locus-tag	class	description
GPY34_RS00025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY34_RS00030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY34_RS00035	COG2146	nitrite reductase [NAD(P)H] activity
GPY34_RS00040	COG2116	formate transmembrane transporter activity
GPY34_RS00060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY34_RS00090	COG0534	Mate efflux family protein
GPY34_RS00100	COG2814	Major facilitator Superfamily
GPY34_RS00105	COG3118	belongs to the thioredoxin family
GPY34_RS00110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY34_RS00135	COG2271	Major facilitator Superfamily
GPY34_RS00140	COG3851	Histidine kinase
GPY34_RS00145	COG2197	response regulator
GPY34_RS00155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY34_RS00160	COG0583	DNA-binding transcription factor activity
GPY34_RS00170	COG0243	molybdopterin cofactor binding
GPY34_RS00200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY34_RS00215	COG1328	CTP reductase activity
GPY34_RS00220	COG0602	queuosine metabolic process
GPY34_RS00225	COG0534	Mate efflux family protein
GPY34_RS00245	COG4067	protein conserved in archaea
GPY34_RS00245	COG0189	ligase activity
GPY34_RS00255	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY34_RS00260	COG1492	cobalamin metabolic process
GPY34_RS00265	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY34_RS00270	COG4149	molybdate abc transporter
GPY34_RS00275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY34_RS00285	COG3706	GGDEF domain
GPY34_RS00285	COG2203	Gaf domain
GPY34_RS00285	COG4251	negative regulation of phosphorylation
GPY34_RS00285	COG5001	Diguanylate cyclase
GPY34_RS00295	COG3706	GGDEF domain
GPY34_RS00295	COG0745	RESPONSE REGULATOR receiver
GPY34_RS00310	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY34_RS00315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY34_RS00340	COG3140	Belongs to the UPF0181 family
GPY34_RS00345	COG0589	response to stress
GPY34_RS00360	COG0023	Translation Initiation Factor
GPY34_RS00370	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY34_RS00380	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY34_RS00380	COG1042	CoA-binding domain protein
GPY34_RS00380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY34_RS00385	COG0583	DNA-binding transcription factor activity
GPY34_RS00390	COG1629	transport
GPY34_RS00390	COG4771	TonB-dependent receptor
GPY34_RS00400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY34_RS00405	COG3447	MASE1 domain protein
GPY34_RS00405	COG5002	protein histidine kinase activity
GPY34_RS00405	COG5001	Diguanylate cyclase
GPY34_RS00410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY34_RS00415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY34_RS00420	COG1984	allophanate hydrolase subunit 2
GPY34_RS00430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY34_RS00435	COG4181	ATPase activity
GPY34_RS00445	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY34_RS00450	COG3300	MHYT domain
GPY34_RS00450	COG5001	Diguanylate cyclase
GPY34_RS00460	COG0484	heat shock protein binding
GPY34_RS00485	COG4533	DNA binding
GPY34_RS00495	COG2050	protein possibly involved in aromatic compounds catabolism
GPY34_RS00510	COG2067	long-chain fatty acid transport protein
GPY34_RS00515	COG2267	carboxylic ester hydrolase activity
GPY34_RS00520	COG1943	Transposase
GPY34_RS00535	COG0861	Integral membrane protein TerC family
GPY34_RS00540	COG0737	Belongs to the 5'-nucleotidase family
GPY34_RS00545	COG3593	DNA synthesis involved in DNA repair
GPY34_RS00555	COG0583	DNA-binding transcription factor activity
GPY34_RS00560	COG2116	formate transmembrane transporter activity
GPY34_RS00565	COG2353	YceI-like domain
GPY34_RS00570	COG3038	cytochrome b561
GPY34_RS00585	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY34_RS00590	COG0513	Belongs to the DEAD box helicase family
GPY34_RS00595	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY34_RS00605	COG0840	transmembrane signaling receptor activity
GPY34_RS00610	COG0546	phosphoglycolate phosphatase activity
GPY34_RS00620	COG0784	Response regulator, receiver
GPY34_RS00620	COG3437	response regulator, receiver
GPY34_RS00640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY34_RS00645	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY34_RS00650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY34_RS00665	COG2207	Transcriptional regulator
GPY34_RS00670	COG1979	alcohol dehydrogenase
GPY34_RS00690	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY34_RS00695	COG2271	Major facilitator Superfamily
GPY34_RS00700	COG0469	pyruvate kinase activity
GPY34_RS00705	COG1126	abc transporter atp-binding protein
GPY34_RS00710	COG0765	amino acid transport
GPY34_RS00715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY34_RS00720	COG0765	amino acid transport
GPY34_RS00725	COG2203	Gaf domain
GPY34_RS00725	COG2200	EAL domain
GPY34_RS00725	COG2199	diguanylate cyclase activity
GPY34_RS00745	COG1609	Transcriptional regulator
GPY34_RS00750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY34_RS00750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY34_RS00755	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY34_RS00760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY34_RS00760	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY34_RS00760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY34_RS00800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY34_RS00805	COG0509	glycine decarboxylation via glycine cleavage system
GPY34_RS00810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY34_RS00810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY34_RS00825	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY34_RS00830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY34_RS00835	COG0583	DNA-binding transcription factor activity
GPY34_RS00840	COG2176	DNA-directed DNA polymerase activity
GPY34_RS00885	COG0242	peptide deformylase activity
GPY34_RS00915	COG2239	Acts as a magnesium transporter
GPY34_RS00935	COG0346	lactoylglutathione lyase activity
GPY34_RS00940	COG1902	pentaerythritol trinitrate reductase activity
GPY34_RS00965	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY34_RS00975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY34_RS00975	COG0069	glutamate synthase activity
GPY34_RS00985	COG4565	transcriptional regulatory protein
GPY34_RS00990	COG3290	protein histidine kinase activity
GPY34_RS00995	COG0471	metal ion transport
GPY34_RS01025	COG2076	Multidrug Resistance protein
GPY34_RS01040	COG0671	phosphoesterase, PA-phosphatase related
GPY34_RS01055	COG2962	Rard protein
GPY34_RS01075	COG0784	Response regulator, receiver
GPY34_RS01075	COG0835	chemotaxis
GPY34_RS01100	COG2197	response regulator
GPY34_RS01110	COG3706	GGDEF domain
GPY34_RS01115	COG2197	response regulator
GPY34_RS01120	COG5001	Diguanylate cyclase
GPY34_RS01120	COG3300	MHYT domain
GPY34_RS01135	COG0583	DNA-binding transcription factor activity
GPY34_RS01140	COG0583	DNA-binding transcription factor activity
GPY34_RS01200	COG4964	Belongs to the GSP D family
GPY34_RS01225	COG2207	Transcriptional regulator
GPY34_RS01245	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY34_RS01265	COG0456	acetyltransferase
GPY34_RS01265	COG1214	PFAM Peptidase M22, glycoprotease
GPY34_RS01275	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY34_RS01280	COG1704	LemA family
GPY34_RS01285	COG0501	Belongs to the peptidase M48B family
GPY34_RS01315	COG0641	radical SAM
GPY34_RS01335	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY34_RS01340	COG1597	lipid kinase activity
GPY34_RS01345	COG0583	DNA-binding transcription factor activity
GPY34_RS01350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY34_RS01350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY34_RS01380	COG0714	Associated with various cellular activities
GPY34_RS01385	COG0641	radical SAM
GPY34_RS01390	COG3119	arylsulfatase activity
GPY34_RS01405	COG3119	arylsulfatase activity
GPY34_RS01410	COG3119	arylsulfatase activity
GPY34_RS01415	COG0745	RESPONSE REGULATOR receiver
GPY34_RS01430	COG2205	protein histidine kinase activity
GPY34_RS01430	COG2198	Histidine kinase
GPY34_RS01430	COG0784	Response regulator, receiver
GPY34_RS01435	COG1879	ABC-type sugar transport system periplasmic component
GPY34_RS01440	COG1803	Methylglyoxal synthase
GPY34_RS01445	COG0210	DNA helicase
GPY34_RS01450	COG1289	transmembrane transporter activity
GPY34_RS01485	COG1629	transport
GPY34_RS01485	COG4771	TonB-dependent receptor
GPY34_RS01500	COG0789	Transcriptional regulator
GPY34_RS01505	COG4604	ABC transporter, ATP-binding protein
GPY34_RS01510	COG4605	iron ion homeostasis
GPY34_RS01515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY34_RS01520	COG4607	ABC-type enterochelin transport system periplasmic component
GPY34_RS01545	COG2847	Copper chaperone PCu(A)C
GPY34_RS01550	COG0443	Heat shock 70 kDa protein
GPY34_RS01585	COG0625	glutathione transferase activity
GPY34_RS01600	COG4160	amino acid transport
GPY34_RS01605	COG4215	(ABC) transporter
GPY34_RS01610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY34_RS01615	COG1126	abc transporter atp-binding protein
GPY34_RS01625	COG1902	pentaerythritol trinitrate reductase activity
GPY34_RS01630	COG0109	protoheme IX farnesyltransferase activity
GPY34_RS01635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY34_RS01640	COG1845	cytochrome c oxidase, subunit III
GPY34_RS01645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY34_RS01650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY34_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS01665	COG1024	Enoyl-CoA hydratase
GPY34_RS01670	COG1024	Enoyl-CoA hydratase
GPY34_RS01685	COG0183	Belongs to the thiolase family
GPY34_RS01695	COG1960	acyl-CoA dehydrogenase activity
GPY34_RS01700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY34_RS01705	COG1024	Enoyl-CoA hydratase
GPY34_RS01715	COG5413	integral membrane protein
GPY34_RS01730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY34_RS01740	COG5001	Diguanylate cyclase
GPY34_RS01745	COG0513	Belongs to the DEAD box helicase family
GPY34_RS01750	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY34_RS01765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY34_RS01785	COG0641	radical SAM
GPY34_RS01810	COG0840	transmembrane signaling receptor activity
GPY34_RS01815	COG1119	ATPase activity
GPY34_RS01820	COG2200	EAL domain
GPY34_RS01840	COG0513	Belongs to the DEAD box helicase family
GPY34_RS01845	COG0523	cobalamin synthesis protein
GPY34_RS01855	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY34_RS01865	COG0133	tryptophan synthase activity
GPY34_RS01870	COG4628	conserved protein (DUF2132)
GPY34_RS01875	COG0513	Belongs to the DEAD box helicase family
GPY34_RS01880	COG3530	Putative quorum-sensing-regulated virulence factor
GPY34_RS01905	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY34_RS01910	COG3186	Phenylalanine-4-hydroxylase
GPY34_RS01915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY34_RS01920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY34_RS01955	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY34_RS01960	COG1454	alcohol dehydrogenase
GPY34_RS01965	COG2133	pyrroloquinoline quinone binding
GPY34_RS01975	COG0783	Belongs to the Dps family
GPY34_RS01980	COG0840	transmembrane signaling receptor activity
GPY34_RS01990	COG0577	efflux transmembrane transporter activity
GPY34_RS01990	COG1136	(ABC) transporter
GPY34_RS02010	COG2199	diguanylate cyclase activity
GPY34_RS02025	COG3036	rescue of stalled ribosome
GPY34_RS02030	COG1278	Cold shock
GPY34_RS02065	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY34_RS02070	COG0109	protoheme IX farnesyltransferase activity
GPY34_RS02075	COG1612	heme a metabolic process
GPY34_RS02100	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY34_RS02110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY34_RS02115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY34_RS02125	COG1280	lysine exporter protein (LysE YggA)
GPY34_RS02130	COG2207	Transcriptional regulator
GPY34_RS02160	COG0697	spore germination
GPY34_RS02185	COG2814	Major facilitator Superfamily
GPY34_RS02190	COG0583	DNA-binding transcription factor activity
GPY34_RS02195	COG5001	Diguanylate cyclase
GPY34_RS02200	COG0739	heme binding
GPY34_RS02240	COG0814	amino acid
GPY34_RS02260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY34_RS02265	COG1072	(Pantothenic acid kinase))
GPY34_RS02275	COG1063	alcohol dehydrogenase
GPY34_RS02280	COG2213	PTS system mannitol-specific
GPY34_RS02285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY34_RS02305	COG0798	PFAM Bile acid sodium symporter
GPY34_RS02315	COG1881	PFAM PEBP family protein
GPY34_RS02325	COG2706	6-phosphogluconolactonase activity
GPY34_RS02340	COG1131	(ABC) transporter
GPY34_RS02345	COG0842	Transport permease protein
GPY34_RS02360	COG3383	formate dehydrogenase (NAD+) activity
GPY34_RS02385	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY34_RS02405	COG2199	diguanylate cyclase activity
GPY34_RS02405	COG2203	Gaf domain
GPY34_RS02415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY34_RS02425	COG2067	long-chain fatty acid transport protein
GPY34_RS02435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS02445	COG1505	serine-type exopeptidase activity
GPY34_RS02450	COG0488	(ABC) transporter
GPY34_RS02455	COG0589	response to stress
GPY34_RS02460	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY34_RS02480	COG0366	Alpha amylase catalytic
GPY34_RS02490	COG4934	collagen metabolic process
GPY34_RS02505	COG0583	DNA-binding transcription factor activity
GPY34_RS02515	COG0783	Belongs to the Dps family
GPY34_RS02520	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY34_RS02555	COG2814	Major facilitator Superfamily
GPY34_RS02570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY34_RS02575	COG0835	chemotaxis
GPY34_RS02575	COG0784	Response regulator, receiver
GPY34_RS02585	COG0748	coenzyme F420 binding
GPY34_RS02590	COG3721	Heme iron utilization protein
GPY34_RS02600	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY34_RS02605	COG0811	peptide transport
GPY34_RS02610	COG0848	biopolymer transport protein
GPY34_RS02620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY34_RS02625	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY34_RS02665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY34_RS02670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY34_RS02675	COG0633	Ferredoxin
GPY34_RS02675	COG0633	Ferredoxin
GPY34_RS02675	COG3217	Mosc domain protein beta barrel domain protein
GPY34_RS02675	COG3217	Mosc domain protein beta barrel domain protein
GPY34_RS02685	COG0401	homolog of Blt101
GPY34_RS02695	COG0418	dihydroorotase activity
GPY34_RS02700	COG2354	Protein conserved in bacteria
GPY34_RS02730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY34_RS02730	COG2207	Transcriptional regulator
GPY34_RS02735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY34_RS02780	COG0513	Belongs to the DEAD box helicase family
GPY34_RS02790	COG0583	DNA-binding transcription factor activity
GPY34_RS02805	COG1902	pentaerythritol trinitrate reductase activity
GPY34_RS02810	COG1063	alcohol dehydrogenase
GPY34_RS02820	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS02835	COG3122	Protein conserved in bacteria
GPY34_RS02855	COG0583	DNA-binding transcription factor activity
GPY34_RS02865	COG0252	asparaginase activity
GPY34_RS02870	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY34_RS02875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY34_RS02875	COG0574	Belongs to the PEP-utilizing enzyme family
GPY34_RS02895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY34_RS02900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY34_RS02915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS02935	COG3706	GGDEF domain
GPY34_RS02955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY34_RS02985	COG3842	ATPase activity
GPY34_RS03040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY34_RS03090	COG0583	DNA-binding transcription factor activity
GPY34_RS03100	COG4948	Mandelate Racemase Muconate Lactonizing
GPY34_RS03110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY34_RS03135	COG1342	Belongs to the UPF0251 family
GPY34_RS03145	COG3015	lipoprotein NlpE involved in copper resistance
GPY34_RS03155	COG3713	MltA-interacting MipA family protein
GPY34_RS03170	COG0583	DNA-binding transcription factor activity
GPY34_RS03195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY34_RS03205	COG1335	isochorismatase
GPY34_RS03215	COG0753	catalase activity
GPY34_RS03225	COG1349	DNA-binding transcription factor activity
GPY34_RS03230	COG0346	lactoylglutathione lyase activity
GPY34_RS03245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY34_RS03250	COG2070	2-Nitropropane dioxygenase
GPY34_RS03255	COG0737	Belongs to the 5'-nucleotidase family
GPY34_RS03265	COG1309	transcriptional regulator
GPY34_RS03285	COG1280	lysine exporter protein (LysE YggA)
GPY34_RS03300	COG0459	protein refolding
GPY34_RS03305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY34_RS03315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY34_RS03345	COG1304	FMN binding
GPY34_RS03365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS03380	COG1706	bacterial-type flagellum-dependent cell motility
GPY34_RS03385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY34_RS03390	COG4786	Flagellar basal body rod
GPY34_RS03395	COG4787	bacterial-type flagellum-dependent cell motility
GPY34_RS03400	COG1749	Flagellar hook protein flgE
GPY34_RS03405	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY34_RS03410	COG1558	bacterial-type flagellum-dependent cell motility
GPY34_RS03415	COG1815	bacterial-type flagellum-dependent cell motility
GPY34_RS03435	COG0741	lytic transglycosylase activity
GPY34_RS03445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY34_RS03465	COG1760	l-serine dehydratase
GPY34_RS03490	COG0583	DNA-binding transcription factor activity
GPY34_RS03505	COG2866	Carboxypeptidase
GPY34_RS03510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY34_RS03520	COG2990	Protein conserved in bacteria
GPY34_RS03545	COG3842	ATPase activity
GPY34_RS03555	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY34_RS03560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY34_RS03570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY34_RS03575	COG1609	Transcriptional regulator
GPY34_RS03605	COG3240	lipase activity
GPY34_RS03615	COG1136	(ABC) transporter
GPY34_RS03615	COG0577	efflux transmembrane transporter activity
GPY34_RS03620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS03625	COG2067	long-chain fatty acid transport protein
GPY34_RS03635	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY34_RS03650	COG1011	Hydrolase
GPY34_RS03690	COG0110	maltose O-acetyltransferase activity
GPY34_RS03695	COG1765	OsmC-like protein
GPY34_RS03700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY34_RS03700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY34_RS03715	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY34_RS03720	COG0415	Belongs to the DNA photolyase family
GPY34_RS03725	COG3706	GGDEF domain
GPY34_RS03740	COG0840	transmembrane signaling receptor activity
GPY34_RS03745	COG3706	GGDEF domain
GPY34_RS03750	COG3145	DNA-N1-methyladenine dioxygenase activity
GPY34_RS03760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY34_RS03780	COG3033	Beta-eliminating lyase
GPY34_RS03790	COG0579	oxidoreductase
GPY34_RS03820	COG3706	GGDEF domain
GPY34_RS03865	COG0583	DNA-binding transcription factor activity
GPY34_RS03870	COG0189	ligase activity
GPY34_RS03875	COG0189	ligase activity
GPY34_RS03875	COG4067	protein conserved in archaea
GPY34_RS03885	COG1166	arginine decarboxylase activity
GPY34_RS03890	COG0010	Belongs to the arginase family
GPY34_RS03895	COG2814	Major facilitator Superfamily
GPY34_RS03900	COG1770	oligopeptidase
GPY34_RS03915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY34_RS03920	COG1121	(ABC) transporter
GPY34_RS03925	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY34_RS03970	COG0848	biopolymer transport protein
GPY34_RS03975	COG0811	peptide transport
GPY34_RS03980	COG0811	peptide transport
GPY34_RS04000	COG0745	RESPONSE REGULATOR receiver
GPY34_RS04010	COG0584	glycerophosphoryl diester phosphodiesterase
GPY34_RS04020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY34_RS04080	COG1901	pseudouridine methyltransferase
GPY34_RS04085	COG0312	modulator of DNA gyrase
GPY34_RS04090	COG0312	modulator of DNA gyrase
GPY34_RS04100	COG0351	phosphomethylpyrimidine kinase
GPY34_RS04105	COG1116	anion transmembrane transporter activity
GPY34_RS04110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY34_RS04115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY34_RS04120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY34_RS04125	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY34_RS04130	COG0352	thiamine-phosphate diphosphorylase activity
GPY34_RS04140	COG0243	molybdopterin cofactor binding
GPY34_RS04145	COG3005	denitrification pathway
GPY34_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS04170	COG0456	acetyltransferase
GPY34_RS04170	COG0454	-acetyltransferase
GPY34_RS04190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY34_RS04195	COG1929	Belongs to the glycerate kinase type-1 family
GPY34_RS04200	COG2610	gluconate transmembrane transporter activity
GPY34_RS04205	COG3835	regulator
GPY34_RS04230	COG0546	phosphoglycolate phosphatase activity
GPY34_RS04245	COG0583	DNA-binding transcription factor activity
GPY34_RS04255	COG0583	DNA-binding transcription factor activity
GPY34_RS04265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GPY34_RS04270	COG3408	Glycogen debranching enzyme
GPY34_RS04270	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY34_RS04300	COG3047	cAMP biosynthetic process
GPY34_RS04305	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY34_RS04335	COG2375	cellular response to nickel ion
GPY34_RS04340	COG0823	Involved in the tonB-independent uptake of proteins
GPY34_RS04345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY34_RS04365	COG0800	Aldolase
GPY34_RS04370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY34_RS04385	COG1917	Cupin 2, conserved barrel domain protein
GPY34_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS04400	COG1414	Transcriptional regulator
GPY34_RS04415	COG0583	DNA-binding transcription factor activity
GPY34_RS04420	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY34_RS04425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY34_RS04440	COG2199	diguanylate cyclase activity
GPY34_RS04450	COG0561	phosphatase activity
GPY34_RS04455	COG0583	DNA-binding transcription factor activity
GPY34_RS04470	COG0564	pseudouridine synthase activity
GPY34_RS04475	COG0534	Mate efflux family protein
GPY34_RS04485	COG5001	Diguanylate cyclase
GPY34_RS04495	COG3123	guanosine phosphorylase activity
GPY34_RS04535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY34_RS04545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY34_RS04550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY34_RS04565	COG2259	Doxx family
GPY34_RS04570	COG1741	Belongs to the pirin family
GPY34_RS04590	COG0363	glucosamine-6-phosphate deaminase activity
GPY34_RS04605	COG0786	glutamate:sodium symporter activity
GPY34_RS04610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY34_RS04615	COG1131	(ABC) transporter
GPY34_RS04625	COG0786	glutamate:sodium symporter activity
GPY34_RS04660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY34_RS04670	COG3279	Response regulator of the LytR AlgR family
GPY34_RS04675	COG3275	phosphorelay sensor kinase activity
GPY34_RS04695	COG1136	(ABC) transporter
GPY34_RS04710	COG0772	Belongs to the SEDS family
GPY34_RS04715	COG0217	transcriptional regulatory protein
GPY34_RS04740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY34_RS04740	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY34_RS04750	COG0444	Belongs to the ABC transporter superfamily
GPY34_RS04755	COG4608	Belongs to the ABC transporter superfamily
GPY34_RS04780	COG1444	tRNA N-acetyltransferase activity
GPY34_RS04800	COG3340	Belongs to the peptidase S51 family
GPY34_RS04805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY34_RS04810	COG1263	PTS System
GPY34_RS04810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY34_RS04815	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY34_RS04835	COG4166	transmembrane transport
GPY34_RS04880	COG0259	pyridoxamine-phosphate oxidase activity
GPY34_RS04910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY34_RS04955	COG1132	(ABC) transporter
GPY34_RS04965	COG2207	Transcriptional regulator
GPY34_RS04990	COG0800	Aldolase
GPY34_RS04995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY34_RS05000	COG1904	glucuronate isomerase
GPY34_RS05005	COG0246	Mannitol dehydrogenase
GPY34_RS05015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY34_RS05025	COG2186	Transcriptional regulator
GPY34_RS05035	COG0513	Belongs to the DEAD box helicase family
GPY34_RS05040	COG2258	MOSC domain
GPY34_RS05055	COG1486	melibiose metabolic process
GPY34_RS05060	COG0583	DNA-binding transcription factor activity
GPY34_RS05065	COG0840	transmembrane signaling receptor activity
GPY34_RS05080	COG1595	DNA-templated transcription, initiation
GPY34_RS05110	COG3634	alkyl hydroperoxide reductase activity
GPY34_RS05115	COG0450	alkyl hydroperoxide reductase
GPY34_RS05120	COG1846	Transcriptional regulator
GPY34_RS05125	COG1764	response to oxidative stress
GPY34_RS05150	COG2160	L-arabinose isomerase activity
GPY34_RS05160	COG1069	ribulokinase activity
GPY34_RS05165	COG1879	ABC-type sugar transport system periplasmic component
GPY34_RS05170	COG1129	ABC transporter
GPY34_RS05175	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY34_RS05200	COG0745	RESPONSE REGULATOR receiver
GPY34_RS05210	COG1653	transport
GPY34_RS05215	COG0019	diaminopimelate decarboxylase activity
GPY34_RS05220	COG4264	IucA IucC family
GPY34_RS05245	COG4772	TonB-dependent receptor
GPY34_RS05250	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY34_RS05255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY34_RS05260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY34_RS05265	COG1120	ATPase activity
GPY34_RS05270	COG0840	transmembrane signaling receptor activity
GPY34_RS05275	COG0612	Peptidase, M16
GPY34_RS05285	COG0739	heme binding
GPY34_RS05310	COG4580	involved in the transport of maltose and maltodextrins
GPY34_RS05335	COG2356	endonuclease I
GPY34_RS05355	COG1982	Orn Lys Arg decarboxylase major
GPY34_RS05360	COG0531	amino acid
GPY34_RS05370	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY34_RS05380	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY34_RS05385	COG1162	GTPase activity
GPY34_RS05390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY34_RS05390	COG1263	PTS System
GPY34_RS05400	COG1999	signal sequence binding
GPY34_RS05415	COG2909	trisaccharide binding
GPY34_RS05430	COG0058	SHG alpha-glucan phosphorylase activity
GPY34_RS05435	COG1640	4-alpha-glucanotransferase
GPY34_RS05440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY34_RS05445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY34_RS05450	COG0366	Alpha amylase catalytic
GPY34_RS05465	COG3366	ferrous iron transmembrane transporter activity
GPY34_RS05470	COG0700	Nucleoside recognition
GPY34_RS05475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY34_RS05480	COG3339	Conserved Protein
GPY34_RS05485	COG1301	dicarboxylic acid transport
GPY34_RS05495	COG0583	DNA-binding transcription factor activity
GPY34_RS05510	COG0489	protein tyrosine kinase activity
GPY34_RS05510	COG3206	protein involved in exopolysaccharide biosynthesis
GPY34_RS05535	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY34_RS05540	COG3397	chitin binding
GPY34_RS05560	COG1686	Belongs to the peptidase S11 family
GPY34_RS05585	COG0583	DNA-binding transcription factor activity
GPY34_RS05590	COG4628	conserved protein (DUF2132)
GPY34_RS05600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY34_RS05610	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY34_RS05615	COG0628	permease
GPY34_RS05660	COG2814	Major facilitator Superfamily
GPY34_RS05675	COG0454	-acetyltransferase
GPY34_RS05685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY34_RS05690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY34_RS05745	COG1360	Flagellar Motor Protein
GPY34_RS05750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY34_RS05755	COG1191	sigma factor activity
GPY34_RS05760	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY34_RS05775	COG1516	flagellar protein fliS
GPY34_RS05780	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY34_RS05790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS05815	COG1987	bacterial-type flagellum assembly
GPY34_RS05840	COG2204	response regulator
GPY34_RS05855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY34_RS05895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY34_RS05915	COG0346	lactoylglutathione lyase activity
GPY34_RS05950	COG0745	RESPONSE REGULATOR receiver
GPY34_RS05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY34_RS05980	COG0156	8-amino-7-oxononanoate synthase activity
GPY34_RS05985	COG1063	alcohol dehydrogenase
GPY34_RS06020	COG0668	transmembrane transport
GPY34_RS06030	COG1304	FMN binding
GPY34_RS06035	COG1620	l-lactate permease
GPY34_RS06040	COG0583	DNA-binding transcription factor activity
GPY34_RS06045	COG1505	serine-type exopeptidase activity
GPY34_RS06050	COG4172	Belongs to the ABC transporter superfamily
GPY34_RS06060	COG1067	ATP-dependent peptidase activity
GPY34_RS06090	COG1247	-acetyltransferase
GPY34_RS06095	COG0437	4 iron, 4 sulfur cluster binding
GPY34_RS06100	COG0348	domain, Protein
GPY34_RS06115	COG1122	ATPase activity
GPY34_RS06120	COG4720	Psort location CytoplasmicMembrane, score
GPY34_RS06125	COG1566	PFAM secretion protein HlyD family protein
GPY34_RS06135	COG3706	GGDEF domain
GPY34_RS06150	COG0813	purine-nucleoside phosphorylase activity
GPY34_RS06160	COG3272	Protein of unknown function (DUF1722)
GPY34_RS06165	COG0789	Transcriptional regulator
GPY34_RS06170	COG0415	Belongs to the DNA photolyase family
GPY34_RS06175	COG1376	ErfK ybiS ycfS ynhG family protein
GPY34_RS06175	COG1388	LysM domain
GPY34_RS06185	COG0513	Belongs to the DEAD box helicase family
GPY34_RS06190	COG1770	oligopeptidase
GPY34_RS06195	COG4771	TonB-dependent receptor
GPY34_RS06220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY34_RS06225	COG0573	inorganic phosphate transmembrane transporter activity
GPY34_RS06230	COG0581	inorganic phosphate transmembrane transporter activity
GPY34_RS06235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY34_RS06250	COG2304	oxidoreductase activity
GPY34_RS06270	COG0714	Associated with various cellular activities
GPY34_RS06280	COG0840	transmembrane signaling receptor activity
GPY34_RS06290	COG2197	response regulator
GPY34_RS06340	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY34_RS06345	COG1120	ATPase activity
GPY34_RS06350	COG4774	siderophore transport
GPY34_RS06355	COG1132	(ABC) transporter
GPY34_RS06360	COG5002	protein histidine kinase activity
GPY34_RS06370	COG0569	domain protein
GPY34_RS06375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY34_RS06380	COG3300	MHYT domain
GPY34_RS06380	COG5001	Diguanylate cyclase
GPY34_RS06385	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY34_RS06390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY34_RS06405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY34_RS06405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY34_RS06405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY34_RS06410	COG2207	Transcriptional regulator
GPY34_RS06420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY34_RS06425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY34_RS06430	COG2084	Dehydrogenase
GPY34_RS06435	COG0753	catalase activity
GPY34_RS06445	COG2130	NADP-dependent
GPY34_RS06450	COG1309	transcriptional regulator
GPY34_RS06515	COG3842	ATPase activity
GPY34_RS06525	COG1175	transmembrane transport
GPY34_RS06530	COG3833	ABC-type maltose transport systems, permease component
GPY34_RS06615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY34_RS06660	COG2199	diguanylate cyclase activity
GPY34_RS06660	COG2202	Pas domain
GPY34_RS06660	COG2200	EAL domain
GPY34_RS06765	COG4789	Type iii secretion
GPY34_RS06770	COG4792	protein secretion
GPY34_RS06800	COG3710	Transcriptional regulator
GPY34_RS06815	COG4790	Type iii secretion
GPY34_RS06905	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY34_RS06925	COG2207	Transcriptional regulator
GPY34_RS06935	COG4172	Belongs to the ABC transporter superfamily
GPY34_RS06940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY34_RS06950	COG0747	negative chemotaxis
GPY34_RS06970	COG0804	urea catabolic process
GPY34_RS07050	COG0183	Belongs to the thiolase family
GPY34_RS07070	COG3746	phosphate-selective porin O and P
GPY34_RS07090	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS07115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY34_RS07125	COG0625	glutathione transferase activity
GPY34_RS07135	COG1686	Belongs to the peptidase S11 family
GPY34_RS07160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY34_RS07180	COG1278	Cold shock
GPY34_RS07185	COG1741	Belongs to the pirin family
GPY34_RS07190	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY34_RS07200	COG1846	Transcriptional regulator
GPY34_RS07225	COG0673	inositol 2-dehydrogenase activity
GPY34_RS07230	COG2194	sulfuric ester hydrolase activity
GPY34_RS07235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY34_RS07245	COG2205	protein histidine kinase activity
GPY34_RS07250	COG0745	RESPONSE REGULATOR receiver
GPY34_RS07255	COG4221	oxidoreductase activity
GPY34_RS07275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY34_RS07295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY34_RS07305	COG2814	Major facilitator Superfamily
GPY34_RS07320	COG1418	mRNA catabolic process
GPY34_RS07330	COG0402	S-adenosylhomocysteine deaminase activity
GPY34_RS07345	COG2239	Acts as a magnesium transporter
GPY34_RS07350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY34_RS07365	COG0531	amino acid
GPY34_RS07375	COG1522	sequence-specific DNA binding
GPY34_RS07400	COG2205	protein histidine kinase activity
GPY34_RS07400	COG5002	protein histidine kinase activity
GPY34_RS07400	COG0784	Response regulator, receiver
GPY34_RS07405	COG0673	inositol 2-dehydrogenase activity
GPY34_RS07410	COG0534	Mate efflux family protein
GPY34_RS07415	COG2926	Belongs to the UPF0265 family
GPY34_RS07430	COG3132	Protein of unknown function, DUF480
GPY34_RS07435	COG2827	Endonuclease containing a URI domain
GPY34_RS07440	COG1879	ABC-type sugar transport system periplasmic component
GPY34_RS07445	COG0784	Response regulator, receiver
GPY34_RS07445	COG2205	protein histidine kinase activity
GPY34_RS07455	COG1566	PFAM secretion protein HlyD family protein
GPY34_RS07475	COG1522	sequence-specific DNA binding
GPY34_RS07500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY34_RS07505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY34_RS07525	COG0183	Belongs to the thiolase family
GPY34_RS07545	COG3005	denitrification pathway
GPY34_RS07555	COG0243	molybdopterin cofactor binding
GPY34_RS07565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY34_RS07570	COG3850	Histidine kinase
GPY34_RS07575	COG2197	response regulator
GPY34_RS07590	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY34_RS07610	COG0840	transmembrane signaling receptor activity
GPY34_RS07620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY34_RS07630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY34_RS07635	COG2814	Major facilitator Superfamily
GPY34_RS07645	COG0840	transmembrane signaling receptor activity
GPY34_RS07650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY34_RS07655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY34_RS07680	COG2897	thiosulfate sulfurtransferase activity
GPY34_RS07700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY34_RS07710	COG0302	gtp cyclohydrolase
GPY34_RS07715	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY34_RS07725	COG0038	chloride channel
GPY34_RS07740	COG4989	oxidoreductase activity
GPY34_RS07755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY34_RS07755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY34_RS07760	COG0516	GMP reductase activity
GPY34_RS07765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY34_RS07835	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY34_RS07835	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY34_RS07840	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY34_RS07845	COG3474	cytochrome
GPY34_RS07855	COG0789	Transcriptional regulator
GPY34_RS07860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY34_RS07865	COG0384	phenazine biosynthesis protein PhzF
GPY34_RS07875	COG1294	oxidase, subunit
GPY34_RS07880	COG1271	oxidase subunit
GPY34_RS07885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY34_RS07890	COG0110	maltose O-acetyltransferase activity
GPY34_RS07900	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY34_RS07900	COG3264	Mechanosensitive ion channel
GPY34_RS07915	COG3850	Histidine kinase
GPY34_RS07915	COG3437	response regulator, receiver
GPY34_RS07915	COG2205	protein histidine kinase activity
GPY34_RS07915	COG4999	Histidine kinase
GPY34_RS07925	COG0439	Biotin carboxylase
GPY34_RS07935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY34_RS07940	COG1960	acyl-CoA dehydrogenase activity
GPY34_RS07950	COG0183	Belongs to the thiolase family
GPY34_RS07960	COG1960	acyl-CoA dehydrogenase activity
GPY34_RS07965	COG1024	Enoyl-CoA hydratase
GPY34_RS07990	COG3706	GGDEF domain
GPY34_RS07995	COG1309	transcriptional regulator
GPY34_RS08000	COG1012	belongs to the aldehyde dehydrogenase family
GPY34_RS08015	COG4176	ABC-type proline glycine betaine transport system permease component
GPY34_RS08020	COG0517	IMP dehydrogenase activity
GPY34_RS08020	COG4175	Glycine betaine
GPY34_RS08035	COG0330	HflC and HflK could
GPY34_RS08045	COG3300	MHYT domain
GPY34_RS08045	COG5001	Diguanylate cyclase
GPY34_RS08065	COG2205	protein histidine kinase activity
GPY34_RS08065	COG0784	Response regulator, receiver
GPY34_RS08125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY34_RS08130	COG5001	Diguanylate cyclase
GPY34_RS08135	COG1869	D-ribose catabolic process
GPY34_RS08140	COG1129	ABC transporter
GPY34_RS08145	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY34_RS08150	COG1879	ABC-type sugar transport system periplasmic component
GPY34_RS08155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY34_RS08160	COG1609	Transcriptional regulator
GPY34_RS08175	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY34_RS08195	COG0745	RESPONSE REGULATOR receiver
GPY34_RS08210	COG1785	Belongs to the alkaline phosphatase family
GPY34_RS08230	COG0745	RESPONSE REGULATOR receiver
GPY34_RS08230	COG3706	GGDEF domain
GPY34_RS08240	COG0814	amino acid
GPY34_RS08245	COG0456	acetyltransferase
GPY34_RS08250	COG0243	molybdopterin cofactor binding
GPY34_RS08255	COG1648	precorrin-2 dehydrogenase activity
GPY34_RS08255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY34_RS08275	COG3707	response regulator
GPY34_RS08285	COG1116	anion transmembrane transporter activity
GPY34_RS08285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY34_RS08290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY34_RS08295	COG1116	anion transmembrane transporter activity
GPY34_RS08300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY34_RS08300	COG2146	nitrite reductase [NAD(P)H] activity
GPY34_RS08355	COG2815	serine threonine protein kinase
GPY34_RS08355	COG0515	serine threonine protein kinase
GPY34_RS08390	COG0631	protein serine/threonine phosphatase activity
GPY34_RS08445	COG3501	Rhs element vgr protein
GPY34_RS08460	COG0420	3'-5' exonuclease activity
GPY34_RS08465	COG0419	ATPase involved in DNA repair
GPY34_RS08485	COG3040	lipid binding
GPY34_RS08495	COG2814	Major facilitator Superfamily
GPY34_RS08505	COG1288	antiporter activity
GPY34_RS08520	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY34_RS08535	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY34_RS08555	COG0583	DNA-binding transcription factor activity
GPY34_RS08560	COG0277	FAD linked oxidase domain protein
GPY34_RS08580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY34_RS08625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY34_RS08625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY34_RS08650	COG1067	ATP-dependent peptidase activity
GPY34_RS08655	COG3120	sequence-specific DNA binding
GPY34_RS08690	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY34_RS08705	COG2010	Cytochrome c
GPY34_RS08715	COG2217	Heavy metal translocating P-type atpase
GPY34_RS08730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY34_RS08735	COG0589	response to stress
GPY34_RS08745	COG0037	tRNA processing
GPY34_RS08765	COG3842	ATPase activity
GPY34_RS08770	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY34_RS08775	COG1177	transmembrane transport
GPY34_RS08780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY34_RS08785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY34_RS08790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY34_RS08800	COG0004	ammonium transporteR
GPY34_RS08840	COG0437	4 iron, 4 sulfur cluster binding
GPY34_RS08845	COG0243	molybdopterin cofactor binding
GPY34_RS08845	COG3383	formate dehydrogenase (NAD+) activity
GPY34_RS08855	COG3381	protein complex oligomerization
GPY34_RS08880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY34_RS08885	COG0488	(ABC) transporter
GPY34_RS08895	COG4191	Histidine kinase
GPY34_RS08900	COG2204	response regulator
GPY34_RS08920	COG3842	ATPase activity
GPY34_RS08925	COG0746	molybdenum cofactor guanylyltransferase activity
GPY34_RS08930	COG0303	'Molybdopterin
GPY34_RS08940	COG1940	carbohydrate kinase activity
GPY34_RS08980	COG0840	transmembrane signaling receptor activity
GPY34_RS08980	COG3290	protein histidine kinase activity
GPY34_RS08985	COG0791	NLP P60 protein
GPY34_RS08995	COG3706	GGDEF domain
GPY34_RS09000	COG2201	protein-glutamate methylesterase activity
GPY34_RS09015	COG0307	riboflavin synthase, alpha
GPY34_RS09020	COG0534	Mate efflux family protein
GPY34_RS09030	COG1793	dna ligase
GPY34_RS09065	COG2204	response regulator
GPY34_RS09075	COG0438	transferase activity, transferring glycosyl groups
GPY34_RS09110	COG0438	transferase activity, transferring glycosyl groups
GPY34_RS09115	COG1215	transferase activity, transferring glycosyl groups
GPY34_RS09120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY34_RS09130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY34_RS09145	COG1643	Atp-dependent helicase
GPY34_RS09150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY34_RS09165	COG3302	dmso reductase anchor subunit
GPY34_RS09170	COG0437	4 iron, 4 sulfur cluster binding
GPY34_RS09175	COG0243	molybdopterin cofactor binding
GPY34_RS09215	COG0443	Heat shock 70 kDa protein
GPY34_RS09220	COG0443	Heat shock 70 kDa protein
GPY34_RS09250	COG1132	(ABC) transporter
GPY34_RS09255	COG1132	(ABC) transporter
GPY34_RS09280	COG0814	amino acid
GPY34_RS09295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY34_RS09365	COG1522	sequence-specific DNA binding
GPY34_RS09400	COG0515	serine threonine protein kinase
GPY34_RS09425	COG3501	Rhs element vgr protein
GPY34_RS09445	COG2885	chlorophyll binding
GPY34_RS09465	COG0739	heme binding
GPY34_RS09475	COG0861	Integral membrane protein TerC family
GPY34_RS09485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY34_RS09490	COG1328	CTP reductase activity
GPY34_RS09495	COG1280	lysine exporter protein (LysE YggA)
GPY34_RS09505	COG5001	Diguanylate cyclase
GPY34_RS09505	COG3300	MHYT domain
GPY34_RS09515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY34_RS09515	COG4191	Histidine kinase
GPY34_RS09520	COG0471	metal ion transport
GPY34_RS09555	COG0583	DNA-binding transcription factor activity
GPY34_RS09560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY34_RS09795	COG1783	phage Terminase large subunit
GPY34_RS09840	COG0557	exoribonuclease II activity
GPY34_RS09845	COG1278	Cold shock
GPY34_RS09955	COG0625	glutathione transferase activity
GPY34_RS09965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY34_RS09975	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY34_RS09985	COG0601	transmembrane transport
GPY34_RS09990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY34_RS09995	COG0444	Belongs to the ABC transporter superfamily
GPY34_RS10015	COG3291	Pkd domain containing protein
GPY34_RS10025	COG1177	transmembrane transport
GPY34_RS10030	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY34_RS10040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY34_RS10045	COG2423	ornithine cyclodeaminase activity
GPY34_RS10065	COG3938	Belongs to the proline racemase family
GPY34_RS10095	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY34_RS10100	COG1451	nucleotide metabolic process
GPY34_RS10105	COG3475	LICD family
GPY34_RS10110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY34_RS10115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY34_RS10135	COG0583	DNA-binding transcription factor activity
GPY34_RS10155	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY34_RS10160	COG4139	cobalamin transport
GPY34_RS10165	COG2988	succinylglutamate desuccinylase activity
GPY34_RS10190	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY34_RS10195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY34_RS10200	COG0702	epimerase
GPY34_RS10210	COG2925	Exonuclease
GPY34_RS10215	COG1380	Effector of murein hydrolase LrgA
GPY34_RS10220	COG1346	cytolysis
GPY34_RS10225	COG0295	cytidine deaminase activity
GPY34_RS10230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY34_RS10235	COG0500	methyltransferase
GPY34_RS10245	COG0776	regulation of translation
GPY34_RS10260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY34_RS10260	COG0072	phenylalanine-tRNA ligase activity
GPY34_RS10265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY34_RS10270	COG3706	GGDEF domain
GPY34_RS10300	COG0393	Putative heavy-metal-binding
GPY34_RS10310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY34_RS10320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY34_RS10335	COG2188	Transcriptional regulator
GPY34_RS10340	COG1228	amidohydrolase
GPY34_RS10345	COG0010	Belongs to the arginase family
GPY34_RS10350	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY34_RS10355	COG2986	histidine ammonia-lyase
GPY34_RS10370	COG0247	lactate metabolic process
GPY34_RS10370	COG0277	FAD linked oxidase domain protein
GPY34_RS10405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY34_RS10420	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY34_RS10425	COG1643	Atp-dependent helicase
GPY34_RS10430	COG0281	malic enzyme
GPY34_RS10435	COG2949	membrane
GPY34_RS10440	COG0471	metal ion transport
GPY34_RS10445	COG3706	GGDEF domain
GPY34_RS10445	COG0745	RESPONSE REGULATOR receiver
GPY34_RS10465	COG0492	ferredoxin-NADP+ reductase activity
GPY34_RS10470	COG4988	ABC transporter
GPY34_RS10475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY34_RS10480	COG3048	D-serine ammonia-lyase activity
GPY34_RS10485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY34_RS10495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY34_RS10495	COG4191	Histidine kinase
GPY34_RS10510	COG3070	regulator of competence-specific genes
GPY34_RS10525	COG2431	L-lysine efflux transmembrane transporter activity
GPY34_RS10535	COG0076	glutamate decarboxylase activity
GPY34_RS10540	COG1737	Transcriptional regulator
GPY34_RS10555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY34_RS10560	COG3273	potassium ion transport
GPY34_RS10560	COG2985	domain, Protein
GPY34_RS10565	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY34_RS10580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY34_RS10595	COG4181	ATPase activity
GPY34_RS10600	COG0534	Mate efflux family protein
GPY34_RS10605	COG0702	epimerase
GPY34_RS10610	COG3005	denitrification pathway
GPY34_RS10640	COG2814	Major facilitator Superfamily
GPY34_RS10645	COG1187	pseudouridine synthase activity
GPY34_RS10650	COG1061	Type III restriction enzyme res subunit
GPY34_RS10660	COG0745	RESPONSE REGULATOR receiver
GPY34_RS10665	COG2205	protein histidine kinase activity
GPY34_RS10670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY34_RS10700	COG3313	Fe-S protein
GPY34_RS10725	COG0493	'glutamate synthase
GPY34_RS10735	COG0398	Pfam SNARE associated Golgi protein
GPY34_RS10740	COG4134	Bacterial extracellular solute-binding protein
GPY34_RS10745	COG4135	transport system, permease component
GPY34_RS10750	COG4136	ATPase activity
GPY34_RS10755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY34_RS10770	COG3604	Transcriptional regulator
GPY34_RS10775	COG1151	hydroxylamine reductase activity
GPY34_RS10780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY34_RS10790	COG0564	pseudouridine synthase activity
GPY34_RS10800	COG0733	neurotransmitter:sodium symporter activity
GPY34_RS10810	COG0626	cystathionine gamma-synthase activity
GPY34_RS10815	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY34_RS10820	COG5380	lipid catabolic process
GPY34_RS10825	COG2818	Glycosylase
GPY34_RS10840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS10845	COG1983	PspC domain protein
GPY34_RS10855	COG1842	Phage shock protein A
GPY34_RS10860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY34_RS10870	COG4168	peptide transport system, permease
GPY34_RS10875	COG4171	peptide transport system, permease
GPY34_RS10885	COG4172	Belongs to the ABC transporter superfamily
GPY34_RS10895	COG1227	inorganic diphosphatase activity
GPY34_RS10910	COG0243	molybdopterin cofactor binding
GPY34_RS10915	COG3005	denitrification pathway
GPY34_RS10920	COG4459	periplasmic nitrate reductase
GPY34_RS10925	COG0390	transport system, permease component
GPY34_RS10935	COG2116	formate transmembrane transporter activity
GPY34_RS10960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY34_RS10965	COG1435	thymidine kinase activity
GPY34_RS10970	COG0215	cysteine-tRNA ligase activity
GPY34_RS10975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY34_RS10980	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY34_RS10985	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY34_RS10995	COG3012	SEC-C Motif Domain Protein
GPY34_RS11000	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY34_RS11000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY34_RS11005	COG0107	imidazoleglycerol-phosphate synthase activity
GPY34_RS11010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY34_RS11015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY34_RS11020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY34_RS11020	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY34_RS11025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY34_RS11030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY34_RS11035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY34_RS11050	COG1757	Na H antiporter
GPY34_RS11060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY34_RS11070	COG0482	sulfurtransferase activity
GPY34_RS11075	COG2915	High frequency lysogenization protein hflD homolog
GPY34_RS11080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY34_RS11105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY34_RS11120	COG0300	oxidoreductase activity
GPY34_RS11130	COG0501	Belongs to the peptidase M48B family
GPY34_RS11140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY34_RS11150	COG0156	8-amino-7-oxononanoate synthase activity
GPY34_RS11155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY34_RS11160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY34_RS11165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY34_RS11175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY34_RS11180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY34_RS11185	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY34_RS11190	COG1674	ftsk spoiiie
GPY34_RS11200	COG0686	Belongs to the AlaDH PNT family
GPY34_RS11210	COG0583	DNA-binding transcription factor activity
GPY34_RS11225	COG3568	Endonuclease Exonuclease Phosphatase
GPY34_RS11255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY34_RS11260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS11275	COG0840	transmembrane signaling receptor activity
GPY34_RS11290	COG0784	Response regulator, receiver
GPY34_RS11290	COG5002	protein histidine kinase activity
GPY34_RS11300	COG0754	glutathionylspermidine amidase activity
GPY34_RS11310	COG3766	membrane
GPY34_RS11320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY34_RS11325	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY34_RS11330	COG2885	chlorophyll binding
GPY34_RS11335	COG0823	Involved in the tonB-independent uptake of proteins
GPY34_RS11350	COG0811	peptide transport
GPY34_RS11355	COG0824	Thioesterase
GPY34_RS11365	COG4890	Cyd operon protein YbgT
GPY34_RS11370	COG1294	oxidase, subunit
GPY34_RS11375	COG1271	oxidase subunit
GPY34_RS11380	COG2255	four-way junction helicase activity
GPY34_RS11385	COG0632	four-way junction helicase activity
GPY34_RS11390	COG0840	transmembrane signaling receptor activity
GPY34_RS11395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY34_RS11400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY34_RS11405	COG1801	Protein of unknown function DUF72
GPY34_RS11410	COG4106	trans-aconitate 2-methyltransferase activity
GPY34_RS11415	COG0500	methyltransferase
GPY34_RS11425	COG0189	ligase activity
GPY34_RS11425	COG4067	protein conserved in archaea
GPY34_RS11445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY34_RS11450	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY34_RS11455	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY34_RS11460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY34_RS11465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY34_RS11470	COG0745	RESPONSE REGULATOR receiver
GPY34_RS11475	COG3381	protein complex oligomerization
GPY34_RS11480	COG1609	Transcriptional regulator
GPY34_RS11485	COG3070	regulator of competence-specific genes
GPY34_RS11505	COG0297	glycogen (starch) synthase activity
GPY34_RS11510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY34_RS11515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY34_RS11525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY34_RS11535	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY34_RS11540	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY34_RS11545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY34_RS11555	COG0542	response to heat
GPY34_RS11560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY34_RS11565	COG1278	Cold shock
GPY34_RS11575	COG1187	pseudouridine synthase activity
GPY34_RS11580	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY34_RS11590	COG1199	ATP-dependent helicase activity
GPY34_RS11595	COG0730	response to heat
GPY34_RS11600	COG3923	Primosomal replication protein n
GPY34_RS11610	COG0708	Exodeoxyribonuclease III
GPY34_RS11625	COG4215	(ABC) transporter
GPY34_RS11655	COG1882	Formate acetyltransferase
GPY34_RS11665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY34_RS11675	COG3013	Belongs to the UPF0304 family
GPY34_RS11685	COG2766	serine protein kinase
GPY34_RS11690	COG2718	Belongs to the UPF0229 family
GPY34_RS11695	COG2719	SpoVR family
GPY34_RS11700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY34_RS11710	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY34_RS11715	COG1132	(ABC) transporter
GPY34_RS11720	COG0658	competence protein
GPY34_RS11720	COG2333	competence protein COMEC
GPY34_RS11730	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY34_RS11735	COG1136	(ABC) transporter
GPY34_RS11740	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY34_RS11750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY34_RS11765	COG1252	NADH dehydrogenase
GPY34_RS11775	COG3150	esterase
GPY34_RS11800	COG0537	adenosine 5'-monophosphoramidase activity
GPY34_RS11830	COG0517	IMP dehydrogenase activity
GPY34_RS11830	COG0516	GMP reductase activity
GPY34_RS11840	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY34_RS11845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY34_RS11850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY34_RS11860	COG2199	diguanylate cyclase activity
GPY34_RS11875	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY34_RS11880	COG1946	Acyl-CoA thioesterase
GPY34_RS11890	COG1522	sequence-specific DNA binding
GPY34_RS11920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY34_RS11925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS11970	COG0477	Major facilitator Superfamily
GPY34_RS11975	COG2855	membrane
GPY34_RS11995	COG1441	menaquinone biosynthetic process
GPY34_RS12000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY34_RS12005	COG0596	Alpha beta hydrolase
GPY34_RS12010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY34_RS12015	COG1169	isochorismate synthase
GPY34_RS12020	COG0436	Aminotransferase
GPY34_RS12025	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY34_RS12030	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY34_RS12045	COG1555	photosystem II stabilization
GPY34_RS12050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY34_RS12055	COG0776	regulation of translation
GPY34_RS12060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY34_RS12065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY34_RS12075	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY34_RS12085	COG2204	response regulator
GPY34_RS12095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY34_RS12100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY34_RS12105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY34_RS12110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY34_RS12130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY34_RS12135	COG0569	domain protein
GPY34_RS12140	COG0513	Belongs to the DEAD box helicase family
GPY34_RS12145	COG1253	flavin adenine dinucleotide binding
GPY34_RS12175	COG0204	Acyl-transferase
GPY34_RS12175	COG0318	PFAM AMP-dependent synthetase and ligase
GPY34_RS12180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY34_RS12185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY34_RS12200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY34_RS12205	COG1216	Glycosyl transferase, family 2
GPY34_RS12210	COG2986	histidine ammonia-lyase
GPY34_RS12235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY34_RS12240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY34_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS12250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY34_RS12265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY34_RS12270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY34_RS12275	COG0583	DNA-binding transcription factor activity
GPY34_RS12280	COG2951	lytic endotransglycosylase activity
GPY34_RS12285	COG3100	YcgL domain-containing protein
GPY34_RS12290	COG0850	regulation of cytokinetic process
GPY34_RS12295	COG2894	cell division
GPY34_RS12300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY34_RS12305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY34_RS12310	COG0318	PFAM AMP-dependent synthetase and ligase
GPY34_RS12315	COG2267	carboxylic ester hydrolase activity
GPY34_RS12330	COG1214	PFAM Peptidase M22, glycoprotease
GPY34_RS12335	COG1199	ATP-dependent helicase activity
GPY34_RS12340	COG0788	formyltetrahydrofolate deformylase activity
GPY34_RS12345	COG3102	Protein conserved in bacteria
GPY34_RS12355	COG0018	arginyl-trna synthetase
GPY34_RS12375	COG1918	ferrous iron import across plasma membrane
GPY34_RS12390	COG4977	sequence-specific DNA binding
GPY34_RS12395	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY34_RS12400	COG1121	(ABC) transporter
GPY34_RS12405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY34_RS12415	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY34_RS12420	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY34_RS12425	COG0567	Dehydrogenase, E1 component
GPY34_RS12430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY34_RS12435	COG1053	succinate dehydrogenase
GPY34_RS12440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY34_RS12445	COG2009	succinate dehydrogenase
GPY34_RS12455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY34_RS12465	COG0033	Phosphoglucomutase
GPY34_RS12470	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY34_RS12475	COG0596	Alpha beta hydrolase
GPY34_RS12485	COG0716	FMN binding
GPY34_RS12495	COG0735	belongs to the Fur family
GPY34_RS12500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY34_RS12505	COG2190	(PTS) system
GPY34_RS12505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY34_RS12505	COG1263	PTS System
GPY34_RS12515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY34_RS12520	COG1846	Transcriptional regulator
GPY34_RS12520	COG1940	carbohydrate kinase activity
GPY34_RS12525	COG4651	solute:proton antiporter activity
GPY34_RS12525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY34_RS12530	COG0367	asparagine synthase
GPY34_RS12535	COG0250	Participates in transcription elongation, termination and antitermination
GPY34_RS12540	COG3104	oligopeptide transport
GPY34_RS12545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY34_RS12550	COG0563	adenylate kinase activity
GPY34_RS12555	COG0326	Molecular chaperone. Has ATPase activity
GPY34_RS12560	COG3710	Transcriptional regulator
GPY34_RS12580	COG0622	Phosphoesterase
GPY34_RS12610	COG1090	epimerase
GPY34_RS12615	COG0300	oxidoreductase activity
GPY34_RS12625	COG3118	belongs to the thioredoxin family
GPY34_RS12630	COG0330	HflC and HflK could
GPY34_RS12655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY34_RS12660	COG3115	cell septum assembly
GPY34_RS12665	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY34_RS12670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY34_RS12680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY34_RS12685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY34_RS12690	COG2190	(PTS) system
GPY34_RS12700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS12705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS12715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS12725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS12735	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY34_RS12735	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY34_RS12740	COG1706	bacterial-type flagellum-dependent cell motility
GPY34_RS12745	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY34_RS12750	COG4786	Flagellar basal body rod
GPY34_RS12755	COG4787	bacterial-type flagellum-dependent cell motility
GPY34_RS12765	COG1749	Flagellar hook protein flgE
GPY34_RS12770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY34_RS12775	COG1558	bacterial-type flagellum-dependent cell motility
GPY34_RS12780	COG1815	bacterial-type flagellum-dependent cell motility
GPY34_RS12785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY34_RS12790	COG0784	Response regulator, receiver
GPY34_RS12790	COG0835	chemotaxis
GPY34_RS12850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY34_RS12855	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY34_RS12870	COG2608	mercury ion transmembrane transporter activity
GPY34_RS12870	COG2217	Heavy metal translocating P-type atpase
GPY34_RS12910	COG2840	Smr protein MutS2
GPY34_RS12915	COG1187	pseudouridine synthase activity
GPY34_RS12925	COG0737	Belongs to the 5'-nucleotidase family
GPY34_RS12930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY34_RS12935	COG2912	Transglutaminase-like superfamily
GPY34_RS12940	COG3094	Invasion gene expression up-regulator, SirB
GPY34_RS12945	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY34_RS12950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY34_RS12955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY34_RS12970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY34_RS12975	COG0193	aminoacyl-tRNA hydrolase activity
GPY34_RS12980	COG0012	GTP binding
GPY34_RS13095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY34_RS13105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY34_RS13110	COG1702	phosphate starvation-inducible protein PhoH
GPY34_RS13115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY34_RS13120	COG4535	Mg2 and Co2 transporter CorC
GPY34_RS13125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY34_RS13130	COG2888	peptidyl-tyrosine sulfation
GPY34_RS13135	COG0495	leucyl-tRNA aminoacylation
GPY34_RS13140	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY34_RS13145	COG1466	dna polymerase III delta subunit
GPY34_RS13150	COG0799	negative regulation of ribosome biogenesis
GPY34_RS13155	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY34_RS13160	COG0768	penicillin binding
GPY34_RS13165	COG0772	Belongs to the SEDS family
GPY34_RS13170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY34_RS13175	COG1686	Belongs to the peptidase S11 family
GPY34_RS13180	COG2921	Belongs to the UPF0250 family
GPY34_RS13185	COG0321	lipoyl(octanoyl) transferase activity
GPY34_RS13190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY34_RS13195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY34_RS13200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY34_RS13215	COG0366	Alpha amylase catalytic
GPY34_RS13220	COG1263	PTS System
GPY34_RS13220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY34_RS13230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY34_RS13240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY34_RS13245	COG2011	ABC-type metal ion transport system permease component
GPY34_RS13250	COG1464	Belongs to the NlpA lipoprotein family
GPY34_RS13255	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY34_RS13265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY34_RS13265	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY34_RS13275	COG3706	GGDEF domain
GPY34_RS13275	COG0745	RESPONSE REGULATOR receiver
GPY34_RS13280	COG1611	Belongs to the LOG family
GPY34_RS13285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY34_RS13295	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GPY34_RS13300	COG2363	Small membrane protein
GPY34_RS13310	COG0583	DNA-binding transcription factor activity
GPY34_RS13315	COG0301	tRNA thio-modification
GPY34_RS13315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY34_RS13320	COG2885	chlorophyll binding
GPY34_RS13325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY34_RS13330	COG1722	exodeoxyribonuclease VII activity
GPY34_RS13335	COG0142	geranyltranstransferase activity
GPY34_RS13340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY34_RS13345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY34_RS13350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY34_RS13355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY34_RS13375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY34_RS13375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY34_RS13380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY34_RS13385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY34_RS13390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY34_RS13405	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY34_RS13410	COG2252	PERMEase
GPY34_RS13415	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY34_RS13440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY34_RS13440	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY34_RS13450	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY34_RS13460	COG0590	tRNA wobble adenosine to inosine editing
GPY34_RS13465	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY34_RS13490	COG4969	Belongs to the N-Me-Phe pilin family
GPY34_RS13505	COG0484	heat shock protein binding
GPY34_RS13510	COG0443	Heat shock 70 kDa protein
GPY34_RS13515	COG1301	dicarboxylic acid transport
GPY34_RS13520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY34_RS13525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY34_RS13535	COG0497	DNA recombination
GPY34_RS13540	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY34_RS13545	COG2914	Belongs to the UPF0125 (RnfH) family
GPY34_RS13550	COG2867	negative regulation of translational initiation
GPY34_RS13555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY34_RS13575	COG0583	DNA-binding transcription factor activity
GPY34_RS13580	COG3153	acetyltransferase
GPY34_RS13580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY34_RS13600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY34_RS13605	COG2873	o-acetylhomoserine
GPY34_RS13640	COG1115	amino acid carrier protein
GPY34_RS13650	COG1584	GPR1 FUN34 yaaH family protein
GPY34_RS13660	COG1757	Na H antiporter
GPY34_RS13665	COG0519	Catalyzes the synthesis of GMP from XMP
GPY34_RS13665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY34_RS13670	COG0517	IMP dehydrogenase activity
GPY34_RS13670	COG0516	GMP reductase activity
GPY34_RS13675	COG1570	exodeoxyribonuclease VII activity
GPY34_RS13690	COG1160	GTP binding
GPY34_RS13695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY34_RS13700	COG2976	Protein conserved in bacteria
GPY34_RS13705	COG0124	histidyl-tRNA synthetase
GPY34_RS13710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY34_RS13725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY34_RS13730	COG0105	UTP biosynthetic process
GPY34_RS13735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY34_RS13740	COG2975	iron-sulfur cluster assembly
GPY34_RS13745	COG0633	Ferredoxin
GPY34_RS13750	COG0443	Heat shock 70 kDa protein
GPY34_RS13755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY34_RS13765	COG0822	iron-sulfur transferase activity
GPY34_RS13770	COG1104	cysteine desulfurase activity
GPY34_RS13775	COG1959	2 iron, 2 sulfur cluster binding
GPY34_RS13785	COG0483	inositol monophosphate 1-phosphatase activity
GPY34_RS13795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY34_RS13800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY34_RS13805	COG1862	Preprotein translocase
GPY34_RS13810	COG0343	queuine tRNA-ribosyltransferase activity
GPY34_RS13815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY34_RS13825	COG0517	IMP dehydrogenase activity
GPY34_RS13835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY34_RS13845	COG0583	DNA-binding transcription factor activity
GPY34_RS13850	COG0450	alkyl hydroperoxide reductase
GPY34_RS13855	COG3142	Participates in the control of copper homeostasis
GPY34_RS13865	COG0704	Plays a role in the regulation of phosphate uptake
GPY34_RS13870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY34_RS13875	COG0581	inorganic phosphate transmembrane transporter activity
GPY34_RS13885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY34_RS13890	COG0248	Ppx GppA phosphatase
GPY34_RS13900	COG5002	protein histidine kinase activity
GPY34_RS13905	COG0745	RESPONSE REGULATOR receiver
GPY34_RS13910	COG2974	May be involved in recombination
GPY34_RS13920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY34_RS13980	COG0542	response to heat
GPY34_RS13990	COG0564	pseudouridine synthase activity
GPY34_RS13995	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY34_RS14000	COG0741	lytic transglycosylase activity
GPY34_RS14005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY34_RS14010	COG1605	Chorismate mutase
GPY34_RS14010	COG0077	Prephenate dehydratase
GPY34_RS14015	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY34_RS14020	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY34_RS14030	COG0488	(ABC) transporter
GPY34_RS14045	COG0739	heme binding
GPY34_RS14050	COG1605	Chorismate mutase
GPY34_RS14050	COG0287	Prephenate dehydrogenase
GPY34_RS14055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY34_RS14060	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY34_RS14065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY34_RS14070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY34_RS14085	COG1966	Carbon starvation protein
GPY34_RS14090	COG3275	phosphorelay sensor kinase activity
GPY34_RS14095	COG3279	Response regulator of the LytR AlgR family
GPY34_RS14100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY34_RS14105	COG1047	Peptidyl-prolyl cis-trans
GPY34_RS14110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY34_RS14115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY34_RS14120	COG0196	riboflavin kinase activity
GPY34_RS14125	COG0728	peptidoglycan biosynthetic process
GPY34_RS14130	COG0268	Binds directly to 16S ribosomal RNA
GPY34_RS14140	COG0640	Transcriptional regulator
GPY34_RS14150	COG0583	DNA-binding transcription factor activity
GPY34_RS14155	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY34_RS14165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY34_RS14170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY34_RS14175	COG0730	response to heat
GPY34_RS14185	COG0494	nUDIX hydrolase
GPY34_RS14195	COG3066	DNA modification
GPY34_RS14205	COG0667	Aldo Keto reductase
GPY34_RS14220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY34_RS14230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY34_RS14235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY34_RS14245	COG0716	FMN binding
GPY34_RS14255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY34_RS14260	COG0513	Belongs to the DEAD box helicase family
GPY34_RS14265	COG3022	response to hydroperoxide
GPY34_RS14270	COG1115	amino acid carrier protein
GPY34_RS14285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY34_RS14295	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY34_RS14300	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY34_RS14305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY34_RS14310	COG0083	homoserine kinase activity
GPY34_RS14325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY34_RS14340	COG0745	RESPONSE REGULATOR receiver
GPY34_RS14350	COG2198	Histidine kinase
GPY34_RS14350	COG5002	protein histidine kinase activity
GPY34_RS14350	COG0784	Response regulator, receiver
GPY34_RS14355	COG4251	negative regulation of phosphorylation
GPY34_RS14355	COG3706	GGDEF domain
GPY34_RS14355	COG5001	Diguanylate cyclase
GPY34_RS14355	COG2203	Gaf domain
GPY34_RS14360	COG1242	4 iron, 4 sulfur cluster binding
GPY34_RS14365	COG0067	glutamate synthase
GPY34_RS14365	COG0069	glutamate synthase activity
GPY34_RS14365	COG0070	glutamate synthase
GPY34_RS14375	COG0069	glutamate synthase activity
GPY34_RS14375	COG0067	glutamate synthase
GPY34_RS14375	COG0070	glutamate synthase
GPY34_RS14380	COG0493	'glutamate synthase
GPY34_RS14390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY34_RS14400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY34_RS14405	COG2860	membrane
GPY34_RS14410	COG0583	DNA-binding transcription factor activity
GPY34_RS14415	COG0730	response to heat
GPY34_RS14425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY34_RS14430	COG0505	Belongs to the CarA family
GPY34_RS14435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY34_RS14440	COG0494	nUDIX hydrolase
GPY34_RS14445	COG0653	protein targeting
GPY34_RS14455	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY34_RS14460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY34_RS14465	COG0849	cell division
GPY34_RS14470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY34_RS14475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY34_RS14480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY34_RS14485	COG0772	Belongs to the SEDS family
GPY34_RS14490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY34_RS14495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY34_RS14500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY34_RS14505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY34_RS14510	COG0768	penicillin binding
GPY34_RS14515	COG3116	cell division
GPY34_RS14520	COG0275	rRNA processing
GPY34_RS14535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY34_RS14545	COG0792	nuclease activity
GPY34_RS14550	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY34_RS14555	COG2823	Periplasmic or secreted lipoprotein
GPY34_RS14560	COG2969	positive regulation of protein catabolic process
GPY34_RS14565	COG0625	glutathione transferase activity
GPY34_RS14570	COG2857	Cytochrome c1
GPY34_RS14575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY34_RS14580	COG0723	plastoquinol--plastocyanin reductase activity
GPY34_RS14585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY34_RS14590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY34_RS14600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY34_RS14610	COG3105	Protein conserved in bacteria
GPY34_RS14620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY34_RS14625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY34_RS14630	COG0187	DNA topoisomerase II activity
GPY34_RS14635	COG3150	esterase
GPY34_RS14645	COG3151	Protein conserved in bacteria
GPY34_RS14650	COG0494	nUDIX hydrolase
GPY34_RS14655	COG1538	Outer membrane efflux protein
GPY34_RS14660	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY34_RS14660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY34_RS14665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY34_RS14680	COG3025	triphosphatase activity
GPY34_RS14685	COG1392	Phosphate transport regulator
GPY34_RS14690	COG0306	phosphate transporter
GPY34_RS14695	COG4991	sh3 domain protein
GPY34_RS14705	COG3409	Peptidoglycan-binding domain 1 protein
GPY34_RS14705	COG3267	Type II secretory pathway component ExeA
GPY34_RS14710	COG0617	tRNA 3'-terminal CCA addition
GPY34_RS14715	COG1968	undecaprenyl-diphosphatase activity
GPY34_RS14720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY34_RS14725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY34_RS14730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY34_RS14735	COG0596	Alpha beta hydrolase
GPY34_RS14740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY34_RS14745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY34_RS14750	COG1610	YqeY-like protein
GPY34_RS14755	COG0358	DNA primase activity
GPY34_RS14760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY34_RS14770	COG1464	Belongs to the NlpA lipoprotein family
GPY34_RS14780	COG2207	Transcriptional regulator
GPY34_RS14815	COG2213	PTS system mannitol-specific
GPY34_RS14815	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY34_RS14820	COG0246	Mannitol dehydrogenase
GPY34_RS14825	COG3722	fumarate hydratase activity
GPY34_RS14840	COG1461	Dihydroxyacetone kinase
GPY34_RS14845	COG2376	Dihydroxyacetone kinase
GPY34_RS14855	COG5002	protein histidine kinase activity
GPY34_RS14870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY34_RS14875	COG1349	DNA-binding transcription factor activity
GPY34_RS14885	COG0469	pyruvate kinase activity
GPY34_RS14895	COG3706	GGDEF domain
GPY34_RS14900	COG0440	acetolactate synthase activity
GPY34_RS14905	COG0028	Belongs to the TPP enzyme family
GPY34_RS14910	COG1022	Amp-dependent synthetase and ligase
GPY34_RS14915	COG0583	DNA-binding transcription factor activity
GPY34_RS14935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY34_RS14940	COG0473	3-isopropylmalate dehydrogenase activity
GPY34_RS14945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY34_RS14950	COG0066	3-isopropylmalate dehydratase activity
GPY34_RS14960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY34_RS14965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY34_RS14970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY34_RS14975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY34_RS14980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY34_RS14985	COG2967	ApaG domain
GPY34_RS14990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY34_RS15005	COG2966	Psort location CytoplasmicMembrane, score
GPY34_RS15010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY34_RS15020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY34_RS15025	COG0142	geranyltranstransferase activity
GPY34_RS15035	COG0039	L-malate dehydrogenase activity
GPY34_RS15070	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY34_RS15075	COG1178	ABC-type Fe3 transport system permease component
GPY34_RS15080	COG4143	(ABC) transporter
GPY34_RS15085	COG0163	prenyltransferase activity
GPY34_RS15090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY34_RS15100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY34_RS15105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY34_RS15115	COG2105	PFAM AIG2 family protein
GPY34_RS15120	COG2911	Protein conserved in bacteria
GPY34_RS15125	COG0729	surface antigen
GPY34_RS15130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY34_RS15140	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY34_RS15155	COG4181	ATPase activity
GPY34_RS15175	COG0529	Catalyzes the synthesis of activated sulfate
GPY34_RS15180	COG0471	metal ion transport
GPY34_RS15180	COG3273	potassium ion transport
GPY34_RS15190	COG2895	sulfate adenylyltransferase (ATP) activity
GPY34_RS15195	COG0175	sulfate reduction
GPY34_RS15200	COG1648	precorrin-2 dehydrogenase activity
GPY34_RS15200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY34_RS15205	COG0737	Belongs to the 5'-nucleotidase family
GPY34_RS15215	COG0513	Belongs to the DEAD box helicase family
GPY34_RS15220	COG2153	protein acetylation
GPY34_RS15230	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY34_RS15240	COG0203	ribosomal protein L17
GPY34_RS15245	COG0202	RNA polymerase activity
GPY34_RS15255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY34_RS15260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY34_RS15270	COG0201	protein transport
GPY34_RS15275	COG0200	Binds to the 23S rRNA
GPY34_RS15280	COG1841	ribosomal large subunit assembly
GPY34_RS15295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY34_RS15300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY34_RS15305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY34_RS15310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY34_RS15315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY34_RS15320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY34_RS15325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY34_RS15330	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY34_RS15340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY34_RS15345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY34_RS15350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY34_RS15355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY34_RS15365	COG0088	Forms part of the polypeptide exit tunnel
GPY34_RS15370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY34_RS15380	COG0254	rRNA binding
GPY34_RS15390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY34_RS15395	COG1609	Transcriptional regulator
GPY34_RS15405	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY34_RS15410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY34_RS15415	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY34_RS15420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY34_RS15425	COG3074	FtsZ-dependent cytokinesis
GPY34_RS15435	COG1494	fructose-1,6-bisphosphatase
GPY34_RS15460	COG0149	triose-phosphate isomerase activity
GPY34_RS15465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY34_RS15485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY34_RS15500	COG1482	cell wall glycoprotein biosynthetic process
GPY34_RS15520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY34_RS15525	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPY34_RS15530	COG0438	transferase activity, transferring glycosyl groups
GPY34_RS15620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY34_RS15630	COG1560	Kdo2-lipid A biosynthetic process
GPY34_RS15640	COG0859	PFAM glycosyl transferase family 9
GPY34_RS15650	COG1519	Transferase
GPY34_RS15660	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS15710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPY34_RS15720	COG3642	lipopolysaccharide core region biosynthetic process
GPY34_RS15725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY34_RS15730	COG0859	PFAM glycosyl transferase family 9
GPY34_RS15735	COG0463	Glycosyl transferase, family 2
GPY34_RS15750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY34_RS15755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY34_RS15765	COG2194	sulfuric ester hydrolase activity
GPY34_RS15775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY34_RS15780	COG2003	Belongs to the UPF0758 family
GPY34_RS15795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY34_RS15800	COG1309	transcriptional regulator
GPY34_RS15805	COG1560	Kdo2-lipid A biosynthetic process
GPY34_RS15810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY34_RS15815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY34_RS15820	COG1561	YicC-like family, N-terminal region
GPY34_RS15840	COG2003	Belongs to the UPF0758 family
GPY34_RS15900	COG0328	RNA-DNA hybrid ribonuclease activity
GPY34_RS15945	COG4608	Belongs to the ABC transporter superfamily
GPY34_RS15950	COG0444	Belongs to the ABC transporter superfamily
GPY34_RS15955	COG0747	negative chemotaxis
GPY34_RS15960	COG4239	(ABC) transporter, permease
GPY34_RS15965	COG4174	ABC transporter (Permease)
GPY34_RS15990	COG0811	peptide transport
GPY34_RS15995	COG0848	biopolymer transport protein
GPY34_RS16010	COG0194	GDP metabolic process
GPY34_RS16015	COG1758	RNA polymerase activity
GPY34_RS16020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY34_RS16025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY34_RS16030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY34_RS16035	COG2233	PERMEase
GPY34_RS16040	COG2205	protein histidine kinase activity
GPY34_RS16045	COG0745	RESPONSE REGULATOR receiver
GPY34_RS16055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY34_RS16065	COG2183	response to ionizing radiation
GPY34_RS16075	COG0596	Alpha beta hydrolase
GPY34_RS16080	COG1040	competence protein
GPY34_RS16085	COG0316	Belongs to the HesB IscA family
GPY34_RS16085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY34_RS16090	COG0494	nUDIX hydrolase
GPY34_RS16095	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY34_RS16105	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY34_RS16110	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY34_RS16115	COG3156	type II secretion system protein K
GPY34_RS16120	COG4795	General secretion pathway protein
GPY34_RS16125	COG2165	general secretion pathway protein
GPY34_RS16130	COG2165	general secretion pathway protein
GPY34_RS16135	COG2165	general secretion pathway protein
GPY34_RS16140	COG1459	type II secretion system
GPY34_RS16145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY34_RS16155	COG3031	protein transport across the cell outer membrane
GPY34_RS16160	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY34_RS16165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY34_RS16170	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY34_RS16180	COG0456	acetyltransferase
GPY34_RS16185	COG1490	D-aminoacyl-tRNA deacylase activity
GPY34_RS16210	COG0174	glutamine synthetase
GPY34_RS16220	COG3852	Histidine kinase
GPY34_RS16225	COG2204	response regulator
GPY34_RS16235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY34_RS16240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY34_RS16270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY34_RS16280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY34_RS16280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY34_RS16305	COG0084	hydrolase, TatD family'
GPY34_RS16315	COG0805	protein transport
GPY34_RS16325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY34_RS16330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY34_RS16335	COG3165	ubiquinone biosynthetic process from chorismate
GPY34_RS16340	COG2226	methyltransferase
GPY34_RS16345	COG1322	Protein conserved in bacteria
GPY34_RS16360	COG0628	permease
GPY34_RS16410	COG2823	Periplasmic or secreted lipoprotein
GPY34_RS16420	COG2081	HI0933 family
GPY34_RS16430	COG1528	Iron-storage protein
GPY34_RS16435	COG0589	response to stress
GPY34_RS16440	COG0697	spore germination
GPY34_RS16450	COG0742	ribosomal rna small subunit methyltransferase
GPY34_RS16455	COG5001	Diguanylate cyclase
GPY34_RS16455	COG5002	protein histidine kinase activity
GPY34_RS16460	COG1522	sequence-specific DNA binding
GPY34_RS16465	COG0339	signal peptide processing
GPY34_RS16470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY34_RS16475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY34_RS16480	COG0583	DNA-binding transcription factor activity
GPY34_RS16485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY34_RS16490	COG0800	Aldolase
GPY34_RS16495	COG2610	gluconate transmembrane transporter activity
GPY34_RS16500	COG3265	gluconokinase activity
GPY34_RS16505	COG0129	dihydroxy-acid dehydratase activity
GPY34_RS16510	COG2076	Multidrug Resistance protein
GPY34_RS16520	COG0583	DNA-binding transcription factor activity
GPY34_RS16525	COG1609	Transcriptional regulator
GPY34_RS16565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY34_RS16575	COG0747	negative chemotaxis
GPY34_RS16580	COG4172	Belongs to the ABC transporter superfamily
GPY34_RS16645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS16650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY34_RS16660	COG2960	long-chain fatty acid transporting porin activity
GPY34_RS16665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY34_RS16670	COG0583	DNA-binding transcription factor activity
GPY34_RS16705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY34_RS16715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY34_RS16720	COG0408	coproporphyrinogen oxidase activity
GPY34_RS16725	COG0009	L-threonylcarbamoyladenylate synthase
GPY34_RS16730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY34_RS16735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY34_RS16740	COG0551	DNA topoisomerase type I activity
GPY34_RS16745	COG2922	Belongs to the Smg family
GPY34_RS16750	COG0758	DNA mediated transformation
GPY34_RS16760	COG0242	peptide deformylase activity
GPY34_RS16765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY34_RS16770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY34_RS16770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY34_RS16775	COG0569	domain protein
GPY34_RS16780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY34_RS16790	COG1272	protein, Hemolysin III
GPY34_RS16795	COG4326	sporulation control protein
GPY34_RS16805	COG3084	Protein conserved in bacteria
GPY34_RS16815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY34_RS16820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY34_RS16825	COG0204	Acyl-transferase
GPY34_RS16835	COG0606	chelatase, subunit chli
GPY34_RS16845	COG3978	acetolactate synthase activity
GPY34_RS16850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY34_RS16855	COG0129	dihydroxy-acid dehydratase activity
GPY34_RS16865	COG0583	DNA-binding transcription factor activity
GPY34_RS16870	COG2814	Major facilitator Superfamily
GPY34_RS16875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY34_RS16880	COG0765	amino acid transport
GPY34_RS16885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY34_RS16890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY34_RS16895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY34_RS16900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY34_RS16905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY34_RS16910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY34_RS16925	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY34_RS16930	COG3312	ion transport
GPY34_RS16935	COG1475	DNA binding
GPY34_RS16940	COG1192	Involved in chromosome partitioning
GPY34_RS16945	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY34_RS16950	COG0445	tRNA wobble uridine modification
GPY34_RS16955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY34_RS17005	COG3645	SOS response
GPY34_RS17010	COG3645	SOS response
GPY34_RS17020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY34_RS17060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY34_RS17065	COG0706	membrane insertase activity
GPY34_RS17070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY34_RS17075	COG0594	ribonuclease P activity
GPY34_RS17085	COG1126	abc transporter atp-binding protein
GPY34_RS17110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY34_RS17115	COG0592	DNA-directed DNA polymerase activity
GPY34_RS17120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY34_RS17125	COG0187	DNA topoisomerase II activity
GPY34_RS17145	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY34_RS17150	COG3977	Valine--pyruvate aminotransferase
GPY34_RS17155	COG0366	Alpha amylase catalytic
GPY34_RS17160	COG0751	glycine-tRNA ligase activity
GPY34_RS17165	COG0752	glycyl-tRNA synthetase alpha subunit
GPY34_RS17170	COG2119	membrane
GPY34_RS17180	COG0425	Belongs to the sulfur carrier protein TusA family
GPY34_RS17195	COG0604	alcohol dehydrogenase
GPY34_RS17200	COG0183	Belongs to the thiolase family
GPY34_RS17205	COG1024	Enoyl-CoA hydratase
GPY34_RS17205	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY34_RS17210	COG1739	Uncharacterized protein family UPF0029
GPY34_RS17215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY34_RS17295	COG3335	DDE superfamily endonuclease
GPY34_RS17300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY34_RS17305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY34_RS17310	COG0352	thiamine-phosphate diphosphorylase activity
GPY34_RS17315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY34_RS17320	COG2104	thiamine diphosphate biosynthetic process
GPY34_RS17325	COG2022	thiamine diphosphate biosynthetic process
GPY34_RS17335	COG0006	proline dipeptidase activity
GPY34_RS17335	COG0006	proline dipeptidase activity
GPY34_RS17365	COG3220	belongs to the UPF0276 family
GPY34_RS17375	COG0210	DNA helicase
GPY34_RS17385	COG0405	Gamma-glutamyltransferase
GPY34_RS17390	COG1280	lysine exporter protein (LysE YggA)
GPY34_RS17400	COG2962	Rard protein
GPY34_RS17405	COG0514	ATP-dependent DNA helicase (RecQ)
GPY34_RS17420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY34_RS17425	COG0248	Ppx GppA phosphatase
GPY34_RS17430	COG0513	Belongs to the DEAD box helicase family
GPY34_RS17435	COG3118	belongs to the thioredoxin family
GPY34_RS17440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY34_RS17455	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY34_RS17460	COG0633	Ferredoxin
GPY34_RS17510	COG3071	HemY protein
GPY34_RS17515	COG2959	enzyme of heme biosynthesis
GPY34_RS17520	COG1587	Uroporphyrinogen-III synthase
GPY34_RS17525	COG0181	hydroxymethylbilane synthase activity
GPY34_RS17530	COG3072	Adenylate cyclase
GPY34_RS17535	COG1965	Belongs to the frataxin family
GPY34_RS17545	COG0019	diaminopimelate decarboxylase activity
GPY34_RS17550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY34_RS17560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY34_RS17565	COG1011	Hydrolase
GPY34_RS17570	COG3287	FIST C domain
GPY34_RS17570	COG2199	diguanylate cyclase activity
GPY34_RS17570	COG2200	EAL domain
GPY34_RS17590	COG0561	phosphatase activity
GPY34_RS17595	COG2267	carboxylic ester hydrolase activity
GPY34_RS17600	COG1280	lysine exporter protein (LysE YggA)
GPY34_RS17605	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY34_RS17610	COG0640	Transcriptional regulator
GPY34_RS17615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY34_RS17670	COG2095	MarC family integral membrane protein
GPY34_RS17680	COG0742	ribosomal rna small subunit methyltransferase
GPY34_RS17685	COG0552	protein localization to endoplasmic reticulum
GPY34_RS17690	COG2884	Cell division ATP-binding protein ftsE
GPY34_RS17695	COG2177	Part of the ABC transporter FtsEX involved in
GPY34_RS17705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY34_RS17710	COG0705	Rhomboid family
GPY34_RS17715	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY34_RS17720	COG3161	chorismate lyase activity
GPY34_RS17725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY34_RS17730	COG2937	Belongs to the GPAT DAPAT family
GPY34_RS17740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY34_RS17745	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY34_RS17750	COG0534	Mate efflux family protein
GPY34_RS17755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY34_RS17770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY34_RS17775	COG4206	TonB-dependent receptor
GPY34_RS17785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY34_RS17815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY34_RS17825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY34_RS17860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY34_RS17870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY34_RS17875	COG0250	Participates in transcription elongation, termination and antitermination
GPY34_RS17880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY34_RS17885	COG0081	regulation of translation
GPY34_RS17890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY34_RS17895	COG0222	ribosome binding
GPY34_RS17900	COG0085	RNA polymerase activity
GPY34_RS17905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY34_RS17910	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY34_RS17915	COG2816	NAD+ diphosphatase activity
GPY34_RS17930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY34_RS17935	COG1573	uracil-dna glycosylase
GPY34_RS17940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY34_RS17945	COG3068	Protein conserved in bacteria
GPY34_RS17950	COG1253	flavin adenine dinucleotide binding
GPY34_RS17965	COG0151	Belongs to the GarS family
GPY34_RS17975	COG0138	bifunctional purine biosynthesis protein purh
GPY34_RS17985	COG0789	Transcriptional regulator
GPY34_RS17990	COG3710	Transcriptional regulator
GPY34_RS18000	COG0531	amino acid
GPY34_RS18005	COG1982	Orn Lys Arg decarboxylase major
GPY34_RS18070	COG3706	GGDEF domain
GPY34_RS18075	COG0488	(ABC) transporter
GPY34_RS18080	COG2814	Major facilitator Superfamily
GPY34_RS18085	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY34_RS18090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY34_RS18095	COG2264	protein methyltransferase activity
GPY34_RS18105	COG0439	Biotin carboxylase
GPY34_RS18110	COG0511	ligase activity, forming carbon-carbon bonds
GPY34_RS18115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY34_RS18120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY34_RS18135	COG2814	Major facilitator Superfamily
GPY34_RS18140	COG2205	protein histidine kinase activity
GPY34_RS18140	COG0784	Response regulator, receiver
GPY34_RS18165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY34_RS18175	COG3263	regulation of cellular component size
GPY34_RS18185	COG4232	protein-disulfide reductase activity
GPY34_RS18190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY34_RS18195	COG1027	Aspartate ammonia-lyase
GPY34_RS18200	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY34_RS18205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY34_RS18215	COG2205	protein histidine kinase activity
GPY34_RS18220	COG0745	RESPONSE REGULATOR receiver
GPY34_RS18225	COG3678	ATP-independent chaperone mediated protein folding
GPY34_RS18235	COG0205	6-phosphofructokinase activity
GPY34_RS18240	COG0534	Mate efflux family protein
GPY34_RS18245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY34_RS18250	COG0459	protein refolding
GPY34_RS18265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY34_RS18275	COG1509	lysine 2,3-aminomutase activity
GPY34_RS18280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY34_RS18290	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY34_RS18295	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY34_RS18300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY34_RS18305	COG1053	succinate dehydrogenase
GPY34_RS18315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY34_RS18335	COG4942	peptidase
GPY34_RS18340	COG1045	serine acetyltransferase
GPY34_RS18345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY34_RS18350	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY34_RS18355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY34_RS18360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY34_RS18375	COG0471	metal ion transport
GPY34_RS18380	COG0688	phosphatidylethanolamine metabolic process
GPY34_RS18385	COG1162	GTPase activity
GPY34_RS18390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY34_RS18460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY34_RS18465	COG0802	atpase or kinase
GPY34_RS18470	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY34_RS18475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY34_RS18480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY34_RS18490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY34_RS18495	COG0330	HflC and HflK could
GPY34_RS18500	COG0330	HflC and HflK could
GPY34_RS18505	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY34_RS18510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY34_RS18520	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY34_RS18525	COG1017	nitric oxide dioxygenase activity
GPY34_RS18525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY34_RS18530	COG1959	2 iron, 2 sulfur cluster binding
GPY34_RS18535	COG0557	exoribonuclease II activity
GPY34_RS18540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY34_RS18545	COG0546	phosphoglycolate phosphatase activity
GPY34_RS18550	COG0180	Tryptophanyl-tRNA synthetase
GPY34_RS18580	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY34_RS18585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY34_RS18595	COG1012	belongs to the aldehyde dehydrogenase family
GPY34_RS18605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY34_RS18610	COG3954	Phosphoribulokinase
GPY34_RS18615	COG3089	Belongs to the UPF0270 family
GPY34_RS18620	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY34_RS18630	COG0488	(ABC) transporter
GPY34_RS18640	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY34_RS18655	COG1047	Peptidyl-prolyl cis-trans
GPY34_RS18665	COG1446	asparaginase
GPY34_RS18670	COG2900	Belongs to the SlyX family
GPY34_RS18680	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY34_RS18685	COG2964	Protein conserved in bacteria
GPY34_RS18690	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY34_RS18695	COG2923	Belongs to the DsrF TusC family
GPY34_RS18700	COG2168	tRNA wobble position uridine thiolation
GPY34_RS18710	COG0049	tRNA binding
GPY34_RS18715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY34_RS18720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY34_RS18725	COG2906	2 iron, 2 sulfur cluster binding
GPY34_RS18735	COG0281	malic enzyme
GPY34_RS18745	COG0626	cystathionine gamma-synthase activity
GPY34_RS18750	COG0460	homoserine dehydrogenase
GPY34_RS18750	COG0527	aspartate kinase activity
GPY34_RS18755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY34_RS18760	COG1695	Transcriptional regulator
GPY34_RS18765	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY34_RS18770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY34_RS18775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY34_RS18780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY34_RS18785	COG0137	argininosuccinate synthase activity
GPY34_RS18790	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY34_RS18790	COG0165	Argininosuccinate lyase
GPY34_RS18805	COG0678	peroxiredoxin activity
GPY34_RS18805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY34_RS18815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY34_RS18845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY34_RS18850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY34_RS18860	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY34_RS18865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY34_RS18870	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY34_RS18875	COG2965	DNA replication, synthesis of RNA primer
GPY34_RS18885	COG0359	binds to the 23S rRNA
GPY34_RS18895	COG0305	Participates in initiation and elongation during chromosome replication
GPY34_RS18900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY34_RS18910	COG0432	Pfam Uncharacterised protein family UPF0047
GPY34_RS18915	COG0166	Belongs to the GPI family
GPY34_RS18925	COG0735	belongs to the Fur family
GPY34_RS18935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY34_RS18960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY34_RS18965	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY34_RS18970	COG0175	sulfate reduction
GPY34_RS19045	COG0646	methionine synthase
GPY34_RS19045	COG1410	methionine synthase
GPY34_RS19050	COG0527	aspartate kinase activity
GPY34_RS19055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY34_RS19065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY34_RS19080	COG0629	single-stranded DNA binding
GPY34_RS19085	COG2200	EAL domain
GPY34_RS19085	COG2199	diguanylate cyclase activity
GPY34_RS19110	COG3267	Type II secretory pathway component ExeA
GPY34_RS19110	COG3409	Peptidoglycan-binding domain 1 protein
GPY34_RS19120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY34_RS19125	COG1459	type II secretion system
GPY34_RS19170	COG1077	Cell shape determining protein MreB Mrl
GPY34_RS19175	COG1792	Involved in formation and maintenance of cell shape
GPY34_RS19180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY34_RS19185	COG0424	maF-like protein
GPY34_RS19190	COG1530	ribonuclease E activity
GPY34_RS19195	COG3164	Protein of unknown function
GPY34_RS19200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY34_RS19205	COG0312	modulator of DNA gyrase
GPY34_RS19210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY34_RS19215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY34_RS19230	COG0564	pseudouridine synthase activity
GPY34_RS19235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY34_RS19240	COG3028	Belongs to the UPF0307 family
GPY34_RS19245	COG0312	modulator of DNA gyrase
GPY34_RS19250	COG2239	Acts as a magnesium transporter
GPY34_RS19255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY34_RS19260	COG1660	Displays ATPase and GTPase activities
GPY34_RS19265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY34_RS19270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY34_RS19280	COG1137	ATPase activity
GPY34_RS19285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY34_RS19295	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY34_RS19295	COG0517	IMP dehydrogenase activity
GPY34_RS19305	COG1127	ABC transporter
GPY34_RS19310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY34_RS19315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY34_RS19320	COG2854	intermembrane phospholipid transfer
GPY34_RS19330	COG5007	Belongs to the BolA IbaG family
GPY34_RS19335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY34_RS19340	COG0204	Acyl-transferase
GPY34_RS19345	COG0251	oxidation-reduction process
GPY34_RS19350	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY34_RS19355	COG0540	Belongs to the ATCase OTCase family
GPY34_RS19365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY34_RS19370	COG2235	arginine
GPY34_RS19400	COG0525	valine-tRNA ligase activity
GPY34_RS19405	COG2927	DNA polymerase III (CHI subunit)
GPY34_RS19410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY34_RS19415	COG0795	lipopolysaccharide-transporting ATPase activity
GPY34_RS19420	COG0795	lipopolysaccharide-transporting ATPase activity
GPY34_RS19430	COG4325	translation initiation factor activity
GPY34_RS19445	COG0726	polysaccharide deacetylase
GPY34_RS19450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY34_RS19455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY34_RS19460	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY34_RS19465	COG1486	melibiose metabolic process
GPY34_RS19470	COG3394	polysaccharide catabolic process
GPY34_RS19480	COG3437	response regulator, receiver
GPY34_RS19530	COG1012	belongs to the aldehyde dehydrogenase family
GPY34_RS19600	COG0741	lytic transglycosylase activity
GPY34_RS19605	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY34_RS19615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY34_RS19625	COG2066	Belongs to the glutaminase family
GPY34_RS19630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY34_RS19635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY34_RS19645	COG1872	DUF167
GPY34_RS19650	COG0762	integral membrane protein
GPY34_RS19655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY34_RS19660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY34_RS19675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY34_RS19680	COG1678	Uncharacterized ACR, COG1678
GPY34_RS19685	COG0189	ligase activity
GPY34_RS19690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY34_RS19695	COG2356	endonuclease I
GPY34_RS19700	COG3091	SprT-like family
GPY34_RS19710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY34_RS19720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY34_RS19725	COG0583	DNA-binding transcription factor activity
GPY34_RS19730	COG4771	TonB-dependent receptor
GPY34_RS19735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY34_RS19740	COG0126	phosphoglycerate kinase activity
GPY34_RS19745	COG0191	fructose-bisphosphate aldolase activity
GPY34_RS19750	COG0668	transmembrane transport
GPY34_RS19755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY34_RS19765	COG0583	DNA-binding transcription factor activity
GPY34_RS19775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY34_RS19780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY34_RS19785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY34_RS19795	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY34_RS19805	COG3079	Belongs to the UPF0149 family
GPY34_RS19810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY34_RS19815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY34_RS19830	COG0354	folic acid binding
GPY34_RS19835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY34_RS19845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY34_RS19855	COG1595	DNA-templated transcription, initiation
GPY34_RS19860	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY34_RS19870	COG3086	response to oxidative stress
GPY34_RS19875	COG0481	GTPase activity
GPY34_RS19880	COG0681	Belongs to the peptidase S26 family
GPY34_RS19885	COG0571	ribonuclease III activity
GPY34_RS19890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY34_RS19895	COG1381	Involved in DNA repair and RecF pathway recombination
GPY34_RS19900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY34_RS19905	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY34_RS19915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY34_RS19925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY34_RS19930	COG3956	TIGRFAM MazG family protein
GPY34_RS19935	COG0504	CTP synthase activity
GPY34_RS19940	COG0148	phosphopyruvate hydratase activity
GPY34_RS19945	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY34_RS19950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY34_RS19955	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY34_RS19960	COG0585	pseudouridine synthase activity
GPY34_RS19965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY34_RS19970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY34_RS19985	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY34_RS19990	COG1546	Belongs to the CinA family
GPY34_RS19995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY34_RS20000	COG2137	regulation of response to DNA damage stimulus
GPY34_RS20005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY34_RS20010	COG0527	aspartate kinase activity
GPY34_RS20070	COG3630	sodium ion export across plasma membrane
GPY34_RS20075	COG0511	ligase activity, forming carbon-carbon bonds
GPY34_RS20075	COG5016	pyruvate
GPY34_RS20080	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY34_RS20085	COG1063	alcohol dehydrogenase
GPY34_RS20090	COG1238	metal cluster binding
GPY34_RS20095	COG0612	Peptidase, M16
GPY34_RS20100	COG2918	glutathione biosynthetic process
GPY34_RS20110	COG1854	S-ribosylhomocysteine lyase activity
GPY34_RS20115	COG4536	flavin adenine dinucleotide binding
GPY34_RS20120	COG4137	Cytochrome C assembly protein
GPY34_RS20125	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY34_RS20130	COG0228	four-way junction DNA binding
GPY34_RS20135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY34_RS20140	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY34_RS20145	COG0335	large ribosomal subunit rRNA binding
GPY34_RS20150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY34_RS20155	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY34_RS20160	COG0237	dephospho-CoA kinase activity
GPY34_RS20170	COG1459	type II secretion system
GPY34_RS20175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY34_RS20180	COG4969	Belongs to the N-Me-Phe pilin family
GPY34_RS20185	COG0157	Belongs to the NadC ModD family
GPY34_RS20195	COG2186	Transcriptional regulator
GPY34_RS20200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY34_RS20205	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY34_RS20210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY34_RS20225	COG0288	reversible hydration of carbon dioxide
GPY34_RS20230	COG0659	secondary active sulfate transmembrane transporter activity
GPY34_RS20240	COG1131	(ABC) transporter
GPY34_RS20245	COG0842	Transport permease protein
GPY34_RS20250	COG1560	Kdo2-lipid A biosynthetic process
GPY34_RS20260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY34_RS20265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY34_RS20270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY34_RS20285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY34_RS20295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY34_RS20300	COG1489	DNA binding
GPY34_RS20305	COG1643	Atp-dependent helicase
GPY34_RS20310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY34_RS20315	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY34_RS20320	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY34_RS20325	COG3112	Uncharacterised protein family (UPF0231)
GPY34_RS20335	COG0004	ammonium transporteR
GPY34_RS20340	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY34_RS20350	COG3842	ATPase activity
GPY34_RS20355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY34_RS20370	COG2971	BadF BadG BcrA BcrD
GPY34_RS20380	COG4608	Belongs to the ABC transporter superfamily
GPY34_RS20385	COG0444	Belongs to the ABC transporter superfamily
GPY34_RS20390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY34_RS20400	COG0747	negative chemotaxis
GPY34_RS20405	COG2198	Histidine kinase
GPY34_RS20405	COG0784	Response regulator, receiver
GPY34_RS20405	COG2205	protein histidine kinase activity
GPY34_RS20405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY34_RS20410	COG2813	Specifically methylates the guanine in position
GPY34_RS20415	COG0628	permease
GPY34_RS20420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY34_RS20425	COG0316	Belongs to the HesB IscA family
GPY34_RS20435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY34_RS20440	COG0739	heme binding
GPY34_RS20445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY34_RS20455	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY34_RS20460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY34_RS20465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY34_RS20470	COG1534	Rna-binding protein
GPY34_RS20475	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY34_RS20480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY34_RS20485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY34_RS20490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY34_RS20500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY34_RS20515	COG0779	Required for maturation of 30S ribosomal subunits
GPY34_RS20520	COG0195	Participates in both transcription termination and antitermination
GPY34_RS20525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY34_RS20530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY34_RS20535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY34_RS20540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY34_RS20545	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY34_RS20560	COG0534	Mate efflux family protein
GPY34_RS20585	COG3153	acetyltransferase
GPY34_RS20605	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY34_RS20615	COG0084	hydrolase, TatD family'
GPY34_RS20620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY34_RS20625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY34_RS20630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY34_RS20635	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY34_RS20640	COG0813	purine-nucleoside phosphorylase activity
GPY34_RS20650	COG0560	Phosphoserine phosphatase
GPY34_RS20660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY34_RS20665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY34_RS20670	COG0583	DNA-binding transcription factor activity
GPY34_RS20680	COG1022	Amp-dependent synthetase and ligase
GPY34_RS20685	COG2169	Transcriptional regulator
GPY34_RS20710	COG4964	Belongs to the GSP D family
GPY34_RS20770	COG0583	DNA-binding transcription factor activity
GPY34_RS20775	COG0531	amino acid
GPY34_RS20780	COG2731	YhcH YjgK YiaL family protein
GPY34_RS20785	COG3250	beta-galactosidase activity
GPY34_RS20790	COG1609	Transcriptional regulator
GPY34_RS20800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY34_RS20810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY34_RS20815	COG2017	converts alpha-aldose to the beta-anomer
GPY34_RS20830	COG2211	Major facilitator Superfamily
GPY34_RS20835	COG1609	Transcriptional regulator
GPY34_RS20840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY34_RS20855	COG0598	Magnesium transport protein CorA
GPY34_RS20860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY34_RS20865	COG1349	DNA-binding transcription factor activity
GPY34_RS20870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY34_RS20875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY34_RS20890	COG2271	Major facilitator Superfamily
GPY34_RS20895	COG0584	glycerophosphoryl diester phosphodiesterase
GPY34_RS20900	COG2171	N-acyltransferase activity
GPY34_RS20905	COG3141	response to X-ray
GPY34_RS20925	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY34_RS20930	COG1074	ATP-dependent DNA helicase activity
GPY34_RS20935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY34_RS20960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY34_RS20960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY34_RS20970	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY34_RS20975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY34_RS20980	COG2166	iron-sulfur cluster assembly
GPY34_RS20985	COG3706	GGDEF domain
GPY34_RS20990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY34_RS20995	COG0693	protein deglycase activity
GPY34_RS21000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY34_RS21025	COG1595	DNA-templated transcription, initiation
GPY34_RS21045	COG3056	Lipoprotein
GPY34_RS21050	COG2813	Specifically methylates the guanine in position
GPY34_RS21055	COG0271	Belongs to the BolA IbaG family
GPY34_RS21060	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY34_RS21065	COG1805	sodium ion transport
GPY34_RS21070	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY34_RS21075	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY34_RS21080	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY34_RS21085	COG2871	sodium ion transport
GPY34_RS21090	COG1477	protein flavinylation
GPY34_RS21105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY34_RS21110	COG0514	ATP-dependent DNA helicase (RecQ)
GPY34_RS21115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY34_RS21130	COG0733	neurotransmitter:sodium symporter activity
GPY34_RS21150	COG0442	prolyl-tRNA aminoacylation
GPY34_RS21155	COG1720	tRNA m6t6A37 methyltransferase activity
GPY34_RS21160	COG0254	rRNA binding
GPY34_RS21175	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY34_RS21180	COG1671	Belongs to the UPF0178 family
GPY34_RS21205	COG3098	single-species biofilm formation
GPY34_RS21210	COG0564	pseudouridine synthase activity
GPY34_RS21220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY34_RS21225	COG0024	Methionine aminopeptidase
GPY34_RS21230	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY34_RS21235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY34_RS21240	COG0528	UMP kinase activity
GPY34_RS21245	COG0233	cytoplasmic translational termination
GPY34_RS21250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY34_RS21255	COG0575	Belongs to the CDS family
GPY34_RS21260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY34_RS21265	COG0750	zinc metalloprotease
GPY34_RS21275	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY34_RS21280	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY34_RS21285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY34_RS21290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY34_RS21295	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY34_RS21300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY34_RS21305	COG0587	DNA-directed DNA polymerase activity
GPY34_RS21310	COG0825	malonyl-CoA metabolic process
GPY34_RS21315	COG0037	tRNA processing
GPY34_RS21325	COG0347	Belongs to the P(II) protein family
GPY34_RS21330	COG3021	interspecies interaction between organisms
GPY34_RS21340	COG0741	lytic transglycosylase activity
GPY34_RS21340	COG1388	LysM domain
GPY34_RS21345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY34_RS21350	COG2226	methyltransferase
GPY34_RS21355	COG0328	RNA-DNA hybrid ribonuclease activity
GPY34_RS21360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY34_RS21375	COG1960	acyl-CoA dehydrogenase activity
GPY34_RS21380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY34_RS21385	COG0121	glutamine amidotransferase
GPY34_RS21390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY34_RS21395	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY34_RS21400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY34_RS21405	COG2233	PERMEase
GPY34_RS21425	COG1393	Belongs to the ArsC family
GPY34_RS21430	COG4783	chaperone-mediated protein folding
GPY34_RS21445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY34_RS21450	COG2716	regulation of RNA biosynthetic process
GPY34_RS21455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY34_RS21475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY34_RS21480	COG1393	Belongs to the ArsC family
GPY34_RS21510	COG2837	iron assimilation
GPY34_RS21515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS21525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS21530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY34_RS21535	COG1334	flagellar protein FlaG
GPY34_RS21540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY34_RS21550	COG1516	flagellar protein fliS
GPY34_RS21560	COG4191	Histidine kinase
GPY34_RS21565	COG2204	response regulator
GPY34_RS21570	COG1677	Flagellar hook-basal body complex protein FliE
GPY34_RS21580	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY34_RS21630	COG1987	bacterial-type flagellum assembly
GPY34_RS21655	COG0455	bacterial-type flagellum organization
GPY34_RS21670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY34_RS21675	COG0643	Histidine kinase
GPY34_RS21675	COG2198	Histidine kinase
GPY34_RS21680	COG2201	protein-glutamate methylesterase activity
GPY34_RS21685	COG1192	Involved in chromosome partitioning
GPY34_RS21695	COG0835	chemotaxis
GPY34_RS21705	COG4133	protoheme IX ABC transporter activity
GPY34_RS21710	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY34_RS21715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY34_RS21720	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY34_RS21725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY34_RS21730	COG1138	Cytochrome C-type biogenesis protein
GPY34_RS21735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY34_RS21750	COG2853	Lipoprotein
GPY34_RS21755	COG2067	long-chain fatty acid transport protein
GPY34_RS21760	COG2067	long-chain fatty acid transport protein
GPY34_RS21775	COG0183	Belongs to the thiolase family
GPY34_RS21780	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY34_RS21780	COG1024	Enoyl-CoA hydratase
GPY34_RS21795	COG2062	phosphohistidine phosphatase, SixA
GPY34_RS21800	COG2840	Smr protein MutS2
GPY34_RS21805	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY34_RS21810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY34_RS21815	COG2860	membrane
GPY34_RS21825	COG3101	peptidyl-lysine hydroxylation
GPY34_RS21840	COG0431	NADPH-dependent FMN reductase
GPY34_RS21845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY34_RS21845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY34_RS21850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY34_RS21855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY34_RS21860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY34_RS21870	COG0101	tRNA pseudouridine synthase activity
GPY34_RS21875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY34_RS21880	COG0285	dihydrofolate synthase activity
GPY34_RS21885	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY34_RS21890	COG1286	toxin biosynthetic process
GPY34_RS21895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY34_RS21900	COG0583	DNA-binding transcription factor activity
GPY34_RS21905	COG0745	RESPONSE REGULATOR receiver
GPY34_RS21915	COG2832	Protein of unknown function (DUF454)
GPY34_RS21920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY34_RS21930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY34_RS21935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY34_RS21940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY34_RS21945	COG0814	amino acid
GPY34_RS21950	COG0251	oxidation-reduction process
GPY34_RS21955	COG3681	Belongs to the UPF0597 family
GPY34_RS21970	COG2261	transglycosylase associated protein
GPY34_RS21975	COG2983	Belongs to the UPF0260 family
GPY34_RS21980	COG0668	transmembrane transport
GPY34_RS21985	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY34_RS21990	COG0346	lactoylglutathione lyase activity
GPY34_RS22000	COG1785	Belongs to the alkaline phosphatase family
GPY34_RS22020	COG2226	methyltransferase
GPY34_RS22035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY34_RS22040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY34_RS22050	COG3139	Protein of unknown function (DUF1315)
GPY34_RS22055	COG0252	asparaginase activity
GPY34_RS22060	COG0616	signal peptide processing
GPY34_RS22065	COG1902	pentaerythritol trinitrate reductase activity
GPY34_RS22065	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY34_RS22070	COG0778	Nitroreductase
GPY34_RS22075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY34_RS22095	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY34_RS22105	COG3083	sulfuric ester hydrolase activity
GPY34_RS22110	COG3082	Protein of unknown function (DUF1414)
GPY34_RS22115	COG3081	Nucleoid-associated protein
GPY34_RS22130	COG1757	Na H antiporter
GPY34_RS22135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY34_RS22140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY34_RS22145	COG2095	MarC family integral membrane protein
GPY34_RS22150	COG1454	alcohol dehydrogenase
GPY34_RS22150	COG1012	belongs to the aldehyde dehydrogenase family
GPY34_RS22170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY34_RS22180	COG2056	Na+-H+ antiporter family
GPY34_RS22185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY34_RS22200	COG2885	chlorophyll binding
GPY34_RS22210	COG0346	lactoylglutathione lyase activity
GPY34_RS22215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY34_RS22220	COG4660	Part of a membrane complex involved in electron transport
GPY34_RS22225	COG4659	FMN binding
GPY34_RS22230	COG4658	electron transport chain
GPY34_RS22235	COG4656	Part of a membrane complex involved in electron transport
GPY34_RS22240	COG2878	Part of a membrane complex involved in electron transport
GPY34_RS22245	COG4657	Part of a membrane complex involved in electron transport
GPY34_RS22260	COG0556	nucleotide-excision repair
GPY34_RS22265	COG2204	response regulator
GPY34_RS22270	COG2198	Histidine kinase
GPY34_RS22275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY34_RS22280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY34_RS22285	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY34_RS22290	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY34_RS22295	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY34_RS22300	COG0314	molybdopterin synthase activity
GPY34_RS22310	COG0601	transmembrane transport
GPY34_RS22315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY34_RS22320	COG0444	Belongs to the ABC transporter superfamily
GPY34_RS22330	COG0435	Glutathione S-transferase
GPY34_RS22340	COG3174	membrane
GPY34_RS22345	COG0280	phosphate acetyltransferase
GPY34_RS22345	COG0857	belongs to the CobB CobQ family
GPY34_RS22350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY34_RS22355	COG3092	negative regulation of chromosome organization
GPY34_RS22365	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY34_RS22370	COG1122	ATPase activity
GPY34_RS22375	COG0366	Alpha amylase catalytic
GPY34_RS22380	COG3706	GGDEF domain
GPY34_RS22380	COG0745	RESPONSE REGULATOR receiver
GPY34_RS22385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY34_RS22390	COG0653	protein targeting
GPY34_RS22395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY34_RS22400	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY34_RS22405	COG2186	Transcriptional regulator
GPY34_RS22415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY34_RS22415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY34_RS22420	COG0489	protein tyrosine kinase activity
GPY34_RS22425	COG0572	uridine kinase
GPY34_RS22435	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY34_RS22440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY34_RS22445	COG0659	secondary active sulfate transmembrane transporter activity
GPY34_RS22450	COG1530	ribonuclease E activity
GPY34_RS22455	COG0564	pseudouridine synthase activity
GPY34_RS22460	COG0424	maF-like protein
GPY34_RS22465	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY34_RS22475	COG0416	fatty acid biosynthetic process
GPY34_RS22480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY34_RS22510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY34_RS22515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY34_RS22525	COG0084	hydrolase, TatD family'
GPY34_RS22530	COG1263	PTS System
GPY34_RS22530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY34_RS22550	COG0733	neurotransmitter:sodium symporter activity
GPY34_RS22565	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY34_RS22570	COG0469	pyruvate kinase activity
GPY34_RS22575	COG1940	carbohydrate kinase activity
GPY34_RS22580	COG0835	chemotaxis
GPY34_RS22580	COG0784	Response regulator, receiver
GPY34_RS22585	COG0587	DNA-directed DNA polymerase activity
GPY34_RS22600	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS22605	COG0616	signal peptide processing
GPY34_RS22610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY34_RS22615	COG0539	negative regulation of cytoplasmic translation
GPY34_RS22625	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY34_RS22630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY34_RS22635	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY34_RS22640	COG4166	transmembrane transport
GPY34_RS22655	COG0463	Glycosyl transferase, family 2
GPY34_RS22665	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY34_RS22675	COG3008	intermembrane lipid transfer
GPY34_RS22675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY34_RS22680	COG2995	paraquat-inducible protein a
GPY34_RS22685	COG3258	Cytochrome c
GPY34_RS22690	COG2863	cytochrome
GPY34_RS22730	COG4232	protein-disulfide reductase activity
GPY34_RS22735	COG3118	belongs to the thioredoxin family
GPY34_RS22765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS22775	COG1136	(ABC) transporter
GPY34_RS22775	COG0577	efflux transmembrane transporter activity
GPY34_RS22780	COG1136	(ABC) transporter
GPY34_RS22780	COG0577	efflux transmembrane transporter activity
GPY34_RS22785	COG1136	(ABC) transporter
GPY34_RS22785	COG0577	efflux transmembrane transporter activity
GPY34_RS22790	COG1335	isochorismatase
GPY34_RS22840	COG5002	protein histidine kinase activity
GPY34_RS22840	COG3850	Histidine kinase
GPY34_RS22845	COG0745	RESPONSE REGULATOR receiver
GPY34_RS22855	COG0840	transmembrane signaling receptor activity
GPY34_RS22860	COG1032	radical SAM domain protein
GPY34_RS22865	COG4251	negative regulation of phosphorylation
GPY34_RS22865	COG5001	Diguanylate cyclase
GPY34_RS22865	COG2203	Gaf domain
GPY34_RS22865	COG3706	GGDEF domain
GPY34_RS22880	COG0583	DNA-binding transcription factor activity
GPY34_RS22890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY34_RS22900	COG2350	Protein conserved in bacteria
GPY34_RS22905	COG1607	acyl-coa hydrolase
GPY34_RS22910	COG2917	probably involved in intracellular septation
GPY34_RS22930	COG1301	dicarboxylic acid transport
GPY34_RS22940	COG0318	PFAM AMP-dependent synthetase and ligase
GPY34_RS22945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY34_RS22950	COG0159	tryptophan synthase activity
GPY34_RS22955	COG0133	tryptophan synthase activity
GPY34_RS22960	COG0135	phosphoribosylanthranilate isomerase activity
GPY34_RS22960	COG0134	indole-3-glycerol-phosphate synthase activity
GPY34_RS22965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY34_RS22970	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY34_RS22975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY34_RS22985	COG0613	PHP domain protein
GPY34_RS22990	COG0009	L-threonylcarbamoyladenylate synthase
GPY34_RS23000	COG1187	pseudouridine synthase activity
GPY34_RS23010	COG3099	Belongs to the UPF0263 family
GPY34_RS23015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY34_RS23025	COG0417	DNA replication proofreading
GPY34_RS23030	COG2197	response regulator
GPY34_RS23035	COG0322	excinuclease ABC activity
GPY34_RS23075	COG0019	diaminopimelate decarboxylase activity
GPY34_RS23100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY34_RS23105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY34_RS23110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY34_RS23130	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY34_RS23140	COG0437	4 iron, 4 sulfur cluster binding
GPY34_RS23145	COG3301	Polysulphide reductase, NrfD
GPY34_RS23150	COG1138	Cytochrome C-type biogenesis protein
GPY34_RS23160	COG4235	cytochrome complex assembly
GPY34_RS23160	COG3088	subunit of a heme lyase
GPY34_RS23170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY34_RS23195	COG2989	Protein conserved in bacteria
GPY34_RS23200	COG3108	Peptidase M15
GPY34_RS23205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY34_RS23220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY34_RS23245	COG1846	Transcriptional regulator
GPY34_RS23250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY34_RS23255	COG0840	transmembrane signaling receptor activity
GPY34_RS23275	COG1448	Aminotransferase
GPY34_RS23300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY34_RS23310	COG0017	Asparaginyl-tRNA synthetase
GPY34_RS23320	COG0720	synthase
GPY34_RS23330	COG2200	EAL domain
GPY34_RS23335	COG1760	l-serine dehydratase
GPY34_RS23340	COG0814	amino acid
GPY34_RS23345	COG0494	nUDIX hydrolase
GPY34_RS23355	COG2205	protein histidine kinase activity
GPY34_RS23355	COG0784	Response regulator, receiver
GPY34_RS23360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY34_RS23380	COG3106	COG3106 Predicted ATPase
GPY34_RS23385	COG3768	UPF0283 membrane protein
GPY34_RS23395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY34_RS23500	COG0346	lactoylglutathione lyase activity
GPY34_RS23590	COG2026	Addiction module toxin, RelE StbE family
GPY34_RS23630	COG1051	belongs to the nudix hydrolase family
GPY34_RS23885	COG1192	Involved in chromosome partitioning
GPY34_RS23965	COG0456	acetyltransferase
GPY34_RS23980	COG0346	lactoylglutathione lyase activity
GPY34_RS24150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY34_RS24150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY34_RS24350	COG1757	Na H antiporter
GPY34_RS24355	COG0174	glutamine synthetase
GPY34_RS24365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY34_RS24370	COG1917	Cupin 2, conserved barrel domain protein
GPY34_RS24370	COG1396	sequence-specific DNA binding
GPY34_RS24375	COG1012	belongs to the aldehyde dehydrogenase family
GPY34_RS24380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY34_RS24390	COG2957	Belongs to the agmatine deiminase family
GPY34_RS24395	COG1012	belongs to the aldehyde dehydrogenase family
GPY34_RS24400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY34_RS24405	COG1227	inorganic diphosphatase activity
GPY34_RS24415	COG2200	EAL domain
GPY34_RS24415	COG2771	luxR family
GPY34_RS24425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY34_RS24440	COG1846	Transcriptional regulator
GPY34_RS24445	COG2315	Protein conserved in bacteria
GPY34_RS24465	COG0110	maltose O-acetyltransferase activity
GPY34_RS24495	COG3063	Type IV pilus biogenesis stability protein PilW
GPY34_RS24500	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY34_RS24515	COG0531	amino acid
GPY34_RS24525	COG1560	Kdo2-lipid A biosynthetic process
GPY34_RS24530	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY34_RS24535	COG1280	lysine exporter protein (LysE YggA)
GPY34_RS24545	COG1115	amino acid carrier protein
GPY34_RS24570	COG1368	sulfuric ester hydrolase activity
GPY34_RS24575	COG0642	Histidine kinase
GPY34_RS24580	COG0745	RESPONSE REGULATOR receiver
GPY34_RS24590	COG1028	Short-chain dehydrogenase reductase Sdr
GPY34_RS24600	COG1022	Amp-dependent synthetase and ligase
GPY34_RS24610	COG2113	Glycine betaine
GPY34_RS24615	COG4176	ABC-type proline glycine betaine transport system permease component
GPY34_RS24635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY34_RS24640	COG0456	acetyltransferase
GPY34_RS24645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY34_RS24650	COG0662	Cupin 2, conserved barrel domain protein
GPY34_RS24655	COG0527	aspartate kinase activity
GPY34_RS24660	COG1858	cytochrome C peroxidase
GPY34_RS24675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY34_RS24690	COG3290	protein histidine kinase activity
GPY34_RS24695	COG4565	transcriptional regulatory protein
GPY34_RS24700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY34_RS24705	COG0363	glucosamine-6-phosphate deaminase activity
GPY34_RS24710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY34_RS24730	COG3284	Transcriptional regulator
GPY34_RS24735	COG1012	belongs to the aldehyde dehydrogenase family
GPY34_RS24805	COG4669	(LipO)protein
GPY34_RS24825	COG3177	Filamentation induced by cAMP protein fic
GPY34_RS24875	COG4792	protein secretion
GPY34_RS24880	COG4791	protein targeting
GPY34_RS24885	COG4794	Type iii secretion
GPY34_RS24890	COG4790	Type iii secretion
GPY34_RS24895	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY34_RS24960	COG0457	Tetratricopeptide repeat
GPY34_RS24980	COG0730	response to heat
GPY34_RS25010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY34_RS25015	COG0372	Belongs to the citrate synthase family
GPY34_RS25025	COG2828	Protein conserved in bacteria
GPY34_RS25035	COG0456	acetyltransferase
GPY34_RS25050	COG0561	phosphatase activity
GPY34_RS25055	COG0602	queuosine metabolic process
GPY34_RS25060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY34_RS25065	COG3706	GGDEF domain
GPY34_RS25105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY34_RS25110	COG0840	transmembrane signaling receptor activity
GPY34_RS25115	COG1254	Belongs to the acylphosphatase family
GPY34_RS25120	COG2920	part of a sulfur-relay system
GPY34_RS25130	COG0670	Belongs to the BI1 family
GPY34_RS25135	COG1126	abc transporter atp-binding protein
GPY34_RS25140	COG0765	amino acid transport
GPY34_RS25145	COG4597	amino acid ABC transporter
GPY34_RS25150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY34_RS25165	COG1666	GTP binding
GPY34_RS25170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY34_RS25190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY34_RS25190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY34_RS25195	COG3008	intermembrane lipid transfer
GPY34_RS25200	COG2995	paraquat-inducible protein a
GPY34_RS25205	COG1132	(ABC) transporter
GPY34_RS25210	COG1956	GAF domain-containing protein
GPY34_RS25215	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY34_RS25230	COG0308	aminopeptidase N
GPY34_RS25240	COG2902	Dehydrogenase
GPY34_RS25245	COG0167	dihydroorotate dehydrogenase activity
GPY34_RS25260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY34_RS25260	COG0116	Belongs to the methyltransferase superfamily