locus-tag	class	description
Vp2S01_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Vp2S01_RS00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Vp2S01_RS00015	COG0706	membrane insertase activity
Vp2S01_RS00025	COG0594	ribonuclease P activity
Vp2S01_RS00035	COG1126	abc transporter atp-binding protein
Vp2S01_RS00060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Vp2S01_RS00065	COG0592	DNA-directed DNA polymerase activity
Vp2S01_RS00070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Vp2S01_RS00075	COG0187	DNA topoisomerase II activity
Vp2S01_RS00095	COG0071	Belongs to the small heat shock protein (HSP20) family
Vp2S01_RS00100	COG3977	Valine--pyruvate aminotransferase
Vp2S01_RS00105	COG0366	Alpha amylase catalytic
Vp2S01_RS00110	COG0751	glycine-tRNA ligase activity
Vp2S01_RS00115	COG0752	glycyl-tRNA synthetase alpha subunit
Vp2S01_RS00120	COG2119	membrane
Vp2S01_RS00130	COG0425	Belongs to the sulfur carrier protein TusA family
Vp2S01_RS00145	COG0604	alcohol dehydrogenase
Vp2S01_RS00150	COG0183	Belongs to the thiolase family
Vp2S01_RS00155	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vp2S01_RS00155	COG1024	Enoyl-CoA hydratase
Vp2S01_RS00160	COG1739	Uncharacterized protein family UPF0029
Vp2S01_RS00165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vp2S01_RS00225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Vp2S01_RS00230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Vp2S01_RS00240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vp2S01_RS00245	COG2104	thiamine diphosphate biosynthetic process
Vp2S01_RS00250	COG2022	thiamine diphosphate biosynthetic process
Vp2S01_RS00260	COG0006	proline dipeptidase activity
Vp2S01_RS00260	COG0006	proline dipeptidase activity
Vp2S01_RS00290	COG3220	belongs to the UPF0276 family
Vp2S01_RS00300	COG0210	DNA helicase
Vp2S01_RS00310	COG0405	Gamma-glutamyltransferase
Vp2S01_RS00315	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_RS00325	COG2962	Rard protein
Vp2S01_RS00330	COG0514	ATP-dependent DNA helicase (RecQ)
Vp2S01_RS00345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Vp2S01_RS00350	COG0248	Ppx GppA phosphatase
Vp2S01_RS00355	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS00360	COG3118	belongs to the thioredoxin family
Vp2S01_RS00380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Vp2S01_RS00385	COG0633	Ferredoxin
Vp2S01_RS00440	COG3071	HemY protein
Vp2S01_RS00445	COG2959	enzyme of heme biosynthesis
Vp2S01_RS00450	COG1587	Uroporphyrinogen-III synthase
Vp2S01_RS00455	COG0181	hydroxymethylbilane synthase activity
Vp2S01_RS00460	COG3072	Adenylate cyclase
Vp2S01_RS00465	COG1965	Belongs to the frataxin family
Vp2S01_RS00475	COG0019	diaminopimelate decarboxylase activity
Vp2S01_RS00480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Vp2S01_RS00490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Vp2S01_RS00495	COG1011	Hydrolase
Vp2S01_RS00500	COG3287	FIST C domain
Vp2S01_RS00500	COG2200	EAL domain
Vp2S01_RS00500	COG2199	diguanylate cyclase activity
Vp2S01_RS00505	COG3148	PFAM DTW domain containing protein
Vp2S01_RS00520	COG0561	phosphatase activity
Vp2S01_RS00530	COG2267	carboxylic ester hydrolase activity
Vp2S01_RS00535	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_RS00540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Vp2S01_RS00545	COG0640	Transcriptional regulator
Vp2S01_RS00550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vp2S01_RS00605	COG2095	MarC family integral membrane protein
Vp2S01_RS00615	COG0742	ribosomal rna small subunit methyltransferase
Vp2S01_RS00620	COG0552	protein localization to endoplasmic reticulum
Vp2S01_RS00625	COG2884	Cell division ATP-binding protein ftsE
Vp2S01_RS00630	COG2177	Part of the ABC transporter FtsEX involved in
Vp2S01_RS00645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vp2S01_RS00650	COG0705	Rhomboid family
Vp2S01_RS00655	COG1580	Controls the rotational direction of flagella during chemotaxis
Vp2S01_RS00660	COG3161	chorismate lyase activity
Vp2S01_RS00665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Vp2S01_RS00670	COG2937	Belongs to the GPAT DAPAT family
Vp2S01_RS00680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Vp2S01_RS00685	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Vp2S01_RS00690	COG0534	Mate efflux family protein
Vp2S01_RS00695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vp2S01_RS00710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Vp2S01_RS00715	COG4206	TonB-dependent receptor
Vp2S01_RS00725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Vp2S01_RS00790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vp2S01_RS00800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Vp2S01_RS00835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vp2S01_RS00845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Vp2S01_RS00850	COG0250	Participates in transcription elongation, termination and antitermination
Vp2S01_RS00855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Vp2S01_RS00860	COG0081	regulation of translation
Vp2S01_RS00865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Vp2S01_RS00870	COG0222	ribosome binding
Vp2S01_RS00875	COG0085	RNA polymerase activity
Vp2S01_RS00880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vp2S01_RS00885	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Vp2S01_RS00890	COG2816	NAD+ diphosphatase activity
Vp2S01_RS00905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Vp2S01_RS00910	COG1573	uracil-dna glycosylase
Vp2S01_RS00915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vp2S01_RS00925	COG1253	flavin adenine dinucleotide binding
Vp2S01_RS00940	COG0151	Belongs to the GarS family
Vp2S01_RS00950	COG0138	bifunctional purine biosynthesis protein purh
Vp2S01_RS00960	COG0789	Transcriptional regulator
Vp2S01_RS00965	COG3710	Transcriptional regulator
Vp2S01_RS00975	COG0531	amino acid
Vp2S01_RS00980	COG1982	Orn Lys Arg decarboxylase major
Vp2S01_RS01040	COG3706	GGDEF domain
Vp2S01_RS01045	COG0488	(ABC) transporter
Vp2S01_RS01050	COG2814	Major facilitator Superfamily
Vp2S01_RS01055	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Vp2S01_RS01060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Vp2S01_RS01065	COG2264	protein methyltransferase activity
Vp2S01_RS01075	COG0439	Biotin carboxylase
Vp2S01_RS01080	COG0511	ligase activity, forming carbon-carbon bonds
Vp2S01_RS01085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Vp2S01_RS01090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vp2S01_RS01105	COG2814	Major facilitator Superfamily
Vp2S01_RS01110	COG0784	Response regulator, receiver
Vp2S01_RS01110	COG2198	Histidine kinase
Vp2S01_RS01110	COG2205	protein histidine kinase activity
Vp2S01_RS01135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vp2S01_RS01145	COG3263	regulation of cellular component size
Vp2S01_RS01155	COG4232	protein-disulfide reductase activity
Vp2S01_RS01160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Vp2S01_RS01165	COG1027	Aspartate ammonia-lyase
Vp2S01_RS01170	COG3030	protein affecting phage T7 exclusion by the F plasmid
Vp2S01_RS01175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Vp2S01_RS01185	COG2205	protein histidine kinase activity
Vp2S01_RS01190	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS01200	COG3678	ATP-independent chaperone mediated protein folding
Vp2S01_RS01210	COG0205	6-phosphofructokinase activity
Vp2S01_RS01215	COG0534	Mate efflux family protein
Vp2S01_RS01225	COG0459	protein refolding
Vp2S01_RS01240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vp2S01_RS01250	COG1509	lysine 2,3-aminomutase activity
Vp2S01_RS01255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Vp2S01_RS01265	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Vp2S01_RS01270	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Vp2S01_RS01275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Vp2S01_RS01280	COG1053	succinate dehydrogenase
Vp2S01_RS01290	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Vp2S01_RS01310	COG4942	peptidase
Vp2S01_RS01315	COG1045	serine acetyltransferase
Vp2S01_RS01320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Vp2S01_RS01325	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Vp2S01_RS01330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vp2S01_RS01335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Vp2S01_RS01350	COG0471	metal ion transport
Vp2S01_RS01355	COG0688	phosphatidylethanolamine metabolic process
Vp2S01_RS01360	COG1162	GTPase activity
Vp2S01_RS01365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Vp2S01_RS01435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Vp2S01_RS01440	COG0802	atpase or kinase
Vp2S01_RS01450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Vp2S01_RS01455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Vp2S01_RS01465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Vp2S01_RS01470	COG0330	HflC and HflK could
Vp2S01_RS01475	COG0330	HflC and HflK could
Vp2S01_RS01480	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Vp2S01_RS01485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vp2S01_RS01495	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
Vp2S01_RS01500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vp2S01_RS01500	COG1017	nitric oxide dioxygenase activity
Vp2S01_RS01505	COG1959	2 iron, 2 sulfur cluster binding
Vp2S01_RS01510	COG0557	exoribonuclease II activity
Vp2S01_RS01515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vp2S01_RS01520	COG0546	phosphoglycolate phosphatase activity
Vp2S01_RS01525	COG0180	Tryptophanyl-tRNA synthetase
Vp2S01_RS01560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Vp2S01_RS01570	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_RS01580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vp2S01_RS01585	COG3954	Phosphoribulokinase
Vp2S01_RS01590	COG3089	Belongs to the UPF0270 family
Vp2S01_RS01595	COG0429	hydrolase of the alpha beta-hydrolase fold
Vp2S01_RS01605	COG0488	(ABC) transporter
Vp2S01_RS01615	COG2249	NAD(P)H dehydrogenase (quinone) activity
Vp2S01_RS01630	COG1047	Peptidyl-prolyl cis-trans
Vp2S01_RS01640	COG1446	asparaginase
Vp2S01_RS01645	COG2900	Belongs to the SlyX family
Vp2S01_RS01655	COG0545	Peptidyl-prolyl cis-trans isomerase
Vp2S01_RS01660	COG2964	Protein conserved in bacteria
Vp2S01_RS01665	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Vp2S01_RS01670	COG2923	Belongs to the DsrF TusC family
Vp2S01_RS01675	COG2168	tRNA wobble position uridine thiolation
Vp2S01_RS01685	COG0049	tRNA binding
Vp2S01_RS01690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vp2S01_RS01695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vp2S01_RS01700	COG2906	2 iron, 2 sulfur cluster binding
Vp2S01_RS01710	COG0281	malic enzyme
Vp2S01_RS01720	COG0626	cystathionine gamma-synthase activity
Vp2S01_RS01725	COG0460	homoserine dehydrogenase
Vp2S01_RS01725	COG0527	aspartate kinase activity
Vp2S01_RS01730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Vp2S01_RS01740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Vp2S01_RS01745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vp2S01_RS01750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Vp2S01_RS01755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vp2S01_RS01760	COG0137	argininosuccinate synthase activity
Vp2S01_RS01765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vp2S01_RS01765	COG0165	Argininosuccinate lyase
Vp2S01_RS01780	COG0678	peroxiredoxin activity
Vp2S01_RS01780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Vp2S01_RS01790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Vp2S01_RS01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Vp2S01_RS01825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Vp2S01_RS01835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Vp2S01_RS01840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Vp2S01_RS01845	COG0360	Binds together with S18 to 16S ribosomal RNA
Vp2S01_RS01850	COG2965	DNA replication, synthesis of RNA primer
Vp2S01_RS01860	COG0359	binds to the 23S rRNA
Vp2S01_RS01875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vp2S01_RS01885	COG0432	Pfam Uncharacterised protein family UPF0047
Vp2S01_RS01890	COG0166	Belongs to the GPI family
Vp2S01_RS01900	COG0735	belongs to the Fur family
Vp2S01_RS01910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Vp2S01_RS01935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Vp2S01_RS01940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vp2S01_RS01945	COG0175	sulfate reduction
Vp2S01_RS02010	COG3335	DDE superfamily endonuclease
Vp2S01_RS02025	COG1410	methionine synthase
Vp2S01_RS02025	COG0646	methionine synthase
Vp2S01_RS02030	COG0527	aspartate kinase activity
Vp2S01_RS02040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Vp2S01_RS02050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Vp2S01_RS02065	COG0629	single-stranded DNA binding
Vp2S01_RS02070	COG2200	EAL domain
Vp2S01_RS02070	COG2199	diguanylate cyclase activity
Vp2S01_RS02095	COG3409	Peptidoglycan-binding domain 1 protein
Vp2S01_RS02095	COG3267	Type II secretory pathway component ExeA
Vp2S01_RS02105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vp2S01_RS02110	COG1459	type II secretion system
Vp2S01_RS02155	COG1077	Cell shape determining protein MreB Mrl
Vp2S01_RS02160	COG1792	Involved in formation and maintenance of cell shape
Vp2S01_RS02165	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Vp2S01_RS02170	COG0424	maF-like protein
Vp2S01_RS02180	COG3164	Protein of unknown function
Vp2S01_RS02185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vp2S01_RS02190	COG0312	modulator of DNA gyrase
Vp2S01_RS02195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Vp2S01_RS02200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Vp2S01_RS02215	COG0564	pseudouridine synthase activity
Vp2S01_RS02220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vp2S01_RS02225	COG3028	Belongs to the UPF0307 family
Vp2S01_RS02230	COG0312	modulator of DNA gyrase
Vp2S01_RS02235	COG2239	Acts as a magnesium transporter
Vp2S01_RS02240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_RS02245	COG1660	Displays ATPase and GTPase activities
Vp2S01_RS02250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_RS02255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Vp2S01_RS02265	COG1137	ATPase activity
Vp2S01_RS02270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Vp2S01_RS02280	COG0517	IMP dehydrogenase activity
Vp2S01_RS02280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vp2S01_RS02290	COG1127	ABC transporter
Vp2S01_RS02295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Vp2S01_RS02300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Vp2S01_RS02305	COG2854	intermembrane phospholipid transfer
Vp2S01_RS02315	COG5007	Belongs to the BolA IbaG family
Vp2S01_RS02320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Vp2S01_RS02325	COG0204	Acyl-transferase
Vp2S01_RS02330	COG0251	oxidation-reduction process
Vp2S01_RS02335	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Vp2S01_RS02340	COG0540	Belongs to the ATCase OTCase family
Vp2S01_RS02350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Vp2S01_RS02355	COG2235	arginine
Vp2S01_RS02385	COG0525	valine-tRNA ligase activity
Vp2S01_RS02390	COG2927	DNA polymerase III (CHI subunit)
Vp2S01_RS02395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Vp2S01_RS02400	COG0795	lipopolysaccharide-transporting ATPase activity
Vp2S01_RS02405	COG0795	lipopolysaccharide-transporting ATPase activity
Vp2S01_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS02450	COG0726	polysaccharide deacetylase
Vp2S01_RS02455	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Vp2S01_RS02460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Vp2S01_RS02465	COG1447	Phosphotransferase system cellobiose-specific component IIA
Vp2S01_RS02470	COG1486	melibiose metabolic process
Vp2S01_RS02475	COG3394	polysaccharide catabolic process
Vp2S01_RS02485	COG3437	response regulator, receiver
Vp2S01_RS02535	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_RS02605	COG0741	lytic transglycosylase activity
Vp2S01_RS02610	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Vp2S01_RS02620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Vp2S01_RS02630	COG2066	Belongs to the glutaminase family
Vp2S01_RS02635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Vp2S01_RS02640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Vp2S01_RS02650	COG1872	DUF167
Vp2S01_RS02655	COG0762	integral membrane protein
Vp2S01_RS02660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Vp2S01_RS02665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Vp2S01_RS02680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Vp2S01_RS02685	COG1678	Uncharacterized ACR, COG1678
Vp2S01_RS02690	COG0189	ligase activity
Vp2S01_RS02695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Vp2S01_RS02700	COG2356	endonuclease I
Vp2S01_RS02705	COG3091	SprT-like family
Vp2S01_RS02715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Vp2S01_RS02725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Vp2S01_RS02730	COG0583	DNA-binding transcription factor activity
Vp2S01_RS02735	COG4771	TonB-dependent receptor
Vp2S01_RS02740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vp2S01_RS02745	COG0126	phosphoglycerate kinase activity
Vp2S01_RS02750	COG0191	fructose-bisphosphate aldolase activity
Vp2S01_RS02755	COG0668	transmembrane transport
Vp2S01_RS02760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Vp2S01_RS02770	COG0583	DNA-binding transcription factor activity
Vp2S01_RS02780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vp2S01_RS02785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Vp2S01_RS02790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Vp2S01_RS02800	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Vp2S01_RS02810	COG3079	Belongs to the UPF0149 family
Vp2S01_RS02815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vp2S01_RS02820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vp2S01_RS02835	COG0354	folic acid binding
Vp2S01_RS02840	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Vp2S01_RS02850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Vp2S01_RS02860	COG1595	DNA-templated transcription, initiation
Vp2S01_RS02865	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
Vp2S01_RS02875	COG3086	response to oxidative stress
Vp2S01_RS02880	COG0481	GTPase activity
Vp2S01_RS02890	COG0571	ribonuclease III activity
Vp2S01_RS02895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Vp2S01_RS02900	COG1381	Involved in DNA repair and RecF pathway recombination
Vp2S01_RS02905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Vp2S01_RS02910	COG0736	holo-[acyl-carrier-protein] synthase activity
Vp2S01_RS02920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Vp2S01_RS02930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vp2S01_RS02935	COG3956	TIGRFAM MazG family protein
Vp2S01_RS02940	COG0504	CTP synthase activity
Vp2S01_RS02945	COG0148	phosphopyruvate hydratase activity
Vp2S01_RS02950	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Vp2S01_RS02955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Vp2S01_RS02960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Vp2S01_RS02965	COG0585	pseudouridine synthase activity
Vp2S01_RS02970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Vp2S01_RS02975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vp2S01_RS02990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Vp2S01_RS02995	COG1546	Belongs to the CinA family
Vp2S01_RS03000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Vp2S01_RS03005	COG2137	regulation of response to DNA damage stimulus
Vp2S01_RS03010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vp2S01_RS03015	COG0527	aspartate kinase activity
Vp2S01_RS03075	COG3630	sodium ion export across plasma membrane
Vp2S01_RS03080	COG0511	ligase activity, forming carbon-carbon bonds
Vp2S01_RS03080	COG5016	pyruvate
Vp2S01_RS03085	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Vp2S01_RS03095	COG1238	metal cluster binding
Vp2S01_RS03100	COG0612	Peptidase, M16
Vp2S01_RS03105	COG2918	glutathione biosynthetic process
Vp2S01_RS03115	COG1854	S-ribosylhomocysteine lyase activity
Vp2S01_RS03120	COG4536	flavin adenine dinucleotide binding
Vp2S01_RS03125	COG4137	Cytochrome C assembly protein
Vp2S01_RS03130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vp2S01_RS03135	COG0228	four-way junction DNA binding
Vp2S01_RS03140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Vp2S01_RS03145	COG0336	Belongs to the RNA methyltransferase TrmD family
Vp2S01_RS03150	COG0335	large ribosomal subunit rRNA binding
Vp2S01_RS03155	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Vp2S01_RS03160	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Vp2S01_RS03165	COG0237	dephospho-CoA kinase activity
Vp2S01_RS03175	COG1459	type II secretion system
Vp2S01_RS03180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vp2S01_RS03195	COG0157	Belongs to the NadC ModD family
Vp2S01_RS03205	COG2186	Transcriptional regulator
Vp2S01_RS03210	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Vp2S01_RS03215	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vp2S01_RS03220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vp2S01_RS03235	COG0288	reversible hydration of carbon dioxide
Vp2S01_RS03240	COG0659	secondary active sulfate transmembrane transporter activity
Vp2S01_RS03250	COG1131	(ABC) transporter
Vp2S01_RS03255	COG0842	Transport permease protein
Vp2S01_RS03265	COG1560	Kdo2-lipid A biosynthetic process
Vp2S01_RS03275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Vp2S01_RS03280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Vp2S01_RS03285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Vp2S01_RS03300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vp2S01_RS03315	COG1489	DNA binding
Vp2S01_RS03320	COG1643	Atp-dependent helicase
Vp2S01_RS03325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Vp2S01_RS03330	COG1752	Esterase of the alpha-beta hydrolase superfamily
Vp2S01_RS03335	COG1049	propionate catabolic process, 2-methylcitrate cycle
Vp2S01_RS03340	COG3112	Uncharacterised protein family (UPF0231)
Vp2S01_RS03350	COG0004	ammonium transporteR
Vp2S01_RS03355	COG1840	ABC-type Fe3 transport system, periplasmic component
Vp2S01_RS03365	COG3842	ATPase activity
Vp2S01_RS03370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vp2S01_RS03385	COG2971	BadF BadG BcrA BcrD
Vp2S01_RS03395	COG4608	Belongs to the ABC transporter superfamily
Vp2S01_RS03400	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_RS03405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vp2S01_RS03415	COG0747	negative chemotaxis
Vp2S01_RS03420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_RS03420	COG2198	Histidine kinase
Vp2S01_RS03420	COG2205	protein histidine kinase activity
Vp2S01_RS03420	COG0784	Response regulator, receiver
Vp2S01_RS03430	COG2813	Specifically methylates the guanine in position
Vp2S01_RS03435	COG0628	permease
Vp2S01_RS03440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vp2S01_RS03445	COG0316	Belongs to the HesB IscA family
Vp2S01_RS03455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_RS03460	COG0739	heme binding
Vp2S01_RS03465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Vp2S01_RS03475	COG2027	D-alanyl-D-alanine carboxypeptidase
Vp2S01_RS03480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Vp2S01_RS03485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vp2S01_RS03490	COG1534	Rna-binding protein
Vp2S01_RS03495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Vp2S01_RS03500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vp2S01_RS03505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Vp2S01_RS03510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vp2S01_RS03520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Vp2S01_RS03535	COG0779	Required for maturation of 30S ribosomal subunits
Vp2S01_RS03540	COG0195	Participates in both transcription termination and antitermination
Vp2S01_RS03545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Vp2S01_RS03550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Vp2S01_RS03555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Vp2S01_RS03560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Vp2S01_RS03565	COG1185	polyribonucleotide nucleotidyltransferase activity
Vp2S01_RS03580	COG0534	Mate efflux family protein
Vp2S01_RS03585	COG0826	peptidase U32
Vp2S01_RS03590	COG0826	peptidase U32
Vp2S01_RS03600	COG3154	lipid carrier protein
Vp2S01_RS03605	COG3153	acetyltransferase
Vp2S01_RS03625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Vp2S01_RS03635	COG0084	hydrolase, TatD family'
Vp2S01_RS03640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Vp2S01_RS03645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Vp2S01_RS03650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Vp2S01_RS03655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Vp2S01_RS03660	COG0813	purine-nucleoside phosphorylase activity
Vp2S01_RS03670	COG0560	Phosphoserine phosphatase
Vp2S01_RS03680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Vp2S01_RS03685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vp2S01_RS03690	COG0583	DNA-binding transcription factor activity
Vp2S01_RS03700	COG1022	Amp-dependent synthetase and ligase
Vp2S01_RS03705	COG2169	Transcriptional regulator
Vp2S01_RS03730	COG4964	Belongs to the GSP D family
Vp2S01_RS03790	COG0583	DNA-binding transcription factor activity
Vp2S01_RS03795	COG0531	amino acid
Vp2S01_RS03800	COG2731	YhcH YjgK YiaL family protein
Vp2S01_RS03805	COG3250	beta-galactosidase activity
Vp2S01_RS03810	COG1609	Transcriptional regulator
Vp2S01_RS03820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Vp2S01_RS03830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Vp2S01_RS03835	COG2017	converts alpha-aldose to the beta-anomer
Vp2S01_RS03850	COG2211	Major facilitator Superfamily
Vp2S01_RS03855	COG1609	Transcriptional regulator
Vp2S01_RS03860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vp2S01_RS03875	COG0598	Magnesium transport protein CorA
Vp2S01_RS03880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Vp2S01_RS03885	COG1349	DNA-binding transcription factor activity
Vp2S01_RS03890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Vp2S01_RS03895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Vp2S01_RS03910	COG2271	Major facilitator Superfamily
Vp2S01_RS03915	COG0584	glycerophosphoryl diester phosphodiesterase
Vp2S01_RS03920	COG2171	N-acyltransferase activity
Vp2S01_RS03925	COG3141	response to X-ray
Vp2S01_RS03945	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Vp2S01_RS03955	COG1074	ATP-dependent DNA helicase activity
Vp2S01_RS03960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Vp2S01_RS03970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vp2S01_RS03970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vp2S01_RS03985	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Vp2S01_RS03990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Vp2S01_RS03995	COG2166	iron-sulfur cluster assembly
Vp2S01_RS04000	COG3706	GGDEF domain
Vp2S01_RS04005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vp2S01_RS04010	COG0693	protein deglycase activity
Vp2S01_RS04015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vp2S01_RS04045	COG1595	DNA-templated transcription, initiation
Vp2S01_RS04065	COG3056	Lipoprotein
Vp2S01_RS04070	COG2813	Specifically methylates the guanine in position
Vp2S01_RS04075	COG0271	Belongs to the BolA IbaG family
Vp2S01_RS04085	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vp2S01_RS04090	COG1805	sodium ion transport
Vp2S01_RS04095	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vp2S01_RS04100	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vp2S01_RS04105	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vp2S01_RS04110	COG2871	sodium ion transport
Vp2S01_RS04115	COG1477	protein flavinylation
Vp2S01_RS04130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vp2S01_RS04135	COG0514	ATP-dependent DNA helicase (RecQ)
Vp2S01_RS04140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vp2S01_RS04155	COG0733	neurotransmitter:sodium symporter activity
Vp2S01_RS04175	COG0442	prolyl-tRNA aminoacylation
Vp2S01_RS04180	COG1720	tRNA m6t6A37 methyltransferase activity
Vp2S01_RS04185	COG0254	rRNA binding
Vp2S01_RS04200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Vp2S01_RS04205	COG1671	Belongs to the UPF0178 family
Vp2S01_RS04230	COG3098	single-species biofilm formation
Vp2S01_RS04235	COG0564	pseudouridine synthase activity
Vp2S01_RS04245	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Vp2S01_RS04250	COG0024	Methionine aminopeptidase
Vp2S01_RS04255	COG0052	Belongs to the universal ribosomal protein uS2 family
Vp2S01_RS04260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Vp2S01_RS04265	COG0528	UMP kinase activity
Vp2S01_RS04270	COG0233	cytoplasmic translational termination
Vp2S01_RS04275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Vp2S01_RS04280	COG0575	Belongs to the CDS family
Vp2S01_RS04285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Vp2S01_RS04290	COG0750	zinc metalloprotease
Vp2S01_RS04300	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Vp2S01_RS04305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vp2S01_RS04310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vp2S01_RS04315	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vp2S01_RS04320	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vp2S01_RS04325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Vp2S01_RS04330	COG0587	DNA-directed DNA polymerase activity
Vp2S01_RS04335	COG0825	malonyl-CoA metabolic process
Vp2S01_RS04340	COG0037	tRNA processing
Vp2S01_RS04350	COG0347	Belongs to the P(II) protein family
Vp2S01_RS04355	COG3021	interspecies interaction between organisms
Vp2S01_RS04365	COG0741	lytic transglycosylase activity
Vp2S01_RS04365	COG1388	LysM domain
Vp2S01_RS04370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vp2S01_RS04375	COG2226	methyltransferase
Vp2S01_RS04380	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_RS04385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Vp2S01_RS04400	COG1960	acyl-CoA dehydrogenase activity
Vp2S01_RS04405	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Vp2S01_RS04410	COG0121	glutamine amidotransferase
Vp2S01_RS04415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Vp2S01_RS04420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Vp2S01_RS04425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Vp2S01_RS04430	COG2233	PERMEase
Vp2S01_RS04450	COG1393	Belongs to the ArsC family
Vp2S01_RS04455	COG4783	chaperone-mediated protein folding
Vp2S01_RS04470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Vp2S01_RS04475	COG2716	regulation of RNA biosynthetic process
Vp2S01_RS04480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vp2S01_RS04485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Vp2S01_RS04500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vp2S01_RS04505	COG1393	Belongs to the ArsC family
Vp2S01_RS04535	COG2837	iron assimilation
Vp2S01_RS04540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS04550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS04555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS04560	COG1334	flagellar protein FlaG
Vp2S01_RS04565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Vp2S01_RS04575	COG1516	flagellar protein fliS
Vp2S01_RS04595	COG1677	Flagellar hook-basal body complex protein FliE
Vp2S01_RS04605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Vp2S01_RS04655	COG1987	bacterial-type flagellum assembly
Vp2S01_RS04660	COG1684	flagellar biosynthetic protein fliR
Vp2S01_RS04695	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Vp2S01_RS04700	COG0643	Histidine kinase
Vp2S01_RS04700	COG2198	Histidine kinase
Vp2S01_RS04700	COG0784	Response regulator, receiver
Vp2S01_RS04705	COG2201	protein-glutamate methylesterase activity
Vp2S01_RS04710	COG1192	Involved in chromosome partitioning
Vp2S01_RS04720	COG0835	chemotaxis
Vp2S01_RS04730	COG4133	protoheme IX ABC transporter activity
Vp2S01_RS04735	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vp2S01_RS04740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vp2S01_RS04745	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vp2S01_RS04750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Vp2S01_RS04755	COG1138	Cytochrome C-type biogenesis protein
Vp2S01_RS04760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Vp2S01_RS04775	COG2853	Lipoprotein
Vp2S01_RS04785	COG2067	long-chain fatty acid transport protein
Vp2S01_RS04805	COG0183	Belongs to the thiolase family
Vp2S01_RS04810	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vp2S01_RS04810	COG1024	Enoyl-CoA hydratase
Vp2S01_RS04825	COG2062	phosphohistidine phosphatase, SixA
Vp2S01_RS04830	COG2840	Smr protein MutS2
Vp2S01_RS04835	COG2890	protein-(glutamine-N5) methyltransferase activity
Vp2S01_RS04840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Vp2S01_RS04845	COG2860	membrane
Vp2S01_RS04855	COG3101	peptidyl-lysine hydroxylation
Vp2S01_RS04870	COG0431	NADPH-dependent FMN reductase
Vp2S01_RS04875	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Vp2S01_RS04875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vp2S01_RS04880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vp2S01_RS04890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vp2S01_RS04895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vp2S01_RS04905	COG0101	tRNA pseudouridine synthase activity
Vp2S01_RS04910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Vp2S01_RS04915	COG0285	dihydrofolate synthase activity
Vp2S01_RS04920	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Vp2S01_RS04925	COG1286	toxin biosynthetic process
Vp2S01_RS04930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vp2S01_RS04935	COG0583	DNA-binding transcription factor activity
Vp2S01_RS04940	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS04950	COG2832	Protein of unknown function (DUF454)
Vp2S01_RS04955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Vp2S01_RS04965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Vp2S01_RS04970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Vp2S01_RS04975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Vp2S01_RS04980	COG0814	amino acid
Vp2S01_RS04985	COG0251	oxidation-reduction process
Vp2S01_RS04990	COG3681	Belongs to the UPF0597 family
Vp2S01_RS05005	COG2261	transglycosylase associated protein
Vp2S01_RS05010	COG2983	Belongs to the UPF0260 family
Vp2S01_RS05015	COG0668	transmembrane transport
Vp2S01_RS05020	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Vp2S01_RS05025	COG0346	lactoylglutathione lyase activity
Vp2S01_RS05035	COG1785	Belongs to the alkaline phosphatase family
Vp2S01_RS05055	COG2226	methyltransferase
Vp2S01_RS05070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vp2S01_RS05075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vp2S01_RS05085	COG3139	Protein of unknown function (DUF1315)
Vp2S01_RS05090	COG0252	asparaginase activity
Vp2S01_RS05095	COG0616	signal peptide processing
Vp2S01_RS05100	COG1902	pentaerythritol trinitrate reductase activity
Vp2S01_RS05100	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vp2S01_RS05105	COG0778	Nitroreductase
Vp2S01_RS05110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vp2S01_RS05130	COG0123	including yeast histone deacetylase and acetoin utilization protein
Vp2S01_RS05185	COG3083	sulfuric ester hydrolase activity
Vp2S01_RS05190	COG3082	Protein of unknown function (DUF1414)
Vp2S01_RS05195	COG3081	Nucleoid-associated protein
Vp2S01_RS05210	COG1757	Na H antiporter
Vp2S01_RS05215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vp2S01_RS05220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vp2S01_RS05225	COG2095	MarC family integral membrane protein
Vp2S01_RS05230	COG1454	alcohol dehydrogenase
Vp2S01_RS05230	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_RS05250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Vp2S01_RS05260	COG2056	Na+-H+ antiporter family
Vp2S01_RS05265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Vp2S01_RS05280	COG2885	chlorophyll binding
Vp2S01_RS05290	COG0346	lactoylglutathione lyase activity
Vp2S01_RS05295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vp2S01_RS05300	COG4660	Part of a membrane complex involved in electron transport
Vp2S01_RS05305	COG4659	FMN binding
Vp2S01_RS05310	COG4658	electron transport chain
Vp2S01_RS05315	COG4656	Part of a membrane complex involved in electron transport
Vp2S01_RS05320	COG2878	Part of a membrane complex involved in electron transport
Vp2S01_RS05325	COG4657	Part of a membrane complex involved in electron transport
Vp2S01_RS05340	COG0556	nucleotide-excision repair
Vp2S01_RS05345	COG2204	response regulator
Vp2S01_RS05350	COG2198	Histidine kinase
Vp2S01_RS05355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Vp2S01_RS05360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vp2S01_RS05365	COG0521	Mo-molybdopterin cofactor biosynthetic process
Vp2S01_RS05370	COG0315	cyclic pyranopterin monophosphate synthase activity
Vp2S01_RS05375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Vp2S01_RS05380	COG0314	molybdopterin synthase activity
Vp2S01_RS05390	COG0601	transmembrane transport
Vp2S01_RS05395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vp2S01_RS05400	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_RS05410	COG0435	Glutathione S-transferase
Vp2S01_RS05420	COG3174	membrane
Vp2S01_RS05425	COG0280	phosphate acetyltransferase
Vp2S01_RS05425	COG0857	belongs to the CobB CobQ family
Vp2S01_RS05430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Vp2S01_RS05435	COG3092	negative regulation of chromosome organization
Vp2S01_RS05445	COG4120	Belongs to the binding-protein-dependent transport system permease family
Vp2S01_RS05450	COG1122	ATPase activity
Vp2S01_RS05455	COG0366	Alpha amylase catalytic
Vp2S01_RS05465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Vp2S01_RS05470	COG3012	SEC-C Motif Domain Protein
Vp2S01_RS05470	COG3318	Belongs to the UPF0149 family
Vp2S01_RS05475	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Vp2S01_RS05480	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vp2S01_RS05485	COG2186	Transcriptional regulator
Vp2S01_RS05495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vp2S01_RS05495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vp2S01_RS05500	COG0489	protein tyrosine kinase activity
Vp2S01_RS05505	COG0572	uridine kinase
Vp2S01_RS05515	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Vp2S01_RS05520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Vp2S01_RS05525	COG0659	secondary active sulfate transmembrane transporter activity
Vp2S01_RS05535	COG1530	ribonuclease E activity
Vp2S01_RS05550	COG0564	pseudouridine synthase activity
Vp2S01_RS05555	COG0424	maF-like protein
Vp2S01_RS05560	COG1399	metal-binding, possibly nucleic acid-binding protein
Vp2S01_RS05570	COG0416	fatty acid biosynthetic process
Vp2S01_RS05575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vp2S01_RS05605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Vp2S01_RS05610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Vp2S01_RS05620	COG0084	hydrolase, TatD family'
Vp2S01_RS05625	COG1263	PTS System
Vp2S01_RS05625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_RS05645	COG0733	neurotransmitter:sodium symporter activity
Vp2S01_RS05660	COG4667	esterase of the alpha-beta hydrolase superfamily
Vp2S01_RS05665	COG0469	pyruvate kinase activity
Vp2S01_RS05670	COG1940	carbohydrate kinase activity
Vp2S01_RS05675	COG0835	chemotaxis
Vp2S01_RS05675	COG0784	Response regulator, receiver
Vp2S01_RS05680	COG0587	DNA-directed DNA polymerase activity
Vp2S01_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS05700	COG0616	signal peptide processing
Vp2S01_RS05705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Vp2S01_RS05710	COG0539	negative regulation of cytoplasmic translation
Vp2S01_RS05720	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Vp2S01_RS05725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Vp2S01_RS05730	COG0284	orotidine-5'-phosphate decarboxylase activity
Vp2S01_RS05735	COG4166	transmembrane transport
Vp2S01_RS05760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Vp2S01_RS05770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Vp2S01_RS05770	COG3008	intermembrane lipid transfer
Vp2S01_RS05775	COG2995	paraquat-inducible protein a
Vp2S01_RS05780	COG3258	Cytochrome c
Vp2S01_RS05785	COG2863	cytochrome
Vp2S01_RS05825	COG4232	protein-disulfide reductase activity
Vp2S01_RS05830	COG3118	belongs to the thioredoxin family
Vp2S01_RS05850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_RS05860	COG1136	(ABC) transporter
Vp2S01_RS05860	COG0577	efflux transmembrane transporter activity
Vp2S01_RS05870	COG1136	(ABC) transporter
Vp2S01_RS05870	COG0577	efflux transmembrane transporter activity
Vp2S01_RS05875	COG1335	isochorismatase
Vp2S01_RS05925	COG3850	Histidine kinase
Vp2S01_RS05925	COG5002	protein histidine kinase activity
Vp2S01_RS05930	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS05940	COG0840	transmembrane signaling receptor activity
Vp2S01_RS05945	COG1032	radical SAM domain protein
Vp2S01_RS05950	COG3706	GGDEF domain
Vp2S01_RS05950	COG5001	Diguanylate cyclase
Vp2S01_RS05950	COG4251	negative regulation of phosphorylation
Vp2S01_RS05950	COG2203	Gaf domain
Vp2S01_RS05965	COG0583	DNA-binding transcription factor activity
Vp2S01_RS05975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vp2S01_RS05985	COG2350	Protein conserved in bacteria
Vp2S01_RS05995	COG2917	probably involved in intracellular septation
Vp2S01_RS06015	COG1301	dicarboxylic acid transport
Vp2S01_RS06025	COG0318	PFAM AMP-dependent synthetase and ligase
Vp2S01_RS06030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vp2S01_RS06035	COG0159	tryptophan synthase activity
Vp2S01_RS06040	COG0133	tryptophan synthase activity
Vp2S01_RS06045	COG0134	indole-3-glycerol-phosphate synthase activity
Vp2S01_RS06045	COG0135	phosphoribosylanthranilate isomerase activity
Vp2S01_RS06050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vp2S01_RS06055	COG0512	Glutamine amidotransferase of anthranilate synthase
Vp2S01_RS06060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vp2S01_RS06070	COG0613	PHP domain protein
Vp2S01_RS06075	COG0009	L-threonylcarbamoyladenylate synthase
Vp2S01_RS06085	COG1187	pseudouridine synthase activity
Vp2S01_RS06095	COG3099	Belongs to the UPF0263 family
Vp2S01_RS06100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Vp2S01_RS06110	COG0417	DNA replication proofreading
Vp2S01_RS06115	COG2197	response regulator
Vp2S01_RS06120	COG0322	excinuclease ABC activity
Vp2S01_RS06160	COG0019	diaminopimelate decarboxylase activity
Vp2S01_RS06185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vp2S01_RS06190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vp2S01_RS06195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vp2S01_RS06215	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Vp2S01_RS06225	COG0437	4 iron, 4 sulfur cluster binding
Vp2S01_RS06230	COG3301	Polysulphide reductase, NrfD
Vp2S01_RS06235	COG1138	Cytochrome C-type biogenesis protein
Vp2S01_RS06245	COG4235	cytochrome complex assembly
Vp2S01_RS06245	COG3088	subunit of a heme lyase
Vp2S01_RS06255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vp2S01_RS06280	COG2989	Protein conserved in bacteria
Vp2S01_RS06285	COG3108	Peptidase M15
Vp2S01_RS06290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vp2S01_RS06305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Vp2S01_RS06330	COG1846	Transcriptional regulator
Vp2S01_RS06335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_RS06340	COG0840	transmembrane signaling receptor activity
Vp2S01_RS06360	COG1448	Aminotransferase
Vp2S01_RS06385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_RS06395	COG0017	Asparaginyl-tRNA synthetase
Vp2S01_RS06405	COG0720	synthase
Vp2S01_RS06415	COG2200	EAL domain
Vp2S01_RS06420	COG1760	l-serine dehydratase
Vp2S01_RS06425	COG0814	amino acid
Vp2S01_RS06430	COG0494	nUDIX hydrolase
Vp2S01_RS06440	COG0784	Response regulator, receiver
Vp2S01_RS06440	COG2205	protein histidine kinase activity
Vp2S01_RS06445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vp2S01_RS06465	COG3106	COG3106 Predicted ATPase
Vp2S01_RS06470	COG3768	UPF0283 membrane protein
Vp2S01_RS06480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vp2S01_RS06630	COG0494	nUDIX hydrolase
Vp2S01_RS06700	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_RS06905	COG0251	oxidation-reduction process
Vp2S01_RS07130	COG1335	isochorismatase
Vp2S01_RS07185	COG0494	nUDIX hydrolase
Vp2S01_RS07275	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_RS07395	COG0346	lactoylglutathione lyase activity
Vp2S01_RS07515	COG1683	Conserved Protein
Vp2S01_RS07580	COG0346	lactoylglutathione lyase activity
Vp2S01_RS07590	COG0546	phosphoglycolate phosphatase activity
Vp2S01_RS07865	COG1757	Na H antiporter
Vp2S01_RS07870	COG0174	glutamine synthetase
Vp2S01_RS07880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Vp2S01_RS07885	COG1396	sequence-specific DNA binding
Vp2S01_RS07885	COG1917	Cupin 2, conserved barrel domain protein
Vp2S01_RS07890	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_RS07895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vp2S01_RS07905	COG2957	Belongs to the agmatine deiminase family
Vp2S01_RS07910	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_RS07915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vp2S01_RS07920	COG1227	inorganic diphosphatase activity
Vp2S01_RS07930	COG2200	EAL domain
Vp2S01_RS07930	COG2771	luxR family
Vp2S01_RS07945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vp2S01_RS07960	COG1846	Transcriptional regulator
Vp2S01_RS07965	COG2315	Protein conserved in bacteria
Vp2S01_RS07985	COG0110	maltose O-acetyltransferase activity
Vp2S01_RS08015	COG3063	Type IV pilus biogenesis stability protein PilW
Vp2S01_RS08020	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Vp2S01_RS08035	COG0531	amino acid
Vp2S01_RS08045	COG1560	Kdo2-lipid A biosynthetic process
Vp2S01_RS08050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Vp2S01_RS08055	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_RS08065	COG1115	amino acid carrier protein
Vp2S01_RS08090	COG1368	sulfuric ester hydrolase activity
Vp2S01_RS08095	COG0642	Histidine kinase
Vp2S01_RS08100	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS08130	COG2113	Glycine betaine
Vp2S01_RS08135	COG4176	ABC-type proline glycine betaine transport system permease component
Vp2S01_RS08155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_RS08160	COG0456	acetyltransferase
Vp2S01_RS08165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vp2S01_RS08170	COG0662	Cupin 2, conserved barrel domain protein
Vp2S01_RS08175	COG0527	aspartate kinase activity
Vp2S01_RS08190	COG1858	cytochrome C peroxidase
Vp2S01_RS08205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_RS08220	COG3290	protein histidine kinase activity
Vp2S01_RS08225	COG4565	transcriptional regulatory protein
Vp2S01_RS08230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Vp2S01_RS08235	COG0363	glucosamine-6-phosphate deaminase activity
Vp2S01_RS08240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Vp2S01_RS08265	COG3284	Transcriptional regulator
Vp2S01_RS08270	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_RS08340	COG4669	(LipO)protein
Vp2S01_RS08360	COG3177	Filamentation induced by cAMP protein fic
Vp2S01_RS08400	COG1073	alpha beta
Vp2S01_RS08405	COG1073	alpha beta
Vp2S01_RS08415	COG4792	protein secretion
Vp2S01_RS08420	COG4791	protein targeting
Vp2S01_RS08425	COG4794	Type iii secretion
Vp2S01_RS08430	COG4790	Type iii secretion
Vp2S01_RS08500	COG0457	Tetratricopeptide repeat
Vp2S01_RS08520	COG0730	response to heat
Vp2S01_RS08550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Vp2S01_RS08555	COG0372	Belongs to the citrate synthase family
Vp2S01_RS08565	COG2828	Protein conserved in bacteria
Vp2S01_RS08590	COG0561	phosphatase activity
Vp2S01_RS08595	COG0602	queuosine metabolic process
Vp2S01_RS08600	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vp2S01_RS08605	COG3706	GGDEF domain
Vp2S01_RS08645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vp2S01_RS08655	COG1254	Belongs to the acylphosphatase family
Vp2S01_RS08660	COG2920	part of a sulfur-relay system
Vp2S01_RS08670	COG0670	Belongs to the BI1 family
Vp2S01_RS08675	COG1126	abc transporter atp-binding protein
Vp2S01_RS08680	COG0765	amino acid transport
Vp2S01_RS08685	COG4597	amino acid ABC transporter
Vp2S01_RS08690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_RS08710	COG1666	GTP binding
Vp2S01_RS08715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vp2S01_RS08735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vp2S01_RS08735	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Vp2S01_RS08745	COG3008	intermembrane lipid transfer
Vp2S01_RS08750	COG2995	paraquat-inducible protein a
Vp2S01_RS08755	COG1132	(ABC) transporter
Vp2S01_RS08760	COG1956	GAF domain-containing protein
Vp2S01_RS08765	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Vp2S01_RS08780	COG0308	aminopeptidase N
Vp2S01_RS08790	COG2902	Dehydrogenase
Vp2S01_RS08795	COG0167	dihydroorotate dehydrogenase activity
Vp2S01_RS08810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vp2S01_RS08810	COG0116	Belongs to the methyltransferase superfamily
Vp2S01_RS08820	COG0488	(ABC) transporter
Vp2S01_RS08835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vp2S01_RS08840	COG1067	ATP-dependent peptidase activity
Vp2S01_RS08845	COG3120	sequence-specific DNA binding
Vp2S01_RS08885	COG2205	protein histidine kinase activity
Vp2S01_RS08885	COG0784	Response regulator, receiver
Vp2S01_RS08900	COG3278	Belongs to the heme-copper respiratory oxidase family
Vp2S01_RS08915	COG2010	Cytochrome c
Vp2S01_RS08925	COG2217	Heavy metal translocating P-type atpase
Vp2S01_RS08940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vp2S01_RS08945	COG0589	response to stress
Vp2S01_RS08955	COG0037	tRNA processing
Vp2S01_RS08975	COG3842	ATPase activity
Vp2S01_RS08985	COG1177	transmembrane transport
Vp2S01_RS08995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Vp2S01_RS09000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Vp2S01_RS09010	COG0004	ammonium transporteR
Vp2S01_RS09035	COG0437	4 iron, 4 sulfur cluster binding
Vp2S01_RS09040	COG0243	molybdopterin cofactor binding
Vp2S01_RS09040	COG3383	formate dehydrogenase (NAD+) activity
Vp2S01_RS09050	COG3381	protein complex oligomerization
Vp2S01_RS09075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Vp2S01_RS09080	COG0488	(ABC) transporter
Vp2S01_RS09090	COG4191	Histidine kinase
Vp2S01_RS09095	COG2204	response regulator
Vp2S01_RS09115	COG3842	ATPase activity
Vp2S01_RS09120	COG0746	molybdenum cofactor guanylyltransferase activity
Vp2S01_RS09125	COG0303	'Molybdopterin
Vp2S01_RS09135	COG1940	carbohydrate kinase activity
Vp2S01_RS09140	COG3148	PFAM DTW domain containing protein
Vp2S01_RS09175	COG0840	transmembrane signaling receptor activity
Vp2S01_RS09180	COG0791	NLP P60 protein
Vp2S01_RS09190	COG3706	GGDEF domain
Vp2S01_RS09195	COG2201	protein-glutamate methylesterase activity
Vp2S01_RS09200	COG3001	Fructosamine kinase
Vp2S01_RS09210	COG0307	riboflavin synthase, alpha
Vp2S01_RS09215	COG0534	Mate efflux family protein
Vp2S01_RS09225	COG1793	dna ligase
Vp2S01_RS09260	COG2204	response regulator
Vp2S01_RS09270	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_RS09305	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_RS09310	COG1215	transferase activity, transferring glycosyl groups
Vp2S01_RS09315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vp2S01_RS09325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_RS09340	COG1643	Atp-dependent helicase
Vp2S01_RS09345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Vp2S01_RS09360	COG3302	dmso reductase anchor subunit
Vp2S01_RS09365	COG0437	4 iron, 4 sulfur cluster binding
Vp2S01_RS09370	COG0243	molybdopterin cofactor binding
Vp2S01_RS09410	COG0443	Heat shock 70 kDa protein
Vp2S01_RS09415	COG0443	Heat shock 70 kDa protein
Vp2S01_RS09445	COG1132	(ABC) transporter
Vp2S01_RS09450	COG1132	(ABC) transporter
Vp2S01_RS09475	COG0814	amino acid
Vp2S01_RS09490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Vp2S01_RS09570	COG1522	sequence-specific DNA binding
Vp2S01_RS09605	COG0515	serine threonine protein kinase
Vp2S01_RS09630	COG3501	Rhs element vgr protein
Vp2S01_RS09670	COG0739	heme binding
Vp2S01_RS09680	COG0861	Integral membrane protein TerC family
Vp2S01_RS09690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vp2S01_RS09695	COG1328	CTP reductase activity
Vp2S01_RS09700	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_RS09710	COG5001	Diguanylate cyclase
Vp2S01_RS09710	COG3300	MHYT domain
Vp2S01_RS09720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_RS09720	COG4191	Histidine kinase
Vp2S01_RS09725	COG0471	metal ion transport
Vp2S01_RS09760	COG0583	DNA-binding transcription factor activity
Vp2S01_RS09765	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Vp2S01_RS09840	COG0758	DNA mediated transformation
Vp2S01_RS09975	COG1783	phage Terminase large subunit
Vp2S01_RS10140	COG0625	glutathione transferase activity
Vp2S01_RS10150	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Vp2S01_RS10165	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vp2S01_RS10175	COG0601	transmembrane transport
Vp2S01_RS10180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vp2S01_RS10185	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_RS10205	COG3291	Pkd domain containing protein
Vp2S01_RS10220	COG1177	transmembrane transport
Vp2S01_RS10225	COG1176	ABC-type spermidine putrescine transport system, permease component I
Vp2S01_RS10230	COG3842	ATPase activity
Vp2S01_RS10235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vp2S01_RS10240	COG2423	ornithine cyclodeaminase activity
Vp2S01_RS10260	COG3938	Belongs to the proline racemase family
Vp2S01_RS10290	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
Vp2S01_RS10295	COG1451	nucleotide metabolic process
Vp2S01_RS10305	COG0583	DNA-binding transcription factor activity
Vp2S01_RS10325	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Vp2S01_RS10330	COG4139	cobalamin transport
Vp2S01_RS10335	COG2988	succinylglutamate desuccinylase activity
Vp2S01_RS10350	COG2062	phosphohistidine phosphatase, SixA
Vp2S01_RS10360	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Vp2S01_RS10365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vp2S01_RS10370	COG0702	epimerase
Vp2S01_RS10375	COG1823	symporter activity
Vp2S01_RS10380	COG2925	Exonuclease
Vp2S01_RS10385	COG1380	Effector of murein hydrolase LrgA
Vp2S01_RS10390	COG1346	cytolysis
Vp2S01_RS10395	COG0295	cytidine deaminase activity
Vp2S01_RS10400	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Vp2S01_RS10405	COG0500	methyltransferase
Vp2S01_RS10415	COG0776	regulation of translation
Vp2S01_RS10430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vp2S01_RS10430	COG0072	phenylalanine-tRNA ligase activity
Vp2S01_RS10435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Vp2S01_RS10440	COG3706	GGDEF domain
Vp2S01_RS10470	COG0393	Putative heavy-metal-binding
Vp2S01_RS10480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Vp2S01_RS10490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vp2S01_RS10505	COG2188	Transcriptional regulator
Vp2S01_RS10510	COG1228	amidohydrolase
Vp2S01_RS10515	COG0010	Belongs to the arginase family
Vp2S01_RS10520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Vp2S01_RS10525	COG2986	histidine ammonia-lyase
Vp2S01_RS10540	COG0247	lactate metabolic process
Vp2S01_RS10540	COG0277	FAD linked oxidase domain protein
Vp2S01_RS10575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Vp2S01_RS10590	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Vp2S01_RS10595	COG1643	Atp-dependent helicase
Vp2S01_RS10600	COG0281	malic enzyme
Vp2S01_RS10605	COG2949	membrane
Vp2S01_RS10610	COG0471	metal ion transport
Vp2S01_RS10635	COG0492	ferredoxin-NADP+ reductase activity
Vp2S01_RS10640	COG4988	ABC transporter
Vp2S01_RS10645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Vp2S01_RS10650	COG3048	D-serine ammonia-lyase activity
Vp2S01_RS10655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Vp2S01_RS10665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_RS10665	COG4191	Histidine kinase
Vp2S01_RS10680	COG3070	regulator of competence-specific genes
Vp2S01_RS10700	COG2431	L-lysine efflux transmembrane transporter activity
Vp2S01_RS10710	COG0076	glutamate decarboxylase activity
Vp2S01_RS10715	COG1737	Transcriptional regulator
Vp2S01_RS10730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Vp2S01_RS10735	COG2985	domain, Protein
Vp2S01_RS10735	COG3273	potassium ion transport
Vp2S01_RS10740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Vp2S01_RS10755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vp2S01_RS10770	COG4181	ATPase activity
Vp2S01_RS10775	COG0534	Mate efflux family protein
Vp2S01_RS10780	COG0702	epimerase
Vp2S01_RS10785	COG3005	denitrification pathway
Vp2S01_RS10815	COG2814	Major facilitator Superfamily
Vp2S01_RS10820	COG1187	pseudouridine synthase activity
Vp2S01_RS10825	COG1061	Type III restriction enzyme res subunit
Vp2S01_RS10845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Vp2S01_RS10875	COG3313	Fe-S protein
Vp2S01_RS10900	COG0493	'glutamate synthase
Vp2S01_RS10910	COG0398	Pfam SNARE associated Golgi protein
Vp2S01_RS10915	COG4134	Bacterial extracellular solute-binding protein
Vp2S01_RS10920	COG4135	transport system, permease component
Vp2S01_RS10925	COG4136	ATPase activity
Vp2S01_RS10930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Vp2S01_RS10945	COG3604	Transcriptional regulator
Vp2S01_RS10950	COG1151	hydroxylamine reductase activity
Vp2S01_RS10955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vp2S01_RS10965	COG0564	pseudouridine synthase activity
Vp2S01_RS10975	COG0733	neurotransmitter:sodium symporter activity
Vp2S01_RS10985	COG0626	cystathionine gamma-synthase activity
Vp2S01_RS10990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Vp2S01_RS10995	COG5380	lipid catabolic process
Vp2S01_RS11000	COG2818	Glycosylase
Vp2S01_RS11015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_RS11020	COG1983	PspC domain protein
Vp2S01_RS11030	COG1842	Phage shock protein A
Vp2S01_RS11035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Vp2S01_RS11050	COG4171	peptide transport system, permease
Vp2S01_RS11060	COG4172	Belongs to the ABC transporter superfamily
Vp2S01_RS11070	COG1227	inorganic diphosphatase activity
Vp2S01_RS11085	COG0243	molybdopterin cofactor binding
Vp2S01_RS11090	COG3005	denitrification pathway
Vp2S01_RS11095	COG4459	periplasmic nitrate reductase
Vp2S01_RS11100	COG0390	transport system, permease component
Vp2S01_RS11110	COG2116	formate transmembrane transporter activity
Vp2S01_RS11135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Vp2S01_RS11140	COG1435	thymidine kinase activity
Vp2S01_RS11145	COG0215	cysteine-tRNA ligase activity
Vp2S01_RS11150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Vp2S01_RS11155	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vp2S01_RS11160	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Vp2S01_RS11170	COG3012	SEC-C Motif Domain Protein
Vp2S01_RS11175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vp2S01_RS11175	COG0140	phosphoribosyl-ATP diphosphatase activity
Vp2S01_RS11180	COG0107	imidazoleglycerol-phosphate synthase activity
Vp2S01_RS11185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Vp2S01_RS11190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Vp2S01_RS11195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Vp2S01_RS11195	COG0131	Imidazoleglycerol-phosphate dehydratase
Vp2S01_RS11200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vp2S01_RS11205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Vp2S01_RS11210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Vp2S01_RS11225	COG1757	Na H antiporter
Vp2S01_RS11235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_RS11245	COG0482	sulfurtransferase activity
Vp2S01_RS11250	COG2915	High frequency lysogenization protein hflD homolog
Vp2S01_RS11255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Vp2S01_RS11280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Vp2S01_RS11295	COG0300	oxidoreductase activity
Vp2S01_RS11305	COG0501	Belongs to the peptidase M48B family
Vp2S01_RS11315	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Vp2S01_RS11325	COG0156	8-amino-7-oxononanoate synthase activity
Vp2S01_RS11330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Vp2S01_RS11335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vp2S01_RS11340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Vp2S01_RS11355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Vp2S01_RS11360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Vp2S01_RS11365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Vp2S01_RS11370	COG1674	ftsk spoiiie
Vp2S01_RS11380	COG0686	Belongs to the AlaDH PNT family
Vp2S01_RS11390	COG0583	DNA-binding transcription factor activity
Vp2S01_RS11405	COG3568	Endonuclease Exonuclease Phosphatase
Vp2S01_RS11435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_RS11440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_RS11455	COG0840	transmembrane signaling receptor activity
Vp2S01_RS11525	COG0784	Response regulator, receiver
Vp2S01_RS11525	COG5002	protein histidine kinase activity
Vp2S01_RS11535	COG0754	glutathionylspermidine amidase activity
Vp2S01_RS11545	COG3766	membrane
Vp2S01_RS11555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Vp2S01_RS11560	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Vp2S01_RS11565	COG2885	chlorophyll binding
Vp2S01_RS11570	COG0823	Involved in the tonB-independent uptake of proteins
Vp2S01_RS11585	COG0811	peptide transport
Vp2S01_RS11590	COG0824	Thioesterase
Vp2S01_RS11600	COG4890	Cyd operon protein YbgT
Vp2S01_RS11605	COG1294	oxidase, subunit
Vp2S01_RS11610	COG1271	oxidase subunit
Vp2S01_RS11615	COG2255	four-way junction helicase activity
Vp2S01_RS11620	COG0632	four-way junction helicase activity
Vp2S01_RS11625	COG0840	transmembrane signaling receptor activity
Vp2S01_RS11630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Vp2S01_RS11635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Vp2S01_RS11640	COG1801	Protein of unknown function DUF72
Vp2S01_RS11645	COG4106	trans-aconitate 2-methyltransferase activity
Vp2S01_RS11650	COG0500	methyltransferase
Vp2S01_RS11660	COG0189	ligase activity
Vp2S01_RS11660	COG4067	protein conserved in archaea
Vp2S01_RS11680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Vp2S01_RS11685	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
Vp2S01_RS11690	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
Vp2S01_RS11695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vp2S01_RS11700	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Vp2S01_RS11705	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS11710	COG3381	protein complex oligomerization
Vp2S01_RS11715	COG1609	Transcriptional regulator
Vp2S01_RS11720	COG3070	regulator of competence-specific genes
Vp2S01_RS11740	COG0297	glycogen (starch) synthase activity
Vp2S01_RS11745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Vp2S01_RS11750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vp2S01_RS11760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Vp2S01_RS11770	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Vp2S01_RS11775	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Vp2S01_RS11780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Vp2S01_RS11790	COG0542	response to heat
Vp2S01_RS11795	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Vp2S01_RS11800	COG1278	Cold shock
Vp2S01_RS11810	COG1187	pseudouridine synthase activity
Vp2S01_RS11815	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Vp2S01_RS11825	COG1199	ATP-dependent helicase activity
Vp2S01_RS11830	COG0730	response to heat
Vp2S01_RS11835	COG3923	Primosomal replication protein n
Vp2S01_RS11845	COG0708	Exodeoxyribonuclease III
Vp2S01_RS11890	COG1882	Formate acetyltransferase
Vp2S01_RS11900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vp2S01_RS11910	COG3013	Belongs to the UPF0304 family
Vp2S01_RS11920	COG2766	serine protein kinase
Vp2S01_RS11925	COG2718	Belongs to the UPF0229 family
Vp2S01_RS11930	COG2719	SpoVR family
Vp2S01_RS11935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Vp2S01_RS11945	COG1663	tetraacyldisaccharide 4'-kinase activity
Vp2S01_RS11950	COG1132	(ABC) transporter
Vp2S01_RS11955	COG0658	competence protein
Vp2S01_RS11955	COG2333	competence protein COMEC
Vp2S01_RS11965	COG4591	ABC-type transport system involved in lipoprotein release permease component
Vp2S01_RS11970	COG1136	(ABC) transporter
Vp2S01_RS11975	COG4591	ABC-type transport system involved in lipoprotein release permease component
Vp2S01_RS11985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Vp2S01_RS12000	COG1252	NADH dehydrogenase
Vp2S01_RS12010	COG3150	esterase
Vp2S01_RS12035	COG0537	adenosine 5'-monophosphoramidase activity
Vp2S01_RS12065	COG0516	GMP reductase activity
Vp2S01_RS12065	COG0517	IMP dehydrogenase activity
Vp2S01_RS12075	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Vp2S01_RS12080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Vp2S01_RS12085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vp2S01_RS12160	COG2199	diguanylate cyclase activity
Vp2S01_RS12175	COG3126	Type III secretion system lipoprotein chaperone (YscW)
Vp2S01_RS12180	COG1946	Acyl-CoA thioesterase
Vp2S01_RS12190	COG1522	sequence-specific DNA binding
Vp2S01_RS12220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_RS12270	COG0477	Major facilitator Superfamily
Vp2S01_RS12275	COG2855	membrane
Vp2S01_RS12295	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Vp2S01_RS12300	COG0596	Alpha beta hydrolase
Vp2S01_RS12305	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Vp2S01_RS12310	COG1169	isochorismate synthase
Vp2S01_RS12315	COG0436	Aminotransferase
Vp2S01_RS12320	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Vp2S01_RS12325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Vp2S01_RS12340	COG1555	photosystem II stabilization
Vp2S01_RS12345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vp2S01_RS12350	COG0776	regulation of translation
Vp2S01_RS12355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Vp2S01_RS12360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Vp2S01_RS12370	COG0544	peptidyl-prolyl cis-trans isomerase activity
Vp2S01_RS12380	COG2204	response regulator
Vp2S01_RS12390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vp2S01_RS12395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vp2S01_RS12400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vp2S01_RS12405	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Vp2S01_RS12425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vp2S01_RS12430	COG0569	domain protein
Vp2S01_RS12435	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS12440	COG1253	flavin adenine dinucleotide binding
Vp2S01_RS12475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vp2S01_RS12480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vp2S01_RS12495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vp2S01_RS12500	COG1216	Glycosyl transferase, family 2
Vp2S01_RS12505	COG2986	histidine ammonia-lyase
Vp2S01_RS12530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vp2S01_RS12540	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS12560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Vp2S01_RS12565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Vp2S01_RS12570	COG0583	DNA-binding transcription factor activity
Vp2S01_RS12575	COG2951	lytic endotransglycosylase activity
Vp2S01_RS12580	COG3100	YcgL domain-containing protein
Vp2S01_RS12585	COG0850	regulation of cytokinetic process
Vp2S01_RS12590	COG2894	cell division
Vp2S01_RS12595	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Vp2S01_RS12600	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Vp2S01_RS12605	COG0318	PFAM AMP-dependent synthetase and ligase
Vp2S01_RS12610	COG2267	carboxylic ester hydrolase activity
Vp2S01_RS12625	COG1214	PFAM Peptidase M22, glycoprotease
Vp2S01_RS12630	COG1199	ATP-dependent helicase activity
Vp2S01_RS12635	COG0788	formyltetrahydrofolate deformylase activity
Vp2S01_RS12640	COG3102	Protein conserved in bacteria
Vp2S01_RS12650	COG0018	arginyl-trna synthetase
Vp2S01_RS12670	COG1918	ferrous iron import across plasma membrane
Vp2S01_RS12685	COG4977	sequence-specific DNA binding
Vp2S01_RS12690	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Vp2S01_RS12695	COG1121	(ABC) transporter
Vp2S01_RS12700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Vp2S01_RS12710	COG0045	succinate-CoA ligase (ADP-forming) activity
Vp2S01_RS12715	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vp2S01_RS12720	COG0567	Dehydrogenase, E1 component
Vp2S01_RS12725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Vp2S01_RS12730	COG1053	succinate dehydrogenase
Vp2S01_RS12735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Vp2S01_RS12750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Vp2S01_RS12760	COG0033	Phosphoglucomutase
Vp2S01_RS12765	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Vp2S01_RS12770	COG0596	Alpha beta hydrolase
Vp2S01_RS12780	COG0716	FMN binding
Vp2S01_RS12790	COG0735	belongs to the Fur family
Vp2S01_RS12795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vp2S01_RS12800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_RS12800	COG1263	PTS System
Vp2S01_RS12810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Vp2S01_RS12815	COG1940	carbohydrate kinase activity
Vp2S01_RS12815	COG1846	Transcriptional regulator
Vp2S01_RS12820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Vp2S01_RS12820	COG4651	solute:proton antiporter activity
Vp2S01_RS12825	COG0367	asparagine synthase
Vp2S01_RS12830	COG0250	Participates in transcription elongation, termination and antitermination
Vp2S01_RS12835	COG3104	oligopeptide transport
Vp2S01_RS12840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Vp2S01_RS12845	COG0563	adenylate kinase activity
Vp2S01_RS12850	COG0326	Molecular chaperone. Has ATPase activity
Vp2S01_RS12855	COG3710	Transcriptional regulator
Vp2S01_RS12875	COG0622	Phosphoesterase
Vp2S01_RS12905	COG1090	epimerase
Vp2S01_RS12910	COG0300	oxidoreductase activity
Vp2S01_RS12920	COG3118	belongs to the thioredoxin family
Vp2S01_RS12925	COG0330	HflC and HflK could
Vp2S01_RS12955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Vp2S01_RS12960	COG3115	cell septum assembly
Vp2S01_RS12965	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Vp2S01_RS12970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Vp2S01_RS12980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_RS12985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vp2S01_RS12990	COG2190	(PTS) system
Vp2S01_RS13000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS13005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS13015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS13025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS13035	COG3951	Flagellar rod assembly protein muramidase FlgJ
Vp2S01_RS13035	COG1705	Flagellar rod assembly protein muramidase FlgJ
Vp2S01_RS13040	COG1706	bacterial-type flagellum-dependent cell motility
Vp2S01_RS13045	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Vp2S01_RS13055	COG4787	bacterial-type flagellum-dependent cell motility
Vp2S01_RS13065	COG1749	Flagellar hook protein flgE
Vp2S01_RS13075	COG1558	bacterial-type flagellum-dependent cell motility
Vp2S01_RS13080	COG1815	bacterial-type flagellum-dependent cell motility
Vp2S01_RS13085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Vp2S01_RS13090	COG0835	chemotaxis
Vp2S01_RS13090	COG0784	Response regulator, receiver
Vp2S01_RS13150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vp2S01_RS13155	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Vp2S01_RS13170	COG2217	Heavy metal translocating P-type atpase
Vp2S01_RS13170	COG2608	mercury ion transmembrane transporter activity
Vp2S01_RS13210	COG2840	Smr protein MutS2
Vp2S01_RS13215	COG1187	pseudouridine synthase activity
Vp2S01_RS13225	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_RS13230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Vp2S01_RS13235	COG2912	Transglutaminase-like superfamily
Vp2S01_RS13240	COG3094	Invasion gene expression up-regulator, SirB
Vp2S01_RS13245	COG2890	protein-(glutamine-N5) methyltransferase activity
Vp2S01_RS13250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Vp2S01_RS13255	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Vp2S01_RS13260	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Vp2S01_RS13265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Vp2S01_RS13270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Vp2S01_RS13275	COG0193	aminoacyl-tRNA hydrolase activity
Vp2S01_RS13280	COG0012	GTP binding
Vp2S01_RS13395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vp2S01_RS13405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vp2S01_RS13410	COG1702	phosphate starvation-inducible protein PhoH
Vp2S01_RS13415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Vp2S01_RS13420	COG4535	Mg2 and Co2 transporter CorC
Vp2S01_RS13425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Vp2S01_RS13430	COG2888	peptidyl-tyrosine sulfation
Vp2S01_RS13435	COG0495	leucyl-tRNA aminoacylation
Vp2S01_RS13440	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Vp2S01_RS13445	COG1466	dna polymerase III delta subunit
Vp2S01_RS13450	COG0799	negative regulation of ribosome biogenesis
Vp2S01_RS13455	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Vp2S01_RS13460	COG0768	penicillin binding
Vp2S01_RS13465	COG0772	Belongs to the SEDS family
Vp2S01_RS13470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Vp2S01_RS13475	COG1686	Belongs to the peptidase S11 family
Vp2S01_RS13480	COG2921	Belongs to the UPF0250 family
Vp2S01_RS13485	COG0321	lipoyl(octanoyl) transferase activity
Vp2S01_RS13490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Vp2S01_RS13495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vp2S01_RS13500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Vp2S01_RS13515	COG0366	Alpha amylase catalytic
Vp2S01_RS13520	COG1263	PTS System
Vp2S01_RS13520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_RS13530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Vp2S01_RS13540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Vp2S01_RS13545	COG2011	ABC-type metal ion transport system permease component
Vp2S01_RS13550	COG1464	Belongs to the NlpA lipoprotein family
Vp2S01_RS13555	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
Vp2S01_RS13565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vp2S01_RS13565	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vp2S01_RS13580	COG1611	Belongs to the LOG family
Vp2S01_RS13585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Vp2S01_RS13595	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Vp2S01_RS13600	COG2363	Small membrane protein
Vp2S01_RS13610	COG0583	DNA-binding transcription factor activity
Vp2S01_RS13615	COG0301	tRNA thio-modification
Vp2S01_RS13615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vp2S01_RS13620	COG2885	chlorophyll binding
Vp2S01_RS13625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Vp2S01_RS13630	COG1722	exodeoxyribonuclease VII activity
Vp2S01_RS13635	COG0142	geranyltranstransferase activity
Vp2S01_RS13640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Vp2S01_RS13645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Vp2S01_RS13650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Vp2S01_RS13655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vp2S01_RS13675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vp2S01_RS13675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vp2S01_RS13680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Vp2S01_RS13685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Vp2S01_RS13690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Vp2S01_RS13700	COG1073	alpha beta
Vp2S01_RS13705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vp2S01_RS13710	COG2252	PERMEase
Vp2S01_RS13715	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vp2S01_RS13740	COG0047	phosphoribosylformylglycinamidine synthase activity
Vp2S01_RS13740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Vp2S01_RS13745	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Vp2S01_RS13760	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Vp2S01_RS13800	COG0484	heat shock protein binding
Vp2S01_RS13805	COG0443	Heat shock 70 kDa protein
Vp2S01_RS13815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Vp2S01_RS13820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vp2S01_RS13830	COG0497	DNA recombination
Vp2S01_RS13835	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vp2S01_RS13840	COG2914	Belongs to the UPF0125 (RnfH) family
Vp2S01_RS13845	COG2867	negative regulation of translational initiation
Vp2S01_RS13850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Vp2S01_RS13860	COG0582	viral genome integration into host DNA
Vp2S01_RS13865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Vp2S01_RS13875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Vp2S01_RS13890	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Vp2S01_RS13915	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_RS13920	COG2003	Belongs to the UPF0758 family
Vp2S01_RS13965	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_RS14005	COG0583	DNA-binding transcription factor activity
Vp2S01_RS14010	COG3153	acetyltransferase
Vp2S01_RS14010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vp2S01_RS14030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vp2S01_RS14035	COG2873	o-acetylhomoserine
Vp2S01_RS14070	COG1115	amino acid carrier protein
Vp2S01_RS14080	COG1584	GPR1 FUN34 yaaH family protein
Vp2S01_RS14095	COG0519	Catalyzes the synthesis of GMP from XMP
Vp2S01_RS14095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Vp2S01_RS14100	COG0516	GMP reductase activity
Vp2S01_RS14100	COG0517	IMP dehydrogenase activity
Vp2S01_RS14105	COG1570	exodeoxyribonuclease VII activity
Vp2S01_RS14120	COG1160	GTP binding
Vp2S01_RS14125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vp2S01_RS14130	COG2976	Protein conserved in bacteria
Vp2S01_RS14135	COG0124	histidyl-tRNA synthetase
Vp2S01_RS14140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Vp2S01_RS14155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Vp2S01_RS14160	COG0105	UTP biosynthetic process
Vp2S01_RS14165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Vp2S01_RS14170	COG2975	iron-sulfur cluster assembly
Vp2S01_RS14175	COG0633	Ferredoxin
Vp2S01_RS14180	COG0443	Heat shock 70 kDa protein
Vp2S01_RS14185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Vp2S01_RS14195	COG0822	iron-sulfur transferase activity
Vp2S01_RS14200	COG1104	cysteine desulfurase activity
Vp2S01_RS14215	COG0483	inositol monophosphate 1-phosphatase activity
Vp2S01_RS14225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vp2S01_RS14230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vp2S01_RS14235	COG1862	Preprotein translocase
Vp2S01_RS14240	COG0343	queuine tRNA-ribosyltransferase activity
Vp2S01_RS14245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Vp2S01_RS14260	COG0517	IMP dehydrogenase activity
Vp2S01_RS14270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Vp2S01_RS14280	COG0583	DNA-binding transcription factor activity
Vp2S01_RS14285	COG0450	alkyl hydroperoxide reductase
Vp2S01_RS14295	COG3142	Participates in the control of copper homeostasis
Vp2S01_RS14305	COG0704	Plays a role in the regulation of phosphate uptake
Vp2S01_RS14310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Vp2S01_RS14315	COG0581	inorganic phosphate transmembrane transporter activity
Vp2S01_RS14325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Vp2S01_RS14330	COG0248	Ppx GppA phosphatase
Vp2S01_RS14340	COG5002	protein histidine kinase activity
Vp2S01_RS14345	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS14355	COG2974	May be involved in recombination
Vp2S01_RS14360	COG0826	peptidase U32
Vp2S01_RS14365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vp2S01_RS14430	COG0542	response to heat
Vp2S01_RS14440	COG0564	pseudouridine synthase activity
Vp2S01_RS14445	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vp2S01_RS14450	COG0741	lytic transglycosylase activity
Vp2S01_RS14455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Vp2S01_RS14460	COG1605	Chorismate mutase
Vp2S01_RS14460	COG0077	Prephenate dehydratase
Vp2S01_RS14465	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Vp2S01_RS14470	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
Vp2S01_RS14480	COG0488	(ABC) transporter
Vp2S01_RS14495	COG0739	heme binding
Vp2S01_RS14500	COG1605	Chorismate mutase
Vp2S01_RS14500	COG0287	Prephenate dehydrogenase
Vp2S01_RS14505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vp2S01_RS14510	COG1472	Belongs to the glycosyl hydrolase 3 family
Vp2S01_RS14515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Vp2S01_RS14520	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Vp2S01_RS14535	COG1966	Carbon starvation protein
Vp2S01_RS14540	COG3275	phosphorelay sensor kinase activity
Vp2S01_RS14545	COG3279	Response regulator of the LytR AlgR family
Vp2S01_RS14550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Vp2S01_RS14555	COG1047	Peptidyl-prolyl cis-trans
Vp2S01_RS14560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Vp2S01_RS14565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vp2S01_RS14570	COG0196	riboflavin kinase activity
Vp2S01_RS14575	COG0728	peptidoglycan biosynthetic process
Vp2S01_RS14580	COG0268	Binds directly to 16S ribosomal RNA
Vp2S01_RS14590	COG0640	Transcriptional regulator
Vp2S01_RS14600	COG0583	DNA-binding transcription factor activity
Vp2S01_RS14605	COG1283	sodium-dependent phosphate transmembrane transporter activity
Vp2S01_RS14615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Vp2S01_RS14620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Vp2S01_RS14625	COG0730	response to heat
Vp2S01_RS14635	COG0494	nUDIX hydrolase
Vp2S01_RS14645	COG3066	DNA modification
Vp2S01_RS14655	COG0667	Aldo Keto reductase
Vp2S01_RS14670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Vp2S01_RS14680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Vp2S01_RS14685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vp2S01_RS14690	COG4974	Belongs to the 'phage' integrase family
Vp2S01_RS14695	COG0716	FMN binding
Vp2S01_RS14705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Vp2S01_RS14710	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS14715	COG3022	response to hydroperoxide
Vp2S01_RS14720	COG1115	amino acid carrier protein
Vp2S01_RS14735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Vp2S01_RS14745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Vp2S01_RS14750	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
Vp2S01_RS14755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vp2S01_RS14760	COG0083	homoserine kinase activity
Vp2S01_RS14775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vp2S01_RS14790	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS14800	COG5002	protein histidine kinase activity
Vp2S01_RS14800	COG2198	Histidine kinase
Vp2S01_RS14800	COG0784	Response regulator, receiver
Vp2S01_RS14805	COG3706	GGDEF domain
Vp2S01_RS14805	COG2203	Gaf domain
Vp2S01_RS14805	COG4251	negative regulation of phosphorylation
Vp2S01_RS14805	COG5001	Diguanylate cyclase
Vp2S01_RS14810	COG1242	4 iron, 4 sulfur cluster binding
Vp2S01_RS14815	COG0069	glutamate synthase activity
Vp2S01_RS14815	COG0067	glutamate synthase
Vp2S01_RS14815	COG0070	glutamate synthase
Vp2S01_RS14825	COG0067	glutamate synthase
Vp2S01_RS14825	COG0069	glutamate synthase activity
Vp2S01_RS14825	COG0070	glutamate synthase
Vp2S01_RS14830	COG0493	'glutamate synthase
Vp2S01_RS14840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Vp2S01_RS14850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Vp2S01_RS14855	COG2860	membrane
Vp2S01_RS14860	COG0583	DNA-binding transcription factor activity
Vp2S01_RS14865	COG0730	response to heat
Vp2S01_RS14880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Vp2S01_RS14885	COG0505	Belongs to the CarA family
Vp2S01_RS14890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Vp2S01_RS14895	COG0494	nUDIX hydrolase
Vp2S01_RS14900	COG0653	protein targeting
Vp2S01_RS14910	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Vp2S01_RS14915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Vp2S01_RS14920	COG0849	cell division
Vp2S01_RS14925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Vp2S01_RS14930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vp2S01_RS14935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Vp2S01_RS14940	COG0772	Belongs to the SEDS family
Vp2S01_RS14945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Vp2S01_RS14950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Vp2S01_RS14955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Vp2S01_RS14960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Vp2S01_RS14965	COG0768	penicillin binding
Vp2S01_RS14970	COG3116	cell division
Vp2S01_RS14975	COG0275	rRNA processing
Vp2S01_RS14990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Vp2S01_RS15000	COG0792	nuclease activity
Vp2S01_RS15005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Vp2S01_RS15010	COG2823	Periplasmic or secreted lipoprotein
Vp2S01_RS15015	COG2969	positive regulation of protein catabolic process
Vp2S01_RS15020	COG0625	glutathione transferase activity
Vp2S01_RS15025	COG2857	Cytochrome c1
Vp2S01_RS15030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Vp2S01_RS15035	COG0723	plastoquinol--plastocyanin reductase activity
Vp2S01_RS15040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Vp2S01_RS15045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Vp2S01_RS15055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Vp2S01_RS15065	COG3105	Protein conserved in bacteria
Vp2S01_RS15075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vp2S01_RS15080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Vp2S01_RS15090	COG3150	esterase
Vp2S01_RS15100	COG3151	Protein conserved in bacteria
Vp2S01_RS15105	COG0494	nUDIX hydrolase
Vp2S01_RS15110	COG1538	Outer membrane efflux protein
Vp2S01_RS15115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Vp2S01_RS15115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Vp2S01_RS15120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Vp2S01_RS15135	COG3025	triphosphatase activity
Vp2S01_RS15140	COG1392	Phosphate transport regulator
Vp2S01_RS15145	COG0306	phosphate transporter
Vp2S01_RS15150	COG4991	sh3 domain protein
Vp2S01_RS15160	COG3409	Peptidoglycan-binding domain 1 protein
Vp2S01_RS15160	COG3267	Type II secretory pathway component ExeA
Vp2S01_RS15165	COG0617	tRNA 3'-terminal CCA addition
Vp2S01_RS15170	COG1968	undecaprenyl-diphosphatase activity
Vp2S01_RS15175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Vp2S01_RS15180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Vp2S01_RS15185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Vp2S01_RS15190	COG0596	Alpha beta hydrolase
Vp2S01_RS15195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Vp2S01_RS15200	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Vp2S01_RS15205	COG1610	YqeY-like protein
Vp2S01_RS15210	COG0358	DNA primase activity
Vp2S01_RS15225	COG1464	Belongs to the NlpA lipoprotein family
Vp2S01_RS15260	COG2213	PTS system mannitol-specific
Vp2S01_RS15260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_RS15265	COG0246	Mannitol dehydrogenase
Vp2S01_RS15270	COG3722	fumarate hydratase activity
Vp2S01_RS15275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vp2S01_RS15280	COG5002	protein histidine kinase activity
Vp2S01_RS15295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Vp2S01_RS15300	COG1349	DNA-binding transcription factor activity
Vp2S01_RS15310	COG0469	pyruvate kinase activity
Vp2S01_RS15325	COG0440	acetolactate synthase activity
Vp2S01_RS15330	COG0028	Belongs to the TPP enzyme family
Vp2S01_RS15335	COG1022	Amp-dependent synthetase and ligase
Vp2S01_RS15340	COG0583	DNA-binding transcription factor activity
Vp2S01_RS15360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vp2S01_RS15365	COG0473	3-isopropylmalate dehydrogenase activity
Vp2S01_RS15370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Vp2S01_RS15375	COG0066	3-isopropylmalate dehydratase activity
Vp2S01_RS15385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Vp2S01_RS15390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Vp2S01_RS15395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vp2S01_RS15400	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Vp2S01_RS15405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Vp2S01_RS15410	COG2967	ApaG domain
Vp2S01_RS15415	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Vp2S01_RS15430	COG2966	Psort location CytoplasmicMembrane, score
Vp2S01_RS15435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vp2S01_RS15445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Vp2S01_RS15450	COG0142	geranyltranstransferase activity
Vp2S01_RS15460	COG0039	L-malate dehydrogenase activity
Vp2S01_RS15475	COG2358	TRAP transporter, solute receptor (TAXI family
Vp2S01_RS15495	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Vp2S01_RS15500	COG1178	ABC-type Fe3 transport system permease component
Vp2S01_RS15505	COG4143	(ABC) transporter
Vp2S01_RS15510	COG0163	prenyltransferase activity
Vp2S01_RS15515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vp2S01_RS15525	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Vp2S01_RS15530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Vp2S01_RS15540	COG2105	PFAM AIG2 family protein
Vp2S01_RS15545	COG2911	Protein conserved in bacteria
Vp2S01_RS15550	COG0729	surface antigen
Vp2S01_RS15555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vp2S01_RS15565	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Vp2S01_RS15580	COG4181	ATPase activity
Vp2S01_RS15600	COG0529	Catalyzes the synthesis of activated sulfate
Vp2S01_RS15605	COG0471	metal ion transport
Vp2S01_RS15605	COG3273	potassium ion transport
Vp2S01_RS15615	COG2895	sulfate adenylyltransferase (ATP) activity
Vp2S01_RS15620	COG0175	sulfate reduction
Vp2S01_RS15625	COG1648	precorrin-2 dehydrogenase activity
Vp2S01_RS15625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vp2S01_RS15630	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_RS15640	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS15645	COG2153	protein acetylation
Vp2S01_RS15655	COG0545	Peptidyl-prolyl cis-trans isomerase
Vp2S01_RS15665	COG0203	ribosomal protein L17
Vp2S01_RS15670	COG0202	RNA polymerase activity
Vp2S01_RS15680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Vp2S01_RS15685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Vp2S01_RS15690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Vp2S01_RS15695	COG0201	protein transport
Vp2S01_RS15700	COG0200	Binds to the 23S rRNA
Vp2S01_RS15705	COG1841	ribosomal large subunit assembly
Vp2S01_RS15720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Vp2S01_RS15725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Vp2S01_RS15730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Vp2S01_RS15735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Vp2S01_RS15740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Vp2S01_RS15745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Vp2S01_RS15750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Vp2S01_RS15755	COG0255	Belongs to the universal ribosomal protein uL29 family
Vp2S01_RS15765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Vp2S01_RS15770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Vp2S01_RS15775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Vp2S01_RS15780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vp2S01_RS15790	COG0088	Forms part of the polypeptide exit tunnel
Vp2S01_RS15795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Vp2S01_RS15805	COG0254	rRNA binding
Vp2S01_RS15815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Vp2S01_RS15820	COG1609	Transcriptional regulator
Vp2S01_RS15830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Vp2S01_RS15835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Vp2S01_RS15850	COG2003	Belongs to the UPF0758 family
Vp2S01_RS15880	COG1575	Belongs to the MenA family. Type 1 subfamily
Vp2S01_RS15885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vp2S01_RS15890	COG3074	FtsZ-dependent cytokinesis
Vp2S01_RS15900	COG1494	fructose-1,6-bisphosphatase
Vp2S01_RS15925	COG0149	triose-phosphate isomerase activity
Vp2S01_RS15930	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vp2S01_RS15950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vp2S01_RS15970	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_RS15990	COG1215	transferase activity, transferring glycosyl groups
Vp2S01_RS15995	COG0110	maltose O-acetyltransferase activity
Vp2S01_RS16005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Vp2S01_RS16055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vp2S01_RS16065	COG1560	Kdo2-lipid A biosynthetic process
Vp2S01_RS16070	COG0859	PFAM glycosyl transferase family 9
Vp2S01_RS16075	COG1519	Transferase
Vp2S01_RS16085	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_RS16085	COG0297	glycogen (starch) synthase activity
Vp2S01_RS16105	COG2030	dehydratase
Vp2S01_RS16110	COG0110	maltose O-acetyltransferase activity
Vp2S01_RS16130	COG3642	lipopolysaccharide core region biosynthetic process
Vp2S01_RS16135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Vp2S01_RS16140	COG0859	PFAM glycosyl transferase family 9
Vp2S01_RS16145	COG0463	Glycosyl transferase, family 2
Vp2S01_RS16150	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_RS16165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Vp2S01_RS16180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Vp2S01_RS16185	COG2003	Belongs to the UPF0758 family
Vp2S01_RS16200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Vp2S01_RS16205	COG1309	transcriptional regulator
Vp2S01_RS16210	COG1560	Kdo2-lipid A biosynthetic process
Vp2S01_RS16215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vp2S01_RS16220	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Vp2S01_RS16225	COG1561	YicC-like family, N-terminal region
Vp2S01_RS16265	COG2003	Belongs to the UPF0758 family
Vp2S01_RS16315	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_RS16350	COG4608	Belongs to the ABC transporter superfamily
Vp2S01_RS16355	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_RS16360	COG0747	negative chemotaxis
Vp2S01_RS16365	COG4239	(ABC) transporter, permease
Vp2S01_RS16370	COG4174	ABC transporter (Permease)
Vp2S01_RS16395	COG0811	peptide transport
Vp2S01_RS16400	COG0848	biopolymer transport protein
Vp2S01_RS16415	COG0194	GDP metabolic process
Vp2S01_RS16420	COG1758	RNA polymerase activity
Vp2S01_RS16425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vp2S01_RS16430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vp2S01_RS16435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Vp2S01_RS16445	COG2233	PERMEase
Vp2S01_RS16465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vp2S01_RS16475	COG2183	response to ionizing radiation
Vp2S01_RS16485	COG0596	Alpha beta hydrolase
Vp2S01_RS16490	COG1040	competence protein
Vp2S01_RS16495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Vp2S01_RS16495	COG0316	Belongs to the HesB IscA family
Vp2S01_RS16500	COG0494	nUDIX hydrolase
Vp2S01_RS16505	COG1218	3'(2'),5'-bisphosphate nucleotidase
Vp2S01_RS16515	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Vp2S01_RS16520	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Vp2S01_RS16525	COG3156	type II secretion system protein K
Vp2S01_RS16530	COG4795	General secretion pathway protein
Vp2S01_RS16535	COG2165	general secretion pathway protein
Vp2S01_RS16540	COG2165	general secretion pathway protein
Vp2S01_RS16545	COG2165	general secretion pathway protein
Vp2S01_RS16550	COG1459	type II secretion system
Vp2S01_RS16555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vp2S01_RS16565	COG3031	protein transport across the cell outer membrane
Vp2S01_RS16570	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Vp2S01_RS16575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Vp2S01_RS16580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Vp2S01_RS16590	COG0456	acetyltransferase
Vp2S01_RS16595	COG1490	D-aminoacyl-tRNA deacylase activity
Vp2S01_RS16600	COG1295	ribonuclease BN
Vp2S01_RS16615	COG1217	gtp-binding protein TYPA
Vp2S01_RS16620	COG0174	glutamine synthetase
Vp2S01_RS16630	COG3852	Histidine kinase
Vp2S01_RS16635	COG2204	response regulator
Vp2S01_RS16645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Vp2S01_RS16685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Vp2S01_RS16695	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Vp2S01_RS16695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Vp2S01_RS16720	COG0084	hydrolase, TatD family'
Vp2S01_RS16730	COG0805	protein transport
Vp2S01_RS16735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vp2S01_RS16740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vp2S01_RS16745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Vp2S01_RS16750	COG3165	ubiquinone biosynthetic process from chorismate
Vp2S01_RS16755	COG2226	methyltransferase
Vp2S01_RS16760	COG1322	Protein conserved in bacteria
Vp2S01_RS16775	COG0628	permease
Vp2S01_RS16825	COG2823	Periplasmic or secreted lipoprotein
Vp2S01_RS16835	COG2081	HI0933 family
Vp2S01_RS16845	COG1528	Iron-storage protein
Vp2S01_RS16850	COG0589	response to stress
Vp2S01_RS16865	COG0742	ribosomal rna small subunit methyltransferase
Vp2S01_RS16870	COG5002	protein histidine kinase activity
Vp2S01_RS16870	COG5001	Diguanylate cyclase
Vp2S01_RS16875	COG1522	sequence-specific DNA binding
Vp2S01_RS16880	COG0339	signal peptide processing
Vp2S01_RS16890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Vp2S01_RS16895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vp2S01_RS16900	COG0583	DNA-binding transcription factor activity
Vp2S01_RS16905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Vp2S01_RS16910	COG0800	Aldolase
Vp2S01_RS16915	COG2610	gluconate transmembrane transporter activity
Vp2S01_RS16920	COG3265	gluconokinase activity
Vp2S01_RS16925	COG0129	dihydroxy-acid dehydratase activity
Vp2S01_RS16940	COG0583	DNA-binding transcription factor activity
Vp2S01_RS16945	COG1609	Transcriptional regulator
Vp2S01_RS16985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vp2S01_RS16990	COG0601	transmembrane transport
Vp2S01_RS16995	COG0747	negative chemotaxis
Vp2S01_RS17000	COG4172	Belongs to the ABC transporter superfamily
Vp2S01_RS17065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_RS17070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_RS17080	COG2960	long-chain fatty acid transporting porin activity
Vp2S01_RS17085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vp2S01_RS17090	COG0583	DNA-binding transcription factor activity
Vp2S01_RS17135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Vp2S01_RS17145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vp2S01_RS17150	COG0408	coproporphyrinogen oxidase activity
Vp2S01_RS17155	COG0009	L-threonylcarbamoyladenylate synthase
Vp2S01_RS17160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Vp2S01_RS17165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Vp2S01_RS17170	COG0551	DNA topoisomerase type I activity
Vp2S01_RS17175	COG2922	Belongs to the Smg family
Vp2S01_RS17180	COG0758	DNA mediated transformation
Vp2S01_RS17190	COG0242	peptide deformylase activity
Vp2S01_RS17195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Vp2S01_RS17200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vp2S01_RS17200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vp2S01_RS17205	COG0569	domain protein
Vp2S01_RS17210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vp2S01_RS17220	COG1272	protein, Hemolysin III
Vp2S01_RS17225	COG4326	sporulation control protein
Vp2S01_RS17235	COG3084	Protein conserved in bacteria
Vp2S01_RS17245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Vp2S01_RS17250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vp2S01_RS17255	COG0204	Acyl-transferase
Vp2S01_RS17265	COG0606	chelatase, subunit chli
Vp2S01_RS17275	COG3978	acetolactate synthase activity
Vp2S01_RS17280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Vp2S01_RS17285	COG0129	dihydroxy-acid dehydratase activity
Vp2S01_RS17295	COG0583	DNA-binding transcription factor activity
Vp2S01_RS17300	COG2814	Major facilitator Superfamily
Vp2S01_RS17305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_RS17310	COG0765	amino acid transport
Vp2S01_RS17315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Vp2S01_RS17320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Vp2S01_RS17325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Vp2S01_RS17330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Vp2S01_RS17335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Vp2S01_RS17340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Vp2S01_RS17355	COG0356	it plays a direct role in the translocation of protons across the membrane
Vp2S01_RS17360	COG3312	ion transport
Vp2S01_RS17365	COG1475	DNA binding
Vp2S01_RS17370	COG1192	Involved in chromosome partitioning
Vp2S01_RS17375	COG0357	Ribosomal RNA small subunit methyltransferase G
Vp2S01_RS17380	COG0445	tRNA wobble uridine modification
Vp2S01_RS17400	COG3275	phosphorelay sensor kinase activity
Vp2S01_RS17405	COG3279	Response regulator of the LytR AlgR family
Vp2S01_RS17415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Vp2S01_RS17450	COG0786	glutamate:sodium symporter activity
Vp2S01_RS17460	COG1131	(ABC) transporter
Vp2S01_RS17465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_RS17470	COG0786	glutamate:sodium symporter activity
Vp2S01_RS17485	COG0363	glucosamine-6-phosphate deaminase activity
Vp2S01_RS17505	COG1741	Belongs to the pirin family
Vp2S01_RS17510	COG2259	Doxx family
Vp2S01_RS17525	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Vp2S01_RS17530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Vp2S01_RS17540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Vp2S01_RS17580	COG3123	guanosine phosphorylase activity
Vp2S01_RS17590	COG5001	Diguanylate cyclase
Vp2S01_RS17600	COG0534	Mate efflux family protein
Vp2S01_RS17605	COG0564	pseudouridine synthase activity
Vp2S01_RS17620	COG0583	DNA-binding transcription factor activity
Vp2S01_RS17625	COG0561	phosphatase activity
Vp2S01_RS17635	COG2199	diguanylate cyclase activity
Vp2S01_RS17650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Vp2S01_RS17655	COG2162	N-hydroxyarylamine O-acetyltransferase activity
Vp2S01_RS17660	COG0583	DNA-binding transcription factor activity
Vp2S01_RS17675	COG1414	Transcriptional regulator
Vp2S01_RS17680	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS17690	COG1917	Cupin 2, conserved barrel domain protein
Vp2S01_RS17705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_RS17710	COG0800	Aldolase
Vp2S01_RS17730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vp2S01_RS17735	COG0823	Involved in the tonB-independent uptake of proteins
Vp2S01_RS17740	COG2375	cellular response to nickel ion
Vp2S01_RS17770	COG1357	PFAM Pentapeptide repeats (8 copies)
Vp2S01_RS17775	COG3047	cAMP biosynthetic process
Vp2S01_RS17805	COG3408	Glycogen debranching enzyme
Vp2S01_RS17805	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
Vp2S01_RS17810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Vp2S01_RS17820	COG0583	DNA-binding transcription factor activity
Vp2S01_RS17830	COG0583	DNA-binding transcription factor activity
Vp2S01_RS17835	COG0641	radical SAM
Vp2S01_RS17850	COG0583	DNA-binding transcription factor activity
Vp2S01_RS17890	COG3835	regulator
Vp2S01_RS17895	COG2610	gluconate transmembrane transporter activity
Vp2S01_RS17900	COG1929	Belongs to the glycerate kinase type-1 family
Vp2S01_RS17905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_RS17925	COG0456	acetyltransferase
Vp2S01_RS17940	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS17950	COG3005	denitrification pathway
Vp2S01_RS17955	COG0243	molybdopterin cofactor binding
Vp2S01_RS17965	COG0352	thiamine-phosphate diphosphorylase activity
Vp2S01_RS17970	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Vp2S01_RS17975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Vp2S01_RS17980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vp2S01_RS17985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vp2S01_RS17990	COG1116	anion transmembrane transporter activity
Vp2S01_RS17995	COG0351	phosphomethylpyrimidine kinase
Vp2S01_RS18005	COG0312	modulator of DNA gyrase
Vp2S01_RS18010	COG0312	modulator of DNA gyrase
Vp2S01_RS18015	COG1901	pseudouridine methyltransferase
Vp2S01_RS18080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vp2S01_RS18090	COG0584	glycerophosphoryl diester phosphodiesterase
Vp2S01_RS18095	COG0039	L-malate dehydrogenase activity
Vp2S01_RS18100	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS18120	COG0811	peptide transport
Vp2S01_RS18125	COG0811	peptide transport
Vp2S01_RS18130	COG0848	biopolymer transport protein
Vp2S01_RS18170	COG0803	Belongs to the bacterial solute-binding protein 9 family
Vp2S01_RS18175	COG1121	(ABC) transporter
Vp2S01_RS18180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Vp2S01_RS18195	COG1770	oligopeptidase
Vp2S01_RS18200	COG2814	Major facilitator Superfamily
Vp2S01_RS18205	COG0010	Belongs to the arginase family
Vp2S01_RS18210	COG1166	arginine decarboxylase activity
Vp2S01_RS18220	COG4067	protein conserved in archaea
Vp2S01_RS18220	COG0189	ligase activity
Vp2S01_RS18225	COG0189	ligase activity
Vp2S01_RS18230	COG0583	DNA-binding transcription factor activity
Vp2S01_RS18265	COG4191	Histidine kinase
Vp2S01_RS18275	COG2199	diguanylate cyclase activity
Vp2S01_RS18305	COG0579	oxidoreductase
Vp2S01_RS18315	COG3033	Beta-eliminating lyase
Vp2S01_RS18335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Vp2S01_RS18350	COG3706	GGDEF domain
Vp2S01_RS18355	COG0840	transmembrane signaling receptor activity
Vp2S01_RS18370	COG3706	GGDEF domain
Vp2S01_RS18375	COG0415	Belongs to the DNA photolyase family
Vp2S01_RS18380	COG3046	protein related to deoxyribodipyrimidine photolyase
Vp2S01_RS18395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vp2S01_RS18395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vp2S01_RS18400	COG1765	OsmC-like protein
Vp2S01_RS18405	COG0110	maltose O-acetyltransferase activity
Vp2S01_RS18445	COG1011	Hydrolase
Vp2S01_RS18460	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Vp2S01_RS18470	COG2067	long-chain fatty acid transport protein
Vp2S01_RS18475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_RS18480	COG0577	efflux transmembrane transporter activity
Vp2S01_RS18480	COG1136	(ABC) transporter
Vp2S01_RS18490	COG3240	lipase activity
Vp2S01_RS18520	COG1609	Transcriptional regulator
Vp2S01_RS18525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vp2S01_RS18530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vp2S01_RS18540	COG1840	ABC-type Fe3 transport system, periplasmic component
Vp2S01_RS18550	COG3842	ATPase activity
Vp2S01_RS18575	COG2990	Protein conserved in bacteria
Vp2S01_RS18585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vp2S01_RS18590	COG2866	Carboxypeptidase
Vp2S01_RS18605	COG0583	DNA-binding transcription factor activity
Vp2S01_RS18625	COG3104	oligopeptide transport
Vp2S01_RS18630	COG1760	l-serine dehydratase
Vp2S01_RS18650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vp2S01_RS18655	COG0741	lytic transglycosylase activity
Vp2S01_RS18675	COG1815	bacterial-type flagellum-dependent cell motility
Vp2S01_RS18680	COG1558	bacterial-type flagellum-dependent cell motility
Vp2S01_RS18685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Vp2S01_RS18690	COG1749	Flagellar hook protein flgE
Vp2S01_RS18695	COG4787	bacterial-type flagellum-dependent cell motility
Vp2S01_RS18700	COG4786	Flagellar basal body rod
Vp2S01_RS18705	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Vp2S01_RS18710	COG1706	bacterial-type flagellum-dependent cell motility
Vp2S01_RS18720	COG1256	bacterial-type flagellum assembly
Vp2S01_RS18720	COG4786	Flagellar basal body rod
Vp2S01_RS18725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS18745	COG1304	FMN binding
Vp2S01_RS18770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vp2S01_RS18775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Vp2S01_RS18780	COG0459	protein refolding
Vp2S01_RS18795	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_RS18815	COG1309	transcriptional regulator
Vp2S01_RS18825	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_RS18830	COG2070	2-Nitropropane dioxygenase
Vp2S01_RS18835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_RS18845	COG0583	DNA-binding transcription factor activity
Vp2S01_RS18860	COG0346	lactoylglutathione lyase activity
Vp2S01_RS18865	COG1349	DNA-binding transcription factor activity
Vp2S01_RS18875	COG0753	catalase activity
Vp2S01_RS18885	COG1335	isochorismatase
Vp2S01_RS18895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Vp2S01_RS18925	COG0583	DNA-binding transcription factor activity
Vp2S01_RS18940	COG3713	MltA-interacting MipA family protein
Vp2S01_RS18950	COG3015	lipoprotein NlpE involved in copper resistance
Vp2S01_RS18960	COG1342	Belongs to the UPF0251 family
Vp2S01_RS18995	COG4948	Mandelate Racemase Muconate Lactonizing
Vp2S01_RS19005	COG0583	DNA-binding transcription factor activity
Vp2S01_RS19055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vp2S01_RS19090	COG3842	ATPase activity
Vp2S01_RS19120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_RS19140	COG3706	GGDEF domain
Vp2S01_RS19160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_RS19180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Vp2S01_RS19200	COG0574	Belongs to the PEP-utilizing enzyme family
Vp2S01_RS19200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vp2S01_RS19205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Vp2S01_RS19210	COG0252	asparaginase activity
Vp2S01_RS19215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vp2S01_RS19220	COG0583	DNA-binding transcription factor activity
Vp2S01_RS19240	COG3122	Protein conserved in bacteria
Vp2S01_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS19265	COG1063	alcohol dehydrogenase
Vp2S01_RS19270	COG1902	pentaerythritol trinitrate reductase activity
Vp2S01_RS19285	COG0583	DNA-binding transcription factor activity
Vp2S01_RS19295	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS19340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_RS19345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Vp2S01_RS19345	COG2207	Transcriptional regulator
Vp2S01_RS19375	COG2354	Protein conserved in bacteria
Vp2S01_RS19380	COG0418	dihydroorotase activity
Vp2S01_RS19390	COG0401	homolog of Blt101
Vp2S01_RS19400	COG3217	Mosc domain protein beta barrel domain protein
Vp2S01_RS19400	COG0633	Ferredoxin
Vp2S01_RS19400	COG3217	Mosc domain protein beta barrel domain protein
Vp2S01_RS19400	COG0633	Ferredoxin
Vp2S01_RS19405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vp2S01_RS19410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Vp2S01_RS19455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Vp2S01_RS19460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vp2S01_RS19470	COG0848	biopolymer transport protein
Vp2S01_RS19475	COG0811	peptide transport
Vp2S01_RS19480	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Vp2S01_RS19490	COG3721	Heme iron utilization protein
Vp2S01_RS19495	COG0748	coenzyme F420 binding
Vp2S01_RS19505	COG0835	chemotaxis
Vp2S01_RS19505	COG0784	Response regulator, receiver
Vp2S01_RS19515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vp2S01_RS19520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Vp2S01_RS19550	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_RS19565	COG2814	Major facilitator Superfamily
Vp2S01_RS19585	COG3458	cephalosporin-C deacetylase activity
Vp2S01_RS19595	COG0494	nUDIX hydrolase
Vp2S01_RS19620	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Vp2S01_RS19625	COG0783	Belongs to the Dps family
Vp2S01_RS19635	COG0583	DNA-binding transcription factor activity
Vp2S01_RS19650	COG4934	collagen metabolic process
Vp2S01_RS19660	COG0366	Alpha amylase catalytic
Vp2S01_RS19680	COG2249	NAD(P)H dehydrogenase (quinone) activity
Vp2S01_RS19685	COG0589	response to stress
Vp2S01_RS19690	COG0488	(ABC) transporter
Vp2S01_RS19695	COG1505	serine-type exopeptidase activity
Vp2S01_RS19705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_RS19715	COG2067	long-chain fatty acid transport protein
Vp2S01_RS19725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vp2S01_RS19755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_RS19780	COG3383	formate dehydrogenase (NAD+) activity
Vp2S01_RS19795	COG0842	Transport permease protein
Vp2S01_RS19800	COG1131	(ABC) transporter
Vp2S01_RS19820	COG2706	6-phosphogluconolactonase activity
Vp2S01_RS19830	COG1881	PFAM PEBP family protein
Vp2S01_RS19840	COG0798	PFAM Bile acid sodium symporter
Vp2S01_RS19860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_RS19865	COG2213	PTS system mannitol-specific
Vp2S01_RS19870	COG1063	alcohol dehydrogenase
Vp2S01_RS19880	COG1072	(Pantothenic acid kinase))
Vp2S01_RS19885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Vp2S01_RS19905	COG0814	amino acid
Vp2S01_RS19920	COG3314	Sporulation integral membrane protein YlbJ
Vp2S01_RS19945	COG0739	heme binding
Vp2S01_RS19950	COG5001	Diguanylate cyclase
Vp2S01_RS19955	COG0583	DNA-binding transcription factor activity
Vp2S01_RS19960	COG2814	Major facilitator Superfamily
Vp2S01_RS19985	COG0697	spore germination
Vp2S01_RS20015	COG2207	Transcriptional regulator
Vp2S01_RS20020	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_RS20030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vp2S01_RS20035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Vp2S01_RS20045	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Vp2S01_RS20070	COG1612	heme a metabolic process
Vp2S01_RS20075	COG0109	protoheme IX farnesyltransferase activity
Vp2S01_RS20080	COG0545	Peptidyl-prolyl cis-trans isomerase
Vp2S01_RS20115	COG1278	Cold shock
Vp2S01_RS20120	COG3036	rescue of stalled ribosome
Vp2S01_RS20135	COG2199	diguanylate cyclase activity
Vp2S01_RS20155	COG0577	efflux transmembrane transporter activity
Vp2S01_RS20155	COG1136	(ABC) transporter
Vp2S01_RS20165	COG0840	transmembrane signaling receptor activity
Vp2S01_RS20170	COG0783	Belongs to the Dps family
Vp2S01_RS20180	COG2133	pyrroloquinoline quinone binding
Vp2S01_RS20185	COG1454	alcohol dehydrogenase
Vp2S01_RS20190	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Vp2S01_RS20230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vp2S01_RS20235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vp2S01_RS20240	COG3186	Phenylalanine-4-hydroxylase
Vp2S01_RS20245	COG2154	pterin-4-alpha-carbinolamine dehydratase
Vp2S01_RS20270	COG3530	Putative quorum-sensing-regulated virulence factor
Vp2S01_RS20275	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS20280	COG4628	conserved protein (DUF2132)
Vp2S01_RS20285	COG0133	tryptophan synthase activity
Vp2S01_RS20295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Vp2S01_RS20305	COG0523	cobalamin synthesis protein
Vp2S01_RS20310	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS20330	COG2200	EAL domain
Vp2S01_RS20335	COG1119	ATPase activity
Vp2S01_RS20340	COG0840	transmembrane signaling receptor activity
Vp2S01_RS20365	COG0641	radical SAM
Vp2S01_RS20385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Vp2S01_RS20400	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
Vp2S01_RS20405	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS20410	COG5001	Diguanylate cyclase
Vp2S01_RS20420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Vp2S01_RS20435	COG5413	integral membrane protein
Vp2S01_RS20445	COG1024	Enoyl-CoA hydratase
Vp2S01_RS20450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Vp2S01_RS20455	COG1960	acyl-CoA dehydrogenase activity
Vp2S01_RS20465	COG0183	Belongs to the thiolase family
Vp2S01_RS20480	COG1024	Enoyl-CoA hydratase
Vp2S01_RS20485	COG1024	Enoyl-CoA hydratase
Vp2S01_RS20495	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS20500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Vp2S01_RS20505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Vp2S01_RS20510	COG1845	cytochrome c oxidase, subunit III
Vp2S01_RS20515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Vp2S01_RS20520	COG0109	protoheme IX farnesyltransferase activity
Vp2S01_RS20525	COG1902	pentaerythritol trinitrate reductase activity
Vp2S01_RS20545	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_RS20555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_RS20590	COG1126	abc transporter atp-binding protein
Vp2S01_RS20595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_RS20600	COG4215	(ABC) transporter
Vp2S01_RS20605	COG4160	amino acid transport
Vp2S01_RS20620	COG0625	glutathione transferase activity
Vp2S01_RS20655	COG0443	Heat shock 70 kDa protein
Vp2S01_RS20685	COG4607	ABC-type enterochelin transport system periplasmic component
Vp2S01_RS20690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vp2S01_RS20695	COG4605	iron ion homeostasis
Vp2S01_RS20700	COG4604	ABC transporter, ATP-binding protein
Vp2S01_RS20705	COG0789	Transcriptional regulator
Vp2S01_RS20715	COG2207	Transcriptional regulator
Vp2S01_RS20720	COG4771	TonB-dependent receptor
Vp2S01_RS20720	COG1629	transport
Vp2S01_RS20755	COG1289	transmembrane transporter activity
Vp2S01_RS20760	COG0210	DNA helicase
Vp2S01_RS20765	COG1803	Methylglyoxal synthase
Vp2S01_RS20770	COG1879	ABC-type sugar transport system periplasmic component
Vp2S01_RS20775	COG2205	protein histidine kinase activity
Vp2S01_RS20775	COG2198	Histidine kinase
Vp2S01_RS20775	COG0784	Response regulator, receiver
Vp2S01_RS20790	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS20795	COG3119	arylsulfatase activity
Vp2S01_RS20800	COG3119	arylsulfatase activity
Vp2S01_RS20815	COG3119	arylsulfatase activity
Vp2S01_RS20820	COG0641	radical SAM
Vp2S01_RS20825	COG0714	Associated with various cellular activities
Vp2S01_RS20855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vp2S01_RS20855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vp2S01_RS20860	COG0583	DNA-binding transcription factor activity
Vp2S01_RS20865	COG1597	lipid kinase activity
Vp2S01_RS20870	COG3111	PFAM Bacterial OB fold (BOF) protein
Vp2S01_RS20890	COG0641	radical SAM
Vp2S01_RS20920	COG0501	Belongs to the peptidase M48B family
Vp2S01_RS20925	COG1704	LemA family
Vp2S01_RS20930	COG3069	C4-dicarboxylate transmembrane transporter activity
Vp2S01_RS20940	COG0456	acetyltransferase
Vp2S01_RS20940	COG1214	PFAM Peptidase M22, glycoprotease
Vp2S01_RS20960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Vp2S01_RS20975	COG0641	radical SAM
Vp2S01_RS21010	COG2003	Belongs to the UPF0758 family
Vp2S01_RS21025	COG0235	Class ii aldolase
Vp2S01_RS21030	COG4154	Belongs to the RbsD FucU family
Vp2S01_RS21040	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
Vp2S01_RS21045	COG0738	Major facilitator superfamily
Vp2S01_RS21050	COG1349	DNA-binding transcription factor activity
Vp2S01_RS21095	COG3547	Transposase (IS116 IS110 IS902 family)
Vp2S01_RS21160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Vp2S01_RS21190	COG3547	Transposase (IS116 IS110 IS902 family)
Vp2S01_RS21250	COG1484	DNA-dependent DNA replication
Vp2S01_RS21270	COG0840	transmembrane signaling receptor activity
Vp2S01_RS21290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Vp2S01_RS21365	COG2801	Transposase and inactivated derivatives
Vp2S01_RS21440	COG0457	Tetratricopeptide repeat
Vp2S01_RS21445	COG0477	Major facilitator Superfamily
Vp2S01_RS21445	COG2814	Major facilitator Superfamily
Vp2S01_RS21455	COG1940	carbohydrate kinase activity
Vp2S01_RS21460	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_RS21475	COG0514	ATP-dependent DNA helicase (RecQ)
Vp2S01_RS21505	COG0582	viral genome integration into host DNA
Vp2S01_RS21525	COG2207	Transcriptional regulator
Vp2S01_RS21550	COG4964	Belongs to the GSP D family
Vp2S01_RS21610	COG0583	DNA-binding transcription factor activity
Vp2S01_RS21615	COG0583	DNA-binding transcription factor activity
Vp2S01_RS21630	COG3300	MHYT domain
Vp2S01_RS21630	COG5001	Diguanylate cyclase
Vp2S01_RS21635	COG2197	response regulator
Vp2S01_RS21640	COG3706	GGDEF domain
Vp2S01_RS21650	COG2197	response regulator
Vp2S01_RS21675	COG0835	chemotaxis
Vp2S01_RS21675	COG0784	Response regulator, receiver
Vp2S01_RS21695	COG2962	Rard protein
Vp2S01_RS21710	COG0671	phosphoesterase, PA-phosphatase related
Vp2S01_RS21725	COG2076	Multidrug Resistance protein
Vp2S01_RS21755	COG0471	metal ion transport
Vp2S01_RS21760	COG3290	protein histidine kinase activity
Vp2S01_RS21765	COG4565	transcriptional regulatory protein
Vp2S01_RS21785	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Vp2S01_RS21790	COG5642	Protein of unknown function (DUF2384)
Vp2S01_RS21810	COG1902	pentaerythritol trinitrate reductase activity
Vp2S01_RS21815	COG0346	lactoylglutathione lyase activity
Vp2S01_RS21840	COG2239	Acts as a magnesium transporter
Vp2S01_RS21860	COG0242	peptide deformylase activity
Vp2S01_RS21905	COG2176	DNA-directed DNA polymerase activity
Vp2S01_RS21910	COG0583	DNA-binding transcription factor activity
Vp2S01_RS21915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Vp2S01_RS21920	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Vp2S01_RS21940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Vp2S01_RS21940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Vp2S01_RS21945	COG0509	glycine decarboxylation via glycine cleavage system
Vp2S01_RS21950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vp2S01_RS21990	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Vp2S01_RS21990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_RS21990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_RS21995	COG1105	Belongs to the carbohydrate kinase PfkB family
Vp2S01_RS22000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_RS22000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_RS22005	COG1609	Transcriptional regulator
Vp2S01_RS22025	COG2199	diguanylate cyclase activity
Vp2S01_RS22025	COG2200	EAL domain
Vp2S01_RS22025	COG2203	Gaf domain
Vp2S01_RS22030	COG0765	amino acid transport
Vp2S01_RS22035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_RS22040	COG0765	amino acid transport
Vp2S01_RS22045	COG1126	abc transporter atp-binding protein
Vp2S01_RS22050	COG0469	pyruvate kinase activity
Vp2S01_RS22055	COG2271	Major facilitator Superfamily
Vp2S01_RS22080	COG1979	alcohol dehydrogenase
Vp2S01_RS22085	COG2207	Transcriptional regulator
Vp2S01_RS22100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Vp2S01_RS22105	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Vp2S01_RS22110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_RS22130	COG3437	response regulator, receiver
Vp2S01_RS22130	COG0784	Response regulator, receiver
Vp2S01_RS22140	COG0546	phosphoglycolate phosphatase activity
Vp2S01_RS22150	COG0840	transmembrane signaling receptor activity
Vp2S01_RS22160	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
Vp2S01_RS22165	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS22170	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Vp2S01_RS22185	COG3038	cytochrome b561
Vp2S01_RS22190	COG2353	YceI-like domain
Vp2S01_RS22195	COG2116	formate transmembrane transporter activity
Vp2S01_RS22200	COG0583	DNA-binding transcription factor activity
Vp2S01_RS22210	COG3593	DNA synthesis involved in DNA repair
Vp2S01_RS22215	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_RS22220	COG0861	Integral membrane protein TerC family
Vp2S01_RS22235	COG2267	carboxylic ester hydrolase activity
Vp2S01_RS22240	COG2067	long-chain fatty acid transport protein
Vp2S01_RS22255	COG2050	protein possibly involved in aromatic compounds catabolism
Vp2S01_RS22265	COG4533	DNA binding
Vp2S01_RS22290	COG0484	heat shock protein binding
Vp2S01_RS22300	COG5001	Diguanylate cyclase
Vp2S01_RS22300	COG3300	MHYT domain
Vp2S01_RS22305	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Vp2S01_RS22315	COG4181	ATPase activity
Vp2S01_RS22320	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Vp2S01_RS22330	COG1984	allophanate hydrolase subunit 2
Vp2S01_RS22335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Vp2S01_RS22340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Vp2S01_RS22345	COG3447	MASE1 domain protein
Vp2S01_RS22345	COG5001	Diguanylate cyclase
Vp2S01_RS22345	COG5002	protein histidine kinase activity
Vp2S01_RS22350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Vp2S01_RS22360	COG4771	TonB-dependent receptor
Vp2S01_RS22360	COG1629	transport
Vp2S01_RS22365	COG0583	DNA-binding transcription factor activity
Vp2S01_RS22370	COG1042	CoA-binding domain protein
Vp2S01_RS22370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vp2S01_RS22370	COG0045	succinate-CoA ligase (ADP-forming) activity
Vp2S01_RS22380	COG1181	Belongs to the D-alanine--D-alanine ligase family
Vp2S01_RS22390	COG0023	Translation Initiation Factor
Vp2S01_RS22465	COG0583	DNA-binding transcription factor activity
Vp2S01_RS22475	COG0589	response to stress
Vp2S01_RS22480	COG3140	Belongs to the UPF0181 family
Vp2S01_RS22505	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Vp2S01_RS22510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Vp2S01_RS22535	COG2203	Gaf domain
Vp2S01_RS22535	COG4251	negative regulation of phosphorylation
Vp2S01_RS22535	COG3706	GGDEF domain
Vp2S01_RS22535	COG5001	Diguanylate cyclase
Vp2S01_RS22545	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Vp2S01_RS22550	COG4149	molybdate abc transporter
Vp2S01_RS22555	COG0725	ABC transporter, periplasmic molybdate-binding protein
Vp2S01_RS22560	COG1492	cobalamin metabolic process
Vp2S01_RS22565	COG3111	PFAM Bacterial OB fold (BOF) protein
Vp2S01_RS22575	COG4067	protein conserved in archaea
Vp2S01_RS22575	COG0189	ligase activity
Vp2S01_RS22595	COG0534	Mate efflux family protein
Vp2S01_RS22600	COG0602	queuosine metabolic process
Vp2S01_RS22605	COG1328	CTP reductase activity
Vp2S01_RS22620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_RS22650	COG0243	molybdopterin cofactor binding
Vp2S01_RS22660	COG0583	DNA-binding transcription factor activity
Vp2S01_RS22665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Vp2S01_RS22680	COG2197	response regulator
Vp2S01_RS22685	COG3851	Histidine kinase
Vp2S01_RS22690	COG2271	Major facilitator Superfamily
Vp2S01_RS22715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vp2S01_RS22720	COG3118	belongs to the thioredoxin family
Vp2S01_RS22735	COG0534	Mate efflux family protein
Vp2S01_RS22770	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Vp2S01_RS22790	COG2116	formate transmembrane transporter activity
Vp2S01_RS22800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vp2S01_RS22805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vp2S01_RS22850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vp2S01_RS22850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vp2S01_RS22895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vp2S01_RS22915	COG0277	FAD linked oxidase domain protein
Vp2S01_RS22920	COG0583	DNA-binding transcription factor activity
Vp2S01_RS22955	COG0488	(ABC) transporter
Vp2S01_RS23015	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Vp2S01_RS23030	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Vp2S01_RS23045	COG1288	antiporter activity
Vp2S01_RS23055	COG2814	Major facilitator Superfamily
Vp2S01_RS23065	COG3040	lipid binding
Vp2S01_RS23085	COG0419	ATPase involved in DNA repair
Vp2S01_RS23090	COG0420	3'-5' exonuclease activity
Vp2S01_RS23160	COG0631	protein serine/threonine phosphatase activity
Vp2S01_RS23200	COG2815	serine threonine protein kinase
Vp2S01_RS23200	COG0515	serine threonine protein kinase
Vp2S01_RS23255	COG2146	nitrite reductase [NAD(P)H] activity
Vp2S01_RS23255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vp2S01_RS23260	COG1116	anion transmembrane transporter activity
Vp2S01_RS23265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vp2S01_RS23270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vp2S01_RS23280	COG3707	response regulator
Vp2S01_RS23300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vp2S01_RS23300	COG1648	precorrin-2 dehydrogenase activity
Vp2S01_RS23305	COG0243	molybdopterin cofactor binding
Vp2S01_RS23315	COG0814	amino acid
Vp2S01_RS23345	COG1785	Belongs to the alkaline phosphatase family
Vp2S01_RS23360	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS23380	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Vp2S01_RS23395	COG1609	Transcriptional regulator
Vp2S01_RS23400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_RS23405	COG1879	ABC-type sugar transport system periplasmic component
Vp2S01_RS23410	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vp2S01_RS23415	COG1129	ABC transporter
Vp2S01_RS23420	COG1869	D-ribose catabolic process
Vp2S01_RS23425	COG5001	Diguanylate cyclase
Vp2S01_RS23430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Vp2S01_RS23490	COG0784	Response regulator, receiver
Vp2S01_RS23490	COG2205	protein histidine kinase activity
Vp2S01_RS23510	COG5001	Diguanylate cyclase
Vp2S01_RS23510	COG3300	MHYT domain
Vp2S01_RS23520	COG0330	HflC and HflK could
Vp2S01_RS23535	COG0517	IMP dehydrogenase activity
Vp2S01_RS23535	COG4175	Glycine betaine
Vp2S01_RS23540	COG4176	ABC-type proline glycine betaine transport system permease component
Vp2S01_RS23555	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_RS23560	COG1309	transcriptional regulator
Vp2S01_RS23565	COG3706	GGDEF domain
Vp2S01_RS23575	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS23590	COG1024	Enoyl-CoA hydratase
Vp2S01_RS23595	COG1960	acyl-CoA dehydrogenase activity
Vp2S01_RS23605	COG0183	Belongs to the thiolase family
Vp2S01_RS23615	COG1960	acyl-CoA dehydrogenase activity
Vp2S01_RS23620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Vp2S01_RS23640	COG4999	Histidine kinase
Vp2S01_RS23640	COG2205	protein histidine kinase activity
Vp2S01_RS23640	COG3850	Histidine kinase
Vp2S01_RS23640	COG3437	response regulator, receiver
Vp2S01_RS23655	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Vp2S01_RS23655	COG3264	Mechanosensitive ion channel
Vp2S01_RS23665	COG0110	maltose O-acetyltransferase activity
Vp2S01_RS23670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_RS23675	COG1271	oxidase subunit
Vp2S01_RS23680	COG1294	oxidase, subunit
Vp2S01_RS23690	COG0384	phenazine biosynthesis protein PhzF
Vp2S01_RS23695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Vp2S01_RS23700	COG0789	Transcriptional regulator
Vp2S01_RS23710	COG3474	cytochrome
Vp2S01_RS23720	COG0500	methyltransferase
Vp2S01_RS23780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vp2S01_RS23785	COG0516	GMP reductase activity
Vp2S01_RS23790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Vp2S01_RS23790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Vp2S01_RS23805	COG4989	oxidoreductase activity
Vp2S01_RS23820	COG0038	chloride channel
Vp2S01_RS23830	COG1914	H( )-stimulated, divalent metal cation uptake system
Vp2S01_RS23835	COG0302	gtp cyclohydrolase
Vp2S01_RS23845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vp2S01_RS23865	COG2897	thiosulfate sulfurtransferase activity
Vp2S01_RS23895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Vp2S01_RS23900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Vp2S01_RS23905	COG0840	transmembrane signaling receptor activity
Vp2S01_RS23915	COG2814	Major facilitator Superfamily
Vp2S01_RS23920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vp2S01_RS23935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vp2S01_RS23945	COG0840	transmembrane signaling receptor activity
Vp2S01_RS23965	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vp2S01_RS23980	COG2197	response regulator
Vp2S01_RS23985	COG3850	Histidine kinase
Vp2S01_RS23990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vp2S01_RS24000	COG0243	molybdopterin cofactor binding
Vp2S01_RS24010	COG3005	denitrification pathway
Vp2S01_RS24030	COG0183	Belongs to the thiolase family
Vp2S01_RS24050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vp2S01_RS24055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vp2S01_RS24085	COG1522	sequence-specific DNA binding
Vp2S01_RS24105	COG1566	PFAM secretion protein HlyD family protein
Vp2S01_RS24115	COG2205	protein histidine kinase activity
Vp2S01_RS24115	COG0784	Response regulator, receiver
Vp2S01_RS24120	COG1879	ABC-type sugar transport system periplasmic component
Vp2S01_RS24125	COG2827	Endonuclease containing a URI domain
Vp2S01_RS24130	COG3132	Protein of unknown function, DUF480
Vp2S01_RS24145	COG2926	Belongs to the UPF0265 family
Vp2S01_RS24150	COG0534	Mate efflux family protein
Vp2S01_RS24155	COG0673	inositol 2-dehydrogenase activity
Vp2S01_RS24160	COG0784	Response regulator, receiver
Vp2S01_RS24160	COG2205	protein histidine kinase activity
Vp2S01_RS24160	COG5002	protein histidine kinase activity
Vp2S01_RS24185	COG1522	sequence-specific DNA binding
Vp2S01_RS24195	COG0531	amino acid
Vp2S01_RS24210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Vp2S01_RS24215	COG2239	Acts as a magnesium transporter
Vp2S01_RS24225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Vp2S01_RS24230	COG0402	S-adenosylhomocysteine deaminase activity
Vp2S01_RS24240	COG1418	mRNA catabolic process
Vp2S01_RS24255	COG2814	Major facilitator Superfamily
Vp2S01_RS24265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vp2S01_RS24285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vp2S01_RS24305	COG4221	oxidoreductase activity
Vp2S01_RS24310	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS24315	COG2205	protein histidine kinase activity
Vp2S01_RS24325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Vp2S01_RS24330	COG2194	sulfuric ester hydrolase activity
Vp2S01_RS24335	COG0673	inositol 2-dehydrogenase activity
Vp2S01_RS24345	COG2814	Major facilitator Superfamily
Vp2S01_RS24370	COG4667	esterase of the alpha-beta hydrolase superfamily
Vp2S01_RS24375	COG1741	Belongs to the pirin family
Vp2S01_RS24380	COG1278	Cold shock
Vp2S01_RS24400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Vp2S01_RS24420	COG1686	Belongs to the peptidase S11 family
Vp2S01_RS24435	COG0625	glutathione transferase activity
Vp2S01_RS24470	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_RS24490	COG3746	phosphate-selective porin O and P
Vp2S01_RS24510	COG3833	ABC-type maltose transport systems, permease component
Vp2S01_RS24515	COG1175	transmembrane transport
Vp2S01_RS24525	COG3842	ATPase activity
Vp2S01_RS24555	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_RS24585	COG3097	Belongs to the UPF0267 family
Vp2S01_RS24590	COG1309	transcriptional regulator
Vp2S01_RS24595	COG2130	NADP-dependent
Vp2S01_RS24605	COG0753	catalase activity
Vp2S01_RS24610	COG2084	Dehydrogenase
Vp2S01_RS24615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_RS24620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_RS24630	COG2207	Transcriptional regulator
Vp2S01_RS24635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_RS24635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_RS24635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_RS24650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vp2S01_RS24655	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Vp2S01_RS24665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vp2S01_RS24670	COG0569	domain protein
Vp2S01_RS24680	COG2205	protein histidine kinase activity
Vp2S01_RS24685	COG1132	(ABC) transporter
Vp2S01_RS24690	COG4774	siderophore transport
Vp2S01_RS24695	COG1120	ATPase activity
Vp2S01_RS24700	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Vp2S01_RS24750	COG2197	response regulator
Vp2S01_RS24760	COG0840	transmembrane signaling receptor activity
Vp2S01_RS24770	COG0714	Associated with various cellular activities
Vp2S01_RS24790	COG2304	oxidoreductase activity
Vp2S01_RS24805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Vp2S01_RS24810	COG0581	inorganic phosphate transmembrane transporter activity
Vp2S01_RS24815	COG0573	inorganic phosphate transmembrane transporter activity
Vp2S01_RS24845	COG4771	TonB-dependent receptor
Vp2S01_RS24850	COG1770	oligopeptidase
Vp2S01_RS24855	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS24865	COG1376	ErfK ybiS ycfS ynhG family protein
Vp2S01_RS24865	COG1388	LysM domain
Vp2S01_RS24870	COG0415	Belongs to the DNA photolyase family
Vp2S01_RS24875	COG0789	Transcriptional regulator
Vp2S01_RS24880	COG3272	Protein of unknown function (DUF1722)
Vp2S01_RS24890	COG0813	purine-nucleoside phosphorylase activity
Vp2S01_RS24905	COG3706	GGDEF domain
Vp2S01_RS24915	COG1566	PFAM secretion protein HlyD family protein
Vp2S01_RS24920	COG4720	Psort location CytoplasmicMembrane, score
Vp2S01_RS24925	COG1122	ATPase activity
Vp2S01_RS24940	COG0348	domain, Protein
Vp2S01_RS24945	COG0437	4 iron, 4 sulfur cluster binding
Vp2S01_RS24950	COG1247	-acetyltransferase
Vp2S01_RS24980	COG1067	ATP-dependent peptidase activity
Vp2S01_RS24990	COG4172	Belongs to the ABC transporter superfamily
Vp2S01_RS24995	COG1505	serine-type exopeptidase activity
Vp2S01_RS25000	COG0583	DNA-binding transcription factor activity
Vp2S01_RS25005	COG1620	l-lactate permease
Vp2S01_RS25010	COG1304	FMN binding
Vp2S01_RS25020	COG0668	transmembrane transport
Vp2S01_RS25060	COG1063	alcohol dehydrogenase
Vp2S01_RS25065	COG0156	8-amino-7-oxononanoate synthase activity
Vp2S01_RS25075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_RS25095	COG0745	RESPONSE REGULATOR receiver
Vp2S01_RS25130	COG0346	lactoylglutathione lyase activity
Vp2S01_RS25150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Vp2S01_RS25230	COG1987	bacterial-type flagellum assembly
Vp2S01_RS25240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Vp2S01_RS25255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_RS25265	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Vp2S01_RS25270	COG1516	flagellar protein fliS
Vp2S01_RS25285	COG1580	Controls the rotational direction of flagella during chemotaxis
Vp2S01_RS25290	COG1191	sigma factor activity
Vp2S01_RS25295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Vp2S01_RS25300	COG1360	Flagellar Motor Protein
Vp2S01_RS25330	COG1882	Formate acetyltransferase
Vp2S01_RS25335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vp2S01_RS25340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Vp2S01_RS25350	COG0454	-acetyltransferase
Vp2S01_RS25365	COG2814	Major facilitator Superfamily
Vp2S01_RS25390	COG1538	Outer membrane efflux protein
Vp2S01_RS25410	COG0628	permease
Vp2S01_RS25415	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Vp2S01_RS25425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vp2S01_RS25435	COG4628	conserved protein (DUF2132)
Vp2S01_RS25440	COG0583	DNA-binding transcription factor activity
Vp2S01_RS25465	COG1686	Belongs to the peptidase S11 family
Vp2S01_RS25480	COG1054	Belongs to the UPF0176 family
Vp2S01_RS25485	COG3397	chitin binding
Vp2S01_RS25490	COG4667	esterase of the alpha-beta hydrolase superfamily
Vp2S01_RS25495	COG2095	MarC family integral membrane protein
Vp2S01_RS25515	COG3206	protein involved in exopolysaccharide biosynthesis
Vp2S01_RS25515	COG0489	protein tyrosine kinase activity
Vp2S01_RS25530	COG0583	DNA-binding transcription factor activity
Vp2S01_RS25540	COG1301	dicarboxylic acid transport
Vp2S01_RS25545	COG3339	Conserved Protein
Vp2S01_RS25550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vp2S01_RS25555	COG0700	Nucleoside recognition
Vp2S01_RS25560	COG3366	ferrous iron transmembrane transporter activity
Vp2S01_RS25575	COG0366	Alpha amylase catalytic
Vp2S01_RS25580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Vp2S01_RS25585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Vp2S01_RS25590	COG1640	4-alpha-glucanotransferase
Vp2S01_RS25595	COG0058	SHG alpha-glucan phosphorylase activity
Vp2S01_RS25610	COG2909	trisaccharide binding
Vp2S01_RS25625	COG1999	signal sequence binding
Vp2S01_RS25635	COG1263	PTS System
Vp2S01_RS25635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_RS25640	COG1162	GTPase activity
Vp2S01_RS25645	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Vp2S01_RS25655	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Vp2S01_RS25665	COG0531	amino acid
Vp2S01_RS25670	COG1982	Orn Lys Arg decarboxylase major
Vp2S01_RS25690	COG2356	endonuclease I
Vp2S01_RS25715	COG4580	involved in the transport of maltose and maltodextrins
Vp2S01_RS25740	COG0739	heme binding
Vp2S01_RS25750	COG0612	Peptidase, M16
Vp2S01_RS25755	COG0840	transmembrane signaling receptor activity
Vp2S01_RS25760	COG1120	ATPase activity
Vp2S01_RS25765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vp2S01_RS25770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vp2S01_RS25775	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Vp2S01_RS25780	COG4772	TonB-dependent receptor
Vp2S01_RS25805	COG4264	IucA IucC family
Vp2S01_RS25810	COG0019	diaminopimelate decarboxylase activity
Vp2S01_RS25815	COG1653	transport
Vp2S01_RS25845	COG0826	peptidase U32
Vp2S01_RS25850	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vp2S01_RS25855	COG1129	ABC transporter
Vp2S01_RS25860	COG1879	ABC-type sugar transport system periplasmic component
Vp2S01_RS25865	COG1069	ribulokinase activity
Vp2S01_RS25875	COG2160	L-arabinose isomerase activity
Vp2S01_RS25900	COG1764	response to oxidative stress
Vp2S01_RS25905	COG1846	Transcriptional regulator
Vp2S01_RS25915	COG3634	alkyl hydroperoxide reductase activity
Vp2S01_RS25950	COG1595	DNA-templated transcription, initiation
Vp2S01_RS25970	COG0583	DNA-binding transcription factor activity
Vp2S01_RS25975	COG1486	melibiose metabolic process
Vp2S01_RS25990	COG2258	MOSC domain
Vp2S01_RS25995	COG0513	Belongs to the DEAD box helicase family
Vp2S01_RS26000	COG1312	Catalyzes the dehydration of D-mannonate
Vp2S01_RS26005	COG2186	Transcriptional regulator
Vp2S01_RS26015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vp2S01_RS26025	COG0246	Mannitol dehydrogenase
Vp2S01_RS26030	COG1904	glucuronate isomerase
Vp2S01_RS26035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_RS26040	COG0800	Aldolase
Vp2S01_RS26065	COG2207	Transcriptional regulator
Vp2S01_RS26075	COG1132	(ABC) transporter
Vp2S01_RS26120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vp2S01_RS26150	COG0259	pyridoxamine-phosphate oxidase activity
Vp2S01_RS26205	COG4166	transmembrane transport
Vp2S01_RS26225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Vp2S01_RS26230	COG1263	PTS System
Vp2S01_RS26230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_RS26235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Vp2S01_RS26240	COG3340	Belongs to the peptidase S51 family
Vp2S01_RS26260	COG1444	tRNA N-acetyltransferase activity
Vp2S01_RS26290	COG4608	Belongs to the ABC transporter superfamily
Vp2S01_RS26295	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_RS26305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vp2S01_RS26305	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
Vp2S01_RS26330	COG0217	transcriptional regulatory protein
Vp2S01_RS26335	COG0772	Belongs to the SEDS family
Vp2S01_RS26350	COG1136	(ABC) transporter
Vp2S01_RS26375	COG1192	Involved in chromosome partitioning
Vp2S01_RS26400	COG0419	ATPase involved in DNA repair
Vp2S01_RS26680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vp2S01_RS26715	COG3504	Conjugal transfer protein
Vp2S01_RS26730	COG4962	Type ii secretion system protein e
Vp2S01_RS26740	COG3451	type IV secretory pathway VirB4
Vp2S01_RS26745	COG5268	conjugation
Vp2S01_RS26800	COG0616	signal peptide processing