	phosphate starvation-inducible protein PhoH
GPY55_RS11630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY55_RS11640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY55_RS11750	COG0012	GTP binding
GPY55_RS11755	COG0193	aminoacyl-tRNA hydrolase activity
GPY55_RS11760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY55_RS11765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY55_RS11770	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY55_RS11775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY55_RS11780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY55_RS11785	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY55_RS11790	COG3094	Invasion gene expression up-regulator, SirB
GPY55_RS11795	COG2912	Transglutaminase-like superfamily
GPY55_RS11800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY55_RS11805	COG0737	Belongs to the 5'-nucleotidase family
GPY55_RS11815	COG1187	pseudouridine synthase activity
GPY55_RS11820	COG2840	Smr protein MutS2
GPY55_RS11860	COG2608	mercury ion transmembrane transporter activity
GPY55_RS11860	COG2217	Heavy metal translocating P-type atpase
GPY55_RS11875	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY55_RS11880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY55_RS11940	COG0784	Response regulator, receiver
GPY55_RS11940	COG0835	chemotaxis
GPY55_RS11945	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY55_RS11950	COG1815	bacterial-type flagellum-dependent cell motility
GPY55_RS11955	COG1558	bacterial-type flagellum-dependent cell motility
GPY55_RS11960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY55_RS11965	COG1749	Flagellar hook protein flgE
GPY55_RS11975	COG4787	bacterial-type flagellum-dependent cell motility
GPY55_RS11980	COG4786	Flagellar basal body rod
GPY55_RS11985	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY55_RS11990	COG1706	bacterial-type flagellum-dependent cell motility
GPY55_RS11995	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY55_RS11995	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY55_RS12005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY55_RS12015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY55_RS12025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY55_RS12030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY55_RS12040	COG2190	(PTS) system
GPY55_RS12045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY55_RS12050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS12060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY55_RS12065	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY55_RS12070	COG3115	cell septum assembly
GPY55_RS12075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY55_RS12100	COG0330	HflC and HflK could
GPY55_RS12105	COG2194	sulfuric ester hydrolase activity
GPY55_RS12125	COG1215	transferase activity, transferring glycosyl groups
GPY55_RS12130	COG1215	transferase activity, transferring glycosyl groups
GPY55_RS12135	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GPY55_RS12140	COG3118	belongs to the thioredoxin family
GPY55_RS12140	COG0457	Tetratricopeptide repeat
GPY55_RS12145	COG3118	belongs to the thioredoxin family
GPY55_RS12155	COG0300	oxidoreductase activity
GPY55_RS12160	COG1090	epimerase
GPY55_RS12190	COG0622	Phosphoesterase
GPY55_RS12210	COG3710	Transcriptional regulator
GPY55_RS12215	COG0326	Molecular chaperone. Has ATPase activity
GPY55_RS12220	COG0563	adenylate kinase activity
GPY55_RS12225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY55_RS12230	COG3104	oligopeptide transport
GPY55_RS12235	COG0250	Participates in transcription elongation, termination and antitermination
GPY55_RS12240	COG0367	asparagine synthase
GPY55_RS12250	COG1940	carbohydrate kinase activity
GPY55_RS12250	COG1846	Transcriptional regulator
GPY55_RS12255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY55_RS12265	COG1263	PTS System
GPY55_RS12265	COG2190	(PTS) system
GPY55_RS12265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY55_RS12270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY55_RS12275	COG0735	belongs to the Fur family
GPY55_RS12285	COG0716	FMN binding
GPY55_RS12295	COG0596	Alpha beta hydrolase
GPY55_RS12300	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY55_RS12305	COG0033	Phosphoglucomutase
GPY55_RS12315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY55_RS12325	COG2009	succinate dehydrogenase
GPY55_RS12330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY55_RS12335	COG1053	succinate dehydrogenase
GPY55_RS12340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY55_RS12345	COG0567	Dehydrogenase, E1 component
GPY55_RS12350	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY55_RS12355	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY55_RS12365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY55_RS12370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY55_RS12375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY55_RS12380	COG2233	PERMEase
GPY55_RS12400	COG1393	Belongs to the ArsC family
GPY55_RS12405	COG4783	chaperone-mediated protein folding
GPY55_RS12420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY55_RS12425	COG2716	regulation of RNA biosynthetic process
GPY55_RS12430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY55_RS12450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY55_RS12455	COG1393	Belongs to the ArsC family
GPY55_RS12485	COG2837	iron assimilation
GPY55_RS12500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY55_RS12505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY55_RS12510	COG1334	flagellar protein FlaG
GPY55_RS12515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY55_RS12525	COG1516	flagellar protein fliS
GPY55_RS12535	COG4191	Histidine kinase
GPY55_RS12540	COG2204	response regulator
GPY55_RS12545	COG1677	Flagellar hook-basal body complex protein FliE
GPY55_RS12555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY55_RS12605	COG1987	bacterial-type flagellum assembly
GPY55_RS12610	COG1684	flagellar biosynthetic protein fliR
GPY55_RS12630	COG0455	bacterial-type flagellum organization
GPY55_RS12645	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY55_RS12650	COG2198	Histidine kinase
GPY55_RS12650	COG0643	Histidine kinase
GPY55_RS12655	COG2201	protein-glutamate methylesterase activity
GPY55_RS12660	COG1192	Involved in chromosome partitioning
GPY55_RS12670	COG0835	chemotaxis
GPY55_RS12680	COG4133	protoheme IX ABC transporter activity
GPY55_RS12685	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY55_RS12690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY55_RS12695	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY55_RS12700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY55_RS12705	COG1138	Cytochrome C-type biogenesis protein
GPY55_RS12710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY55_RS12725	COG2853	Lipoprotein
GPY55_RS12735	COG2067	long-chain fatty acid transport protein
GPY55_RS12750	COG0183	Belongs to the thiolase family
GPY55_RS12755	COG1024	Enoyl-CoA hydratase
GPY55_RS12755	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY55_RS12770	COG2062	phosphohistidine phosphatase, SixA
GPY55_RS12775	COG2840	Smr protein MutS2
GPY55_RS12780	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY55_RS12790	COG2860	membrane
GPY55_RS12800	COG3101	peptidyl-lysine hydroxylation
GPY55_RS12815	COG0431	NADPH-dependent FMN reductase
GPY55_RS12820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY55_RS12820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY55_RS12825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY55_RS12830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY55_RS12835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY55_RS12845	COG0101	tRNA pseudouridine synthase activity
GPY55_RS12850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY55_RS12855	COG0285	dihydrofolate synthase activity
GPY55_RS12860	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY55_RS12865	COG1286	toxin biosynthetic process
GPY55_RS12870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY55_RS12875	COG0583	DNA-binding transcription factor activity
GPY55_RS12880	COG0745	RESPONSE REGULATOR receiver
GPY55_RS12890	COG2832	Protein of unknown function (DUF454)
GPY55_RS12895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY55_RS12905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY55_RS12910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY55_RS12915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY55_RS12920	COG0814	amino acid
GPY55_RS12925	COG0251	oxidation-reduction process
GPY55_RS12930	COG3681	Belongs to the UPF0597 family
GPY55_RS12945	COG2261	transglycosylase associated protein
GPY55_RS12950	COG2983	Belongs to the UPF0260 family
GPY55_RS12955	COG0668	transmembrane transport
GPY55_RS12960	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY55_RS12965	COG0346	lactoylglutathione lyase activity
GPY55_RS12975	COG1785	Belongs to the alkaline phosphatase family
GPY55_RS12995	COG2226	methyltransferase
GPY55_RS13010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY55_RS13015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY55_RS13025	COG3139	Protein of unknown function (DUF1315)
GPY55_RS13030	COG0252	asparaginase activity
GPY55_RS13035	COG0616	signal peptide processing
GPY55_RS13040	COG1902	pentaerythritol trinitrate reductase activity
GPY55_RS13040	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY55_RS13045	COG0778	Nitroreductase
GPY55_RS13050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY55_RS13070	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY55_RS13080	COG3083	sulfuric ester hydrolase activity
GPY55_RS13085	COG3082	Protein of unknown function (DUF1414)
GPY55_RS13090	COG3081	Nucleoid-associated protein
GPY55_RS13105	COG1757	Na H antiporter
GPY55_RS13110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY55_RS13115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY55_RS13120	COG2095	MarC family integral membrane protein
GPY55_RS13125	COG1454	alcohol dehydrogenase
GPY55_RS13125	COG1012	belongs to the aldehyde dehydrogenase family
GPY55_RS13145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY55_RS13155	COG2056	Na+-H+ antiporter family
GPY55_RS13160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY55_RS13175	COG2885	chlorophyll binding
GPY55_RS13185	COG0346	lactoylglutathione lyase activity
GPY55_RS13190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY55_RS13195	COG4660	Part of a membrane complex involved in electron transport
GPY55_RS13200	COG4659	FMN binding
GPY55_RS13205	COG4658	electron transport chain
GPY55_RS13210	COG4656	Part of a membrane complex involved in electron transport
GPY55_RS13215	COG2878	Part of a membrane complex involved in electron transport
GPY55_RS13220	COG4657	Part of a membrane complex involved in electron transport
GPY55_RS13235	COG0708	Exodeoxyribonuclease III
GPY55_RS13245	COG3923	Primosomal replication protein n
GPY55_RS13250	COG0730	response to heat
GPY55_RS13255	COG1199	ATP-dependent helicase activity
GPY55_RS13260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY55_RS13265	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY55_RS13270	COG1187	pseudouridine synthase activity
GPY55_RS13280	COG1278	Cold shock
GPY55_RS13285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY55_RS13290	COG0542	response to heat
GPY55_RS13300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY55_RS13305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY55_RS13310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY55_RS13320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY55_RS13330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY55_RS13335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY55_RS13340	COG0297	glycogen (starch) synthase activity
GPY55_RS13360	COG3070	regulator of competence-specific genes
GPY55_RS13365	COG1609	Transcriptional regulator
GPY55_RS13370	COG3381	protein complex oligomerization
GPY55_RS13375	COG0745	RESPONSE REGULATOR receiver
GPY55_RS13380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY55_RS13385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY55_RS13390	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY55_RS13395	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY55_RS13400	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY55_RS13420	COG4067	protein conserved in archaea
GPY55_RS13420	COG0189	ligase activity
GPY55_RS13430	COG0500	methyltransferase
GPY55_RS13435	COG4106	trans-aconitate 2-methyltransferase activity
GPY55_RS13440	COG1801	Protein of unknown function DUF72
GPY55_RS13445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY55_RS13450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY55_RS13455	COG0840	transmembrane signaling receptor activity
GPY55_RS13460	COG0632	four-way junction helicase activity
GPY55_RS13465	COG2255	four-way junction helicase activity
GPY55_RS13470	COG1271	oxidase subunit
GPY55_RS13475	COG1294	oxidase, subunit
GPY55_RS13480	COG4890	Cyd operon protein YbgT
GPY55_RS13490	COG0824	Thioesterase
GPY55_RS13495	COG0811	peptide transport
GPY55_RS13510	COG0823	Involved in the tonB-independent uptake of proteins
GPY55_RS13515	COG2885	chlorophyll binding
GPY55_RS13520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY55_RS13525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY55_RS13530	COG3012	SEC-C Motif Domain Protein
GPY55_RS13530	COG3318	Belongs to the UPF0149 family
GPY55_RS13535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY55_RS13540	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY55_RS13545	COG2186	Transcriptional regulator
GPY55_RS13555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY55_RS13555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY55_RS13560	COG0489	protein tyrosine kinase activity
GPY55_RS13565	COG0572	uridine kinase
GPY55_RS13575	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY55_RS13580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY55_RS13585	COG0659	secondary active sulfate transmembrane transporter activity
GPY55_RS13590	COG1530	ribonuclease E activity
GPY55_RS13595	COG0564	pseudouridine synthase activity
GPY55_RS13600	COG0424	maF-like protein
GPY55_RS13605	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY55_RS13615	COG0416	fatty acid biosynthetic process
GPY55_RS13620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY55_RS13650	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY55_RS13655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY55_RS13665	COG0084	hydrolase, TatD family'
GPY55_RS13670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY55_RS13670	COG1263	PTS System
GPY55_RS13690	COG0733	neurotransmitter:sodium symporter activity
GPY55_RS13705	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY55_RS13710	COG0469	pyruvate kinase activity
GPY55_RS13715	COG1940	carbohydrate kinase activity
GPY55_RS13720	COG0784	Response regulator, receiver
GPY55_RS13720	COG0835	chemotaxis
GPY55_RS13725	COG0587	DNA-directed DNA polymerase activity
GPY55_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS13745	COG0616	signal peptide processing
GPY55_RS13750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY55_RS13755	COG0539	negative regulation of cytoplasmic translation
GPY55_RS13765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY55_RS13770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY55_RS13775	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY55_RS13780	COG4166	transmembrane transport
GPY55_RS13795	COG0463	Glycosyl transferase, family 2
GPY55_RS13805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY55_RS13815	COG3008	intermembrane lipid transfer
GPY55_RS13815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY55_RS13820	COG2995	paraquat-inducible protein a
GPY55_RS13825	COG3258	Cytochrome c
GPY55_RS13830	COG2863	cytochrome
GPY55_RS13870	COG4232	protein-disulfide reductase activity
GPY55_RS13875	COG3118	belongs to the thioredoxin family
GPY55_RS13905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS13915	COG0577	efflux transmembrane transporter activity
GPY55_RS13915	COG1136	(ABC) transporter
GPY55_RS13925	COG1136	(ABC) transporter
GPY55_RS13925	COG0577	efflux transmembrane transporter activity
GPY55_RS13930	COG1335	isochorismatase
GPY55_RS13945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY55_RS13950	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY55_RS13975	COG2116	formate transmembrane transporter activity
GPY55_RS13985	COG0390	transport system, permease component
GPY55_RS13990	COG4459	periplasmic nitrate reductase
GPY55_RS13995	COG3005	denitrification pathway
GPY55_RS14000	COG0243	molybdopterin cofactor binding
GPY55_RS14015	COG1227	inorganic diphosphatase activity
GPY55_RS14025	COG4172	Belongs to the ABC transporter superfamily
GPY55_RS14035	COG4171	peptide transport system, permease
GPY55_RS14040	COG4168	peptide transport system, permease
GPY55_RS14050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY55_RS14055	COG1842	Phage shock protein A
GPY55_RS14065	COG1983	PspC domain protein
GPY55_RS14070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS14085	COG2818	Glycosylase
GPY55_RS14090	COG5380	lipid catabolic process
GPY55_RS14095	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY55_RS14100	COG0626	cystathionine gamma-synthase activity
GPY55_RS14110	COG0733	neurotransmitter:sodium symporter activity
GPY55_RS14120	COG0564	pseudouridine synthase activity
GPY55_RS14130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY55_RS14135	COG1151	hydroxylamine reductase activity
GPY55_RS14140	COG3604	Transcriptional regulator
GPY55_RS14155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY55_RS14160	COG4136	ATPase activity
GPY55_RS14165	COG4135	transport system, permease component
GPY55_RS14170	COG4134	Bacterial extracellular solute-binding protein
GPY55_RS14175	COG0398	Pfam SNARE associated Golgi protein
GPY55_RS14185	COG0493	'glutamate synthase
GPY55_RS14210	COG3313	Fe-S protein
GPY55_RS14240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY55_RS14245	COG2205	protein histidine kinase activity
GPY55_RS14250	COG0745	RESPONSE REGULATOR receiver
GPY55_RS14260	COG1061	Type III restriction enzyme res subunit
GPY55_RS14265	COG1187	pseudouridine synthase activity
GPY55_RS14270	COG2814	Major facilitator Superfamily
GPY55_RS14300	COG3005	denitrification pathway
GPY55_RS14305	COG0702	epimerase
GPY55_RS14310	COG0534	Mate efflux family protein
GPY55_RS14315	COG4181	ATPase activity
GPY55_RS14330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY55_RS14345	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY55_RS14350	COG3273	potassium ion transport
GPY55_RS14350	COG2985	domain, Protein
GPY55_RS14355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY55_RS14370	COG1737	Transcriptional regulator
GPY55_RS14375	COG0076	glutamate decarboxylase activity
GPY55_RS14385	COG2431	L-lysine efflux transmembrane transporter activity
GPY55_RS14400	COG3070	regulator of competence-specific genes
GPY55_RS14415	COG4191	Histidine kinase
GPY55_RS14415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY55_RS14425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY55_RS14430	COG3048	D-serine ammonia-lyase activity
GPY55_RS14435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY55_RS14440	COG4988	ABC transporter
GPY55_RS14445	COG0492	ferredoxin-NADP+ reductase activity
GPY55_RS14455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY55_RS14465	COG3706	GGDEF domain
GPY55_RS14465	COG0745	RESPONSE REGULATOR receiver
GPY55_RS14470	COG0471	metal ion transport
GPY55_RS14475	COG2949	membrane
GPY55_RS14480	COG0281	malic enzyme
GPY55_RS14485	COG1643	Atp-dependent helicase
GPY55_RS14490	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY55_RS14505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY55_RS14540	COG0247	lactate metabolic process
GPY55_RS14540	COG0277	FAD linked oxidase domain protein
GPY55_RS14555	COG2986	histidine ammonia-lyase
GPY55_RS14560	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY55_RS14565	COG0010	Belongs to the arginase family
GPY55_RS14570	COG1228	amidohydrolase
GPY55_RS14575	COG2188	Transcriptional regulator
GPY55_RS14590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY55_RS14600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY55_RS14610	COG0393	Putative heavy-metal-binding
GPY55_RS14640	COG3706	GGDEF domain
GPY55_RS14645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY55_RS14650	COG0072	phenylalanine-tRNA ligase activity
GPY55_RS14650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY55_RS14665	COG0776	regulation of translation
GPY55_RS14675	COG0500	methyltransferase
GPY55_RS14680	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY55_RS14685	COG0295	cytidine deaminase activity
GPY55_RS14690	COG1346	cytolysis
GPY55_RS14695	COG1380	Effector of murein hydrolase LrgA
GPY55_RS14700	COG2925	Exonuclease
GPY55_RS14710	COG0702	epimerase
GPY55_RS14715	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY55_RS14720	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY55_RS14730	COG2062	phosphohistidine phosphatase, SixA
GPY55_RS14745	COG2988	succinylglutamate desuccinylase activity
GPY55_RS14750	COG4139	cobalamin transport
GPY55_RS14755	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY55_RS14775	COG0583	DNA-binding transcription factor activity
GPY55_RS14785	COG1451	nucleotide metabolic process
GPY55_RS14790	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY55_RS14820	COG3938	Belongs to the proline racemase family
GPY55_RS14840	COG2423	ornithine cyclodeaminase activity
GPY55_RS14845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY55_RS14850	COG3842	ATPase activity
GPY55_RS14855	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY55_RS14860	COG1177	transmembrane transport
GPY55_RS14870	COG3291	Pkd domain containing protein
GPY55_RS14890	COG0444	Belongs to the ABC transporter superfamily
GPY55_RS14895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY55_RS14900	COG0601	transmembrane transport
GPY55_RS14910	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY55_RS14920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY55_RS14930	COG0625	glutathione transferase activity
GPY55_RS15030	COG1278	Cold shock
GPY55_RS15035	COG0557	exoribonuclease II activity
GPY55_RS15080	COG1783	phage Terminase large subunit
GPY55_RS15230	COG1280	lysine exporter protein (LysE YggA)
GPY55_RS15280	COG1280	lysine exporter protein (LysE YggA)
GPY55_RS15285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY55_RS15305	COG1757	Na H antiporter
GPY55_RS15310	COG0174	glutamine synthetase
GPY55_RS15320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY55_RS15325	COG1396	sequence-specific DNA binding
GPY55_RS15325	COG1917	Cupin 2, conserved barrel domain protein
GPY55_RS15330	COG1012	belongs to the aldehyde dehydrogenase family
GPY55_RS15335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY55_RS15345	COG2957	Belongs to the agmatine deiminase family
GPY55_RS15350	COG1012	belongs to the aldehyde dehydrogenase family
GPY55_RS15355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY55_RS15360	COG1227	inorganic diphosphatase activity
GPY55_RS15375	COG2771	luxR family
GPY55_RS15375	COG2200	EAL domain
GPY55_RS15385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY55_RS15400	COG1846	Transcriptional regulator
GPY55_RS15405	COG2315	Protein conserved in bacteria
GPY55_RS15425	COG0110	maltose O-acetyltransferase activity
GPY55_RS15455	COG3063	Type IV pilus biogenesis stability protein PilW
GPY55_RS15460	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY55_RS15475	COG0531	amino acid
GPY55_RS15485	COG1560	Kdo2-lipid A biosynthetic process
GPY55_RS15495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GPY55_RS15600	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY55_RS15605	COG1280	lysine exporter protein (LysE YggA)
GPY55_RS15615	COG1115	amino acid carrier protein
GPY55_RS15640	COG1368	sulfuric ester hydrolase activity
GPY55_RS15645	COG0642	Histidine kinase
GPY55_RS15650	COG0745	RESPONSE REGULATOR receiver
GPY55_RS15660	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS15680	COG2113	Glycine betaine
GPY55_RS15685	COG4176	ABC-type proline glycine betaine transport system permease component
GPY55_RS15705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY55_RS15710	COG0456	acetyltransferase
GPY55_RS15715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY55_RS15720	COG0662	Cupin 2, conserved barrel domain protein
GPY55_RS15725	COG0527	aspartate kinase activity
GPY55_RS15740	COG1858	cytochrome C peroxidase
GPY55_RS15755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS15770	COG3290	protein histidine kinase activity
GPY55_RS15775	COG4565	transcriptional regulatory protein
GPY55_RS15780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY55_RS15785	COG0363	glucosamine-6-phosphate deaminase activity
GPY55_RS15790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY55_RS15825	COG3284	Transcriptional regulator
GPY55_RS15830	COG1012	belongs to the aldehyde dehydrogenase family
GPY55_RS15900	COG4669	(LipO)protein
GPY55_RS15920	COG3177	Filamentation induced by cAMP protein fic
GPY55_RS15965	COG0583	DNA-binding transcription factor activity
GPY55_RS15975	COG1073	alpha beta
GPY55_RS15980	COG1073	alpha beta
GPY55_RS15990	COG4792	protein secretion
GPY55_RS15995	COG4791	protein targeting
GPY55_RS16000	COG4794	Type iii secretion
GPY55_RS16005	COG4790	Type iii secretion
GPY55_RS16010	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY55_RS16075	COG0457	Tetratricopeptide repeat
GPY55_RS16095	COG0730	response to heat
GPY55_RS16125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY55_RS16130	COG0372	Belongs to the citrate synthase family
GPY55_RS16140	COG2828	Protein conserved in bacteria
GPY55_RS16150	COG0456	acetyltransferase
GPY55_RS16165	COG0561	phosphatase activity
GPY55_RS16170	COG0602	queuosine metabolic process
GPY55_RS16175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY55_RS16180	COG3706	GGDEF domain
GPY55_RS16230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY55_RS16235	COG0840	transmembrane signaling receptor activity
GPY55_RS16240	COG1254	Belongs to the acylphosphatase family
GPY55_RS16245	COG2920	part of a sulfur-relay system
GPY55_RS16255	COG0670	Belongs to the BI1 family
GPY55_RS16260	COG1126	abc transporter atp-binding protein
GPY55_RS16265	COG0765	amino acid transport
GPY55_RS16270	COG4597	amino acid ABC transporter
GPY55_RS16275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY55_RS16290	COG1666	GTP binding
GPY55_RS16295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY55_RS16315	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY55_RS16315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY55_RS16320	COG3008	intermembrane lipid transfer
GPY55_RS16325	COG2995	paraquat-inducible protein a
GPY55_RS16330	COG1132	(ABC) transporter
GPY55_RS16335	COG1956	GAF domain-containing protein
GPY55_RS16340	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY55_RS16355	COG0308	aminopeptidase N
GPY55_RS16370	COG0167	dihydroorotate dehydrogenase activity
GPY55_RS16385	COG0116	Belongs to the methyltransferase superfamily
GPY55_RS16385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY55_RS16410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY55_RS16415	COG1067	ATP-dependent peptidase activity
GPY55_RS16420	COG3120	sequence-specific DNA binding
GPY55_RS16455	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY55_RS16470	COG2010	Cytochrome c
GPY55_RS16480	COG2217	Heavy metal translocating P-type atpase
GPY55_RS16495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY55_RS16500	COG0589	response to stress
GPY55_RS16505	COG0037	tRNA processing
GPY55_RS16525	COG3842	ATPase activity
GPY55_RS16530	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY55_RS16535	COG1177	transmembrane transport
GPY55_RS16540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY55_RS16545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY55_RS16550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY55_RS16560	COG0004	ammonium transporteR
GPY55_RS16675	COG3209	COG3209 Rhs family protein
GPY55_RS16690	COG0437	4 iron, 4 sulfur cluster binding
GPY55_RS16695	COG0243	molybdopterin cofactor binding
GPY55_RS16695	COG3383	formate dehydrogenase (NAD+) activity
GPY55_RS16705	COG3381	protein complex oligomerization
GPY55_RS16730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY55_RS16735	COG0488	(ABC) transporter
GPY55_RS16745	COG4191	Histidine kinase
GPY55_RS16750	COG2204	response regulator
GPY55_RS16770	COG3842	ATPase activity
GPY55_RS16775	COG0746	molybdenum cofactor guanylyltransferase activity
GPY55_RS16780	COG0303	'Molybdopterin
GPY55_RS16795	COG0438	transferase activity, transferring glycosyl groups
GPY55_RS16800	COG1215	transferase activity, transferring glycosyl groups
GPY55_RS16805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY55_RS16815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY55_RS16830	COG1643	Atp-dependent helicase
GPY55_RS16835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY55_RS16850	COG3302	dmso reductase anchor subunit
GPY55_RS16855	COG0437	4 iron, 4 sulfur cluster binding
GPY55_RS16860	COG0243	molybdopterin cofactor binding
GPY55_RS16890	COG3706	GGDEF domain
GPY55_RS16900	COG0443	Heat shock 70 kDa protein
GPY55_RS16905	COG0443	Heat shock 70 kDa protein
GPY55_RS16935	COG1132	(ABC) transporter
GPY55_RS16940	COG1132	(ABC) transporter
GPY55_RS16965	COG0814	amino acid
GPY55_RS16980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY55_RS16990	COG0861	Integral membrane protein TerC family
GPY55_RS17000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY55_RS17005	COG1328	CTP reductase activity
GPY55_RS17010	COG1280	lysine exporter protein (LysE YggA)
GPY55_RS17020	COG3300	MHYT domain
GPY55_RS17020	COG5001	Diguanylate cyclase
GPY55_RS17030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY55_RS17030	COG4191	Histidine kinase
GPY55_RS17035	COG0471	metal ion transport
GPY55_RS17065	COG1940	carbohydrate kinase activity
GPY55_RS17105	COG3290	protein histidine kinase activity
GPY55_RS17105	COG0840	transmembrane signaling receptor activity
GPY55_RS17110	COG0791	NLP P60 protein
GPY55_RS17120	COG3706	GGDEF domain
GPY55_RS17125	COG2201	protein-glutamate methylesterase activity
GPY55_RS17140	COG0307	riboflavin synthase, alpha
GPY55_RS17145	COG0534	Mate efflux family protein
GPY55_RS17155	COG1793	dna ligase
GPY55_RS17190	COG2204	response regulator
GPY55_RS17470	COG2314	TM2 domain
GPY55_RS17690	COG0307	riboflavin synthase, alpha
GPY55_RS17855	COG0791	NLP P60 protein
GPY55_RS17930	COG0456	acetyltransferase
GPY55_RS17990	COG0456	acetyltransferase
GPY55_RS18260	COG2801	Transposase and inactivated derivatives
GPY55_RS18295	COG0454	-acetyltransferase
GPY55_RS18360	COG2026	Addiction module toxin, RelE StbE family
GPY55_RS18525	COG2026	Addiction module toxin, RelE StbE family
GPY55_RS18620	COG0346	lactoylglutathione lyase activity
GPY55_RS18690	COG0456	acetyltransferase
GPY55_RS18715	COG2226	methyltransferase
GPY55_RS18735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY55_RS18735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY55_RS18755	COG0791	NLP P60 protein
GPY55_RS18765	COG0456	acetyltransferase
GPY55_RS18855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY55_RS18865	COG3768	UPF0283 membrane protein
GPY55_RS18870	COG3106	COG3106 Predicted ATPase
GPY55_RS18890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY55_RS18895	COG0784	Response regulator, receiver
GPY55_RS18895	COG2205	protein histidine kinase activity
GPY55_RS18905	COG0494	nUDIX hydrolase
GPY55_RS18910	COG0814	amino acid
GPY55_RS18915	COG1760	l-serine dehydratase
GPY55_RS18920	COG2200	EAL domain
GPY55_RS18930	COG0720	synthase
GPY55_RS18940	COG0017	Asparaginyl-tRNA synthetase
GPY55_RS18950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY55_RS18975	COG1448	Aminotransferase
GPY55_RS18995	COG0840	transmembrane signaling receptor activity
GPY55_RS19000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY55_RS19005	COG1846	Transcriptional regulator
GPY55_RS19030	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY55_RS19045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY55_RS19050	COG3108	Peptidase M15
GPY55_RS19055	COG2989	Protein conserved in bacteria
GPY55_RS19080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY55_RS19090	COG4235	cytochrome complex assembly
GPY55_RS19090	COG3088	subunit of a heme lyase
GPY55_RS19100	COG1138	Cytochrome C-type biogenesis protein
GPY55_RS19105	COG3301	Polysulphide reductase, NrfD
GPY55_RS19110	COG0437	4 iron, 4 sulfur cluster binding
GPY55_RS19120	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY55_RS19140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY55_RS19145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY55_RS19150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY55_RS19175	COG0019	diaminopimelate decarboxylase activity
GPY55_RS19215	COG0322	excinuclease ABC activity
GPY55_RS19220	COG2197	response regulator
GPY55_RS19225	COG0417	DNA replication proofreading
GPY55_RS19235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY55_RS19240	COG3099	Belongs to the UPF0263 family
GPY55_RS19250	COG1187	pseudouridine synthase activity
GPY55_RS19260	COG0009	L-threonylcarbamoyladenylate synthase
GPY55_RS19265	COG0613	PHP domain protein
GPY55_RS19275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY55_RS19280	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY55_RS19285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY55_RS19290	COG0134	indole-3-glycerol-phosphate synthase activity
GPY55_RS19290	COG0135	phosphoribosylanthranilate isomerase activity
GPY55_RS19295	COG0133	tryptophan synthase activity
GPY55_RS19300	COG0159	tryptophan synthase activity
GPY55_RS19310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY55_RS19315	COG0318	PFAM AMP-dependent synthetase and ligase
GPY55_RS19325	COG1301	dicarboxylic acid transport
GPY55_RS19345	COG2917	probably involved in intracellular septation
GPY55_RS19350	COG1607	acyl-coa hydrolase
GPY55_RS19355	COG2350	Protein conserved in bacteria
GPY55_RS19365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY55_RS19375	COG0583	DNA-binding transcription factor activity
GPY55_RS19390	COG5001	Diguanylate cyclase
GPY55_RS19390	COG4251	negative regulation of phosphorylation
GPY55_RS19390	COG2203	Gaf domain
GPY55_RS19390	COG3706	GGDEF domain
GPY55_RS19395	COG1032	radical SAM domain protein
GPY55_RS19400	COG0840	transmembrane signaling receptor activity
GPY55_RS19410	COG0745	RESPONSE REGULATOR receiver
GPY55_RS19415	COG3850	Histidine kinase
GPY55_RS19415	COG5002	protein histidine kinase activity
GPY55_RS19455	COG1435	thymidine kinase activity
GPY55_RS19460	COG0215	cysteine-tRNA ligase activity
GPY55_RS19465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY55_RS19470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY55_RS19475	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY55_RS19485	COG3012	SEC-C Motif Domain Protein
GPY55_RS19490	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY55_RS19490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY55_RS19495	COG0107	imidazoleglycerol-phosphate synthase activity
GPY55_RS19500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY55_RS19505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY55_RS19510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY55_RS19510	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY55_RS19515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY55_RS19520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY55_RS19525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY55_RS19540	COG1757	Na H antiporter
GPY55_RS19550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY55_RS19560	COG0482	sulfurtransferase activity
GPY55_RS19565	COG2915	High frequency lysogenization protein hflD homolog
GPY55_RS19570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY55_RS19595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY55_RS19610	COG0300	oxidoreductase activity
GPY55_RS19620	COG0501	Belongs to the peptidase M48B family
GPY55_RS19630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY55_RS19640	COG0156	8-amino-7-oxononanoate synthase activity
GPY55_RS19645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY55_RS19650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY55_RS19655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY55_RS19670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY55_RS19675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY55_RS19680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY55_RS19685	COG1674	ftsk spoiiie
GPY55_RS19695	COG0686	Belongs to the AlaDH PNT family
GPY55_RS19705	COG0583	DNA-binding transcription factor activity
GPY55_RS19720	COG3568	Endonuclease Exonuclease Phosphatase
GPY55_RS19750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY55_RS19755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS19770	COG0840	transmembrane signaling receptor activity
GPY55_RS19785	COG0784	Response regulator, receiver
GPY55_RS19785	COG5002	protein histidine kinase activity
GPY55_RS19795	COG0754	glutathionylspermidine amidase activity
GPY55_RS19805	COG3766	membrane
GPY55_RS19815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY55_RS19820	COG0745	RESPONSE REGULATOR receiver
GPY55_RS19820	COG3706	GGDEF domain
GPY55_RS19825	COG0366	Alpha amylase catalytic
GPY55_RS19830	COG1122	ATPase activity
GPY55_RS19835	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY55_RS19845	COG3092	negative regulation of chromosome organization
GPY55_RS19850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY55_RS19855	COG0280	phosphate acetyltransferase
GPY55_RS19855	COG0857	belongs to the CobB CobQ family
GPY55_RS19860	COG3174	membrane
GPY55_RS19870	COG0435	Glutathione S-transferase
GPY55_RS19880	COG0444	Belongs to the ABC transporter superfamily
GPY55_RS19885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY55_RS19890	COG0601	transmembrane transport
GPY55_RS19900	COG0314	molybdopterin synthase activity
GPY55_RS19905	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY55_RS19910	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY55_RS19915	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY55_RS19920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY55_RS19925	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY55_RS19930	COG2198	Histidine kinase
GPY55_RS19935	COG2204	response regulator
GPY55_RS19940	COG0556	nucleotide-excision repair
GPY55_RS19975	COG4215	(ABC) transporter
GPY55_RS20005	COG1882	Formate acetyltransferase
GPY55_RS20015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY55_RS20025	COG3013	Belongs to the UPF0304 family
GPY55_RS20035	COG2766	serine protein kinase
GPY55_RS20040	COG2718	Belongs to the UPF0229 family
GPY55_RS20045	COG2719	SpoVR family
GPY55_RS20050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY55_RS20060	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY55_RS20065	COG1132	(ABC) transporter
GPY55_RS20070	COG0658	competence protein
GPY55_RS20070	COG2333	competence protein COMEC
GPY55_RS20080	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY55_RS20085	COG1136	(ABC) transporter
GPY55_RS20090	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY55_RS20115	COG1252	NADH dehydrogenase
GPY55_RS20125	COG3150	esterase
GPY55_RS20150	COG0537	adenosine 5'-monophosphoramidase activity
GPY55_RS20180	COG0516	GMP reductase activity
GPY55_RS20180	COG0517	IMP dehydrogenase activity
GPY55_RS20190	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY55_RS20195	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY55_RS20200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY55_RS20210	COG2199	diguanylate cyclase activity
GPY55_RS20225	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY55_RS20230	COG1946	Acyl-CoA thioesterase
GPY55_RS20240	COG1522	sequence-specific DNA binding
GPY55_RS20270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY55_RS20275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS20320	COG0477	Major facilitator Superfamily
GPY55_RS20325	COG2855	membrane
GPY55_RS20340	COG1441	menaquinone biosynthetic process
GPY55_RS20345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY55_RS20350	COG0596	Alpha beta hydrolase
GPY55_RS20355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY55_RS20360	COG1169	isochorismate synthase
GPY55_RS20365	COG0436	Aminotransferase
GPY55_RS20370	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY55_RS20375	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY55_RS20390	COG1555	photosystem II stabilization
GPY55_RS20395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY55_RS20400	COG0776	regulation of translation
GPY55_RS20405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY55_RS20410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY55_RS20420	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY55_RS20430	COG2204	response regulator
GPY55_RS20440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY55_RS20445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY55_RS20450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY55_RS20455	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY55_RS20475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY55_RS20480	COG0569	domain protein
GPY55_RS20485	COG0513	Belongs to the DEAD box helicase family
GPY55_RS20490	COG1253	flavin adenine dinucleotide binding
GPY55_RS20525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY55_RS20530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY55_RS20545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY55_RS20550	COG1216	Glycosyl transferase, family 2
GPY55_RS20555	COG2986	histidine ammonia-lyase
GPY55_RS20580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY55_RS20585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY55_RS20590	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS20610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY55_RS20615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY55_RS20620	COG0583	DNA-binding transcription factor activity
GPY55_RS20625	COG2951	lytic endotransglycosylase activity
GPY55_RS20630	COG3100	YcgL domain-containing protein
GPY55_RS20635	COG0850	regulation of cytokinetic process
GPY55_RS20640	COG2894	cell division
GPY55_RS20645	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY55_RS20650	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY55_RS20655	COG0318	PFAM AMP-dependent synthetase and ligase
GPY55_RS20660	COG2267	carboxylic ester hydrolase activity
GPY55_RS20675	COG1214	PFAM Peptidase M22, glycoprotease
GPY55_RS20680	COG1199	ATP-dependent helicase activity
GPY55_RS20685	COG0788	formyltetrahydrofolate deformylase activity
GPY55_RS20700	COG3102	Protein conserved in bacteria
GPY55_RS20710	COG0018	arginyl-trna synthetase
GPY55_RS20730	COG1918	ferrous iron import across plasma membrane
GPY55_RS20745	COG4977	sequence-specific DNA binding
GPY55_RS20750	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY55_RS20755	COG1121	(ABC) transporter
GPY55_RS20760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY55_RS20765	COG0121	glutamine amidotransferase
GPY55_RS20770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY55_RS20775	COG1960	acyl-CoA dehydrogenase activity
GPY55_RS20785	COG0456	acetyltransferase
GPY55_RS20805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY55_RS20810	COG0328	RNA-DNA hybrid ribonuclease activity
GPY55_RS20815	COG2226	methyltransferase
GPY55_RS20820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY55_RS20825	COG1388	LysM domain
GPY55_RS20825	COG0741	lytic transglycosylase activity
GPY55_RS20835	COG3021	interspecies interaction between organisms
GPY55_RS20840	COG0347	Belongs to the P(II) protein family
GPY55_RS20850	COG0037	tRNA processing
GPY55_RS20855	COG0825	malonyl-CoA metabolic process
GPY55_RS20860	COG0587	DNA-directed DNA polymerase activity
GPY55_RS20870	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY55_RS20875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY55_RS20880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY55_RS20885	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY55_RS20895	COG0750	zinc metalloprotease
GPY55_RS20900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY55_RS20905	COG0575	Belongs to the CDS family
GPY55_RS20910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY55_RS20915	COG0233	cytoplasmic translational termination
GPY55_RS20920	COG0528	UMP kinase activity
GPY55_RS20925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY55_RS20930	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY55_RS20935	COG0024	Methionine aminopeptidase
GPY55_RS20940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY55_RS20950	COG0564	pseudouridine synthase activity
GPY55_RS20955	COG3098	single-species biofilm formation
GPY55_RS20980	COG1671	Belongs to the UPF0178 family
GPY55_RS20985	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY55_RS20995	COG0254	rRNA binding
GPY55_RS21000	COG1720	tRNA m6t6A37 methyltransferase activity
GPY55_RS21005	COG0442	prolyl-tRNA aminoacylation
GPY55_RS21025	COG0733	neurotransmitter:sodium symporter activity
GPY55_RS21040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY55_RS21045	COG0514	ATP-dependent DNA helicase (RecQ)
GPY55_RS21050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY55_RS21065	COG1477	protein flavinylation
GPY55_RS21070	COG2871	sodium ion transport
GPY55_RS21075	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY55_RS21080	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY55_RS21085	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY55_RS21090	COG1805	sodium ion transport
GPY55_RS21095	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY55_RS21100	COG0271	Belongs to the BolA IbaG family
GPY55_RS21105	COG2813	Specifically methylates the guanine in position
GPY55_RS21110	COG3056	Lipoprotein
GPY55_RS21130	COG1595	DNA-templated transcription, initiation
GPY55_RS21155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY55_RS21160	COG0693	protein deglycase activity
GPY55_RS21165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY55_RS21170	COG3706	GGDEF domain
GPY55_RS21175	COG2166	iron-sulfur cluster assembly
GPY55_RS21180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY55_RS21185	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY55_RS21195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY55_RS21195	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY55_RS21215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY55_RS21220	COG1074	ATP-dependent DNA helicase activity
GPY55_RS21225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY55_RS21245	COG3141	response to X-ray
GPY55_RS21250	COG2171	N-acyltransferase activity
GPY55_RS21255	COG0584	glycerophosphoryl diester phosphodiesterase
GPY55_RS21260	COG2271	Major facilitator Superfamily
GPY55_RS21275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY55_RS21280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY55_RS21285	COG1349	DNA-binding transcription factor activity
GPY55_RS21290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY55_RS21295	COG0598	Magnesium transport protein CorA
GPY55_RS21310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY55_RS21315	COG1609	Transcriptional regulator
GPY55_RS21320	COG2176	DNA-directed DNA polymerase activity
GPY55_RS21335	COG2017	converts alpha-aldose to the beta-anomer
GPY55_RS21340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY55_RS21350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY55_RS21360	COG1609	Transcriptional regulator
GPY55_RS21365	COG3250	beta-galactosidase activity
GPY55_RS21370	COG2731	YhcH YjgK YiaL family protein
GPY55_RS21375	COG0531	amino acid
GPY55_RS21380	COG0583	DNA-binding transcription factor activity
GPY55_RS21440	COG4964	Belongs to the GSP D family
GPY55_RS21465	COG2169	Transcriptional regulator
GPY55_RS21470	COG1022	Amp-dependent synthetase and ligase
GPY55_RS21480	COG0583	DNA-binding transcription factor activity
GPY55_RS21485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY55_RS21490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY55_RS21500	COG0560	Phosphoserine phosphatase
GPY55_RS21510	COG0813	purine-nucleoside phosphorylase activity
GPY55_RS21515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY55_RS21520	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY55_RS21525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY55_RS21530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY55_RS21535	COG0084	hydrolase, TatD family'
GPY55_RS21545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY55_RS21565	COG3153	acetyltransferase
GPY55_RS21590	COG0534	Mate efflux family protein
GPY55_RS21600	COG4785	May be involved in cell division
GPY55_RS21605	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY55_RS21610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY55_RS21615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY55_RS21620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY55_RS21625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY55_RS21630	COG0195	Participates in both transcription termination and antitermination
GPY55_RS21635	COG0779	Required for maturation of 30S ribosomal subunits
GPY55_RS21650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY55_RS21660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY55_RS21665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY55_RS21670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY55_RS21675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY55_RS21680	COG1534	Rna-binding protein
GPY55_RS21685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY55_RS21690	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY55_RS21695	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY55_RS21710	COG0590	tRNA wobble adenosine to inosine editing
GPY55_RS21715	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY55_RS21745	COG0484	heat shock protein binding
GPY55_RS21750	COG0443	Heat shock 70 kDa protein
GPY55_RS21760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY55_RS21765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY55_RS21775	COG0497	DNA recombination
GPY55_RS21780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY55_RS21785	COG2914	Belongs to the UPF0125 (RnfH) family
GPY55_RS21790	COG2867	negative regulation of translational initiation
GPY55_RS21795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY55_RS21810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY55_RS21830	COG0583	DNA-binding transcription factor activity
GPY55_RS21835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY55_RS21835	COG3153	acetyltransferase
GPY55_RS21855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY55_RS21860	COG2873	o-acetylhomoserine
GPY55_RS21895	COG1115	amino acid carrier protein
GPY55_RS21905	COG1584	GPR1 FUN34 yaaH family protein
GPY55_RS21915	COG1757	Na H antiporter
GPY55_RS21960	COG1538	Outer membrane efflux protein
GPY55_RS21980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY55_RS21985	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY55_RS21990	COG0247	lactate metabolic process
GPY55_RS22005	COG3344	reverse transcriptase
GPY55_RS22075	COG0582	viral genome integration into host DNA
GPY55_RS22080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY55_RS22080	COG0519	Catalyzes the synthesis of GMP from XMP
GPY55_RS22085	COG0517	IMP dehydrogenase activity
GPY55_RS22085	COG0516	GMP reductase activity
GPY55_RS22090	COG1570	exodeoxyribonuclease VII activity
GPY55_RS22105	COG1160	GTP binding
GPY55_RS22110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY55_RS22115	COG2976	Protein conserved in bacteria
GPY55_RS22120	COG0124	histidyl-tRNA synthetase
GPY55_RS22125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY55_RS22140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY55_RS22145	COG0105	UTP biosynthetic process
GPY55_RS22150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY55_RS22155	COG2975	iron-sulfur cluster assembly
GPY55_RS22160	COG0633	Ferredoxin
GPY55_RS22165	COG0443	Heat shock 70 kDa protein
GPY55_RS22170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY55_RS22180	COG0822	iron-sulfur transferase activity
GPY55_RS22185	COG1104	cysteine desulfurase activity
GPY55_RS22200	COG0483	inositol monophosphate 1-phosphatase activity
GPY55_RS22210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY55_RS22215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY55_RS22220	COG1862	Preprotein translocase
GPY55_RS22225	COG0343	queuine tRNA-ribosyltransferase activity
GPY55_RS22230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY55_RS22240	COG0517	IMP dehydrogenase activity
GPY55_RS22250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY55_RS22260	COG0583	DNA-binding transcription factor activity
GPY55_RS22265	COG0450	alkyl hydroperoxide reductase
GPY55_RS22270	COG3142	Participates in the control of copper homeostasis
GPY55_RS22280	COG0704	Plays a role in the regulation of phosphate uptake
GPY55_RS22285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY55_RS22290	COG0581	inorganic phosphate transmembrane transporter activity
GPY55_RS22300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY55_RS22305	COG0248	Ppx GppA phosphatase
GPY55_RS22315	COG5002	protein histidine kinase activity
GPY55_RS22320	COG0745	RESPONSE REGULATOR receiver
GPY55_RS22325	COG2974	May be involved in recombination
GPY55_RS22335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY55_RS22395	COG0542	response to heat
GPY55_RS22405	COG0564	pseudouridine synthase activity
GPY55_RS22410	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY55_RS22415	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY55_RS22420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY55_RS22425	COG1605	Chorismate mutase
GPY55_RS22425	COG0077	Prephenate dehydratase
GPY55_RS22430	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY55_RS22435	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY55_RS22445	COG0488	(ABC) transporter
GPY55_RS22460	COG0739	heme binding
GPY55_RS22465	COG1605	Chorismate mutase
GPY55_RS22465	COG0287	Prephenate dehydrogenase
GPY55_RS22470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY55_RS22475	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY55_RS22480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY55_RS22485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY55_RS22500	COG1966	Carbon starvation protein
GPY55_RS22505	COG3275	phosphorelay sensor kinase activity
GPY55_RS22510	COG3279	Response regulator of the LytR AlgR family
GPY55_RS22515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY55_RS22520	COG1047	Peptidyl-prolyl cis-trans
GPY55_RS22525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY55_RS22530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY55_RS22535	COG0196	riboflavin kinase activity
GPY55_RS22540	COG0728	peptidoglycan biosynthetic process
GPY55_RS22545	COG0268	Binds directly to 16S ribosomal RNA
GPY55_RS22555	COG0640	Transcriptional regulator
GPY55_RS22565	COG0583	DNA-binding transcription factor activity
GPY55_RS22570	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY55_RS22580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY55_RS22585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY55_RS22590	COG0730	response to heat
GPY55_RS22600	COG0494	nUDIX hydrolase
GPY55_RS22620	COG0667	Aldo Keto reductase
GPY55_RS22635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY55_RS22645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY55_RS22650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY55_RS22660	COG0716	FMN binding
GPY55_RS22670	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY55_RS22675	COG0513	Belongs to the DEAD box helicase family
GPY55_RS22680	COG3328	transposase activity
GPY55_RS22685	COG3022	response to hydroperoxide
GPY55_RS22690	COG1115	amino acid carrier protein
GPY55_RS22705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY55_RS22715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY55_RS22720	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY55_RS22725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY55_RS22730	COG0083	homoserine kinase activity
GPY55_RS22745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY55_RS22760	COG0745	RESPONSE REGULATOR receiver
GPY55_RS22770	COG5002	protein histidine kinase activity
GPY55_RS22770	COG2198	Histidine kinase
GPY55_RS22770	COG0784	Response regulator, receiver
GPY55_RS22775	COG3706	GGDEF domain
GPY55_RS22775	COG5001	Diguanylate cyclase
GPY55_RS22775	COG4251	negative regulation of phosphorylation
GPY55_RS22775	COG2203	Gaf domain
GPY55_RS22780	COG1242	4 iron, 4 sulfur cluster binding
GPY55_RS22785	COG0070	glutamate synthase
GPY55_RS22785	COG0069	glutamate synthase activity
GPY55_RS22785	COG0067	glutamate synthase
GPY55_RS22795	COG0070	glutamate synthase
GPY55_RS22795	COG0069	glutamate synthase activity
GPY55_RS22795	COG0067	glutamate synthase
GPY55_RS22800	COG0493	'glutamate synthase
GPY55_RS22810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY55_RS22820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY55_RS22825	COG2860	membrane
GPY55_RS22830	COG0583	DNA-binding transcription factor activity
GPY55_RS22835	COG0730	response to heat
GPY55_RS22850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY55_RS22855	COG0505	Belongs to the CarA family
GPY55_RS22860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY55_RS22865	COG0494	nUDIX hydrolase
GPY55_RS22870	COG0653	protein targeting
GPY55_RS22880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY55_RS22885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY55_RS22890	COG0849	cell division
GPY55_RS22895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY55_RS22900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY55_RS22905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY55_RS22910	COG0772	Belongs to the SEDS family
GPY55_RS22915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY55_RS22920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY55_RS22925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY55_RS22930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY55_RS22935	COG0768	penicillin binding
GPY55_RS22940	COG3116	cell division
GPY55_RS22945	COG0275	rRNA processing
GPY55_RS22960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY55_RS22970	COG0792	nuclease activity
GPY55_RS22975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY55_RS22980	COG2823	Periplasmic or secreted lipoprotein
GPY55_RS22985	COG2969	positive regulation of protein catabolic process
GPY55_RS22990	COG0625	glutathione transferase activity
GPY55_RS22995	COG2857	Cytochrome c1
GPY55_RS23000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY55_RS23005	COG0723	plastoquinol--plastocyanin reductase activity
GPY55_RS23010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY55_RS23015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY55_RS23025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY55_RS23035	COG3105	Protein conserved in bacteria
GPY55_RS23045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY55_RS23050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY55_RS23055	COG0187	DNA topoisomerase II activity
GPY55_RS23060	COG3150	esterase
GPY55_RS23070	COG3151	Protein conserved in bacteria
GPY55_RS23075	COG0494	nUDIX hydrolase
GPY55_RS23080	COG1538	Outer membrane efflux protein
GPY55_RS23085	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY55_RS23085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY55_RS23090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY55_RS23105	COG3025	triphosphatase activity
GPY55_RS23110	COG1392	Phosphate transport regulator
GPY55_RS23115	COG0306	phosphate transporter
GPY55_RS23120	COG4991	sh3 domain protein
GPY55_RS23130	COG3267	Type II secretory pathway component ExeA
GPY55_RS23130	COG3409	Peptidoglycan-binding domain 1 protein
GPY55_RS23135	COG0617	tRNA 3'-terminal CCA addition
GPY55_RS23140	COG1968	undecaprenyl-diphosphatase activity
GPY55_RS23145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY55_RS23150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY55_RS23155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY55_RS23160	COG0596	Alpha beta hydrolase
GPY55_RS23165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY55_RS23170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY55_RS23175	COG1610	YqeY-like protein
GPY55_RS23180	COG0358	DNA primase activity
GPY55_RS23185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY55_RS23235	COG1464	Belongs to the NlpA lipoprotein family
GPY55_RS23270	COG2213	PTS system mannitol-specific
GPY55_RS23270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS23275	COG0246	Mannitol dehydrogenase
GPY55_RS23280	COG3722	fumarate hydratase activity
GPY55_RS23295	COG1461	Dihydroxyacetone kinase
GPY55_RS23300	COG2376	Dihydroxyacetone kinase
GPY55_RS23310	COG5002	protein histidine kinase activity
GPY55_RS23325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY55_RS23330	COG1349	DNA-binding transcription factor activity
GPY55_RS23340	COG0469	pyruvate kinase activity
GPY55_RS23350	COG3706	GGDEF domain
GPY55_RS23355	COG0440	acetolactate synthase activity
GPY55_RS23360	COG0028	Belongs to the TPP enzyme family
GPY55_RS23365	COG1022	Amp-dependent synthetase and ligase
GPY55_RS23370	COG0583	DNA-binding transcription factor activity
GPY55_RS23390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY55_RS23395	COG0473	3-isopropylmalate dehydrogenase activity
GPY55_RS23400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY55_RS23405	COG0066	3-isopropylmalate dehydratase activity
GPY55_RS23415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY55_RS23420	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY55_RS23425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY55_RS23430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY55_RS23435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY55_RS23440	COG2967	ApaG domain
GPY55_RS23445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY55_RS23460	COG2966	Psort location CytoplasmicMembrane, score
GPY55_RS23465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY55_RS23475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY55_RS23480	COG0142	geranyltranstransferase activity
GPY55_RS23490	COG0039	L-malate dehydrogenase activity
GPY55_RS23525	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY55_RS23530	COG1178	ABC-type Fe3 transport system permease component
GPY55_RS23535	COG4143	(ABC) transporter
GPY55_RS23540	COG0163	prenyltransferase activity
GPY55_RS23545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY55_RS23555	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY55_RS23560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY55_RS23570	COG2105	PFAM AIG2 family protein
GPY55_RS23580	COG0729	surface antigen
GPY55_RS23585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY55_RS23595	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY55_RS23610	COG4181	ATPase activity
GPY55_RS23630	COG0529	Catalyzes the synthesis of activated sulfate
GPY55_RS23635	COG3273	potassium ion transport
GPY55_RS23635	COG0471	metal ion transport
GPY55_RS23645	COG2895	sulfate adenylyltransferase (ATP) activity
GPY55_RS23650	COG0175	sulfate reduction
GPY55_RS23655	COG1648	precorrin-2 dehydrogenase activity
GPY55_RS23655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY55_RS23660	COG0737	Belongs to the 5'-nucleotidase family
GPY55_RS23670	COG0513	Belongs to the DEAD box helicase family
GPY55_RS23675	COG2153	protein acetylation
GPY55_RS23685	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY55_RS23695	COG0203	ribosomal protein L17
GPY55_RS23700	COG0202	RNA polymerase activity
GPY55_RS23710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY55_RS23715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY55_RS23725	COG0201	protein transport
GPY55_RS23730	COG0200	Binds to the 23S rRNA
GPY55_RS23735	COG1841	ribosomal large subunit assembly
GPY55_RS23750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY55_RS23755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY55_RS23760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY55_RS23765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY55_RS23770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY55_RS23775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY55_RS23780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY55_RS23785	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY55_RS23795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY55_RS23800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY55_RS23805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY55_RS23810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY55_RS23820	COG0088	Forms part of the polypeptide exit tunnel
GPY55_RS23825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY55_RS23835	COG0254	rRNA binding
GPY55_RS23845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY55_RS23850	COG1609	Transcriptional regulator
GPY55_RS23860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY55_RS23865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY55_RS23870	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY55_RS23875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY55_RS23880	COG3074	FtsZ-dependent cytokinesis
GPY55_RS23890	COG1494	fructose-1,6-bisphosphatase
GPY55_RS23915	COG0149	triose-phosphate isomerase activity
GPY55_RS23940	COG0438	transferase activity, transferring glycosyl groups
GPY55_RS23940	COG1216	Glycosyl transferase, family 2
GPY55_RS23950	COG0471	metal ion transport
GPY55_RS23950	COG3273	potassium ion transport
GPY55_RS23980	COG0438	transferase activity, transferring glycosyl groups
GPY55_RS23980	COG1216	Glycosyl transferase, family 2
GPY55_RS23995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY55_RS24000	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPY55_RS24065	COG1088	dTDP-glucose 4,6-dehydratase activity
GPY55_RS24110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY55_RS24140	COG3156	type II secretion system protein K
GPY55_RS24160	COG1459	type II secretion system
GPY55_RS24165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY55_RS24180	COG0175	sulfate reduction
GPY55_RS24185	COG0529	Catalyzes the synthesis of activated sulfate
GPY55_RS24195	COG2895	sulfate adenylyltransferase (ATP) activity
GPY55_RS24200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY55_RS24225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY55_RS24235	COG1560	Kdo2-lipid A biosynthetic process
GPY55_RS24240	COG0859	PFAM glycosyl transferase family 9
GPY55_RS24245	COG1519	Transferase
GPY55_RS24260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GPY55_RS24270	COG2089	acid synthase
GPY55_RS24275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY55_RS24280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY55_RS24290	COG1045	serine acetyltransferase
GPY55_RS24310	COG3642	lipopolysaccharide core region biosynthetic process
GPY55_RS24315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY55_RS24320	COG0859	PFAM glycosyl transferase family 9
GPY55_RS24325	COG0463	Glycosyl transferase, family 2
GPY55_RS24335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY55_RS24345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY55_RS24360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY55_RS24365	COG2003	Belongs to the UPF0758 family
GPY55_RS24380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY55_RS24385	COG1309	transcriptional regulator
GPY55_RS24390	COG1560	Kdo2-lipid A biosynthetic process
GPY55_RS24395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY55_RS24400	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY55_RS24405	COG1561	YicC-like family, N-terminal region
GPY55_RS24465	COG3311	Transcriptional regulator
GPY55_RS24470	COG2003	Belongs to the UPF0758 family
GPY55_RS24510	COG4608	Belongs to the ABC transporter superfamily
GPY55_RS24515	COG0444	Belongs to the ABC transporter superfamily
GPY55_RS24520	COG0747	negative chemotaxis
GPY55_RS24525	COG4239	(ABC) transporter, permease
GPY55_RS24530	COG4174	ABC transporter (Permease)
GPY55_RS24555	COG0811	peptide transport
GPY55_RS24560	COG0848	biopolymer transport protein
GPY55_RS24575	COG0194	GDP metabolic process
GPY55_RS24580	COG1758	RNA polymerase activity
GPY55_RS24585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY55_RS24590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY55_RS24595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY55_RS24600	COG2233	PERMEase
GPY55_RS24605	COG2205	protein histidine kinase activity
GPY55_RS24610	COG0745	RESPONSE REGULATOR receiver
GPY55_RS24620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY55_RS24630	COG2183	response to ionizing radiation
GPY55_RS24640	COG0596	Alpha beta hydrolase
GPY55_RS24645	COG1040	competence protein
GPY55_RS24650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY55_RS24650	COG0316	Belongs to the HesB IscA family
GPY55_RS24655	COG0494	nUDIX hydrolase
GPY55_RS24660	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY55_RS24670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY55_RS24675	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY55_RS24680	COG3156	type II secretion system protein K
GPY55_RS24685	COG4795	General secretion pathway protein
GPY55_RS24690	COG2165	general secretion pathway protein
GPY55_RS24695	COG2165	general secretion pathway protein
GPY55_RS24700	COG2165	general secretion pathway protein
GPY55_RS24705	COG1459	type II secretion system
GPY55_RS24710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY55_RS24720	COG3031	protein transport across the cell outer membrane
GPY55_RS24725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY55_RS24730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY55_RS24735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY55_RS24745	COG0456	acetyltransferase
GPY55_RS24750	COG1490	D-aminoacyl-tRNA deacylase activity
GPY55_RS24755	COG1295	ribonuclease BN
GPY55_RS24775	COG0174	glutamine synthetase
GPY55_RS24785	COG3852	Histidine kinase
GPY55_RS24790	COG2204	response regulator
GPY55_RS24800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY55_RS24805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY55_RS24840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY55_RS24850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY55_RS24850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY55_RS24875	COG0084	hydrolase, TatD family'
GPY55_RS24885	COG0805	protein transport
GPY55_RS24895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY55_RS24900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY55_RS24905	COG3165	ubiquinone biosynthetic process from chorismate
GPY55_RS24910	COG2226	methyltransferase
GPY55_RS24915	COG1322	Protein conserved in bacteria
GPY55_RS24930	COG0628	permease
GPY55_RS24980	COG2823	Periplasmic or secreted lipoprotein
GPY55_RS24990	COG2081	HI0933 family
GPY55_RS25000	COG1528	Iron-storage protein
GPY55_RS25005	COG0589	response to stress
GPY55_RS25010	COG0697	spore germination
GPY55_RS25020	COG0742	ribosomal rna small subunit methyltransferase
GPY55_RS25025	COG5002	protein histidine kinase activity
GPY55_RS25025	COG5001	Diguanylate cyclase
GPY55_RS25030	COG1522	sequence-specific DNA binding
GPY55_RS25035	COG0339	signal peptide processing
GPY55_RS25040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY55_RS25045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY55_RS25070	COG3328	transposase activity
GPY55_RS25075	COG1404	Belongs to the peptidase S8 family
GPY55_RS25080	COG0464	growth
GPY55_RS25100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY55_RS25140	COG0640	Transcriptional regulator
GPY55_RS25155	COG0786	glutamate:sodium symporter activity
GPY55_RS25180	COG0583	DNA-binding transcription factor activity
GPY55_RS25185	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY55_RS25190	COG0800	Aldolase
GPY55_RS25195	COG2610	gluconate transmembrane transporter activity
GPY55_RS25200	COG3265	gluconokinase activity
GPY55_RS25210	COG2076	Multidrug Resistance protein
GPY55_RS25220	COG0583	DNA-binding transcription factor activity
GPY55_RS25225	COG1609	Transcriptional regulator
GPY55_RS25265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY55_RS25275	COG0747	negative chemotaxis
GPY55_RS25280	COG4172	Belongs to the ABC transporter superfamily
GPY55_RS25345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY55_RS25350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY55_RS25360	COG2960	long-chain fatty acid transporting porin activity
GPY55_RS25365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY55_RS25370	COG0583	DNA-binding transcription factor activity
GPY55_RS25415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY55_RS25420	COG1739	Uncharacterized protein family UPF0029
GPY55_RS25425	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY55_RS25425	COG1024	Enoyl-CoA hydratase
GPY55_RS25430	COG0183	Belongs to the thiolase family
GPY55_RS25435	COG0604	alcohol dehydrogenase
GPY55_RS25450	COG0425	Belongs to the sulfur carrier protein TusA family
GPY55_RS25460	COG2119	membrane
GPY55_RS25465	COG0752	glycyl-tRNA synthetase alpha subunit
GPY55_RS25470	COG0751	glycine-tRNA ligase activity
GPY55_RS25475	COG0366	Alpha amylase catalytic
GPY55_RS25480	COG3977	Valine--pyruvate aminotransferase
GPY55_RS25485	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY55_RS25505	COG0187	DNA topoisomerase II activity
GPY55_RS25510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY55_RS25515	COG0592	DNA-directed DNA polymerase activity
GPY55_RS25520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY55_RS25545	COG1126	abc transporter atp-binding protein
GPY55_RS25555	COG0594	ribonuclease P activity
GPY55_RS25560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY55_RS25565	COG0706	membrane insertase activity
GPY55_RS25570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY55_RS25575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY55_RS25580	COG0445	tRNA wobble uridine modification
GPY55_RS25585	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY55_RS25590	COG1192	Involved in chromosome partitioning
GPY55_RS25595	COG1475	DNA binding
GPY55_RS25600	COG3312	ion transport
GPY55_RS25605	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY55_RS25620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY55_RS25625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY55_RS25630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY55_RS25635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY55_RS25640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY55_RS25650	COG0765	amino acid transport
GPY55_RS25655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY55_RS25660	COG2814	Major facilitator Superfamily
GPY55_RS25665	COG0583	DNA-binding transcription factor activity
GPY55_RS25675	COG0129	dihydroxy-acid dehydratase activity
GPY55_RS25680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY55_RS25685	COG3978	acetolactate synthase activity
GPY55_RS25695	COG0606	chelatase, subunit chli
GPY55_RS25705	COG0204	Acyl-transferase
GPY55_RS25710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY55_RS25715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY55_RS25725	COG3084	Protein conserved in bacteria
GPY55_RS25735	COG4326	sporulation control protein
GPY55_RS25740	COG1272	protein, Hemolysin III
GPY55_RS25750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY55_RS25755	COG0569	domain protein
GPY55_RS25760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY55_RS25760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY55_RS25765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY55_RS25770	COG0242	peptide deformylase activity
GPY55_RS25780	COG0758	DNA mediated transformation
GPY55_RS25785	COG2922	Belongs to the Smg family
GPY55_RS25790	COG0551	DNA topoisomerase type I activity
GPY55_RS25795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY55_RS25800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY55_RS25805	COG0009	L-threonylcarbamoyladenylate synthase
GPY55_RS25810	COG0408	coproporphyrinogen oxidase activity
GPY55_RS25815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY55_RS25825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY55_RS25870	COG3335	DDE superfamily endonuclease
GPY55_RS25880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY55_RS25885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY55_RS25895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY55_RS25900	COG2104	thiamine diphosphate biosynthetic process
GPY55_RS25905	COG2022	thiamine diphosphate biosynthetic process
GPY55_RS25915	COG0006	proline dipeptidase activity
GPY55_RS25915	COG0006	proline dipeptidase activity
GPY55_RS25945	COG3220	belongs to the UPF0276 family
GPY55_RS25955	COG0210	DNA helicase
GPY55_RS25965	COG0405	Gamma-glutamyltransferase
GPY55_RS25970	COG1280	lysine exporter protein (LysE YggA)
GPY55_RS25980	COG2962	Rard protein
GPY55_RS25985	COG0514	ATP-dependent DNA helicase (RecQ)
GPY55_RS26000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY55_RS26005	COG0248	Ppx GppA phosphatase
GPY55_RS26010	COG0513	Belongs to the DEAD box helicase family
GPY55_RS26015	COG3118	belongs to the thioredoxin family
GPY55_RS26020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY55_RS26035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY55_RS26040	COG0633	Ferredoxin
GPY55_RS26090	COG3071	HemY protein
GPY55_RS26095	COG2959	enzyme of heme biosynthesis
GPY55_RS26100	COG1587	Uroporphyrinogen-III synthase
GPY55_RS26105	COG0181	hydroxymethylbilane synthase activity
GPY55_RS26110	COG3072	Adenylate cyclase
GPY55_RS26115	COG1965	Belongs to the frataxin family
GPY55_RS26125	COG0019	diaminopimelate decarboxylase activity
GPY55_RS26130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY55_RS26140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY55_RS26145	COG1011	Hydrolase
GPY55_RS26150	COG2200	EAL domain
GPY55_RS26150	COG3287	FIST C domain
GPY55_RS26150	COG2199	diguanylate cyclase activity
GPY55_RS26170	COG0561	phosphatase activity
GPY55_RS26175	COG2267	carboxylic ester hydrolase activity
GPY55_RS26180	COG1280	lysine exporter protein (LysE YggA)
GPY55_RS26185	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY55_RS26190	COG0640	Transcriptional regulator
GPY55_RS26195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY55_RS26250	COG2095	MarC family integral membrane protein
GPY55_RS26260	COG0742	ribosomal rna small subunit methyltransferase
GPY55_RS26265	COG0552	protein localization to endoplasmic reticulum
GPY55_RS26270	COG2884	Cell division ATP-binding protein ftsE
GPY55_RS26275	COG2177	Part of the ABC transporter FtsEX involved in
GPY55_RS26285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY55_RS26290	COG0705	Rhomboid family
GPY55_RS26295	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY55_RS26300	COG3161	chorismate lyase activity
GPY55_RS26305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY55_RS26310	COG2937	Belongs to the GPAT DAPAT family
GPY55_RS26320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY55_RS26325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY55_RS26330	COG0534	Mate efflux family protein
GPY55_RS26335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY55_RS26355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY55_RS26360	COG3119	arylsulfatase activity
GPY55_RS26365	COG1349	DNA-binding transcription factor activity
GPY55_RS26375	COG2222	sugar isomerase
GPY55_RS26380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY55_RS26385	COG3715	PTS system
GPY55_RS26390	COG3716	PTS system mannose fructose sorbose family IID component
GPY55_RS26395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY55_RS26400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY55_RS26410	COG1028	Short-chain dehydrogenase reductase Sdr
GPY55_RS26420	COG3119	arylsulfatase activity
GPY55_RS26435	COG0641	radical SAM
GPY55_RS26440	COG3119	arylsulfatase activity
GPY55_RS26450	COG0191	fructose-bisphosphate aldolase activity
GPY55_RS26455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY55_RS26460	COG0800	Aldolase
GPY55_RS26495	COG2003	Belongs to the UPF0758 family
GPY55_RS26510	COG3339	Conserved Protein
GPY55_RS26565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY55_RS26570	COG4206	TonB-dependent receptor
GPY55_RS26580	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY55_RS26610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY55_RS26620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY55_RS26655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY55_RS26665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY55_RS26670	COG0250	Participates in transcription elongation, termination and antitermination
GPY55_RS26675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY55_RS26680	COG0081	regulation of translation
GPY55_RS26685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY55_RS26690	COG0222	ribosome binding
GPY55_RS26695	COG0085	RNA polymerase activity
GPY55_RS26700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY55_RS26705	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY55_RS26710	COG2816	NAD+ diphosphatase activity
GPY55_RS26725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY55_RS26730	COG1573	uracil-dna glycosylase
GPY55_RS26735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY55_RS26740	COG3068	Protein conserved in bacteria
GPY55_RS26745	COG1253	flavin adenine dinucleotide binding
GPY55_RS26760	COG0151	Belongs to the GarS family
GPY55_RS26770	COG0138	bifunctional purine biosynthesis protein purh
GPY55_RS26780	COG0789	Transcriptional regulator
GPY55_RS26785	COG3710	Transcriptional regulator
GPY55_RS26795	COG0531	amino acid
GPY55_RS26800	COG1982	Orn Lys Arg decarboxylase major
GPY55_RS26895	COG3706	GGDEF domain
GPY55_RS26900	COG0488	(ABC) transporter
GPY55_RS26930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY55_RS26960	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY55_RS26965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY55_RS26970	COG2264	protein methyltransferase activity
GPY55_RS26980	COG0439	Biotin carboxylase
GPY55_RS26985	COG0511	ligase activity, forming carbon-carbon bonds
GPY55_RS26990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY55_RS26995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY55_RS27010	COG2814	Major facilitator Superfamily