locus-tag	class	description
GPY21_RS00005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY21_RS00020	COG3706	GGDEF domain
GPY21_RS00040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY21_RS00070	COG3842	ATPase activity
GPY21_RS00125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY21_RS00175	COG0583	DNA-binding transcription factor activity
GPY21_RS00185	COG4948	Mandelate Racemase Muconate Lactonizing
GPY21_RS00195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY21_RS00220	COG1342	Belongs to the UPF0251 family
GPY21_RS00230	COG3015	lipoprotein NlpE involved in copper resistance
GPY21_RS00240	COG3713	MltA-interacting MipA family protein
GPY21_RS00255	COG0583	DNA-binding transcription factor activity
GPY21_RS00280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY21_RS00290	COG1335	isochorismatase
GPY21_RS00300	COG0753	catalase activity
GPY21_RS00310	COG1349	DNA-binding transcription factor activity
GPY21_RS00315	COG0346	lactoylglutathione lyase activity
GPY21_RS00330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY21_RS00335	COG2070	2-Nitropropane dioxygenase
GPY21_RS00340	COG0737	Belongs to the 5'-nucleotidase family
GPY21_RS00350	COG1309	transcriptional regulator
GPY21_RS00370	COG1280	lysine exporter protein (LysE YggA)
GPY21_RS00385	COG0459	protein refolding
GPY21_RS00390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY21_RS00400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY21_RS00430	COG1304	FMN binding
GPY21_RS00450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS00465	COG1706	bacterial-type flagellum-dependent cell motility
GPY21_RS00470	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY21_RS00475	COG4786	Flagellar basal body rod
GPY21_RS00480	COG4787	bacterial-type flagellum-dependent cell motility
GPY21_RS00485	COG1749	Flagellar hook protein flgE
GPY21_RS00490	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY21_RS00495	COG1558	bacterial-type flagellum-dependent cell motility
GPY21_RS00500	COG1815	bacterial-type flagellum-dependent cell motility
GPY21_RS00520	COG0741	lytic transglycosylase activity
GPY21_RS00530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY21_RS00550	COG1760	l-serine dehydratase
GPY21_RS00575	COG0583	DNA-binding transcription factor activity
GPY21_RS00590	COG2866	Carboxypeptidase
GPY21_RS00595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY21_RS00605	COG2990	Protein conserved in bacteria
GPY21_RS00630	COG3842	ATPase activity
GPY21_RS00640	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY21_RS00645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY21_RS00655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY21_RS00660	COG1609	Transcriptional regulator
GPY21_RS00690	COG3240	lipase activity
GPY21_RS00700	COG1136	(ABC) transporter
GPY21_RS00700	COG0577	efflux transmembrane transporter activity
GPY21_RS00705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS00710	COG2067	long-chain fatty acid transport protein
GPY21_RS00720	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY21_RS00735	COG1011	Hydrolase
GPY21_RS00775	COG0110	maltose O-acetyltransferase activity
GPY21_RS00780	COG1765	OsmC-like protein
GPY21_RS00785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY21_RS00785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY21_RS00800	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY21_RS00805	COG0415	Belongs to the DNA photolyase family
GPY21_RS00810	COG3706	GGDEF domain
GPY21_RS00825	COG0840	transmembrane signaling receptor activity
GPY21_RS00830	COG3706	GGDEF domain
GPY21_RS00835	COG3145	DNA-N1-methyladenine dioxygenase activity
GPY21_RS00845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY21_RS00865	COG3033	Beta-eliminating lyase
GPY21_RS00875	COG0579	oxidoreductase
GPY21_RS00905	COG3706	GGDEF domain
GPY21_RS00950	COG0583	DNA-binding transcription factor activity
GPY21_RS00955	COG0189	ligase activity
GPY21_RS00960	COG4067	protein conserved in archaea
GPY21_RS00960	COG0189	ligase activity
GPY21_RS00970	COG1166	arginine decarboxylase activity
GPY21_RS00975	COG0010	Belongs to the arginase family
GPY21_RS00980	COG2814	Major facilitator Superfamily
GPY21_RS00985	COG1770	oligopeptidase
GPY21_RS01000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY21_RS01005	COG1121	(ABC) transporter
GPY21_RS01010	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY21_RS01055	COG0848	biopolymer transport protein
GPY21_RS01060	COG0811	peptide transport
GPY21_RS01065	COG0811	peptide transport
GPY21_RS01085	COG0745	RESPONSE REGULATOR receiver
GPY21_RS01095	COG0584	glycerophosphoryl diester phosphodiesterase
GPY21_RS01105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY21_RS01165	COG1901	pseudouridine methyltransferase
GPY21_RS01170	COG0312	modulator of DNA gyrase
GPY21_RS01175	COG0312	modulator of DNA gyrase
GPY21_RS01185	COG0351	phosphomethylpyrimidine kinase
GPY21_RS01190	COG1116	anion transmembrane transporter activity
GPY21_RS01195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY21_RS01200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY21_RS01205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY21_RS01210	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY21_RS01215	COG0352	thiamine-phosphate diphosphorylase activity
GPY21_RS01225	COG0243	molybdopterin cofactor binding
GPY21_RS01230	COG3005	denitrification pathway
GPY21_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS01255	COG0454	-acetyltransferase
GPY21_RS01255	COG0456	acetyltransferase
GPY21_RS01275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY21_RS01280	COG1929	Belongs to the glycerate kinase type-1 family
GPY21_RS01285	COG2610	gluconate transmembrane transporter activity
GPY21_RS01290	COG3835	regulator
GPY21_RS01315	COG0546	phosphoglycolate phosphatase activity
GPY21_RS01330	COG0583	DNA-binding transcription factor activity
GPY21_RS01340	COG0583	DNA-binding transcription factor activity
GPY21_RS01350	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GPY21_RS01355	COG3408	Glycogen debranching enzyme
GPY21_RS01355	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GPY21_RS01385	COG3047	cAMP biosynthetic process
GPY21_RS01390	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY21_RS01420	COG2375	cellular response to nickel ion
GPY21_RS01425	COG0823	Involved in the tonB-independent uptake of proteins
GPY21_RS01430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY21_RS01450	COG0800	Aldolase
GPY21_RS01455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY21_RS01470	COG1917	Cupin 2, conserved barrel domain protein
GPY21_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS01485	COG1414	Transcriptional regulator
GPY21_RS01500	COG0583	DNA-binding transcription factor activity
GPY21_RS01505	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY21_RS01510	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY21_RS01525	COG2199	diguanylate cyclase activity
GPY21_RS01535	COG0561	phosphatase activity
GPY21_RS01540	COG0583	DNA-binding transcription factor activity
GPY21_RS01555	COG0564	pseudouridine synthase activity
GPY21_RS01560	COG0534	Mate efflux family protein
GPY21_RS01570	COG5001	Diguanylate cyclase
GPY21_RS01580	COG3123	guanosine phosphorylase activity
GPY21_RS01620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY21_RS01630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY21_RS01635	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY21_RS01650	COG2259	Doxx family
GPY21_RS01655	COG1741	Belongs to the pirin family
GPY21_RS01675	COG0363	glucosamine-6-phosphate deaminase activity
GPY21_RS01690	COG0786	glutamate:sodium symporter activity
GPY21_RS01695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY21_RS01700	COG1131	(ABC) transporter
GPY21_RS01710	COG0786	glutamate:sodium symporter activity
GPY21_RS01745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY21_RS01755	COG3279	Response regulator of the LytR AlgR family
GPY21_RS01760	COG3275	phosphorelay sensor kinase activity
GPY21_RS01780	COG1136	(ABC) transporter
GPY21_RS01795	COG0772	Belongs to the SEDS family
GPY21_RS01800	COG0217	transcriptional regulatory protein
GPY21_RS01825	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY21_RS01825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY21_RS01835	COG0444	Belongs to the ABC transporter superfamily
GPY21_RS01840	COG4608	Belongs to the ABC transporter superfamily
GPY21_RS01865	COG1444	tRNA N-acetyltransferase activity
GPY21_RS01885	COG3340	Belongs to the peptidase S51 family
GPY21_RS01890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY21_RS01895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY21_RS01895	COG1263	PTS System
GPY21_RS01900	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY21_RS01920	COG4166	transmembrane transport
GPY21_RS01965	COG0259	pyridoxamine-phosphate oxidase activity
GPY21_RS01995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY21_RS02040	COG1132	(ABC) transporter
GPY21_RS02050	COG2207	Transcriptional regulator
GPY21_RS02075	COG0800	Aldolase
GPY21_RS02080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY21_RS02085	COG1904	glucuronate isomerase
GPY21_RS02090	COG0246	Mannitol dehydrogenase
GPY21_RS02100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY21_RS02110	COG2186	Transcriptional regulator
GPY21_RS02120	COG0513	Belongs to the DEAD box helicase family
GPY21_RS02125	COG2258	MOSC domain
GPY21_RS02140	COG1486	melibiose metabolic process
GPY21_RS02145	COG0583	DNA-binding transcription factor activity
GPY21_RS02150	COG0840	transmembrane signaling receptor activity
GPY21_RS02165	COG1595	DNA-templated transcription, initiation
GPY21_RS02195	COG3634	alkyl hydroperoxide reductase activity
GPY21_RS02200	COG0450	alkyl hydroperoxide reductase
GPY21_RS02205	COG1846	Transcriptional regulator
GPY21_RS02210	COG1764	response to oxidative stress
GPY21_RS02235	COG2160	L-arabinose isomerase activity
GPY21_RS02245	COG1069	ribulokinase activity
GPY21_RS02250	COG1879	ABC-type sugar transport system periplasmic component
GPY21_RS02255	COG1129	ABC transporter
GPY21_RS02260	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY21_RS02285	COG0745	RESPONSE REGULATOR receiver
GPY21_RS02295	COG1653	transport
GPY21_RS02300	COG0019	diaminopimelate decarboxylase activity
GPY21_RS02305	COG4264	IucA IucC family
GPY21_RS02330	COG4772	TonB-dependent receptor
GPY21_RS02335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY21_RS02340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY21_RS02345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY21_RS02350	COG1120	ATPase activity
GPY21_RS02355	COG0840	transmembrane signaling receptor activity
GPY21_RS02360	COG0612	Peptidase, M16
GPY21_RS02370	COG0739	heme binding
GPY21_RS02395	COG4580	involved in the transport of maltose and maltodextrins
GPY21_RS02420	COG2356	endonuclease I
GPY21_RS02440	COG1982	Orn Lys Arg decarboxylase major
GPY21_RS02445	COG0531	amino acid
GPY21_RS02455	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY21_RS02465	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY21_RS02470	COG1162	GTPase activity
GPY21_RS02475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY21_RS02475	COG1263	PTS System
GPY21_RS02485	COG1999	signal sequence binding
GPY21_RS02500	COG2909	trisaccharide binding
GPY21_RS02515	COG0058	SHG alpha-glucan phosphorylase activity
GPY21_RS02520	COG1640	4-alpha-glucanotransferase
GPY21_RS02525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY21_RS02530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY21_RS02535	COG0366	Alpha amylase catalytic
GPY21_RS02550	COG3366	ferrous iron transmembrane transporter activity
GPY21_RS02555	COG0700	Nucleoside recognition
GPY21_RS02560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY21_RS02565	COG3339	Conserved Protein
GPY21_RS02570	COG1301	dicarboxylic acid transport
GPY21_RS02580	COG0583	DNA-binding transcription factor activity
GPY21_RS02595	COG0489	protein tyrosine kinase activity
GPY21_RS02595	COG3206	protein involved in exopolysaccharide biosynthesis
GPY21_RS02615	COG2095	MarC family integral membrane protein
GPY21_RS02620	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY21_RS02625	COG3397	chitin binding
GPY21_RS02645	COG1686	Belongs to the peptidase S11 family
GPY21_RS02670	COG0583	DNA-binding transcription factor activity
GPY21_RS02675	COG4628	conserved protein (DUF2132)
GPY21_RS02685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY21_RS02695	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY21_RS02700	COG0628	permease
GPY21_RS02745	COG2814	Major facilitator Superfamily
GPY21_RS02760	COG0454	-acetyltransferase
GPY21_RS02770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY21_RS02775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY21_RS02830	COG1360	Flagellar Motor Protein
GPY21_RS02835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY21_RS02840	COG1191	sigma factor activity
GPY21_RS02845	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY21_RS02860	COG1516	flagellar protein fliS
GPY21_RS02865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY21_RS02875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS02900	COG1987	bacterial-type flagellum assembly
GPY21_RS02925	COG2204	response regulator
GPY21_RS02940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY21_RS02980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY21_RS03000	COG0346	lactoylglutathione lyase activity
GPY21_RS03035	COG0745	RESPONSE REGULATOR receiver
GPY21_RS03055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY21_RS03065	COG0156	8-amino-7-oxononanoate synthase activity
GPY21_RS03070	COG1063	alcohol dehydrogenase
GPY21_RS03105	COG0668	transmembrane transport
GPY21_RS03115	COG1304	FMN binding
GPY21_RS03120	COG1620	l-lactate permease
GPY21_RS03125	COG0583	DNA-binding transcription factor activity
GPY21_RS03130	COG1505	serine-type exopeptidase activity
GPY21_RS03135	COG4172	Belongs to the ABC transporter superfamily
GPY21_RS03145	COG1067	ATP-dependent peptidase activity
GPY21_RS03175	COG1247	-acetyltransferase
GPY21_RS03180	COG0437	4 iron, 4 sulfur cluster binding
GPY21_RS03185	COG0348	domain, Protein
GPY21_RS03200	COG1122	ATPase activity
GPY21_RS03205	COG4720	Psort location CytoplasmicMembrane, score
GPY21_RS03210	COG1566	PFAM secretion protein HlyD family protein
GPY21_RS03220	COG3706	GGDEF domain
GPY21_RS03235	COG0813	purine-nucleoside phosphorylase activity
GPY21_RS03245	COG3272	Protein of unknown function (DUF1722)
GPY21_RS03250	COG0789	Transcriptional regulator
GPY21_RS03255	COG0415	Belongs to the DNA photolyase family
GPY21_RS03260	COG1376	ErfK ybiS ycfS ynhG family protein
GPY21_RS03260	COG1388	LysM domain
GPY21_RS03270	COG0513	Belongs to the DEAD box helicase family
GPY21_RS03280	COG4771	TonB-dependent receptor
GPY21_RS03305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY21_RS03310	COG0573	inorganic phosphate transmembrane transporter activity
GPY21_RS03315	COG0581	inorganic phosphate transmembrane transporter activity
GPY21_RS03320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY21_RS03335	COG2304	oxidoreductase activity
GPY21_RS03355	COG0714	Associated with various cellular activities
GPY21_RS03365	COG0840	transmembrane signaling receptor activity
GPY21_RS03375	COG2197	response regulator
GPY21_RS03425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY21_RS03430	COG1120	ATPase activity
GPY21_RS03435	COG4774	siderophore transport
GPY21_RS03440	COG1132	(ABC) transporter
GPY21_RS03445	COG5002	protein histidine kinase activity
GPY21_RS03455	COG0569	domain protein
GPY21_RS03460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY21_RS03465	COG5001	Diguanylate cyclase
GPY21_RS03465	COG3300	MHYT domain
GPY21_RS03470	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY21_RS03475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY21_RS03490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY21_RS03490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY21_RS03490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY21_RS03495	COG2207	Transcriptional regulator
GPY21_RS03505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY21_RS03510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY21_RS03515	COG2084	Dehydrogenase
GPY21_RS03520	COG0753	catalase activity
GPY21_RS03530	COG2130	NADP-dependent
GPY21_RS03535	COG1309	transcriptional regulator
GPY21_RS03600	COG3842	ATPase activity
GPY21_RS03610	COG1175	transmembrane transport
GPY21_RS03615	COG3833	ABC-type maltose transport systems, permease component
GPY21_RS03705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY21_RS03750	COG2199	diguanylate cyclase activity
GPY21_RS03750	COG2200	EAL domain
GPY21_RS03750	COG2202	Pas domain
GPY21_RS03860	COG4789	Type iii secretion
GPY21_RS03865	COG4792	protein secretion
GPY21_RS03895	COG3710	Transcriptional regulator
GPY21_RS03910	COG4790	Type iii secretion
GPY21_RS04005	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY21_RS04025	COG2207	Transcriptional regulator
GPY21_RS04035	COG4172	Belongs to the ABC transporter superfamily
GPY21_RS04040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY21_RS04050	COG0747	negative chemotaxis
GPY21_RS04070	COG0804	urea catabolic process
GPY21_RS04150	COG0183	Belongs to the thiolase family
GPY21_RS04170	COG3746	phosphate-selective porin O and P
GPY21_RS04190	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS04215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY21_RS04225	COG0625	glutathione transferase activity
GPY21_RS04235	COG1686	Belongs to the peptidase S11 family
GPY21_RS04260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY21_RS04275	COG1278	Cold shock
GPY21_RS04280	COG1741	Belongs to the pirin family
GPY21_RS04285	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY21_RS04295	COG1846	Transcriptional regulator
GPY21_RS04320	COG0673	inositol 2-dehydrogenase activity
GPY21_RS04325	COG2194	sulfuric ester hydrolase activity
GPY21_RS04330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY21_RS04340	COG2205	protein histidine kinase activity
GPY21_RS04345	COG0745	RESPONSE REGULATOR receiver
GPY21_RS04350	COG4221	oxidoreductase activity
GPY21_RS04370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY21_RS04390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY21_RS04400	COG2814	Major facilitator Superfamily
GPY21_RS04415	COG1418	mRNA catabolic process
GPY21_RS04425	COG0402	S-adenosylhomocysteine deaminase activity
GPY21_RS04430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY21_RS04440	COG2239	Acts as a magnesium transporter
GPY21_RS04445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY21_RS04460	COG0531	amino acid
GPY21_RS04470	COG1522	sequence-specific DNA binding
GPY21_RS04495	COG5002	protein histidine kinase activity
GPY21_RS04495	COG2205	protein histidine kinase activity
GPY21_RS04495	COG0784	Response regulator, receiver
GPY21_RS04500	COG0673	inositol 2-dehydrogenase activity
GPY21_RS04505	COG0534	Mate efflux family protein
GPY21_RS04510	COG2926	Belongs to the UPF0265 family
GPY21_RS04530	COG2827	Endonuclease containing a URI domain
GPY21_RS04535	COG1879	ABC-type sugar transport system periplasmic component
GPY21_RS04540	COG0784	Response regulator, receiver
GPY21_RS04540	COG2205	protein histidine kinase activity
GPY21_RS04550	COG1566	PFAM secretion protein HlyD family protein
GPY21_RS04570	COG1522	sequence-specific DNA binding
GPY21_RS04595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY21_RS04600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY21_RS04620	COG0183	Belongs to the thiolase family
GPY21_RS04640	COG3005	denitrification pathway
GPY21_RS04650	COG0243	molybdopterin cofactor binding
GPY21_RS04660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY21_RS04665	COG3850	Histidine kinase
GPY21_RS04670	COG2197	response regulator
GPY21_RS04685	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY21_RS04705	COG0840	transmembrane signaling receptor activity
GPY21_RS04715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY21_RS04725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY21_RS04730	COG2814	Major facilitator Superfamily
GPY21_RS04740	COG0840	transmembrane signaling receptor activity
GPY21_RS04745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY21_RS04750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY21_RS04775	COG2897	thiosulfate sulfurtransferase activity
GPY21_RS04795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY21_RS04805	COG0302	gtp cyclohydrolase
GPY21_RS04810	COG1914	H( )-stimulated, divalent metal cation uptake system
GPY21_RS04820	COG0038	chloride channel
GPY21_RS04835	COG4989	oxidoreductase activity
GPY21_RS04850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY21_RS04850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY21_RS04855	COG0516	GMP reductase activity
GPY21_RS04860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY21_RS04930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY21_RS04930	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY21_RS04935	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY21_RS04940	COG3474	cytochrome
GPY21_RS04950	COG0789	Transcriptional regulator
GPY21_RS04955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY21_RS04960	COG0384	phenazine biosynthesis protein PhzF
GPY21_RS04970	COG1294	oxidase, subunit
GPY21_RS04975	COG1271	oxidase subunit
GPY21_RS04980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY21_RS04985	COG0110	maltose O-acetyltransferase activity
GPY21_RS04995	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY21_RS04995	COG3264	Mechanosensitive ion channel
GPY21_RS05010	COG3850	Histidine kinase
GPY21_RS05010	COG3437	response regulator, receiver
GPY21_RS05010	COG2205	protein histidine kinase activity
GPY21_RS05010	COG4999	Histidine kinase
GPY21_RS05020	COG0439	Biotin carboxylase
GPY21_RS05030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY21_RS05035	COG1960	acyl-CoA dehydrogenase activity
GPY21_RS05045	COG0183	Belongs to the thiolase family
GPY21_RS05055	COG1960	acyl-CoA dehydrogenase activity
GPY21_RS05060	COG1024	Enoyl-CoA hydratase
GPY21_RS05085	COG3706	GGDEF domain
GPY21_RS05090	COG1309	transcriptional regulator
GPY21_RS05095	COG1012	belongs to the aldehyde dehydrogenase family
GPY21_RS05110	COG4176	ABC-type proline glycine betaine transport system permease component
GPY21_RS05115	COG0517	IMP dehydrogenase activity
GPY21_RS05115	COG4175	Glycine betaine
GPY21_RS05130	COG0330	HflC and HflK could
GPY21_RS05140	COG3300	MHYT domain
GPY21_RS05140	COG5001	Diguanylate cyclase
GPY21_RS05160	COG2205	protein histidine kinase activity
GPY21_RS05160	COG0784	Response regulator, receiver
GPY21_RS05220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY21_RS05225	COG5001	Diguanylate cyclase
GPY21_RS05230	COG1869	D-ribose catabolic process
GPY21_RS05235	COG1129	ABC transporter
GPY21_RS05240	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY21_RS05245	COG1879	ABC-type sugar transport system periplasmic component
GPY21_RS05250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY21_RS05255	COG1609	Transcriptional regulator
GPY21_RS05270	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY21_RS05290	COG0745	RESPONSE REGULATOR receiver
GPY21_RS05305	COG1785	Belongs to the alkaline phosphatase family
GPY21_RS05325	COG3706	GGDEF domain
GPY21_RS05325	COG0745	RESPONSE REGULATOR receiver
GPY21_RS05335	COG0814	amino acid
GPY21_RS05340	COG0456	acetyltransferase
GPY21_RS05345	COG0243	molybdopterin cofactor binding
GPY21_RS05350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY21_RS05350	COG1648	precorrin-2 dehydrogenase activity
GPY21_RS05370	COG3707	response regulator
GPY21_RS05380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY21_RS05380	COG1116	anion transmembrane transporter activity
GPY21_RS05385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY21_RS05390	COG1116	anion transmembrane transporter activity
GPY21_RS05395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY21_RS05395	COG2146	nitrite reductase [NAD(P)H] activity
GPY21_RS05450	COG0515	serine threonine protein kinase
GPY21_RS05450	COG2815	serine threonine protein kinase
GPY21_RS05485	COG0631	protein serine/threonine phosphatase activity
GPY21_RS05540	COG3501	Rhs element vgr protein
GPY21_RS05555	COG0420	3'-5' exonuclease activity
GPY21_RS05560	COG0419	ATPase involved in DNA repair
GPY21_RS05580	COG3040	lipid binding
GPY21_RS05590	COG2814	Major facilitator Superfamily
GPY21_RS05600	COG1288	antiporter activity
GPY21_RS05615	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY21_RS05630	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY21_RS05650	COG0583	DNA-binding transcription factor activity
GPY21_RS05655	COG0277	FAD linked oxidase domain protein
GPY21_RS05675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY21_RS05720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY21_RS05720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY21_RS05760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY21_RS05765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY21_RS05770	COG2146	nitrite reductase [NAD(P)H] activity
GPY21_RS05775	COG2116	formate transmembrane transporter activity
GPY21_RS05795	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY21_RS05825	COG0534	Mate efflux family protein
GPY21_RS05835	COG2814	Major facilitator Superfamily
GPY21_RS05840	COG3118	belongs to the thioredoxin family
GPY21_RS05845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY21_RS05870	COG2271	Major facilitator Superfamily
GPY21_RS05875	COG3851	Histidine kinase
GPY21_RS05880	COG2197	response regulator
GPY21_RS05890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY21_RS05895	COG0583	DNA-binding transcription factor activity
GPY21_RS05905	COG0243	molybdopterin cofactor binding
GPY21_RS05935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY21_RS05950	COG1328	CTP reductase activity
GPY21_RS05955	COG0602	queuosine metabolic process
GPY21_RS05960	COG0534	Mate efflux family protein
GPY21_RS05980	COG4067	protein conserved in archaea
GPY21_RS05980	COG0189	ligase activity
GPY21_RS05990	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY21_RS05995	COG1492	cobalamin metabolic process
GPY21_RS06000	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY21_RS06005	COG4149	molybdate abc transporter
GPY21_RS06010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY21_RS06020	COG3706	GGDEF domain
GPY21_RS06020	COG2203	Gaf domain
GPY21_RS06020	COG5001	Diguanylate cyclase
GPY21_RS06020	COG4251	negative regulation of phosphorylation
GPY21_RS06030	COG3706	GGDEF domain
GPY21_RS06030	COG0745	RESPONSE REGULATOR receiver
GPY21_RS06045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY21_RS06050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY21_RS06075	COG3140	Belongs to the UPF0181 family
GPY21_RS06080	COG0589	response to stress
GPY21_RS06095	COG0023	Translation Initiation Factor
GPY21_RS06105	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY21_RS06115	COG1042	CoA-binding domain protein
GPY21_RS06115	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY21_RS06115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY21_RS06120	COG0583	DNA-binding transcription factor activity
GPY21_RS06125	COG1629	transport
GPY21_RS06125	COG4771	TonB-dependent receptor
GPY21_RS06135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY21_RS06140	COG3447	MASE1 domain protein
GPY21_RS06140	COG5001	Diguanylate cyclase
GPY21_RS06140	COG5002	protein histidine kinase activity
GPY21_RS06145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY21_RS06150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY21_RS06155	COG1984	allophanate hydrolase subunit 2
GPY21_RS06165	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY21_RS06170	COG4181	ATPase activity
GPY21_RS06180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY21_RS06185	COG3300	MHYT domain
GPY21_RS06185	COG5001	Diguanylate cyclase
GPY21_RS06195	COG0484	heat shock protein binding
GPY21_RS06220	COG4533	DNA binding
GPY21_RS06230	COG2050	protein possibly involved in aromatic compounds catabolism
GPY21_RS06245	COG2067	long-chain fatty acid transport protein
GPY21_RS06250	COG2267	carboxylic ester hydrolase activity
GPY21_RS06255	COG1943	Transposase
GPY21_RS06270	COG0861	Integral membrane protein TerC family
GPY21_RS06275	COG0737	Belongs to the 5'-nucleotidase family
GPY21_RS06280	COG3593	DNA synthesis involved in DNA repair
GPY21_RS06290	COG0583	DNA-binding transcription factor activity
GPY21_RS06295	COG2116	formate transmembrane transporter activity
GPY21_RS06300	COG2353	YceI-like domain
GPY21_RS06305	COG3038	cytochrome b561
GPY21_RS06320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY21_RS06325	COG0513	Belongs to the DEAD box helicase family
GPY21_RS06330	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY21_RS06340	COG0840	transmembrane signaling receptor activity
GPY21_RS06345	COG0546	phosphoglycolate phosphatase activity
GPY21_RS06355	COG0784	Response regulator, receiver
GPY21_RS06355	COG3437	response regulator, receiver
GPY21_RS06375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY21_RS06380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY21_RS06385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY21_RS06400	COG2207	Transcriptional regulator
GPY21_RS06405	COG1979	alcohol dehydrogenase
GPY21_RS06425	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY21_RS06430	COG2271	Major facilitator Superfamily
GPY21_RS06435	COG0469	pyruvate kinase activity
GPY21_RS06440	COG1126	abc transporter atp-binding protein
GPY21_RS06445	COG0765	amino acid transport
GPY21_RS06450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY21_RS06455	COG0765	amino acid transport
GPY21_RS06460	COG2203	Gaf domain
GPY21_RS06460	COG2200	EAL domain
GPY21_RS06460	COG2199	diguanylate cyclase activity
GPY21_RS06480	COG1609	Transcriptional regulator
GPY21_RS06485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY21_RS06485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY21_RS06490	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY21_RS06495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY21_RS06495	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY21_RS06495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY21_RS06535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY21_RS06540	COG0509	glycine decarboxylation via glycine cleavage system
GPY21_RS06545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY21_RS06545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY21_RS06560	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY21_RS06565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY21_RS06570	COG0583	DNA-binding transcription factor activity
GPY21_RS06575	COG2176	DNA-directed DNA polymerase activity
GPY21_RS06620	COG0242	peptide deformylase activity
GPY21_RS06650	COG2239	Acts as a magnesium transporter
GPY21_RS06670	COG0346	lactoylglutathione lyase activity
GPY21_RS06675	COG1902	pentaerythritol trinitrate reductase activity
GPY21_RS06700	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY21_RS06710	COG0069	glutamate synthase activity
GPY21_RS06710	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY21_RS06720	COG4565	transcriptional regulatory protein
GPY21_RS06725	COG3290	protein histidine kinase activity
GPY21_RS06730	COG0471	metal ion transport
GPY21_RS06760	COG2076	Multidrug Resistance protein
GPY21_RS06775	COG0671	phosphoesterase, PA-phosphatase related
GPY21_RS06790	COG2962	Rard protein
GPY21_RS06810	COG0784	Response regulator, receiver
GPY21_RS06810	COG0835	chemotaxis
GPY21_RS06835	COG2197	response regulator
GPY21_RS06845	COG3706	GGDEF domain
GPY21_RS06850	COG2197	response regulator
GPY21_RS06855	COG3300	MHYT domain
GPY21_RS06855	COG5001	Diguanylate cyclase
GPY21_RS06870	COG0583	DNA-binding transcription factor activity
GPY21_RS06875	COG0583	DNA-binding transcription factor activity
GPY21_RS06935	COG4964	Belongs to the GSP D family
GPY21_RS06960	COG2207	Transcriptional regulator
GPY21_RS06980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY21_RS07000	COG1214	PFAM Peptidase M22, glycoprotease
GPY21_RS07000	COG0456	acetyltransferase
GPY21_RS07010	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY21_RS07015	COG1704	LemA family
GPY21_RS07020	COG0501	Belongs to the peptidase M48B family
GPY21_RS07050	COG0641	radical SAM
GPY21_RS07070	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY21_RS07075	COG1597	lipid kinase activity
GPY21_RS07080	COG0583	DNA-binding transcription factor activity
GPY21_RS07085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY21_RS07085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY21_RS07115	COG0714	Associated with various cellular activities
GPY21_RS07120	COG0641	radical SAM
GPY21_RS07125	COG3119	arylsulfatase activity
GPY21_RS07140	COG3119	arylsulfatase activity
GPY21_RS07145	COG3119	arylsulfatase activity
GPY21_RS07150	COG0745	RESPONSE REGULATOR receiver
GPY21_RS07165	COG0784	Response regulator, receiver
GPY21_RS07165	COG2198	Histidine kinase
GPY21_RS07165	COG2205	protein histidine kinase activity
GPY21_RS07170	COG1879	ABC-type sugar transport system periplasmic component
GPY21_RS07175	COG1803	Methylglyoxal synthase
GPY21_RS07180	COG0210	DNA helicase
GPY21_RS07185	COG1289	transmembrane transporter activity
GPY21_RS07220	COG4771	TonB-dependent receptor
GPY21_RS07220	COG1629	transport
GPY21_RS07235	COG0789	Transcriptional regulator
GPY21_RS07240	COG4604	ABC transporter, ATP-binding protein
GPY21_RS07245	COG4605	iron ion homeostasis
GPY21_RS07255	COG4607	ABC-type enterochelin transport system periplasmic component
GPY21_RS07280	COG2847	Copper chaperone PCu(A)C
GPY21_RS07285	COG0443	Heat shock 70 kDa protein
GPY21_RS07320	COG0625	glutathione transferase activity
GPY21_RS07335	COG4160	amino acid transport
GPY21_RS07340	COG4215	(ABC) transporter
GPY21_RS07345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY21_RS07350	COG1126	abc transporter atp-binding protein
GPY21_RS07360	COG1902	pentaerythritol trinitrate reductase activity
GPY21_RS07365	COG0109	protoheme IX farnesyltransferase activity
GPY21_RS07370	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY21_RS07375	COG1845	cytochrome c oxidase, subunit III
GPY21_RS07380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY21_RS07385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY21_RS07390	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS07400	COG1024	Enoyl-CoA hydratase
GPY21_RS07405	COG1024	Enoyl-CoA hydratase
GPY21_RS07420	COG0183	Belongs to the thiolase family
GPY21_RS07430	COG1960	acyl-CoA dehydrogenase activity
GPY21_RS07435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY21_RS07440	COG1024	Enoyl-CoA hydratase
GPY21_RS07450	COG5413	integral membrane protein
GPY21_RS07465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY21_RS07475	COG5001	Diguanylate cyclase
GPY21_RS07480	COG0513	Belongs to the DEAD box helicase family
GPY21_RS07485	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY21_RS07500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY21_RS07520	COG0641	radical SAM
GPY21_RS07545	COG0840	transmembrane signaling receptor activity
GPY21_RS07550	COG1119	ATPase activity
GPY21_RS07555	COG2200	EAL domain
GPY21_RS07575	COG0513	Belongs to the DEAD box helicase family
GPY21_RS07580	COG0523	cobalamin synthesis protein
GPY21_RS07590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY21_RS07600	COG0133	tryptophan synthase activity
GPY21_RS07605	COG4628	conserved protein (DUF2132)
GPY21_RS07610	COG0513	Belongs to the DEAD box helicase family
GPY21_RS07615	COG3530	Putative quorum-sensing-regulated virulence factor
GPY21_RS07640	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY21_RS07645	COG3186	Phenylalanine-4-hydroxylase
GPY21_RS07650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY21_RS07655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY21_RS07690	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY21_RS07695	COG1454	alcohol dehydrogenase
GPY21_RS07700	COG2133	pyrroloquinoline quinone binding
GPY21_RS07710	COG0783	Belongs to the Dps family
GPY21_RS07715	COG0840	transmembrane signaling receptor activity
GPY21_RS07725	COG1136	(ABC) transporter
GPY21_RS07725	COG0577	efflux transmembrane transporter activity
GPY21_RS07745	COG2199	diguanylate cyclase activity
GPY21_RS07760	COG3036	rescue of stalled ribosome
GPY21_RS07765	COG1278	Cold shock
GPY21_RS07800	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY21_RS07805	COG0109	protoheme IX farnesyltransferase activity
GPY21_RS07810	COG1612	heme a metabolic process
GPY21_RS07835	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY21_RS07845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY21_RS07850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY21_RS07860	COG1280	lysine exporter protein (LysE YggA)
GPY21_RS07865	COG2207	Transcriptional regulator
GPY21_RS07895	COG0697	spore germination
GPY21_RS07920	COG2814	Major facilitator Superfamily
GPY21_RS07925	COG0583	DNA-binding transcription factor activity
GPY21_RS07930	COG5001	Diguanylate cyclase
GPY21_RS07935	COG0739	heme binding
GPY21_RS07975	COG0814	amino acid
GPY21_RS07995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY21_RS08000	COG1072	(Pantothenic acid kinase))
GPY21_RS08010	COG1063	alcohol dehydrogenase
GPY21_RS08015	COG2213	PTS system mannitol-specific
GPY21_RS08020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY21_RS08040	COG0798	PFAM Bile acid sodium symporter
GPY21_RS08050	COG1881	PFAM PEBP family protein
GPY21_RS08060	COG2706	6-phosphogluconolactonase activity
GPY21_RS08075	COG1131	(ABC) transporter
GPY21_RS08080	COG0842	Transport permease protein
GPY21_RS08095	COG3383	formate dehydrogenase (NAD+) activity
GPY21_RS08120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY21_RS08140	COG2203	Gaf domain
GPY21_RS08140	COG2199	diguanylate cyclase activity
GPY21_RS08150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY21_RS08160	COG2067	long-chain fatty acid transport protein
GPY21_RS08170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS08180	COG1505	serine-type exopeptidase activity
GPY21_RS08185	COG0488	(ABC) transporter
GPY21_RS08190	COG0589	response to stress
GPY21_RS08195	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY21_RS08215	COG0366	Alpha amylase catalytic
GPY21_RS08225	COG4934	collagen metabolic process
GPY21_RS08240	COG0583	DNA-binding transcription factor activity
GPY21_RS08250	COG0783	Belongs to the Dps family
GPY21_RS08255	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY21_RS08290	COG2814	Major facilitator Superfamily
GPY21_RS08305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY21_RS08310	COG0835	chemotaxis
GPY21_RS08310	COG0784	Response regulator, receiver
GPY21_RS08320	COG0748	coenzyme F420 binding
GPY21_RS08325	COG3721	Heme iron utilization protein
GPY21_RS08335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY21_RS08340	COG0811	peptide transport
GPY21_RS08345	COG0848	biopolymer transport protein
GPY21_RS08355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY21_RS08360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY21_RS08400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY21_RS08405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY21_RS08410	COG3217	Mosc domain protein beta barrel domain protein
GPY21_RS08410	COG0633	Ferredoxin
GPY21_RS08410	COG0633	Ferredoxin
GPY21_RS08410	COG3217	Mosc domain protein beta barrel domain protein
GPY21_RS08420	COG0401	homolog of Blt101
GPY21_RS08430	COG0418	dihydroorotase activity
GPY21_RS08435	COG2354	Protein conserved in bacteria
GPY21_RS08465	COG2207	Transcriptional regulator
GPY21_RS08465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY21_RS08470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY21_RS08515	COG0513	Belongs to the DEAD box helicase family
GPY21_RS08525	COG0583	DNA-binding transcription factor activity
GPY21_RS08540	COG1902	pentaerythritol trinitrate reductase activity
GPY21_RS08545	COG1063	alcohol dehydrogenase
GPY21_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS08570	COG3122	Protein conserved in bacteria
GPY21_RS08590	COG0583	DNA-binding transcription factor activity
GPY21_RS08600	COG0252	asparaginase activity
GPY21_RS08605	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY21_RS08610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY21_RS08610	COG0574	Belongs to the PEP-utilizing enzyme family
GPY21_RS08630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY21_RS08635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY21_RS08650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS08655	COG2095	MarC family integral membrane protein
GPY21_RS08665	COG0742	ribosomal rna small subunit methyltransferase
GPY21_RS08670	COG0552	protein localization to endoplasmic reticulum
GPY21_RS08675	COG2884	Cell division ATP-binding protein ftsE
GPY21_RS08680	COG2177	Part of the ABC transporter FtsEX involved in
GPY21_RS08690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY21_RS08695	COG0705	Rhomboid family
GPY21_RS08700	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY21_RS08705	COG3161	chorismate lyase activity
GPY21_RS08710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY21_RS08715	COG2937	Belongs to the GPAT DAPAT family
GPY21_RS08725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY21_RS08730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY21_RS08735	COG0534	Mate efflux family protein
GPY21_RS08740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY21_RS08755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY21_RS08760	COG4206	TonB-dependent receptor
GPY21_RS08770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY21_RS08800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY21_RS08810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY21_RS08845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY21_RS08855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY21_RS08860	COG0250	Participates in transcription elongation, termination and antitermination
GPY21_RS08865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY21_RS08870	COG0081	regulation of translation
GPY21_RS08875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY21_RS08880	COG0222	ribosome binding
GPY21_RS08885	COG0085	RNA polymerase activity
GPY21_RS08890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY21_RS08895	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY21_RS08900	COG2816	NAD+ diphosphatase activity
GPY21_RS08915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY21_RS08920	COG1573	uracil-dna glycosylase
GPY21_RS08925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY21_RS08930	COG3068	Protein conserved in bacteria
GPY21_RS08935	COG1253	flavin adenine dinucleotide binding
GPY21_RS08950	COG0151	Belongs to the GarS family
GPY21_RS08960	COG0138	bifunctional purine biosynthesis protein purh
GPY21_RS08970	COG0789	Transcriptional regulator
GPY21_RS08975	COG3710	Transcriptional regulator
GPY21_RS08985	COG0531	amino acid
GPY21_RS08990	COG1982	Orn Lys Arg decarboxylase major
GPY21_RS09055	COG3706	GGDEF domain
GPY21_RS09060	COG0488	(ABC) transporter
GPY21_RS09065	COG2814	Major facilitator Superfamily
GPY21_RS09070	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY21_RS09075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY21_RS09080	COG2264	protein methyltransferase activity
GPY21_RS09090	COG0439	Biotin carboxylase
GPY21_RS09095	COG0511	ligase activity, forming carbon-carbon bonds
GPY21_RS09100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY21_RS09105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY21_RS09120	COG2814	Major facilitator Superfamily
GPY21_RS09125	COG0784	Response regulator, receiver
GPY21_RS09125	COG2205	protein histidine kinase activity
GPY21_RS09150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY21_RS09160	COG3263	regulation of cellular component size
GPY21_RS09170	COG4232	protein-disulfide reductase activity
GPY21_RS09175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY21_RS09180	COG1027	Aspartate ammonia-lyase
GPY21_RS09185	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY21_RS09190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY21_RS09200	COG2205	protein histidine kinase activity
GPY21_RS09205	COG0745	RESPONSE REGULATOR receiver
GPY21_RS09210	COG3678	ATP-independent chaperone mediated protein folding
GPY21_RS09220	COG0205	6-phosphofructokinase activity
GPY21_RS09225	COG0534	Mate efflux family protein
GPY21_RS09230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY21_RS09235	COG0459	protein refolding
GPY21_RS09250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY21_RS09265	COG1509	lysine 2,3-aminomutase activity
GPY21_RS09270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY21_RS09280	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY21_RS09285	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY21_RS09290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY21_RS09295	COG1053	succinate dehydrogenase
GPY21_RS09305	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY21_RS09325	COG4942	peptidase
GPY21_RS09330	COG1045	serine acetyltransferase
GPY21_RS09335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY21_RS09340	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY21_RS09345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY21_RS09350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY21_RS09365	COG0471	metal ion transport
GPY21_RS09370	COG0688	phosphatidylethanolamine metabolic process
GPY21_RS09375	COG1162	GTPase activity
GPY21_RS09380	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY21_RS09450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY21_RS09455	COG0802	atpase or kinase
GPY21_RS09460	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPY21_RS09465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY21_RS09470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY21_RS09480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY21_RS09485	COG0330	HflC and HflK could
GPY21_RS09490	COG0330	HflC and HflK could
GPY21_RS09495	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY21_RS09500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY21_RS09510	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY21_RS09515	COG1017	nitric oxide dioxygenase activity
GPY21_RS09515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY21_RS09520	COG1959	2 iron, 2 sulfur cluster binding
GPY21_RS09525	COG0557	exoribonuclease II activity
GPY21_RS09530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY21_RS09535	COG0546	phosphoglycolate phosphatase activity
GPY21_RS09540	COG0180	Tryptophanyl-tRNA synthetase
GPY21_RS09570	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY21_RS09575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY21_RS09585	COG1012	belongs to the aldehyde dehydrogenase family
GPY21_RS09595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY21_RS09600	COG3954	Phosphoribulokinase
GPY21_RS09605	COG3089	Belongs to the UPF0270 family
GPY21_RS09610	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY21_RS09620	COG0488	(ABC) transporter
GPY21_RS09630	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY21_RS09645	COG1047	Peptidyl-prolyl cis-trans
GPY21_RS09655	COG1446	asparaginase
GPY21_RS09660	COG2900	Belongs to the SlyX family
GPY21_RS09670	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY21_RS09675	COG2964	Protein conserved in bacteria
GPY21_RS09680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY21_RS09685	COG2923	Belongs to the DsrF TusC family
GPY21_RS09690	COG2168	tRNA wobble position uridine thiolation
GPY21_RS09700	COG0049	tRNA binding
GPY21_RS09705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY21_RS09710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY21_RS09715	COG2906	2 iron, 2 sulfur cluster binding
GPY21_RS09725	COG0281	malic enzyme
GPY21_RS09735	COG0626	cystathionine gamma-synthase activity
GPY21_RS09740	COG0527	aspartate kinase activity
GPY21_RS09740	COG0460	homoserine dehydrogenase
GPY21_RS09745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY21_RS09750	COG1695	Transcriptional regulator
GPY21_RS09755	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY21_RS09760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY21_RS09765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY21_RS09770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY21_RS09775	COG0137	argininosuccinate synthase activity
GPY21_RS09780	COG0165	Argininosuccinate lyase
GPY21_RS09780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY21_RS09795	COG0678	peroxiredoxin activity
GPY21_RS09795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY21_RS09805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY21_RS09835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY21_RS09840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY21_RS09850	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY21_RS09855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY21_RS09860	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY21_RS09865	COG2965	DNA replication, synthesis of RNA primer
GPY21_RS09875	COG0359	binds to the 23S rRNA
GPY21_RS09885	COG0305	Participates in initiation and elongation during chromosome replication
GPY21_RS09890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY21_RS09900	COG0432	Pfam Uncharacterised protein family UPF0047
GPY21_RS09905	COG0166	Belongs to the GPI family
GPY21_RS09915	COG0735	belongs to the Fur family
GPY21_RS09925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY21_RS09950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY21_RS09955	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY21_RS09960	COG0175	sulfate reduction
GPY21_RS10035	COG0646	methionine synthase
GPY21_RS10035	COG1410	methionine synthase
GPY21_RS10040	COG0527	aspartate kinase activity
GPY21_RS10045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY21_RS10055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY21_RS10070	COG0629	single-stranded DNA binding
GPY21_RS10075	COG2200	EAL domain
GPY21_RS10075	COG2199	diguanylate cyclase activity
GPY21_RS10100	COG3267	Type II secretory pathway component ExeA
GPY21_RS10100	COG3409	Peptidoglycan-binding domain 1 protein
GPY21_RS10110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY21_RS10115	COG1459	type II secretion system
GPY21_RS10160	COG1077	Cell shape determining protein MreB Mrl
GPY21_RS10165	COG1792	Involved in formation and maintenance of cell shape
GPY21_RS10170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY21_RS10175	COG0424	maF-like protein
GPY21_RS10180	COG1530	ribonuclease E activity
GPY21_RS10185	COG3164	Protein of unknown function
GPY21_RS10190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY21_RS10195	COG0312	modulator of DNA gyrase
GPY21_RS10200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY21_RS10205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY21_RS10220	COG0564	pseudouridine synthase activity
GPY21_RS10225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY21_RS10230	COG3028	Belongs to the UPF0307 family
GPY21_RS10235	COG0312	modulator of DNA gyrase
GPY21_RS10240	COG2239	Acts as a magnesium transporter
GPY21_RS10245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY21_RS10250	COG1660	Displays ATPase and GTPase activities
GPY21_RS10255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY21_RS10260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY21_RS10270	COG1137	ATPase activity
GPY21_RS10275	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY21_RS10285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY21_RS10285	COG0517	IMP dehydrogenase activity
GPY21_RS10295	COG1127	ABC transporter
GPY21_RS10300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY21_RS10305	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY21_RS10310	COG2854	intermembrane phospholipid transfer
GPY21_RS10320	COG5007	Belongs to the BolA IbaG family
GPY21_RS10325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY21_RS10330	COG0204	Acyl-transferase
GPY21_RS10335	COG0251	oxidation-reduction process
GPY21_RS10340	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY21_RS10345	COG0540	Belongs to the ATCase OTCase family
GPY21_RS10355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY21_RS10360	COG2235	arginine
GPY21_RS10390	COG0525	valine-tRNA ligase activity
GPY21_RS10395	COG2927	DNA polymerase III (CHI subunit)
GPY21_RS10400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY21_RS10405	COG0795	lipopolysaccharide-transporting ATPase activity
GPY21_RS10410	COG0795	lipopolysaccharide-transporting ATPase activity
GPY21_RS10420	COG4325	translation initiation factor activity
GPY21_RS10435	COG0726	polysaccharide deacetylase
GPY21_RS10440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY21_RS10445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY21_RS10450	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY21_RS10455	COG1486	melibiose metabolic process
GPY21_RS10460	COG3394	polysaccharide catabolic process
GPY21_RS10470	COG3437	response regulator, receiver
GPY21_RS10520	COG1012	belongs to the aldehyde dehydrogenase family
GPY21_RS10590	COG0741	lytic transglycosylase activity
GPY21_RS10595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY21_RS10605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY21_RS10615	COG2066	Belongs to the glutaminase family
GPY21_RS10620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY21_RS10625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY21_RS10635	COG1872	DUF167
GPY21_RS10640	COG0762	integral membrane protein
GPY21_RS10645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY21_RS10650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY21_RS10665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY21_RS10670	COG1678	Uncharacterized ACR, COG1678
GPY21_RS10675	COG0189	ligase activity
GPY21_RS10680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY21_RS10685	COG2356	endonuclease I
GPY21_RS10690	COG3091	SprT-like family
GPY21_RS10700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY21_RS10710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY21_RS10715	COG0583	DNA-binding transcription factor activity
GPY21_RS10720	COG4771	TonB-dependent receptor
GPY21_RS10725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY21_RS10730	COG0126	phosphoglycerate kinase activity
GPY21_RS10735	COG0191	fructose-bisphosphate aldolase activity
GPY21_RS10740	COG0668	transmembrane transport
GPY21_RS10745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY21_RS10755	COG0583	DNA-binding transcription factor activity
GPY21_RS10765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY21_RS10770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY21_RS10775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY21_RS10785	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY21_RS10795	COG3079	Belongs to the UPF0149 family
GPY21_RS10800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY21_RS10805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY21_RS10820	COG0354	folic acid binding
GPY21_RS10825	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY21_RS10835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY21_RS10845	COG1595	DNA-templated transcription, initiation
GPY21_RS10850	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY21_RS10860	COG3086	response to oxidative stress
GPY21_RS10865	COG0481	GTPase activity
GPY21_RS10870	COG0681	Belongs to the peptidase S26 family
GPY21_RS10875	COG0571	ribonuclease III activity
GPY21_RS10880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY21_RS10885	COG1381	Involved in DNA repair and RecF pathway recombination
GPY21_RS10890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY21_RS10895	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY21_RS10905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY21_RS10915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY21_RS10920	COG3956	TIGRFAM MazG family protein
GPY21_RS10925	COG0504	CTP synthase activity
GPY21_RS10930	COG0148	phosphopyruvate hydratase activity
GPY21_RS10935	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY21_RS10940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY21_RS10945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY21_RS10950	COG0585	pseudouridine synthase activity
GPY21_RS10955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY21_RS10960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY21_RS10975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY21_RS10980	COG1546	Belongs to the CinA family
GPY21_RS10985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY21_RS10990	COG2137	regulation of response to DNA damage stimulus
GPY21_RS10995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY21_RS11000	COG0527	aspartate kinase activity
GPY21_RS11060	COG3630	sodium ion export across plasma membrane
GPY21_RS11065	COG5016	pyruvate
GPY21_RS11065	COG0511	ligase activity, forming carbon-carbon bonds
GPY21_RS11070	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY21_RS11075	COG1063	alcohol dehydrogenase
GPY21_RS11080	COG1238	metal cluster binding
GPY21_RS11085	COG0612	Peptidase, M16
GPY21_RS11090	COG2918	glutathione biosynthetic process
GPY21_RS11100	COG1854	S-ribosylhomocysteine lyase activity
GPY21_RS11105	COG4536	flavin adenine dinucleotide binding
GPY21_RS11110	COG4137	Cytochrome C assembly protein
GPY21_RS11115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY21_RS11120	COG0228	four-way junction DNA binding
GPY21_RS11125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY21_RS11130	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY21_RS11135	COG0335	large ribosomal subunit rRNA binding
GPY21_RS11140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY21_RS11145	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY21_RS11150	COG0237	dephospho-CoA kinase activity
GPY21_RS11160	COG1459	type II secretion system
GPY21_RS11165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY21_RS11170	COG4969	Belongs to the N-Me-Phe pilin family
GPY21_RS11175	COG0157	Belongs to the NadC ModD family
GPY21_RS11185	COG2186	Transcriptional regulator
GPY21_RS11190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY21_RS11195	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY21_RS11200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY21_RS11215	COG0288	reversible hydration of carbon dioxide
GPY21_RS11220	COG0659	secondary active sulfate transmembrane transporter activity
GPY21_RS11230	COG1131	(ABC) transporter
GPY21_RS11235	COG0842	Transport permease protein
GPY21_RS11240	COG1560	Kdo2-lipid A biosynthetic process
GPY21_RS11250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY21_RS11255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY21_RS11260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY21_RS11275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY21_RS11285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY21_RS11290	COG1489	DNA binding
GPY21_RS11295	COG1643	Atp-dependent helicase
GPY21_RS11300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY21_RS11305	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY21_RS11310	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY21_RS11315	COG3112	Uncharacterised protein family (UPF0231)
GPY21_RS11325	COG0004	ammonium transporteR
GPY21_RS11330	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY21_RS11340	COG3842	ATPase activity
GPY21_RS11345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY21_RS11360	COG2971	BadF BadG BcrA BcrD
GPY21_RS11370	COG4608	Belongs to the ABC transporter superfamily
GPY21_RS11375	COG0444	Belongs to the ABC transporter superfamily
GPY21_RS11380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY21_RS11390	COG0747	negative chemotaxis
GPY21_RS11395	COG2205	protein histidine kinase activity
GPY21_RS11395	COG2198	Histidine kinase
GPY21_RS11395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY21_RS11395	COG0784	Response regulator, receiver
GPY21_RS11400	COG2813	Specifically methylates the guanine in position
GPY21_RS11405	COG0628	permease
GPY21_RS11410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY21_RS11415	COG0316	Belongs to the HesB IscA family
GPY21_RS11430	COG0739	heme binding
GPY21_RS11435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY21_RS11445	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY21_RS11450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY21_RS11455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY21_RS11460	COG1534	Rna-binding protein
GPY21_RS11465	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY21_RS11470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY21_RS11475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY21_RS11480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY21_RS11490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY21_RS11505	COG0779	Required for maturation of 30S ribosomal subunits
GPY21_RS11510	COG0195	Participates in both transcription termination and antitermination
GPY21_RS11515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY21_RS11520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY21_RS11525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY21_RS11530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY21_RS11535	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY21_RS11550	COG0534	Mate efflux family protein
GPY21_RS11575	COG3153	acetyltransferase
GPY21_RS11595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY21_RS11605	COG0084	hydrolase, TatD family'
GPY21_RS11610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY21_RS11615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY21_RS11620	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY21_RS11625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY21_RS11630	COG0813	purine-nucleoside phosphorylase activity
GPY21_RS11640	COG0560	Phosphoserine phosphatase
GPY21_RS11650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY21_RS11655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY21_RS11660	COG0583	DNA-binding transcription factor activity
GPY21_RS11670	COG1022	Amp-dependent synthetase and ligase
GPY21_RS11675	COG2169	Transcriptional regulator
GPY21_RS11700	COG4964	Belongs to the GSP D family
GPY21_RS11760	COG0583	DNA-binding transcription factor activity
GPY21_RS11765	COG0531	amino acid
GPY21_RS11770	COG2731	YhcH YjgK YiaL family protein
GPY21_RS11775	COG3250	beta-galactosidase activity
GPY21_RS11780	COG1609	Transcriptional regulator
GPY21_RS11790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY21_RS11800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY21_RS11805	COG2017	converts alpha-aldose to the beta-anomer
GPY21_RS11820	COG2211	Major facilitator Superfamily
GPY21_RS11825	COG1609	Transcriptional regulator
GPY21_RS11830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY21_RS11845	COG0598	Magnesium transport protein CorA
GPY21_RS11850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY21_RS11855	COG1349	DNA-binding transcription factor activity
GPY21_RS11860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY21_RS11865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY21_RS11880	COG2271	Major facilitator Superfamily
GPY21_RS11885	COG0584	glycerophosphoryl diester phosphodiesterase
GPY21_RS11890	COG2171	N-acyltransferase activity
GPY21_RS11895	COG3141	response to X-ray
GPY21_RS11915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY21_RS11920	COG1074	ATP-dependent DNA helicase activity
GPY21_RS11925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY21_RS11950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY21_RS11950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY21_RS11960	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY21_RS11965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY21_RS11970	COG2166	iron-sulfur cluster assembly
GPY21_RS11975	COG3706	GGDEF domain
GPY21_RS11980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY21_RS11985	COG0693	protein deglycase activity
GPY21_RS11990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY21_RS12015	COG1595	DNA-templated transcription, initiation
GPY21_RS12035	COG3056	Lipoprotein
GPY21_RS12040	COG2813	Specifically methylates the guanine in position
GPY21_RS12045	COG0271	Belongs to the BolA IbaG family
GPY21_RS12050	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY21_RS12055	COG1805	sodium ion transport
GPY21_RS12060	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY21_RS12065	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY21_RS12070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY21_RS12075	COG2871	sodium ion transport
GPY21_RS12080	COG1477	protein flavinylation
GPY21_RS12095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY21_RS12100	COG0514	ATP-dependent DNA helicase (RecQ)
GPY21_RS12105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY21_RS12120	COG0733	neurotransmitter:sodium symporter activity
GPY21_RS12140	COG0442	prolyl-tRNA aminoacylation
GPY21_RS12145	COG1720	tRNA m6t6A37 methyltransferase activity
GPY21_RS12150	COG0254	rRNA binding
GPY21_RS12165	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY21_RS12170	COG1671	Belongs to the UPF0178 family
GPY21_RS12195	COG3098	single-species biofilm formation
GPY21_RS12200	COG0564	pseudouridine synthase activity
GPY21_RS12210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY21_RS12215	COG0024	Methionine aminopeptidase
GPY21_RS12220	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY21_RS12225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY21_RS12230	COG0528	UMP kinase activity
GPY21_RS12235	COG0233	cytoplasmic translational termination
GPY21_RS12240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY21_RS12245	COG0575	Belongs to the CDS family
GPY21_RS12250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY21_RS12255	COG0750	zinc metalloprotease
GPY21_RS12265	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY21_RS12270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY21_RS12275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY21_RS12280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY21_RS12285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY21_RS12290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY21_RS12295	COG0587	DNA-directed DNA polymerase activity
GPY21_RS12300	COG0825	malonyl-CoA metabolic process
GPY21_RS12305	COG0037	tRNA processing
GPY21_RS12315	COG0347	Belongs to the P(II) protein family
GPY21_RS12320	COG3021	interspecies interaction between organisms
GPY21_RS12330	COG1388	LysM domain
GPY21_RS12330	COG0741	lytic transglycosylase activity
GPY21_RS12335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY21_RS12340	COG2226	methyltransferase
GPY21_RS12345	COG0328	RNA-DNA hybrid ribonuclease activity
GPY21_RS12350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY21_RS12365	COG1960	acyl-CoA dehydrogenase activity
GPY21_RS12370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY21_RS12375	COG0121	glutamine amidotransferase
GPY21_RS12380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY21_RS12385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY21_RS12390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY21_RS12395	COG2233	PERMEase
GPY21_RS12415	COG1393	Belongs to the ArsC family
GPY21_RS12420	COG4783	chaperone-mediated protein folding
GPY21_RS12435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY21_RS12440	COG2716	regulation of RNA biosynthetic process
GPY21_RS12445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY21_RS12465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY21_RS12470	COG1393	Belongs to the ArsC family
GPY21_RS12500	COG2837	iron assimilation
GPY21_RS12505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS12515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS12520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS12525	COG1334	flagellar protein FlaG
GPY21_RS12530	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY21_RS12540	COG1516	flagellar protein fliS
GPY21_RS12550	COG4191	Histidine kinase
GPY21_RS12555	COG2204	response regulator
GPY21_RS12560	COG1677	Flagellar hook-basal body complex protein FliE
GPY21_RS12570	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY21_RS12620	COG1987	bacterial-type flagellum assembly
GPY21_RS12625	COG1684	flagellar biosynthetic protein fliR
GPY21_RS12645	COG0455	bacterial-type flagellum organization
GPY21_RS12660	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY21_RS12665	COG2198	Histidine kinase
GPY21_RS12665	COG0643	Histidine kinase
GPY21_RS12670	COG2201	protein-glutamate methylesterase activity
GPY21_RS12675	COG1192	Involved in chromosome partitioning
GPY21_RS12685	COG0835	chemotaxis
GPY21_RS12695	COG4133	protoheme IX ABC transporter activity
GPY21_RS12700	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY21_RS12705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY21_RS12710	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY21_RS12715	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY21_RS12720	COG1138	Cytochrome C-type biogenesis protein
GPY21_RS12725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY21_RS12740	COG2853	Lipoprotein
GPY21_RS12745	COG2067	long-chain fatty acid transport protein
GPY21_RS12750	COG2067	long-chain fatty acid transport protein
GPY21_RS12765	COG0183	Belongs to the thiolase family
GPY21_RS12770	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY21_RS12770	COG1024	Enoyl-CoA hydratase
GPY21_RS12785	COG2062	phosphohistidine phosphatase, SixA
GPY21_RS12790	COG2840	Smr protein MutS2
GPY21_RS12795	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY21_RS12800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY21_RS12805	COG2860	membrane
GPY21_RS12815	COG3101	peptidyl-lysine hydroxylation
GPY21_RS12830	COG0431	NADPH-dependent FMN reductase
GPY21_RS12835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY21_RS12835	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY21_RS12840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY21_RS12845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY21_RS12850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY21_RS12860	COG0101	tRNA pseudouridine synthase activity
GPY21_RS12865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY21_RS12870	COG0285	dihydrofolate synthase activity
GPY21_RS12875	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY21_RS12880	COG1286	toxin biosynthetic process
GPY21_RS12885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY21_RS12890	COG0583	DNA-binding transcription factor activity
GPY21_RS12895	COG0745	RESPONSE REGULATOR receiver
GPY21_RS12905	COG2832	Protein of unknown function (DUF454)
GPY21_RS12910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY21_RS12920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY21_RS12925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY21_RS12930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY21_RS12935	COG0814	amino acid
GPY21_RS12940	COG0251	oxidation-reduction process
GPY21_RS12945	COG3681	Belongs to the UPF0597 family
GPY21_RS12960	COG2261	transglycosylase associated protein
GPY21_RS12965	COG2983	Belongs to the UPF0260 family
GPY21_RS12970	COG0668	transmembrane transport
GPY21_RS12975	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY21_RS12980	COG0346	lactoylglutathione lyase activity
GPY21_RS12990	COG1785	Belongs to the alkaline phosphatase family
GPY21_RS13010	COG2226	methyltransferase
GPY21_RS13025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY21_RS13030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY21_RS13040	COG3139	Protein of unknown function (DUF1315)
GPY21_RS13045	COG0252	asparaginase activity
GPY21_RS13050	COG0616	signal peptide processing
GPY21_RS13055	COG1902	pentaerythritol trinitrate reductase activity
GPY21_RS13055	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY21_RS13060	COG0778	Nitroreductase
GPY21_RS13065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY21_RS13085	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY21_RS13095	COG3083	sulfuric ester hydrolase activity
GPY21_RS13100	COG3082	Protein of unknown function (DUF1414)
GPY21_RS13105	COG3081	Nucleoid-associated protein
GPY21_RS13120	COG1757	Na H antiporter
GPY21_RS13125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY21_RS13130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY21_RS13135	COG2095	MarC family integral membrane protein
GPY21_RS13140	COG1012	belongs to the aldehyde dehydrogenase family
GPY21_RS13140	COG1454	alcohol dehydrogenase
GPY21_RS13160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY21_RS13170	COG2056	Na+-H+ antiporter family
GPY21_RS13175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY21_RS13190	COG2885	chlorophyll binding
GPY21_RS13200	COG0346	lactoylglutathione lyase activity
GPY21_RS13205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY21_RS13210	COG4660	Part of a membrane complex involved in electron transport
GPY21_RS13215	COG4659	FMN binding
GPY21_RS13220	COG4658	electron transport chain
GPY21_RS13225	COG4656	Part of a membrane complex involved in electron transport
GPY21_RS13230	COG2878	Part of a membrane complex involved in electron transport
GPY21_RS13235	COG4657	Part of a membrane complex involved in electron transport
GPY21_RS13250	COG0556	nucleotide-excision repair
GPY21_RS13255	COG2204	response regulator
GPY21_RS13260	COG2198	Histidine kinase
GPY21_RS13265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY21_RS13270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY21_RS13275	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY21_RS13280	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY21_RS13285	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY21_RS13290	COG0314	molybdopterin synthase activity
GPY21_RS13300	COG0601	transmembrane transport
GPY21_RS13305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY21_RS13310	COG0444	Belongs to the ABC transporter superfamily
GPY21_RS13320	COG0435	Glutathione S-transferase
GPY21_RS13330	COG3174	membrane
GPY21_RS13335	COG0280	phosphate acetyltransferase
GPY21_RS13335	COG0857	belongs to the CobB CobQ family
GPY21_RS13340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY21_RS13345	COG3092	negative regulation of chromosome organization
GPY21_RS13355	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY21_RS13360	COG1122	ATPase activity
GPY21_RS13365	COG0366	Alpha amylase catalytic
GPY21_RS13370	COG3706	GGDEF domain
GPY21_RS13370	COG0745	RESPONSE REGULATOR receiver
GPY21_RS13375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY21_RS13380	COG0653	protein targeting
GPY21_RS13385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY21_RS13390	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY21_RS13395	COG2186	Transcriptional regulator
GPY21_RS13405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY21_RS13405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY21_RS13410	COG0489	protein tyrosine kinase activity
GPY21_RS13415	COG0572	uridine kinase
GPY21_RS13425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY21_RS13430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY21_RS13435	COG0659	secondary active sulfate transmembrane transporter activity
GPY21_RS13440	COG1530	ribonuclease E activity
GPY21_RS13445	COG0564	pseudouridine synthase activity
GPY21_RS13450	COG0424	maF-like protein
GPY21_RS13455	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY21_RS13465	COG0416	fatty acid biosynthetic process
GPY21_RS13470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY21_RS13500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY21_RS13505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY21_RS13515	COG0084	hydrolase, TatD family'
GPY21_RS13520	COG1263	PTS System
GPY21_RS13520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY21_RS13540	COG0733	neurotransmitter:sodium symporter activity
GPY21_RS13555	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY21_RS13560	COG0469	pyruvate kinase activity
GPY21_RS13565	COG1940	carbohydrate kinase activity
GPY21_RS13570	COG0835	chemotaxis
GPY21_RS13570	COG0784	Response regulator, receiver
GPY21_RS13575	COG0587	DNA-directed DNA polymerase activity
GPY21_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS13595	COG0616	signal peptide processing
GPY21_RS13600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY21_RS13605	COG0539	negative regulation of cytoplasmic translation
GPY21_RS13615	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY21_RS13620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY21_RS13625	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY21_RS13630	COG4166	transmembrane transport
GPY21_RS13645	COG0463	Glycosyl transferase, family 2
GPY21_RS13655	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY21_RS13665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY21_RS13665	COG3008	intermembrane lipid transfer
GPY21_RS13670	COG2995	paraquat-inducible protein a
GPY21_RS13675	COG3258	Cytochrome c
GPY21_RS13680	COG2863	cytochrome
GPY21_RS13720	COG4232	protein-disulfide reductase activity
GPY21_RS13725	COG3118	belongs to the thioredoxin family
GPY21_RS13755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS13765	COG0577	efflux transmembrane transporter activity
GPY21_RS13765	COG1136	(ABC) transporter
GPY21_RS13770	COG1136	(ABC) transporter
GPY21_RS13770	COG0577	efflux transmembrane transporter activity
GPY21_RS13775	COG1136	(ABC) transporter
GPY21_RS13775	COG0577	efflux transmembrane transporter activity
GPY21_RS13780	COG1335	isochorismatase
GPY21_RS13830	COG3850	Histidine kinase
GPY21_RS13830	COG5002	protein histidine kinase activity
GPY21_RS13835	COG0745	RESPONSE REGULATOR receiver
GPY21_RS13845	COG0840	transmembrane signaling receptor activity
GPY21_RS13850	COG1032	radical SAM domain protein
GPY21_RS13855	COG2203	Gaf domain
GPY21_RS13855	COG3706	GGDEF domain
GPY21_RS13855	COG4251	negative regulation of phosphorylation
GPY21_RS13855	COG5001	Diguanylate cyclase
GPY21_RS13870	COG0583	DNA-binding transcription factor activity
GPY21_RS13880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY21_RS13890	COG2350	Protein conserved in bacteria
GPY21_RS13895	COG1607	acyl-coa hydrolase
GPY21_RS13900	COG2917	probably involved in intracellular septation
GPY21_RS13920	COG1301	dicarboxylic acid transport
GPY21_RS13930	COG0318	PFAM AMP-dependent synthetase and ligase
GPY21_RS13935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY21_RS13940	COG0159	tryptophan synthase activity
GPY21_RS13945	COG0133	tryptophan synthase activity
GPY21_RS13950	COG0134	indole-3-glycerol-phosphate synthase activity
GPY21_RS13950	COG0135	phosphoribosylanthranilate isomerase activity
GPY21_RS13955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY21_RS13960	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY21_RS13965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY21_RS13975	COG0613	PHP domain protein
GPY21_RS13980	COG0009	L-threonylcarbamoyladenylate synthase
GPY21_RS13990	COG1187	pseudouridine synthase activity
GPY21_RS14000	COG3099	Belongs to the UPF0263 family
GPY21_RS14005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY21_RS14015	COG0417	DNA replication proofreading
GPY21_RS14020	COG2197	response regulator
GPY21_RS14025	COG0322	excinuclease ABC activity
GPY21_RS14065	COG0019	diaminopimelate decarboxylase activity
GPY21_RS14090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY21_RS14095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY21_RS14100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY21_RS14120	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY21_RS14130	COG0437	4 iron, 4 sulfur cluster binding
GPY21_RS14135	COG3301	Polysulphide reductase, NrfD
GPY21_RS14140	COG1138	Cytochrome C-type biogenesis protein
GPY21_RS14150	COG3088	subunit of a heme lyase
GPY21_RS14150	COG4235	cytochrome complex assembly
GPY21_RS14160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY21_RS14185	COG2989	Protein conserved in bacteria
GPY21_RS14190	COG3108	Peptidase M15
GPY21_RS14195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY21_RS14210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY21_RS14235	COG1846	Transcriptional regulator
GPY21_RS14240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY21_RS14245	COG0840	transmembrane signaling receptor activity
GPY21_RS14265	COG1448	Aminotransferase
GPY21_RS14290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY21_RS14300	COG0017	Asparaginyl-tRNA synthetase
GPY21_RS14310	COG0720	synthase
GPY21_RS14320	COG2200	EAL domain
GPY21_RS14325	COG1760	l-serine dehydratase
GPY21_RS14330	COG0814	amino acid
GPY21_RS14335	COG0494	nUDIX hydrolase
GPY21_RS14345	COG2205	protein histidine kinase activity
GPY21_RS14345	COG0784	Response regulator, receiver
GPY21_RS14350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY21_RS14370	COG3106	COG3106 Predicted ATPase
GPY21_RS14375	COG3768	UPF0283 membrane protein
GPY21_RS14385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY21_RS14525	COG0346	lactoylglutathione lyase activity
GPY21_RS14615	COG2026	Addiction module toxin, RelE StbE family
GPY21_RS14655	COG1051	belongs to the nudix hydrolase family
GPY21_RS14915	COG1192	Involved in chromosome partitioning
GPY21_RS14995	COG0456	acetyltransferase
GPY21_RS15010	COG0346	lactoylglutathione lyase activity
GPY21_RS15190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY21_RS15190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY21_RS15390	COG1757	Na H antiporter
GPY21_RS15395	COG0174	glutamine synthetase
GPY21_RS15405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY21_RS15410	COG1917	Cupin 2, conserved barrel domain protein
GPY21_RS15410	COG1396	sequence-specific DNA binding
GPY21_RS15415	COG1012	belongs to the aldehyde dehydrogenase family
GPY21_RS15420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY21_RS15430	COG2957	Belongs to the agmatine deiminase family
GPY21_RS15435	COG1012	belongs to the aldehyde dehydrogenase family
GPY21_RS15440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY21_RS15445	COG1227	inorganic diphosphatase activity
GPY21_RS15455	COG2200	EAL domain
GPY21_RS15455	COG2771	luxR family
GPY21_RS15465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY21_RS15480	COG1846	Transcriptional regulator
GPY21_RS15485	COG2315	Protein conserved in bacteria
GPY21_RS15505	COG0110	maltose O-acetyltransferase activity
GPY21_RS15535	COG3063	Type IV pilus biogenesis stability protein PilW
GPY21_RS15540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY21_RS15555	COG0531	amino acid
GPY21_RS15565	COG1560	Kdo2-lipid A biosynthetic process
GPY21_RS15570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY21_RS15575	COG1280	lysine exporter protein (LysE YggA)
GPY21_RS15585	COG1115	amino acid carrier protein
GPY21_RS15610	COG1368	sulfuric ester hydrolase activity
GPY21_RS15615	COG0642	Histidine kinase
GPY21_RS15620	COG0745	RESPONSE REGULATOR receiver
GPY21_RS15630	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS15640	COG1022	Amp-dependent synthetase and ligase
GPY21_RS15650	COG2113	Glycine betaine
GPY21_RS15655	COG4176	ABC-type proline glycine betaine transport system permease component
GPY21_RS15675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY21_RS15680	COG0456	acetyltransferase
GPY21_RS15685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY21_RS15690	COG0662	Cupin 2, conserved barrel domain protein
GPY21_RS15695	COG0527	aspartate kinase activity
GPY21_RS15700	COG1858	cytochrome C peroxidase
GPY21_RS15715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS15730	COG3290	protein histidine kinase activity
GPY21_RS15735	COG4565	transcriptional regulatory protein
GPY21_RS15740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY21_RS15745	COG0363	glucosamine-6-phosphate deaminase activity
GPY21_RS15750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY21_RS15770	COG3284	Transcriptional regulator
GPY21_RS15775	COG1012	belongs to the aldehyde dehydrogenase family
GPY21_RS15845	COG4669	(LipO)protein
GPY21_RS15865	COG3177	Filamentation induced by cAMP protein fic
GPY21_RS15915	COG4792	protein secretion
GPY21_RS15920	COG4791	protein targeting
GPY21_RS15925	COG4794	Type iii secretion
GPY21_RS15930	COG4790	Type iii secretion
GPY21_RS15935	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY21_RS16000	COG0457	Tetratricopeptide repeat
GPY21_RS16020	COG0730	response to heat
GPY21_RS16050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY21_RS16055	COG0372	Belongs to the citrate synthase family
GPY21_RS16065	COG2828	Protein conserved in bacteria
GPY21_RS16075	COG0456	acetyltransferase
GPY21_RS16090	COG0561	phosphatase activity
GPY21_RS16095	COG0602	queuosine metabolic process
GPY21_RS16100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY21_RS16105	COG3706	GGDEF domain
GPY21_RS16145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY21_RS16150	COG0840	transmembrane signaling receptor activity
GPY21_RS16155	COG1254	Belongs to the acylphosphatase family
GPY21_RS16160	COG2920	part of a sulfur-relay system
GPY21_RS16170	COG0670	Belongs to the BI1 family
GPY21_RS16175	COG1126	abc transporter atp-binding protein
GPY21_RS16180	COG0765	amino acid transport
GPY21_RS16185	COG4597	amino acid ABC transporter
GPY21_RS16190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY21_RS16205	COG1666	GTP binding
GPY21_RS16210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY21_RS16230	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY21_RS16230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY21_RS16235	COG3008	intermembrane lipid transfer
GPY21_RS16240	COG2995	paraquat-inducible protein a
GPY21_RS16245	COG1132	(ABC) transporter
GPY21_RS16250	COG1956	GAF domain-containing protein
GPY21_RS16255	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY21_RS16270	COG0308	aminopeptidase N
GPY21_RS16280	COG2902	Dehydrogenase
GPY21_RS16285	COG0167	dihydroorotate dehydrogenase activity
GPY21_RS16300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY21_RS16300	COG0116	Belongs to the methyltransferase superfamily
GPY21_RS16325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY21_RS16330	COG1067	ATP-dependent peptidase activity
GPY21_RS16335	COG3120	sequence-specific DNA binding
GPY21_RS16370	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY21_RS16385	COG2010	Cytochrome c
GPY21_RS16395	COG2217	Heavy metal translocating P-type atpase
GPY21_RS16410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY21_RS16415	COG0589	response to stress
GPY21_RS16425	COG0037	tRNA processing
GPY21_RS16445	COG3842	ATPase activity
GPY21_RS16450	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY21_RS16455	COG1177	transmembrane transport
GPY21_RS16460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY21_RS16465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY21_RS16470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY21_RS16480	COG0004	ammonium transporteR
GPY21_RS16520	COG0437	4 iron, 4 sulfur cluster binding
GPY21_RS16525	COG3383	formate dehydrogenase (NAD+) activity
GPY21_RS16525	COG0243	molybdopterin cofactor binding
GPY21_RS16535	COG3381	protein complex oligomerization
GPY21_RS16560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY21_RS16565	COG0488	(ABC) transporter
GPY21_RS16575	COG4191	Histidine kinase
GPY21_RS16580	COG2204	response regulator
GPY21_RS16600	COG3842	ATPase activity
GPY21_RS16605	COG0746	molybdenum cofactor guanylyltransferase activity
GPY21_RS16610	COG0303	'Molybdopterin
GPY21_RS16620	COG1940	carbohydrate kinase activity
GPY21_RS16660	COG3290	protein histidine kinase activity
GPY21_RS16660	COG0840	transmembrane signaling receptor activity
GPY21_RS16665	COG0791	NLP P60 protein
GPY21_RS16675	COG3706	GGDEF domain
GPY21_RS16680	COG2201	protein-glutamate methylesterase activity
GPY21_RS16695	COG0307	riboflavin synthase, alpha
GPY21_RS16700	COG0534	Mate efflux family protein
GPY21_RS16710	COG1793	dna ligase
GPY21_RS16745	COG2204	response regulator
GPY21_RS16755	COG0438	transferase activity, transferring glycosyl groups
GPY21_RS16790	COG0438	transferase activity, transferring glycosyl groups
GPY21_RS16795	COG1215	transferase activity, transferring glycosyl groups
GPY21_RS16800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY21_RS16810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY21_RS16825	COG1643	Atp-dependent helicase
GPY21_RS16830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY21_RS16845	COG3302	dmso reductase anchor subunit
GPY21_RS16850	COG0437	4 iron, 4 sulfur cluster binding
GPY21_RS16855	COG0243	molybdopterin cofactor binding
GPY21_RS16895	COG0443	Heat shock 70 kDa protein
GPY21_RS16900	COG0443	Heat shock 70 kDa protein
GPY21_RS16930	COG1132	(ABC) transporter
GPY21_RS16935	COG1132	(ABC) transporter
GPY21_RS16960	COG0814	amino acid
GPY21_RS16975	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY21_RS17045	COG1522	sequence-specific DNA binding
GPY21_RS17080	COG0515	serine threonine protein kinase
GPY21_RS17105	COG3501	Rhs element vgr protein
GPY21_RS17125	COG2885	chlorophyll binding
GPY21_RS17145	COG0739	heme binding
GPY21_RS17155	COG0861	Integral membrane protein TerC family
GPY21_RS17165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY21_RS17170	COG1328	CTP reductase activity
GPY21_RS17175	COG1280	lysine exporter protein (LysE YggA)
GPY21_RS17185	COG5001	Diguanylate cyclase
GPY21_RS17185	COG3300	MHYT domain
GPY21_RS17195	COG4191	Histidine kinase
GPY21_RS17195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY21_RS17200	COG0471	metal ion transport
GPY21_RS17235	COG0583	DNA-binding transcription factor activity
GPY21_RS17240	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY21_RS17470	COG1783	phage Terminase large subunit
GPY21_RS17515	COG0557	exoribonuclease II activity
GPY21_RS17520	COG1278	Cold shock
GPY21_RS17630	COG0625	glutathione transferase activity
GPY21_RS17640	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY21_RS17650	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY21_RS17660	COG0601	transmembrane transport
GPY21_RS17665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY21_RS17670	COG0444	Belongs to the ABC transporter superfamily
GPY21_RS17690	COG3291	Pkd domain containing protein
GPY21_RS17700	COG1177	transmembrane transport
GPY21_RS17705	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY21_RS17715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY21_RS17720	COG2423	ornithine cyclodeaminase activity
GPY21_RS17740	COG3938	Belongs to the proline racemase family
GPY21_RS17770	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY21_RS17775	COG1451	nucleotide metabolic process
GPY21_RS17780	COG3475	LICD family
GPY21_RS17785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY21_RS17790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY21_RS17810	COG0583	DNA-binding transcription factor activity
GPY21_RS17830	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY21_RS17835	COG4139	cobalamin transport
GPY21_RS17840	COG2988	succinylglutamate desuccinylase activity
GPY21_RS17865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY21_RS17870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY21_RS17875	COG0702	epimerase
GPY21_RS17885	COG2925	Exonuclease
GPY21_RS17890	COG1380	Effector of murein hydrolase LrgA
GPY21_RS17895	COG1346	cytolysis
GPY21_RS17900	COG0295	cytidine deaminase activity
GPY21_RS17905	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY21_RS17910	COG0500	methyltransferase
GPY21_RS17920	COG0776	regulation of translation
GPY21_RS17935	COG0072	phenylalanine-tRNA ligase activity
GPY21_RS17935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY21_RS17940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY21_RS17945	COG3706	GGDEF domain
GPY21_RS17975	COG0393	Putative heavy-metal-binding
GPY21_RS17985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY21_RS17995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY21_RS18010	COG2188	Transcriptional regulator
GPY21_RS18015	COG1228	amidohydrolase
GPY21_RS18020	COG0010	Belongs to the arginase family
GPY21_RS18025	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY21_RS18030	COG2986	histidine ammonia-lyase
GPY21_RS18045	COG0277	FAD linked oxidase domain protein
GPY21_RS18045	COG0247	lactate metabolic process
GPY21_RS18080	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY21_RS18095	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GPY21_RS18100	COG1643	Atp-dependent helicase
GPY21_RS18105	COG0281	malic enzyme
GPY21_RS18110	COG2949	membrane
GPY21_RS18115	COG0471	metal ion transport
GPY21_RS18120	COG0745	RESPONSE REGULATOR receiver
GPY21_RS18120	COG3706	GGDEF domain
GPY21_RS18140	COG0492	ferredoxin-NADP+ reductase activity
GPY21_RS18145	COG4988	ABC transporter
GPY21_RS18150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY21_RS18155	COG3048	D-serine ammonia-lyase activity
GPY21_RS18160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY21_RS18170	COG4191	Histidine kinase
GPY21_RS18170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY21_RS18185	COG3070	regulator of competence-specific genes
GPY21_RS18200	COG2431	L-lysine efflux transmembrane transporter activity
GPY21_RS18210	COG0076	glutamate decarboxylase activity
GPY21_RS18215	COG1737	Transcriptional regulator
GPY21_RS18230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY21_RS18235	COG2985	domain, Protein
GPY21_RS18235	COG3273	potassium ion transport
GPY21_RS18240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY21_RS18255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY21_RS18270	COG4181	ATPase activity
GPY21_RS18275	COG0534	Mate efflux family protein
GPY21_RS18285	COG3005	denitrification pathway
GPY21_RS18315	COG2814	Major facilitator Superfamily
GPY21_RS18320	COG1187	pseudouridine synthase activity
GPY21_RS18325	COG1061	Type III restriction enzyme res subunit
GPY21_RS18335	COG0745	RESPONSE REGULATOR receiver
GPY21_RS18340	COG2205	protein histidine kinase activity
GPY21_RS18345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY21_RS18375	COG3313	Fe-S protein
GPY21_RS18400	COG0493	'glutamate synthase
GPY21_RS18410	COG0398	Pfam SNARE associated Golgi protein
GPY21_RS18415	COG4134	Bacterial extracellular solute-binding protein
GPY21_RS18420	COG4135	transport system, permease component
GPY21_RS18425	COG4136	ATPase activity
GPY21_RS18430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY21_RS18445	COG3604	Transcriptional regulator
GPY21_RS18450	COG1151	hydroxylamine reductase activity
GPY21_RS18455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY21_RS18465	COG0564	pseudouridine synthase activity
GPY21_RS18475	COG0733	neurotransmitter:sodium symporter activity
GPY21_RS18485	COG0626	cystathionine gamma-synthase activity
GPY21_RS18490	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY21_RS18495	COG5380	lipid catabolic process
GPY21_RS18500	COG2818	Glycosylase
GPY21_RS18515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS18520	COG1983	PspC domain protein
GPY21_RS18530	COG1842	Phage shock protein A
GPY21_RS18535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY21_RS18545	COG4168	peptide transport system, permease
GPY21_RS18550	COG4171	peptide transport system, permease
GPY21_RS18560	COG4172	Belongs to the ABC transporter superfamily
GPY21_RS18570	COG1227	inorganic diphosphatase activity
GPY21_RS18585	COG0243	molybdopterin cofactor binding
GPY21_RS18590	COG3005	denitrification pathway
GPY21_RS18595	COG4459	periplasmic nitrate reductase
GPY21_RS18600	COG0390	transport system, permease component
GPY21_RS18610	COG2116	formate transmembrane transporter activity
GPY21_RS18635	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY21_RS18640	COG1435	thymidine kinase activity
GPY21_RS18645	COG0215	cysteine-tRNA ligase activity
GPY21_RS18650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY21_RS18655	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY21_RS18660	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY21_RS18670	COG3012	SEC-C Motif Domain Protein
GPY21_RS18675	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY21_RS18675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY21_RS18680	COG0107	imidazoleglycerol-phosphate synthase activity
GPY21_RS18685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY21_RS18690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY21_RS18695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY21_RS18695	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY21_RS18700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY21_RS18705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY21_RS18710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY21_RS18725	COG1757	Na H antiporter
GPY21_RS18735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY21_RS18745	COG0482	sulfurtransferase activity
GPY21_RS18750	COG2915	High frequency lysogenization protein hflD homolog
GPY21_RS18755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY21_RS18780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY21_RS18795	COG0300	oxidoreductase activity
GPY21_RS18805	COG0501	Belongs to the peptidase M48B family
GPY21_RS18815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY21_RS18825	COG0156	8-amino-7-oxononanoate synthase activity
GPY21_RS18830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY21_RS18835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY21_RS18840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY21_RS18850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY21_RS18855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY21_RS18860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY21_RS18865	COG1674	ftsk spoiiie
GPY21_RS18875	COG0686	Belongs to the AlaDH PNT family
GPY21_RS18885	COG0583	DNA-binding transcription factor activity
GPY21_RS18900	COG3568	Endonuclease Exonuclease Phosphatase
GPY21_RS18930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY21_RS18935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS18950	COG0840	transmembrane signaling receptor activity
GPY21_RS18965	COG0784	Response regulator, receiver
GPY21_RS18965	COG5002	protein histidine kinase activity
GPY21_RS18975	COG0754	glutathionylspermidine amidase activity
GPY21_RS18985	COG3766	membrane
GPY21_RS18995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY21_RS19000	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY21_RS19005	COG2885	chlorophyll binding
GPY21_RS19010	COG0823	Involved in the tonB-independent uptake of proteins
GPY21_RS19025	COG0811	peptide transport
GPY21_RS19030	COG0824	Thioesterase
GPY21_RS19040	COG4890	Cyd operon protein YbgT
GPY21_RS19045	COG1294	oxidase, subunit
GPY21_RS19050	COG1271	oxidase subunit
GPY21_RS19055	COG2255	four-way junction helicase activity
GPY21_RS19060	COG0632	four-way junction helicase activity
GPY21_RS19065	COG0840	transmembrane signaling receptor activity
GPY21_RS19070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY21_RS19075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY21_RS19080	COG1801	Protein of unknown function DUF72
GPY21_RS19085	COG4106	trans-aconitate 2-methyltransferase activity
GPY21_RS19090	COG0500	methyltransferase
GPY21_RS19100	COG0189	ligase activity
GPY21_RS19100	COG4067	protein conserved in archaea
GPY21_RS19120	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY21_RS19125	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY21_RS19130	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY21_RS19135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY21_RS19140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY21_RS19145	COG0745	RESPONSE REGULATOR receiver
GPY21_RS19150	COG3381	protein complex oligomerization
GPY21_RS19155	COG1609	Transcriptional regulator
GPY21_RS19160	COG3070	regulator of competence-specific genes
GPY21_RS19180	COG0297	glycogen (starch) synthase activity
GPY21_RS19185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY21_RS19190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY21_RS19200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY21_RS19210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY21_RS19215	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY21_RS19220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY21_RS19230	COG0542	response to heat
GPY21_RS19235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY21_RS19240	COG1278	Cold shock
GPY21_RS19250	COG1187	pseudouridine synthase activity
GPY21_RS19255	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY21_RS19265	COG1199	ATP-dependent helicase activity
GPY21_RS19270	COG0730	response to heat
GPY21_RS19275	COG3923	Primosomal replication protein n
GPY21_RS19285	COG0708	Exodeoxyribonuclease III
GPY21_RS19300	COG4215	(ABC) transporter
GPY21_RS19330	COG1882	Formate acetyltransferase
GPY21_RS19340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY21_RS19350	COG3013	Belongs to the UPF0304 family
GPY21_RS19360	COG2766	serine protein kinase
GPY21_RS19365	COG2718	Belongs to the UPF0229 family
GPY21_RS19370	COG2719	SpoVR family
GPY21_RS19375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY21_RS19385	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY21_RS19390	COG1132	(ABC) transporter
GPY21_RS19395	COG0658	competence protein
GPY21_RS19395	COG2333	competence protein COMEC
GPY21_RS19405	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY21_RS19410	COG1136	(ABC) transporter
GPY21_RS19415	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY21_RS19425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY21_RS19440	COG1252	NADH dehydrogenase
GPY21_RS19450	COG3150	esterase
GPY21_RS19475	COG0537	adenosine 5'-monophosphoramidase activity
GPY21_RS19505	COG0516	GMP reductase activity
GPY21_RS19505	COG0517	IMP dehydrogenase activity
GPY21_RS19515	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY21_RS19520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY21_RS19525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY21_RS19535	COG2199	diguanylate cyclase activity
GPY21_RS19550	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY21_RS19555	COG1946	Acyl-CoA thioesterase
GPY21_RS19565	COG1522	sequence-specific DNA binding
GPY21_RS19595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY21_RS19600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS19645	COG0477	Major facilitator Superfamily
GPY21_RS19650	COG2855	membrane
GPY21_RS19670	COG1441	menaquinone biosynthetic process
GPY21_RS19675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY21_RS19680	COG0596	Alpha beta hydrolase
GPY21_RS19685	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY21_RS19690	COG1169	isochorismate synthase
GPY21_RS19695	COG0436	Aminotransferase
GPY21_RS19700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY21_RS19705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY21_RS19720	COG1555	photosystem II stabilization
GPY21_RS19725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY21_RS19730	COG0776	regulation of translation
GPY21_RS19735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY21_RS19740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY21_RS19750	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY21_RS19760	COG2204	response regulator
GPY21_RS19770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY21_RS19775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY21_RS19780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY21_RS19785	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY21_RS19805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY21_RS19810	COG0569	domain protein
GPY21_RS19815	COG0513	Belongs to the DEAD box helicase family
GPY21_RS19820	COG1253	flavin adenine dinucleotide binding
GPY21_RS19850	COG0318	PFAM AMP-dependent synthetase and ligase
GPY21_RS19850	COG0204	Acyl-transferase
GPY21_RS19855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY21_RS19860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY21_RS19875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY21_RS19880	COG1216	Glycosyl transferase, family 2
GPY21_RS19885	COG2986	histidine ammonia-lyase
GPY21_RS19910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY21_RS19915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY21_RS19920	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS19925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY21_RS19940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY21_RS19945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY21_RS19950	COG0583	DNA-binding transcription factor activity
GPY21_RS19955	COG2951	lytic endotransglycosylase activity
GPY21_RS19960	COG3100	YcgL domain-containing protein
GPY21_RS19965	COG0850	regulation of cytokinetic process
GPY21_RS19970	COG2894	cell division
GPY21_RS19975	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY21_RS19980	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY21_RS19985	COG0318	PFAM AMP-dependent synthetase and ligase
GPY21_RS19990	COG2267	carboxylic ester hydrolase activity
GPY21_RS20005	COG1214	PFAM Peptidase M22, glycoprotease
GPY21_RS20010	COG1199	ATP-dependent helicase activity
GPY21_RS20015	COG0788	formyltetrahydrofolate deformylase activity
GPY21_RS20020	COG3102	Protein conserved in bacteria
GPY21_RS20030	COG0018	arginyl-trna synthetase
GPY21_RS20050	COG1918	ferrous iron import across plasma membrane
GPY21_RS20065	COG4977	sequence-specific DNA binding
GPY21_RS20070	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY21_RS20075	COG1121	(ABC) transporter
GPY21_RS20080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY21_RS20090	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY21_RS20095	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY21_RS20100	COG0567	Dehydrogenase, E1 component
GPY21_RS20105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY21_RS20110	COG1053	succinate dehydrogenase
GPY21_RS20115	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY21_RS20120	COG2009	succinate dehydrogenase
GPY21_RS20130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY21_RS20140	COG0033	Phosphoglucomutase
GPY21_RS20145	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY21_RS20150	COG0596	Alpha beta hydrolase
GPY21_RS20160	COG0716	FMN binding
GPY21_RS20170	COG0735	belongs to the Fur family
GPY21_RS20175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY21_RS20180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY21_RS20180	COG1263	PTS System
GPY21_RS20180	COG2190	(PTS) system
GPY21_RS20190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY21_RS20195	COG1846	Transcriptional regulator
GPY21_RS20195	COG1940	carbohydrate kinase activity
GPY21_RS20200	COG4651	solute:proton antiporter activity
GPY21_RS20200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY21_RS20205	COG0367	asparagine synthase
GPY21_RS20210	COG0250	Participates in transcription elongation, termination and antitermination
GPY21_RS20215	COG3104	oligopeptide transport
GPY21_RS20220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY21_RS20225	COG0563	adenylate kinase activity
GPY21_RS20230	COG0326	Molecular chaperone. Has ATPase activity
GPY21_RS20235	COG3710	Transcriptional regulator
GPY21_RS20255	COG0622	Phosphoesterase
GPY21_RS20285	COG1090	epimerase
GPY21_RS20290	COG0300	oxidoreductase activity
GPY21_RS20300	COG3118	belongs to the thioredoxin family
GPY21_RS20305	COG0330	HflC and HflK could
GPY21_RS20330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY21_RS20335	COG3115	cell septum assembly
GPY21_RS20340	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY21_RS20345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY21_RS20355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY21_RS20360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY21_RS20365	COG2190	(PTS) system
GPY21_RS20375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS20380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS20390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS20400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY21_RS20410	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY21_RS20410	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY21_RS20415	COG1706	bacterial-type flagellum-dependent cell motility
GPY21_RS20420	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY21_RS20425	COG4786	Flagellar basal body rod
GPY21_RS20430	COG4787	bacterial-type flagellum-dependent cell motility
GPY21_RS20440	COG1749	Flagellar hook protein flgE
GPY21_RS20445	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY21_RS20450	COG1558	bacterial-type flagellum-dependent cell motility
GPY21_RS20455	COG1815	bacterial-type flagellum-dependent cell motility
GPY21_RS20460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY21_RS20465	COG0835	chemotaxis
GPY21_RS20465	COG0784	Response regulator, receiver
GPY21_RS20525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY21_RS20530	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY21_RS20545	COG2217	Heavy metal translocating P-type atpase
GPY21_RS20545	COG2608	mercury ion transmembrane transporter activity
GPY21_RS20585	COG2840	Smr protein MutS2
GPY21_RS20590	COG1187	pseudouridine synthase activity
GPY21_RS20600	COG0737	Belongs to the 5'-nucleotidase family
GPY21_RS20605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY21_RS20610	COG2912	Transglutaminase-like superfamily
GPY21_RS20615	COG3094	Invasion gene expression up-regulator, SirB
GPY21_RS20620	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY21_RS20625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY21_RS20630	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY21_RS20645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY21_RS20650	COG0193	aminoacyl-tRNA hydrolase activity
GPY21_RS20655	COG0012	GTP binding
GPY21_RS20770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY21_RS20780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY21_RS20785	COG1702	phosphate starvation-inducible protein PhoH
GPY21_RS20790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY21_RS20795	COG4535	Mg2 and Co2 transporter CorC
GPY21_RS20800	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY21_RS20805	COG2888	peptidyl-tyrosine sulfation
GPY21_RS20810	COG0495	leucyl-tRNA aminoacylation
GPY21_RS20815	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY21_RS20820	COG1466	dna polymerase III delta subunit
GPY21_RS20825	COG0799	negative regulation of ribosome biogenesis
GPY21_RS20830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY21_RS20835	COG0768	penicillin binding
GPY21_RS20840	COG0772	Belongs to the SEDS family
GPY21_RS20845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY21_RS20850	COG1686	Belongs to the peptidase S11 family
GPY21_RS20855	COG2921	Belongs to the UPF0250 family
GPY21_RS20860	COG0321	lipoyl(octanoyl) transferase activity
GPY21_RS20865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY21_RS20870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY21_RS20875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY21_RS20890	COG0366	Alpha amylase catalytic
GPY21_RS20895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY21_RS20895	COG1263	PTS System
GPY21_RS20905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY21_RS20915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY21_RS20920	COG2011	ABC-type metal ion transport system permease component
GPY21_RS20925	COG1464	Belongs to the NlpA lipoprotein family
GPY21_RS20930	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY21_RS20940	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY21_RS20940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY21_RS20950	COG3706	GGDEF domain
GPY21_RS20950	COG0745	RESPONSE REGULATOR receiver
GPY21_RS20955	COG1611	Belongs to the LOG family
GPY21_RS20960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY21_RS20970	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GPY21_RS20975	COG2363	Small membrane protein
GPY21_RS20985	COG0583	DNA-binding transcription factor activity
GPY21_RS20990	COG0301	tRNA thio-modification
GPY21_RS20990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY21_RS20995	COG2885	chlorophyll binding
GPY21_RS21000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY21_RS21005	COG1722	exodeoxyribonuclease VII activity
GPY21_RS21010	COG0142	geranyltranstransferase activity
GPY21_RS21015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY21_RS21020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY21_RS21025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY21_RS21030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY21_RS21050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY21_RS21050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY21_RS21055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY21_RS21060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY21_RS21065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY21_RS21080	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY21_RS21085	COG2252	PERMEase
GPY21_RS21090	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY21_RS21115	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY21_RS21115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY21_RS21125	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY21_RS21135	COG0590	tRNA wobble adenosine to inosine editing
GPY21_RS21140	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY21_RS21165	COG4969	Belongs to the N-Me-Phe pilin family
GPY21_RS21180	COG0484	heat shock protein binding
GPY21_RS21185	COG0443	Heat shock 70 kDa protein
GPY21_RS21190	COG1301	dicarboxylic acid transport
GPY21_RS21195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY21_RS21200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY21_RS21210	COG0497	DNA recombination
GPY21_RS21215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY21_RS21220	COG2914	Belongs to the UPF0125 (RnfH) family
GPY21_RS21225	COG2867	negative regulation of translational initiation
GPY21_RS21230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY21_RS21250	COG0583	DNA-binding transcription factor activity
GPY21_RS21255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY21_RS21255	COG3153	acetyltransferase
GPY21_RS21275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY21_RS21280	COG2873	o-acetylhomoserine
GPY21_RS21315	COG1115	amino acid carrier protein
GPY21_RS21325	COG1584	GPR1 FUN34 yaaH family protein
GPY21_RS21335	COG1757	Na H antiporter
GPY21_RS21340	COG0519	Catalyzes the synthesis of GMP from XMP
GPY21_RS21340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY21_RS21345	COG0517	IMP dehydrogenase activity
GPY21_RS21345	COG0516	GMP reductase activity
GPY21_RS21350	COG1570	exodeoxyribonuclease VII activity
GPY21_RS21365	COG1160	GTP binding
GPY21_RS21370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY21_RS21375	COG2976	Protein conserved in bacteria
GPY21_RS21380	COG0124	histidyl-tRNA synthetase
GPY21_RS21385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY21_RS21400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY21_RS21405	COG0105	UTP biosynthetic process
GPY21_RS21410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY21_RS21415	COG2975	iron-sulfur cluster assembly
GPY21_RS21420	COG0633	Ferredoxin
GPY21_RS21425	COG0443	Heat shock 70 kDa protein
GPY21_RS21430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY21_RS21440	COG0822	iron-sulfur transferase activity
GPY21_RS21445	COG1104	cysteine desulfurase activity
GPY21_RS21450	COG1959	2 iron, 2 sulfur cluster binding
GPY21_RS21460	COG0483	inositol monophosphate 1-phosphatase activity
GPY21_RS21470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY21_RS21475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY21_RS21480	COG1862	Preprotein translocase
GPY21_RS21485	COG0343	queuine tRNA-ribosyltransferase activity
GPY21_RS21490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY21_RS21500	COG0517	IMP dehydrogenase activity
GPY21_RS21510	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY21_RS21520	COG0583	DNA-binding transcription factor activity
GPY21_RS21525	COG0450	alkyl hydroperoxide reductase
GPY21_RS21530	COG3142	Participates in the control of copper homeostasis
GPY21_RS21540	COG0704	Plays a role in the regulation of phosphate uptake
GPY21_RS21545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY21_RS21550	COG0581	inorganic phosphate transmembrane transporter activity
GPY21_RS21560	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY21_RS21565	COG0248	Ppx GppA phosphatase
GPY21_RS21575	COG5002	protein histidine kinase activity
GPY21_RS21580	COG0745	RESPONSE REGULATOR receiver
GPY21_RS21585	COG2974	May be involved in recombination
GPY21_RS21595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY21_RS21655	COG0542	response to heat
GPY21_RS21665	COG0564	pseudouridine synthase activity
GPY21_RS21670	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY21_RS21675	COG0741	lytic transglycosylase activity
GPY21_RS21680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY21_RS21685	COG0077	Prephenate dehydratase
GPY21_RS21685	COG1605	Chorismate mutase
GPY21_RS21690	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY21_RS21695	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY21_RS21705	COG0488	(ABC) transporter
GPY21_RS21720	COG0739	heme binding
GPY21_RS21725	COG1605	Chorismate mutase
GPY21_RS21725	COG0287	Prephenate dehydrogenase
GPY21_RS21730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY21_RS21735	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY21_RS21740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY21_RS21745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY21_RS21760	COG1966	Carbon starvation protein
GPY21_RS21765	COG3275	phosphorelay sensor kinase activity
GPY21_RS21770	COG3279	Response regulator of the LytR AlgR family
GPY21_RS21775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY21_RS21780	COG1047	Peptidyl-prolyl cis-trans
GPY21_RS21785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY21_RS21790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY21_RS21795	COG0196	riboflavin kinase activity
GPY21_RS21800	COG0728	peptidoglycan biosynthetic process
GPY21_RS21805	COG0268	Binds directly to 16S ribosomal RNA
GPY21_RS21815	COG0640	Transcriptional regulator
GPY21_RS21825	COG0583	DNA-binding transcription factor activity
GPY21_RS21830	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY21_RS21840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY21_RS21845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY21_RS21850	COG0730	response to heat
GPY21_RS21860	COG0494	nUDIX hydrolase
GPY21_RS21870	COG3066	DNA modification
GPY21_RS21880	COG0667	Aldo Keto reductase
GPY21_RS21895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY21_RS21905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY21_RS21910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY21_RS21920	COG0716	FMN binding
GPY21_RS21930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY21_RS21935	COG0513	Belongs to the DEAD box helicase family
GPY21_RS21940	COG3022	response to hydroperoxide
GPY21_RS21945	COG1115	amino acid carrier protein
GPY21_RS21960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY21_RS21970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY21_RS21975	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY21_RS21980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY21_RS21985	COG0083	homoserine kinase activity
GPY21_RS22000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY21_RS22015	COG0745	RESPONSE REGULATOR receiver
GPY21_RS22025	COG2198	Histidine kinase
GPY21_RS22025	COG0784	Response regulator, receiver
GPY21_RS22025	COG5002	protein histidine kinase activity
GPY21_RS22030	COG2203	Gaf domain
GPY21_RS22030	COG3706	GGDEF domain
GPY21_RS22030	COG5001	Diguanylate cyclase
GPY21_RS22030	COG4251	negative regulation of phosphorylation
GPY21_RS22035	COG1242	4 iron, 4 sulfur cluster binding
GPY21_RS22040	COG0069	glutamate synthase activity
GPY21_RS22040	COG0067	glutamate synthase
GPY21_RS22040	COG0070	glutamate synthase
GPY21_RS22050	COG0069	glutamate synthase activity
GPY21_RS22050	COG0067	glutamate synthase
GPY21_RS22050	COG0070	glutamate synthase
GPY21_RS22055	COG0493	'glutamate synthase
GPY21_RS22065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY21_RS22075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY21_RS22080	COG2860	membrane
GPY21_RS22085	COG0583	DNA-binding transcription factor activity
GPY21_RS22090	COG0730	response to heat
GPY21_RS22100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY21_RS22105	COG0505	Belongs to the CarA family
GPY21_RS22110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY21_RS22115	COG0494	nUDIX hydrolase
GPY21_RS22120	COG0653	protein targeting
GPY21_RS22130	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY21_RS22135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY21_RS22140	COG0849	cell division
GPY21_RS22145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY21_RS22150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY21_RS22155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY21_RS22160	COG0772	Belongs to the SEDS family
GPY21_RS22165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY21_RS22170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY21_RS22175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY21_RS22180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY21_RS22185	COG0768	penicillin binding
GPY21_RS22190	COG3116	cell division
GPY21_RS22195	COG0275	rRNA processing
GPY21_RS22210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY21_RS22220	COG0792	nuclease activity
GPY21_RS22225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY21_RS22230	COG2823	Periplasmic or secreted lipoprotein
GPY21_RS22235	COG2969	positive regulation of protein catabolic process
GPY21_RS22240	COG0625	glutathione transferase activity
GPY21_RS22245	COG2857	Cytochrome c1
GPY21_RS22250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY21_RS22255	COG0723	plastoquinol--plastocyanin reductase activity
GPY21_RS22260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY21_RS22265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY21_RS22275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY21_RS22285	COG3105	Protein conserved in bacteria
GPY21_RS22295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY21_RS22300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY21_RS22305	COG0187	DNA topoisomerase II activity
GPY21_RS22310	COG3150	esterase
GPY21_RS22320	COG3151	Protein conserved in bacteria
GPY21_RS22325	COG0494	nUDIX hydrolase
GPY21_RS22330	COG1538	Outer membrane efflux protein
GPY21_RS22335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY21_RS22335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY21_RS22340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY21_RS22355	COG3025	triphosphatase activity
GPY21_RS22360	COG1392	Phosphate transport regulator
GPY21_RS22365	COG0306	phosphate transporter
GPY21_RS22370	COG4991	sh3 domain protein
GPY21_RS22380	COG3409	Peptidoglycan-binding domain 1 protein
GPY21_RS22380	COG3267	Type II secretory pathway component ExeA
GPY21_RS22385	COG0617	tRNA 3'-terminal CCA addition
GPY21_RS22390	COG1968	undecaprenyl-diphosphatase activity
GPY21_RS22395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY21_RS22400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY21_RS22405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY21_RS22410	COG0596	Alpha beta hydrolase
GPY21_RS22415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY21_RS22420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY21_RS22425	COG1610	YqeY-like protein
GPY21_RS22430	COG0358	DNA primase activity
GPY21_RS22435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY21_RS22445	COG1464	Belongs to the NlpA lipoprotein family
GPY21_RS22455	COG2207	Transcriptional regulator
GPY21_RS22490	COG2213	PTS system mannitol-specific
GPY21_RS22490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY21_RS22495	COG0246	Mannitol dehydrogenase
GPY21_RS22500	COG3722	fumarate hydratase activity
GPY21_RS22515	COG1461	Dihydroxyacetone kinase
GPY21_RS22520	COG2376	Dihydroxyacetone kinase
GPY21_RS22530	COG5002	protein histidine kinase activity
GPY21_RS22545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY21_RS22550	COG1349	DNA-binding transcription factor activity
GPY21_RS22560	COG0469	pyruvate kinase activity
GPY21_RS22570	COG3706	GGDEF domain
GPY21_RS22575	COG0440	acetolactate synthase activity
GPY21_RS22580	COG0028	Belongs to the TPP enzyme family
GPY21_RS22585	COG1022	Amp-dependent synthetase and ligase
GPY21_RS22590	COG0583	DNA-binding transcription factor activity
GPY21_RS22610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY21_RS22615	COG0473	3-isopropylmalate dehydrogenase activity
GPY21_RS22620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY21_RS22625	COG0066	3-isopropylmalate dehydratase activity
GPY21_RS22635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY21_RS22640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY21_RS22645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY21_RS22650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY21_RS22655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY21_RS22660	COG2967	ApaG domain
GPY21_RS22665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY21_RS22680	COG2966	Psort location CytoplasmicMembrane, score
GPY21_RS22685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY21_RS22695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY21_RS22700	COG0142	geranyltranstransferase activity
GPY21_RS22710	COG0039	L-malate dehydrogenase activity
GPY21_RS22745	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY21_RS22750	COG1178	ABC-type Fe3 transport system permease component
GPY21_RS22755	COG4143	(ABC) transporter
GPY21_RS22760	COG0163	prenyltransferase activity
GPY21_RS22765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY21_RS22775	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY21_RS22780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY21_RS22790	COG2105	PFAM AIG2 family protein
GPY21_RS22795	COG2911	Protein conserved in bacteria
GPY21_RS22800	COG0729	surface antigen
GPY21_RS22805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY21_RS22815	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY21_RS22830	COG4181	ATPase activity
GPY21_RS22850	COG0529	Catalyzes the synthesis of activated sulfate
GPY21_RS22855	COG3273	potassium ion transport
GPY21_RS22855	COG0471	metal ion transport
GPY21_RS22865	COG2895	sulfate adenylyltransferase (ATP) activity
GPY21_RS22870	COG0175	sulfate reduction
GPY21_RS22875	COG1648	precorrin-2 dehydrogenase activity
GPY21_RS22875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY21_RS22880	COG0737	Belongs to the 5'-nucleotidase family
GPY21_RS22890	COG0513	Belongs to the DEAD box helicase family
GPY21_RS22895	COG2153	protein acetylation
GPY21_RS22905	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY21_RS22915	COG0203	ribosomal protein L17
GPY21_RS22920	COG0202	RNA polymerase activity
GPY21_RS22930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY21_RS22935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY21_RS22945	COG0201	protein transport
GPY21_RS22950	COG0200	Binds to the 23S rRNA
GPY21_RS22955	COG1841	ribosomal large subunit assembly
GPY21_RS22970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY21_RS22975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY21_RS22980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY21_RS22985	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY21_RS22990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY21_RS22995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY21_RS23000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY21_RS23005	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY21_RS23015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY21_RS23020	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY21_RS23025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY21_RS23030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY21_RS23040	COG0088	Forms part of the polypeptide exit tunnel
GPY21_RS23045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY21_RS23055	COG0254	rRNA binding
GPY21_RS23065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY21_RS23070	COG1609	Transcriptional regulator
GPY21_RS23080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY21_RS23085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY21_RS23090	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY21_RS23095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY21_RS23100	COG3074	FtsZ-dependent cytokinesis
GPY21_RS23110	COG1494	fructose-1,6-bisphosphatase
GPY21_RS23135	COG0149	triose-phosphate isomerase activity
GPY21_RS23140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY21_RS23160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY21_RS23175	COG1482	cell wall glycoprotein biosynthetic process
GPY21_RS23195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY21_RS23200	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPY21_RS23205	COG0438	transferase activity, transferring glycosyl groups
GPY21_RS23295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY21_RS23305	COG1560	Kdo2-lipid A biosynthetic process
GPY21_RS23315	COG0859	PFAM glycosyl transferase family 9
GPY21_RS23325	COG1519	Transferase
GPY21_RS23335	COG1028	Short-chain dehydrogenase reductase Sdr
GPY21_RS23385	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPY21_RS23395	COG3642	lipopolysaccharide core region biosynthetic process
GPY21_RS23400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY21_RS23405	COG0859	PFAM glycosyl transferase family 9
GPY21_RS23410	COG0463	Glycosyl transferase, family 2
GPY21_RS23425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY21_RS23430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY21_RS23440	COG2194	sulfuric ester hydrolase activity
GPY21_RS23450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY21_RS23455	COG2003	Belongs to the UPF0758 family
GPY21_RS23470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY21_RS23475	COG1309	transcriptional regulator
GPY21_RS23480	COG1560	Kdo2-lipid A biosynthetic process
GPY21_RS23485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY21_RS23490	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY21_RS23495	COG1561	YicC-like family, N-terminal region
GPY21_RS23515	COG2003	Belongs to the UPF0758 family
GPY21_RS23575	COG0328	RNA-DNA hybrid ribonuclease activity
GPY21_RS23620	COG4608	Belongs to the ABC transporter superfamily
GPY21_RS23625	COG0444	Belongs to the ABC transporter superfamily
GPY21_RS23630	COG0747	negative chemotaxis
GPY21_RS23635	COG4239	(ABC) transporter, permease
GPY21_RS23640	COG4174	ABC transporter (Permease)
GPY21_RS23665	COG0811	peptide transport
GPY21_RS23670	COG0848	biopolymer transport protein
GPY21_RS23685	COG0194	GDP metabolic process
GPY21_RS23690	COG1758	RNA polymerase activity
GPY21_RS23695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY21_RS23700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY21_RS23705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY21_RS23710	COG2233	PERMEase
GPY21_RS23715	COG2205	protein histidine kinase activity
GPY21_RS23720	COG0745	RESPONSE REGULATOR receiver
GPY21_RS23730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY21_RS23740	COG2183	response to ionizing radiation
GPY21_RS23750	COG0596	Alpha beta hydrolase
GPY21_RS23755	COG1040	competence protein
GPY21_RS23760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY21_RS23760	COG0316	Belongs to the HesB IscA family
GPY21_RS23765	COG0494	nUDIX hydrolase
GPY21_RS23770	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY21_RS23780	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY21_RS23785	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY21_RS23790	COG3156	type II secretion system protein K
GPY21_RS23795	COG4795	General secretion pathway protein
GPY21_RS23800	COG2165	general secretion pathway protein
GPY21_RS23805	COG2165	general secretion pathway protein
GPY21_RS23810	COG2165	general secretion pathway protein
GPY21_RS23815	COG1459	type II secretion system
GPY21_RS23820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY21_RS23830	COG3031	protein transport across the cell outer membrane
GPY21_RS23835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY21_RS23840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY21_RS23845	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY21_RS23855	COG0456	acetyltransferase
GPY21_RS23860	COG1490	D-aminoacyl-tRNA deacylase activity
GPY21_RS23865	COG1295	ribonuclease BN
GPY21_RS23885	COG0174	glutamine synthetase
GPY21_RS23895	COG3852	Histidine kinase
GPY21_RS23900	COG2204	response regulator
GPY21_RS23910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY21_RS23915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY21_RS23945	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY21_RS23955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY21_RS23955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY21_RS23980	COG0084	hydrolase, TatD family'
GPY21_RS23990	COG0805	protein transport
GPY21_RS24000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY21_RS24005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY21_RS24010	COG3165	ubiquinone biosynthetic process from chorismate
GPY21_RS24015	COG2226	methyltransferase
GPY21_RS24020	COG1322	Protein conserved in bacteria
GPY21_RS24035	COG0628	permease
GPY21_RS24085	COG2823	Periplasmic or secreted lipoprotein
GPY21_RS24095	COG2081	HI0933 family
GPY21_RS24105	COG1528	Iron-storage protein
GPY21_RS24110	COG0589	response to stress
GPY21_RS24115	COG0697	spore germination
GPY21_RS24125	COG0742	ribosomal rna small subunit methyltransferase
GPY21_RS24130	COG5002	protein histidine kinase activity
GPY21_RS24130	COG5001	Diguanylate cyclase
GPY21_RS24135	COG1522	sequence-specific DNA binding
GPY21_RS24140	COG0339	signal peptide processing
GPY21_RS24145	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY21_RS24150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY21_RS24155	COG0583	DNA-binding transcription factor activity
GPY21_RS24160	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY21_RS24165	COG0800	Aldolase
GPY21_RS24170	COG2610	gluconate transmembrane transporter activity
GPY21_RS24175	COG3265	gluconokinase activity
GPY21_RS24180	COG0129	dihydroxy-acid dehydratase activity
GPY21_RS24185	COG2076	Multidrug Resistance protein
GPY21_RS24195	COG0583	DNA-binding transcription factor activity
GPY21_RS24200	COG1609	Transcriptional regulator
GPY21_RS24240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY21_RS24250	COG0747	negative chemotaxis
GPY21_RS24255	COG4172	Belongs to the ABC transporter superfamily
GPY21_RS24320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY21_RS24325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY21_RS24335	COG2960	long-chain fatty acid transporting porin activity
GPY21_RS24340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY21_RS24345	COG0583	DNA-binding transcription factor activity
GPY21_RS24380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY21_RS24390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY21_RS24395	COG0408	coproporphyrinogen oxidase activity
GPY21_RS24400	COG0009	L-threonylcarbamoyladenylate synthase
GPY21_RS24405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY21_RS24410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY21_RS24415	COG0551	DNA topoisomerase type I activity
GPY21_RS24420	COG2922	Belongs to the Smg family
GPY21_RS24425	COG0758	DNA mediated transformation
GPY21_RS24435	COG0242	peptide deformylase activity
GPY21_RS24440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY21_RS24445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY21_RS24445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY21_RS24450	COG0569	domain protein
GPY21_RS24455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY21_RS24465	COG1272	protein, Hemolysin III
GPY21_RS24470	COG4326	sporulation control protein
GPY21_RS24480	COG3084	Protein conserved in bacteria
GPY21_RS24490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY21_RS24495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY21_RS24500	COG0204	Acyl-transferase
GPY21_RS24510	COG0606	chelatase, subunit chli
GPY21_RS24520	COG3978	acetolactate synthase activity
GPY21_RS24525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY21_RS24530	COG0129	dihydroxy-acid dehydratase activity
GPY21_RS24540	COG0583	DNA-binding transcription factor activity
GPY21_RS24545	COG2814	Major facilitator Superfamily
GPY21_RS24550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY21_RS24555	COG0765	amino acid transport
GPY21_RS24560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY21_RS24565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY21_RS24570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY21_RS24575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY21_RS24580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY21_RS24585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY21_RS24600	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY21_RS24605	COG3312	ion transport
GPY21_RS24610	COG1475	DNA binding
GPY21_RS24615	COG1192	Involved in chromosome partitioning
GPY21_RS24620	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY21_RS24625	COG0445	tRNA wobble uridine modification
GPY21_RS24630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY21_RS24680	COG3645	SOS response
GPY21_RS24685	COG3645	SOS response
GPY21_RS24695	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY21_RS24735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY21_RS24740	COG0706	membrane insertase activity
GPY21_RS24745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY21_RS24750	COG0594	ribonuclease P activity
GPY21_RS24760	COG1126	abc transporter atp-binding protein
GPY21_RS24785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY21_RS24790	COG0592	DNA-directed DNA polymerase activity
GPY21_RS24795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY21_RS24800	COG0187	DNA topoisomerase II activity
GPY21_RS24820	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY21_RS24825	COG3977	Valine--pyruvate aminotransferase
GPY21_RS24830	COG0366	Alpha amylase catalytic
GPY21_RS24835	COG0751	glycine-tRNA ligase activity
GPY21_RS24840	COG0752	glycyl-tRNA synthetase alpha subunit
GPY21_RS24845	COG2119	membrane
GPY21_RS24855	COG0425	Belongs to the sulfur carrier protein TusA family
GPY21_RS24870	COG0604	alcohol dehydrogenase
GPY21_RS24875	COG0183	Belongs to the thiolase family
GPY21_RS24880	COG1024	Enoyl-CoA hydratase
GPY21_RS24880	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY21_RS24885	COG1739	Uncharacterized protein family UPF0029
GPY21_RS24890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY21_RS24970	COG3335	DDE superfamily endonuclease
GPY21_RS24975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY21_RS24980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY21_RS24985	COG0352	thiamine-phosphate diphosphorylase activity
GPY21_RS24990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY21_RS24995	COG2104	thiamine diphosphate biosynthetic process
GPY21_RS25000	COG2022	thiamine diphosphate biosynthetic process
GPY21_RS25010	COG0006	proline dipeptidase activity
GPY21_RS25010	COG0006	proline dipeptidase activity
GPY21_RS25040	COG3220	belongs to the UPF0276 family
GPY21_RS25050	COG0210	DNA helicase
GPY21_RS25060	COG0405	Gamma-glutamyltransferase
GPY21_RS25065	COG1280	lysine exporter protein (LysE YggA)
GPY21_RS25075	COG2962	Rard protein
GPY21_RS25080	COG0514	ATP-dependent DNA helicase (RecQ)
GPY21_RS25095	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY21_RS25100	COG0248	Ppx GppA phosphatase
GPY21_RS25105	COG0513	Belongs to the DEAD box helicase family
GPY21_RS25110	COG3118	belongs to the thioredoxin family
GPY21_RS25115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY21_RS25130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY21_RS25135	COG0633	Ferredoxin
GPY21_RS25185	COG3071	HemY protein
GPY21_RS25190	COG2959	enzyme of heme biosynthesis
GPY21_RS25195	COG1587	Uroporphyrinogen-III synthase
GPY21_RS25200	COG0181	hydroxymethylbilane synthase activity
GPY21_RS25205	COG3072	Adenylate cyclase
GPY21_RS25210	COG1965	Belongs to the frataxin family
GPY21_RS25220	COG0019	diaminopimelate decarboxylase activity
GPY21_RS25225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY21_RS25235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY21_RS25240	COG1011	Hydrolase
GPY21_RS25245	COG3287	FIST C domain
GPY21_RS25245	COG2200	EAL domain
GPY21_RS25245	COG2199	diguanylate cyclase activity
GPY21_RS25265	COG0561	phosphatase activity
GPY21_RS25270	COG2267	carboxylic ester hydrolase activity
GPY21_RS25275	COG1280	lysine exporter protein (LysE YggA)
GPY21_RS25280	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY21_RS25285	COG0640	Transcriptional regulator
GPY21_RS25290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity