locus-tag	class	description
GPY39_RS00010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY39_RS00020	COG2974	May be involved in recombination
GPY39_RS00025	COG0745	RESPONSE REGULATOR receiver
GPY39_RS00030	COG5002	protein histidine kinase activity
GPY39_RS00040	COG0248	Ppx GppA phosphatase
GPY39_RS00045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY39_RS00055	COG0581	inorganic phosphate transmembrane transporter activity
GPY39_RS00060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY39_RS00065	COG0704	Plays a role in the regulation of phosphate uptake
GPY39_RS00075	COG3142	Participates in the control of copper homeostasis
GPY39_RS00080	COG0450	alkyl hydroperoxide reductase
GPY39_RS00085	COG0583	DNA-binding transcription factor activity
GPY39_RS00095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY39_RS00105	COG0517	IMP dehydrogenase activity
GPY39_RS00115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY39_RS00120	COG0343	queuine tRNA-ribosyltransferase activity
GPY39_RS00125	COG1862	Preprotein translocase
GPY39_RS00130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY39_RS00135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY39_RS00145	COG0483	inositol monophosphate 1-phosphatase activity
GPY39_RS00160	COG1104	cysteine desulfurase activity
GPY39_RS00165	COG0822	iron-sulfur transferase activity
GPY39_RS00175	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY39_RS00180	COG0443	Heat shock 70 kDa protein
GPY39_RS00185	COG0633	Ferredoxin
GPY39_RS00190	COG2975	iron-sulfur cluster assembly
GPY39_RS00195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY39_RS00200	COG0105	UTP biosynthetic process
GPY39_RS00205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY39_RS00220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY39_RS00225	COG0124	histidyl-tRNA synthetase
GPY39_RS00230	COG2976	Protein conserved in bacteria
GPY39_RS00235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY39_RS00240	COG1160	GTP binding
GPY39_RS00255	COG1570	exodeoxyribonuclease VII activity
GPY39_RS00260	COG0516	GMP reductase activity
GPY39_RS00260	COG0517	IMP dehydrogenase activity
GPY39_RS00265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY39_RS00265	COG0519	Catalyzes the synthesis of GMP from XMP
GPY39_RS00270	COG1757	Na H antiporter
GPY39_RS00280	COG1584	GPR1 FUN34 yaaH family protein
GPY39_RS00290	COG1115	amino acid carrier protein
GPY39_RS00325	COG2873	o-acetylhomoserine
GPY39_RS00330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY39_RS00350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY39_RS00350	COG3153	acetyltransferase
GPY39_RS00355	COG0583	DNA-binding transcription factor activity
GPY39_RS00405	COG0582	viral genome integration into host DNA
GPY39_RS00415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY39_RS00420	COG2867	negative regulation of translational initiation
GPY39_RS00425	COG2914	Belongs to the UPF0125 (RnfH) family
GPY39_RS00430	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY39_RS00435	COG0497	DNA recombination
GPY39_RS00445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY39_RS00450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY39_RS00460	COG0443	Heat shock 70 kDa protein
GPY39_RS00465	COG0484	heat shock protein binding
GPY39_RS00505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY39_RS00510	COG0590	tRNA wobble adenosine to inosine editing
GPY39_RS00520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY39_RS00525	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY39_RS00525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY39_RS00550	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY39_RS00555	COG2252	PERMEase
GPY39_RS00560	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY39_RS00575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY39_RS00580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY39_RS00585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY39_RS00590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY39_RS00590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY39_RS00610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY39_RS00615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY39_RS00620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY39_RS00625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY39_RS00630	COG0142	geranyltranstransferase activity
GPY39_RS00635	COG1722	exodeoxyribonuclease VII activity
GPY39_RS00640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY39_RS00645	COG2885	chlorophyll binding
GPY39_RS00650	COG0301	tRNA thio-modification
GPY39_RS00650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY39_RS00655	COG0583	DNA-binding transcription factor activity
GPY39_RS00665	COG2363	Small membrane protein
GPY39_RS00670	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GPY39_RS00680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY39_RS00685	COG1611	Belongs to the LOG family
GPY39_RS00690	COG0745	RESPONSE REGULATOR receiver
GPY39_RS00690	COG3706	GGDEF domain
GPY39_RS00700	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY39_RS00700	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY39_RS00710	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY39_RS00715	COG1464	Belongs to the NlpA lipoprotein family
GPY39_RS00720	COG2011	ABC-type metal ion transport system permease component
GPY39_RS00725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY39_RS00735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY39_RS00745	COG1263	PTS System
GPY39_RS00745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY39_RS00750	COG0366	Alpha amylase catalytic
GPY39_RS00765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY39_RS00770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY39_RS00775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY39_RS00780	COG0321	lipoyl(octanoyl) transferase activity
GPY39_RS00785	COG2921	Belongs to the UPF0250 family
GPY39_RS00790	COG1686	Belongs to the peptidase S11 family
GPY39_RS00795	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY39_RS00800	COG0772	Belongs to the SEDS family
GPY39_RS00805	COG0768	penicillin binding
GPY39_RS00810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY39_RS00815	COG0799	negative regulation of ribosome biogenesis
GPY39_RS00820	COG1466	dna polymerase III delta subunit
GPY39_RS00825	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY39_RS00830	COG0495	leucyl-tRNA aminoacylation
GPY39_RS00835	COG2888	peptidyl-tyrosine sulfation
GPY39_RS00840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY39_RS00845	COG4535	Mg2 and Co2 transporter CorC
GPY39_RS00850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY39_RS00855	COG1702	phosphate starvation-inducible protein PhoH
GPY39_RS00860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY39_RS00870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY39_RS00985	COG0012	GTP binding
GPY39_RS00990	COG0193	aminoacyl-tRNA hydrolase activity
GPY39_RS00995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY39_RS01000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY39_RS01005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY39_RS01010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY39_RS01015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY39_RS01020	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY39_RS01025	COG3094	Invasion gene expression up-regulator, SirB
GPY39_RS01030	COG2912	Transglutaminase-like superfamily
GPY39_RS01035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY39_RS01040	COG0737	Belongs to the 5'-nucleotidase family
GPY39_RS01050	COG1187	pseudouridine synthase activity
GPY39_RS01055	COG2840	Smr protein MutS2
GPY39_RS01095	COG2608	mercury ion transmembrane transporter activity
GPY39_RS01095	COG2217	Heavy metal translocating P-type atpase
GPY39_RS01110	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY39_RS01115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY39_RS01175	COG0784	Response regulator, receiver
GPY39_RS01175	COG0835	chemotaxis
GPY39_RS01180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY39_RS01185	COG1815	bacterial-type flagellum-dependent cell motility
GPY39_RS01190	COG1558	bacterial-type flagellum-dependent cell motility
GPY39_RS01195	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY39_RS01200	COG1749	Flagellar hook protein flgE
GPY39_RS01210	COG4787	bacterial-type flagellum-dependent cell motility
GPY39_RS01215	COG4786	Flagellar basal body rod
GPY39_RS01220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY39_RS01225	COG1706	bacterial-type flagellum-dependent cell motility
GPY39_RS01230	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY39_RS01230	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY39_RS01240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS01250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS01260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS01265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS01275	COG2190	(PTS) system
GPY39_RS01280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY39_RS01285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY39_RS01295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY39_RS01300	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY39_RS01305	COG3115	cell septum assembly
GPY39_RS01310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY39_RS01335	COG0330	HflC and HflK could
GPY39_RS01340	COG2194	sulfuric ester hydrolase activity
GPY39_RS01360	COG1215	transferase activity, transferring glycosyl groups
GPY39_RS01365	COG1215	transferase activity, transferring glycosyl groups
GPY39_RS01370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GPY39_RS01375	COG0457	Tetratricopeptide repeat
GPY39_RS01375	COG3118	belongs to the thioredoxin family
GPY39_RS01380	COG3118	belongs to the thioredoxin family
GPY39_RS01390	COG0300	oxidoreductase activity
GPY39_RS01395	COG1090	epimerase
GPY39_RS01425	COG0622	Phosphoesterase
GPY39_RS01445	COG3710	Transcriptional regulator
GPY39_RS01450	COG0326	Molecular chaperone. Has ATPase activity
GPY39_RS01455	COG0563	adenylate kinase activity
GPY39_RS01460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY39_RS01465	COG3104	oligopeptide transport
GPY39_RS01470	COG0250	Participates in transcription elongation, termination and antitermination
GPY39_RS01475	COG0367	asparagine synthase
GPY39_RS01480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY39_RS01480	COG4651	solute:proton antiporter activity
GPY39_RS01485	COG1940	carbohydrate kinase activity
GPY39_RS01485	COG1846	Transcriptional regulator
GPY39_RS01490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY39_RS01500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY39_RS01500	COG2190	(PTS) system
GPY39_RS01500	COG1263	PTS System
GPY39_RS01505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY39_RS01510	COG0735	belongs to the Fur family
GPY39_RS01520	COG0716	FMN binding
GPY39_RS01530	COG0596	Alpha beta hydrolase
GPY39_RS01535	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY39_RS01540	COG0033	Phosphoglucomutase
GPY39_RS01550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY39_RS01560	COG2009	succinate dehydrogenase
GPY39_RS01565	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY39_RS01570	COG1053	succinate dehydrogenase
GPY39_RS01575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY39_RS01580	COG0567	Dehydrogenase, E1 component
GPY39_RS01585	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY39_RS01590	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY39_RS01600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY39_RS01605	COG1121	(ABC) transporter
GPY39_RS01610	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY39_RS01615	COG4977	sequence-specific DNA binding
GPY39_RS01630	COG1918	ferrous iron import across plasma membrane
GPY39_RS01650	COG0018	arginyl-trna synthetase
GPY39_RS01660	COG3102	Protein conserved in bacteria
GPY39_RS01665	COG0788	formyltetrahydrofolate deformylase activity
GPY39_RS01670	COG1199	ATP-dependent helicase activity
GPY39_RS01675	COG1214	PFAM Peptidase M22, glycoprotease
GPY39_RS01690	COG2267	carboxylic ester hydrolase activity
GPY39_RS01695	COG0318	PFAM AMP-dependent synthetase and ligase
GPY39_RS01700	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY39_RS01705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY39_RS01710	COG2894	cell division
GPY39_RS01715	COG0850	regulation of cytokinetic process
GPY39_RS01720	COG3100	YcgL domain-containing protein
GPY39_RS01725	COG2951	lytic endotransglycosylase activity
GPY39_RS01730	COG0583	DNA-binding transcription factor activity
GPY39_RS01735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY39_RS01740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY39_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS01765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY39_RS01770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY39_RS01795	COG2986	histidine ammonia-lyase
GPY39_RS01800	COG1216	Glycosyl transferase, family 2
GPY39_RS01805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY39_RS01820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY39_RS01825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY39_RS01860	COG1253	flavin adenine dinucleotide binding
GPY39_RS01865	COG0513	Belongs to the DEAD box helicase family
GPY39_RS01870	COG0569	domain protein
GPY39_RS01875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY39_RS01895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY39_RS01900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY39_RS01905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY39_RS01910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY39_RS01920	COG2204	response regulator
GPY39_RS01930	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY39_RS01940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY39_RS01945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY39_RS01950	COG0776	regulation of translation
GPY39_RS01955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY39_RS01960	COG1555	photosystem II stabilization
GPY39_RS01975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY39_RS01980	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY39_RS01985	COG0436	Aminotransferase
GPY39_RS01990	COG1169	isochorismate synthase
GPY39_RS01995	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY39_RS02000	COG0596	Alpha beta hydrolase
GPY39_RS02005	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY39_RS02010	COG1441	menaquinone biosynthetic process
GPY39_RS02025	COG2855	membrane
GPY39_RS02030	COG0477	Major facilitator Superfamily
GPY39_RS02075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS02080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY39_RS02110	COG1522	sequence-specific DNA binding
GPY39_RS02120	COG1946	Acyl-CoA thioesterase
GPY39_RS02125	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY39_RS02140	COG2199	diguanylate cyclase activity
GPY39_RS02190	COG0732	type I restriction modification DNA specificity domain
GPY39_RS02215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY39_RS02250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY39_RS02255	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY39_RS02260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY39_RS02270	COG0516	GMP reductase activity
GPY39_RS02270	COG0517	IMP dehydrogenase activity
GPY39_RS02300	COG0537	adenosine 5'-monophosphoramidase activity
GPY39_RS02325	COG3150	esterase
GPY39_RS02335	COG1252	NADH dehydrogenase
GPY39_RS02355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY39_RS02365	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY39_RS02370	COG1136	(ABC) transporter
GPY39_RS02375	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY39_RS02385	COG2333	competence protein COMEC
GPY39_RS02385	COG0658	competence protein
GPY39_RS02390	COG1132	(ABC) transporter
GPY39_RS02395	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY39_RS02405	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY39_RS02410	COG2719	SpoVR family
GPY39_RS02415	COG2718	Belongs to the UPF0229 family
GPY39_RS02420	COG2766	serine protein kinase
GPY39_RS02430	COG3013	Belongs to the UPF0304 family
GPY39_RS02440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY39_RS02450	COG1882	Formate acetyltransferase
GPY39_RS02480	COG4215	(ABC) transporter
GPY39_RS02495	COG0708	Exodeoxyribonuclease III
GPY39_RS02505	COG3923	Primosomal replication protein n
GPY39_RS02510	COG0730	response to heat
GPY39_RS02515	COG1199	ATP-dependent helicase activity
GPY39_RS02520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY39_RS02525	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY39_RS02530	COG1187	pseudouridine synthase activity
GPY39_RS02540	COG1278	Cold shock
GPY39_RS02545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY39_RS02550	COG0542	response to heat
GPY39_RS02560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY39_RS02565	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY39_RS02570	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY39_RS02580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY39_RS02590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY39_RS02595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY39_RS02600	COG0297	glycogen (starch) synthase activity
GPY39_RS02620	COG3070	regulator of competence-specific genes
GPY39_RS02625	COG1609	Transcriptional regulator
GPY39_RS02630	COG3381	protein complex oligomerization
GPY39_RS02635	COG0745	RESPONSE REGULATOR receiver
GPY39_RS02640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY39_RS02645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY39_RS02650	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY39_RS02655	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY39_RS02660	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY39_RS02680	COG4067	protein conserved in archaea
GPY39_RS02680	COG0189	ligase activity
GPY39_RS02690	COG0500	methyltransferase
GPY39_RS02695	COG4106	trans-aconitate 2-methyltransferase activity
GPY39_RS02700	COG1801	Protein of unknown function DUF72
GPY39_RS02705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY39_RS02710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY39_RS02715	COG0840	transmembrane signaling receptor activity
GPY39_RS02720	COG0632	four-way junction helicase activity
GPY39_RS02725	COG2255	four-way junction helicase activity
GPY39_RS02730	COG1271	oxidase subunit
GPY39_RS02735	COG1294	oxidase, subunit
GPY39_RS02740	COG4890	Cyd operon protein YbgT
GPY39_RS02750	COG0824	Thioesterase
GPY39_RS02755	COG0811	peptide transport
GPY39_RS02770	COG0823	Involved in the tonB-independent uptake of proteins
GPY39_RS02775	COG2885	chlorophyll binding
GPY39_RS02780	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY39_RS02785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY39_RS02795	COG3766	membrane
GPY39_RS02805	COG0754	glutathionylspermidine amidase activity
GPY39_RS02815	COG5002	protein histidine kinase activity
GPY39_RS02815	COG0784	Response regulator, receiver
GPY39_RS02830	COG0840	transmembrane signaling receptor activity
GPY39_RS02845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS02850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY39_RS02880	COG3568	Endonuclease Exonuclease Phosphatase
GPY39_RS02895	COG0583	DNA-binding transcription factor activity
GPY39_RS02905	COG0686	Belongs to the AlaDH PNT family
GPY39_RS02915	COG1674	ftsk spoiiie
GPY39_RS02920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY39_RS02925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY39_RS02930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY39_RS02945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY39_RS02950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY39_RS02955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY39_RS02960	COG0156	8-amino-7-oxononanoate synthase activity
GPY39_RS02970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY39_RS02980	COG0501	Belongs to the peptidase M48B family
GPY39_RS02990	COG0300	oxidoreductase activity
GPY39_RS03005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY39_RS03030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY39_RS03035	COG2915	High frequency lysogenization protein hflD homolog
GPY39_RS03040	COG0482	sulfurtransferase activity
GPY39_RS03050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY39_RS03060	COG1757	Na H antiporter
GPY39_RS03075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY39_RS03080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY39_RS03085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY39_RS03090	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY39_RS03090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY39_RS03095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY39_RS03100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY39_RS03105	COG0107	imidazoleglycerol-phosphate synthase activity
GPY39_RS03110	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY39_RS03110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY39_RS03115	COG3012	SEC-C Motif Domain Protein
GPY39_RS03125	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY39_RS03130	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY39_RS03135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY39_RS03140	COG0215	cysteine-tRNA ligase activity
GPY39_RS03145	COG1435	thymidine kinase activity
GPY39_RS03150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY39_RS03175	COG2116	formate transmembrane transporter activity
GPY39_RS03185	COG0390	transport system, permease component
GPY39_RS03190	COG4459	periplasmic nitrate reductase
GPY39_RS03195	COG3005	denitrification pathway
GPY39_RS03200	COG0243	molybdopterin cofactor binding
GPY39_RS03215	COG1227	inorganic diphosphatase activity
GPY39_RS03225	COG4172	Belongs to the ABC transporter superfamily
GPY39_RS03235	COG4171	peptide transport system, permease
GPY39_RS03240	COG4168	peptide transport system, permease
GPY39_RS03250	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY39_RS03255	COG1842	Phage shock protein A
GPY39_RS03265	COG1983	PspC domain protein
GPY39_RS03270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS03285	COG2818	Glycosylase
GPY39_RS03290	COG5380	lipid catabolic process
GPY39_RS03295	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY39_RS03300	COG0626	cystathionine gamma-synthase activity
GPY39_RS03310	COG0733	neurotransmitter:sodium symporter activity
GPY39_RS03320	COG0564	pseudouridine synthase activity
GPY39_RS03330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY39_RS03335	COG1151	hydroxylamine reductase activity
GPY39_RS03340	COG3604	Transcriptional regulator
GPY39_RS03355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY39_RS03360	COG4136	ATPase activity
GPY39_RS03365	COG4135	transport system, permease component
GPY39_RS03370	COG4134	Bacterial extracellular solute-binding protein
GPY39_RS03375	COG0398	Pfam SNARE associated Golgi protein
GPY39_RS03385	COG0493	'glutamate synthase
GPY39_RS03410	COG3313	Fe-S protein
GPY39_RS03440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY39_RS03445	COG2205	protein histidine kinase activity
GPY39_RS03450	COG0745	RESPONSE REGULATOR receiver
GPY39_RS03460	COG1061	Type III restriction enzyme res subunit
GPY39_RS03465	COG1187	pseudouridine synthase activity
GPY39_RS03470	COG2814	Major facilitator Superfamily
GPY39_RS03500	COG3005	denitrification pathway
GPY39_RS03505	COG0702	epimerase
GPY39_RS03510	COG0534	Mate efflux family protein
GPY39_RS03515	COG1136	(ABC) transporter
GPY39_RS03530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY39_RS03545	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY39_RS03555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY39_RS03570	COG1737	Transcriptional regulator
GPY39_RS03575	COG0076	glutamate decarboxylase activity
GPY39_RS03585	COG2431	L-lysine efflux transmembrane transporter activity
GPY39_RS03600	COG3070	regulator of competence-specific genes
GPY39_RS03615	COG4191	Histidine kinase
GPY39_RS03615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY39_RS03625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY39_RS03630	COG3048	D-serine ammonia-lyase activity
GPY39_RS03635	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY39_RS03640	COG4988	ABC transporter
GPY39_RS03645	COG0492	ferredoxin-NADP+ reductase activity
GPY39_RS03665	COG3706	GGDEF domain
GPY39_RS03665	COG0745	RESPONSE REGULATOR receiver
GPY39_RS03670	COG0471	metal ion transport
GPY39_RS03675	COG2949	membrane
GPY39_RS03680	COG0281	malic enzyme
GPY39_RS03685	COG1643	Atp-dependent helicase
GPY39_RS03690	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY39_RS03705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY39_RS03740	COG0277	FAD linked oxidase domain protein
GPY39_RS03740	COG0247	lactate metabolic process
GPY39_RS03755	COG2986	histidine ammonia-lyase
GPY39_RS03760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY39_RS03765	COG0010	Belongs to the arginase family
GPY39_RS03770	COG1228	amidohydrolase
GPY39_RS03775	COG2188	Transcriptional regulator
GPY39_RS03790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY39_RS03800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY39_RS03810	COG0393	Putative heavy-metal-binding
GPY39_RS03840	COG3706	GGDEF domain
GPY39_RS03845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY39_RS03850	COG0072	phenylalanine-tRNA ligase activity
GPY39_RS03850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY39_RS03865	COG0776	regulation of translation
GPY39_RS03875	COG0500	methyltransferase
GPY39_RS03880	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY39_RS03885	COG0295	cytidine deaminase activity
GPY39_RS03890	COG1346	cytolysis
GPY39_RS03895	COG1380	Effector of murein hydrolase LrgA
GPY39_RS03900	COG2925	Exonuclease
GPY39_RS03910	COG0702	epimerase
GPY39_RS03915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY39_RS03920	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY39_RS03930	COG2062	phosphohistidine phosphatase, SixA
GPY39_RS03945	COG2988	succinylglutamate desuccinylase activity
GPY39_RS03950	COG4139	cobalamin transport
GPY39_RS03955	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY39_RS03975	COG0583	DNA-binding transcription factor activity
GPY39_RS03985	COG1451	nucleotide metabolic process
GPY39_RS03990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY39_RS04020	COG3938	Belongs to the proline racemase family
GPY39_RS04040	COG2423	ornithine cyclodeaminase activity
GPY39_RS04045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY39_RS04050	COG3842	ATPase activity
GPY39_RS04055	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY39_RS04060	COG1177	transmembrane transport
GPY39_RS04070	COG3291	Pkd domain containing protein
GPY39_RS04090	COG0444	Belongs to the ABC transporter superfamily
GPY39_RS04095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY39_RS04100	COG0601	transmembrane transport
GPY39_RS04110	COG0813	purine-nucleoside phosphorylase activity
GPY39_RS04130	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY39_RS04145	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY39_RS04155	COG0625	glutathione transferase activity
GPY39_RS04255	COG1278	Cold shock
GPY39_RS04260	COG0557	exoribonuclease II activity
GPY39_RS04300	COG1475	DNA binding
GPY39_RS04310	COG1783	phage Terminase large subunit
GPY39_RS04445	COG1566	PFAM secretion protein HlyD family protein
GPY39_RS04510	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS04535	COG1757	Na H antiporter
GPY39_RS04540	COG0174	glutamine synthetase
GPY39_RS04550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY39_RS04555	COG1917	Cupin 2, conserved barrel domain protein
GPY39_RS04555	COG1396	sequence-specific DNA binding
GPY39_RS04560	COG1012	belongs to the aldehyde dehydrogenase family
GPY39_RS04565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY39_RS04575	COG2957	Belongs to the agmatine deiminase family
GPY39_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
GPY39_RS04585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY39_RS04590	COG1227	inorganic diphosphatase activity
GPY39_RS04600	COG2771	luxR family
GPY39_RS04600	COG2200	EAL domain
GPY39_RS04610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY39_RS04625	COG1846	Transcriptional regulator
GPY39_RS04630	COG2315	Protein conserved in bacteria
GPY39_RS04650	COG0110	maltose O-acetyltransferase activity
GPY39_RS04680	COG3063	Type IV pilus biogenesis stability protein PilW
GPY39_RS04685	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY39_RS04700	COG0531	amino acid
GPY39_RS04710	COG1560	Kdo2-lipid A biosynthetic process
GPY39_RS04715	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY39_RS04720	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS04730	COG1115	amino acid carrier protein
GPY39_RS04755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY39_RS04770	COG0814	amino acid
GPY39_RS04795	COG1132	(ABC) transporter
GPY39_RS04800	COG1132	(ABC) transporter
GPY39_RS04830	COG0443	Heat shock 70 kDa protein
GPY39_RS04835	COG0443	Heat shock 70 kDa protein
GPY39_RS04845	COG3706	GGDEF domain
GPY39_RS04875	COG0243	molybdopterin cofactor binding
GPY39_RS04880	COG0437	4 iron, 4 sulfur cluster binding
GPY39_RS04885	COG3302	dmso reductase anchor subunit
GPY39_RS04900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY39_RS04905	COG1643	Atp-dependent helicase
GPY39_RS04920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY39_RS04930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY39_RS04935	COG1215	transferase activity, transferring glycosyl groups
GPY39_RS04940	COG0438	transferase activity, transferring glycosyl groups
GPY39_RS04985	COG2204	response regulator
GPY39_RS05020	COG1793	dna ligase
GPY39_RS05030	COG0534	Mate efflux family protein
GPY39_RS05035	COG0307	riboflavin synthase, alpha
GPY39_RS05050	COG2201	protein-glutamate methylesterase activity
GPY39_RS05055	COG3706	GGDEF domain
GPY39_RS05065	COG0791	NLP P60 protein
GPY39_RS05110	COG1940	carbohydrate kinase activity
GPY39_RS05120	COG0303	'Molybdopterin
GPY39_RS05125	COG0746	molybdenum cofactor guanylyltransferase activity
GPY39_RS05130	COG3842	ATPase activity
GPY39_RS05150	COG2204	response regulator
GPY39_RS05155	COG4191	Histidine kinase
GPY39_RS05165	COG0488	(ABC) transporter
GPY39_RS05170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY39_RS05195	COG3381	protein complex oligomerization
GPY39_RS05205	COG3383	formate dehydrogenase (NAD+) activity
GPY39_RS05205	COG0243	molybdopterin cofactor binding
GPY39_RS05210	COG0437	4 iron, 4 sulfur cluster binding
GPY39_RS05235	COG0004	ammonium transporteR
GPY39_RS05245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY39_RS05250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY39_RS05255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY39_RS05260	COG1177	transmembrane transport
GPY39_RS05265	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY39_RS05270	COG3842	ATPase activity
GPY39_RS05290	COG0037	tRNA processing
GPY39_RS05300	COG0589	response to stress
GPY39_RS05305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY39_RS05320	COG2217	Heavy metal translocating P-type atpase
GPY39_RS05330	COG2010	Cytochrome c
GPY39_RS05345	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY39_RS05540	COG3120	sequence-specific DNA binding
GPY39_RS05545	COG1067	ATP-dependent peptidase activity
GPY39_RS05550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY39_RS05575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY39_RS05575	COG0116	Belongs to the methyltransferase superfamily
GPY39_RS05590	COG0167	dihydroorotate dehydrogenase activity
GPY39_RS05595	COG2902	Dehydrogenase
GPY39_RS05605	COG0308	aminopeptidase N
GPY39_RS05620	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY39_RS05625	COG1956	GAF domain-containing protein
GPY39_RS05630	COG1132	(ABC) transporter
GPY39_RS05635	COG2995	paraquat-inducible protein a
GPY39_RS05640	COG3008	intermembrane lipid transfer
GPY39_RS05645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY39_RS05645	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY39_RS05665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY39_RS05670	COG1666	GTP binding
GPY39_RS05685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY39_RS05690	COG4597	amino acid ABC transporter
GPY39_RS05695	COG0765	amino acid transport
GPY39_RS05700	COG1126	abc transporter atp-binding protein
GPY39_RS05705	COG0670	Belongs to the BI1 family
GPY39_RS05715	COG2920	part of a sulfur-relay system
GPY39_RS05720	COG1254	Belongs to the acylphosphatase family
GPY39_RS05725	COG0840	transmembrane signaling receptor activity
GPY39_RS05730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY39_RS05775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY39_RS05780	COG0602	queuosine metabolic process
GPY39_RS05785	COG0561	phosphatase activity
GPY39_RS05800	COG0456	acetyltransferase
GPY39_RS05810	COG2828	Protein conserved in bacteria
GPY39_RS05820	COG0372	Belongs to the citrate synthase family
GPY39_RS05825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY39_RS05855	COG0730	response to heat
GPY39_RS05875	COG0457	Tetratricopeptide repeat
GPY39_RS05940	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY39_RS05945	COG4790	Type iii secretion
GPY39_RS05950	COG4794	Type iii secretion
GPY39_RS05955	COG4791	protein targeting
GPY39_RS05960	COG4792	protein secretion
GPY39_RS05970	COG1073	alpha beta
GPY39_RS05975	COG1073	alpha beta
GPY39_RS06015	COG3177	Filamentation induced by cAMP protein fic
GPY39_RS06035	COG4669	(LipO)protein
GPY39_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
GPY39_RS06110	COG3284	Transcriptional regulator
GPY39_RS06130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY39_RS06135	COG0363	glucosamine-6-phosphate deaminase activity
GPY39_RS06140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY39_RS06145	COG4565	transcriptional regulatory protein
GPY39_RS06150	COG3290	protein histidine kinase activity
GPY39_RS06165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS06180	COG1858	cytochrome C peroxidase
GPY39_RS06185	COG0527	aspartate kinase activity
GPY39_RS06190	COG0662	Cupin 2, conserved barrel domain protein
GPY39_RS06195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY39_RS06200	COG0456	acetyltransferase
GPY39_RS06205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY39_RS06220	COG4175	Glycine betaine
GPY39_RS06225	COG4176	ABC-type proline glycine betaine transport system permease component
GPY39_RS06230	COG2113	Glycine betaine
GPY39_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS06260	COG0745	RESPONSE REGULATOR receiver
GPY39_RS06265	COG0642	Histidine kinase
GPY39_RS06270	COG1368	sulfuric ester hydrolase activity
GPY39_RS06280	COG0861	Integral membrane protein TerC family
GPY39_RS06290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY39_RS06295	COG1328	CTP reductase activity
GPY39_RS06300	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS06310	COG5001	Diguanylate cyclase
GPY39_RS06310	COG3300	MHYT domain
GPY39_RS06320	COG4191	Histidine kinase
GPY39_RS06320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY39_RS06325	COG0471	metal ion transport
GPY39_RS06360	COG0583	DNA-binding transcription factor activity
GPY39_RS06435	COG3422	double-strand break repair
GPY39_RS06465	COG0582	viral genome integration into host DNA
GPY39_RS06500	COG1714	RDD family
GPY39_RS06820	COG0653	protein targeting
GPY39_RS06830	COG0456	acetyltransferase
GPY39_RS06830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPY39_RS07040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY39_RS07040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY39_RS07085	COG0456	acetyltransferase
GPY39_RS07125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPY39_RS07190	COG0346	lactoylglutathione lyase activity
GPY39_RS07315	COG0346	lactoylglutathione lyase activity
GPY39_RS07385	COG1335	isochorismatase
GPY39_RS07500	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS07515	COG0251	oxidation-reduction process
GPY39_RS07620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY39_RS07630	COG3768	UPF0283 membrane protein
GPY39_RS07635	COG3106	COG3106 Predicted ATPase
GPY39_RS07655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY39_RS07660	COG2205	protein histidine kinase activity
GPY39_RS07660	COG0784	Response regulator, receiver
GPY39_RS07670	COG0494	nUDIX hydrolase
GPY39_RS07675	COG0814	amino acid
GPY39_RS07680	COG1760	l-serine dehydratase
GPY39_RS07685	COG2200	EAL domain
GPY39_RS07695	COG0720	synthase
GPY39_RS07700	COG3646	Phage regulatory protein
GPY39_RS07725	COG3646	Phage regulatory protein
GPY39_RS07940	COG0751	glycine-tRNA ligase activity
GPY39_RS07975	COG5532	Uncharacterized conserved protein (DUF2303)
GPY39_RS07995	COG1278	Cold shock
GPY39_RS08000	COG0582	viral genome integration into host DNA
GPY39_RS08005	COG0840	transmembrane signaling receptor activity
GPY39_RS08010	COG0017	Asparaginyl-tRNA synthetase
GPY39_RS08020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY39_RS08045	COG1448	Aminotransferase
GPY39_RS08065	COG0840	transmembrane signaling receptor activity
GPY39_RS08070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY39_RS08075	COG1846	Transcriptional regulator
GPY39_RS08100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY39_RS08115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY39_RS08120	COG3108	Peptidase M15
GPY39_RS08125	COG2989	Protein conserved in bacteria
GPY39_RS08150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY39_RS08160	COG4235	cytochrome complex assembly
GPY39_RS08160	COG3088	subunit of a heme lyase
GPY39_RS08170	COG1138	Cytochrome C-type biogenesis protein
GPY39_RS08175	COG3301	Polysulphide reductase, NrfD
GPY39_RS08180	COG0437	4 iron, 4 sulfur cluster binding
GPY39_RS08190	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY39_RS08210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY39_RS08215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY39_RS08220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY39_RS08245	COG0019	diaminopimelate decarboxylase activity
GPY39_RS08285	COG0322	excinuclease ABC activity
GPY39_RS08290	COG2197	response regulator
GPY39_RS08295	COG0417	DNA replication proofreading
GPY39_RS08305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY39_RS08310	COG3099	Belongs to the UPF0263 family
GPY39_RS08320	COG1187	pseudouridine synthase activity
GPY39_RS08330	COG0009	L-threonylcarbamoyladenylate synthase
GPY39_RS08335	COG0613	PHP domain protein
GPY39_RS08345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY39_RS08350	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY39_RS08355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY39_RS08360	COG0135	phosphoribosylanthranilate isomerase activity
GPY39_RS08360	COG0134	indole-3-glycerol-phosphate synthase activity
GPY39_RS08365	COG0133	tryptophan synthase activity
GPY39_RS08370	COG0159	tryptophan synthase activity
GPY39_RS08380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY39_RS08385	COG0318	PFAM AMP-dependent synthetase and ligase
GPY39_RS08395	COG1301	dicarboxylic acid transport
GPY39_RS08415	COG2917	probably involved in intracellular septation
GPY39_RS08420	COG1607	acyl-coa hydrolase
GPY39_RS08425	COG2350	Protein conserved in bacteria
GPY39_RS08435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY39_RS08445	COG0583	DNA-binding transcription factor activity
GPY39_RS08460	COG2203	Gaf domain
GPY39_RS08460	COG5001	Diguanylate cyclase
GPY39_RS08460	COG4251	negative regulation of phosphorylation
GPY39_RS08460	COG3706	GGDEF domain
GPY39_RS08465	COG1032	radical SAM domain protein
GPY39_RS08470	COG0840	transmembrane signaling receptor activity
GPY39_RS08480	COG0745	RESPONSE REGULATOR receiver
GPY39_RS08485	COG3850	Histidine kinase
GPY39_RS08485	COG5002	protein histidine kinase activity
GPY39_RS08520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY39_RS08535	COG1335	isochorismatase
GPY39_RS08540	COG1136	(ABC) transporter
GPY39_RS08540	COG0577	efflux transmembrane transporter activity
GPY39_RS08550	COG1136	(ABC) transporter
GPY39_RS08550	COG0577	efflux transmembrane transporter activity
GPY39_RS08560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS08590	COG3118	belongs to the thioredoxin family
GPY39_RS08595	COG4232	protein-disulfide reductase activity
GPY39_RS08635	COG2863	cytochrome
GPY39_RS08640	COG3258	Cytochrome c
GPY39_RS08645	COG2995	paraquat-inducible protein a
GPY39_RS08650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY39_RS08650	COG3008	intermembrane lipid transfer
GPY39_RS08660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY39_RS08685	COG4166	transmembrane transport
GPY39_RS08690	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY39_RS08695	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY39_RS08700	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY39_RS08710	COG0539	negative regulation of cytoplasmic translation
GPY39_RS08715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY39_RS08720	COG0616	signal peptide processing
GPY39_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS08740	COG0587	DNA-directed DNA polymerase activity
GPY39_RS08745	COG0784	Response regulator, receiver
GPY39_RS08745	COG0835	chemotaxis
GPY39_RS08750	COG1940	carbohydrate kinase activity
GPY39_RS08755	COG0469	pyruvate kinase activity
GPY39_RS08760	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY39_RS08775	COG0733	neurotransmitter:sodium symporter activity
GPY39_RS08795	COG1263	PTS System
GPY39_RS08795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY39_RS08800	COG0084	hydrolase, TatD family'
GPY39_RS08810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY39_RS08815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY39_RS08845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY39_RS08850	COG0416	fatty acid biosynthetic process
GPY39_RS08860	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY39_RS08865	COG0424	maF-like protein
GPY39_RS08870	COG0564	pseudouridine synthase activity
GPY39_RS08875	COG1530	ribonuclease E activity
GPY39_RS08880	COG0659	secondary active sulfate transmembrane transporter activity
GPY39_RS08885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY39_RS08890	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY39_RS08900	COG0572	uridine kinase
GPY39_RS08905	COG0489	protein tyrosine kinase activity
GPY39_RS08910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY39_RS08910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY39_RS08920	COG2186	Transcriptional regulator
GPY39_RS08925	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY39_RS08930	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY39_RS08935	COG0653	protein targeting
GPY39_RS08940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY39_RS08945	COG0745	RESPONSE REGULATOR receiver
GPY39_RS08945	COG3706	GGDEF domain
GPY39_RS08950	COG0366	Alpha amylase catalytic
GPY39_RS08955	COG1122	ATPase activity
GPY39_RS08960	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY39_RS08970	COG3092	negative regulation of chromosome organization
GPY39_RS08975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY39_RS08980	COG0857	belongs to the CobB CobQ family
GPY39_RS08980	COG0280	phosphate acetyltransferase
GPY39_RS08985	COG3174	membrane
GPY39_RS08995	COG0435	Glutathione S-transferase
GPY39_RS09005	COG0444	Belongs to the ABC transporter superfamily
GPY39_RS09010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY39_RS09015	COG0601	transmembrane transport
GPY39_RS09025	COG0314	molybdopterin synthase activity
GPY39_RS09030	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY39_RS09035	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY39_RS09040	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY39_RS09045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY39_RS09050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY39_RS09055	COG2198	Histidine kinase
GPY39_RS09060	COG2204	response regulator
GPY39_RS09065	COG0556	nucleotide-excision repair
GPY39_RS09080	COG4657	Part of a membrane complex involved in electron transport
GPY39_RS09085	COG2878	Part of a membrane complex involved in electron transport
GPY39_RS09090	COG4656	Part of a membrane complex involved in electron transport
GPY39_RS09095	COG4658	electron transport chain
GPY39_RS09100	COG4659	FMN binding
GPY39_RS09105	COG4660	Part of a membrane complex involved in electron transport
GPY39_RS09110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY39_RS09115	COG0346	lactoylglutathione lyase activity
GPY39_RS09125	COG2885	chlorophyll binding
GPY39_RS09140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY39_RS09145	COG2056	Na+-H+ antiporter family
GPY39_RS09155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY39_RS09175	COG1454	alcohol dehydrogenase
GPY39_RS09175	COG1012	belongs to the aldehyde dehydrogenase family
GPY39_RS09180	COG2095	MarC family integral membrane protein
GPY39_RS09185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY39_RS09190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY39_RS09195	COG1757	Na H antiporter
GPY39_RS09210	COG3081	Nucleoid-associated protein
GPY39_RS09215	COG3082	Protein of unknown function (DUF1414)
GPY39_RS09220	COG3083	sulfuric ester hydrolase activity
GPY39_RS09230	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY39_RS09250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY39_RS09255	COG0778	Nitroreductase
GPY39_RS09260	COG1902	pentaerythritol trinitrate reductase activity
GPY39_RS09260	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY39_RS09265	COG0616	signal peptide processing
GPY39_RS09270	COG0252	asparaginase activity
GPY39_RS09275	COG3139	Protein of unknown function (DUF1315)
GPY39_RS09285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY39_RS09290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY39_RS09305	COG2226	methyltransferase
GPY39_RS09325	COG1785	Belongs to the alkaline phosphatase family
GPY39_RS09335	COG0346	lactoylglutathione lyase activity
GPY39_RS09345	COG0668	transmembrane transport
GPY39_RS09350	COG2983	Belongs to the UPF0260 family
GPY39_RS09355	COG2261	transglycosylase associated protein
GPY39_RS09370	COG3681	Belongs to the UPF0597 family
GPY39_RS09375	COG0251	oxidation-reduction process
GPY39_RS09380	COG0814	amino acid
GPY39_RS09385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY39_RS09390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY39_RS09395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY39_RS09405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY39_RS09410	COG2832	Protein of unknown function (DUF454)
GPY39_RS09420	COG0745	RESPONSE REGULATOR receiver
GPY39_RS09425	COG0583	DNA-binding transcription factor activity
GPY39_RS09430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY39_RS09435	COG1286	toxin biosynthetic process
GPY39_RS09440	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY39_RS09445	COG0285	dihydrofolate synthase activity
GPY39_RS09450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY39_RS09455	COG0101	tRNA pseudouridine synthase activity
GPY39_RS09465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY39_RS09470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY39_RS09475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY39_RS09480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY39_RS09480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY39_RS09485	COG0431	NADPH-dependent FMN reductase
GPY39_RS09500	COG3101	peptidyl-lysine hydroxylation
GPY39_RS09510	COG2860	membrane
GPY39_RS09515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY39_RS09520	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY39_RS09525	COG2840	Smr protein MutS2
GPY39_RS09530	COG2062	phosphohistidine phosphatase, SixA
GPY39_RS09545	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY39_RS09545	COG1024	Enoyl-CoA hydratase
GPY39_RS09550	COG0183	Belongs to the thiolase family
GPY39_RS09565	COG2067	long-chain fatty acid transport protein
GPY39_RS09570	COG2067	long-chain fatty acid transport protein
GPY39_RS09575	COG2853	Lipoprotein
GPY39_RS09590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY39_RS09595	COG1138	Cytochrome C-type biogenesis protein
GPY39_RS09600	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY39_RS09605	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY39_RS09610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY39_RS09615	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY39_RS09620	COG4133	protoheme IX ABC transporter activity
GPY39_RS09630	COG0835	chemotaxis
GPY39_RS09640	COG1192	Involved in chromosome partitioning
GPY39_RS09645	COG2201	protein-glutamate methylesterase activity
GPY39_RS09650	COG2198	Histidine kinase
GPY39_RS09650	COG0643	Histidine kinase
GPY39_RS09655	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY39_RS09670	COG0455	bacterial-type flagellum organization
GPY39_RS09690	COG1684	flagellar biosynthetic protein fliR
GPY39_RS09695	COG1987	bacterial-type flagellum assembly
GPY39_RS09745	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY39_RS09755	COG1677	Flagellar hook-basal body complex protein FliE
GPY39_RS09760	COG2204	response regulator
GPY39_RS09765	COG4191	Histidine kinase
GPY39_RS09775	COG1516	flagellar protein fliS
GPY39_RS09785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY39_RS09790	COG1334	flagellar protein FlaG
GPY39_RS09795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS09800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS09810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS09815	COG2837	iron assimilation
GPY39_RS09845	COG1393	Belongs to the ArsC family
GPY39_RS09850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY39_RS09870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY39_RS09875	COG2716	regulation of RNA biosynthetic process
GPY39_RS09880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY39_RS09895	COG4783	chaperone-mediated protein folding
GPY39_RS09900	COG1393	Belongs to the ArsC family
GPY39_RS09920	COG2233	PERMEase
GPY39_RS09925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY39_RS09930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY39_RS09935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY39_RS09940	COG0121	glutamine amidotransferase
GPY39_RS09945	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY39_RS09950	COG1960	acyl-CoA dehydrogenase activity
GPY39_RS09965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY39_RS09970	COG0328	RNA-DNA hybrid ribonuclease activity
GPY39_RS09975	COG2226	methyltransferase
GPY39_RS09980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY39_RS09985	COG0741	lytic transglycosylase activity
GPY39_RS09985	COG1388	LysM domain
GPY39_RS09995	COG3021	interspecies interaction between organisms
GPY39_RS10000	COG0347	Belongs to the P(II) protein family
GPY39_RS10010	COG0037	tRNA processing
GPY39_RS10015	COG0825	malonyl-CoA metabolic process
GPY39_RS10020	COG0587	DNA-directed DNA polymerase activity
GPY39_RS10030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY39_RS10035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY39_RS10040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY39_RS10045	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY39_RS10055	COG0750	zinc metalloprotease
GPY39_RS10060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY39_RS10065	COG0575	Belongs to the CDS family
GPY39_RS10070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY39_RS10075	COG0233	cytoplasmic translational termination
GPY39_RS10080	COG0528	UMP kinase activity
GPY39_RS10085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY39_RS10090	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY39_RS10095	COG0024	Methionine aminopeptidase
GPY39_RS10100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY39_RS10110	COG0564	pseudouridine synthase activity
GPY39_RS10115	COG3098	single-species biofilm formation
GPY39_RS10140	COG1671	Belongs to the UPF0178 family
GPY39_RS10145	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY39_RS10155	COG0254	rRNA binding
GPY39_RS10160	COG1720	tRNA m6t6A37 methyltransferase activity
GPY39_RS10165	COG0442	prolyl-tRNA aminoacylation
GPY39_RS10185	COG0733	neurotransmitter:sodium symporter activity
GPY39_RS10200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY39_RS10205	COG0514	ATP-dependent DNA helicase (RecQ)
GPY39_RS10210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY39_RS10225	COG1477	protein flavinylation
GPY39_RS10230	COG2871	sodium ion transport
GPY39_RS10235	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY39_RS10240	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY39_RS10245	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY39_RS10250	COG1805	sodium ion transport
GPY39_RS10255	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY39_RS10260	COG0271	Belongs to the BolA IbaG family
GPY39_RS10265	COG2813	Specifically methylates the guanine in position
GPY39_RS10270	COG3056	Lipoprotein
GPY39_RS10290	COG1595	DNA-templated transcription, initiation
GPY39_RS10315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY39_RS10320	COG0693	protein deglycase activity
GPY39_RS10325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY39_RS10330	COG3706	GGDEF domain
GPY39_RS10335	COG2166	iron-sulfur cluster assembly
GPY39_RS10340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY39_RS10345	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY39_RS10355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY39_RS10355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY39_RS10375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY39_RS10380	COG1074	ATP-dependent DNA helicase activity
GPY39_RS10385	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY39_RS10405	COG3141	response to X-ray
GPY39_RS10410	COG2171	N-acyltransferase activity
GPY39_RS10415	COG0584	glycerophosphoryl diester phosphodiesterase
GPY39_RS10420	COG2271	Major facilitator Superfamily
GPY39_RS10435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY39_RS10440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY39_RS10445	COG1349	DNA-binding transcription factor activity
GPY39_RS10450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY39_RS10455	COG0598	Magnesium transport protein CorA
GPY39_RS10475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY39_RS10480	COG1609	Transcriptional regulator
GPY39_RS10485	COG2176	DNA-directed DNA polymerase activity
GPY39_RS10500	COG2017	converts alpha-aldose to the beta-anomer
GPY39_RS10505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY39_RS10515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY39_RS10525	COG1609	Transcriptional regulator
GPY39_RS10530	COG3250	beta-galactosidase activity
GPY39_RS10535	COG2731	YhcH YjgK YiaL family protein
GPY39_RS10540	COG0531	amino acid
GPY39_RS10545	COG0583	DNA-binding transcription factor activity
GPY39_RS10605	COG4964	Belongs to the GSP D family
GPY39_RS10630	COG2169	Transcriptional regulator
GPY39_RS10635	COG1022	Amp-dependent synthetase and ligase
GPY39_RS10645	COG0583	DNA-binding transcription factor activity
GPY39_RS10650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY39_RS10655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY39_RS10665	COG0560	Phosphoserine phosphatase
GPY39_RS10675	COG0813	purine-nucleoside phosphorylase activity
GPY39_RS10680	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY39_RS10685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY39_RS10690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY39_RS10695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY39_RS10700	COG0084	hydrolase, TatD family'
GPY39_RS10710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY39_RS10730	COG3153	acetyltransferase
GPY39_RS10755	COG0534	Mate efflux family protein
GPY39_RS10770	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY39_RS10775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY39_RS10780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY39_RS10785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY39_RS10790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY39_RS10795	COG0195	Participates in both transcription termination and antitermination
GPY39_RS10800	COG0779	Required for maturation of 30S ribosomal subunits
GPY39_RS10815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY39_RS10825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY39_RS10830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY39_RS10835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY39_RS10840	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY39_RS10845	COG1534	Rna-binding protein
GPY39_RS10850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY39_RS10855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY39_RS10860	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY39_RS10870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY39_RS10875	COG0739	heme binding
GPY39_RS10880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY39_RS10890	COG0316	Belongs to the HesB IscA family
GPY39_RS10895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY39_RS10900	COG0628	permease
GPY39_RS10905	COG2813	Specifically methylates the guanine in position
GPY39_RS10910	COG2205	protein histidine kinase activity
GPY39_RS10910	COG2198	Histidine kinase
GPY39_RS10910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY39_RS10910	COG0784	Response regulator, receiver
GPY39_RS10915	COG0747	negative chemotaxis
GPY39_RS10925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY39_RS10930	COG0444	Belongs to the ABC transporter superfamily
GPY39_RS10935	COG4608	Belongs to the ABC transporter superfamily
GPY39_RS10945	COG2971	BadF BadG BcrA BcrD
GPY39_RS10960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY39_RS10965	COG3842	ATPase activity
GPY39_RS10975	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY39_RS10980	COG0004	ammonium transporteR
GPY39_RS10990	COG3112	Uncharacterised protein family (UPF0231)
GPY39_RS10995	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY39_RS11000	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY39_RS11005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY39_RS11010	COG1643	Atp-dependent helicase
GPY39_RS11015	COG1489	DNA binding
GPY39_RS11020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY39_RS11030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY39_RS11045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY39_RS11050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY39_RS11055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY39_RS11065	COG1560	Kdo2-lipid A biosynthetic process
GPY39_RS11070	COG0842	Transport permease protein
GPY39_RS11075	COG1131	(ABC) transporter
GPY39_RS11085	COG0659	secondary active sulfate transmembrane transporter activity
GPY39_RS11090	COG0288	reversible hydration of carbon dioxide
GPY39_RS11105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY39_RS11110	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY39_RS11115	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY39_RS11120	COG2186	Transcriptional regulator
GPY39_RS11130	COG0157	Belongs to the NadC ModD family
GPY39_RS11135	COG4969	Belongs to the N-Me-Phe pilin family
GPY39_RS11140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY39_RS11145	COG1459	type II secretion system
GPY39_RS11155	COG0237	dephospho-CoA kinase activity
GPY39_RS11160	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY39_RS11165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY39_RS11170	COG0335	large ribosomal subunit rRNA binding
GPY39_RS11175	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY39_RS11180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY39_RS11185	COG0228	four-way junction DNA binding
GPY39_RS11190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY39_RS11195	COG4137	Cytochrome C assembly protein
GPY39_RS11200	COG4536	flavin adenine dinucleotide binding
GPY39_RS11205	COG1854	S-ribosylhomocysteine lyase activity
GPY39_RS11215	COG2918	glutathione biosynthetic process
GPY39_RS11220	COG0612	Peptidase, M16
GPY39_RS11225	COG1238	metal cluster binding
GPY39_RS11235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY39_RS11240	COG0511	ligase activity, forming carbon-carbon bonds
GPY39_RS11240	COG5016	pyruvate
GPY39_RS11245	COG3630	sodium ion export across plasma membrane
GPY39_RS11305	COG0527	aspartate kinase activity
GPY39_RS11310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY39_RS11315	COG2137	regulation of response to DNA damage stimulus
GPY39_RS11320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY39_RS11325	COG1546	Belongs to the CinA family
GPY39_RS11330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY39_RS11345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY39_RS11350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY39_RS11355	COG0585	pseudouridine synthase activity
GPY39_RS11360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY39_RS11365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY39_RS11370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY39_RS11375	COG0148	phosphopyruvate hydratase activity
GPY39_RS11380	COG0504	CTP synthase activity
GPY39_RS11385	COG3956	TIGRFAM MazG family protein
GPY39_RS11390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY39_RS11400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY39_RS11410	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY39_RS11415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY39_RS11420	COG1381	Involved in DNA repair and RecF pathway recombination
GPY39_RS11425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY39_RS11430	COG0571	ribonuclease III activity
GPY39_RS11435	COG0681	Belongs to the peptidase S26 family
GPY39_RS11440	COG0481	GTPase activity
GPY39_RS11445	COG3086	response to oxidative stress
GPY39_RS11455	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY39_RS11460	COG1595	DNA-templated transcription, initiation
GPY39_RS11470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY39_RS11480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY39_RS11485	COG0354	folic acid binding
GPY39_RS11500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY39_RS11505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY39_RS11510	COG3079	Belongs to the UPF0149 family
GPY39_RS11520	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY39_RS11530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY39_RS11535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY39_RS11540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY39_RS11550	COG0583	DNA-binding transcription factor activity
GPY39_RS11560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY39_RS11565	COG0668	transmembrane transport
GPY39_RS11570	COG0191	fructose-bisphosphate aldolase activity
GPY39_RS11575	COG0126	phosphoglycerate kinase activity
GPY39_RS11580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY39_RS11585	COG4771	TonB-dependent receptor
GPY39_RS11590	COG0583	DNA-binding transcription factor activity
GPY39_RS11595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY39_RS11605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY39_RS11615	COG3091	SprT-like family
GPY39_RS11620	COG2356	endonuclease I
GPY39_RS11625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY39_RS11630	COG0189	ligase activity
GPY39_RS11635	COG1678	Uncharacterized ACR, COG1678
GPY39_RS11640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY39_RS11655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY39_RS11660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY39_RS11665	COG0762	integral membrane protein
GPY39_RS11670	COG1872	DUF167
GPY39_RS11680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY39_RS11685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY39_RS11690	COG2066	Belongs to the glutaminase family
GPY39_RS11700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY39_RS11710	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY39_RS11715	COG0741	lytic transglycosylase activity
GPY39_RS11785	COG1012	belongs to the aldehyde dehydrogenase family
GPY39_RS11845	COG3394	polysaccharide catabolic process
GPY39_RS11850	COG1486	melibiose metabolic process
GPY39_RS11855	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY39_RS11860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY39_RS11865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY39_RS11870	COG0726	polysaccharide deacetylase
GPY39_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS11905	COG4325	translation initiation factor activity
GPY39_RS11915	COG0795	lipopolysaccharide-transporting ATPase activity
GPY39_RS11920	COG0795	lipopolysaccharide-transporting ATPase activity
GPY39_RS11925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY39_RS11930	COG2927	DNA polymerase III (CHI subunit)
GPY39_RS11935	COG0525	valine-tRNA ligase activity
GPY39_RS11965	COG2235	arginine
GPY39_RS11970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY39_RS11980	COG0540	Belongs to the ATCase OTCase family
GPY39_RS11985	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY39_RS11990	COG0251	oxidation-reduction process
GPY39_RS11995	COG0204	Acyl-transferase
GPY39_RS12000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY39_RS12005	COG5007	Belongs to the BolA IbaG family
GPY39_RS12015	COG2854	intermembrane phospholipid transfer
GPY39_RS12020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY39_RS12025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY39_RS12030	COG1127	ABC transporter
GPY39_RS12040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY39_RS12040	COG0517	IMP dehydrogenase activity
GPY39_RS12050	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY39_RS12055	COG1137	ATPase activity
GPY39_RS12065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY39_RS12070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY39_RS12075	COG1660	Displays ATPase and GTPase activities
GPY39_RS12080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY39_RS12085	COG2239	Acts as a magnesium transporter
GPY39_RS12090	COG0312	modulator of DNA gyrase
GPY39_RS12095	COG3028	Belongs to the UPF0307 family
GPY39_RS12100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY39_RS12105	COG0564	pseudouridine synthase activity
GPY39_RS12120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY39_RS12125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY39_RS12130	COG0312	modulator of DNA gyrase
GPY39_RS12135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY39_RS12140	COG3164	Protein of unknown function
GPY39_RS12145	COG1530	ribonuclease E activity
GPY39_RS12150	COG0424	maF-like protein
GPY39_RS12155	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY39_RS12160	COG1792	Involved in formation and maintenance of cell shape
GPY39_RS12165	COG1077	Cell shape determining protein MreB Mrl
GPY39_RS12215	COG1459	type II secretion system
GPY39_RS12220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY39_RS12230	COG3409	Peptidoglycan-binding domain 1 protein
GPY39_RS12230	COG3267	Type II secretory pathway component ExeA
GPY39_RS12255	COG2199	diguanylate cyclase activity
GPY39_RS12255	COG2200	EAL domain
GPY39_RS12260	COG0629	single-stranded DNA binding
GPY39_RS12275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY39_RS12285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY39_RS12290	COG0527	aspartate kinase activity
GPY39_RS12295	COG0646	methionine synthase
GPY39_RS12295	COG1410	methionine synthase
GPY39_RS12360	COG0175	sulfate reduction
GPY39_RS12370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY39_RS12395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY39_RS12405	COG0735	belongs to the Fur family
GPY39_RS12415	COG0166	Belongs to the GPI family
GPY39_RS12420	COG0432	Pfam Uncharacterised protein family UPF0047
GPY39_RS12430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY39_RS12435	COG0305	Participates in initiation and elongation during chromosome replication
GPY39_RS12445	COG0359	binds to the 23S rRNA
GPY39_RS12455	COG2965	DNA replication, synthesis of RNA primer
GPY39_RS12460	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY39_RS12465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY39_RS12470	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY39_RS12480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY39_RS12485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY39_RS12515	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY39_RS12525	COG0678	peroxiredoxin activity
GPY39_RS12525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY39_RS12540	COG0165	Argininosuccinate lyase
GPY39_RS12540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY39_RS12545	COG0137	argininosuccinate synthase activity
GPY39_RS12550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY39_RS12555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY39_RS12560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY39_RS12565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY39_RS12575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY39_RS12580	COG0527	aspartate kinase activity
GPY39_RS12580	COG0460	homoserine dehydrogenase
GPY39_RS12585	COG0626	cystathionine gamma-synthase activity
GPY39_RS12595	COG0281	malic enzyme
GPY39_RS12605	COG2906	2 iron, 2 sulfur cluster binding
GPY39_RS12610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY39_RS12615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY39_RS12620	COG0049	tRNA binding
GPY39_RS12630	COG2168	tRNA wobble position uridine thiolation
GPY39_RS12635	COG2923	Belongs to the DsrF TusC family
GPY39_RS12640	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY39_RS12645	COG2964	Protein conserved in bacteria
GPY39_RS12650	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY39_RS12660	COG2900	Belongs to the SlyX family
GPY39_RS12665	COG1446	asparaginase
GPY39_RS12675	COG1047	Peptidyl-prolyl cis-trans
GPY39_RS12690	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY39_RS12700	COG0488	(ABC) transporter
GPY39_RS12710	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY39_RS12715	COG3089	Belongs to the UPF0270 family
GPY39_RS12720	COG3954	Phosphoribulokinase
GPY39_RS12725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY39_RS12735	COG1012	belongs to the aldehyde dehydrogenase family
GPY39_RS12745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY39_RS12750	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY39_RS12780	COG0180	Tryptophanyl-tRNA synthetase
GPY39_RS12785	COG0546	phosphoglycolate phosphatase activity
GPY39_RS12790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY39_RS12795	COG0557	exoribonuclease II activity
GPY39_RS12800	COG1959	2 iron, 2 sulfur cluster binding
GPY39_RS12805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY39_RS12805	COG1017	nitric oxide dioxygenase activity
GPY39_RS12810	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY39_RS12820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY39_RS12825	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY39_RS12830	COG0330	HflC and HflK could
GPY39_RS12835	COG0330	HflC and HflK could
GPY39_RS12840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY39_RS12850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY39_RS12855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY39_RS12860	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY39_RS12865	COG0802	atpase or kinase
GPY39_RS12870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY39_RS12940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY39_RS12945	COG1162	GTPase activity
GPY39_RS12950	COG0688	phosphatidylethanolamine metabolic process
GPY39_RS12955	COG0471	metal ion transport
GPY39_RS12970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY39_RS12975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY39_RS12980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY39_RS12985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY39_RS12990	COG1045	serine acetyltransferase
GPY39_RS12995	COG4942	peptidase
GPY39_RS13015	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY39_RS13025	COG1053	succinate dehydrogenase
GPY39_RS13030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY39_RS13035	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY39_RS13040	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY39_RS13050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY39_RS13055	COG1509	lysine 2,3-aminomutase activity
GPY39_RS13065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY39_RS13080	COG0459	protein refolding
GPY39_RS13085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY39_RS13090	COG0534	Mate efflux family protein
GPY39_RS13095	COG0205	6-phosphofructokinase activity
GPY39_RS13105	COG3678	ATP-independent chaperone mediated protein folding
GPY39_RS13110	COG0745	RESPONSE REGULATOR receiver
GPY39_RS13115	COG2205	protein histidine kinase activity
GPY39_RS13125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY39_RS13130	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY39_RS13135	COG1027	Aspartate ammonia-lyase
GPY39_RS13140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY39_RS13145	COG4232	protein-disulfide reductase activity
GPY39_RS13155	COG3263	regulation of cellular component size
GPY39_RS13165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY39_RS13190	COG0784	Response regulator, receiver
GPY39_RS13190	COG2205	protein histidine kinase activity
GPY39_RS13195	COG2814	Major facilitator Superfamily
GPY39_RS13210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY39_RS13215	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY39_RS13220	COG0511	ligase activity, forming carbon-carbon bonds
GPY39_RS13225	COG0439	Biotin carboxylase
GPY39_RS13235	COG2264	protein methyltransferase activity
GPY39_RS13240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY39_RS13245	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY39_RS13255	COG0488	(ABC) transporter
GPY39_RS13260	COG3706	GGDEF domain
GPY39_RS13265	COG3335	DDE superfamily endonuclease
GPY39_RS13325	COG1982	Orn Lys Arg decarboxylase major
GPY39_RS13330	COG0531	amino acid
GPY39_RS13340	COG3710	Transcriptional regulator
GPY39_RS13345	COG0789	Transcriptional regulator
GPY39_RS13355	COG0138	bifunctional purine biosynthesis protein purh
GPY39_RS13365	COG0151	Belongs to the GarS family
GPY39_RS13380	COG1253	flavin adenine dinucleotide binding
GPY39_RS13385	COG3068	Protein conserved in bacteria
GPY39_RS13390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY39_RS13395	COG1573	uracil-dna glycosylase
GPY39_RS13400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY39_RS13415	COG2816	NAD+ diphosphatase activity
GPY39_RS13420	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY39_RS13425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY39_RS13430	COG0085	RNA polymerase activity
GPY39_RS13435	COG0222	ribosome binding
GPY39_RS13440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY39_RS13445	COG0081	regulation of translation
GPY39_RS13450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY39_RS13455	COG0250	Participates in transcription elongation, termination and antitermination
GPY39_RS13460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY39_RS13470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY39_RS13505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY39_RS13515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY39_RS13570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY39_RS13580	COG4206	TonB-dependent receptor
GPY39_RS13585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY39_RS13600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY39_RS13605	COG0534	Mate efflux family protein
GPY39_RS13610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY39_RS13615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY39_RS13625	COG2937	Belongs to the GPAT DAPAT family
GPY39_RS13630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY39_RS13635	COG3161	chorismate lyase activity
GPY39_RS13640	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY39_RS13645	COG0705	Rhomboid family
GPY39_RS13650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY39_RS13660	COG2177	Part of the ABC transporter FtsEX involved in
GPY39_RS13665	COG2884	Cell division ATP-binding protein ftsE
GPY39_RS13670	COG0552	protein localization to endoplasmic reticulum
GPY39_RS13675	COG0742	ribosomal rna small subunit methyltransferase
GPY39_RS13685	COG2095	MarC family integral membrane protein
GPY39_RS13740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY39_RS13745	COG0640	Transcriptional regulator
GPY39_RS13750	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY39_RS13755	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS13760	COG2267	carboxylic ester hydrolase activity
GPY39_RS13765	COG0561	phosphatase activity
GPY39_RS13785	COG2200	EAL domain
GPY39_RS13785	COG2199	diguanylate cyclase activity
GPY39_RS13785	COG3287	FIST C domain
GPY39_RS13790	COG1011	Hydrolase
GPY39_RS13795	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY39_RS13805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY39_RS13810	COG0019	diaminopimelate decarboxylase activity
GPY39_RS13820	COG1965	Belongs to the frataxin family
GPY39_RS13825	COG3072	Adenylate cyclase
GPY39_RS13830	COG0181	hydroxymethylbilane synthase activity
GPY39_RS13835	COG1587	Uroporphyrinogen-III synthase
GPY39_RS13840	COG2959	enzyme of heme biosynthesis
GPY39_RS13845	COG3071	HemY protein
GPY39_RS13895	COG0633	Ferredoxin
GPY39_RS13900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY39_RS13915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY39_RS13920	COG3118	belongs to the thioredoxin family
GPY39_RS13925	COG0513	Belongs to the DEAD box helicase family
GPY39_RS13930	COG0248	Ppx GppA phosphatase
GPY39_RS13935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY39_RS13950	COG0514	ATP-dependent DNA helicase (RecQ)
GPY39_RS13955	COG2962	Rard protein
GPY39_RS13965	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS13970	COG0405	Gamma-glutamyltransferase
GPY39_RS13980	COG0210	DNA helicase
GPY39_RS13990	COG3220	belongs to the UPF0276 family
GPY39_RS14020	COG0006	proline dipeptidase activity
GPY39_RS14020	COG0006	proline dipeptidase activity
GPY39_RS14030	COG2022	thiamine diphosphate biosynthetic process
GPY39_RS14035	COG2104	thiamine diphosphate biosynthetic process
GPY39_RS14040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY39_RS14045	COG0352	thiamine-phosphate diphosphorylase activity
GPY39_RS14050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY39_RS14055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY39_RS14110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY39_RS14115	COG1739	Uncharacterized protein family UPF0029
GPY39_RS14120	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY39_RS14120	COG1024	Enoyl-CoA hydratase
GPY39_RS14125	COG0183	Belongs to the thiolase family
GPY39_RS14130	COG0604	alcohol dehydrogenase
GPY39_RS14145	COG0425	Belongs to the sulfur carrier protein TusA family
GPY39_RS14155	COG2119	membrane
GPY39_RS14160	COG0752	glycyl-tRNA synthetase alpha subunit
GPY39_RS14165	COG0751	glycine-tRNA ligase activity
GPY39_RS14170	COG0366	Alpha amylase catalytic
GPY39_RS14175	COG3977	Valine--pyruvate aminotransferase
GPY39_RS14180	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY39_RS14200	COG0187	DNA topoisomerase II activity
GPY39_RS14205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY39_RS14210	COG0592	DNA-directed DNA polymerase activity
GPY39_RS14215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY39_RS14240	COG1126	abc transporter atp-binding protein
GPY39_RS14250	COG0594	ribonuclease P activity
GPY39_RS14255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY39_RS14260	COG0706	membrane insertase activity
GPY39_RS14265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY39_RS14270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY39_RS14275	COG0445	tRNA wobble uridine modification
GPY39_RS14280	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY39_RS14285	COG1192	Involved in chromosome partitioning
GPY39_RS14290	COG1475	DNA binding
GPY39_RS14295	COG3312	ion transport
GPY39_RS14300	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY39_RS14315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY39_RS14320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY39_RS14325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY39_RS14330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY39_RS14335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY39_RS14340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY39_RS14345	COG0765	amino acid transport
GPY39_RS14350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY39_RS14355	COG2814	Major facilitator Superfamily
GPY39_RS14360	COG0583	DNA-binding transcription factor activity
GPY39_RS14370	COG0129	dihydroxy-acid dehydratase activity
GPY39_RS14375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY39_RS14380	COG3978	acetolactate synthase activity
GPY39_RS14390	COG0606	chelatase, subunit chli
GPY39_RS14400	COG0204	Acyl-transferase
GPY39_RS14405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY39_RS14410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY39_RS14420	COG3084	Protein conserved in bacteria
GPY39_RS14430	COG4326	sporulation control protein
GPY39_RS14435	COG1272	protein, Hemolysin III
GPY39_RS14445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY39_RS14450	COG0569	domain protein
GPY39_RS14455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY39_RS14455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY39_RS14460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY39_RS14465	COG0242	peptide deformylase activity
GPY39_RS14475	COG0758	DNA mediated transformation
GPY39_RS14480	COG2922	Belongs to the Smg family
GPY39_RS14485	COG0551	DNA topoisomerase type I activity
GPY39_RS14490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY39_RS14495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY39_RS14500	COG0009	L-threonylcarbamoyladenylate synthase
GPY39_RS14505	COG0408	coproporphyrinogen oxidase activity
GPY39_RS14510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY39_RS14520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY39_RS14560	COG0583	DNA-binding transcription factor activity
GPY39_RS14565	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY39_RS14570	COG2960	long-chain fatty acid transporting porin activity
GPY39_RS14580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY39_RS14585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS14650	COG4172	Belongs to the ABC transporter superfamily
GPY39_RS14655	COG0747	negative chemotaxis
GPY39_RS14665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY39_RS14705	COG1609	Transcriptional regulator
GPY39_RS14710	COG0583	DNA-binding transcription factor activity
GPY39_RS14720	COG2076	Multidrug Resistance protein
GPY39_RS14725	COG0129	dihydroxy-acid dehydratase activity
GPY39_RS14730	COG3265	gluconokinase activity
GPY39_RS14735	COG2610	gluconate transmembrane transporter activity
GPY39_RS14740	COG0800	Aldolase
GPY39_RS14745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY39_RS14750	COG0583	DNA-binding transcription factor activity
GPY39_RS14755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY39_RS14760	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY39_RS14765	COG0339	signal peptide processing
GPY39_RS14770	COG1522	sequence-specific DNA binding
GPY39_RS14775	COG5002	protein histidine kinase activity
GPY39_RS14775	COG5001	Diguanylate cyclase
GPY39_RS14780	COG0742	ribosomal rna small subunit methyltransferase
GPY39_RS14790	COG0697	spore germination
GPY39_RS14795	COG0589	response to stress
GPY39_RS14800	COG1528	Iron-storage protein
GPY39_RS14810	COG2081	HI0933 family
GPY39_RS14820	COG2823	Periplasmic or secreted lipoprotein
GPY39_RS14840	COG1597	lipid kinase activity
GPY39_RS14870	COG0628	permease
GPY39_RS14885	COG1322	Protein conserved in bacteria
GPY39_RS14890	COG2226	methyltransferase
GPY39_RS14895	COG3165	ubiquinone biosynthetic process from chorismate
GPY39_RS14900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY39_RS14905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY39_RS14910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY39_RS14915	COG0805	protein transport
GPY39_RS14925	COG0084	hydrolase, TatD family'
GPY39_RS14950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY39_RS14950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY39_RS14960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY39_RS14995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY39_RS15000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY39_RS15010	COG2204	response regulator
GPY39_RS15015	COG3852	Histidine kinase
GPY39_RS15025	COG0174	glutamine synthetase
GPY39_RS15045	COG1295	ribonuclease BN
GPY39_RS15050	COG1490	D-aminoacyl-tRNA deacylase activity
GPY39_RS15055	COG0456	acetyltransferase
GPY39_RS15065	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY39_RS15070	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY39_RS15075	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY39_RS15080	COG3031	protein transport across the cell outer membrane
GPY39_RS15090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY39_RS15095	COG1459	type II secretion system
GPY39_RS15100	COG2165	general secretion pathway protein
GPY39_RS15105	COG2165	general secretion pathway protein
GPY39_RS15110	COG2165	general secretion pathway protein
GPY39_RS15115	COG4795	General secretion pathway protein
GPY39_RS15120	COG3156	type II secretion system protein K
GPY39_RS15125	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY39_RS15130	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY39_RS15140	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY39_RS15145	COG0494	nUDIX hydrolase
GPY39_RS15150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY39_RS15150	COG0316	Belongs to the HesB IscA family
GPY39_RS15155	COG1040	competence protein
GPY39_RS15160	COG0596	Alpha beta hydrolase
GPY39_RS15170	COG2183	response to ionizing radiation
GPY39_RS15180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY39_RS15190	COG0745	RESPONSE REGULATOR receiver
GPY39_RS15195	COG2205	protein histidine kinase activity
GPY39_RS15200	COG2233	PERMEase
GPY39_RS15205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY39_RS15210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY39_RS15215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY39_RS15220	COG1758	RNA polymerase activity
GPY39_RS15225	COG0194	GDP metabolic process
GPY39_RS15240	COG0848	biopolymer transport protein
GPY39_RS15245	COG0811	peptide transport
GPY39_RS15270	COG4174	ABC transporter (Permease)
GPY39_RS15275	COG4239	(ABC) transporter, permease
GPY39_RS15280	COG0747	negative chemotaxis
GPY39_RS15285	COG0444	Belongs to the ABC transporter superfamily
GPY39_RS15290	COG4608	Belongs to the ABC transporter superfamily
GPY39_RS15300	COG1561	YicC-like family, N-terminal region
GPY39_RS15305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY39_RS15310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY39_RS15315	COG1560	Kdo2-lipid A biosynthetic process
GPY39_RS15320	COG1309	transcriptional regulator
GPY39_RS15325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY39_RS15340	COG2003	Belongs to the UPF0758 family
GPY39_RS15345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY39_RS15360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY39_RS15385	COG0463	Glycosyl transferase, family 2
GPY39_RS15390	COG0859	PFAM glycosyl transferase family 9
GPY39_RS15395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY39_RS15400	COG3642	lipopolysaccharide core region biosynthetic process
GPY39_RS15420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY39_RS15445	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY39_RS15450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY39_RS15465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY39_RS15470	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY39_RS15475	COG2089	acid synthase
GPY39_RS15485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GPY39_RS15490	COG1083	cytidylyl-transferase
GPY39_RS15500	COG1519	Transferase
GPY39_RS15505	COG0859	PFAM glycosyl transferase family 9
GPY39_RS15510	COG1560	Kdo2-lipid A biosynthetic process
GPY39_RS15520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY39_RS15540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY39_RS15570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY39_RS15575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY39_RS15600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY39_RS15610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY39_RS15615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY39_RS15620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY39_RS15655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY39_RS15665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY39_RS15685	COG0149	triose-phosphate isomerase activity
GPY39_RS15710	COG1494	fructose-1,6-bisphosphatase
GPY39_RS15720	COG3074	FtsZ-dependent cytokinesis
GPY39_RS15725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY39_RS15730	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY39_RS15735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY39_RS15740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY39_RS15750	COG1609	Transcriptional regulator
GPY39_RS15755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY39_RS15765	COG0254	rRNA binding
GPY39_RS15775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY39_RS15780	COG0088	Forms part of the polypeptide exit tunnel
GPY39_RS15790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY39_RS15795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY39_RS15800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY39_RS15805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY39_RS15815	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY39_RS15820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY39_RS15825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY39_RS15830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY39_RS15835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY39_RS15840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY39_RS15845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY39_RS15850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY39_RS15865	COG1841	ribosomal large subunit assembly
GPY39_RS15870	COG0200	Binds to the 23S rRNA
GPY39_RS15875	COG0201	protein transport
GPY39_RS15885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY39_RS15890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY39_RS15900	COG0202	RNA polymerase activity
GPY39_RS15905	COG0203	ribosomal protein L17
GPY39_RS15915	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY39_RS15925	COG2153	protein acetylation
GPY39_RS15930	COG0513	Belongs to the DEAD box helicase family
GPY39_RS15945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY39_RS15945	COG1648	precorrin-2 dehydrogenase activity
GPY39_RS15950	COG0175	sulfate reduction
GPY39_RS15955	COG2895	sulfate adenylyltransferase (ATP) activity
GPY39_RS15965	COG3273	potassium ion transport
GPY39_RS15965	COG0471	metal ion transport
GPY39_RS15970	COG0529	Catalyzes the synthesis of activated sulfate
GPY39_RS15990	COG4181	ATPase activity
GPY39_RS16005	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY39_RS16015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY39_RS16020	COG0729	surface antigen
GPY39_RS16030	COG2105	PFAM AIG2 family protein
GPY39_RS16040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY39_RS16045	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY39_RS16055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY39_RS16060	COG0163	prenyltransferase activity
GPY39_RS16065	COG4143	(ABC) transporter
GPY39_RS16070	COG1178	ABC-type Fe3 transport system permease component
GPY39_RS16075	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY39_RS16110	COG0039	L-malate dehydrogenase activity
GPY39_RS16120	COG0142	geranyltranstransferase activity
GPY39_RS16125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY39_RS16135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY39_RS16140	COG2966	Psort location CytoplasmicMembrane, score
GPY39_RS16155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY39_RS16160	COG2967	ApaG domain
GPY39_RS16165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY39_RS16170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY39_RS16175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY39_RS16180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY39_RS16185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY39_RS16195	COG0066	3-isopropylmalate dehydratase activity
GPY39_RS16200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY39_RS16205	COG0473	3-isopropylmalate dehydrogenase activity
GPY39_RS16210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY39_RS16235	COG0583	DNA-binding transcription factor activity
GPY39_RS16240	COG1022	Amp-dependent synthetase and ligase
GPY39_RS16245	COG0028	Belongs to the TPP enzyme family
GPY39_RS16250	COG0440	acetolactate synthase activity
GPY39_RS16255	COG3706	GGDEF domain
GPY39_RS16265	COG0469	pyruvate kinase activity
GPY39_RS16275	COG1349	DNA-binding transcription factor activity
GPY39_RS16280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY39_RS16295	COG5002	protein histidine kinase activity
GPY39_RS16300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY39_RS16305	COG3722	fumarate hydratase activity
GPY39_RS16310	COG0246	Mannitol dehydrogenase
GPY39_RS16315	COG2213	PTS system mannitol-specific
GPY39_RS16315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY39_RS16350	COG1464	Belongs to the NlpA lipoprotein family
GPY39_RS16370	COG5507	3-demethylubiquinone-9 3-methyltransferase
GPY39_RS16450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY39_RS16455	COG0358	DNA primase activity
GPY39_RS16460	COG1610	YqeY-like protein
GPY39_RS16465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY39_RS16470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY39_RS16475	COG0596	Alpha beta hydrolase
GPY39_RS16480	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY39_RS16485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY39_RS16490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY39_RS16495	COG1968	undecaprenyl-diphosphatase activity
GPY39_RS16500	COG0617	tRNA 3'-terminal CCA addition
GPY39_RS16505	COG3409	Peptidoglycan-binding domain 1 protein
GPY39_RS16505	COG3267	Type II secretory pathway component ExeA
GPY39_RS16515	COG4991	sh3 domain protein
GPY39_RS16520	COG0306	phosphate transporter
GPY39_RS16525	COG1392	Phosphate transport regulator
GPY39_RS16530	COG3025	triphosphatase activity
GPY39_RS16545	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY39_RS16550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY39_RS16550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY39_RS16555	COG1538	Outer membrane efflux protein
GPY39_RS16560	COG0494	nUDIX hydrolase
GPY39_RS16565	COG3151	Protein conserved in bacteria
GPY39_RS16575	COG3150	esterase
GPY39_RS16580	COG0187	DNA topoisomerase II activity
GPY39_RS16590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY39_RS16600	COG3105	Protein conserved in bacteria
GPY39_RS16610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY39_RS16620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY39_RS16625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY39_RS16630	COG0723	plastoquinol--plastocyanin reductase activity
GPY39_RS16635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY39_RS16640	COG2857	Cytochrome c1
GPY39_RS16645	COG0625	glutathione transferase activity
GPY39_RS16650	COG2969	positive regulation of protein catabolic process
GPY39_RS16655	COG2823	Periplasmic or secreted lipoprotein
GPY39_RS16660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY39_RS16665	COG0792	nuclease activity
GPY39_RS16675	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY39_RS16690	COG0275	rRNA processing
GPY39_RS16695	COG3116	cell division
GPY39_RS16700	COG0768	penicillin binding
GPY39_RS16705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY39_RS16710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY39_RS16715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY39_RS16720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY39_RS16725	COG0772	Belongs to the SEDS family
GPY39_RS16730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY39_RS16735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY39_RS16740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY39_RS16745	COG0849	cell division
GPY39_RS16750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY39_RS16755	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY39_RS16765	COG0653	protein targeting
GPY39_RS16770	COG0494	nUDIX hydrolase
GPY39_RS16775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY39_RS16780	COG0505	Belongs to the CarA family
GPY39_RS16785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY39_RS16800	COG0730	response to heat
GPY39_RS16805	COG0583	DNA-binding transcription factor activity
GPY39_RS16810	COG2860	membrane
GPY39_RS16815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY39_RS16825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY39_RS16835	COG0493	'glutamate synthase
GPY39_RS16840	COG0067	glutamate synthase
GPY39_RS16840	COG0069	glutamate synthase activity
GPY39_RS16840	COG0070	glutamate synthase
GPY39_RS16850	COG0070	glutamate synthase
GPY39_RS16850	COG0067	glutamate synthase
GPY39_RS16850	COG0069	glutamate synthase activity
GPY39_RS16855	COG1242	4 iron, 4 sulfur cluster binding
GPY39_RS16860	COG5001	Diguanylate cyclase
GPY39_RS16860	COG4251	negative regulation of phosphorylation
GPY39_RS16860	COG3706	GGDEF domain
GPY39_RS16860	COG2203	Gaf domain
GPY39_RS16865	COG2198	Histidine kinase
GPY39_RS16865	COG0784	Response regulator, receiver
GPY39_RS16865	COG5002	protein histidine kinase activity
GPY39_RS16875	COG0745	RESPONSE REGULATOR receiver
GPY39_RS16890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY39_RS16905	COG0083	homoserine kinase activity
GPY39_RS16910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY39_RS16915	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY39_RS16920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY39_RS16930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY39_RS16945	COG1115	amino acid carrier protein
GPY39_RS16950	COG3022	response to hydroperoxide
GPY39_RS16955	COG0513	Belongs to the DEAD box helicase family
GPY39_RS16960	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY39_RS16970	COG0716	FMN binding
GPY39_RS16980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY39_RS16985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY39_RS16995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY39_RS17010	COG0667	Aldo Keto reductase
GPY39_RS17020	COG3066	DNA modification
GPY39_RS17030	COG0494	nUDIX hydrolase
GPY39_RS17040	COG0730	response to heat
GPY39_RS17045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY39_RS17050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY39_RS17060	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY39_RS17065	COG0583	DNA-binding transcription factor activity
GPY39_RS17075	COG0640	Transcriptional regulator
GPY39_RS17085	COG0268	Binds directly to 16S ribosomal RNA
GPY39_RS17090	COG0728	peptidoglycan biosynthetic process
GPY39_RS17095	COG0196	riboflavin kinase activity
GPY39_RS17100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY39_RS17105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY39_RS17110	COG1047	Peptidyl-prolyl cis-trans
GPY39_RS17115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY39_RS17120	COG3279	Response regulator of the LytR AlgR family
GPY39_RS17125	COG3275	phosphorelay sensor kinase activity
GPY39_RS17130	COG1966	Carbon starvation protein
GPY39_RS17145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY39_RS17150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY39_RS17155	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY39_RS17160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY39_RS17165	COG0287	Prephenate dehydrogenase
GPY39_RS17165	COG1605	Chorismate mutase
GPY39_RS17170	COG0739	heme binding
GPY39_RS17185	COG0488	(ABC) transporter
GPY39_RS17195	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY39_RS17200	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY39_RS17205	COG0077	Prephenate dehydratase
GPY39_RS17205	COG1605	Chorismate mutase
GPY39_RS17210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY39_RS17215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY39_RS17220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY39_RS17225	COG0564	pseudouridine synthase activity
GPY39_RS17235	COG0542	response to heat
GPY39_RS17295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY39_RS17300	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY39_RS17305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY39_RS17325	COG3437	response regulator, receiver
GPY39_RS17325	COG0784	Response regulator, receiver
GPY39_RS17335	COG0546	phosphoglycolate phosphatase activity
GPY39_RS17340	COG0840	transmembrane signaling receptor activity
GPY39_RS17350	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY39_RS17355	COG0513	Belongs to the DEAD box helicase family
GPY39_RS17360	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY39_RS17375	COG3038	cytochrome b561
GPY39_RS17380	COG2353	YceI-like domain
GPY39_RS17385	COG2116	formate transmembrane transporter activity
GPY39_RS17390	COG0583	DNA-binding transcription factor activity
GPY39_RS17400	COG3593	DNA synthesis involved in DNA repair
GPY39_RS17405	COG0737	Belongs to the 5'-nucleotidase family
GPY39_RS17410	COG0861	Integral membrane protein TerC family
GPY39_RS17425	COG2267	carboxylic ester hydrolase activity
GPY39_RS17430	COG2067	long-chain fatty acid transport protein
GPY39_RS17445	COG2050	protein possibly involved in aromatic compounds catabolism
GPY39_RS17455	COG4533	DNA binding
GPY39_RS17480	COG0484	heat shock protein binding
GPY39_RS17490	COG5001	Diguanylate cyclase
GPY39_RS17490	COG3300	MHYT domain
GPY39_RS17495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY39_RS17505	COG4181	ATPase activity
GPY39_RS17510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY39_RS17520	COG1984	allophanate hydrolase subunit 2
GPY39_RS17525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY39_RS17530	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY39_RS17535	COG5002	protein histidine kinase activity
GPY39_RS17535	COG3447	MASE1 domain protein
GPY39_RS17535	COG5001	Diguanylate cyclase
GPY39_RS17540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY39_RS17555	COG0583	DNA-binding transcription factor activity
GPY39_RS17560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY39_RS17560	COG1042	CoA-binding domain protein
GPY39_RS17560	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY39_RS17570	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY39_RS17580	COG0023	Translation Initiation Factor
GPY39_RS17735	COG0583	DNA-binding transcription factor activity
GPY39_RS17745	COG0589	response to stress
GPY39_RS17750	COG3140	Belongs to the UPF0181 family
GPY39_RS17775	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY39_RS17780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY39_RS17795	COG3706	GGDEF domain
GPY39_RS17795	COG0745	RESPONSE REGULATOR receiver
GPY39_RS17805	COG4251	negative regulation of phosphorylation
GPY39_RS17805	COG3706	GGDEF domain
GPY39_RS17805	COG2203	Gaf domain
GPY39_RS17805	COG5001	Diguanylate cyclase
GPY39_RS17815	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY39_RS17820	COG4149	molybdate abc transporter
GPY39_RS17825	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY39_RS17830	COG1492	cobalamin metabolic process
GPY39_RS17835	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY39_RS17845	COG0189	ligase activity
GPY39_RS17845	COG4067	protein conserved in archaea
GPY39_RS17865	COG0534	Mate efflux family protein
GPY39_RS17870	COG0602	queuosine metabolic process
GPY39_RS17875	COG1328	CTP reductase activity
GPY39_RS17890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY39_RS17920	COG0243	molybdopterin cofactor binding
GPY39_RS17930	COG0583	DNA-binding transcription factor activity
GPY39_RS17935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY39_RS17945	COG2197	response regulator
GPY39_RS17950	COG3851	Histidine kinase
GPY39_RS17955	COG2271	Major facilitator Superfamily
GPY39_RS17960	COG1482	cell wall glycoprotein biosynthetic process
GPY39_RS17980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY39_RS17985	COG3118	belongs to the thioredoxin family
GPY39_RS17990	COG2814	Major facilitator Superfamily
GPY39_RS18000	COG0534	Mate efflux family protein
GPY39_RS18030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY39_RS18050	COG2116	formate transmembrane transporter activity
GPY39_RS18055	COG2146	nitrite reductase [NAD(P)H] activity
GPY39_RS18060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY39_RS18065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY39_RS18105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY39_RS18105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY39_RS18150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY39_RS18170	COG0277	FAD linked oxidase domain protein
GPY39_RS18175	COG0583	DNA-binding transcription factor activity
GPY39_RS18195	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY39_RS18210	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY39_RS18225	COG1288	antiporter activity
GPY39_RS18235	COG2814	Major facilitator Superfamily
GPY39_RS18245	COG3040	lipid binding
GPY39_RS18265	COG0419	ATPase involved in DNA repair
GPY39_RS18270	COG0420	3'-5' exonuclease activity
GPY39_RS18285	COG3501	Rhs element vgr protein
GPY39_RS18340	COG0631	protein serine/threonine phosphatase activity
GPY39_RS18375	COG2815	serine threonine protein kinase
GPY39_RS18375	COG0515	serine threonine protein kinase
GPY39_RS18430	COG2146	nitrite reductase [NAD(P)H] activity
GPY39_RS18430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY39_RS18435	COG1116	anion transmembrane transporter activity
GPY39_RS18440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY39_RS18445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY39_RS18445	COG1116	anion transmembrane transporter activity
GPY39_RS18455	COG3707	response regulator
GPY39_RS18475	COG1648	precorrin-2 dehydrogenase activity
GPY39_RS18475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY39_RS18480	COG0243	molybdopterin cofactor binding
GPY39_RS18485	COG0456	acetyltransferase
GPY39_RS18490	COG0814	amino acid
GPY39_RS18500	COG3706	GGDEF domain
GPY39_RS18500	COG0745	RESPONSE REGULATOR receiver
GPY39_RS18520	COG1785	Belongs to the alkaline phosphatase family
GPY39_RS18535	COG0745	RESPONSE REGULATOR receiver
GPY39_RS18565	COG2847	Copper chaperone PCu(A)C
GPY39_RS18570	COG0443	Heat shock 70 kDa protein
GPY39_RS18605	COG0625	glutathione transferase activity
GPY39_RS18620	COG4160	amino acid transport
GPY39_RS18625	COG4215	(ABC) transporter
GPY39_RS18630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY39_RS18635	COG1126	abc transporter atp-binding protein
GPY39_RS18645	COG1902	pentaerythritol trinitrate reductase activity
GPY39_RS18660	COG0109	protoheme IX farnesyltransferase activity
GPY39_RS18665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY39_RS18670	COG1845	cytochrome c oxidase, subunit III
GPY39_RS18675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY39_RS18680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY39_RS18695	COG1024	Enoyl-CoA hydratase
GPY39_RS18700	COG1024	Enoyl-CoA hydratase
GPY39_RS18715	COG0183	Belongs to the thiolase family
GPY39_RS18725	COG1960	acyl-CoA dehydrogenase activity
GPY39_RS18730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY39_RS18735	COG1024	Enoyl-CoA hydratase
GPY39_RS18745	COG5413	integral membrane protein
GPY39_RS18760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY39_RS18770	COG5001	Diguanylate cyclase
GPY39_RS18775	COG0513	Belongs to the DEAD box helicase family
GPY39_RS18780	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY39_RS18795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY39_RS18815	COG0641	radical SAM
GPY39_RS18840	COG0840	transmembrane signaling receptor activity
GPY39_RS18845	COG1119	ATPase activity
GPY39_RS18850	COG2200	EAL domain
GPY39_RS18870	COG0513	Belongs to the DEAD box helicase family
GPY39_RS18875	COG0523	cobalamin synthesis protein
GPY39_RS18885	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY39_RS18895	COG0133	tryptophan synthase activity
GPY39_RS18900	COG4628	conserved protein (DUF2132)
GPY39_RS18905	COG0513	Belongs to the DEAD box helicase family
GPY39_RS18910	COG3530	Putative quorum-sensing-regulated virulence factor
GPY39_RS18935	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY39_RS18940	COG3186	Phenylalanine-4-hydroxylase
GPY39_RS18945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY39_RS18950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY39_RS18990	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY39_RS18995	COG1454	alcohol dehydrogenase
GPY39_RS19000	COG2133	pyrroloquinoline quinone binding
GPY39_RS19010	COG0783	Belongs to the Dps family
GPY39_RS19015	COG0840	transmembrane signaling receptor activity
GPY39_RS19025	COG1136	(ABC) transporter
GPY39_RS19025	COG0577	efflux transmembrane transporter activity
GPY39_RS19045	COG2199	diguanylate cyclase activity
GPY39_RS19060	COG3036	rescue of stalled ribosome
GPY39_RS19065	COG1278	Cold shock
GPY39_RS19100	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY39_RS19105	COG0109	protoheme IX farnesyltransferase activity
GPY39_RS19110	COG1612	heme a metabolic process
GPY39_RS19135	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY39_RS19145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY39_RS19150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY39_RS19160	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS19165	COG2207	Transcriptional regulator
GPY39_RS19195	COG0697	spore germination
GPY39_RS19220	COG2814	Major facilitator Superfamily
GPY39_RS19225	COG0583	DNA-binding transcription factor activity
GPY39_RS19230	COG5001	Diguanylate cyclase
GPY39_RS19235	COG0739	heme binding
GPY39_RS19275	COG0814	amino acid
GPY39_RS19295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY39_RS19300	COG1072	(Pantothenic acid kinase))
GPY39_RS19310	COG1063	alcohol dehydrogenase
GPY39_RS19315	COG2213	PTS system mannitol-specific
GPY39_RS19320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY39_RS19340	COG0798	PFAM Bile acid sodium symporter
GPY39_RS19350	COG1881	PFAM PEBP family protein
GPY39_RS19360	COG2706	6-phosphogluconolactonase activity
GPY39_RS19375	COG1131	(ABC) transporter
GPY39_RS19380	COG0842	Transport permease protein
GPY39_RS19395	COG3383	formate dehydrogenase (NAD+) activity
GPY39_RS19420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY39_RS19440	COG2199	diguanylate cyclase activity
GPY39_RS19440	COG2203	Gaf domain
GPY39_RS19450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY39_RS19460	COG2067	long-chain fatty acid transport protein
GPY39_RS19470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS19480	COG1505	serine-type exopeptidase activity
GPY39_RS19490	COG0589	response to stress
GPY39_RS19495	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY39_RS19515	COG0366	Alpha amylase catalytic
GPY39_RS19525	COG4934	collagen metabolic process
GPY39_RS19540	COG0583	DNA-binding transcription factor activity
GPY39_RS19550	COG0783	Belongs to the Dps family
GPY39_RS19555	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY39_RS19595	COG2814	Major facilitator Superfamily
GPY39_RS19610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY39_RS19620	COG0835	chemotaxis
GPY39_RS19620	COG0784	Response regulator, receiver
GPY39_RS19630	COG0748	coenzyme F420 binding
GPY39_RS19635	COG3721	Heme iron utilization protein
GPY39_RS19645	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY39_RS19650	COG0811	peptide transport
GPY39_RS19655	COG0848	biopolymer transport protein
GPY39_RS19665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY39_RS19670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY39_RS19710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY39_RS19715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY39_RS19720	COG3217	Mosc domain protein beta barrel domain protein
GPY39_RS19720	COG0633	Ferredoxin
GPY39_RS19720	COG3217	Mosc domain protein beta barrel domain protein
GPY39_RS19720	COG0633	Ferredoxin
GPY39_RS19730	COG0401	homolog of Blt101
GPY39_RS19740	COG0418	dihydroorotase activity
GPY39_RS19745	COG2354	Protein conserved in bacteria
GPY39_RS19775	COG0183	Belongs to the thiolase family
GPY39_RS19855	COG0804	urea catabolic process
GPY39_RS19875	COG0747	negative chemotaxis
GPY39_RS19885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY39_RS19890	COG4172	Belongs to the ABC transporter superfamily
GPY39_RS19900	COG2207	Transcriptional regulator
GPY39_RS19920	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY39_RS20010	COG4790	Type iii secretion
GPY39_RS20025	COG3710	Transcriptional regulator
GPY39_RS20055	COG4792	protein secretion
GPY39_RS20060	COG4789	Type iii secretion
GPY39_RS20165	COG2199	diguanylate cyclase activity
GPY39_RS20165	COG2202	Pas domain
GPY39_RS20165	COG2200	EAL domain
GPY39_RS20295	COG3833	ABC-type maltose transport systems, permease component
GPY39_RS20300	COG1175	transmembrane transport
GPY39_RS20310	COG3842	ATPase activity
GPY39_RS20375	COG1309	transcriptional regulator
GPY39_RS20380	COG2130	NADP-dependent
GPY39_RS20390	COG0753	catalase activity
GPY39_RS20395	COG2084	Dehydrogenase
GPY39_RS20400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY39_RS20405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY39_RS20415	COG2207	Transcriptional regulator
GPY39_RS20420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY39_RS20420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY39_RS20420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY39_RS20435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY39_RS20440	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY39_RS20450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY39_RS20455	COG0569	domain protein
GPY39_RS20465	COG5002	protein histidine kinase activity
GPY39_RS20470	COG1132	(ABC) transporter
GPY39_RS20475	COG4774	siderophore transport
GPY39_RS20480	COG1120	ATPase activity
GPY39_RS20485	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY39_RS20535	COG2197	response regulator
GPY39_RS20545	COG0840	transmembrane signaling receptor activity
GPY39_RS20555	COG0714	Associated with various cellular activities
GPY39_RS20575	COG2304	oxidoreductase activity
GPY39_RS20590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY39_RS20595	COG0581	inorganic phosphate transmembrane transporter activity
GPY39_RS20600	COG0573	inorganic phosphate transmembrane transporter activity
GPY39_RS20605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY39_RS20630	COG4771	TonB-dependent receptor
GPY39_RS20635	COG1770	oligopeptidase
GPY39_RS20640	COG0513	Belongs to the DEAD box helicase family
GPY39_RS20650	COG1388	LysM domain
GPY39_RS20650	COG1376	ErfK ybiS ycfS ynhG family protein
GPY39_RS20655	COG0415	Belongs to the DNA photolyase family
GPY39_RS20660	COG0789	Transcriptional regulator
GPY39_RS20665	COG3272	Protein of unknown function (DUF1722)
GPY39_RS20675	COG0813	purine-nucleoside phosphorylase activity
GPY39_RS20690	COG3706	GGDEF domain
GPY39_RS20700	COG1566	PFAM secretion protein HlyD family protein
GPY39_RS20705	COG4720	Psort location CytoplasmicMembrane, score
GPY39_RS20710	COG1122	ATPase activity
GPY39_RS20725	COG0348	domain, Protein
GPY39_RS20730	COG0437	4 iron, 4 sulfur cluster binding
GPY39_RS20735	COG1247	-acetyltransferase
GPY39_RS20765	COG1067	ATP-dependent peptidase activity
GPY39_RS20775	COG4172	Belongs to the ABC transporter superfamily
GPY39_RS20785	COG0583	DNA-binding transcription factor activity
GPY39_RS20790	COG1620	l-lactate permease
GPY39_RS20795	COG1304	FMN binding
GPY39_RS20805	COG0668	transmembrane transport
GPY39_RS20845	COG1063	alcohol dehydrogenase
GPY39_RS20850	COG0156	8-amino-7-oxononanoate synthase activity
GPY39_RS20860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY39_RS20880	COG0745	RESPONSE REGULATOR receiver
GPY39_RS20915	COG0346	lactoylglutathione lyase activity
GPY39_RS20935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY39_RS20975	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY39_RS20990	COG2204	response regulator
GPY39_RS21015	COG1987	bacterial-type flagellum assembly
GPY39_RS21025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY39_RS21040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS21060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY39_RS21065	COG1516	flagellar protein fliS
GPY39_RS21080	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY39_RS21085	COG1191	sigma factor activity
GPY39_RS21090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY39_RS21095	COG1360	Flagellar Motor Protein
GPY39_RS21150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY39_RS21155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY39_RS21165	COG0454	-acetyltransferase
GPY39_RS21180	COG2814	Major facilitator Superfamily
GPY39_RS21225	COG0628	permease
GPY39_RS21230	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY39_RS21240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY39_RS21250	COG4628	conserved protein (DUF2132)
GPY39_RS21255	COG0583	DNA-binding transcription factor activity
GPY39_RS21280	COG1686	Belongs to the peptidase S11 family
GPY39_RS21300	COG3397	chitin binding
GPY39_RS21305	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY39_RS21310	COG2095	MarC family integral membrane protein
GPY39_RS21325	COG1596	polysaccharide export
GPY39_RS21330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY39_RS21350	COG0583	DNA-binding transcription factor activity
GPY39_RS21360	COG1301	dicarboxylic acid transport
GPY39_RS21365	COG3339	Conserved Protein
GPY39_RS21370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY39_RS21375	COG0700	Nucleoside recognition
GPY39_RS21380	COG3366	ferrous iron transmembrane transporter activity
GPY39_RS21395	COG0366	Alpha amylase catalytic
GPY39_RS21400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY39_RS21405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY39_RS21410	COG1640	4-alpha-glucanotransferase
GPY39_RS21415	COG0058	SHG alpha-glucan phosphorylase activity
GPY39_RS21430	COG2909	trisaccharide binding
GPY39_RS21445	COG1999	signal sequence binding
GPY39_RS21455	COG1263	PTS System
GPY39_RS21455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY39_RS21460	COG1162	GTPase activity
GPY39_RS21465	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY39_RS21475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY39_RS21485	COG0531	amino acid
GPY39_RS21490	COG1982	Orn Lys Arg decarboxylase major
GPY39_RS21510	COG2356	endonuclease I
GPY39_RS21560	COG0739	heme binding
GPY39_RS21570	COG0612	Peptidase, M16
GPY39_RS21575	COG0840	transmembrane signaling receptor activity
GPY39_RS21580	COG1120	ATPase activity
GPY39_RS21585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY39_RS21590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY39_RS21595	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY39_RS21600	COG4772	TonB-dependent receptor
GPY39_RS21625	COG4264	IucA IucC family
GPY39_RS21630	COG0019	diaminopimelate decarboxylase activity
GPY39_RS21635	COG1653	transport
GPY39_RS21645	COG0745	RESPONSE REGULATOR receiver
GPY39_RS21685	COG0463	Glycosyl transferase, family 2
GPY39_RS21705	COG1764	response to oxidative stress
GPY39_RS21710	COG1846	Transcriptional regulator
GPY39_RS21715	COG0450	alkyl hydroperoxide reductase
GPY39_RS21720	COG3634	alkyl hydroperoxide reductase activity
GPY39_RS21750	COG1595	DNA-templated transcription, initiation
GPY39_RS21765	COG0840	transmembrane signaling receptor activity
GPY39_RS21770	COG0583	DNA-binding transcription factor activity
GPY39_RS21775	COG1486	melibiose metabolic process
GPY39_RS21790	COG2258	MOSC domain
GPY39_RS21795	COG0513	Belongs to the DEAD box helicase family
GPY39_RS21810	COG2207	Transcriptional regulator
GPY39_RS21820	COG1132	(ABC) transporter
GPY39_RS21865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY39_RS21895	COG0259	pyridoxamine-phosphate oxidase activity
GPY39_RS22020	COG4166	transmembrane transport
GPY39_RS22040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY39_RS22045	COG1263	PTS System
GPY39_RS22045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY39_RS22050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY39_RS22055	COG3340	Belongs to the peptidase S51 family
GPY39_RS22075	COG1444	tRNA N-acetyltransferase activity
GPY39_RS22100	COG4608	Belongs to the ABC transporter superfamily
GPY39_RS22105	COG0444	Belongs to the ABC transporter superfamily
GPY39_RS22115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY39_RS22115	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY39_RS22140	COG0217	transcriptional regulatory protein
GPY39_RS22145	COG0772	Belongs to the SEDS family
GPY39_RS22180	COG3275	phosphorelay sensor kinase activity
GPY39_RS22185	COG3279	Response regulator of the LytR AlgR family
GPY39_RS22195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY39_RS22230	COG0786	glutamate:sodium symporter activity
GPY39_RS22240	COG1131	(ABC) transporter
GPY39_RS22245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY39_RS22250	COG0786	glutamate:sodium symporter activity
GPY39_RS22265	COG0363	glucosamine-6-phosphate deaminase activity
GPY39_RS22285	COG1741	Belongs to the pirin family
GPY39_RS22290	COG2259	Doxx family
GPY39_RS22305	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY39_RS22310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY39_RS22320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY39_RS22360	COG3123	guanosine phosphorylase activity
GPY39_RS22370	COG5001	Diguanylate cyclase
GPY39_RS22380	COG0534	Mate efflux family protein
GPY39_RS22385	COG0564	pseudouridine synthase activity
GPY39_RS22400	COG0583	DNA-binding transcription factor activity
GPY39_RS22405	COG0561	phosphatase activity
GPY39_RS22415	COG2199	diguanylate cyclase activity
GPY39_RS22430	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY39_RS22435	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY39_RS22440	COG0583	DNA-binding transcription factor activity
GPY39_RS22455	COG1414	Transcriptional regulator
GPY39_RS22460	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS22470	COG1917	Cupin 2, conserved barrel domain protein
GPY39_RS22485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY39_RS22490	COG0800	Aldolase
GPY39_RS22510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY39_RS22515	COG0823	Involved in the tonB-independent uptake of proteins
GPY39_RS22520	COG2375	cellular response to nickel ion
GPY39_RS22550	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY39_RS22555	COG3047	cAMP biosynthetic process
GPY39_RS22585	COG3408	Glycogen debranching enzyme
GPY39_RS22585	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY39_RS22590	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GPY39_RS22600	COG0583	DNA-binding transcription factor activity
GPY39_RS22610	COG0583	DNA-binding transcription factor activity
GPY39_RS22625	COG0546	phosphoglycolate phosphatase activity
GPY39_RS22650	COG3835	regulator
GPY39_RS22655	COG2610	gluconate transmembrane transporter activity
GPY39_RS22660	COG1929	Belongs to the glycerate kinase type-1 family
GPY39_RS22665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY39_RS22685	COG0456	acetyltransferase
GPY39_RS22700	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS22710	COG3005	denitrification pathway
GPY39_RS22715	COG0243	molybdopterin cofactor binding
GPY39_RS22725	COG0352	thiamine-phosphate diphosphorylase activity
GPY39_RS22730	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY39_RS22735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY39_RS22740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY39_RS22745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY39_RS22750	COG1116	anion transmembrane transporter activity
GPY39_RS22755	COG0351	phosphomethylpyrimidine kinase
GPY39_RS22765	COG0312	modulator of DNA gyrase
GPY39_RS22770	COG0312	modulator of DNA gyrase
GPY39_RS22775	COG1901	pseudouridine methyltransferase
GPY39_RS22835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY39_RS22845	COG0584	glycerophosphoryl diester phosphodiesterase
GPY39_RS22855	COG0745	RESPONSE REGULATOR receiver
GPY39_RS22875	COG0811	peptide transport
GPY39_RS22880	COG0811	peptide transport
GPY39_RS22885	COG0848	biopolymer transport protein
GPY39_RS22930	COG1121	(ABC) transporter
GPY39_RS22935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY39_RS22950	COG1770	oligopeptidase
GPY39_RS22955	COG2814	Major facilitator Superfamily
GPY39_RS22960	COG0010	Belongs to the arginase family
GPY39_RS22965	COG1166	arginine decarboxylase activity
GPY39_RS22975	COG0189	ligase activity
GPY39_RS22975	COG4067	protein conserved in archaea
GPY39_RS22980	COG0189	ligase activity
GPY39_RS22990	COG0583	DNA-binding transcription factor activity
GPY39_RS23035	COG3706	GGDEF domain
GPY39_RS23065	COG0579	oxidoreductase
GPY39_RS23075	COG3033	Beta-eliminating lyase
GPY39_RS23095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY39_RS23105	COG3145	DNA-N1-methyladenine dioxygenase activity
GPY39_RS23110	COG3706	GGDEF domain
GPY39_RS23115	COG0840	transmembrane signaling receptor activity
GPY39_RS23130	COG3706	GGDEF domain
GPY39_RS23135	COG0415	Belongs to the DNA photolyase family
GPY39_RS23140	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY39_RS23155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY39_RS23155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY39_RS23160	COG1765	OsmC-like protein
GPY39_RS23165	COG0110	maltose O-acetyltransferase activity
GPY39_RS23205	COG1011	Hydrolase
GPY39_RS23220	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY39_RS23230	COG2067	long-chain fatty acid transport protein
GPY39_RS23235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS23240	COG1136	(ABC) transporter
GPY39_RS23240	COG0577	efflux transmembrane transporter activity
GPY39_RS23250	COG3240	lipase activity
GPY39_RS23280	COG1609	Transcriptional regulator
GPY39_RS23285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY39_RS23300	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY39_RS23310	COG3842	ATPase activity
GPY39_RS23335	COG2990	Protein conserved in bacteria
GPY39_RS23350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY39_RS23355	COG2866	Carboxypeptidase
GPY39_RS23370	COG0583	DNA-binding transcription factor activity
GPY39_RS23395	COG1760	l-serine dehydratase
GPY39_RS23415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY39_RS23425	COG0741	lytic transglycosylase activity
GPY39_RS23445	COG1815	bacterial-type flagellum-dependent cell motility
GPY39_RS23450	COG1558	bacterial-type flagellum-dependent cell motility
GPY39_RS23455	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY39_RS23460	COG1749	Flagellar hook protein flgE
GPY39_RS23465	COG4787	bacterial-type flagellum-dependent cell motility
GPY39_RS23470	COG4786	Flagellar basal body rod
GPY39_RS23475	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY39_RS23480	COG1706	bacterial-type flagellum-dependent cell motility
GPY39_RS23490	COG4786	Flagellar basal body rod
GPY39_RS23490	COG1256	bacterial-type flagellum assembly
GPY39_RS23495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY39_RS23515	COG1304	FMN binding
GPY39_RS23545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY39_RS23555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY39_RS23560	COG0459	protein refolding
GPY39_RS23575	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS23595	COG1309	transcriptional regulator
GPY39_RS23605	COG0737	Belongs to the 5'-nucleotidase family
GPY39_RS23610	COG2070	2-Nitropropane dioxygenase
GPY39_RS23615	COG3537	Alpha-1,2-mannosidase
GPY39_RS23620	COG3537	Alpha-1,2-mannosidase
GPY39_RS23630	COG3537	Alpha-1,2-mannosidase
GPY39_RS23635	COG3537	Alpha-1,2-mannosidase
GPY39_RS23640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY39_RS23650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY39_RS23650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY39_RS23655	COG0346	lactoylglutathione lyase activity
GPY39_RS23660	COG1349	DNA-binding transcription factor activity
GPY39_RS23685	COG1335	isochorismatase
GPY39_RS23695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY39_RS23725	COG0583	DNA-binding transcription factor activity
GPY39_RS23740	COG3713	MltA-interacting MipA family protein
GPY39_RS23750	COG3015	lipoprotein NlpE involved in copper resistance
GPY39_RS23760	COG1342	Belongs to the UPF0251 family
GPY39_RS23785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY39_RS23795	COG4948	Mandelate Racemase Muconate Lactonizing
GPY39_RS23805	COG0583	DNA-binding transcription factor activity
GPY39_RS23855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY39_RS23905	COG3842	ATPase activity
GPY39_RS23935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY39_RS23955	COG3706	GGDEF domain
GPY39_RS23975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY39_RS23990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY39_RS23995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY39_RS24015	COG0574	Belongs to the PEP-utilizing enzyme family
GPY39_RS24015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY39_RS24020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY39_RS24025	COG0252	asparaginase activity
GPY39_RS24035	COG0583	DNA-binding transcription factor activity
GPY39_RS24050	COG3122	Protein conserved in bacteria
GPY39_RS24065	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS24075	COG1063	alcohol dehydrogenase
GPY39_RS24080	COG1902	pentaerythritol trinitrate reductase activity
GPY39_RS24095	COG0583	DNA-binding transcription factor activity
GPY39_RS24105	COG0513	Belongs to the DEAD box helicase family
GPY39_RS24135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY39_RS24140	COG2207	Transcriptional regulator
GPY39_RS24140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY39_RS24160	COG3746	phosphate-selective porin O and P
GPY39_RS24180	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS24200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY39_RS24210	COG0625	glutathione transferase activity
GPY39_RS24220	COG1686	Belongs to the peptidase S11 family
GPY39_RS24245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY39_RS24265	COG1278	Cold shock
GPY39_RS24270	COG1741	Belongs to the pirin family
GPY39_RS24275	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY39_RS24285	COG1846	Transcriptional regulator
GPY39_RS24300	COG2814	Major facilitator Superfamily
GPY39_RS24310	COG0673	inositol 2-dehydrogenase activity
GPY39_RS24315	COG2194	sulfuric ester hydrolase activity
GPY39_RS24320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY39_RS24330	COG2205	protein histidine kinase activity
GPY39_RS24335	COG0745	RESPONSE REGULATOR receiver
GPY39_RS24340	COG4221	oxidoreductase activity
GPY39_RS24360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY39_RS24380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY39_RS24390	COG2814	Major facilitator Superfamily
GPY39_RS24405	COG1418	mRNA catabolic process
GPY39_RS24415	COG0402	S-adenosylhomocysteine deaminase activity
GPY39_RS24420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY39_RS24430	COG2239	Acts as a magnesium transporter
GPY39_RS24435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY39_RS24450	COG0531	amino acid
GPY39_RS24460	COG1522	sequence-specific DNA binding
GPY39_RS24485	COG5002	protein histidine kinase activity
GPY39_RS24485	COG2205	protein histidine kinase activity
GPY39_RS24485	COG0784	Response regulator, receiver
GPY39_RS24490	COG0673	inositol 2-dehydrogenase activity
GPY39_RS24495	COG0534	Mate efflux family protein
GPY39_RS24500	COG2926	Belongs to the UPF0265 family
GPY39_RS24515	COG3132	Protein of unknown function, DUF480
GPY39_RS24520	COG2827	Endonuclease containing a URI domain
GPY39_RS24525	COG1879	ABC-type sugar transport system periplasmic component
GPY39_RS24530	COG0784	Response regulator, receiver
GPY39_RS24530	COG2205	protein histidine kinase activity
GPY39_RS24540	COG1566	PFAM secretion protein HlyD family protein
GPY39_RS24560	COG1522	sequence-specific DNA binding
GPY39_RS24585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY39_RS24590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY39_RS24600	COG1280	lysine exporter protein (LysE YggA)
GPY39_RS24610	COG0183	Belongs to the thiolase family
GPY39_RS24630	COG3005	denitrification pathway
GPY39_RS24640	COG0243	molybdopterin cofactor binding
GPY39_RS24650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY39_RS24655	COG3850	Histidine kinase
GPY39_RS24660	COG2197	response regulator
GPY39_RS24675	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY39_RS24695	COG0840	transmembrane signaling receptor activity
GPY39_RS24705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY39_RS24715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY39_RS24720	COG2814	Major facilitator Superfamily
GPY39_RS24730	COG0840	transmembrane signaling receptor activity
GPY39_RS24735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY39_RS24740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY39_RS24765	COG2897	thiosulfate sulfurtransferase activity
GPY39_RS24785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY39_RS24795	COG0302	gtp cyclohydrolase
GPY39_RS24800	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY39_RS24810	COG0038	chloride channel
GPY39_RS24825	COG4989	oxidoreductase activity
GPY39_RS24840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY39_RS24840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY39_RS24845	COG0516	GMP reductase activity
GPY39_RS24850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY39_RS24920	COG3474	cytochrome
GPY39_RS24930	COG0789	Transcriptional regulator
GPY39_RS24935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY39_RS24940	COG0384	phenazine biosynthesis protein PhzF
GPY39_RS24950	COG1294	oxidase, subunit
GPY39_RS24955	COG1271	oxidase subunit
GPY39_RS24960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY39_RS24965	COG0110	maltose O-acetyltransferase activity
GPY39_RS24975	COG3264	Mechanosensitive ion channel
GPY39_RS24975	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY39_RS24990	COG2205	protein histidine kinase activity
GPY39_RS24990	COG3437	response regulator, receiver
GPY39_RS24990	COG3850	Histidine kinase
GPY39_RS24990	COG4999	Histidine kinase
GPY39_RS25000	COG0439	Biotin carboxylase
GPY39_RS25010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY39_RS25015	COG1960	acyl-CoA dehydrogenase activity
GPY39_RS25025	COG0183	Belongs to the thiolase family
GPY39_RS25035	COG1960	acyl-CoA dehydrogenase activity
GPY39_RS25040	COG1024	Enoyl-CoA hydratase
GPY39_RS25055	COG1028	Short-chain dehydrogenase reductase Sdr
GPY39_RS25065	COG3706	GGDEF domain
GPY39_RS25070	COG1309	transcriptional regulator
GPY39_RS25075	COG1012	belongs to the aldehyde dehydrogenase family
GPY39_RS25090	COG4176	ABC-type proline glycine betaine transport system permease component
GPY39_RS25095	COG0517	IMP dehydrogenase activity
GPY39_RS25095	COG4175	Glycine betaine
GPY39_RS25110	COG0330	HflC and HflK could
GPY39_RS25120	COG5001	Diguanylate cyclase
GPY39_RS25120	COG3300	MHYT domain
GPY39_RS25140	COG2205	protein histidine kinase activity
GPY39_RS25140	COG0784	Response regulator, receiver
GPY39_RS25200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY39_RS25205	COG5001	Diguanylate cyclase
GPY39_RS25210	COG1869	D-ribose catabolic process
GPY39_RS25215	COG1129	ABC transporter
GPY39_RS25220	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY39_RS25225	COG1879	ABC-type sugar transport system periplasmic component
GPY39_RS25230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY39_RS25235	COG1609	Transcriptional regulator
GPY39_RS25250	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY39_RS25260	COG4607	ABC-type enterochelin transport system periplasmic component
GPY39_RS25265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY39_RS25270	COG4605	iron ion homeostasis
GPY39_RS25275	COG4604	ABC transporter, ATP-binding protein
GPY39_RS25280	COG0789	Transcriptional regulator
GPY39_RS25295	COG4206	TonB-dependent receptor
GPY39_RS25330	COG1289	transmembrane transporter activity
GPY39_RS25335	COG0210	DNA helicase
GPY39_RS25340	COG1803	Methylglyoxal synthase
GPY39_RS25345	COG1879	ABC-type sugar transport system periplasmic component
GPY39_RS25350	COG2205	protein histidine kinase activity
GPY39_RS25350	COG2198	Histidine kinase
GPY39_RS25350	COG0784	Response regulator, receiver
GPY39_RS25365	COG0745	RESPONSE REGULATOR receiver
GPY39_RS25370	COG3119	arylsulfatase activity
GPY39_RS25375	COG3119	arylsulfatase activity
GPY39_RS25390	COG3119	arylsulfatase activity
GPY39_RS25395	COG0641	radical SAM
GPY39_RS25400	COG0714	Associated with various cellular activities
GPY39_RS25430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY39_RS25435	COG0583	DNA-binding transcription factor activity
GPY39_RS25440	COG1597	lipid kinase activity
GPY39_RS25445	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY39_RS25465	COG0641	radical SAM
GPY39_RS25495	COG0501	Belongs to the peptidase M48B family
GPY39_RS25500	COG1704	LemA family
GPY39_RS25505	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY39_RS25535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY39_RS25555	COG2207	Transcriptional regulator
GPY39_RS25580	COG4964	Belongs to the GSP D family
GPY39_RS25640	COG0583	DNA-binding transcription factor activity
GPY39_RS25645	COG0583	DNA-binding transcription factor activity
GPY39_RS25660	COG5001	Diguanylate cyclase
GPY39_RS25660	COG3300	MHYT domain
GPY39_RS25665	COG2197	response regulator
GPY39_RS25670	COG3706	GGDEF domain
GPY39_RS25680	COG2197	response regulator
GPY39_RS25705	COG0784	Response regulator, receiver
GPY39_RS25705	COG0835	chemotaxis
GPY39_RS25725	COG2962	Rard protein
GPY39_RS25740	COG0671	phosphoesterase, PA-phosphatase related
GPY39_RS25750	COG3227	Zinc metalloprotease (Elastase)
GPY39_RS25755	COG2076	Multidrug Resistance protein
GPY39_RS25785	COG0471	metal ion transport
GPY39_RS25790	COG3290	protein histidine kinase activity
GPY39_RS25795	COG4565	transcriptional regulatory protein
GPY39_RS25805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY39_RS25805	COG0069	glutamate synthase activity
GPY39_RS25815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY39_RS25840	COG1902	pentaerythritol trinitrate reductase activity
GPY39_RS25845	COG0346	lactoylglutathione lyase activity
GPY39_RS25865	COG2239	Acts as a magnesium transporter
GPY39_RS25885	COG0242	peptide deformylase activity
GPY39_RS25930	COG2176	DNA-directed DNA polymerase activity
GPY39_RS25935	COG0583	DNA-binding transcription factor activity
GPY39_RS25940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY39_RS26005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY39_RS26015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY39_RS26015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY39_RS26020	COG0509	glycine decarboxylation via glycine cleavage system
GPY39_RS26025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY39_RS26065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY39_RS26065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY39_RS26065	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY39_RS26070	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY39_RS26075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY39_RS26075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY39_RS26080	COG1609	Transcriptional regulator
GPY39_RS26100	COG2200	EAL domain
GPY39_RS26100	COG2203	Gaf domain
GPY39_RS26100	COG2199	diguanylate cyclase activity
GPY39_RS26105	COG0765	amino acid transport
GPY39_RS26110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY39_RS26115	COG0765	amino acid transport
GPY39_RS26120	COG1126	abc transporter atp-binding protein
GPY39_RS26125	COG0469	pyruvate kinase activity
GPY39_RS26130	COG2271	Major facilitator Superfamily
GPY39_RS26135	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY39_RS26155	COG1979	alcohol dehydrogenase
GPY39_RS26160	COG2207	Transcriptional regulator