locus-tag	class	description
GPY45_RS00015	COG1252	NADH dehydrogenase
GPY45_RS00025	COG3150	esterase
GPY45_RS00050	COG0537	adenosine 5'-monophosphoramidase activity
GPY45_RS00080	COG0516	GMP reductase activity
GPY45_RS00080	COG0517	IMP dehydrogenase activity
GPY45_RS00090	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY45_RS00095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY45_RS00100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY45_RS00110	COG2199	diguanylate cyclase activity
GPY45_RS00125	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY45_RS00130	COG1946	Acyl-CoA thioesterase
GPY45_RS00140	COG1522	sequence-specific DNA binding
GPY45_RS00170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY45_RS00175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS00220	COG0477	Major facilitator Superfamily
GPY45_RS00225	COG2855	membrane
GPY45_RS00240	COG1441	menaquinone biosynthetic process
GPY45_RS00245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY45_RS00250	COG0596	Alpha beta hydrolase
GPY45_RS00255	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY45_RS00260	COG1169	isochorismate synthase
GPY45_RS00265	COG0436	Aminotransferase
GPY45_RS00270	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY45_RS00275	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY45_RS00290	COG1555	photosystem II stabilization
GPY45_RS00295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY45_RS00300	COG0776	regulation of translation
GPY45_RS00305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY45_RS00310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY45_RS00315	COG0740	serine-type endopeptidase activity
GPY45_RS00320	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY45_RS00330	COG2204	response regulator
GPY45_RS00340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY45_RS00345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY45_RS00350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY45_RS00355	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY45_RS00375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY45_RS00380	COG0569	domain protein
GPY45_RS00385	COG0513	Belongs to the DEAD box helicase family
GPY45_RS00390	COG1253	flavin adenine dinucleotide binding
GPY45_RS00425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY45_RS00430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY45_RS00450	COG1216	Glycosyl transferase, family 2
GPY45_RS00455	COG2986	histidine ammonia-lyase
GPY45_RS00480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY45_RS00485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY45_RS00535	COG0582	viral genome integration into host DNA
GPY45_RS00545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY45_RS00550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY45_RS00555	COG0583	DNA-binding transcription factor activity
GPY45_RS00560	COG2951	lytic endotransglycosylase activity
GPY45_RS00565	COG3100	YcgL domain-containing protein
GPY45_RS00570	COG0850	regulation of cytokinetic process
GPY45_RS00575	COG2894	cell division
GPY45_RS00580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY45_RS00585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY45_RS00590	COG0318	PFAM AMP-dependent synthetase and ligase
GPY45_RS00595	COG2267	carboxylic ester hydrolase activity
GPY45_RS00610	COG1214	PFAM Peptidase M22, glycoprotease
GPY45_RS00615	COG1199	ATP-dependent helicase activity
GPY45_RS00620	COG0788	formyltetrahydrofolate deformylase activity
GPY45_RS00625	COG3102	Protein conserved in bacteria
GPY45_RS00635	COG0018	arginyl-trna synthetase
GPY45_RS00655	COG1918	ferrous iron import across plasma membrane
GPY45_RS00670	COG4977	sequence-specific DNA binding
GPY45_RS00675	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY45_RS00680	COG1121	(ABC) transporter
GPY45_RS00685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY45_RS00695	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY45_RS00700	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY45_RS00705	COG0567	Dehydrogenase, E1 component
GPY45_RS00710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY45_RS00715	COG1053	succinate dehydrogenase
GPY45_RS00720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY45_RS00725	COG2009	succinate dehydrogenase
GPY45_RS00735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY45_RS00745	COG0033	Phosphoglucomutase
GPY45_RS00750	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY45_RS00755	COG0596	Alpha beta hydrolase
GPY45_RS00765	COG0716	FMN binding
GPY45_RS00775	COG0735	belongs to the Fur family
GPY45_RS00780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY45_RS00785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY45_RS00785	COG2190	(PTS) system
GPY45_RS00785	COG1263	PTS System
GPY45_RS00795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY45_RS00800	COG1940	carbohydrate kinase activity
GPY45_RS00800	COG1846	Transcriptional regulator
GPY45_RS00805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY45_RS00805	COG4651	solute:proton antiporter activity
GPY45_RS00810	COG0367	asparagine synthase
GPY45_RS00815	COG0250	Participates in transcription elongation, termination and antitermination
GPY45_RS00820	COG3104	oligopeptide transport
GPY45_RS00825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY45_RS00830	COG0563	adenylate kinase activity
GPY45_RS00835	COG0326	Molecular chaperone. Has ATPase activity
GPY45_RS00840	COG3710	Transcriptional regulator
GPY45_RS00860	COG0622	Phosphoesterase
GPY45_RS00890	COG1090	epimerase
GPY45_RS00895	COG0300	oxidoreductase activity
GPY45_RS00905	COG3118	belongs to the thioredoxin family
GPY45_RS00910	COG0330	HflC and HflK could
GPY45_RS00935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY45_RS00940	COG3115	cell septum assembly
GPY45_RS00945	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY45_RS00950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY45_RS00960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY45_RS00965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY45_RS00970	COG2190	(PTS) system
GPY45_RS00980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS00985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS00995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS01005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS01015	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY45_RS01015	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY45_RS01020	COG1706	bacterial-type flagellum-dependent cell motility
GPY45_RS01025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY45_RS01030	COG4786	Flagellar basal body rod
GPY45_RS01035	COG4787	bacterial-type flagellum-dependent cell motility
GPY45_RS01045	COG1749	Flagellar hook protein flgE
GPY45_RS01050	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY45_RS01055	COG1558	bacterial-type flagellum-dependent cell motility
GPY45_RS01060	COG1815	bacterial-type flagellum-dependent cell motility
GPY45_RS01065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY45_RS01070	COG0784	Response regulator, receiver
GPY45_RS01070	COG0835	chemotaxis
GPY45_RS01130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY45_RS01135	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY45_RS01150	COG2217	Heavy metal translocating P-type atpase
GPY45_RS01150	COG2608	mercury ion transmembrane transporter activity
GPY45_RS01190	COG2840	Smr protein MutS2
GPY45_RS01195	COG1187	pseudouridine synthase activity
GPY45_RS01200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY45_RS01205	COG0737	Belongs to the 5'-nucleotidase family
GPY45_RS01210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY45_RS01215	COG2912	Transglutaminase-like superfamily
GPY45_RS01220	COG3094	Invasion gene expression up-regulator, SirB
GPY45_RS01225	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY45_RS01230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY45_RS01235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY45_RS01240	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY45_RS01245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY45_RS01250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY45_RS01255	COG0193	aminoacyl-tRNA hydrolase activity
GPY45_RS01260	COG0012	GTP binding
GPY45_RS01370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY45_RS01380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY45_RS01385	COG1702	phosphate starvation-inducible protein PhoH
GPY45_RS01390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY45_RS01395	COG4535	Mg2 and Co2 transporter CorC
GPY45_RS01400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY45_RS01405	COG2888	peptidyl-tyrosine sulfation
GPY45_RS01410	COG0495	leucyl-tRNA aminoacylation
GPY45_RS01415	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY45_RS01420	COG1466	dna polymerase III delta subunit
GPY45_RS01425	COG0799	negative regulation of ribosome biogenesis
GPY45_RS01430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY45_RS01435	COG0768	penicillin binding
GPY45_RS01440	COG0772	Belongs to the SEDS family
GPY45_RS01445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY45_RS01450	COG1686	Belongs to the peptidase S11 family
GPY45_RS01455	COG2921	Belongs to the UPF0250 family
GPY45_RS01460	COG0321	lipoyl(octanoyl) transferase activity
GPY45_RS01465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY45_RS01470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY45_RS01475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY45_RS01490	COG0366	Alpha amylase catalytic
GPY45_RS01495	COG1263	PTS System
GPY45_RS01495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY45_RS01505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY45_RS01515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY45_RS01520	COG2011	ABC-type metal ion transport system permease component
GPY45_RS01525	COG1464	Belongs to the NlpA lipoprotein family
GPY45_RS01530	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY45_RS01540	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY45_RS01540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY45_RS01550	COG0745	RESPONSE REGULATOR receiver
GPY45_RS01550	COG3706	GGDEF domain
GPY45_RS01555	COG1611	Belongs to the LOG family
GPY45_RS01560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY45_RS01570	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GPY45_RS01575	COG2363	Small membrane protein
GPY45_RS01585	COG0583	DNA-binding transcription factor activity
GPY45_RS01590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY45_RS01590	COG0301	tRNA thio-modification
GPY45_RS01595	COG2885	chlorophyll binding
GPY45_RS01600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY45_RS01605	COG1722	exodeoxyribonuclease VII activity
GPY45_RS01610	COG0142	geranyltranstransferase activity
GPY45_RS01615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY45_RS01620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY45_RS01625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY45_RS01630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY45_RS01650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY45_RS01650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY45_RS01655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY45_RS01660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY45_RS01665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY45_RS01680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY45_RS01685	COG2252	PERMEase
GPY45_RS01690	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY45_RS01725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY45_RS01735	COG0590	tRNA wobble adenosine to inosine editing
GPY45_RS01740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY45_RS01780	COG0484	heat shock protein binding
GPY45_RS01785	COG0443	Heat shock 70 kDa protein
GPY45_RS01795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY45_RS01800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY45_RS01810	COG0497	DNA recombination
GPY45_RS01815	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY45_RS01820	COG2914	Belongs to the UPF0125 (RnfH) family
GPY45_RS01825	COG2867	negative regulation of translational initiation
GPY45_RS01830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY45_RS01850	COG0583	DNA-binding transcription factor activity
GPY45_RS01855	COG3153	acetyltransferase
GPY45_RS01855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY45_RS01875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY45_RS01880	COG2873	o-acetylhomoserine
GPY45_RS01915	COG1115	amino acid carrier protein
GPY45_RS01925	COG1584	GPR1 FUN34 yaaH family protein
GPY45_RS01935	COG1757	Na H antiporter
GPY45_RS02015	COG0582	viral genome integration into host DNA
GPY45_RS02020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY45_RS02020	COG0519	Catalyzes the synthesis of GMP from XMP
GPY45_RS02025	COG0516	GMP reductase activity
GPY45_RS02025	COG0517	IMP dehydrogenase activity
GPY45_RS02030	COG1570	exodeoxyribonuclease VII activity
GPY45_RS02045	COG1160	GTP binding
GPY45_RS02050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY45_RS02055	COG2976	Protein conserved in bacteria
GPY45_RS02060	COG0124	histidyl-tRNA synthetase
GPY45_RS02065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY45_RS02080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY45_RS02085	COG0105	UTP biosynthetic process
GPY45_RS02090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY45_RS02095	COG2975	iron-sulfur cluster assembly
GPY45_RS02100	COG0633	Ferredoxin
GPY45_RS02105	COG0443	Heat shock 70 kDa protein
GPY45_RS02110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY45_RS02120	COG0822	iron-sulfur transferase activity
GPY45_RS02125	COG1104	cysteine desulfurase activity
GPY45_RS02135	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY45_RS02140	COG0483	inositol monophosphate 1-phosphatase activity
GPY45_RS02150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY45_RS02155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY45_RS02160	COG1862	Preprotein translocase
GPY45_RS02165	COG0343	queuine tRNA-ribosyltransferase activity
GPY45_RS02170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY45_RS02180	COG0517	IMP dehydrogenase activity
GPY45_RS02190	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY45_RS02200	COG0583	DNA-binding transcription factor activity
GPY45_RS02205	COG0450	alkyl hydroperoxide reductase
GPY45_RS02210	COG3142	Participates in the control of copper homeostasis
GPY45_RS02220	COG0704	Plays a role in the regulation of phosphate uptake
GPY45_RS02225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY45_RS02230	COG0581	inorganic phosphate transmembrane transporter activity
GPY45_RS02245	COG0248	Ppx GppA phosphatase
GPY45_RS02255	COG5002	protein histidine kinase activity
GPY45_RS02260	COG0745	RESPONSE REGULATOR receiver
GPY45_RS02265	COG2974	May be involved in recombination
GPY45_RS02275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY45_RS02335	COG0542	response to heat
GPY45_RS02345	COG0564	pseudouridine synthase activity
GPY45_RS02350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY45_RS02360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY45_RS02365	COG0077	Prephenate dehydratase
GPY45_RS02365	COG1605	Chorismate mutase
GPY45_RS02370	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY45_RS02375	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY45_RS02385	COG0488	(ABC) transporter
GPY45_RS02400	COG0739	heme binding
GPY45_RS02405	COG0287	Prephenate dehydrogenase
GPY45_RS02405	COG1605	Chorismate mutase
GPY45_RS02410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY45_RS02415	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY45_RS02420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY45_RS02425	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY45_RS02440	COG1966	Carbon starvation protein
GPY45_RS02445	COG3275	phosphorelay sensor kinase activity
GPY45_RS02450	COG3279	Response regulator of the LytR AlgR family
GPY45_RS02455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY45_RS02460	COG1047	Peptidyl-prolyl cis-trans
GPY45_RS02465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY45_RS02470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY45_RS02475	COG0196	riboflavin kinase activity
GPY45_RS02480	COG0728	peptidoglycan biosynthetic process
GPY45_RS02485	COG0268	Binds directly to 16S ribosomal RNA
GPY45_RS02495	COG0640	Transcriptional regulator
GPY45_RS02505	COG0583	DNA-binding transcription factor activity
GPY45_RS02510	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY45_RS02520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY45_RS02525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY45_RS02530	COG0730	response to heat
GPY45_RS02540	COG0494	nUDIX hydrolase
GPY45_RS02550	COG3066	DNA modification
GPY45_RS02560	COG0667	Aldo Keto reductase
GPY45_RS02575	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY45_RS02585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY45_RS02590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY45_RS02600	COG0716	FMN binding
GPY45_RS02610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY45_RS02615	COG0513	Belongs to the DEAD box helicase family
GPY45_RS02620	COG3022	response to hydroperoxide
GPY45_RS02625	COG1115	amino acid carrier protein
GPY45_RS02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY45_RS02650	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY45_RS02655	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY45_RS02660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY45_RS02665	COG0083	homoserine kinase activity
GPY45_RS02680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY45_RS02695	COG0745	RESPONSE REGULATOR receiver
GPY45_RS02705	COG5002	protein histidine kinase activity
GPY45_RS02705	COG2198	Histidine kinase
GPY45_RS02705	COG0784	Response regulator, receiver
GPY45_RS02710	COG5001	Diguanylate cyclase
GPY45_RS02710	COG2203	Gaf domain
GPY45_RS02710	COG3706	GGDEF domain
GPY45_RS02710	COG4251	negative regulation of phosphorylation
GPY45_RS02715	COG1242	4 iron, 4 sulfur cluster binding
GPY45_RS02720	COG0070	glutamate synthase
GPY45_RS02720	COG0069	glutamate synthase activity
GPY45_RS02720	COG0067	glutamate synthase
GPY45_RS02730	COG0067	glutamate synthase
GPY45_RS02730	COG0069	glutamate synthase activity
GPY45_RS02730	COG0070	glutamate synthase
GPY45_RS02735	COG0493	'glutamate synthase
GPY45_RS02745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY45_RS02755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY45_RS02765	COG0583	DNA-binding transcription factor activity
GPY45_RS02770	COG0730	response to heat
GPY45_RS02785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY45_RS02790	COG0505	Belongs to the CarA family
GPY45_RS02795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY45_RS02800	COG0494	nUDIX hydrolase
GPY45_RS02805	COG0653	protein targeting
GPY45_RS02815	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY45_RS02820	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY45_RS02825	COG0849	cell division
GPY45_RS02830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY45_RS02835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY45_RS02840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY45_RS02845	COG0772	Belongs to the SEDS family
GPY45_RS02850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY45_RS02855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY45_RS02860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY45_RS02865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY45_RS02870	COG0768	penicillin binding
GPY45_RS02875	COG3116	cell division
GPY45_RS02880	COG0275	rRNA processing
GPY45_RS02895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY45_RS02905	COG0792	nuclease activity
GPY45_RS02910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY45_RS02915	COG2823	Periplasmic or secreted lipoprotein
GPY45_RS02920	COG2969	positive regulation of protein catabolic process
GPY45_RS02925	COG0625	glutathione transferase activity
GPY45_RS02930	COG2857	Cytochrome c1
GPY45_RS02935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY45_RS02940	COG0723	plastoquinol--plastocyanin reductase activity
GPY45_RS02945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY45_RS02950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY45_RS02960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY45_RS02970	COG3105	Protein conserved in bacteria
GPY45_RS02980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY45_RS02995	COG3150	esterase
GPY45_RS03005	COG3151	Protein conserved in bacteria
GPY45_RS03010	COG0494	nUDIX hydrolase
GPY45_RS03015	COG1538	Outer membrane efflux protein
GPY45_RS03020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY45_RS03020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY45_RS03025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY45_RS03040	COG3025	triphosphatase activity
GPY45_RS03045	COG1392	Phosphate transport regulator
GPY45_RS03050	COG0306	phosphate transporter
GPY45_RS03055	COG4991	sh3 domain protein
GPY45_RS03065	COG3267	Type II secretory pathway component ExeA
GPY45_RS03065	COG3409	Peptidoglycan-binding domain 1 protein
GPY45_RS03070	COG0617	tRNA 3'-terminal CCA addition
GPY45_RS03075	COG1968	undecaprenyl-diphosphatase activity
GPY45_RS03080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY45_RS03085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY45_RS03090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY45_RS03095	COG0596	Alpha beta hydrolase
GPY45_RS03100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY45_RS03105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY45_RS03110	COG1610	YqeY-like protein
GPY45_RS03115	COG0358	DNA primase activity
GPY45_RS03120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY45_RS03130	COG1464	Belongs to the NlpA lipoprotein family
GPY45_RS03140	COG2207	Transcriptional regulator
GPY45_RS03175	COG2213	PTS system mannitol-specific
GPY45_RS03175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY45_RS03180	COG0246	Mannitol dehydrogenase
GPY45_RS03185	COG3722	fumarate hydratase activity
GPY45_RS03190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY45_RS03195	COG5002	protein histidine kinase activity
GPY45_RS03210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY45_RS03215	COG1349	DNA-binding transcription factor activity
GPY45_RS03225	COG0469	pyruvate kinase activity
GPY45_RS03235	COG3706	GGDEF domain
GPY45_RS03240	COG0440	acetolactate synthase activity
GPY45_RS03245	COG0028	Belongs to the TPP enzyme family
GPY45_RS03250	COG1022	Amp-dependent synthetase and ligase
GPY45_RS03255	COG0583	DNA-binding transcription factor activity
GPY45_RS03275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY45_RS03280	COG0473	3-isopropylmalate dehydrogenase activity
GPY45_RS03285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY45_RS03290	COG0066	3-isopropylmalate dehydratase activity
GPY45_RS03300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY45_RS03305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY45_RS03310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY45_RS03315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY45_RS03320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY45_RS03325	COG2967	ApaG domain
GPY45_RS03330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY45_RS03345	COG2966	Psort location CytoplasmicMembrane, score
GPY45_RS03360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY45_RS03365	COG0142	geranyltranstransferase activity
GPY45_RS03375	COG0039	L-malate dehydrogenase activity
GPY45_RS03410	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY45_RS03415	COG1178	ABC-type Fe3 transport system permease component
GPY45_RS03420	COG4143	(ABC) transporter
GPY45_RS03425	COG0163	prenyltransferase activity
GPY45_RS03430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY45_RS03440	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY45_RS03445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY45_RS03455	COG2105	PFAM AIG2 family protein
GPY45_RS03465	COG0729	surface antigen
GPY45_RS03470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY45_RS03480	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY45_RS03495	COG4181	ATPase activity
GPY45_RS03515	COG0529	Catalyzes the synthesis of activated sulfate
GPY45_RS03530	COG2895	sulfate adenylyltransferase (ATP) activity
GPY45_RS03535	COG0175	sulfate reduction
GPY45_RS03540	COG1648	precorrin-2 dehydrogenase activity
GPY45_RS03540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY45_RS03545	COG0737	Belongs to the 5'-nucleotidase family
GPY45_RS03555	COG0513	Belongs to the DEAD box helicase family
GPY45_RS03560	COG2153	protein acetylation
GPY45_RS03570	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY45_RS03580	COG0203	ribosomal protein L17
GPY45_RS03585	COG0202	RNA polymerase activity
GPY45_RS03595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY45_RS03600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY45_RS03610	COG0201	protein transport
GPY45_RS03615	COG0200	Binds to the 23S rRNA
GPY45_RS03620	COG1841	ribosomal large subunit assembly
GPY45_RS03635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY45_RS03640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY45_RS03645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY45_RS03650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY45_RS03655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY45_RS03660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY45_RS03665	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY45_RS03670	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY45_RS03680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY45_RS03685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY45_RS03690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY45_RS03695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY45_RS03705	COG0088	Forms part of the polypeptide exit tunnel
GPY45_RS03710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY45_RS03720	COG0254	rRNA binding
GPY45_RS03730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY45_RS03735	COG1609	Transcriptional regulator
GPY45_RS03745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY45_RS03750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY45_RS03755	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY45_RS03760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY45_RS03765	COG3074	FtsZ-dependent cytokinesis
GPY45_RS03775	COG1494	fructose-1,6-bisphosphatase
GPY45_RS03800	COG0149	triose-phosphate isomerase activity
GPY45_RS03805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY45_RS03815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY45_RS03820	COG1482	cell wall glycoprotein biosynthetic process
GPY45_RS03855	COG1086	Polysaccharide biosynthesis protein
GPY45_RS03880	COG1090	epimerase
GPY45_RS03885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY45_RS03925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY45_RS03935	COG1560	Kdo2-lipid A biosynthetic process
GPY45_RS03940	COG0859	PFAM glycosyl transferase family 9
GPY45_RS03945	COG1519	Transferase
GPY45_RS03955	COG0438	transferase activity, transferring glycosyl groups
GPY45_RS03955	COG0297	glycogen (starch) synthase activity
GPY45_RS03975	COG2030	dehydratase
GPY45_RS03980	COG0110	maltose O-acetyltransferase activity
GPY45_RS04000	COG3642	lipopolysaccharide core region biosynthetic process
GPY45_RS04005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY45_RS04010	COG0859	PFAM glycosyl transferase family 9
GPY45_RS04015	COG0463	Glycosyl transferase, family 2
GPY45_RS04030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY45_RS04035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY45_RS04050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY45_RS04055	COG2003	Belongs to the UPF0758 family
GPY45_RS04070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY45_RS04075	COG1309	transcriptional regulator
GPY45_RS04080	COG1560	Kdo2-lipid A biosynthetic process
GPY45_RS04085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY45_RS04090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY45_RS04095	COG1561	YicC-like family, N-terminal region
GPY45_RS04105	COG4608	Belongs to the ABC transporter superfamily
GPY45_RS04110	COG0444	Belongs to the ABC transporter superfamily
GPY45_RS04115	COG0747	negative chemotaxis
GPY45_RS04125	COG4174	ABC transporter (Permease)
GPY45_RS04150	COG0811	peptide transport
GPY45_RS04155	COG0848	biopolymer transport protein
GPY45_RS04170	COG0194	GDP metabolic process
GPY45_RS04175	COG1758	RNA polymerase activity
GPY45_RS04180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY45_RS04185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY45_RS04190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY45_RS04195	COG2233	PERMEase
GPY45_RS04200	COG2205	protein histidine kinase activity
GPY45_RS04205	COG0745	RESPONSE REGULATOR receiver
GPY45_RS04215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY45_RS04225	COG2183	response to ionizing radiation
GPY45_RS04235	COG0596	Alpha beta hydrolase
GPY45_RS04240	COG1040	competence protein
GPY45_RS04245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY45_RS04245	COG0316	Belongs to the HesB IscA family
GPY45_RS04250	COG0494	nUDIX hydrolase
GPY45_RS04255	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY45_RS04265	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY45_RS04270	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY45_RS04275	COG3156	type II secretion system protein K
GPY45_RS04280	COG4795	General secretion pathway protein
GPY45_RS04285	COG2165	general secretion pathway protein
GPY45_RS04290	COG2165	general secretion pathway protein
GPY45_RS04295	COG2165	general secretion pathway protein
GPY45_RS04300	COG1459	type II secretion system
GPY45_RS04305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY45_RS04315	COG3031	protein transport across the cell outer membrane
GPY45_RS04320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY45_RS04325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY45_RS04330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY45_RS04340	COG0456	acetyltransferase
GPY45_RS04345	COG1490	D-aminoacyl-tRNA deacylase activity
GPY45_RS04350	COG1295	ribonuclease BN
GPY45_RS04370	COG0174	glutamine synthetase
GPY45_RS04380	COG3852	Histidine kinase
GPY45_RS04385	COG2204	response regulator
GPY45_RS04395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY45_RS04400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY45_RS04435	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY45_RS04445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY45_RS04445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY45_RS04470	COG0084	hydrolase, TatD family'
GPY45_RS04480	COG0805	protein transport
GPY45_RS04490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY45_RS04495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY45_RS04500	COG3165	ubiquinone biosynthetic process from chorismate
GPY45_RS04505	COG2226	methyltransferase
GPY45_RS04510	COG1322	Protein conserved in bacteria
GPY45_RS04525	COG0628	permease
GPY45_RS04575	COG2823	Periplasmic or secreted lipoprotein
GPY45_RS04585	COG2081	HI0933 family
GPY45_RS04595	COG1528	Iron-storage protein
GPY45_RS04600	COG0589	response to stress
GPY45_RS04605	COG0697	spore germination
GPY45_RS04615	COG0742	ribosomal rna small subunit methyltransferase
GPY45_RS04625	COG1522	sequence-specific DNA binding
GPY45_RS04630	COG0339	signal peptide processing
GPY45_RS04635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY45_RS04640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY45_RS04645	COG0583	DNA-binding transcription factor activity
GPY45_RS04650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY45_RS04655	COG0800	Aldolase
GPY45_RS04660	COG2610	gluconate transmembrane transporter activity
GPY45_RS04665	COG3265	gluconokinase activity
GPY45_RS04670	COG0129	dihydroxy-acid dehydratase activity
GPY45_RS04675	COG2076	Multidrug Resistance protein
GPY45_RS04685	COG0583	DNA-binding transcription factor activity
GPY45_RS04690	COG1609	Transcriptional regulator
GPY45_RS04730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY45_RS04740	COG0747	negative chemotaxis
GPY45_RS04745	COG4172	Belongs to the ABC transporter superfamily
GPY45_RS04810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS04815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY45_RS04825	COG2960	long-chain fatty acid transporting porin activity
GPY45_RS04830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY45_RS04835	COG0583	DNA-binding transcription factor activity
GPY45_RS04875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY45_RS04885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY45_RS04890	COG0408	coproporphyrinogen oxidase activity
GPY45_RS04895	COG0009	L-threonylcarbamoyladenylate synthase
GPY45_RS04900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY45_RS04905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY45_RS04910	COG0551	DNA topoisomerase type I activity
GPY45_RS04915	COG2922	Belongs to the Smg family
GPY45_RS04920	COG0758	DNA mediated transformation
GPY45_RS04930	COG0242	peptide deformylase activity
GPY45_RS04935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY45_RS04940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY45_RS04940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY45_RS04945	COG0569	domain protein
GPY45_RS04950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY45_RS04960	COG1272	protein, Hemolysin III
GPY45_RS04965	COG4326	sporulation control protein
GPY45_RS04975	COG3084	Protein conserved in bacteria
GPY45_RS04985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY45_RS04990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY45_RS04995	COG0204	Acyl-transferase
GPY45_RS05005	COG0606	chelatase, subunit chli
GPY45_RS05015	COG3978	acetolactate synthase activity
GPY45_RS05020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY45_RS05025	COG0129	dihydroxy-acid dehydratase activity
GPY45_RS05035	COG0583	DNA-binding transcription factor activity
GPY45_RS05040	COG2814	Major facilitator Superfamily
GPY45_RS05045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY45_RS05050	COG0765	amino acid transport
GPY45_RS05055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY45_RS05060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY45_RS05065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY45_RS05070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY45_RS05075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY45_RS05080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY45_RS05095	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY45_RS05100	COG3312	ion transport
GPY45_RS05105	COG1475	DNA binding
GPY45_RS05110	COG1192	Involved in chromosome partitioning
GPY45_RS05115	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY45_RS05120	COG0445	tRNA wobble uridine modification
GPY45_RS05125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY45_RS05130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY45_RS05135	COG0706	membrane insertase activity
GPY45_RS05140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY45_RS05145	COG0594	ribonuclease P activity
GPY45_RS05155	COG1126	abc transporter atp-binding protein
GPY45_RS05180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY45_RS05185	COG0592	DNA-directed DNA polymerase activity
GPY45_RS05190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY45_RS05195	COG0187	DNA topoisomerase II activity
GPY45_RS05215	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY45_RS05220	COG3977	Valine--pyruvate aminotransferase
GPY45_RS05225	COG0366	Alpha amylase catalytic
GPY45_RS05230	COG0751	glycine-tRNA ligase activity
GPY45_RS05235	COG0752	glycyl-tRNA synthetase alpha subunit
GPY45_RS05240	COG2119	membrane
GPY45_RS05250	COG0425	Belongs to the sulfur carrier protein TusA family
GPY45_RS05265	COG0604	alcohol dehydrogenase
GPY45_RS05270	COG0183	Belongs to the thiolase family
GPY45_RS05275	COG1024	Enoyl-CoA hydratase
GPY45_RS05275	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY45_RS05285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY45_RS05335	COG3335	DDE superfamily endonuclease
GPY45_RS05345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY45_RS05350	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY45_RS05355	COG0352	thiamine-phosphate diphosphorylase activity
GPY45_RS05360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY45_RS05365	COG2104	thiamine diphosphate biosynthetic process
GPY45_RS05370	COG2022	thiamine diphosphate biosynthetic process
GPY45_RS05380	COG0006	proline dipeptidase activity
GPY45_RS05380	COG0006	proline dipeptidase activity
GPY45_RS05410	COG3220	belongs to the UPF0276 family
GPY45_RS05420	COG0210	DNA helicase
GPY45_RS05430	COG0405	Gamma-glutamyltransferase
GPY45_RS05435	COG1280	lysine exporter protein (LysE YggA)
GPY45_RS05445	COG2962	Rard protein
GPY45_RS05450	COG0514	ATP-dependent DNA helicase (RecQ)
GPY45_RS05465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY45_RS05470	COG0248	Ppx GppA phosphatase
GPY45_RS05475	COG0513	Belongs to the DEAD box helicase family
GPY45_RS05480	COG3118	belongs to the thioredoxin family
GPY45_RS05485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY45_RS05500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY45_RS05505	COG0633	Ferredoxin
GPY45_RS05555	COG3071	HemY protein
GPY45_RS05560	COG2959	enzyme of heme biosynthesis
GPY45_RS05565	COG1587	Uroporphyrinogen-III synthase
GPY45_RS05570	COG0181	hydroxymethylbilane synthase activity
GPY45_RS05575	COG3072	Adenylate cyclase
GPY45_RS05580	COG1965	Belongs to the frataxin family
GPY45_RS05590	COG0019	diaminopimelate decarboxylase activity
GPY45_RS05595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY45_RS05605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY45_RS05610	COG1011	Hydrolase
GPY45_RS05615	COG3287	FIST C domain
GPY45_RS05615	COG2200	EAL domain
GPY45_RS05615	COG2199	diguanylate cyclase activity
GPY45_RS05635	COG0561	phosphatase activity
GPY45_RS05640	COG2267	carboxylic ester hydrolase activity
GPY45_RS05645	COG1280	lysine exporter protein (LysE YggA)
GPY45_RS05650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY45_RS05655	COG0640	Transcriptional regulator
GPY45_RS05660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY45_RS05715	COG2095	MarC family integral membrane protein
GPY45_RS05725	COG0742	ribosomal rna small subunit methyltransferase
GPY45_RS05730	COG0552	protein localization to endoplasmic reticulum
GPY45_RS05735	COG2884	Cell division ATP-binding protein ftsE
GPY45_RS05740	COG2177	Part of the ABC transporter FtsEX involved in
GPY45_RS05750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY45_RS05755	COG0705	Rhomboid family
GPY45_RS05760	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY45_RS05765	COG3161	chorismate lyase activity
GPY45_RS05770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY45_RS05775	COG2937	Belongs to the GPAT DAPAT family
GPY45_RS05785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY45_RS05790	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY45_RS05795	COG0534	Mate efflux family protein
GPY45_RS05800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY45_RS05815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY45_RS05820	COG4206	TonB-dependent receptor
GPY45_RS05830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY45_RS05860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY45_RS05870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY45_RS05905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY45_RS05915	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY45_RS05920	COG0250	Participates in transcription elongation, termination and antitermination
GPY45_RS05925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY45_RS05930	COG0081	regulation of translation
GPY45_RS05935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY45_RS05940	COG0222	ribosome binding
GPY45_RS05945	COG0085	RNA polymerase activity
GPY45_RS05950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY45_RS05955	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY45_RS05960	COG2816	NAD+ diphosphatase activity
GPY45_RS05975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY45_RS05980	COG1573	uracil-dna glycosylase
GPY45_RS05985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY45_RS05990	COG3068	Protein conserved in bacteria
GPY45_RS05995	COG1253	flavin adenine dinucleotide binding
GPY45_RS06010	COG0151	Belongs to the GarS family
GPY45_RS06020	COG0138	bifunctional purine biosynthesis protein purh
GPY45_RS06030	COG0789	Transcriptional regulator
GPY45_RS06035	COG3710	Transcriptional regulator
GPY45_RS06045	COG0531	amino acid
GPY45_RS06050	COG1982	Orn Lys Arg decarboxylase major
GPY45_RS06115	COG3706	GGDEF domain
GPY45_RS06120	COG0488	(ABC) transporter
GPY45_RS06125	COG2814	Major facilitator Superfamily
GPY45_RS06130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY45_RS06135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY45_RS06140	COG2264	protein methyltransferase activity
GPY45_RS06150	COG0439	Biotin carboxylase
GPY45_RS06155	COG0511	ligase activity, forming carbon-carbon bonds
GPY45_RS06160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY45_RS06165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY45_RS06180	COG2814	Major facilitator Superfamily
GPY45_RS06185	COG0784	Response regulator, receiver
GPY45_RS06185	COG2205	protein histidine kinase activity
GPY45_RS06210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY45_RS06220	COG3263	regulation of cellular component size
GPY45_RS06230	COG4232	protein-disulfide reductase activity
GPY45_RS06235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY45_RS06240	COG1027	Aspartate ammonia-lyase
GPY45_RS06245	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY45_RS06250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY45_RS06260	COG2205	protein histidine kinase activity
GPY45_RS06265	COG0745	RESPONSE REGULATOR receiver
GPY45_RS06270	COG3678	ATP-independent chaperone mediated protein folding
GPY45_RS06280	COG0205	6-phosphofructokinase activity
GPY45_RS06285	COG0534	Mate efflux family protein
GPY45_RS06290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY45_RS06295	COG0459	protein refolding
GPY45_RS06310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY45_RS06320	COG1509	lysine 2,3-aminomutase activity
GPY45_RS06325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY45_RS06335	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY45_RS06340	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY45_RS06345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY45_RS06350	COG1053	succinate dehydrogenase
GPY45_RS06380	COG4942	peptidase
GPY45_RS06385	COG1045	serine acetyltransferase
GPY45_RS06390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY45_RS06395	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY45_RS06400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY45_RS06405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY45_RS06420	COG0471	metal ion transport
GPY45_RS06425	COG0688	phosphatidylethanolamine metabolic process
GPY45_RS06430	COG1162	GTPase activity
GPY45_RS06435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY45_RS06505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY45_RS06510	COG0802	atpase or kinase
GPY45_RS06515	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY45_RS06520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY45_RS06525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY45_RS06535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY45_RS06540	COG0330	HflC and HflK could
GPY45_RS06545	COG0330	HflC and HflK could
GPY45_RS06550	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY45_RS06555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY45_RS06565	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY45_RS06570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY45_RS06570	COG1017	nitric oxide dioxygenase activity
GPY45_RS06575	COG1959	2 iron, 2 sulfur cluster binding
GPY45_RS06580	COG0557	exoribonuclease II activity
GPY45_RS06585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY45_RS06590	COG0546	phosphoglycolate phosphatase activity
GPY45_RS06595	COG0180	Tryptophanyl-tRNA synthetase
GPY45_RS06625	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY45_RS06630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY45_RS06640	COG1012	belongs to the aldehyde dehydrogenase family
GPY45_RS06650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY45_RS06655	COG3954	Phosphoribulokinase
GPY45_RS06660	COG3089	Belongs to the UPF0270 family
GPY45_RS06665	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY45_RS06675	COG0488	(ABC) transporter
GPY45_RS06685	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY45_RS06700	COG1047	Peptidyl-prolyl cis-trans
GPY45_RS06710	COG1446	asparaginase
GPY45_RS06715	COG2900	Belongs to the SlyX family
GPY45_RS06725	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY45_RS06730	COG2964	Protein conserved in bacteria
GPY45_RS06735	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY45_RS06740	COG2923	Belongs to the DsrF TusC family
GPY45_RS06755	COG0049	tRNA binding
GPY45_RS06760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY45_RS06765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY45_RS06770	COG2906	2 iron, 2 sulfur cluster binding
GPY45_RS06780	COG0281	malic enzyme
GPY45_RS06790	COG0626	cystathionine gamma-synthase activity
GPY45_RS06795	COG0460	homoserine dehydrogenase
GPY45_RS06795	COG0527	aspartate kinase activity
GPY45_RS06800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY45_RS06810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY45_RS06815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY45_RS06820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY45_RS06825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY45_RS06830	COG0137	argininosuccinate synthase activity
GPY45_RS06835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY45_RS06835	COG0165	Argininosuccinate lyase
GPY45_RS06850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY45_RS06850	COG0678	peroxiredoxin activity
GPY45_RS06860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY45_RS06890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY45_RS06895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY45_RS06905	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY45_RS06910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY45_RS06915	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY45_RS06920	COG2965	DNA replication, synthesis of RNA primer
GPY45_RS06930	COG0359	binds to the 23S rRNA
GPY45_RS06940	COG0305	Participates in initiation and elongation during chromosome replication
GPY45_RS06945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY45_RS06955	COG0432	Pfam Uncharacterised protein family UPF0047
GPY45_RS06960	COG0166	Belongs to the GPI family
GPY45_RS06970	COG0735	belongs to the Fur family
GPY45_RS06980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY45_RS07005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY45_RS07010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY45_RS07015	COG0175	sulfate reduction
GPY45_RS07075	COG3335	DDE superfamily endonuclease
GPY45_RS07095	COG1410	methionine synthase
GPY45_RS07095	COG0646	methionine synthase
GPY45_RS07100	COG0527	aspartate kinase activity
GPY45_RS07105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY45_RS07115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY45_RS07130	COG0629	single-stranded DNA binding
GPY45_RS07135	COG2200	EAL domain
GPY45_RS07135	COG2199	diguanylate cyclase activity
GPY45_RS07160	COG3267	Type II secretory pathway component ExeA
GPY45_RS07160	COG3409	Peptidoglycan-binding domain 1 protein
GPY45_RS07170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY45_RS07175	COG1459	type II secretion system
GPY45_RS07220	COG1077	Cell shape determining protein MreB Mrl
GPY45_RS07225	COG1792	Involved in formation and maintenance of cell shape
GPY45_RS07230	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY45_RS07235	COG0424	maF-like protein
GPY45_RS07240	COG1530	ribonuclease E activity
GPY45_RS07245	COG3164	Protein of unknown function
GPY45_RS07250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY45_RS07255	COG0312	modulator of DNA gyrase
GPY45_RS07260	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY45_RS07265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY45_RS07280	COG0564	pseudouridine synthase activity
GPY45_RS07285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY45_RS07290	COG3028	Belongs to the UPF0307 family
GPY45_RS07295	COG0312	modulator of DNA gyrase
GPY45_RS07300	COG2239	Acts as a magnesium transporter
GPY45_RS07305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY45_RS07310	COG1660	Displays ATPase and GTPase activities
GPY45_RS07315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY45_RS07320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY45_RS07330	COG1137	ATPase activity
GPY45_RS07335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY45_RS07345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY45_RS07345	COG0517	IMP dehydrogenase activity
GPY45_RS07355	COG1127	ABC transporter
GPY45_RS07365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY45_RS07370	COG2854	intermembrane phospholipid transfer
GPY45_RS07380	COG5007	Belongs to the BolA IbaG family
GPY45_RS07385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY45_RS07390	COG0204	Acyl-transferase
GPY45_RS07395	COG0251	oxidation-reduction process
GPY45_RS07400	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY45_RS07405	COG0540	Belongs to the ATCase OTCase family
GPY45_RS07415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY45_RS07420	COG2235	arginine
GPY45_RS07450	COG0525	valine-tRNA ligase activity
GPY45_RS07455	COG2927	DNA polymerase III (CHI subunit)
GPY45_RS07460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY45_RS07465	COG0795	lipopolysaccharide-transporting ATPase activity
GPY45_RS07470	COG0795	lipopolysaccharide-transporting ATPase activity
GPY45_RS07480	COG4325	translation initiation factor activity
GPY45_RS07505	COG1401	restriction endodeoxyribonuclease activity
GPY45_RS07525	COG0726	polysaccharide deacetylase
GPY45_RS07530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY45_RS07535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY45_RS07540	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY45_RS07545	COG1486	melibiose metabolic process
GPY45_RS07550	COG3394	polysaccharide catabolic process
GPY45_RS07560	COG3437	response regulator, receiver
GPY45_RS07610	COG1012	belongs to the aldehyde dehydrogenase family
GPY45_RS07680	COG0741	lytic transglycosylase activity
GPY45_RS07685	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY45_RS07695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY45_RS07705	COG2066	Belongs to the glutaminase family
GPY45_RS07710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY45_RS07715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY45_RS07725	COG1872	DUF167
GPY45_RS07730	COG0762	integral membrane protein
GPY45_RS07735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY45_RS07740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY45_RS07755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY45_RS07760	COG1678	Uncharacterized ACR, COG1678
GPY45_RS07765	COG0189	ligase activity
GPY45_RS07775	COG2356	endonuclease I
GPY45_RS07780	COG3091	SprT-like family
GPY45_RS07790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY45_RS07800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY45_RS07805	COG0583	DNA-binding transcription factor activity
GPY45_RS07810	COG4771	TonB-dependent receptor
GPY45_RS07815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY45_RS07820	COG0126	phosphoglycerate kinase activity
GPY45_RS07825	COG0191	fructose-bisphosphate aldolase activity
GPY45_RS07830	COG0668	transmembrane transport
GPY45_RS07835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY45_RS07845	COG0583	DNA-binding transcription factor activity
GPY45_RS07855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY45_RS07860	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY45_RS07865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY45_RS07875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY45_RS07885	COG3079	Belongs to the UPF0149 family
GPY45_RS07895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY45_RS07910	COG0354	folic acid binding
GPY45_RS07915	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY45_RS07935	COG1595	DNA-templated transcription, initiation
GPY45_RS07940	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY45_RS07950	COG3086	response to oxidative stress
GPY45_RS07955	COG0481	GTPase activity
GPY45_RS07960	COG0681	Belongs to the peptidase S26 family
GPY45_RS07965	COG0571	ribonuclease III activity
GPY45_RS07970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY45_RS07975	COG1381	Involved in DNA repair and RecF pathway recombination
GPY45_RS07980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY45_RS07985	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY45_RS07995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY45_RS08005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY45_RS08010	COG3956	TIGRFAM MazG family protein
GPY45_RS08015	COG0504	CTP synthase activity
GPY45_RS08020	COG0148	phosphopyruvate hydratase activity
GPY45_RS08025	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY45_RS08030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY45_RS08035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY45_RS08040	COG0585	pseudouridine synthase activity
GPY45_RS08045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY45_RS08050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY45_RS08065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY45_RS08070	COG1546	Belongs to the CinA family
GPY45_RS08075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY45_RS08080	COG2137	regulation of response to DNA damage stimulus
GPY45_RS08085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY45_RS08090	COG0527	aspartate kinase activity
GPY45_RS08150	COG3630	sodium ion export across plasma membrane
GPY45_RS08155	COG0511	ligase activity, forming carbon-carbon bonds
GPY45_RS08155	COG5016	pyruvate
GPY45_RS08160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY45_RS08165	COG1063	alcohol dehydrogenase
GPY45_RS08170	COG1238	metal cluster binding
GPY45_RS08175	COG0612	Peptidase, M16
GPY45_RS08180	COG2918	glutathione biosynthetic process
GPY45_RS08190	COG1854	S-ribosylhomocysteine lyase activity
GPY45_RS08195	COG4536	flavin adenine dinucleotide binding
GPY45_RS08200	COG4137	Cytochrome C assembly protein
GPY45_RS08205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY45_RS08210	COG0228	four-way junction DNA binding
GPY45_RS08215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY45_RS08220	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY45_RS08225	COG0335	large ribosomal subunit rRNA binding
GPY45_RS08230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY45_RS08235	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY45_RS08240	COG0237	dephospho-CoA kinase activity
GPY45_RS08250	COG1459	type II secretion system
GPY45_RS08255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY45_RS08260	COG4969	Belongs to the N-Me-Phe pilin family
GPY45_RS08265	COG0157	Belongs to the NadC ModD family
GPY45_RS08275	COG2186	Transcriptional regulator
GPY45_RS08280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY45_RS08285	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY45_RS08290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY45_RS08305	COG0288	reversible hydration of carbon dioxide
GPY45_RS08310	COG0659	secondary active sulfate transmembrane transporter activity
GPY45_RS08320	COG1131	(ABC) transporter
GPY45_RS08325	COG0842	Transport permease protein
GPY45_RS08330	COG1560	Kdo2-lipid A biosynthetic process
GPY45_RS08340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY45_RS08345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY45_RS08350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY45_RS08365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY45_RS08375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY45_RS08380	COG1489	DNA binding
GPY45_RS08385	COG1643	Atp-dependent helicase
GPY45_RS08390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY45_RS08395	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY45_RS08400	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY45_RS08405	COG3112	Uncharacterised protein family (UPF0231)
GPY45_RS08415	COG0004	ammonium transporteR
GPY45_RS08420	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY45_RS08430	COG3842	ATPase activity
GPY45_RS08435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY45_RS08450	COG2971	BadF BadG BcrA BcrD
GPY45_RS08460	COG4608	Belongs to the ABC transporter superfamily
GPY45_RS08465	COG0444	Belongs to the ABC transporter superfamily
GPY45_RS08470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY45_RS08480	COG0747	negative chemotaxis
GPY45_RS08485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY45_RS08485	COG0784	Response regulator, receiver
GPY45_RS08485	COG2198	Histidine kinase
GPY45_RS08485	COG2205	protein histidine kinase activity
GPY45_RS08490	COG2813	Specifically methylates the guanine in position
GPY45_RS08495	COG0628	permease
GPY45_RS08500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY45_RS08505	COG0316	Belongs to the HesB IscA family
GPY45_RS08515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY45_RS08520	COG0739	heme binding
GPY45_RS08525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY45_RS08535	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY45_RS08540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY45_RS08545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY45_RS08550	COG1534	Rna-binding protein
GPY45_RS08555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY45_RS08560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY45_RS08565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY45_RS08570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY45_RS08580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY45_RS08595	COG0779	Required for maturation of 30S ribosomal subunits
GPY45_RS08600	COG0195	Participates in both transcription termination and antitermination
GPY45_RS08605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY45_RS08610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY45_RS08615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY45_RS08620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY45_RS08625	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY45_RS08640	COG0534	Mate efflux family protein
GPY45_RS08665	COG3153	acetyltransferase
GPY45_RS08685	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY45_RS08695	COG0084	hydrolase, TatD family'
GPY45_RS08700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY45_RS08705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY45_RS08710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY45_RS08715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY45_RS08720	COG0813	purine-nucleoside phosphorylase activity
GPY45_RS08730	COG0560	Phosphoserine phosphatase
GPY45_RS08740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY45_RS08745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY45_RS08750	COG0583	DNA-binding transcription factor activity
GPY45_RS08760	COG1022	Amp-dependent synthetase and ligase
GPY45_RS08765	COG2169	Transcriptional regulator
GPY45_RS08790	COG4964	Belongs to the GSP D family
GPY45_RS08850	COG0583	DNA-binding transcription factor activity
GPY45_RS08855	COG0531	amino acid
GPY45_RS08860	COG2731	YhcH YjgK YiaL family protein
GPY45_RS08865	COG3250	beta-galactosidase activity
GPY45_RS08870	COG1609	Transcriptional regulator
GPY45_RS08880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY45_RS08885	COG1085	galactose-1-phosphate uridylyltransferase
GPY45_RS08890	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY45_RS08895	COG2017	converts alpha-aldose to the beta-anomer
GPY45_RS08910	COG2211	Major facilitator Superfamily
GPY45_RS08915	COG1609	Transcriptional regulator
GPY45_RS08920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY45_RS08935	COG0598	Magnesium transport protein CorA
GPY45_RS08940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY45_RS08945	COG1349	DNA-binding transcription factor activity
GPY45_RS08950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY45_RS08955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY45_RS08970	COG2271	Major facilitator Superfamily
GPY45_RS08975	COG0584	glycerophosphoryl diester phosphodiesterase
GPY45_RS08980	COG2171	N-acyltransferase activity
GPY45_RS08985	COG3141	response to X-ray
GPY45_RS09005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY45_RS09010	COG1074	ATP-dependent DNA helicase activity
GPY45_RS09015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY45_RS09025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY45_RS09025	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY45_RS09035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY45_RS09040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY45_RS09045	COG2166	iron-sulfur cluster assembly
GPY45_RS09050	COG3706	GGDEF domain
GPY45_RS09055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY45_RS09060	COG0693	protein deglycase activity
GPY45_RS09065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY45_RS09090	COG1595	DNA-templated transcription, initiation
GPY45_RS09110	COG3056	Lipoprotein
GPY45_RS09115	COG2813	Specifically methylates the guanine in position
GPY45_RS09120	COG0271	Belongs to the BolA IbaG family
GPY45_RS09125	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY45_RS09130	COG1805	sodium ion transport
GPY45_RS09135	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY45_RS09140	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY45_RS09145	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY45_RS09150	COG2871	sodium ion transport
GPY45_RS09155	COG1477	protein flavinylation
GPY45_RS09170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY45_RS09175	COG0514	ATP-dependent DNA helicase (RecQ)
GPY45_RS09180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY45_RS09195	COG0733	neurotransmitter:sodium symporter activity
GPY45_RS09215	COG0442	prolyl-tRNA aminoacylation
GPY45_RS09220	COG1720	tRNA m6t6A37 methyltransferase activity
GPY45_RS09225	COG0254	rRNA binding
GPY45_RS09240	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY45_RS09245	COG1671	Belongs to the UPF0178 family
GPY45_RS09270	COG3098	single-species biofilm formation
GPY45_RS09275	COG0564	pseudouridine synthase activity
GPY45_RS09285	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY45_RS09290	COG0024	Methionine aminopeptidase
GPY45_RS09295	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY45_RS09300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY45_RS09305	COG0528	UMP kinase activity
GPY45_RS09310	COG0233	cytoplasmic translational termination
GPY45_RS09315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY45_RS09320	COG0575	Belongs to the CDS family
GPY45_RS09325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY45_RS09330	COG0750	zinc metalloprotease
GPY45_RS09340	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY45_RS09345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY45_RS09350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY45_RS09355	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY45_RS09360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY45_RS09365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY45_RS09370	COG0587	DNA-directed DNA polymerase activity
GPY45_RS09375	COG0825	malonyl-CoA metabolic process
GPY45_RS09380	COG0037	tRNA processing
GPY45_RS09390	COG0347	Belongs to the P(II) protein family
GPY45_RS09395	COG3021	interspecies interaction between organisms
GPY45_RS09405	COG1388	LysM domain
GPY45_RS09405	COG0741	lytic transglycosylase activity
GPY45_RS09410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY45_RS09415	COG2226	methyltransferase
GPY45_RS09420	COG0328	RNA-DNA hybrid ribonuclease activity
GPY45_RS09425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY45_RS09440	COG1960	acyl-CoA dehydrogenase activity
GPY45_RS09445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY45_RS09450	COG0121	glutamine amidotransferase
GPY45_RS09455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY45_RS09460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY45_RS09465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY45_RS09470	COG2233	PERMEase
GPY45_RS09490	COG1393	Belongs to the ArsC family
GPY45_RS09495	COG4783	chaperone-mediated protein folding
GPY45_RS09510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY45_RS09525	COG2199	diguanylate cyclase activity
GPY45_RS09525	COG2202	Pas domain
GPY45_RS09525	COG2200	EAL domain
GPY45_RS09550	COG3328	transposase activity
GPY45_RS09635	COG4789	Type iii secretion
GPY45_RS09640	COG4792	protein secretion
GPY45_RS09670	COG3710	Transcriptional regulator
GPY45_RS09675	COG3328	transposase activity
GPY45_RS09685	COG4790	Type iii secretion
GPY45_RS09755	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY45_RS09785	COG2207	Transcriptional regulator
GPY45_RS09800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY45_RS09810	COG0747	negative chemotaxis
GPY45_RS09830	COG0804	urea catabolic process
GPY45_RS09920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY45_RS09950	COG2716	regulation of RNA biosynthetic process
GPY45_RS09955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY45_RS09975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY45_RS09980	COG1393	Belongs to the ArsC family
GPY45_RS10010	COG2837	iron assimilation
GPY45_RS10015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS10025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS10030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS10035	COG1334	flagellar protein FlaG
GPY45_RS10040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY45_RS10050	COG1516	flagellar protein fliS
GPY45_RS10060	COG4191	Histidine kinase
GPY45_RS10065	COG2204	response regulator
GPY45_RS10070	COG1677	Flagellar hook-basal body complex protein FliE
GPY45_RS10080	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY45_RS10130	COG1987	bacterial-type flagellum assembly
GPY45_RS10135	COG1684	flagellar biosynthetic protein fliR
GPY45_RS10155	COG0455	bacterial-type flagellum organization
GPY45_RS10170	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY45_RS10175	COG0643	Histidine kinase
GPY45_RS10175	COG2198	Histidine kinase
GPY45_RS10180	COG2201	protein-glutamate methylesterase activity
GPY45_RS10185	COG1192	Involved in chromosome partitioning
GPY45_RS10195	COG0835	chemotaxis
GPY45_RS10205	COG4133	protoheme IX ABC transporter activity
GPY45_RS10210	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY45_RS10215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY45_RS10220	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY45_RS10225	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY45_RS10230	COG1138	Cytochrome C-type biogenesis protein
GPY45_RS10235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY45_RS10250	COG2853	Lipoprotein
GPY45_RS10260	COG2067	long-chain fatty acid transport protein
GPY45_RS10275	COG0183	Belongs to the thiolase family
GPY45_RS10280	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY45_RS10280	COG1024	Enoyl-CoA hydratase
GPY45_RS10295	COG2062	phosphohistidine phosphatase, SixA
GPY45_RS10300	COG2840	Smr protein MutS2
GPY45_RS10305	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY45_RS10310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY45_RS10315	COG2860	membrane
GPY45_RS10325	COG3101	peptidyl-lysine hydroxylation
GPY45_RS10340	COG0431	NADPH-dependent FMN reductase
GPY45_RS10345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY45_RS10345	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY45_RS10350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY45_RS10355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY45_RS10360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY45_RS10370	COG0101	tRNA pseudouridine synthase activity
GPY45_RS10375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY45_RS10380	COG0285	dihydrofolate synthase activity
GPY45_RS10385	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY45_RS10390	COG1286	toxin biosynthetic process
GPY45_RS10395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY45_RS10400	COG0583	DNA-binding transcription factor activity
GPY45_RS10405	COG0745	RESPONSE REGULATOR receiver
GPY45_RS10415	COG2832	Protein of unknown function (DUF454)
GPY45_RS10420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY45_RS10430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY45_RS10435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY45_RS10440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY45_RS10450	COG0251	oxidation-reduction process
GPY45_RS10455	COG3681	Belongs to the UPF0597 family
GPY45_RS10470	COG2261	transglycosylase associated protein
GPY45_RS10475	COG2983	Belongs to the UPF0260 family
GPY45_RS10480	COG0668	transmembrane transport
GPY45_RS10485	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY45_RS10490	COG0346	lactoylglutathione lyase activity
GPY45_RS10500	COG1785	Belongs to the alkaline phosphatase family
GPY45_RS10520	COG2226	methyltransferase
GPY45_RS10535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY45_RS10540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY45_RS10550	COG3139	Protein of unknown function (DUF1315)
GPY45_RS10555	COG0252	asparaginase activity
GPY45_RS10560	COG0616	signal peptide processing
GPY45_RS10565	COG1902	pentaerythritol trinitrate reductase activity
GPY45_RS10565	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY45_RS10570	COG0778	Nitroreductase
GPY45_RS10575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY45_RS10595	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY45_RS10605	COG3083	sulfuric ester hydrolase activity
GPY45_RS10610	COG3082	Protein of unknown function (DUF1414)
GPY45_RS10615	COG3081	Nucleoid-associated protein
GPY45_RS10630	COG1757	Na H antiporter
GPY45_RS10635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY45_RS10640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY45_RS10645	COG2095	MarC family integral membrane protein
GPY45_RS10650	COG1454	alcohol dehydrogenase
GPY45_RS10650	COG1012	belongs to the aldehyde dehydrogenase family
GPY45_RS10670	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY45_RS10680	COG2056	Na+-H+ antiporter family
GPY45_RS10685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY45_RS10700	COG2885	chlorophyll binding
GPY45_RS10710	COG0346	lactoylglutathione lyase activity
GPY45_RS10715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY45_RS10720	COG4660	Part of a membrane complex involved in electron transport
GPY45_RS10725	COG4659	FMN binding
GPY45_RS10730	COG4658	electron transport chain
GPY45_RS10735	COG4656	Part of a membrane complex involved in electron transport
GPY45_RS10740	COG2878	Part of a membrane complex involved in electron transport
GPY45_RS10745	COG4657	Part of a membrane complex involved in electron transport
GPY45_RS10760	COG0556	nucleotide-excision repair
GPY45_RS10765	COG2204	response regulator
GPY45_RS10770	COG2198	Histidine kinase
GPY45_RS10775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY45_RS10780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY45_RS10785	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY45_RS10790	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY45_RS10795	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY45_RS10800	COG0314	molybdopterin synthase activity
GPY45_RS10810	COG0601	transmembrane transport
GPY45_RS10815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY45_RS10820	COG0444	Belongs to the ABC transporter superfamily
GPY45_RS10830	COG0435	Glutathione S-transferase
GPY45_RS10840	COG3174	membrane
GPY45_RS10845	COG0857	belongs to the CobB CobQ family
GPY45_RS10845	COG0280	phosphate acetyltransferase
GPY45_RS10850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY45_RS10855	COG3092	negative regulation of chromosome organization
GPY45_RS10865	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY45_RS10870	COG1122	ATPase activity
GPY45_RS10875	COG0366	Alpha amylase catalytic
GPY45_RS10880	COG3706	GGDEF domain
GPY45_RS10880	COG0745	RESPONSE REGULATOR receiver
GPY45_RS10885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY45_RS10890	COG3318	Belongs to the UPF0149 family
GPY45_RS10890	COG3012	SEC-C Motif Domain Protein
GPY45_RS10895	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY45_RS10900	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY45_RS10905	COG2186	Transcriptional regulator
GPY45_RS10915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY45_RS10915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY45_RS10920	COG0489	protein tyrosine kinase activity
GPY45_RS10925	COG0572	uridine kinase
GPY45_RS10935	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY45_RS10940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY45_RS10945	COG0659	secondary active sulfate transmembrane transporter activity
GPY45_RS10950	COG1530	ribonuclease E activity
GPY45_RS10955	COG0564	pseudouridine synthase activity
GPY45_RS10960	COG0424	maF-like protein
GPY45_RS10965	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY45_RS10975	COG0416	fatty acid biosynthetic process
GPY45_RS10980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY45_RS11010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY45_RS11015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY45_RS11025	COG0084	hydrolase, TatD family'
GPY45_RS11030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY45_RS11030	COG1263	PTS System
GPY45_RS11050	COG0733	neurotransmitter:sodium symporter activity
GPY45_RS11065	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY45_RS11070	COG0469	pyruvate kinase activity
GPY45_RS11075	COG1940	carbohydrate kinase activity
GPY45_RS11080	COG0784	Response regulator, receiver
GPY45_RS11080	COG0835	chemotaxis
GPY45_RS11085	COG0587	DNA-directed DNA polymerase activity
GPY45_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS11105	COG0616	signal peptide processing
GPY45_RS11110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY45_RS11115	COG0539	negative regulation of cytoplasmic translation
GPY45_RS11125	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY45_RS11130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY45_RS11135	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY45_RS11140	COG4166	transmembrane transport
GPY45_RS11165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY45_RS11175	COG3008	intermembrane lipid transfer
GPY45_RS11175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY45_RS11180	COG2995	paraquat-inducible protein a
GPY45_RS11185	COG3258	Cytochrome c
GPY45_RS11190	COG2863	cytochrome
GPY45_RS11230	COG4232	protein-disulfide reductase activity
GPY45_RS11235	COG3118	belongs to the thioredoxin family
GPY45_RS11265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS11275	COG0577	efflux transmembrane transporter activity
GPY45_RS11275	COG1136	(ABC) transporter
GPY45_RS11285	COG0577	efflux transmembrane transporter activity
GPY45_RS11285	COG1136	(ABC) transporter
GPY45_RS11290	COG1335	isochorismatase
GPY45_RS11305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY45_RS11340	COG3850	Histidine kinase
GPY45_RS11340	COG5002	protein histidine kinase activity
GPY45_RS11345	COG0745	RESPONSE REGULATOR receiver
GPY45_RS11355	COG0840	transmembrane signaling receptor activity
GPY45_RS11360	COG1032	radical SAM domain protein
GPY45_RS11365	COG2203	Gaf domain
GPY45_RS11365	COG3706	GGDEF domain
GPY45_RS11365	COG4251	negative regulation of phosphorylation
GPY45_RS11365	COG5001	Diguanylate cyclase
GPY45_RS11380	COG0583	DNA-binding transcription factor activity
GPY45_RS11390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY45_RS11400	COG2350	Protein conserved in bacteria
GPY45_RS11405	COG1607	acyl-coa hydrolase
GPY45_RS11410	COG2917	probably involved in intracellular septation
GPY45_RS11430	COG1301	dicarboxylic acid transport
GPY45_RS11440	COG0318	PFAM AMP-dependent synthetase and ligase
GPY45_RS11445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY45_RS11455	COG0159	tryptophan synthase activity
GPY45_RS11460	COG0133	tryptophan synthase activity
GPY45_RS11465	COG0134	indole-3-glycerol-phosphate synthase activity
GPY45_RS11465	COG0135	phosphoribosylanthranilate isomerase activity
GPY45_RS11470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY45_RS11475	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY45_RS11480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY45_RS11490	COG0613	PHP domain protein
GPY45_RS11495	COG0009	L-threonylcarbamoyladenylate synthase
GPY45_RS11505	COG1187	pseudouridine synthase activity
GPY45_RS11515	COG3099	Belongs to the UPF0263 family
GPY45_RS11520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY45_RS11530	COG0417	DNA replication proofreading
GPY45_RS11535	COG2197	response regulator
GPY45_RS11540	COG0322	excinuclease ABC activity
GPY45_RS11580	COG0019	diaminopimelate decarboxylase activity
GPY45_RS11605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY45_RS11610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY45_RS11615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY45_RS11635	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY45_RS11645	COG0437	4 iron, 4 sulfur cluster binding
GPY45_RS11650	COG3301	Polysulphide reductase, NrfD
GPY45_RS11655	COG1138	Cytochrome C-type biogenesis protein
GPY45_RS11665	COG4235	cytochrome complex assembly
GPY45_RS11665	COG3088	subunit of a heme lyase
GPY45_RS11675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY45_RS11700	COG2989	Protein conserved in bacteria
GPY45_RS11705	COG3108	Peptidase M15
GPY45_RS11710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY45_RS11725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY45_RS11750	COG1846	Transcriptional regulator
GPY45_RS11755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY45_RS11760	COG0840	transmembrane signaling receptor activity
GPY45_RS11780	COG1448	Aminotransferase
GPY45_RS11805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY45_RS11815	COG0017	Asparaginyl-tRNA synthetase
GPY45_RS11825	COG0720	synthase
GPY45_RS11835	COG2200	EAL domain
GPY45_RS11840	COG1760	l-serine dehydratase
GPY45_RS11845	COG0814	amino acid
GPY45_RS11850	COG0494	nUDIX hydrolase
GPY45_RS11860	COG0784	Response regulator, receiver
GPY45_RS11860	COG2205	protein histidine kinase activity
GPY45_RS11865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY45_RS11885	COG3106	COG3106 Predicted ATPase
GPY45_RS11890	COG3768	UPF0283 membrane protein
GPY45_RS11900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY45_RS12035	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GPY45_RS12040	COG2944	sequence-specific DNA binding
GPY45_RS12050	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GPY45_RS12055	COG2944	sequence-specific DNA binding
GPY45_RS12070	COG1247	-acetyltransferase
GPY45_RS12340	COG2827	Endonuclease containing a URI domain
GPY45_RS12390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY45_RS12390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY45_RS12425	COG2026	Addiction module toxin, RelE StbE family
GPY45_RS12515	COG0346	lactoylglutathione lyase activity
GPY45_RS12615	COG0456	acetyltransferase
GPY45_RS12730	COG0346	lactoylglutathione lyase activity
GPY45_RS12840	COG1757	Na H antiporter
GPY45_RS12845	COG0174	glutamine synthetase
GPY45_RS12855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY45_RS12860	COG1917	Cupin 2, conserved barrel domain protein
GPY45_RS12860	COG1396	sequence-specific DNA binding
GPY45_RS12865	COG1012	belongs to the aldehyde dehydrogenase family
GPY45_RS12870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY45_RS12880	COG2957	Belongs to the agmatine deiminase family
GPY45_RS12885	COG1012	belongs to the aldehyde dehydrogenase family
GPY45_RS12890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY45_RS12895	COG1227	inorganic diphosphatase activity
GPY45_RS12905	COG2200	EAL domain
GPY45_RS12905	COG2771	luxR family
GPY45_RS12925	COG1846	Transcriptional regulator
GPY45_RS12950	COG0110	maltose O-acetyltransferase activity
GPY45_RS12980	COG3063	Type IV pilus biogenesis stability protein PilW
GPY45_RS12985	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY45_RS13000	COG0531	amino acid
GPY45_RS13005	COG1560	Kdo2-lipid A biosynthetic process
GPY45_RS13010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY45_RS13015	COG1280	lysine exporter protein (LysE YggA)
GPY45_RS13025	COG1115	amino acid carrier protein
GPY45_RS13055	COG1368	sulfuric ester hydrolase activity
GPY45_RS13060	COG0642	Histidine kinase
GPY45_RS13065	COG0745	RESPONSE REGULATOR receiver
GPY45_RS13075	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS13095	COG2113	Glycine betaine
GPY45_RS13100	COG4176	ABC-type proline glycine betaine transport system permease component
GPY45_RS13120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY45_RS13125	COG0456	acetyltransferase
GPY45_RS13130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY45_RS13135	COG0662	Cupin 2, conserved barrel domain protein
GPY45_RS13140	COG0527	aspartate kinase activity
GPY45_RS13160	COG1858	cytochrome C peroxidase
GPY45_RS13175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS13190	COG3290	protein histidine kinase activity
GPY45_RS13195	COG4565	transcriptional regulatory protein
GPY45_RS13200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY45_RS13205	COG0363	glucosamine-6-phosphate deaminase activity
GPY45_RS13210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY45_RS13230	COG3284	Transcriptional regulator
GPY45_RS13235	COG1012	belongs to the aldehyde dehydrogenase family
GPY45_RS13305	COG4669	(LipO)protein
GPY45_RS13325	COG3177	Filamentation induced by cAMP protein fic
GPY45_RS13375	COG4792	protein secretion
GPY45_RS13380	COG4791	protein targeting
GPY45_RS13385	COG4794	Type iii secretion
GPY45_RS13390	COG4790	Type iii secretion
GPY45_RS13395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY45_RS13460	COG0457	Tetratricopeptide repeat
GPY45_RS13480	COG0730	response to heat
GPY45_RS13510	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY45_RS13515	COG0372	Belongs to the citrate synthase family
GPY45_RS13525	COG2828	Protein conserved in bacteria
GPY45_RS13550	COG0561	phosphatase activity
GPY45_RS13555	COG0602	queuosine metabolic process
GPY45_RS13560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY45_RS13565	COG3706	GGDEF domain
GPY45_RS13605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY45_RS13610	COG0840	transmembrane signaling receptor activity
GPY45_RS13615	COG1254	Belongs to the acylphosphatase family
GPY45_RS13620	COG2920	part of a sulfur-relay system
GPY45_RS13630	COG0670	Belongs to the BI1 family
GPY45_RS13635	COG1126	abc transporter atp-binding protein
GPY45_RS13640	COG0765	amino acid transport
GPY45_RS13645	COG4597	amino acid ABC transporter
GPY45_RS13650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY45_RS13665	COG1666	GTP binding
GPY45_RS13670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY45_RS13690	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY45_RS13690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY45_RS13695	COG3008	intermembrane lipid transfer
GPY45_RS13700	COG2995	paraquat-inducible protein a
GPY45_RS13705	COG1132	(ABC) transporter
GPY45_RS13710	COG1956	GAF domain-containing protein
GPY45_RS13715	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY45_RS13730	COG0308	aminopeptidase N
GPY45_RS13740	COG2902	Dehydrogenase
GPY45_RS13745	COG0167	dihydroorotate dehydrogenase activity
GPY45_RS13760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY45_RS13760	COG0116	Belongs to the methyltransferase superfamily
GPY45_RS13770	COG0488	(ABC) transporter
GPY45_RS13785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY45_RS13790	COG1067	ATP-dependent peptidase activity
GPY45_RS13795	COG3120	sequence-specific DNA binding
GPY45_RS14050	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY45_RS14065	COG2010	Cytochrome c
GPY45_RS14075	COG2217	Heavy metal translocating P-type atpase
GPY45_RS14090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY45_RS14095	COG0589	response to stress
GPY45_RS14105	COG0037	tRNA processing
GPY45_RS14125	COG3842	ATPase activity
GPY45_RS14130	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY45_RS14135	COG1177	transmembrane transport
GPY45_RS14140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY45_RS14145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY45_RS14150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY45_RS14160	COG0004	ammonium transporteR
GPY45_RS14170	COG3209	COG3209 Rhs family protein
GPY45_RS14185	COG0437	4 iron, 4 sulfur cluster binding
GPY45_RS14190	COG3383	formate dehydrogenase (NAD+) activity
GPY45_RS14190	COG0243	molybdopterin cofactor binding
GPY45_RS14200	COG3381	protein complex oligomerization
GPY45_RS14225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY45_RS14230	COG0488	(ABC) transporter
GPY45_RS14240	COG4191	Histidine kinase
GPY45_RS14245	COG2204	response regulator
GPY45_RS14265	COG3842	ATPase activity
GPY45_RS14270	COG0746	molybdenum cofactor guanylyltransferase activity
GPY45_RS14275	COG0303	'Molybdopterin
GPY45_RS14285	COG1940	carbohydrate kinase activity
GPY45_RS14325	COG3290	protein histidine kinase activity
GPY45_RS14325	COG0840	transmembrane signaling receptor activity
GPY45_RS14330	COG0791	NLP P60 protein
GPY45_RS14340	COG3706	GGDEF domain
GPY45_RS14345	COG2201	protein-glutamate methylesterase activity
GPY45_RS14360	COG0307	riboflavin synthase, alpha
GPY45_RS14365	COG0534	Mate efflux family protein
GPY45_RS14375	COG1793	dna ligase
GPY45_RS14410	COG2204	response regulator
GPY45_RS14420	COG0438	transferase activity, transferring glycosyl groups
GPY45_RS14455	COG0438	transferase activity, transferring glycosyl groups
GPY45_RS14460	COG1215	transferase activity, transferring glycosyl groups
GPY45_RS14465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY45_RS14475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY45_RS14490	COG1643	Atp-dependent helicase
GPY45_RS14495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY45_RS14500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY45_RS14500	COG2221	Nitrite and sulphite reductase 4Fe-4S
GPY45_RS14510	COG3302	dmso reductase anchor subunit
GPY45_RS14515	COG0437	4 iron, 4 sulfur cluster binding
GPY45_RS14520	COG0243	molybdopterin cofactor binding
GPY45_RS14550	COG3706	GGDEF domain
GPY45_RS14560	COG0443	Heat shock 70 kDa protein
GPY45_RS14565	COG0443	Heat shock 70 kDa protein
GPY45_RS14595	COG1132	(ABC) transporter
GPY45_RS14600	COG1132	(ABC) transporter
GPY45_RS14625	COG0814	amino acid
GPY45_RS14640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY45_RS14720	COG1522	sequence-specific DNA binding
GPY45_RS14755	COG0515	serine threonine protein kinase
GPY45_RS14780	COG3501	Rhs element vgr protein
GPY45_RS14820	COG0739	heme binding
GPY45_RS14830	COG0861	Integral membrane protein TerC family
GPY45_RS14840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY45_RS14845	COG1328	CTP reductase activity
GPY45_RS14850	COG1280	lysine exporter protein (LysE YggA)
GPY45_RS14860	COG3300	MHYT domain
GPY45_RS14860	COG5001	Diguanylate cyclase
GPY45_RS14870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY45_RS14870	COG4191	Histidine kinase
GPY45_RS14875	COG0471	metal ion transport
GPY45_RS14910	COG0583	DNA-binding transcription factor activity
GPY45_RS14915	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY45_RS15115	COG1783	phage Terminase large subunit
GPY45_RS15160	COG0557	exoribonuclease II activity
GPY45_RS15165	COG1278	Cold shock
GPY45_RS15265	COG0625	glutathione transferase activity
GPY45_RS15275	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY45_RS15285	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY45_RS15295	COG0601	transmembrane transport
GPY45_RS15300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY45_RS15305	COG0444	Belongs to the ABC transporter superfamily
GPY45_RS15325	COG3291	Pkd domain containing protein
GPY45_RS15335	COG1177	transmembrane transport
GPY45_RS15345	COG3842	ATPase activity
GPY45_RS15350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY45_RS15355	COG2423	ornithine cyclodeaminase activity
GPY45_RS15375	COG3938	Belongs to the proline racemase family
GPY45_RS15405	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY45_RS15410	COG1451	nucleotide metabolic process
GPY45_RS15440	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY45_RS15445	COG4139	cobalamin transport
GPY45_RS15450	COG2988	succinylglutamate desuccinylase activity
GPY45_RS15475	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY45_RS15480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY45_RS15485	COG0702	epimerase
GPY45_RS15495	COG2925	Exonuclease
GPY45_RS15500	COG1380	Effector of murein hydrolase LrgA
GPY45_RS15505	COG1346	cytolysis
GPY45_RS15510	COG0295	cytidine deaminase activity
GPY45_RS15515	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY45_RS15520	COG0500	methyltransferase
GPY45_RS15530	COG0776	regulation of translation
GPY45_RS15545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY45_RS15545	COG0072	phenylalanine-tRNA ligase activity
GPY45_RS15550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY45_RS15555	COG3706	GGDEF domain
GPY45_RS15585	COG0393	Putative heavy-metal-binding
GPY45_RS15595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY45_RS15605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY45_RS15620	COG2188	Transcriptional regulator
GPY45_RS15625	COG1228	amidohydrolase
GPY45_RS15630	COG0010	Belongs to the arginase family
GPY45_RS15635	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY45_RS15640	COG2986	histidine ammonia-lyase
GPY45_RS15655	COG0277	FAD linked oxidase domain protein
GPY45_RS15655	COG0247	lactate metabolic process
GPY45_RS15690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY45_RS15705	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY45_RS15710	COG1643	Atp-dependent helicase
GPY45_RS15715	COG0281	malic enzyme
GPY45_RS15720	COG2949	membrane
GPY45_RS15725	COG0471	metal ion transport
GPY45_RS15730	COG3706	GGDEF domain
GPY45_RS15730	COG0745	RESPONSE REGULATOR receiver
GPY45_RS15750	COG0492	ferredoxin-NADP+ reductase activity
GPY45_RS15755	COG4988	ABC transporter
GPY45_RS15760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY45_RS15770	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY45_RS15780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY45_RS15780	COG4191	Histidine kinase
GPY45_RS15795	COG3070	regulator of competence-specific genes
GPY45_RS15810	COG2431	L-lysine efflux transmembrane transporter activity
GPY45_RS15820	COG0076	glutamate decarboxylase activity
GPY45_RS15825	COG1737	Transcriptional regulator
GPY45_RS15840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY45_RS15845	COG2985	domain, Protein
GPY45_RS15845	COG3273	potassium ion transport
GPY45_RS15850	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY45_RS15865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY45_RS15880	COG4181	ATPase activity
GPY45_RS15885	COG0534	Mate efflux family protein
GPY45_RS15890	COG0702	epimerase
GPY45_RS15895	COG3005	denitrification pathway
GPY45_RS15925	COG2814	Major facilitator Superfamily
GPY45_RS15930	COG1187	pseudouridine synthase activity
GPY45_RS15935	COG1061	Type III restriction enzyme res subunit
GPY45_RS15945	COG0745	RESPONSE REGULATOR receiver
GPY45_RS15950	COG2205	protein histidine kinase activity
GPY45_RS15955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY45_RS15985	COG3313	Fe-S protein
GPY45_RS16010	COG0493	'glutamate synthase
GPY45_RS16020	COG0398	Pfam SNARE associated Golgi protein
GPY45_RS16025	COG4134	Bacterial extracellular solute-binding protein
GPY45_RS16030	COG4135	transport system, permease component
GPY45_RS16035	COG4136	ATPase activity
GPY45_RS16040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY45_RS16055	COG3604	Transcriptional regulator
GPY45_RS16060	COG1151	hydroxylamine reductase activity
GPY45_RS16065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY45_RS16075	COG0564	pseudouridine synthase activity
GPY45_RS16085	COG0733	neurotransmitter:sodium symporter activity
GPY45_RS16095	COG0626	cystathionine gamma-synthase activity
GPY45_RS16100	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY45_RS16105	COG5380	lipid catabolic process
GPY45_RS16110	COG2818	Glycosylase
GPY45_RS16125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS16130	COG1983	PspC domain protein
GPY45_RS16140	COG1842	Phage shock protein A
GPY45_RS16145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY45_RS16155	COG4168	peptide transport system, permease
GPY45_RS16160	COG4171	peptide transport system, permease
GPY45_RS16170	COG4172	Belongs to the ABC transporter superfamily
GPY45_RS16180	COG1227	inorganic diphosphatase activity
GPY45_RS16195	COG0243	molybdopterin cofactor binding
GPY45_RS16200	COG3005	denitrification pathway
GPY45_RS16205	COG4459	periplasmic nitrate reductase
GPY45_RS16210	COG0390	transport system, permease component
GPY45_RS16220	COG2116	formate transmembrane transporter activity
GPY45_RS16245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY45_RS16250	COG1435	thymidine kinase activity
GPY45_RS16255	COG0215	cysteine-tRNA ligase activity
GPY45_RS16260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY45_RS16265	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY45_RS16270	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY45_RS16280	COG3012	SEC-C Motif Domain Protein
GPY45_RS16285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY45_RS16285	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY45_RS16290	COG0107	imidazoleglycerol-phosphate synthase activity
GPY45_RS16295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY45_RS16300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY45_RS16305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY45_RS16305	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY45_RS16310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY45_RS16315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY45_RS16320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY45_RS16335	COG1757	Na H antiporter
GPY45_RS16345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY45_RS16355	COG0482	sulfurtransferase activity
GPY45_RS16360	COG2915	High frequency lysogenization protein hflD homolog
GPY45_RS16365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY45_RS16390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY45_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS16415	COG0501	Belongs to the peptidase M48B family
GPY45_RS16425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY45_RS16435	COG0156	8-amino-7-oxononanoate synthase activity
GPY45_RS16440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY45_RS16450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY45_RS16465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY45_RS16470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY45_RS16475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY45_RS16480	COG1674	ftsk spoiiie
GPY45_RS16490	COG0686	Belongs to the AlaDH PNT family
GPY45_RS16500	COG0583	DNA-binding transcription factor activity
GPY45_RS16545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY45_RS16550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS16565	COG0840	transmembrane signaling receptor activity
GPY45_RS16580	COG5002	protein histidine kinase activity
GPY45_RS16580	COG0784	Response regulator, receiver
GPY45_RS16590	COG0754	glutathionylspermidine amidase activity
GPY45_RS16600	COG3766	membrane
GPY45_RS16615	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY45_RS16620	COG2885	chlorophyll binding
GPY45_RS16625	COG0823	Involved in the tonB-independent uptake of proteins
GPY45_RS16640	COG0811	peptide transport
GPY45_RS16645	COG0824	Thioesterase
GPY45_RS16655	COG4890	Cyd operon protein YbgT
GPY45_RS16660	COG1294	oxidase, subunit
GPY45_RS16665	COG1271	oxidase subunit
GPY45_RS16675	COG0632	four-way junction helicase activity
GPY45_RS16680	COG0840	transmembrane signaling receptor activity
GPY45_RS16685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY45_RS16690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY45_RS16695	COG1801	Protein of unknown function DUF72
GPY45_RS16700	COG4106	trans-aconitate 2-methyltransferase activity
GPY45_RS16705	COG0500	methyltransferase
GPY45_RS16715	COG4067	protein conserved in archaea
GPY45_RS16715	COG0189	ligase activity
GPY45_RS16735	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY45_RS16740	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY45_RS16745	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY45_RS16750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY45_RS16755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY45_RS16760	COG0745	RESPONSE REGULATOR receiver
GPY45_RS16765	COG3381	protein complex oligomerization
GPY45_RS16770	COG1609	Transcriptional regulator
GPY45_RS16775	COG3070	regulator of competence-specific genes
GPY45_RS16795	COG0297	glycogen (starch) synthase activity
GPY45_RS16800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY45_RS16805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY45_RS16815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY45_RS16825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY45_RS16830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY45_RS16835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY45_RS16845	COG0542	response to heat
GPY45_RS16850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY45_RS16855	COG1278	Cold shock
GPY45_RS16865	COG1187	pseudouridine synthase activity
GPY45_RS16870	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY45_RS16880	COG1199	ATP-dependent helicase activity
GPY45_RS16885	COG0730	response to heat
GPY45_RS16890	COG3923	Primosomal replication protein n
GPY45_RS16900	COG0708	Exodeoxyribonuclease III
GPY45_RS16915	COG4215	(ABC) transporter
GPY45_RS16945	COG1882	Formate acetyltransferase
GPY45_RS16955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY45_RS16965	COG3013	Belongs to the UPF0304 family
GPY45_RS16975	COG2766	serine protein kinase
GPY45_RS16980	COG2718	Belongs to the UPF0229 family
GPY45_RS16985	COG2719	SpoVR family
GPY45_RS16990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY45_RS17000	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY45_RS17005	COG1132	(ABC) transporter
GPY45_RS17010	COG0658	competence protein
GPY45_RS17010	COG2333	competence protein COMEC
GPY45_RS17020	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY45_RS17025	COG1136	(ABC) transporter
GPY45_RS17030	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY45_RS17040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY45_RS17070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY45_RS17075	COG0573	inorganic phosphate transmembrane transporter activity
GPY45_RS17080	COG0581	inorganic phosphate transmembrane transporter activity
GPY45_RS17085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY45_RS17105	COG2304	oxidoreductase activity
GPY45_RS17125	COG0714	Associated with various cellular activities
GPY45_RS17135	COG0840	transmembrane signaling receptor activity
GPY45_RS17145	COG2197	response regulator
GPY45_RS17195	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY45_RS17200	COG1120	ATPase activity
GPY45_RS17205	COG4774	siderophore transport
GPY45_RS17210	COG1132	(ABC) transporter
GPY45_RS17215	COG5002	protein histidine kinase activity
GPY45_RS17225	COG0569	domain protein
GPY45_RS17230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY45_RS17240	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY45_RS17245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY45_RS17260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY45_RS17260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY45_RS17260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY45_RS17265	COG2207	Transcriptional regulator
GPY45_RS17275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY45_RS17280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY45_RS17285	COG2084	Dehydrogenase
GPY45_RS17290	COG0753	catalase activity
GPY45_RS17300	COG2130	NADP-dependent
GPY45_RS17305	COG1309	transcriptional regulator
GPY45_RS17365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY45_RS17370	COG3842	ATPase activity
GPY45_RS17380	COG1175	transmembrane transport
GPY45_RS17385	COG3833	ABC-type maltose transport systems, permease component
GPY45_RS17405	COG3746	phosphate-selective porin O and P
GPY45_RS17420	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS17435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY45_RS17445	COG0625	glutathione transferase activity
GPY45_RS17455	COG1686	Belongs to the peptidase S11 family
GPY45_RS17480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY45_RS17495	COG1278	Cold shock
GPY45_RS17500	COG1741	Belongs to the pirin family
GPY45_RS17505	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY45_RS17515	COG1846	Transcriptional regulator
GPY45_RS17530	COG2814	Major facilitator Superfamily
GPY45_RS17540	COG0673	inositol 2-dehydrogenase activity
GPY45_RS17545	COG2194	sulfuric ester hydrolase activity
GPY45_RS17550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY45_RS17560	COG2205	protein histidine kinase activity
GPY45_RS17565	COG0745	RESPONSE REGULATOR receiver
GPY45_RS17570	COG4221	oxidoreductase activity
GPY45_RS17590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY45_RS17610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY45_RS17620	COG2814	Major facilitator Superfamily
GPY45_RS17635	COG1418	mRNA catabolic process
GPY45_RS17645	COG0402	S-adenosylhomocysteine deaminase activity
GPY45_RS17650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY45_RS17660	COG2239	Acts as a magnesium transporter
GPY45_RS17665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY45_RS17680	COG0531	amino acid
GPY45_RS17690	COG1522	sequence-specific DNA binding
GPY45_RS17695	COG0583	DNA-binding transcription factor activity
GPY45_RS17720	COG2205	protein histidine kinase activity
GPY45_RS17720	COG5002	protein histidine kinase activity
GPY45_RS17720	COG0784	Response regulator, receiver
GPY45_RS17725	COG0673	inositol 2-dehydrogenase activity
GPY45_RS17730	COG0534	Mate efflux family protein
GPY45_RS17735	COG2926	Belongs to the UPF0265 family
GPY45_RS17750	COG3132	Protein of unknown function, DUF480
GPY45_RS17755	COG2827	Endonuclease containing a URI domain
GPY45_RS17760	COG1879	ABC-type sugar transport system periplasmic component
GPY45_RS17765	COG2205	protein histidine kinase activity
GPY45_RS17765	COG0784	Response regulator, receiver
GPY45_RS17775	COG1566	PFAM secretion protein HlyD family protein
GPY45_RS17795	COG1522	sequence-specific DNA binding
GPY45_RS17820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY45_RS17825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY45_RS17835	COG1280	lysine exporter protein (LysE YggA)
GPY45_RS17845	COG0183	Belongs to the thiolase family
GPY45_RS17865	COG3005	denitrification pathway
GPY45_RS17875	COG0243	molybdopterin cofactor binding
GPY45_RS17885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY45_RS17890	COG3850	Histidine kinase
GPY45_RS17895	COG2197	response regulator
GPY45_RS17910	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY45_RS17930	COG0840	transmembrane signaling receptor activity
GPY45_RS17940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY45_RS17950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY45_RS17955	COG2814	Major facilitator Superfamily
GPY45_RS17965	COG0840	transmembrane signaling receptor activity
GPY45_RS17970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY45_RS17975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY45_RS18000	COG2897	thiosulfate sulfurtransferase activity
GPY45_RS18020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY45_RS18030	COG0302	gtp cyclohydrolase
GPY45_RS18035	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY45_RS18045	COG0038	chloride channel
GPY45_RS18060	COG4989	oxidoreductase activity
GPY45_RS18075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY45_RS18075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY45_RS18080	COG0516	GMP reductase activity
GPY45_RS18085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY45_RS18155	COG3474	cytochrome
GPY45_RS18165	COG0789	Transcriptional regulator
GPY45_RS18170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY45_RS18175	COG0384	phenazine biosynthesis protein PhzF
GPY45_RS18185	COG1294	oxidase, subunit
GPY45_RS18190	COG1271	oxidase subunit
GPY45_RS18195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY45_RS18200	COG0110	maltose O-acetyltransferase activity
GPY45_RS18210	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY45_RS18210	COG3264	Mechanosensitive ion channel
GPY45_RS18225	COG4999	Histidine kinase
GPY45_RS18225	COG3850	Histidine kinase
GPY45_RS18225	COG3437	response regulator, receiver
GPY45_RS18225	COG2205	protein histidine kinase activity
GPY45_RS18245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY45_RS18250	COG1960	acyl-CoA dehydrogenase activity
GPY45_RS18260	COG0183	Belongs to the thiolase family
GPY45_RS18270	COG1960	acyl-CoA dehydrogenase activity
GPY45_RS18275	COG1024	Enoyl-CoA hydratase
GPY45_RS18290	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS18300	COG3706	GGDEF domain
GPY45_RS18305	COG1309	transcriptional regulator
GPY45_RS18310	COG1012	belongs to the aldehyde dehydrogenase family
GPY45_RS18325	COG4176	ABC-type proline glycine betaine transport system permease component
GPY45_RS18330	COG4175	Glycine betaine
GPY45_RS18330	COG0517	IMP dehydrogenase activity
GPY45_RS18345	COG0330	HflC and HflK could
GPY45_RS18355	COG3300	MHYT domain
GPY45_RS18355	COG5001	Diguanylate cyclase
GPY45_RS18375	COG0784	Response regulator, receiver
GPY45_RS18375	COG2205	protein histidine kinase activity
GPY45_RS18435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY45_RS18440	COG5001	Diguanylate cyclase
GPY45_RS18445	COG1869	D-ribose catabolic process
GPY45_RS18450	COG1129	ABC transporter
GPY45_RS18455	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY45_RS18460	COG1879	ABC-type sugar transport system periplasmic component
GPY45_RS18465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY45_RS18470	COG1609	Transcriptional regulator
GPY45_RS18485	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY45_RS18505	COG0745	RESPONSE REGULATOR receiver
GPY45_RS18520	COG1785	Belongs to the alkaline phosphatase family
GPY45_RS18540	COG0745	RESPONSE REGULATOR receiver
GPY45_RS18540	COG3706	GGDEF domain
GPY45_RS18550	COG0814	amino acid
GPY45_RS18555	COG0456	acetyltransferase
GPY45_RS18560	COG0243	molybdopterin cofactor binding
GPY45_RS18565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY45_RS18565	COG1648	precorrin-2 dehydrogenase activity
GPY45_RS18585	COG3707	response regulator
GPY45_RS18595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY45_RS18595	COG1116	anion transmembrane transporter activity
GPY45_RS18600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY45_RS18605	COG1116	anion transmembrane transporter activity
GPY45_RS18610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY45_RS18610	COG2146	nitrite reductase [NAD(P)H] activity
GPY45_RS18665	COG0515	serine threonine protein kinase
GPY45_RS18665	COG2815	serine threonine protein kinase
GPY45_RS18700	COG0631	protein serine/threonine phosphatase activity
GPY45_RS18755	COG3501	Rhs element vgr protein
GPY45_RS18770	COG0420	3'-5' exonuclease activity
GPY45_RS18775	COG0419	ATPase involved in DNA repair
GPY45_RS18795	COG3040	lipid binding
GPY45_RS18805	COG2814	Major facilitator Superfamily
GPY45_RS18815	COG1288	antiporter activity
GPY45_RS18830	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY45_RS18845	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY45_RS18865	COG0583	DNA-binding transcription factor activity
GPY45_RS18870	COG0277	FAD linked oxidase domain protein
GPY45_RS18890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY45_RS18935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY45_RS18935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY45_RS18985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY45_RS18990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY45_RS18995	COG2146	nitrite reductase [NAD(P)H] activity
GPY45_RS19000	COG2116	formate transmembrane transporter activity
GPY45_RS19020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY45_RS19050	COG0534	Mate efflux family protein
GPY45_RS19060	COG2814	Major facilitator Superfamily
GPY45_RS19065	COG3118	belongs to the thioredoxin family
GPY45_RS19070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY45_RS19095	COG2271	Major facilitator Superfamily
GPY45_RS19100	COG3851	Histidine kinase
GPY45_RS19105	COG2197	response regulator
GPY45_RS19115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY45_RS19120	COG0583	DNA-binding transcription factor activity
GPY45_RS19160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY45_RS19175	COG1328	CTP reductase activity
GPY45_RS19180	COG0602	queuosine metabolic process
GPY45_RS19185	COG0534	Mate efflux family protein
GPY45_RS19205	COG4067	protein conserved in archaea
GPY45_RS19205	COG0189	ligase activity
GPY45_RS19215	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY45_RS19220	COG1492	cobalamin metabolic process
GPY45_RS19225	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY45_RS19230	COG4149	molybdate abc transporter
GPY45_RS19235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY45_RS19245	COG2203	Gaf domain
GPY45_RS19245	COG4251	negative regulation of phosphorylation
GPY45_RS19245	COG5001	Diguanylate cyclase
GPY45_RS19245	COG3706	GGDEF domain
GPY45_RS19255	COG0745	RESPONSE REGULATOR receiver
GPY45_RS19255	COG3706	GGDEF domain
GPY45_RS19270	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY45_RS19275	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY45_RS19300	COG3140	Belongs to the UPF0181 family
GPY45_RS19305	COG0589	response to stress
GPY45_RS19400	COG0023	Translation Initiation Factor
GPY45_RS19410	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY45_RS19420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY45_RS19420	COG1042	CoA-binding domain protein
GPY45_RS19420	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY45_RS19425	COG0583	DNA-binding transcription factor activity
GPY45_RS19430	COG4771	TonB-dependent receptor
GPY45_RS19430	COG1629	transport
GPY45_RS19440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY45_RS19445	COG5001	Diguanylate cyclase
GPY45_RS19445	COG5002	protein histidine kinase activity
GPY45_RS19445	COG3447	MASE1 domain protein
GPY45_RS19450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY45_RS19455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY45_RS19460	COG1984	allophanate hydrolase subunit 2
GPY45_RS19470	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY45_RS19475	COG4181	ATPase activity
GPY45_RS19490	COG3300	MHYT domain
GPY45_RS19490	COG5001	Diguanylate cyclase
GPY45_RS19500	COG0484	heat shock protein binding
GPY45_RS19525	COG4533	DNA binding
GPY45_RS19535	COG2050	protein possibly involved in aromatic compounds catabolism
GPY45_RS19550	COG2067	long-chain fatty acid transport protein
GPY45_RS19555	COG2267	carboxylic ester hydrolase activity
GPY45_RS19570	COG0861	Integral membrane protein TerC family
GPY45_RS19575	COG0737	Belongs to the 5'-nucleotidase family
GPY45_RS19580	COG3593	DNA synthesis involved in DNA repair
GPY45_RS19590	COG0583	DNA-binding transcription factor activity
GPY45_RS19595	COG2116	formate transmembrane transporter activity
GPY45_RS19600	COG2353	YceI-like domain
GPY45_RS19605	COG3038	cytochrome b561
GPY45_RS19620	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY45_RS19630	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY45_RS19640	COG0840	transmembrane signaling receptor activity
GPY45_RS19645	COG0546	phosphoglycolate phosphatase activity
GPY45_RS19655	COG3437	response regulator, receiver
GPY45_RS19655	COG0784	Response regulator, receiver
GPY45_RS19675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY45_RS19680	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY45_RS19685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY45_RS19700	COG2207	Transcriptional regulator
GPY45_RS19705	COG1979	alcohol dehydrogenase
GPY45_RS19725	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY45_RS19730	COG2271	Major facilitator Superfamily
GPY45_RS19735	COG0469	pyruvate kinase activity
GPY45_RS19740	COG1126	abc transporter atp-binding protein
GPY45_RS19745	COG0765	amino acid transport
GPY45_RS19750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY45_RS19755	COG0765	amino acid transport
GPY45_RS19760	COG2200	EAL domain
GPY45_RS19760	COG2203	Gaf domain
GPY45_RS19760	COG2199	diguanylate cyclase activity
GPY45_RS19780	COG1609	Transcriptional regulator
GPY45_RS19785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY45_RS19785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY45_RS19790	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY45_RS19795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY45_RS19795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY45_RS19795	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY45_RS19835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY45_RS19840	COG0509	glycine decarboxylation via glycine cleavage system
GPY45_RS19845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY45_RS19845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY45_RS19870	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY45_RS19875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY45_RS19880	COG0583	DNA-binding transcription factor activity
GPY45_RS19885	COG2176	DNA-directed DNA polymerase activity
GPY45_RS19930	COG0242	peptide deformylase activity
GPY45_RS19950	COG2239	Acts as a magnesium transporter
GPY45_RS19970	COG0346	lactoylglutathione lyase activity
GPY45_RS19975	COG1902	pentaerythritol trinitrate reductase activity
GPY45_RS20000	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY45_RS20010	COG0069	glutamate synthase activity
GPY45_RS20010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY45_RS20020	COG4565	transcriptional regulatory protein
GPY45_RS20025	COG3290	protein histidine kinase activity
GPY45_RS20030	COG0471	metal ion transport
GPY45_RS20060	COG2076	Multidrug Resistance protein
GPY45_RS20075	COG0671	phosphoesterase, PA-phosphatase related
GPY45_RS20090	COG2962	Rard protein
GPY45_RS20110	COG0835	chemotaxis
GPY45_RS20110	COG0784	Response regulator, receiver
GPY45_RS20135	COG2197	response regulator
GPY45_RS20145	COG3706	GGDEF domain
GPY45_RS20150	COG2197	response regulator
GPY45_RS20155	COG5001	Diguanylate cyclase
GPY45_RS20155	COG3300	MHYT domain
GPY45_RS20170	COG0583	DNA-binding transcription factor activity
GPY45_RS20175	COG0583	DNA-binding transcription factor activity
GPY45_RS20235	COG4964	Belongs to the GSP D family
GPY45_RS20270	COG4934	collagen metabolic process
GPY45_RS20280	COG0582	viral genome integration into host DNA
GPY45_RS20295	COG0583	DNA-binding transcription factor activity
GPY45_RS20300	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY45_RS20325	COG1278	Cold shock
GPY45_RS20345	COG0330	HflC and HflK could
GPY45_RS20390	COG0641	radical SAM
GPY45_RS20410	COG2003	Belongs to the UPF0758 family
GPY45_RS20445	COG0641	radical SAM
GPY45_RS20460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY45_RS20490	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY45_RS20495	COG1704	LemA family
GPY45_RS20500	COG0501	Belongs to the peptidase M48B family
GPY45_RS20530	COG0641	radical SAM
GPY45_RS20550	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY45_RS20560	COG0583	DNA-binding transcription factor activity
GPY45_RS20565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY45_RS20595	COG0714	Associated with various cellular activities
GPY45_RS20600	COG0641	radical SAM
GPY45_RS20605	COG3119	arylsulfatase activity
GPY45_RS20620	COG3119	arylsulfatase activity
GPY45_RS20625	COG3119	arylsulfatase activity
GPY45_RS20630	COG0745	RESPONSE REGULATOR receiver
GPY45_RS20645	COG2205	protein histidine kinase activity
GPY45_RS20645	COG2198	Histidine kinase
GPY45_RS20645	COG0784	Response regulator, receiver
GPY45_RS20650	COG1879	ABC-type sugar transport system periplasmic component
GPY45_RS20655	COG1803	Methylglyoxal synthase
GPY45_RS20660	COG0210	DNA helicase
GPY45_RS20665	COG1289	transmembrane transporter activity
GPY45_RS20700	COG1629	transport
GPY45_RS20700	COG4771	TonB-dependent receptor
GPY45_RS20715	COG0789	Transcriptional regulator
GPY45_RS20720	COG4604	ABC transporter, ATP-binding protein
GPY45_RS20725	COG4605	iron ion homeostasis
GPY45_RS20735	COG4607	ABC-type enterochelin transport system periplasmic component
GPY45_RS20760	COG2847	Copper chaperone PCu(A)C
GPY45_RS20765	COG0443	Heat shock 70 kDa protein
GPY45_RS20800	COG0625	glutathione transferase activity
GPY45_RS20815	COG4160	amino acid transport
GPY45_RS20820	COG4215	(ABC) transporter
GPY45_RS20825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY45_RS20830	COG1126	abc transporter atp-binding protein
GPY45_RS20840	COG1902	pentaerythritol trinitrate reductase activity
GPY45_RS20855	COG0109	protoheme IX farnesyltransferase activity
GPY45_RS20860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY45_RS20865	COG1845	cytochrome c oxidase, subunit III
GPY45_RS20870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY45_RS20875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY45_RS20880	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS20910	COG0183	Belongs to the thiolase family
GPY45_RS20920	COG1960	acyl-CoA dehydrogenase activity
GPY45_RS20925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY45_RS20930	COG1024	Enoyl-CoA hydratase
GPY45_RS20940	COG5413	integral membrane protein
GPY45_RS20955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY45_RS20965	COG5001	Diguanylate cyclase
GPY45_RS20970	COG0513	Belongs to the DEAD box helicase family
GPY45_RS20975	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY45_RS20990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY45_RS21010	COG0641	radical SAM
GPY45_RS21035	COG0840	transmembrane signaling receptor activity
GPY45_RS21040	COG1119	ATPase activity
GPY45_RS21045	COG2200	EAL domain
GPY45_RS21065	COG0513	Belongs to the DEAD box helicase family
GPY45_RS21070	COG0523	cobalamin synthesis protein
GPY45_RS21080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY45_RS21090	COG0133	tryptophan synthase activity
GPY45_RS21095	COG4628	conserved protein (DUF2132)
GPY45_RS21100	COG0513	Belongs to the DEAD box helicase family
GPY45_RS21105	COG3530	Putative quorum-sensing-regulated virulence factor
GPY45_RS21130	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY45_RS21135	COG3186	Phenylalanine-4-hydroxylase
GPY45_RS21140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY45_RS21145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY45_RS21180	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY45_RS21185	COG1454	alcohol dehydrogenase
GPY45_RS21190	COG2133	pyrroloquinoline quinone binding
GPY45_RS21200	COG0783	Belongs to the Dps family
GPY45_RS21205	COG0840	transmembrane signaling receptor activity
GPY45_RS21215	COG1136	(ABC) transporter
GPY45_RS21215	COG0577	efflux transmembrane transporter activity
GPY45_RS21235	COG2199	diguanylate cyclase activity
GPY45_RS21250	COG3036	rescue of stalled ribosome
GPY45_RS21255	COG1278	Cold shock
GPY45_RS21290	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY45_RS21295	COG0109	protoheme IX farnesyltransferase activity
GPY45_RS21300	COG1612	heme a metabolic process
GPY45_RS21325	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY45_RS21335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY45_RS21340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY45_RS21350	COG1280	lysine exporter protein (LysE YggA)
GPY45_RS21355	COG2207	Transcriptional regulator
GPY45_RS21385	COG0697	spore germination
GPY45_RS21410	COG2814	Major facilitator Superfamily
GPY45_RS21415	COG0583	DNA-binding transcription factor activity
GPY45_RS21420	COG5001	Diguanylate cyclase
GPY45_RS21425	COG0739	heme binding
GPY45_RS21465	COG0814	amino acid
GPY45_RS21485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY45_RS21490	COG1072	(Pantothenic acid kinase))
GPY45_RS21500	COG1063	alcohol dehydrogenase
GPY45_RS21505	COG2213	PTS system mannitol-specific
GPY45_RS21510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY45_RS21530	COG0798	PFAM Bile acid sodium symporter
GPY45_RS21540	COG1881	PFAM PEBP family protein
GPY45_RS21550	COG2706	6-phosphogluconolactonase activity
GPY45_RS21565	COG1131	(ABC) transporter
GPY45_RS21570	COG0842	Transport permease protein
GPY45_RS21585	COG3383	formate dehydrogenase (NAD+) activity
GPY45_RS21630	COG2199	diguanylate cyclase activity
GPY45_RS21630	COG2203	Gaf domain
GPY45_RS21640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY45_RS21650	COG2067	long-chain fatty acid transport protein
GPY45_RS21660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS21670	COG1505	serine-type exopeptidase activity
GPY45_RS21675	COG0488	(ABC) transporter
GPY45_RS21680	COG0589	response to stress
GPY45_RS21685	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY45_RS21705	COG0366	Alpha amylase catalytic
GPY45_RS21715	COG4934	collagen metabolic process
GPY45_RS21730	COG0583	DNA-binding transcription factor activity
GPY45_RS21740	COG0783	Belongs to the Dps family
GPY45_RS21745	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY45_RS21780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY45_RS21790	COG0784	Response regulator, receiver
GPY45_RS21790	COG0835	chemotaxis
GPY45_RS21800	COG0748	coenzyme F420 binding
GPY45_RS21805	COG3721	Heme iron utilization protein
GPY45_RS21815	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY45_RS21820	COG0811	peptide transport
GPY45_RS21825	COG0848	biopolymer transport protein
GPY45_RS21835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY45_RS21840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY45_RS21880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY45_RS21885	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY45_RS21890	COG0633	Ferredoxin
GPY45_RS21890	COG3217	Mosc domain protein beta barrel domain protein
GPY45_RS21890	COG0633	Ferredoxin
GPY45_RS21890	COG3217	Mosc domain protein beta barrel domain protein
GPY45_RS21900	COG0401	homolog of Blt101
GPY45_RS21910	COG0418	dihydroorotase activity
GPY45_RS21915	COG2354	Protein conserved in bacteria
GPY45_RS21945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY45_RS21945	COG2207	Transcriptional regulator
GPY45_RS21950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY45_RS21995	COG0513	Belongs to the DEAD box helicase family
GPY45_RS22005	COG0583	DNA-binding transcription factor activity
GPY45_RS22020	COG1902	pentaerythritol trinitrate reductase activity
GPY45_RS22025	COG1063	alcohol dehydrogenase
GPY45_RS22035	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS22050	COG3122	Protein conserved in bacteria
GPY45_RS22065	COG0583	DNA-binding transcription factor activity
GPY45_RS22075	COG0252	asparaginase activity
GPY45_RS22080	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY45_RS22085	COG0574	Belongs to the PEP-utilizing enzyme family
GPY45_RS22085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY45_RS22105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY45_RS22110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY45_RS22125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS22145	COG3706	GGDEF domain
GPY45_RS22195	COG3842	ATPase activity
GPY45_RS22230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY45_RS22280	COG0583	DNA-binding transcription factor activity
GPY45_RS22290	COG4948	Mandelate Racemase Muconate Lactonizing
GPY45_RS22300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY45_RS22325	COG1342	Belongs to the UPF0251 family
GPY45_RS22335	COG3015	lipoprotein NlpE involved in copper resistance
GPY45_RS22345	COG3713	MltA-interacting MipA family protein
GPY45_RS22360	COG0583	DNA-binding transcription factor activity
GPY45_RS22385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY45_RS22395	COG1335	isochorismatase
GPY45_RS22405	COG0753	catalase activity
GPY45_RS22415	COG1349	DNA-binding transcription factor activity
GPY45_RS22420	COG0346	lactoylglutathione lyase activity
GPY45_RS22425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY45_RS22425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY45_RS22435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY45_RS22440	COG3537	Alpha-1,2-mannosidase
GPY45_RS22445	COG3537	Alpha-1,2-mannosidase
GPY45_RS22455	COG3537	Alpha-1,2-mannosidase
GPY45_RS22460	COG3537	Alpha-1,2-mannosidase
GPY45_RS22465	COG2070	2-Nitropropane dioxygenase
GPY45_RS22470	COG0737	Belongs to the 5'-nucleotidase family
GPY45_RS22480	COG1309	transcriptional regulator
GPY45_RS22500	COG1280	lysine exporter protein (LysE YggA)
GPY45_RS22515	COG0459	protein refolding
GPY45_RS22530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY45_RS22555	COG1304	FMN binding
GPY45_RS22575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS22590	COG1706	bacterial-type flagellum-dependent cell motility
GPY45_RS22595	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY45_RS22600	COG4786	Flagellar basal body rod
GPY45_RS22605	COG4787	bacterial-type flagellum-dependent cell motility
GPY45_RS22610	COG1749	Flagellar hook protein flgE
GPY45_RS22615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY45_RS22620	COG1558	bacterial-type flagellum-dependent cell motility
GPY45_RS22625	COG1815	bacterial-type flagellum-dependent cell motility
GPY45_RS22645	COG0741	lytic transglycosylase activity
GPY45_RS22655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY45_RS22675	COG1760	l-serine dehydratase
GPY45_RS22700	COG0583	DNA-binding transcription factor activity
GPY45_RS22715	COG2866	Carboxypeptidase
GPY45_RS22720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY45_RS22755	COG3842	ATPase activity
GPY45_RS22765	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY45_RS22770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY45_RS22780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY45_RS22785	COG1609	Transcriptional regulator
GPY45_RS22815	COG3240	lipase activity
GPY45_RS22825	COG1136	(ABC) transporter
GPY45_RS22825	COG0577	efflux transmembrane transporter activity
GPY45_RS22830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY45_RS22835	COG2067	long-chain fatty acid transport protein
GPY45_RS22840	COG3338	carbonate dehydratase activity
GPY45_RS22845	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY45_RS22860	COG1011	Hydrolase
GPY45_RS22900	COG0110	maltose O-acetyltransferase activity
GPY45_RS22905	COG1765	OsmC-like protein
GPY45_RS22910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY45_RS22910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY45_RS22925	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY45_RS22930	COG0415	Belongs to the DNA photolyase family
GPY45_RS22935	COG3706	GGDEF domain
GPY45_RS22950	COG0840	transmembrane signaling receptor activity
GPY45_RS22955	COG3706	GGDEF domain
GPY45_RS22960	COG3145	DNA-N1-methyladenine dioxygenase activity
GPY45_RS22970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY45_RS23000	COG0579	oxidoreductase
GPY45_RS23075	COG0583	DNA-binding transcription factor activity
GPY45_RS23085	COG0189	ligase activity
GPY45_RS23090	COG4067	protein conserved in archaea
GPY45_RS23090	COG0189	ligase activity
GPY45_RS23100	COG1166	arginine decarboxylase activity
GPY45_RS23105	COG0010	Belongs to the arginase family
GPY45_RS23110	COG2814	Major facilitator Superfamily
GPY45_RS23115	COG1770	oligopeptidase
GPY45_RS23130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY45_RS23135	COG1121	(ABC) transporter
GPY45_RS23140	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY45_RS23180	COG0848	biopolymer transport protein
GPY45_RS23185	COG0811	peptide transport
GPY45_RS23190	COG0811	peptide transport
GPY45_RS23210	COG0745	RESPONSE REGULATOR receiver
GPY45_RS23220	COG0584	glycerophosphoryl diester phosphodiesterase
GPY45_RS23230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY45_RS23290	COG1901	pseudouridine methyltransferase
GPY45_RS23295	COG0312	modulator of DNA gyrase
GPY45_RS23300	COG0312	modulator of DNA gyrase
GPY45_RS23310	COG0351	phosphomethylpyrimidine kinase
GPY45_RS23315	COG1116	anion transmembrane transporter activity
GPY45_RS23320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY45_RS23325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY45_RS23330	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY45_RS23335	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY45_RS23340	COG0352	thiamine-phosphate diphosphorylase activity
GPY45_RS23350	COG0243	molybdopterin cofactor binding
GPY45_RS23355	COG3005	denitrification pathway
GPY45_RS23365	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS23380	COG0454	-acetyltransferase
GPY45_RS23380	COG0456	acetyltransferase
GPY45_RS23405	COG1929	Belongs to the glycerate kinase type-1 family
GPY45_RS23410	COG2610	gluconate transmembrane transporter activity
GPY45_RS23415	COG3835	regulator
GPY45_RS23440	COG0546	phosphoglycolate phosphatase activity
GPY45_RS23455	COG0583	DNA-binding transcription factor activity
GPY45_RS23465	COG0583	DNA-binding transcription factor activity
GPY45_RS23475	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GPY45_RS23480	COG3408	Glycogen debranching enzyme
GPY45_RS23480	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY45_RS23510	COG3047	cAMP biosynthetic process
GPY45_RS23515	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY45_RS23545	COG2375	cellular response to nickel ion
GPY45_RS23550	COG0823	Involved in the tonB-independent uptake of proteins
GPY45_RS23555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY45_RS23575	COG0800	Aldolase
GPY45_RS23580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY45_RS23595	COG1917	Cupin 2, conserved barrel domain protein
GPY45_RS23605	COG1028	Short-chain dehydrogenase reductase Sdr
GPY45_RS23610	COG1414	Transcriptional regulator
GPY45_RS23625	COG0583	DNA-binding transcription factor activity
GPY45_RS23630	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY45_RS23635	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY45_RS23650	COG2199	diguanylate cyclase activity
GPY45_RS23660	COG0561	phosphatase activity
GPY45_RS23665	COG0583	DNA-binding transcription factor activity
GPY45_RS23680	COG0564	pseudouridine synthase activity
GPY45_RS23685	COG0534	Mate efflux family protein
GPY45_RS23695	COG5001	Diguanylate cyclase
GPY45_RS23705	COG3123	guanosine phosphorylase activity
GPY45_RS23745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY45_RS23750	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY45_RS23765	COG2259	Doxx family
GPY45_RS23770	COG1741	Belongs to the pirin family
GPY45_RS23790	COG0363	glucosamine-6-phosphate deaminase activity
GPY45_RS23805	COG0786	glutamate:sodium symporter activity
GPY45_RS23810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY45_RS23815	COG1131	(ABC) transporter
GPY45_RS23825	COG0786	glutamate:sodium symporter activity
GPY45_RS23860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY45_RS23870	COG3279	Response regulator of the LytR AlgR family
GPY45_RS23875	COG3275	phosphorelay sensor kinase activity
GPY45_RS23895	COG1136	(ABC) transporter
GPY45_RS23910	COG0772	Belongs to the SEDS family
GPY45_RS23915	COG0217	transcriptional regulatory protein
GPY45_RS23940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY45_RS23940	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY45_RS23950	COG0444	Belongs to the ABC transporter superfamily
GPY45_RS23955	COG4608	Belongs to the ABC transporter superfamily
GPY45_RS23980	COG1444	tRNA N-acetyltransferase activity
GPY45_RS24000	COG3340	Belongs to the peptidase S51 family
GPY45_RS24005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY45_RS24010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY45_RS24010	COG1263	PTS System
GPY45_RS24015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY45_RS24035	COG4166	transmembrane transport
GPY45_RS24080	COG0259	pyridoxamine-phosphate oxidase activity
GPY45_RS24110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY45_RS24155	COG1132	(ABC) transporter
GPY45_RS24165	COG2207	Transcriptional regulator
GPY45_RS24185	COG0513	Belongs to the DEAD box helicase family
GPY45_RS24190	COG2258	MOSC domain
GPY45_RS24205	COG1486	melibiose metabolic process
GPY45_RS24210	COG0583	DNA-binding transcription factor activity
GPY45_RS24230	COG1595	DNA-templated transcription, initiation
GPY45_RS24260	COG3634	alkyl hydroperoxide reductase activity
GPY45_RS24265	COG0450	alkyl hydroperoxide reductase
GPY45_RS24270	COG1846	Transcriptional regulator
GPY45_RS24275	COG1764	response to oxidative stress
GPY45_RS24300	COG2160	L-arabinose isomerase activity
GPY45_RS24310	COG1069	ribulokinase activity
GPY45_RS24315	COG1879	ABC-type sugar transport system periplasmic component
GPY45_RS24320	COG1129	ABC transporter
GPY45_RS24325	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY45_RS24350	COG0745	RESPONSE REGULATOR receiver
GPY45_RS24360	COG1653	transport
GPY45_RS24370	COG4264	IucA IucC family
GPY45_RS24395	COG4772	TonB-dependent receptor
GPY45_RS24400	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY45_RS24405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY45_RS24410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY45_RS24415	COG1120	ATPase activity
GPY45_RS24420	COG0840	transmembrane signaling receptor activity
GPY45_RS24425	COG0612	Peptidase, M16
GPY45_RS24435	COG0739	heme binding
GPY45_RS24460	COG4580	involved in the transport of maltose and maltodextrins
GPY45_RS24485	COG2356	endonuclease I
GPY45_RS24505	COG1982	Orn Lys Arg decarboxylase major
GPY45_RS24510	COG0531	amino acid
GPY45_RS24520	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY45_RS24530	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY45_RS24535	COG1162	GTPase activity
GPY45_RS24540	COG1263	PTS System
GPY45_RS24540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY45_RS24550	COG1999	signal sequence binding
GPY45_RS24565	COG2909	trisaccharide binding
GPY45_RS24580	COG0058	SHG alpha-glucan phosphorylase activity
GPY45_RS24585	COG1640	4-alpha-glucanotransferase
GPY45_RS24590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY45_RS24595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY45_RS24600	COG0366	Alpha amylase catalytic
GPY45_RS24615	COG3366	ferrous iron transmembrane transporter activity
GPY45_RS24620	COG0700	Nucleoside recognition
GPY45_RS24625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY45_RS24630	COG3339	Conserved Protein
GPY45_RS24635	COG1301	dicarboxylic acid transport
GPY45_RS24645	COG0583	DNA-binding transcription factor activity
GPY45_RS24660	COG0489	protein tyrosine kinase activity
GPY45_RS24660	COG3206	protein involved in exopolysaccharide biosynthesis
GPY45_RS24680	COG2095	MarC family integral membrane protein
GPY45_RS24685	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY45_RS24690	COG3397	chitin binding
GPY45_RS24710	COG1686	Belongs to the peptidase S11 family
GPY45_RS24735	COG0583	DNA-binding transcription factor activity
GPY45_RS24740	COG4628	conserved protein (DUF2132)
GPY45_RS24750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY45_RS24760	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY45_RS24765	COG0628	permease
GPY45_RS24810	COG2814	Major facilitator Superfamily
GPY45_RS24820	COG0454	-acetyltransferase
GPY45_RS24830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY45_RS24835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY45_RS24890	COG1360	Flagellar Motor Protein
GPY45_RS24895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY45_RS24900	COG1191	sigma factor activity
GPY45_RS24905	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY45_RS24920	COG1516	flagellar protein fliS
GPY45_RS24925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY45_RS24935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY45_RS24960	COG1987	bacterial-type flagellum assembly
GPY45_RS24985	COG2204	response regulator
GPY45_RS25000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY45_RS25040	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY45_RS25060	COG0346	lactoylglutathione lyase activity
GPY45_RS25095	COG0745	RESPONSE REGULATOR receiver
GPY45_RS25115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY45_RS25125	COG0156	8-amino-7-oxononanoate synthase activity
GPY45_RS25130	COG1063	alcohol dehydrogenase
GPY45_RS25170	COG0668	transmembrane transport
GPY45_RS25180	COG1304	FMN binding
GPY45_RS25185	COG1620	l-lactate permease
GPY45_RS25190	COG0583	DNA-binding transcription factor activity
GPY45_RS25195	COG1505	serine-type exopeptidase activity
GPY45_RS25200	COG4172	Belongs to the ABC transporter superfamily
GPY45_RS25210	COG1067	ATP-dependent peptidase activity
GPY45_RS25240	COG1247	-acetyltransferase
GPY45_RS25245	COG0437	4 iron, 4 sulfur cluster binding
GPY45_RS25250	COG0348	domain, Protein
GPY45_RS25265	COG1122	ATPase activity
GPY45_RS25270	COG4720	Psort location CytoplasmicMembrane, score
GPY45_RS25275	COG1566	PFAM secretion protein HlyD family protein
GPY45_RS25285	COG3706	GGDEF domain
GPY45_RS25300	COG0813	purine-nucleoside phosphorylase activity
GPY45_RS25310	COG3272	Protein of unknown function (DUF1722)
GPY45_RS25315	COG0789	Transcriptional regulator
GPY45_RS25320	COG0415	Belongs to the DNA photolyase family
GPY45_RS25325	COG1376	ErfK ybiS ycfS ynhG family protein
GPY45_RS25325	COG1388	LysM domain
GPY45_RS25335	COG0513	Belongs to the DEAD box helicase family
GPY45_RS25340	COG1770	oligopeptidase