locus-tag	class	description
EHC66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHC66_RS00010	COG0592	DNA-directed DNA polymerase activity
EHC66_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EHC66_RS00020	COG0187	DNA topoisomerase II activity
EHC66_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
EHC66_RS00045	COG3977	Valine--pyruvate aminotransferase
EHC66_RS00050	COG0366	Alpha amylase catalytic
EHC66_RS00055	COG0751	glycine-tRNA ligase activity
EHC66_RS00060	COG0752	glycyl-tRNA synthetase alpha subunit
EHC66_RS00065	COG2119	membrane
EHC66_RS00075	COG0425	Belongs to the sulfur carrier protein TusA family
EHC66_RS00090	COG0604	alcohol dehydrogenase
EHC66_RS00095	COG0183	Belongs to the thiolase family
EHC66_RS00100	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHC66_RS00100	COG1024	Enoyl-CoA hydratase
EHC66_RS00105	COG1739	Uncharacterized protein family UPF0029
EHC66_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHC66_RS00170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EHC66_RS00175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EHC66_RS00180	COG0352	thiamine-phosphate diphosphorylase activity
EHC66_RS00185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EHC66_RS00190	COG2104	thiamine diphosphate biosynthetic process
EHC66_RS00195	COG2022	thiamine diphosphate biosynthetic process
EHC66_RS00205	COG0006	proline dipeptidase activity
EHC66_RS00205	COG0006	proline dipeptidase activity
EHC66_RS00235	COG3220	belongs to the UPF0276 family
EHC66_RS00245	COG0210	DNA helicase
EHC66_RS00255	COG0405	Gamma-glutamyltransferase
EHC66_RS00260	COG1280	lysine exporter protein (LysE YggA)
EHC66_RS00270	COG2962	Rard protein
EHC66_RS00275	COG0514	ATP-dependent DNA helicase (RecQ)
EHC66_RS00290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EHC66_RS00295	COG0248	Ppx GppA phosphatase
EHC66_RS00300	COG0513	Belongs to the DEAD box helicase family
EHC66_RS00305	COG3118	belongs to the thioredoxin family
EHC66_RS00310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EHC66_RS00325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EHC66_RS00330	COG0633	Ferredoxin
EHC66_RS00380	COG3071	HemY protein
EHC66_RS00385	COG2959	enzyme of heme biosynthesis
EHC66_RS00390	COG1587	Uroporphyrinogen-III synthase
EHC66_RS00395	COG0181	hydroxymethylbilane synthase activity
EHC66_RS00400	COG3072	Adenylate cyclase
EHC66_RS00405	COG1965	Belongs to the frataxin family
EHC66_RS00415	COG0019	diaminopimelate decarboxylase activity
EHC66_RS00420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EHC66_RS00430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHC66_RS00435	COG1011	Hydrolase
EHC66_RS00440	COG2199	diguanylate cyclase activity
EHC66_RS00440	COG2200	EAL domain
EHC66_RS00440	COG3287	FIST C domain
EHC66_RS00460	COG0561	phosphatase activity
EHC66_RS00465	COG2267	carboxylic ester hydrolase activity
EHC66_RS00470	COG1280	lysine exporter protein (LysE YggA)
EHC66_RS00475	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EHC66_RS00480	COG0640	Transcriptional regulator
EHC66_RS00485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHC66_RS00540	COG2095	MarC family integral membrane protein
EHC66_RS00550	COG0742	ribosomal rna small subunit methyltransferase
EHC66_RS00555	COG0552	protein localization to endoplasmic reticulum
EHC66_RS00555	COG0552	protein localization to endoplasmic reticulum
EHC66_RS00560	COG2884	Cell division ATP-binding protein ftsE
EHC66_RS00565	COG2177	Part of the ABC transporter FtsEX involved in
EHC66_RS00575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHC66_RS00580	COG0705	Rhomboid family
EHC66_RS00585	COG1580	Controls the rotational direction of flagella during chemotaxis
EHC66_RS00590	COG3161	chorismate lyase activity
EHC66_RS00595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EHC66_RS00600	COG2937	Belongs to the GPAT DAPAT family
EHC66_RS00610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EHC66_RS00615	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EHC66_RS00620	COG0534	Mate efflux family protein
EHC66_RS00625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHC66_RS00680	COG2003	Belongs to the UPF0758 family
EHC66_RS00695	COG3339	Conserved Protein
EHC66_RS00750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHC66_RS00755	COG4206	TonB-dependent receptor
EHC66_RS00765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EHC66_RS00830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHC66_RS00840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EHC66_RS00875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHC66_RS00885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EHC66_RS00890	COG0250	Participates in transcription elongation, termination and antitermination
EHC66_RS00895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EHC66_RS00900	COG0081	regulation of translation
EHC66_RS00905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EHC66_RS00910	COG0222	ribosome binding
EHC66_RS00915	COG0085	RNA polymerase activity
EHC66_RS00920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EHC66_RS00925	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EHC66_RS00930	COG2816	NAD+ diphosphatase activity
EHC66_RS00945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EHC66_RS00950	COG1573	uracil-dna glycosylase
EHC66_RS00955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHC66_RS00960	COG3068	Protein conserved in bacteria
EHC66_RS00965	COG1253	flavin adenine dinucleotide binding
EHC66_RS00980	COG0151	Belongs to the GarS family
EHC66_RS00990	COG0138	bifunctional purine biosynthesis protein purh
EHC66_RS01000	COG0789	Transcriptional regulator
EHC66_RS01005	COG3710	Transcriptional regulator
EHC66_RS01015	COG0531	amino acid
EHC66_RS01020	COG1982	Orn Lys Arg decarboxylase major
EHC66_RS01085	COG3706	GGDEF domain
EHC66_RS01090	COG0488	(ABC) transporter
EHC66_RS01100	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EHC66_RS01105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHC66_RS01110	COG2264	protein methyltransferase activity
EHC66_RS01120	COG0439	Biotin carboxylase
EHC66_RS01125	COG0511	ligase activity, forming carbon-carbon bonds
EHC66_RS01130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHC66_RS01135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHC66_RS01150	COG2814	Major facilitator Superfamily
EHC66_RS01155	COG0784	Response regulator, receiver
EHC66_RS01155	COG2205	protein histidine kinase activity
EHC66_RS01155	COG2198	Histidine kinase
EHC66_RS01180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHC66_RS01190	COG3263	regulation of cellular component size
EHC66_RS01200	COG4232	protein-disulfide reductase activity
EHC66_RS01205	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EHC66_RS01210	COG1027	Aspartate ammonia-lyase
EHC66_RS01215	COG3030	protein affecting phage T7 exclusion by the F plasmid
EHC66_RS01220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EHC66_RS01230	COG2205	protein histidine kinase activity
EHC66_RS01235	COG0745	RESPONSE REGULATOR receiver
EHC66_RS01240	COG3678	ATP-independent chaperone mediated protein folding
EHC66_RS01250	COG0205	6-phosphofructokinase activity
EHC66_RS01255	COG0534	Mate efflux family protein
EHC66_RS01260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHC66_RS01265	COG0459	protein refolding
EHC66_RS01280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHC66_RS01290	COG1509	lysine 2,3-aminomutase activity
EHC66_RS01295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHC66_RS01305	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EHC66_RS01310	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EHC66_RS01315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHC66_RS01320	COG1053	succinate dehydrogenase
EHC66_RS01330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EHC66_RS01350	COG4942	peptidase
EHC66_RS01355	COG1045	serine acetyltransferase
EHC66_RS01360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EHC66_RS01365	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EHC66_RS01370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHC66_RS01375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EHC66_RS01390	COG0471	metal ion transport
EHC66_RS01395	COG0688	phosphatidylethanolamine metabolic process
EHC66_RS01400	COG1162	GTPase activity
EHC66_RS01405	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EHC66_RS01475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EHC66_RS01480	COG0802	atpase or kinase
EHC66_RS01485	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHC66_RS01490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EHC66_RS01495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EHC66_RS01505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EHC66_RS01510	COG0330	HflC and HflK could
EHC66_RS01515	COG0330	HflC and HflK could
EHC66_RS01520	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EHC66_RS01525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EHC66_RS01535	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EHC66_RS01540	COG1017	nitric oxide dioxygenase activity
EHC66_RS01540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHC66_RS01545	COG1959	2 iron, 2 sulfur cluster binding
EHC66_RS01550	COG0557	exoribonuclease II activity
EHC66_RS01555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHC66_RS01560	COG0546	phosphoglycolate phosphatase activity
EHC66_RS01565	COG0180	Tryptophanyl-tRNA synthetase
EHC66_RS01595	COG0512	Glutamine amidotransferase of anthranilate synthase
EHC66_RS01600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EHC66_RS01610	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_RS01620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHC66_RS01625	COG3954	Phosphoribulokinase
EHC66_RS01630	COG3089	Belongs to the UPF0270 family
EHC66_RS01635	COG0429	hydrolase of the alpha beta-hydrolase fold
EHC66_RS01645	COG0488	(ABC) transporter
EHC66_RS01655	COG2249	NAD(P)H dehydrogenase (quinone) activity
EHC66_RS01670	COG1047	Peptidyl-prolyl cis-trans
EHC66_RS01680	COG1446	asparaginase
EHC66_RS01685	COG2900	Belongs to the SlyX family
EHC66_RS01695	COG0545	Peptidyl-prolyl cis-trans isomerase
EHC66_RS01700	COG2964	Protein conserved in bacteria
EHC66_RS01705	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EHC66_RS01710	COG2923	Belongs to the DsrF TusC family
EHC66_RS01715	COG2168	tRNA wobble position uridine thiolation
EHC66_RS01725	COG0049	tRNA binding
EHC66_RS01730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHC66_RS01735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHC66_RS01740	COG2906	2 iron, 2 sulfur cluster binding
EHC66_RS01750	COG0281	malic enzyme
EHC66_RS01760	COG0626	cystathionine gamma-synthase activity
EHC66_RS01765	COG0527	aspartate kinase activity
EHC66_RS01765	COG0460	homoserine dehydrogenase
EHC66_RS01770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EHC66_RS01780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EHC66_RS01785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHC66_RS01790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EHC66_RS01795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHC66_RS01800	COG0137	argininosuccinate synthase activity
EHC66_RS01805	COG0165	Argininosuccinate lyase
EHC66_RS01805	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EHC66_RS01820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHC66_RS01820	COG0678	peroxiredoxin activity
EHC66_RS01830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EHC66_RS01860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHC66_RS01865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EHC66_RS01875	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EHC66_RS01880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EHC66_RS01885	COG0360	Binds together with S18 to 16S ribosomal RNA
EHC66_RS01890	COG2965	DNA replication, synthesis of RNA primer
EHC66_RS01900	COG0359	binds to the 23S rRNA
EHC66_RS01910	COG0305	Participates in initiation and elongation during chromosome replication
EHC66_RS01915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHC66_RS01925	COG0432	Pfam Uncharacterised protein family UPF0047
EHC66_RS01930	COG0166	Belongs to the GPI family
EHC66_RS01940	COG0735	belongs to the Fur family
EHC66_RS01950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHC66_RS01975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EHC66_RS01980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHC66_RS01985	COG0175	sulfate reduction
EHC66_RS02030	COG0646	methionine synthase
EHC66_RS02030	COG1410	methionine synthase
EHC66_RS02035	COG0527	aspartate kinase activity
EHC66_RS02040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EHC66_RS02050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EHC66_RS02065	COG0629	single-stranded DNA binding
EHC66_RS02070	COG2200	EAL domain
EHC66_RS02070	COG2199	diguanylate cyclase activity
EHC66_RS02095	COG3409	Peptidoglycan-binding domain 1 protein
EHC66_RS02095	COG3267	Type II secretory pathway component ExeA
EHC66_RS02105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHC66_RS02110	COG1459	type II secretion system
EHC66_RS02155	COG1077	Cell shape determining protein MreB Mrl
EHC66_RS02160	COG1792	Involved in formation and maintenance of cell shape
EHC66_RS02165	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EHC66_RS02170	COG0424	maF-like protein
EHC66_RS02175	COG1530	ribonuclease E activity
EHC66_RS02180	COG3164	Protein of unknown function
EHC66_RS02185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHC66_RS02190	COG0312	modulator of DNA gyrase
EHC66_RS02195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EHC66_RS02200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHC66_RS02215	COG0564	pseudouridine synthase activity
EHC66_RS02220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHC66_RS02225	COG3028	Belongs to the UPF0307 family
EHC66_RS02230	COG0312	modulator of DNA gyrase
EHC66_RS02235	COG2239	Acts as a magnesium transporter
EHC66_RS02240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS02245	COG1660	Displays ATPase and GTPase activities
EHC66_RS02250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS02255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHC66_RS02265	COG1137	ATPase activity
EHC66_RS02270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EHC66_RS02280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EHC66_RS02280	COG0517	IMP dehydrogenase activity
EHC66_RS02290	COG1127	ABC transporter
EHC66_RS02295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHC66_RS02300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHC66_RS02305	COG2854	intermembrane phospholipid transfer
EHC66_RS02315	COG5007	Belongs to the BolA IbaG family
EHC66_RS02320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EHC66_RS02325	COG0204	Acyl-transferase
EHC66_RS02330	COG0251	oxidation-reduction process
EHC66_RS02335	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EHC66_RS02340	COG0540	Belongs to the ATCase OTCase family
EHC66_RS02350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EHC66_RS02355	COG2235	arginine
EHC66_RS02385	COG0525	valine-tRNA ligase activity
EHC66_RS02390	COG2927	DNA polymerase III (CHI subunit)
EHC66_RS02395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHC66_RS02400	COG0795	lipopolysaccharide-transporting ATPase activity
EHC66_RS02405	COG0795	lipopolysaccharide-transporting ATPase activity
EHC66_RS02415	COG4325	translation initiation factor activity
EHC66_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS02430	COG0726	polysaccharide deacetylase
EHC66_RS02435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EHC66_RS02440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EHC66_RS02445	COG1447	Phosphotransferase system cellobiose-specific component IIA
EHC66_RS02450	COG1486	melibiose metabolic process
EHC66_RS02455	COG3394	polysaccharide catabolic process
EHC66_RS02465	COG3437	response regulator, receiver
EHC66_RS02515	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_RS02545	COG0840	transmembrane signaling receptor activity
EHC66_RS02585	COG0741	lytic transglycosylase activity
EHC66_RS02590	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EHC66_RS02600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EHC66_RS02610	COG2066	Belongs to the glutaminase family
EHC66_RS02615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHC66_RS02620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EHC66_RS02630	COG1872	DUF167
EHC66_RS02635	COG0762	integral membrane protein
EHC66_RS02640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EHC66_RS02645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EHC66_RS02660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EHC66_RS02665	COG1678	Uncharacterized ACR, COG1678
EHC66_RS02670	COG0189	ligase activity
EHC66_RS02675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EHC66_RS02680	COG2356	endonuclease I
EHC66_RS02685	COG3091	SprT-like family
EHC66_RS02695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EHC66_RS02705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHC66_RS02710	COG0583	DNA-binding transcription factor activity
EHC66_RS02715	COG4771	TonB-dependent receptor
EHC66_RS02720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHC66_RS02725	COG0126	phosphoglycerate kinase activity
EHC66_RS02730	COG0191	fructose-bisphosphate aldolase activity
EHC66_RS02735	COG0668	transmembrane transport
EHC66_RS02740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EHC66_RS02750	COG0583	DNA-binding transcription factor activity
EHC66_RS02760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHC66_RS02765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EHC66_RS02770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EHC66_RS02780	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EHC66_RS02790	COG3079	Belongs to the UPF0149 family
EHC66_RS02795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHC66_RS02800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHC66_RS02815	COG0354	folic acid binding
EHC66_RS02820	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EHC66_RS02830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EHC66_RS02840	COG1595	DNA-templated transcription, initiation
EHC66_RS02845	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
EHC66_RS02855	COG3086	response to oxidative stress
EHC66_RS02860	COG0481	GTPase activity
EHC66_RS02865	COG0681	Belongs to the peptidase S26 family
EHC66_RS02870	COG0571	ribonuclease III activity
EHC66_RS02875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EHC66_RS02880	COG1381	Involved in DNA repair and RecF pathway recombination
EHC66_RS02885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EHC66_RS02890	COG0736	holo-[acyl-carrier-protein] synthase activity
EHC66_RS02900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHC66_RS02910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHC66_RS02915	COG3956	TIGRFAM MazG family protein
EHC66_RS02920	COG0504	CTP synthase activity
EHC66_RS02925	COG0148	phosphopyruvate hydratase activity
EHC66_RS02930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EHC66_RS02935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHC66_RS02940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EHC66_RS02945	COG0585	pseudouridine synthase activity
EHC66_RS02950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EHC66_RS02955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EHC66_RS02970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EHC66_RS02975	COG0582	viral genome integration into host DNA
EHC66_RS02980	COG3335	DDE superfamily endonuclease
EHC66_RS03005	COG2826	transposase and inactivated derivatives, IS30 family
EHC66_RS03030	COG2003	Belongs to the UPF0758 family
EHC66_RS03075	COG3501	Rhs element vgr protein
EHC66_RS03100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EHC66_RS03120	COG1546	Belongs to the CinA family
EHC66_RS03125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EHC66_RS03130	COG2137	regulation of response to DNA damage stimulus
EHC66_RS03135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHC66_RS03140	COG0527	aspartate kinase activity
EHC66_RS03200	COG3630	sodium ion export across plasma membrane
EHC66_RS03205	COG0511	ligase activity, forming carbon-carbon bonds
EHC66_RS03205	COG5016	pyruvate
EHC66_RS03210	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EHC66_RS03215	COG1063	alcohol dehydrogenase
EHC66_RS03220	COG1238	metal cluster binding
EHC66_RS03225	COG0612	Peptidase, M16
EHC66_RS03230	COG2918	glutathione biosynthetic process
EHC66_RS03240	COG1854	S-ribosylhomocysteine lyase activity
EHC66_RS03245	COG4536	flavin adenine dinucleotide binding
EHC66_RS03250	COG4137	Cytochrome C assembly protein
EHC66_RS03255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EHC66_RS03260	COG0228	four-way junction DNA binding
EHC66_RS03265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EHC66_RS03270	COG0336	Belongs to the RNA methyltransferase TrmD family
EHC66_RS03275	COG0335	large ribosomal subunit rRNA binding
EHC66_RS03280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EHC66_RS03285	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EHC66_RS03290	COG0237	dephospho-CoA kinase activity
EHC66_RS03300	COG1459	type II secretion system
EHC66_RS03305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHC66_RS03315	COG0157	Belongs to the NadC ModD family
EHC66_RS03325	COG2186	Transcriptional regulator
EHC66_RS03330	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EHC66_RS03335	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHC66_RS03340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHC66_RS03355	COG0288	reversible hydration of carbon dioxide
EHC66_RS03360	COG0659	secondary active sulfate transmembrane transporter activity
EHC66_RS03370	COG1131	(ABC) transporter
EHC66_RS03375	COG0842	Transport permease protein
EHC66_RS03380	COG1560	Kdo2-lipid A biosynthetic process
EHC66_RS03390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EHC66_RS03395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EHC66_RS03400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EHC66_RS03415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHC66_RS03425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EHC66_RS03430	COG1489	DNA binding
EHC66_RS03435	COG1643	Atp-dependent helicase
EHC66_RS03440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHC66_RS03445	COG1752	Esterase of the alpha-beta hydrolase superfamily
EHC66_RS03450	COG1049	propionate catabolic process, 2-methylcitrate cycle
EHC66_RS03455	COG3112	Uncharacterised protein family (UPF0231)
EHC66_RS03465	COG0004	ammonium transporteR
EHC66_RS03470	COG1840	ABC-type Fe3 transport system, periplasmic component
EHC66_RS03480	COG3842	ATPase activity
EHC66_RS03485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHC66_RS03500	COG2971	BadF BadG BcrA BcrD
EHC66_RS03510	COG4608	Belongs to the ABC transporter superfamily
EHC66_RS03515	COG0444	Belongs to the ABC transporter superfamily
EHC66_RS03520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHC66_RS03530	COG0747	negative chemotaxis
EHC66_RS03535	COG2198	Histidine kinase
EHC66_RS03535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_RS03535	COG0784	Response regulator, receiver
EHC66_RS03535	COG2205	protein histidine kinase activity
EHC66_RS03540	COG2813	Specifically methylates the guanine in position
EHC66_RS03545	COG0628	permease
EHC66_RS03550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EHC66_RS03555	COG0316	Belongs to the HesB IscA family
EHC66_RS03565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_RS03570	COG0739	heme binding
EHC66_RS03575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EHC66_RS03585	COG2027	D-alanyl-D-alanine carboxypeptidase
EHC66_RS03590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHC66_RS03595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHC66_RS03600	COG1534	Rna-binding protein
EHC66_RS03605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EHC66_RS03610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHC66_RS03615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EHC66_RS03620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHC66_RS03630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EHC66_RS03645	COG0779	Required for maturation of 30S ribosomal subunits
EHC66_RS03650	COG0195	Participates in both transcription termination and antitermination
EHC66_RS03655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EHC66_RS03660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EHC66_RS03665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EHC66_RS03670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EHC66_RS03675	COG1185	polyribonucleotide nucleotidyltransferase activity
EHC66_RS03690	COG0534	Mate efflux family protein
EHC66_RS03715	COG3153	acetyltransferase
EHC66_RS03735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EHC66_RS03745	COG0084	hydrolase, TatD family'
EHC66_RS03750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHC66_RS03755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EHC66_RS03760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EHC66_RS03765	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EHC66_RS03770	COG0813	purine-nucleoside phosphorylase activity
EHC66_RS03780	COG0560	Phosphoserine phosphatase
EHC66_RS03790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EHC66_RS03795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHC66_RS03800	COG0583	DNA-binding transcription factor activity
EHC66_RS03810	COG1022	Amp-dependent synthetase and ligase
EHC66_RS03815	COG2169	Transcriptional regulator
EHC66_RS03840	COG4964	Belongs to the GSP D family
EHC66_RS03900	COG0583	DNA-binding transcription factor activity
EHC66_RS03905	COG0531	amino acid
EHC66_RS03910	COG2731	YhcH YjgK YiaL family protein
EHC66_RS03915	COG3250	beta-galactosidase activity
EHC66_RS03920	COG1609	Transcriptional regulator
EHC66_RS03930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EHC66_RS03940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EHC66_RS03945	COG2017	converts alpha-aldose to the beta-anomer
EHC66_RS03960	COG2211	Major facilitator Superfamily
EHC66_RS03965	COG1609	Transcriptional regulator
EHC66_RS03970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHC66_RS03985	COG0598	Magnesium transport protein CorA
EHC66_RS03990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EHC66_RS03995	COG1349	DNA-binding transcription factor activity
EHC66_RS04000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EHC66_RS04005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHC66_RS04020	COG2271	Major facilitator Superfamily
EHC66_RS04025	COG0584	glycerophosphoryl diester phosphodiesterase
EHC66_RS04030	COG2171	N-acyltransferase activity
EHC66_RS04035	COG3141	response to X-ray
EHC66_RS04055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EHC66_RS04060	COG1074	ATP-dependent DNA helicase activity
EHC66_RS04065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EHC66_RS04075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EHC66_RS04075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHC66_RS04085	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EHC66_RS04090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EHC66_RS04095	COG2166	iron-sulfur cluster assembly
EHC66_RS04100	COG3706	GGDEF domain
EHC66_RS04105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EHC66_RS04110	COG0693	protein deglycase activity
EHC66_RS04115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EHC66_RS04120	COG3248	Nucleoside-binding outer membrane protein
EHC66_RS04140	COG1595	DNA-templated transcription, initiation
EHC66_RS04160	COG3056	Lipoprotein
EHC66_RS04165	COG2813	Specifically methylates the guanine in position
EHC66_RS04170	COG0271	Belongs to the BolA IbaG family
EHC66_RS04175	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EHC66_RS04180	COG1805	sodium ion transport
EHC66_RS04185	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EHC66_RS04190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EHC66_RS04195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EHC66_RS04200	COG2871	sodium ion transport
EHC66_RS04205	COG1477	protein flavinylation
EHC66_RS04220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EHC66_RS04225	COG0514	ATP-dependent DNA helicase (RecQ)
EHC66_RS04230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHC66_RS04245	COG0733	neurotransmitter:sodium symporter activity
EHC66_RS04265	COG0442	prolyl-tRNA aminoacylation
EHC66_RS04270	COG1720	tRNA m6t6A37 methyltransferase activity
EHC66_RS04275	COG0254	rRNA binding
EHC66_RS04290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EHC66_RS04295	COG1671	Belongs to the UPF0178 family
EHC66_RS04320	COG3098	single-species biofilm formation
EHC66_RS04325	COG0564	pseudouridine synthase activity
EHC66_RS04335	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EHC66_RS04340	COG0024	Methionine aminopeptidase
EHC66_RS04345	COG0052	Belongs to the universal ribosomal protein uS2 family
EHC66_RS04350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EHC66_RS04355	COG0528	UMP kinase activity
EHC66_RS04360	COG0233	cytoplasmic translational termination
EHC66_RS04365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EHC66_RS04370	COG0575	Belongs to the CDS family
EHC66_RS04375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EHC66_RS04380	COG0750	zinc metalloprotease
EHC66_RS04390	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EHC66_RS04395	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_RS04400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHC66_RS04405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_RS04410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_RS04415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EHC66_RS04420	COG0587	DNA-directed DNA polymerase activity
EHC66_RS04425	COG0825	malonyl-CoA metabolic process
EHC66_RS04430	COG0037	tRNA processing
EHC66_RS04440	COG0347	Belongs to the P(II) protein family
EHC66_RS04445	COG3021	interspecies interaction between organisms
EHC66_RS04455	COG0741	lytic transglycosylase activity
EHC66_RS04455	COG1388	LysM domain
EHC66_RS04460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHC66_RS04465	COG2226	methyltransferase
EHC66_RS04470	COG0328	RNA-DNA hybrid ribonuclease activity
EHC66_RS04475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHC66_RS04490	COG1960	acyl-CoA dehydrogenase activity
EHC66_RS04495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHC66_RS04500	COG0121	glutamine amidotransferase
EHC66_RS04505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EHC66_RS04510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EHC66_RS04515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EHC66_RS04520	COG2233	PERMEase
EHC66_RS04540	COG1393	Belongs to the ArsC family
EHC66_RS04545	COG4783	chaperone-mediated protein folding
EHC66_RS04560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EHC66_RS04565	COG2716	regulation of RNA biosynthetic process
EHC66_RS04570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHC66_RS04590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHC66_RS04595	COG1393	Belongs to the ArsC family
EHC66_RS04625	COG2837	iron assimilation
EHC66_RS04630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS04640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS04645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS04650	COG1334	flagellar protein FlaG
EHC66_RS04655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EHC66_RS04665	COG1516	flagellar protein fliS
EHC66_RS04675	COG4191	Histidine kinase
EHC66_RS04680	COG2204	response regulator
EHC66_RS04685	COG1677	Flagellar hook-basal body complex protein FliE
EHC66_RS04695	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHC66_RS04745	COG1987	bacterial-type flagellum assembly
EHC66_RS04770	COG0455	bacterial-type flagellum organization
EHC66_RS04785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EHC66_RS04790	COG0643	Histidine kinase
EHC66_RS04790	COG2198	Histidine kinase
EHC66_RS04795	COG2201	protein-glutamate methylesterase activity
EHC66_RS04800	COG1192	Involved in chromosome partitioning
EHC66_RS04810	COG0835	chemotaxis
EHC66_RS04820	COG4133	protoheme IX ABC transporter activity
EHC66_RS04825	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHC66_RS04830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHC66_RS04835	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHC66_RS04840	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EHC66_RS04845	COG1138	Cytochrome C-type biogenesis protein
EHC66_RS04850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EHC66_RS04865	COG2853	Lipoprotein
EHC66_RS04875	COG2067	long-chain fatty acid transport protein
EHC66_RS04890	COG0183	Belongs to the thiolase family
EHC66_RS04895	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHC66_RS04895	COG1024	Enoyl-CoA hydratase
EHC66_RS04910	COG2062	phosphohistidine phosphatase, SixA
EHC66_RS04915	COG2840	Smr protein MutS2
EHC66_RS04920	COG2890	protein-(glutamine-N5) methyltransferase activity
EHC66_RS04925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EHC66_RS04930	COG2860	membrane
EHC66_RS04940	COG3101	peptidyl-lysine hydroxylation
EHC66_RS04955	COG0431	NADPH-dependent FMN reductase
EHC66_RS04960	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EHC66_RS04960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHC66_RS04965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHC66_RS04970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHC66_RS04975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EHC66_RS04985	COG0101	tRNA pseudouridine synthase activity
EHC66_RS04990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EHC66_RS04995	COG0285	dihydrofolate synthase activity
EHC66_RS05000	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EHC66_RS05005	COG1286	toxin biosynthetic process
EHC66_RS05010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EHC66_RS05015	COG0583	DNA-binding transcription factor activity
EHC66_RS05020	COG0745	RESPONSE REGULATOR receiver
EHC66_RS05030	COG2832	Protein of unknown function (DUF454)
EHC66_RS05035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EHC66_RS05045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EHC66_RS05050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EHC66_RS05055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHC66_RS05060	COG0814	amino acid
EHC66_RS05065	COG0251	oxidation-reduction process
EHC66_RS05070	COG3681	Belongs to the UPF0597 family
EHC66_RS05085	COG2261	transglycosylase associated protein
EHC66_RS05090	COG2983	Belongs to the UPF0260 family
EHC66_RS05095	COG0668	transmembrane transport
EHC66_RS05100	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EHC66_RS05105	COG0346	lactoylglutathione lyase activity
EHC66_RS05115	COG1785	Belongs to the alkaline phosphatase family
EHC66_RS05135	COG2226	methyltransferase
EHC66_RS05150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHC66_RS05155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHC66_RS05165	COG3139	Protein of unknown function (DUF1315)
EHC66_RS05170	COG0252	asparaginase activity
EHC66_RS05175	COG0616	signal peptide processing
EHC66_RS05180	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHC66_RS05180	COG1902	pentaerythritol trinitrate reductase activity
EHC66_RS05185	COG0778	Nitroreductase
EHC66_RS05190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHC66_RS05210	COG0123	including yeast histone deacetylase and acetoin utilization protein
EHC66_RS05220	COG3083	sulfuric ester hydrolase activity
EHC66_RS05225	COG3082	Protein of unknown function (DUF1414)
EHC66_RS05230	COG3081	Nucleoid-associated protein
EHC66_RS05245	COG1757	Na H antiporter
EHC66_RS05250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EHC66_RS05255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHC66_RS05260	COG2095	MarC family integral membrane protein
EHC66_RS05265	COG1454	alcohol dehydrogenase
EHC66_RS05265	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_RS05285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EHC66_RS05295	COG2056	Na+-H+ antiporter family
EHC66_RS05300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHC66_RS05315	COG2885	chlorophyll binding
EHC66_RS05325	COG0346	lactoylglutathione lyase activity
EHC66_RS05330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EHC66_RS05335	COG4660	Part of a membrane complex involved in electron transport
EHC66_RS05340	COG4659	FMN binding
EHC66_RS05345	COG4658	electron transport chain
EHC66_RS05350	COG4656	Part of a membrane complex involved in electron transport
EHC66_RS05355	COG2878	Part of a membrane complex involved in electron transport
EHC66_RS05360	COG4657	Part of a membrane complex involved in electron transport
EHC66_RS05375	COG0556	nucleotide-excision repair
EHC66_RS05380	COG2204	response regulator
EHC66_RS05385	COG2198	Histidine kinase
EHC66_RS05390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EHC66_RS05395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EHC66_RS05400	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHC66_RS05405	COG0315	cyclic pyranopterin monophosphate synthase activity
EHC66_RS05410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EHC66_RS05415	COG0314	molybdopterin synthase activity
EHC66_RS05425	COG0601	transmembrane transport
EHC66_RS05430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHC66_RS05435	COG0444	Belongs to the ABC transporter superfamily
EHC66_RS05445	COG0435	Glutathione S-transferase
EHC66_RS05455	COG3174	membrane
EHC66_RS05460	COG0280	phosphate acetyltransferase
EHC66_RS05460	COG0857	belongs to the CobB CobQ family
EHC66_RS05465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHC66_RS05470	COG3092	negative regulation of chromosome organization
EHC66_RS05480	COG4120	Belongs to the binding-protein-dependent transport system permease family
EHC66_RS05485	COG1122	ATPase activity
EHC66_RS05490	COG0366	Alpha amylase catalytic
EHC66_RS05495	COG0745	RESPONSE REGULATOR receiver
EHC66_RS05495	COG3706	GGDEF domain
EHC66_RS05500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHC66_RS05505	COG0653	protein targeting
EHC66_RS05510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EHC66_RS05515	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHC66_RS05520	COG2186	Transcriptional regulator
EHC66_RS05530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHC66_RS05530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHC66_RS05535	COG0489	protein tyrosine kinase activity
EHC66_RS05540	COG0572	uridine kinase
EHC66_RS05550	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EHC66_RS05555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHC66_RS05560	COG0659	secondary active sulfate transmembrane transporter activity
EHC66_RS05565	COG1530	ribonuclease E activity
EHC66_RS05570	COG0564	pseudouridine synthase activity
EHC66_RS05575	COG0424	maF-like protein
EHC66_RS05580	COG1399	metal-binding, possibly nucleic acid-binding protein
EHC66_RS05590	COG0416	fatty acid biosynthetic process
EHC66_RS05595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHC66_RS05625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EHC66_RS05630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EHC66_RS05640	COG0084	hydrolase, TatD family'
EHC66_RS05645	COG1263	PTS System
EHC66_RS05645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_RS05665	COG0733	neurotransmitter:sodium symporter activity
EHC66_RS05680	COG4667	esterase of the alpha-beta hydrolase superfamily
EHC66_RS05685	COG0469	pyruvate kinase activity
EHC66_RS05690	COG1940	carbohydrate kinase activity
EHC66_RS05695	COG0784	Response regulator, receiver
EHC66_RS05695	COG0835	chemotaxis
EHC66_RS05700	COG0587	DNA-directed DNA polymerase activity
EHC66_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS05720	COG0616	signal peptide processing
EHC66_RS05725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EHC66_RS05730	COG0539	negative regulation of cytoplasmic translation
EHC66_RS05740	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EHC66_RS05745	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EHC66_RS05750	COG0284	orotidine-5'-phosphate decarboxylase activity
EHC66_RS05755	COG4166	transmembrane transport
EHC66_RS05780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EHC66_RS05790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHC66_RS05790	COG3008	intermembrane lipid transfer
EHC66_RS05795	COG2995	paraquat-inducible protein a
EHC66_RS05800	COG3258	Cytochrome c
EHC66_RS05805	COG2863	cytochrome
EHC66_RS05845	COG4232	protein-disulfide reductase activity
EHC66_RS05850	COG3118	belongs to the thioredoxin family
EHC66_RS05880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_RS05890	COG1136	(ABC) transporter
EHC66_RS05890	COG0577	efflux transmembrane transporter activity
EHC66_RS05895	COG1136	(ABC) transporter
EHC66_RS05895	COG0577	efflux transmembrane transporter activity
EHC66_RS05900	COG1136	(ABC) transporter
EHC66_RS05900	COG0577	efflux transmembrane transporter activity
EHC66_RS05905	COG1335	isochorismatase
EHC66_RS05920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHC66_RS05950	COG3850	Histidine kinase
EHC66_RS05950	COG5002	protein histidine kinase activity
EHC66_RS05955	COG0745	RESPONSE REGULATOR receiver
EHC66_RS06010	COG0840	transmembrane signaling receptor activity
EHC66_RS06015	COG1032	radical SAM domain protein
EHC66_RS06020	COG3706	GGDEF domain
EHC66_RS06020	COG2203	Gaf domain
EHC66_RS06020	COG4251	negative regulation of phosphorylation
EHC66_RS06020	COG5001	Diguanylate cyclase
EHC66_RS06035	COG0583	DNA-binding transcription factor activity
EHC66_RS06045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHC66_RS06055	COG2350	Protein conserved in bacteria
EHC66_RS06060	COG1607	acyl-coa hydrolase
EHC66_RS06065	COG2917	probably involved in intracellular septation
EHC66_RS06085	COG1301	dicarboxylic acid transport
EHC66_RS06095	COG0318	PFAM AMP-dependent synthetase and ligase
EHC66_RS06100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHC66_RS06110	COG0159	tryptophan synthase activity
EHC66_RS06115	COG0133	tryptophan synthase activity
EHC66_RS06120	COG0134	indole-3-glycerol-phosphate synthase activity
EHC66_RS06120	COG0135	phosphoribosylanthranilate isomerase activity
EHC66_RS06125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHC66_RS06130	COG0512	Glutamine amidotransferase of anthranilate synthase
EHC66_RS06135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EHC66_RS06145	COG0613	PHP domain protein
EHC66_RS06150	COG0009	L-threonylcarbamoyladenylate synthase
EHC66_RS06160	COG1187	pseudouridine synthase activity
EHC66_RS06170	COG3099	Belongs to the UPF0263 family
EHC66_RS06175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHC66_RS06185	COG0417	DNA replication proofreading
EHC66_RS06190	COG2197	response regulator
EHC66_RS06195	COG0322	excinuclease ABC activity
EHC66_RS06235	COG0019	diaminopimelate decarboxylase activity
EHC66_RS06260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHC66_RS06265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHC66_RS06270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHC66_RS06290	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EHC66_RS06305	COG0437	4 iron, 4 sulfur cluster binding
EHC66_RS06310	COG3301	Polysulphide reductase, NrfD
EHC66_RS06315	COG1138	Cytochrome C-type biogenesis protein
EHC66_RS06325	COG3088	subunit of a heme lyase
EHC66_RS06325	COG4235	cytochrome complex assembly
EHC66_RS06335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHC66_RS06360	COG2989	Protein conserved in bacteria
EHC66_RS06365	COG3108	Peptidase M15
EHC66_RS06370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHC66_RS06385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EHC66_RS06410	COG1846	Transcriptional regulator
EHC66_RS06415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHC66_RS06420	COG0840	transmembrane signaling receptor activity
EHC66_RS06440	COG1448	Aminotransferase
EHC66_RS06465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_RS06475	COG0017	Asparaginyl-tRNA synthetase
EHC66_RS06480	COG0840	transmembrane signaling receptor activity
EHC66_RS06485	COG0720	synthase
EHC66_RS06495	COG2200	EAL domain
EHC66_RS06500	COG1760	l-serine dehydratase
EHC66_RS06505	COG0814	amino acid
EHC66_RS06510	COG0494	nUDIX hydrolase
EHC66_RS06520	COG2205	protein histidine kinase activity
EHC66_RS06520	COG0784	Response regulator, receiver
EHC66_RS06525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EHC66_RS06545	COG3106	COG3106 Predicted ATPase
EHC66_RS06550	COG3768	UPF0283 membrane protein
EHC66_RS06560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHC66_RS06680	COG0454	-acetyltransferase
EHC66_RS06945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHC66_RS07055	COG0625	glutathione transferase activity
EHC66_RS07135	COG2314	TM2 domain
EHC66_RS07225	COG0494	nUDIX hydrolase
EHC66_RS07295	COG1757	Na H antiporter
EHC66_RS07300	COG0174	glutamine synthetase
EHC66_RS07310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EHC66_RS07315	COG1396	sequence-specific DNA binding
EHC66_RS07315	COG1917	Cupin 2, conserved barrel domain protein
EHC66_RS07320	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_RS07325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHC66_RS07335	COG2957	Belongs to the agmatine deiminase family
EHC66_RS07340	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_RS07345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHC66_RS07350	COG1227	inorganic diphosphatase activity
EHC66_RS07360	COG2771	luxR family
EHC66_RS07360	COG2200	EAL domain
EHC66_RS07370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHC66_RS07385	COG1846	Transcriptional regulator
EHC66_RS07390	COG2315	Protein conserved in bacteria
EHC66_RS07410	COG0110	maltose O-acetyltransferase activity
EHC66_RS07440	COG3063	Type IV pilus biogenesis stability protein PilW
EHC66_RS07445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EHC66_RS07460	COG0531	amino acid
EHC66_RS07470	COG1560	Kdo2-lipid A biosynthetic process
EHC66_RS07475	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EHC66_RS07480	COG1280	lysine exporter protein (LysE YggA)
EHC66_RS07490	COG1115	amino acid carrier protein
EHC66_RS07515	COG1368	sulfuric ester hydrolase activity
EHC66_RS07520	COG0642	Histidine kinase
EHC66_RS07525	COG0745	RESPONSE REGULATOR receiver
EHC66_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS07555	COG2113	Glycine betaine
EHC66_RS07560	COG4176	ABC-type proline glycine betaine transport system permease component
EHC66_RS07580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHC66_RS07585	COG0456	acetyltransferase
EHC66_RS07590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHC66_RS07595	COG0662	Cupin 2, conserved barrel domain protein
EHC66_RS07600	COG0527	aspartate kinase activity
EHC66_RS07605	COG1858	cytochrome C peroxidase
EHC66_RS07620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_RS07635	COG3290	protein histidine kinase activity
EHC66_RS07640	COG4565	transcriptional regulatory protein
EHC66_RS07645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EHC66_RS07650	COG0363	glucosamine-6-phosphate deaminase activity
EHC66_RS07655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EHC66_RS07675	COG3284	Transcriptional regulator
EHC66_RS07680	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_RS07750	COG4669	(LipO)protein
EHC66_RS07770	COG3177	Filamentation induced by cAMP protein fic
EHC66_RS07810	COG1073	alpha beta
EHC66_RS07815	COG1073	alpha beta
EHC66_RS07825	COG4792	protein secretion
EHC66_RS07830	COG4791	protein targeting
EHC66_RS07835	COG4794	Type iii secretion
EHC66_RS07840	COG4790	Type iii secretion
EHC66_RS07845	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHC66_RS07910	COG0457	Tetratricopeptide repeat
EHC66_RS07930	COG0730	response to heat
EHC66_RS07960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EHC66_RS07965	COG0372	Belongs to the citrate synthase family
EHC66_RS07975	COG2828	Protein conserved in bacteria
EHC66_RS08000	COG0561	phosphatase activity
EHC66_RS08005	COG0602	queuosine metabolic process
EHC66_RS08010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EHC66_RS08015	COG3706	GGDEF domain
EHC66_RS08055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHC66_RS08060	COG0840	transmembrane signaling receptor activity
EHC66_RS08065	COG1254	Belongs to the acylphosphatase family
EHC66_RS08070	COG2920	part of a sulfur-relay system
EHC66_RS08080	COG0670	Belongs to the BI1 family
EHC66_RS08085	COG1126	abc transporter atp-binding protein
EHC66_RS08090	COG0765	amino acid transport
EHC66_RS08095	COG4597	amino acid ABC transporter
EHC66_RS08100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_RS08115	COG1666	GTP binding
EHC66_RS08120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHC66_RS08140	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EHC66_RS08140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHC66_RS08145	COG3008	intermembrane lipid transfer
EHC66_RS08150	COG2995	paraquat-inducible protein a
EHC66_RS08155	COG1132	(ABC) transporter
EHC66_RS08160	COG1956	GAF domain-containing protein
EHC66_RS08165	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EHC66_RS08180	COG0308	aminopeptidase N
EHC66_RS08190	COG2902	Dehydrogenase
EHC66_RS08195	COG0167	dihydroorotate dehydrogenase activity
EHC66_RS08210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHC66_RS08210	COG0116	Belongs to the methyltransferase superfamily
EHC66_RS08235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHC66_RS08240	COG1067	ATP-dependent peptidase activity
EHC66_RS08245	COG3120	sequence-specific DNA binding
EHC66_RS08295	COG4128	Pfam Zonular occludens toxin
EHC66_RS08360	COG3278	Belongs to the heme-copper respiratory oxidase family
EHC66_RS08375	COG2010	Cytochrome c
EHC66_RS08385	COG2217	Heavy metal translocating P-type atpase
EHC66_RS08400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHC66_RS08405	COG0589	response to stress
EHC66_RS08415	COG0037	tRNA processing
EHC66_RS08435	COG3842	ATPase activity
EHC66_RS08440	COG1176	ABC-type spermidine putrescine transport system, permease component I
EHC66_RS08445	COG1177	transmembrane transport
EHC66_RS08450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EHC66_RS08455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EHC66_RS08460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EHC66_RS08470	COG0004	ammonium transporteR
EHC66_RS08495	COG0437	4 iron, 4 sulfur cluster binding
EHC66_RS08500	COG3383	formate dehydrogenase (NAD+) activity
EHC66_RS08500	COG0243	molybdopterin cofactor binding
EHC66_RS08510	COG3381	protein complex oligomerization
EHC66_RS08535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EHC66_RS08540	COG0488	(ABC) transporter
EHC66_RS08550	COG4191	Histidine kinase
EHC66_RS08555	COG2204	response regulator
EHC66_RS08575	COG3842	ATPase activity
EHC66_RS08580	COG0746	molybdenum cofactor guanylyltransferase activity
EHC66_RS08585	COG0303	'Molybdopterin
EHC66_RS08595	COG1940	carbohydrate kinase activity
EHC66_RS08635	COG0840	transmembrane signaling receptor activity
EHC66_RS08640	COG0791	NLP P60 protein
EHC66_RS08650	COG3706	GGDEF domain
EHC66_RS08655	COG2201	protein-glutamate methylesterase activity
EHC66_RS08670	COG0307	riboflavin synthase, alpha
EHC66_RS08675	COG0534	Mate efflux family protein
EHC66_RS08685	COG1793	dna ligase
EHC66_RS08720	COG2204	response regulator
EHC66_RS08765	COG0438	transferase activity, transferring glycosyl groups
EHC66_RS08770	COG1215	transferase activity, transferring glycosyl groups
EHC66_RS08775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EHC66_RS08785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHC66_RS08800	COG1643	Atp-dependent helicase
EHC66_RS08805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EHC66_RS08820	COG3302	dmso reductase anchor subunit
EHC66_RS08825	COG0437	4 iron, 4 sulfur cluster binding
EHC66_RS08830	COG0243	molybdopterin cofactor binding
EHC66_RS08870	COG0443	Heat shock 70 kDa protein
EHC66_RS08875	COG0443	Heat shock 70 kDa protein
EHC66_RS08905	COG1132	(ABC) transporter
EHC66_RS08910	COG1132	(ABC) transporter
EHC66_RS08935	COG0814	amino acid
EHC66_RS08950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EHC66_RS09040	COG1522	sequence-specific DNA binding
EHC66_RS09075	COG0515	serine threonine protein kinase
EHC66_RS09100	COG3501	Rhs element vgr protein
EHC66_RS09115	COG2204	response regulator
EHC66_RS09140	COG0739	heme binding
EHC66_RS09150	COG0861	Integral membrane protein TerC family
EHC66_RS09160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EHC66_RS09165	COG1328	CTP reductase activity
EHC66_RS09170	COG1280	lysine exporter protein (LysE YggA)
EHC66_RS09180	COG5001	Diguanylate cyclase
EHC66_RS09180	COG3300	MHYT domain
EHC66_RS09190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_RS09190	COG4191	Histidine kinase
EHC66_RS09195	COG0471	metal ion transport
EHC66_RS09230	COG0583	DNA-binding transcription factor activity
EHC66_RS09235	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EHC66_RS09295	COG0625	glutathione transferase activity
EHC66_RS09305	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EHC66_RS09315	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHC66_RS09325	COG0601	transmembrane transport
EHC66_RS09330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHC66_RS09335	COG0444	Belongs to the ABC transporter superfamily
EHC66_RS09355	COG3291	Pkd domain containing protein
EHC66_RS09365	COG1177	transmembrane transport
EHC66_RS09370	COG1176	ABC-type spermidine putrescine transport system, permease component I
EHC66_RS09375	COG3842	ATPase activity
EHC66_RS09380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHC66_RS09385	COG2423	ornithine cyclodeaminase activity
EHC66_RS09405	COG3938	Belongs to the proline racemase family
EHC66_RS09435	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EHC66_RS09440	COG1451	nucleotide metabolic process
EHC66_RS09445	COG3475	LICD family
EHC66_RS09450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHC66_RS09455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHC66_RS09475	COG0583	DNA-binding transcription factor activity
EHC66_RS09495	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EHC66_RS09500	COG4139	cobalamin transport
EHC66_RS09505	COG2988	succinylglutamate desuccinylase activity
EHC66_RS09530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EHC66_RS09535	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EHC66_RS09540	COG0702	epimerase
EHC66_RS09550	COG2925	Exonuclease
EHC66_RS09555	COG1380	Effector of murein hydrolase LrgA
EHC66_RS09560	COG1346	cytolysis
EHC66_RS09565	COG0295	cytidine deaminase activity
EHC66_RS09570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EHC66_RS09575	COG0500	methyltransferase
EHC66_RS09585	COG0776	regulation of translation
EHC66_RS09600	COG0072	phenylalanine-tRNA ligase activity
EHC66_RS09600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHC66_RS09605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EHC66_RS09610	COG3706	GGDEF domain
EHC66_RS09640	COG0393	Putative heavy-metal-binding
EHC66_RS09650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EHC66_RS09660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EHC66_RS09675	COG2188	Transcriptional regulator
EHC66_RS09680	COG1228	amidohydrolase
EHC66_RS09685	COG0010	Belongs to the arginase family
EHC66_RS09690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EHC66_RS09695	COG2986	histidine ammonia-lyase
EHC66_RS09710	COG0247	lactate metabolic process
EHC66_RS09710	COG0277	FAD linked oxidase domain protein
EHC66_RS09745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EHC66_RS09760	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
EHC66_RS09765	COG1643	Atp-dependent helicase
EHC66_RS09770	COG0281	malic enzyme
EHC66_RS09775	COG2949	membrane
EHC66_RS09780	COG0471	metal ion transport
EHC66_RS09785	COG3706	GGDEF domain
EHC66_RS09785	COG0745	RESPONSE REGULATOR receiver
EHC66_RS09805	COG0492	ferredoxin-NADP+ reductase activity
EHC66_RS09810	COG4988	ABC transporter
EHC66_RS09815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EHC66_RS09820	COG3048	D-serine ammonia-lyase activity
EHC66_RS09825	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EHC66_RS09835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_RS09835	COG4191	Histidine kinase
EHC66_RS09850	COG3070	regulator of competence-specific genes
EHC66_RS09865	COG2431	L-lysine efflux transmembrane transporter activity
EHC66_RS09875	COG0076	glutamate decarboxylase activity
EHC66_RS09880	COG1737	Transcriptional regulator
EHC66_RS09895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHC66_RS09900	COG3273	potassium ion transport
EHC66_RS09900	COG2985	domain, Protein
EHC66_RS09905	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EHC66_RS09920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHC66_RS09935	COG4181	ATPase activity
EHC66_RS09940	COG0534	Mate efflux family protein
EHC66_RS09945	COG0702	epimerase
EHC66_RS09950	COG3005	denitrification pathway
EHC66_RS09980	COG2814	Major facilitator Superfamily
EHC66_RS09985	COG1187	pseudouridine synthase activity
EHC66_RS09990	COG1061	Type III restriction enzyme res subunit
EHC66_RS10000	COG0745	RESPONSE REGULATOR receiver
EHC66_RS10005	COG2205	protein histidine kinase activity
EHC66_RS10010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EHC66_RS10040	COG3313	Fe-S protein
EHC66_RS10065	COG0493	'glutamate synthase
EHC66_RS10075	COG0398	Pfam SNARE associated Golgi protein
EHC66_RS10080	COG4134	Bacterial extracellular solute-binding protein
EHC66_RS10085	COG4135	transport system, permease component
EHC66_RS10090	COG4136	ATPase activity
EHC66_RS10095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EHC66_RS10110	COG3604	Transcriptional regulator
EHC66_RS10115	COG1151	hydroxylamine reductase activity
EHC66_RS10120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHC66_RS10130	COG0564	pseudouridine synthase activity
EHC66_RS10140	COG0733	neurotransmitter:sodium symporter activity
EHC66_RS10150	COG0626	cystathionine gamma-synthase activity
EHC66_RS10155	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EHC66_RS10160	COG5380	lipid catabolic process
EHC66_RS10165	COG2818	Glycosylase
EHC66_RS10180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_RS10185	COG1983	PspC domain protein
EHC66_RS10195	COG1842	Phage shock protein A
EHC66_RS10200	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EHC66_RS10210	COG4168	peptide transport system, permease
EHC66_RS10215	COG4171	peptide transport system, permease
EHC66_RS10225	COG4172	Belongs to the ABC transporter superfamily
EHC66_RS10235	COG1227	inorganic diphosphatase activity
EHC66_RS10250	COG0243	molybdopterin cofactor binding
EHC66_RS10255	COG3005	denitrification pathway
EHC66_RS10260	COG4459	periplasmic nitrate reductase
EHC66_RS10265	COG0390	transport system, permease component
EHC66_RS10275	COG2116	formate transmembrane transporter activity
EHC66_RS10300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EHC66_RS10305	COG1435	thymidine kinase activity
EHC66_RS10310	COG0215	cysteine-tRNA ligase activity
EHC66_RS10315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHC66_RS10320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_RS10325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EHC66_RS10335	COG3012	SEC-C Motif Domain Protein
EHC66_RS10340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EHC66_RS10340	COG0140	phosphoribosyl-ATP diphosphatase activity
EHC66_RS10345	COG0107	imidazoleglycerol-phosphate synthase activity
EHC66_RS10350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EHC66_RS10355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EHC66_RS10360	COG0131	Imidazoleglycerol-phosphate dehydratase
EHC66_RS10360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHC66_RS10365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHC66_RS10370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EHC66_RS10375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EHC66_RS10390	COG1757	Na H antiporter
EHC66_RS10400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_RS10410	COG0482	sulfurtransferase activity
EHC66_RS10415	COG2915	High frequency lysogenization protein hflD homolog
EHC66_RS10420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EHC66_RS10445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHC66_RS10460	COG0300	oxidoreductase activity
EHC66_RS10470	COG0501	Belongs to the peptidase M48B family
EHC66_RS10480	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EHC66_RS10490	COG0156	8-amino-7-oxononanoate synthase activity
EHC66_RS10495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EHC66_RS10500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EHC66_RS10505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EHC66_RS10520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EHC66_RS10525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EHC66_RS10530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EHC66_RS10535	COG1674	ftsk spoiiie
EHC66_RS10545	COG0686	Belongs to the AlaDH PNT family
EHC66_RS10555	COG0583	DNA-binding transcription factor activity
EHC66_RS10570	COG3568	Endonuclease Exonuclease Phosphatase
EHC66_RS10600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_RS10605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_RS10620	COG0840	transmembrane signaling receptor activity
EHC66_RS10785	COG2885	chlorophyll binding
EHC66_RS10790	COG0823	Involved in the tonB-independent uptake of proteins
EHC66_RS10805	COG0811	peptide transport
EHC66_RS10810	COG0824	Thioesterase
EHC66_RS10820	COG4890	Cyd operon protein YbgT
EHC66_RS10825	COG1294	oxidase, subunit
EHC66_RS10830	COG1271	oxidase subunit
EHC66_RS10835	COG2255	four-way junction helicase activity
EHC66_RS10840	COG0632	four-way junction helicase activity
EHC66_RS10845	COG0840	transmembrane signaling receptor activity
EHC66_RS10850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EHC66_RS10855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EHC66_RS10860	COG1801	Protein of unknown function DUF72
EHC66_RS10865	COG4106	trans-aconitate 2-methyltransferase activity
EHC66_RS10870	COG0500	methyltransferase
EHC66_RS10880	COG4067	protein conserved in archaea
EHC66_RS10880	COG0189	ligase activity
EHC66_RS10900	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EHC66_RS10905	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EHC66_RS10910	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EHC66_RS10915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHC66_RS10920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EHC66_RS10925	COG0745	RESPONSE REGULATOR receiver
EHC66_RS10930	COG3381	protein complex oligomerization
EHC66_RS10935	COG1609	Transcriptional regulator
EHC66_RS10940	COG3070	regulator of competence-specific genes
EHC66_RS10960	COG0297	glycogen (starch) synthase activity
EHC66_RS10965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EHC66_RS10970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHC66_RS10980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EHC66_RS10990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EHC66_RS10995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EHC66_RS11000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EHC66_RS11010	COG0542	response to heat
EHC66_RS11015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EHC66_RS11020	COG1278	Cold shock
EHC66_RS11030	COG1187	pseudouridine synthase activity
EHC66_RS11035	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EHC66_RS11045	COG1199	ATP-dependent helicase activity
EHC66_RS11050	COG0730	response to heat
EHC66_RS11055	COG3923	Primosomal replication protein n
EHC66_RS11065	COG0708	Exodeoxyribonuclease III
EHC66_RS11080	COG4215	(ABC) transporter
EHC66_RS11110	COG1882	Formate acetyltransferase
EHC66_RS11120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EHC66_RS11130	COG3013	Belongs to the UPF0304 family
EHC66_RS11140	COG2766	serine protein kinase
EHC66_RS11145	COG2718	Belongs to the UPF0229 family
EHC66_RS11150	COG2719	SpoVR family
EHC66_RS11155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EHC66_RS11165	COG1663	tetraacyldisaccharide 4'-kinase activity
EHC66_RS11170	COG1132	(ABC) transporter
EHC66_RS11175	COG0658	competence protein
EHC66_RS11175	COG2333	competence protein COMEC
EHC66_RS11185	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHC66_RS11190	COG1136	(ABC) transporter
EHC66_RS11195	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHC66_RS11205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EHC66_RS11220	COG1252	NADH dehydrogenase
EHC66_RS11230	COG3150	esterase
EHC66_RS11255	COG0537	adenosine 5'-monophosphoramidase activity
EHC66_RS11285	COG0516	GMP reductase activity
EHC66_RS11285	COG0517	IMP dehydrogenase activity
EHC66_RS11295	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EHC66_RS11300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EHC66_RS11305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHC66_RS11315	COG2199	diguanylate cyclase activity
EHC66_RS11330	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EHC66_RS11335	COG1946	Acyl-CoA thioesterase
EHC66_RS11345	COG1522	sequence-specific DNA binding
EHC66_RS11375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_RS11425	COG0477	Major facilitator Superfamily
EHC66_RS11430	COG2855	membrane
EHC66_RS11445	COG1441	menaquinone biosynthetic process
EHC66_RS11450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EHC66_RS11455	COG0596	Alpha beta hydrolase
EHC66_RS11460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EHC66_RS11465	COG1169	isochorismate synthase
EHC66_RS11470	COG0436	Aminotransferase
EHC66_RS11475	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EHC66_RS11480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EHC66_RS11495	COG1555	photosystem II stabilization
EHC66_RS11500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHC66_RS11505	COG0776	regulation of translation
EHC66_RS11510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EHC66_RS11515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EHC66_RS11525	COG0544	peptidyl-prolyl cis-trans isomerase activity
EHC66_RS11535	COG2204	response regulator
EHC66_RS11545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EHC66_RS11550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EHC66_RS11555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EHC66_RS11560	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EHC66_RS11580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHC66_RS11585	COG0569	domain protein
EHC66_RS11590	COG0513	Belongs to the DEAD box helicase family
EHC66_RS11595	COG1253	flavin adenine dinucleotide binding
EHC66_RS11630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHC66_RS11635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHC66_RS11650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHC66_RS11655	COG1216	Glycosyl transferase, family 2
EHC66_RS11660	COG2986	histidine ammonia-lyase
EHC66_RS11685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHC66_RS11690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHC66_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS11715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHC66_RS11720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHC66_RS11725	COG0583	DNA-binding transcription factor activity
EHC66_RS11730	COG2951	lytic endotransglycosylase activity
EHC66_RS11735	COG3100	YcgL domain-containing protein
EHC66_RS11740	COG0850	regulation of cytokinetic process
EHC66_RS11745	COG2894	cell division
EHC66_RS11750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EHC66_RS11755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EHC66_RS11760	COG0318	PFAM AMP-dependent synthetase and ligase
EHC66_RS11765	COG2267	carboxylic ester hydrolase activity
EHC66_RS11780	COG1214	PFAM Peptidase M22, glycoprotease
EHC66_RS11785	COG1199	ATP-dependent helicase activity
EHC66_RS11790	COG0788	formyltetrahydrofolate deformylase activity
EHC66_RS11795	COG3102	Protein conserved in bacteria
EHC66_RS11805	COG0018	arginyl-trna synthetase
EHC66_RS11825	COG1918	ferrous iron import across plasma membrane
EHC66_RS11840	COG4977	sequence-specific DNA binding
EHC66_RS11845	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EHC66_RS11850	COG1121	(ABC) transporter
EHC66_RS11855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHC66_RS11865	COG0045	succinate-CoA ligase (ADP-forming) activity
EHC66_RS11870	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHC66_RS11875	COG0567	Dehydrogenase, E1 component
EHC66_RS11880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHC66_RS11885	COG1053	succinate dehydrogenase
EHC66_RS11890	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EHC66_RS11895	COG2009	succinate dehydrogenase
EHC66_RS11905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EHC66_RS11915	COG0033	Phosphoglucomutase
EHC66_RS11920	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EHC66_RS11925	COG0596	Alpha beta hydrolase
EHC66_RS11935	COG0716	FMN binding
EHC66_RS11945	COG0735	belongs to the Fur family
EHC66_RS11950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHC66_RS11955	COG1263	PTS System
EHC66_RS11955	COG2190	(PTS) system
EHC66_RS11955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_RS11965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EHC66_RS11970	COG1940	carbohydrate kinase activity
EHC66_RS11970	COG1846	Transcriptional regulator
EHC66_RS11975	COG4651	solute:proton antiporter activity
EHC66_RS11975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHC66_RS11980	COG0367	asparagine synthase
EHC66_RS11985	COG0250	Participates in transcription elongation, termination and antitermination
EHC66_RS11990	COG3104	oligopeptide transport
EHC66_RS11995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EHC66_RS12000	COG0563	adenylate kinase activity
EHC66_RS12005	COG0326	Molecular chaperone. Has ATPase activity
EHC66_RS12010	COG3710	Transcriptional regulator
EHC66_RS12030	COG0622	Phosphoesterase
EHC66_RS12060	COG1090	epimerase
EHC66_RS12065	COG0300	oxidoreductase activity
EHC66_RS12075	COG3118	belongs to the thioredoxin family
EHC66_RS12080	COG0330	HflC and HflK could
EHC66_RS12105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHC66_RS12110	COG3115	cell septum assembly
EHC66_RS12115	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EHC66_RS12120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EHC66_RS12130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS12135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHC66_RS12140	COG2190	(PTS) system
EHC66_RS12150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS12155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS12165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS12175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS12185	COG3951	Flagellar rod assembly protein muramidase FlgJ
EHC66_RS12185	COG1705	Flagellar rod assembly protein muramidase FlgJ
EHC66_RS12190	COG1706	bacterial-type flagellum-dependent cell motility
EHC66_RS12195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EHC66_RS12200	COG4786	Flagellar basal body rod
EHC66_RS12205	COG4787	bacterial-type flagellum-dependent cell motility
EHC66_RS12215	COG1749	Flagellar hook protein flgE
EHC66_RS12220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EHC66_RS12225	COG1558	bacterial-type flagellum-dependent cell motility
EHC66_RS12230	COG1815	bacterial-type flagellum-dependent cell motility
EHC66_RS12235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EHC66_RS12240	COG0835	chemotaxis
EHC66_RS12240	COG0784	Response regulator, receiver
EHC66_RS12300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHC66_RS12305	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EHC66_RS12320	COG2608	mercury ion transmembrane transporter activity
EHC66_RS12320	COG2217	Heavy metal translocating P-type atpase
EHC66_RS12360	COG2840	Smr protein MutS2
EHC66_RS12365	COG1187	pseudouridine synthase activity
EHC66_RS12375	COG0737	Belongs to the 5'-nucleotidase family
EHC66_RS12380	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EHC66_RS12385	COG2912	Transglutaminase-like superfamily
EHC66_RS12390	COG3094	Invasion gene expression up-regulator, SirB
EHC66_RS12395	COG2890	protein-(glutamine-N5) methyltransferase activity
EHC66_RS12400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EHC66_RS12405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EHC66_RS12410	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EHC66_RS12415	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EHC66_RS12420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EHC66_RS12425	COG0193	aminoacyl-tRNA hydrolase activity
EHC66_RS12430	COG0012	GTP binding
EHC66_RS12525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHC66_RS12535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHC66_RS12540	COG1702	phosphate starvation-inducible protein PhoH
EHC66_RS12545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EHC66_RS12550	COG4535	Mg2 and Co2 transporter CorC
EHC66_RS12555	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EHC66_RS12560	COG2888	peptidyl-tyrosine sulfation
EHC66_RS12565	COG0495	leucyl-tRNA aminoacylation
EHC66_RS12570	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EHC66_RS12575	COG1466	dna polymerase III delta subunit
EHC66_RS12580	COG0799	negative regulation of ribosome biogenesis
EHC66_RS12585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EHC66_RS12590	COG0768	penicillin binding
EHC66_RS12595	COG0772	Belongs to the SEDS family
EHC66_RS12600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EHC66_RS12605	COG1686	Belongs to the peptidase S11 family
EHC66_RS12610	COG2921	Belongs to the UPF0250 family
EHC66_RS12615	COG0321	lipoyl(octanoyl) transferase activity
EHC66_RS12620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EHC66_RS12625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHC66_RS12630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EHC66_RS12645	COG0366	Alpha amylase catalytic
EHC66_RS12650	COG1263	PTS System
EHC66_RS12650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_RS12660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHC66_RS12670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EHC66_RS12675	COG2011	ABC-type metal ion transport system permease component
EHC66_RS12680	COG1464	Belongs to the NlpA lipoprotein family
EHC66_RS12685	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EHC66_RS12695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHC66_RS12695	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHC66_RS12705	COG3706	GGDEF domain
EHC66_RS12705	COG0745	RESPONSE REGULATOR receiver
EHC66_RS12710	COG1611	Belongs to the LOG family
EHC66_RS12715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHC66_RS12725	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EHC66_RS12730	COG2363	Small membrane protein
EHC66_RS12740	COG0583	DNA-binding transcription factor activity
EHC66_RS12745	COG0301	tRNA thio-modification
EHC66_RS12745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHC66_RS12750	COG2885	chlorophyll binding
EHC66_RS12755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EHC66_RS12760	COG1722	exodeoxyribonuclease VII activity
EHC66_RS12765	COG0142	geranyltranstransferase activity
EHC66_RS12770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EHC66_RS12775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EHC66_RS12780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EHC66_RS12785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHC66_RS12805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHC66_RS12805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHC66_RS12810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EHC66_RS12815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EHC66_RS12820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EHC66_RS12835	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EHC66_RS12840	COG2252	PERMEase
EHC66_RS12845	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHC66_RS12870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EHC66_RS12870	COG0047	phosphoribosylformylglycinamidine synthase activity
EHC66_RS12875	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EHC66_RS12885	COG0590	tRNA wobble adenosine to inosine editing
EHC66_RS12890	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EHC66_RS12930	COG0484	heat shock protein binding
EHC66_RS12935	COG0443	Heat shock 70 kDa protein
EHC66_RS12945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHC66_RS12950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EHC66_RS12960	COG0497	DNA recombination
EHC66_RS12965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHC66_RS12970	COG2914	Belongs to the UPF0125 (RnfH) family
EHC66_RS12975	COG2867	negative regulation of translational initiation
EHC66_RS12980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EHC66_RS13000	COG0583	DNA-binding transcription factor activity
EHC66_RS13005	COG3153	acetyltransferase
EHC66_RS13005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHC66_RS13025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EHC66_RS13030	COG2873	o-acetylhomoserine
EHC66_RS13065	COG1115	amino acid carrier protein
EHC66_RS13075	COG1584	GPR1 FUN34 yaaH family protein
EHC66_RS13085	COG1757	Na H antiporter
EHC66_RS13090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EHC66_RS13090	COG0519	Catalyzes the synthesis of GMP from XMP
EHC66_RS13095	COG0517	IMP dehydrogenase activity
EHC66_RS13095	COG0516	GMP reductase activity
EHC66_RS13100	COG1570	exodeoxyribonuclease VII activity
EHC66_RS13115	COG1160	GTP binding
EHC66_RS13120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHC66_RS13125	COG2976	Protein conserved in bacteria
EHC66_RS13130	COG0124	histidyl-tRNA synthetase
EHC66_RS13135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EHC66_RS13150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EHC66_RS13155	COG0105	UTP biosynthetic process
EHC66_RS13160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHC66_RS13165	COG2975	iron-sulfur cluster assembly
EHC66_RS13170	COG0633	Ferredoxin
EHC66_RS13175	COG0443	Heat shock 70 kDa protein
EHC66_RS13180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EHC66_RS13190	COG0822	iron-sulfur transferase activity
EHC66_RS13195	COG1104	cysteine desulfurase activity
EHC66_RS13210	COG0483	inositol monophosphate 1-phosphatase activity
EHC66_RS13220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHC66_RS13225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHC66_RS13230	COG1862	Preprotein translocase
EHC66_RS13235	COG0343	queuine tRNA-ribosyltransferase activity
EHC66_RS13240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EHC66_RS13250	COG0517	IMP dehydrogenase activity
EHC66_RS13260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EHC66_RS13270	COG0583	DNA-binding transcription factor activity
EHC66_RS13275	COG0450	alkyl hydroperoxide reductase
EHC66_RS13280	COG3142	Participates in the control of copper homeostasis
EHC66_RS13290	COG0704	Plays a role in the regulation of phosphate uptake
EHC66_RS13295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHC66_RS13300	COG0581	inorganic phosphate transmembrane transporter activity
EHC66_RS13310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EHC66_RS13315	COG0248	Ppx GppA phosphatase
EHC66_RS13325	COG5002	protein histidine kinase activity
EHC66_RS13330	COG0745	RESPONSE REGULATOR receiver
EHC66_RS13335	COG2974	May be involved in recombination
EHC66_RS13345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EHC66_RS13405	COG0542	response to heat
EHC66_RS13415	COG0564	pseudouridine synthase activity
EHC66_RS13420	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHC66_RS13425	COG0741	lytic transglycosylase activity
EHC66_RS13430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHC66_RS13435	COG0077	Prephenate dehydratase
EHC66_RS13435	COG1605	Chorismate mutase
EHC66_RS13440	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EHC66_RS13445	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EHC66_RS13455	COG0488	(ABC) transporter
EHC66_RS13470	COG0739	heme binding
EHC66_RS13475	COG1605	Chorismate mutase
EHC66_RS13475	COG0287	Prephenate dehydrogenase
EHC66_RS13480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHC66_RS13485	COG1472	Belongs to the glycosyl hydrolase 3 family
EHC66_RS13490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EHC66_RS13495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EHC66_RS13510	COG1966	Carbon starvation protein
EHC66_RS13515	COG3275	phosphorelay sensor kinase activity
EHC66_RS13520	COG3279	Response regulator of the LytR AlgR family
EHC66_RS13525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EHC66_RS13530	COG1047	Peptidyl-prolyl cis-trans
EHC66_RS13535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHC66_RS13540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHC66_RS13545	COG0196	riboflavin kinase activity
EHC66_RS13550	COG0728	peptidoglycan biosynthetic process
EHC66_RS13555	COG0268	Binds directly to 16S ribosomal RNA
EHC66_RS13565	COG0640	Transcriptional regulator
EHC66_RS13575	COG0583	DNA-binding transcription factor activity
EHC66_RS13580	COG1283	sodium-dependent phosphate transmembrane transporter activity
EHC66_RS13590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EHC66_RS13595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EHC66_RS13600	COG0730	response to heat
EHC66_RS13610	COG0494	nUDIX hydrolase
EHC66_RS13620	COG3066	DNA modification
EHC66_RS13630	COG0667	Aldo Keto reductase
EHC66_RS13645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EHC66_RS13655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EHC66_RS13660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHC66_RS13670	COG0716	FMN binding
EHC66_RS13680	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EHC66_RS13685	COG0513	Belongs to the DEAD box helicase family
EHC66_RS13690	COG3022	response to hydroperoxide
EHC66_RS13695	COG1115	amino acid carrier protein
EHC66_RS13710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHC66_RS13720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EHC66_RS13725	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EHC66_RS13730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EHC66_RS13735	COG0083	homoserine kinase activity
EHC66_RS13750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHC66_RS13765	COG0745	RESPONSE REGULATOR receiver
EHC66_RS13775	COG2198	Histidine kinase
EHC66_RS13775	COG0784	Response regulator, receiver
EHC66_RS13775	COG5002	protein histidine kinase activity
EHC66_RS13780	COG3706	GGDEF domain
EHC66_RS13780	COG2203	Gaf domain
EHC66_RS13780	COG4251	negative regulation of phosphorylation
EHC66_RS13780	COG5001	Diguanylate cyclase
EHC66_RS13785	COG1242	4 iron, 4 sulfur cluster binding
EHC66_RS13790	COG0070	glutamate synthase
EHC66_RS13790	COG0069	glutamate synthase activity
EHC66_RS13790	COG0067	glutamate synthase
EHC66_RS13800	COG0067	glutamate synthase
EHC66_RS13800	COG0070	glutamate synthase
EHC66_RS13800	COG0069	glutamate synthase activity
EHC66_RS13805	COG0493	'glutamate synthase
EHC66_RS13815	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHC66_RS13825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHC66_RS13830	COG2860	membrane
EHC66_RS13835	COG0583	DNA-binding transcription factor activity
EHC66_RS13840	COG0730	response to heat
EHC66_RS13855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EHC66_RS13860	COG0505	Belongs to the CarA family
EHC66_RS13865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EHC66_RS13870	COG0494	nUDIX hydrolase
EHC66_RS13875	COG0653	protein targeting
EHC66_RS13885	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EHC66_RS13890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EHC66_RS13895	COG0849	cell division
EHC66_RS13900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EHC66_RS13905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHC66_RS13910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EHC66_RS13915	COG0772	Belongs to the SEDS family
EHC66_RS13920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EHC66_RS13925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHC66_RS13930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EHC66_RS13935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EHC66_RS13940	COG0768	penicillin binding
EHC66_RS13945	COG3116	cell division
EHC66_RS13950	COG0275	rRNA processing
EHC66_RS13965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EHC66_RS13975	COG0792	nuclease activity
EHC66_RS13980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHC66_RS13985	COG2823	Periplasmic or secreted lipoprotein
EHC66_RS13990	COG2969	positive regulation of protein catabolic process
EHC66_RS13995	COG0625	glutathione transferase activity
EHC66_RS14000	COG2857	Cytochrome c1
EHC66_RS14005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EHC66_RS14010	COG0723	plastoquinol--plastocyanin reductase activity
EHC66_RS14015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EHC66_RS14020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EHC66_RS14030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EHC66_RS14040	COG3105	Protein conserved in bacteria
EHC66_RS14050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHC66_RS14055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EHC66_RS14060	COG0187	DNA topoisomerase II activity
EHC66_RS14065	COG3150	esterase
EHC66_RS14075	COG3151	Protein conserved in bacteria
EHC66_RS14080	COG0494	nUDIX hydrolase
EHC66_RS14085	COG1538	Outer membrane efflux protein
EHC66_RS14090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EHC66_RS14090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EHC66_RS14095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EHC66_RS14110	COG3025	triphosphatase activity
EHC66_RS14115	COG1392	Phosphate transport regulator
EHC66_RS14120	COG0306	phosphate transporter
EHC66_RS14125	COG4991	sh3 domain protein
EHC66_RS14135	COG3267	Type II secretory pathway component ExeA
EHC66_RS14135	COG3409	Peptidoglycan-binding domain 1 protein
EHC66_RS14140	COG0617	tRNA 3'-terminal CCA addition
EHC66_RS14145	COG1968	undecaprenyl-diphosphatase activity
EHC66_RS14150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EHC66_RS14155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EHC66_RS14160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EHC66_RS14165	COG0596	Alpha beta hydrolase
EHC66_RS14170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EHC66_RS14175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EHC66_RS14180	COG1610	YqeY-like protein
EHC66_RS14185	COG0358	DNA primase activity
EHC66_RS14190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EHC66_RS14235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS14280	COG1464	Belongs to the NlpA lipoprotein family
EHC66_RS14315	COG2213	PTS system mannitol-specific
EHC66_RS14315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS14320	COG0246	Mannitol dehydrogenase
EHC66_RS14325	COG3722	fumarate hydratase activity
EHC66_RS14330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHC66_RS14335	COG5002	protein histidine kinase activity
EHC66_RS14350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHC66_RS14355	COG1349	DNA-binding transcription factor activity
EHC66_RS14365	COG0469	pyruvate kinase activity
EHC66_RS14375	COG3706	GGDEF domain
EHC66_RS14380	COG0440	acetolactate synthase activity
EHC66_RS14385	COG0028	Belongs to the TPP enzyme family
EHC66_RS14390	COG1022	Amp-dependent synthetase and ligase
EHC66_RS14395	COG0583	DNA-binding transcription factor activity
EHC66_RS14415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHC66_RS14420	COG0473	3-isopropylmalate dehydrogenase activity
EHC66_RS14425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHC66_RS14430	COG0066	3-isopropylmalate dehydratase activity
EHC66_RS14440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EHC66_RS14445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EHC66_RS14450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHC66_RS14455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EHC66_RS14460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EHC66_RS14465	COG2967	ApaG domain
EHC66_RS14470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHC66_RS14485	COG2966	Psort location CytoplasmicMembrane, score
EHC66_RS14490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EHC66_RS14500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EHC66_RS14505	COG0142	geranyltranstransferase activity
EHC66_RS14515	COG0039	L-malate dehydrogenase activity
EHC66_RS14550	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EHC66_RS14555	COG1178	ABC-type Fe3 transport system permease component
EHC66_RS14560	COG4143	(ABC) transporter
EHC66_RS14565	COG0163	prenyltransferase activity
EHC66_RS14570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHC66_RS14580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EHC66_RS14585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EHC66_RS14595	COG2105	PFAM AIG2 family protein
EHC66_RS14600	COG2911	Protein conserved in bacteria
EHC66_RS14605	COG0729	surface antigen
EHC66_RS14610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHC66_RS14620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EHC66_RS14635	COG1136	(ABC) transporter
EHC66_RS14655	COG0529	Catalyzes the synthesis of activated sulfate
EHC66_RS14660	COG3273	potassium ion transport
EHC66_RS14660	COG0471	metal ion transport
EHC66_RS14670	COG2895	sulfate adenylyltransferase (ATP) activity
EHC66_RS14675	COG0175	sulfate reduction
EHC66_RS14680	COG1648	precorrin-2 dehydrogenase activity
EHC66_RS14680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHC66_RS14685	COG0737	Belongs to the 5'-nucleotidase family
EHC66_RS14695	COG0513	Belongs to the DEAD box helicase family
EHC66_RS14700	COG2153	protein acetylation
EHC66_RS14710	COG0545	Peptidyl-prolyl cis-trans isomerase
EHC66_RS14720	COG0203	ribosomal protein L17
EHC66_RS14725	COG0202	RNA polymerase activity
EHC66_RS14735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EHC66_RS14740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EHC66_RS14750	COG0201	protein transport
EHC66_RS14755	COG0200	Binds to the 23S rRNA
EHC66_RS14760	COG1841	ribosomal large subunit assembly
EHC66_RS14775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EHC66_RS14780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EHC66_RS14785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EHC66_RS14790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EHC66_RS14795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EHC66_RS14800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EHC66_RS14805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EHC66_RS14810	COG0255	Belongs to the universal ribosomal protein uL29 family
EHC66_RS14820	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EHC66_RS14825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EHC66_RS14830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EHC66_RS14835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EHC66_RS14845	COG0088	Forms part of the polypeptide exit tunnel
EHC66_RS14850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EHC66_RS14860	COG0254	rRNA binding
EHC66_RS14870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EHC66_RS14875	COG1609	Transcriptional regulator
EHC66_RS14885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EHC66_RS14890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EHC66_RS14905	COG2003	Belongs to the UPF0758 family
EHC66_RS14935	COG1575	Belongs to the MenA family. Type 1 subfamily
EHC66_RS14940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHC66_RS14945	COG3074	FtsZ-dependent cytokinesis
EHC66_RS14955	COG1494	fructose-1,6-bisphosphatase
EHC66_RS14980	COG0149	triose-phosphate isomerase activity
EHC66_RS14985	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EHC66_RS15005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EHC66_RS15025	COG0438	transferase activity, transferring glycosyl groups
EHC66_RS15045	COG1215	transferase activity, transferring glycosyl groups
EHC66_RS15050	COG0110	maltose O-acetyltransferase activity
EHC66_RS15060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHC66_RS15115	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHC66_RS15125	COG1560	Kdo2-lipid A biosynthetic process
EHC66_RS15130	COG0859	PFAM glycosyl transferase family 9
EHC66_RS15135	COG1519	Transferase
EHC66_RS15145	COG0438	transferase activity, transferring glycosyl groups
EHC66_RS15145	COG0297	glycogen (starch) synthase activity
EHC66_RS15165	COG2030	dehydratase
EHC66_RS15170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_RS15190	COG3642	lipopolysaccharide core region biosynthetic process
EHC66_RS15195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EHC66_RS15200	COG0859	PFAM glycosyl transferase family 9
EHC66_RS15205	COG0463	Glycosyl transferase, family 2
EHC66_RS15210	COG0438	transferase activity, transferring glycosyl groups
EHC66_RS15225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHC66_RS15240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EHC66_RS15245	COG2003	Belongs to the UPF0758 family
EHC66_RS15250	COG0840	transmembrane signaling receptor activity
EHC66_RS15260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EHC66_RS15265	COG1309	transcriptional regulator
EHC66_RS15270	COG1560	Kdo2-lipid A biosynthetic process
EHC66_RS15275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EHC66_RS15280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EHC66_RS15285	COG1561	YicC-like family, N-terminal region
EHC66_RS15295	COG4608	Belongs to the ABC transporter superfamily
EHC66_RS15300	COG0444	Belongs to the ABC transporter superfamily
EHC66_RS15305	COG0747	negative chemotaxis
EHC66_RS15310	COG4239	(ABC) transporter, permease
EHC66_RS15315	COG4174	ABC transporter (Permease)
EHC66_RS15340	COG0811	peptide transport
EHC66_RS15345	COG0848	biopolymer transport protein
EHC66_RS15360	COG0194	GDP metabolic process
EHC66_RS15365	COG1758	RNA polymerase activity
EHC66_RS15370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHC66_RS15375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHC66_RS15380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHC66_RS15385	COG2233	PERMEase
EHC66_RS15390	COG2205	protein histidine kinase activity
EHC66_RS15395	COG0745	RESPONSE REGULATOR receiver
EHC66_RS15405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHC66_RS15415	COG2183	response to ionizing radiation
EHC66_RS15425	COG0596	Alpha beta hydrolase
EHC66_RS15430	COG1040	competence protein
EHC66_RS15435	COG0316	Belongs to the HesB IscA family
EHC66_RS15435	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EHC66_RS15440	COG0494	nUDIX hydrolase
EHC66_RS15445	COG1218	3'(2'),5'-bisphosphate nucleotidase
EHC66_RS15455	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EHC66_RS15460	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EHC66_RS15465	COG3156	type II secretion system protein K
EHC66_RS15470	COG4795	General secretion pathway protein
EHC66_RS15475	COG2165	general secretion pathway protein
EHC66_RS15480	COG2165	general secretion pathway protein
EHC66_RS15485	COG2165	general secretion pathway protein
EHC66_RS15490	COG1459	type II secretion system
EHC66_RS15495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHC66_RS15505	COG3031	protein transport across the cell outer membrane
EHC66_RS15510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EHC66_RS15515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EHC66_RS15520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EHC66_RS15530	COG0456	acetyltransferase
EHC66_RS15535	COG1490	D-aminoacyl-tRNA deacylase activity
EHC66_RS15540	COG1295	ribonuclease BN
EHC66_RS15560	COG0174	glutamine synthetase
EHC66_RS15570	COG3852	Histidine kinase
EHC66_RS15575	COG2204	response regulator
EHC66_RS15585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EHC66_RS15590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHC66_RS15620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EHC66_RS15630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHC66_RS15630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHC66_RS15655	COG0084	hydrolase, TatD family'
EHC66_RS15665	COG0805	protein transport
EHC66_RS15675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHC66_RS15680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EHC66_RS15685	COG3165	ubiquinone biosynthetic process from chorismate
EHC66_RS15690	COG2226	methyltransferase
EHC66_RS15695	COG1322	Protein conserved in bacteria
EHC66_RS15710	COG0628	permease
EHC66_RS15760	COG2823	Periplasmic or secreted lipoprotein
EHC66_RS15770	COG2081	HI0933 family
EHC66_RS15780	COG1528	Iron-storage protein
EHC66_RS15785	COG0589	response to stress
EHC66_RS15790	COG0697	spore germination
EHC66_RS15800	COG0742	ribosomal rna small subunit methyltransferase
EHC66_RS15805	COG5002	protein histidine kinase activity
EHC66_RS15805	COG5001	Diguanylate cyclase
EHC66_RS15810	COG1522	sequence-specific DNA binding
EHC66_RS15815	COG0339	signal peptide processing
EHC66_RS15820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EHC66_RS15825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHC66_RS15830	COG0583	DNA-binding transcription factor activity
EHC66_RS15835	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EHC66_RS15840	COG0800	Aldolase
EHC66_RS15845	COG2610	gluconate transmembrane transporter activity
EHC66_RS15850	COG3265	gluconokinase activity
EHC66_RS15855	COG0129	dihydroxy-acid dehydratase activity
EHC66_RS15860	COG2076	Multidrug Resistance protein
EHC66_RS15870	COG0583	DNA-binding transcription factor activity
EHC66_RS15875	COG1609	Transcriptional regulator
EHC66_RS15915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHC66_RS15925	COG0747	negative chemotaxis
EHC66_RS15930	COG4172	Belongs to the ABC transporter superfamily
EHC66_RS15995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_RS16000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_RS16010	COG2960	long-chain fatty acid transporting porin activity
EHC66_RS16015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EHC66_RS16020	COG0583	DNA-binding transcription factor activity
EHC66_RS16060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EHC66_RS16070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHC66_RS16075	COG0408	coproporphyrinogen oxidase activity
EHC66_RS16080	COG0009	L-threonylcarbamoyladenylate synthase
EHC66_RS16085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EHC66_RS16090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EHC66_RS16095	COG0551	DNA topoisomerase type I activity
EHC66_RS16100	COG2922	Belongs to the Smg family
EHC66_RS16105	COG0758	DNA mediated transformation
EHC66_RS16115	COG0242	peptide deformylase activity
EHC66_RS16120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHC66_RS16125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHC66_RS16125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHC66_RS16130	COG0569	domain protein
EHC66_RS16135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHC66_RS16145	COG1272	protein, Hemolysin III
EHC66_RS16150	COG4326	sporulation control protein
EHC66_RS16160	COG3084	Protein conserved in bacteria
EHC66_RS16170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EHC66_RS16175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHC66_RS16180	COG0204	Acyl-transferase
EHC66_RS16275	COG0606	chelatase, subunit chli
EHC66_RS16285	COG3978	acetolactate synthase activity
EHC66_RS16290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EHC66_RS16295	COG0129	dihydroxy-acid dehydratase activity
EHC66_RS16305	COG0583	DNA-binding transcription factor activity
EHC66_RS16310	COG2814	Major facilitator Superfamily
EHC66_RS16315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_RS16320	COG0765	amino acid transport
EHC66_RS16325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EHC66_RS16330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EHC66_RS16335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EHC66_RS16340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EHC66_RS16345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EHC66_RS16350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EHC66_RS16365	COG0356	it plays a direct role in the translocation of protons across the membrane
EHC66_RS16370	COG3312	ion transport
EHC66_RS16375	COG1475	DNA binding
EHC66_RS16380	COG1192	Involved in chromosome partitioning
EHC66_RS16385	COG0357	Ribosomal RNA small subunit methyltransferase G
EHC66_RS16390	COG0445	tRNA wobble uridine modification
EHC66_RS16395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EHC66_RS16410	COG0464	growth
EHC66_RS16495	COG4974	Belongs to the 'phage' integrase family
EHC66_RS16500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EHC66_RS16505	COG0706	membrane insertase activity
EHC66_RS16510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EHC66_RS16515	COG0594	ribonuclease P activity
EHC66_RS16525	COG1126	abc transporter atp-binding protein
EHC66_RS16565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHC66_RS16570	COG0581	inorganic phosphate transmembrane transporter activity
EHC66_RS16575	COG0573	inorganic phosphate transmembrane transporter activity
EHC66_RS16580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EHC66_RS16605	COG4771	TonB-dependent receptor
EHC66_RS16610	COG1770	oligopeptidase
EHC66_RS16615	COG0513	Belongs to the DEAD box helicase family
EHC66_RS16625	COG1388	LysM domain
EHC66_RS16625	COG1376	ErfK ybiS ycfS ynhG family protein
EHC66_RS16630	COG0415	Belongs to the DNA photolyase family
EHC66_RS16635	COG0789	Transcriptional regulator
EHC66_RS16640	COG3272	Protein of unknown function (DUF1722)
EHC66_RS16650	COG0813	purine-nucleoside phosphorylase activity
EHC66_RS16665	COG3706	GGDEF domain
EHC66_RS16675	COG1566	PFAM secretion protein HlyD family protein
EHC66_RS16680	COG4720	Psort location CytoplasmicMembrane, score
EHC66_RS16685	COG1122	ATPase activity
EHC66_RS16700	COG0348	domain, Protein
EHC66_RS16705	COG0437	4 iron, 4 sulfur cluster binding
EHC66_RS16710	COG1247	-acetyltransferase
EHC66_RS16740	COG1067	ATP-dependent peptidase activity
EHC66_RS16750	COG4172	Belongs to the ABC transporter superfamily
EHC66_RS16755	COG1505	serine-type exopeptidase activity
EHC66_RS16760	COG0583	DNA-binding transcription factor activity
EHC66_RS16765	COG1620	l-lactate permease
EHC66_RS16770	COG1304	FMN binding
EHC66_RS16780	COG0668	transmembrane transport
EHC66_RS16830	COG1063	alcohol dehydrogenase
EHC66_RS16835	COG0156	8-amino-7-oxononanoate synthase activity
EHC66_RS16845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_RS16870	COG0745	RESPONSE REGULATOR receiver
EHC66_RS16905	COG0346	lactoylglutathione lyase activity
EHC66_RS16925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EHC66_RS16965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHC66_RS16980	COG2204	response regulator
EHC66_RS17015	COG1987	bacterial-type flagellum assembly
EHC66_RS17025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EHC66_RS17040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS17050	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EHC66_RS17055	COG1516	flagellar protein fliS
EHC66_RS17070	COG1580	Controls the rotational direction of flagella during chemotaxis
EHC66_RS17075	COG1191	sigma factor activity
EHC66_RS17080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EHC66_RS17085	COG1360	Flagellar Motor Protein
EHC66_RS17120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EHC66_RS17125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHC66_RS17135	COG0454	-acetyltransferase
EHC66_RS17145	COG2814	Major facilitator Superfamily
EHC66_RS17190	COG0628	permease
EHC66_RS17195	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EHC66_RS17205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHC66_RS17215	COG4628	conserved protein (DUF2132)
EHC66_RS17220	COG0583	DNA-binding transcription factor activity
EHC66_RS17245	COG1686	Belongs to the peptidase S11 family
EHC66_RS17265	COG3397	chitin binding
EHC66_RS17270	COG4667	esterase of the alpha-beta hydrolase superfamily
EHC66_RS17275	COG2095	MarC family integral membrane protein
EHC66_RS17295	COG3206	protein involved in exopolysaccharide biosynthesis
EHC66_RS17295	COG0489	protein tyrosine kinase activity
EHC66_RS17310	COG0583	DNA-binding transcription factor activity
EHC66_RS17320	COG1301	dicarboxylic acid transport
EHC66_RS17330	COG3339	Conserved Protein
EHC66_RS17335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHC66_RS17340	COG0700	Nucleoside recognition
EHC66_RS17345	COG3366	ferrous iron transmembrane transporter activity
EHC66_RS17360	COG0366	Alpha amylase catalytic
EHC66_RS17365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHC66_RS17370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EHC66_RS17375	COG1640	4-alpha-glucanotransferase
EHC66_RS17380	COG0058	SHG alpha-glucan phosphorylase activity
EHC66_RS17395	COG2909	trisaccharide binding
EHC66_RS17410	COG1999	signal sequence binding
EHC66_RS17420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_RS17420	COG1263	PTS System
EHC66_RS17425	COG1162	GTPase activity
EHC66_RS17430	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EHC66_RS17440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EHC66_RS17450	COG0531	amino acid
EHC66_RS17455	COG1982	Orn Lys Arg decarboxylase major
EHC66_RS17475	COG2356	endonuclease I
EHC66_RS17500	COG4580	involved in the transport of maltose and maltodextrins
EHC66_RS17525	COG0739	heme binding
EHC66_RS17535	COG0612	Peptidase, M16
EHC66_RS17540	COG0840	transmembrane signaling receptor activity
EHC66_RS17545	COG1120	ATPase activity
EHC66_RS17550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHC66_RS17555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHC66_RS17560	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EHC66_RS17565	COG4772	TonB-dependent receptor
EHC66_RS17590	COG4264	IucA IucC family
EHC66_RS17595	COG0019	diaminopimelate decarboxylase activity
EHC66_RS17600	COG1653	transport
EHC66_RS17610	COG0745	RESPONSE REGULATOR receiver
EHC66_RS17635	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHC66_RS17640	COG1129	ABC transporter
EHC66_RS17645	COG1879	ABC-type sugar transport system periplasmic component
EHC66_RS17650	COG1069	ribulokinase activity
EHC66_RS17660	COG2160	L-arabinose isomerase activity
EHC66_RS17685	COG1764	response to oxidative stress
EHC66_RS17690	COG1846	Transcriptional regulator
EHC66_RS17695	COG0450	alkyl hydroperoxide reductase
EHC66_RS17700	COG3634	alkyl hydroperoxide reductase activity
EHC66_RS17745	COG0840	transmembrane signaling receptor activity
EHC66_RS17750	COG0583	DNA-binding transcription factor activity
EHC66_RS17755	COG1486	melibiose metabolic process
EHC66_RS17770	COG2258	MOSC domain
EHC66_RS17775	COG0513	Belongs to the DEAD box helicase family
EHC66_RS17785	COG2186	Transcriptional regulator
EHC66_RS17795	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EHC66_RS17805	COG0246	Mannitol dehydrogenase
EHC66_RS17810	COG1904	glucuronate isomerase
EHC66_RS17815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_RS17820	COG0800	Aldolase
EHC66_RS17845	COG2207	Transcriptional regulator
EHC66_RS17855	COG1132	(ABC) transporter
EHC66_RS17900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHC66_RS17930	COG0259	pyridoxamine-phosphate oxidase activity
EHC66_RS17975	COG4166	transmembrane transport
EHC66_RS17995	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EHC66_RS18000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_RS18000	COG1263	PTS System
EHC66_RS18005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHC66_RS18010	COG3340	Belongs to the peptidase S51 family
EHC66_RS18030	COG1444	tRNA N-acetyltransferase activity
EHC66_RS18055	COG4608	Belongs to the ABC transporter superfamily
EHC66_RS18060	COG0444	Belongs to the ABC transporter superfamily
EHC66_RS18070	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
EHC66_RS18070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHC66_RS18095	COG0217	transcriptional regulatory protein
EHC66_RS18100	COG0772	Belongs to the SEDS family
EHC66_RS18135	COG3275	phosphorelay sensor kinase activity
EHC66_RS18140	COG3279	Response regulator of the LytR AlgR family
EHC66_RS18150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHC66_RS18185	COG0786	glutamate:sodium symporter activity
EHC66_RS18195	COG1131	(ABC) transporter
EHC66_RS18200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_RS18205	COG0786	glutamate:sodium symporter activity
EHC66_RS18220	COG0363	glucosamine-6-phosphate deaminase activity
EHC66_RS18240	COG1741	Belongs to the pirin family
EHC66_RS18245	COG2259	Doxx family
EHC66_RS18260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EHC66_RS18265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EHC66_RS18275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EHC66_RS18315	COG3123	guanosine phosphorylase activity
EHC66_RS18325	COG5001	Diguanylate cyclase
EHC66_RS18335	COG0534	Mate efflux family protein
EHC66_RS18340	COG0564	pseudouridine synthase activity
EHC66_RS18355	COG0583	DNA-binding transcription factor activity
EHC66_RS18360	COG0561	phosphatase activity
EHC66_RS18370	COG2199	diguanylate cyclase activity
EHC66_RS18385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EHC66_RS18390	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EHC66_RS18395	COG0583	DNA-binding transcription factor activity
EHC66_RS18410	COG1414	Transcriptional regulator
EHC66_RS18415	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS18425	COG1917	Cupin 2, conserved barrel domain protein
EHC66_RS18440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_RS18445	COG0800	Aldolase
EHC66_RS18465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHC66_RS18470	COG0823	Involved in the tonB-independent uptake of proteins
EHC66_RS18475	COG2375	cellular response to nickel ion
EHC66_RS18505	COG1357	PFAM Pentapeptide repeats (8 copies)
EHC66_RS18510	COG3047	cAMP biosynthetic process
EHC66_RS18540	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EHC66_RS18540	COG3408	Glycogen debranching enzyme
EHC66_RS18545	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EHC66_RS18555	COG0583	DNA-binding transcription factor activity
EHC66_RS18565	COG0583	DNA-binding transcription factor activity
EHC66_RS18580	COG0546	phosphoglycolate phosphatase activity
EHC66_RS18605	COG3835	regulator
EHC66_RS18610	COG2610	gluconate transmembrane transporter activity
EHC66_RS18615	COG1929	Belongs to the glycerate kinase type-1 family
EHC66_RS18620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_RS18655	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS18665	COG3005	denitrification pathway
EHC66_RS18670	COG0243	molybdopterin cofactor binding
EHC66_RS18680	COG0352	thiamine-phosphate diphosphorylase activity
EHC66_RS18685	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EHC66_RS18690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EHC66_RS18695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHC66_RS18700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHC66_RS18705	COG1116	anion transmembrane transporter activity
EHC66_RS18710	COG0351	phosphomethylpyrimidine kinase
EHC66_RS18720	COG0312	modulator of DNA gyrase
EHC66_RS18725	COG0312	modulator of DNA gyrase
EHC66_RS18730	COG1901	pseudouridine methyltransferase
EHC66_RS18790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHC66_RS18800	COG0584	glycerophosphoryl diester phosphodiesterase
EHC66_RS18810	COG0745	RESPONSE REGULATOR receiver
EHC66_RS18830	COG0811	peptide transport
EHC66_RS18835	COG0811	peptide transport
EHC66_RS18840	COG0848	biopolymer transport protein
EHC66_RS18885	COG0803	Belongs to the bacterial solute-binding protein 9 family
EHC66_RS18890	COG1121	(ABC) transporter
EHC66_RS18895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHC66_RS18910	COG1770	oligopeptidase
EHC66_RS18915	COG2814	Major facilitator Superfamily
EHC66_RS18920	COG0010	Belongs to the arginase family
EHC66_RS18925	COG1166	arginine decarboxylase activity
EHC66_RS18935	COG4067	protein conserved in archaea
EHC66_RS18935	COG0189	ligase activity
EHC66_RS18940	COG0189	ligase activity
EHC66_RS18945	COG0583	DNA-binding transcription factor activity
EHC66_RS18990	COG3706	GGDEF domain
EHC66_RS19020	COG0579	oxidoreductase
EHC66_RS19030	COG3033	Beta-eliminating lyase
EHC66_RS19050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHC66_RS19065	COG3706	GGDEF domain
EHC66_RS19070	COG0840	transmembrane signaling receptor activity
EHC66_RS19085	COG3706	GGDEF domain
EHC66_RS19090	COG0415	Belongs to the DNA photolyase family
EHC66_RS19095	COG3046	protein related to deoxyribodipyrimidine photolyase
EHC66_RS19110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHC66_RS19110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHC66_RS19115	COG1765	OsmC-like protein
EHC66_RS19120	COG0110	maltose O-acetyltransferase activity
EHC66_RS19160	COG1011	Hydrolase
EHC66_RS19175	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EHC66_RS19185	COG2067	long-chain fatty acid transport protein
EHC66_RS19190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_RS19195	COG1136	(ABC) transporter
EHC66_RS19195	COG0577	efflux transmembrane transporter activity
EHC66_RS19205	COG3240	lipase activity
EHC66_RS19230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS19235	COG1609	Transcriptional regulator
EHC66_RS19240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHC66_RS19255	COG1840	ABC-type Fe3 transport system, periplasmic component
EHC66_RS19265	COG3842	ATPase activity
EHC66_RS19290	COG2990	Protein conserved in bacteria
EHC66_RS19300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHC66_RS19305	COG2866	Carboxypeptidase
EHC66_RS19320	COG0583	DNA-binding transcription factor activity
EHC66_RS19345	COG1760	l-serine dehydratase
EHC66_RS19365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHC66_RS19370	COG0741	lytic transglycosylase activity
EHC66_RS19390	COG1815	bacterial-type flagellum-dependent cell motility
EHC66_RS19395	COG1558	bacterial-type flagellum-dependent cell motility
EHC66_RS19400	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EHC66_RS19405	COG1749	Flagellar hook protein flgE
EHC66_RS19410	COG4787	bacterial-type flagellum-dependent cell motility
EHC66_RS19415	COG4786	Flagellar basal body rod
EHC66_RS19420	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EHC66_RS19425	COG1706	bacterial-type flagellum-dependent cell motility
EHC66_RS19435	COG1256	bacterial-type flagellum assembly
EHC66_RS19435	COG4786	Flagellar basal body rod
EHC66_RS19440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_RS19460	COG1304	FMN binding
EHC66_RS19505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHC66_RS19510	COG0459	protein refolding
EHC66_RS19525	COG1280	lysine exporter protein (LysE YggA)
EHC66_RS19545	COG1309	transcriptional regulator
EHC66_RS19555	COG0737	Belongs to the 5'-nucleotidase family
EHC66_RS19560	COG2070	2-Nitropropane dioxygenase
EHC66_RS19565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_RS19575	COG0583	DNA-binding transcription factor activity
EHC66_RS19590	COG0346	lactoylglutathione lyase activity
EHC66_RS19595	COG1349	DNA-binding transcription factor activity
EHC66_RS19605	COG0753	catalase activity
EHC66_RS19615	COG1335	isochorismatase
EHC66_RS19625	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EHC66_RS19650	COG0583	DNA-binding transcription factor activity
EHC66_RS19665	COG3713	MltA-interacting MipA family protein
EHC66_RS19675	COG3015	lipoprotein NlpE involved in copper resistance
EHC66_RS19685	COG1342	Belongs to the UPF0251 family
EHC66_RS19710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHC66_RS19720	COG4948	Mandelate Racemase Muconate Lactonizing
EHC66_RS19730	COG0583	DNA-binding transcription factor activity
EHC66_RS19780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHC66_RS19825	COG3842	ATPase activity
EHC66_RS19855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHC66_RS19875	COG3706	GGDEF domain
EHC66_RS19895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_RS19910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EHC66_RS19915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EHC66_RS19935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHC66_RS19935	COG0574	Belongs to the PEP-utilizing enzyme family
EHC66_RS19940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EHC66_RS19945	COG0252	asparaginase activity
EHC66_RS19955	COG0583	DNA-binding transcription factor activity
EHC66_RS19970	COG3122	Protein conserved in bacteria
EHC66_RS19985	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS19995	COG1063	alcohol dehydrogenase
EHC66_RS20000	COG1902	pentaerythritol trinitrate reductase activity
EHC66_RS20015	COG0583	DNA-binding transcription factor activity
EHC66_RS20025	COG0513	Belongs to the DEAD box helicase family
EHC66_RS20040	COG3423	Transcriptional regulator
EHC66_RS20045	COG2801	Transposase and inactivated derivatives
EHC66_RS20055	COG2842	Transposition protein
EHC66_RS20135	COG5566	PFAM Mor transcription activator
EHC66_RS20165	COG0640	Transcriptional regulator
EHC66_RS20175	COG4373	Mu-like prophage FluMu protein gp28
EHC66_RS20180	COG4383	Mu-like prophage protein gp29
EHC66_RS20200	COG4388	Caudovirus prohead serine protease
EHC66_RS20210	COG4397	Mu-like prophage major head subunit gpT
EHC66_RS20220	COG4387	Mu-like prophage protein GP36
EHC66_RS20320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_RS20325	COG2207	Transcriptional regulator
EHC66_RS20325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHC66_RS20355	COG2354	Protein conserved in bacteria
EHC66_RS20360	COG0418	dihydroorotase activity
EHC66_RS20370	COG0401	homolog of Blt101
EHC66_RS20380	COG3217	Mosc domain protein beta barrel domain protein
EHC66_RS20380	COG0633	Ferredoxin
EHC66_RS20380	COG3217	Mosc domain protein beta barrel domain protein
EHC66_RS20380	COG0633	Ferredoxin
EHC66_RS20385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EHC66_RS20390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EHC66_RS20430	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHC66_RS20435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHC66_RS20445	COG0848	biopolymer transport protein
EHC66_RS20450	COG0811	peptide transport
EHC66_RS20455	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EHC66_RS20465	COG3721	Heme iron utilization protein
EHC66_RS20470	COG0748	coenzyme F420 binding
EHC66_RS20480	COG0784	Response regulator, receiver
EHC66_RS20480	COG0835	chemotaxis
EHC66_RS20490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHC66_RS20500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EHC66_RS20500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHC66_RS20525	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EHC66_RS20530	COG0783	Belongs to the Dps family
EHC66_RS20540	COG0583	DNA-binding transcription factor activity
EHC66_RS20560	COG0641	radical SAM
EHC66_RS20575	COG4934	collagen metabolic process
EHC66_RS20585	COG0366	Alpha amylase catalytic
EHC66_RS20605	COG2249	NAD(P)H dehydrogenase (quinone) activity
EHC66_RS20610	COG0589	response to stress
EHC66_RS20615	COG0488	(ABC) transporter
EHC66_RS20620	COG1505	serine-type exopeptidase activity
EHC66_RS20640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_RS20650	COG2067	long-chain fatty acid transport protein
EHC66_RS20660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHC66_RS20670	COG2199	diguanylate cyclase activity
EHC66_RS20670	COG2203	Gaf domain
EHC66_RS20690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_RS20715	COG3383	formate dehydrogenase (NAD+) activity
EHC66_RS20730	COG0842	Transport permease protein
EHC66_RS20735	COG1131	(ABC) transporter
EHC66_RS20745	COG0840	transmembrane signaling receptor activity
EHC66_RS20750	COG2706	6-phosphogluconolactonase activity
EHC66_RS20760	COG1881	PFAM PEBP family protein
EHC66_RS20770	COG0798	PFAM Bile acid sodium symporter
EHC66_RS20790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS20795	COG2213	PTS system mannitol-specific
EHC66_RS20800	COG1063	alcohol dehydrogenase
EHC66_RS20810	COG1072	(Pantothenic acid kinase))
EHC66_RS20815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EHC66_RS20835	COG0814	amino acid
EHC66_RS20875	COG0739	heme binding
EHC66_RS20880	COG5001	Diguanylate cyclase
EHC66_RS20885	COG0583	DNA-binding transcription factor activity
EHC66_RS20890	COG2814	Major facilitator Superfamily
EHC66_RS20915	COG0697	spore germination
EHC66_RS20945	COG2207	Transcriptional regulator
EHC66_RS20950	COG1280	lysine exporter protein (LysE YggA)
EHC66_RS20960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHC66_RS20965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHC66_RS20975	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EHC66_RS21000	COG1612	heme a metabolic process
EHC66_RS21005	COG0109	protoheme IX farnesyltransferase activity
EHC66_RS21010	COG0545	Peptidyl-prolyl cis-trans isomerase
EHC66_RS21045	COG1278	Cold shock
EHC66_RS21050	COG3036	rescue of stalled ribosome
EHC66_RS21065	COG2199	diguanylate cyclase activity
EHC66_RS21085	COG1136	(ABC) transporter
EHC66_RS21085	COG0577	efflux transmembrane transporter activity
EHC66_RS21095	COG0840	transmembrane signaling receptor activity
EHC66_RS21100	COG0783	Belongs to the Dps family
EHC66_RS21110	COG2133	pyrroloquinoline quinone binding
EHC66_RS21115	COG1454	alcohol dehydrogenase
EHC66_RS21120	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EHC66_RS21160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHC66_RS21165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHC66_RS21170	COG3186	Phenylalanine-4-hydroxylase
EHC66_RS21175	COG2154	pterin-4-alpha-carbinolamine dehydratase
EHC66_RS21200	COG3530	Putative quorum-sensing-regulated virulence factor
EHC66_RS21205	COG0513	Belongs to the DEAD box helicase family
EHC66_RS21210	COG4628	conserved protein (DUF2132)
EHC66_RS21215	COG0133	tryptophan synthase activity
EHC66_RS21225	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EHC66_RS21235	COG0523	cobalamin synthesis protein
EHC66_RS21240	COG0513	Belongs to the DEAD box helicase family
EHC66_RS21260	COG2200	EAL domain
EHC66_RS21265	COG1119	ATPase activity
EHC66_RS21270	COG0840	transmembrane signaling receptor activity
EHC66_RS21295	COG0641	radical SAM
EHC66_RS21330	COG0582	viral genome integration into host DNA
EHC66_RS21375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EHC66_RS21390	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EHC66_RS21395	COG0513	Belongs to the DEAD box helicase family
EHC66_RS21400	COG5001	Diguanylate cyclase
EHC66_RS21410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHC66_RS21425	COG5413	integral membrane protein
EHC66_RS21435	COG1024	Enoyl-CoA hydratase
EHC66_RS21440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHC66_RS21445	COG1960	acyl-CoA dehydrogenase activity
EHC66_RS21455	COG0183	Belongs to the thiolase family
EHC66_RS21470	COG1024	Enoyl-CoA hydratase
EHC66_RS21475	COG1024	Enoyl-CoA hydratase
EHC66_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS21490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHC66_RS21495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHC66_RS21500	COG1845	cytochrome c oxidase, subunit III
EHC66_RS21505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EHC66_RS21510	COG0109	protoheme IX farnesyltransferase activity
EHC66_RS21525	COG1902	pentaerythritol trinitrate reductase activity
EHC66_RS21535	COG1126	abc transporter atp-binding protein
EHC66_RS21540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_RS21545	COG4215	(ABC) transporter
EHC66_RS21550	COG4160	amino acid transport
EHC66_RS21565	COG0625	glutathione transferase activity
EHC66_RS21605	COG0443	Heat shock 70 kDa protein
EHC66_RS21610	COG2847	Copper chaperone PCu(A)C
EHC66_RS21635	COG4607	ABC-type enterochelin transport system periplasmic component
EHC66_RS21640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHC66_RS21645	COG4605	iron ion homeostasis
EHC66_RS21650	COG4604	ABC transporter, ATP-binding protein
EHC66_RS21655	COG0789	Transcriptional regulator
EHC66_RS21670	COG1629	transport
EHC66_RS21670	COG4771	TonB-dependent receptor
EHC66_RS21705	COG1289	transmembrane transporter activity
EHC66_RS21710	COG0210	DNA helicase
EHC66_RS21715	COG1803	Methylglyoxal synthase
EHC66_RS21720	COG1879	ABC-type sugar transport system periplasmic component
EHC66_RS21725	COG2205	protein histidine kinase activity
EHC66_RS21725	COG2198	Histidine kinase
EHC66_RS21725	COG0784	Response regulator, receiver
EHC66_RS21740	COG0745	RESPONSE REGULATOR receiver
EHC66_RS21745	COG3119	arylsulfatase activity
EHC66_RS21750	COG3119	arylsulfatase activity
EHC66_RS21765	COG3119	arylsulfatase activity
EHC66_RS21770	COG0641	radical SAM
EHC66_RS21775	COG0714	Associated with various cellular activities
EHC66_RS21805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHC66_RS21810	COG0583	DNA-binding transcription factor activity
EHC66_RS21815	COG1597	lipid kinase activity
EHC66_RS21820	COG3111	PFAM Bacterial OB fold (BOF) protein
EHC66_RS21840	COG0641	radical SAM
EHC66_RS21870	COG0501	Belongs to the peptidase M48B family
EHC66_RS21875	COG1704	LemA family
EHC66_RS21880	COG3069	C4-dicarboxylate transmembrane transporter activity
EHC66_RS21890	COG1214	PFAM Peptidase M22, glycoprotease
EHC66_RS21890	COG0456	acetyltransferase
EHC66_RS21910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EHC66_RS21935	COG2207	Transcriptional regulator
EHC66_RS21960	COG4964	Belongs to the GSP D family
EHC66_RS22030	COG0583	DNA-binding transcription factor activity
EHC66_RS22035	COG0583	DNA-binding transcription factor activity
EHC66_RS22050	COG3300	MHYT domain
EHC66_RS22050	COG5001	Diguanylate cyclase
EHC66_RS22055	COG2197	response regulator
EHC66_RS22060	COG3706	GGDEF domain
EHC66_RS22070	COG2197	response regulator
EHC66_RS22095	COG0835	chemotaxis
EHC66_RS22095	COG0784	Response regulator, receiver
EHC66_RS22115	COG2962	Rard protein
EHC66_RS22130	COG0671	phosphoesterase, PA-phosphatase related
EHC66_RS22145	COG2076	Multidrug Resistance protein
EHC66_RS22175	COG0471	metal ion transport
EHC66_RS22180	COG3290	protein histidine kinase activity
EHC66_RS22185	COG4565	transcriptional regulatory protein
EHC66_RS22195	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EHC66_RS22195	COG0069	glutamate synthase activity
EHC66_RS22205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EHC66_RS22230	COG1902	pentaerythritol trinitrate reductase activity
EHC66_RS22235	COG0346	lactoylglutathione lyase activity
EHC66_RS22255	COG2239	Acts as a magnesium transporter
EHC66_RS22285	COG0242	peptide deformylase activity
EHC66_RS22335	COG2176	DNA-directed DNA polymerase activity
EHC66_RS22340	COG0583	DNA-binding transcription factor activity
EHC66_RS22345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EHC66_RS22385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHC66_RS22385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHC66_RS22390	COG0509	glycine decarboxylation via glycine cleavage system
EHC66_RS22395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHC66_RS22435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_RS22435	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EHC66_RS22435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_RS22440	COG1105	Belongs to the carbohydrate kinase PfkB family
EHC66_RS22445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS22445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS22450	COG1609	Transcriptional regulator
EHC66_RS22470	COG2199	diguanylate cyclase activity
EHC66_RS22470	COG2203	Gaf domain
EHC66_RS22470	COG2200	EAL domain
EHC66_RS22475	COG0765	amino acid transport
EHC66_RS22480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_RS22485	COG0765	amino acid transport
EHC66_RS22490	COG1126	abc transporter atp-binding protein
EHC66_RS22495	COG0469	pyruvate kinase activity
EHC66_RS22500	COG2271	Major facilitator Superfamily
EHC66_RS22505	COG1840	ABC-type Fe3 transport system, periplasmic component
EHC66_RS22525	COG1979	alcohol dehydrogenase
EHC66_RS22530	COG2207	Transcriptional regulator
EHC66_RS22545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EHC66_RS22550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EHC66_RS22555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_RS22575	COG0784	Response regulator, receiver
EHC66_RS22575	COG3437	response regulator, receiver
EHC66_RS22585	COG0546	phosphoglycolate phosphatase activity
EHC66_RS22590	COG0840	transmembrane signaling receptor activity
EHC66_RS22600	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EHC66_RS22605	COG0513	Belongs to the DEAD box helicase family
EHC66_RS22610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EHC66_RS22625	COG3038	cytochrome b561
EHC66_RS22630	COG2353	YceI-like domain
EHC66_RS22635	COG2116	formate transmembrane transporter activity
EHC66_RS22640	COG0583	DNA-binding transcription factor activity
EHC66_RS22650	COG3593	DNA synthesis involved in DNA repair
EHC66_RS22655	COG0737	Belongs to the 5'-nucleotidase family
EHC66_RS22660	COG0861	Integral membrane protein TerC family
EHC66_RS22675	COG2267	carboxylic ester hydrolase activity
EHC66_RS22680	COG2067	long-chain fatty acid transport protein
EHC66_RS22695	COG2050	protein possibly involved in aromatic compounds catabolism
EHC66_RS22705	COG4533	DNA binding
EHC66_RS22730	COG0484	heat shock protein binding
EHC66_RS22740	COG3300	MHYT domain
EHC66_RS22740	COG5001	Diguanylate cyclase
EHC66_RS22745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EHC66_RS22755	COG4181	ATPase activity
EHC66_RS22760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EHC66_RS22765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHC66_RS22765	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EHC66_RS22770	COG1984	allophanate hydrolase subunit 2
EHC66_RS22775	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHC66_RS22780	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EHC66_RS22785	COG3447	MASE1 domain protein
EHC66_RS22785	COG5001	Diguanylate cyclase
EHC66_RS22785	COG5002	protein histidine kinase activity
EHC66_RS22790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EHC66_RS22800	COG4771	TonB-dependent receptor
EHC66_RS22800	COG1629	transport
EHC66_RS22805	COG0583	DNA-binding transcription factor activity
EHC66_RS22810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHC66_RS22810	COG1042	CoA-binding domain protein
EHC66_RS22810	COG0045	succinate-CoA ligase (ADP-forming) activity
EHC66_RS22820	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHC66_RS22830	COG0023	Translation Initiation Factor
EHC66_RS22905	COG0583	DNA-binding transcription factor activity
EHC66_RS22915	COG0589	response to stress
EHC66_RS22920	COG3140	Belongs to the UPF0181 family
EHC66_RS22945	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EHC66_RS22950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EHC66_RS22965	COG3706	GGDEF domain
EHC66_RS22965	COG0745	RESPONSE REGULATOR receiver
EHC66_RS22975	COG5001	Diguanylate cyclase
EHC66_RS22975	COG4251	negative regulation of phosphorylation
EHC66_RS22975	COG2203	Gaf domain
EHC66_RS22975	COG3706	GGDEF domain
EHC66_RS22985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EHC66_RS22990	COG4149	molybdate abc transporter
EHC66_RS22995	COG0725	ABC transporter, periplasmic molybdate-binding protein
EHC66_RS23000	COG1492	cobalamin metabolic process
EHC66_RS23005	COG3111	PFAM Bacterial OB fold (BOF) protein
EHC66_RS23015	COG0189	ligase activity
EHC66_RS23015	COG4067	protein conserved in archaea
EHC66_RS23035	COG0534	Mate efflux family protein
EHC66_RS23040	COG0602	queuosine metabolic process
EHC66_RS23045	COG1328	CTP reductase activity
EHC66_RS23060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_RS23085	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHC66_RS23090	COG0243	molybdopterin cofactor binding
EHC66_RS23100	COG0583	DNA-binding transcription factor activity
EHC66_RS23105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EHC66_RS23115	COG2197	response regulator
EHC66_RS23120	COG3851	Histidine kinase
EHC66_RS23125	COG2271	Major facilitator Superfamily
EHC66_RS23150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHC66_RS23155	COG3118	belongs to the thioredoxin family
EHC66_RS23160	COG2814	Major facilitator Superfamily
EHC66_RS23170	COG0534	Mate efflux family protein
EHC66_RS23200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EHC66_RS23220	COG2116	formate transmembrane transporter activity
EHC66_RS23225	COG2146	nitrite reductase [NAD(P)H] activity
EHC66_RS23230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHC66_RS23235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHC66_RS23275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHC66_RS23275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHC66_RS23320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHC66_RS23340	COG0277	FAD linked oxidase domain protein
EHC66_RS23395	COG1288	antiporter activity
EHC66_RS23405	COG2814	Major facilitator Superfamily
EHC66_RS23415	COG3040	lipid binding
EHC66_RS23435	COG0419	ATPase involved in DNA repair
EHC66_RS23440	COG0420	3'-5' exonuclease activity
EHC66_RS23455	COG3501	Rhs element vgr protein
EHC66_RS23525	COG0631	protein serine/threonine phosphatase activity
EHC66_RS23560	COG2815	serine threonine protein kinase
EHC66_RS23560	COG0515	serine threonine protein kinase
EHC66_RS23615	COG2146	nitrite reductase [NAD(P)H] activity
EHC66_RS23615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHC66_RS23620	COG1116	anion transmembrane transporter activity
EHC66_RS23625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHC66_RS23630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHC66_RS23640	COG3707	response regulator
EHC66_RS23660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHC66_RS23660	COG1648	precorrin-2 dehydrogenase activity
EHC66_RS23665	COG0243	molybdopterin cofactor binding
EHC66_RS23670	COG0456	acetyltransferase
EHC66_RS23675	COG0814	amino acid
EHC66_RS23685	COG3706	GGDEF domain
EHC66_RS23685	COG0745	RESPONSE REGULATOR receiver
EHC66_RS23705	COG1785	Belongs to the alkaline phosphatase family
EHC66_RS23720	COG0745	RESPONSE REGULATOR receiver
EHC66_RS23740	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EHC66_RS23755	COG1609	Transcriptional regulator
EHC66_RS23760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_RS23765	COG1879	ABC-type sugar transport system periplasmic component
EHC66_RS23770	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHC66_RS23775	COG1129	ABC transporter
EHC66_RS23780	COG1869	D-ribose catabolic process
EHC66_RS23785	COG5001	Diguanylate cyclase
EHC66_RS23790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHC66_RS23850	COG2205	protein histidine kinase activity
EHC66_RS23850	COG0784	Response regulator, receiver
EHC66_RS23870	COG5001	Diguanylate cyclase
EHC66_RS23870	COG3300	MHYT domain
EHC66_RS23880	COG0330	HflC and HflK could
EHC66_RS23895	COG4175	Glycine betaine
EHC66_RS23895	COG0517	IMP dehydrogenase activity
EHC66_RS23900	COG4176	ABC-type proline glycine betaine transport system permease component
EHC66_RS23920	COG1309	transcriptional regulator
EHC66_RS23925	COG3706	GGDEF domain
EHC66_RS23950	COG1024	Enoyl-CoA hydratase
EHC66_RS23955	COG1960	acyl-CoA dehydrogenase activity
EHC66_RS23965	COG0183	Belongs to the thiolase family
EHC66_RS23975	COG1960	acyl-CoA dehydrogenase activity
EHC66_RS23980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHC66_RS24000	COG2205	protein histidine kinase activity
EHC66_RS24000	COG3850	Histidine kinase
EHC66_RS24000	COG4999	Histidine kinase
EHC66_RS24000	COG3437	response regulator, receiver
EHC66_RS24015	COG3264	Mechanosensitive ion channel
EHC66_RS24015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EHC66_RS24025	COG0110	maltose O-acetyltransferase activity
EHC66_RS24030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_RS24035	COG1271	oxidase subunit
EHC66_RS24040	COG1294	oxidase, subunit
EHC66_RS24050	COG0384	phenazine biosynthesis protein PhzF
EHC66_RS24055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHC66_RS24060	COG0789	Transcriptional regulator
EHC66_RS24070	COG3474	cytochrome
EHC66_RS24080	COG0500	methyltransferase
EHC66_RS24140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHC66_RS24265	COG2356	endonuclease I
EHC66_RS24355	COG1683	Conserved Protein
EHC66_RS24375	COG2026	Addiction module toxin, RelE StbE family
EHC66_RS24380	COG4115	mRNA cleavage
EHC66_RS24385	COG2161	toxin-antitoxin pair type II binding
EHC66_RS24405	COG0494	nUDIX hydrolase
EHC66_RS24435	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_RS24450	COG2199	diguanylate cyclase activity
EHC66_RS24450	COG2200	EAL domain
EHC66_RS24450	COG2202	Pas domain
EHC66_RS24475	COG0840	transmembrane signaling receptor activity
EHC66_RS24490	COG0840	transmembrane signaling receptor activity
EHC66_RS24545	COG0464	growth
EHC66_RS24550	COG4974	Belongs to the 'phage' integrase family
EHC66_RS24555	COG0516	GMP reductase activity
EHC66_RS24560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EHC66_RS24560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EHC66_RS24575	COG4989	oxidoreductase activity
EHC66_RS24590	COG0038	chloride channel
EHC66_RS24600	COG1914	H( )-stimulated, divalent metal cation uptake system
EHC66_RS24605	COG0302	gtp cyclohydrolase
EHC66_RS24615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EHC66_RS24635	COG2897	thiosulfate sulfurtransferase activity
EHC66_RS24660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHC66_RS24665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHC66_RS24670	COG0840	transmembrane signaling receptor activity
EHC66_RS24680	COG2814	Major facilitator Superfamily
EHC66_RS24685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHC66_RS24695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHC66_RS24705	COG0840	transmembrane signaling receptor activity
EHC66_RS24725	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHC66_RS24740	COG2197	response regulator
EHC66_RS24745	COG3850	Histidine kinase
EHC66_RS24750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EHC66_RS24760	COG0243	molybdopterin cofactor binding
EHC66_RS24770	COG3005	denitrification pathway
EHC66_RS24790	COG0183	Belongs to the thiolase family
EHC66_RS24810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHC66_RS24815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHC66_RS24840	COG1522	sequence-specific DNA binding
EHC66_RS24860	COG1566	PFAM secretion protein HlyD family protein
EHC66_RS24870	COG0784	Response regulator, receiver
EHC66_RS24870	COG2205	protein histidine kinase activity
EHC66_RS24875	COG1879	ABC-type sugar transport system periplasmic component
EHC66_RS24880	COG2827	Endonuclease containing a URI domain
EHC66_RS24885	COG3132	Protein of unknown function, DUF480
EHC66_RS24900	COG2926	Belongs to the UPF0265 family
EHC66_RS24905	COG0534	Mate efflux family protein
EHC66_RS24910	COG0673	inositol 2-dehydrogenase activity
EHC66_RS24915	COG2205	protein histidine kinase activity
EHC66_RS24915	COG0784	Response regulator, receiver
EHC66_RS24915	COG5002	protein histidine kinase activity
EHC66_RS24940	COG1522	sequence-specific DNA binding
EHC66_RS24950	COG0531	amino acid
EHC66_RS24965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EHC66_RS24970	COG2239	Acts as a magnesium transporter
EHC66_RS24975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EHC66_RS24980	COG0402	S-adenosylhomocysteine deaminase activity
EHC66_RS24990	COG1418	mRNA catabolic process
EHC66_RS25005	COG2814	Major facilitator Superfamily
EHC66_RS25015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHC66_RS25035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHC66_RS25055	COG4221	oxidoreductase activity
EHC66_RS25060	COG0745	RESPONSE REGULATOR receiver
EHC66_RS25065	COG2205	protein histidine kinase activity
EHC66_RS25075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EHC66_RS25080	COG2194	sulfuric ester hydrolase activity
EHC66_RS25085	COG0673	inositol 2-dehydrogenase activity
EHC66_RS25095	COG2814	Major facilitator Superfamily
EHC66_RS25110	COG1846	Transcriptional regulator
EHC66_RS25120	COG4667	esterase of the alpha-beta hydrolase superfamily
EHC66_RS25125	COG1741	Belongs to the pirin family
EHC66_RS25130	COG1278	Cold shock
EHC66_RS25145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EHC66_RS25165	COG1686	Belongs to the peptidase S11 family
EHC66_RS25175	COG0625	glutathione transferase activity
EHC66_RS25185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EHC66_RS25190	COG0494	nUDIX hydrolase
EHC66_RS25195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHC66_RS25215	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_RS25235	COG3746	phosphate-selective porin O and P
EHC66_RS25255	COG3833	ABC-type maltose transport systems, permease component
EHC66_RS25260	COG1175	transmembrane transport
EHC66_RS25270	COG3842	ATPase activity
EHC66_RS25335	COG1309	transcriptional regulator
EHC66_RS25340	COG2130	NADP-dependent
EHC66_RS25350	COG0753	catalase activity
EHC66_RS25355	COG2084	Dehydrogenase
EHC66_RS25360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_RS25365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_RS25375	COG2207	Transcriptional regulator
EHC66_RS25380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_RS25380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_RS25380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_RS25395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHC66_RS25400	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
EHC66_RS25410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHC66_RS25415	COG0569	domain protein
EHC66_RS25425	COG5002	protein histidine kinase activity
EHC66_RS25430	COG1132	(ABC) transporter
EHC66_RS25435	COG4774	siderophore transport
EHC66_RS25440	COG1120	ATPase activity
EHC66_RS25445	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EHC66_RS25460	COG2885	chlorophyll binding
EHC66_RS25460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHC66_RS25500	COG2197	response regulator
EHC66_RS25510	COG0840	transmembrane signaling receptor activity
EHC66_RS25520	COG0714	Associated with various cellular activities
EHC66_RS25700	COG0739	heme binding
EHC66_RS25715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EHC66_RS25735	COG4932	domain protein
EHC66_RS25735	COG5492	domain, Protein
EHC66_RS25755	COG4974	Belongs to the 'phage' integrase family
EHC66_RS25765	COG2337	Toxic component of a toxin-antitoxin (TA) module
EHC66_RS25820	COG2885	chlorophyll binding
EHC66_RS25860	COG5492	domain, Protein
EHC66_RS25860	COG4932	domain protein
EHC66_RS25890	COG1192	Involved in chromosome partitioning
EHC66_RS25955	COG3451	type IV secretory pathway VirB4
EHC66_RS25975	COG3701	Conjugal transfer protein
EHC66_RS25990	COG2948	multi-organism process
EHC66_RS26000	COG2885	chlorophyll binding
EHC66_RS26000	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHC66_RS26025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHC66_RS26135	COG3504	Conjugal transfer protein
EHC66_RS26150	COG4962	Type ii secretion system protein e
EHC66_RS26160	COG3451	type IV secretory pathway VirB4
EHC66_RS26165	COG5268	conjugation
EHC66_RS26190	COG1192	Involved in chromosome partitioning
EHC66_RS26215	COG0419	ATPase involved in DNA repair