locus-tag	class	description
GPY25_RS00010	COG0191	fructose-bisphosphate aldolase activity
GPY25_RS00015	COG0126	phosphoglycerate kinase activity
GPY25_RS00020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY25_RS00025	COG4771	TonB-dependent receptor
GPY25_RS00030	COG0583	DNA-binding transcription factor activity
GPY25_RS00035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY25_RS00045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY25_RS00055	COG3091	SprT-like family
GPY25_RS00060	COG2356	endonuclease I
GPY25_RS00065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY25_RS00070	COG0189	ligase activity
GPY25_RS00075	COG1678	Uncharacterized ACR, COG1678
GPY25_RS00080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY25_RS00095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY25_RS00100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY25_RS00105	COG0762	integral membrane protein
GPY25_RS00110	COG1872	DUF167
GPY25_RS00120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY25_RS00125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY25_RS00130	COG2066	Belongs to the glutaminase family
GPY25_RS00140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY25_RS00150	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY25_RS00155	COG0741	lytic transglycosylase activity
GPY25_RS00225	COG1012	belongs to the aldehyde dehydrogenase family
GPY25_RS00275	COG3437	response regulator, receiver
GPY25_RS00285	COG3394	polysaccharide catabolic process
GPY25_RS00290	COG1486	melibiose metabolic process
GPY25_RS00295	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY25_RS00300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY25_RS00305	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY25_RS00310	COG0726	polysaccharide deacetylase
GPY25_RS00325	COG4325	translation initiation factor activity
GPY25_RS00335	COG0795	lipopolysaccharide-transporting ATPase activity
GPY25_RS00340	COG0795	lipopolysaccharide-transporting ATPase activity
GPY25_RS00345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY25_RS00350	COG2927	DNA polymerase III (CHI subunit)
GPY25_RS00355	COG0525	valine-tRNA ligase activity
GPY25_RS00385	COG2235	arginine
GPY25_RS00390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY25_RS00400	COG0540	Belongs to the ATCase OTCase family
GPY25_RS00405	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY25_RS00410	COG0251	oxidation-reduction process
GPY25_RS00415	COG0204	Acyl-transferase
GPY25_RS00420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY25_RS00425	COG5007	Belongs to the BolA IbaG family
GPY25_RS00435	COG2854	intermembrane phospholipid transfer
GPY25_RS00440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY25_RS00445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY25_RS00450	COG1127	ABC transporter
GPY25_RS00460	COG0517	IMP dehydrogenase activity
GPY25_RS00460	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY25_RS00470	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY25_RS00475	COG1137	ATPase activity
GPY25_RS00485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY25_RS00490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY25_RS00495	COG1660	Displays ATPase and GTPase activities
GPY25_RS00500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY25_RS00505	COG2239	Acts as a magnesium transporter
GPY25_RS00510	COG0312	modulator of DNA gyrase
GPY25_RS00515	COG3028	Belongs to the UPF0307 family
GPY25_RS00520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY25_RS00525	COG0564	pseudouridine synthase activity
GPY25_RS00540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY25_RS00545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY25_RS00550	COG0312	modulator of DNA gyrase
GPY25_RS00555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY25_RS00560	COG3164	Protein of unknown function
GPY25_RS00565	COG1530	ribonuclease E activity
GPY25_RS00570	COG0424	maF-like protein
GPY25_RS00575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY25_RS00580	COG1792	Involved in formation and maintenance of cell shape
GPY25_RS00585	COG1077	Cell shape determining protein MreB Mrl
GPY25_RS00630	COG1459	type II secretion system
GPY25_RS00635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY25_RS00645	COG3267	Type II secretory pathway component ExeA
GPY25_RS00645	COG3409	Peptidoglycan-binding domain 1 protein
GPY25_RS00670	COG2199	diguanylate cyclase activity
GPY25_RS00670	COG2200	EAL domain
GPY25_RS00675	COG0629	single-stranded DNA binding
GPY25_RS00690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY25_RS00700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY25_RS00705	COG0527	aspartate kinase activity
GPY25_RS00710	COG0646	methionine synthase
GPY25_RS00710	COG1410	methionine synthase
GPY25_RS00785	COG0175	sulfate reduction
GPY25_RS00790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY25_RS00795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY25_RS00820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY25_RS00830	COG0735	belongs to the Fur family
GPY25_RS00840	COG0166	Belongs to the GPI family
GPY25_RS00845	COG0432	Pfam Uncharacterised protein family UPF0047
GPY25_RS00855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY25_RS00860	COG0305	Participates in initiation and elongation during chromosome replication
GPY25_RS00870	COG0359	binds to the 23S rRNA
GPY25_RS00880	COG2965	DNA replication, synthesis of RNA primer
GPY25_RS00885	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY25_RS00890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY25_RS00895	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY25_RS00905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY25_RS00910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY25_RS00940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY25_RS00950	COG0678	peroxiredoxin activity
GPY25_RS00950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY25_RS00965	COG0165	Argininosuccinate lyase
GPY25_RS00965	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY25_RS00970	COG0137	argininosuccinate synthase activity
GPY25_RS00975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY25_RS00980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY25_RS00985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY25_RS00990	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY25_RS00995	COG1695	Transcriptional regulator
GPY25_RS01000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY25_RS01005	COG0460	homoserine dehydrogenase
GPY25_RS01005	COG0527	aspartate kinase activity
GPY25_RS01010	COG0626	cystathionine gamma-synthase activity
GPY25_RS01020	COG0281	malic enzyme
GPY25_RS01030	COG2906	2 iron, 2 sulfur cluster binding
GPY25_RS01035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY25_RS01040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY25_RS01045	COG0049	tRNA binding
GPY25_RS01055	COG2168	tRNA wobble position uridine thiolation
GPY25_RS01060	COG2923	Belongs to the DsrF TusC family
GPY25_RS01065	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY25_RS01070	COG2964	Protein conserved in bacteria
GPY25_RS01075	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY25_RS01085	COG2900	Belongs to the SlyX family
GPY25_RS01090	COG1446	asparaginase
GPY25_RS01100	COG1047	Peptidyl-prolyl cis-trans
GPY25_RS01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY25_RS01125	COG0488	(ABC) transporter
GPY25_RS01135	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY25_RS01140	COG3089	Belongs to the UPF0270 family
GPY25_RS01145	COG3954	Phosphoribulokinase
GPY25_RS01150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY25_RS01160	COG1012	belongs to the aldehyde dehydrogenase family
GPY25_RS01170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY25_RS01175	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY25_RS01205	COG0180	Tryptophanyl-tRNA synthetase
GPY25_RS01210	COG0546	phosphoglycolate phosphatase activity
GPY25_RS01215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY25_RS01220	COG0557	exoribonuclease II activity
GPY25_RS01225	COG1959	2 iron, 2 sulfur cluster binding
GPY25_RS01230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY25_RS01230	COG1017	nitric oxide dioxygenase activity
GPY25_RS01235	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY25_RS01245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY25_RS01250	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY25_RS01255	COG0330	HflC and HflK could
GPY25_RS01260	COG0330	HflC and HflK could
GPY25_RS01265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY25_RS01275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY25_RS01280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY25_RS01285	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY25_RS01290	COG0802	atpase or kinase
GPY25_RS01295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY25_RS01365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY25_RS01370	COG1162	GTPase activity
GPY25_RS01375	COG0688	phosphatidylethanolamine metabolic process
GPY25_RS01380	COG0471	metal ion transport
GPY25_RS01395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY25_RS01400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY25_RS01405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY25_RS01410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY25_RS01415	COG1045	serine acetyltransferase
GPY25_RS01420	COG4942	peptidase
GPY25_RS01440	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY25_RS01450	COG1053	succinate dehydrogenase
GPY25_RS01455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY25_RS01460	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY25_RS01465	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY25_RS01475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY25_RS01480	COG1509	lysine 2,3-aminomutase activity
GPY25_RS01490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY25_RS01505	COG0459	protein refolding
GPY25_RS01510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY25_RS01515	COG0534	Mate efflux family protein
GPY25_RS01520	COG0205	6-phosphofructokinase activity
GPY25_RS01530	COG3678	ATP-independent chaperone mediated protein folding
GPY25_RS01535	COG0745	RESPONSE REGULATOR receiver
GPY25_RS01540	COG2205	protein histidine kinase activity
GPY25_RS01550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY25_RS01555	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY25_RS01560	COG1027	Aspartate ammonia-lyase
GPY25_RS01565	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY25_RS01570	COG4232	protein-disulfide reductase activity
GPY25_RS01580	COG3263	regulation of cellular component size
GPY25_RS01590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY25_RS01615	COG2205	protein histidine kinase activity
GPY25_RS01615	COG0784	Response regulator, receiver
GPY25_RS01620	COG2814	Major facilitator Superfamily
GPY25_RS01635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY25_RS01640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY25_RS01645	COG0511	ligase activity, forming carbon-carbon bonds
GPY25_RS01650	COG0439	Biotin carboxylase
GPY25_RS01660	COG2264	protein methyltransferase activity
GPY25_RS01665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY25_RS01670	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY25_RS01675	COG2814	Major facilitator Superfamily
GPY25_RS01680	COG0488	(ABC) transporter
GPY25_RS01685	COG3706	GGDEF domain
GPY25_RS01750	COG1982	Orn Lys Arg decarboxylase major
GPY25_RS01755	COG0531	amino acid
GPY25_RS01765	COG3710	Transcriptional regulator
GPY25_RS01770	COG0789	Transcriptional regulator
GPY25_RS01780	COG0138	bifunctional purine biosynthesis protein purh
GPY25_RS01790	COG0151	Belongs to the GarS family
GPY25_RS01805	COG1253	flavin adenine dinucleotide binding
GPY25_RS01810	COG3068	Protein conserved in bacteria
GPY25_RS01815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY25_RS01820	COG1573	uracil-dna glycosylase
GPY25_RS01825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY25_RS01840	COG2816	NAD+ diphosphatase activity
GPY25_RS01845	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY25_RS01850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY25_RS01855	COG0085	RNA polymerase activity
GPY25_RS01860	COG0222	ribosome binding
GPY25_RS01865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY25_RS01870	COG0081	regulation of translation
GPY25_RS01875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY25_RS01880	COG0250	Participates in transcription elongation, termination and antitermination
GPY25_RS01885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY25_RS01895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY25_RS01930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY25_RS01940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY25_RS01970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY25_RS01980	COG4206	TonB-dependent receptor
GPY25_RS01985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY25_RS02000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY25_RS02005	COG0534	Mate efflux family protein
GPY25_RS02010	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY25_RS02015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY25_RS02025	COG2937	Belongs to the GPAT DAPAT family
GPY25_RS02030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY25_RS02035	COG3161	chorismate lyase activity
GPY25_RS02040	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY25_RS02045	COG0705	Rhomboid family
GPY25_RS02050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY25_RS02060	COG2177	Part of the ABC transporter FtsEX involved in
GPY25_RS02065	COG2884	Cell division ATP-binding protein ftsE
GPY25_RS02070	COG0552	protein localization to endoplasmic reticulum
GPY25_RS02075	COG0742	ribosomal rna small subunit methyltransferase
GPY25_RS02085	COG2095	MarC family integral membrane protein
GPY25_RS02140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY25_RS02145	COG0640	Transcriptional regulator
GPY25_RS02150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY25_RS02155	COG1280	lysine exporter protein (LysE YggA)
GPY25_RS02160	COG2267	carboxylic ester hydrolase activity
GPY25_RS02165	COG0561	phosphatase activity
GPY25_RS02185	COG3287	FIST C domain
GPY25_RS02185	COG2200	EAL domain
GPY25_RS02185	COG2199	diguanylate cyclase activity
GPY25_RS02190	COG1011	Hydrolase
GPY25_RS02195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY25_RS02205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY25_RS02210	COG0019	diaminopimelate decarboxylase activity
GPY25_RS02220	COG1965	Belongs to the frataxin family
GPY25_RS02225	COG3072	Adenylate cyclase
GPY25_RS02230	COG0181	hydroxymethylbilane synthase activity
GPY25_RS02235	COG1587	Uroporphyrinogen-III synthase
GPY25_RS02240	COG2959	enzyme of heme biosynthesis
GPY25_RS02245	COG3071	HemY protein
GPY25_RS02295	COG0633	Ferredoxin
GPY25_RS02300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY25_RS02315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY25_RS02320	COG3118	belongs to the thioredoxin family
GPY25_RS02325	COG0513	Belongs to the DEAD box helicase family
GPY25_RS02330	COG0248	Ppx GppA phosphatase
GPY25_RS02335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY25_RS02350	COG0514	ATP-dependent DNA helicase (RecQ)
GPY25_RS02355	COG2962	Rard protein
GPY25_RS02365	COG1280	lysine exporter protein (LysE YggA)
GPY25_RS02370	COG0405	Gamma-glutamyltransferase
GPY25_RS02380	COG0210	DNA helicase
GPY25_RS02390	COG3220	belongs to the UPF0276 family
GPY25_RS02420	COG0006	proline dipeptidase activity
GPY25_RS02420	COG0006	proline dipeptidase activity
GPY25_RS02430	COG2022	thiamine diphosphate biosynthetic process
GPY25_RS02435	COG2104	thiamine diphosphate biosynthetic process
GPY25_RS02440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY25_RS02445	COG0352	thiamine-phosphate diphosphorylase activity
GPY25_RS02450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY25_RS02455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY25_RS02460	COG3335	DDE superfamily endonuclease
GPY25_RS02540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY25_RS02545	COG1739	Uncharacterized protein family UPF0029
GPY25_RS02550	COG1024	Enoyl-CoA hydratase
GPY25_RS02550	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY25_RS02555	COG0183	Belongs to the thiolase family
GPY25_RS02560	COG0604	alcohol dehydrogenase
GPY25_RS02575	COG0425	Belongs to the sulfur carrier protein TusA family
GPY25_RS02585	COG2119	membrane
GPY25_RS02590	COG0752	glycyl-tRNA synthetase alpha subunit
GPY25_RS02595	COG0751	glycine-tRNA ligase activity
GPY25_RS02600	COG0366	Alpha amylase catalytic
GPY25_RS02605	COG3977	Valine--pyruvate aminotransferase
GPY25_RS02610	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY25_RS02630	COG0187	DNA topoisomerase II activity
GPY25_RS02635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY25_RS02640	COG0592	DNA-directed DNA polymerase activity
GPY25_RS02645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY25_RS02670	COG1126	abc transporter atp-binding protein
GPY25_RS02680	COG0594	ribonuclease P activity
GPY25_RS02685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY25_RS02690	COG0706	membrane insertase activity
GPY25_RS02695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY25_RS02735	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY25_RS02745	COG3645	SOS response
GPY25_RS02750	COG3645	SOS response
GPY25_RS02800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY25_RS02805	COG0445	tRNA wobble uridine modification
GPY25_RS02810	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY25_RS02815	COG1192	Involved in chromosome partitioning
GPY25_RS02820	COG1475	DNA binding
GPY25_RS02825	COG3312	ion transport
GPY25_RS02830	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY25_RS02845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY25_RS02850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY25_RS02855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY25_RS02860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY25_RS02865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY25_RS02870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY25_RS02875	COG0765	amino acid transport
GPY25_RS02880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY25_RS02885	COG2814	Major facilitator Superfamily
GPY25_RS02890	COG0583	DNA-binding transcription factor activity
GPY25_RS02900	COG0129	dihydroxy-acid dehydratase activity
GPY25_RS02905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY25_RS02910	COG3978	acetolactate synthase activity
GPY25_RS02920	COG0606	chelatase, subunit chli
GPY25_RS02930	COG0204	Acyl-transferase
GPY25_RS02935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY25_RS02940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY25_RS02950	COG3084	Protein conserved in bacteria
GPY25_RS02960	COG4326	sporulation control protein
GPY25_RS02965	COG1272	protein, Hemolysin III
GPY25_RS02975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY25_RS02980	COG0569	domain protein
GPY25_RS02985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY25_RS02985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY25_RS02990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY25_RS02995	COG0242	peptide deformylase activity
GPY25_RS03005	COG0758	DNA mediated transformation
GPY25_RS03010	COG2922	Belongs to the Smg family
GPY25_RS03015	COG0551	DNA topoisomerase type I activity
GPY25_RS03020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY25_RS03025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY25_RS03030	COG0009	L-threonylcarbamoyladenylate synthase
GPY25_RS03035	COG0408	coproporphyrinogen oxidase activity
GPY25_RS03040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY25_RS03050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY25_RS03085	COG0583	DNA-binding transcription factor activity
GPY25_RS03090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY25_RS03095	COG2960	long-chain fatty acid transporting porin activity
GPY25_RS03105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY25_RS03110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS03175	COG4172	Belongs to the ABC transporter superfamily
GPY25_RS03180	COG0747	negative chemotaxis
GPY25_RS03190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY25_RS03230	COG1609	Transcriptional regulator
GPY25_RS03235	COG0583	DNA-binding transcription factor activity
GPY25_RS03245	COG2076	Multidrug Resistance protein
GPY25_RS03250	COG0129	dihydroxy-acid dehydratase activity
GPY25_RS03255	COG3265	gluconokinase activity
GPY25_RS03260	COG2610	gluconate transmembrane transporter activity
GPY25_RS03265	COG0800	Aldolase
GPY25_RS03270	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY25_RS03275	COG0583	DNA-binding transcription factor activity
GPY25_RS03280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY25_RS03285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY25_RS03290	COG0339	signal peptide processing
GPY25_RS03295	COG1522	sequence-specific DNA binding
GPY25_RS03300	COG5002	protein histidine kinase activity
GPY25_RS03300	COG5001	Diguanylate cyclase
GPY25_RS03305	COG0742	ribosomal rna small subunit methyltransferase
GPY25_RS03315	COG0697	spore germination
GPY25_RS03320	COG0589	response to stress
GPY25_RS03325	COG1528	Iron-storage protein
GPY25_RS03335	COG2081	HI0933 family
GPY25_RS03345	COG2823	Periplasmic or secreted lipoprotein
GPY25_RS03395	COG0628	permease
GPY25_RS03410	COG1322	Protein conserved in bacteria
GPY25_RS03415	COG2226	methyltransferase
GPY25_RS03420	COG3165	ubiquinone biosynthetic process from chorismate
GPY25_RS03425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY25_RS03430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY25_RS03440	COG0805	protein transport
GPY25_RS03450	COG0084	hydrolase, TatD family'
GPY25_RS03475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY25_RS03475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY25_RS03485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY25_RS03515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY25_RS03520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY25_RS03530	COG2204	response regulator
GPY25_RS03535	COG3852	Histidine kinase
GPY25_RS03545	COG0174	glutamine synthetase
GPY25_RS03565	COG1295	ribonuclease BN
GPY25_RS03570	COG1490	D-aminoacyl-tRNA deacylase activity
GPY25_RS03575	COG0456	acetyltransferase
GPY25_RS03585	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY25_RS03590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY25_RS03595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY25_RS03600	COG3031	protein transport across the cell outer membrane
GPY25_RS03610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY25_RS03615	COG1459	type II secretion system
GPY25_RS03620	COG2165	general secretion pathway protein
GPY25_RS03625	COG2165	general secretion pathway protein
GPY25_RS03630	COG2165	general secretion pathway protein
GPY25_RS03635	COG4795	General secretion pathway protein
GPY25_RS03640	COG3156	type II secretion system protein K
GPY25_RS03645	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY25_RS03650	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY25_RS03660	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY25_RS03665	COG0494	nUDIX hydrolase
GPY25_RS03670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY25_RS03670	COG0316	Belongs to the HesB IscA family
GPY25_RS03675	COG1040	competence protein
GPY25_RS03680	COG0596	Alpha beta hydrolase
GPY25_RS03690	COG2183	response to ionizing radiation
GPY25_RS03700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY25_RS03710	COG0745	RESPONSE REGULATOR receiver
GPY25_RS03715	COG2205	protein histidine kinase activity
GPY25_RS03720	COG2233	PERMEase
GPY25_RS03725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY25_RS03730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY25_RS03735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY25_RS03740	COG1758	RNA polymerase activity
GPY25_RS03745	COG0194	GDP metabolic process
GPY25_RS03760	COG0848	biopolymer transport protein
GPY25_RS03765	COG0811	peptide transport
GPY25_RS03790	COG4174	ABC transporter (Permease)
GPY25_RS03795	COG4239	(ABC) transporter, permease
GPY25_RS03800	COG0747	negative chemotaxis
GPY25_RS03805	COG0444	Belongs to the ABC transporter superfamily
GPY25_RS03810	COG4608	Belongs to the ABC transporter superfamily
GPY25_RS03855	COG0328	RNA-DNA hybrid ribonuclease activity
GPY25_RS03915	COG2003	Belongs to the UPF0758 family
GPY25_RS03935	COG1561	YicC-like family, N-terminal region
GPY25_RS03940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY25_RS03945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY25_RS03950	COG1560	Kdo2-lipid A biosynthetic process
GPY25_RS03955	COG1309	transcriptional regulator
GPY25_RS03960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY25_RS03975	COG2003	Belongs to the UPF0758 family
GPY25_RS03980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY25_RS03990	COG2194	sulfuric ester hydrolase activity
GPY25_RS04000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY25_RS04005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY25_RS04020	COG0463	Glycosyl transferase, family 2
GPY25_RS04025	COG0859	PFAM glycosyl transferase family 9
GPY25_RS04030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY25_RS04035	COG3642	lipopolysaccharide core region biosynthetic process
GPY25_RS04045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPY25_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS04105	COG1519	Transferase
GPY25_RS04115	COG0859	PFAM glycosyl transferase family 9
GPY25_RS04125	COG1560	Kdo2-lipid A biosynthetic process
GPY25_RS04135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY25_RS04225	COG0438	transferase activity, transferring glycosyl groups
GPY25_RS04230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPY25_RS04235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY25_RS04255	COG1482	cell wall glycoprotein biosynthetic process
GPY25_RS04270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY25_RS04290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY25_RS04295	COG0149	triose-phosphate isomerase activity
GPY25_RS04320	COG1494	fructose-1,6-bisphosphatase
GPY25_RS04330	COG3074	FtsZ-dependent cytokinesis
GPY25_RS04335	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY25_RS04340	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY25_RS04345	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY25_RS04350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY25_RS04360	COG1609	Transcriptional regulator
GPY25_RS04365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY25_RS04375	COG0254	rRNA binding
GPY25_RS04385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY25_RS04390	COG0088	Forms part of the polypeptide exit tunnel
GPY25_RS04400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY25_RS04405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY25_RS04410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY25_RS04415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY25_RS04425	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY25_RS04430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY25_RS04435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY25_RS04440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY25_RS04445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY25_RS04450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY25_RS04455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY25_RS04460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY25_RS04475	COG1841	ribosomal large subunit assembly
GPY25_RS04480	COG0200	Binds to the 23S rRNA
GPY25_RS04485	COG0201	protein transport
GPY25_RS04495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY25_RS04500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY25_RS04510	COG0202	RNA polymerase activity
GPY25_RS04515	COG0203	ribosomal protein L17
GPY25_RS04525	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY25_RS04535	COG2153	protein acetylation
GPY25_RS04540	COG0513	Belongs to the DEAD box helicase family
GPY25_RS04550	COG0737	Belongs to the 5'-nucleotidase family
GPY25_RS04555	COG1648	precorrin-2 dehydrogenase activity
GPY25_RS04555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY25_RS04560	COG0175	sulfate reduction
GPY25_RS04565	COG2895	sulfate adenylyltransferase (ATP) activity
GPY25_RS04575	COG0471	metal ion transport
GPY25_RS04575	COG3273	potassium ion transport
GPY25_RS04580	COG0529	Catalyzes the synthesis of activated sulfate
GPY25_RS04600	COG4181	ATPase activity
GPY25_RS04615	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY25_RS04625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY25_RS04630	COG0729	surface antigen
GPY25_RS04635	COG2911	Protein conserved in bacteria
GPY25_RS04640	COG2105	PFAM AIG2 family protein
GPY25_RS04650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY25_RS04655	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY25_RS04665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY25_RS04670	COG0163	prenyltransferase activity
GPY25_RS04675	COG4143	(ABC) transporter
GPY25_RS04680	COG1178	ABC-type Fe3 transport system permease component
GPY25_RS04685	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY25_RS04720	COG0039	L-malate dehydrogenase activity
GPY25_RS04730	COG0142	geranyltranstransferase activity
GPY25_RS04735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY25_RS04745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY25_RS04750	COG2966	Psort location CytoplasmicMembrane, score
GPY25_RS04765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY25_RS04770	COG2967	ApaG domain
GPY25_RS04775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY25_RS04780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY25_RS04785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY25_RS04790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY25_RS04795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY25_RS04805	COG0066	3-isopropylmalate dehydratase activity
GPY25_RS04810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY25_RS04815	COG0473	3-isopropylmalate dehydrogenase activity
GPY25_RS04820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY25_RS04845	COG0583	DNA-binding transcription factor activity
GPY25_RS04850	COG1022	Amp-dependent synthetase and ligase
GPY25_RS04855	COG0028	Belongs to the TPP enzyme family
GPY25_RS04860	COG0440	acetolactate synthase activity
GPY25_RS04865	COG3706	GGDEF domain
GPY25_RS04875	COG0469	pyruvate kinase activity
GPY25_RS04885	COG1349	DNA-binding transcription factor activity
GPY25_RS04890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY25_RS04905	COG5002	protein histidine kinase activity
GPY25_RS04915	COG2376	Dihydroxyacetone kinase
GPY25_RS04920	COG1461	Dihydroxyacetone kinase
GPY25_RS04935	COG3722	fumarate hydratase activity
GPY25_RS04940	COG0246	Mannitol dehydrogenase
GPY25_RS04945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY25_RS04945	COG2213	PTS system mannitol-specific
GPY25_RS04980	COG2207	Transcriptional regulator
GPY25_RS04990	COG1464	Belongs to the NlpA lipoprotein family
GPY25_RS05000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY25_RS05005	COG0358	DNA primase activity
GPY25_RS05010	COG1610	YqeY-like protein
GPY25_RS05015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY25_RS05020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY25_RS05025	COG0596	Alpha beta hydrolase
GPY25_RS05030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY25_RS05035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY25_RS05040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY25_RS05045	COG1968	undecaprenyl-diphosphatase activity
GPY25_RS05050	COG0617	tRNA 3'-terminal CCA addition
GPY25_RS05055	COG3409	Peptidoglycan-binding domain 1 protein
GPY25_RS05055	COG3267	Type II secretory pathway component ExeA
GPY25_RS05065	COG4991	sh3 domain protein
GPY25_RS05070	COG0306	phosphate transporter
GPY25_RS05075	COG1392	Phosphate transport regulator
GPY25_RS05080	COG3025	triphosphatase activity
GPY25_RS05095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY25_RS05100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY25_RS05100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY25_RS05105	COG1538	Outer membrane efflux protein
GPY25_RS05110	COG0494	nUDIX hydrolase
GPY25_RS05115	COG3151	Protein conserved in bacteria
GPY25_RS05125	COG3150	esterase
GPY25_RS05130	COG0187	DNA topoisomerase II activity
GPY25_RS05135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY25_RS05140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY25_RS05150	COG3105	Protein conserved in bacteria
GPY25_RS05160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY25_RS05170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY25_RS05175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY25_RS05180	COG0723	plastoquinol--plastocyanin reductase activity
GPY25_RS05185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY25_RS05190	COG2857	Cytochrome c1
GPY25_RS05195	COG0625	glutathione transferase activity
GPY25_RS05200	COG2969	positive regulation of protein catabolic process
GPY25_RS05205	COG2823	Periplasmic or secreted lipoprotein
GPY25_RS05210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY25_RS05215	COG0792	nuclease activity
GPY25_RS05225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY25_RS05240	COG0275	rRNA processing
GPY25_RS05245	COG3116	cell division
GPY25_RS05250	COG0768	penicillin binding
GPY25_RS05255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY25_RS05260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY25_RS05265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY25_RS05270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY25_RS05275	COG0772	Belongs to the SEDS family
GPY25_RS05280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY25_RS05285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY25_RS05290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY25_RS05295	COG0849	cell division
GPY25_RS05300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY25_RS05305	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY25_RS05315	COG0653	protein targeting
GPY25_RS05320	COG0494	nUDIX hydrolase
GPY25_RS05325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY25_RS05330	COG0505	Belongs to the CarA family
GPY25_RS05335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY25_RS05345	COG0730	response to heat
GPY25_RS05350	COG0583	DNA-binding transcription factor activity
GPY25_RS05355	COG2860	membrane
GPY25_RS05360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY25_RS05370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY25_RS05380	COG0493	'glutamate synthase
GPY25_RS05385	COG0070	glutamate synthase
GPY25_RS05385	COG0069	glutamate synthase activity
GPY25_RS05385	COG0067	glutamate synthase
GPY25_RS05395	COG0067	glutamate synthase
GPY25_RS05395	COG0069	glutamate synthase activity
GPY25_RS05395	COG0070	glutamate synthase
GPY25_RS05400	COG1242	4 iron, 4 sulfur cluster binding
GPY25_RS05405	COG5001	Diguanylate cyclase
GPY25_RS05405	COG4251	negative regulation of phosphorylation
GPY25_RS05405	COG3706	GGDEF domain
GPY25_RS05405	COG2203	Gaf domain
GPY25_RS05410	COG5002	protein histidine kinase activity
GPY25_RS05410	COG0784	Response regulator, receiver
GPY25_RS05410	COG2198	Histidine kinase
GPY25_RS05420	COG0745	RESPONSE REGULATOR receiver
GPY25_RS05435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY25_RS05450	COG0083	homoserine kinase activity
GPY25_RS05455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY25_RS05460	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY25_RS05465	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY25_RS05475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY25_RS05490	COG1115	amino acid carrier protein
GPY25_RS05495	COG3022	response to hydroperoxide
GPY25_RS05500	COG0513	Belongs to the DEAD box helicase family
GPY25_RS05505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY25_RS05515	COG0716	FMN binding
GPY25_RS05525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY25_RS05530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY25_RS05540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY25_RS05555	COG0667	Aldo Keto reductase
GPY25_RS05565	COG3066	DNA modification
GPY25_RS05575	COG0494	nUDIX hydrolase
GPY25_RS05585	COG0730	response to heat
GPY25_RS05590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY25_RS05595	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY25_RS05605	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY25_RS05610	COG0583	DNA-binding transcription factor activity
GPY25_RS05620	COG0640	Transcriptional regulator
GPY25_RS05630	COG0268	Binds directly to 16S ribosomal RNA
GPY25_RS05635	COG0728	peptidoglycan biosynthetic process
GPY25_RS05640	COG0196	riboflavin kinase activity
GPY25_RS05645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY25_RS05650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY25_RS05655	COG1047	Peptidyl-prolyl cis-trans
GPY25_RS05660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY25_RS05665	COG3279	Response regulator of the LytR AlgR family
GPY25_RS05670	COG3275	phosphorelay sensor kinase activity
GPY25_RS05675	COG1966	Carbon starvation protein
GPY25_RS05690	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY25_RS05695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY25_RS05700	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY25_RS05705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY25_RS05710	COG0287	Prephenate dehydrogenase
GPY25_RS05710	COG1605	Chorismate mutase
GPY25_RS05715	COG0739	heme binding
GPY25_RS05730	COG0488	(ABC) transporter
GPY25_RS05740	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY25_RS05745	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY25_RS05750	COG0077	Prephenate dehydratase
GPY25_RS05750	COG1605	Chorismate mutase
GPY25_RS05755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY25_RS05760	COG0741	lytic transglycosylase activity
GPY25_RS05765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY25_RS05770	COG0564	pseudouridine synthase activity
GPY25_RS05780	COG0542	response to heat
GPY25_RS05840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY25_RS05850	COG2974	May be involved in recombination
GPY25_RS05855	COG0745	RESPONSE REGULATOR receiver
GPY25_RS05860	COG5002	protein histidine kinase activity
GPY25_RS05870	COG0248	Ppx GppA phosphatase
GPY25_RS05875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY25_RS05885	COG0581	inorganic phosphate transmembrane transporter activity
GPY25_RS05890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY25_RS05895	COG0704	Plays a role in the regulation of phosphate uptake
GPY25_RS05905	COG3142	Participates in the control of copper homeostasis
GPY25_RS05910	COG0450	alkyl hydroperoxide reductase
GPY25_RS05915	COG0583	DNA-binding transcription factor activity
GPY25_RS05925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY25_RS05935	COG0517	IMP dehydrogenase activity
GPY25_RS05945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY25_RS05950	COG0343	queuine tRNA-ribosyltransferase activity
GPY25_RS05955	COG1862	Preprotein translocase
GPY25_RS05960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY25_RS05965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY25_RS05975	COG0483	inositol monophosphate 1-phosphatase activity
GPY25_RS05985	COG1959	2 iron, 2 sulfur cluster binding
GPY25_RS05990	COG1104	cysteine desulfurase activity
GPY25_RS05995	COG0822	iron-sulfur transferase activity
GPY25_RS06005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY25_RS06010	COG0443	Heat shock 70 kDa protein
GPY25_RS06015	COG0633	Ferredoxin
GPY25_RS06020	COG2975	iron-sulfur cluster assembly
GPY25_RS06025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY25_RS06030	COG0105	UTP biosynthetic process
GPY25_RS06035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY25_RS06050	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY25_RS06055	COG0124	histidyl-tRNA synthetase
GPY25_RS06060	COG2976	Protein conserved in bacteria
GPY25_RS06065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY25_RS06070	COG1160	GTP binding
GPY25_RS06085	COG1570	exodeoxyribonuclease VII activity
GPY25_RS06090	COG0516	GMP reductase activity
GPY25_RS06090	COG0517	IMP dehydrogenase activity
GPY25_RS06095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY25_RS06095	COG0519	Catalyzes the synthesis of GMP from XMP
GPY25_RS06100	COG1757	Na H antiporter
GPY25_RS06110	COG1584	GPR1 FUN34 yaaH family protein
GPY25_RS06120	COG1115	amino acid carrier protein
GPY25_RS06155	COG2873	o-acetylhomoserine
GPY25_RS06160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY25_RS06180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY25_RS06180	COG3153	acetyltransferase
GPY25_RS06185	COG0583	DNA-binding transcription factor activity
GPY25_RS06205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY25_RS06210	COG2867	negative regulation of translational initiation
GPY25_RS06215	COG2914	Belongs to the UPF0125 (RnfH) family
GPY25_RS06220	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY25_RS06225	COG0497	DNA recombination
GPY25_RS06235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY25_RS06240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY25_RS06245	COG1301	dicarboxylic acid transport
GPY25_RS06250	COG0443	Heat shock 70 kDa protein
GPY25_RS06255	COG0484	heat shock protein binding
GPY25_RS06270	COG4969	Belongs to the N-Me-Phe pilin family
GPY25_RS06295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY25_RS06300	COG0590	tRNA wobble adenosine to inosine editing
GPY25_RS06310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY25_RS06320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY25_RS06320	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY25_RS06345	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY25_RS06350	COG2252	PERMEase
GPY25_RS06355	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY25_RS06370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY25_RS06375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY25_RS06380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY25_RS06385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY25_RS06385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY25_RS06405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY25_RS06410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY25_RS06415	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY25_RS06420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY25_RS06425	COG0142	geranyltranstransferase activity
GPY25_RS06430	COG1722	exodeoxyribonuclease VII activity
GPY25_RS06435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY25_RS06440	COG2885	chlorophyll binding
GPY25_RS06445	COG0301	tRNA thio-modification
GPY25_RS06445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY25_RS06450	COG0583	DNA-binding transcription factor activity
GPY25_RS06460	COG2363	Small membrane protein
GPY25_RS06465	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GPY25_RS06475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY25_RS06480	COG1611	Belongs to the LOG family
GPY25_RS06485	COG3706	GGDEF domain
GPY25_RS06485	COG0745	RESPONSE REGULATOR receiver
GPY25_RS06495	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY25_RS06495	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY25_RS06505	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY25_RS06510	COG1464	Belongs to the NlpA lipoprotein family
GPY25_RS06515	COG2011	ABC-type metal ion transport system permease component
GPY25_RS06520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY25_RS06530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY25_RS06540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY25_RS06540	COG1263	PTS System
GPY25_RS06545	COG0366	Alpha amylase catalytic
GPY25_RS06560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY25_RS06565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY25_RS06570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY25_RS06575	COG0321	lipoyl(octanoyl) transferase activity
GPY25_RS06580	COG2921	Belongs to the UPF0250 family
GPY25_RS06585	COG1686	Belongs to the peptidase S11 family
GPY25_RS06590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY25_RS06595	COG0772	Belongs to the SEDS family
GPY25_RS06600	COG0768	penicillin binding
GPY25_RS06605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY25_RS06610	COG0799	negative regulation of ribosome biogenesis
GPY25_RS06615	COG1466	dna polymerase III delta subunit
GPY25_RS06620	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY25_RS06625	COG0495	leucyl-tRNA aminoacylation
GPY25_RS06630	COG2888	peptidyl-tyrosine sulfation
GPY25_RS06635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY25_RS06640	COG4535	Mg2 and Co2 transporter CorC
GPY25_RS06645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY25_RS06650	COG1702	phosphate starvation-inducible protein PhoH
GPY25_RS06655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY25_RS06665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY25_RS06780	COG0012	GTP binding
GPY25_RS06785	COG0193	aminoacyl-tRNA hydrolase activity
GPY25_RS06790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY25_RS06805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY25_RS06810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY25_RS06815	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY25_RS06820	COG3094	Invasion gene expression up-regulator, SirB
GPY25_RS06825	COG2912	Transglutaminase-like superfamily
GPY25_RS06830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY25_RS06835	COG0737	Belongs to the 5'-nucleotidase family
GPY25_RS06845	COG1187	pseudouridine synthase activity
GPY25_RS06850	COG2840	Smr protein MutS2
GPY25_RS06890	COG2217	Heavy metal translocating P-type atpase
GPY25_RS06890	COG2608	mercury ion transmembrane transporter activity
GPY25_RS06905	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY25_RS06910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY25_RS06970	COG0784	Response regulator, receiver
GPY25_RS06970	COG0835	chemotaxis
GPY25_RS06975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY25_RS06980	COG1815	bacterial-type flagellum-dependent cell motility
GPY25_RS06985	COG1558	bacterial-type flagellum-dependent cell motility
GPY25_RS06990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY25_RS06995	COG1749	Flagellar hook protein flgE
GPY25_RS07005	COG4787	bacterial-type flagellum-dependent cell motility
GPY25_RS07010	COG4786	Flagellar basal body rod
GPY25_RS07015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY25_RS07020	COG1706	bacterial-type flagellum-dependent cell motility
GPY25_RS07025	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY25_RS07025	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY25_RS07035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS07045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS07055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS07060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS07070	COG2190	(PTS) system
GPY25_RS07075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY25_RS07080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY25_RS07090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY25_RS07095	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY25_RS07100	COG3115	cell septum assembly
GPY25_RS07105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY25_RS07130	COG0330	HflC and HflK could
GPY25_RS07135	COG3118	belongs to the thioredoxin family
GPY25_RS07145	COG0300	oxidoreductase activity
GPY25_RS07150	COG1090	epimerase
GPY25_RS07180	COG0622	Phosphoesterase
GPY25_RS07200	COG3710	Transcriptional regulator
GPY25_RS07205	COG0326	Molecular chaperone. Has ATPase activity
GPY25_RS07210	COG0563	adenylate kinase activity
GPY25_RS07215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY25_RS07220	COG3104	oligopeptide transport
GPY25_RS07225	COG0250	Participates in transcription elongation, termination and antitermination
GPY25_RS07230	COG0367	asparagine synthase
GPY25_RS07235	COG4651	solute:proton antiporter activity
GPY25_RS07235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY25_RS07240	COG1846	Transcriptional regulator
GPY25_RS07240	COG1940	carbohydrate kinase activity
GPY25_RS07245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY25_RS07255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY25_RS07255	COG1263	PTS System
GPY25_RS07255	COG2190	(PTS) system
GPY25_RS07260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY25_RS07265	COG0735	belongs to the Fur family
GPY25_RS07275	COG0716	FMN binding
GPY25_RS07285	COG0596	Alpha beta hydrolase
GPY25_RS07290	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY25_RS07295	COG0033	Phosphoglucomutase
GPY25_RS07305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY25_RS07315	COG2009	succinate dehydrogenase
GPY25_RS07320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY25_RS07325	COG1053	succinate dehydrogenase
GPY25_RS07330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY25_RS07335	COG0567	Dehydrogenase, E1 component
GPY25_RS07340	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY25_RS07345	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY25_RS07355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY25_RS07360	COG1121	(ABC) transporter
GPY25_RS07370	COG4977	sequence-specific DNA binding
GPY25_RS07385	COG1918	ferrous iron import across plasma membrane
GPY25_RS07405	COG0018	arginyl-trna synthetase
GPY25_RS07415	COG3102	Protein conserved in bacteria
GPY25_RS07420	COG0788	formyltetrahydrofolate deformylase activity
GPY25_RS07425	COG1199	ATP-dependent helicase activity
GPY25_RS07430	COG1214	PFAM Peptidase M22, glycoprotease
GPY25_RS07445	COG2267	carboxylic ester hydrolase activity
GPY25_RS07450	COG0318	PFAM AMP-dependent synthetase and ligase
GPY25_RS07455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY25_RS07460	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY25_RS07465	COG2894	cell division
GPY25_RS07470	COG0850	regulation of cytokinetic process
GPY25_RS07475	COG3100	YcgL domain-containing protein
GPY25_RS07480	COG2951	lytic endotransglycosylase activity
GPY25_RS07485	COG0583	DNA-binding transcription factor activity
GPY25_RS07490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY25_RS07495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY25_RS07510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY25_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS07520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY25_RS07525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY25_RS07550	COG2986	histidine ammonia-lyase
GPY25_RS07555	COG1216	Glycosyl transferase, family 2
GPY25_RS07560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY25_RS07575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY25_RS07580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY25_RS07585	COG0204	Acyl-transferase
GPY25_RS07585	COG0318	PFAM AMP-dependent synthetase and ligase
GPY25_RS07615	COG1253	flavin adenine dinucleotide binding
GPY25_RS07620	COG0513	Belongs to the DEAD box helicase family
GPY25_RS07625	COG0569	domain protein
GPY25_RS07630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY25_RS07650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY25_RS07655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY25_RS07660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY25_RS07665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY25_RS07675	COG2204	response regulator
GPY25_RS07685	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY25_RS07695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY25_RS07700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY25_RS07705	COG0776	regulation of translation
GPY25_RS07710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY25_RS07715	COG1555	photosystem II stabilization
GPY25_RS07730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY25_RS07735	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY25_RS07740	COG0436	Aminotransferase
GPY25_RS07745	COG1169	isochorismate synthase
GPY25_RS07750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY25_RS07755	COG0596	Alpha beta hydrolase
GPY25_RS07760	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY25_RS07765	COG1441	menaquinone biosynthetic process
GPY25_RS07785	COG2855	membrane
GPY25_RS07790	COG0477	Major facilitator Superfamily
GPY25_RS07835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS07840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY25_RS07870	COG1522	sequence-specific DNA binding
GPY25_RS07880	COG1946	Acyl-CoA thioesterase
GPY25_RS07885	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY25_RS07900	COG2199	diguanylate cyclase activity
GPY25_RS07910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY25_RS07915	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY25_RS07920	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY25_RS07930	COG0516	GMP reductase activity
GPY25_RS07930	COG0517	IMP dehydrogenase activity
GPY25_RS07960	COG0537	adenosine 5'-monophosphoramidase activity
GPY25_RS07985	COG3150	esterase
GPY25_RS07995	COG1252	NADH dehydrogenase
GPY25_RS08010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY25_RS08020	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY25_RS08025	COG1136	(ABC) transporter
GPY25_RS08030	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY25_RS08040	COG0658	competence protein
GPY25_RS08040	COG2333	competence protein COMEC
GPY25_RS08045	COG1132	(ABC) transporter
GPY25_RS08050	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY25_RS08060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY25_RS08065	COG2719	SpoVR family
GPY25_RS08070	COG2718	Belongs to the UPF0229 family
GPY25_RS08075	COG2766	serine protein kinase
GPY25_RS08085	COG3013	Belongs to the UPF0304 family
GPY25_RS08095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY25_RS08105	COG1882	Formate acetyltransferase
GPY25_RS08135	COG4215	(ABC) transporter
GPY25_RS08150	COG0708	Exodeoxyribonuclease III
GPY25_RS08160	COG3923	Primosomal replication protein n
GPY25_RS08165	COG0730	response to heat
GPY25_RS08170	COG1199	ATP-dependent helicase activity
GPY25_RS08180	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY25_RS08185	COG1187	pseudouridine synthase activity
GPY25_RS08195	COG1278	Cold shock
GPY25_RS08200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY25_RS08205	COG0542	response to heat
GPY25_RS08215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY25_RS08220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY25_RS08225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY25_RS08235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY25_RS08245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY25_RS08250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY25_RS08255	COG0297	glycogen (starch) synthase activity
GPY25_RS08275	COG3070	regulator of competence-specific genes
GPY25_RS08280	COG1609	Transcriptional regulator
GPY25_RS08285	COG3381	protein complex oligomerization
GPY25_RS08290	COG0745	RESPONSE REGULATOR receiver
GPY25_RS08295	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY25_RS08300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY25_RS08305	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY25_RS08310	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY25_RS08315	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY25_RS08335	COG0189	ligase activity
GPY25_RS08335	COG4067	protein conserved in archaea
GPY25_RS08345	COG0500	methyltransferase
GPY25_RS08350	COG4106	trans-aconitate 2-methyltransferase activity
GPY25_RS08355	COG1801	Protein of unknown function DUF72
GPY25_RS08360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY25_RS08365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY25_RS08370	COG0840	transmembrane signaling receptor activity
GPY25_RS08375	COG0632	four-way junction helicase activity
GPY25_RS08380	COG2255	four-way junction helicase activity
GPY25_RS08385	COG1271	oxidase subunit
GPY25_RS08390	COG1294	oxidase, subunit
GPY25_RS08395	COG4890	Cyd operon protein YbgT
GPY25_RS08405	COG0824	Thioesterase
GPY25_RS08410	COG0811	peptide transport
GPY25_RS08425	COG0823	Involved in the tonB-independent uptake of proteins
GPY25_RS08430	COG2885	chlorophyll binding
GPY25_RS08435	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY25_RS08440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY25_RS08450	COG3766	membrane
GPY25_RS08460	COG0754	glutathionylspermidine amidase activity
GPY25_RS08470	COG0784	Response regulator, receiver
GPY25_RS08470	COG5002	protein histidine kinase activity
GPY25_RS08485	COG0840	transmembrane signaling receptor activity
GPY25_RS08500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS08505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY25_RS08535	COG3568	Endonuclease Exonuclease Phosphatase
GPY25_RS08550	COG0583	DNA-binding transcription factor activity
GPY25_RS08560	COG0686	Belongs to the AlaDH PNT family
GPY25_RS08570	COG1674	ftsk spoiiie
GPY25_RS08575	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY25_RS08580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY25_RS08585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY25_RS08595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY25_RS08600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY25_RS08605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY25_RS08610	COG0156	8-amino-7-oxononanoate synthase activity
GPY25_RS08620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY25_RS08630	COG0501	Belongs to the peptidase M48B family
GPY25_RS08640	COG0300	oxidoreductase activity
GPY25_RS08655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY25_RS08680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY25_RS08685	COG2915	High frequency lysogenization protein hflD homolog
GPY25_RS08690	COG0482	sulfurtransferase activity
GPY25_RS08700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY25_RS08710	COG1757	Na H antiporter
GPY25_RS08725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY25_RS08730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY25_RS08735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY25_RS08740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY25_RS08740	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY25_RS08745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY25_RS08750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY25_RS08755	COG0107	imidazoleglycerol-phosphate synthase activity
GPY25_RS08760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY25_RS08760	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY25_RS08765	COG3012	SEC-C Motif Domain Protein
GPY25_RS08775	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY25_RS08780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY25_RS08785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY25_RS08790	COG0215	cysteine-tRNA ligase activity
GPY25_RS08795	COG1435	thymidine kinase activity
GPY25_RS08800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY25_RS08825	COG2116	formate transmembrane transporter activity
GPY25_RS08835	COG0390	transport system, permease component
GPY25_RS08840	COG4459	periplasmic nitrate reductase
GPY25_RS08845	COG3005	denitrification pathway
GPY25_RS08850	COG0243	molybdopterin cofactor binding
GPY25_RS08865	COG1227	inorganic diphosphatase activity
GPY25_RS08875	COG4172	Belongs to the ABC transporter superfamily
GPY25_RS08885	COG4171	peptide transport system, permease
GPY25_RS08890	COG4168	peptide transport system, permease
GPY25_RS08900	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY25_RS08905	COG1842	Phage shock protein A
GPY25_RS08915	COG1983	PspC domain protein
GPY25_RS08920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS08935	COG2818	Glycosylase
GPY25_RS08940	COG5380	lipid catabolic process
GPY25_RS08945	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY25_RS08950	COG0626	cystathionine gamma-synthase activity
GPY25_RS08960	COG0733	neurotransmitter:sodium symporter activity
GPY25_RS08970	COG0564	pseudouridine synthase activity
GPY25_RS08980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY25_RS08985	COG1151	hydroxylamine reductase activity
GPY25_RS08990	COG3604	Transcriptional regulator
GPY25_RS09005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY25_RS09010	COG4136	ATPase activity
GPY25_RS09015	COG4135	transport system, permease component
GPY25_RS09020	COG4134	Bacterial extracellular solute-binding protein
GPY25_RS09025	COG0398	Pfam SNARE associated Golgi protein
GPY25_RS09035	COG0493	'glutamate synthase
GPY25_RS09060	COG3313	Fe-S protein
GPY25_RS09090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY25_RS09095	COG2205	protein histidine kinase activity
GPY25_RS09100	COG0745	RESPONSE REGULATOR receiver
GPY25_RS09110	COG1061	Type III restriction enzyme res subunit
GPY25_RS09115	COG1187	pseudouridine synthase activity
GPY25_RS09120	COG2814	Major facilitator Superfamily
GPY25_RS09150	COG3005	denitrification pathway
GPY25_RS09155	COG0702	epimerase
GPY25_RS09160	COG0534	Mate efflux family protein
GPY25_RS09165	COG4181	ATPase activity
GPY25_RS09180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY25_RS09195	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY25_RS09200	COG3273	potassium ion transport
GPY25_RS09200	COG2985	domain, Protein
GPY25_RS09205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY25_RS09220	COG1737	Transcriptional regulator
GPY25_RS09225	COG0076	glutamate decarboxylase activity
GPY25_RS09235	COG2431	L-lysine efflux transmembrane transporter activity
GPY25_RS09250	COG3070	regulator of competence-specific genes
GPY25_RS09265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY25_RS09265	COG4191	Histidine kinase
GPY25_RS09275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY25_RS09280	COG3048	D-serine ammonia-lyase activity
GPY25_RS09285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY25_RS09290	COG4988	ABC transporter
GPY25_RS09295	COG0492	ferredoxin-NADP+ reductase activity
GPY25_RS09315	COG3706	GGDEF domain
GPY25_RS09315	COG0745	RESPONSE REGULATOR receiver
GPY25_RS09320	COG0471	metal ion transport
GPY25_RS09325	COG2949	membrane
GPY25_RS09330	COG0281	malic enzyme
GPY25_RS09335	COG1643	Atp-dependent helicase
GPY25_RS09340	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY25_RS09355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY25_RS09390	COG0247	lactate metabolic process
GPY25_RS09390	COG0277	FAD linked oxidase domain protein
GPY25_RS09405	COG2986	histidine ammonia-lyase
GPY25_RS09410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY25_RS09415	COG0010	Belongs to the arginase family
GPY25_RS09420	COG1228	amidohydrolase
GPY25_RS09425	COG2188	Transcriptional regulator
GPY25_RS09440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY25_RS09450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY25_RS09460	COG0393	Putative heavy-metal-binding
GPY25_RS09490	COG3706	GGDEF domain
GPY25_RS09495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY25_RS09500	COG0072	phenylalanine-tRNA ligase activity
GPY25_RS09500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY25_RS09515	COG0776	regulation of translation
GPY25_RS09525	COG0500	methyltransferase
GPY25_RS09530	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY25_RS09535	COG0295	cytidine deaminase activity
GPY25_RS09540	COG1346	cytolysis
GPY25_RS09545	COG1380	Effector of murein hydrolase LrgA
GPY25_RS09550	COG2925	Exonuclease
GPY25_RS09560	COG0702	epimerase
GPY25_RS09565	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY25_RS09570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY25_RS09595	COG2988	succinylglutamate desuccinylase activity
GPY25_RS09600	COG4139	cobalamin transport
GPY25_RS09605	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY25_RS09625	COG0583	DNA-binding transcription factor activity
GPY25_RS09645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY25_RS09650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY25_RS09655	COG3475	LICD family
GPY25_RS09660	COG1451	nucleotide metabolic process
GPY25_RS09665	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY25_RS09695	COG3938	Belongs to the proline racemase family
GPY25_RS09715	COG2423	ornithine cyclodeaminase activity
GPY25_RS09720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY25_RS09730	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY25_RS09735	COG1177	transmembrane transport
GPY25_RS09745	COG3291	Pkd domain containing protein
GPY25_RS09765	COG0444	Belongs to the ABC transporter superfamily
GPY25_RS09770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY25_RS09775	COG0601	transmembrane transport
GPY25_RS09785	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY25_RS09795	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY25_RS09805	COG0625	glutathione transferase activity
GPY25_RS09915	COG1278	Cold shock
GPY25_RS09920	COG0557	exoribonuclease II activity
GPY25_RS09965	COG1783	phage Terminase large subunit
GPY25_RS10195	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY25_RS10200	COG0583	DNA-binding transcription factor activity
GPY25_RS10235	COG0471	metal ion transport
GPY25_RS10240	COG4191	Histidine kinase
GPY25_RS10240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY25_RS10250	COG5001	Diguanylate cyclase
GPY25_RS10250	COG3300	MHYT domain
GPY25_RS10260	COG1280	lysine exporter protein (LysE YggA)
GPY25_RS10265	COG1328	CTP reductase activity
GPY25_RS10270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY25_RS10280	COG0861	Integral membrane protein TerC family
GPY25_RS10290	COG0739	heme binding
GPY25_RS10310	COG2885	chlorophyll binding
GPY25_RS10330	COG3501	Rhs element vgr protein
GPY25_RS10355	COG0515	serine threonine protein kinase
GPY25_RS10390	COG1522	sequence-specific DNA binding
GPY25_RS10460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY25_RS10475	COG0814	amino acid
GPY25_RS10500	COG1132	(ABC) transporter
GPY25_RS10505	COG1132	(ABC) transporter
GPY25_RS10535	COG0443	Heat shock 70 kDa protein
GPY25_RS10540	COG0443	Heat shock 70 kDa protein
GPY25_RS10580	COG0243	molybdopterin cofactor binding
GPY25_RS10585	COG0437	4 iron, 4 sulfur cluster binding
GPY25_RS10590	COG3302	dmso reductase anchor subunit
GPY25_RS10605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY25_RS10610	COG1643	Atp-dependent helicase
GPY25_RS10625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY25_RS10635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY25_RS10640	COG1215	transferase activity, transferring glycosyl groups
GPY25_RS10645	COG0438	transferase activity, transferring glycosyl groups
GPY25_RS10680	COG0438	transferase activity, transferring glycosyl groups
GPY25_RS10690	COG2204	response regulator
GPY25_RS10725	COG1793	dna ligase
GPY25_RS10735	COG0534	Mate efflux family protein
GPY25_RS10740	COG0307	riboflavin synthase, alpha
GPY25_RS10755	COG2201	protein-glutamate methylesterase activity
GPY25_RS10760	COG3706	GGDEF domain
GPY25_RS10770	COG0791	NLP P60 protein
GPY25_RS10775	COG0840	transmembrane signaling receptor activity
GPY25_RS10775	COG3290	protein histidine kinase activity
GPY25_RS10815	COG1940	carbohydrate kinase activity
GPY25_RS10825	COG0303	'Molybdopterin
GPY25_RS10830	COG0746	molybdenum cofactor guanylyltransferase activity
GPY25_RS10835	COG3842	ATPase activity
GPY25_RS10855	COG2204	response regulator
GPY25_RS10860	COG4191	Histidine kinase
GPY25_RS10870	COG0488	(ABC) transporter
GPY25_RS10875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY25_RS10900	COG3381	protein complex oligomerization
GPY25_RS10910	COG0243	molybdopterin cofactor binding
GPY25_RS10910	COG3383	formate dehydrogenase (NAD+) activity
GPY25_RS10915	COG0437	4 iron, 4 sulfur cluster binding
GPY25_RS10955	COG0004	ammonium transporteR
GPY25_RS10965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY25_RS10970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY25_RS10975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY25_RS10980	COG1177	transmembrane transport
GPY25_RS10985	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY25_RS10990	COG3842	ATPase activity
GPY25_RS11010	COG0037	tRNA processing
GPY25_RS11020	COG0589	response to stress
GPY25_RS11025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY25_RS11040	COG2217	Heavy metal translocating P-type atpase
GPY25_RS11050	COG2010	Cytochrome c
GPY25_RS11065	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY25_RS11100	COG3120	sequence-specific DNA binding
GPY25_RS11105	COG1067	ATP-dependent peptidase activity
GPY25_RS11110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY25_RS11135	COG0116	Belongs to the methyltransferase superfamily
GPY25_RS11135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY25_RS11150	COG0167	dihydroorotate dehydrogenase activity
GPY25_RS11155	COG2902	Dehydrogenase
GPY25_RS11165	COG0308	aminopeptidase N
GPY25_RS11180	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY25_RS11185	COG1956	GAF domain-containing protein
GPY25_RS11190	COG1132	(ABC) transporter
GPY25_RS11195	COG2995	paraquat-inducible protein a
GPY25_RS11200	COG3008	intermembrane lipid transfer
GPY25_RS11205	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY25_RS11205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY25_RS11225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY25_RS11230	COG1666	GTP binding
GPY25_RS11245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY25_RS11250	COG4597	amino acid ABC transporter
GPY25_RS11255	COG0765	amino acid transport
GPY25_RS11260	COG1126	abc transporter atp-binding protein
GPY25_RS11265	COG0670	Belongs to the BI1 family
GPY25_RS11275	COG2920	part of a sulfur-relay system
GPY25_RS11280	COG1254	Belongs to the acylphosphatase family
GPY25_RS11285	COG0840	transmembrane signaling receptor activity
GPY25_RS11290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY25_RS11330	COG3706	GGDEF domain
GPY25_RS11335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY25_RS11340	COG0602	queuosine metabolic process
GPY25_RS11345	COG0561	phosphatase activity
GPY25_RS11360	COG0456	acetyltransferase
GPY25_RS11370	COG2828	Protein conserved in bacteria
GPY25_RS11380	COG0372	Belongs to the citrate synthase family
GPY25_RS11385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY25_RS11415	COG0730	response to heat
GPY25_RS11435	COG0457	Tetratricopeptide repeat
GPY25_RS11500	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY25_RS11505	COG4790	Type iii secretion
GPY25_RS11510	COG4794	Type iii secretion
GPY25_RS11515	COG4791	protein targeting
GPY25_RS11520	COG4792	protein secretion
GPY25_RS11570	COG3177	Filamentation induced by cAMP protein fic
GPY25_RS11590	COG4669	(LipO)protein
GPY25_RS11660	COG1012	belongs to the aldehyde dehydrogenase family
GPY25_RS11665	COG3284	Transcriptional regulator
GPY25_RS11685	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY25_RS11690	COG0363	glucosamine-6-phosphate deaminase activity
GPY25_RS11695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY25_RS11700	COG4565	transcriptional regulatory protein
GPY25_RS11705	COG3290	protein histidine kinase activity
GPY25_RS11720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS11735	COG1858	cytochrome C peroxidase
GPY25_RS11740	COG0527	aspartate kinase activity
GPY25_RS11745	COG0662	Cupin 2, conserved barrel domain protein
GPY25_RS11750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY25_RS11755	COG0456	acetyltransferase
GPY25_RS11760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY25_RS11780	COG4176	ABC-type proline glycine betaine transport system permease component
GPY25_RS11785	COG2113	Glycine betaine
GPY25_RS11795	COG1022	Amp-dependent synthetase and ligase
GPY25_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS11815	COG0745	RESPONSE REGULATOR receiver
GPY25_RS11820	COG0642	Histidine kinase
GPY25_RS11825	COG1368	sulfuric ester hydrolase activity
GPY25_RS11850	COG1115	amino acid carrier protein
GPY25_RS11860	COG1280	lysine exporter protein (LysE YggA)
GPY25_RS11865	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY25_RS11870	COG1560	Kdo2-lipid A biosynthetic process
GPY25_RS11880	COG0531	amino acid
GPY25_RS11895	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY25_RS11900	COG3063	Type IV pilus biogenesis stability protein PilW
GPY25_RS11930	COG0110	maltose O-acetyltransferase activity
GPY25_RS11950	COG2315	Protein conserved in bacteria
GPY25_RS11955	COG1846	Transcriptional regulator
GPY25_RS11970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY25_RS11980	COG2771	luxR family
GPY25_RS11980	COG2200	EAL domain
GPY25_RS11990	COG1227	inorganic diphosphatase activity
GPY25_RS11995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY25_RS12000	COG1012	belongs to the aldehyde dehydrogenase family
GPY25_RS12005	COG2957	Belongs to the agmatine deiminase family
GPY25_RS12015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY25_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
GPY25_RS12025	COG1396	sequence-specific DNA binding
GPY25_RS12025	COG1917	Cupin 2, conserved barrel domain protein
GPY25_RS12030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY25_RS12040	COG0174	glutamine synthetase
GPY25_RS12045	COG1757	Na H antiporter
GPY25_RS12245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY25_RS12245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY25_RS12415	COG0346	lactoylglutathione lyase activity
GPY25_RS12430	COG0456	acetyltransferase
GPY25_RS12510	COG1192	Involved in chromosome partitioning
GPY25_RS12765	COG1051	belongs to the nudix hydrolase family
GPY25_RS12805	COG2026	Addiction module toxin, RelE StbE family
GPY25_RS12895	COG0346	lactoylglutathione lyase activity
GPY25_RS13000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY25_RS13010	COG3768	UPF0283 membrane protein
GPY25_RS13015	COG3106	COG3106 Predicted ATPase
GPY25_RS13035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY25_RS13040	COG0784	Response regulator, receiver
GPY25_RS13040	COG2205	protein histidine kinase activity
GPY25_RS13050	COG0494	nUDIX hydrolase
GPY25_RS13055	COG0814	amino acid
GPY25_RS13060	COG1760	l-serine dehydratase
GPY25_RS13065	COG2200	EAL domain
GPY25_RS13075	COG0720	synthase
GPY25_RS13085	COG0017	Asparaginyl-tRNA synthetase
GPY25_RS13095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY25_RS13120	COG1448	Aminotransferase
GPY25_RS13140	COG0840	transmembrane signaling receptor activity
GPY25_RS13145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY25_RS13150	COG1846	Transcriptional regulator
GPY25_RS13175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY25_RS13190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY25_RS13195	COG3108	Peptidase M15
GPY25_RS13200	COG2989	Protein conserved in bacteria
GPY25_RS13225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY25_RS13235	COG3088	subunit of a heme lyase
GPY25_RS13235	COG4235	cytochrome complex assembly
GPY25_RS13245	COG1138	Cytochrome C-type biogenesis protein
GPY25_RS13250	COG3301	Polysulphide reductase, NrfD
GPY25_RS13255	COG0437	4 iron, 4 sulfur cluster binding
GPY25_RS13265	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY25_RS13285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY25_RS13290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY25_RS13295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY25_RS13320	COG0019	diaminopimelate decarboxylase activity
GPY25_RS13360	COG0322	excinuclease ABC activity
GPY25_RS13365	COG2197	response regulator
GPY25_RS13370	COG0417	DNA replication proofreading
GPY25_RS13380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY25_RS13385	COG3099	Belongs to the UPF0263 family
GPY25_RS13395	COG1187	pseudouridine synthase activity
GPY25_RS13405	COG0009	L-threonylcarbamoyladenylate synthase
GPY25_RS13410	COG0613	PHP domain protein
GPY25_RS13420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY25_RS13425	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY25_RS13430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY25_RS13435	COG0134	indole-3-glycerol-phosphate synthase activity
GPY25_RS13435	COG0135	phosphoribosylanthranilate isomerase activity
GPY25_RS13440	COG0133	tryptophan synthase activity
GPY25_RS13445	COG0159	tryptophan synthase activity
GPY25_RS13450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY25_RS13455	COG0318	PFAM AMP-dependent synthetase and ligase
GPY25_RS13465	COG1301	dicarboxylic acid transport
GPY25_RS13485	COG2917	probably involved in intracellular septation
GPY25_RS13490	COG1607	acyl-coa hydrolase
GPY25_RS13495	COG2350	Protein conserved in bacteria
GPY25_RS13505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY25_RS13515	COG0583	DNA-binding transcription factor activity
GPY25_RS13530	COG2203	Gaf domain
GPY25_RS13530	COG3706	GGDEF domain
GPY25_RS13530	COG4251	negative regulation of phosphorylation
GPY25_RS13530	COG5001	Diguanylate cyclase
GPY25_RS13535	COG1032	radical SAM domain protein
GPY25_RS13540	COG0840	transmembrane signaling receptor activity
GPY25_RS13550	COG0745	RESPONSE REGULATOR receiver
GPY25_RS13555	COG3850	Histidine kinase
GPY25_RS13555	COG5002	protein histidine kinase activity
GPY25_RS13605	COG1335	isochorismatase
GPY25_RS13610	COG1136	(ABC) transporter
GPY25_RS13610	COG0577	efflux transmembrane transporter activity
GPY25_RS13615	COG1136	(ABC) transporter
GPY25_RS13615	COG0577	efflux transmembrane transporter activity
GPY25_RS13620	COG1136	(ABC) transporter
GPY25_RS13620	COG0577	efflux transmembrane transporter activity
GPY25_RS13630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS13660	COG3118	belongs to the thioredoxin family
GPY25_RS13665	COG4232	protein-disulfide reductase activity
GPY25_RS13705	COG2863	cytochrome
GPY25_RS13710	COG3258	Cytochrome c
GPY25_RS13715	COG2995	paraquat-inducible protein a
GPY25_RS13720	COG3008	intermembrane lipid transfer
GPY25_RS13720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY25_RS13730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY25_RS13740	COG0463	Glycosyl transferase, family 2
GPY25_RS13755	COG4166	transmembrane transport
GPY25_RS13760	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY25_RS13765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY25_RS13770	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY25_RS13780	COG0539	negative regulation of cytoplasmic translation
GPY25_RS13785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY25_RS13790	COG0616	signal peptide processing
GPY25_RS13795	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS13810	COG0587	DNA-directed DNA polymerase activity
GPY25_RS13815	COG0784	Response regulator, receiver
GPY25_RS13815	COG0835	chemotaxis
GPY25_RS13820	COG1940	carbohydrate kinase activity
GPY25_RS13825	COG0469	pyruvate kinase activity
GPY25_RS13830	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY25_RS13845	COG0733	neurotransmitter:sodium symporter activity
GPY25_RS13865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY25_RS13865	COG1263	PTS System
GPY25_RS13870	COG0084	hydrolase, TatD family'
GPY25_RS13880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY25_RS13885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY25_RS13915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY25_RS13920	COG0416	fatty acid biosynthetic process
GPY25_RS13930	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY25_RS13935	COG0424	maF-like protein
GPY25_RS13940	COG0564	pseudouridine synthase activity
GPY25_RS13945	COG1530	ribonuclease E activity
GPY25_RS13950	COG0659	secondary active sulfate transmembrane transporter activity
GPY25_RS13955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY25_RS13960	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY25_RS13970	COG0572	uridine kinase
GPY25_RS13975	COG0489	protein tyrosine kinase activity
GPY25_RS13980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY25_RS13980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY25_RS13990	COG2186	Transcriptional regulator
GPY25_RS13995	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY25_RS14000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY25_RS14005	COG0653	protein targeting
GPY25_RS14010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY25_RS14015	COG3706	GGDEF domain
GPY25_RS14015	COG0745	RESPONSE REGULATOR receiver
GPY25_RS14020	COG0366	Alpha amylase catalytic
GPY25_RS14025	COG1122	ATPase activity
GPY25_RS14030	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY25_RS14040	COG3092	negative regulation of chromosome organization
GPY25_RS14045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY25_RS14050	COG0857	belongs to the CobB CobQ family
GPY25_RS14050	COG0280	phosphate acetyltransferase
GPY25_RS14055	COG3174	membrane
GPY25_RS14065	COG0435	Glutathione S-transferase
GPY25_RS14075	COG0444	Belongs to the ABC transporter superfamily
GPY25_RS14080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY25_RS14085	COG0601	transmembrane transport
GPY25_RS14095	COG0314	molybdopterin synthase activity
GPY25_RS14100	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY25_RS14105	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY25_RS14110	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY25_RS14115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY25_RS14120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY25_RS14125	COG2198	Histidine kinase
GPY25_RS14130	COG2204	response regulator
GPY25_RS14135	COG0556	nucleotide-excision repair
GPY25_RS14150	COG4657	Part of a membrane complex involved in electron transport
GPY25_RS14155	COG2878	Part of a membrane complex involved in electron transport
GPY25_RS14160	COG4656	Part of a membrane complex involved in electron transport
GPY25_RS14165	COG4658	electron transport chain
GPY25_RS14170	COG4659	FMN binding
GPY25_RS14175	COG4660	Part of a membrane complex involved in electron transport
GPY25_RS14180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY25_RS14185	COG0346	lactoylglutathione lyase activity
GPY25_RS14195	COG2885	chlorophyll binding
GPY25_RS14210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY25_RS14215	COG2056	Na+-H+ antiporter family
GPY25_RS14225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY25_RS14245	COG1454	alcohol dehydrogenase
GPY25_RS14245	COG1012	belongs to the aldehyde dehydrogenase family
GPY25_RS14250	COG2095	MarC family integral membrane protein
GPY25_RS14255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY25_RS14260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY25_RS14265	COG1757	Na H antiporter
GPY25_RS14280	COG3081	Nucleoid-associated protein
GPY25_RS14285	COG3082	Protein of unknown function (DUF1414)
GPY25_RS14290	COG3083	sulfuric ester hydrolase activity
GPY25_RS14300	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY25_RS14320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY25_RS14325	COG0778	Nitroreductase
GPY25_RS14330	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY25_RS14330	COG1902	pentaerythritol trinitrate reductase activity
GPY25_RS14335	COG0616	signal peptide processing
GPY25_RS14340	COG0252	asparaginase activity
GPY25_RS14345	COG3139	Protein of unknown function (DUF1315)
GPY25_RS14355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY25_RS14360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY25_RS14375	COG2226	methyltransferase
GPY25_RS14395	COG1785	Belongs to the alkaline phosphatase family
GPY25_RS14405	COG0346	lactoylglutathione lyase activity
GPY25_RS14410	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY25_RS14415	COG0668	transmembrane transport
GPY25_RS14420	COG2983	Belongs to the UPF0260 family
GPY25_RS14425	COG2261	transglycosylase associated protein
GPY25_RS14440	COG3681	Belongs to the UPF0597 family
GPY25_RS14445	COG0251	oxidation-reduction process
GPY25_RS14450	COG0814	amino acid
GPY25_RS14455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY25_RS14460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY25_RS14465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY25_RS14475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY25_RS14480	COG2832	Protein of unknown function (DUF454)
GPY25_RS14490	COG0745	RESPONSE REGULATOR receiver
GPY25_RS14495	COG0583	DNA-binding transcription factor activity
GPY25_RS14500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY25_RS14505	COG1286	toxin biosynthetic process
GPY25_RS14510	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY25_RS14515	COG0285	dihydrofolate synthase activity
GPY25_RS14520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY25_RS14525	COG0101	tRNA pseudouridine synthase activity
GPY25_RS14535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY25_RS14540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY25_RS14545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY25_RS14550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY25_RS14550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY25_RS14555	COG0431	NADPH-dependent FMN reductase
GPY25_RS14570	COG3101	peptidyl-lysine hydroxylation
GPY25_RS14580	COG2860	membrane
GPY25_RS14585	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY25_RS14590	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY25_RS14595	COG2840	Smr protein MutS2
GPY25_RS14600	COG2062	phosphohistidine phosphatase, SixA
GPY25_RS14615	COG1024	Enoyl-CoA hydratase
GPY25_RS14615	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY25_RS14620	COG0183	Belongs to the thiolase family
GPY25_RS14635	COG2067	long-chain fatty acid transport protein
GPY25_RS14640	COG2067	long-chain fatty acid transport protein
GPY25_RS14645	COG2853	Lipoprotein
GPY25_RS14660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY25_RS14665	COG1138	Cytochrome C-type biogenesis protein
GPY25_RS14670	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY25_RS14675	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY25_RS14680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY25_RS14685	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY25_RS14690	COG4133	protoheme IX ABC transporter activity
GPY25_RS14700	COG0835	chemotaxis
GPY25_RS14710	COG1192	Involved in chromosome partitioning
GPY25_RS14715	COG2201	protein-glutamate methylesterase activity
GPY25_RS14720	COG0643	Histidine kinase
GPY25_RS14720	COG2198	Histidine kinase
GPY25_RS14725	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY25_RS14740	COG0455	bacterial-type flagellum organization
GPY25_RS14760	COG1684	flagellar biosynthetic protein fliR
GPY25_RS14765	COG1987	bacterial-type flagellum assembly
GPY25_RS14815	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY25_RS14825	COG1677	Flagellar hook-basal body complex protein FliE
GPY25_RS14830	COG2204	response regulator
GPY25_RS14835	COG4191	Histidine kinase
GPY25_RS14845	COG1516	flagellar protein fliS
GPY25_RS14855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY25_RS14860	COG1334	flagellar protein FlaG
GPY25_RS14865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS14870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS14880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS14885	COG2837	iron assimilation
GPY25_RS14915	COG1393	Belongs to the ArsC family
GPY25_RS14920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY25_RS14940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY25_RS14945	COG2716	regulation of RNA biosynthetic process
GPY25_RS14950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY25_RS14965	COG4783	chaperone-mediated protein folding
GPY25_RS14970	COG1393	Belongs to the ArsC family
GPY25_RS14990	COG2233	PERMEase
GPY25_RS14995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY25_RS15000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY25_RS15005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY25_RS15010	COG0121	glutamine amidotransferase
GPY25_RS15015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY25_RS15020	COG1960	acyl-CoA dehydrogenase activity
GPY25_RS15035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY25_RS15040	COG0328	RNA-DNA hybrid ribonuclease activity
GPY25_RS15045	COG2226	methyltransferase
GPY25_RS15050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY25_RS15055	COG0741	lytic transglycosylase activity
GPY25_RS15055	COG1388	LysM domain
GPY25_RS15065	COG3021	interspecies interaction between organisms
GPY25_RS15070	COG0347	Belongs to the P(II) protein family
GPY25_RS15080	COG0037	tRNA processing
GPY25_RS15085	COG0825	malonyl-CoA metabolic process
GPY25_RS15090	COG0587	DNA-directed DNA polymerase activity
GPY25_RS15100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY25_RS15105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY25_RS15110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY25_RS15115	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY25_RS15125	COG0750	zinc metalloprotease
GPY25_RS15130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY25_RS15135	COG0575	Belongs to the CDS family
GPY25_RS15140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY25_RS15145	COG0233	cytoplasmic translational termination
GPY25_RS15150	COG0528	UMP kinase activity
GPY25_RS15155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY25_RS15160	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY25_RS15165	COG0024	Methionine aminopeptidase
GPY25_RS15170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY25_RS15180	COG0564	pseudouridine synthase activity
GPY25_RS15185	COG3098	single-species biofilm formation
GPY25_RS15210	COG1671	Belongs to the UPF0178 family
GPY25_RS15215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY25_RS15230	COG0254	rRNA binding
GPY25_RS15235	COG1720	tRNA m6t6A37 methyltransferase activity
GPY25_RS15240	COG0442	prolyl-tRNA aminoacylation
GPY25_RS15260	COG0733	neurotransmitter:sodium symporter activity
GPY25_RS15275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY25_RS15280	COG0514	ATP-dependent DNA helicase (RecQ)
GPY25_RS15285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY25_RS15305	COG2871	sodium ion transport
GPY25_RS15310	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY25_RS15315	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY25_RS15320	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY25_RS15325	COG1805	sodium ion transport
GPY25_RS15330	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY25_RS15335	COG0271	Belongs to the BolA IbaG family
GPY25_RS15340	COG2813	Specifically methylates the guanine in position
GPY25_RS15345	COG3056	Lipoprotein
GPY25_RS15365	COG1595	DNA-templated transcription, initiation
GPY25_RS15390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY25_RS15395	COG0693	protein deglycase activity
GPY25_RS15400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY25_RS15405	COG3706	GGDEF domain
GPY25_RS15410	COG2166	iron-sulfur cluster assembly
GPY25_RS15415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY25_RS15420	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY25_RS15430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY25_RS15430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY25_RS15455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY25_RS15460	COG1074	ATP-dependent DNA helicase activity
GPY25_RS15465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY25_RS15485	COG3141	response to X-ray
GPY25_RS15490	COG2171	N-acyltransferase activity
GPY25_RS15495	COG0584	glycerophosphoryl diester phosphodiesterase
GPY25_RS15500	COG2271	Major facilitator Superfamily
GPY25_RS15515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY25_RS15520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY25_RS15525	COG1349	DNA-binding transcription factor activity
GPY25_RS15530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY25_RS15535	COG0598	Magnesium transport protein CorA
GPY25_RS15550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY25_RS15555	COG1609	Transcriptional regulator
GPY25_RS15560	COG2211	Major facilitator Superfamily
GPY25_RS15575	COG2017	converts alpha-aldose to the beta-anomer
GPY25_RS15580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY25_RS15590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY25_RS15600	COG1609	Transcriptional regulator
GPY25_RS15605	COG3250	beta-galactosidase activity
GPY25_RS15610	COG2731	YhcH YjgK YiaL family protein
GPY25_RS15615	COG0531	amino acid
GPY25_RS15620	COG0583	DNA-binding transcription factor activity
GPY25_RS15680	COG4964	Belongs to the GSP D family
GPY25_RS15705	COG2169	Transcriptional regulator
GPY25_RS15710	COG1022	Amp-dependent synthetase and ligase
GPY25_RS15720	COG0583	DNA-binding transcription factor activity
GPY25_RS15725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY25_RS15730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY25_RS15740	COG0560	Phosphoserine phosphatase
GPY25_RS15750	COG0813	purine-nucleoside phosphorylase activity
GPY25_RS15755	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY25_RS15760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY25_RS15765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY25_RS15770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY25_RS15775	COG0084	hydrolase, TatD family'
GPY25_RS15785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY25_RS15805	COG3153	acetyltransferase
GPY25_RS15830	COG0534	Mate efflux family protein
GPY25_RS15845	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY25_RS15850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY25_RS15855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY25_RS15860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY25_RS15865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY25_RS15870	COG0195	Participates in both transcription termination and antitermination
GPY25_RS15875	COG0779	Required for maturation of 30S ribosomal subunits
GPY25_RS15890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY25_RS15900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY25_RS15905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY25_RS15910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY25_RS15915	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY25_RS15920	COG1534	Rna-binding protein
GPY25_RS15925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY25_RS15930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY25_RS15935	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY25_RS15945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY25_RS15950	COG0739	heme binding
GPY25_RS15955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY25_RS15965	COG0316	Belongs to the HesB IscA family
GPY25_RS15970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY25_RS15975	COG0628	permease
GPY25_RS15980	COG2813	Specifically methylates the guanine in position
GPY25_RS15985	COG0784	Response regulator, receiver
GPY25_RS15985	COG2205	protein histidine kinase activity
GPY25_RS15985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY25_RS15985	COG2198	Histidine kinase
GPY25_RS15990	COG0747	negative chemotaxis
GPY25_RS16000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY25_RS16005	COG0444	Belongs to the ABC transporter superfamily
GPY25_RS16010	COG4608	Belongs to the ABC transporter superfamily
GPY25_RS16020	COG2971	BadF BadG BcrA BcrD
GPY25_RS16035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY25_RS16040	COG3842	ATPase activity
GPY25_RS16050	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY25_RS16055	COG0004	ammonium transporteR
GPY25_RS16065	COG3112	Uncharacterised protein family (UPF0231)
GPY25_RS16070	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY25_RS16075	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY25_RS16080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY25_RS16085	COG1643	Atp-dependent helicase
GPY25_RS16090	COG1489	DNA binding
GPY25_RS16095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY25_RS16105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY25_RS16120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY25_RS16125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY25_RS16130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY25_RS16140	COG1560	Kdo2-lipid A biosynthetic process
GPY25_RS16145	COG0842	Transport permease protein
GPY25_RS16150	COG1131	(ABC) transporter
GPY25_RS16160	COG0659	secondary active sulfate transmembrane transporter activity
GPY25_RS16165	COG0288	reversible hydration of carbon dioxide
GPY25_RS16180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY25_RS16185	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY25_RS16190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY25_RS16195	COG2186	Transcriptional regulator
GPY25_RS16205	COG0157	Belongs to the NadC ModD family
GPY25_RS16210	COG4969	Belongs to the N-Me-Phe pilin family
GPY25_RS16215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY25_RS16220	COG1459	type II secretion system
GPY25_RS16230	COG0237	dephospho-CoA kinase activity
GPY25_RS16235	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY25_RS16240	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY25_RS16245	COG0335	large ribosomal subunit rRNA binding
GPY25_RS16250	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY25_RS16255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY25_RS16260	COG0228	four-way junction DNA binding
GPY25_RS16265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY25_RS16270	COG4137	Cytochrome C assembly protein
GPY25_RS16275	COG4536	flavin adenine dinucleotide binding
GPY25_RS16280	COG1854	S-ribosylhomocysteine lyase activity
GPY25_RS16290	COG2918	glutathione biosynthetic process
GPY25_RS16295	COG0612	Peptidase, M16
GPY25_RS16300	COG1238	metal cluster binding
GPY25_RS16305	COG1063	alcohol dehydrogenase
GPY25_RS16310	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY25_RS16315	COG5016	pyruvate
GPY25_RS16315	COG0511	ligase activity, forming carbon-carbon bonds
GPY25_RS16320	COG3630	sodium ion export across plasma membrane
GPY25_RS16380	COG0527	aspartate kinase activity
GPY25_RS16385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY25_RS16390	COG2137	regulation of response to DNA damage stimulus
GPY25_RS16395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY25_RS16400	COG1546	Belongs to the CinA family
GPY25_RS16405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY25_RS16420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY25_RS16425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY25_RS16430	COG0585	pseudouridine synthase activity
GPY25_RS16435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY25_RS16440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY25_RS16445	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY25_RS16450	COG0148	phosphopyruvate hydratase activity
GPY25_RS16455	COG0504	CTP synthase activity
GPY25_RS16460	COG3956	TIGRFAM MazG family protein
GPY25_RS16465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY25_RS16475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY25_RS16485	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY25_RS16490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY25_RS16495	COG1381	Involved in DNA repair and RecF pathway recombination
GPY25_RS16500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY25_RS16505	COG0571	ribonuclease III activity
GPY25_RS16510	COG0681	Belongs to the peptidase S26 family
GPY25_RS16515	COG0481	GTPase activity
GPY25_RS16520	COG3086	response to oxidative stress
GPY25_RS16530	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY25_RS16535	COG1595	DNA-templated transcription, initiation
GPY25_RS16545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY25_RS16555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY25_RS16560	COG0354	folic acid binding
GPY25_RS16575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY25_RS16580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY25_RS16585	COG3079	Belongs to the UPF0149 family
GPY25_RS16595	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY25_RS16605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY25_RS16610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY25_RS16615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY25_RS16625	COG0583	DNA-binding transcription factor activity
GPY25_RS16635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY25_RS16695	COG3842	ATPase activity
GPY25_RS16725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY25_RS16745	COG3706	GGDEF domain
GPY25_RS16765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS16780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY25_RS16785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY25_RS16805	COG0574	Belongs to the PEP-utilizing enzyme family
GPY25_RS16805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY25_RS16810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY25_RS16815	COG0252	asparaginase activity
GPY25_RS16825	COG0583	DNA-binding transcription factor activity
GPY25_RS16845	COG3122	Protein conserved in bacteria
GPY25_RS16860	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS16870	COG1063	alcohol dehydrogenase
GPY25_RS16875	COG1902	pentaerythritol trinitrate reductase activity
GPY25_RS16890	COG0583	DNA-binding transcription factor activity
GPY25_RS16900	COG0513	Belongs to the DEAD box helicase family
GPY25_RS16945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY25_RS16950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY25_RS16950	COG2207	Transcriptional regulator
GPY25_RS16980	COG2354	Protein conserved in bacteria
GPY25_RS16985	COG0418	dihydroorotase activity
GPY25_RS16995	COG0401	homolog of Blt101
GPY25_RS17005	COG0633	Ferredoxin
GPY25_RS17005	COG3217	Mosc domain protein beta barrel domain protein
GPY25_RS17005	COG0633	Ferredoxin
GPY25_RS17005	COG3217	Mosc domain protein beta barrel domain protein
GPY25_RS17010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY25_RS17015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY25_RS17055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY25_RS17060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY25_RS17070	COG0848	biopolymer transport protein
GPY25_RS17075	COG0811	peptide transport
GPY25_RS17080	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY25_RS17090	COG3721	Heme iron utilization protein
GPY25_RS17095	COG0748	coenzyme F420 binding
GPY25_RS17105	COG0835	chemotaxis
GPY25_RS17105	COG0784	Response regulator, receiver
GPY25_RS17110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY25_RS17125	COG2814	Major facilitator Superfamily
GPY25_RS17160	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY25_RS17165	COG0783	Belongs to the Dps family
GPY25_RS17175	COG0583	DNA-binding transcription factor activity
GPY25_RS17190	COG4934	collagen metabolic process
GPY25_RS17200	COG0366	Alpha amylase catalytic
GPY25_RS17220	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY25_RS17225	COG0589	response to stress
GPY25_RS17230	COG0488	(ABC) transporter
GPY25_RS17235	COG1505	serine-type exopeptidase activity
GPY25_RS17245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS17255	COG2067	long-chain fatty acid transport protein
GPY25_RS17265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY25_RS17275	COG2199	diguanylate cyclase activity
GPY25_RS17275	COG2203	Gaf domain
GPY25_RS17295	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY25_RS17320	COG3383	formate dehydrogenase (NAD+) activity
GPY25_RS17335	COG0842	Transport permease protein
GPY25_RS17340	COG1131	(ABC) transporter
GPY25_RS17355	COG2706	6-phosphogluconolactonase activity
GPY25_RS17365	COG1881	PFAM PEBP family protein
GPY25_RS17375	COG0798	PFAM Bile acid sodium symporter
GPY25_RS17395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY25_RS17400	COG2213	PTS system mannitol-specific
GPY25_RS17405	COG1063	alcohol dehydrogenase
GPY25_RS17415	COG1072	(Pantothenic acid kinase))
GPY25_RS17420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY25_RS17440	COG0814	amino acid
GPY25_RS17480	COG0739	heme binding
GPY25_RS17485	COG5001	Diguanylate cyclase
GPY25_RS17490	COG0583	DNA-binding transcription factor activity
GPY25_RS17495	COG2814	Major facilitator Superfamily
GPY25_RS17520	COG0697	spore germination
GPY25_RS17525	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY25_RS17550	COG2207	Transcriptional regulator
GPY25_RS17555	COG1280	lysine exporter protein (LysE YggA)
GPY25_RS17565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY25_RS17570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY25_RS17580	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY25_RS17605	COG1612	heme a metabolic process
GPY25_RS17610	COG0109	protoheme IX farnesyltransferase activity
GPY25_RS17615	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY25_RS17650	COG1278	Cold shock
GPY25_RS17655	COG3036	rescue of stalled ribosome
GPY25_RS17670	COG2199	diguanylate cyclase activity
GPY25_RS17690	COG1136	(ABC) transporter
GPY25_RS17690	COG0577	efflux transmembrane transporter activity
GPY25_RS17700	COG0840	transmembrane signaling receptor activity
GPY25_RS17705	COG0783	Belongs to the Dps family
GPY25_RS17715	COG2133	pyrroloquinoline quinone binding
GPY25_RS17720	COG1454	alcohol dehydrogenase
GPY25_RS17725	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY25_RS17760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY25_RS17765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY25_RS17770	COG3186	Phenylalanine-4-hydroxylase
GPY25_RS17775	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY25_RS17800	COG3530	Putative quorum-sensing-regulated virulence factor
GPY25_RS17805	COG0513	Belongs to the DEAD box helicase family
GPY25_RS17810	COG4628	conserved protein (DUF2132)
GPY25_RS17815	COG0133	tryptophan synthase activity
GPY25_RS17825	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY25_RS17835	COG0523	cobalamin synthesis protein
GPY25_RS17840	COG0513	Belongs to the DEAD box helicase family
GPY25_RS17860	COG2200	EAL domain
GPY25_RS17865	COG1119	ATPase activity
GPY25_RS17870	COG0840	transmembrane signaling receptor activity
GPY25_RS17895	COG0641	radical SAM
GPY25_RS17915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY25_RS17930	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY25_RS17935	COG0513	Belongs to the DEAD box helicase family
GPY25_RS17940	COG5001	Diguanylate cyclase
GPY25_RS17950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY25_RS17965	COG5413	integral membrane protein
GPY25_RS17975	COG1024	Enoyl-CoA hydratase
GPY25_RS17980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY25_RS17985	COG1960	acyl-CoA dehydrogenase activity
GPY25_RS17995	COG0183	Belongs to the thiolase family
GPY25_RS18010	COG1024	Enoyl-CoA hydratase
GPY25_RS18015	COG1024	Enoyl-CoA hydratase
GPY25_RS18025	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS18030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY25_RS18035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY25_RS18040	COG1845	cytochrome c oxidase, subunit III
GPY25_RS18045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY25_RS18050	COG0109	protoheme IX farnesyltransferase activity
GPY25_RS18055	COG1902	pentaerythritol trinitrate reductase activity
GPY25_RS18065	COG1126	abc transporter atp-binding protein
GPY25_RS18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY25_RS18075	COG4215	(ABC) transporter
GPY25_RS18080	COG4160	amino acid transport
GPY25_RS18095	COG0625	glutathione transferase activity
GPY25_RS18130	COG0443	Heat shock 70 kDa protein
GPY25_RS18135	COG2847	Copper chaperone PCu(A)C
GPY25_RS18160	COG4607	ABC-type enterochelin transport system periplasmic component
GPY25_RS18165	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY25_RS18170	COG4605	iron ion homeostasis
GPY25_RS18175	COG4604	ABC transporter, ATP-binding protein
GPY25_RS18180	COG0789	Transcriptional regulator
GPY25_RS18195	COG4771	TonB-dependent receptor
GPY25_RS18195	COG1629	transport
GPY25_RS18230	COG1289	transmembrane transporter activity
GPY25_RS18235	COG0210	DNA helicase
GPY25_RS18240	COG1803	Methylglyoxal synthase
GPY25_RS18245	COG1879	ABC-type sugar transport system periplasmic component
GPY25_RS18250	COG0784	Response regulator, receiver
GPY25_RS18250	COG2205	protein histidine kinase activity
GPY25_RS18250	COG2198	Histidine kinase
GPY25_RS18265	COG0745	RESPONSE REGULATOR receiver
GPY25_RS18270	COG3119	arylsulfatase activity
GPY25_RS18275	COG3119	arylsulfatase activity
GPY25_RS18290	COG3119	arylsulfatase activity
GPY25_RS18295	COG0641	radical SAM
GPY25_RS18300	COG0714	Associated with various cellular activities
GPY25_RS18330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY25_RS18330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY25_RS18335	COG0583	DNA-binding transcription factor activity
GPY25_RS18340	COG1597	lipid kinase activity
GPY25_RS18345	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY25_RS18365	COG0641	radical SAM
GPY25_RS18395	COG0501	Belongs to the peptidase M48B family
GPY25_RS18400	COG1704	LemA family
GPY25_RS18405	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY25_RS18415	COG0456	acetyltransferase
GPY25_RS18415	COG1214	PFAM Peptidase M22, glycoprotease
GPY25_RS18435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY25_RS18455	COG2207	Transcriptional regulator
GPY25_RS18480	COG4964	Belongs to the GSP D family
GPY25_RS18540	COG0583	DNA-binding transcription factor activity
GPY25_RS18545	COG0583	DNA-binding transcription factor activity
GPY25_RS18560	COG3300	MHYT domain
GPY25_RS18560	COG5001	Diguanylate cyclase
GPY25_RS18565	COG2197	response regulator
GPY25_RS18570	COG3706	GGDEF domain
GPY25_RS18580	COG2197	response regulator
GPY25_RS18605	COG0835	chemotaxis
GPY25_RS18605	COG0784	Response regulator, receiver
GPY25_RS18625	COG2962	Rard protein
GPY25_RS18640	COG0671	phosphoesterase, PA-phosphatase related
GPY25_RS18655	COG2076	Multidrug Resistance protein
GPY25_RS18685	COG0471	metal ion transport
GPY25_RS18690	COG3290	protein histidine kinase activity
GPY25_RS18695	COG4565	transcriptional regulatory protein
GPY25_RS18705	COG0069	glutamate synthase activity
GPY25_RS18705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY25_RS18715	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY25_RS18740	COG1902	pentaerythritol trinitrate reductase activity
GPY25_RS18745	COG0346	lactoylglutathione lyase activity
GPY25_RS18765	COG2239	Acts as a magnesium transporter
GPY25_RS18795	COG0242	peptide deformylase activity
GPY25_RS18840	COG2176	DNA-directed DNA polymerase activity
GPY25_RS18845	COG0583	DNA-binding transcription factor activity
GPY25_RS18850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY25_RS18855	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY25_RS18870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY25_RS18870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY25_RS18875	COG0509	glycine decarboxylation via glycine cleavage system
GPY25_RS18880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY25_RS18920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY25_RS18920	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY25_RS18920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY25_RS18925	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY25_RS18930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY25_RS18930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY25_RS18935	COG1609	Transcriptional regulator
GPY25_RS18955	COG2200	EAL domain
GPY25_RS18955	COG2199	diguanylate cyclase activity
GPY25_RS18955	COG2203	Gaf domain
GPY25_RS18960	COG0765	amino acid transport
GPY25_RS18965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY25_RS18970	COG0765	amino acid transport
GPY25_RS18975	COG1126	abc transporter atp-binding protein
GPY25_RS18980	COG0469	pyruvate kinase activity
GPY25_RS18985	COG2271	Major facilitator Superfamily
GPY25_RS18990	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY25_RS19010	COG1979	alcohol dehydrogenase
GPY25_RS19015	COG2207	Transcriptional regulator
GPY25_RS19030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY25_RS19035	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY25_RS19040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY25_RS19060	COG3437	response regulator, receiver
GPY25_RS19060	COG0784	Response regulator, receiver
GPY25_RS19070	COG0546	phosphoglycolate phosphatase activity
GPY25_RS19075	COG0840	transmembrane signaling receptor activity
GPY25_RS19085	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY25_RS19090	COG0513	Belongs to the DEAD box helicase family
GPY25_RS19095	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY25_RS19110	COG3038	cytochrome b561
GPY25_RS19115	COG2353	YceI-like domain
GPY25_RS19120	COG2116	formate transmembrane transporter activity
GPY25_RS19125	COG0583	DNA-binding transcription factor activity
GPY25_RS19135	COG3593	DNA synthesis involved in DNA repair
GPY25_RS19140	COG0737	Belongs to the 5'-nucleotidase family
GPY25_RS19145	COG0861	Integral membrane protein TerC family
GPY25_RS19160	COG1943	Transposase
GPY25_RS19165	COG2267	carboxylic ester hydrolase activity
GPY25_RS19170	COG2067	long-chain fatty acid transport protein
GPY25_RS19185	COG2050	protein possibly involved in aromatic compounds catabolism
GPY25_RS19195	COG4533	DNA binding
GPY25_RS19220	COG0484	heat shock protein binding
GPY25_RS19230	COG5001	Diguanylate cyclase
GPY25_RS19230	COG3300	MHYT domain
GPY25_RS19235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY25_RS19245	COG4181	ATPase activity
GPY25_RS19250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY25_RS19260	COG1984	allophanate hydrolase subunit 2
GPY25_RS19265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY25_RS19270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY25_RS19275	COG5002	protein histidine kinase activity
GPY25_RS19275	COG3447	MASE1 domain protein
GPY25_RS19275	COG5001	Diguanylate cyclase
GPY25_RS19280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY25_RS19290	COG4771	TonB-dependent receptor
GPY25_RS19290	COG1629	transport
GPY25_RS19295	COG0583	DNA-binding transcription factor activity
GPY25_RS19300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY25_RS19300	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY25_RS19300	COG1042	CoA-binding domain protein
GPY25_RS19310	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY25_RS19320	COG0023	Translation Initiation Factor
GPY25_RS19335	COG0589	response to stress
GPY25_RS19340	COG3140	Belongs to the UPF0181 family
GPY25_RS19365	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY25_RS19370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY25_RS19385	COG3706	GGDEF domain
GPY25_RS19385	COG0745	RESPONSE REGULATOR receiver
GPY25_RS19395	COG4251	negative regulation of phosphorylation
GPY25_RS19395	COG5001	Diguanylate cyclase
GPY25_RS19395	COG3706	GGDEF domain
GPY25_RS19395	COG2203	Gaf domain
GPY25_RS19405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY25_RS19410	COG4149	molybdate abc transporter
GPY25_RS19415	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY25_RS19420	COG1492	cobalamin metabolic process
GPY25_RS19425	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY25_RS19435	COG4067	protein conserved in archaea
GPY25_RS19435	COG0189	ligase activity
GPY25_RS19455	COG0534	Mate efflux family protein
GPY25_RS19460	COG0602	queuosine metabolic process
GPY25_RS19465	COG1328	CTP reductase activity
GPY25_RS19480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY25_RS19510	COG0243	molybdopterin cofactor binding
GPY25_RS19520	COG0583	DNA-binding transcription factor activity
GPY25_RS19525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY25_RS19535	COG2197	response regulator
GPY25_RS19540	COG3851	Histidine kinase
GPY25_RS19545	COG2271	Major facilitator Superfamily
GPY25_RS19570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY25_RS19575	COG3118	belongs to the thioredoxin family
GPY25_RS19580	COG2814	Major facilitator Superfamily
GPY25_RS19590	COG0534	Mate efflux family protein
GPY25_RS19620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY25_RS19640	COG2116	formate transmembrane transporter activity
GPY25_RS19645	COG2146	nitrite reductase [NAD(P)H] activity
GPY25_RS19650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY25_RS19655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY25_RS19695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY25_RS19695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY25_RS19740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY25_RS19760	COG0277	FAD linked oxidase domain protein
GPY25_RS19765	COG0583	DNA-binding transcription factor activity
GPY25_RS19785	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY25_RS19800	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY25_RS19815	COG1288	antiporter activity
GPY25_RS19825	COG2814	Major facilitator Superfamily
GPY25_RS19835	COG3040	lipid binding
GPY25_RS19860	COG0420	3'-5' exonuclease activity
GPY25_RS19875	COG3501	Rhs element vgr protein
GPY25_RS19930	COG0631	protein serine/threonine phosphatase activity
GPY25_RS19965	COG2815	serine threonine protein kinase
GPY25_RS19965	COG0515	serine threonine protein kinase
GPY25_RS20020	COG2146	nitrite reductase [NAD(P)H] activity
GPY25_RS20020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY25_RS20025	COG1116	anion transmembrane transporter activity
GPY25_RS20030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY25_RS20035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY25_RS20035	COG1116	anion transmembrane transporter activity
GPY25_RS20045	COG3707	response regulator
GPY25_RS20065	COG1648	precorrin-2 dehydrogenase activity
GPY25_RS20065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY25_RS20070	COG0243	molybdopterin cofactor binding
GPY25_RS20075	COG0456	acetyltransferase
GPY25_RS20080	COG0814	amino acid
GPY25_RS20090	COG3706	GGDEF domain
GPY25_RS20090	COG0745	RESPONSE REGULATOR receiver
GPY25_RS20110	COG1785	Belongs to the alkaline phosphatase family
GPY25_RS20125	COG0745	RESPONSE REGULATOR receiver
GPY25_RS20145	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY25_RS20160	COG1609	Transcriptional regulator
GPY25_RS20165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY25_RS20170	COG1879	ABC-type sugar transport system periplasmic component
GPY25_RS20175	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY25_RS20180	COG1129	ABC transporter
GPY25_RS20185	COG1869	D-ribose catabolic process
GPY25_RS20190	COG5001	Diguanylate cyclase
GPY25_RS20195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY25_RS20255	COG2205	protein histidine kinase activity
GPY25_RS20255	COG0784	Response regulator, receiver
GPY25_RS20275	COG5001	Diguanylate cyclase
GPY25_RS20275	COG3300	MHYT domain
GPY25_RS20285	COG0330	HflC and HflK could
GPY25_RS20300	COG4175	Glycine betaine
GPY25_RS20300	COG0517	IMP dehydrogenase activity
GPY25_RS20305	COG4176	ABC-type proline glycine betaine transport system permease component
GPY25_RS20320	COG1012	belongs to the aldehyde dehydrogenase family
GPY25_RS20325	COG1309	transcriptional regulator
GPY25_RS20330	COG3706	GGDEF domain
GPY25_RS20355	COG1024	Enoyl-CoA hydratase
GPY25_RS20360	COG1960	acyl-CoA dehydrogenase activity
GPY25_RS20370	COG0183	Belongs to the thiolase family
GPY25_RS20380	COG1960	acyl-CoA dehydrogenase activity
GPY25_RS20385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY25_RS20395	COG0439	Biotin carboxylase
GPY25_RS20405	COG2205	protein histidine kinase activity
GPY25_RS20405	COG3437	response regulator, receiver
GPY25_RS20405	COG3850	Histidine kinase
GPY25_RS20405	COG4999	Histidine kinase
GPY25_RS20420	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY25_RS20420	COG3264	Mechanosensitive ion channel
GPY25_RS20430	COG0110	maltose O-acetyltransferase activity
GPY25_RS20435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY25_RS20440	COG1271	oxidase subunit
GPY25_RS20445	COG1294	oxidase, subunit
GPY25_RS20455	COG0384	phenazine biosynthesis protein PhzF
GPY25_RS20460	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY25_RS20465	COG0789	Transcriptional regulator
GPY25_RS20475	COG3474	cytochrome
GPY25_RS20480	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY25_RS20485	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY25_RS20485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY25_RS20555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY25_RS20560	COG0516	GMP reductase activity
GPY25_RS20565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY25_RS20565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY25_RS20580	COG4989	oxidoreductase activity
GPY25_RS20595	COG0038	chloride channel
GPY25_RS20605	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY25_RS20610	COG0302	gtp cyclohydrolase
GPY25_RS20620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY25_RS20640	COG2897	thiosulfate sulfurtransferase activity
GPY25_RS20665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY25_RS20670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY25_RS20675	COG0840	transmembrane signaling receptor activity
GPY25_RS20685	COG2814	Major facilitator Superfamily
GPY25_RS20690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY25_RS20700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY25_RS20710	COG0840	transmembrane signaling receptor activity
GPY25_RS20730	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY25_RS20745	COG2197	response regulator
GPY25_RS20750	COG3850	Histidine kinase
GPY25_RS20755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY25_RS20765	COG0243	molybdopterin cofactor binding
GPY25_RS20775	COG3005	denitrification pathway
GPY25_RS20795	COG0183	Belongs to the thiolase family
GPY25_RS20815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY25_RS20820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY25_RS20845	COG1522	sequence-specific DNA binding
GPY25_RS20865	COG1566	PFAM secretion protein HlyD family protein
GPY25_RS20875	COG0784	Response regulator, receiver
GPY25_RS20875	COG2205	protein histidine kinase activity
GPY25_RS20880	COG1879	ABC-type sugar transport system periplasmic component
GPY25_RS20885	COG2827	Endonuclease containing a URI domain
GPY25_RS20890	COG3132	Protein of unknown function, DUF480
GPY25_RS20905	COG2926	Belongs to the UPF0265 family
GPY25_RS20910	COG0534	Mate efflux family protein
GPY25_RS20915	COG0673	inositol 2-dehydrogenase activity
GPY25_RS20920	COG0784	Response regulator, receiver
GPY25_RS20920	COG2205	protein histidine kinase activity
GPY25_RS20920	COG5002	protein histidine kinase activity
GPY25_RS20945	COG1522	sequence-specific DNA binding
GPY25_RS20955	COG0531	amino acid
GPY25_RS20970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY25_RS20975	COG2239	Acts as a magnesium transporter
GPY25_RS20990	COG0402	S-adenosylhomocysteine deaminase activity
GPY25_RS21000	COG1418	mRNA catabolic process
GPY25_RS21015	COG2814	Major facilitator Superfamily
GPY25_RS21025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY25_RS21045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY25_RS21065	COG4221	oxidoreductase activity
GPY25_RS21070	COG0745	RESPONSE REGULATOR receiver
GPY25_RS21075	COG2205	protein histidine kinase activity
GPY25_RS21085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY25_RS21090	COG2194	sulfuric ester hydrolase activity
GPY25_RS21095	COG0673	inositol 2-dehydrogenase activity
GPY25_RS21120	COG1846	Transcriptional regulator
GPY25_RS21130	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY25_RS21135	COG1741	Belongs to the pirin family
GPY25_RS21140	COG1278	Cold shock
GPY25_RS21160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY25_RS21185	COG1686	Belongs to the peptidase S11 family
GPY25_RS21195	COG0625	glutathione transferase activity
GPY25_RS21205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY25_RS21230	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS21250	COG3746	phosphate-selective porin O and P
GPY25_RS21270	COG0183	Belongs to the thiolase family
GPY25_RS21350	COG0804	urea catabolic process
GPY25_RS21370	COG0747	negative chemotaxis
GPY25_RS21380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY25_RS21385	COG4172	Belongs to the ABC transporter superfamily
GPY25_RS21395	COG2207	Transcriptional regulator
GPY25_RS21415	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY25_RS21505	COG4790	Type iii secretion
GPY25_RS21520	COG3710	Transcriptional regulator
GPY25_RS21550	COG4792	protein secretion
GPY25_RS21555	COG4789	Type iii secretion
GPY25_RS21660	COG2202	Pas domain
GPY25_RS21660	COG2200	EAL domain
GPY25_RS21660	COG2199	diguanylate cyclase activity
GPY25_RS21705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY25_RS21795	COG3833	ABC-type maltose transport systems, permease component
GPY25_RS21800	COG1175	transmembrane transport
GPY25_RS21810	COG3842	ATPase activity
GPY25_RS21875	COG1309	transcriptional regulator
GPY25_RS21880	COG2130	NADP-dependent
GPY25_RS21890	COG0753	catalase activity
GPY25_RS21895	COG2084	Dehydrogenase
GPY25_RS21900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY25_RS21905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY25_RS21915	COG2207	Transcriptional regulator
GPY25_RS21920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY25_RS21920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY25_RS21920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY25_RS21935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY25_RS21940	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY25_RS21945	COG5001	Diguanylate cyclase
GPY25_RS21945	COG3300	MHYT domain
GPY25_RS21950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY25_RS21955	COG0569	domain protein
GPY25_RS21965	COG5002	protein histidine kinase activity
GPY25_RS21970	COG1132	(ABC) transporter
GPY25_RS21975	COG4774	siderophore transport
GPY25_RS21980	COG1120	ATPase activity
GPY25_RS21985	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY25_RS22035	COG2197	response regulator
GPY25_RS22045	COG0840	transmembrane signaling receptor activity
GPY25_RS22055	COG0714	Associated with various cellular activities
GPY25_RS22075	COG2304	oxidoreductase activity
GPY25_RS22090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY25_RS22095	COG0581	inorganic phosphate transmembrane transporter activity
GPY25_RS22100	COG0573	inorganic phosphate transmembrane transporter activity
GPY25_RS22105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY25_RS22130	COG4771	TonB-dependent receptor
GPY25_RS22135	COG1770	oligopeptidase
GPY25_RS22140	COG0513	Belongs to the DEAD box helicase family
GPY25_RS22150	COG1388	LysM domain
GPY25_RS22150	COG1376	ErfK ybiS ycfS ynhG family protein
GPY25_RS22155	COG0415	Belongs to the DNA photolyase family
GPY25_RS22160	COG0789	Transcriptional regulator
GPY25_RS22165	COG3272	Protein of unknown function (DUF1722)
GPY25_RS22175	COG0813	purine-nucleoside phosphorylase activity
GPY25_RS22190	COG3706	GGDEF domain
GPY25_RS22200	COG1566	PFAM secretion protein HlyD family protein
GPY25_RS22205	COG4720	Psort location CytoplasmicMembrane, score
GPY25_RS22210	COG1122	ATPase activity
GPY25_RS22225	COG0348	domain, Protein
GPY25_RS22230	COG0437	4 iron, 4 sulfur cluster binding
GPY25_RS22235	COG1247	-acetyltransferase
GPY25_RS22265	COG1067	ATP-dependent peptidase activity
GPY25_RS22275	COG4172	Belongs to the ABC transporter superfamily
GPY25_RS22280	COG1505	serine-type exopeptidase activity
GPY25_RS22285	COG0583	DNA-binding transcription factor activity
GPY25_RS22290	COG1620	l-lactate permease
GPY25_RS22295	COG1304	FMN binding
GPY25_RS22305	COG0668	transmembrane transport
GPY25_RS22340	COG1063	alcohol dehydrogenase
GPY25_RS22345	COG0156	8-amino-7-oxononanoate synthase activity
GPY25_RS22355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY25_RS22375	COG0745	RESPONSE REGULATOR receiver
GPY25_RS22410	COG0346	lactoylglutathione lyase activity
GPY25_RS22430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY25_RS22470	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY25_RS22485	COG2204	response regulator
GPY25_RS22510	COG1987	bacterial-type flagellum assembly
GPY25_RS22520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY25_RS22535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS22545	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY25_RS22550	COG1516	flagellar protein fliS
GPY25_RS22565	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY25_RS22570	COG1191	sigma factor activity
GPY25_RS22575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY25_RS22580	COG1360	Flagellar Motor Protein
GPY25_RS22635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY25_RS22640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY25_RS22650	COG0454	-acetyltransferase
GPY25_RS22665	COG2814	Major facilitator Superfamily
GPY25_RS22710	COG0628	permease
GPY25_RS22715	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY25_RS22725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY25_RS22735	COG4628	conserved protein (DUF2132)
GPY25_RS22740	COG0583	DNA-binding transcription factor activity
GPY25_RS22765	COG1686	Belongs to the peptidase S11 family
GPY25_RS22785	COG3397	chitin binding
GPY25_RS22790	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY25_RS22795	COG2095	MarC family integral membrane protein
GPY25_RS22815	COG3206	protein involved in exopolysaccharide biosynthesis
GPY25_RS22815	COG0489	protein tyrosine kinase activity
GPY25_RS22830	COG0583	DNA-binding transcription factor activity
GPY25_RS22840	COG1301	dicarboxylic acid transport
GPY25_RS22845	COG3339	Conserved Protein
GPY25_RS22850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY25_RS22855	COG0700	Nucleoside recognition
GPY25_RS22860	COG3366	ferrous iron transmembrane transporter activity
GPY25_RS22875	COG0366	Alpha amylase catalytic
GPY25_RS22880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY25_RS22885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY25_RS22890	COG1640	4-alpha-glucanotransferase
GPY25_RS22895	COG0058	SHG alpha-glucan phosphorylase activity
GPY25_RS22910	COG2909	trisaccharide binding
GPY25_RS22925	COG1999	signal sequence binding
GPY25_RS22935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY25_RS22935	COG1263	PTS System
GPY25_RS22940	COG1162	GTPase activity
GPY25_RS22945	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY25_RS22955	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY25_RS22965	COG0531	amino acid
GPY25_RS22970	COG1982	Orn Lys Arg decarboxylase major
GPY25_RS22990	COG2356	endonuclease I
GPY25_RS23015	COG4580	involved in the transport of maltose and maltodextrins
GPY25_RS23040	COG0739	heme binding
GPY25_RS23050	COG0612	Peptidase, M16
GPY25_RS23055	COG0840	transmembrane signaling receptor activity
GPY25_RS23060	COG1120	ATPase activity
GPY25_RS23065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY25_RS23070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY25_RS23075	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY25_RS23080	COG4772	TonB-dependent receptor
GPY25_RS23105	COG4264	IucA IucC family
GPY25_RS23110	COG0019	diaminopimelate decarboxylase activity
GPY25_RS23115	COG1653	transport
GPY25_RS23125	COG0745	RESPONSE REGULATOR receiver
GPY25_RS23150	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY25_RS23155	COG1129	ABC transporter
GPY25_RS23160	COG1879	ABC-type sugar transport system periplasmic component
GPY25_RS23165	COG1069	ribulokinase activity
GPY25_RS23175	COG2160	L-arabinose isomerase activity
GPY25_RS23200	COG1764	response to oxidative stress
GPY25_RS23205	COG1846	Transcriptional regulator
GPY25_RS23210	COG0450	alkyl hydroperoxide reductase
GPY25_RS23215	COG3634	alkyl hydroperoxide reductase activity
GPY25_RS23245	COG1595	DNA-templated transcription, initiation
GPY25_RS23260	COG0840	transmembrane signaling receptor activity
GPY25_RS23265	COG0583	DNA-binding transcription factor activity
GPY25_RS23270	COG1486	melibiose metabolic process
GPY25_RS23285	COG2258	MOSC domain
GPY25_RS23290	COG0513	Belongs to the DEAD box helicase family
GPY25_RS23300	COG2186	Transcriptional regulator
GPY25_RS23310	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY25_RS23320	COG0246	Mannitol dehydrogenase
GPY25_RS23325	COG1904	glucuronate isomerase
GPY25_RS23330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY25_RS23335	COG0800	Aldolase
GPY25_RS23360	COG2207	Transcriptional regulator
GPY25_RS23370	COG1132	(ABC) transporter
GPY25_RS23415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY25_RS23445	COG0259	pyridoxamine-phosphate oxidase activity
GPY25_RS23490	COG4166	transmembrane transport
GPY25_RS23510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY25_RS23515	COG1263	PTS System
GPY25_RS23515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY25_RS23520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY25_RS23525	COG3340	Belongs to the peptidase S51 family
GPY25_RS23545	COG1444	tRNA N-acetyltransferase activity
GPY25_RS23570	COG4608	Belongs to the ABC transporter superfamily
GPY25_RS23575	COG0444	Belongs to the ABC transporter superfamily
GPY25_RS23585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY25_RS23585	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY25_RS23610	COG0217	transcriptional regulatory protein
GPY25_RS23615	COG0772	Belongs to the SEDS family
GPY25_RS23630	COG1136	(ABC) transporter
GPY25_RS23650	COG3275	phosphorelay sensor kinase activity
GPY25_RS23655	COG3279	Response regulator of the LytR AlgR family
GPY25_RS23665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY25_RS23700	COG0786	glutamate:sodium symporter activity
GPY25_RS23710	COG1131	(ABC) transporter
GPY25_RS23715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY25_RS23720	COG0786	glutamate:sodium symporter activity
GPY25_RS23735	COG0363	glucosamine-6-phosphate deaminase activity
GPY25_RS23755	COG1741	Belongs to the pirin family
GPY25_RS23760	COG2259	Doxx family
GPY25_RS23775	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY25_RS23780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY25_RS23790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY25_RS23830	COG3123	guanosine phosphorylase activity
GPY25_RS23840	COG5001	Diguanylate cyclase
GPY25_RS23850	COG0534	Mate efflux family protein
GPY25_RS23855	COG0564	pseudouridine synthase activity
GPY25_RS23870	COG0583	DNA-binding transcription factor activity
GPY25_RS23875	COG0561	phosphatase activity
GPY25_RS23885	COG2199	diguanylate cyclase activity
GPY25_RS23900	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY25_RS23905	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY25_RS23910	COG0583	DNA-binding transcription factor activity
GPY25_RS23925	COG1414	Transcriptional regulator
GPY25_RS23930	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS23940	COG1917	Cupin 2, conserved barrel domain protein
GPY25_RS23955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY25_RS23960	COG0800	Aldolase
GPY25_RS23980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY25_RS23985	COG0823	Involved in the tonB-independent uptake of proteins
GPY25_RS23990	COG2375	cellular response to nickel ion
GPY25_RS24020	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY25_RS24025	COG3047	cAMP biosynthetic process
GPY25_RS24055	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY25_RS24055	COG3408	Glycogen debranching enzyme
GPY25_RS24060	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GPY25_RS24070	COG0583	DNA-binding transcription factor activity
GPY25_RS24080	COG0583	DNA-binding transcription factor activity
GPY25_RS24095	COG0546	phosphoglycolate phosphatase activity
GPY25_RS24120	COG3835	regulator
GPY25_RS24125	COG2610	gluconate transmembrane transporter activity
GPY25_RS24130	COG1929	Belongs to the glycerate kinase type-1 family
GPY25_RS24135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY25_RS24155	COG0454	-acetyltransferase
GPY25_RS24155	COG0456	acetyltransferase
GPY25_RS24170	COG1028	Short-chain dehydrogenase reductase Sdr
GPY25_RS24180	COG3005	denitrification pathway
GPY25_RS24185	COG0243	molybdopterin cofactor binding
GPY25_RS24195	COG0352	thiamine-phosphate diphosphorylase activity
GPY25_RS24200	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY25_RS24205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY25_RS24210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY25_RS24215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY25_RS24220	COG1116	anion transmembrane transporter activity
GPY25_RS24225	COG0351	phosphomethylpyrimidine kinase
GPY25_RS24235	COG0312	modulator of DNA gyrase
GPY25_RS24240	COG0312	modulator of DNA gyrase
GPY25_RS24245	COG1901	pseudouridine methyltransferase
GPY25_RS24305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY25_RS24315	COG0584	glycerophosphoryl diester phosphodiesterase
GPY25_RS24325	COG0745	RESPONSE REGULATOR receiver
GPY25_RS24345	COG0811	peptide transport
GPY25_RS24350	COG0811	peptide transport
GPY25_RS24355	COG0848	biopolymer transport protein
GPY25_RS24400	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY25_RS24405	COG1121	(ABC) transporter
GPY25_RS24410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY25_RS24425	COG1770	oligopeptidase
GPY25_RS24430	COG2814	Major facilitator Superfamily
GPY25_RS24435	COG0010	Belongs to the arginase family
GPY25_RS24440	COG1166	arginine decarboxylase activity
GPY25_RS24450	COG4067	protein conserved in archaea
GPY25_RS24450	COG0189	ligase activity
GPY25_RS24455	COG0189	ligase activity
GPY25_RS24460	COG0583	DNA-binding transcription factor activity
GPY25_RS24505	COG3706	GGDEF domain
GPY25_RS24535	COG0579	oxidoreductase
GPY25_RS24545	COG3033	Beta-eliminating lyase
GPY25_RS24565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY25_RS24575	COG3145	DNA-N1-methyladenine dioxygenase activity
GPY25_RS24580	COG3706	GGDEF domain
GPY25_RS24585	COG0840	transmembrane signaling receptor activity
GPY25_RS24600	COG3706	GGDEF domain
GPY25_RS24605	COG0415	Belongs to the DNA photolyase family
GPY25_RS24610	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY25_RS24625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY25_RS24625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY25_RS24630	COG1765	OsmC-like protein
GPY25_RS24635	COG0110	maltose O-acetyltransferase activity
GPY25_RS24675	COG1011	Hydrolase
GPY25_RS24690	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY25_RS24700	COG2067	long-chain fatty acid transport protein
GPY25_RS24705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY25_RS24710	COG0577	efflux transmembrane transporter activity
GPY25_RS24710	COG1136	(ABC) transporter
GPY25_RS24720	COG3240	lipase activity
GPY25_RS24750	COG1609	Transcriptional regulator
GPY25_RS24755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY25_RS24765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY25_RS24770	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY25_RS24780	COG3842	ATPase activity
GPY25_RS24805	COG2990	Protein conserved in bacteria
GPY25_RS24815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY25_RS24820	COG2866	Carboxypeptidase
GPY25_RS24835	COG0583	DNA-binding transcription factor activity
GPY25_RS24860	COG1760	l-serine dehydratase
GPY25_RS24880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY25_RS24890	COG0741	lytic transglycosylase activity
GPY25_RS24910	COG1815	bacterial-type flagellum-dependent cell motility
GPY25_RS24915	COG1558	bacterial-type flagellum-dependent cell motility
GPY25_RS24920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY25_RS24925	COG1749	Flagellar hook protein flgE
GPY25_RS24930	COG4787	bacterial-type flagellum-dependent cell motility
GPY25_RS24935	COG4786	Flagellar basal body rod
GPY25_RS24940	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY25_RS24945	COG1706	bacterial-type flagellum-dependent cell motility
GPY25_RS24960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY25_RS24980	COG1304	FMN binding
GPY25_RS25010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY25_RS25020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY25_RS25025	COG0459	protein refolding
GPY25_RS25040	COG1280	lysine exporter protein (LysE YggA)
GPY25_RS25060	COG1309	transcriptional regulator
GPY25_RS25070	COG0737	Belongs to the 5'-nucleotidase family
GPY25_RS25075	COG2070	2-Nitropropane dioxygenase
GPY25_RS25080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY25_RS25095	COG0346	lactoylglutathione lyase activity
GPY25_RS25100	COG1349	DNA-binding transcription factor activity
GPY25_RS25110	COG0753	catalase activity
GPY25_RS25120	COG1335	isochorismatase
GPY25_RS25130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY25_RS25155	COG0583	DNA-binding transcription factor activity
GPY25_RS25170	COG3713	MltA-interacting MipA family protein
GPY25_RS25180	COG3015	lipoprotein NlpE involved in copper resistance
GPY25_RS25190	COG1342	Belongs to the UPF0251 family
GPY25_RS25215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY25_RS25225	COG4948	Mandelate Racemase Muconate Lactonizing
GPY25_RS25235	COG0583	DNA-binding transcription factor activity